TY - JOUR T1 - Prostate brachytherapy under local anesthesia; lessons from the first 600 patients. AN - 72914679; 15090277 AB - Local anesthesia for prostate brachytherapy was instituted at the Puget Sound Veterans Hospital in 1999, peforming the procedure in our own department without anesthesia personnel in attendance. The patient is brought into the simulator suite in the radiation oncology department, an i.v. line is started, a cardiac monitor attached, and a urinary catheter is inserted. He is then placed in the lithotomy position, using stirrups attached to the simulator table. A 6-8 cm patch of perineal skin and subcutaneous tissue is anesthetized by local infiltration of 1% lidocaine. The transrectal ultrasound (TRUS) probe is then inserted and positioned to reproduce the planning images. A 3.0 inch 22-gauge spinal needle is used to inject lidocaine up to the prostatic apex, in a pattern around the periphery of the prostate. Once the pelvic floor and prostatic apex are anesthetized, a 7.0-inch, 22-gauge spinal needle is inserted through an 18-gauge 3 inch spinal needle into the peripheral planned needle tracks, monitored by TRUS. As the needles are advanced to the prostatic base, about 1.0 cc of lidocaine solution is injected in the intraprostatic track. A total of 200 to 500 mg of lidocaine is used. As of December 2000, more than 600 patients have received implants under local anesthesia at Seattle, WA. Patients tolerate brachytherapy under local anesthesia surprisingly well. Post-implant CT-defined target coverage has ranged from 80% to 95%, well within published criteria for technical adequacy. Patients' typical implant pain score is 3, on a scale of 0-10. After a series of patient acceptance quality studies, we have abandoned the routine use of sedation, and relied instead on local lidocaine infiltration alone. In addition to a high degree of patient satisfaction, performing implants under local anesthesia allows for phenomenal logistical efficiencies and cost advantages. JF - Brachytherapy AU - Wallner, Kent AD - Radiation Oncology, Puget Sound Health Care System, Department of Veterans Affairs, Seattle, WA, USA. kent.wallner@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 145 EP - 148 VL - 1 IS - 3 SN - 1538-4721, 1538-4721 KW - Anesthetics, Local KW - 0 KW - Lidocaine KW - 98PI200987 KW - Index Medicus KW - Lidocaine -- administration & dosage KW - Anesthetics, Local -- administration & dosage KW - Patient Satisfaction KW - Prostate -- diagnostic imaging KW - Humans KW - Prostate -- pathology KW - Pain KW - Ultrasonography KW - Male KW - Brachytherapy -- adverse effects KW - Brachytherapy -- methods KW - Anesthesia, Local -- methods KW - Prostatic Neoplasms -- radiotherapy KW - Prostatic Neoplasms -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72914679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brachytherapy&rft.atitle=Prostate+brachytherapy+under+local+anesthesia%3B+lessons+from+the+first+600+patients.&rft.au=Wallner%2C+Kent&rft.aulast=Wallner&rft.aufirst=Kent&rft.date=2002-01-01&rft.volume=1&rft.issue=3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Brachytherapy&rft.issn=15384721&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-05 N1 - Date created - 2004-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Alcohol Use Disorders Identification Test (AUDIT) predicts alcohol withdrawal symptoms during inpatient detoxification. AN - 72123861; 12296504 AB - We evaluated whether the Alcohol Use Disorders Identification Test (AUDIT) predicted clinically meaningful alcohol withdrawal syndrome (AWS) in 118 alcohol dependent patients without a history of seizures. Patients were monitored by serial administration of the revised Clinical Institute Withdrawal Assessment Scale for Alcohol (CIWA-Ar) during inpatient detoxification. Patients (N = 55) who reached threshold level of AWS for receiving medication (CIWA-Ar > 9) scored significantly higher (p <.001) on the AUDIT total score, the dependence sub-scale, and the single item on morning drinking. Sensitivity, specificity, positive and negative predictive power, and screening efficiency showed the value of the AUDIT for identifying patients who developed AWS. The AUDIT should be explored alone and in combination with other parameters to improve screening for clinically meaningful AWS in other settings. JF - Journal of addictive diseases AU - Reoux, Joseph P AU - Malte, Carol A AU - Kivlahan, Daniel R AU - Saxon, Andrew J AD - Veterans Affairs Puget Sound Health Care System, Addictions Treatment Center, Seattle, WA 98108, USA. joe.reoux@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 81 EP - 91 VL - 21 IS - 4 SN - 1055-0887, 1055-0887 KW - Anti-Anxiety Agents KW - 0 KW - Benzodiazepines KW - 12794-10-4 KW - Index Medicus KW - Sensitivity and Specificity KW - Psychiatric Status Rating Scales KW - Hospitalization KW - Humans KW - Surveys and Questionnaires KW - Anti-Anxiety Agents -- therapeutic use KW - Predictive Value of Tests KW - Middle Aged KW - Male KW - Female KW - Alcoholism -- diagnosis KW - Alcohol Withdrawal Seizures -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72123861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+addictive+diseases&rft.atitle=The+Alcohol+Use+Disorders+Identification+Test+%28AUDIT%29+predicts+alcohol+withdrawal+symptoms+during+inpatient+detoxification.&rft.au=Reoux%2C+Joseph+P%3BMalte%2C+Carol+A%3BKivlahan%2C+Daniel+R%3BSaxon%2C+Andrew+J&rft.aulast=Reoux&rft.aufirst=Joseph&rft.date=2002-01-01&rft.volume=21&rft.issue=4&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Journal+of+addictive+diseases&rft.issn=10550887&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-02-26 N1 - Date created - 2002-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of aging on cardiac contractility in a rat model of chronic daunorubicin cardiotoxicity. AN - 72118830; 12271153 AB - Because the risk of chronic anthracycline cardiotoxicity increases with age, the effect of chronic daunorubicin was compared in young (6-9 mo) and senescent (24-26 mo) Fischer 344 rats in cumulative doses of 12 or 18 mg/kg. Senescent rats treated using 18 mg/kg of daunorubicin did not survive because of daunorubicin toxicity. Rats were euthanized 1 wk after the last dose of daunorubicin and ex vivo studies of isometric cardiac contractile function were done in left ventricular trabeculae carneae. In senescent rats given 12 mg/kg of daunorubicin, it caused significant impairment of contractility (dS/dt at 15 cpm; p = 0.001) that was not observed in either young adult group. In addition, the effect of 12 mg/kg of daunorubicin on contractility in senescent rats was significantly reduced compared to that in young rats administered 12 mg/kg of daunorubicin (p < 0.001), although the effect was similar to that in young rats given 18 mg/kg of daunorubicin. In rats receiving 12 mg/kg of daunorubicin, there was an age-dependent effect of daunorubicin on rate-related contractility and on Ca2+-induced contractility. Daunorubicinol, but not daunorubicin, concentrations were increased in the senescent rat heart tissue. This suggests that chronic daunorubicin cardiotoxicity increases with age, at least partly resulting from sarcoplasmic reticulum dysfunction caused by increased anthracycline exposure. JF - Cardiovascular toxicology AU - Cusack, Barry J AU - Young, Stephen P AU - Gabliel, Hervé AU - Olson, Richard D AD - Clinical Pharmacology and Gerontology Research Unit, Veterans Affairs Medical Center, Boise, ID 83702, USA. barry.cusack@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 99 EP - 109 VL - 2 IS - 2 SN - 1530-7905, 1530-7905 KW - Antibiotics, Antineoplastic KW - 0 KW - Calcium Channels KW - Triglycerides KW - Cholesterol KW - 97C5T2UQ7J KW - Creatinine KW - AYI8EX34EU KW - Daunorubicin KW - ZS7284E0ZP KW - Index Medicus KW - Ventricular Function, Left -- drug effects KW - Triglycerides -- blood KW - Animals KW - Dose-Response Relationship, Drug KW - Heart Diseases -- chemically induced KW - Heart Ventricles -- metabolism KW - Disease Models, Animal KW - Creatinine -- blood KW - Myocardium -- metabolism KW - Depression, Chemical KW - Rats KW - Models, Cardiovascular KW - Cholesterol -- blood KW - Rats, Inbred F344 KW - Sarcoplasmic Reticulum -- metabolism KW - Sarcoplasmic Reticulum -- drug effects KW - Calcium Channels -- drug effects KW - Heart Ventricles -- drug effects KW - Chronic Disease KW - Time Factors KW - Male KW - Daunorubicin -- pharmacology KW - Aging -- physiology KW - Antibiotics, Antineoplastic -- pharmacology KW - Daunorubicin -- adverse effects KW - Myocardial Contraction -- drug effects KW - Aging -- blood KW - Antibiotics, Antineoplastic -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72118830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cardiovascular+toxicology&rft.atitle=Effect+of+aging+on+cardiac+contractility+in+a+rat+model+of+chronic+daunorubicin+cardiotoxicity.&rft.au=Cusack%2C+Barry+J%3BYoung%2C+Stephen+P%3BGabliel%2C+Herv%C3%A9%3BOlson%2C+Richard+D&rft.aulast=Cusack&rft.aufirst=Barry&rft.date=2002-01-01&rft.volume=2&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Cardiovascular+toxicology&rft.issn=15307905&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-05 N1 - Date created - 2002-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - pH-dependent oxidant production following inhibition of the mitochondrial electron transport chain in pulmonary endothelial cells. AN - 72041098; 12200958 AB - We investigated the effect of changes in intracellular pH (pHi) and Na/H antiport activity on intracellular oxidant production in human pulmonary artery endothelial cells (HPAEC) following disruption of cellular metabolism. Oxidant production was measured with oxidant-sensitive probes (2',7'-dichlorofluorescein diacetate [H2DCF], dihydroethidium [DHE]) following treatment with inhibitors of mitochondrial electron transport and glycolysis (antimycin/2-deoxyglucose, A/D). A/D treatment increased oxidant production in a dose-dependent fashion over 2 hours. Omission of 2-deoxyglucose did not alter the magnitude of oxidant production. Inhibition at more proximal sites in the mitochondrial electron transport chain inhibited oxidant production. These data suggested that the mitochondrial electron transport chain was the source of oxidant production. Fluorescent imaging experiments confirmed the mitochondrial origin of the increased oxidant production under these conditions. Maneuvers that reduced pHi and inhibited Na/H exchange (acidosis, specific Na/H exchange inhibitors) attenuated oxidant production, whereas maneuvers that raised pHi (monensin) potentiated oxidant production. The results with the pH-insensitive probe (DHE) confirmed that oxidant production was pH-dependent. Oxidant production preceded significant loss of cell viability at 6 h following A/D treatment. These results demonstrate that oxidant production following inhibition of mitochondrial electron transport in HPAEC is pH-dependent and may contribute to endothelial cell injury by increasing endogenous oxidative stress. JF - Endothelium : journal of endothelial cell research AU - Cutaia, M AU - Kroczynski, J AU - Tollefson, K AD - Pulmonary Disease Division, University of Pennsylvania School of Medicine, VA Medical Center, Philadelphia, Pennsylvania, USA. michael.cutaia@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 109 EP - 121 VL - 9 IS - 2 SN - 1062-3329, 1062-3329 KW - Fluorescent Dyes KW - 0 KW - Oxidants KW - Sodium-Hydrogen Antiporter KW - antimycin KW - 11118-72-2 KW - Antimycin A KW - 642-15-9 KW - Deoxyglucose KW - 9G2MP84A8W KW - Index Medicus KW - Glycolysis -- drug effects KW - Cell Survival -- drug effects KW - Sodium-Hydrogen Antiporter -- metabolism KW - Cells, Cultured KW - Hydrogen-Ion Concentration KW - Humans KW - Mitochondria -- drug effects KW - Mitochondria -- metabolism KW - Sodium-Hydrogen Antiporter -- antagonists & inhibitors KW - Deoxyglucose -- pharmacology KW - Antimycin A -- pharmacology KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Endothelium, Vascular -- cytology KW - Antimycin A -- analogs & derivatives KW - Oxidants -- metabolism KW - Electron Transport -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72041098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endothelium+%3A+journal+of+endothelial+cell+research&rft.atitle=pH-dependent+oxidant+production+following+inhibition+of+the+mitochondrial+electron+transport+chain+in+pulmonary+endothelial+cells.&rft.au=Cutaia%2C+M%3BKroczynski%2C+J%3BTollefson%2C+K&rft.aulast=Cutaia&rft.aufirst=M&rft.date=2002-01-01&rft.volume=9&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Endothelium+%3A+journal+of+endothelial+cell+research&rft.issn=10623329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-24 N1 - Date created - 2002-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Management of systemic candidal infections in the intensive care unit. AN - 71415340; 11813465 AB - Risk factors and treatment strategies for systemic candidal infections in the intensive care unit (ICU) are discussed. The past two decades have seen a dramatic increase in the frequency of infections caused by Candida species. Risk factors associated with candidemia include treatment with multiple antimicrobials for extended periods, presence of central venous catheters, total parenteral nutrition, colonization by Candida species, abdominal surgery, prolonged stay in the ICU, and compromised immune status. Since the 1960s, conventional amphotericin B has been the primary treatment option for fungal infections. Although effective, amphotericin B has extensive toxicity. Three lipid-based formulations of amphotericin B have been developed in an attempt to decrease nephrotoxicity and improve drug delivery. Practitioners have also been offered alternatives by the introduction of less toxic azole antifungals, such as ketoconazole, fluconazole, and itraconazole; however, their widespread use has resulted in other problems, such as the selection of resistant isolates. There is controversy concerning fluconazole's effectiveness. In the treatment of systemic candidal infections, especially in critically ill patients. Clinical trials do not support the prophylactic or empirical use of fluconazole in the ICU. Treating patients who have no microbiological evidence of infection provides no therapeutic benefit and shifts the fungal flora to noncandidal strains that are more resistant to fluconazole. Patients in ICUs are often susceptible to systemic candidal infection. Preemptive therapy with fluconazole may reduce mortality in high-risk patients. Fluconazole and amphotericin B appear equally effective in treating established systemic candidal infections. JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Kam, Linda W AU - Lin, Jason D AD - James A. Haley Veterans Affairs Medical Center, Pharmacy Department (119), 13000 Bruce B. Downs Boulevard, Tampa, FL 33612, USA. linda.kam@med.va.gov Y1 - 2002/01/01/ PY - 2002 DA - 2002 Jan 01 SP - 33 EP - 41 VL - 59 IS - 1 SN - 1079-2082, 1079-2082 KW - Antifungal Agents KW - 0 KW - Amphotericin B KW - 7XU7A7DROE KW - Fluconazole KW - 8VZV102JFY KW - Index Medicus KW - Risk Factors KW - Humans KW - Cross Infection -- etiology KW - Drug Resistance, Microbial KW - Cross Infection -- epidemiology KW - Cross Infection -- drug therapy KW - Antibiotic Prophylaxis KW - Candidiasis -- drug therapy KW - Candidiasis -- epidemiology KW - Fluconazole -- therapeutic use KW - Intensive Care Units KW - Candidiasis -- etiology KW - Amphotericin B -- therapeutic use KW - Antifungal Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71415340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Management+of+systemic+candidal+infections+in+the+intensive+care+unit.&rft.au=Kam%2C+Linda+W%3BLin%2C+Jason+D&rft.aulast=Kam&rft.aufirst=Linda&rft.date=2002-01-01&rft.volume=59&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-24 N1 - Date created - 2002-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ang II accumulation in rat renal endosomes during Ang II-induced hypertension: role of AT(1) receptor. AN - 71400065; 11799089 AB - Hypertension induced by long-term infusion of angiotensin II (Ang II) is associated with augmented intrarenal Ang II levels to a greater extent than can be explained on the basis of the circulating Ang II levels. Although part of this augmentation is due to AT(1) receptor-dependent internalization, the intracellular compartments involved in this Ang II accumulation remain unknown. In the present study, we sought to determine whether Ang II trafficking into renal cortical endosomes is increased during Ang II hypertension, and if so, whether the AT(1) receptor antagonist, candesartan, prevents this accumulation. Compared with controls (n=12; 114+/-2 mm Hg), Ang II-infused rats (n=12; 80 ng/kg/min, SC, for 13 days) developed hypertension with systolic blood pressure rising to 185+/-4 mm Hg by Day 12. In Ang II hypertensive rats, plasma renin activity was suppressed, whereas plasma and kidney Ang II levels were increased by 3-fold (348+/-58 versus 119+/-16 fmol/mL) and 2-fold (399+/-39 versus 186+/-26 fmol/g). Intracellular endosomal Ang II levels were increased by more than 10-fold (1100+/-283 versus 71+/-12 fmol/mg protein), whereas intermicrovillar cleft Ang II levels were increased by more than 2-fold (88+/-22 versus 37+/-7 fmol/mg protein). Flow cytometric analysis detected significant increases in AT(1A) receptor antibody binding in endosomal and intermicrovillar clefts of Ang II-infused rats. The hypertension induced by Ang II was prevented in rats treated concurrently with candesartan (2 mg/kg/d, 119+/-3 mm Hg). Candesartan treatment (n=8) also prevented increases in kidney (215+/-19 fmol/g), endosomal (96+/-29 fmol/mg protein), and intermicrovillar cleft Ang II levels (11+/-2 fmol/mg protein). These results indicate that there is substantial intracellular accumulation of angiotensin peptides in renal cortical endosomes during Ang II-dependent hypertension via an AT(1) receptor-mediated process. JF - Hypertension (Dallas, Tex. : 1979) AU - Zhuo, Jia L AU - Imig, John D AU - Hammond, Timothy G AU - Orengo, Sheyla AU - Benes, Edmund AU - Navar, L Gabriel AD - Department of Physiology, Tulane University School of Medicine, Veterans Administration Medical Center , New Orleans, Louisiana 70112, USA. Y1 - 2002/01// PY - 2002 DA - January 2002 SP - 116 EP - 121 VL - 39 IS - 1 KW - Angiotensin Receptor Antagonists KW - 0 KW - Antibodies KW - Antihypertensive Agents KW - Benzimidazoles KW - Dextrans KW - Fluoresceins KW - Receptor, Angiotensin, Type 1 KW - Receptors, Angiotensin KW - Tetrazoles KW - fluorescein-dextran KW - Angiotensin II KW - 11128-99-7 KW - Angiotensin I KW - 9041-90-1 KW - Renin KW - EC 3.4.23.15 KW - candesartan KW - S8Q36MD2XX KW - Index Medicus KW - Animals KW - Angiotensin I -- blood KW - Benzimidazoles -- pharmacology KW - Microvilli -- metabolism KW - Fluoresceins -- pharmacokinetics KW - Antihypertensive Agents -- pharmacology KW - Renin -- blood KW - Rats KW - Tetrazoles -- pharmacology KW - Rats, Sprague-Dawley KW - Antibodies -- metabolism KW - Dextrans -- pharmacokinetics KW - Systole -- drug effects KW - Flow Cytometry KW - Blood Pressure -- drug effects KW - Male KW - Receptors, Angiotensin -- immunology KW - Angiotensin II -- blood KW - Kidney -- metabolism KW - Hypertension -- chemically induced KW - Receptors, Angiotensin -- metabolism KW - Kidney -- drug effects KW - Kidney -- ultrastructure KW - Endosomes -- metabolism KW - Angiotensin II -- pharmacokinetics KW - Hypertension -- metabolism KW - Angiotensin II -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71400065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Ang+II+accumulation+in+rat+renal+endosomes+during+Ang+II-induced+hypertension%3A+role+of+AT%281%29+receptor.&rft.au=Zhuo%2C+Jia+L%3BImig%2C+John+D%3BHammond%2C+Timothy+G%3BOrengo%2C+Sheyla%3BBenes%2C+Edmund%3BNavar%2C+L+Gabriel&rft.aulast=Zhuo&rft.aufirst=Jia&rft.date=2002-01-01&rft.volume=39&rft.issue=1&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=1524-4563&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-20 N1 - Date created - 2002-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transient neurological symptoms after subarachnoid meperidine. AN - 71386594; 11772831 AB - The syndrome of transient neurological symptoms (TNS) after subarachnoid use of local anesthetics, particularly lidocaine, has been well described. This syndrome has not been reported with the subarachnoid use of opioids. This case report describes TNS that occurred after administration of subarachnoid meperidine, an opioid with local anesthetic properties. JF - Anesthesia and analgesia AU - Lewis, Wilfred R AU - Perrino, Albert C AD - Department of Anesthesiology, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA. Wilfred.Lewis@med.va.gov Y1 - 2002/01// PY - 2002 DA - January 2002 SP - 213 EP - 4, table of contents VL - 94 IS - 1 SN - 0003-2999, 0003-2999 KW - Analgesics, Opioid KW - 0 KW - Meperidine KW - 9E338QE28F KW - Abridged Index Medicus KW - Index Medicus KW - Subarachnoid Space KW - Humans KW - Aged KW - Male KW - Pain -- etiology KW - Meperidine -- adverse effects KW - Anesthesia, Spinal -- adverse effects KW - Meperidine -- administration & dosage KW - Analgesics, Opioid -- adverse effects KW - Analgesics, Opioid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71386594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Transient+neurological+symptoms+after+subarachnoid+meperidine.&rft.au=Lewis%2C+Wilfred+R%3BPerrino%2C+Albert+C&rft.aulast=Lewis&rft.aufirst=Wilfred&rft.date=2002-01-01&rft.volume=94&rft.issue=1&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=00032999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-25 N1 - Date created - 2002-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Technical Skill and the Therapeutic Relationship: A Fundamental Dilemma in Cognitive-Behavioral and Insight-Oriented Therapy AN - 61493941; 200300313 AB - Perceived role conflicts that cognitive-behavioral therapists share with insight-oriented therapists in balancing the use of clinical techniques & attention to the therapeutic relationship are discussed. Clinical dilemmas that have arisen in traditional forms of insight-oriented treatment are examined in light of cognitive-behavior therapy. These dilemmas include (1) the necessary balance between technical interventions & maintenance of the therapeutic relationship, (2) the spontaneous, moment-to-moment patient-therapist interactions which constitute clinical judgment, (3) the notion of countertransference in the practice of cognitive-behavior therapy, (4) the treatment of historical/developmental influences upon behavior vs more contemporaneous influences, & (5) the manner in which cognitive-behavioral & the directive aspects of therapy borrow from the nurturant function of the psychotherapist. The multidimensional factors of clinical training that constitute the protracted role functions for the cognitive-behavior therapist are outlined. 101 References. Adapted from the source document. JF - Family Therapy AU - Scaturo, Douglas J AD - Behavioral Health Outpatient Clinic, Dept Veterans Affairs, Syracuse VA Medical Center, NY douglas.scaturo@med.va.gov Y1 - 2002///0, PY - 2002 DA - 0, 2002 SP - 1 EP - 21 VL - 29 IS - 1 SN - 0091-6544, 0091-6544 KW - Therapists KW - Transference (Psychology) KW - Client Relations KW - Psychotherapy KW - Role Conflict KW - Treatment Methods KW - article KW - 6121: therapeutic interventions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61493941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Family+Therapy&rft.atitle=Technical+Skill+and+the+Therapeutic+Relationship%3A+A+Fundamental+Dilemma+in+Cognitive-Behavioral+and+Insight-Oriented+Therapy&rft.au=Scaturo%2C+Douglas+J&rft.aulast=Scaturo&rft.aufirst=Douglas&rft.date=2002-01-01&rft.volume=29&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Family+Therapy&rft.issn=00916544&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Treatment Methods; Client Relations; Transference (Psychology); Psychotherapy; Therapists; Role Conflict ER - TY - JOUR T1 - Epidemiological and Clinical Aspects of Nonsteroidal Anti-inflammatory Drugs and Cancer Risks AN - 18431518; 5412234 AB - It is well known that about 70% of cancer cases are due to environmental, dietary, or lifestyle factors. Accordingly, these cases may be avoided by appropriate modifications. In addition, active chemoprevention has become a major interventional approach following the epidemiological observation of a beneficial effect of nonsteroidal anti-inflammatory drugs (NSAIDs) in colon cancer prevention. This is chiefly due to the inhibition of the cyclooxygenase (COX) enzymes. The COX enzymatic system includes two isoenzymes, COX-1 and COX-2, that convert arachidonic acid to prostaglandins. COX-1 is constitutively expressed and synthesizes cytoprotective prostaglandins in the gastrointestinal tract. COX-2 is inducible by the oncogenes ras and scr and other cytokines; it is overexpressed in human cancer cells in which it stimulates cellular division and angiogenesis and inhibits apoptosis. NSAIDs restore apoptosis and decrease tumor mitogenesis and angiogenesis. Most cancer cells have been found to exhibit overexpression of COX-2. Epidemiological studies showed a lower risk of developing cancer of the colon, breast, esophagus, and stomach following the ingestion of NSAIDs. The use of NSAIDs in low dose was associated with a statistically significant decrease in the risk of adenomatous polyps and of overt colon cancer. The regressive effects of sulindac on foci of aberrant crypts in the colon (considered to be precursors of adenoma), and on adenocarcinoma of the colon, are of particular interest because this NSAID does not have an inhibitory effect on COX. This may support the view that the antineoplastic effect of NSAIDs may also be due to a mechanism other than COX-2 inhibition. In breast cancer, large cohort studies reported a 40 to 50% reduced risk of developing cancer, a smaller size of the primary tumor, and a reduction in the number of involved axillary lymph nodes. Similar findings have been reported in the esophagus and stomach, but not in gastric cardia adenocarcinoma. The recent development of selective COX-2 inhibitors resulted in better clinical tolerance than that associated with NSAIDs in general, with the absence of gastrointestinal side effects known to occur after the inhibition of COX-1. Encouraging results have been obtained with these new agents in familial adenomatous polyposis, colon, breast, and prostate cancer. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Moran, E M AD - Cancer Program (11-T), V.A. Medical Center, 5901 East Seventh Street, Long Beach, CA 90822, USA, edgar.moran@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 193 EP - 202 VL - 21 IS - 2 SN - 0731-8898, 0731-8898 KW - chemoprevention KW - epidemiology KW - man KW - Toxicology Abstracts KW - X 24250:Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18431518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Epidemiological+and+Clinical+Aspects+of+Nonsteroidal+Anti-inflammatory+Drugs+and+Cancer+Risks&rft.au=Moran%2C+E+M&rft.aulast=Moran&rft.aufirst=E&rft.date=2002-01-01&rft.volume=21&rft.issue=2&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Association between initial empirical therapy and decreased length of stay among veteran patients hospitalized with community acquired pneumonia AN - 18371462; 5348264 AB - This investigation assessed the impact of initial empirical antimicrobial therapy on the outcome of therapy for community acquired pneumonia (CAP) patients and on patients' length of stay (LOS) in the hospital. Hospital records for 165 patients with pneumonia admitted to the Edward Hines, Jr. VA Hospital between 1 October 1997, and 31 March 2000, were reviewed. Criteria for CAP were met for 92 of 165 patients. Comparisons were made between patients treated with azithromycin and with other parenteral antibiotics (the reference group). No statistical differences were observed between the treatment groups for the risk factors. The azithromycin group patients were slightly older with a mean age of 69 years versus 66 years (P = 0.23). Patients treated with parenteral azithromycin had on average, a shorter length of hospitalization namely 4.6 days compared with 9.7 days for patients treated with the other antibiotics (log-rank test, P = 0.0001). In order to make the two groups of patients more alike we considered patients' data set without intensive care unit (ICU) admissions. The conclusion was the same namely azithromycin monotherapy was associated with a decreased duration of hospital stay. JF - International Journal of Antimicrobial Agents AU - Lentino, J R AU - Krasnicka, B AD - Section of Infectious Diseases (111P), Medical Service, Cooperative Studies Program Coordinating Center, Edward Hines, Jr. VA Hospital, Hines, IL 60141, USA, joseph.lentino@med.va.gov Y1 - 2002/01// PY - 2002 DA - Jan 2002 SP - 61 EP - 66 VL - 19 IS - 1 SN - 0924-8579, 0924-8579 KW - azithromycin KW - Microbiology Abstracts B: Bacteriology KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18371462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Antimicrobial+Agents&rft.atitle=Association+between+initial+empirical+therapy+and+decreased+length+of+stay+among+veteran+patients+hospitalized+with+community+acquired+pneumonia&rft.au=Lentino%2C+J+R%3BKrasnicka%2C+B&rft.aulast=Lentino&rft.aufirst=J&rft.date=2002-01-01&rft.volume=19&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Antimicrobial+Agents&rft.issn=09248579&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Neuromuscular blockers in surgery and intensive care, Part 2. AN - 72411813; 11794954 AB - The historical development, pharmacology, pharmacodynamics, pharmacokinetics, clinical applications, pharmacologic basis for selection, adverse effects, and cost of neuromuscular blockers (NMBs) are discussed. The first NMB to be used was tubocurarine. During neurotransmission, acetylcholine is synthesized, stored in vesicles at the neuromuscular junction, released into the synapse, and bound to nicotinic receptors in the muscle end plate. For muscle contraction to occur, the impulse generated in a neuron's cell body must create an action potential that is chemically transmitted across the synapse. The postsynaptic nicotinic receptor at the neuromuscular junction is the major site of action of depolarizing and nondepolarizing NMBs. All NMBs have the potential for cross-reactivity at other nicotinic and muscarinic sites. Drug interactions most commonly occur between NMBs and inhalation anesthetics, certain antimicrobials, calcium-channel blockers, and anticholinesterases. When selecting an NMB, an agent's onset and duration of action must be considered. NMBs can be used on a short-term or long-term basis. Apart from cost, the choice of an NMB is made on the basis of its adverse-reaction profile, pharmacokinetics, and indications for use. Monitoring tools, their use, the rationale for their use, and the interpretation of the results they provide are unique. The patterns of peripheral nerve stimulation vary and elicit different characteristics of nondepolarizing neuromuscular blockade. The effectiveness of reversal agents is proportional to the degree of blockade. The mechanism of action of anticholinesterases involves inhibition of acetylcholinesterase. The expensive NMBs should be conserved for use in surgery, while the cheaper, long-acting [corrected] agents should be used in the intensive care unit. An understanding of the pharmacology, pharmacodynamics, and pharmacokinetics of NMBs will help health care providers gain expertise in the selection and use of these agents. JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - McManus, M C AD - School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, MA, USA. mcmanus.claire@boston.va.gov Y1 - 2001/12/15/ PY - 2001 DA - 2001 Dec 15 SP - 2381 EP - 2395 VL - 58 IS - 24 SN - 1079-2082, 1079-2082 KW - Cholinesterase Reactivators KW - 0 KW - Neuromuscular Blocking Agents KW - Neuromuscular Nondepolarizing Agents KW - Receptors, Drug KW - Succinylcholine KW - J2R869A8YF KW - Index Medicus KW - Humans KW - Neuromuscular Nondepolarizing Agents -- metabolism KW - Succinylcholine -- pharmacology KW - Monitoring, Physiologic KW - Succinylcholine -- metabolism KW - Succinylcholine -- therapeutic use KW - Succinylcholine -- adverse effects KW - Receptors, Drug -- metabolism KW - Neuromuscular Nondepolarizing Agents -- therapeutic use KW - Critical Illness KW - Cholinesterase Reactivators -- therapeutic use KW - Neuromuscular Nondepolarizing Agents -- pharmacology KW - Neuromuscular Nondepolarizing Agents -- adverse effects KW - Neuromuscular Blocking Agents -- adverse effects KW - Anesthesia KW - Neuromuscular Blocking Agents -- therapeutic use KW - Neuromuscular Blocking Agents -- metabolism KW - Critical Care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72411813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Neuromuscular+blockers+in+surgery+and+intensive+care%2C+Part+2.&rft.au=McManus%2C+M+C&rft.aulast=McManus&rft.aufirst=M&rft.date=2001-12-15&rft.volume=58&rft.issue=24&rft.spage=2381&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-12 N1 - Date created - 2002-01-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Am J Health Syst Pharm 2002 Jan 1;59(1):16 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential Regulation of Mouse Kidney Sodium-Dependent Transporters mRNA by Cadmium AN - 18226933; 5295265 AB - Chronic exposure to cadmium can result in renal glycosuria. Previously, we reported that cadmium reduced the relative abundance of the sodium-glucose cotransporter mRNA (Blumenthal et al., Toxicol. Appl. Pharmacol.149, 49-54, 1998). To investigate this phenomenon further, we isolated full-length cDNA clones encoding both high- and low-affinity sodium-dependent glucose transporters SGLT1 and SGLT2, respectively, from cultured mouse kidney cortical cells. We also amplified a fragment of another putative sodium-glucose cotransporter with homology to the known SAAT1 /pSGLT2 or SGLT3 from our cultured cells and named it SGLT3. In order to examine the effect of cadmium on these transporters, primary cultures of mouse kidney cortical cells were exposed to micromolar concentrations of cadmium for 24 h and levels of SGLT1, SGLT2, and SGLT3 mRNA were determined by semiquantitative RT-PCR. Five to 10 mu M of cadmium inhibited sodium-dependent uptake of the glucose analog, alpha -methyl -glucopyranoside and progressively reduced the level of SGLT1. Cadmium also inhibited SGLT2 mRNA by 37%, but no further decline was observed at concentrations of cadmium greater than 5 mu M. While cadmium inhibited SGLT1 and SGLT2, it significantly stimulated the expression of SGLT3 by fivefold. These results imply that individual sodium-glucose cotransporter mRNA species are not regulated in a similar fashion. In addition, the isolation of three separate SGLT species from these cultures suggests that, in addition to SGLT1 and SGLT2, glucose reabsorption by renal epithelial cells might involve additional glucose transporters such as SGLT3. [copy ]2001 Elsevier Science. JF - Toxicology and Applied Pharmacology AU - Tabatabai, N M AU - Blumenthal, S S AU - Lewand, D L AU - Petering, D H AD - Department of Medicine, Medical College of Wisconsin, Section of Nephrology/111K, Zablocki Veterans Administration Medical Center, 5000 West National Avenue, Milwaukee, Wisconsin, 53295, ssblumen@mcw.edu Y1 - 2001/12/15/ PY - 2001 DA - 2001 Dec 15 SP - 163 EP - 173 PB - Academic Press VL - 177 IS - 3 SN - 0041-008X, 0041-008X KW - chronic toxicity KW - SGLT1 protein KW - SGLT2 protein KW - SGLT3 protein KW - glucose transport KW - sodium transport KW - Toxicology Abstracts KW - Kidney KW - Cadmium KW - mRNA KW - X 24162:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18226933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Differential+Regulation+of+Mouse+Kidney+Sodium-Dependent+Transporters+mRNA+by+Cadmium&rft.au=Tabatabai%2C+N+M%3BBlumenthal%2C+S+S%3BLewand%2C+D+L%3BPetering%2C+D+H&rft.aulast=Tabatabai&rft.aufirst=N&rft.date=2001-12-15&rft.volume=177&rft.issue=3&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1006%2Ftaap.2001.9321 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - mRNA; Kidney; Cadmium DO - http://dx.doi.org/10.1006/taap.2001.9321 ER - TY - JOUR T1 - Chlamydia pneumoniae and Chronic Skin Wounds: A Focused Review AN - 907161550; 14934895 AB - The genus, Chlamydophilia, as obligate intracellular pathogens, induce chronic scarring in humans. Chlamydia pneumoniae, a common cause of pneumonia, infects endothelial cells and circulating macrophages. Evidence that C. pneumoniae is an opportunistic pathogen in chronic skin ulcers and other inflammatory skin conditions analogous to its role in atherosclerosis is reviewed.Journal of Investigative Dermatology Symposium Proceedings (2001) 6, 233-237; doi:10.1046/j.0022-202x.2001.00050.x JF - Journal of Investigative Dermatology Symposium Proceedings AU - King, Lloyd E AU - Stratton, Charles W AU - Mitchell, William M AD - *Department of Medicine (Dermatology), Nashville Veterans Administration Medical Centers, Nashville, Tennessee, U.S.A. Y1 - 2001/12// PY - 2001 DA - Dec 2001 SP - 233 EP - 237 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 6 IS - 3 SN - 1087-0024, 1087-0024 KW - Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Skin KW - Dermatology KW - Pathogens KW - Arteriosclerosis KW - Inflammation KW - Opportunist infection KW - Wounds KW - Endothelial cells KW - Ulcers KW - Reviews KW - Chlamydophila pneumoniae KW - Pneumonia KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907161550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Investigative+Dermatology+Symposium+Proceedings&rft.atitle=Chlamydia+pneumoniae+and+Chronic+Skin+Wounds%3A+A+Focused+Review&rft.au=King%2C+Lloyd+E%3BStratton%2C+Charles+W%3BMitchell%2C+William+M&rft.aulast=King&rft.aufirst=Lloyd&rft.date=2001-12-01&rft.volume=6&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Journal+of+Investigative+Dermatology+Symposium+Proceedings&rft.issn=10870024&rft_id=info:doi/10.1046%2Fj.0022-202x.2001.00050.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Macrophages; Endothelial cells; Skin; Ulcers; Reviews; Dermatology; Arteriosclerosis; Pathogens; Pneumonia; Wounds; Opportunist infection; Inflammation; Chlamydophila pneumoniae DO - http://dx.doi.org/10.1046/j.0022-202x.2001.00050.x ER - TY - JOUR T1 - Determination of ototoxicity of common otic drops using isolated cochlear outer hair cells. AN - 85365589; pmid-11802005 AB - Otic drops are commonly used not only for otitis externa, but also for otorrhea in the presence of tympanostomy tubes or tympanic membrane perforations. Many studies have demonstrated the ototoxicity of common otic preparations such as Cortisporin otic drops (Monarch Pharmaceuticals, Bristol, TN). The purpose of this study was to assess the relative ototoxicity of common otic preparations by direct exposure to isolated cochlear outer hair cells (OHCs).OHCs from adult chinchilla cochlea were exposed to standard bathing solution (control), acetic acid, Acetasol HC (Alpharma USPD Inc., Baltimore, MD), Gentacidin (CIBA Vision Ophthalmics, Atlanta, GA), and Tobradex (Alcon, Fort Worth, TX). The cells were observed using an inverted microscope, and the images were recorded in digital still-frame and video, and analyzed on the Image Pro-Plus 3.0 program (Media Cybernetics, Silver Spring, MD).As measured by time to cell death and change in morphology of OHCs, acetic acid with or without hydrocortisone was most toxic to OHCs. Cortisporin was more cytotoxic than gentamicin and Tobradex. JF - The Laryngoscope AU - Jinn, T H AU - Kim, P D AU - Russell, P T AU - Church, C A AU - John, E O AU - Jung, T T AD - Division of Otolaryngology--Head and Neck Surgery, Department of Surgery, Loma Linda University School of Medicine and Jerry L Pettis Memorial Veterans Administration Hospital, Loma Linda, California, USA. Y1 - 2001/12// PY - 2001 DA - Dec 2001 SP - 2105 EP - 2108 VL - 111 IS - 12 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - *Acetic Acid: toxicity KW - Administration, Topical KW - Animals KW - Cell Size: drug effects KW - Cell Survival: drug effects KW - Cells, Cultured KW - Chinchilla KW - Drug Combinations KW - *Gentamicins: toxicity KW - *Hair Cells, Auditory, Outer: drug effects KW - Hair Cells, Auditory, Outer: ultrasonography KW - *Hydrocortisone: toxicity KW - *Neomycin: toxicity KW - *Polymyxin B: toxicity KW - *Tobramycin: toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85365589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Determination+of+ototoxicity+of+common+otic+drops+using+isolated+cochlear+outer+hair+cells.&rft.au=Jinn%2C+T+H%3BKim%2C+P+D%3BRussell%2C+P+T%3BChurch%2C+C+A%3BJohn%2C+E+O%3BJung%2C+T+T&rft.aulast=Jinn&rft.aufirst=T&rft.date=2001-12-01&rft.volume=111&rft.issue=12&rft.spage=2105&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Differential effects of bacterial toxins on mitogenic actions of sodium fluoride and those of aluminum fluoride in human TE85 osteosarcoma cells AN - 815538267; 13863391 AB - This study compared the effects of cholera toxin (CTX) and pertussis toxin (PTX) on the actions of sodium fluoride (NaF) and those of aluminum fluoride (AlF sub(3)) on cell proliferation and differentiation, as well as tyrosine phosphorylation level of MAP kinase (MAPK) in human bone cells. NaF and AlF sub(3) each significantly stimulated the proliferation of human TE85 osteosarcoma cells, increased cellular alkaline phosphatase (ALP) activity, and increased MAPK tyrosine phosphorylation level. CTX completely blocked the bone cell anabolic activities of both NaF and AlF sub(3). While PTX (2 ng/ml) inhibited the bone cell actions of NaF, it had no significant effect on those of AlF sub(3). Both CTX and PTX completely blocked the stimulatory action of AlF sub(3) on MAPK tyrosine phosphorylation, but neither toxin had an effect on the action of NaF on MAPK tyrosine phosphorylation. In conclusion, PTX and CTX had contrasting effects on the anabolic bone cell actions of NaF and AlF sub(3) actions. These findings argue against the hypothesis that the osteogenic activity of NaF is mediated via the formation of AlF sub(3) in human TE85 osteosarcoma cells. JF - Molecular and Cellular Biochemistry AU - Hashimoto, Hideki AU - Lau, K-HWilliam AD - Department of Medicine, Loma Linda University, USA, laub@lom.med.va.gov Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 91 EP - 98 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 228 IS - 1-2 SN - 0300-8177, 0300-8177 KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts; Calcium & Calcified Tissue Abstracts KW - Bacteria KW - MAP kinase KW - Tyrosine KW - pertussis toxin KW - Collagen KW - Protein-tyrosine-phosphatase KW - Bone KW - Differentiation KW - Sodium fluoride KW - Alkaline phosphatase KW - Osteosarcoma cells KW - Phosphorylation KW - Cholera toxin KW - Fluoride KW - Aluminum KW - Cell proliferation KW - X 24370:Natural Toxins KW - J 02330:Biochemistry KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815538267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biochemistry&rft.atitle=Differential+effects+of+bacterial+toxins+on+mitogenic+actions+of+sodium+fluoride+and+those+of+aluminum+fluoride+in+human+TE85+osteosarcoma+cells&rft.au=Hashimoto%2C+Hideki%3BLau%2C+K-HWilliam&rft.aulast=Hashimoto&rft.aufirst=Hideki&rft.date=2001-12-01&rft.volume=228&rft.issue=1-2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biochemistry&rft.issn=03008177&rft_id=info:doi/10.1023%2FA%3A1013320625846 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - MAP kinase; Tyrosine; Protein-tyrosine-phosphatase; Collagen; pertussis toxin; Bone; Sodium fluoride; Differentiation; Alkaline phosphatase; Phosphorylation; Osteosarcoma cells; Fluoride; Cholera toxin; Aluminum; Cell proliferation; Bacteria DO - http://dx.doi.org/10.1023/A:1013320625846 ER - TY - JOUR T1 - Variability in the assessment of adverse events in a multicenter clinical trial. AN - 72417566; 11813935 AB - Consistent documentation, characterization, and evaluation of adverse events (AEs) are needed during multicenter clinical trials to ensure accuracy of data reported to the US Food and Drug Administration and in the medical literature. The purpose of this study was to identify and characterize variations in the assessment of AEs by clinical trial personnel. During the annual meeting of personnel from a multicenter, controlled clinical trial of an investigational new drug treatment for opioid dependence, an oral presentation of procedures for AE data collection was given to 25 principal investigators and ancillary study personnel who assessed AEs for the study. A post-test using 3 hypothetical AE cases in which AEs were categorized by type of reaction, relatedness to study drug, severity, action taken, and outcome was completed by study participants. Cases and expected responses were reviewed for content and validity by clinical research pharmacists who were not involved with the study. The level of agreement with expected responses was assessed using McNemar symmetry chi-square tests. Assessments of type of AE, relatedness to study drug, and severity were less frequently aligned with expected responses than were action taken and outcome (P < 0.013). Less consistency with expected responses was found in I case than in the other 2, suggesting that certain types of AEs may be more difficult to assess. There was considerable variability in categorization of AEs in an exercise following training for AE data collection. Type of report, relatedness, and severity were found to have more variability in reporting than did action taken or outcome. The results suggest that unless data are gathered to verify reliability of reporting, subcategorization of AE data should be undertaken cautiously. Further research is needed regarding methods for improving consistency in reporting of AEs. JF - Clinical therapeutics AU - Raisch, D W AU - Troutman, W G AU - Sather, M R AU - Fudala, P J AD - Department of Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, College of Pharmacy, University of New Mexico, Albuquerque 87106, USA. dennis.raisch@csp.research.med.va.gov Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 2011 EP - 2020 VL - 23 IS - 12 SN - 0149-2918, 0149-2918 KW - Index Medicus KW - Documentation KW - Reproducibility of Results KW - Humans KW - Research Personnel KW - Multicenter Studies as Topic KW - Drug-Related Side Effects and Adverse Reactions KW - Clinical Trials as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72417566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+therapeutics&rft.atitle=Variability+in+the+assessment+of+adverse+events+in+a+multicenter+clinical+trial.&rft.au=Raisch%2C+D+W%3BTroutman%2C+W+G%3BSather%2C+M+R%3BFudala%2C+P+J&rft.aulast=Raisch&rft.aufirst=D&rft.date=2001-12-01&rft.volume=23&rft.issue=12&rft.spage=2011&rft.isbn=&rft.btitle=&rft.title=Clinical+therapeutics&rft.issn=01492918&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-12 N1 - Date created - 2002-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cyclooxygenase-2 selective inhibitors and the kidney. AN - 72409163; 11805541 AB - Cyclooxygenases (COX) are the target of non-steroidal anti-inflammatory drugs (NSAIDs) which exert their therapeutic effect by blocking COX's capacity to metabolize arachidonate to a series of biologically active fatty acids, designated prostaglandins. NSAID use is associated with two major tonicities: gastrointestinal bleeding and renal dysfunction. In the setting of significant physiologic stress, renal function becomes dependent upon prostaglandins and NSAID use may be associated with acute deterioration of renal function, including development of sodium retention, edema, hypertension, hyperkalemia, and or papillary necrosis. Two isoforms, COX1 and COX2, have been identified. They are products of distinct genes and their expression is under different regulatory control. Both COX1 and COX2 are highly expressed in the kidney and both are inhibited by conventional NSAIDs. Accumulating data using recently developed selective COX2 inhibitors suggest that while these agents spare the gastrointestinal tract they have similar renal effects as non-selective NSAIDs. Therefore, caution should be taken when prescribing selective COX2 inhibitor to patients, especially to patients with predisposed physiologic stress. JF - Current opinion in critical care AU - Breyer, M D AU - Hao, C AU - Qi, Z AD - Division of Nephrology and Department of Medicine, Veterans Administration Medical Center and Vanderbilt University, Nashville, Tennessee 37232, USA. matthew.breyer@mcmail.vanderbilt.edu Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 393 EP - 400 VL - 7 IS - 6 SN - 1070-5295, 1070-5295 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase 2 Inhibitors KW - Cyclooxygenase Inhibitors KW - Isoenzymes KW - Membrane Proteins KW - Prostaglandins KW - Cyclooxygenase 1 KW - EC 1.14.99.1 KW - Cyclooxygenase 2 KW - PTGS1 protein, human KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Ptgs1 protein, mouse KW - Ptgs1 protein, rat KW - Index Medicus KW - Animals KW - Humans KW - Juxtaglomerular Apparatus -- metabolism KW - Prostaglandins -- biosynthesis KW - Rabbits KW - Mice KW - Rats KW - Hyperkalemia -- etiology KW - Hypertension -- etiology KW - Prostaglandin-Endoperoxide Synthases -- biosynthesis KW - Isoenzymes -- antagonists & inhibitors KW - Cyclooxygenase Inhibitors -- adverse effects KW - Kidney -- metabolism KW - Isoenzymes -- biosynthesis KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Kidney -- drug effects KW - Kidney Diseases -- chemically induced KW - Cyclooxygenase Inhibitors -- pharmacology KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72409163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+critical+care&rft.atitle=Cyclooxygenase-2+selective+inhibitors+and+the+kidney.&rft.au=Breyer%2C+M+D%3BHao%2C+C%3BQi%2C+Z&rft.aulast=Breyer&rft.aufirst=M&rft.date=2001-12-01&rft.volume=7&rft.issue=6&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+critical+care&rft.issn=10705295&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-22 N1 - Date created - 2002-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anaphylactoid reaction to etomidate: report of a case. AN - 72377275; 11755328 AB - We report an anaphylactoid reaction to etomidate twice in a 60-year-old male with coronary artery disease and peripheral vascular disease. Following the first anaphylactoid reaction, the patient developed myocardial infarction. In addition, the patient's blood was moderately positive for latex antibodies, which made the differential diagnosis difficult. We concluded that the patient had anaphylactoid reaction to etomidate due to the temporal relationship to induction with the drug. The patient did not manifest similar reaction to other induction drugs used for other surgeries. The patient recovered from both incidents of anaphylactoid reaction to etomidate following intravenous administration of epinephrine and fluids. JF - Journal of clinical anesthesia AU - Moorthy, S S AU - Laurent, B AU - Pandya, P AU - Fry, V AD - Richard L. Roudebush Veterans Administration Medical Center, and Department of Anesthesia, Indiana University Medical Center, Indianapolis, IN 46202, USA. sreenivasa.moorthy@med.va.gov Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 582 EP - 584 VL - 13 IS - 8 SN - 0952-8180, 0952-8180 KW - Anesthetics, Intravenous KW - 0 KW - Etomidate KW - Z22628B598 KW - Index Medicus KW - Latex Hypersensitivity -- diagnosis KW - Myocardial Infarction -- etiology KW - Diagnosis, Differential KW - Latex Hypersensitivity -- complications KW - Humans KW - Middle Aged KW - Intraoperative Complications KW - Male KW - Anaphylaxis -- drug therapy KW - Anaphylaxis -- chemically induced KW - Drug Hypersensitivity -- etiology KW - Anaphylaxis -- diagnosis KW - Anesthetics, Intravenous -- adverse effects KW - Etomidate -- adverse effects KW - Drug Hypersensitivity -- complications KW - Drug Hypersensitivity -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72377275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+anesthesia&rft.atitle=Anaphylactoid+reaction+to+etomidate%3A+report+of+a+case.&rft.au=Moorthy%2C+S+S%3BLaurent%2C+B%3BPandya%2C+P%3BFry%2C+V&rft.aulast=Moorthy&rft.aufirst=S&rft.date=2001-12-01&rft.volume=13&rft.issue=8&rft.spage=582&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+anesthesia&rft.issn=09528180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-31 N1 - Date created - 2001-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Justification for a new cohort study of people aging with and without HIV infection. AN - 72370271; 11750202 AB - This supplement contains a series of papers supporting the justification, design, and implementation of a longitudinal cohort study of an aging HIV-positive and HIV-negative veteran population called the Veterans Aging Cohort Study (VACS). Although the papers cover a wide range of topics and several papers address methodologic issues not unique to a study of aging veterans, all are motivated by a unifying set of assumptions. Specifically: (a) HIV/AIDS is a chronic disease in an aging population; (b) conditions among HIV-positive and -negative patients in care have overlapping etiologies; (c) individuals with pre-existing organ injury are at increased risk for iatrogenic injury; (d) cohort studies are uniquely suited to the study of chronic disease complicated by aging, comorbid conditions, drug toxicities, and substance use/abuse; (e) VACS is well positioned to study HIV as a chronic disease in an aging population. JF - Journal of clinical epidemiology AU - Justice, A C AU - Landefeld, C S AU - Asch, S M AU - Gifford, A L AU - Whalen, C C AU - Covinsky, K E AD - Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, University Drive C 11E-124 (130-U), Pittsburgh, PA 15240, USA. Amy.Justice@med.va.gov Y1 - 2001/12// PY - 2001 DA - December 2001 SP - S3 EP - S8 VL - 54 Suppl 1 SN - 0895-4356, 0895-4356 KW - Index Medicus KW - Humans KW - Chronic Disease KW - Longitudinal Studies KW - HIV Seronegativity KW - United States -- epidemiology KW - Research Design KW - HIV Seropositivity -- epidemiology KW - Comorbidity KW - Veterans KW - Aging -- physiology KW - HIV Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72370271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+epidemiology&rft.atitle=Justification+for+a+new+cohort+study+of+people+aging+with+and+without+HIV+infection.&rft.au=Justice%2C+A+C%3BLandefeld%2C+C+S%3BAsch%2C+S+M%3BGifford%2C+A+L%3BWhalen%2C+C+C%3BCovinsky%2C+K+E&rft.aulast=Justice&rft.aufirst=A&rft.date=2001-12-01&rft.volume=54+Suppl+1&rft.issue=&rft.spage=S3&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+epidemiology&rft.issn=08954356&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-29 N1 - Date created - 2001-12-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Symptom factor analysis, clinical findings, and functional status in a population-based case control study of Gulf War unexplained illness. AN - 72365819; 11765674 AB - Few epidemiological studies have been conducted that have incorporated clinical evaluations of Gulf War veterans with unexplained health symptoms and healthy controls. We conducted a mail survey of 2022 Gulf War veterans residing in the northwest United States and clinical examinations on a subset of 443 responders who seemed to have unexplained health symptoms or were healthy. Few clinical differences were found between cases and controls. The most frequent unexplained symptoms were cognitive/psychological, but significant overlap existed with musculoskeletal and fatigue symptoms. Over half of the veterans with unexplained musculoskeletal pain met the criteria for fibromyalgia, and a significant portion of the veterans with unexplained fatigue met the criteria for chronic fatigue syndrome. Similarities were found in the clinical interpretation of unexplained illness in this population and statistical factor analysis performed by this study group and others. JF - Journal of occupational and environmental medicine AU - Bourdette, D N AU - McCauley, L A AU - Barkhuizen, A AU - Johnston, W AU - Wynn, M AU - Joos, S K AU - Storzbach, D AU - Shuell, T AU - Sticker, D AD - Portland Veterans Affairs Medical Center, Department of Neurology, Mailcode P-3-NEURO, 3710 SW US Veteran's Hospital Road, Portland, OR 97201, USA. Dennis.Bourdette@med.va.gov Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 1026 EP - 1040 VL - 43 IS - 12 SN - 1076-2752, 1076-2752 KW - Index Medicus KW - Warfare KW - Fibromyalgia -- etiology KW - Humans KW - Health Surveys KW - Fatigue Syndrome, Chronic -- etiology KW - Adult KW - Surveys and Questionnaires KW - Case-Control Studies KW - United States -- epidemiology KW - Middle East KW - Male KW - Occupational Exposure -- statistics & numerical data KW - Persian Gulf Syndrome -- complications KW - Veterans -- statistics & numerical data KW - Persian Gulf Syndrome -- epidemiology KW - Occupational Exposure -- adverse effects KW - Persian Gulf Syndrome -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72365819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Symptom+factor+analysis%2C+clinical+findings%2C+and+functional+status+in+a+population-based+case+control+study+of+Gulf+War+unexplained+illness.&rft.au=Bourdette%2C+D+N%3BMcCauley%2C+L+A%3BBarkhuizen%2C+A%3BJohnston%2C+W%3BWynn%2C+M%3BJoos%2C+S+K%3BStorzbach%2C+D%3BShuell%2C+T%3BSticker%2C+D&rft.aulast=Bourdette&rft.aufirst=D&rft.date=2001-12-01&rft.volume=43&rft.issue=12&rft.spage=1026&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-11 N1 - Date created - 2001-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prostaglandin inhibitors and the chemoprevention of noncolonic malignancy. AN - 72357594; 11764539 AB - Much has been learned about the role of NSAIDs as cancer preventives through epidemiologic and experimental studies. The pathways of carcinogenesis in the gastrointestinal tract are initiated by many different genetic, environmental, infective, and lifestyle factors. It is possible that the final common pathway of all these malignancies may have some common features. It is conceivable that head and neck, esophageal, gastric, and colorectal epithelial carcinogenesis all are influenced by or require COX-2 up-regulation as a step toward transformation. Intuitively, it is possible that selective COX-2 inhibitors may have a preventive role in all these epithelial malignancies. Today's challenge is to translate this information into clinical trials to define what role, if any, COX inhibition might play in the prevention of these malignancies. JF - Gastroenterology clinics of North America AU - Krishnan, K AU - Brenner, D E AD - Division of Hematology and Oncology, Department of Internal Medicine, James H. Quillen Veterans Administration Medical Center, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA. krishnak@etsu.edu Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 981 EP - 1000 VL - 30 IS - 4 SN - 0889-8553, 0889-8553 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase 2 Inhibitors KW - Cyclooxygenase Inhibitors KW - Isoenzymes KW - Membrane Proteins KW - Prostaglandin Antagonists KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Index Medicus KW - Isoenzymes -- antagonists & inhibitors KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Humans KW - Disease Progression KW - Prostaglandin Antagonists -- therapeutic use KW - Esophageal Neoplasms -- prevention & control KW - Cyclooxygenase Inhibitors -- therapeutic use KW - Adenocarcinoma -- physiopathology KW - Carcinoma, Squamous Cell -- physiopathology KW - Esophageal Neoplasms -- physiopathology KW - Carcinoma, Squamous Cell -- prevention & control KW - Barrett Esophagus -- physiopathology KW - Stomach Neoplasms -- physiopathology KW - Stomach Neoplasms -- prevention & control KW - Adenocarcinoma -- prevention & control KW - Barrett Esophagus -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72357594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology+clinics+of+North+America&rft.atitle=Prostaglandin+inhibitors+and+the+chemoprevention+of+noncolonic+malignancy.&rft.au=Krishnan%2C+K%3BBrenner%2C+D+E&rft.aulast=Krishnan&rft.aufirst=K&rft.date=2001-12-01&rft.volume=30&rft.issue=4&rft.spage=981&rft.isbn=&rft.btitle=&rft.title=Gastroenterology+clinics+of+North+America&rft.issn=08898553&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-13 N1 - Date created - 2001-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuromuscular blockers in surgery and intensive care, Part 1. AN - 72355896; 11763807 AB - The historical development, pharmacology, pharmacodynamics, pharmacokinetics, clinical applications, pharmacologic basis for selection, adverse effects, and cost of neuromuscular blockers (NMBs) are discussed. The first NMB to be used was tubocurarine. During neurotransmission, acetylcholine is synthesized, stored in vesicles at the neuromuscular junction, released into the synapse, and bound to nicotinic receptors in the muscle end plate. For muscle contraction to occur, the impulse generated in a neuron's cell body must create an action potential that is chemically transmitted across the synapse. The postsynaptic nicotinic receptor at the neuromuscular junction is the major site of action of depolarizing and nondepolarizing NMBs. All NMBs have the potential for cross-reactivity at other nicotinic and muscarinic sites. Drug interactions most commonly occur between NMBs and inhalation anesthetics, certain antimicrobials, calcium-channel blockers, and anticholinesterases. When selecting an NMB, an agent's onset and duration of action must be considered. NMBs can be used on a short-term or long-term basis. Apart from cost, the choice of an NMB is made on the basis of its adverse-reaction profile, pharmacokinetics, and indications for use. Monitoring tools, their use, the rationale for their use, and the interpretation of the results they provide are unique. The patterns of peripheral nerve stimulation vary and elicit different characteristics of nondepolarizing neuromuscular blockade. The effectiveness of reversal agents is proportional to the degree of blockade. The mechanism of action of anticholinesterases involves inhibition of acetylcholinesterase. The expensive NMBs should be conserved for use in surgery, while the cheaper, long-acting [corrected] agents should be used in the intensive care unit. An understanding of the pharmacology, pharmacodynamics, and pharmacokinetics of NMBs will help health care providers gain expertise in the selection and use of these agents. JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - McManus, M C AD - School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, MA, USA. mcmanus.claire@boston.va.gov Y1 - 2001/12/01/ PY - 2001 DA - 2001 Dec 01 SP - 2287 EP - 2299 VL - 58 IS - 23 SN - 1079-2082, 1079-2082 KW - Neuromuscular Blocking Agents KW - 0 KW - Index Medicus KW - Humans KW - Neuromuscular Blocking Agents -- adverse effects KW - Anesthesia KW - Neuromuscular Blocking Agents -- therapeutic use KW - Neuromuscular Blocking Agents -- pharmacokinetics KW - Neuromuscular Blocking Agents -- pharmacology KW - Critical Care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72355896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Neuromuscular+blockers+in+surgery+and+intensive+care%2C+Part+1.&rft.au=McManus%2C+M+C&rft.aulast=McManus&rft.aufirst=M&rft.date=2001-12-01&rft.volume=58&rft.issue=23&rft.spage=2287&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-05-07 N1 - Date created - 2001-12-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Am J Health Syst Pharm 2002 Jan 1;59(1):16 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Social support and abstinence from opiates and cocaine during opioid maintenance treatment. AN - 72285630; 11714591 AB - Social support may play an important role in helping drug users achieve abstinence; however these benefits may depend on the type of support experienced. In this prospective observational study, we examined the extent to which general and abstinence-specific support, both structural and functional, predicted opiate and cocaine abstinence in 128 opioid maintenance patients receiving either methadone or LAAM. A new multidimensional self-report instrument assessing abstinence-specific functional support was developed for the study. Previously validated measures were used to assess the remaining types of support. With baseline abstinence and other statistically important covariates adjusted, hierarchical logistic regression analyses demonstrated that the associations between social support at study baseline and biochemically confirmed abstinence 3 months later varied by type of support and by drug. Greater abstinence-specific structural support (operationalized as fewer drug users in the social network) and decreases in three types of negative abstinence-specific functional support (Complaints about Drug Use, Drug Exposure, and Demoralization) predicted cocaine, but not opiate abstinence. There were no effects for general support, whether structural or functional, on abstinence from either drug. Interventions that focus on modifying patients' abstinence-specific support may be helpful in reducing the high rates of cocaine use disorders in this population. JF - Drug and alcohol dependence AU - Wasserman, D A AU - Stewart, A L AU - Delucchi, K L AD - Department of Psychiatry, University of California, San Francisco, CA 94103, USA. david.wasserman@med.va.gov Y1 - 2001/12/01/ PY - 2001 DA - 2001 Dec 01 SP - 65 EP - 75 VL - 65 IS - 1 SN - 0376-8716, 0376-8716 KW - Analgesics, Opioid KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Methadone -- therapeutic use KW - Chi-Square Distribution KW - Humans KW - Aged KW - Substance Abuse Treatment Centers -- statistics & numerical data KW - Prospective Studies KW - Behavior Therapy KW - Logistic Models KW - Adult KW - Treatment Outcome KW - Analgesics, Opioid -- therapeutic use KW - Follow-Up Studies KW - Middle Aged KW - Statistics, Nonparametric KW - Female KW - Male KW - Opioid-Related Disorders -- psychology KW - Cocaine-Related Disorders -- psychology KW - Opioid-Related Disorders -- therapy KW - Cocaine-Related Disorders -- therapy KW - Social Support UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72285630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Social+support+and+abstinence+from+opiates+and+cocaine+during+opioid+maintenance+treatment.&rft.au=Wasserman%2C+D+A%3BStewart%2C+A+L%3BDelucchi%2C+K+L&rft.aulast=Wasserman&rft.aufirst=D&rft.date=2001-12-01&rft.volume=65&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-04 N1 - Date created - 2001-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A clinical review of non-age-related cataracts. AN - 71328346; 12363250 AB - A cataract is any opacity or partial loss of transparency of the lens, whether the absence of transparency is small or complete. Pupil dilation affords a view of a legion of internal variations and abnormalities of the human crystalline lens which often tell us about its events and insults, as well as when in the patient's life these might have occurred. In this article, we review the major non-age-related association of cataractogenesis with respect to metabolic, environmental, ocular-specific, infectious, dermatologic, retinal, and toxic etiologies. The data are presented from the clinical perspective of incidence for a given condition and cataract type. Two simplified summary reference sheets are provided: (1) frequency of occurrence vs. etiology and (2) cataract type vs. etiology (color-coded). The busy clinician can refer to both tools chair-side. The human body has numerous methods of signaling insults and abnormalities. As the crystalline lens is an important gauge of overall health, an argument can be made for routine dilation of all patients. This information is also essential for future neutraceutical and pharmaceutical therapeutic intervention. JF - Optometry (St. Louis, Mo.) AU - Richer, S P AU - Yonatan, E AU - Harper, C K AU - McNelis, M AU - Rudy, D R AU - Perdue, A AD - DVA Medical Center, North Chicago, Illinois 60064-3095, USA. stuart.richer@med.va.gov Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 767 EP - 778 VL - 72 IS - 12 SN - 1529-1839, 1529-1839 KW - Index Medicus KW - Environment KW - Eye Diseases -- complications KW - Humans KW - Dermatitis, Atopic -- complications KW - Metabolic Diseases -- complications KW - Incidence KW - Retinal Diseases -- complications KW - Infection -- complications KW - Cataract -- epidemiology KW - Cataract -- chemically induced KW - Cataract -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71328346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Optometry+%28St.+Louis%2C+Mo.%29&rft.atitle=A+clinical+review+of+non-age-related+cataracts.&rft.au=Richer%2C+S+P%3BYonatan%2C+E%3BHarper%2C+C+K%3BMcNelis%2C+M%3BRudy%2C+D+R%3BPerdue%2C+A&rft.aulast=Richer&rft.aufirst=S&rft.date=2001-12-01&rft.volume=72&rft.issue=12&rft.spage=767&rft.isbn=&rft.btitle=&rft.title=Optometry+%28St.+Louis%2C+Mo.%29&rft.issn=15291839&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-23 N1 - Date created - 2002-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prolonged Colonization with Vancomycin-Resistant Enterococcus faecium in Long-Term Care Patients and the Significance of "Clearance" AN - 18448344; 5427392 AB - Little is known about the persistence of colonization with vancomycin-resistant Enterococcus faecium (VRE) in the nononcologic, non-intensive care unit patient. We studied all patients who had VRE isolated on greater than or equal to 2 occasions of >1 year apart (Study A) and those who had been "cleared" of VRE colonization after 3 negative stool cultures (Study B). Twelve patients had stored VRE isolates recovered >1 year apart (Study A), and 58% of paired isolates were genotypically related according to pulsed field gel electrophoresis patterns. In Study B, stool samples were obtained weekly from 21 "cleared" patients for 5 weeks, which revealed that 24% were VRE positive. For these culture-positive patients, 72% of the cultures failed to detect VRE. Recent antibiotic use was significantly more common in the culture-positive patients, as compared with culture-negative patients (P = .003). Colonization with VRE may persist for years, even if the results of intercurrent surveillance stool and index site cultures are negative. Cultures for detection of VRE in stool samples obtained from patients declared "cleared" are insensitive. JF - Clinical Infectious Diseases AU - Baden, L R AU - Thiemke, W AU - Skolnik, A AU - Chambers, R AU - Strymish, J AU - Gold, H S AU - Moellering, RC Jr AU - Eliopoulos, G M AD - Division of Infectious Disease, Beth Israel Deaconess Medical Center, The Brockton/West Roxbury Veterans Administration Medical Center, Harvard Medical School, Boston, USA Y1 - 2001/11/15/ PY - 2001 DA - 2001 Nov 15 SP - 1654 EP - 1660 VL - 33 IS - 10 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18448344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Prolonged+Colonization+with+Vancomycin-Resistant+Enterococcus+faecium+in+Long-Term+Care+Patients+and+the+Significance+of+%22Clearance%22&rft.au=Baden%2C+L+R%3BThiemke%2C+W%3BSkolnik%2C+A%3BChambers%2C+R%3BStrymish%2C+J%3BGold%2C+H+S%3BMoellering%2C+RC+Jr%3BEliopoulos%2C+G+M&rft.aulast=Baden&rft.aufirst=L&rft.date=2001-11-15&rft.volume=33&rft.issue=10&rft.spage=1654&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Microinjection of bombesin into the ventrolateral reticular formation inhibits peripherally stimulated gastric acid secretion through spinal pathways in rats. AN - 72237011; 11684036 AB - Bombesin injected into the cisterna magna potently inhibits gastric acid secretion stimulated by intravenous infusion of pentagastrin. Sites in the medulla oblongata where bombesin acts to suppress gastric acid secretion were investigated in urethane-anesthetized rats with gastric cannula. Bombesin or vehicle was injected into the medullary parenchyma or intracisternally (i.c.) 60 min after the start of an intravenous pentagastrin infusion; gastric acid secretion was monitored every 10 min for 20 min before and 150 min after the start of pentagastrin. Bombesin (0.2, 0.6 or 6.2 pmol) microinjected into the ventrolateral reticular formation (VLRF) inhibited dose-dependently the net acid response to pentagastrin by 40.8+/-11.1, 75.4+/-12.8 and 96.7+/-19.4%, respectively, at the 40-50 min period after microinjection compared with the vehicle group. Bombesin action in the VLRF was long lasting (96% inhibition still observed at 90 min after 6.2 pmol), and completely abolished by cervical spinal cord transection at the C6 level. By contrast, bombesin injected i.c. at 0.2 or 0.6 pmol had no effect while at 6.2 pmol, there was a 79.0+/-3.9% peak inhibition of pentagastrin-stimulated acid secretion. Bombesin (6.2 pmol) injected into the dorsal motor nucleus reduced the acid response to pentagastrin by 29%. The parvicellular and gigantocellular reticular nuclei were not responsive to bombesin. These results indicate that bombesin acts in the VLRF to inhibit pentagastrin-stimulated gastric acid secretion through spinal pathways, suggesting a potential role of medullary VLRF area in the sympathetic control of gastric acid secretion. JF - Brain research AU - Ishikawa, T AU - Yang, H AU - Taché, Y AD - CURE: Digestive Diseases Research Center, Veterans Administration Greater Los Angeles Healthcare System, Department of Medicine, Digestive Diseases Division and Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 90073, USA. Y1 - 2001/11/09/ PY - 2001 DA - 2001 Nov 09 SP - 1 EP - 9 VL - 918 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Pentagastrin KW - EF0NX91490 KW - Bombesin KW - PX9AZU7QPK KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Pentagastrin -- pharmacology KW - Neural Inhibition -- drug effects KW - Gastric Mucosa -- innervation KW - Neural Inhibition -- physiology KW - Gastric Mucosa -- secretion KW - Male KW - Drug Interactions -- physiology KW - Injections, Intraventricular KW - Efferent Pathways -- metabolism KW - Spinal Cord -- metabolism KW - Sympathetic Nervous System -- drug effects KW - Medulla Oblongata -- cytology KW - Efferent Pathways -- cytology KW - Medulla Oblongata -- drug effects KW - Gastric Acid -- secretion KW - Reticular Formation -- drug effects KW - Sympathetic Nervous System -- cytology KW - Reticular Formation -- cytology KW - Spinal Cord -- drug effects KW - Sympathetic Nervous System -- metabolism KW - Bombesin -- pharmacology KW - Reticular Formation -- metabolism KW - Efferent Pathways -- drug effects KW - Medulla Oblongata -- metabolism KW - Spinal Cord -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72237011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Microinjection+of+bombesin+into+the+ventrolateral+reticular+formation+inhibits+peripherally+stimulated+gastric+acid+secretion+through+spinal+pathways+in+rats.&rft.au=Ishikawa%2C+T%3BYang%2C+H%3BTach%C3%A9%2C+Y&rft.aulast=Ishikawa&rft.aufirst=T&rft.date=2001-11-09&rft.volume=918&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-04 N1 - Date created - 2001-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of pepsin in acid injury to esophageal epithelium. AN - 85363562; pmid-11721751 AB - The development of reflux esophagitis in humans is a process resulting from esophageal exposure to refluxed gastric contents. There is no doubt that damage to the esophageal epithelium requires exposure to gastric acid; however, the role of refluxed pepsin as contributor to this damage seems to be underappreciated.The role of physiological concentrations of pepsin was examined in Ussing chambered rabbit esophageal epithelium and in cultured esophageal epithelial cells.The results of this investigation reaffirmed the ability of pepsin to increase the rate and degree of esophageal cell and tissue damage at acidic pH, although the range of activity was limited to pH < 3.0. Moreover, the increased rate of tissue damage by acidified pepsin rapidly (within 15 min) produced a lesion that was irreversible, whereas, in a similar time frame, acid alone produced a lesion that was completely reversible. This early lesion by acidified pepsin was localized by performance of mannitol fluxes in apparently undamaged esophageal epithelium on light microscopy to the intercellular junctional complex. Further acid produced similar degrees of cell killing as acidified pepsin at pH < 3.0 in rabbit esophageal epithelial cells in suspension but not when growing on coverslips or present within intact epithelium.These studies suggest that acidified pepsin plays a key role in the development of reflux esophagitis by producing an early irreversible lesion that results in an increase in paracellular permeability, which indirect evidence suggests is due to damage to the junctional complex. The irreversibility of the increase in paracellular permeability is likely to aid conversion of nonerosive to erosive damage to the epithelium by permitting luminal acid greater access to the basolateral membrane of esophageal epithelial cells, which is known to be acid permeable. JF - The American journal of gastroenterology AU - Tobey, N A AU - Hosseini, S S AU - Caymaz-Bor, C AU - Wyatt, H R AU - Orlando, G S AU - Orlando, R C AD - Department of Medicine, Tulane University School of Medicine and the Veterans Administration Medical Center, New Orleans, Louisiana 70112, USA. Y1 - 2001/11// PY - 2001 DA - Nov 2001 SP - 3062 EP - 3070 VL - 96 IS - 11 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Epithelial Cells: pathology KW - Epithelium: pathology KW - *Esophagus: pathology KW - Gastric Acid KW - *Pepsin A: physiology KW - Rabbits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85363562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=The+role+of+pepsin+in+acid+injury+to+esophageal+epithelium.&rft.au=Tobey%2C+N+A%3BHosseini%2C+S+S%3BCaymaz-Bor%2C+C%3BWyatt%2C+H+R%3BOrlando%2C+G+S%3BOrlando%2C+R+C&rft.aulast=Tobey&rft.aufirst=N&rft.date=2001-11-01&rft.volume=96&rft.issue=11&rft.spage=3062&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Ofloxacin: a probable cause of toxic epidermal necrolysis. AN - 72301225; 11724089 AB - To report a fatal case of toxic epidermal necrolysis in a man who was treated with oral ofloxacin for epididymitis. A 75-year-old white man received 23.6 grams of ofloxacin over a 51-day period for epididymitis. He experienced a severe skin reaction diagnosed as toxic epidermal necrolysis. The man died from complications related to toxic epidermal necrolysis. Toxic epidermal necrolysis is an infrequent, yet often fatal, severe, systemic, cutaneous disease most often the result of an adverse drug reaction. Fluoroquinolones have rarely been implicated in cases of toxic epidermal necrolysis. A MEDLINE search from 1966 to December 2000 revealed no reports of toxic epidermal necrolysis, erythema multiforme, or Stevens-Johnson syndrome due to ofloxacin therapy. However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given. This report rules out other causes of toxic epidermal necrolysis and implicates ofloxacin in what appears to be an atypical presentation of drug-induced toxic epidermal necrolysis. There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis. There are a few case reports of other fluoroquinolones that have been associated with toxic epidermal necrolysis. It is hoped that this case report creates awareness that ofloxacin-induced toxic epidermal necrolysis is possible. JF - The Annals of pharmacotherapy AU - Melde, S L AD - Central Texas Veterans Health Care System, Pharmacy Service, Temple 76504-7493, USA. Stephen.Melde@Med.VA.Gov Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 1388 EP - 1390 VL - 35 IS - 11 SN - 1060-0280, 1060-0280 KW - Anti-Infective Agents KW - 0 KW - Ofloxacin KW - A4P49JAZ9H KW - Index Medicus KW - Fatal Outcome KW - Humans KW - Aged KW - Male KW - Epididymitis -- drug therapy KW - Anti-Infective Agents -- therapeutic use KW - Anti-Infective Agents -- adverse effects KW - Stevens-Johnson Syndrome -- pathology KW - Ofloxacin -- adverse effects KW - Ofloxacin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72301225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Ofloxacin%3A+a+probable+cause+of+toxic+epidermal+necrolysis.&rft.au=Melde%2C+S+L&rft.aulast=Melde&rft.aufirst=S&rft.date=2001-11-01&rft.volume=35&rft.issue=11&rft.spage=1388&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-04-08 N1 - Date created - 2001-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Creativity and chronic disease. Ludwig van Beethoven (1770-1827). AN - 72259342; 11694466 JF - The Western journal of medicine AU - Wolf, P AD - University of California, San Diego, VA Medical Center, USA. paul.wolf@med.va.gov Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 298 VL - 175 IS - 5 SN - 0093-0415, 0093-0415 KW - Abridged Index Medicus KW - Index Medicus KW - van Beethoven KW - Liver Cirrhosis, Alcoholic -- history KW - Humans KW - History, 19th Century KW - Deafness -- history KW - Deafness -- etiology KW - Chronic Disease KW - Germany KW - Male KW - Music -- history KW - Osteitis Deformans -- history KW - Famous Persons KW - Osteitis Deformans -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72259342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Western+journal+of+medicine&rft.atitle=Creativity+and+chronic+disease.+Ludwig+van+Beethoven+%281770-1827%29.&rft.au=Wolf%2C+P&rft.aulast=Wolf&rft.aufirst=P&rft.date=2001-11-01&rft.volume=175&rft.issue=5&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=The+Western+journal+of+medicine&rft.issn=00930415&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-07 N1 - Date created - 2001-11-05 N1 - Date revised - 2017-01-13 N1 - People - van Beethoven N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - van Beethoven ER - TY - JOUR T1 - Screening for mental illness in a Veterans Affairs women's health clinic. AN - 72243957; 11684750 AB - This study examined the prevalence of self-reported mental illness and related impairment in social and occupational functioning among 209 female veterans enrolled in a primary care clinic. Ninety-four (45 percent) of the women screened positive for at least one psychiatric disorder, 46 (22 percent) for two or more coexisting psychiatric disorders, and 40 (19 percent) for only subthreshold disorders. The degree of self-reported impairment in social and occupational functioning was strongly related to the number of psychiatric diagnoses. Women who were under the age of 50 and those who had a service-connected disability were more likely to screen positive for a mental disorder. JF - Psychiatric services (Washington, D.C.) AU - Bader, G AU - Ragsdale, K G AU - Franchina, J J AD - VA medical Center, Salem, Virginia 24153, USA. geoffrey.bader@med.va.gov Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 1521 EP - 1522 VL - 52 IS - 11 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - United States KW - Aged, 80 and over KW - United States Department of Veterans Affairs KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Female KW - Comorbidity KW - Prevalence KW - Mass Screening KW - Women's Health Services KW - Mental Disorders -- prevention & control KW - Mental Disorders -- epidemiology KW - Occupational Diseases -- prevention & control KW - Veterans -- psychology KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72243957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Screening+for+mental+illness+in+a+Veterans+Affairs+women%27s+health+clinic.&rft.au=Bader%2C+G%3BRagsdale%2C+K+G%3BFranchina%2C+J+J&rft.aulast=Bader&rft.aufirst=G&rft.date=2001-11-01&rft.volume=52&rft.issue=11&rft.spage=1521&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-14 N1 - Date created - 2001-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nuclear medicine survey recommendations for a changing regulatory environment. AN - 72218098; 11669196 AB - The revision of 10 CFR 35 approved on 23 September 2000 and due for implementation in 2001, reduces the number of required radiation and contamination surveys to one ambient radiation survey each day when an administration requiring a written directive is used. This paper compares the current requirements in 10 CFR 35; the single, remaining, specific requirement in the revised part 35; the Nuclear Regulatory Commission's guidance in the proposed NUREG SR1556 and the general requirement for surveys to demonstrate compliance with 10 CFR 20. We also make recommendations on what periodic surveys are prudent. JF - Health physics AU - Vernig, P G AU - Schumacher, T A AD - Denver VA Medical Center, CO, USA. peter.vernig@med.va.gov Y1 - 2001/11// PY - 2001 DA - November 2001 SP - S70 EP - S74 VL - 81 IS - 5 Suppl SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Data Collection -- standards KW - Humans KW - Radiation Protection -- standards KW - Nuclear Medicine -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72218098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Nuclear+medicine+survey+recommendations+for+a+changing+regulatory+environment.&rft.au=Vernig%2C+P+G%3BSchumacher%2C+T+A&rft.aulast=Vernig&rft.aufirst=P&rft.date=2001-11-01&rft.volume=81&rft.issue=5+Suppl&rft.spage=S70&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tracking occupational doses of transient workers. AN - 72215668; 11669194 AB - A number of radioactive material licensees in the United States are unaware that they are required to track the occupational doses their radiation workers receive outside thieir facilities. As a result, these licensees may be cited for not tracking offsite occupational doses and quite possible for allowing some individuals to exceed the annual limits established by regulatory agencies. The accounting of occupational doses to "transient" workers is a difficult task. Unfortunately, written guidance to assist licensees on how to properly address this issue is not available. This paper was developed to raise awareness among radiation safety professionals of the need to establish effective measures to properly track transient worker exposures and maintain compliance with regulatory limits. JF - Health physics AU - Michel, R AU - Zorn, M J AD - VA San Diego Healthcare System, CA 92161, USA. rene.michel@med.va.gov Y1 - 2001/11// PY - 2001 DA - November 2001 SP - S65 EP - S66 VL - 81 IS - 5 Suppl SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Radiation Dosage KW - Risk Factors KW - Humans KW - Radiation Monitoring KW - Occupational Exposure KW - Radiation Protection -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72215668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Tracking+occupational+doses+of+transient+workers.&rft.au=Michel%2C+R%3BZorn%2C+M+J&rft.aulast=Michel&rft.aufirst=R&rft.date=2001-11-01&rft.volume=81&rft.issue=5+Suppl&rft.spage=S65&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Understanding patient preferences for the treatment of lupus nephritis with adaptive conjoint analysis. AN - 72210236; 11606874 AB - Incorporation of patient preferences into treatment decisions is an essential component of medical care. Conjoint analysis is an established method of eliciting consumer preferences in market research and is being increasingly used to study patient preferences for health care. To examine the value of Adaptive Conjoint Analysis (ACA), a unique method of performing conjoint analysis, and to evaluate patient treatment preferences. Interactive computer survey. Consecutive women (n = 103) with lupus followed in three community rheumatology practices. ACA was used to assess patients' relative preferences for specific cytotoxic medication characteristics, and to estimate the percentage of women preferring cyclophosphamide over azathioprine for different risk-benefit scenarios. All participants were able to complete the conjoint task in 14 +/-5 minutes. Of the nine medication characteristics studied, efficacy and risk for infection had the greatest impact on preference (each accounting for 20% of the variation in preferences), suggesting that patients consider differences in the risk for infection equally as important as differences in the probability of renal survival. Premenopausal women wanting more children were less likely to choose cyclophosphamide compared with their counterparts (56% vs. 80%, P = 0.04). Modest changes in the probability of renal survival or risk for major toxicity lowered the percentage of women preferring cyclophosphamide by more than 20%, irrespective of their desire for more children. ACA is a feasible method of assessing how patients consider specific medication characteristics and predicting treatment preferences under different risk-benefit scenarios. ACA may be a valuable tool to incorporate patient preferences into medical decision-making. JF - Medical care AU - Fraenkel, L AU - Bodardus, S AU - Wittnik, D R AU - Wittink, D R AD - Department of Medicine, Yale University, New Haven, Connecticut 06520-8031, USA. liana.fraenkel@med.va.gov Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 1203 EP - 1216 VL - 39 IS - 11 SN - 0025-7079, 0025-7079 KW - Antirheumatic Agents KW - 0 KW - Cyclophosphamide KW - 8N3DW7272P KW - Azathioprine KW - MRK240IY2L KW - Index Medicus KW - Azathioprine -- adverse effects KW - Azathioprine -- therapeutic use KW - Humans KW - Decision Making KW - Connecticut KW - Cyclophosphamide -- adverse effects KW - Cyclophosphamide -- therapeutic use KW - Adult KW - Treatment Outcome KW - Least-Squares Analysis KW - Middle Aged KW - Female KW - Survival Analysis KW - Models, Theoretical KW - Patient Satisfaction -- statistics & numerical data KW - Lupus Nephritis -- drug therapy KW - Patient Participation KW - Antirheumatic Agents -- adverse effects KW - Risk Assessment -- methods KW - Antirheumatic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72210236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=Understanding+patient+preferences+for+the+treatment+of+lupus+nephritis+with+adaptive+conjoint+analysis.&rft.au=Fraenkel%2C+L%3BBodardus%2C+S%3BWittnik%2C+D+R%3BWittink%2C+D+R&rft.aulast=Fraenkel&rft.aufirst=L&rft.date=2001-11-01&rft.volume=39&rft.issue=11&rft.spage=1203&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=00257079&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-05 N1 - Date created - 2001-10-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Med Care. 2003 May;41(5):574 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy. AN - 72191056; 11595644 AB - Cubilin is a 460-kDa multipurpose, multidomain receptor that contains an NH(2)-terminal 110-residue segment followed by 8 epidermal growth factor (EGF)-like repeats and a contiguous stretch (representing nearly 88% of its mass) of 27 CUB (initially found in complement components C1r/C1s, Uegf, and bone morphogenic protein-1) domains. Cubilin binds to intrinsic factor (IF)-cobalamin (cbl, vitamin B(12)) complex and promotes the ileal transport of cbl. The 460-kDa form of cubilin is the predominant form present in the apical brush-border membranes of rat intestine, kidney, and yolk sac, but a 230-kDa form of cubilin is also noted in the intestinal membranes. In thyroidectomized (TDX) rats, levels of intestinal brush-border IF-[(57)Co]-labeled cbl binding, 460-kDa cubilin protein levels and tissue (kidney) accumulation of cbl were reduced by approximately 70%. Immunoblot analysis using cubilin antiserum of intestinal total membranes from TDX rats revealed cubilin fragments with molecular masses of 200 and 300 kDa. Both of these bands, along with the 230-kDa band detected in the total membranes of control rats and unlike the 460-kDa form, failed to react with antiserum to EGF. Mucosal membrane cubilin associated with megalin was reduced from approximately 12% in control to approximately 4% in TDX rats, and this decreased association was not due to altered megalin levels. Thyroxine treatment of TDX rats resulted in reversal of all of these effects, including an increase to nearly 24% of cubilin associated with megalin. In vitro, megalin binding to cubilin occurred with the NH(2)-terminal region that contained the EGF-like repeats and CUB domains 1 and 2 but not with a downstream region that contained CUB domains 2-10. These studies indicate that thyroxine deficiency in rats results in decreased uptake and tissue accumulation of cbl caused mainly by destabilization and deficit of cubilin in the intestinal brush border. JF - American journal of physiology. Endocrinology and metabolism AU - Yammani, R R AU - Seetharam, S AU - Seetharam, B AD - Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin and Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin, 53226, USA. Y1 - 2001/11// PY - 2001 DA - November 2001 SP - E900 EP - E907 VL - 281 IS - 5 SN - 0193-1849, 0193-1849 KW - Cobalt Radioisotopes KW - 0 KW - Low Density Lipoprotein Receptor-Related Protein-2 KW - Receptors, Cell Surface KW - intrinsic factor-cobalamin receptor KW - Intrinsic Factor KW - 9008-12-2 KW - Edetic Acid KW - 9G34HU7RV0 KW - Vitamin B 12 KW - P6YC3EG204 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats KW - Immunoblotting KW - Animals KW - Drug Interactions KW - Electrophoresis, Polyacrylamide Gel KW - Microvilli -- metabolism KW - Intrinsic Factor -- metabolism KW - Vitamin B 12 -- metabolism KW - Calcium -- pharmacology KW - Protein Binding KW - Edetic Acid -- pharmacology KW - Receptors, Cell Surface -- metabolism KW - Intestines -- ultrastructure KW - Thyroidectomy KW - Low Density Lipoprotein Receptor-Related Protein-2 -- metabolism KW - Receptors, Cell Surface -- analysis KW - Intestines -- chemistry KW - Low Density Lipoprotein Receptor-Related Protein-2 -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72191056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Endocrinology+and+metabolism&rft.atitle=Cubilin+and+megalin+expression+and+their+interaction+in+the+rat+intestine%3A+effect+of+thyroidectomy.&rft.au=Yammani%2C+R+R%3BSeetharam%2C+S%3BSeetharam%2C+B&rft.aulast=Yammani&rft.aufirst=R&rft.date=2001-11-01&rft.volume=281&rft.issue=5&rft.spage=E900&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Endocrinology+and+metabolism&rft.issn=01931849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial. AN - 71291889; 11895000 AB - Both replication-incompetent and replication-selective adenoviruses are being developed for the treatment of cancer and other diseases. Concerns have been raised about the safety of intra-vascular adenovirus administration following a patient death on a clinical trial with a replication-defective adenovirus. In addition, the feasibility of vascular delivery to distant tumors has been questioned. dl1520 (ONYX-015) is a replication-selective adenovirus that has previously shown safety and antitumoral activity following intratumoral injection. This is the first report of intra-vascular administration with a genetically engineered, replication-selective virus. A phase I dose-escalation trial was performed in patients with liver-predominant gastrointestinal carcinoma (n = 11 total; primarily colorectal). dl1520 was infused into the hepatic artery at doses of 2 x 10(8)-2 x 10(1)2 particles for two cycles (days 1 and 8). Subsequent cycles of dl1520 were administered in combination with intravenous 5-fluorouracil (5-FU) and leucovorin. No dose-limiting toxicity, maximally tolerated dose or treatment-emergent clinical hepatotoxicity were identified following dl1520 infusion. Mild to moderate fever, rigors and fatigue were the most common adverse events. Antibody titers increased significantly in all patients. Viral replication was detectable in patients receiving the highest two doses. An objective response was demonstrated in combination with chemotherapy in a patient who was refractory to both 5-FU and dl1520 as single agents. Therefore, hepatic artery infusion of the attenuated adenovirus dl1520 was well-tolerated at doses resulting in infection, replication and chemotherapy-associated antitumoral activity. JF - Gene therapy AU - Reid, T AU - Galanis, E AU - Abbruzzese, J AU - Sze, D AU - Andrews, J AU - Romel, L AU - Hatfield, M AU - Rubin, J AU - Kirn, D AD - Palo Alto Veterans Administration Hospital and Stanford University Medical Center, CA, USA. Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 1618 EP - 1626 VL - 8 IS - 21 SN - 0969-7128, 0969-7128 KW - Adenovirus E1B Proteins KW - 0 KW - Antibodies, Viral KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Infusions, Intra-Arterial KW - Hepatic Artery KW - Combined Modality Therapy KW - Leucovorin -- administration & dosage KW - Humans KW - Aged KW - Genome, Viral KW - Gene Deletion KW - Antibodies, Viral -- blood KW - Fluorouracil -- administration & dosage KW - Virus Replication -- genetics KW - Adenovirus E1B Proteins -- genetics KW - Middle Aged KW - Maximum Tolerated Dose KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Male KW - Female KW - Genetic Therapy -- adverse effects KW - Liver Neoplasms -- therapy KW - Liver Neoplasms -- drug therapy KW - Colorectal Neoplasms -- therapy KW - Colorectal Neoplasms -- immunology KW - Genetic Therapy -- methods KW - Liver Neoplasms -- secondary KW - Adenoviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71291889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+therapy&rft.atitle=Intra-arterial+administration+of+a+replication-selective+adenovirus+%28dl1520%29+in+patients+with+colorectal+carcinoma+metastatic+to+the+liver%3A+a+phase+I+trial.&rft.au=Reid%2C+T%3BGalanis%2C+E%3BAbbruzzese%2C+J%3BSze%2C+D%3BAndrews%2C+J%3BRomel%2C+L%3BHatfield%2C+M%3BRubin%2C+J%3BKirn%2C+D&rft.aulast=Reid&rft.aufirst=T&rft.date=2001-11-01&rft.volume=8&rft.issue=21&rft.spage=1618&rft.isbn=&rft.btitle=&rft.title=Gene+therapy&rft.issn=09697128&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-04-25 N1 - Date created - 2002-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of penicillin-binding protein 4 in expression of vancomycin resistance among clinical isolates of oxacillin-resistant Staphylococcus aureus AN - 18236307; 5294748 AB - It has been reported that penicillin-binding protein 4 (PBP4) activity decreases when a vancomycin-susceptible Staphylococcus aureus isolate is passaged in vitro to vancomycin resistance. We analyzed the PBP profiles of four vancomycin intermediately susceptible S. aureus (VISA) clinical isolates and found that PBP4 was undetectable in three isolates (HIP 5827, HIP 5836, and HIP 6297) and markedly reduced in a fourth (Mu50). PBP4 was readily visible in five vancomycin-susceptible, oxacillin-resistant S. aureus (ORSA) isolates. The nucleotide sequences of the pbp4 structural gene and flanking sequences did not different between the VISA and vancomycin-susceptible isolates. Overproduction of PBP4 on a high-copy-number plasmid in the VISA isolates produced a two- to threefold decrease in vancomycin MICs. Inactivation of pbp4 by allelic replacement mutagenesis in three vancomycin-susceptible ORSA strains (COL, RN450M, and N315) led to a decrease in vancomycin susceptibility, an increase in highly vancomycin-resistant subpopulations, and decreased cell wall cross-linking by high-performance liquid chromatography analysis. Complementation of the COL mutant with plasmid-encoded pbp4 restored the vancomycin MIC and increased cell wall cross-linking. These data suggest that alterations in PBP4 expression are at least partially responsible for the VISA phenotype. JF - Antimicrobial Agents & Chemotherapy AU - Finan, JE AU - Archer, G L AU - Pucci, MJ AU - Climo, M W AD - Hunter Holmes McGuire Veterans Affairs Medical Center, 1201 Broad Rock Blvd., Section 111-C, Richmond, VA 23249, USA, michael.climo@med.va.gov Y1 - 2001/11// PY - 2001 DA - Nov 2001 SP - 3070 EP - 3075 VL - 45 IS - 11 SN - 0066-4804, 0066-4804 KW - isolates KW - pbp4 gene KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Oxacillin KW - penicillin-binding protein KW - Minimum inhibitory concentration KW - Mutagenesis KW - Vancomycin KW - Staphylococcus aureus KW - Antibiotic resistance KW - Genetic code KW - A 01064:Microbial resistance KW - J 02787:Peptide and protein antibiotics KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18236307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Role+of+penicillin-binding+protein+4+in+expression+of+vancomycin+resistance+among+clinical+isolates+of+oxacillin-resistant+Staphylococcus+aureus&rft.au=Finan%2C+JE%3BArcher%2C+G+L%3BPucci%2C+MJ%3BClimo%2C+M+W&rft.aulast=Finan&rft.aufirst=JE&rft.date=2001-11-01&rft.volume=45&rft.issue=11&rft.spage=3070&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Staphylococcus aureus; Vancomycin; penicillin-binding protein; Antibiotic resistance; Oxacillin; Minimum inhibitory concentration; Mutagenesis; Genetic code ER - TY - JOUR T1 - Argon plasma coagulation for rectal bleeding after prostate brachytherapy AN - 18219341; 5292405 AB - Purpose: To better define the efficacy and safety of argon plasma coagulation (APC), specifically for brachytherapy-related proctitis, we reviewed the clinical course of 7 patients treated for persistent rectal bleeding. Approximately 2-10% of prostate cancer patients treated with super(125)I or super(103)Pd brachytherapy will develop radiation proctitis. The optimum treatment for patients with persistent bleeding is unclear from the paucity of available data. Prior reports lack specific dosimetric information, and patients with widely divergent forms of radiation were grouped together in the analyses. Methods and Materials: Seven patients were treated with APC at the Veterans Affairs Puget Sound Health Care System and the University of Washington from 1997 to 1999 for persistent rectal bleeding due to prostate brachytherapy-related proctitis. Four patients received supplemental external beam radiation, delivered by a four-field technique. A single gastroenterologist at the Veterans Affairs Puget Sound Health Care System treated 6 of the 7 patients. If the degree of proctitis was limited, all sites of active bleeding were coagulated in symptomatic patients. An argon plasma coagulator electrosurgical system was used to administer treatments every 4-8 weeks as needed. The argon gas flow was set at 1.6 L/min, with an electrical power setting of 40-45 W. Results: The rectal V100 (the total rectal volume, including the lumen, receiving the prescription dose or greater) for the 7 patients ranged from 0.13 to 4.61 cc. Rectal bleeding was first noticed 3-18 months after implantation. APC (range 1-3 sessions) was performed 9-22 months after implantation. Five patients had complete resolution of their bleeding, usually within days of completing APC. Two patients had only partial relief from bleeding, but declined additional APC therapy. No patient developed clinically evident progressive rectal wall abnormalities after APC, (post-APC follow-up range 4-13 months). Conclusions: Most patients benefited from APC, and no cases of clinically evident progressive tissue destruction were noted. Although APC appears to be efficacious and safe in the setting of the rectal doses described here, caution is in order when contemplating APC for brachytherapy patients. JF - International Journal of Radiation Oncology, Biology, & Physics AU - Smith, S AU - Wallner, K AU - Dominitz, JA AU - Han, B AU - True, L AU - Sutlief, S AU - Billingsley, K AD - Department of Radiation Oncology (#174), Puget Sound Health Care System, Department of Veterans Affairs, 1660 S. Columbian Way, Seattle, WA 98108-15971, USA, kent.wallner@med.va.gov Y1 - 2001/11/01/ PY - 2001 DA - 2001 Nov 01 SP - 636 EP - 642 PB - Elsevier Science Inc. VL - 51 IS - 3 SN - 0360-3016, 0360-3016 KW - man KW - argon KW - prostate cancer KW - Toxicology Abstracts KW - Rectum KW - Bleeding KW - Radiotherapy KW - Proctitis KW - Side effects KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18219341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.atitle=Argon+plasma+coagulation+for+rectal+bleeding+after+prostate+brachytherapy&rft.au=Smith%2C+S%3BWallner%2C+K%3BDominitz%2C+JA%3BHan%2C+B%3BTrue%2C+L%3BSutlief%2C+S%3BBillingsley%2C+K&rft.aulast=Smith&rft.aufirst=S&rft.date=2001-11-01&rft.volume=51&rft.issue=3&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Side effects; Bleeding; Rectum; Radiotherapy; Proctitis ER - TY - JOUR T1 - Mutational effects at the subunit interfaces of human hemoglobin: evidence for a unique sensitivity of the T quaternary state to changes in the hinge region of the alpha 1 beta 2 interface. AN - 72184808; 11591155 AB - A set of variant human hemoglobins, each with an Ala or Gly substitution at a single residue, has been prepared, and the kinetics of their reactions with carbon monoxide have been measured. This reaction is rate-limited by the binding of the first CO to the deoxygenated T state of the protein. The magnitudes of the effects of the mutations on CO combination vary widely, and, with the exception of beta Y145, the residues with the most significant effects on these kinetics are found in the hinge region of the alpha 1 beta 2 interface. Mixed-metal hybrids, with zinc protoporphyrin IX in place of heme on both alpha or both beta subunits, were prepared for beta W37E, beta W37A, alpha Y140G, and alpha Y140A, hinge region variants causing large kinetic changes, and for beta Y145G. Such hybrids permit measurements of the kinetics of CO binding to only the heme-containing alpha or beta subunits within the unliganded hemoglobin tetramer. Mutations at beta 37 and alpha 140 have global effects on the T state, increasing the rates of CO binding to both types of subunits. Mutation of beta Y145 has a large effect on the beta subunits in the deoxygenated T state, but very little effect on the alpha subunits. Oxygen equilibria measurements on the crystalline T state of beta W37E also indicate large affinity increases in both subunits of this variant. The overall oxygen equilibria of the variant hemoglobins in solution are sensitive to numerous variables besides the properties of the deoxygenated T state. In contrast to CO combination kinetics, the residues whose alterations cause the largest changes in overall oxygen equilibria in solution are scattered seemingly randomly within the alpha 1 beta 2 interface. JF - Biochemistry AU - Noble, R W AU - Hui, H L AU - Kwiatkowski, L D AU - Paily, P AU - DeYoung, A AU - Wierzba, A AU - Colby, J E AU - Bruno, S AU - Mozzarelli, A AD - Department of Medicine, University at Buffalo, Veterans Administration Medical Center, Buffalo, NY 14215, USA. rnoble@acsu.buffalo.edu Y1 - 2001/10/16/ PY - 2001 DA - 2001 Oct 16 SP - 12357 EP - 12368 VL - 40 IS - 41 SN - 0006-2960, 0006-2960 KW - Hemoglobins KW - 0 KW - Protein Subunits KW - Protoporphyrins KW - Recombinant Proteins KW - zinc protoporphyrin KW - 15442-64-5 KW - Carbon Monoxide KW - 7U1EE4V452 KW - Globins KW - 9004-22-2 KW - Hemoglobin A KW - 9034-51-9 KW - Iron KW - E1UOL152H7 KW - Zinc KW - J41CSQ7QDS KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Models, Molecular KW - Oxygen -- metabolism KW - Dimerization KW - Hemoglobin A -- chemistry KW - Humans KW - Globins -- genetics KW - Iron -- chemistry KW - Hemoglobin A -- metabolism KW - Recombinant Proteins -- genetics KW - Zinc -- chemistry KW - Globins -- chemistry KW - Protein Structure, Quaternary KW - Mutagenesis, Site-Directed KW - Recombinant Proteins -- metabolism KW - Kinetics KW - In Vitro Techniques KW - Recombinant Proteins -- chemistry KW - Carbon Monoxide -- metabolism KW - Globins -- metabolism KW - Hemoglobin A -- genetics KW - Protoporphyrins -- chemistry KW - Amino Acid Substitution KW - Hemoglobins -- metabolism KW - Hemoglobins -- genetics KW - Hemoglobins -- chemistry KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72184808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Mutational+effects+at+the+subunit+interfaces+of+human+hemoglobin%3A+evidence+for+a+unique+sensitivity+of+the+T+quaternary+state+to+changes+in+the+hinge+region+of+the+alpha+1+beta+2+interface.&rft.au=Noble%2C+R+W%3BHui%2C+H+L%3BKwiatkowski%2C+L+D%3BPaily%2C+P%3BDeYoung%2C+A%3BWierzba%2C+A%3BColby%2C+J+E%3BBruno%2C+S%3BMozzarelli%2C+A&rft.aulast=Noble&rft.aufirst=R&rft.date=2001-10-16&rft.volume=40&rft.issue=41&rft.spage=12357&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-11-01 N1 - Date created - 2001-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - SHP1 protein-tyrosine phosphatase inhibits gp91PHOX and p67PHOX expression by inhibiting interaction of PU.1, IRF1, interferon consensus sequence-binding protein, and CREB-binding protein with homologous Cis elements in the CYBB and NCF2 genes. AN - 72180450; 11483597 AB - The CYBB and NCF2 genes encode the phagocyte respiratory burst oxidase proteins, gp91PHOX and p67PHOX. Previously, we identified homologous CYBB and NCF2 cis elements that are necessary for lineage-specific transcription during late myeloid differentiation. We determined that these homologous cis elements are activated by PU.1, IRF1, interferon consensus sequence-binding protein (ICSBP), and the CREB-binding protein (CBP). Since expression of PU.1 and ICSBP is lineage-restricted, our investigations identified a mechanism of lineage-specific CYBB and NCF2 transcription. Since PU.1, IRF1, ICSBP, and CBP are expressed in undifferentiated myeloid cells, our investigations did not determine the mechanism of differentiation stage-specific CYBB and NCF2 transcription. In the current investigations, we determine that SHP1 protein-tyrosine phosphatase (SHP1-PTP) inhibits gp91PHOX and p67PHOX expression, in undifferentiated myeloid cell lines, by decreasing interaction of PU.1, IRF1, ICSBP, and CBP with the CYBB and NCF2 genes. We also determine that IRF1 and ICSBP are tyrosine-phosphorylated during interferon gamma differentiation of myeloid cell lines, and we identify IRF1 and ICSBP tyrosine residues that are necessary for CYBB and NCF2 transcription. Therefore, these investigations identify a novel mechanism by which SHP1-PTP antagonizes myeloid differentiation and determine that tyrosine phosphorylation of IRF1 and ICSPB mediates stage-specific transcriptional activation in differentiating myeloid cells. JF - The Journal of biological chemistry AU - Kautz, B AU - Kakar, R AU - David, E AU - Eklund, E A AD - Department of Medicine, Northwestern University Medical School and The Robert H. Lurie Comprehensive Cancer Center, Chicago Lakeside Veterans Administration Hospital, Chicago, Illinois 60611, USA. Y1 - 2001/10/12/ PY - 2001 DA - 2001 Oct 12 SP - 37868 EP - 37878 VL - 276 IS - 41 SN - 0021-9258, 0021-9258 KW - CYBB protein, human KW - 0 KW - DNA Primers KW - Membrane Glycoproteins KW - Phosphoproteins KW - RNA, Messenger KW - Transcription Factors KW - neutrophil cytosol factor 67K KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Gene Expression Regulation, Enzymologic KW - Phosphorylation KW - Humans KW - Transcription, Genetic KW - RNA, Messenger -- genetics KW - Protein Binding KW - U937 Cells KW - Phosphoproteins -- genetics KW - Transcription Factors -- antagonists & inhibitors KW - Transcription Factors -- metabolism KW - Membrane Glycoproteins -- antagonists & inhibitors KW - Phosphoproteins -- antagonists & inhibitors KW - Phosphoproteins -- metabolism KW - Membrane Glycoproteins -- metabolism KW - Membrane Glycoproteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72180450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=SHP1+protein-tyrosine+phosphatase+inhibits+gp91PHOX+and+p67PHOX+expression+by+inhibiting+interaction+of+PU.1%2C+IRF1%2C+interferon+consensus+sequence-binding+protein%2C+and+CREB-binding+protein+with+homologous+Cis+elements+in+the+CYBB+and+NCF2+genes.&rft.au=Kautz%2C+B%3BKakar%2C+R%3BDavid%2C+E%3BEklund%2C+E+A&rft.aulast=Kautz&rft.aufirst=B&rft.date=2001-10-12&rft.volume=276&rft.issue=41&rft.spage=37868&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-10-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - MD-2 Binds to Bacterial Lipopolysaccharide AN - 18104976; 5185458 AB - The exact roles and abilities of the individual components of the lipopolysaccharide (LPS) receptor complex of proteins remain unclear. MD-2 is a molecule found in association with toll-like receptor 4. We produced recombinant human MD-2 to explore its LPS binding ability and role in the LPS receptor complex. MD-2 binds to highly purified rough LPS derived from Salmonella minnesota and Escherichia coli in five different assays; one assay yielded an apparent K sub(D) of 65 nM. MD-2 binding to LPS did not require LPS-binding proteins LBP and CD14; in fact LBP competed with MD-2 for LPS. MD-2 enhanced the biological activity of LPS in toll-like receptor 4-transfected Chinese hamster ovary cells but inhibited LPS activation of U373 astrocytoma cells and of monocytes in human whole blood. These data indicate that MD-2 is a genuine LPS-binding protein and strongly suggest that MD-2 could play a role in regulation of cellular activation by LPS depending on its local availability. JF - Journal of Biological Chemistry AU - Viriyakosol, S AU - Tobias, P S AU - Kitchens, R L AU - Kirkland, T N AD - Veterans Administration San Diego Healthcare System, University of California San Diego, San Diego, California 92161, USA, sviriyak@ucsd.edu Y1 - 2001/10/12/ PY - 2001 DA - 2001 Oct 12 SP - 38044 EP - 38051 VL - 276 IS - 41 SN - 0021-9258, 0021-9258 KW - binding KW - man KW - MD-2 KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - Endotoxins KW - Salmonella minnesota KW - Lipopolysaccharides KW - X 24171:Microbial KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18104976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=MD-2+Binds+to+Bacterial+Lipopolysaccharide&rft.au=Viriyakosol%2C+S%3BTobias%2C+P+S%3BKitchens%2C+R+L%3BKirkland%2C+T+N&rft.aulast=Viriyakosol&rft.aufirst=S&rft.date=2001-10-12&rft.volume=276&rft.issue=41&rft.spage=38044&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Salmonella minnesota; Lipopolysaccharides; Endotoxins ER - TY - JOUR T1 - Comparison of Language Impairment, Functional Communication, and Discourse Measures in African-American Aphasic and Normal Adults AN - 85539589; 200203364 AB - We compared performance on language impairment, functional communication, & discourse measures between 33 African American aphasic patients & 30 African American normal Ss. The aphasic group performed significantly lower than the normal group on the Western Aphasia Battery Aphasia & Cortical Quotients, Token Test, & ASHA Functional Assessment of Communication Skills for Adults. Moreover, the aphasic group performed significantly lower than the normal group in their quality of language on a discourse task that required telling a frightening experience. Significant relationships between performance on the measures were confined to those that index language impairment. Use of a normal ethnic cohort for comparison with African American aphasic performance may control for potential ethnic bias in the measures. In addition, use of a discourse task permits observation of grammatical & stylistic features in African American English that may not be captured or are ignored by traditional language impairment & functional communication measures. 5 Tables, 1 Appendix, 29 References. Adapted from the source document JF - Aphasiology AU - Ulatowska, Hanna K AU - Olness, Gloria S AU - Wertz, Robert T AU - Thompson, Jennifer L AU - Keebler, Molly W AU - Hill, CaSaundra L AU - Auther, Linda L AD - c/o Wertz-Audiology & Speech Pathology, VA Medical Center, South Nashville, TN robert.wertz@med.va.gov Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 1007 EP - 1016 VL - 15 IS - 10-11 SN - 0268-7038, 0268-7038 KW - Language Tests (44250) KW - Language Therapy (44400) KW - Speech Tests (83100) KW - Aphasia (03400) KW - Story Telling (84400) KW - Black Americans (09100) KW - Verbal Tasks (93800) KW - Measures (Instruments) (52300) KW - Speech Production (82780) KW - Black English (09150) KW - article KW - 6812: special education; language therapy KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85539589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Comparison+of+Language+Impairment%2C+Functional+Communication%2C+and+Discourse+Measures+in+African-American+Aphasic+and+Normal+Adults&rft.au=Ulatowska%2C+Hanna+K%3BOlness%2C+Gloria+S%3BWertz%2C+Robert+T%3BThompson%2C+Jennifer+L%3BKeebler%2C+Molly+W%3BHill%2C+CaSaundra+L%3BAuther%2C+Linda+L&rft.aulast=Ulatowska&rft.aufirst=Hanna&rft.date=2001-10-01&rft.volume=15&rft.issue=10-11&rft.spage=1007&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Black Americans (09100); Language Tests (44250); Measures (Instruments) (52300); Speech Production (82780); Verbal Tasks (93800); Speech Tests (83100); Black English (09150); Story Telling (84400); Language Therapy (44400) ER - TY - JOUR T1 - Pott's puffy tumor and epidural abscess arising from dental sepsis: a case report. AN - 85366993; pmid-11801935 AB - To present an unusual case of two uncommon cranial complications of frontal sinusitis: Pott's puffy tumor and epidural abscess arising from frontal sinusitis of dental origin, and also two systemic complications of sinusitis: septicemia and empyema, all occurring in an immunocompetent patient.A 21-year-old man presented with a scalp swelling and epidural abscess. Magnetic resonance imaging and computed tomographic scans revealed unilateral opacification of the frontal sinus and an epidural abscess with a direct connection to the scalp abscess. Further history revealed that his symptoms occurred coincidentally with a tooth extraction 2 months before, and he was hospitalized soon after the tooth extraction for sepsis and a lung abscess.A combined neurosurgical and otolaryngologic approach was required to treat the sinusitis and the associated epidural and scalp abscess.Cultures returned as Streptococcus intermedius from all three sites. The patient was free of disease at the 3-month follow-up.Odontogenic maxillary sinusitis is well documented; however, there is little reported of frontal sinusitis arising from dental disease. The prevalence of sinusitis of dental origin will be reviewed, including the microbiology of this particularly virulent organism that persisted despite earlier treatment with ampicillin. Also, the current thoughts on management of these cases will be discussed with particular reference to local therapy for sinusitis in addition to systemic treatment with antibiotics. JF - The Laryngoscope AU - Chandy, B AU - Todd, J AU - Stucker, F J AU - Nathan, C A AD - Department of Otolaryngology/Head & Neck Surgery, Louisiana State University Health Science Center, the Veterans Administration Shreveport, 71130, USA. Y1 - 2001/10// PY - 2001 DA - Oct 2001 SP - 1732 EP - 1734 VL - 111 IS - 10 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Abscess: diagnosis KW - *Abscess: etiology KW - Abscess: surgery KW - Adult KW - Diagnosis, Differential KW - Empyema, Pleural: diagnosis KW - Empyema, Pleural: etiology KW - Empyema, Pleural: surgery KW - Epidural Abscess: diagnosis KW - *Epidural Abscess: etiology KW - Epidural Abscess: surgery KW - Frontal Sinusitis: diagnosis KW - *Frontal Sinusitis: etiology KW - Frontal Sinusitis: surgery KW - Humans KW - Magnetic Resonance Imaging KW - Male KW - Patient Care Team KW - *Periapical Abscess: surgery KW - Postoperative Complications: diagnosis KW - *Postoperative Complications: etiology KW - Postoperative Complications: surgery KW - Reoperation KW - Scalp: pathology KW - Scalp: surgery KW - Sepsis: diagnosis KW - Sepsis: etiology KW - Sepsis: surgery KW - Streptococcal Infections: diagnosis KW - *Streptococcal Infections: etiology KW - Streptococcal Infections: surgery KW - *Tooth Extraction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85366993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Pott%27s+puffy+tumor+and+epidural+abscess+arising+from+dental+sepsis%3A+a+case+report.&rft.au=Chandy%2C+B%3BTodd%2C+J%3BStucker%2C+F+J%3BNathan%2C+C+A&rft.aulast=Chandy&rft.aufirst=B&rft.date=2001-10-01&rft.volume=111&rft.issue=10&rft.spage=1732&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Kaposi's sarcoma and cytomegaloviral ileocolitis complicating long-standing Crohn's disease in an HIV-negative patient. AN - 85364203; pmid-11693345 AB - A 67-yr-old woman with a 25-yr history of Crohn's disease, maintained on near-continuous corticosteroids (prednisone 10 mg daily) over a 6-yr period, underwent ileocolic resection for obstruction. Pathology revealed Crohn's disease, multiple nodules of Kaposi's sarcoma, and cytomegalic inclusion bodies with confirmation of cytomegalovirus by shell vial immunofluorescence. Testing for HIV serum antibody has been repeatedly negative. Crohn's disease, Kaposi's sarcoma, and cytomegalovirus have been clinically in remission for 5 yr. JF - The American journal of gastroenterology AU - Cohen, R L AU - Tepper, R E AU - Urmacher, C AU - Katz, S AD - Department of Medicine, Veterans Administration Medical Center, New York, New York, USA. Y1 - 2001/10// PY - 2001 DA - Oct 2001 SP - 3028 EP - 3031 VL - 96 IS - 10 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Anti-Inflammatory Agents: therapeutic use KW - *Crohn Disease: complications KW - Crohn Disease: diagnosis KW - *Crohn Disease: drug therapy KW - *Cytomegalovirus Infections: complications KW - Cytomegalovirus Infections: diagnosis KW - Female KW - Glucocorticoids: therapeutic use KW - HIV Seronegativity KW - Humans KW - Prednisone: therapeutic use KW - *Sarcoma, Kaposi: complications KW - Sarcoma, Kaposi: diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85364203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Kaposi%27s+sarcoma+and+cytomegaloviral+ileocolitis+complicating+long-standing+Crohn%27s+disease+in+an+HIV-negative+patient.&rft.au=Cohen%2C+R+L%3BTepper%2C+R+E%3BUrmacher%2C+C%3BKatz%2C+S&rft.aulast=Cohen&rft.aufirst=R&rft.date=2001-10-01&rft.volume=96&rft.issue=10&rft.spage=3028&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Ciprofloxacin microprecipitates and macroprecipitates in the human corneal epithelium. AN - 72254156; 11687375 AB - In 4 corneal transplantation patients treated preoperatively with ciprofloxacin ophthalmic drops, microprecipitates associated with damaged corneal epithelium were noted in 2 patients. Another patient developed a large macroprecipitate in a corneal ulcer. All specimens were examined by electron microscopy and high-pressure liquid chromatography. The crystalline precipitates were pure ciprofloxacin. The macroprecipitate demonstrated a large zone of inhibition on agar plates seeded with a susceptible organism at 24 and 48 hours. It was bioactive and bioavailable in vitro. JF - Journal of cataract and refractive surgery AU - Eiferman, R A AU - Snyder, J P AU - Nordquist, R E AD - Research Service, Veterans Administration Medical Center, Louisville, Kentucky, USA. reiferman@cs.com Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 1701 EP - 1702 VL - 27 IS - 10 SN - 0886-3350, 0886-3350 KW - Anti-Infective Agents KW - 0 KW - Ophthalmic Solutions KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Index Medicus KW - Humans KW - Chemical Precipitation KW - Aged KW - Female KW - Chromatography, High Pressure Liquid KW - Microscopy, Electron, Scanning KW - Corneal Transplantation KW - Anti-Infective Agents -- adverse effects KW - Epithelium, Corneal -- drug effects KW - Corneal Ulcer -- chemically induced KW - Corneal Ulcer -- pathology KW - Ciprofloxacin -- adverse effects KW - Antibiotic Prophylaxis KW - Epithelium, Corneal -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72254156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cataract+and+refractive+surgery&rft.atitle=Ciprofloxacin+microprecipitates+and+macroprecipitates+in+the+human+corneal+epithelium.&rft.au=Eiferman%2C+R+A%3BSnyder%2C+J+P%3BNordquist%2C+R+E&rft.aulast=Eiferman&rft.aufirst=R&rft.date=2001-10-01&rft.volume=27&rft.issue=10&rft.spage=1701&rft.isbn=&rft.btitle=&rft.title=Journal+of+cataract+and+refractive+surgery&rft.issn=08863350&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-07 N1 - Date created - 2001-11-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Cataract Refract Surg. 2002 Jun;28(6):909; author reply 909 [12036608] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of the reactive oxygen species hydrogen peroxide and hypochlorite on endothelial nitric oxide production. AN - 72216851; 11641302 AB - Reactive oxygen species (ROS) hydrogen peroxide (H(2)O(2)) and hypochlorite (HOCl) participate in the pathogenesis of ischemia/reperfusion injury, inflammation, and atherosclerosis. Both NO and ROS are important modulators of vascular tone and architecture and of adhesive interactions between leukocytes, platelets, and vascular endothelium. We studied the effect of H(2)O(2) and HOCl on receptor-dependent (bradykinin [10(-6) mol/L] and ADP [10(-4) mol/L]) and receptor-independent mechanisms (calcium ionophore A23187 [10(-6) mol/L]) of NO production by porcine aortic endothelial cells (ECs). Changes in the level of EC cGMP (the second messenger of NO) were used as a surrogate of NO production. EC cGMP increased 300% in response to bradykinin and A23187 and 200% in response to ADP. Exposure of ECs to H(2)O(2) (50 micromol/L) for 30 minutes significantly impaired cGMP levels in response to ADP, bradykinin, and the receptor-independent NO agonist A23187. In contrast, preincubation with HOCl (50 micromol/L) impaired cGMP production only in response to ADP and bradykinin but not A23187. These concentrations of H(2)O(2) and HOCl did not result in increased EC lethality as assessed by lactate dehydrogenase release. Neither H(2)O(2) nor HOCl affected EC cGMP production in response to NO donor sodium nitroprusside, which suggests that guanylate cyclase is resistant to these oxidants. We also demonstrated that neither H(2)O(2) nor HOCl affects endothelial NO synthase (eNOS) catalytic activity as measured by conversion of L-arginine to L-citrulline in EC homogenates supplemented with eNOS cofactors. The present studies show that H(2)O(2) impairs NO production in response to both receptor-dependent and receptor-independent agonists and that these effects are due, at least in part, to inactivation of eNOS cofactors, whereas HOCl inhibits NO production by interfering with receptor-operated mechanisms at the level of the cell membrane. Concentrations of H(2)O(2) and HOCl used in the present studies have been shown to be generated in vivo during inflammation and ischemia/reperfusion. Therefore, we infer that these effects of H(2)O(2) and HOCl on EC NO production may contribute to disregulated vascular tone and altered leukocyte-EC interactions that occur in vascular injury as a result of those causes in which ROS generation is involved. JF - Hypertension (Dallas, Tex. : 1979) AU - Jaimes, E A AU - Sweeney, C AU - Raij, L AD - Nephrology and Hypertension Section, Veterans Administration Medical Center, Minneapolis, Minnesota, USA. Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 877 EP - 883 VL - 38 IS - 4 KW - Enzyme Inhibitors KW - 0 KW - Oxidants KW - Nitroprusside KW - 169D1260KM KW - omega-N-Methylarginine KW - 27JT06E6GR KW - Nitric Oxide KW - 31C4KY9ESH KW - Calcimycin KW - 37H9VM9WZL KW - Adenosine Diphosphate KW - 61D2G4IYVH KW - Hypochlorous Acid KW - 712K4CDC10 KW - Arginine KW - 94ZLA3W45F KW - Hydrogen Peroxide KW - BBX060AN9V KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Nitric Oxide Synthase Type III KW - Cyclic GMP KW - H2D2X058MU KW - Bradykinin KW - S8TIM42R2W KW - Index Medicus KW - Swine KW - Animals KW - Adenosine Diphosphate -- pharmacology KW - Calcimycin -- pharmacology KW - Arginine -- pharmacology KW - Cyclic GMP -- metabolism KW - Cells, Cultured KW - Nitric Oxide Synthase -- antagonists & inhibitors KW - Enzyme Inhibitors -- pharmacology KW - omega-N-Methylarginine -- pharmacology KW - Bradykinin -- pharmacology KW - Nitroprusside -- pharmacology KW - Nitric Oxide Synthase -- metabolism KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Oxidants -- pharmacology KW - Endothelium, Vascular -- cytology KW - Hypochlorous Acid -- pharmacology KW - Hydrogen Peroxide -- pharmacology KW - Nitric Oxide -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72216851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Effects+of+the+reactive+oxygen+species+hydrogen+peroxide+and+hypochlorite+on+endothelial+nitric+oxide+production.&rft.au=Jaimes%2C+E+A%3BSweeney%2C+C%3BRaij%2C+L&rft.aulast=Jaimes&rft.aufirst=E&rft.date=2001-10-01&rft.volume=38&rft.issue=4&rft.spage=877&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=1524-4563&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-11-01 N1 - Date created - 2001-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Parallel increases in lipid and protein oxidative markers in several mouse brain regions after methamphetamine treatment. AN - 72191203; 11595767 AB - The neurotoxic actions of methamphetamine (METH) may be mediated in part by reactive oxygen species (ROS). Methamphetamine administration leads to increases in ROS formation and lipid peroxidation in rodent brain; however, the extent to which proteins may be modified or whether affected brain regions exhibit similar elevations of lipid and protein oxidative markers have not been investigated. In this study we measured concentrations of TBARs, protein carbonyls and monoamines in various mouse brain regions at 4 h and 24 h after the last of four injections of METH (10 mg/kg/injection q 2 h). Substantial increases in TBARs and protein carbonyls were observed in the striatum and hippocampus but not the frontal cortex nor the cerebellum of METH-treated mice. Furthermore, lipid and protein oxidative markers were highly correlated within each brain region. In the hippocampus and striatum elevations in oxidative markers were significantly greater at 24 h than at 4 h. Monoamine levels were maximally reduced within 4 h (striatal dopamine [DA] by 95% and serotonin [5-HT] in striatum, cortex and hippocampus by 60-90%). These decrements persisted for 7 days after METH, indicating effects reflective of nerve terminal damage. Interestingly, NE was only transiently depleted in the brain regions investigated (hippocampus and cortex), suggesting a pharmacological and non-toxic action of METH on the noradrenergic nerve terminals. This study provides the first evidence for concurrent formation of lipid and protein markers of oxidative stress in several brain regions of mice that are severely affected by large neurotoxic doses of METH. Moreover, the differential time course for monoamine depletion and the elevations in oxidative markers indicate that the source of oxidative stress is not derived directly from DA or 5HT oxidation. JF - Journal of neurochemistry AU - Gluck, M R AU - Moy, L Y AU - Jayatilleke, E AU - Hogan, K A AU - Manzino, L AU - Sonsalla, P K AD - Department of Neurology, Bronx Veterans Medical CenterBronx, New York, USA. gluck.martin@bronx.va.gov Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 152 EP - 160 VL - 79 IS - 1 SN - 0022-3042, 0022-3042 KW - Biogenic Monoamines KW - 0 KW - Biomarkers KW - Nerve Tissue Proteins KW - Reactive Oxygen Species KW - Thiobarbituric Acid Reactive Substances KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - Serotonin KW - 333DO1RDJY KW - Methamphetamine KW - 44RAL3456C KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Cerebral Cortex -- drug effects KW - Cerebral Cortex -- metabolism KW - Hydroxyindoleacetic Acid -- metabolism KW - Corpus Striatum -- metabolism KW - Hippocampus -- metabolism KW - Thiobarbituric Acid Reactive Substances -- analysis KW - Dopamine -- metabolism KW - Mice KW - Biogenic Monoamines -- metabolism KW - Cerebellum -- metabolism KW - Hippocampus -- drug effects KW - Oxidation-Reduction KW - 3,4-Dihydroxyphenylacetic Acid -- metabolism KW - Cerebellum -- drug effects KW - Oxidative Stress KW - Corpus Striatum -- drug effects KW - Serotonin -- metabolism KW - Male KW - Brain -- drug effects KW - Biomarkers -- analysis KW - Methamphetamine -- pharmacology KW - Nerve Tissue Proteins -- metabolism KW - Brain -- metabolism KW - Lipid Peroxidation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72191203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Parallel+increases+in+lipid+and+protein+oxidative+markers+in+several+mouse+brain+regions+after+methamphetamine+treatment.&rft.au=Gluck%2C+M+R%3BMoy%2C+L+Y%3BJayatilleke%2C+E%3BHogan%2C+K+A%3BManzino%2C+L%3BSonsalla%2C+P+K&rft.aulast=Gluck&rft.aufirst=M&rft.date=2001-10-01&rft.volume=79&rft.issue=1&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of base in the treatment of severe acidemic states. AN - 71208791; 11576874 AB - Severe acidemia (blood pH < 7.1 to 7.2) suppresses myocardial contractility, predisposes to cardiac arrhythmias, causes venoconstriction, and can decrease total peripheral vascular resistance and blood pressure, reduce hepatic blood flow, and impair oxygen delivery. These alterations in organ function can contribute to increased morbidity and mortality. Although it seemed logical to administer sodium bicarbonate to attenuate acidemia and therefore lessen the impact on cardiac function, the routine use of bicarbonate in the treatment of the most common causes of severe acidemia, diabetic ketoacidosis, lactic acidosis, and cardiac arrest, has been an issue of great controversy. Studies of animals and patients with these disorders have reported conflicting data on the benefits of bicarbonate, showing both beneficial and detrimental effects. Alternative alkalinizing agents, tris-hydroxymethyl aminomethane and Carbicarb, have shown some promise in studies of animals and humans, and reevaluation of these buffers in the treatment of severe acidemic states seems warranted. The potential value of base therapy in the treatment of severe acidemia remains an important issue, and further studies are required to determine which patients should be administered base therapy and what base should be used. JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Kraut, J A AU - Kurtz, I AD - Division of Nephrology, Veterans Administration Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA. jkraut@ucla.edu Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 703 EP - 727 VL - 38 IS - 4 KW - Bicarbonates KW - 0 KW - Buffers KW - Carbonates KW - Drug Combinations KW - sodium bicarbonate, sodium carbonate drug combination KW - Tromethamine KW - 023C2WHX2V KW - Sodium Bicarbonate KW - 8MDF5V39QO KW - Potassium KW - RWP5GA015D KW - Oxygen KW - S88TT14065 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Acidosis, Lactic -- drug therapy KW - Arrhythmias, Cardiac -- etiology KW - Vascular Resistance KW - Acidosis, Lactic -- etiology KW - Diabetic Ketoacidosis -- drug therapy KW - Oxygen -- metabolism KW - Humans KW - Carbonates -- therapeutic use KW - Cardiac Output -- drug effects KW - Potassium -- metabolism KW - Heart Arrest -- drug therapy KW - Calcium -- metabolism KW - Myocardial Contraction KW - Acidosis, Lactic -- complications KW - Tromethamine -- therapeutic use KW - Heart Arrest -- complications KW - Water-Electrolyte Balance -- physiology KW - Sodium Bicarbonate -- adverse effects KW - Acidosis -- therapy KW - Acidosis -- blood KW - Sodium Bicarbonate -- therapeutic use KW - Bicarbonates -- metabolism KW - Acidosis -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71208791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Use+of+base+in+the+treatment+of+severe+acidemic+states.&rft.au=Kraut%2C+J+A%3BKurtz%2C+I&rft.aulast=Kraut&rft.aufirst=J&rft.date=2001-10-01&rft.volume=38&rft.issue=4&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=1523-6838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-18 N1 - Date created - 2001-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Kidney Dis. 2002 May;39(5):1125-6; discussion 1126 [11979362] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic fatigue and sexual dysfunction in female Gulf War veterans. AN - 71165831; 11554210 AB - Chronic fatigue (CF) is one of the most common conditions reported by Gulf War veterans. This study evaluated female sexual dysfunction (FSD) in veterans with or without complaints of CF. Subjects were screened for medical and psychiatric causes of CF. They included 22 healthy subjects and 26 with fatiguing symptoms. FSD was reported by 10% of controls and by 60% of the fatigued (p < .002) while 19% versus 81% (p < .001) noted decreased libido. FSD was more prevalent in fatigued veterans than in the controls. This relationship was not mediated by an Axis I diagnosis. This appears to be the first report of sexual dysfunction in CF. JF - Journal of sex & marital therapy AU - Gilhooly, P E AU - Ottenweller, J E AU - Lange, G AU - Tiersky, L AU - Natelson, B H AD - Veterans Administration, New Jersey Health Care System, 385 Tremont Avenue, East Orange, NJ 07018, USA. PEGMD6@aol.com PY - 2001 SP - 483 EP - 487 VL - 27 IS - 5 SN - 0092-623X, 0092-623X KW - Index Medicus KW - Severity of Illness Index KW - Vagina -- physiopathology KW - Sexual Dysfunctions, Psychological -- epidemiology KW - Sexual Dysfunctions, Psychological -- diagnosis KW - Humans KW - Adult KW - Sexual Dysfunctions, Psychological -- physiopathology KW - Female KW - Prevalence KW - Fatigue Syndrome, Chronic -- diagnosis KW - Veterans -- psychology KW - Persian Gulf Syndrome -- psychology KW - Fatigue Syndrome, Chronic -- psychology KW - Fatigue Syndrome, Chronic -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71165831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+sex+%26+marital+therapy&rft.atitle=Chronic+fatigue+and+sexual+dysfunction+in+female+Gulf+War+veterans.&rft.au=Gilhooly%2C+P+E%3BOttenweller%2C+J+E%3BLange%2C+G%3BTiersky%2C+L%3BNatelson%2C+B+H&rft.aulast=Gilhooly&rft.aufirst=P&rft.date=2001-10-01&rft.volume=27&rft.issue=5&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Journal+of+sex+%26+marital+therapy&rft.issn=0092623X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-07 N1 - Date created - 2001-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - "Transcend": Initial Outcomes from a Posttraumatic Stress Disorder/Substance Abuse Treatment Program AN - 61507578; 200203304 AB - This paper describes the development of a comprehensive treatment program for combat veterans diagnosed with posttraumatic stress disorder (PTSD) & substance abuse (SA). Outcome data are presented on 46 male patients who completed treatment between 1996 & 1998. The treatment approach, defined by a detailed manual, integrates elements of cognitive-behavioral skills training, constructivist theory approaches, SA relapse prevention strategies, & peer social support into a group-focused program. The Clinician-Administered PTSD Scale (CAPS) & the Addiction Severity Index (ASI) were used to assess treatment effectiveness at discharge & 6- & 12-month follow-up. Significant symptom changes revealed on CAPS & ASI scores at discharge & follow-up are analyzed. Discussion focuses on hypotheses regarding treatment effectiveness, study limitations, & suggestions for further research. 2 Tables, 68 References. Adapted from the source document. JF - Journal of Traumatic Stress AU - Donovan, Beverly AU - Padin-Rivera, Edgardo AU - Kowaliw, Sean AD - Louis Stokes Cleveland Veterans Affairs Medical Center, Brecksville, OH beverly.donovan@med.va.gov Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 757 EP - 772 VL - 14 IS - 4 SN - 0894-9867, 0894-9867 KW - Veterans KW - Treatment Outcomes KW - Substance Abuse KW - Treatment Programs KW - Males KW - Cleveland, Ohio KW - Posttraumatic Stress Disorder KW - article KW - 6129: addiction KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61507578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Traumatic+Stress&rft.atitle=%22Transcend%22%3A+Initial+Outcomes+from+a+Posttraumatic+Stress+Disorder%2FSubstance+Abuse+Treatment+Program&rft.au=Donovan%2C+Beverly%3BPadin-Rivera%2C+Edgardo%3BKowaliw%2C+Sean&rft.aulast=Donovan&rft.aufirst=Beverly&rft.date=2001-10-01&rft.volume=14&rft.issue=4&rft.spage=757&rft.isbn=&rft.btitle=&rft.title=Journal+of+Traumatic+Stress&rft.issn=08949867&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JTSTEB N1 - SubjectsTermNotLitGenreText - Treatment Programs; Veterans; Posttraumatic Stress Disorder; Substance Abuse; Treatment Outcomes; Males; Cleveland, Ohio ER - TY - JOUR T1 - Characteristics of patients with gaze-evoked tinnitus. AN - 85357796; pmid-11568674 AB - The authors describe symptoms and population characteristics in subjects who can modulate the loudness and/or pitch of their tinnitus by eye movements.Data were obtained by questionnaire.The study was conducted at a university center and a tertiary care center.Respondents had the self-reported ability to modulate their tinnitus with eye movements.Ninety-one subjects reported having gaze-evoked tinnitus after posterior fossa surgery involving the eighth nerve. Eighty-seven of them underwent removal of a vestibular schwannoma (acoustic neuroma), two had bilateral eighth nerve tumors (one underwent bilateral tumor removal; the other unilateral tumor removal), one underwent removal of a cholesteatoma, and one underwent removal of a glomus jugulare tumor. Seventeen subjects who had never had posterior fossa surgery reported gaze-evoked tinnitus. Of those with vestibular schwannomas, tumor size ranged from small (4 cm). The gender distribution was 48.3% male and 51.7% female. In 77% of patients, the gaze-evoked tinnitus was localized to the surgical ear or side of head; 21.8% had bilateral tinnitus that was louder in the surgical ear or side of head. In 86 of 87 subjects, loudness of tinnitus changed with eye movement. Eye movement away from the central (eyes centered) position increased the loudness of tinnitus in all 86 subjects who responded to this question. Seventy-three of 85 (85.9%) patients indicated that pitch changed with eye movement, with pitch increasing in 64/72 (88.9%) of them. Eighty-three of 87 (95.4%) patients reported total loss of hearing in the surgical ear. Seventy of 83 (84.3%) patients reported facial nerve problems immediately after surgery, 52 of 87 (60%) reported persistent facial weakness, and 16 of 87 (18.4%) patients reported persistent double vision. In those 17 subjects with gaze-evoked tinnitus and no posterior fossa surgery, the majority of respondents (14/17, 82.4%) were male.Gaze-evoked tinnitus after cerebellar pontine angle surgery is more common than was previously believed. In addition, posterior fossa surgery is not a prerequisite for the development of gaze-evoked tinnitus. It is likely that gaze-evoked tinnitus is a manifestation of functional reorganization. Gaze-evoked tinnitus could result from an unmasking of brain regions that respond to multiple stimulus/response modalities, and/or from anomalous cross-modality interactions, perhaps caused by collateral sprouting. JF - Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology AU - Coad, M L AU - Lockwood, A AU - Salvi, R AU - Burkard, R AD - Veterans Administration Western New York Healthcare System, and Department of Neurology, University at Buffalo, Buffalo, New York 14214, USA. Y1 - 2001/09// PY - 2001 DA - Sep 2001 SP - 650 EP - 654 VL - 22 IS - 5 SN - 1531-7129, 1531-7129 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Cerebellopontine Angle: blood supply KW - Cerebellopontine Angle: surgery KW - Cochlear Nerve: surgery KW - Female KW - *Fixation, Ocular: physiology KW - Humans KW - Male KW - Middle Aged KW - Postoperative Period KW - Questionnaires KW - *Saccades: physiology KW - Severity of Illness Index KW - Tinnitus: diagnosis KW - *Tinnitus: etiology KW - Tomography, Emission-Computed UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85357796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otology+%26+neurotology+%3A+official+publication+of+the+American+Otological+Society%2C+American+Neurotology+Society+%5Band%5D+European+Academy+of+Otology+and+Neurotology&rft.atitle=Characteristics+of+patients+with+gaze-evoked+tinnitus.&rft.au=Coad%2C+M+L%3BLockwood%2C+A%3BSalvi%2C+R%3BBurkard%2C+R&rft.aulast=Coad&rft.aufirst=M&rft.date=2001-09-01&rft.volume=22&rft.issue=5&rft.spage=650&rft.isbn=&rft.btitle=&rft.title=Otology+%26+neurotology+%3A+official+publication+of+the+American+Otological+Society%2C+American+Neurotology+Society+%5Band%5D+European+Academy+of+Otology+and+Neurotology&rft.issn=15317129&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Cisplatin-induced vomiting depends on circadian timing. AN - 72356487; 11763992 AB - We examined whether the clock time of cisplatin plus antiemetic and diuretic administration affects the amount of cisplatin-associated emesis and severity of renal toxicity. We treated 22 patients with urogenital cancer with two courses of chemotherapy containing 70 mg/m2 of cisplatin. Cisplatin together with furosemide was administered in the morning (05:00) or evening (17:00) during two courses 1 month apart in a crossover fashion. Ondansetron was given either before or after cisplatin to control nausea and vomiting. The number of vomiting episodes, serum creatinine, serum urea nitrogen (BUN), creatinine clearance, and urinary beta-N-acetyl glucosamidase (NAG) concentration were evaluated before and after each treatment course. Regardless of the timing of ondansetron, morning compared to evening cisplatin was always associated with greater vomiting in the first treatment course. However, prophylactic administration of ondansetron markedly diminished the impact of the clock time of cisplatin administration. Serum creatinine transiently decreased rather than increased 14 days after cisplatin and furosemide administration, while NAG excretion increased 3 days after cisplatin and furosemide administration. In the first course, serum creatinine levels were similar regardless of the clock time of cisplatin and furosemide administration. However, in the second course, serum creatinine rose in patients given evening cisplatin and furosemide, while it remained unchanged in those given morning cisplatin and furosemide. Moreover, the first course morning cisplatin and furosemide treatment was associated with less change in NAG excretion (less kidney toxicity) than the first course of evening cisplatin and furosemide treatment. The second course evening cisplatin and furosemide treatment was associated with an increase in NAG excretion compared to the first course of treatment, while morning cisplatin and furosemide treatment in the second course showed less change in NAG excretion compared to the first course. The clock time of cisplatin administration had an impact on the frequency of emesis. Prophylactic ondansetron, however, diminished the time-of-day dependency of cisplatin-induced vomiting. Administration of cisplatin and furosemide in the morning rather than evening appears to cause less renal damage, and this damage may be further reduced with aggressive hydration and routine administration of furosemide. JF - Chronobiology international AU - Kobayashi, M AU - To, H AU - Tokue, A AU - Fujimura, A AU - Kobayashi, E AD - Department of Urology, Center of Molecular Medicine, Jichi Medical School, Tochigi, Japan. minoru.kobayashi@med.va.gov Y1 - 2001/09// PY - 2001 DA - September 2001 SP - 851 EP - 863 VL - 18 IS - 5 SN - 0742-0528, 0742-0528 KW - Antiemetics KW - 0 KW - Antineoplastic Agents KW - Diuretics KW - Ondansetron KW - 4AF302ESOS KW - Furosemide KW - 7LXU5N7ZO5 KW - Creatinine KW - AYI8EX34EU KW - Acetylglucosaminidase KW - EC 3.2.1.52 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Urogenital Neoplasms -- drug therapy KW - Ondansetron -- administration & dosage KW - Humans KW - Acetylglucosaminidase -- urine KW - Kidney -- drug effects KW - Aged KW - Blood Urea Nitrogen KW - Creatinine -- blood KW - Urogenital Neoplasms -- physiopathology KW - Antiemetics -- administration & dosage KW - Adult KW - Kidney -- injuries KW - Cross-Over Studies KW - Furosemide -- administration & dosage KW - Middle Aged KW - Diuretics -- administration & dosage KW - Male KW - Kidney -- physiopathology KW - Antineoplastic Agents -- administration & dosage KW - Vomiting -- chemically induced KW - Cisplatin -- adverse effects KW - Chronotherapy KW - Cisplatin -- administration & dosage KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72356487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chronobiology+international&rft.atitle=Cisplatin-induced+vomiting+depends+on+circadian+timing.&rft.au=Kobayashi%2C+M%3BTo%2C+H%3BTokue%2C+A%3BFujimura%2C+A%3BKobayashi%2C+E&rft.aulast=Kobayashi&rft.aufirst=M&rft.date=2001-09-01&rft.volume=18&rft.issue=5&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=Chronobiology+international&rft.issn=07420528&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-10 N1 - Date created - 2001-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The cost-effectiveness of buprenorphine maintenance therapy for opiate addiction in the United States. AN - 72217134; 11672491 AB - To determine the cost-effectiveness of buprenorphine maintenance therapy for opiate addiction in the United States, particularly its effect on the HIV epidemic. We developed a dynamic model to capture the effects of adding buprenorphine maintenance to the current opiate dependence treatment system. We evaluated incremental costs, including all health-care costs, and incremental effectiveness, measured as quality-adjusted life years (QALYs) of survival. We considered communities with HIV prevalence among injection drug users of 5% and 40%. Because no price has been set in the United States for a dose of buprenorphine, we considered three prices per dose: $5, $15, and $30. If buprenorphine increases the number of individuals in maintenance treatment by 10%, but does not affect the number of individuals receiving methadone maintenance, the cost-effectiveness ratios for buprenorphine maintenance therapy are less than $45 000 per QALY gained for all prices, in both the low-prevalence and high-prevalence communities. If the same number of individuals enter buprenorphine maintenance (10% of the number currently in methadone), but half are injection drug users newly entering maintenance and half are individuals who switched from methadone to buprenorphine, the cost-effectiveness ratios in both communities are less than $45 000 per QALY gained for the $5 and $15 prices, and greater than $65 000 per QALY gained for the $30 price. At a price of $5 or less per dose, buprenorphine maintenance is cost-effective under all scenarios we considered. At $15 per dose, it is cost-effective if its adoption does not lead to a net decline in methadone use, or if a medium to high value is assigned to the years of life lived by injection drug users and those in maintenance therapy. At $30 per dose, buprenorphine will be cost-effective only under the most optimistic modeling assumptions. JF - Addiction (Abingdon, England) AU - Barnett, P G AU - Zaric, G S AU - Brandeau, M L AD - Health Economics Resource Center, Veterans Affairs Palo Alto Health Care System, Menlo Park, CA, USA and the Department of Health Research and Policy, Stanford University, Stanford, CA, USA. paul.barnett@med.va.gov Y1 - 2001/09// PY - 2001 DA - September 2001 SP - 1267 EP - 1278 VL - 96 IS - 9 SN - 0965-2140, 0965-2140 KW - Narcotic Antagonists KW - 0 KW - Buprenorphine KW - 40D3SCR4GZ KW - Index Medicus KW - United States KW - Quality-Adjusted Life Years KW - Humans KW - Cost-Benefit Analysis KW - Buprenorphine -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Buprenorphine -- economics KW - Opioid-Related Disorders -- rehabilitation KW - Opioid-Related Disorders -- economics KW - Narcotic Antagonists -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72217134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=The+cost-effectiveness+of+buprenorphine+maintenance+therapy+for+opiate+addiction+in+the+United+States.&rft.au=Barnett%2C+P+G%3BZaric%2C+G+S%3BBrandeau%2C+M+L&rft.aulast=Barnett&rft.aufirst=P&rft.date=2001-09-01&rft.volume=96&rft.issue=9&rft.spage=1267&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-10-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Addiction. 2001 Oct;96(10):1515-7 [11599513] Addiction. 2001 Oct;96(10):1515 [11599512] Addiction. 2001 Oct;96(10):1517-8 [11599514] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Divalproex sodium in alcohol withdrawal: a randomized double-blind placebo-controlled clinical trial. AN - 71210364; 11584152 AB - Divalproex sodium, an anticonvulsant and antikindling agent and gamma-aminobutyric acid enhancer, has been proposed as an alternative to benzodiazepines for treating alcohol withdrawal. This study reports on a randomized, double-blind, placebo-controlled trial of divalproex sodium in acute alcohol withdrawal. Thirty-six hospitalized patients experiencing moderate alcohol withdrawal as measured by a score of at least 10 on the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar) were randomized to receive either divalproex sodium 500 mg three times per day for 7 days or matched placebo in a double-blind manner. All subjects received a baseline dose of oxazepam and had additional oxazepam available as a rescue medication in accordance with a standard, symptom-triggered detoxification protocol. Mean total milligrams of oxazepam received, progression of withdrawal symptoms, psychological distress as measured by the Symptom Checklist-90, side effects, and adverse outcomes were compared between groups. Use of divalproex sodium resulted in less use of oxazepam (p or=10) after 12 hr. The progression in severity of withdrawal symptoms (increase in CIWA-Ar above baseline) was also significantly greater in the placebo group (p < 0.05). This placebo-controlled pilot study suggests that divalproex sodium significantly affects the course of acute alcohol withdrawal and reduces the need for treatment with a benzodiazepine. A more aggressive loading dose strategy may demonstrate a more robust or earlier response. JF - Alcoholism, clinical and experimental research AU - Reoux, J P AU - Saxon, A J AU - Malte, C A AU - Baer, J S AU - Sloan, K L AD - Veterans Affairs Puget Sound Health Care System and Department of Psychiatry, University of Washington School of Medicine, Seattle, Washington 98108, USA. joe.reoux@med.va.gov Y1 - 2001/09// PY - 2001 DA - September 2001 SP - 1324 EP - 1329 VL - 25 IS - 9 SN - 0145-6008, 0145-6008 KW - Anticonvulsants KW - 0 KW - GABA Modulators KW - Placebos KW - Ethanol KW - 3K9958V90M KW - Valproic Acid KW - 614OI1Z5WI KW - Oxazepam KW - 6GOW6DWN2A KW - Index Medicus KW - GABA Modulators -- therapeutic use KW - Oxazepam -- therapeutic use KW - Depression KW - Anxiety KW - Double-Blind Method KW - Alcoholism -- therapy KW - Humans KW - Aged KW - Oxazepam -- administration & dosage KW - Hostility KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Adolescent KW - GABA Modulators -- administration & dosage KW - Male KW - Female KW - Ethanol -- adverse effects KW - Anticonvulsants -- adverse effects KW - Substance Withdrawal Syndrome -- drug therapy KW - Valproic Acid -- adverse effects KW - Anticonvulsants -- administration & dosage KW - Valproic Acid -- therapeutic use KW - Anticonvulsants -- therapeutic use KW - Valproic Acid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71210364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Divalproex+sodium+in+alcohol+withdrawal%3A+a+randomized+double-blind+placebo-controlled+clinical+trial.&rft.au=Reoux%2C+J+P%3BSaxon%2C+A+J%3BMalte%2C+C+A%3BBaer%2C+J+S%3BSloan%2C+K+L&rft.aulast=Reoux&rft.aufirst=J&rft.date=2001-09-01&rft.volume=25&rft.issue=9&rft.spage=1324&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - GDNF improves cerebellar Purkinje neuron function in aged F344 rats. AN - 71114435; 11514987 AB - Aging is associated with a decline in the function of beta-adrenergic receptor responses in the cerebellum. This decline in noradrenergic receptor sensitivity may underlie some of the accompanying age-related declines in motoric learning behaviors. Glial cell line-derived neurotrophic factor (GDNF) has been reported to prevent the degeneration of noradrenergic neurons following neurotoxic lesions. Thus, it was of interest to examine if GDNF would have a beneficial effect on age-related declines in noradrenergic function. Eighteen-month-old F344 rats were injected with 500 microg GDNF in 20 microl into the cisterna magna. Three weeks following GDNF or vehicle treatment, rats were tested on a motor coordination task and then examined electrophysiologically under urethane anesthesia. GDNF did not produce an improvement in performance on an inclined balance beam or an accelerating rotorod. In young (3-month-old) F344 rats isoproterenol (ISO) will increase GABAergic inhibitions in the majority of cells examined; however, in aged rats only about 30% of neurons demonstrate this phenotype. In the aged rats treated with GDNF, ISO was able to increase GABAergic inhibitions in greater than 75% of the neurons tested, thus returning the neurons to a young phenotype. We examined the brains for expression of bcl-2, which has been shown to be increased in the aged cerebellum. GDNF was able to down-regulate this neuronal signal. Thus, intra-cisterna magna delivery of GDNF to aged rats improved beta-adrenergic receptor function and reduced stress related signaling of bcl-2 in the aged F344 rats to a level similar to that observed in young rats. Copyright 2001 Wiley-Liss, Inc. JF - Microscopy research and technique AU - Bickford, P C AU - Bowenkamp, K AU - Taglialatela, G AU - Hoertig, G AU - Granholm, A C AD - Veterans Administration Medical Center, Tampa, Florida 33612, USA. pbickfor@hsc.usf.edu Y1 - 2001/09/01/ PY - 2001 DA - 2001 Sep 01 SP - 309 EP - 316 VL - 54 IS - 5 SN - 1059-910X, 1059-910X KW - Gdnf protein, rat KW - 0 KW - Glial Cell Line-Derived Neurotrophic Factor KW - Nerve Growth Factors KW - Nerve Tissue Proteins KW - Neuroprotective Agents KW - Proto-Oncogene Proteins c-bcl-2 KW - Index Medicus KW - Rats KW - Behavior, Animal -- drug effects KW - Animals KW - Rats, Inbred F344 KW - Proto-Oncogene Proteins c-bcl-2 -- analysis KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Immunohistochemistry KW - Injections, Intraventricular KW - Cerebellum -- cytology KW - Purkinje Cells -- drug effects KW - Neuroprotective Agents -- administration & dosage KW - Cerebellum -- drug effects KW - Aging -- drug effects KW - Purkinje Cells -- metabolism KW - Nerve Tissue Proteins -- administration & dosage KW - Nerve Tissue Proteins -- pharmacology KW - Cerebellum -- physiology KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71114435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microscopy+research+and+technique&rft.atitle=GDNF+improves+cerebellar+Purkinje+neuron+function+in+aged+F344+rats.&rft.au=Bickford%2C+P+C%3BBowenkamp%2C+K%3BTaglialatela%2C+G%3BHoertig%2C+G%3BGranholm%2C+A+C&rft.aulast=Bickford&rft.aufirst=P&rft.date=2001-09-01&rft.volume=54&rft.issue=5&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Microscopy+research+and+technique&rft.issn=1059910X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-11-01 N1 - Date created - 2001-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Invasion of Human Fallopian Tube Epithelium by Escherichia coli Expressing Combinations of a Gonococcal Porin, Opacity-Associated Protein, and Chimeric Lipo-oligosaccharide AN - 18091706; 5185134 AB - The transepithelial migration of Escherichia coli that expressed all possible combinations of a plasmid-encoded gonococcal porin (Por), opacity-associated protein (Opa), and 3F11 lipo-oligosaccharide (LOS) epitope was investigated. Surface expression of Por mediated selective changes in E. coli antibiotic susceptibility, and coexpression of Opa and the 3F11 LOS epitope mediated bacterial clumping (P < .01). In the human fallopian tube organ-culture model, Opa-producing variants attached up to 44-fold better than control bacteria (P < .01), and Por-producing variants exceeded submucosal invasion of control bacteria by 500-fold (P < .01). Opa and Por each facilitated intracellular invasion 20-40-fold (P < .01). In dual expresser variants, the 3F11 LOS epitope markedly reduced attachment and invasion mediated by Opa or Por. The LOS inhibitory effect was curbed when all 3 factors were expressed, which suggests an additional interaction of the 3 factors at the bacterial surface. Por, Opa, and LOS play important roles in Neisseria gonorrhoeae trafficking across human fallopian tube epithelium. JF - Journal of Infectious Diseases AU - Gorby, G L AU - Ehrhardt, A F AU - Apicella, MA AU - Elkins, C AD - Department of Medicine, Omaha Veterans Administration Medical Center, Creighton University School of Medicine, Omaha, Nebraska, USA Y1 - 2001/08/15/ PY - 2001 DA - 2001 Aug 15 SP - 460 EP - 472 VL - 184 IS - 4 SN - 0022-1899, 0022-1899 KW - man KW - invasion KW - lipooligosaccharides KW - opacity-associated protein KW - Microbiology Abstracts B: Bacteriology KW - Porins KW - Escherichia coli KW - Epithelium KW - Reproductive organs KW - Fallopian tube KW - Neisseria gonorrhoeae KW - J 02847:Genitourinary tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18091706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Invasion+of+Human+Fallopian+Tube+Epithelium+by+Escherichia+coli+Expressing+Combinations+of+a+Gonococcal+Porin%2C+Opacity-Associated+Protein%2C+and+Chimeric+Lipo-oligosaccharide&rft.au=Gorby%2C+G+L%3BEhrhardt%2C+A+F%3BApicella%2C+MA%3BElkins%2C+C&rft.aulast=Gorby&rft.aufirst=G&rft.date=2001-08-15&rft.volume=184&rft.issue=4&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Neisseria gonorrhoeae; Escherichia coli; Reproductive organs; Fallopian tube; Epithelium; Porins ER - TY - JOUR T1 - GM-CSF increases AP-1 DNA binding and Ref-1 amounts in human alveolar macrophages. AN - 71097815; 11509337 AB - Alveolar macrophages have been implicated in the pathogenesis of a number of acute and chronic lung disorders. A characteristic feature of many of the chronic lung diseases is that the types of macrophages in the lung change, and in most instances, the cells resemble monocyte-like cells. We have previously shown that normal human alveolar macrophages have a decreased capacity to express protein kinase C (PKC)-induced DNA binding activity of the transcription factor activator protein (AP)-1 compared with monocytes. This decrease in AP-1 DNA binding appears to be due to a defect in redox regulation of AP-1 proteins via a decrease in the redox active protein Ref-1. The hypothesis for this study is that there are factors generated during the development of chronic lung disease that increase AP-1 DNA binding activity and Ref-1 production in human alveolar macrophages. We have focused specifically on granulocyte-macrophage colony-stimulating factor (GM-CSF) as a prototype mediator that can be released by alveolar macrophages and is related to the fibrotic process in the lung. We found that after a 24-h incubation with GM-CSF, AP-1 DNA binding was significantly increased in both unstimulated, interleukin (IL)-13, and phorbol myristate acetate (PMA)-stimulated alveolar macrophages and that there was a corresponding increase in Ref-1 protein by Western blot analysis in the PMA-stimulated group. This suggests that disease-related cytokines such as GM-CSF and IL-13 may modulate AP-1 DNA binding activity in alveolar macrophages. JF - American journal of respiratory cell and molecular biology AU - Flaherty, D M AU - Monick, M M AU - Carter, A B AU - Peterson, M W AU - Hunninghake, G W AD - Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA. flahertydm@mail.medicine.uiowa.edu Y1 - 2001/08// PY - 2001 DA - August 2001 SP - 254 EP - 259 VL - 25 IS - 2 SN - 1044-1549, 1044-1549 KW - Interleukin-13 KW - 0 KW - Proto-Oncogene Proteins c-fos KW - Proto-Oncogene Proteins c-jun KW - Transcription Factor AP-1 KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - DNA KW - 9007-49-2 KW - Carbon-Oxygen Lyases KW - EC 4.2.- KW - APEX1 protein, human KW - EC 4.2.99.18 KW - DNA-(Apurinic or Apyrimidinic Site) Lyase KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Oxidation-Reduction KW - Interleukin-13 -- administration & dosage KW - Base Sequence KW - Proto-Oncogene Proteins c-fos -- metabolism KW - Humans KW - In Vitro Techniques KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Proto-Oncogene Proteins c-jun -- metabolism KW - Interleukin-13 -- pharmacology KW - Macrophages, Alveolar -- metabolism KW - Granulocyte-Macrophage Colony-Stimulating Factor -- administration & dosage KW - Carbon-Oxygen Lyases -- metabolism KW - Transcription Factor AP-1 -- metabolism KW - DNA -- metabolism KW - DNA -- genetics KW - Macrophages, Alveolar -- drug effects KW - Granulocyte-Macrophage Colony-Stimulating Factor -- pharmacology KW - Transcription Factor AP-1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71097815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=GM-CSF+increases+AP-1+DNA+binding+and+Ref-1+amounts+in+human+alveolar+macrophages.&rft.au=Flaherty%2C+D+M%3BMonick%2C+M+M%3BCarter%2C+A+B%3BPeterson%2C+M+W%3BHunninghake%2C+G+W&rft.aulast=Flaherty&rft.aufirst=D&rft.date=2001-08-01&rft.volume=25&rft.issue=2&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-11 N1 - Date created - 2001-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A neurobiological basis for substance abuse comorbidity in schizophrenia. AN - 71132078; 11526998 AB - It is commonly held that substance use comorbidity in schizophrenia represents self-medication, an attempt by patients to alleviate adverse positive and negative symptoms, cognitive impairment, or medication side effects. However, recent advances suggest that increased vulnerability to addictive behavior may reflect the impact of the neuropathology of schizophrenia on the neural circuitry mediating drug reward and reinforcement. We hypothesize that abnormalities in the hippocampal formation and frontal cortex facilitate the positive reinforcing effects of drug reward and reduce inhibitory control over drug-seeking behavior. In this model, disturbances in drug reward are mediated, in part, by dysregulated neural integration of dopamine and glutamate signaling in the nucleus accumbens resulting form frontal cortical and hippocampal dysfunction. Altered integration of these signals would produce neural and motivational changes similar to long-term substance abuse but without the necessity of prior drug exposure. Thus, schizophrenic patients may have a predilection for addictive behavior as a primary disease symptom in parallel to, and in many, cases independent from, their other symptoms. JF - Biological psychiatry AU - Chambers, R A AU - Krystal, J H AU - Self, D W AD - Ribicoff Research Facilities, West Haven Veterans Administration Hospital, Connecticut, USA. Y1 - 2001/07/15/ PY - 2001 DA - 2001 Jul 15 SP - 71 EP - 83 VL - 50 IS - 2 SN - 0006-3223, 0006-3223 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Frontal Lobe -- pathology KW - Disease Susceptibility KW - Neurobiology KW - Humans KW - Hippocampus -- metabolism KW - Frontal Lobe -- metabolism KW - Nucleus Accumbens -- metabolism KW - Dopamine -- metabolism KW - Nucleus Accumbens -- pathology KW - Hippocampus -- pathology KW - Schizophrenia -- metabolism KW - Schizophrenic Psychology KW - Substance-Related Disorders -- complications KW - Schizophrenia -- pathology KW - Schizophrenia -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71132078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=A+neurobiological+basis+for+substance+abuse+comorbidity+in+schizophrenia.&rft.au=Chambers%2C+R+A%3BKrystal%2C+J+H%3BSelf%2C+D+W&rft.aulast=Chambers&rft.aufirst=R&rft.date=2001-07-15&rft.volume=50&rft.issue=2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-10 N1 - Date created - 2001-08-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2000 Oct 1;20(19):7489-95 [11007908] Am J Psychiatry. 2001 Mar;158(3):497-8 [11229999] Med Aspects Hum Sex. 1976 Apr;10(4):32, 35, 39, passim [957810] Psychol Med. 1977 May;7(2):213-21 [560024] Pharmacol Biochem Behav. 1982 Aug;17(2):193-202 [7134232] Neuroscience. 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2017-01-18 ER - TY - JOUR T1 - Neuroprotective effects of extracellular glutamate are absent in hippocampal organotypic cultures treated with the amyloid peptide Abeta(25-35). AN - 70975819; 11430902 AB - Hippocampal cells are particularly vulnerable in Alzheimer's disease but the cause of cell death is unknown. Amyloid toxicity has been implicated in hippocampal cell death, but its specific mechanisms are poorly understood. We used confocal microscopy to examine the effects of the amyloid peptide fragment 25-35 (Abeta(25-35)) on cell death in organotypic hippocampal slice cultures. Addition of glutamate to the culture medium significantly improved nerve cell survival in cultures subjected to consecutive medium exchanges. This effect was lost if cultures were treated with the amyloid peptide fragment Abeta(25-35) but not the inactive peptide 35-25. These data suggest that one of the mechanisms responsible for amyloid toxicity may be inhibition of the survival promoting effects of extracellular glutamate. JF - Brain research AU - Baskys, A AU - Adamchik, Y AD - Department of Physiology, University of Toronto, Toronto, Ontario, M5T 2S8, Canada. andrius.baskys@med.va.gov Y1 - 2001/07/13/ PY - 2001 DA - 2001 Jul 13 SP - 188 EP - 194 VL - 907 IS - 1-2 SN - 0006-8993, 0006-8993 KW - 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one KW - 0 KW - Amyloid beta-Peptides KW - Androstadienes KW - Culture Media, Serum-Free KW - Enzyme Inhibitors KW - Flavonoids KW - Fluorescent Dyes KW - Neuroprotective Agents KW - Peptide Fragments KW - Receptors, Glutamate KW - amyloid beta-protein (25-35) KW - amyloid beta-protein (35-25) KW - Propidium KW - 36015-30-2 KW - Glutamic Acid KW - 3KX376GY7L KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - wortmannin KW - XVA4O219QW KW - Index Medicus KW - Microscopy, Confocal KW - Fluorescent Dyes -- analysis KW - MAP Kinase Signaling System -- drug effects KW - Animals KW - Extracellular Space KW - Receptors, Glutamate -- drug effects KW - Androstadienes -- pharmacology KW - Cell Death -- drug effects KW - Rats KW - Dentate Gyrus -- drug effects KW - Dentate Gyrus -- pathology KW - Propidium -- analysis KW - Rats, Wistar KW - Enzyme Inhibitors -- pharmacology KW - Alzheimer Disease -- metabolism KW - Culture Media, Serum-Free -- pharmacology KW - Flavonoids -- pharmacology KW - Organ Culture Techniques KW - Phosphatidylinositol 3-Kinases -- antagonists & inhibitors KW - Alzheimer Disease -- pathology KW - Peptide Fragments -- toxicity KW - Amyloid beta-Peptides -- toxicity KW - Peptide Fragments -- pharmacology KW - Amyloid beta-Peptides -- pharmacology KW - Hippocampus -- pathology KW - Glutamic Acid -- pharmacology KW - Neuroprotective Agents -- pharmacology KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70975819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Neuroprotective+effects+of+extracellular+glutamate+are+absent+in+hippocampal+organotypic+cultures+treated+with+the+amyloid+peptide+Abeta%2825-35%29.&rft.au=Baskys%2C+A%3BAdamchik%2C+Y&rft.aulast=Baskys&rft.aufirst=A&rft.date=2001-07-13&rft.volume=907&rft.issue=1-2&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-04 N1 - Date created - 2001-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tumor chronobiology AN - 17903617; 5175195 AB - Traditionally, drug delivery has meant getting a simple chemical absorbed predictably from the gut or from the site of injection. A second-generation drug delivery goal has been the perfection of continuous constant rate (zero-order) delivery of simple xenobiotic molecules or common hormones. Living organisms are not 'zero-order' in their requirement for or response to drugs. They are predictable resonating dynamic systems, which require different amounts of drug at predictably different times within the circadian cycle in order to maximize desired and minimize undesired drug effects. JF - Journal of Controlled Release AU - Hrushesky, WJM AD - WJB Dorn VA Medical Center, and the School of Medicine and Norman J. Arnold School of Public Health of the University of South Carolina, Columbia, SC 29209, USA, william.hrushesky@med.va.gov Y1 - 2001/07/06/ PY - 2001 DA - 2001 Jul 06 SP - 27 EP - 30 VL - 74 IS - 1-3 SN - 0168-3659, 0168-3659 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Drug delivery KW - Chronobiology KW - Xenobiotics KW - Tumors KW - Hormones KW - Controlled release KW - W3 33388:Drug delivery vehicles (liposomes, cochleates, microspheres) KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17903617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Controlled+Release&rft.atitle=Tumor+chronobiology&rft.au=Hrushesky%2C+WJM&rft.aulast=Hrushesky&rft.aufirst=WJM&rft.date=2001-07-06&rft.volume=74&rft.issue=1-3&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Journal+of+Controlled+Release&rft.issn=01683659&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Tumors; Chronobiology; Controlled release; Hormones; Xenobiotics; Drug delivery ER - TY - JOUR T1 - Multivariate Prediction of Posttraumatic Symptoms in Psychiatric Inpatients AN - 954613656; 14263051 AB - Based on a conceptual framework for the long-term effects of childhood abuse, this study examined the capacity of childhood family environment (caretaker dysfunction, neglect, perceived social support), violent abuse (physical and sexual), and individual variables (other abuse) to predict adult psychiatric symptoms of PTSD, dissociation, and depression. Complete interview data were obtained from 178 psychiatric inpatients who varied greatly on abuse status and severity. Results of multiple regressions of predictor variables onto the three outcome variables showed that the predictor variables accounted for 15% (for depression) to 42% (for PTSD) of the variance in these symptoms and that violent abuse uniquely accounted for a significant proportion of the variance in outcomes for all three of the symptom groups studied. JF - Journal of Traumatic Stress AU - Carlson, Eve B AU - Dalenberg, Constance AU - Armstrong, Judith AU - Daniels, Jill Walker AU - Loewenstein, Richard AU - Roth, David AD - Department of Veterans Affairs, National Center for PTSD, Palo Alto Health Care System, Menlo Park, California, eve.carlson@med.va.gov Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 549 EP - 567 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 14 IS - 3 SN - 0894-9867, 0894-9867 KW - Health & Safety Science Abstracts KW - posttraumatic stress disorder KW - child abuse KW - Stress KW - Children KW - depression KW - Perception KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954613656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Traumatic+Stress&rft.atitle=Multivariate+Prediction+of+Posttraumatic+Symptoms+in+Psychiatric+Inpatients&rft.au=Carlson%2C+Eve+B%3BDalenberg%2C+Constance%3BArmstrong%2C+Judith%3BDaniels%2C+Jill+Walker%3BLoewenstein%2C+Richard%3BRoth%2C+David&rft.aulast=Carlson&rft.aufirst=Eve&rft.date=2001-07-01&rft.volume=14&rft.issue=3&rft.spage=549&rft.isbn=&rft.btitle=&rft.title=Journal+of+Traumatic+Stress&rft.issn=08949867&rft_id=info:doi/10.1023%2FA%3A1011164707774 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - posttraumatic stress disorder; Perception; child abuse; Stress; Children; depression DO - http://dx.doi.org/10.1023/A:1011164707774 ER - TY - JOUR T1 - Patterns of verbal learning and memory in traumatic brain injury. AN - 85364272; pmid-11459109 AB - CVLT and WMS-R Digit Span variables were used to calculate indexes of seven specific short- and long-term memory processes: working memory span and central executive functions, and long-term memory encoding, consolidation, retention, retrieval, control abilities. Scores on these indexes were then cluster-analyzed to determine whether subtypes of memory performance exist that correspond to deficits in these theoretical memory constructs. Parallel analyses were conducted with two large samples (N = 150 and N = 151) of individuals who had sustained a traumatic brain injury (TBI). Findings showed that TBI results in subgroups of memory disorders with specific deficits in consolidation, retention, and retrieval processes. Control problems (keeping track of list versus non-list items) only appeared in conjunction with retrieval deficits. Working memory span and central executive functioning (i.e., the ability to manipulate information in working memory) do not appear to be deficits characteristic of TBI as no such clusters emerged in the analyses. By using specific indexes of memory processes, and in contrast to previous studies, patterns of memory dysfunction were found that correspond to deficits in theoretically meaningful memory constructs. JF - Journal of the International Neuropsychological Society : JINS AU - Curtiss, G AU - Vanderploeg, R D AU - Spencer, J AU - Salazar, A M AD - Defense and Veterans Head Injury Program, Walter Reed Army Medical Center, Washington, DC, USA. Glenn.Curtiss@med.va.gov Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 574 EP - 585 VL - 7 IS - 5 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Amnesia: diagnosis KW - Amnesia: psychology KW - *Brain Concussion: diagnosis KW - Brain Concussion: psychology KW - *Brain Damage, Chronic: diagnosis KW - Brain Damage, Chronic: psychology KW - *Brain Injury, Chronic: diagnosis KW - Brain Injury, Chronic: psychology KW - Female KW - Humans KW - Male KW - Middle Aged KW - *Neuropsychological Tests KW - Retention (Psychology) KW - Serial Learning KW - Verbal Learning KW - Wechsler Scales UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85364272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Patterns+of+verbal+learning+and+memory+in+traumatic+brain+injury.&rft.au=Curtiss%2C+G%3BVanderploeg%2C+R+D%3BSpencer%2C+J%3BSalazar%2C+A+M&rft.aulast=Curtiss&rft.aufirst=G&rft.date=2001-07-01&rft.volume=7&rft.issue=5&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Differential episodic and semantic memory performance in Alzheimer's disease and vascular dementias. AN - 85361051; pmid-11459108 AB - Differential performance on measures of episodic and semantic memory were examined in AD, cortical vascular dementia (CVaD), subcortica] vascular dementia (SVaD), and controls. Groups were matched on age, education, and gender; dementia groups also were matched on severity. Recognition/retrieval differences were found only between SVaD and AD groups, not between CVaD and AD. Thus, recognition/retrieval differences are likely secondary to subcortical pathology rather than to vascular etiology per se. Similarly, significant numbers of memory errors were associated with cortical pathology, regardless of etiology. Error rate differences were found only between SVaD and AD groups, not between CVaD and AD. Finally, rapid forgetting was unique to AD; however, since no difference was found between SVaD and AD, rapid forgetting may occur only as AD progresses. No semantic memory measure differentiated AD from either CVaD or SVaD subjects. Results suggest that some previously reported episodic differences may be due to cortical versus white matter subcortical pathology, rather than to AD versus vascular etiology. JF - Journal of the International Neuropsychological Society : JINS AU - Vanderploe, R D AU - Yuspeh, R L AU - Schinka, J A AD - James A. Haley VA Medical Center, Tampa, Florida 33612, USA. Rodney.Vanderploeg@med.va.gov Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 563 EP - 573 VL - 7 IS - 5 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - *Alzheimer Disease: diagnosis KW - Alzheimer Disease: psychology KW - *Dementia, Vascular: diagnosis KW - Dementia, Vascular: psychology KW - Diagnosis, Differential KW - Disease Progression KW - Female KW - Humans KW - Male KW - *Mental Recall KW - *Neuropsychological Tests: statistics & numerical data KW - Psychometrics KW - Reproducibility of Results KW - *Verbal Learning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85361051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Differential+episodic+and+semantic+memory+performance+in+Alzheimer%27s+disease+and+vascular+dementias.&rft.au=Vanderploe%2C+R+D%3BYuspeh%2C+R+L%3BSchinka%2C+J+A&rft.aulast=Vanderploe&rft.aufirst=R&rft.date=2001-07-01&rft.volume=7&rft.issue=5&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Seminal figures in the History of Movement Disorders: Hammond, Osler, and Huntington. Part 11 of the MDS-Sponsored History of Movement Disorders Exhibit, Barcelona, June 2000. AN - 85352734; pmid-11481703 JF - Movement disorders : official journal of the Movement Disorder Society AU - Lanska, D J AU - Goetz, C G AU - Chmura, T A AD - Veterans Affairs Medical Center, Great Lakes VA Healthcare System, Tomah, Wisconsin, USA. douglas.lanska@med.va.gov Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 749 EP - 753 VL - 16 IS - 4 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Canada KW - Exhibits as Topic KW - History, 19th Century KW - History, 20th Century KW - Humans KW - *Movement Disorders: history KW - Spain KW - United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85352734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Seminal+figures+in+the+History+of+Movement+Disorders%3A+Hammond%2C+Osler%2C+and+Huntington.+Part+11+of+the+MDS-Sponsored+History+of+Movement+Disorders+Exhibit%2C+Barcelona%2C+June+2000.&rft.au=Lanska%2C+D+J%3BGoetz%2C+C+G%3BChmura%2C+T+A&rft.aulast=Lanska&rft.aufirst=D&rft.date=2001-07-01&rft.volume=16&rft.issue=4&rft.spage=749&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Development of instruments for abnormal movements: dynamometers, the dynamograph, and tremor recorders. Part 9 of the MDS-Sponsored History of Movement Disorders Exhibit, Barcelona, June 2000. AN - 85352527; pmid-11481701 JF - Movement disorders : official journal of the Movement Disorder Society AU - Lanska, D J AU - Goetz, C G AU - Chmura, T A AD - Veterans Affairs Medical Center, Great Lakes VA Healthcare System, Tomah, Wisconsin, USA. douglas.lanska@med.va.gov Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 736 EP - 741 VL - 16 IS - 4 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - *Electrodiagnosis: history KW - Electrodiagnosis: instrumentation KW - Exhibits as Topic KW - History, 19th Century KW - History, 20th Century KW - Humans KW - Movement Disorders: diagnosis KW - *Movement Disorders: history KW - *Myography: history KW - Myography: instrumentation KW - *Neurologic Examination: history KW - Spain KW - Tremor: diagnosis KW - *Tremor: history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85352527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Development+of+instruments+for+abnormal+movements%3A+dynamometers%2C+the+dynamograph%2C+and+tremor+recorders.+Part+9+of+the+MDS-Sponsored+History+of+Movement+Disorders+Exhibit%2C+Barcelona%2C+June+2000.&rft.au=Lanska%2C+D+J%3BGoetz%2C+C+G%3BChmura%2C+T+A&rft.aulast=Lanska&rft.aufirst=D&rft.date=2001-07-01&rft.volume=16&rft.issue=4&rft.spage=736&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Development of instruments for abnormal movements: postural sway and gait analyses. Part 10 of the MDS-Sponsored History of Movement Disorders Exhibit, Barcelona, June 2000. AN - 85350068; pmid-11481702 JF - Movement disorders : official journal of the Movement Disorder Society AU - Lanska, D J AU - Goetz, C G AU - Chmura, T A AD - Veterans Affairs Medical Center, Great Lakes VA Healthcare System, Tomah, Wisconsin, USA. douglas.lanska@med.va.gov Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 742 EP - 748 VL - 16 IS - 4 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Exhibits as Topic KW - *Gait Apraxia: history KW - History, 19th Century KW - History, 20th Century KW - Humans KW - Movement Disorders: diagnosis KW - *Movement Disorders: history KW - *Neurologic Examination: history KW - Neurologic Examination: instrumentation KW - *Postural Balance KW - *Posture KW - Spain UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85350068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Development+of+instruments+for+abnormal+movements%3A+postural+sway+and+gait+analyses.+Part+10+of+the+MDS-Sponsored+History+of+Movement+Disorders+Exhibit%2C+Barcelona%2C+June+2000.&rft.au=Lanska%2C+D+J%3BGoetz%2C+C+G%3BChmura%2C+T+A&rft.aulast=Lanska&rft.aufirst=D&rft.date=2001-07-01&rft.volume=16&rft.issue=4&rft.spage=742&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Prognosis for papillary serous carcinoma of the endometrium after surgical staging. AN - 71121013; 11520370 AB - To investigate the pattern of failure and the prognosis following pathological staging for uterine papillary serous carcinoma (UPSC). A retrospective review was conducted of 22 patients with UPSC, treated between 1989 and 1998 at a single institution. All patients were surgically staged. Two patients with advanced disease received chemotherapy only. Two patients with early-stage disease were followed without further treatment. Eighteen patients received postoperative irradiation; eight patients received whole abdominal irradiation (WART), and the remaining 10 patients, pelvic irradiation (PRT). In addition, seven of these patients received vaginal cuff irradiation with low-dose-rate or high-dose-rate brachytherapy. Toxicity, pattern of failure, and survival were evaluated and compared to the literature. Seven patients (32%) developed distant metastases, three out of seven (42%) after WART. Four out of seven patients who had distant metastases died from disease progression during subsequent chemotherapy. All patients with distant metastases had locally advanced-stage disease at presentation (six stage III, one stage IV). Four patients with pelvic recurrences developed concurrent (2) and subsequent (2) distant metastases. Three patients had isolated distant metastases. No patient with early stage-disease (stage I and II) died from disease progression. Pathological staging should be performed for all patients with UPSC to determine the prognosis as well as to tailor the treatment. The role of abdominal irradiation in the treatment of UPSC is yet to be determined; however, such an approach may not be necessary for the control of disease for patients with early-stage (I and II) disease. Patients with locally advanced-stage (stage III) disease are at risk of local regional failures and distant metastases despite WART. Therefore, the benefit of WART for advanced-stage disease is also questionable. Paclitaxel-based chemotherapy is currently being investigated in this setting. JF - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society AU - Nguyen, N P AU - Sallah, S AU - Karlsson, U AU - Vos, P AU - Ludin, A AU - Semer, D AU - Tait, D AU - Salehpour, M AU - Jendrasiak, G AU - Robiou, C AD - Department of Radiation Oncology, Southwestern University, Dallas, Texas 75216, USA. NamPhong.Nguyen@med.va.gov PY - 2001 SP - 305 EP - 311 VL - 11 IS - 4 SN - 1048-891X, 1048-891X KW - Index Medicus KW - Neoplasm Staging KW - Aged, 80 and over KW - Humans KW - North Carolina KW - Treatment Outcome KW - Retrospective Studies KW - Prognosis KW - Aged KW - Middle Aged KW - Female KW - Survival Analysis KW - Endometrial Neoplasms -- radiotherapy KW - Endometrial Neoplasms -- pathology KW - Carcinoma, Papillary -- surgery KW - Carcinoma, Papillary -- pathology KW - Carcinoma, Papillary -- radiotherapy KW - Carcinoma, Papillary -- mortality KW - Endometrial Neoplasms -- mortality KW - Endometrial Neoplasms -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71121013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+gynecological+cancer+%3A+official+journal+of+the+International+Gynecological+Cancer+Society&rft.atitle=Prognosis+for+papillary+serous+carcinoma+of+the+endometrium+after+surgical+staging.&rft.au=Nguyen%2C+N+P%3BSallah%2C+S%3BKarlsson%2C+U%3BVos%2C+P%3BLudin%2C+A%3BSemer%2C+D%3BTait%2C+D%3BSalehpour%2C+M%3BJendrasiak%2C+G%3BRobiou%2C+C&rft.aulast=Nguyen&rft.aufirst=N&rft.date=2001-07-01&rft.volume=11&rft.issue=4&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=International+journal+of+gynecological+cancer+%3A+official+journal+of+the+International+Gynecological+Cancer+Society&rft.issn=1048891X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-04 N1 - Date created - 2001-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of quetiapine in delirium: case reports. AN - 71076614; 11496025 JF - Psychosomatics AU - Torres, R AU - Mittal, D AU - Kennedy, R AD - University of Mississippi School of Medicine, Jackson, USA. rafael.torres@med.va.gov PY - 2001 SP - 347 EP - 349 VL - 42 IS - 4 SN - 0033-3182, 0033-3182 KW - Dibenzothiazepines KW - 0 KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Treatment Outcome KW - Referral and Consultation KW - Middle Aged KW - Male KW - Postoperative Complications -- drug therapy KW - Delirium -- etiology KW - Dibenzothiazepines -- adverse effects KW - Patient Care Team KW - Postoperative Complications -- etiology KW - Dibenzothiazepines -- therapeutic use KW - Delirium -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71076614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatics&rft.atitle=Use+of+quetiapine+in+delirium%3A+case+reports.&rft.au=Torres%2C+R%3BMittal%2C+D%3BKennedy%2C+R&rft.aulast=Torres&rft.aufirst=R&rft.date=2001-07-01&rft.volume=42&rft.issue=4&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Psychosomatics&rft.issn=00333182&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-04 N1 - Date created - 2001-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Failure of tolterodine to treat clozapine-induced nocturnal enuresis. AN - 71060040; 11485135 AB - To report the use and subsequent failure of the bladder-selective agent tolterodine, to treat clozapine-induced nocturnal enuresis in an adolescent patient with psychotic illness. A 16-year-old Hispanic girl was admitted to the state psychiatric hospital with a diagnosis of bipolar disorder with psychotic features. Clozapine therapy was initiated, and after three months of treatment the patient began experiencing episodes of nocturnal enuresis. The bladder-selective agent tolterodine was tried and subsequently failed to resolve the enuresis episodes. Desmopressin was initiated, which resulted in amelioration of symptoms. This is the first published report of using tolterodine to treat clozapine-induced nocturnal enuresis. Several methods to decrease clozapine-induced urinary incontinence have been used and typically include the addition of agents with high anticholinergic properties. Tolterodine is a bladder-selective anticholinergic agent indicated for the treatment of urinary urge incontinence and may be employed as a treatment for antipsychotic-induced incontinence. Nocturnal enuresis is an adverse effect that infrequently occurs with use of clozapine therapy. Although tolterodine was ineffective in our patient to treat clozapine-induced nocturnal enuresis, further trials are required to appropriately evaluate the effectiveness of tolterodine to treat this adverse drug reaction. JF - The Annals of pharmacotherapy AU - English, B A AU - Still, D J AU - Harper, J AU - Saklad, S R AD - Veterans Affairs Medical Center, Tuscaloosa, AL, USA. brett.english@med.va.gov PY - 2001 SP - 867 EP - 869 VL - 35 IS - 7-8 SN - 1060-0280, 1060-0280 KW - Antipsychotic Agents KW - 0 KW - Benzhydryl Compounds KW - Cresols KW - Muscarinic Antagonists KW - Phenylpropanolamine KW - 33RU150WUN KW - Tolterodine Tartrate KW - 5T619TQR3R KW - Clozapine KW - J60AR2IKIC KW - Index Medicus KW - Treatment Failure KW - Humans KW - Adolescent KW - Female KW - Psychotic Disorders -- drug therapy KW - Muscarinic Antagonists -- therapeutic use KW - Benzhydryl Compounds -- therapeutic use KW - Enuresis -- chemically induced KW - Clozapine -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Enuresis -- drug therapy KW - Cresols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71060040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Failure+of+tolterodine+to+treat+clozapine-induced+nocturnal+enuresis.&rft.au=English%2C+B+A%3BStill%2C+D+J%3BHarper%2C+J%3BSaklad%2C+S+R&rft.aulast=English&rft.aufirst=B&rft.date=2001-07-01&rft.volume=35&rft.issue=7-8&rft.spage=867&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-11 N1 - Date created - 2001-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Organizational culture, continuous quality improvement, and medication administration error reporting. AN - 71057040; 11477957 AB - This study explores the relationships among measures of nurses' perceptions of organizational culture, continuous quality improvement (CQI) implementation, and medication administration error (MAE) reporting. Hospital-based nurses were surveyed using measures of organizational culture and CQI implementation. These data were combined with previously collected data on perceptions of MAE reporting. A group-oriented culture had a significant positive correlation with CQI implementation, whereas hierarchical and rational culture types were negatively correlated with CQI implementation. Higher barriers to reporting MAE were associated with lower perceived reporting rates. A group-oriented culture and a greater extent of CQI implementation were positively (but not significantly) associated with the estimated overall percentage of MAEs reported. We conclude that health care organizations have implemented CQI programs, yet barriers remain relative to MAE reporting. There is a need to assess the reliability, validity, and completeness of key quality assessment and risk management data. JF - American journal of medical quality : the official journal of the American College of Medical Quality AU - Wakefield, B J AU - Blegen, M A AU - Uden-Holman, T AU - Vaughn, T AU - Chrischilles, E AU - Wakefield, D S AD - Iowa City VA Medical Center, 601 Hwy 6 W, Iowa City, IA 52246, USA. bonnie.wakefield@med.va.gov PY - 2001 SP - 128 EP - 134 VL - 16 IS - 4 SN - 1062-8606, 1062-8606 KW - Index Medicus KW - United States KW - Humans KW - Data Collection KW - Adverse Drug Reaction Reporting Systems -- utilization KW - Nursing Staff, Hospital KW - Attitude of Health Personnel KW - Medication Errors -- prevention & control KW - Organizational Culture KW - Total Quality Management -- organization & administration KW - Risk Management -- utilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71057040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+medical+quality+%3A+the+official+journal+of+the+American+College+of+Medical+Quality&rft.atitle=Organizational+culture%2C+continuous+quality+improvement%2C+and+medication+administration+error+reporting.&rft.au=Wakefield%2C+B+J%3BBlegen%2C+M+A%3BUden-Holman%2C+T%3BVaughn%2C+T%3BChrischilles%2C+E%3BWakefield%2C+D+S&rft.aulast=Wakefield&rft.aufirst=B&rft.date=2001-07-01&rft.volume=16&rft.issue=4&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=American+journal+of+medical+quality+%3A+the+official+journal+of+the+American+College+of+Medical+Quality&rft.issn=10628606&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-23 N1 - Date created - 2001-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pilot trial of indinavir, ritonavir, didanosine, and lamivudine in a once-daily four-drug regimen for HIV infection. AN - 71015082; 11464145 AB - To evaluate the tolerance, pharmacokinetics, and virologic and immunologic outcomes of once-daily indinavir, ritonavir, didanosine, and lamivudine in HIV-seropositive individuals. Open-label 24-week pilot study. Ten HIV-seropositive subjects who were either antiretroviral-naive or minimally experienced with short-term single-or dual-nucleoside therapy provided informed consent and were enrolled. All subjects received didanosine (400 mg) 30 to 60 minutes before a meal followed by indinavir (1200 mg), ritonavir (400 mg), and lamivudine (300 mg) concurrent with the aforementioned meal. Safety laboratory tests, including a complete blood cell count and amylase, lipase, liver transaminase, and nonfasting lipid monitoring as well as plasma HIV viral load and CD4+ lymphocyte count, were carried out at monthly intervals. Genotyping was performed at baseline. Pharmacokinetic studies for indinavir and ritonavir were performed at week 8. Nine of 10 subjects completed 24 weeks of therapy. No subject demonstrated primary protease inhibitor mutations at baseline. Toxicities experienced by subjects were typically mild and consistent with those commonly reported for each of the medications, including two cases of hematuria. By week 24, median nonfasting cholesterol and triglyceride levels increased by 49% and 108%, respectively. Median baseline plasma HIV viral load and CD4+ lymphocyte count were 29,292 (4.47 log10) copies/ml and 224 cells/mm3, respectively. Eight of 10 subjects had a plasma HIV viral load of <50 copies/ml by week 12. The 2 subjects with a detectable HIV viral load reached <50 copies/ml by week 28. Median CD4+ lymphocyte counts increased by 193 cells/mm3 at week 24. Indinavir and ritonavir plasma concentrations remained above respective inhibitory and effective concentrations (IC95 and EC50) (uncorrected for protein binding) throughout the 24-hour dosing interval for 6 of 10 and 8 of 10 subjects, respectively. Our pilot study demonstrates excellent virologic suppression despite low minimum protease inhibitor concentrations during a dosing interval in some patients and is supportive of further study. JF - Journal of acquired immune deficiency syndromes (1999) AU - Mole, L AU - Schmidgall, D AU - Holodniy, M AD - Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA. larry.mole@med.va.gov Y1 - 2001/07/01/ PY - 2001 DA - 2001 Jul 01 SP - 260 EP - 265 VL - 27 IS - 3 SN - 1525-4135, 1525-4135 KW - Anti-HIV Agents KW - 0 KW - HIV Protease Inhibitors KW - Triglycerides KW - Lamivudine KW - 2T8Q726O95 KW - Indinavir KW - 5W6YA9PKKH KW - Cholesterol KW - 97C5T2UQ7J KW - Didanosine KW - K3GDH6OH08 KW - Ritonavir KW - O3J8G9O825 KW - Index Medicus KW - AIDS/HIV KW - Triglycerides -- blood KW - Humans KW - Indinavir -- therapeutic use KW - Lamivudine -- therapeutic use KW - Pilot Projects KW - CD4 Lymphocyte Count KW - Indinavir -- adverse effects KW - Didanosine -- adverse effects KW - Ritonavir -- therapeutic use KW - Adult KW - Indinavir -- pharmacokinetics KW - Treatment Outcome KW - Ritonavir -- adverse effects KW - Male KW - Ritonavir -- pharmacokinetics KW - Lamivudine -- adverse effects KW - Safety KW - Didanosine -- pharmacokinetics KW - Viral Load KW - Genotype KW - Drug Therapy, Combination KW - Drug Evaluation KW - Didanosine -- therapeutic use KW - Cholesterol -- blood KW - Lamivudine -- pharmacokinetics KW - Middle Aged KW - Anti-HIV Agents -- pharmacokinetics KW - HIV Infections -- virology KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- immunology KW - HIV Infections -- drug therapy KW - Anti-HIV Agents -- adverse effects KW - HIV Protease Inhibitors -- pharmacokinetics KW - HIV Protease Inhibitors -- therapeutic use KW - HIV Protease Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71015082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=A+pilot+trial+of+indinavir%2C+ritonavir%2C+didanosine%2C+and+lamivudine+in+a+once-daily+four-drug+regimen+for+HIV+infection.&rft.au=Mole%2C+L%3BSchmidgall%2C+D%3BHolodniy%2C+M&rft.aulast=Mole&rft.aufirst=L&rft.date=2001-07-01&rft.volume=27&rft.issue=3&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=15254135&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-09 N1 - Date created - 2001-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fenofibrate and warfarin interaction. AN - 70984060; 11444587 AB - A 79-year-old man with atrial fibrillation and coronary heart disease who was taking warfarin (Coumadin) was converted to fenofibrate from gemfibrozil therapy for persistently elevated triglyceride levels. The patient took fenofibrate for 1 month and subsequently experienced rectal bleeding that required a visit to the emergency room. Before starting fenofibrate therapy, his coagulation values were within therapeutic range, but when measured in the emergency room the international normalized ratio (INR) was grossly elevated. The patient denied any changes in diet, alcohol ingestion, compliance with therapy, or use of other new drugs except for fenofibrate. His drug therapy profile consisted of digoxin, fosinopril, and furosemide for chronic heart failure, allopurinol for gout, and potassium supplementation. To minimize the risk of supratherapeutic INR values and/or hemorrhagic events, clinicians should perform serial monitoring of INR when initiating fenofibrate therapy in a patient previously stabilized on a coumarin anticoagulant. JF - Pharmacotherapy AU - Aldridge, M A AU - Ito, M K AD - University of Pacific, Stockton, California, and Veterans Administration San Diego Healthcare System, USA. Y1 - 2001/07// PY - 2001 DA - July 2001 SP - 886 EP - 889 VL - 21 IS - 7 SN - 0277-0008, 0277-0008 KW - Anticoagulants KW - 0 KW - Hypolipidemic Agents KW - Warfarin KW - 5Q7ZVV76EI KW - Fenofibrate KW - U202363UOS KW - Index Medicus KW - Blood Coagulation -- physiology KW - Humans KW - Blood Coagulation -- drug effects KW - International Normalized Ratio KW - Aged KW - Drug Synergism KW - Male KW - Drug Interactions -- physiology KW - Anticoagulants -- pharmacokinetics KW - Warfarin -- pharmacokinetics KW - Fenofibrate -- pharmacokinetics KW - Hypolipidemic Agents -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70984060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Fenofibrate+and+warfarin+interaction.&rft.au=Aldridge%2C+M+A%3BIto%2C+M+K&rft.aulast=Aldridge&rft.aufirst=M&rft.date=2001-07-01&rft.volume=21&rft.issue=7&rft.spage=886&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase I study of anti--epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer. AN - 70978686; 11432891 AB - To evaluate the safety, pharmacokinetics, and efficacy of a chimeric anti-epidermal growth factor receptor monoclonal antibody, cetuximab, in combination with radiation therapy (RT) in patients with advanced squamous cell carcinoma of the head and neck. We treated 16 patients in five successive treatment schedules. A standard dose escalation procedure was used; three patients entered onto the study at each dose level of cetuximab received conventional RT (70 Gy, 2 Gy/d), and the final three patients received hyperfractionated RT (76.8 Gy, 1.2 Gy bid). Cetuximab was delivered as a loading dose of 100 to 500 mg/m(2), followed by weekly infusions of 100 to 250 mg/m(2) for 7 to 8 weeks. Circulating levels of cetuximab during therapy were determined using a biomolecular interaction analysis core instrument. Human antichimeric antibody response was evaluated with a double-antigen radiometric assay. The recommended phase II/III dose was defined as the optimal cetuximab dose level based on the pharmacologic parameters and adverse events. The most commonly reported adverse events were fever, asthenia, transaminase elevation, nausea, and skin toxicities (grade 1 to 2 in most patients). Skin toxicity outside of the RT field was not strictly dose-dependent; however, grade 2 or higher events were observed in patients treated with higher dose regimens. There was one grade 4 allergic reaction. Most acute adverse effects were associated with RT (xerostomia, mucositis, and local skin toxicity). No antibodies against cetuximab were detected. All patients achieved an objective response (13 complete and two partial remissions). Cetuximab can be safely administered with RT. The recommended dose for phase II/III studies is a loading dose of 400 to 500 mg/m(2) and a maintenance weekly dose of 250 mg/m(2). JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Robert, F AU - Ezekiel, M P AU - Spencer, S A AU - Meredith, R F AU - Bonner, J A AU - Khazaeli, M B AU - Saleh, M N AU - Carey, D AU - LoBuglio, A F AU - Wheeler, R H AU - Cooper, M R AU - Waksal, H W AD - Division of Hematology/Oncology, Department of Radiation Oncology, Comprehensive Cancer Center, University of Alabama at Birmingham, and Birmingham Veterans Administration, 35294-3330, USA. pacorobertuab@cs.com Y1 - 2001/07/01/ PY - 2001 DA - 2001 Jul 01 SP - 3234 EP - 3243 VL - 19 IS - 13 SN - 0732-183X, 0732-183X KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antineoplastic Agents KW - Cetuximab KW - PQX0D8J21J KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Combined Modality Therapy KW - Humans KW - Adult KW - Metabolic Clearance Rate KW - Aged KW - Middle Aged KW - Male KW - Female KW - Head and Neck Neoplasms -- therapy KW - Radiotherapy -- methods KW - Antibodies, Monoclonal -- pharmacology KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Carcinoma, Squamous Cell -- therapy KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70978686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+I+study+of+anti--epidermal+growth+factor+receptor+antibody+cetuximab+in+combination+with+radiation+therapy+in+patients+with+advanced+head+and+neck+cancer.&rft.au=Robert%2C+F%3BEzekiel%2C+M+P%3BSpencer%2C+S+A%3BMeredith%2C+R+F%3BBonner%2C+J+A%3BKhazaeli%2C+M+B%3BSaleh%2C+M+N%3BCarey%2C+D%3BLoBuglio%2C+A+F%3BWheeler%2C+R+H%3BCooper%2C+M+R%3BWaksal%2C+H+W&rft.aulast=Robert&rft.aufirst=F&rft.date=2001-07-01&rft.volume=19&rft.issue=13&rft.spage=3234&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-19 N1 - Date created - 2001-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Trauma, symptoms of posttraumatic stress disorder, and associated problems among incarcerated veterans. AN - 70966460; 11433115 AB - To help improve treatment for incarcerated veterans, the study examined exposure to trauma, symptoms of posttraumatic stress disorder (PTSD), functional status, and treatment history in a group of incarcerated veterans. A convenience sample of 129 jailed veterans who agreed to receive outreach contact completed the Life Event History Questionnaire, the PTSD Checklist-Civilian Version (PCL-C), and the Addiction Severity Index. Participants who had scores of 50 or above on the PCL-C, designated as screening positive for PTSD, were compared with those whose scores were below 50, designated as screening negative for PTSD. Some 112 veterans (87 percent) reported traumatic experiences. A total of 51 veterans (39 percent) screened positive for PTSD, and 78 veterans (60 percent) screened negative. Compared with veterans who screened negative for PTSD, those who screened positive reported a greater variety of traumas; more serious current legal problems; a higher lifetime use of alcohol, cocaine, and heroin; higher recent expenditures on drugs; more psychiatric symptoms; and worse general health despite more previous psychiatric and medical treatment as well as treatment for substance abuse. The findings encourage the development of an improved treatment model to keep jailed veterans with PTSD from repeated incarceration. JF - Psychiatric services (Washington, D.C.) AU - Saxon, A J AU - Davis, T M AU - Sloan, K L AU - McKnight, K M AU - McFall, M E AU - Kivlahan, D R AD - Center of Excellence in Substance Abuse Treatment and Education in Seatle, USA. andrew.saxon@med.va.gov Y1 - 2001/07// PY - 2001 DA - July 2001 SP - 959 EP - 964 VL - 52 IS - 7 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - Washington -- epidemiology KW - Humans KW - Health Status KW - Adult KW - Sampling Studies KW - Middle Aged KW - Male KW - Comorbidity KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Prisons KW - Veterans -- statistics & numerical data KW - Stress Disorders, Post-Traumatic -- therapy KW - Stress Disorders, Post-Traumatic -- psychology KW - Life Change Events KW - Substance-Related Disorders -- etiology KW - Veterans -- psychology KW - Crime -- statistics & numerical data KW - Crime -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70966460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Trauma%2C+symptoms+of+posttraumatic+stress+disorder%2C+and+associated+problems+among+incarcerated+veterans.&rft.au=Saxon%2C+A+J%3BDavis%2C+T+M%3BSloan%2C+K+L%3BMcKnight%2C+K+M%3BMcFall%2C+M+E%3BKivlahan%2C+D+R&rft.aulast=Saxon&rft.aufirst=A&rft.date=2001-07-01&rft.volume=52&rft.issue=7&rft.spage=959&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-30 N1 - Date created - 2001-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ventral incisional hernia recurrence. AN - 70960403; 11421601 AB - During the period October 1993 to December 1996, 31 patients were operated on by the author for primary or recurrent ventral incisional hernia (VIH). Three patients were excluded from analysis because their records were unavailable for review. The median age of the 28 remaining patients at their initial procedure was 57.5 years (range, 37-78 years). The repair was performed with interrupted O-Ethibond sutures in all but 3 cases where Prolene suture was used secondary to noniatrogenic contamination or recurrent hernia. There were no unplanned enterotomies in the entire series and prophylactic intravenous antibiotics were used in all cases. The only significant complications were skin hyperemia after five repairs in 3 patients who were treated empirically with intravenous antibiotics, and 1 patient who had an antibiotic-associated rash. There were no 30-day mortalities. Prolene mesh was used exclusively in all repairs performed with mesh. Seven of these repairs (25%) were for recurrent VIH. Three of these seven patients had previous mesh repairs. Six of these seven patients who presented with recurrent VIH had a mesh repair and four developed a recurrence. Five of seven were active smokers, with one having severe obstructive lung disease. Four of seven related significant occupational lifting. Of the 21 patients having initial repair of VIH, mesh was used in 8 (38%). After a median follow-up of 13 months, there were 2 recurrent hernias (25%). The remaining 13 patients had primary closure of their hernias. After median follow-up of 25 months, there were 5 recurrences (38%). A total of 34 VIH repairs were performed on these 28 patients, of which 13 were for recurrent hernias. Five of thirteen (38%) of the mesh repairs for recurrent VIH failed. The median body mass index (BMI) for the 13 patients having primary repair was 26.4, and that for all 21 cases having mesh repair was 28.8. Patients with recurrent VIH frequently recur despite use of mesh, avoidance of contamination, and consistent technique. No difference in BMI was apparent in those who recurred. Continued smoking and occupational lifting may be important risk factors for recurrent VIH. Copyright 2001 Academic Press. JF - The Journal of surgical research AU - Clark, J L AD - Surgery Service, Department of Veterans Affairs, Minneapolis Veterans Administration Medical Center, One Veterans Drive, Minneapolis, Minnesota 55417, USA. Y1 - 2001/07// PY - 2001 DA - July 2001 SP - 33 EP - 39 VL - 99 IS - 1 SN - 0022-4804, 0022-4804 KW - Ethibond KW - 0 KW - Polyethylene Terephthalates KW - Polypropylenes KW - Index Medicus KW - Sutures KW - Humans KW - Occupational Diseases -- etiology KW - Retrospective Studies KW - Smoking -- adverse effects KW - Aged KW - Recurrence KW - Risk Factors KW - Adult KW - Treatment Outcome KW - Follow-Up Studies KW - Middle Aged KW - Weight Lifting KW - Surgical Mesh KW - Male KW - Hernia, Ventral -- etiology KW - Hernia, Ventral -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70960403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+surgical+research&rft.atitle=Ventral+incisional+hernia+recurrence.&rft.au=Clark%2C+J+L&rft.aulast=Clark&rft.aufirst=J&rft.date=2001-07-01&rft.volume=99&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+surgical+research&rft.issn=00224804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-02 N1 - Date created - 2001-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Loop diuretic infusion increases thiazide-sensitive Na(+)/Cl(-)-cotransporter abundance: role of aldosterone. AN - 70949813; 11423562 AB - Chronic infusion of loop diuretics into animals induces structural and functional changes in the distal nephron. These changes include increases in the activity of the thiazide-sensitive Na(+)/Cl(-)-cotransporter (NCC). The NCC was recently demonstrated to be an aldosterone-induced protein. These experiments were designed to test the hypotheses that chronic loop diuretic infusion, with replacement of NaCl losses, increases NCC protein abundance and that this effect results, in part, from stimulation by aldosterone. Sprague-Dawley rats received vehicle (group 1), furosemide (22 mg/100 g body wt per d) (group 2), or furosemide plus spironolactone (22 and 20 mg/100 g body wt per d, respectively) (group 3). Urine output was higher for groups 2 and 3 than for group 1 (151 +/- 32, 149 +/- 24, and 12 +/- 4 ml, respectively; P 0.05, NS) These results indicate that increased NCC activity during chronic loop diuretic infusion is associated with increases in NCC protein abundance. A portion of the furosemide effect can be prevented by blockade of mineralocorticoid receptors. JF - Journal of the American Society of Nephrology : JASN AU - Abdallah, J G AU - Schrier, R W AU - Edelstein, C AU - Jennings, S D AU - Wyse, B AU - Ellison, D H AD - Division of Nephrology and Hypertension, University of Colorado School of Medicine and Veterans Administration Medical Center, Denver, Colorado, USA. Y1 - 2001/07// PY - 2001 DA - July 2001 SP - 1335 EP - 1341 VL - 12 IS - 7 SN - 1046-6673, 1046-6673 KW - Carrier Proteins KW - 0 KW - Diuretics KW - RNA, Messenger KW - Receptors, Drug KW - Slc12a3 protein, rat KW - Sodium Chloride Symporters KW - Solute Carrier Family 12, Member 3 KW - Symporters KW - thiazide receptor KW - Spironolactone KW - 27O7W4T232 KW - Aldosterone KW - 4964P6T9RB KW - Furosemide KW - 7LXU5N7ZO5 KW - Index Medicus KW - Rats KW - Metabolism -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - RNA, Messenger -- metabolism KW - Drug Synergism KW - Male KW - Spironolactone -- pharmacology KW - Receptors, Drug -- genetics KW - Receptors, Drug -- metabolism KW - Carrier Proteins -- metabolism KW - Carrier Proteins -- genetics KW - Diuretics -- pharmacology KW - Furosemide -- pharmacology KW - Aldosterone -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70949813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=Loop+diuretic+infusion+increases+thiazide-sensitive+Na%28%2B%29%2FCl%28-%29-cotransporter+abundance%3A+role+of+aldosterone.&rft.au=Abdallah%2C+J+G%3BSchrier%2C+R+W%3BEdelstein%2C+C%3BJennings%2C+S+D%3BWyse%2C+B%3BEllison%2C+D+H&rft.aulast=Abdallah&rft.aufirst=J&rft.date=2001-07-01&rft.volume=12&rft.issue=7&rft.spage=1335&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-30 N1 - Date created - 2001-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Attachment Style Classification and Posttraumatic Stress Disorder in Former Prisoners of War AN - 61508695; 200104424 AB - Adult attachment style & posttraumatic stress disorder (PTSD) symptomatology were investigated in 107 former prisoner of war veterans. Those with secure attachment styles scored significantly lower on measures of PTSD than did those with insecure styles, & attachment style was a stronger predictor of PTSD symptom intensity than was trauma severity. The suggested association between attachment style & PTSD's development & persistence are discussed in relation to research & clinical practice. 2 Tables, 24 References. Adapted from the source document. JF - American Journal of Orthopsychiatry AU - Dieperink, Michael AU - Leskela, Jennie AU - Thuras, Paul AU - Engdahl, Brian AD - c/o Leskela -- Dept Veterans Affairs Medical Center, Minneapolis, MN Y1 - 2001/07// PY - 2001 DA - July 2001 SP - 374 EP - 378 VL - 71 IS - 3 SN - 0002-9432, 0002-9432 KW - Veterans KW - Attachment KW - Prisoners of War KW - Posttraumatic Stress Disorder KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61508695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Orthopsychiatry&rft.atitle=Attachment+Style+Classification+and+Posttraumatic+Stress+Disorder+in+Former+Prisoners+of+War&rft.au=Dieperink%2C+Michael%3BLeskela%2C+Jennie%3BThuras%2C+Paul%3BEngdahl%2C+Brian&rft.aulast=Dieperink&rft.aufirst=Michael&rft.date=2001-07-01&rft.volume=71&rft.issue=3&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Orthopsychiatry&rft.issn=00029432&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJORAG N1 - SubjectsTermNotLitGenreText - Attachment; Posttraumatic Stress Disorder; Veterans; Prisoners of War ER - TY - JOUR T1 - Longitudinal follow-up of depressive symptoms among normal versus cognitively impaired elderly AN - 21105810; 11319089 AB - Objectives This prospectively designed longitudinal study assesses prevalence, incidence and prognosis of depressive symptoms among cognitively normal elderly volunteers compared with patients with mild cognitive impairment (MCI), dementia of Alzheimer type (DAT), and vascular dementia (VAD). Possible relationships between depressive symptoms, cognitive performance, disease types, and effects of antidepressant treatment were analyzed. Methods Two hundred and ninety four subjects exhibiting different levels of cognitive performance were admitted to this study. Demographics, cardiovascular and neurodegenerative risk factors, together with measures of neuropsychological test performance, were obtained at sequential visits. Depressive symptoms were selectively treated with antidepressant medications. Results One hundred and forty six subjects with normal cognition, 19 subjects with MCI, 42 patients with DAT, and 32 patients with VAD were followed for a mean of 3.5 years. With the passage of time, there were trends showing prevalence of depressive symptoms to decrease among DAT and to increase among VAD patients. VAD patients exhibited the highest incidences of new-onset depressive symptoms, followed in incidence by DAT and MCI groups. Depressive symptoms among VAD and MCI patients were more persistent and refractory to antidepressant medications than for DAT patients. Trends suggested that antidepressant treatment might benefit MCI and VAD subjects more than DAT patients. Motivationally related depressive symptoms accounted for major components of elevated Hamilton depression rating scale scores. Conclusions Depressive symptoms among DAT patients have higher rates of spontaneous resolution, without requiring intensive drug treatment, than among VAD patients in whom depressive symptoms are more persistent and refractory to drug treatment. Early depressive symptoms among subjects with MCI may represent a preclinical sign and should be considered as a risk factor for impending DAT or VAD among the elderly. JF - International Journal of Geriatric Psychiatry AU - Li, Yan-Sheng AU - Meyer, John S AU - Thornby, John AD - Cerebrovascular Research Laboratories, Veterans Administration Medical Center, Houston, TX, USA and Department of Neurology, Baylor College of Medicine, Houston, TX, USA, jmeyer@bcm.tmc.edu Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 718 EP - 727 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 16 IS - 7 SN - 0885-6230, 0885-6230 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - demography KW - Alzheimer's disease KW - vascular dementia KW - Demography KW - Risk factors KW - antidepressants KW - Dementia disorders KW - Geriatrics KW - Drugs KW - Depression KW - Prognosis KW - depression KW - Neurodegenerative diseases KW - Antidepressants KW - cognitive ability KW - Cognitive ability KW - dementia disorders KW - Cardiovascular diseases KW - elderly KW - longitudinal studies KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21105810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Geriatric+Psychiatry&rft.atitle=Longitudinal+follow-up+of+depressive+symptoms+among+normal+versus+cognitively+impaired+elderly&rft.au=Li%2C+Yan-Sheng%3BMeyer%2C+John+S%3BThornby%2C+John&rft.aulast=Li&rft.aufirst=Yan-Sheng&rft.date=2001-07-01&rft.volume=16&rft.issue=7&rft.spage=718&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Geriatric+Psychiatry&rft.issn=08856230&rft_id=info:doi/10.1002%2Fgps.423 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Depression; Alzheimer's disease; Prognosis; vascular dementia; Demography; Antidepressants; Neurodegenerative diseases; Cognitive ability; Risk factors; Dementia disorders; Geriatrics; Cardiovascular diseases; Drugs; demography; cognitive ability; antidepressants; dementia disorders; elderly; depression; longitudinal studies DO - http://dx.doi.org/10.1002/gps.423 ER - TY - JOUR T1 - Decreased expression of the NADH:ubiquinone oxidoreductase (complex I) subunit 4 in 1-methyl-4-phenylpyridinium -treated human neuroblastoma SH-SY5Y cells. AN - 70920770; 11406316 AB - Oxidative stress and mitochondrial dysfunction have been implicated in Parkinson's disease (PD) pathology. NADH:ubiquinone oxidoreductase (complex I) (EC 1.6.99.3) enzyme activity is aberrant in both PD and 1-methyl-4-phenylpyridinium (MPP(+)) models of PD. Reverse transcription polymerase chain reaction of RNA isolated from MPP(+)-treated human neuroblastoma SH-SY5Y cells identified changes in steady-state mRNA levels of the mitochondrial transcript for subunit 4 of complex I (ND4). Expression of ND4 decreased to nearly 50% after 72 h of MPP(+) (1 mM) exposure. The expression of other mitochondrial transcripts did not change significantly under the same conditions. Pre-incubation of cells with the free-radical spin-trap, N-tert-butyl-alpha-(2-sulfophenyl)-nitrone prior to MPP(+) exposure, prevented decreases in cell viability and ND4 expression. This suggests that functional defects in complex I enzyme activity in PD and MPP(+) toxicity may result from changes in steady-state mRNA levels and that free radicals may be important in this process. JF - Neuroscience letters AU - Conn, K J AU - Ullman, M D AU - Eisenhauer, P B AU - Fine, R E AU - Wells, J M AD - Department of Veterans Affairs, VA Medical Center, 200 Springs Road, Bedford, MA 01730, USA. conn.kelly_j@bedford.va.gov Y1 - 2001/06/29/ PY - 2001 DA - 2001 Jun 29 SP - 145 EP - 148 VL - 306 IS - 3 SN - 0304-3940, 0304-3940 KW - Herbicides KW - 0 KW - RNA, Messenger KW - NADH, NADPH Oxidoreductases KW - EC 1.6.- KW - Electron Transport Complex I KW - EC 1.6.5.3 KW - 1-Methyl-4-phenylpyridinium KW - R865A5OY8J KW - Index Medicus KW - Tumor Cells, Cultured KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Mitochondria -- enzymology KW - Humans KW - Parkinson Disease -- metabolism KW - RNA, Messenger -- analysis KW - Neuroblastoma KW - NADH, NADPH Oxidoreductases -- genetics KW - 1-Methyl-4-phenylpyridinium -- toxicity KW - Neurons -- drug effects KW - Neurons -- physiology KW - Herbicides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70920770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Decreased+expression+of+the+NADH%3Aubiquinone+oxidoreductase+%28complex+I%29+subunit+4+in+1-methyl-4-phenylpyridinium+-treated+human+neuroblastoma+SH-SY5Y+cells.&rft.au=Conn%2C+K+J%3BUllman%2C+M+D%3BEisenhauer%2C+P+B%3BFine%2C+R+E%3BWells%2C+J+M&rft.aulast=Conn&rft.aufirst=K&rft.date=2001-06-29&rft.volume=306&rft.issue=3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-02 N1 - Date created - 2001-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - fMRI study of face emotion processing: An analysis of functional connectivity in healthy and anxious adults AN - 39348024; 3599506 AU - Goldin, P AU - Brown, G AU - Zorilla, LE AU - Stein, M Y1 - 2001/06/22/ PY - 2001 DA - 2001 Jun 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39348024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=fMRI+study+of+face+emotion+processing%3A+An+analysis+of+functional+connectivity+in+healthy+and+anxious+adults&rft.au=Goldin%2C+P%3BBrown%2C+G%3BZorilla%2C+LE%3BStein%2C+M&rft.aulast=Goldin&rft.aufirst=P&rft.date=2001-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Cognitive Nueroscience Society, 6162 Moore Hall, Dartmouth College, Hanover, NH 03755, USA; phone: 603-646-1189; email: cns@dartmouth.edu; URL: www.dartmouth.edu/~cns. Poster Paper No. 56A N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical diagnosis, outbreak investigation, and surveillance of odor and irritancy problems in the workplace: Tools, predictive value, and decision logic AN - 39337532; 3606186 AU - Hodgson, MJ Y1 - 2001/06/22/ PY - 2001 DA - 2001 Jun 22 KW - CPI, Conference Papers Index KW - U 4300:Environmental Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39337532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Clinical+diagnosis%2C+outbreak+investigation%2C+and+surveillance+of+odor+and+irritancy+problems+in+the+workplace%3A+Tools%2C+predictive+value%2C+and+decision+logic&rft.au=Hodgson%2C+MJ&rft.aulast=Hodgson&rft.aufirst=MJ&rft.date=2001-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; URL: www.toxicology.org. Paper No. #649 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Colonocyte Basolateral Membranes Contain Escherichia coli Heat-Stable Enterotoxin Receptors AN - 18183855; 5131502 AB - Heat-stable enterotoxin (ST sub(a)) elaborated by E. coli is a major cause of diarrhea. The transmembrane protein guanylyl cyclase C (GC-C) is the acknowledged receptor for ST sub(a) and for the mammalian peptides guanylin and uroguanylin. Binding to GC-C results in generation of cGMP, activation of type II cGMP-dependent protein kinase, phosphorylation of CFTR and increased chloride and bicarbonate secretion. We had previously shown that ST sub(a) receptors (GC-C) are found on the brush border membranes of small intestinal enterocytes and of colonocytes. However, since it has subsequently been shown that the endogenous ligands for these receptors, guanylin and uroguanylin, circulate in blood, we proposed the existence of ST sub(a) binding sites on the basolateral membranes (BLM) of colonocytes. Specific binding of super(125)I-ST sub(a) to rat colonocyte BLM was seen. The kinetics of binding to the BLM were similar to binding to BBM. The nature of the BLM receptor is unknown. This suggests that circulating guanylin and uroguanylin, analogues of ST sub(a), may also function via the basolateral surface. Copyright 2001 Academic Press. JF - Biochemical and Biophysical Research Communications AU - Albano, F AU - Brasitus, T AU - Mann, E A AU - Guarino, A AU - Giannella, R A AD - Division of Digestive Diseases, University of Cincinnati, Veterans Administration Medical Center, Cincinnati, Ohio, ralph.giannella@uc.edu Y1 - 2001/06/08/ PY - 2001 DA - 2001 Jun 08 SP - 331 EP - 334 PB - Academic Press VL - 284 IS - 2 SN - 0006-291X, 0006-291X KW - binding KW - colonocytes KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Diarrhea KW - Gastrointestinal tract diseases KW - Heat tolerance KW - Cell membranes KW - Escherichia coli KW - Enterotoxins KW - X 24171:Microbial KW - J 02823:In vitro and in vivo effects KW - J 02846:Gastrointestinal tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18183855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Colonocyte+Basolateral+Membranes+Contain+Escherichia+coli+Heat-Stable+Enterotoxin+Receptors&rft.au=Albano%2C+F%3BBrasitus%2C+T%3BMann%2C+E+A%3BGuarino%2C+A%3BGiannella%2C+R+A&rft.aulast=Albano&rft.aufirst=F&rft.date=2001-06-08&rft.volume=284&rft.issue=2&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1006%2Fbbrc.2001.4973 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Enterotoxins; Heat tolerance; Diarrhea; Gastrointestinal tract diseases; Cell membranes DO - http://dx.doi.org/10.1006/bbrc.2001.4973 ER - TY - JOUR T1 - Allergic fungal rhinosinusitis: current theories and management strategies. AN - 85347591; pmid-11404613 AB - The combination of nasal polyposis, crust formation, and sinus cultures yielding Aspergillus was first noted in 1976 by Safirstein,1 who observed the clinical similarity that this constellation of findings shared with allergic bronchopulmonary Aspergillosis (ABPA). Eventually this disease came to be known as allergic fungal rhinosinusitis (AFS). As clinical evidence of AFS accumulated, controversy regarding its etiology, pathogenesis, natural history, and appropriate treatment naturally emerged. Despite past and current efforts, many of these controversies remain incompletely resolved, but continuing clinical study has illuminated some aspects of the disease and has led to an improved understanding of AFS and its treatment. Fungi associated with the development of AFS are ubiquitous and predominantly of the dematiaceous family. The eosinophilic host response to the presence of these fungi within the nose and paranasal sinuses gives rise to those clinical manifestations of the disease (nasal polyps, expansile mucocele formation, allergic fungal mucin, etc.). Exposure alone to these fungi, however, appears to be insufficient to initiate the disease. At the present time it is likely that initiation of the inflammatory cascade leading to AFS is a multifactorial event, requiring the simultaneous occurrence of such things as IgE-mediated sensitivity (atopy), specific T-cell HLA receptor expression, exposure to specific fungi, and aberration of local mucosal defense mechanisms. A variety of treatment plans for AFS have emerged, but the potential for recidivism remains well recognized, ranging from 10% to nearly 100%, suggesting the need for continued study of this disease and fueling present controversy. This article is intended to review current data and theories regarding the pathophysiology of AFS, as well as the role of various surgical and nonsurgical forms of therapy. JF - The Laryngoscope AU - Marple, B F AD - Department of Otolaryngology, Dallas Veterans Administration Hospital and Parkland Memorial Hospital, Dallas, Texas, USA. Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 1006 EP - 1019 VL - 111 IS - 6 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - *Aspergillosis, Allergic Bronchopulmonary: diagnosis KW - Aspergillosis, Allergic Bronchopulmonary: therapy KW - Humans KW - Recurrence KW - *Rhinitis: diagnosis KW - Rhinitis: therapy KW - *Sinusitis: diagnosis KW - Sinusitis: therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85347591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Allergic+fungal+rhinosinusitis%3A+current+theories+and+management+strategies.&rft.au=Marple%2C+B+F&rft.aulast=Marple&rft.aufirst=B&rft.date=2001-06-01&rft.volume=111&rft.issue=6&rft.spage=1006&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Correlates of expressed and received violence across relationship types among men and women substance abusers. AN - 70944248; 11419230 AB - This study examined expressed and received violence among men and women in substance abuse treatment. Rates of past-year partner violence (PV) did not differ by gender, although men reported markedly higher rates of nonpartner violence (NPV). Compared with PV, NPV was associated with more demographic and background factors (e.g., childhood aggression and conduct problems, family history of violence). The most consistent correlates of violence across relationship types were age, minority status, drug-related consequences, psychiatric distress, and frequency of childhood aggression. Only a few gender-specific correlates were identified; most notably, witnessing father-to-mother violence was related to received PV only for women. Identification of correlates of expressed and received violence in partner and nonpartner relationships is essential for the assessment and treatment of individuals in substance abuse treatment settings. JF - Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors AU - Chermack, S T AU - Walton, M A AU - Fuller, B E AU - Blow, F C AD - Psychiatry Service, John D. Dingell Veterans Affairs Medical Center, 4646 John R. Street, Detroit, Michigan 48201, USA. stephen.chermack@med.va.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 140 EP - 151 VL - 15 IS - 2 SN - 0893-164X, 0893-164X KW - Index Medicus KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Male KW - Female KW - Stress, Psychological -- psychology KW - Interpersonal Relations KW - Affect KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Violence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70944248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+addictive+behaviors+%3A+journal+of+the+Society+of+Psychologists+in+Addictive+Behaviors&rft.atitle=Correlates+of+expressed+and+received+violence+across+relationship+types+among+men+and+women+substance+abusers.&rft.au=Chermack%2C+S+T%3BWalton%2C+M+A%3BFuller%2C+B+E%3BBlow%2C+F+C&rft.aulast=Chermack&rft.aufirst=S&rft.date=2001-06-01&rft.volume=15&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Psychology+of+addictive+behaviors+%3A+journal+of+the+Society+of+Psychologists+in+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-09 N1 - Date created - 2001-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rheumatologists' attitudes toward routine screening for hydroxychloroquine retinopathy. AN - 70927543; 11409112 AB - To examine rheumatologists' attitudes toward routine ophthalmologic screening for hydroxychloroquine (HCQ) retinopathy and to estimate the acceptability of hypothetical guidelines discouraging this practice. We E-mailed a random sample of 300 US rheumatologists listed in the American College of Rheumatology (ACR) Directory who treat adults. We asked about current screening practice, reasons for screening, and the effect of hypothetical guidelines discouraging routine screening on future practice. Associations between adherence to guidelines and clinical variables were evaluated using multiple logistic regression. Of 56% who responded, almost all (94%) currently screen their patients at least once per year. Seventy-five percent stated that they would continue to screen because they are unwilling to accept any risk of visual loss among their patients; 74% would continue to screen because of legal liability; and 56% felt their patients would insist on being screened regardless of their physician's opinion. Forty-four percent stated that they would continue to screen regularly, even if the ACR published guidelines discouraging routine screening. Rheumatologists unwilling to accept any risk of retinopathy were less likely to follow guidelines discouraging screening (46 vs 77%, adjusted OR 0.2, 95% CI 0.1-0.6). Patient insistence and fear of legal liability were not significantly associated with predicted adherence to guidelines. Our survey indicates that the majority of rheumatologists currently routinely screen their patients for HCQ retinopathy, and that many would not follow ACR guidelines discouraging this practice, at least in part because they are unwilling to accept any risk of visual damage. JF - The Journal of rheumatology AU - Fraenkel, L AU - Felson, D T AD - Yale University, Department of Internal Medicine, Section of Rheumatology, PO Box 208031, 333 Cedar Street, New Haven, CT 06520-8031, USA. liana.fraenkel@med.va.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 1218 EP - 1221 VL - 28 IS - 6 SN - 0315-162X, 0315-162X KW - Antirheumatic Agents KW - 0 KW - Hydroxychloroquine KW - 4QWG6N8QKH KW - Index Medicus KW - United States KW - Vision, Low -- chemically induced KW - Humans KW - Professional Practice -- legislation & jurisprudence KW - Liability, Legal KW - Professional Practice -- statistics & numerical data KW - Mass Screening -- psychology KW - Mass Screening -- legislation & jurisprudence KW - Practice Guidelines as Topic KW - Risk Management KW - Mass Screening -- standards KW - Professional Practice -- standards KW - Female KW - Male KW - Rheumatology -- standards KW - Rheumatology -- statistics & numerical data KW - Attitude of Health Personnel KW - Antirheumatic Agents -- toxicity KW - Hydroxychloroquine -- toxicity KW - Retinal Diseases -- chemically induced KW - Rheumatology -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70927543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+rheumatology&rft.atitle=Rheumatologists%27+attitudes+toward+routine+screening+for+hydroxychloroquine+retinopathy.&rft.au=Fraenkel%2C+L%3BFelson%2C+D+T&rft.aulast=Fraenkel&rft.aufirst=L&rft.date=2001-06-01&rft.volume=28&rft.issue=6&rft.spage=1218&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+rheumatology&rft.issn=0315162X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of cidofovir in progressive multifocal leukoencephalopathy. AN - 70924838; 11408993 AB - Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating illness caused by the JC virus, a polyomavirus that occurs in 4-5% of HIV-positive patients. Mortality is high, and no useful therapy has been identified. Highly active antiretroviral therapy (HAART) has been reported to be effective in halting progression of the disease in some, but not all, patients. Cidofovir has been shown to be active against polyomaviruses. To review data on the use of cidofovir to treat PML. English-language case reports and clinical studies were located through a literature search (MEDLINE and AIDSLINE, 1995-July 2000). Relevant case reports and studies describing the use of cidofovir for PML were reviewed. Most case reports describing the use of cidofovir have shown that the drug is effective in the treatment of PML. Some patients were also receiving HAART concurrently; therefore, it is not clear which treatment modality had a greater impact on PML. However, cidofovir may be effective in patients whose disease has progressed despite HAART or who are-unable to tolerate these regimens. A pilot study of cidofovir for treating PML has completed enrollment, but preliminary results showed no benefit. Cidofovir may be the most reasonable treatment option for PML in HIV-infected individuals who fail to improve with HAART or who are unable to tolerate these regimens. Patients who receive cidofovir should be monitored for renal and ocular toxicity. JF - The Annals of pharmacotherapy AU - Segarra-Newnham, M AU - Vodolo, K M AD - Veterans Affairs Medical Center, West Palm Beach, FL, USA. marisel.segarra-newnham@med.va.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 741 EP - 744 VL - 35 IS - 6 SN - 1060-0280, 1060-0280 KW - Antiviral Agents KW - 0 KW - Organophosphonates KW - Organophosphorus Compounds KW - Cytosine KW - 8J337D1HZY KW - cidofovir KW - JIL713Q00N KW - Index Medicus KW - Humans KW - Treatment Outcome KW - Male KW - Female KW - Antiviral Agents -- therapeutic use KW - Organophosphorus Compounds -- therapeutic use KW - Cytosine -- therapeutic use KW - Leukoencephalopathy, Progressive Multifocal -- drug therapy KW - Cytosine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70924838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Use+of+cidofovir+in+progressive+multifocal+leukoencephalopathy.&rft.au=Segarra-Newnham%2C+M%3BVodolo%2C+K+M&rft.aulast=Segarra-Newnham&rft.aufirst=M&rft.date=2001-06-01&rft.volume=35&rft.issue=6&rft.spage=741&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-18 N1 - Date created - 2001-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuroleptic malignant syndrome during a change from haloperidol to risperidone. AN - 70918745; 11408988 AB - To report a case of neuroleptic malignant syndrome (NMS) in a patient whose therapy was being switched from haloperidol to risperidone. A 57-year-old African-American man, treated for schizophrenia with haloperidol for several years, developed NMS within 48 hours of the addition of low doses of risperidone and mirtazapine to his regimen. Symptoms, which included fever, generalized rigidity, and altered mental status, resolved after discontinuation of psychotropics, supportive management, and several weeks of treatment with bromocriptine and dantrolene. He was subsequently treated with olanzapine without adverse effects. Several cases of NMS have been reported with risperidone, but none under these circumstances. NMS most likely occurred in this patient as a result of the additive dopamine 2 receptor blocking of haloperidol and risperidone. Sympathetic hyperactivity secondary to mirtazapine may also have been a contributing factor. If NMS may be induced by the simultaneous use of older, high-potency antipsychotics and newer, atypical antipsychotics such as risperidone, switching patients from older to newer antipsychotics may at times be difficult, since completely stopping one antipsychotic before starting the second may place patients at risk for psychotic relapse. Clinicians should closely monitor patients receiving both haloperidol and risperidone or combinations of similar medications. JF - The Annals of pharmacotherapy AU - Reeves, R R AU - Mack, J E AU - Torres, R A AD - GV (Sonny) Montgomery Veterans Administration Medical Center, USA. roy.reeves2@med.va.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 698 EP - 701 VL - 35 IS - 6 SN - 1060-0280, 1060-0280 KW - Antipsychotic Agents KW - 0 KW - Haloperidol KW - J6292F8L3D KW - Risperidone KW - L6UH7ZF8HC KW - Index Medicus KW - Humans KW - Schizophrenia -- drug therapy KW - Middle Aged KW - Male KW - Haloperidol -- adverse effects KW - Neuroleptic Malignant Syndrome -- etiology KW - Haloperidol -- therapeutic use KW - Antipsychotic Agents -- therapeutic use KW - Risperidone -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Risperidone -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70918745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Neuroleptic+malignant+syndrome+during+a+change+from+haloperidol+to+risperidone.&rft.au=Reeves%2C+R+R%3BMack%2C+J+E%3BTorres%2C+R+A&rft.aulast=Reeves&rft.aufirst=R&rft.date=2001-06-01&rft.volume=35&rft.issue=6&rft.spage=698&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-18 N1 - Date created - 2001-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Countervailing influence of tumor necrosis factor-alpha and nitric oxide in endotoxemia. AN - 70861978; 11373343 AB - Tumor necrosis factor-alpha (TNF-alpha), a crucial mediator in sepsis, elicits multiple biologic effects, including intravascular thrombosis and circulatory shock. TNF-alpha exerts its biologic effects through two distinct cell surface receptors, TNF-R1 and TNF-R2. The pathophysiologic interaction between TNF-alpha and nitric oxide (NO) in glomerular thrombosis caused by endotoxemia in rats and wild-type mice (C57BL6) as well as in knockout mice that are deficient in TNF-R1 (R1 -/-), TNF-R2 (R2 -/-), or both receptors (R1R2 -/-) was studied. Administration of lipopolysaccharide (LPS; Escherichia coli endotoxin) resulted in increased NO and TNF-alpha production but failed to induce glomerular thrombosis. Concomitant administration of LPS + NG-nitro-L-arginine methyl ester (L-NAME; an NO synthesis inhibitor) resulted in glomerular thrombosis in rats and in wild-type mice. Intraperitoneal administration of pentoxifylline before LPS inhibited TNF-alpha synthesis and prevented glomerular thrombosis in rats given LPS + L-NAME. In contrast to the results observed in rats and wild-type mice, administration of LPS + L-NAME did not result in glomerular thrombosis in knockout mice with either single or double TNF-alpha receptor deletion. Thus, during endotoxemia, (1) TNF-alpha fosters glomerular thrombosis if there is deficiency of NO synthesis and (2) both TNF-alpha receptors are necessary for TNF-alpha's prothrombogenic action. Clinically, these novel studies suggest that in gram-negative endotoxemia, inhibition of NO synthesis and selective blockade of TNF-alpha receptors may provide unique therapeutic approaches for mitigation of glomerular thrombosis and restitution of vascular tone. JF - Journal of the American Society of Nephrology : JASN AU - Jaimes, E A AU - del Castillo, D AU - Rutherford, M S AU - Raij, L AD - Nephrology and Hypertension Section, Veterans Administration Medical Center, Minneapolis, Minnesota 55417, USA. Jaime002@tc.umn.edu. Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 1204 EP - 1210 VL - 12 IS - 6 SN - 1046-6673, 1046-6673 KW - Enzyme Inhibitors KW - 0 KW - Lipopolysaccharides KW - Tumor Necrosis Factor-alpha KW - Nitric Oxide KW - 31C4KY9ESH KW - Pentoxifylline KW - SD6QCT3TSU KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Index Medicus KW - Animals KW - Analysis of Variance KW - NG-Nitroarginine Methyl Ester -- pharmacology KW - Pentoxifylline -- pharmacology KW - Mice KW - Mice, Knockout KW - Rats KW - Rats, Sprague-Dawley KW - Escherichia coli KW - Enzyme Inhibitors -- pharmacology KW - Enzyme-Linked Immunosorbent Assay KW - Lipopolysaccharides -- toxicity KW - Male KW - Thrombosis -- etiology KW - Nitric Oxide -- metabolism KW - Tumor Necrosis Factor-alpha -- metabolism KW - Kidney Glomerulus -- metabolism KW - Endotoxemia -- enzymology KW - Endotoxemia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70861978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=Countervailing+influence+of+tumor+necrosis+factor-alpha+and+nitric+oxide+in+endotoxemia.&rft.au=Jaimes%2C+E+A%3Bdel+Castillo%2C+D%3BRutherford%2C+M+S%3BRaij%2C+L&rft.aulast=Jaimes&rft.aufirst=E&rft.date=2001-06-01&rft.volume=12&rft.issue=6&rft.spage=1204&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-02 N1 - Date created - 2001-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hypersensitivity pneumonitis in a metal-working environment AN - 18086317; 5172819 AB - Background: An outbreak of lung disease among workers in a metal-working plant included 16 biopsy-confirmed cases of hypersensitivity pneumonitis and additional patients with asthma, bronchiolitis and emphysema, usual interstitial pneumonitis, and sarcoidosis. Study design: Clinical examination of patients; cross-sectional questionnaire survey of the outbreak plant and two control plant areas, one with and one without MWF exposures, in a separate facility; industrial hygiene survey with laboratory characterization of microbial flora; and immunological investigation. Methods: Patients with suspected hypersensitivity pneumonitis underwent a clinical examination including detailed lung function, imaging, and tissue studies. A plant walk-through identified metal-working processes, microbial aerosols, and work practices. Microbial characteristics of the three microbial aerosol-producing processes were characterized. Antibodies to those agents were determined in patient sera. A questionnaire survey was conducted in the case plant and in two areas of a control plant, one with and one without metal-working fluids exposure. Results: Thirty-nine (79.6%) patients described symptoms consistent with work-related lung disease, eight received other diagnoses, and two did not complete their examinations. Sixteen patients had hypersensitivity pneumonitis confirmed on biopsy. Mean decrements in lung forced expiratory volume in 1 s and force vital capacity from before to after work were similar in the 16 biopsy-confirmed cases of hypersensitivity pneumonitis ( - 6.3%; - 7.2%) and the 19 symptomatic patients without biopsies ( - 11.2%, - 10.1%). Symptoms were more common in the case plant than in a non-MWF control plant area. Three sources of water-based aerosols were identified that grew similar microbial flora. Although machining increased airborne bacterial levels, the increase was not related to the concentration of viable bacteria in the sumps. Antibody testing did not identify a specific single organisms. Endotoxin levels were similar in case and MWF control plant. Conclusions: Lung disease in environments with water-based aerosols may be more common than usually recognized. Patients with HP often present with only subtle abnormalities and may be missed if multiple clinical abnormalities are required to document disease. JF - American Journal of Industrial Medicine AU - Hodgson, MJ AU - Bracker, A AU - Yang, C AU - Storey, E AU - Jarvis, B J AU - Milton, D AU - Lummus, Z AU - Bernstein, D AU - Cole, S AD - Occupational Health Programs (136), Veterans Health Administration, 810 Vermont Avenue, NW, Washington, DC 20420, USA, muh7@mail.va.gov Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 616 EP - 628 VL - 39 IS - 6 SN - 0271-3586, 0271-3586 KW - man KW - hypersensitivity KW - pneumonitis KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Metals KW - Aerosols KW - Lung diseases KW - Respiratory diseases KW - Hypersensitivity KW - Pneumonitis KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - X 24162:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18086317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Hypersensitivity+pneumonitis+in+a+metal-working+environment&rft.au=Hodgson%2C+MJ%3BBracker%2C+A%3BYang%2C+C%3BStorey%2C+E%3BJarvis%2C+B+J%3BMilton%2C+D%3BLummus%2C+Z%3BBernstein%2C+D%3BCole%2C+S&rft.aulast=Hodgson&rft.aufirst=MJ&rft.date=2001-06-01&rft.volume=39&rft.issue=6&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Aerosols; Metals; Occupational exposure; Respiratory diseases; Pneumonitis; Hypersensitivity; Lung diseases ER - TY - JOUR T1 - Fast neutron radiotherapy for soft tissue and cartilaginous sarcomas at high risk for local recurrence AN - 17890642; 5133844 AB - The practice policy at the University of Washington has been to employ fast neutron radiotherapy for soft tissue sarcoma lesions with prognostic features predictive for poor local control. These include gross residual disease/inoperable disease, recurrent disease, and contaminated surgical margins. Cartilaginous sarcomas have also been included in this high-risk group. This report updates and expands our previously described experience with this approach. Eighty-nine soft tissue sarcoma lesions in 72 patients were treated with neutron radiotherapy in our department between 1984 and 1996. Six patients, each with solitary lesions, were excluded from analysis due to lack of follow-up. Seventy-three percent were treated with fast neutron radiation alone, the rest with a combination of neutrons and photons. Median neutron dose was 18.3 nGy (range 4.8-22). Forty-two patients with solitary lesions were treated with curative intent. Thirty-one patients (including 7 previously treated with neutrons) with 41 lesions were treated with the goal of local palliation. Tumors were predominantly located in the extremity and torso. Thirty of 35 (85%) of curative group patients treated postoperatively had close or positive surgical margins. Thirty-four (82%) lesions treated for palliation were unresectable. Thirty-five patients (53%) were treated at the time of recurrence. Median tumor size at initial presentation was 8.0 cm (range 0.6-29), median treated gross disease size was 5.0 cm (range 1-22), and 46/69 evaluable lesions (67%) were judged to be of intermediate to high histologic grade. Fourteen patients (21%) had chondrosarcomas. Median follow-up was 6 months (range 2-47) and 38 months (range 2-175) for the palliative and curative groups, respectively. Kaplan-Meier estimates were obtained for probability of local relapse-free survival (68%), distant disease-free survival (59%), cause-specific survival (68%), and overall survival (66%) at 4 years for the curatively treated group. For the palliatively treated group, estimated local relapse-free survival at 1 year was 62%. Log-rank analysis of the curative group revealed recurrent disease to be the only risk factor predictive for significantly worse local and distant disease-free survival. Intermediate-/high-grade histology was predictive for inferior overall survival. Effective clinical response was documented for 21/27 (78%) lesions treated palliatively. Ten patients (15%) experienced serious chronic radiation-related complications. All of these patients had clinical situations requiring delivery of high neutron doses and/or large radiotherapy fields. Fast neutron radiotherapy is locally effective for soft tissue and cartilaginous sarcomas having well-recognized high-risk features. Results in the palliative setting appear to be particularly encouraging, with neutrons frequently providing significant symptomatic response for gross disease, with minimal serious chronic sequelae. Fast neutron radiotherapy should be considered in patients at high risk for local recurrence in both the curative and palliative settings. JF - International Journal of Radiation Oncology, Biology, & Physics AU - Schwartz, D L AU - Einck, J AU - Bellon, J AU - Laramore, GE AD - Department of Radiation Oncology, Seattle VA Medical Center/Puget Sound Health Care System [174], 1660 S. Columbian Way, Seattle, WA 98108, USA, david.schwartz2@med.va.gov Y1 - 2001/06/01/ PY - 2001 DA - 2001 Jun 01 SP - 449 EP - 456 VL - 50 IS - 2 SN - 0360-3016, 0360-3016 KW - man KW - cancer patients KW - soft tissues KW - fast neutron radiotherapy KW - Calcium & Calcified Tissue Abstracts; Toxicology Abstracts KW - Neutrons KW - Cartilage diseases KW - Cartilage KW - Sarcoma KW - Radiotherapy KW - Soft tissues KW - X 24210:Radiation & radioactive materials KW - T 20018:Cartilage and cartilage diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17890642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.atitle=Fast+neutron+radiotherapy+for+soft+tissue+and+cartilaginous+sarcomas+at+high+risk+for+local+recurrence&rft.au=Schwartz%2C+D+L%3BEinck%2C+J%3BBellon%2C+J%3BLaramore%2C+GE&rft.aulast=Schwartz&rft.aufirst=D&rft.date=2001-06-01&rft.volume=50&rft.issue=2&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Neutrons; Radiotherapy; Cartilage diseases; Soft tissues; Sarcoma; Cartilage ER - TY - JOUR T1 - Effects of lexical factors on word recognition among normal-hearing and hearing-impaired listeners. AN - 85361941; pmid-11392435 AB - An investigation was conducted to examine the effects of lexical difficulty on spoken word recognition among young normal-hearing and middle-aged and older listeners with hearing loss. Two word lists, based on the lexical characteristics of word frequency and neighborhood density and frequency (Neighborhood Activation Model [NAM]), were developed: (1) lexically "easy" words with high word frequency and a low number and frequency of words phonemically similar to the target word and (2) lexically "hard" words with low word frequency and a high number and frequency of words phonemically similar to the target word. Simple and transformed up-down adaptive strategies were used to estimate performance levels at several locations on the performance-intensity functions of the words. The results verified predictions of the NAM and showed that easy words produced more favorable performance levels than hard words at an equal intelligibility. Although the slopes of the performance-intensity function for the hearing-impaired listeners were less steep than those of normal-hearing listeners, the effects of lexical difficulty on performance were similar for both groups. JF - Journal of the American Academy of Audiology AU - Dirks, D D AU - Takayana, S AU - Moshfegh, A AD - National Center for Rehabilitative Auditory Research, Veterans Administration Medical Center, Portland, OR, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 233 EP - 244 VL - 12 IS - 5 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Aged KW - Aged, 80 and over KW - Auditory Threshold: physiology KW - Female KW - *Hearing Loss, Sensorineural: diagnosis KW - Humans KW - Male KW - Middle Aged KW - Phonetics KW - Random Allocation KW - *Recognition (Psychology) KW - Severity of Illness Index KW - *Speech Perception KW - *Vocabulary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85361941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Effects+of+lexical+factors+on+word+recognition+among+normal-hearing+and+hearing-impaired+listeners.&rft.au=Dirks%2C+D+D%3BTakayana%2C+S%3BMoshfegh%2C+A&rft.aulast=Dirks&rft.aufirst=D&rft.date=2001-05-01&rft.volume=12&rft.issue=5&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - p53 protein overexpression in low grade dysplasia (LGD) in Barrett's esophagus: immunohistochemical marker predictive of progression. AN - 85350560; pmid-11374668 AB - The presence of low grade dysplasia (LGD) within Barrett's esophagus (BE) has a multitude of ramifications. Identification of markers that could risk stratify LGD would be of great clinical benefit. We aimed to prospectively evaluate the prognosis of the immunohistochemical overexpression of p53 protein in BE colocalized to LGD.Consecutive BE patients in whom LGD was found had a repeat esophagogastroduodenoscopy within 8-12 wk per an ongoing prospective study. At each esophagogastroduodenoscopy, a therapeutic scope was used in conjunction with the Seattle Biopsy Protocol. Patients were observed until development of multifocal high grade dysplasia (mHGD), presence of an HGD dysplasia-associated lesion or mass (DALM) lesion, or frank adenocarcinoma. p53 protein overexpression was determined by computerized immunoquantitation using image analysis software on step serial-sectioned specimens of BE segment(s) harboring LGD. Kaplan-Meier survival curves were made on the ability of p53 staining colocalized to areas of LGD to predict progression to mHGD, HGD DALM, or cancer during prospective follow-up.Forty-eight BE patients with LGD were observed for a mean of 41.2+/-22.5 months. During this period, five of 48 patients progressed to mHGD with a focus in which intramucosal cancer could not be excluded (one), mHGD/DALM with one or more foci in which intramucosal cancer could not be excluded (two), cancer (one), or mHGD (one). Twelve had persistent LGD and 31 had regressed to no dysplasia. p53 staining was positive and colocalized to areas of LGD in 4/31 of patients that regressed, 3/12 that persisted, and 3/5 that progressed. Kaplan-Meier curves differed significantly between p53 positive and negative patients for outcome defined as progression of LGD.p53 colocalization with LGD at index LGD diagnosis is a risk factor for progression of LGD. This can potentially be used to risk stratify BE LGD patients in terms of surveillance intervals or enrollment into secondary prevention studies. JF - The American journal of gastroenterology AU - Weston, A P AU - Banerjee, S K AU - Sharma, P AU - Tran, T M AU - Richards, R AU - Cherian, R AD - Cancer Research Unit, Research Division, Veterans Administration Medical Center, Kansas City, Missouri 64128-2226, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 1355 EP - 1362 VL - 96 IS - 5 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - *Barrett Esophagus: metabolism KW - *Barrett Esophagus: pathology KW - Biological Markers KW - Disease Progression KW - Esophageal Neoplasms: metabolism KW - Esophageal Neoplasms: pathology KW - Female KW - Humans KW - Immunohistochemistry KW - Male KW - Middle Aged KW - Prognosis KW - Prospective Studies KW - Risk Factors KW - Survival Analysis KW - *Tumor Suppressor Protein p53: metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85350560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=p53+protein+overexpression+in+low+grade+dysplasia+%28LGD%29+in+Barrett%27s+esophagus%3A+immunohistochemical+marker+predictive+of+progression.&rft.au=Weston%2C+A+P%3BBanerjee%2C+S+K%3BSharma%2C+P%3BTran%2C+T+M%3BRichards%2C+R%3BCherian%2C+R&rft.aulast=Weston&rft.aufirst=A&rft.date=2001-05-01&rft.volume=96&rft.issue=5&rft.spage=1355&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: Am J Gastroenterol. 2001 May;96(5):1321-3[11374661] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Transforming growth factor and neutralizing antibodies in subglottic stenosis. AN - 85350404; pmid-11372920 AB - Transforming growth factor beta 1 (TGF-beta1), which is implicated in the pathogenesis of fibrotic diseases such as interstitial fibrosis, may be associated with subglottic stenosis. To study this hypothesis, we measured TGF-beta1 expression sequentially in 28 rats after posterior cricoid injury, using both standard immunohistochemistry and reverse transcriptase-polymerase chain reaction. In addition, an osmotic pump infused TGF-beta1 in 18 rats, normal saline solution in 9 rats, and neutralizing antibodies in 9 rats. Specimens were stained for fibronectin and procollagen at 1, 7, and 21 days and underwent optical density analysis. In the injured airway, TGF-beta1 expression peaked at 1 day and returned to baseline by 21 days. The TGF-beta1 infusion led to an increase in the expression of extracellular matrix proteins relative to controls. In contrast, neutralizing antibodies led to a decrease in extracellular matrix protein expression. These findings suggest that TGF-beta1 may possibly play a role in the pathogenesis of subglottic stenosis. JF - The Annals of otology, rhinology, and laryngology AU - Dillard, D G AU - Gal, A A AU - Roman-Rodriguez, J AU - White, S AU - Jacobs, I N AD - Department of Otolaryngology, Atlanta Veterans Administration Medical Center and Emory University School of Medicine, Georgia, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 393 EP - 400 VL - 110 IS - 5 Pt 1 SN - 0003-4894, 0003-4894 KW - National Library of Medicine KW - Animals KW - Fibronectins: metabolism KW - Immunohistochemistry KW - *Laryngostenosis: drug therapy KW - *Laryngostenosis: metabolism KW - Male KW - Procollagen: metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Reverse Transcriptase Polymerase Chain Reaction KW - Transforming Growth Factor beta: immunology KW - *Transforming Growth Factor beta: metabolism KW - *Transforming Growth Factor beta: pharmacology KW - Wound Healing: drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85350404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.atitle=Transforming+growth+factor+and+neutralizing+antibodies+in+subglottic+stenosis.&rft.au=Dillard%2C+D+G%3BGal%2C+A+A%3BRoman-Rodriguez%2C+J%3BWhite%2C+S%3BJacobs%2C+I+N&rft.aulast=Dillard&rft.aufirst=D&rft.date=2001-05-01&rft.volume=110&rft.issue=5+Pt+1&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.issn=00034894&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Penicillin-binding protein 5 and expression of ampicillin resistance in Enterococcus faecium. AN - 77057895; 11302814 AB - We report a structural and transcriptional analysis of the pbp5 region of Enterococcus faecium C68. pbp5 exists within a larger operon that includes upstream open reading frames (ORFs) corresponding to previously reported psr (penicillin-binding protein synthesis repressor) and ftsW (whose product is a transmembrane protein that interacts with PBP3 in Escherichia coli septum formation) genes. Hybridization of mRNA from C68, CV133, and four ampicillin-resistant CV133 mutants revealed four distinct transcripts from this region, consisting of (i) E. faecium ftsW (ftsW(Efm)) alone; (ii) psr and pbp5; (iii) pbp5 alone; and (iv) ftsW(Efm), psr, and pbp5. Quantities of the different transcripts varied between strains and did not always correlate with quantities of PBP5 or levels of ampicillin resistance. Since the psr of C68 is presumably nonfunctional due to an insertion of an extra nucleotide in the codon for the 44th amino acid, the region extending from the ftsW(Efm) promoter through the pbp5 gene of C68 was cloned in E. coli to facilitate mutagenesis. The psr ORF was regenerated using site-directed mutagenesis and introduced into E. faecium D344-SRF on conjugative shuttle vector pTCV-lac (pCWR558 [psr ORF interrupted]; pCWR583 [psr ORF intact]). Ampicillin MICs for both D344-SRF(pCWR558) and D344-SRF(pCWR583) were 64 microg/ml. Quantities of pbp5 transcript and protein were similar in strains containing either construct regardless of whether they were grown in the presence or absence of ampicillin, arguing against a role for PSR as a repressor of pbp5 transcription. However, quantities of psr transcript were increased in D344-SRF(pCWR583) compared to D344-SRF(pCWR558), especially after growth in ampicillin; suggesting that PSR acts in some manner to activate its own transcription. JF - Antimicrobial agents and chemotherapy AU - Rice, L B AU - Carias, L L AU - Hutton-Thomas, R AU - Sifaoui, F AU - Gutmann, L AU - Rudin, S D AD - Medical and Research Services, VA Medical Center, Cleveland, Ohio 44106, USA. louis.rice@med.va.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 1480 EP - 1486 VL - 45 IS - 5 SN - 0066-4804, 0066-4804 KW - Bacterial Proteins KW - 0 KW - Carrier Proteins KW - DNA, Bacterial KW - Membrane Proteins KW - Penicillin-Binding Proteins KW - Psr protein, Enterococcus hirae KW - Repressor Proteins KW - FtsW protein, Bacteria KW - 125724-13-2 KW - Peptidyl Transferases KW - EC 2.3.2.12 KW - Hexosyltransferases KW - EC 2.4.1.- KW - Muramoylpentapeptide Carboxypeptidase KW - EC 3.4.17.8 KW - Index Medicus KW - Base Sequence KW - Bacterial Proteins -- genetics KW - Blotting, Northern KW - Genome, Bacterial KW - Molecular Sequence Data KW - Gene Expression KW - Transcription, Genetic KW - DNA, Bacterial -- analysis KW - Repressor Proteins -- genetics KW - Ampicillin Resistance -- genetics KW - Carrier Proteins -- metabolism KW - Enterococcus faecium -- metabolism KW - Enterococcus faecium -- genetics KW - Carrier Proteins -- genetics KW - Muramoylpentapeptide Carboxypeptidase -- genetics KW - Muramoylpentapeptide Carboxypeptidase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77057895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Penicillin-binding+protein+5+and+expression+of+ampicillin+resistance+in+Enterococcus+faecium.&rft.au=Rice%2C+L+B%3BCarias%2C+L+L%3BHutton-Thomas%2C+R%3BSifaoui%2C+F%3BGutmann%2C+L%3BRudin%2C+S+D&rft.aulast=Rice&rft.aufirst=L&rft.date=2001-05-01&rft.volume=45&rft.issue=5&rft.spage=1480&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-02 N1 - Date created - 2001-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4891-6 [10759563] Clin Infect Dis. 1999 Sep;29(3):573-9 [10530450] J Mol Biol. 1983 Jun 5;166(4):557-80 [6345791] J Gen Microbiol. 1983 Mar;129(3):813-22 [6409985] J Bacteriol. 1983 Sep;155(3):1343-50 [6411688] Antimicrob Agents Chemother. 1982 Aug;22(2):295-301 [6927638] J Gen Microbiol. 1985 Aug;131(8):1933-40 [3850924] Antimicrob Agents Chemother. 1985 Nov;28(5):678-83 [3853962] J Bacteriol. 1989 Oct;171(10):5523-30 [2676977] J Bacteriol. 1989 Nov;171(11):6375-8 [2509435] J Mol Biol. 1990 Oct 5;215(3):403-10 [2231712] Antimicrob Agents Chemother. 1992 Jul;36(7):1367-73 [1510429] J Bacteriol. 1993 Apr;175(7):2046-51 [8458847] Antimicrob Agents Chemother. 1994 Sep;38(9):1980-3 [7811006] J Bacteriol. 1996 Aug;178(16):4948-57 [8759860] J Bacteriol. 1996 Sep;178(17):5272-8 [8752348] Antimicrob Agents Chemother. 1996 Feb;40(2):354-7 [8834879] J Bacteriol. 1997 Apr;179(8):2567-72 [9098054] Mol Microbiol. 1997 Jun;24(6):1263-73 [9218774] FEMS Microbiol Lett. 1997 Nov 15;156(2):193-8 [9513264] J Infect Dis. 1998 Jul;178(1):159-63 [9652435] Biotechniques. 1998 Jul;25(1):72-4, 76, 78 [9668979] J Bacteriol. 1998 Sep;180(17):4426-34 [9721279] Clin Infect Dis. 1999 Aug;29(2):259-63 [10476722] DNA Seq. 1998;9(3):149-61 [10520745] J Biol Chem. 2000 Jun 2;275(22):16490-6 [10748168] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanism and suppression of lysostaphin resistance in oxacillin-resistant Staphylococcus aureus. AN - 77054140; 11302806 AB - The potential for the development of resistance in oxacillin-resistant Staphylococcus aureus (ORSA) to lysostaphin, a glycylglycine endopeptidase produced by Staphylococcus simulans biovar staphylolyticus, was examined in vitro and in an in vivo model of infection. Following in vitro exposure of ORSA to subinhibitory concentrations of lysostaphin, lysostaphin-resistant mutants were idenitifed among all isolates examined. Resistance to lysostaphin was associated with a loss of resistance to beta-lactams and a change in the muropeptide interpeptide cross bridge from pentaglycine to a single glycine. Mutations in femA, the gene required for incorporation of the second and third glycines into the cross bridge, were found following PCR amplification and nucleotide sequence analysis. Complementation of lysostaphin-resistant mutants with pBBB31, which encodes femA, restored the phenotype of oxacillin resistance and lysostaphin susceptibility. Addition of beta-lactam antibiotics to lysostaphin in vitro prevented the development of lysostaphin-resistant mutants. In the rabbit model of experimental endocarditis, administration of a low dose of lysostaphin for 3 days led predictably to the appearance of lysostaphin-resistant ORSA mutants in vegetations. Coadministration of nafcillin with lysostaphin prevented the emergence of lysostaphin-resistant mutants and led to a mean reduction in aortic valve vegetation counts of 7.5 log(10) CFU/g compared to those for untreated controls and eliminated the isolation of lysostaphin-resistant mutants from aortic valve vegetations. Treatment with nafcillin and lysostaphin given alone led to mean reductions of 1.35 and 1.65 log(10) CFU/g respectively. In ORSA, resistance to lysostaphin was associated with mutations in femA, but resistance could be suppressed by the coadministration of beta-lactam antibiotics. JF - Antimicrobial agents and chemotherapy AU - Climo, M W AU - Ehlert, K AU - Archer, G L AD - Department of Medicine, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USA. Michael.Climo@med.va.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 1431 EP - 1437 VL - 45 IS - 5 SN - 0066-4804, 0066-4804 KW - Anti-Bacterial Agents KW - 0 KW - Bacterial Proteins KW - FemA protein, Bacteria KW - Penicillins KW - Peptides KW - Lysostaphin KW - EC 3.4.24.75 KW - Oxacillin KW - UH95VD7V76 KW - Index Medicus KW - Penicillins -- pharmacology KW - Drug Resistance, Microbial -- physiology KW - Drug Interactions KW - Bacterial Proteins -- genetics KW - Humans KW - Drug Resistance, Microbial -- genetics KW - Mutation KW - Microbial Sensitivity Tests KW - Oxacillin -- pharmacology KW - Staphylococcus aureus -- genetics KW - Drug Therapy, Combination -- pharmacology KW - Anti-Bacterial Agents -- pharmacology KW - Lysostaphin -- pharmacology KW - Staphylococcus aureus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77054140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Mechanism+and+suppression+of+lysostaphin+resistance+in+oxacillin-resistant+Staphylococcus+aureus.&rft.au=Climo%2C+M+W%3BEhlert%2C+K%3BArcher%2C+G+L&rft.aulast=Climo&rft.aufirst=M&rft.date=2001-05-01&rft.volume=45&rft.issue=5&rft.spage=1431&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-02 N1 - Date created - 2001-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 1974 Aug 1;291(5):239-40 [4525537] J Bacteriol. 1964 Sep;88:815-6 [14208531] J Bacteriol. 1991 Jun;173(11):3507-13 [2045371] J Bacteriol. 1993 Mar;175(6):1612-20 [8383661] J Bacteriol. 1993 May;175(9):2779-82 [8478340] J Bacteriol. 2000 May;182(9):2635-8 [10762270] J Bacteriol. 1967 Feb;93(2):520-4 [6020559] Yale J Biol Med. 1967 Feb;39(4):230-44 [4961995] Yale J Biol Med. 1967 Feb;39(4):215-29 [5182857] Antimicrob Agents Chemother (Bethesda). 1967;7:45-53 [5628090] Yale J Biol Med. 1968 Aug;41(1):62-8 [5683827] Yale J Biol Med. 1971 Oct;44(2):206-13 [5123055] Prog Drug Res. 1972;16:309-33 [4265118] J Bacteriol. 1996 Aug;178(16):4975-83 [8759863] J Bacteriol. 1997 Jan;179(1):9-16 [8981974] Microb Drug Resist. 1996 Spring;2(1):29-41 [9158720] J Antimicrob Chemother. 1997 Jul;40(1):59-66 [9249205] J Antimicrob Chemother. 1997 Jul;40(1):135-6 [9249217] FEMS Microbiol Lett. 1997 Aug 15;153(2):261-4 [9271851] J Bacteriol. 1997 Dec;179(23):7573-6 [9393725] J Clin Microbiol. 1998 Apr;36(4):1020-7 [9542929] Antimicrob Agents Chemother. 1998 Jun;42(6):1355-60 [9624475] Curr Pharm Des. 1999 Feb;5(2):45-55 [10066883] FEMS Microbiol Lett. 1999 Feb 15;171(2):97-102 [10077832] Antimicrob Agents Chemother. 1999 Jul;43(7):1747-53 [10390234] Antimicrob Agents Chemother. 1999 Jul;43(7):1754-5 [10390235] Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9351-6 [10430946] Mol Gen Genet. 1989 Oct;219(1-2):263-9 [2559314] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Feverfew extracts and the sesquiterpene lactone parthenolide inhibit intercellular adhesion molecule-1 expression in human synovial fibroblasts. AN - 70989281; 11446741 AB - Previous studies have shown that extracts of the aromatic herb feverfew (Tanacetum parthenium) and one of its bioactive components, parthenolide, have anti-inflammatory properties in vivo and in vitro. We examined both crude feverfew extracts and purified parthenolide for their ability to modulate adhesion molecule expression in human synovial fibroblasts. Pretreatment of synovial fibroblasts with either feverfew extracts or purified parthenolide could inhibit the expression of intercellular adhesion molecule-1 (ICAM-1) induced by the cytokines IL-1 (up to 95% suppression), TNF-alpha (up to 93% suppression), and, less strongly, interferon-gamma (up to 39% suppression). Inhibition of ICAM-1 was dose and time dependent; as little as a 30-min pretreatment with feverfew resulted in inhibition of ICAM-1. The decrease in ICAM-1 expression was accompanied by a decrease in T-cell adhesion to the treated fibroblasts. Other herbal extracts with reported anti-inflammatory effects were similarly tested and did not decrease ICAM-1 expression. The modulation of adhesion molecule expression may be an additional mechanism by which feverfew mediates anti-inflammatory effects. Copyright 2001 Academic Press. JF - Cellular immunology AU - Piela-Smith, T H AU - Liu, X AD - Research Service, Veterans Administration Connecticut Healthcare System, Newington, Connecticut 06111, USA. tsmith@nso2.uchc.edu Y1 - 2001/05/01/ PY - 2001 DA - 2001 May 01 SP - 89 EP - 96 VL - 209 IS - 2 SN - 0008-8749, 0008-8749 KW - Anti-Inflammatory Agents KW - 0 KW - Interleukin-1 KW - Lactones KW - Plant Extracts KW - Sesquiterpenes KW - Tumor Necrosis Factor-alpha KW - Intercellular Adhesion Molecule-1 KW - 126547-89-5 KW - parthenolide KW - 2RDB26I5ZB KW - Interferon-gamma KW - 82115-62-6 KW - Index Medicus KW - Gene Expression -- drug effects KW - Plant Extracts -- pharmacology KW - Fibroblasts -- drug effects KW - Interleukin-1 -- pharmacology KW - Humans KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Interferon-gamma -- pharmacology KW - Fibroblasts -- cytology KW - Cell Adhesion -- drug effects KW - Drug Antagonism KW - Anti-Inflammatory Agents -- pharmacology KW - Tanacetum parthenium KW - Synovial Membrane -- cytology KW - Plants, Medicinal KW - Synovial Membrane -- drug effects KW - Intercellular Adhesion Molecule-1 -- biosynthesis KW - Sesquiterpenes -- pharmacology KW - Lactones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70989281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+immunology&rft.atitle=Feverfew+extracts+and+the+sesquiterpene+lactone+parthenolide+inhibit+intercellular+adhesion+molecule-1+expression+in+human+synovial+fibroblasts.&rft.au=Piela-Smith%2C+T+H%3BLiu%2C+X&rft.aulast=Piela-Smith&rft.aufirst=T&rft.date=2001-05-01&rft.volume=209&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Cellular+immunology&rft.issn=00088749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-16 N1 - Date created - 2001-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Successful remission of late-life drinking problems: a 10-year follow-up. AN - 70941875; 11414342 AB - This study sought to determine (1) the rate and predictors of long-term remission among a sample of untreated late-life problem drinkers and (2) whether successfully remitted older problem drinkers attain levels of functioning and life contexts comparable to those of lifetime nonproblem drinkers at a 10-year follow-up. We compared 140 older baseline problem drinkers who were successful in achieving long-term remission to 184 baseline problem drinkers whose drinking problems did not remit over the course of 10 years and to 339 lifetime nonproblem drinkers, on functioning and life contexts at baseline and at 4- and 10-year follow-ups. Being female, having more recent onset of drinking problems, fewer and less severe drinking problems, friends who approved less of drinking, and drinking less and drinking less frequently at baseline predicted long-term remission. In many regards, long-term remitted problem drinkers attained levels of functioning and life context similar to those of lifetime nonproblem drinkers. However, remitted problem drinkers continued to report more incipient drinking problems, depressive symptoms, health and financial stressors, psychoactive medication use, reliance on avoidance coping strategies and less social support from friends than did lifetime nonproblem drinkers at the 10-year follow-up. About a third (30%) of an untreated sample of late-life problem drinkers succeeded in attaining stable, long-term remission. The functioning and life contexts of untreated remitted problem drinkers improved significantly over time; however, some deficits persisted at follow-up. JF - Journal of studies on alcohol AU - Schutte, K K AU - Byrne, F E AU - Brennan, P L AU - Moos, R H AD - Center for Health Care Evaluation, Department of Veterans Affairs Health Care System, & Stanford University Medical Center, Palo Alto, California 94304, USA. Kathleen.Schutte@med.va.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 322 EP - 334 VL - 62 IS - 3 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Analysis of Variance KW - Prospective Studies KW - Stress, Physiological -- psychology KW - Logistic Models KW - Adaptation, Psychological KW - Humans KW - Chi-Square Distribution KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Alcoholism -- epidemiology KW - Alcoholism -- therapy KW - Remission Induction -- methods KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70941875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Successful+remission+of+late-life+drinking+problems%3A+a+10-year+follow-up.&rft.au=Schutte%2C+K+K%3BByrne%2C+F+E%3BBrennan%2C+P+L%3BMoos%2C+R+H&rft.aulast=Schutte&rft.aufirst=K&rft.date=2001-05-01&rft.volume=62&rft.issue=3&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Destruction of peripheral C-fibers does not alter subsequent vagus nerve stimulation-induced seizure suppression in rats. AN - 70879511; 11380564 AB - Early animal studies of the therapeutic mechanisms of vagus nerve stimulation (VNS) suggested that seizure suppression requires maximal activation of small, unmyelinated vagal C fibers. However, effective therapeutic stimulation parameters appear to be subthreshold for these fibers in humans, and there are no clinical reports of the autonomic side effects that would be expected if these fibers were maximally activated. We report here that selective destruction of C fibers with capsaicin does not affect VNS-induced seizure suppression in rats. Rats were pretreated with capsaicin or vehicle in three injections over a 2-day period. A cuff electrode was later implanted on the left cervical vagus nerve. Two days after surgery, VNS was given to half of the capsaicin- and vehicle-treated rats. The remaining rats were connected to the stimulator but did not receive VNS. Thirty seconds after VNS onset, seizures were induced by pentylenetetrazol (PTZ), and seizure severity was measured. Two days later, the reciprocal VNS treatment was given, and PTZ-induced seizure severity was again measured. VNS effectively reduced seizure severity in both capsaicin- and vehicle-treated rats as compared with their non-VNS baselines. These results indicate that activation of vagal C fibers is not necessary for VNS-induced seizure suppression. JF - Epilepsia AU - Krahl, S E AU - Senanayake, S S AU - Handforth, A AD - Neurology Service, VA Greater Los Angeles Healthcare System, California 90073, USA. scott.krahl@med.va.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 586 EP - 589 VL - 42 IS - 5 SN - 0013-9580, 0013-9580 KW - Capsaicin KW - S07O44R1ZM KW - Pentylenetetrazole KW - WM5Z385K7T KW - Index Medicus KW - Severity of Illness Index KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Humans KW - Nerve Degeneration -- chemically induced KW - Animals, Newborn -- physiology KW - Capsaicin -- pharmacology KW - Seizures -- chemically induced KW - Nerve Fibers -- physiology KW - Nerve Fibers -- drug effects KW - Vagus Nerve -- physiology KW - Seizures -- diagnosis KW - Seizures -- prevention & control KW - Electric Stimulation Therapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70879511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsia&rft.atitle=Destruction+of+peripheral+C-fibers+does+not+alter+subsequent+vagus+nerve+stimulation-induced+seizure+suppression+in+rats.&rft.au=Krahl%2C+S+E%3BSenanayake%2C+S+S%3BHandforth%2C+A&rft.aulast=Krahl&rft.aufirst=S&rft.date=2001-05-01&rft.volume=42&rft.issue=5&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=Epilepsia&rft.issn=00139580&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-28 N1 - Date created - 2001-05-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oxidized LDL differentially regulates MMP-1 and TIMP-1 expression in vascular endothelial cells. AN - 70858880; 11369004 AB - We have reported recently that oxidized low-density lipoprotein (oxLDL) stimulates matrix metalloproteinase-1 (MMP-1) expression in human vascular endothelial cells. The present study was conducted to examine the effect of oxLDL on expression of Tissue inhibitor of metalloproteinase-1 (TIMP-1), an endogenous inhibitor of MMPs, in human vascular endothelial cells. Our enzyme-linked immunosorbent assay and Northern blot analysis showed that oxLDL inhibited TIMP-1 secretion and expression by human umbilical vein endothelial cells. In contrast, PMA stimulated TIMP-1 expression and secretion. Both oxLDL and PMA increased MMP-1 expression and secretion significantly as previously reported. Inhibition by oxLDL of TIMP-1 expression was also observed in human aortic endothelial cells. Collagenase activity as detected by an enzymatic activity assay demonstrated, as expected, an increase in collagenase activity in the culture medium from oxLDL-treated cells as compared with that from untreated cells. The presented data indicates that oxLDL differentially regulates TIMP-1 and MMP-1 expression, whereas PMA coordinately regulates TIMP-1 and MMP-1 in vascular endothelial cells. The lack of coordination in the secretion of MMP-1 and TIMP-1 induced by oxLDL leads to an increased collagen-degrading activity that may contribute to destabilization of atherosclerotic plaques. JF - Atherosclerosis AU - Huang, Y AU - Song, L AU - Wu, S AU - Fan, F AU - Lopes-Virella, M F AD - Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC 29401, USA. huangyan@musc.edu Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 119 EP - 125 VL - 156 IS - 1 SN - 0021-9150, 0021-9150 KW - Culture Media KW - 0 KW - Lipoproteins, LDL KW - Tissue Inhibitor of Metalloproteinase-1 KW - oxidized low density lipoprotein KW - Collagenases KW - EC 3.4.24.- KW - Matrix Metalloproteinase 1 KW - EC 3.4.24.7 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Umbilical Veins -- metabolism KW - Cells, Cultured KW - Humans KW - Collagenases -- analysis KW - Umbilical Veins -- cytology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Umbilical Veins -- drug effects KW - Culture Media -- chemistry KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Matrix Metalloproteinase 1 -- metabolism KW - Endothelium, Vascular -- cytology KW - Tissue Inhibitor of Metalloproteinase-1 -- metabolism KW - Lipoproteins, LDL -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70858880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atherosclerosis&rft.atitle=Oxidized+LDL+differentially+regulates+MMP-1+and+TIMP-1+expression+in+vascular+endothelial+cells.&rft.au=Huang%2C+Y%3BSong%2C+L%3BWu%2C+S%3BFan%2C+F%3BLopes-Virella%2C+M+F&rft.aulast=Huang&rft.aufirst=Y&rft.date=2001-05-01&rft.volume=156&rft.issue=1&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Atherosclerosis&rft.issn=00219150&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-23 N1 - Date created - 2001-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of Persian Gulf veterans with symptoms of peripheral neuropathy. AN - 70854814; 11370211 AB - Persian Gulf syndrome is a set of symptoms that do not fit into well-understood diagnostic categories. Among these symptoms, there are some that could suggest a generalized neuropathic process. Correlate neurological symptoms with objective electrodiagnostic findings. A randomized sample of 176 Persian Gulf veterans (PGV) evaluated at the San Juan Veterans Administration Medical Center was obtained. The subjects completed a questionnaire, and those who met the inclusion criteria underwent electrodiagnostic evaluation. Of the 176 PGV selected, 162 completed the questionnaire. The next step was to perform electrodiagnostic studies on those who described symptoms suggesting peripheral neuropathy and met the inclusion criteria. Twelve individuals met the inclusion criteria for electro-diagnostic studies. All studies were normal except that two subjects were found to have bilateral carpal tunnel syndrome. Although this is a relatively small sample of PGV, the findings are in accordance with other studies in which no definite generalized neuropathic pattern has been described. JF - Military medicine AU - Rivera-Zayas, J AU - Arroyo, M AU - Mejias, E AD - Department of Physical Medicine and Rehabilitation, San Juan Veterans Administration Medical Center, 672/151, 10 Casia Street, San Juan, Puerto Rico 00921-3201. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 449 EP - 451 VL - 166 IS - 5 SN - 0026-4075, 0026-4075 KW - Index Medicus KW - Warfare KW - Polyneuropathies -- diagnosis KW - Humans KW - Adult KW - Neurologic Examination KW - Middle Aged KW - Neuropsychological Tests KW - United States -- epidemiology KW - Male KW - Female KW - Polyneuropathies -- classification KW - Veterans KW - Peripheral Nervous System Diseases -- epidemiology KW - Peripheral Nervous System Diseases -- etiology KW - Persian Gulf Syndrome -- epidemiology KW - Persian Gulf Syndrome -- diagnosis KW - Persian Gulf Syndrome -- physiopathology KW - Peripheral Nervous System Diseases -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70854814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+medicine&rft.atitle=Evaluation+of+Persian+Gulf+veterans+with+symptoms+of+peripheral+neuropathy.&rft.au=Rivera-Zayas%2C+J%3BArroyo%2C+M%3BMejias%2C+E&rft.aulast=Rivera-Zayas&rft.aufirst=J&rft.date=2001-05-01&rft.volume=166&rft.issue=5&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=Military+medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-21 N1 - Date created - 2001-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Major depressive disorder. Psychopathology, medical management and dental implications. AN - 70841091; 11367967 AB - Major depressive disorder, or MDD, is a psychiatric illness in which mood, thoughts and behavioral patterns are impaired for long periods. The illness distresses the person and impairs his or her social functioning and quality of life. MDD is characterized by marked sadness or a loss of interest or pleasure in daily activities, and is accompanied by weight change, sleep disturbance, fatigue, difficulty concentrating, physical impairment and a high suicide rate. In 2000, the World Health Organization, or WHO, identified MDD as the fourth ranked cause of disability and premature death in the world. WHO projected that by 2020, MDD would rise in disease burden to be second only to ischemic heart disease. The disorder is common in the United States, with a lifetime prevalence rate of 17 percent and a recurrence rate of more than 50 percent. MDD may be associated with extensive dental disease, and people may seek dental treatment before becoming aware of their psychiatric illness. MDD frequently is associated with a disinterest in performing appropriate oral hygiene techniques, a cariogenic diet, diminished salivary flow, rampant dental caries, advanced periodontal disease and oral dysesthesias. Many medications used to treat the disease magnify the xerostomia and increase the incidence of dental disease. Appropriate dental management requires a vigorous dental education program, the use of saliva substitutes and anticaries agents containing fluoride, and special precautions when prescribing or administering analgesics and local anesthetics. Dentists cognizant of these signs and symptoms have an opportunity to recognize patients with occult MDD. After confirmation of the diagnosis and institution of treatment by a mental health practitioner, dentists usually can provide a full range of services that may enhance patients' self-esteem and contribute to the psychotherapeutic aspect of management. JF - Journal of the American Dental Association (1939) AU - Friedlander, A H AU - Mahler, M E AD - Veterans Affairs Greater Los Angeles Healthcare System (14), 11301 Wilshire Blvd., Los Angeles, Calif. 90073, USA. arthur.friedlander@med.va.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 629 EP - 638 VL - 132 IS - 5 SN - 0002-8177, 0002-8177 KW - Analgesics KW - 0 KW - Antidepressive Agents KW - Cariostatic Agents KW - Saliva, Artificial KW - Fluorides KW - Q80VPU408O KW - Dentistry KW - Index Medicus KW - Humans KW - Interpersonal Relations KW - Suicide KW - Aged KW - Quality of Life KW - Antidepressive Agents -- adverse effects KW - Fluorides -- therapeutic use KW - Dental Caries -- etiology KW - Xerostomia -- chemically induced KW - Saliva -- secretion KW - Sensation Disorders -- etiology KW - Diet, Cariogenic KW - Affect KW - Male KW - Saliva, Artificial -- therapeutic use KW - Cariostatic Agents -- therapeutic use KW - Periodontal Diseases -- etiology KW - Recurrence KW - Sleep Wake Disorders -- physiopathology KW - Fatigue -- physiopathology KW - Patient Education as Topic KW - Oral Hygiene KW - Antidepressive Agents -- therapeutic use KW - Middle Aged KW - Analgesics -- therapeutic use KW - Female KW - Prevalence KW - Depressive Disorder -- psychology KW - Depressive Disorder -- physiopathology KW - Depressive Disorder -- drug therapy KW - Dental Care for Chronically Ill UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70841091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Major+depressive+disorder.+Psychopathology%2C+medical+management+and+dental+implications.&rft.au=Friedlander%2C+A+H%3BMahler%2C+M+E&rft.aulast=Friedlander&rft.aufirst=A&rft.date=2001-05-01&rft.volume=132&rft.issue=5&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-26 N1 - Date created - 2001-05-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Am Dent Assoc 2001 Jun;132(6):736 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Asbestos causes apoptosis in alveolar epithelial cells: role of iron-induced free radicals. AN - 70821746; 11329530 AB - Asbestos causes asbestosis and malignancies by mechanisms that are not fully understood. Alveolar epithelial cell (AEC) injury by iron-induced reactive oxygen species (ROS) is one important mechanism. To determine whether asbestos causes apoptosis in AECs, we exposed WI-26 (human type I-like cells), A549 (human type II-like cells), and rat alveolar type II cells to amosite asbestos and assessed apoptosis by terminal deoxynucleotidyl transferase-mediated deoxyuridine-5'-triphosphate-biotin nick end labeling (TUNEL) staining, nuclear morphology, annexin V staining, DNA nucleosome formation, and caspase 3 activation. In contrast to control medium and TiO2, amosite asbestos and H2O2 each caused AEC apoptosis. A role for iron-catalyzed ROS was suggested by the finding that asbestos-induced AEC apoptosis and caspase 3 activation were each attenuated by either an iron chelator (phytic acid and deferoxamine) or a.OH scavenger (dimethyl-thiourea, salicylate, and sodium benzoate) but not by iron-loaded phytic acid. To determine whether asbestos causes apoptosis in vivo, rats received a single intratracheal instillation of amosite (5 mg) or normal saline solution, and apoptosis in epithelial cells in the bronchoalveolar duct regions was assessed by TUNEL staining. One week after exposure, amosite asbestos caused a 3-fold increase in the percentage of apoptotic cells in the bronchoalveolar duct regions as compared with control (control, 2.1% +/- 0.35%; asbestos, 7.61% +/- 0.15%; n = 3). However, by 4 weeks the number of apoptotic cells was similar to control. We conclude that asbestos-induced pulmonary toxicity may partly be caused by apoptosis in the lung epithelium that is mediated by iron-catalyzed ROS and caspase 3 activation. JF - The Journal of laboratory and clinical medicine AU - Aljandali, A AU - Pollack, H AU - Yeldandi, A AU - Li, Y AU - Weitzman, S A AU - Kamp, D W AD - Department of Medicine, Divisions of Pulmonary and Critical Care Medicine and Hematology-Oncology, Northwestern University Medical School and Veterans Administration Chicago Health Care System, Lakeside Division, IL, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 330 EP - 339 VL - 137 IS - 5 SN - 0022-2143, 0022-2143 KW - Free Radical Scavengers KW - 0 KW - Iron Chelating Agents KW - Reactive Oxygen Species KW - Asbestos, Amosite KW - 12172-73-5 KW - Hydroxyl Radical KW - 3352-57-6 KW - Phytic Acid KW - 7IGF0S7R8I KW - Hydrogen Peroxide KW - BBX060AN9V KW - Iron KW - E1UOL152H7 KW - CASP3 protein, human KW - EC 3.4.22.- KW - Casp3 protein, rat KW - Caspase 3 KW - Caspases KW - Sodium Benzoate KW - OJ245FE5EU KW - Abridged Index Medicus KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Cell Count KW - Dose-Response Relationship, Drug KW - Hydroxyl Radical -- metabolism KW - Humans KW - Intubation, Intratracheal KW - Sodium Benzoate -- pharmacology KW - Iron Chelating Agents -- pharmacology KW - Iron -- metabolism KW - Caspases -- metabolism KW - Rats KW - Hydrogen Peroxide -- toxicity KW - In Situ Nick-End Labeling KW - Rats, Sprague-Dawley KW - Cells, Cultured KW - Instillation, Drug KW - Phytic Acid -- pharmacology KW - Free Radical Scavengers -- pharmacology KW - Epithelial Cells -- metabolism KW - Asbestos, Amosite -- administration & dosage KW - Epithelial Cells -- cytology KW - Epithelial Cells -- drug effects KW - Apoptosis KW - Pulmonary Alveoli -- metabolism KW - Bronchi -- cytology KW - Asbestos, Amosite -- toxicity KW - Pulmonary Alveoli -- drug effects KW - Pulmonary Alveoli -- cytology KW - Bronchi -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70821746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+laboratory+and+clinical+medicine&rft.atitle=Asbestos+causes+apoptosis+in+alveolar+epithelial+cells%3A+role+of+iron-induced+free+radicals.&rft.au=Aljandali%2C+A%3BPollack%2C+H%3BYeldandi%2C+A%3BLi%2C+Y%3BWeitzman%2C+S+A%3BKamp%2C+D+W&rft.aulast=Aljandali&rft.aufirst=A&rft.date=2001-05-01&rft.volume=137&rft.issue=5&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+laboratory+and+clinical+medicine&rft.issn=00222143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-05-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Lab Clin Med. 2001 May;137(5):314-5 [11329527] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vascular insulin/insulin-like growth factor-1 resistance in female obese Zucker rats. AN - 70816566; 11319726 AB - Because insulin resistance/diabetes may cause inordinate vascular complications in females, we have investigated the effects of insulin and insulin-like growth factor (IGF-1) on vascular reactivity in 12-week-old female Zucker obese (Ob) rats, a rodent model of insulin resistance and its lean (Ln) age-matched counterpart. Endothelium intact aortic rings from Ob animals and their Ln littermates (12 weeks of age) were subjected to contractile concentration responses to phenylephrine (PE) followed by relaxation to isoproterenol (Iso), with and without preincubation for 2 hours with cholera toxin (CTX; 1 microg/mL) or pertussis toxin (PTX; 2 microg/mL) and before and after incubation with either insulin or IGF-1 (100 nmol/L) for 1 hour. Systolic blood pressure was higher (138 +/- 3 v. 109 +/- 4 mm Hg; P <.0001) in the 12-week-old Ob rats. Contractile responses to PE were similar in both groups; however, both insulin and IGF-1 induced a paradoxical increase (P <.001) in contraction in Ob vasculature (929 +/- 92 v. 679 +/- 25 mg, respectively). CTX alone decreased contraction in the Ob (P <.02) and PTX in the Ln (P <.02), but there were no interactions between either IGF-1 or insulin and the toxins. Marked impairment of relaxation to Iso was seen in aortic rings of these female Ob rats (ED(50) = 2.6 micromol/L v. 418 nmol/L, P =.0002), an effect exacerbated by preincubation with either insulin or IGF-1 (P =.0001). Again, no role for G-proteins could be demonstrated. Insulin-dependent glucose uptake was severely impaired (P <.05) in aortic segments of the Ob insulin-resistant rats. Insulin receptor binding, tyrosine kinase activity (TKA), and abundance of several G-protein alpha subunits (inhibitory and stimulatory) in solubilized arterial membrane preparations (assessed by Western blot) were comparable in the 2 groups. These results indicate that resistance to the vascular actions of insulin/IGF-1 in female Ob rats is a postreceptor event that parallels glucose uptake resistance and is independent of G-proteins. Copyright 2001 by W.B. Saunders Company. JF - Metabolism: clinical and experimental AU - Walsh, M F AU - Ali, S S AU - Sowers, J R AD - Division of Endocrinology, Diabetes, and Hypertension, SUNY Health Science Center at Brooklyn, and Veterans Administration Medical Center (VAMC) Brooklyn, Brooklyn, NY, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 607 EP - 612 VL - 50 IS - 5 SN - 0026-0495, 0026-0495 KW - Virulence Factors, Bordetella KW - 0 KW - Tritium KW - 10028-17-8 KW - Phenylephrine KW - 1WS297W6MV KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Cholera Toxin KW - 9012-63-9 KW - Deoxyglucose KW - 9G2MP84A8W KW - Pertussis Toxin KW - EC 2.4.2.31 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Receptor, Insulin KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Isoproterenol KW - L628TT009W KW - Index Medicus KW - Animals KW - Aorta KW - Cholera Toxin -- pharmacology KW - GTP-Binding Proteins -- physiology KW - Muscle Relaxation -- drug effects KW - Protein-Tyrosine Kinases -- metabolism KW - Rats, Zucker KW - Endothelium, Vascular KW - Isoproterenol -- pharmacology KW - Rats KW - Virulence Factors, Bordetella -- pharmacology KW - Muscle Contraction -- drug effects KW - Female KW - Receptor, Insulin -- metabolism KW - Deoxyglucose -- metabolism KW - Phenylephrine -- pharmacology KW - Muscle, Smooth, Vascular -- physiopathology KW - Muscle, Smooth, Vascular -- drug effects KW - Drug Resistance KW - Insulin Resistance KW - Obesity -- physiopathology KW - Insulin-Like Growth Factor I -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70816566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolism%3A+clinical+and+experimental&rft.atitle=Vascular+insulin%2Finsulin-like+growth+factor-1+resistance+in+female+obese+Zucker+rats.&rft.au=Walsh%2C+M+F%3BAli%2C+S+S%3BSowers%2C+J+R&rft.aulast=Walsh&rft.aufirst=M&rft.date=2001-05-01&rft.volume=50&rft.issue=5&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Metabolism%3A+clinical+and+experimental&rft.issn=00260495&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A meta-analysis comparing buprenorphine to methadone for treatment of opiate dependence. AN - 70798058; 11331027 AB - The unique pharmacological properties of buprenorphine may make it a useful maintenance therapy for opiate addiction. This meta-analysis considers the effectiveness of buprenorphine relative to methadone. A systematic literature search identified five randomized clinical trials comparing buprenorphine to methadone. Data from these trials were obtained. Retention in treatment was analyzed with a Cox proportional hazards regression. Urinalyses for opiates were studied with analysis of variance and a common method of handling missing values. A meta-analysis was used to combine these results. Subjects who received 8-12 mg/day buprenorphine had 1.26 times the relative risk of discontinuing treatment (95% confidence interval 1.01-1.57) and 8.3% more positive urinalyses (95% confidence interval 2.7-14%) than subjects receiving 50-80 mg/day methadone. Buprenophrine was more effective than 20-35 mg/day methadone. There was substantial variation in outcomes in the different trials. The variation between trials may be due to differences in dose levels, patient exclusion criteria and provision of psychosocial treatment. The difference in the effectiveness of buprenorphine and methadone may be statistically significant, but the differences are small compared to the wide variance in outcomes achieved in different methadone treatment programs. Further research is needed to determine if buprenorphine treatment is more effective than methadone in particular settings or in particular subgroups of patients. JF - Addiction (Abingdon, England) AU - Barnett, P G AU - Rodgers, J H AU - Bloch, D A AD - Cooperative Studies Program and Health Economics Resource Center, VA Palo Alto Health Care System, US Department of Veterans Affairs, Menlo Park, CA 94025, USA. paul.barnett@med.va.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 683 EP - 690 VL - 96 IS - 5 SN - 0965-2140, 0965-2140 KW - Narcotics KW - 0 KW - Buprenorphine KW - 40D3SCR4GZ KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Analysis of Variance KW - Patient Compliance KW - Humans KW - Treatment Outcome KW - Patient Dropouts -- statistics & numerical data KW - Proportional Hazards Models KW - Methadone -- therapeutic use KW - Buprenorphine -- therapeutic use KW - Narcotics -- urine KW - Narcotics -- therapeutic use KW - Opioid-Related Disorders -- rehabilitation KW - Opioid-Related Disorders -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70798058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=A+meta-analysis+comparing+buprenorphine+to+methadone+for+treatment+of+opiate+dependence.&rft.au=Barnett%2C+P+G%3BRodgers%2C+J+H%3BBloch%2C+D+A&rft.aulast=Barnett&rft.aufirst=P&rft.date=2001-05-01&rft.volume=96&rft.issue=5&rft.spage=683&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-14 N1 - Date created - 2001-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antibiotic Susceptibilities of Genetically Characterized Streptococcus milleri Group Strains AN - 17882174; 5117520 AB - Previous studies of the antibiotic susceptibility of Streptococcus milleri group organisms have distinguished among species by using phenotypic techniques. Using 44 isolates that were speciated by 16S rRNA gene sequencing, we studied the MICs and minimum bactericidal concentrations of penicillin, ampicillin, ceftriaxone, and clindamycin for Streptococcus intermedius, Streptococcus constellatus, and Streptococcus anginosus. None of the organisms was resistant to beta-lactam antibiotics, although a few isolates were intermediately resistant; one strain of S. anginosus was tolerant to ampicillin, and another was tolerant to ceftriaxone. Six isolates were resistant to clindamycin, with representation from each of the three species. Relatively small differences in antibiotic susceptibilities among species of the S. milleri group show that speciation is unlikely to be important in selecting an antibiotic to treat infection caused by one of these isolates. JF - Antimicrobial Agents & Chemotherapy AU - Tracy, M AU - Wanahita, A AU - Shuhatovich, Y AU - Goldsmith, E A AU - Clarridge, JE III AU - Musher, D M AD - Infectious Disease Section, Veterans Affairs Medical Center, Houston, TX 77030, USA, daniel.musher@med.va.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 1511 EP - 1514 VL - 45 IS - 5 SN - 0066-4804, 0066-4804 KW - isolates KW - rRNA 16S KW - Microbiology Abstracts B: Bacteriology KW - Speciation KW - Antibiotic sensitivity testing KW - Streptococcus milleri KW - ^b-Lactam antibiotics KW - J 02783:Antibiotics: General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17882174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Antibiotic+Susceptibilities+of+Genetically+Characterized+Streptococcus+milleri+Group+Strains&rft.au=Tracy%2C+M%3BWanahita%2C+A%3BShuhatovich%2C+Y%3BGoldsmith%2C+E+A%3BClarridge%2C+JE+III%3BMusher%2C+D+M&rft.aulast=Tracy&rft.aufirst=M&rft.date=2001-05-01&rft.volume=45&rft.issue=5&rft.spage=1511&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus milleri; Antibiotic sensitivity testing; Speciation; ^b-Lactam antibiotics ER - TY - JOUR T1 - Spa Contributes to the Virulence of Type 18 Group A Streptococci AN - 17854698; 4875023 AB - Streptococcal protective antigen (Spa) is a newly described surface protein of group A streptococci that was recently shown to evoke protective antibodies (J. B. Dale, E. Y. Chiang, S. Liu, H. S. Courtney, and D. L. Hasty, J. Clin. Investig. 103:1261-1268, 1999). In this study, we have determined the complete sequence of the spa gene from type 18 streptococci. Purified, recombinant Spa protein evoked antibodies that were bactericidal against type 18 streptococci, confirming the presence of protective epitopes. Sera from patients with acute rheumatic fever contained antibodies against recombinant Spa, indicating that the Spa protein is expressed in vivo and is immunogenic in humans. To determine the role of Spa in the virulence of group A streptococci, we created a series of insertional mutants that were (i) Spa negative and M18 positive, (ii) Spa positive and M18 negative, and (iii) Spa negative and M18 negative. The mutants and the parent M18 strain (18-282) were used in assays to determine resistance to phagocytosis, growth in human blood, and mouse virulence. The results show that Spa is a virulence determinant of group A streptococci and that expression of both Spa and M18 is required for optimal virulence of type 18 streptococci. JF - Infection and Immunity AU - McLellan, DGJ AU - Chiang, E Y AU - Courtney, H S AU - Hasty, D L AU - Wei, S C AU - Hu, M C AU - Walls, MA AU - Bloom, J J AU - Dale, J B AD - VA Medical Center (11A), 1030 Jefferson Ave., Memphis, TN 38104, JAMES.DALE@MED.VA.GOV Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 2943 EP - 2949 VL - 69 IS - 5 SN - 0019-9567, 0019-9567 KW - nucleotide sequence KW - streptococci KW - Streptococcal protective antigen KW - psa gene KW - rheumatic fever KW - Microbiology Abstracts B: Bacteriology KW - Virulence KW - Streptococcus KW - J 02832:Antigenic properties and virulence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17854698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Spa+Contributes+to+the+Virulence+of+Type+18+Group+A+Streptococci&rft.au=McLellan%2C+DGJ%3BChiang%2C+E+Y%3BCourtney%2C+H+S%3BHasty%2C+D+L%3BWei%2C+S+C%3BHu%2C+M+C%3BWalls%2C+MA%3BBloom%2C+J+J%3BDale%2C+J+B&rft.aulast=McLellan&rft.aufirst=DGJ&rft.date=2001-05-01&rft.volume=69&rft.issue=5&rft.spage=2943&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.69.5.2943-2949.2001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus; Virulence DO - http://dx.doi.org/10.1128/IAI.69.5.2943-2949.2001 ER - TY - JOUR T1 - An update on hypercoagulable disorders. AN - 70798892; 11322838 AB - Venous thrombosis is a cause of considerable morbidity and is often responsible for chronic venous disorders that frequently lead to visits to dermatologists and others involved in wound healing. Over the past several years, many new causes of thrombophilia have been identified and have dramatically altered the approach to patients presenting with thrombosis. Newly described abnormalities associated with thrombophilia include the syndrome of activated protein C resistance, the prothrombin 20210A mutation, hyperhomocysteinemia, and elevated levels of coagulation factors VIII and XI. Clinicians can now frequently determine causes of thromboses that have previously been deemed idiopathic. JF - Archives of internal medicine AU - Federman, D G AU - Kirsner, R S AD - VA Connecticut HCS (11ACSL), 950 Campbell Ave, West Haven, CT 06516, USA. Federman.Daniel_G+@west-haven.va.gov Y1 - 2001/04/23/ PY - 2001 DA - 2001 Apr 23 SP - 1051 EP - 1056 VL - 161 IS - 8 SN - 0003-9926, 0003-9926 KW - Anticoagulants KW - 0 KW - Contraceptives, Oral KW - factor V Leiden KW - Warfarin KW - 5Q7ZVV76EI KW - Factor V KW - 9001-24-5 KW - Prothrombin KW - 9001-26-7 KW - Abridged Index Medicus KW - Index Medicus KW - Contraceptives, Oral -- adverse effects KW - Anticoagulants -- therapeutic use KW - Activated Protein C Resistance -- etiology KW - Humans KW - Activated Protein C Resistance -- blood KW - Pregnancy Complications, Cardiovascular -- etiology KW - Warfarin -- therapeutic use KW - Prothrombin -- genetics KW - Recurrence KW - Pregnancy KW - Factor V -- metabolism KW - Hyperhomocysteinemia -- complications KW - Risk Factors KW - Mutation KW - Female KW - Blood Coagulation Disorders -- etiology KW - Blood Coagulation Disorders -- drug therapy KW - Blood Coagulation Disorders -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70798892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=An+update+on+hypercoagulable+disorders.&rft.au=Federman%2C+D+G%3BKirsner%2C+R+S&rft.aulast=Federman&rft.aufirst=D&rft.date=2001-04-23&rft.volume=161&rft.issue=8&rft.spage=1051&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-10 N1 - Date created - 2001-04-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 2002 Mar 11;162(5):613-4 [11871942] Arch Intern Med. 2002 Mar 11;162(5):613; author reply 614 [11871941] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Serum cholesterol, suicidal behavior and impulsivity in cocaine-dependent patients. AN - 77066126; 11311927 AB - Relationships between serum cholesterol and suicidal behavior have been reported. As suicidal behavior is common in cocaine dependence, we looked for a relationship with serum cholesterol. To do this, we compared 57 cocaine-dependent patients who had attempted suicide with 111 cocaine-dependent patients who had never attempted suicide for their admission total serum cholesterol levels. We found that there were no significant differences between cocaine-dependent patients who had or had not attempted suicide in their total serum cholesterol levels. Also, there were no significant correlations between total serum cholesterol levels and scores on the Barratt Impulsivity Scale. Thus, admission total serum cholesterol does not appear to be clinically useful in the assessment of suicidal behavior in cocaine-dependent patients. JF - Psychiatry research AU - Roy, A AU - Gonzalez, B AU - Marcus, A AU - Berman, J AD - Psychiatry Service (116A), Department of Veterans Affairs, New Jersey Healthcare System, 385 Tremont Avenue, East Orange, NJ 07018, USA. Deborah.Strickland@med.va.gov Y1 - 2001/04/15/ PY - 2001 DA - 2001 Apr 15 SP - 243 EP - 247 VL - 101 IS - 3 SN - 0165-1781, 0165-1781 KW - Cholesterol KW - 97C5T2UQ7J KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Cholesterol -- blood KW - Suicide, Attempted -- statistics & numerical data KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- blood KW - Impulsive Behavior -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77066126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Serum+cholesterol%2C+suicidal+behavior+and+impulsivity+in+cocaine-dependent+patients.&rft.au=Roy%2C+A%3BGonzalez%2C+B%3BMarcus%2C+A%3BBerman%2C+J&rft.aulast=Roy&rft.aufirst=A&rft.date=2001-04-15&rft.volume=101&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-05 N1 - Date created - 2001-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Verbal Learning and Memory Deficits in Traumatic Brain Injury: Encoding, Consolidation, and Retrieval AN - 85542026; 200113303 AB - The present study examined the nature of verbal memory deficits in individuals with traumatic brain injury compared to healthy controls. The study was designed to control for methodological shortcomings of previous related research. Three groups of participants were used: (1) a head injured sample with moderate to severe traumatic brain injuries (N = 55), (2) a control sample matched on age & initial performance on CVLT Trial 5 & Sum of Trials 1 to 5 (N = 55), & (3) a control sample matched on age, education, & race, but not on initial CVLT learning performance (N = 55). Current findings indicate that: (A) rate of learning was comparable across groups, consistent with no encoding differences, (B) traumatic brain injury patients have a significantly more rapid rate of forgetting of new information than either acquisition-matched or demographic-matched controls, consistent with consolidation problems in traumatic brain injury, (C) traumatic brain injury patients have less proactive interference than demographic-matched control participants, consistent with a consolidation problem in the traumatic brain injury group, (D) traumatic brain injury patients & acquisition-matched controls have comparably low rates of proactive interference, consistent with impaired acquisition in both of these groups, & (E) traumatic brain injury patients & controls do not differ in the benefit experienced from semantic or recognition retrieval cues, consistent with no differences in retrieval processes. These data support an impaired consolidation hypothesis, rather than encoding or retrieval deficits, as the primary deficit underlying memory impairment in traumatic brain injury. 2 Tables, 2 Figures, 35 References. Adapted from the source document JF - Journal of Clinical and Experimental Neuropsychology AU - Vanderploeg, Rodney D AU - Crowell, Timothy A AU - Curtiss, Glenn AD - Psychology Service, James A. Haley Veterans Hospital, Tampa, FL Rodney.Vanderploeg@med.va.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 185 EP - 195 VL - 23 IS - 2 SN - 1380-3395, 1380-3395 KW - Brain Damage (09400) KW - Verbal Learning (93750) KW - Memory Disorders (52800) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85542026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+and+Experimental+Neuropsychology&rft.atitle=Verbal+Learning+and+Memory+Deficits+in+Traumatic+Brain+Injury%3A+Encoding%2C+Consolidation%2C+and+Retrieval&rft.au=Vanderploeg%2C+Rodney+D%3BCrowell%2C+Timothy+A%3BCurtiss%2C+Glenn&rft.aulast=Vanderploeg&rft.aufirst=Rodney&rft.date=2001-04-01&rft.volume=23&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+and+Experimental+Neuropsychology&rft.issn=13803395&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCENE8 N1 - SubjectsTermNotLitGenreText - Verbal Learning (93750); Memory Disorders (52800); Brain Damage (09400) ER - TY - JOUR T1 - Combined androgen blockade with nonsteroidal antiandrogens for advanced prostate cancer: a systematic review. AN - 77063879; 11306391 AB - Combined androgen blockade with medical or surgical castration plus a nonsteroidal antiandrogen for metastatic prostate cancer has been the subject of 20 randomized trials. The findings range from no expected increase in survival in 17 studies to an estimated 3.7 to 7 months' survival improvement noted in 3 studies. Most recently, a 1999 evidence report from the Agency for Healthcare Research and Quality and a 2000 overview from the Prostate Cancer Trialists Collaborative Group indicated that combined androgen blockade was associated with an approximately 3% to 5% increase in 5-year survival. We report herein a systematic review on combined androgen blockade performed by the Cochrane Collaborative Review Group on Prostate Diseases. Controlled trials that included a randomization of immediate nonsteroidal antiandrogens with castration versus castration alone for metastatic prostate cancer and provided information on survival were reviewed. Information on overall survival, toxicity, progression-free survival, cancer-specific survival, and type of nonsteroidal antiandrogen and castration therapies was abstracted by two independent reviewers. Twenty trials (n = 6320 patients) were included. The pooled odds ratio (OR) for overall survival with combined androgen blockade was 1.03 (95% confidence interval [CI] 0.85 to 1.25; n = 4970 from 13 trials), 1.16 (95% CI 1.00 to 1.33; n = 5286 from 14 trials), and 1.29 (95% CI 1.11 to 1.50; n = 3550 from 7 trials) at 1, 2, and 5 years, respectively. Progression-free survival was improved at 1 year (OR = 1.38; 95% CI 1.15 to 1.67; n = 2278 from 7 trials). Cancer-specific survival was improved at 5 years (OR = 1.58; 95% CI 1.05 to 2.37; n = 781 from 2 trials). When analysis was limited to studies identified as being of high quality, the pooled OR for overall survival progressively increased but was not significant at any follow-up interval. We find that there is a 5% improvement in the percentage of men surviving at 5 years (30% vs. 25%) with combined androgen blockade with nonsteroidal antiandrogens as well as improvements in progression-free survival at 1 year. Appropriate patients with metastatic prostate cancer should be informed of the potential benefits, toxicities, and out-of-pocket expenditures. JF - Urology AU - Schmitt, B AU - Wilt, T J AU - Schellhammer, P F AU - DeMasi, V AU - Sartor, O AU - Crawford, E D AU - Bennett, C L AD - Veterans Administration Chicago Healthcare System/Lakeside Division, Chicago, Illinois, USA. Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 727 EP - 732 VL - 57 IS - 4 KW - Androgen Antagonists KW - 0 KW - Imidazoles KW - Imidazolidines KW - nilutamide KW - 51G6I8B902 KW - Flutamide KW - 76W6J0943E KW - Index Medicus KW - Disease-Free Survival KW - Humans KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Male KW - Chemotherapy, Adjuvant KW - Orchiectomy KW - Prostatic Neoplasms -- mortality KW - Androgen Antagonists -- therapeutic use KW - Prostatic Neoplasms -- surgery KW - Imidazoles -- administration & dosage KW - Prostatic Neoplasms -- drug therapy KW - Flutamide -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77063879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urology&rft.atitle=Combined+androgen+blockade+with+nonsteroidal+antiandrogens+for+advanced+prostate+cancer%3A+a+systematic+review.&rft.au=Schmitt%2C+B%3BWilt%2C+T+J%3BSchellhammer%2C+P+F%3BDeMasi%2C+V%3BSartor%2C+O%3BCrawford%2C+E+D%3BBennett%2C+C+L&rft.aulast=Schmitt&rft.aufirst=B&rft.date=2001-04-01&rft.volume=57&rft.issue=4&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Urology&rft.issn=1527-9995&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-21 N1 - Date created - 2001-04-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Music and the PACU environment. AN - 77034710; 11290990 AB - Pain is a common problem in the PACU, resulting in negative respiratory, cardiovascular, gastrointestinal, renal, neuroendocrine, and autonomic nervous system consequences for patients. Pain relief contributes to improved patient outcomes and is also an important component of patient satisfaction, particularly in light of today's environment of high competition among hospitals for patients. Music and quiet conversation by staff, contributing to low noise levels in the PACU environment, have the potential to provide pain relief and improve patient satisfaction with the PACU experience. This study investigated the effect of soothing music and lowering noise levels on the pain experience of patients during their PACU stay. A quasiexperimental study was conducted with 2 groups of patients, one who listened to music on a day when staff kept extraneous noise at a minimum in the PACU (the experimental group) and one who experienced the typical PACU day (the control group). The study was conducted at a large Veterans Administration hospital in the Midwest. The sample consisted of 97 individuals undergoing same-day surgery from all surgery services except open heart. Pain was measured by using the 11-point Numerical Rating Scale (NRS). The experimental group experienced a significant reduction in pain from admission to the PACU until discharge. There was no significant decrease for the control group. Approximately 65% of both groups reported no pain on admission to PACU. The percentage of those in the experimental group with no pain increased to 74% at time of discharge. The percentage of those in the control group who reported no pain on discharge had decreased to 58%. A total of 99% of the participants remembered their PACU stay. When asked to remember aspects of comfort during the PACU stay, the experimental group reported (1) significantly less noise caused by staff voices and equipment, (2) greater perception of availability of nurses, and (3) significantly more positive perception of their PACU stay. The study findings support the potential for music played throughout the PACU stay to positively affect the pain experience and improve comfort among patients having surgery. Copyright 2001 by American Society of PeriAnesthesia Nurses. JF - Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses AU - Shertzer, K E AU - Keck, J F AD - Richard L. Roudebush Veterans Administration Hospital, Indianapolis, IN, USA. Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 90 EP - 102 VL - 16 IS - 2 SN - 1089-9472, 1089-9472 KW - Nursing KW - Attitude to Health KW - Humans KW - Pain Measurement KW - Midwestern United States KW - Middle Aged KW - Postanesthesia Nursing KW - Time Factors KW - Noise -- adverse effects KW - Male KW - Female KW - Hospitals, Veterans KW - Pain, Postoperative -- prevention & control KW - Pain, Postoperative -- etiology KW - Pain, Postoperative -- diagnosis KW - Recovery Room -- organization & administration KW - Music Therapy -- standards KW - Music Therapy -- methods KW - Health Facility Environment -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77034710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+perianesthesia+nursing+%3A+official+journal+of+the+American+Society+of+PeriAnesthesia+Nurses&rft.atitle=Music+and+the+PACU+environment.&rft.au=Shertzer%2C+K+E%3BKeck%2C+J+F&rft.aulast=Shertzer&rft.aufirst=K&rft.date=2001-04-01&rft.volume=16&rft.issue=2&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Journal+of+perianesthesia+nursing+%3A+official+journal+of+the+American+Society+of+PeriAnesthesia+Nurses&rft.issn=10899472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-15 N1 - Date created - 2001-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An integrative approach for studying the etiology of alcoholism and other addictions. AN - 72218397; 11665331 AB - Studies of alcoholism etiology often focus on genetic or psychosocial approaches, but not both. Greater understanding of the etiology of alcohol, tobacco and other addictions will come from integration of these research traditions. A research approach is outlined to test three models for the etiology of addictions--behavioral undercontrol, pharmacologic vulnerability, negative affect regulation--addressing key questions including (i) mediators of genetic effects, (ii) genotype-environment correlation effects, (iii) genotype x environment interaction effects, (iv) the developmental unfolding of genetic and environmental effects, (v) subtyping including identification of distinct trajectories of substance involvement, (vi) identification of individual genes that contribute to risk, and (vii) the consequences of excessive use. By using coordinated research designs, including prospective assessment of adolescent twins and their siblings and parents; of adult substance dependent and control twins and their MZ and DZ cotwins, the spouses of these pairs, and their adolescent offspring; and of regular families; by selecting for gene-mapping approaches sibships screened for extreme concordance or discordance on quantitative indices of substance use; and by using experimental (drug challenge) as well as survey approaches, a number of key questions concerning addiction etiology can be addressed. We discuss complementary strengths and weaknesses of different sampling strategies, as well as methods to implement such an integrated approach illustrated for the study of alcoholism etiology. A coordinated program of twin and family studies will allow a comprehensive dissection of the interplay of genetic and environmental risk-factors in the etiology of alcoholism and other addictions. JF - Twin research : the official journal of the International Society for Twin Studies AU - Jacob, T AU - Sher, K J AU - Bucholz, K K AU - True, W T AU - Sirevaag, E J AU - Rohrbaugh, J AU - Nelson, E AU - Neuman, R J AU - Todd, R D AU - Slutske, W S AU - Whitfield, J B AU - Kirk, K M AU - Martin, N G AU - Madden, P A AU - Heath, A C AD - Palo Alto Veterans Administration, Palo Alto, California, USA. Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 103 EP - 118 VL - 4 IS - 2 SN - 1369-0523, 1369-0523 KW - Index Medicus KW - Twin Studies as Topic -- methods KW - Models, Psychological KW - Risk Factors KW - Models, Genetic KW - Humans KW - Sampling Studies KW - Family KW - Parent-Child Relations KW - Research Design KW - Male KW - Female KW - Spouses KW - Alcoholism -- etiology KW - Behavior, Addictive -- etiology KW - Behavior, Addictive -- psychology KW - Diseases in Twins -- etiology KW - Alcoholism -- genetics KW - Behavior, Addictive -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72218397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Twin+research+%3A+the+official+journal+of+the+International+Society+for+Twin+Studies&rft.atitle=An+integrative+approach+for+studying+the+etiology+of+alcoholism+and+other+addictions.&rft.au=Jacob%2C+T%3BSher%2C+K+J%3BBucholz%2C+K+K%3BTrue%2C+W+T%3BSirevaag%2C+E+J%3BRohrbaugh%2C+J%3BNelson%2C+E%3BNeuman%2C+R+J%3BTodd%2C+R+D%3BSlutske%2C+W+S%3BWhitfield%2C+J+B%3BKirk%2C+K+M%3BMartin%2C+N+G%3BMadden%2C+P+A%3BHeath%2C+A+C&rft.aulast=Jacob&rft.aufirst=T&rft.date=2001-04-01&rft.volume=4&rft.issue=2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Twin+research+%3A+the+official+journal+of+the+International+Society+for+Twin+Studies&rft.issn=13690523&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prepulse inhibition of the acoustic startle response in cocaine-withdrawn rats. AN - 71133615; 11526973 AB - Prepulse inhibition (PPI) of startle is a sensorimotor gating task in which a low-intensity acoustic stimulus presented prior to a high-intensity, startle-eliciting stimulus can attenuate the acoustic startle response (ASR). Previous studies on startle reactivity in cocaine-withdrawn rats have found minimal changes; the present study extends this work to the gating of ASR. In Experiment 1, rats were injected daily with either saline or cocaine (30 mg/kg i.p.) for 2 weeks. ASR and PPI were measured prior to, and at 3- and 14-day withdrawal from, the chronic treatment. No effect of cocaine treatment was found on either measure. In Experiment 2, treatment was extended to 8 weeks, and an earlier withdrawal time point (1 day) was added. Rats treated with cocaine for 8 weeks exhibited lower startle reactivity during withdrawal compared with saline-treated controls. PPI did not differ between treatment groups. Thus, extended chronic treatment with cocaine rendered significant effects on startle responsivity. Further, this finding mirrors the blunted ASR exhibited in chronic cocaine users [Neuropsychopharmacology 22 (2000) 89.]. JF - Pharmacology, biochemistry, and behavior AU - Adams, J U AU - Efferen, T R AU - Duncan, E J AU - Rotrosen, J AD - Mental Health Research, New York Harbor Department of Veterans Affairs Health Care System, Department of Psychiatry, New York University School of Medicine, NY 10010, USA. adams.jill@new-york.va.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 753 EP - 759 VL - 68 IS - 4 SN - 0091-3057, 0091-3057 KW - Dopamine Uptake Inhibitors KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Acoustic Stimulation KW - Male KW - Reflex, Startle -- drug effects KW - Substance Withdrawal Syndrome -- physiopathology KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Reflex, Startle -- physiology KW - Neural Inhibition -- drug effects KW - Neural Inhibition -- physiology KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71133615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Prepulse+inhibition+of+the+acoustic+startle+response+in+cocaine-withdrawn+rats.&rft.au=Adams%2C+J+U%3BEfferen%2C+T+R%3BDuncan%2C+E+J%3BRotrosen%2C+J&rft.aulast=Adams&rft.aufirst=J&rft.date=2001-04-01&rft.volume=68&rft.issue=4&rft.spage=753&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Concurrent versus delayed smoking cessation treatment for persons in early alcohol recovery. A pilot study. AN - 71110253; 11516593 AB - This pilot study investigated the efficacy of initiating a smoking cessation intervention early in inpatient treatment for alcohol dependence versus shortly after an inpatient stay. Thirty-six male smokers recruited from an inpatient substance abuse treatment program were randomly assigned to begin smoking cessation either two weeks (concurrent treatment) or six weeks (delayed treatment) after admission to the substance abuse program. Smoking cessation treatment involved three sessions of individual smoking cessation treatment plus eight weeks of transdermal nicotine replacement. Significantly fewer participants began the delayed treatment than the concurrent treatment. Few participants were smoking-abstinent at follow-up, and the timing of treatment onset did not have an impact on smoking outcome. Clinical trials with larger samples may be needed to better evaluate the efficacy of concurrent versus delayed treatment and to test the efficacy of more aggressive interventions with smokers in early alcohol recovery. JF - Journal of substance abuse treatment AU - Kalman, D AU - Hayes, K AU - Colby, S M AU - Eaton, C A AU - Rohsenow, D J AU - Monti, P M AD - Boston University Medical School and Edith Nourse Rogers Memorial Veterans Affairs Medical Center, Boston, MA, USA. Kalman.David@bedford.va.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 233 EP - 238 VL - 20 IS - 3 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Substance Abuse Treatment Centers KW - Humans KW - Treatment Outcome KW - Time Factors KW - Male KW - Smoking Cessation -- psychology KW - Tobacco Use Disorder -- drug therapy KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71110253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Concurrent+versus+delayed+smoking+cessation+treatment+for+persons+in+early+alcohol+recovery.+A+pilot+study.&rft.au=Kalman%2C+D%3BHayes%2C+K%3BColby%2C+S+M%3BEaton%2C+C+A%3BRohsenow%2C+D+J%3BMonti%2C+P+M&rft.aulast=Kalman&rft.aufirst=D&rft.date=2001-04-01&rft.volume=20&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-11-01 N1 - Date created - 2001-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Girard's reagent P derivative of beta-Apo-8'-carotenal: a potent photoprotective agent. AN - 70811436; 11332029 AB - A cationic carotenoid derivative (GRP-carotenal) was synthesized by the reaction of Girard's reagent P and beta-apo-8'-carotenal. The singlet-oxygen quenching constants for GRP-carotenal were 1.3 +/- 0.1 x 10(10) and 1.0 +/- 0.1 x 10(10) M-1 s-1 in acetonitrile and in detergent micelles, respectively. Photosensitized damage to K562 leukemia cells from cis-di(4-sulfonatophenyl)diphenylporphine, hypericin and protoporphyrin IX was inhibited by GRP-carotenal under conditions where beta-apo-8'-carotenal, beta-carotene and crocetin were ineffective. The unique cytoprotective properties of GRP-carotenal, relative to the other carotenoids studied, could not be explained by the differences in the cell content of the various carotenoids or by the changes in the cell content of the photosensitizers used. Photosensitizer fluorescence from labeled K562 cells was reduced by GRP-carotenal but not by the other carotenoids studied. The novel photoprotective properties of GRP-carotenal may be due to its subcellular distribution. In photosensitizer-containing detergent micelles, novel properties of GRP-carotenal were not apparent. None of the carotenoids studied reduced photosensitizer fluorescence or singlet-oxygen generation. Singlet-oxygen quenching by GRP-carotenal and by beta-apo-8'-carotenal were roughly the same. Crocetin has a singlet-oxygen quenching constant that is about a factor of five lower. Singlet-oxygen quenching by beta-carotene was limited by its aggregation. JF - Photochemistry and photobiology AU - Kanofsky, J R AU - Sima, P D AD - Medical Service, Edward Hines Jr., Department of Veterans Affairs Hospital, Hines, IL, USA. jeff.kanofsky@med.va.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 349 EP - 358 VL - 73 IS - 4 SN - 0031-8655, 0031-8655 KW - GRP-carotenal KW - 0 KW - Photosensitizing Agents KW - Porphyrins KW - Protoporphyrins KW - di(4-sulfonatophenyl)diphenylporphine KW - Singlet Oxygen KW - 17778-80-2 KW - crocetin KW - 20TC155L9C KW - Carotenoids KW - 36-88-4 KW - Perylene KW - 5QD5427UN7 KW - hypericin KW - 7V2F1075HD KW - protoporphyrin IX KW - C2K325S808 KW - Oxygen KW - S88TT14065 KW - apocarotenal KW - V22N3E2U32 KW - Index Medicus KW - Photochemistry KW - Molecular Structure KW - Porphyrins -- toxicity KW - Photosensitizing Agents -- toxicity KW - Protoporphyrins -- toxicity KW - Humans KW - Oxygen -- chemistry KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Perylene -- analogs & derivatives KW - Tumor Cells, Cultured -- drug effects KW - Perylene -- toxicity KW - Carotenoids -- chemistry KW - K562 Cells -- drug effects KW - Carotenoids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70811436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Girard%27s+reagent+P+derivative+of+beta-Apo-8%27-carotenal%3A+a+potent+photoprotective+agent.&rft.au=Kanofsky%2C+J+R%3BSima%2C+P+D&rft.aulast=Kanofsky&rft.aufirst=J&rft.date=2001-04-01&rft.volume=73&rft.issue=4&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-24 N1 - Date created - 2001-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Health Status and Quality of Life in Romania AN - 61468438; 200105086 AB - The objective of this study was to examine health status & quality of life in northwestern Romania. The study utilized a descriptive, correlational design to examine the major study variables measured in 401 patients seen at a clinic. Instruments included the Medical Outcomes Study Short Form 36-item survey (MOSSF-36) as a measure of health status, the Quality of Life Index (QLI) as a measure of quality of life, & a demographic/health survey. The rationale for the study was to explore the crosscultural aspects of health status & quality of life in this former Eastern bloc country. Questionnaires were translated through classical forward & backward methods to achieve crosscultural comparability. Interviewers administered the questionnaires to participants at the clinic. The study findings indicated that health status was significantly related to quality of life. Scores on the MOSSF-36 indicated that the Romanian sample most often experienced limitations due to pain (66.9%). Other frequently cited reasons for clinic visits included consultation with health care provider, & cardiovascular, respiratory, & digestive problems. International measurement of outcome variables such as health status & quality of life is an important focus for interdisciplinary research. The link between these variables may provide further data to support the role of health care providers in assessment & intervention to improve quality of life. 4 Tables, 30 References. Adapted from the source document. JF - Issues in Interdisciplinary Care AU - Lakey, Cynthia K AU - Nicholas, Patrice Kenneally AU - Wolf, Karen A AU - Leuner, Jean D'Meza AU - Corless, Inge B AU - Paul-Simon, Alexandra AD - Veterans Administration Medical Center, Boston, MA Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 129 EP - 136 VL - 3 IS - 2 SN - 1531-5150, 1531-5150 KW - Postcommunist Societies KW - Romania KW - Quality of Life KW - Clinics KW - Patients KW - Health KW - Crosscultural Analysis KW - Health Care Utilization KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61468438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Issues+in+Interdisciplinary+Care&rft.atitle=Health+Status+and+Quality+of+Life+in+Romania&rft.au=Lakey%2C+Cynthia+K%3BNicholas%2C+Patrice+Kenneally%3BWolf%2C+Karen+A%3BLeuner%2C+Jean+D%27Meza%3BCorless%2C+Inge+B%3BPaul-Simon%2C+Alexandra&rft.aulast=Lakey&rft.aufirst=Cynthia&rft.date=2001-04-01&rft.volume=3&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Issues+in+Interdisciplinary+Care&rft.issn=15315150&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health; Quality of Life; Romania; Postcommunist Societies; Patients; Clinics; Crosscultural Analysis; Health Care Utilization ER - TY - JOUR T1 - A Psychometric Evaluation of the BDI-II in Treatment-Seeking Substance Abusers AN - 61441659; 200200638 AB - The Beck Depression Inventory-II (BDI-II) was administered to 416 consecutive male admissions to a 28-day residential chemical dependence treatment program as part of a routine intake procedure. Psychometric analyses revealed that the BDI-II scores were internally consistent in this treatment-seeking population based on coefficient alpha. The mean BDI-II score for patients in this study was higher than that noted for other clinical samples in previous studies. The use of BDI-II for clinical decision making with chemically dependent individuals is discussed in light of this elevated distribution of scores. Confirmatory factor-analytic examinations of the instrument revealed that a three-factor model, with cognitive, affective, & somatic symptoms loading as separate factors, provided the most adequate account of the data. In total, the study supported the use of the BDI-II for the assessment of depression in chemically dependent male patients entering a residential treatment program at a VAMC facility, provided population-specific normative data is utilized for making clinical decisions. 3 Tables, 1 Figure, 27 References. Adapted from the source document. JF - Journal of Substance Abuse Treatment AU - Buckley, Todd C AU - Parker, Jefferson D AU - Heggie, Jennifer AD - Boston Veterans Affairs Medical Center, MA todd.buckley@med.va.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 197 EP - 204 VL - 20 IS - 3 SN - 0740-5472, 0740-5472 KW - Help Seeking Behavior KW - Substance Abuse KW - Treatment Programs KW - Males KW - Mississippi KW - Psychometric Analysis KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61441659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=A+Psychometric+Evaluation+of+the+BDI-II+in+Treatment-Seeking+Substance+Abusers&rft.au=Buckley%2C+Todd+C%3BParker%2C+Jefferson+D%3BHeggie%2C+Jennifer&rft.aulast=Buckley&rft.aufirst=Todd&rft.date=2001-04-01&rft.volume=20&rft.issue=3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Substance Abuse; Psychometric Analysis; Help Seeking Behavior; Treatment Programs; Males; Mississippi ER - TY - JOUR T1 - Severe exercise alters the strength and mechanisms of the muscle metaboreflex AN - 18118196; 5210192 AB - Previous studies have shown that in dogs performing mild to moderate treadmill exercise, partial graded reductions in hindlimb blood flow cause active skeletal muscle to become ischemic and metabolites to accumulate thus evoking the muscle metaboreflex. This leads to a substantial reflex increase in mean arterial pressure (MAP) mediated almost solely via a rise in cardiac output (CO). However, during severe exercise CO is likely near maximal and thus metaboreflex-mediated increases in MAP may be attenuated. We therefore evoked the metaboreflex via partial graded reductions in hindlimb blood flow in seven dogs during mild, moderate, and severe treadmill exercise. During mild and moderate exercise there was a large rise in CO (1.5 plus or minus 0.2 and 2.2 plus or minus 0.3 1/min, respectively), whereas during severe exercise no significant increase in CO occurred. The rise in CO caused a marked pressor response that was significantly attenuated during severe exercise (26.3 plus or minus 7.0, 33.2 plus or minus 5.6, and 12.2 plus or minus 4.8 mmHg, respectively). We conclude that during severe exercise the metaboreflex pressor response mechanisms are altered such that the ability of this reflex to increase CO is abolished, and reduced pressor response occurs only via peripheral vasoconstriction. This shift in mechanisms likely limits the effectiveness of the metaboreflex to increase blood flow to ischemic active skeletal muscle. Furthermore, because the metaboreflex is a flow-raising reflex and not a pressure-raising reflex, it may be most appropriate to describe the metaboreflex magnitude based on its ability to evoke a rise in CO and not a rise in MAP. JF - American Journal of Physiology: Heart and Circulatory Physiology AU - Augustyniak, R A AU - Collins, H L AU - Ansorge, E J AU - Rossi, N F AU - O'Leary, D S AD - Department of Medicine, John D. Dingell Veterans Administration Medical Center, Detroit, Michigan 48201, USA Y1 - 2001/04// PY - 2001 DA - Apr 2001 SP - H1645 EP - H1652 VL - 280 IS - 4 SN - 0363-6135, 0363-6135 KW - Physical Education Index KW - Heart KW - Exercise physiology KW - Strength KW - Cardiac output KW - Blood flow KW - Circulatory system KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18118196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Heart+and+Circulatory+Physiology&rft.atitle=Severe+exercise+alters+the+strength+and+mechanisms+of+the+muscle+metaboreflex&rft.au=Augustyniak%2C+R+A%3BCollins%2C+H+L%3BAnsorge%2C+E+J%3BRossi%2C+N+F%3BO%27Leary%2C+D+S&rft.aulast=Augustyniak&rft.aufirst=R&rft.date=2001-04-01&rft.volume=280&rft.issue=4&rft.spage=H1645&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Heart+and+Circulatory+Physiology&rft.issn=03636135&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Strength; Exercise physiology; Heart; Circulatory system; Blood flow; Cardiac output ER - TY - JOUR T1 - The Military Environment: Risk Factors for Women's Non-Fatal Assaults AN - 17872407; 5120577 AB - Little is known regarding environmental exposures for non-fatal violence toward women in the workplace. We sought to identify factors associated with non-fatal physical assault occurring to women during military service. A cross-sectional telephone survey of a national sample of 558 women veterans who served in Vietnam and subsequent eras of military service was conducted; 537 women were interviewed. Twenty-three percent experienced non-fatal physical assault during military service. Rates of assault were consistent across eras of service. Military environmental exposures, including sexual harassment allowed by officers (P < 0.0001) and unwanted sexual advances while on duty (P < .0001) and in sleeping quarters (P < 0.0001), were independent risk factors for assault. Environmental factors in the military workplace, including leadership behavior, appeared to promote violence toward military women. Such occupational factors can be identified and should be eliminated. JF - Journal of Occupational and Environmental Medicine AU - Sadler, A G AU - Booth, B M AU - Cook, B L AU - Torner, J C AU - Doebbeling, B N AD - Post-Traumatic Stress Disorder Clinical Team Coordinator, (116B) Psychology Service, Veterans Administration Medical Center, Highway 6 West, Iowa City, IA 52246, USA Y1 - 2001/04// PY - 2001 DA - Apr 2001 SP - 325 EP - 334 VL - 43 IS - 4 SN - 1076-2752, 1076-2752 KW - physical assault KW - Risk Abstracts; Health & Safety Science Abstracts KW - Occupational safety KW - Violence KW - Females KW - Military KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17872407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=The+Military+Environment%3A+Risk+Factors+for+Women%27s+Non-Fatal+Assaults&rft.au=Sadler%2C+A+G%3BBooth%2C+B+M%3BCook%2C+B+L%3BTorner%2C+J+C%3BDoebbeling%2C+B+N&rft.aulast=Sadler&rft.aufirst=A&rft.date=2001-04-01&rft.volume=43&rft.issue=4&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Females; Military; Occupational safety; Violence ER - TY - JOUR T1 - Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection. AN - 76951810; 11237812 AB - Immunosuppressed Swiss Black mice deficient in surfactant protein A (SP-A(-/-)) and wild-type control mice (SP-A(+/+)) were exposed to Pneumocystis carinii by environmental exposure, intratracheal inoculation, and direct exposure to other infected animals. The frequency and intensity of P. carinii infection were significantly greater in the SP-A(-/-) mice by all 3 methods of exposure. P. carinii free of SP-A and alveolar macrophages were isolated from SP-A(-/-) mice and were tested in an in vitro attachment assay. Pretreatment of P. carinii with human SP-A resulted in a significant dose-dependent increase of the adherence of P. carinii to the macrophages. Thus, SP-A plays a role in host defense against P. carinii in vivo, perhaps by functioning as a nonimmune opsonin. JF - The Journal of infectious diseases AU - Linke, M J AU - Harris, C E AU - Korfhagen, T R AU - McCormack, F X AU - Ashbaugh, A D AU - Steele, P AU - Whitsett, J A AU - Walzer, P D AD - Research Service, Department of Veterans Affairs Medical Center, and Divisions of Infectious Diseases and Pulmonary/Critical Care Medicine, University of Cincinnati, Cincinnati, OH 45220, USA. Michael.Linke@med.va.gov Y1 - 2001/03/15/ PY - 2001 DA - 2001 Mar 15 SP - 943 EP - 952 VL - 183 IS - 6 SN - 0022-1899, 0022-1899 KW - Proteolipids KW - 0 KW - Pulmonary Surfactant-Associated Protein A KW - Pulmonary Surfactant-Associated Proteins KW - Pulmonary Surfactants KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Pneumonia, Pneumocystis -- immunology KW - Disease Susceptibility KW - Mice KW - Lung -- pathology KW - Mice, Knockout KW - Pneumonia, Pneumocystis -- microbiology KW - Pneumonia, Pneumocystis -- pathology KW - Cells, Cultured KW - Trachea -- microbiology KW - Environmental Exposure KW - Mice, Inbred C3H KW - Bacterial Adhesion KW - Macrophages, Alveolar -- immunology KW - Lung -- microbiology KW - Proteolipids -- genetics KW - Proteolipids -- pharmacology KW - Pulmonary Surfactants -- physiology KW - Pneumocystis -- cytology KW - Pulmonary Surfactants -- genetics KW - Pulmonary Surfactants -- pharmacology KW - Immunocompromised Host KW - Proteolipids -- physiology KW - Pneumocystis -- pathogenicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76951810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Immunosuppressed+surfactant+protein+A-deficient+mice+have+increased+susceptibility+to+Pneumocystis+carinii+infection.&rft.au=Linke%2C+M+J%3BHarris%2C+C+E%3BKorfhagen%2C+T+R%3BMcCormack%2C+F+X%3BAshbaugh%2C+A+D%3BSteele%2C+P%3BWhitsett%2C+J+A%3BWalzer%2C+P+D&rft.aulast=Linke&rft.aufirst=M&rft.date=2001-03-15&rft.volume=183&rft.issue=6&rft.spage=943&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-05 N1 - Date created - 2001-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Darley and the Efficacy of Language Rehabilitation in Aphasia AN - 85346114; llba-200107388 AB - The efficacy of language rehabilitation programs in helping individuals with aphasia is investigated. An overview of Fredric Darley's (1972) examination of the effectiveness of language rehabilitation in aphasia is presented; the significant influence of Darley's research on future studies of language rehabilitation's efficacy is also noted. R. R. Robey & M. C. Schultz's (1998) provision of precise definitions for aphasiological terminology & recommendation that aphasiological research employ a 5-phase outcome research model are discussed; in addition, Birch & Davis Associates's (1997) scale for assessing the quality of evidence is deemed another important methods for organizing outcomes data. Existing research that has used meta-analytical approaches, randomized controlled trials, self-selected methods, & comparison of parallel group designs to assess the efficacy of language rehabilitation in aphasia is reviewed. Although language rehabilitation does produce measurable gains in aphasic individuals, it is concluded that additional research is needed to determine whether language rehabilitation therapy is cost effective. 46 References. J. W. Parker JF - Aphasiology AU - Wertz, Robert T AU - Irwin, William H AD - VA Medical Center, Nashville, TN robert.wertz@med.va.gov Y1 - 2001/03// PY - 2001 DA - Mar 2001 SP - 231 EP - 247 VL - 15 IS - 3 SN - 0268-7038, 0268-7038 KW - *Language Therapy (44400) KW - *Linguists (48250) KW - *Aphasia (03400) KW - *History of Linguistics (32150) KW - article KW - 6812: special education; language therapy KW - 4810: history of linguistics; history of linguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85346114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Darley+and+the+Efficacy+of+Language+Rehabilitation+in+Aphasia&rft.au=Wertz%2C+Robert+T%3BIrwin%2C+William+H&rft.aulast=Wertz&rft.aufirst=Robert&rft.date=2001-03-01&rft.volume=15&rft.issue=3&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2003-10-01 N1 - Last updated - 2014-06-17 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - *Language Therapy (44400); *Aphasia (03400); *History of Linguistics (32150); *Linguists (48250) ER - TY - JOUR T1 - Type and Severity of Aphasia during the First Seven Months Poststroke AN - 85341648; llba-200107372 AB - Empirical, prognostic evidence of the influence of type on severity of & recovery from aphasia is limited. Forty-one treated adults with aphasia were administered four standardized language impairment & communication activity limitation tests at approximately 1 month poststroke. Tests were readministered 3 & 6 months later to determine whether change in severity &/or type of aphasia had occurred. On all tests, initial severity differed significantly among types. Rate of recovery also differed among types: Some types demonstrated significant amounts of improvement, but others did not, &, while language impairment outcome at 7 months poststroke differed significantly among types, the results varied by test. Finally, more than one third of the patients changed type during the 6-month period. Percentages & patterns of change varied by time, poststroke, of classification. 6 Tables, 4 Figures, 54 References. Adapted from the source document JF - Journal of Medical Speech-Language Pathology AU - Ross, Katherine B AU - Wertz, Robert T AD - Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ katherine.ross3@med.va.gov Y1 - 2001/03// PY - 2001 DA - Mar 2001 SP - 31 EP - 53 VL - 9 IS - 1 SN - 1065-1438, 1065-1438 KW - *Prognostic Tests (68150) KW - *Aphasia (03400) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85341648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Speech-Language+Pathology&rft.atitle=Type+and+Severity+of+Aphasia+during+the+First+Seven+Months+Poststroke&rft.au=Ross%2C+Katherine+B%3BWertz%2C+Robert+T&rft.aulast=Ross&rft.aufirst=Katherine&rft.date=2001-03-01&rft.volume=9&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Speech-Language+Pathology&rft.issn=10651438&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2003-10-01 N1 - Last updated - 2014-06-17 N1 - CODEN - JSLPEP N1 - SubjectsTermNotLitGenreText - *Aphasia (03400); *Prognostic Tests (68150) ER - TY - JOUR T1 - Recent insights into the role of tumor necrosis factor in the failing heart. AN - 77061494; 11309526 AB - Recent studies have identified the importance of biologically active molecules such as neurohormones in disease progression in heart failure. More recently it has become apparent that in addition to neurohormones, another portfolio of biologically active molecules termed cytokines, are also expressed in the setting of heart failure. This article will review recent clinical and experimental material which suggests that tumor necrosis factor (TNF), a pro-inflammatory cytokine, may contribute to disease progression in heart failure by virtue of the direct toxic effects that this molecule exerts on the heart and circulation. JF - Heart failure reviews AU - Mann, D L AD - Winters Center for Heart Failure Research, Cardiology Section, Department of Medicine, Veterans Administration Medical Center and Baylor College of Medicine, 2002 Holcombe Blvd., Houston TX 77030, USA. dmann@bcm.tmc.edu Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 71 EP - 80 VL - 6 IS - 2 SN - 1382-4147, 1382-4147 KW - Tumor Necrosis Factor-alpha KW - 0 KW - Index Medicus KW - Humans KW - Disease Progression KW - Gene Expression Regulation KW - Heart Failure -- genetics KW - Heart Failure -- metabolism KW - Tumor Necrosis Factor-alpha -- metabolism KW - Tumor Necrosis Factor-alpha -- genetics KW - Heart Failure -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77061494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Heart+failure+reviews&rft.atitle=Recent+insights+into+the+role+of+tumor+necrosis+factor+in+the+failing+heart.&rft.au=Mann%2C+D+L&rft.aulast=Mann&rft.aufirst=D&rft.date=2001-03-01&rft.volume=6&rft.issue=2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Heart+failure+reviews&rft.issn=13824147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cardiovascular and renal effects of COX-2-specific inhibitors: recent insights and evolving clinical implications. AN - 77058859; 11304661 JF - American journal of therapeutics AU - Epstein, M AD - Nephrology Section, University of Miami School of Medicine, Miami, FL 33125, USA. murray.epstein@med.va.gov PY - 2001 SP - 81 EP - 83 VL - 8 IS - 2 SN - 1075-2765, 1075-2765 KW - Cyclooxygenase Inhibitors KW - 0 KW - Lactones KW - Pyrazoles KW - Sulfonamides KW - Sulfones KW - rofecoxib KW - 0QTW8Z7MCR KW - Celecoxib KW - JCX84Q7J1L KW - Index Medicus KW - Arthritis, Rheumatoid -- drug therapy KW - Edema -- chemically induced KW - Hypertension -- chemically induced KW - Humans KW - Osteoarthritis -- drug therapy KW - Kidney Diseases -- chemically induced KW - Lactones -- adverse effects KW - Cyclooxygenase Inhibitors -- adverse effects KW - Sulfonamides -- adverse effects KW - Lactones -- administration & dosage KW - Cyclooxygenase Inhibitors -- administration & dosage KW - Kidney -- drug effects KW - Heart -- drug effects KW - Sulfonamides -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77058859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+therapeutics&rft.atitle=Cardiovascular+and+renal+effects+of+COX-2-specific+inhibitors%3A+recent+insights+and+evolving+clinical+implications.&rft.au=Epstein%2C+M&rft.aulast=Epstein&rft.aufirst=M&rft.date=2001-03-01&rft.volume=8&rft.issue=2&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=American+journal+of+therapeutics&rft.issn=10752765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-14 N1 - Date created - 2001-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Olanzapine-lnduced hyperglycemic nonketonic coma. AN - 76988064; 11261526 AB - To report a case of olanzapine-induced hyperglycemia leading to a hyperosmolar, hyperglycemic, nonketonic coma. A 51-year-old, 85.5-kg (ideal body weight 79.9 kg), white man presented to a Veterans Affairs hospital with a serum glucose concentration of 1596 mg/dL. Soon thereafter, he went into a hyperosmolar, hyperglycemic, nonketonic coma. Olanzapine therapy had been instituted less than six months prior to this event; approximately two months before this event, his blood glucose was 108 mg/dL. Eight days after stopping olanzapine, the glucose concentration returned to normal, and the patient no longer required insulin nor any other glucose-lowering agents. The insulin resistance caused by olanzapine is normally attributed to the weight gain associated with the drug. In this patient, it appears that olanzapine caused hyperglycemia by a mechanism other than weight gain. This case report and others from the literature suggest that olanzapine therapy may induce hyperglycemia in some patients. JF - The Annals of pharmacotherapy AU - Roefaro, J AU - Mukherjee, S M AD - Veterans Affairs Boston Healthcare System, MA 02130-4817, USA. roefaro.john@boston.va.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 300 EP - 302 VL - 35 IS - 3 SN - 1060-0280, 1060-0280 KW - Antipsychotic Agents KW - 0 KW - Blood Glucose KW - Benzodiazepines KW - 12794-10-4 KW - Pirenzepine KW - 3G0285N20N KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - Blood Glucose -- metabolism KW - Humans KW - Bipolar Disorder -- drug therapy KW - Middle Aged KW - Stress Disorders, Post-Traumatic -- drug therapy KW - Male KW - Hyperglycemic Hyperosmolar Nonketotic Coma -- blood KW - Pirenzepine -- analogs & derivatives KW - Antipsychotic Agents -- therapeutic use KW - Antipsychotic Agents -- adverse effects KW - Pirenzepine -- therapeutic use KW - Pirenzepine -- adverse effects KW - Hyperglycemic Hyperosmolar Nonketotic Coma -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76988064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Olanzapine-lnduced+hyperglycemic+nonketonic+coma.&rft.au=Roefaro%2C+J%3BMukherjee%2C+S+M&rft.aulast=Roefaro&rft.aufirst=J&rft.date=2001-03-01&rft.volume=35&rft.issue=3&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-21 N1 - Date created - 2001-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Octreotide potentiates PKC-dependent vasoconstrictors in portal-hypertensive and control rats. AN - 76977248; 11231951 AB - The effect of octreotide on vascular tone in the superior mesenteric artery (SMA) was studied in portal-hypertensive (portal vein-ligated) and sham-operated rats. In vitro-perfused SMA vascular beds were tested for the cumulative dose-response to octreotide at baseline conditions and after preconstriction with different vasoconstrictors (alpha1-agonist methoxamine, endothelin [ET-1], phorbol ester [PdBu], and potassium chloride [KCl]). Octreotide did not affect baseline perfusion pressures (without preconstriction). alpha1-Adrenergic-, ET-1-, and PdBu-, but not KCl-, induced vasoconstriction was significantly potentiated by octreotide. This effect was dose-dependent and not different in portal vein-ligated and sham rats. Amplification of alpha1-adrenergic vasoconstriction by octreotide was significantly enhanced by nitric oxide inhibition (N(W)-nitro-L-arginine, 10(-4) mol/L) as well as by removal of the endothelium, and was completely suppressed by inhibition of protein kinase C (calphostin C, 1 micromol/L), phospholipase A2 (quinacrine, 5 micromol/L), and cyclooxygenase (indomethacin, 20 micromol/L). Not directly, but in the presence of vasoconstrictors involving activation of protein kinase C, octreotide exerts a local vasoconstrictive effect on vascular smooth muscle of SMA. This potentiation is equipotent in portal vein-ligated and sham rats, immediate in onset, and mediated via phospholipase A2 and cyclooxygenase-derived prostanoids. This indicates that in preprandial conditions octreotide enhances the vasoconstrictive effect of dependent vasoconstrictors. JF - Gastroenterology AU - Wiest, R AU - Tsai, M H AU - Groszmann, R J AD - Hepatic Hemodynamic Laboratory, Veterans Administration Medical Center, West Haven, Connecticut 06516, USA. Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 975 EP - 983 VL - 120 IS - 4 SN - 0016-5085, 0016-5085 KW - Adrenergic alpha-Agonists KW - 0 KW - Endothelin-1 KW - Vasoconstrictor Agents KW - Nitric Oxide KW - 31C4KY9ESH KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Methoxamine KW - HUQ1KC1YLI KW - Octreotide KW - RWM8CCW8GP KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Methoxamine -- pharmacology KW - Reference Values KW - Adrenergic alpha-Agonists -- pharmacology KW - Dose-Response Relationship, Drug KW - Nitric Oxide -- physiology KW - Endothelium, Vascular -- physiopathology KW - Phorbol 12,13-Dibutyrate -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Drug Synergism KW - Endothelin-1 -- pharmacology KW - Male KW - Vasoconstrictor Agents -- pharmacology KW - Octreotide -- pharmacology KW - Protein Kinase C -- physiology KW - Hypertension, Portal -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76977248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Octreotide+potentiates+PKC-dependent+vasoconstrictors+in+portal-hypertensive+and+control+rats.&rft.au=Wiest%2C+R%3BTsai%2C+M+H%3BGroszmann%2C+R+J&rft.aulast=Wiest&rft.aufirst=R&rft.date=2001-03-01&rft.volume=120&rft.issue=4&rft.spage=975&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-19 N1 - Date created - 2001-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Biliary cyst fluid from common bile duct-ligated rats stimulates endothelial nitric oxide synthase in pulmonary artery endothelial cells: a potential role in hepatopulmonary syndrome. AN - 76968580; 11230754 AB - The hepatopulmonary syndrome (HPS) results from pulmonary microvascular dilatation in cirrhosis and is associated with increased pulmonary endothelial nitric oxide synthase (eNOS) levels. In the common bile duct ligation (CBDL) model, endothelin-1 (ET-1) released from the liver contributes to the rise in pulmonary eNOS and intrapulmonary vasodilatation. Whether substances, including ET-1, are found in the biliary tree and selectively enter the circulation after CBDL to influence the pulmonary vasculature is unknown. We assessed if control bile and fluid obtained from the obstructed biliary tree in CBDL animals contains ET-1 and alters eNOS expression and activity in bovine pulmonary artery endothelial cells (BPAECs). Control bile and biliary cyst fluid contained concentrations of ET-1 25- to 42-fold normal plasma levels, and hepatic venous concentrations of ET-1 were selectively increased after CBDL. Biliary cyst fluid caused a dose-dependent induction of eNOS messenger RNA (mRNA) (1.9-fold control), protein (2.5-fold control), and enzyme activity (2.2-fold control) maximal at a 1:10 dilution. The increases were associated with enhanced nitric oxide (NO) production (3.1-fold control) and were inhibitable with an ET(B) receptor antagonist. Bile from sham and portal vein-ligated animals did not increase eNOS expression and at dilutions of 1:100 and 1:10 caused cell toxicity. These results show that bile and biliary cyst fluid contain high concentrations of ET-1 that are specifically increased in hepatic venous blood after CBDL. Biliary cyst fluid increases eNOS expression and activity in an ET(B) receptor-dependent manner in BPAECs. The findings suggest a novel mechanism for the susceptibility of CBDL animals to the HPS. JF - Hepatology (Baltimore, Md.) AU - Liu, L AU - Zhang, M AU - Luo, B AU - Abrams, G A AU - Fallon, M B AD - Department of Internal Medicine, Liver Center, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, AL, USA. Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 722 EP - 727 VL - 33 IS - 3 SN - 0270-9139, 0270-9139 KW - Endothelin-1 KW - 0 KW - Nitrites KW - RNA, Messenger KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Nitric Oxide Synthase Type III KW - Nos3 protein, rat KW - Index Medicus KW - Animals KW - Nitrites -- metabolism KW - Hepatopulmonary Syndrome -- physiopathology KW - Rats KW - Endothelin-1 -- physiology KW - Rats, Sprague-Dawley KW - Cattle KW - RNA, Messenger -- metabolism KW - Cells, Cultured KW - Common Bile Duct KW - Ligation KW - Male KW - Body Fluids -- physiology KW - Endothelium, Vascular -- enzymology KW - Endothelium, Vascular -- cytology KW - Bile Duct Diseases -- metabolism KW - Nitric Oxide Synthase -- genetics KW - Cysts -- metabolism KW - Pulmonary Artery -- cytology KW - Nitric Oxide Synthase -- metabolism KW - Pulmonary Artery -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76968580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Biliary+cyst+fluid+from+common+bile+duct-ligated+rats+stimulates+endothelial+nitric+oxide+synthase+in+pulmonary+artery+endothelial+cells%3A+a+potential+role+in+hepatopulmonary+syndrome.&rft.au=Liu%2C+L%3BZhang%2C+M%3BLuo%2C+B%3BAbrams%2C+G+A%3BFallon%2C+M+B&rft.aulast=Liu&rft.aufirst=L&rft.date=2001-03-01&rft.volume=33&rft.issue=3&rft.spage=722&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-12 N1 - Date created - 2001-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of TNK with wild-type tissue plasminogen activator in a rabbit embolic stroke model. AN - 76957971; 11239197 AB - Tissue plasminogen activator (tPA) is an effective treatment for stroke, but its utility is limited by fear of cerebral hemorrhage. Tenecteplase (TNK), a genetically modified form of wild-type tPA, exhibits a longer biological half-life and greater fibrin specificity, features that could lead to fewer cerebral hemorrhages than wild-type tPA in stroke patients. We injected radiolabeled blood clots into the cerebral circulation of New Zealand White rabbits. One hour later, we administered tPA (n=57), 0.6 mg/kg TNK (n=43), 1.5 mg/kg TNK (n=27), or vehicle control (n=37). A blinded observer examined the brains for macroscopic hemorrhage using a semiquantitative score. We estimated thrombolysis by assessing the amount of radiolabel remaining in the cerebral vessels postmortem. Both wild-type tPA and TNK caused thrombolysis in most subjects. Hemorrhage was detected in 26% (6/23) of the control group, 66% (27/41) of the wild-type tPA group, 55% (16/29) in the 0.6-mg/kg TNK group, and 53% (9/17) in the 1.5-mg/kg TNK group (P:<0.05, chi(2) test). The tPA group was statistically significantly different from the control group, but the TNK and tPA groups did not differ from each other. Neither TNK nor tPA affected the size of the hemorrhages. TNK shows comparable rates of recanalization compared with wild-type tPA in a model of embolic stroke. While tPA increases hemorrhage rate, the hemorrhage associated with TNK treatment is not statistically different compared with controls or the tPA group. These findings suggest that TNK shows promise as an alternative thrombolytic treatment for stroke, but we could not demonstrate improved safety compared with wild-type tPA. JF - Stroke AU - Chapman, D F AU - Lyden, P AU - Lapchak, P A AU - Nunez, S AU - Thibodeaux, H AU - Zivin, J AD - Department of Neurosciences, University of California at San Diego School of Medicine, and Department of Neurology, Veterans Administration Medical Center, San Diego, CA, USA. Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 748 EP - 752 VL - 32 IS - 3 KW - TNK-tissue plasminogen activator KW - EC 3.4.21.68 KW - Tissue Plasminogen Activator KW - Index Medicus KW - Animals KW - Cerebral Hemorrhage -- prevention & control KW - Treatment Outcome KW - Disease Models, Animal KW - Cerebral Hemorrhage -- pathology KW - Rabbits KW - Cerebral Hemorrhage -- etiology KW - Thrombolytic Therapy -- adverse effects KW - Intracranial Embolism -- complications KW - Stroke -- drug therapy KW - Stroke -- complications KW - Tissue Plasminogen Activator -- therapeutic use KW - Stroke -- pathology KW - Tissue Plasminogen Activator -- adverse effects KW - Intracranial Embolism -- pathology KW - Intracranial Embolism -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76957971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stroke&rft.atitle=Comparison+of+TNK+with+wild-type+tissue+plasminogen+activator+in+a+rabbit+embolic+stroke+model.&rft.au=Chapman%2C+D+F%3BLyden%2C+P%3BLapchak%2C+P+A%3BNunez%2C+S%3BThibodeaux%2C+H%3BZivin%2C+J&rft.aulast=Chapman&rft.aufirst=D&rft.date=2001-03-01&rft.volume=32&rft.issue=3&rft.spage=748&rft.isbn=&rft.btitle=&rft.title=Stroke&rft.issn=1524-4628&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-26 N1 - Date created - 2001-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thiamine treatment of chronic hepatitis B infection AN - 759322085; 13788146 AB - OBJECTIVE:Chronic hepatitis B is an international health concern that causes cirrhosis, hepatocellular carcinoma, liver failure, and death. Current treatment options are expensive and associated with side effects; however, indirect evidence suggests a relationship between relative thiamine deficiency and chronic hepatitis B infection. METHODS:The authors present three case studies wherein multiple crossovers of daily thiamine administration were used to evaluate a hypothesized association between thiamine treatment and aminotransferase levels. RESULTS:In each case study, thiamine administration was associated with reduction in aminotransferase levels and the fall of HBV DNA to undetectable levels. Analyses by t test demonstrated a statistically significant reduction in aminotransferase levels in all three cases. CONCLUSIONS:The relationship between thiamine administration and chronic hepatitis B infection warrants further study. If proven effective in reducing liver damage or inducing remission of the hepatitis B virus in larger trials, thiamine will offer obvious advantages over the current treatments for chronic viral hepatitis B infection.The American Journal of Gastroenterology (2001) 96, 864-868; doi:10.1111/j.1572-0241.2001.03635.x JF - American Journal of Gastroenterology AU - Wallace, Amy Elizabeth AU - Weeks, William Brinson AD - [1] 1 Department of Psychiatry, Dartmouth Medical School, Hanover, New Hampshire, USA [2] 3 Veterans Administration Medical Center, White River Junction, Vermont, USA Y1 - 2001/03// PY - 2001 DA - Mar 2001 SP - 864 EP - 868 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 96 IS - 3 SN - 0002-9270, 0002-9270 KW - Virology & AIDS Abstracts; Toxicology Abstracts KW - Liver diseases KW - Cirrhosis KW - Hepatitis B virus KW - Thiamine KW - Statistical analysis KW - Remission KW - Gastroenterology KW - Chronic infection KW - Hepatitis B KW - DNA KW - Side effects KW - Hepatocellular carcinoma KW - X 24310:Pharmaceuticals KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759322085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Gastroenterology&rft.atitle=Thiamine+treatment+of+chronic+hepatitis+B+infection&rft.au=Wallace%2C+Amy+Elizabeth%3BWeeks%2C+William+Brinson&rft.aulast=Wallace&rft.aufirst=Amy&rft.date=2001-03-01&rft.volume=96&rft.issue=3&rft.spage=864&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/10.1111%2Fj.1572-0241.2001.03635.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Cirrhosis; Liver diseases; Chronic infection; DNA; Statistical analysis; Hepatitis B; Thiamine; Remission; Side effects; Hepatocellular carcinoma; Gastroenterology; Hepatitis B virus DO - http://dx.doi.org/10.1111/j.1572-0241.2001.03635.x ER - TY - JOUR T1 - Site-directed mutagenesis of cation coordinating residues in the gastric H,K-ATPase. AN - 70859024; 11368180 AB - Site-mutations were introduced into putative cation binding site 1 of the H,K-ATPase at glu-797, thr-825, and glu-938. The side chain oxygen of each was not essential but the mutations produced different activation and inhibition kinetics. Site mutations thr-825 (ala, leu) and glu-938 (ala, gln) modestly decreased the apparent affinity to K+, while glu-797 (gln) was equivalent to wild type. As expected of competitive inhibition, mutations of thr-825 and glu-938 that decreased the apparent affinity for K+ also increased the apparent affinity for SCH28080. This is consistent with the participation of thr-825 and glu-938 in a cation binding domain. The sidechain geometry, but not the sidechain charge of glu-797, is essential to ATPase function as the site mutant glu-797 (gly) inactivated the H,K-ATPase, while glu-797 (gln) was active but the apparent affinity to SCH 28080 was decreased by four-fold. Lys-793, a unique residue of the H,K-ATPase, was essential for ATPase function. Since this residue is adjacent to site 1, the result suggests that charge pairing between lys-793 and residues at or near this site may be essential to ATPase function. JF - Archives of biochemistry and biophysics AU - Rulli, S J AU - Louneva, N M AU - Skripnikova, E V AU - Rabon, E C AD - Department of Physiology, Tulane University Medical Center and Veterans Administration Center, New Orleans, Louisiana 70112, USA. Y1 - 2001/03/01/ PY - 2001 DA - 2001 Mar 01 SP - 27 EP - 34 VL - 387 IS - 1 SN - 0003-9861, 0003-9861 KW - Cations KW - 0 KW - Membrane Proteins KW - Recombinant Proteins KW - H(+)-K(+)-Exchanging ATPase KW - EC 3.6.3.10 KW - Calcium-Transporting ATPases KW - EC 3.6.3.8 KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Animals KW - Calcium-Transporting ATPases -- chemistry KW - Rabbits KW - Membrane Proteins -- genetics KW - Proto-Oncogenes KW - Potassium -- metabolism KW - Cations -- metabolism KW - Mutagenesis, Site-Directed KW - Recombinant Proteins -- metabolism KW - Models, Chemical KW - Binding Sites -- genetics KW - Recombinant Proteins -- chemistry KW - Calcium-Transporting ATPases -- metabolism KW - H(+)-K(+)-Exchanging ATPase -- metabolism KW - H(+)-K(+)-Exchanging ATPase -- chemistry KW - H(+)-K(+)-Exchanging ATPase -- genetics KW - Stomach -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70859024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+biochemistry+and+biophysics&rft.atitle=Site-directed+mutagenesis+of+cation+coordinating+residues+in+the+gastric+H%2CK-ATPase.&rft.au=Rulli%2C+S+J%3BLouneva%2C+N+M%3BSkripnikova%2C+E+V%3BRabon%2C+E+C&rft.aulast=Rulli&rft.aufirst=S&rft.date=2001-03-01&rft.volume=387&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Archives+of+biochemistry+and+biophysics&rft.issn=00039861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-14 N1 - Date created - 2001-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intravenous cocaine increases plasma epinephrine and norepinephrine in humans. AN - 70779743; 11325399 AB - Cocaine has been shown to activate the sympathoadrenal system in both animal and human studies. Controlled human studies have found inconclusive results regarding whether acute cocaine treatment elevates plasma epinephrine and norepinephrine concentrations. The purpose of this study was to investigate whether commonly abused doses of cocaine increase plasma epinephrine and norepinephrine concentrations in humans, in a double-blind, placebo-controlled study. Five male cocaine users were given an intravenous injection of 0.46 mg/kg dose of cocaine or placebo, on two consecutive days. Plasma epinephrine and norepinephrine concentrations were significantly increased in response to cocaine injection compared to placebo. Peak plasma epinephrine and norepinephrine concentrations were reached 3 and 12 min after cocaine injection, respectively. While changes in epinephrine levels following cocaine were correlated with systolic blood pressure and heart rate changes, changes in plasma norepinephrine were correlated with diastolic blood pressure and heart rate changes following cocaine administration. These results suggest that plasma epinephrine and norepinephrine can be used as a measure for cocaine induced sympathoadrenal system activation. JF - Pharmacology, biochemistry, and behavior AU - Sofuoglu, M AU - Nelson, D AU - Babb, D A AU - Hatsukami, D K AD - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA. mehmet.sofuoglu2@med.va.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 455 EP - 459 VL - 68 IS - 3 SN - 0091-3057, 0091-3057 KW - Dopamine Uptake Inhibitors KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Norepinephrine KW - X4W3ENH1CV KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - Heart Rate -- drug effects KW - Injections, Intravenous KW - Humans KW - Adult KW - Cocaine-Related Disorders -- physiopathology KW - Cocaine-Related Disorders -- blood KW - Blood Pressure -- drug effects KW - Male KW - Norepinephrine -- blood KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Cocaine -- pharmacology KW - Epinephrine -- blood KW - Cocaine -- administration & dosage KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70779743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Intravenous+cocaine+increases+plasma+epinephrine+and+norepinephrine+in+humans.&rft.au=Sofuoglu%2C+M%3BNelson%2C+D%3BBabb%2C+D+A%3BHatsukami%2C+D+K&rft.aulast=Sofuoglu&rft.aufirst=M&rft.date=2001-03-01&rft.volume=68&rft.issue=3&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-19 N1 - Date created - 2001-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Linezolid: an oxazolidinone antimicrobial agent. AN - 70777574; 11318073 AB - Linezolid is the first oxazolidinone anti-infective agent marketed in the United States. It is indicated for the treatment of nosocomial pneumonia, complicated skin and skin-structure infections caused by methicillin-sensitive or methicillin-resistant Staphylococcus aureus and other susceptible organisms, and vancomycin-resistant Enterococcus faecium infections. It also is indicated for the treatment of uncomplicated skin and skin-structure infections caused by methicillin-sensitive S. aureus or Streptococcus pyogenes, and community-acquired pneumonia caused by penicillin-sensitive Streptococcus pneumoniae. This article reviews the pharmacologic properties and clinical usefulness of linezolid. Using the terms linezolid, PNU-100766, and oxazolidinone, we performed a literature search of the following databases: MEDLINE (1966 to September 2000), HealthSTAR (1993 to September 2000), Iowa Drug Information Service (1966 to September 2000), International Pharmaceutical Abstracts (1970 to September 2000), PharmaProjects (January 2000 version), and meeting abstracts of the Infectious Diseases Society of America and the Interscience Conference on Antimicrobial Agents and Chemotherapy (1996 to 2000). Linezolid has a unique structure and mechanism of action, which targets protein synthesis at an exceedingly early stage. Consequently, cross-resistance with other commercially available antimicrobial agents is unlikely. It is primarily effective against gram-positive bacteria. To date, resistance to linezolid has been reported in patients infected with enterococci. The pharmacokinetic parameters of linezolid in adults are not altered by hepatic or renal function, age, or sex to an extent requiring dose adjustment. Linezolid is metabolized via morpholine ring oxidation, which is independent of the cytochrome P450 (CYP450) enzyme system; as a result, linezolid is unlikely to interact with medications that stimulate or inhibit CYP450 enzymes. Compassionate-use trials and other clinical studies involving mainly adult hospitalized patients with gram-positive infections have shown that linezolid administered intravenously or orally is effective in a variety of nosocomial and community-acquired infections, including those caused by resistant gram-positive organisms. Reported adverse effects include thrombocytopenia. diarrhea, headache, nausea, vomiting, insomnia, constipation, rash, and dizziness. Preliminary pharmacoeconomic data indicate that a significantly higher percentage of patients receiving linezolid therapy versus comparator could be discharged from the hospital by day 7 (P = 0.005). Linezolid appears to be effective while maintaining an acceptable tolerability profile. Due to the risk of bacterial resistance, linezolid should be reserved for the treatment of documented serious vancomycin-resistant enterococcal infections. JF - Clinical therapeutics AU - Fung, H B AU - Kirschenbaum, H L AU - Ojofeitimi, B O AD - Critical Care Center, Veterans Affairs Medical Center, Bronx, New York 10468, USA. horatio.fung@med.va.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 356 EP - 391 VL - 23 IS - 3 SN - 0149-2918, 0149-2918 KW - Acetamides KW - 0 KW - Anti-Bacterial Agents KW - Oxazolidinones KW - Linezolid KW - ISQ9I6J12J KW - Index Medicus KW - Soft Tissue Infections -- drug therapy KW - Animals KW - Drug Interactions KW - Pneumonia, Bacterial -- drug therapy KW - Humans KW - Cross Infection -- drug therapy KW - Vancomycin Resistance KW - Anti-Bacterial Agents -- therapeutic use KW - Acetamides -- pharmacology KW - Oxazolidinones -- therapeutic use KW - Oxazolidinones -- pharmacology KW - Acetamides -- therapeutic use KW - Acetamides -- pharmacokinetics KW - Oxazolidinones -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70777574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+therapeutics&rft.atitle=Linezolid%3A+an+oxazolidinone+antimicrobial+agent.&rft.au=Fung%2C+H+B%3BKirschenbaum%2C+H+L%3BOjofeitimi%2C+B+O&rft.aulast=Fung&rft.aufirst=H&rft.date=2001-03-01&rft.volume=23&rft.issue=3&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=Clinical+therapeutics&rft.issn=01492918&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-30 N1 - Date created - 2001-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Augmentation of Apoptosis and Interferon- gamma Production at Sites of Active Mycobacterium tuberculosis Infection in Human Tuberculosis AN - 18075268; 5149676 AB - Pleural tuberculosis (TB) was employed as a model to study T cell apoptosis at sites of active Mycobacterium tuberculosis (MTB) infection in human immunodeficiency virus (HIV)-coinfected (HIV/TB) patients and patients infected with TB alone. Apoptosis in blood and in pleural fluid mononuclear cells and cytokine immunoreactivities in plasma and in pleural fluid were evaluated. T cells were expanded at the site of MTB infection, irrespective of HIV status. Apoptosis of CD4 and non-CD4 T cells in the pleural space occurred in both HIV/TB and TB. Interferon (IFN)- gamma levels were increased in pleural fluid, compared with plasma. Spontaneous apoptosis correlated with specific loss of MTB-reactive, IFN- gamma -producing pleural T cells. Immunoreactivities of molecules potentially involved in apoptosis, such as tumor necrosis factor- alpha , Fas-ligand, and Fas, were increased in pleural fluid, compared with plasma. These data suggest that continued exposure of immunoreactive cells to MTB at sites of infection may initiate a vicious cycle in which immune activation and loss of antigen-responsive T cells occur concomitantly, thus favoring persistence of MTB infection. JF - Journal of Infectious Diseases AU - Hirsch, C S AU - Toossi, Z AU - Johnson, J L AU - Luzze, H AU - Ntambi, L AU - Peters, P AU - McHugh, M AU - Okwera, A AU - Joloba, M AU - Mugyenyi, P AU - Mugerwa, R D AU - Terebuh, P AU - Ellner, J J AD - Case Western Reserve University, University Hospitals of Cleveland, and Veterans Administration Medical Center, Cleveland, Ohio, USA Y1 - 2001/03/01/ PY - 2001 DA - 2001 Mar 01 SP - 779 EP - 788 VL - 183 IS - 5 SN - 0022-1899, 0022-1899 KW - man KW - HIV KW - CD4 antigen KW - gamma -Interferon KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - g-Interferon KW - Acquired immune deficiency syndrome KW - Apoptosis KW - ^g-Interferon KW - Human immunodeficiency virus KW - Lymphocytes T KW - Tuberculosis KW - Mycobacterium tuberculosis KW - F 06773:Interferons KW - F 06801:Bacteria KW - F 06737:Apoptosis KW - J 02833:Immune response and immune mechanisms KW - F 06756:Function KW - V 22003:AIDS: Immunological aspects KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18075268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Augmentation+of+Apoptosis+and+Interferon-+gamma+Production+at+Sites+of+Active+Mycobacterium+tuberculosis+Infection+in+Human+Tuberculosis&rft.au=Hirsch%2C+C+S%3BToossi%2C+Z%3BJohnson%2C+J+L%3BLuzze%2C+H%3BNtambi%2C+L%3BPeters%2C+P%3BMcHugh%2C+M%3BOkwera%2C+A%3BJoloba%2C+M%3BMugyenyi%2C+P%3BMugerwa%2C+R+D%3BTerebuh%2C+P%3BEllner%2C+J+J&rft.aulast=Hirsch&rft.aufirst=C&rft.date=2001-03-01&rft.volume=183&rft.issue=5&rft.spage=779&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus; Mycobacterium tuberculosis; Tuberculosis; Apoptosis; Lymphocytes T; Acquired immune deficiency syndrome; ^g-Interferon ER - TY - JOUR T1 - Mycobacterium tuberculosis Phagosomes Exhibit Altered Calmodulin-Dependent Signal Transduction: Contribution to Inhibition of Phagosome-Lysosome Fusion and Intracellular Survival in Human Macrophages AN - 17802483; 4849343 AB - Mycobacterium tuberculosis successfully parasitizes macrophages by disrupting the maturation of its phagosome, creating an intracellular compartment with endosomal rather than lysosomal characteristics. We have recently demonstrated that live M. tuberculosis infect human macrophages in the absence of an increase in cytosolic Ca super(2+) ([Ca super(2+)] sub(c)), which correlates with inhibition of phagosome-lysosome fusion and intracellular viability. In contrast, killed M. tuberculosis induces an elevation in [Ca super(2+)] sub(c) that is coupled to phagosome-lysosome fusion. We tested the hypothesis that defective activation of the Ca super(2+)-dependent effector proteins calmodulin (CaM) and CaM-dependent protein kinase II (CaMKII) contributes to the intracellular pathogenesis of tuberculosis. Phagosomes containing live M. tuberculosis exhibited decreased levels of CaM and the activated form of CaMKII compared with phagosomes encompassing killed tubercle bacilli. Furthermore, ionophore-induced elevations in [Ca super(2+)] sub(c) resulted in recruitment of CaM and activation of CaMKII on phagosomes containing live M. tuberculosis. Specific inhibitors of CaM or CaMKII blocked Ca super(2+) ionophore-induced phagosomal maturation and enhanced the bacilli's intracellular viability. These results demonstrate a novel role for CaM and CaMKII in the regulation of phagosome-lysosome fusion and suggest that defective activation of these Ca super(2+)-activated signaling components contributes to the successful parasitism of human macrophages by M. tuberculosis. JF - Journal of Immunology AU - Malik, Z A AU - Iyer, S S AU - Kusner, D J AD - Inflammation Program, Graduate Program in Immunology, and Department of Internal Medicine, University of Iowa and Veterans Administration Medical Center, Iowa City, IA 52242 Y1 - 2001/03/01/ PY - 2001 DA - 2001 Mar 01 SP - 3392 EP - 3401 VL - 166 IS - 5 SN - 0022-1767, 0022-1767 KW - immunology KW - Mycobacterium tuberculosis KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Calcium KW - Ca@@u2+@/calmodulin-dependent protein kinase II KW - Phagosomes KW - Calmodulin KW - Tuberculosis KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17802483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Mycobacterium+tuberculosis+Phagosomes+Exhibit+Altered+Calmodulin-Dependent+Signal+Transduction%3A+Contribution+to+Inhibition+of+Phagosome-Lysosome+Fusion+and+Intracellular+Survival+in+Human+Macrophages&rft.au=Malik%2C+Z+A%3BIyer%2C+S+S%3BKusner%2C+D+J&rft.aulast=Malik&rft.aufirst=Z&rft.date=2001-03-01&rft.volume=166&rft.issue=5&rft.spage=3392&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Phagosomes; Macrophages; Calcium; Calmodulin; Tuberculosis; Ca@@u2+@/calmodulin-dependent protein kinase II ER - TY - JOUR T1 - Results of targeted anti-tumor necrosis factor therapy with etanercept (ENBREL) in patients with advanced heart failure. AN - 70657048; 11222463 AB - Previously, we showed that tumor necrosis factor (TNF) antagonism with etanercept, a soluble TNF receptor, was well tolerated and that it suppressed circulating levels of biologically active TNF for 14 days in patients with moderate heart failure. However, the effects of sustained TNF antagonism in heart failure are not known. We conducted a randomized, double-blind, placebo-controlled, multidose trial of etanercept in 47 patients with NYHA class III to IV heart failure. Patients were treated with biweekly subcutaneous injections of etanercept 5 mg/m(2) (n=16) or 12 mg/m(2) (n=15) or with placebo (n=16) for 3 months. Doses of 5 and 12 mg/m(2) etanercept were safe and well tolerated for 3 months. Treatment with etanercept led to a significant dose-dependent improvement in left ventricular (LV) ejection fraction and LV remodeling, and there was a trend toward an improvement in patient functional status, as determined by clinical composite score. Treatment with etanercept for 3 months was safe and well-tolerated in patients with advanced heart failure, and it resulted in a significant dose-dependent improvement in LV structure and function and a trend toward improvement in patient functional status. JF - Circulation AU - Bozkurt, B AU - Torre-Amione, G AU - Warren, M S AU - Whitmore, J AU - Soran, O Z AU - Feldman, A M AU - Mann, D L AD - Winters Center For Heart Failure Research, Department of Medicine, Veterans Administration Medical Center, Houston, TX 77030, USA. Y1 - 2001/02/27/ PY - 2001 DA - 2001 Feb 27 SP - 1044 EP - 1047 VL - 103 IS - 8 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Immunoglobulin G KW - Receptors, Tumor Necrosis Factor KW - Tumor Necrosis Factor-alpha KW - Etanercept KW - OP401G7OJC KW - Index Medicus KW - Ventricular Function, Left -- drug effects KW - Double-Blind Method KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Humans KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Cohort Studies KW - Treatment Outcome KW - Myocardial Contraction -- drug effects KW - Middle Aged KW - Male KW - Female KW - Heart Diseases -- drug therapy KW - Immunoglobulin G -- adverse effects KW - Receptors, Tumor Necrosis Factor -- therapeutic use KW - Tumor Necrosis Factor-alpha -- antagonists & inhibitors KW - Tumor Necrosis Factor-alpha -- metabolism KW - Immunoglobulin G -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70657048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation&rft.atitle=Results+of+targeted+anti-tumor+necrosis+factor+therapy+with+etanercept+%28ENBREL%29+in+patients+with+advanced+heart+failure.&rft.au=Bozkurt%2C+B%3BTorre-Amione%2C+G%3BWarren%2C+M+S%3BWhitmore%2C+J%3BSoran%2C+O+Z%3BFeldman%2C+A+M%3BMann%2C+D+L&rft.aulast=Bozkurt&rft.aufirst=B&rft.date=2001-02-27&rft.volume=103&rft.issue=8&rft.spage=1044&rft.isbn=&rft.btitle=&rft.title=Circulation&rft.issn=1524-4539&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-14 N1 - Date created - 2001-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Construction of Acetate Auxotrophs of Neisseria meningitidis to Study Host-Meningococcal Endotoxin Interactions AN - 17806208; 4844949 AB - To facilitate studies of the molecular determinants of host-meningococcal lipooligosaccharide (endotoxin) interactions at patho-physiologically relevant endotoxin concentrations (i.e. <=10 ng/ml), we have generated acetate auxotrophs NMBACE1 from encapsulated Neisseria meningitidis (serogroup B, strain NMB) and NMBACE2 from an isogenic bacterial mutant lacking the polysialic acid capsule. Growth of the auxotrophs in medium containing [ super(14)C]acetate yielded super(14)C-lipooligosaccharides containing similar to 600 cpm/ng. Gel sieving resolved super( 14)C-lipooligosaccharide-containing aggregates with an estimated molecular mass of greater than or equal to 20 x 10 super(6) Da (peak A) and similar to 1 x 10 super(6) Da (peak B) from both strains. Lipooligosaccharides in peaks A and B had the same fatty acid composition and SDS-polyacrylamide gel electrophoresis profile. super(14)C-Labeled capsule copurified with super(14)C-lipooligosaccharides in peak B from NMBACE1, whereas the other aggregates contained only super(14)C-lipooligosaccharide. For all aggregates, lipopolysaccharide-binding protein and soluble CD14-induced delivery of lipooligosaccharides to endothelial cells and cell activation correlated with disaggregation of lipooligosaccharides. These processes were inhibited by the presence of capsule but unaffected by the size of the aggregates. In contrast, endotoxin activation of cells containing membrane CD14 was unaffected by capsule but diminished when endotoxin was presented in larger aggregates. These findings demonstrate that the physical presentation of lipooligosaccharide, including possible interactions with capsule, affect the ability of meningococcal endotoxin to interact with and activate specific host targets. JF - Journal of Biological Chemistry AU - Giardina, P C AU - Gioannini, T AU - Buscher, BA AU - Zaleski, A AU - Zheng, D S AU - Stoll, L AU - Teghanemt, A AU - Apicella, MA AU - Weiss, J AD - Departments of Microbiology, Biochemistry, and Medicine, Division of Infectious Diseases, The Inflammation Program, University of Iowa and Veterans' Administration Medical Center, Iowa City, Iowa 52242, jerrold-weiss@uiowa.edu Y1 - 2001/02/23/ PY - 2001 DA - 2001 Feb 23 SP - 5883 EP - 5891 VL - 276 IS - 8 SN - 0021-9258, 0021-9258 KW - lipooligosaccharides KW - Microbiology Abstracts B: Bacteriology KW - Endotoxins KW - Auxotrophs KW - Neisseria meningitidis KW - Acetic acid KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17806208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Construction+of+Acetate+Auxotrophs+of+Neisseria+meningitidis+to+Study+Host-Meningococcal+Endotoxin+Interactions&rft.au=Giardina%2C+P+C%3BGioannini%2C+T%3BBuscher%2C+BA%3BZaleski%2C+A%3BZheng%2C+D+S%3BStoll%2C+L%3BTeghanemt%2C+A%3BApicella%2C+MA%3BWeiss%2C+J&rft.aulast=Giardina&rft.aufirst=P&rft.date=2001-02-23&rft.volume=276&rft.issue=8&rft.spage=5883&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Neisseria meningitidis; Endotoxins; Auxotrophs; Acetic acid ER - TY - JOUR T1 - Unexpected Similarity of Pulsed-Field Gel Electrophoresis Patterns of Unrelated Clinical Isolates of Legionella pneumophila, Serogrop 1 AN - 18075336; 5149699 AB - Phenotypic and genotypic methods identify subtypes of Legionella pneumophila, serogroup 1, and match patient and environmental isolates from suspected sources. The strength of this association is limited by the lack of information regarding the frequency and distribution of isolates belonging to various subtypes. In this study, 62 clinical isolates of L. pneumophila, serogroup 1, were subtyped by using pulsed-field gel electrophoresis (PFGE), to determine the distribution and degree of diversity of PFGE patterns among monoclonal antibody (MAb) subtypes. Unexpectedly, 8 of 21 MAb Philadelphia 1 isolates had a common PFGE pattern, and, among 12 MAb OLDA isolates, only 2 PFGE patterns were seen. Our hypothesis was that PFGE patterns were distributed randomly; however, statistical analysis showed that the distribution of subtypes was not random (Fisher's exact test 0.13; P > .05). In light of these results, researchers who do epidemiological investigations should use caution when interpreting the significance of matching PFGE patterns of L. pneumophila, serogroup 1. JF - Journal of Infectious Diseases AU - Drenning, S D AU - Stout, JE AU - Joly, J R AU - Yu, V L AD - Department of Medicine, University of Pittsburgh School of Medicine, and Veterans Administration Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA Y1 - 2001/02/15/ PY - 2001 DA - 2001 Feb 15 SP - 628 EP - 632 VL - 183 IS - 4 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology KW - Serological surveys KW - Legionella pneumophila KW - Genetic variance KW - Typing KW - Monoclonal antibodies KW - Nucleotide sequence KW - Pulsed-field gel electrophoresis KW - J 02710:Identification, taxonomy and typing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18075336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Unexpected+Similarity+of+Pulsed-Field+Gel+Electrophoresis+Patterns+of+Unrelated+Clinical+Isolates+of+Legionella+pneumophila%2C+Serogrop+1&rft.au=Drenning%2C+S+D%3BStout%2C+JE%3BJoly%2C+J+R%3BYu%2C+V+L&rft.aulast=Drenning&rft.aufirst=S&rft.date=2001-02-15&rft.volume=183&rft.issue=4&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Legionella pneumophila; Pulsed-field gel electrophoresis; Typing; Genetic variance; Nucleotide sequence; Monoclonal antibodies; Serological surveys ER - TY - JOUR T1 - Examination of the neighborhood activation theory in normal and hearing-impaired listeners. AN - 85357459; pmid-11271971 AB - Experiments were conducted to examine the effects of lexical information on word recognition among normal hearing listeners and individuals with sensorineural hearing loss. The lexical factors of interest were incorporated in the Neighborhood Activation Model (NAM). Central to this model is the concept that words are recognized relationally in the context of other phonemically similar words. NAM suggests that words in the mental lexicon are organized into similarity neighborhoods and the listener is required to select the target word from competing lexical items. Two structural characteristics of similarity neighborhoods that influence word recognition have been identified; "neighborhood density" or the number of phonemically similar words (neighbors) for a particular target item and "neighborhood frequency" or the average frequency of occurrence of all the items within a neighborhood. A third lexical factor, "word frequency" or the frequency of occurrence of a target word in the language, is assumed to optimize the word recognition process by biasing the system toward choosing a high frequency over a low frequency word.Three experiments were performed. In the initial experiments, word recognition for consonant-vowel-consonant (CVC) monosyllables was assessed in young normal hearing listeners by systematically partitioning the items into the eight possible lexical conditions that could be created by two levels of the three lexical factors, word frequency (high and low), neighborhood density (high and low), and average neighborhood frequency (high and low). Neighborhood structure and word frequency were estimated computationally using a large, on-line lexicon-based Webster's Pocket Dictionary. From this program 400 highly familiar, monosyllables were selected and partitioned into eight orthogonal lexical groups (50 words/group). The 400 words were presented randomly to normal hearing listeners in speech-shaped noise (Experiment 1) and "in quiet" (Experiment 2) as well as to an elderly group of listeners with sensorineural hearing loss in the speech-shaped noise (Experiment 3).The results of three experiments verified predictions of NAM in both normal hearing and hearing-impaired listeners. In each experiment, words from low density neighborhoods were recognized more accurately than those from high density neighborhoods. The presence of high frequency neighbors (average neighborhood frequency) produced poorer recognition performance than comparable conditions with low frequency neighbors. Word frequency was found to have a highly significant effect on word recognition. Lexical conditions with high word frequencies produced higher performance scores than conditions with low frequency words.The results supported the basic tenets of NAM theory and identified both neighborhood structural properties and word frequency as significant lexical factors affecting word recognition when listening in noise and "in quiet." The results of the third experiment permit extension of NAM theory to individuals with sensorineural hearing loss. Future development of speech recognition tests should allow for the effects of higher level cognitive (lexical) factors on lower level phonemic processing. JF - Ear and hearing AU - Dirks, D D AU - Takayanagi, S AU - Moshfegh, A AU - Noffsinger, P D AU - Fausti, S A AD - National Center for Rehabilitative Auditory Research, Veterans Administration Medical Center, Portland, Oregon, USA. Y1 - 2001/02// PY - 2001 DA - Feb 2001 SP - 1 EP - 13 VL - 22 IS - 1 SN - 0196-0202, 0196-0202 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Aged, 80 and over KW - Female KW - *Hearing Loss, Sensorineural: diagnosis KW - Humans KW - Male KW - Middle Aged KW - Phonetics KW - Severity of Illness Index KW - *Speech Perception: physiology KW - Vocabulary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85357459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear+and+hearing&rft.atitle=Examination+of+the+neighborhood+activation+theory+in+normal+and+hearing-impaired+listeners.&rft.au=Dirks%2C+D+D%3BTakayanagi%2C+S%3BMoshfegh%2C+A%3BNoffsinger%2C+P+D%3BFausti%2C+S+A&rft.aulast=Dirks&rft.aufirst=D&rft.date=2001-02-01&rft.volume=22&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Ear+and+hearing&rft.issn=01960202&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Interpretation of Fables and Proverbs by African Americans With and Without Aphasia AN - 85301931; cs-286963 AB - There is a paucity of performance information for African American adults with aphasia on appraisal tasks, especially in comparison with performance by neurologically normal African American adults. We administered language impairment, functional communication, and discourse measures to neurologically normal African American adults and African American adults with aphasia. The neurologically normal group performed significantly better on the language impairment measure (Western Aphasia Battery), the functional communication measure (ASHA Functional Assessment of Communication Skills for Adults), providing the lesson in a fable discourse task, and spontaneous interpretation of proverbs. No significant differences between groups were observed on a picture description fable task or in performance on a multiple-choice proverb task. Few significant relationships were observed among measures in the neurologically normal group; however, the group with aphasia displayed a variety of significant relationships in their performance on the language impairment, functional communication, fable lesson, and interpretation of proverbs tasks. The results imply that fable and proverb discourse tasks may be valuable supplemental measures for characterizing communicative competence in African American adults who have aphasia. JF - American Journal of Speech-Language Pathology AU - Ulatowska, Hanna K AU - Wertz, Robert Terrence AU - Chapman, Sandra Bond AU - Hill, CaSaundra L AU - Thompson, Jennifer L AU - Keebler, Molly W AU - Olness, Gloria Streit AU - Parsons, Sharon D AU - Miller, Teya AU - Auther, Linda L AD - Program in Communication Disorders, School of Behavioral and Brain Sciences, University of Texas at Dallas; Department of Hearing and Speech Sciences, Bill Wilkerson Center for Otolaryngology and Communication Sciences, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Vanderbilt University; Psychology, School of Behavioral and Brain Sciences, University of Texas at Dallas; Callier Center for Communication Disorders, University of Texas at Dallas; Baylor University Medical Center, Dallas, TX; Parkland Health and Hospital System, Dallas, TX; Evanston NW Healthcare, Chicago, IL; Veterans Administration Medical Center, Nashville, TN PY - 2001 SP - 40 EP - 50 VL - 10 IS - 1 SN - 1058-0360, 1058-0360 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85301931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Speech-Language+Pathology&rft.atitle=Interpretation+of+Fables+and+Proverbs+by+African+Americans+With+and+Without+Aphasia&rft.au=Ulatowska%2C+Hanna+K%3BWertz%2C+Robert+Terrence%3BChapman%2C+Sandra+Bond%3BHill%2C+CaSaundra+L%3BThompson%2C+Jennifer+L%3BKeebler%2C+Molly+W%3BOlness%2C+Gloria+Streit%3BParsons%2C+Sharon+D%3BMiller%2C+Teya%3BAuther%2C+Linda+L&rft.aulast=Ulatowska&rft.aufirst=Hanna&rft.date=2001-02-01&rft.volume=10&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Speech-Language+Pathology&rft.issn=10580360&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The functional anatomy of gaze-evoked tinnitus and sustained lateral gaze. AN - 85169278; pmid-11222790 AB - OBJECTIVE: To identify neural sites associated with gaze-evoked tinnitus (GET), an unusual condition that may follow cerebellar-pontine angle surgery. METHODS: The authors examined eight patients with GET and used PET to map the neural sites activated by lateral gaze in them and seven age- and sex-matched control subjects. RESULTS: In patients with GET, tinnitus loudness and pitch increased with lateral gaze and, to a lesser extent, up and down gaze. Evidence for neural activity related to GET was seen in the auditory lateral pontine tegmentum or auditory cortex. GET-associated nystagmus appears to activate the cuneus and cerebellar vermis. These sites were found in addition to an extensive network that included frontal eye fields and other sites in frontal, parietal, and temporal cortex that were activated by lateral gaze in seven control subjects and the patients. The unilateral deafness in patients with GET was associated with expansion of auditory cortical areas responsive to tones delivered to the good ear. In addition to GET, unilateral deafness, end-gaze nystagmus, and facial nerve dysfunction were common. CONCLUSIONS: Patients with GET have plastic changes in multiple neural systems that allow neural activity associated with eye movement, including those associated with the neural integrator, to stimulate the auditory system. Anomalous auditory activation is enhanced by the failure of cross-modal inhibition to suppress auditory cortical activity. The time course for the development of GET suggests that it may be due to multiple mechanisms. JF - Neurology AU - Lockwood, A H AU - Wack, D S AU - Burkard, R F AU - Coad, M L AU - Reyes, S A AU - Arnold, S A AU - Salvi, Richard J AD - Centers for Positron Emission Tomography, Veterans Administration Western New York Health Care System, Buffalo 14215, USA.; Department of Communicative Disorders and Sciences, College of Arts and Sciences, State University of New York at Buffalo PY - 2001 SP - 472 EP - 480 VL - 56 IS - 4 SN - 0028-3878, 0028-3878 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85169278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=The+functional+anatomy+of+gaze-evoked+tinnitus+and+sustained+lateral+gaze.&rft.au=Lockwood%2C+A+H%3BWack%2C+D+S%3BBurkard%2C+R+F%3BCoad%2C+M+L%3BReyes%2C+S+A%3BArnold%2C+S+A%3BSalvi%2C+Richard+J&rft.aulast=Lockwood&rft.aufirst=A&rft.date=2001-02-01&rft.volume=56&rft.issue=4&rft.spage=472&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Structure-activity relationships for the hypertensinogenic activity of ouabain: role of the sugar and lactone ring. AN - 76979857; 11230321 AB - Elevated levels of an endogenous ouabain circulate in many patients with essential hypertension. However, in contrast to ouabain, digoxin does not induce hypertension. This study investigated the hypothesis that within a single cardiac glycoside, the structural elements that induce hypertension differ from those responsible for high potency as a sodium pump inhibitor. Normal male Sprague-Dawley rats received infusions of vehicle (VEH), rhamnose (RHA), ouabain (OUA), ouabagenin (OGN), dihydro-ouabain (DHO), iso-ouabain (ISO), and a lactone ring opened analog (ORO) at 30 microgram. kg(-1). 24 h(-1) for 5 weeks via subcutaneous osmotic pumps. Cuff pressures were taken weekly. At the end of the study, trunk blood was harvested, extracted by C18 column, and subjected to high-performance liquid chromatography. Fractions were analyzed for OUA, OGN, and DHO by immunoassay. In OUA-, OGN-, and DHO-infused rats, 1 main peak of immunoreactivity corresponding to the infused agent was found. No evidence of in vivo conversion to OUA or DHO was found for any analog except ORO. At 5 weeks, systolic blood pressures in VEH, RHA, OUA, OGN, DHO, ISO, and ORO were 132+/-2.5, 133+/-1.5, 159+/-2.6,* 154+/-4,* 167+/-4,* 171+/-2.2,* and 169+/-2.4* mm Hg, respectively (*P<0.01 versus VEH and RHA, P<0.05 versus OUA). The hypertensinogenic activity was greater than OUA in 3 analogs (DHO, ISO, and ORO) in which the lactone was saturated, conformationally restrained by linkage with the oxygen at C14, or opened, respectively. These compounds were weak inhibitors of dog kidney Na,K-ATPase. Thus, RHA and the unsaturated lactone ring are crucial to the high potency of OUA as an inhibitor of the sodium pump but appear to be unrelated to its ability to induce hypertension. The conclusion that this form of hypertension is mediated primarily by the steroid nucleus suggests also that OUA may have a mechanism of action independent of the sodium pump. JF - Hypertension (Dallas, Tex. : 1979) AU - Manunta, P AU - Hamilton, B P AU - Hamlyn, J M AD - Departments of Physiology and Medicine, School of Medicine, University of Maryland, and the Veterans Administration Medical Center, Baltimore, Md, USA. Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 472 EP - 477 VL - 37 IS - 2 Pt 2 KW - Cardiac Glycosides KW - 0 KW - Enzyme Inhibitors KW - Lactones KW - Steroids KW - Ouabain KW - 5ACL011P69 KW - Sodium-Potassium-Exchanging ATPase KW - EC 3.6.3.9 KW - Rhamnose KW - QN34XC755A KW - Index Medicus KW - Animals KW - Infusions, Intravenous KW - Spectrophotometry, Ultraviolet KW - Rhamnose -- chemistry KW - Chromatography, High Pressure Liquid KW - Structure-Activity Relationship KW - Magnetic Resonance Spectroscopy KW - Rats KW - Rats, Sprague-Dawley KW - Steroids -- blood KW - Lactones -- chemistry KW - Enzyme Inhibitors -- pharmacology KW - Steroids -- chemistry KW - Blood Pressure -- drug effects KW - Male KW - Sodium-Potassium-Exchanging ATPase -- antagonists & inhibitors KW - Hypertension -- chemically induced KW - Hypertension -- blood KW - Ouabain -- chemistry KW - Cardiac Glycosides -- toxicity KW - Cardiac Glycosides -- pharmacology KW - Ouabain -- toxicity KW - Cardiac Glycosides -- chemistry KW - Ouabain -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76979857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Structure-activity+relationships+for+the+hypertensinogenic+activity+of+ouabain%3A+role+of+the+sugar+and+lactone+ring.&rft.au=Manunta%2C+P%3BHamilton%2C+B+P%3BHamlyn%2C+J+M&rft.aulast=Manunta&rft.aufirst=P&rft.date=2001-02-01&rft.volume=37&rft.issue=2+Pt+2&rft.spage=472&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=1524-4563&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-26 N1 - Date created - 2001-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Military and civilian penetrating eye trauma: anesthetic implications. AN - 72337184; 11759136 AB - In 20th century warfare, wounds from fragmentation weapons have become the number 1 cause of military hospital admissions during combat. Specifically, grenades, landmines, mortars, and artillery weapons have replaced guns and bullets. Consequently, penetrating eye injuries and maxillofacial injuries in the military have escalated dramatically. In the civilian sector, pipe bombs, explosive bottles used in gang warfare, and terrorist bombs, which are all fragmentation weapons, have generated new studies in the care of patients with penetrating eye injury. This change in the wounding pattern is, documented internationally in military-medical literature and in civilian-medical literature of relief agencies such as the International Committee of the Red Cross and the Red Crescent. The anesthetic management of open eye injuries has been a running controversy for 40 years in terms of the use of muscle relaxants. Nondepolarizing agents carry the risk of aspiration and increased intraocular pressure when trauma patients are intubated prematurely during rapid-sequence induction for "full stomachs." Succinylcholine would be the logical relaxant of choice for a rapid-sequence induction, but succinylcholine raises intraocular pressure. In many cases, the literature specifically contraindicates succinylcholine in the open eye injury for fear of extruding the content of the eye. A review of the vital assessment for the patient with a penetrating eye injury, as well as a comparative analysis of the literature, is presented. The conclusion favors pretreatment with a nondepolarizing agent and the use of succinylcholine during rapid-sequence induction. The eye injury itself is not the primary concern of this article. The primary concern is that open eye injuries serve as hallmarks for for more dangerous injuries. Penetrating open eye injuries merit extensive clinical assessment that can be life saving. JF - AANA journal AU - Biehl, J W AD - Veterans Administration Medical Center, Baltimore, Md., USA. Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 31 EP - 37 VL - 69 IS - 1 SN - 0094-6354, 0094-6354 KW - Neuromuscular Depolarizing Agents KW - 0 KW - Succinylcholine KW - J2R869A8YF KW - Nursing KW - Neuromuscular Depolarizing Agents -- therapeutic use KW - Neuromuscular Depolarizing Agents -- adverse effects KW - Humans KW - Succinylcholine -- therapeutic use KW - Decision Making KW - Succinylcholine -- adverse effects KW - Blast Injuries -- surgery KW - Anesthesia -- methods KW - Wounds, Penetrating -- surgery KW - Eye Injuries -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72337184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AANA+journal&rft.atitle=Military+and+civilian+penetrating+eye+trauma%3A+anesthetic+implications.&rft.au=Biehl%2C+J+W&rft.aulast=Biehl&rft.aufirst=J&rft.date=2001-02-01&rft.volume=69&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=AANA+journal&rft.issn=00946354&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-08 N1 - Date created - 2001-12-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of atorvastatin 15 mg/week on serum lipids in patients with hypercholesterolemia. AN - 70594588; 11165974 AB - Atorvastatin 15 mg/week was administered to 21 patients with hypercholesterolemia for 2 months. The mean low-density lipoprotein concentration decreased by 20% after treatment. JF - The American journal of cardiology AU - Rindone, J P AU - Dzurick, J AU - Hiller, D AU - Peralta, B AD - Veterans Affairs Medical Center, Prescott, Arizona 86313, USA. joseph.rindone@med.va.gov Y1 - 2001/02/01/ PY - 2001 DA - 2001 Feb 01 SP - 341 EP - 2, A9 VL - 87 IS - 3 SN - 0002-9149, 0002-9149 KW - Heptanoic Acids KW - 0 KW - Lipids KW - Pyrroles KW - Atorvastatin Calcium KW - 48A5M73Z4Q KW - Cholesterol KW - 97C5T2UQ7J KW - Abridged Index Medicus KW - Index Medicus KW - Coronary Disease -- drug therapy KW - Cholesterol -- blood KW - Drug Administration Schedule KW - Coronary Disease -- blood KW - Dose-Response Relationship, Drug KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Female KW - Pyrroles -- adverse effects KW - Lipids -- blood KW - Pyrroles -- administration & dosage KW - Hypercholesterolemia -- blood KW - Heptanoic Acids -- administration & dosage KW - Hypercholesterolemia -- drug therapy KW - Heptanoic Acids -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70594588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Effect+of+atorvastatin+15+mg%2Fweek+on+serum+lipids+in+patients+with+hypercholesterolemia.&rft.au=Rindone%2C+J+P%3BDzurick%2C+J%3BHiller%2C+D%3BPeralta%2C+B&rft.aulast=Rindone&rft.aufirst=J&rft.date=2001-02-01&rft.volume=87&rft.issue=3&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-22 N1 - Date created - 2001-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of tuberculosis (TB) on HIV-1 activity in dually infected patients AN - 18248969; 5306930 AB - Active TB in HIV-1-infected subjects is associated with increased HIV-1-related immunodeficiency and mortality. We assessed plasma viral load in HIV-1-infected patients with pulmonary TB (HIV/TB) and non-TB symptomatic HIV-1-infected patients (HIV). HIV-1 load was higher in HIV/TB compared with HIV at higher CD4 counts (> 500 / mu l) (P 900 / mu l to < 200/ mu l). HIV-1 RNA in serum and PBMC correlated to one another, and both were markedly higher in HIV/TB compared with HIV/C with higher CD4 counts. Also, during a longitudinal study of anti-tuberculous chemoprophylaxis in HIV-1-infected patients, 10 subjects who developed TB had serologies before, at the time, and after the diagnosis of TB. These HIV/TB patients had an increase in viral load (average 2.5-fold) at the time of diagnosis of TB (P < 0.05). Overall, these data indicate that the transcriptional activity of HIV-1 is enhanced in HIV-1-infected patients with active TB, especially during early HIV-1 disease. As TB often is an early HIV-1 opportunistic infection, it may particularly favour early viral replication and dissemination, and therefore contribute to progression of HIV-1 disease. JF - Clinical and Experimental Immunology AU - Toossi, Z AU - Mayanja-Kizza, H AU - Hirsch, C S AU - Edmonds, K L AU - Spahlinger, T AU - Hom, D L AU - Aung, H AU - Mugyenyi, P AU - Ellner, J J AU - Whalen, C W AD - Department of Medicine, Case Western Reserve University and Veterans Administration Medical Center, Cleveland, OH, USA, zxt2@po.cwru.edu Y1 - 2001/02// PY - 2001 DA - Feb 2001 SP - 233 EP - 238 PB - Blackwell Science Ltd VL - 123 IS - 2 SN - 0009-9104, 0009-9104 KW - man KW - HIV-1 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Acquired immune deficiency syndrome KW - Opportunist infection KW - RNA KW - Human immunodeficiency virus 1 KW - Polymerase chain reaction KW - Tuberculosis KW - Mixed infection KW - Mycobacterium tuberculosis KW - F 06801:Bacteria KW - J 02845:Ear, nose and respiratory tract KW - F 06860:CMI KW - F 06800:Viruses KW - V 22004:AIDS: Clinical aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18248969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Experimental+Immunology&rft.atitle=Impact+of+tuberculosis+%28TB%29+on+HIV-1+activity+in+dually+infected+patients&rft.au=Toossi%2C+Z%3BMayanja-Kizza%2C+H%3BHirsch%2C+C+S%3BEdmonds%2C+K+L%3BSpahlinger%2C+T%3BHom%2C+D+L%3BAung%2C+H%3BMugyenyi%2C+P%3BEllner%2C+J+J%3BWhalen%2C+C+W&rft.aulast=Toossi&rft.aufirst=Z&rft.date=2001-02-01&rft.volume=123&rft.issue=2&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Experimental+Immunology&rft.issn=00099104&rft_id=info:doi/10.1046%2Fj.1365-2249.2001.01401.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Human immunodeficiency virus 1; Acquired immune deficiency syndrome; Tuberculosis; Mixed infection; Polymerase chain reaction; RNA; Opportunist infection DO - http://dx.doi.org/10.1046/j.1365-2249.2001.01401.x ER - TY - JOUR T1 - Development of an exercise expert system for older adults AN - 18143020; 5125917 AB - The purpose of this study was to develop a computerized exercise expert system (CEES) that creates tailored exercise plans for older adults. A panel of experts was selected in the areas of medicine, exercise physiology, health promotion, exercise psychology, and gerontology. The experts communicated with the principal investigator and the project members by mail, email, telephone, and expert meetings. A two-day workshop was held during the second year for the project members as well as local and national experts to review the CEES. The CEES demonstrated adequate inter-rater reliability (0.80) and criterion validity (0.70). Content validity was achieved by literature review and expert opinion. The CEES gathers information on the elder's health status, clinical factors, and exercise determinants that characterize specific barriers or incentives to exercise. The software program then develops individualized exercise prescriptions that are customized to older adults. JF - Journal of Rehabilitation Research and Development AU - Boyette, L W AU - Lloyd, A AU - Manuel, S AU - Boyette, JE AU - Echt, K V AD - Atlanta Veterans Affairs Medical Center, Rehabilitation Research and Development Center (151R), 1670 Clairmont Road, Decatur, GA 30033, USA, boyette.lisa_@atlanta.va.gov Y1 - 2001/02// PY - 2001 DA - Feb 2001 SP - 79 EP - 91 VL - 38 IS - 1 SN - 0007-506X, 0007-506X KW - Physical Education Index KW - Development KW - Adults KW - Exercise KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18143020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Development+of+an+exercise+expert+system+for+older+adults&rft.au=Boyette%2C+L+W%3BLloyd%2C+A%3BManuel%2C+S%3BBoyette%2C+JE%3BEcht%2C+K+V&rft.aulast=Boyette&rft.aufirst=L&rft.date=2001-02-01&rft.volume=38&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=0007506X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Exercise; Adults; Development ER - TY - JOUR T1 - An increase in expression of a Mycobacterium tuberculosis mycolyl transferase gene (fbpB) occurs early after infection of human monocytes AN - 17883680; 5122101 AB - Changes in the mRNA levels of two Mycobacterium tuberculosis genes (fbpB known as antigen 85B, and hspX known as Acr) were studied in infected human monocytes. Antigen 85B is an enzyme involved in cell wall biosynthesis and is also a major target of the immune response. Acr is a stress protein believed to be involved in the bacillary response to adverse conditions and in non-replicating persistence. During the first 24 h of intracellular infection, the intramonocyte 85B mRNA level increased 54-fold (P = 0.00001) and 14.6 times in comparison with the 16S ribosomal rRNA. In contrast, the Acr mRNA fell 14.3 times. Although monocyte cytokine production was very variable, the 24 h secretion of tumour necrosis factor (TNF)- alpha correlated with the 85B-16S RNA ratio at 24 h (r = 0.77, P < 0.01). Furthermore, the addition of exogenous TNF- alpha to cultures was associated with a twofold increase in the 85B-16S ratio and, conversely, neutralization of endogenous TNF- alpha reduced the ratio. As antigen 85B also induces TNF- alpha , the positive feedback implied by our findings suggests a previously unsuspected role for this protein in the immunopathogenesis of tuberculosis. JF - Molecular Microbiology AU - Wilkinson, R J AU - Desjardin, LE AU - Islam, N AU - Gibson, B M AU - Kanost, R A AU - Wilkinson, KA AU - Poelman, D AU - Eisenach, K D AU - Toossi, Z AD - Division of Infectious Diseases, Case Western Reserve University, Biomedical Research Building, 10900 Euclid Avenue, Cleveland, OH 44106-4984, USA.~ Medical Research Service, J. L. McClellan Memorial Veterans' Administration Hospital, 4300 West 7th St., Little Rock, AR 72205, USA.~ Wellcome Centre for Clinical Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow HA1 3UJ, UK. Y1 - 2001/02// PY - 2001 DA - Feb 2001 SP - 813 EP - 821 PB - Blackwell Science Ltd VL - 39 IS - 3 SN - 0950-382X, 0950-382X KW - Acr gene KW - antigen 85B KW - mycolyl transferase KW - Microbiology Abstracts B: Bacteriology KW - Tumor necrosis factor-^a KW - Tuberculosis KW - Monocytes KW - rRNA 16S KW - Mycobacterium tuberculosis KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17883680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=An+increase+in+expression+of+a+Mycobacterium+tuberculosis+mycolyl+transferase+gene+%28fbpB%29+occurs+early+after+infection+of+human+monocytes&rft.au=Wilkinson%2C+R+J%3BDesjardin%2C+LE%3BIslam%2C+N%3BGibson%2C+B+M%3BKanost%2C+R+A%3BWilkinson%2C+KA%3BPoelman%2C+D%3BEisenach%2C+K+D%3BToossi%2C+Z&rft.aulast=Wilkinson&rft.aufirst=R&rft.date=2001-02-01&rft.volume=39&rft.issue=3&rft.spage=813&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; rRNA 16S; Tuberculosis; Tumor necrosis factor-^a; Monocytes ER - TY - JOUR T1 - Toleration of high doses of angiotensin-converting enzyme inhibitors in patients with chronic heart failure: results from the ATLAS trial. The Assessment of Treatment with Lisinopril and Survival. AN - 70592910; 11176729 AB - Treatment with angiotensin-converting enzyme (ACE) inhibitors reduces mortality and morbidity in patients with chronic heart failure (CHF), but most affected patients are not receiving these agents or are being treated with doses lower than those found to be efficacious in trials, primarily because of concerns about the safety and tolerability of these agents, especially at the recommended doses. The present study examines the safety and tolerability of high- compared with low-dose lisinopril in CHF. The Assessment of Lisinopril and Survival study was a multicenter, randomized, double-blind trial in which patients with or without previous ACE inhibitor treatment were stabilized receiving medium-dose lisinopril (12.5 or 15.0 mg once daily [OD]) for 2 to 4 weeks and then randomized to high- (35.0 or 32.5 mg OD) or low-dose (5.0 or 2.5 mg OD) groups. Patients with New York Heart Association classes II to IV CHF and left ventricular ejection fractions of no greater than 0.30 (n = 3164) were randomized and followed up for a median of 46 months. We examined the occurrence of adverse events and the need for discontinuation and dose reduction during treatment, with a focus on hypotension and renal dysfunction. Of 405 patients not previously receiving an ACE inhibitor, doses in only 4.2% could not be titrated to the medium doses required for randomization because of symptoms possibly related to hypotension (2.0%) or because of renal dysfunction or hyperkalemia (2.3%). Doses in more than 90% of randomized patients in the high- and low-dose groups were titrated to their assigned target, and the mean doses of blinded medication in both groups remained similar throughout the study. Withdrawals occurred in 27.1% of the high- and 30.7% of the low-dose groups. Subgroups presumed to be at higher risk for ACE inhibitor intolerance (blood pressure, or =132.6 micromol/L [> or =1.5 mg/dL]; age, > or =70 years; and patients with diabetes) generally tolerated the high-dose strategy. These findings demonstrate that ACE inhibitor therapy in most patients with CHF can be successfully titrated to and maintained at high doses, and that more aggressive use of these agents is warranted. JF - Archives of internal medicine AU - Massie, B M AU - Armstrong, P W AU - Cleland, J G AU - Horowitz, J D AU - Packer, M AU - Poole-Wilson, P A AU - Rydén, L AD - Department of Medicine, University of California-San Francisco and the Department of Veterans Affairs Medical Center, USA. Barry.Massie@med.va.gov Y1 - 2001/01/22/ PY - 2001 DA - 2001 Jan 22 SP - 165 EP - 171 VL - 161 IS - 2 SN - 0003-9926, 0003-9926 KW - Angiotensin-Converting Enzyme Inhibitors KW - 0 KW - Lisinopril KW - E7199S1YWR KW - Abridged Index Medicus KW - Index Medicus KW - Hypotension -- chemically induced KW - Drug Administration Schedule KW - Double-Blind Method KW - Humans KW - Aged KW - Hyperkalemia -- chemically induced KW - Male KW - Female KW - Kidney Diseases -- chemically induced KW - Lisinopril -- adverse effects KW - Heart Failure -- drug therapy KW - Angiotensin-Converting Enzyme Inhibitors -- adverse effects KW - Lisinopril -- administration & dosage KW - Angiotensin-Converting Enzyme Inhibitors -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70592910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Toleration+of+high+doses+of+angiotensin-converting+enzyme+inhibitors+in+patients+with+chronic+heart+failure%3A+results+from+the+ATLAS+trial.+The+Assessment+of+Treatment+with+Lisinopril+and+Survival.&rft.au=Massie%2C+B+M%3BArmstrong%2C+P+W%3BCleland%2C+J+G%3BHorowitz%2C+J+D%3BPacker%2C+M%3BPoole-Wilson%2C+P+A%3BRyd%C3%A9n%2C+L&rft.aulast=Massie&rft.aufirst=B&rft.date=2001-01-22&rft.volume=161&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-29 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preliminary Analyses of Hebrew Verbal Fluency Measures AN - 85551858; 200209893 AB - Hebrew language versions of phonemic & semantic fluency were administered to samples of normal control participants & individuals who had been hospitalized for 24 hours following a head injury. For the control sample, verbal fluency tasks were normally distributed & significantly correlated with education. The head injury sample's word generation was significantly lesser than that of the control's & not at all related to educational attainment. The findings provide evidence for the use of Hebrew fluency measures for clinical assessment & the need for collecting normative data across education levels. 1 Table, 9 References. Adapted from the source document JF - Applied Neuropsychology AU - Axelrod, Bradley N AU - Tomer, Rachel AU - Fisher, Tali AU - Aharon-Peretz, Judith AD - John D. Dingell Dept Veterans Affairs Medical Center, Detroit, MI bradley.axelrod@med.va.gov Y1 - 2001///0, PY - 2001 DA - 0, 2001 SP - 248 EP - 250 VL - 8 IS - 4 SN - 0908-4282, 0908-4282 KW - Memory (52750) KW - Brain Damage (09400) KW - Verbal Tasks (93800) KW - Lexical Access (46630) KW - Hebrew (31650) KW - Fluency (24910) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85551858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Neuropsychology&rft.atitle=Preliminary+Analyses+of+Hebrew+Verbal+Fluency+Measures&rft.au=Axelrod%2C+Bradley+N%3BTomer%2C+Rachel%3BFisher%2C+Tali%3BAharon-Peretz%2C+Judith&rft.aulast=Axelrod&rft.aufirst=Bradley&rft.date=2001-01-01&rft.volume=8&rft.issue=4&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Applied+Neuropsychology&rft.issn=09084282&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Brain Damage (09400); Verbal Tasks (93800); Fluency (24910); Lexical Access (46630); Memory (52750); Hebrew (31650) ER - TY - JOUR T1 - Possible Demographic Influences on Differentiating Normal from Aphasic Performance AN - 85539115; 200107371 AB - To determine the psychometric validity of current language impairment, communication activity limitation, & quality of life measures for differentiating normal from chronically aphasic adults, we examined possible threats to test accuracy by the demographic variables age, educational level, & gender. A total of 18 chronically aphasic & 18 nonaphasic adults were evaluated with six measures. The results of correlational analyses indicated that, within the normal adult & aphasic adult groups, there exist significant relationships between some, but not all, demographic variables & performance on language impairment, communication activity limitation, & quality of life measures. Moreover, for certain variables, the strengths of these relationships differ significantly between normal & aphasic groups. Thus, adjustments in test scores or norms may be necessary to diagnose the presence or absence of aphasia. Otherwise, the tests' ability to differentiate between normal & aphasic adults may be compromised. 4 Tables, 1 Appendix, 25 References. Adapted from the source document JF - Journal of Communication Disorders AU - Ross, Katherine B AU - Wertz, Robert T AD - Audiology & Speech Pathology Dept, Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ katherine.ross3@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 115 EP - 130 VL - 34 IS - 1-2 SN - 0021-9924, 0021-9924 KW - Education (20900) KW - Psychometric Analysis (69210) KW - Aphasia (03400) KW - Age Differences (01150) KW - Sex Differences (77850) KW - Test Validity and Reliability (88800) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85539115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Communication+Disorders&rft.atitle=Possible+Demographic+Influences+on+Differentiating+Normal+from+Aphasic+Performance&rft.au=Ross%2C+Katherine+B%3BWertz%2C+Robert+T&rft.aulast=Ross&rft.aufirst=Katherine&rft.date=2001-01-01&rft.volume=34&rft.issue=1-2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Journal+of+Communication+Disorders&rft.issn=00219924&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCDIAI N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Test Validity and Reliability (88800); Age Differences (01150); Education (20900); Sex Differences (77850); Psychometric Analysis (69210) ER - TY - JOUR T1 - Swallowing physiology of sequential straw drinking. AN - 85364599; pmid-11453563 AB - The goal of this study was to examine deglutitive physiology during sequential straw drinking in healthy young adults (n = 15) to learn how sequential swallowing differs from single swallows. The physiology of single swallows has been studied extensively in healthy adults and in adults with a variety of debilitating conditions, but the physiology of sequential swallows has not been studied adequately. Videofluoroscopic analysis revealed three distinct patterns of hyolaryngeal complex (HLC) movement during sequential straw swallows: opening of the laryngeal vestibule after each swallow (Type I, 53%), continued vestibule closure after each swallow (Type II, 27%), and interchangeable vestibule opening and closing during the swallow sequence (Mixed, 20%). Unlike discrete swallowing, the onset of the pharyngeal swallow occurred when the bolus was inferior to the valleculae in the majority of subjects and was significantly associated with HLC movement pattern. The leading bolus edge was inferior to the valleculae at swallow onset for Type II movement patterns. For Type I movement patterns, bolus position at swallow onset was randomly distributed between three anatomical positions: superior to the valleculae, at the level of the valleculae, and inferior to the valleculae. Preswallow pharyngeal bolus accumulation, which is common during mastication, was evident and significantly associated with the HLC pattern of opened laryngeal vestibule after each swallow. These data suggest that in healthy young adults, sequential swallows differ physiologically from discrete swallows and indicate substantial variability in deglutitive biomechanics. JF - Dysphagia AU - Daniels, S K AU - Foundas, A L AD - Speech Pathology Section, Veterans Affairs Medical Center, New Orleans, Louisiana 70112-1262, USA. stephanie.daniels@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 176 EP - 182 VL - 16 IS - 3 SN - 0179-051X, 0179-051X KW - National Library of Medicine KW - Adult KW - Biomechanics KW - *Deglutition: physiology KW - *Drinking: physiology KW - Humans KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85364599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dysphagia&rft.atitle=Swallowing+physiology+of+sequential+straw+drinking.&rft.au=Daniels%2C+S+K%3BFoundas%2C+A+L&rft.aulast=Daniels&rft.aufirst=S&rft.date=2001-01-01&rft.volume=16&rft.issue=3&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Dysphagia&rft.issn=0179051X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Scabies associated with radiation therapy for cutaneous T-cell lymphoma. AN - 77066189; 11314859 AB - Scabies, infection with Sarcoptes scabiei, is known to be predisposed to by poor body hygiene, environmental exposure, and systemic immunodeficiency. We report the case of an 83-year-old man with Sezary's syndrome who developed scabies limited to the skin of the upper chest, the same location where he had previously received electron beam radiation treatments for cutaneous T-cell lymphoma. Histologic and immunohistochemical studies demonstrated that sections of the previously irradiated right and left chest skin, compared to non-irradiated chest, abdominal, and leg skin, had infestation by scabies, diminished involvement by T-cell lymphoma, and notably reduced numbers of Langerhans cells. These findings suggest that the development of scabies may be predisposed to by local cutaneous radiation therapy, and that it may be mediated by local cutaneous immunodeficiency secondary to reduced numbers of Langerhans cells. JF - Annals of clinical and laboratory science AU - McGregor, D H AU - Yang, Q AU - Fan, F AU - Talley, R L AU - Topalovski, M AD - Department of Pathology and Laboratory Medicine, Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA. mcgregor.d.@kansas-city.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 103 EP - 107 VL - 31 IS - 1 SN - 0091-7370, 0091-7370 KW - Index Medicus KW - Skin -- parasitology KW - Aged, 80 and over KW - Langerhans Cells -- pathology KW - Humans KW - Skin -- pathology KW - Gene Rearrangement KW - Aged KW - Sezary Syndrome -- complications KW - Male KW - Skin Neoplasms -- genetics KW - Lymphoma, T-Cell, Cutaneous -- complications KW - Lymphoma, T-Cell, Cutaneous -- genetics KW - Lymphoma, T-Cell, Cutaneous -- radiotherapy KW - Skin Neoplasms -- radiotherapy KW - Skin Neoplasms -- pathology KW - Skin Neoplasms -- complications KW - Lymphoma, T-Cell, Cutaneous -- pathology KW - Scabies -- etiology KW - Radiotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77066189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+clinical+and+laboratory+science&rft.atitle=Scabies+associated+with+radiation+therapy+for+cutaneous+T-cell+lymphoma.&rft.au=McGregor%2C+D+H%3BYang%2C+Q%3BFan%2C+F%3BTalley%2C+R+L%3BTopalovski%2C+M&rft.aulast=McGregor&rft.aufirst=D&rft.date=2001-01-01&rft.volume=31&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Annals+of+clinical+and+laboratory+science&rft.issn=00917370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-17 N1 - Date created - 2001-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Barriers to progress--the impact of tolerability problems. AN - 76970958; 11252523 AB - Side-effects of antipsychotic treatment are important factors in patients' compliance with treatment regimens. Of particular relevance to compliance are extrapyramidal symptoms (EPS), sedation, weight gain and sexual dysfunction. The new, atypical antipsychotics offer several tolerability benefits over conventional neuroleptics, particularly with respect to EPS. However, differences in their receptor binding characteristics result in different side-effect profiles. All novel antipsychotics have a high 5-HT2 to D2 receptor binding ratio, which is postulated to be important for a low liability for EPS. Ziprasidone, a new antipsychotic in the late stages of clinical development, has a low affinity for some receptor types, activation of which has been linked with adverse events such as sedation, postural hypotension, weight gain and cognitive impairment; for example, ziprasidone has minimal activity at muscarinic (M1), histaminergic (H1) and alpha1-adrenergic receptors. In short- and long-term clinical trials, ziprasidone had a low liability for side-effects typically associated with poor compliance, such as EPS, weight gain and sexual dysfunction. The tolerability profiles of the new antipsychotics represent a major improvement over the older neuroleptics. The more favourable the benefit/risk ratios of these new drugs throughout all phases of treatment, the greater the likelihood that patients will have better outcomes. JF - International clinical psychopharmacology AU - Casey, D E AD - Psychiatric Research and Psychopharmacology, Mental Health Division, Veterans Affairs Medical Center, Portland, Oregon, USA. daniel.casey@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - S15 EP - S19 VL - 16 Suppl 1 SN - 0268-1315, 0268-1315 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Hypotension, Orthostatic KW - Humans KW - Sexual Dysfunction, Physiological -- chemically induced KW - Cognition Disorders -- chemically induced KW - Weight Gain KW - Basal Ganglia Diseases -- chemically induced KW - Patient Compliance KW - Antipsychotic Agents -- therapeutic use KW - Antipsychotic Agents -- adverse effects KW - Psychotic Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76970958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+clinical+psychopharmacology&rft.atitle=Barriers+to+progress--the+impact+of+tolerability+problems.&rft.au=Casey%2C+D+E&rft.aulast=Casey&rft.aufirst=D&rft.date=2001-01-01&rft.volume=16+Suppl+1&rft.issue=&rft.spage=S15&rft.isbn=&rft.btitle=&rft.title=International+clinical+psychopharmacology&rft.issn=02681315&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-07 N1 - Date created - 2001-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stress-induced enhancement of auditory startle: an animal model of posttraumatic stress disorder. AN - 72420910; 11822211 AB - An innovative animal model of posttraumatic stress disorder (PTSD) is proposed in which nonhabituation of the acoustic startle response is developed in rats subsequent to tailshock exposure. Subjects (n = 31) received 30 minutes of intermittent tail shock on 2 days followed by exposure to the tailshock apparatus on the third day. Compared to baseline startle reactions, 9 of 31 tailshock-exposed rats developed nonhabituation of startle response reactions during the subsequent 3 weeks of testing. No control rats developed nonhabituation of startle reactions over a similar time period. These data suggest that this system models useful aspects of clinical PTSD emphasizing nonhabituation of startle reactions as a dependent variable. The method consistently identifies a subgroup of rats that develop persistent nonhabituation of startle in response to a tailshock-stress paradigm. JF - Psychiatry AU - Garrick, T AU - Morrow, N AU - Shalev, A Y AU - Eth, S AD - West Los Angeles VA Medical Center, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA. Thomas.Garrick@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 346 EP - 354 VL - 64 IS - 4 SN - 0033-2747, 0033-2747 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Disease Models, Animal KW - Behavior, Animal -- physiology KW - Habituation, Psychophysiologic KW - Male KW - Stress Disorders, Post-Traumatic -- psychology KW - Reinforcement (Psychology) KW - Reflex, Startle -- physiology KW - Noise -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72420910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry&rft.atitle=Stress-induced+enhancement+of+auditory+startle%3A+an+animal+model+of+posttraumatic+stress+disorder.&rft.au=Garrick%2C+T%3BMorrow%2C+N%3BShalev%2C+A+Y%3BEth%2C+S&rft.aulast=Garrick&rft.aufirst=T&rft.date=2001-01-01&rft.volume=64&rft.issue=4&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=Psychiatry&rft.issn=00332747&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-16 N1 - Date created - 2002-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of atypical antipsychotics on weight and serum lipid levels. AN - 72410205; 11806486 AB - Psychiatrists have become particularly concerned about health issues in patients with schizophrenia because of emerging data that link some of the newer atypical antipsychotics with both significant weight gain and increases in serum triglyceride levels. Excessive weight gain during antipsychotic therapy has an adverse effect on health and medication compliance, while hyperlipidemia presents an additional cardiovascular risk factor in patients with schizophrenia who typically smoke, are inactive, and possess poor dietary habits. An understanding of appropriate monitoring for metabolic adverse effects is important for those who prescribe atypical antipsychotics, as is a working knowledge of behavioral and pharmacologic treatments for weight gain and hyperlipidemia. JF - The Journal of clinical psychiatry AU - Meyer, J M AD - San Diego Veterans Affairs Medical Center and the Department of Psychiatry, University of California, 92161, USA. jonathan.meyer@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 27 EP - 34; discussion 40-1 VL - 62 Suppl 27 SN - 0160-6689, 0160-6689 KW - Antipsychotic Agents KW - 0 KW - Lipids KW - Index Medicus KW - Risk Factors KW - Hypertriglyceridemia -- chemically induced KW - Humans KW - Drug Monitoring KW - Hypertriglyceridemia -- blood KW - Obesity -- chemically induced KW - Lipids -- blood KW - Schizophrenia -- blood KW - Antipsychotic Agents -- therapeutic use KW - Body Weight -- drug effects KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72410205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Effects+of+atypical+antipsychotics+on+weight+and+serum+lipid+levels.&rft.au=Meyer%2C+J+M&rft.aulast=Meyer&rft.aufirst=J&rft.date=2001-01-01&rft.volume=62+Suppl+27&rft.issue=&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-07 N1 - Date created - 2002-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A definitive study of snakebite. 1968. AN - 72372242; 11769926 JF - Wilderness & environmental medicine AU - Snyder, C C AU - Pickins, J E AU - Knowles, R P AU - Emerson, J L AU - Hines, W A AD - Department of Surgery, University of Utah College of Medicine and Veterans Administration Hospital, Salt Lake City, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 276 EP - 279 VL - 12 IS - 4 SN - 1080-6032, 1080-6032 KW - Antivenins KW - 0 KW - Snake Venoms KW - Index Medicus KW - Emerson KW - Knowles KW - Snyder KW - Hines KW - Pickins KW - Animals KW - History, 20th Century KW - Viperidae KW - Humans KW - Antivenins -- history KW - Antivenins -- therapeutic use KW - Emergency Treatment -- history KW - Snake Venoms -- history KW - Snake Bites -- therapy KW - Snake Bites -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72372242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wilderness+%26+environmental+medicine&rft.atitle=A+definitive+study+of+snakebite.+1968.&rft.au=Snyder%2C+C+C%3BPickins%2C+J+E%3BKnowles%2C+R+P%3BEmerson%2C+J+L%3BHines%2C+W+A&rft.aulast=Snyder&rft.aufirst=C&rft.date=2001-01-01&rft.volume=12&rft.issue=4&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Wilderness+%26+environmental+medicine&rft.issn=10806032&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-11 N1 - Date created - 2001-12-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Wilderness Environ Med. 2001 Winter;12(4):273-5 [11769925] N1 - People - Snyder; Pickins; Knowles; Emerson; Hines N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Snyder; Pickins; Knowles; Emerson; Hines ER - TY - JOUR T1 - Helicobacter pylori and NSAIDs--what interaction. AN - 72297531; 11718528 AB - Much controversy surrounds the interaction of Helicobacter pylori infection and the use of Aspirin (ASA) or non-aspirin nonsteroidal anti-inflammatory drugs (NANSAIDs). The issue is comprised of many components, best dealt with singly. In summary, the severity of drug-associated gastritis, but not its incidence or prevalence, is influenced by infection prior to ASA or NANSAID therapy. Furthermore, the severity of dyspeptic symptoms appears worse in infected drug users. Both Chemical and Helicobacter gastritis, by increasing neutrophils in the tissue, lead to ulcers, although the induction of prostaglandin synthesis by inflammation in some circumstances may also be mildly protective. More ulcers are found in Hp+ve than Hp-ve users of NSAIDS, but ulcers in the stomach may heal more easily with acid suppressive therapy in infected patients. Eradication of infection is beneficial in aspirin users and in those beginning NANSAID therapy. Adaptation to aspirin is confined to Hp-ve cases. However, in long-term users of NANSAIDs, H. pylori eradication does not appear to speed ulcer healing, reduce recurrence, or prevent complications. These are best achieved by long-term maintenance therapy with a proton-pump inhibitor drug. JF - The European journal of surgery. Supplement. : = Acta chirurgica. Supplement AU - McCarthy, D M AD - Division of Gastroenterology & Hepatology, University of New Mexico HSC and Veterans Administration Medical Center, Albuquerque, USA. denis.mccarthy2@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 56 EP - 65 IS - 586 SN - 1102-416X, 1102-416X KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Index Medicus KW - Humans KW - Peptic Ulcer -- chemically induced KW - Helicobacter pylori KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Helicobacter Infections -- complications KW - Gastritis -- physiopathology KW - Gastritis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72297531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+journal+of+surgery.+Supplement.+%3A+%3D+Acta+chirurgica.+Supplement&rft.atitle=Helicobacter+pylori+and+NSAIDs--what+interaction.&rft.au=McCarthy%2C+D+M&rft.aulast=McCarthy&rft.aufirst=D&rft.date=2001-01-01&rft.volume=&rft.issue=586&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=The+European+journal+of+surgery.+Supplement.+%3A+%3D+Acta+chirurgica.+Supplement&rft.issn=1102416X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-28 N1 - Date created - 2001-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lack of effect of moderate Purkinje cell loss on working memory. AN - 72292359; 11718998 AB - 192 immunoglobulin G-saporin (192-sap) is an immunotoxin which targets the cholinergic basal forebrain after injection into either the ventricular system or the parenchyma of the rat brain. When injected by the i.c.v. route, 192-sap kills some cerebellar Purkinje cells in addition to its more extensive killing of the cholinergic basal forebrain. Behaviorally, i.c.v. injections of 192-sap result in impaired performance in a variety of experimental paradigms of learning and memory including a working memory task in the radial maze. The current study examined the contribution, if any, of immunotoxin-induced Purkinje cell loss to impaired performance in the radial maze. To meet this aim, we used i.c.v. injection of another immunotoxin, OX7-saporin (OX7-sap), at a dose that produced Purkinje cell loss of similar extent to that produced by i.c.v. 192-sap. We then compared these OX7-sap-injected rats with 192-sap-injected rats in a radial maze working memory task. We found a working memory impairment only in the 192-sap-injected rats. These data show that moderate Purkinje cell loss alone is insufficient to impair working memory. Furthermore, the data are consistent with the idea that the working memory deficit observed in 192-sap-injected animals is likely due to lesioning of the cholinergic basal forebrain. JF - Neuroscience AU - Wrenn, C C AU - Wiley, R G AD - Laboratory of Experimental Neurology, Veterans Administration Medical Center, Nashville, TN 37212, USA. wrennc@intra.nimh.nih.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 433 EP - 445 VL - 107 IS - 3 SN - 0306-4522, 0306-4522 KW - Antibodies, Monoclonal KW - 0 KW - Immunoconjugates KW - Immunotoxins KW - OX7-saporin KW - Ribosome Inactivating Proteins, Type 1 KW - N-Glycosyl Hydrolases KW - EC 3.2.2.- KW - Index Medicus KW - Animals KW - Maze Learning -- physiology KW - Neurons -- drug effects KW - Cholinergic Fibers -- physiology KW - Rats, Inbred BN KW - Rats KW - Choice Behavior -- drug effects KW - Prosencephalon -- physiology KW - Immunotoxins -- pharmacology KW - Injections KW - Memory -- physiology KW - Purkinje Cells -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72292359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Lack+of+effect+of+moderate+Purkinje+cell+loss+on+working+memory.&rft.au=Wrenn%2C+C+C%3BWiley%2C+R+G&rft.aulast=Wrenn&rft.aufirst=C&rft.date=2001-01-01&rft.volume=107&rft.issue=3&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-15 N1 - Date created - 2001-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Experimental options in the treatment of heart failure: the role of cytokine antagonism. AN - 71374886; 12634895 AB - Recent studies have identified the importance of biologically active molecules, such as neurohormones, as mediators of disease progression in heart failure. More recently, it has become apparent that, in addition to neurohormones, another portfolio of biologically active molecules, termed cytokines, are also expressed in the setting of heart failure. This article will review recent clinical material that suggests that tumor necrosis factor, a pro-inflammatory cytokine, may contribute to disease progression in heart failure by virtue of the direct toxic effects that this molecule exerts on the heart and circulation. In addition, this article reviews the existing clinical literature, which suggests that cytokine antagonism is safe and potentially effective in patients with heart failure. JF - Heart failure monitor AU - Kalra, D AU - Bozkurt, B AU - Deswal, A AU - Torre-Amione, G AU - Mann, D L AD - Winters Center for Heart Failure Research, Veterans Administration Medical Center and Baylor College of Medicine, Houston, TX 77030, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 114 EP - 121 VL - 1 IS - 4 SN - 1470-8590, 1470-8590 KW - Adrenergic beta-Antagonists KW - 0 KW - Angiotensin-Converting Enzyme Inhibitors KW - Cytokines KW - Neurotransmitter Agents KW - Index Medicus KW - Coronary Circulation -- physiology KW - Animals KW - Neurotransmitter Agents -- physiology KW - Angiotensin-Converting Enzyme Inhibitors -- therapeutic use KW - Ventricular Remodeling -- drug effects KW - Humans KW - Cytokines -- physiology KW - Cytokines -- antagonists & inhibitors KW - Adrenergic beta-Antagonists -- therapeutic use KW - Coronary Circulation -- drug effects KW - Ventricular Remodeling -- physiology KW - Heart Failure -- drug therapy KW - Heart Failure -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71374886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Heart+failure+monitor&rft.atitle=Experimental+options+in+the+treatment+of+heart+failure%3A+the+role+of+cytokine+antagonism.&rft.au=Kalra%2C+D%3BBozkurt%2C+B%3BDeswal%2C+A%3BTorre-Amione%2C+G%3BMann%2C+D+L&rft.aulast=Kalra&rft.aufirst=D&rft.date=2001-01-01&rft.volume=1&rft.issue=4&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Heart+failure+monitor&rft.issn=14708590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-04 N1 - Date created - 2003-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Psychiatric care management for chronic addictive disorders: conceptual framework. AN - 71211733; 11579622 AB - Coexisting mental and addictive disorders are common, and service systems are not well configured to treat them. Psychiatrists frequently feel lacking in skills to address both the addictive disorder and the mental illness. Although programs for treating "dual disordered" patients have been under development, specialized programs are likely to provide treatment for only a minority of patients. Furthermore, many patients either do not respond to them or simply refuse to participate. This article describes care management, a clinical approach that can be applied to coexisting disorders by any practitioner. Care management complements rehabilitation treatment and completes the continuum of care. JF - The American journal on addictions AU - Willenbring, M L AD - Veterans Administration Medical Center and University of Minnesota, Minneapolis, Minn., USA. vhaminwillem@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 242 EP - 248 VL - 10 IS - 3 SN - 1055-0496, 1055-0496 KW - Index Medicus KW - Severity of Illness Index KW - Humans KW - Chronic Disease KW - Mental Disorders -- complications KW - Substance-Related Disorders -- complications KW - Mental Health Services -- standards KW - Substance-Related Disorders -- rehabilitation KW - Mental Health Services -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71211733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Psychiatric+care+management+for+chronic+addictive+disorders%3A+conceptual+framework.&rft.au=Willenbring%2C+M+L&rft.aulast=Willenbring&rft.aufirst=M&rft.date=2001-01-01&rft.volume=10&rft.issue=3&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-26 N1 - Date created - 2001-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Low-density lipoprotein induced actin cytoskeleton reorganization in endothelial cells: mechanisms of action. AN - 71202824; 11577705 AB - The inhibitory effects of the specific NADPH oxidase inhibitor, apocynin, and non-specific NADPH oxidase inhibitors, nordihydroguaiaretic acid (NDGA) and SKF525A, on the disruption of dense peripheral bands and formation of stress fibers in cultured human umbilical vein endothelial cells exposed to atherogenic low-density lipoprotein (LDL) levels has been investigated. Endothelial cells (EC) in vitro and in vivo exposed to high LDL-cholesterol levels have cytoskeletal remodeling with stress fiber formation and loss of dense peripheral bands. Cultured EC incubated with exogenously applied hydrogen peroxide (H2O2: 1 mM) have cytoskeletal structural changes much similar to those observed with high LDL exposure. Previous studies have 1) demonstrated that exposure to atherogenic LDL levels causes heightened EC H2O2 production, 2) identified the reactive oxygen species source, NADPH oxidase, in EC, and 3) shown that the specific NADPH oxidase inhibitor, apocynin, and non-specific NADPH oxidase inhibitors, NDGA and SKF525A, suppress H2O2 production increases in high LDL-perturbed EC. In the present study, the cytoskeletal structure of EC exposed to 330 mg/dl LDL-cholesterol, and incubated with or without apocynin, NDGA and SKF525A, was examined. Each of these compounds promoted the retention of dense peripheral bands and minimized stress fiber formation. These findings are consistent with NADPH oxidase and it's reactive oxygen species byproducts modulating the cytoskeleton reorganization observed in high LDL-induced EC perturbation. JF - Endothelium : journal of endothelial cell research AU - Holland, J A AU - Goss, R A AU - O'Donnell, R W AU - Chang, M M AU - Johnson, D K AU - Ziegler, L M AD - Department of Medicine, State University of New York Health Science Center Syracuse, 13210, USA. james.holland3@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 117 EP - 135 VL - 8 IS - 2 SN - 1062-3329, 1062-3329 KW - Acetophenones KW - 0 KW - Actins KW - Enzyme Inhibitors KW - Lipoproteins, LDL KW - Masoprocol KW - 7BO8G1BYQU KW - Proadifen KW - A510CA4CBT KW - acetovanillone KW - B6J7B9UDTR KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Index Medicus KW - Animals KW - Perfusion KW - Acetophenones -- pharmacology KW - Aorta, Abdominal -- ultrastructure KW - NADPH Oxidase -- antagonists & inhibitors KW - Humans KW - Umbilical Veins -- cytology KW - Rabbits KW - Arteriosclerosis -- chemically induced KW - Arteriosclerosis -- pathology KW - Microscopy, Fluorescence KW - Proadifen -- pharmacology KW - Cells, Cultured KW - Aorta, Thoracic -- ultrastructure KW - Enzyme Inhibitors -- pharmacology KW - Male KW - Masoprocol -- pharmacology KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Endothelium, Vascular -- cytology KW - Actin Cytoskeleton -- ultrastructure KW - Actins -- ultrastructure KW - Endothelium, Vascular -- ultrastructure KW - Actin Cytoskeleton -- drug effects KW - Lipoproteins, LDL -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71202824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endothelium+%3A+journal+of+endothelial+cell+research&rft.atitle=Low-density+lipoprotein+induced+actin+cytoskeleton+reorganization+in+endothelial+cells%3A+mechanisms+of+action.&rft.au=Holland%2C+J+A%3BGoss%2C+R+A%3BO%27Donnell%2C+R+W%3BChang%2C+M+M%3BJohnson%2C+D+K%3BZiegler%2C+L+M&rft.aulast=Holland&rft.aufirst=J&rft.date=2001-01-01&rft.volume=8&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Endothelium+%3A+journal+of+endothelial+cell+research&rft.issn=10623329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-21 N1 - Date created - 2001-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - From ETOH to FAB: the medicalization of therapy for pit viper envenomation. AN - 70940627; 11413771 JF - Transactions of the American Clinical and Climatological Association AU - Kitchens, C S AD - University of Florida, College of Medicine, Gainesville, FL 32610-0277, USA. craig.kitchens@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 117 EP - 135 VL - 112 SN - 0065-7778, 0065-7778 KW - Antivenins KW - 0 KW - Crotalid Venoms KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - History, 21st Century KW - History, 20th Century KW - Humans KW - History, 18th Century KW - History, Ancient KW - History, 19th Century KW - Antivenins -- history KW - Ethanol -- history KW - Antivenins -- therapeutic use KW - Ethanol -- therapeutic use KW - Crotalid Venoms -- toxicity KW - Snake Bites -- therapy KW - Crotalid Venoms -- history KW - Snake Bites -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70940627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+of+the+American+Clinical+and+Climatological+Association&rft.atitle=From+ETOH+to+FAB%3A+the+medicalization+of+therapy+for+pit+viper+envenomation.&rft.au=Kitchens%2C+C+S&rft.aulast=Kitchens&rft.aufirst=C&rft.date=2001-01-01&rft.volume=112&rft.issue=&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Transactions+of+the+American+Clinical+and+Climatological+Association&rft.issn=00657778&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-07 N1 - Date created - 2001-06-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Emerg Med. 2001 Feb;37(2):181-8 [11174237] Postgrad Med. 1966 Mar;39(3):265-9 [5911001] J Fla Med Assoc. 1968 Apr;55(4):330-7 [5646641] Toxicon. 1973 Oct;11(6):461-4 [4762264] JAMA. 1975 Jul 28;233(4):341-4 [1173647] J Fla Med Assoc. 1976 Mar;63(3):201-10 [175130] Thromb Res. 1977 Mar;10(3):487-94 [854881] JAMA. 1978 Aug 18;240(7):654-6 [671686] J Fla Med Assoc. 1980 Jan;67(1):21-7 [7351526] JAMA. 1982 Jan 22-29;247(4):461 [7054542] Am J Hematol. 1983 Jun;14(4):345-53 [6859033] Toxicon. 1984;22(2):177-82 [6729838] Lancet. 1986 Jul 26;2(8500):229 [2873481] Toxicon. 1987;25(4):455-8 [3617084] JAMA. 1987 Sep 25;258(12):1615-8 [3625968] Toxicon. 1987;25(12):1347-9 [3438923] Ann Emerg Med. 1988 Mar;17(3):254-6 [3257850] Am J Surg. 1989 Dec;158(6):543-7 [2589586] Ann Emerg Med. 1991 Jun;20(6):659-61 [2039106] Ann Emerg Med. 1992 Sep;21(9):1086-93 [1514719] Toxicon. 1992 May-Jun;30(5-6):573-9 [1519249] Hematol Oncol Clin North Am. 1992 Oct;6(5):1189-95 [1400081] Ann Emerg Med. 1997 Jul;30(1):33-9 [9209222] Ann Emerg Med. 1997 Jul;30(1):45-8 [9209224] Curr Opin Hematol. 1995 Sep;2(5):402-6 [9372026] Toxicon. 1999 Sep;37(9):1241-58 [10400286] Pediatrics. 1965 Aug;36:251-6 [14320035] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence of heart disease in asymptomatic chronic cocaine users. AN - 70897297; 11385188 AB - To determine the prevalence of heart disease in outpatient young asymptomatic chronic cocaine users, 35 cocaine users and 32 age-matched controls underwent resting and exercise electrocardiography (ECG) and Doppler echocardiography. Findings consistent with coronary artery disease were detected in 12 (34%) patients and 3 (9%) controls (p = 0.01). Decreased left ventricular systolic function was demonstrated in 5 (14%) patients, but in none of the controls (p = 0.055). Finally, resting and peak exercise abnormal left ventricular filling was detected in 38 and 35% of patients as compared to 19 and 9% of controls, respectively (p = 0.11 and 0.02, respectively). We conclude that coronary artery or myocardial disease is common (38%) in young asymptomatic chronic cocaine users. Therefore, screening ECG and echocardiography may be warranted in these patients. Copyright 2001 S. Karger AG, Basel. JF - Cardiology AU - Roldan, C A AU - Aliabadi, D AU - Crawford, M H AD - Cardiology, Veterans Affairs Medical Center and University of New Mexico Health Sciences Center, Albuquerque, NM, USA. Carlos.Roldan@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 25 EP - 30 VL - 95 IS - 1 SN - 0008-6312, 0008-6312 KW - Index Medicus KW - Cardiomyopathies -- etiology KW - Humans KW - Echocardiography KW - Ventricular Dysfunction, Left -- chemically induced KW - Heart Function Tests KW - Logistic Models KW - Electrocardiography KW - Adult KW - Coronary Disease -- chemically induced KW - Case-Control Studies KW - Cardiomyopathies -- chemically induced KW - Female KW - Male KW - Heart Diseases -- chemically induced KW - Cocaine-Related Disorders -- physiopathology KW - Heart Diseases -- physiopathology KW - Cocaine-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70897297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cardiology&rft.atitle=Prevalence+of+heart+disease+in+asymptomatic+chronic+cocaine+users.&rft.au=Roldan%2C+C+A%3BAliabadi%2C+D%3BCrawford%2C+M+H&rft.aulast=Roldan&rft.aufirst=C&rft.date=2001-01-01&rft.volume=95&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Cardiology&rft.issn=00086312&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-09-13 N1 - Date created - 2001-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Biphasic effects of selegiline on striatal dopamine: lack of effect on methamphetamine-induced dopamine depletion. AN - 70837170; 11358284 AB - We tested the hypothesis that selegiline can attenuate dopamine depletion if administered following high doses of methamphetamine that cause neurotoxicity in the striatum. Methamphetamine produced decreases of 50% or greater in both striatal concentrations of dopamine and combined concentrations of homovanillic acid and DOPAC in mice. For animals not exposed to methamphetamine, chronic treatment with selegiline over 18 days caused biphasic effects on striatal dopamine content, with decreases, no effect, or increases observed for mice receiving treatment with 0.02, 0.2, and 2.0 mg/kg, respectively. Selegiline failed to modify methamphetamine-induced reductions in striatal dopamine content or combined concentrations of homovanillic acid and DOPAC. Significant increases in mortality following the onset of selegiline treatment (24 hours after the initial dose of methamphetamine) occurred in methamphetamine-treated mice that received saline or 2.0 mg/kg of selegiline, but not for mice treated with 0.02 or 0.2 mg/kg of selegiline. These results indicate that selegiline fails to attenuate dopamine depletion when administered chronically following exposure to methamphetamine, but may attenuate methamphetamine-induced mortality. In control animals that did not receive methamphetamine, low doses of selegiline produced decreases the concentration of striatal dopamine, while high dose treatment caused increases in striatal dopamine content. JF - Neurochemical research AU - Grasing, K AU - Azevedo, R AU - Karuppan, S AU - Ghosh, S AD - Veterans Administration Medical Center, Kansas City, Missouri 64128, USA. kenneth.grasing@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 65 EP - 74 VL - 26 IS - 1 SN - 0364-3190, 0364-3190 KW - Dopamine Uptake Inhibitors KW - 0 KW - Monoamine Oxidase Inhibitors KW - Neurotoxins KW - Selegiline KW - 2K1V7GP655 KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Neurotoxins -- pharmacology KW - Mice KW - Male KW - Selegiline -- pharmacology KW - Corpus Striatum -- metabolism KW - Methamphetamine -- pharmacology KW - Dopamine -- metabolism KW - Corpus Striatum -- drug effects KW - Monoamine Oxidase Inhibitors -- pharmacology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70837170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+research&rft.atitle=Biphasic+effects+of+selegiline+on+striatal+dopamine%3A+lack+of+effect+on+methamphetamine-induced+dopamine+depletion.&rft.au=Grasing%2C+K%3BAzevedo%2C+R%3BKaruppan%2C+S%3BGhosh%2C+S&rft.aulast=Grasing&rft.aufirst=K&rft.date=2001-01-01&rft.volume=26&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Neurochemical+research&rft.issn=03643190&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-11 N1 - Date created - 2001-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic alterations in head and neck cancer: interactions among environmental carcinogens, cell cycle control, and host DNA repair. AN - 70590642; 11123872 AB - Head and neck squamous cell carcinomas (HNSCC) arise as a consequence of cumulative genetic changes brought about by continued exposure to carcinogens associated with tobacco and alcohol use, influenced by viral agents such as human papillomaviruses, in a background of acquired or heritable genetic susceptibility. The presence of widespread genomic instability in HNSCC, such as cytogenetic aberrations, allelic imbalance/loss of heterozygosity, and microsatellite instability, suggests that there is an imperfection in the host DNA repair machinery. Genomic instability with progressive accumulation of detrimental genetic alterations appears to be dependent upon a circuitous interaction between the environmental genotoxic insults and the host DNA repair machinery, the functional integrity of which is governed by the proper cell cycle control and host DNA repair capacity. Thus, it can be hypothesized that continued exposure to environmental carcinogens (ie, longstanding history of smoking and drinking), loss of proper cell cycle control (eg, inactivation of p53 or p16 tumor suppressor genes or amplification of the proto-oncongene cyclin D1), and impaired DNA repair capacity (both inherited and acquired) are prerequisites in head and neck carcinogenesis. JF - Current oncology reports AU - Fan, C Y AD - Department of Pathology and Otolaryngology, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA. chun.fan@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 66 EP - 71 VL - 3 IS - 1 SN - 1523-3790, 1523-3790 KW - Carcinogens KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Neoplasm Staging KW - DNA Damage KW - Cell Cycle -- physiology KW - Humans KW - Alcohol Drinking -- adverse effects KW - Disease Progression KW - Prognosis KW - Smoking -- adverse effects KW - Carcinogens -- metabolism KW - Risk Factors KW - Female KW - Male KW - Survival Analysis KW - Carcinogens -- adverse effects KW - DNA Repair -- genetics KW - Head and Neck Neoplasms -- metabolism KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- mortality KW - Carcinoma, Squamous Cell -- genetics KW - Head and Neck Neoplasms -- pathology KW - Head and Neck Neoplasms -- mortality KW - Carcinoma, Squamous Cell -- metabolism KW - Head and Neck Neoplasms -- genetics KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70590642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+oncology+reports&rft.atitle=Genetic+alterations+in+head+and+neck+cancer%3A+interactions+among+environmental+carcinogens%2C+cell+cycle+control%2C+and+host+DNA+repair.&rft.au=Fan%2C+C+Y&rft.aulast=Fan&rft.aufirst=C&rft.date=2001-01-01&rft.volume=3&rft.issue=1&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Current+oncology+reports&rft.issn=15233790&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-18 N1 - Date created - 2001-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rhabdomyolysis secondary to a drug interaction between simvastatin and clarithromycin. AN - 70590407; 11197581 AB - To report a case of rhabdomyolysis resulting from concomitant use of clarithromycin and simvastatin. A 64-year-old African-American man was admitted to the hospital for worsening renal failure, elevated creatine phosphokinase, diffuse muscle pain, and severe muscle weakness. About three weeks prior to admission, the patient was started on clarithromycin for sinusitis. The patient had been receiving simvastatin for approximately six months. He was treated aggressively with intravenous hydration, sodium bicarbonate, and hemodialysis. A muscle biopsy revealed necrotizing myopathy secondary to a toxin. The patient continued to receive intermittent hemodialysis until his death from infectious complications that occurred three months after admission. There were several factors that could have increased his risk for developing rhabdomyolysis, including chronic renal failure. Clarithromycin is a potent inhibitor of CYP3A4, the major enzyme responsible for simvastatin metabolism. The concomitant administration of macrolide antibiotics and other hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors have resulted in previous reports of rhabdomyolysis. Other factors may increase the risk of this drug interaction, including the administration of other medications that are associated with myopathy, underlying renal insufficiency, and administration of high doses of HMG-CoA reductase inhibitors. Macrolide antibiotics inhibit the metabolism of HMG-CoA reductase inhibitors that are metabolized by CYP3A4 (i.e., atorvastatin, cerivastatin, lovastatin, simvastatin). This interaction may result in myopathy and rhabdomyolysis, particularly in patients with renal insufficiency or those who are concurrently taking medications associated with myopathy. JF - The Annals of pharmacotherapy AU - Lee, A J AU - Maddix, D S AD - University of the Pacific, Stockton, CA, USA. lee.audrey_J@sanfrancisco.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 26 EP - 31 VL - 35 IS - 1 SN - 1060-0280, 1060-0280 KW - Anti-Bacterial Agents KW - 0 KW - Hypolipidemic Agents KW - Simvastatin KW - AGG2FN16EV KW - Clarithromycin KW - H1250JIK0A KW - Index Medicus KW - Drug Interactions KW - Humans KW - Hyperlipidemias -- drug therapy KW - Sinusitis -- drug therapy KW - Middle Aged KW - Male KW - Simvastatin -- therapeutic use KW - Simvastatin -- adverse effects KW - Anti-Bacterial Agents -- therapeutic use KW - Hypolipidemic Agents -- therapeutic use KW - Rhabdomyolysis -- chemically induced KW - Anti-Bacterial Agents -- adverse effects KW - Rhabdomyolysis -- pathology KW - Hypolipidemic Agents -- adverse effects KW - Clarithromycin -- therapeutic use KW - Clarithromycin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70590407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Rhabdomyolysis+secondary+to+a+drug+interaction+between+simvastatin+and+clarithromycin.&rft.au=Lee%2C+A+J%3BMaddix%2C+D+S&rft.aulast=Lee&rft.aufirst=A&rft.date=2001-01-01&rft.volume=35&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-08 N1 - Date created - 2001-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cyclooxygenase 2 and the kidney. AN - 70579313; 11195058 AB - Cyclooxygenase metabolizes arachidonic acid to a family of bioactive fatty acids designated prostaglandins. Two isoforms of cyclooxygenase exist, designated COX1 and COX2. These isoforms are expressed in distinct but important areas of the kidney. COX1 predominates in vascular smooth muscle and collecting ducts, whereas COX2 predominates in the macula densa and nearby cells in the cortical thick ascending limb. COX2 is also highly expressed in medullary interstitial cells. Whereas COX1 expression does not exhibit dynamic regulation, COX2 expression is subject to regulation by several environmental conditions, including salt intake, water intake, medullary tonicity, growth factors, cytokines, and adrenal steroids. Recently, COX2-selective non-steroidal anti-inflammatory drugs have become widely available. Many of the renal effects of non-selective non-steroidal anti-inflammatory drugs (including sodium retention, decreased glomerular filtration rate, and effects on renin-angiotensin levels) appear to be mediated by the inhibition of COX2 rather than COX1. Therefore, in contrast to the gastrointestinal-sparing effects of COX2-selective non-steroidal anti-inflammatory drugs, when considering the kidney, the same caution must be applied when using COX2-selective inhibitors as has been used with traditional non-selective non-steroidal anti-inflammatory drugs. JF - Current opinion in nephrology and hypertension AU - Breyer, M D AU - Harris, R C AD - Department of Medicine, Veterans Administration Medical Center and Vanderbilt University, Nashville, Tennessee, USA. matthew.breyer@mcmail.vanderbilt.edu Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 89 EP - 98 VL - 10 IS - 1 SN - 1062-4821, 1062-4821 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Isoenzymes KW - Membrane Proteins KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Index Medicus KW - Kidney Diseases -- physiopathology KW - Animals KW - Anti-Inflammatory Agents, Non-Steroidal -- antagonists & inhibitors KW - Humans KW - Kidney Diseases -- chemically induced KW - Prostaglandin-Endoperoxide Synthases -- physiology KW - Isoenzymes -- physiology KW - Kidney -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70579313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+nephrology+and+hypertension&rft.atitle=Cyclooxygenase+2+and+the+kidney.&rft.au=Breyer%2C+M+D%3BHarris%2C+R+C&rft.aulast=Breyer&rft.aufirst=M&rft.date=2001-01-01&rft.volume=10&rft.issue=1&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+nephrology+and+hypertension&rft.issn=10624821&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-08 N1 - Date created - 2001-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of every-third-day versus daily low-dose aspirin therapy on serum thromboxane concentrations in healthy men and women. AN - 70577915; 11190906 AB - Aspirin's antithrombotic effect is mediated predominately by inhibition of platelet cyclooxygenase-1, leading to a decline in serum thromboxane A2 concentrations. We performed a placebo-controlled, randomized, double-blind trial to determine whether aspirin could be given at 3-day intervals and still achieve potent serum thromboxane inhibition. One hundred nine healthy men and women with no recent exposure to aspirin and no contraindications to its use participated. Subjects received 325 mg, 81 mg, or 40 mg of plain aspirin every third day, with placebo on other days; 81 mg of aspirin every day; or placebo every day. Serum concentrations of thromboxane B2 (the metabolite of thromboxane A2) were measured at 3-day intervals during a 31-day treatment period, as well as 4, 7, and 14 days after treatment ended. Serum thromboxane B2 concentrations were nearly identical during treatment with 325 mg of aspirin every third day or 81 mg of aspirin per day (86% inhibition [84%, 89%] and 85% inhibition [73%, 96%], respectively). An aspirin dose of 81 mg every third day was nearly as potent (74% inhibition [70%, 79%]), whereas 40 mg of aspirin every third day achieved only 50% inhibition (40%, 60%). Every-third-day low-dose aspirin regimens (325 and 81 mg) deserve comparison with daily low-dose aspirin regimens in controlled clinical trials because the former regimens could prove to have equal efficacy with reduced toxicity. JF - Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis AU - Feldman, M AU - Cryer, B AU - Rushin, K AU - Betancourt, J AD - Medical Service, Dallas Department of Veterans Affairs Medical Center and University of Texas Southwestern Medical School, 75216, USA. feldman.mark@dallas.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 53 EP - 57 VL - 7 IS - 1 SN - 1076-0296, 1076-0296 KW - Platelet Aggregation Inhibitors KW - 0 KW - Thromboxanes KW - Thromboxane B2 KW - 54397-85-2 KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Pilot Projects KW - Middle Aged KW - Adolescent KW - Time Factors KW - Male KW - Female KW - Thromboxane B2 -- blood KW - Platelet Aggregation Inhibitors -- administration & dosage KW - Thromboxanes -- blood KW - Aspirin -- adverse effects KW - Aspirin -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70577915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+applied+thrombosis%2Fhemostasis+%3A+official+journal+of+the+International+Academy+of+Clinical+and+Applied+Thrombosis%2FHemostasis&rft.atitle=A+comparison+of+every-third-day+versus+daily+low-dose+aspirin+therapy+on+serum+thromboxane+concentrations+in+healthy+men+and+women.&rft.au=Feldman%2C+M%3BCryer%2C+B%3BRushin%2C+K%3BBetancourt%2C+J&rft.aulast=Feldman&rft.aufirst=M&rft.date=2001-01-01&rft.volume=7&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Clinical+and+applied+thrombosis%2Fhemostasis+%3A+official+journal+of+the+International+Academy+of+Clinical+and+Applied+Thrombosis%2FHemostasis&rft.issn=10760296&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-03 N1 - Date created - 2001-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Predictors and outcomes of outpatient mental health care: a 4-year prospective study of elderly Medicare patients with substance use disorders. AN - 70575829; 11176542 AB - Many elderly inpatients have substance use disorders; recent treatment guidelines suggest that they should receive regular outpatient mental health care after discharge from hospital. The prevalence, predictors, and outcomes of outpatient mental health care obtained by elderly Medicare patients with substance use disorders were examined. A longitudinal prospective follow-up was performed. Data from Medicare Provider Analysis and Review Record and Part B Medicare Annual Data were used to identify elderly inpatients with substance use disorders (n = 4,961) and determine their outpatient mental health care 4 years following hospital discharge. Only 12% to 17% of surviving elderly substance abuse patients received outpatient mental health care in each of 4 years after discharge. Cumulatively over 4 years, approximately 18% of surviving patients obtained diagnostic/evaluative mental health services, 22% obtained psychotherapy, and 9% received medication management. Of patients who obtained outpatient mental health care, 57% made 10 or fewer outpatient mental health visits over the entire 4 years. Younger, non-black, and female patients were more likely to obtain mental health outpatient care, as were patients with prior substance-related hospitalizations, dual diagnoses, and fewer medical conditions. Prompt outpatient mental health care was predictively associated with higher likelihood of mental health readmissions and, among patients with drug disorders, lower mortality. Very few elderly Medicare substance abuse patients obtain outpatient mental health care, perhaps because of health or economic barriers. JF - Medical care AU - Brennan, P L AU - Kagay, C R AU - Geppert, J J AU - Moos, R H AD - Center for Health Care Evaluation, VA Palo Alto Health Care System and Stanford University Medical Center, California 94304, USA. penny.brennan@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 39 EP - 49 VL - 39 IS - 1 SN - 0025-7079, 0025-7079 KW - Index Medicus KW - Alcoholism -- rehabilitation KW - Analysis of Variance KW - Sex Factors KW - Humans KW - Medicare KW - Aged KW - Patient Readmission KW - Prospective Studies KW - Logistic Models KW - Risk Factors KW - Treatment Outcome KW - Follow-Up Studies KW - United States -- epidemiology KW - Female KW - Male KW - Mental Health Services -- utilization KW - Substance-Related Disorders -- mortality KW - Substance-Related Disorders -- rehabilitation KW - Aftercare -- utilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70575829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=Predictors+and+outcomes+of+outpatient+mental+health+care%3A+a+4-year+prospective+study+of+elderly+Medicare+patients+with+substance+use+disorders.&rft.au=Brennan%2C+P+L%3BKagay%2C+C+R%3BGeppert%2C+J+J%3BMoos%2C+R+H&rft.aulast=Brennan&rft.aufirst=P&rft.date=2001-01-01&rft.volume=39&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=00257079&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-01 N1 - Date created - 2001-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug resistance mechanisms in acute leukemia. AN - 70575547; 11148681 AB - Markers of anticancer drug resistance are predictive of treatment response and outcome in patients with acute myeloid leukemia. Immunologic detection of the drug efflux pumps, P-glycoprotein (Pgp) and multidrug resistance-associated protein 1 (MRP1), correlate with functional assays of drug resistance. These accumulation defects also appear operable in acute lymphoblastic leukemia. Many of the efflux pumps identified share significant structural homology with the large superfamily of ATP-binding cassette transporters. Other markers such as lung-resistance protein, bcl-2, and breast cancer-resistance protein, have been described in acute myeloid leukemia patients although their pathophysiology and clinical relevance are less clear and the methodology for their quantification are not well standardized. Preclinical studies have shown that small molecules capable of reversing efflux can restore drug sensitivity in resistant tumor models. Although initial clinical studies were limited by both potency and specificity of the reverser, later studies with more effective reversers have in many instances been limited by pharmacokinetic interactions exacerbating the clinical toxicities of chemotherapy. Although one large randomized study has demonstrated a proven survival advantage without increased toxicity using cyclosporine, the inconsistent results with other modulators raise doubt as to the utility and overall strategy of using drug efflux blockers in patients with established Pgp overexpression. Many of these patients have additional resistance mechanisms, and achieving meaningful clinical responses will likely require more complex clinical strategies. Preventing or delaying development of drug resistance in chemosensitive patients represents another therapeutic strategy to be tested. JF - Current opinion in oncology AU - Chauncey, T R AD - Marrow Transplant Unit, VA Puget Sound Health Care System, Seattle, Washington, USA. thomas.chauncey@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 21 EP - 26 VL - 13 IS - 1 SN - 1040-8746, 1040-8746 KW - Biomarkers, Tumor KW - 0 KW - Multidrug Resistance-Associated Proteins KW - P-Glycoprotein KW - Index Medicus KW - Phenotype KW - Gene Expression Regulation, Neoplastic KW - Randomized Controlled Trials as Topic KW - Drug Interactions KW - Humans KW - Prognosis KW - Survival Analysis KW - Leukemia -- drug therapy KW - P-Glycoprotein -- pharmacology KW - P-Glycoprotein -- genetics KW - ATP-Binding Cassette Transporters -- pharmacology KW - Biomarkers, Tumor -- analysis KW - Drug Resistance, Neoplasm KW - Leukemia -- physiopathology KW - Leukemia -- genetics KW - Drug Resistance, Multiple UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70575547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+oncology&rft.atitle=Drug+resistance+mechanisms+in+acute+leukemia.&rft.au=Chauncey%2C+T+R&rft.aulast=Chauncey&rft.aufirst=T&rft.date=2001-01-01&rft.volume=13&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+oncology&rft.issn=10408746&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-15 N1 - Date created - 2001-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Superoxide dismutase and pulmonary oxygen toxicity: lessons from transgenic and knockout mice (Review). AN - 70541017; 11115602 AB - Superoxide (O2-) has been implicated in the pathogenesis of pulmonary O2 toxicity. The studies using transgenic and knockout mice of each of the three isoforms of superoxide dismutase (SOD) e.g. , CuZnSOD, MnSOD and extracellular SOD (EC-SOD), have demonstrated that O2- produced in the mitochondria from its electron transport system and extracellular O2- generated by infiltrating neutrophils, and possibly its derivatives e.g., hydroxyl radical and peroxynitrite, are important mediators of hyperoxia-induced pulmonary injury, while cytoplasmic O2- plays a limited, if any, role in the pathogenesis of pulmonary O2 toxicity. Distal airway epithelial cells including type II alveolar and non-ciliated bronchiolar epithelial cells, are important targets for O2 radicals under the hyperoxic condition. The accessibility of these distal airway epithelial cells to in vivo gene transfer through the tracheal route of administration, suggests the potential for in vivo transfer of MnSOD and EC-SOD genes as a future approach in the prevention of pulmonary O2 toxicity. JF - International journal of molecular medicine AU - Tsan, M F AD - Research Service (151), Stratton VA Medical Center, Albany, NY 12208, USA. min-fu.tsan@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 13 EP - 19 VL - 7 IS - 1 SN - 1107-3756, 1107-3756 KW - Superoxides KW - 11062-77-4 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Animals KW - Superoxides -- metabolism KW - Mice KW - Mice, Transgenic KW - Mice, Knockout KW - Oxygen -- toxicity KW - Oxygen -- metabolism KW - Lung -- drug effects KW - Superoxide Dismutase -- metabolism KW - Superoxide Dismutase -- genetics KW - Lung -- pathology KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70541017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+molecular+medicine&rft.atitle=Superoxide+dismutase+and+pulmonary+oxygen+toxicity%3A+lessons+from+transgenic+and+knockout+mice+%28Review%29.&rft.au=Tsan%2C+M+F&rft.aulast=Tsan&rft.aufirst=M&rft.date=2001-01-01&rft.volume=7&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=International+journal+of+molecular+medicine&rft.issn=11073756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2000-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - An Assessment of Blind Rehabilitation Training and Technology Utilization of Visually Impaired Veterans T2 - Southern Sociological Society AN - 61736640; 2001S40261 AB - While considerable data has been developed on veterans attending VA blind rehabilitation programs, very little information is available on veterans who are unable or chose not to avail themselves of these services. This information is crucial in the design &/or optimization of the delivery of clinical services & assistive technology to this veteran population. Visually impaired veterans (N = 14,100) were surveyed in an effort to obtain basic demographic information, date & type of last blind rehabilitation service, receipt of prosthetic devices from the VA, living situation, visual status, current use of computer technology, as well as perceived specific rehabilitation needs. The typical demographic profile of survey respondents was that of a recreationally active, 71-80-year-old person living with a spouse, family member, or roommate. Findings from these data demonstrate that 43.2% of respondents had never received VA-sponsored blind rehabilitation training, & that younger veterans appear to receive VA blind rehabilitation services more often than do older veterans. These findings suggest a potential disparity in service delivery of VA-sponsored rehabilitation training programs for blind & visually impaired veterans. JF - Southern Sociological Society AU - Williams, Michael D Y1 - 2001///0, PY - 2001 DA - 0, 2001 KW - Veterans KW - Blind KW - Vocational Rehabilitation KW - Medical Technology KW - United States of America KW - Social Services Utilization KW - proceeding KW - 2148: social problems and social welfare; social work & welfare services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61736640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Southern+Sociological+Society&rft.atitle=An+Assessment+of+Blind+Rehabilitation+Training+and+Technology+Utilization+of+Visually+Impaired+Veterans&rft.au=Williams%2C+Michael+D&rft.aulast=Williams&rft.aufirst=Michael&rft.date=2001-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Southern+Sociological+Society&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2009-03-10 N1 - Publication note - 2001 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Gender Awareness among Veterans Administration Health-Care Workers: Existing Strengths and Areas for Improvement AN - 61509409; 200204656 AB - In response to the growing number of women within the Veterans Health Administration (VHA), along with the challenge of meeting their health care needs in a historically male-focused setting, VHA has supported a variety of research projects aimed at evaluating & improving the status of women's health & health care experiences. While these efforts have primarily focused on aspects of care such as the availability & accessibility of services & the provision of timely care, this study focused on the contribution of interpersonal aspects of care. Specifically, staff gender awareness, conceptualized as health care workers' gender role ideology or attitudes, gender sensitivity, & knowledge was examined. Findings revealed both strengths & weaknesses in domains of staff gender awareness components. 3 Tables, 39 References. Adapted from the source document. JF - Women and Health AU - Vogt, Dawne S AU - Stone, Erika R AU - Salgado, Dawn M AU - King, Lynda A AU - King, Daniel W AU - Savarese, Vincent W AD - National Center Post-traumatic Stress Disorder, Boston, MA vogt.dawne@boston.va.gov Y1 - 2001///0, PY - 2001 DA - 0, 2001 SP - 65 EP - 83 VL - 34 IS - 4 SN - 0363-0242, 0363-0242 KW - Veterans KW - Health Professions KW - Northern States KW - Womens Health Care KW - Sex Role Attitudes KW - Practitioner Patient Relationship KW - Knowledge KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61509409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women+and+Health&rft.atitle=Gender+Awareness+among+Veterans+Administration+Health-Care+Workers%3A+Existing+Strengths+and+Areas+for+Improvement&rft.au=Vogt%2C+Dawne+S%3BStone%2C+Erika+R%3BSalgado%2C+Dawn+M%3BKing%2C+Lynda+A%3BKing%2C+Daniel+W%3BSavarese%2C+Vincent+W&rft.aulast=Vogt&rft.aufirst=Dawne&rft.date=2001-01-01&rft.volume=34&rft.issue=4&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Women+and+Health&rft.issn=03630242&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - WOHEDI N1 - SubjectsTermNotLitGenreText - Womens Health Care; Health Professions; Sex Role Attitudes; Veterans; Knowledge; Practitioner Patient Relationship; Northern States ER - TY - JOUR T1 - Putting Theory into Practice: A Psychologist's Story AN - 61504371; 200103792 AB - A diagnosis of breast cancer is a frightening & life-changing experience. It affects not only the physical body, but also one's psychological well-being & basic assumptions about the world. Paradoxically, having breast cancer can provide an opportunity for personal growth & finding new meaning in life. While coping with cancer is basically an individual task, coping skills, social support, & an empathic therapist can help the breast cancer patient manage this stressful time. This article explores my own experience with breast cancer & the resources & coping strategies that were most helpful in getting through this frightening time. I will discuss how my experience forced me to face my own mortality & led me to an inner strength & courage that I had not used before. By joining the ranks of those who have faced intense anxiety & fear during a serious life crisis, I have greater empathy for & understanding of my own patients' struggles. 17 References. Adapted from the source document. JF - Women & Therapy AU - Fischer, Pamela C AD - Dept Veterans Affairs Medical Center, Oklahoma City Pamela.Fischer@med.va.gov Y1 - 2001///0, PY - 2001 DA - 0, 2001 SP - 101 EP - 109 VL - 23 IS - 1 SN - 0270-3149, 0270-3149 KW - breast cancer KW - Support Networks KW - Theory Practice Relationship KW - Womens Health Care KW - Narratives KW - Coping KW - Illness KW - Cancer KW - Empathy KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61504371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women+%26+Therapy&rft.atitle=Putting+Theory+into+Practice%3A+A+Psychologist%27s+Story&rft.au=Fischer%2C+Pamela+C&rft.aulast=Fischer&rft.aufirst=Pamela&rft.date=2001-01-01&rft.volume=23&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Women+%26+Therapy&rft.issn=02703149&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - WOTHDJ N1 - SubjectsTermNotLitGenreText - Womens Health Care; Cancer; Support Networks; Empathy; Theory Practice Relationship; Narratives; Illness; Coping ER - TY - JOUR T1 - Social Reinforcement of Substance Abuse Aftercare Group Therapy Attendance AN - 61492841; 200103929 AB - Although adherence to aftercare therapy in substance abuse treatment is associated with improved treatment outcome, relatively little research has explored methods of improving aftercare adherence. To improve on established methods of promoting aftercare adherence, 43 graduates of the 28-day intensive substance abuse treatment program at the Salem Veteran's Affairs Medical Center who received standard aftercare orientation are compared to 38 graduates who received the standard intervention plus social reinforcement of aftercare group therapy attendance. Clients who received social reinforcement attended more aftercare group sessions than did clients who received the standard treatment during the 8-week intervention (68.8% vs. 49.4% of sessions attended), & during the 4-week follow-up period (41.5% vs. 31.4% of sessions). These findings are noteworthy since the standard treatment had been shown to be effective in increasing aftercare adherence in prior studies (Lash, 1998; Lash & Blosser, 1999). Areas for future research are discussed. 1 Figure, 20 References. Adapted from the source document. JF - Journal of Substance Abuse Treatment AU - Lash, Steven J AU - Petersen, Gregory E AU - O'Connor, Edmund A, Jr AU - Lehmann, Lauren P AD - Substance Abuse Residential Rehabilitation Treatment Program, Veterans Affairs Medial Center, Salem, VA steven.lash@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 3 EP - 8 VL - 20 IS - 1 SN - 0740-5472, 0740-5472 KW - Veterans KW - Substance Abuse KW - Virginia KW - After Care KW - Treatment Programs KW - Treatment Compliance KW - Reinforcement KW - Treatment Methods KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61492841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Social+Reinforcement+of+Substance+Abuse+Aftercare+Group+Therapy+Attendance&rft.au=Lash%2C+Steven+J%3BPetersen%2C+Gregory+E%3BO%27Connor%2C+Edmund+A%2C+Jr%3BLehmann%2C+Lauren+P&rft.aulast=Lash&rft.aufirst=Steven&rft.date=2001-01-01&rft.volume=20&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Substance Abuse; Treatment Programs; After Care; Treatment Compliance; Reinforcement; Treatment Methods; Veterans; Virginia ER - TY - JOUR T1 - The effects of selection for larval behavior on adult life-history features in Drosophila melanogaster AN - 18284710; 5336280 AB - Selection for late-life fecundity and longevity in adult Drosophila melanogaster is well known to modify numerous characteristics of life history and physiology. We report experiments here in which selection applied to behavior affects features in an identical fashion. Selection for feeding rate of larval D. melanogaster modifies caloric intake, as measured by the uptake and incorporation of labeled glucose. Selection for slow larval feeding produced lines of D. melanogaster in which larvae synthesized significantly less lipid prior to pupation and eclosed to have low early-life fecundity and a long life as adults. They also had greater lifetime fecundity, but lower viability of egg to hatched adult. Alternatively, fast-feeding larvae incorporated more lipid before pupation and eclosed with high early-fecundity that declined rapidly throughout their short adult life. Slow-feeding populations also had a significantly enhanced expression of the stress-resistance genes CuZn-SOD, CATALASE, and HSP70. Selection on larval feeding behavior reproduced the antagonistic evolutionary trade-off found under selection for adult life span and mimicked the physiological response in life span as seen in many species when dietary restriction is imposed on adults. Thus, nutrient acquisition during development appears to share a common evolutionary and genetic basis with the allocation processes that determine adult life-history traits and the related phenotypic dietary restriction phenomena. JF - Evolution AU - Foley, P A AU - Luckinbill, L S AD - Department of Surgery, Veterans Administration Medical Center, Route 11S, Detroit, MI 48201, USA Y1 - 2001 PY - 2001 DA - 2001 SP - 2493 EP - 2502 VL - 55 IS - 12 SN - 0014-3820, 0014-3820 KW - Diptera KW - covariance KW - Animal Behavior Abstracts; Ecology Abstracts; Entomology Abstracts KW - Survival KW - Feeding behavior KW - Lipid metabolism KW - Fecundity KW - Life history KW - Drosophila melanogaster KW - Evolution KW - Selection KW - Z 05197:Habits & life histories KW - Y 25493:Insects KW - D 04659:Insects KW - Z 05199:Feeding KW - Z 05220:General KW - Y 25523:Insects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18284710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Evolution&rft.atitle=The+effects+of+selection+for+larval+behavior+on+adult+life-history+features+in+Drosophila+melanogaster&rft.au=Foley%2C+P+A%3BLuckinbill%2C+L+S&rft.aulast=Foley&rft.aufirst=P&rft.date=2001-01-01&rft.volume=55&rft.issue=12&rft.spage=2493&rft.isbn=&rft.btitle=&rft.title=Evolution&rft.issn=00143820&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Drosophila melanogaster; Feeding behavior; Selection; Evolution; Life history; Fecundity; Survival; Lipid metabolism ER - TY - JOUR T1 - Sports dermatology AN - 18143034; 5163421 AB - Sports-related skin disorders are among the most common ailments affecting adolescent athletes and may significantly impact their performance and that of their team. These conditions may be due to infection, sun exposure, trauma, inflammation or chemical changes. Knowledge of the various disorders and their unique presentations are paramount to the caring for athletes. When making decisions regarding treatment, the clinician should consider the implications for both the individual athlete and the team. JF - Adolescent Medicine AU - Adams, B B AD - Department of Dermatology, University of Cincinnati College of Medicine and Veterans Administration Medical Center, Ohio 45267-0592, USA Y1 - 2001 PY - 2001 DA - 2001 SP - 305 EP - 322 VL - 12 IS - 2 SN - 1041-3499, 1041-3499 KW - Physical Education Index KW - Skin KW - Diseases KW - Infection KW - Sports (safety) KW - Athletes KW - PE 040:Sports & Athletics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18143034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Adolescent+Medicine&rft.atitle=Sports+dermatology&rft.au=Adams%2C+B+B&rft.aulast=Adams&rft.aufirst=B&rft.date=2001-01-01&rft.volume=12&rft.issue=2&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Adolescent+Medicine&rft.issn=10413499&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Skin; Sports (safety); Diseases; Infection; Athletes ER - TY - CPAPER T1 - Regulation of the calcium receptor mRNA levels during keratinocyte differentiation AN - 42265376; 3170453 AU - Ratnam, A AU - Bikle, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42265376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulation+of+the+calcium+receptor+mRNA+levels+during+keratinocyte+differentiation&rft.au=Ratnam%2C+A%3BBikle%2C+D&rft.aulast=Ratnam&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Elsevier Science Publishing Co., 655 Avenue of the Americas, New York, NY 10010, Abstracts available. Paper No. 223 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laser irradiation decreases local recurrence in superficial bladder tumors AN - 42244866; 3154377 AU - Reddy, P P AU - Russell, D J AU - Wilbur, HJ AU - Kaufman, RP Jr AU - Stratton, S S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42244866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Laser+irradiation+decreases+local+recurrence+in+superficial+bladder+tumors&rft.au=Reddy%2C+P+P%3BRussell%2C+D+J%3BWilbur%2C+HJ%3BKaufman%2C+RP+Jr%3BStratton%2C+S+S&rft.aulast=Reddy&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Laser Medicine and Surgery, Inc., 2404 Stewart Square, Wausau, WI 54401, Abstracts available. Price $20 U.S., $30 Foreign. Poster Paper No. 359 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of pruritus: Efficacy of propofol versus sodium thiopental AN - 42226230; 3152898 AU - Melnyk, D L AU - Block, L AU - Harris, L J AU - Cohen, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42226230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Treatment+of+pruritus%3A+Efficacy+of+propofol+versus+sodium+thiopental&rft.au=Melnyk%2C+D+L%3BBlock%2C+L%3BHarris%2C+L+J%3BCohen%2C+S&rft.aulast=Melnyk&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Anesthesia Research Society, 2 Summit Park Drive, Suite 140, Cleveland, OH 44131-2553, Abstracts available. Price $15. Poster Paper No. S-316 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical and molecular pharmacology of adrenergic receptors AN - 42218497; 3152408 AU - Hoffman, B B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42218497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Clinical+and+molecular+pharmacology+of+adrenergic+receptors&rft.au=Hoffman%2C+B+B&rft.aulast=Hoffman&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Phone: (610)825-3838; Fax: (610)834-8652, Selected Abstracts available. Price $8. Audio cassette available from The Hour Recording Co., PO Box 1299, St. Petersburg, FL 33731. Price $10. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accessibility of clinical trial results and overcoming publication bias: Defining the scope of the problem - A clinician and IRB member's view AN - 42215392; 3152276 AU - Lowenthal, D T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42215392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Accessibility+of+clinical+trial+results+and+overcoming+publication+bias%3A+Defining+the+scope+of+the+problem+-+A+clinician+and+IRB+member%27s+view&rft.au=Lowenthal%2C+D+T&rft.aulast=Lowenthal&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Phone: (610)825-3838; Fax: (610)834-8652, Selected Abstracts available. Price $8. Audio cassette available from The Hour Recording Co., PO Box 1299, St. Petersburg, FL 33731. Price $10. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Do saliva concentrations predict plasma concentrations of enoxacin, ciprofloxacin, and theophylline? AN - 42215289; 3152251 AU - Zhai, S AU - Wei, X AU - Parker, B AU - Kunze, K AU - Vestal, R E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42215289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Do+saliva+concentrations+predict+plasma+concentrations+of+enoxacin%2C+ciprofloxacin%2C+and+theophylline%3F&rft.au=Zhai%2C+S%3BWei%2C+X%3BParker%2C+B%3BKunze%2C+K%3BVestal%2C+R+E&rft.aulast=Zhai&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Phone: (610)825-3838; Fax: (610)834-8652, Selected Abstracts available. Price $8. Audio cassette available from The Hour Recording Co., PO Box 1299, St. Petersburg, FL 33731. Price $10. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SNOMED analysis of three years' accessioned cases (40, 124) of a surgical pathology department: Implications for pathology-based demographic studies AN - 42211100; 3141326 AU - Berman, J J AU - Moore, G W AU - Donnelly, W H AU - Massey, J K AU - Craig, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 6500:Mathematics and Computer Science KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42211100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=SNOMED+analysis+of+three+years%27+accessioned+cases+%2840%2C+124%29+of+a+surgical+pathology+department%3A+Implications+for+pathology-based+demographic+studies&rft.au=Berman%2C+J+J%3BMoore%2C+G+W%3BDonnelly%2C+W+H%3BMassey%2C+J+K%3BCraig%2C+B&rft.aulast=Berman&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Medical Informatics Association, 4915 St. Elmo Ave., Suite 302, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacokinetics and pharmacodynamics of imiquimod AN - 42210590; 3152125 AU - Holtzman, J L AU - Finley, D K AU - Imberston, L AU - McCarville, S AU - Miller, R AU - Kvam, D C AU - Horton, V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42210590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pharmacokinetics+and+pharmacodynamics+of+imiquimod&rft.au=Holtzman%2C+J+L%3BFinley%2C+D+K%3BImberston%2C+L%3BMcCarville%2C+S%3BMiller%2C+R%3BKvam%2C+D+C%3BHorton%2C+V&rft.aulast=Holtzman&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Phone: (610)825-3838; Fax: (610)834-8652, Selected Abstracts available. Price $8. Audio cassette available from The Hour Recording Co., PO Box 1299, St. Petersburg, FL 33731. Price $10. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Continuous quality improvement methods: Application for OBRA regulations AN - 42206577; 3138140 AU - DeVito, CA AU - Persily, NA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42206577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Continuous+quality+improvement+methods%3A+Application+for+OBRA+regulations&rft.au=DeVito%2C+CA%3BPersily%2C+NA&rft.aulast=DeVito&rft.aufirst=CA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Public Health Association, Publication Sales, 1015 15th St., NW, Washington, DC 20005, USA, Abstracts available. Price $30 for 2-volume set. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural modeling of human procathepsin AN - 42206307; 3131317 AU - Sachdev, D AU - Schorey, J S AU - Lueke, H AU - Quiocho, F AU - Chirgwin, J M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42206307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Structural+modeling+of+human+procathepsin&rft.au=Sachdev%2C+D%3BSchorey%2C+J+S%3BLueke%2C+H%3BQuiocho%2C+F%3BChirgwin%2C+J+M&rft.aulast=Sachdev&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Cancer Therapy & Research Center, 8122 Datapoint Drive, Suite 600, San Antonio, TX 78229, USA. Fax: (512) 694-5221. Poster Paper No. 211 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV illness and mental distress in male and female African American clients of AIDS care and referral centers AN - 42197947; 3135962 AU - Linn, J G AU - Poku, KA AU - Cain, V A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42197947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=HIV+illness+and+mental+distress+in+male+and+female+African+American+clients+of+AIDS+care+and+referral+centers&rft.au=Linn%2C+J+G%3BPoku%2C+KA%3BCain%2C+V+A&rft.aulast=Linn&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Public Health Association, Publication Sales, 1015 15th St., NW, Washington, DC 20005, USA, Abstracts available. Price $30 for 2-volume set. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HBP1, a novel high mobility group protein, enhances myeloperoxidase promoter activity in developing myeloid cells AN - 41528182; 3431400 AU - Austin, GE AU - Lu, J-P AU - Zhao, W-G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41528182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=HBP1%2C+a+novel+high+mobility+group+protein%2C+enhances+myeloperoxidase+promoter+activity+in+developing+myeloid+cells&rft.au=Austin%2C+GE%3BLu%2C+J-P%3BZhao%2C+W-G&rft.aulast=Austin&rft.aufirst=GE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: W.B. Saunders Co., P.O. Box 628239, Orlando, FL 32862-8239, USA; phone: (800) 654-2452; fax: (800) 225-6030; email: wbspcs@harcourtbrave.com; URL: customerservice.wbsaunders.com, Abstracts available. Contact W.B. Saunders for price. Poster Paper No. 778 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurosphilis case report: Dominance of vasculitis over meningoencephalitis in determining clinical findings AN - 41511209; 3421185 AU - Masaryk, A M AU - Labadie, EL Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41511209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neurosphilis+case+report%3A+Dominance+of+vasculitis+over+meningoencephalitis+in+determining+clinical+findings&rft.au=Masaryk%2C+A+M%3BLabadie%2C+EL&rft.aulast=Masaryk&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Western Neuroradiological Society (WNS), 2210 Midwest Road, Suite 207, Oak Brook, IL 60523-8205, USA; phone: (630) 574-0220; fax: (630) 574-0661; email: asnradmn@interaccess.com, Abtracts available. Contact WNS for price. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spectrum of molecular defects in the erythroid 5-aminolevulinate synthase gene in hereditary sideroblastic anemia AN - 41493527; 3433377 AU - Bottomley, S S AU - Wise, P D AU - Wasson, E G AU - Carpenter, N J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41493527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Spectrum+of+molecular+defects+in+the+erythroid+5-aminolevulinate+synthase+gene+in+hereditary+sideroblastic+anemia&rft.au=Bottomley%2C+S+S%3BWise%2C+P+D%3BWasson%2C+E+G%3BCarpenter%2C+N+J&rft.aulast=Bottomley&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: W.B. Saunders Co., P.O. Box 628239, Orlando, FL 32862-8239, USA; phone: (800) 654-2452; fax: (800) 225-6030; email: wbspcs@harcourtbrave.com; URL: customerservice.wbsaunders.com, Abstracts available. Contact W.B. Saunders for price. Poster Paper No. 2758 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Receipt of prevention services by veterans using VHA versus non-VHA facilities AN - 41407435; 3372950 AU - Rabiner, D J AU - Branch, L G AU - Sullivan, RJ Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41407435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Receipt+of+prevention+services+by+veterans+using+VHA+versus+non-VHA+facilities&rft.au=Rabiner%2C+D+J%3BBranch%2C+L+G%3BSullivan%2C+RJ+Jr&rft.aulast=Rabiner&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Association of Teachers of Preventive Medicine, 1660 L Street NW, Suite 206, Washington, D.C. 20036, USA, Abstracts available. Price $10. Poster Paper No. PS 79 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Predicting anesthetic depth using electroencephalogram and models of drug interaction AN - 41293864; 3301510 AU - Hu, C AU - Greenwald, S AU - Chamoun, N AU - Shafer, S L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41293864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Predicting+anesthetic+depth+using+electroencephalogram+and+models+of+drug+interaction&rft.au=Hu%2C+C%3BGreenwald%2C+S%3BChamoun%2C+N%3BShafer%2C+S+L&rft.aulast=Hu&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Absorption pharmacokinetics of tacrolimus in renal transplant candidates AN - 41293598; 3301432 AU - Pak, W B AU - Lum, B L AU - Cooney, G F AU - Heifets, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41293598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Absorption+pharmacokinetics+of+tacrolimus+in+renal+transplant+candidates&rft.au=Pak%2C+W+B%3BLum%2C+B+L%3BCooney%2C+G+F%3BHeifets%2C+M&rft.aulast=Pak&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of intraperitoneal administration of methylprednisolone on pain perception in rats AN - 41284516; 3310636 AU - Donovan, K L AU - Murarescu, B M AU - Franks, W T AU - Horn, J-L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 3500:Clinical Medicine KW - U 7500:Pharmacology KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41284516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+intraperitoneal+administration+of+methylprednisolone+on+pain+perception+in+rats&rft.au=Donovan%2C+K+L%3BMurarescu%2C+B+M%3BFranks%2C+W+T%3BHorn%2C+J-L&rft.aulast=Donovan&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Anesthesia Research Society, 2 Summit Park Drive, Suite 140, Cleveland, OH 44131, Abstracts available. Paper No. S290 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Efficacy of epidural steroids in chronic low back pain patients with and without electrodiagnostic evidence of a lumbosacral radiculopathy AN - 41263954; 3286367 AU - Welsh, JE AU - Date, E S AU - Ngo, Duc T AU - Lewetzon, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41263954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Efficacy+of+epidural+steroids+in+chronic+low+back+pain+patients+with+and+without+electrodiagnostic+evidence+of+a+lumbosacral+radiculopathy&rft.au=Welsh%2C+JE%3BDate%2C+E+S%3BNgo%2C+Duc+T%3BLewetzon%2C+C&rft.aulast=Welsh&rft.aufirst=JE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Academy of Physical Medicine and Rehabilitation, 1 IBM Plaza, Suite 2500, Chicago, IL 60611, Abstracts available. Poster Paper No. 58 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Long-term application of transcutaneous electrical nerve stimulation in patients with newer pacemakers AN - 41222604; 3286510 AU - Hariman, L AU - Satcher, S M AU - Subbarao, JVS AU - Hariman, R J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41222604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Long-term+application+of+transcutaneous+electrical+nerve+stimulation+in+patients+with+newer+pacemakers&rft.au=Hariman%2C+L%3BSatcher%2C+S+M%3BSubbarao%2C+JVS%3BHariman%2C+R+J&rft.aulast=Hariman&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Academy of Physical Medicine and Rehabilitation, 1 IBM Plaza, Suite 2500, Chicago, IL 60611, Abstracts available. Poster Paper No. 201 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Parathyroid hormone (PTH) regulates the expression of the sodium-phosphate cotransporter (NaPi-4) in OK cells AN - 41190135; 3248489 AU - Lederer, ED AU - Klein, J B AU - Mathieson, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41190135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Parathyroid+hormone+%28PTH%29+regulates+the+expression+of+the+sodium-phosphate+cotransporter+%28NaPi-4%29+in+OK+cells&rft.au=Lederer%2C+ED%3BKlein%2C+J+B%3BMathieson%2C+J&rft.aulast=Lederer&rft.aufirst=ED&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 2307 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Many faces of pneumocephalus AN - 41171956; 3254403 AU - Healy, J F AU - Fu, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41171956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Many+faces+of+pneumocephalus&rft.au=Healy%2C+J+F%3BFu%2C+K&rft.aulast=Healy&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society of Nearoradiology, 2210 Midwest Road, Suite 207, Oak Brook, IL 60521, Abstracts available. Poster Paper No. SE 53 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytochrome P-450 in vitro activation of cyclophosphamide and ifosfamide AN - 41150235; 3214868 AU - Anthony, L B AU - Bennett, R E AU - Deegan, P M AU - Hande, K R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41150235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cytochrome+P-450+in+vitro+activation+of+cyclophosphamide+and+ifosfamide&rft.au=Anthony%2C+L+B%3BBennett%2C+R+E%3BDeegan%2C+P+M%3BHande%2C+K+R&rft.aulast=Anthony&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High dose megestrol acetate does not alter etoposide clearance AN - 41150204; 3214866 AU - Hande, K AU - Taplin, S AU - Krozely, M AU - Blanke, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41150204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=High+dose+megestrol+acetate+does+not+alter+etoposide+clearance&rft.au=Hande%2C+K%3BTaplin%2C+S%3BKrozely%2C+M%3BBlanke%2C+C&rft.aulast=Hande&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of forskolin-stimulated adenylyl cyclase activity by PD 81,723 AN - 41142497; 3214753 AU - Vestal, R E AU - Musser, B AU - Liu, J AU - Olson, R D AU - Mudumbi, R V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41142497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inhibition+of+forskolin-stimulated+adenylyl+cyclase+activity+by+PD+81%2C723&rft.au=Vestal%2C+R+E%3BMusser%2C+B%3BLiu%2C+J%3BOlson%2C+R+D%3BMudumbi%2C+R+V&rft.aulast=Vestal&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Real-time analysis of monophasic action potential and ECG recordings - A tool for monitoring acute drug effects on cardiac repolarization AN - 41137635; 3214710 AU - Knollmann, B C AU - Woosley, R L AU - Franz, M R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41137635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Real-time+analysis+of+monophasic+action+potential+and+ECG+recordings+-+A+tool+for+monitoring+acute+drug+effects+on+cardiac+repolarization&rft.au=Knollmann%2C+B+C%3BWoosley%2C+R+L%3BFranz%2C+M+R&rft.aulast=Knollmann&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Planning a successful and financially profitable annual workshop AN - 41132759; 3229136 AU - Peckel, J AU - Bogart, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41132759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Planning+a+successful+and+financially+profitable+annual+workshop&rft.au=Peckel%2C+J%3BBogart%2C+K&rft.aulast=Peckel&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Oncology Nursing Society, 501 Holiday Drive, Pittsburgh, PA 15220-2749, Abstracts available. Price $4. Paper No. 111 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased levels of plasma met-enkephalin associated with orthotopic liver transplantation AN - 41130693; 3218674 AU - Donovan, K L AU - Janicki, P K AU - Franks, W T AU - Striepe, VI AU - Pinson, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41130693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Increased+levels+of+plasma+met-enkephalin+associated+with+orthotopic+liver+transplantation&rft.au=Donovan%2C+K+L%3BJanicki%2C+P+K%3BFranks%2C+W+T%3BStriepe%2C+VI%3BPinson%2C+W&rft.aulast=Donovan&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Anesthesia Research Society, 2 Summit Park Drive, Suite 140, Cleveland, OH 44131-2553, Abstracts available. Paper No. S95 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Possible role of CYPs 1A1, 1A2 and 2E1 in the initiation of human oropharyngeal, esophageal and gastric cancers AN - 41119287; 3214740 AU - Holtzman, J L AU - Zhou, L X AU - Zheng, W AU - Ganz, R AU - Pihlstrom, B AU - Dansen, V AU - Park, S S AU - Potter, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41119287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Possible+role+of+CYPs+1A1%2C+1A2+and+2E1+in+the+initiation+of+human+oropharyngeal%2C+esophageal+and+gastric+cancers&rft.au=Holtzman%2C+J+L%3BZhou%2C+L+X%3BZheng%2C+W%3BGanz%2C+R%3BPihlstrom%2C+B%3BDansen%2C+V%3BPark%2C+S+S%3BPotter%2C+J&rft.aulast=Holtzman&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Newer chemotherapeutic agents for M. tuberculosis and M. avium complex infections AN - 41071711; 3196042 AU - Cynamon, M H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41071711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Newer+chemotherapeutic+agents+for+M.+tuberculosis+and+M.+avium+complex+infections&rft.au=Cynamon%2C+M+H&rft.aulast=Cynamon&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Pearson Professional, Ltd., Subscriptions Dept., PO Box 77, Harlow, Essex CM19 5BQ, UK, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preparing projections of the veteran population in each county AN - 40860212; 1112902 AU - Russell Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 6500:MATHEMATICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40860212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Preparing+projections+of+the+veteran+population+in+each+county&rft.au=Russell&rft.aulast=Russell&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Statistical Association, 806 15th Street, N.W., Washington, DC 20005 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Initial report on survey of female veterans AN - 40860172; 1112898 AU - Dienstfrey, S J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 6500:MATHEMATICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40860172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Initial+report+on+survey+of+female+veterans&rft.au=Dienstfrey%2C+S+J&rft.aulast=Dienstfrey&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Statistical Association, 806 15th Street, N.W., Washington, DC 20005 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Log-linear model for the hospitalization of veterans aged 55 and over AN - 40858724; 1112892 AU - Stockford, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 6500:MATHEMATICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Log-linear+model+for+the+hospitalization+of+veterans+aged+55+and+over&rft.au=Stockford%2C+D&rft.aulast=Stockford&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Statistical Association, 806 15th Street, N.W., Washington, DC 20005 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determinants of VA Hospital usage by aging veterans AN - 40857243; 1112883 AU - Peden, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 6500:MATHEMATICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Determinants+of+VA+Hospital+usage+by+aging+veterans&rft.au=Peden%2C+A&rft.aulast=Peden&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Statistical Association, 806 15th Street, N.W., Washington, DC 20005 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measuring hospital productivity using econometric techniques AN - 40854227; 1112914 AU - Krim, J C AU - Tsou, V T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 6500:MATHEMATICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Measuring+hospital+productivity+using+econometric+techniques&rft.au=Krim%2C+J+C%3BTsou%2C+V+T&rft.aulast=Krim&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Statistical Association, 806 15th Street, N.W., Washington, DC 20005 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of aging on the febrile response AN - 40824059; 1077914 AU - Kauffman, CA AU - Tocco-Bradley, R AU - Kluger, MJ Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40824059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+aging+on+the+febrile+response&rft.au=Kauffman%2C+CA%3BTocco-Bradley%2C+R%3BKluger%2C+MJ&rft.aulast=Kauffman&rft.aufirst=CA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Journal of Leukocyte Biology, Alan R. Liss, Inc., 41 East 11th Street, New York, NY 10003, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ultrafiltration hemodynamics in conscious dogs: effect of extracorporeal blood temperature AN - 40558356; 0499027 AU - Daugirdas, J T AU - Ing, T S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40558356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ultrafiltration+hemodynamics+in+conscious+dogs%3A+effect+of+extracorporeal+blood+temperature&rft.au=Daugirdas%2C+J+T%3BIng%2C+T+S&rft.aulast=Daugirdas&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Proceedings in: ASAIO Transactions, Sep. 1983, ASAIO Transactions Office, P.O. Box 5028, Alexandria, VA 22305, USA, Abstracts booklet (vol. 12) also available from Transactions Office for $7.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Calcium-Phosphorus Interactions in Man AN - 40448620; 0244245 AU - Spencer, H AU - Kramer, L AU - Osis, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40448620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Calcium-Phosphorus+Interactions+in+Man&rft.au=Spencer%2C+H%3BKramer%2C+L%3BOsis%2C+D&rft.aulast=Spencer&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: Journal of Nutrition, Jun. 1982, Journal of Nutrition, Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20814, ISSN: 0022-3166; Price: $8.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Ornithine Decarboxylase in Compensatory Lung Growth AN - 40446930; 0210216 AU - Thet, LA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40446930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+Ornithine+Decarboxylase+in+Compensatory+Lung+Growth&rft.au=Thet%2C+LA&rft.aulast=Thet&rft.aufirst=LA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neutrophil Alkaline Phosphatase in Zinc Deficiency and its Response to Infection AN - 40442059; 0209236 AU - Lewkow, L M AU - Prasad, A S AU - Koniuch, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40442059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neutrophil+Alkaline+Phosphatase+in+Zinc+Deficiency+and+its+Response+to+Infection&rft.au=Lewkow%2C+L+M%3BPrasad%2C+A+S%3BKoniuch%2C+D&rft.aulast=Lewkow&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pulmonary Vascular Response to Intravascular Pneumococcal Challenge in Dogs AN - 40435784; 0180161 AU - Chick, T W AU - Goldblum, SE AU - Smith, N D AU - Butler, C AU - Reed, W P AU - Skipper, B E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40435784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pulmonary+Vascular+Response+to+Intravascular+Pneumococcal+Challenge+in+Dogs&rft.au=Chick%2C+T+W%3BGoldblum%2C+SE%3BSmith%2C+N+D%3BButler%2C+C%3BReed%2C+W+P%3BSkipper%2C+B+E&rft.aulast=Chick&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Response to Intradermal Human PPD, Avian PPD and Six Recall Antigens in a Nursing Home Population AN - 40430772; 0177326 AU - Cohn, J R AU - Buckley, CE AU - Hohl, C AU - Tyson, G AU - Neish, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40430772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Response+to+Intradermal+Human+PPD%2C+Avian+PPD+and+Six+Recall+Antigens+in+a+Nursing+Home+Population&rft.au=Cohn%2C+J+R%3BBuckley%2C+CE%3BHohl%2C+C%3BTyson%2C+G%3BNeish%2C+D&rft.aulast=Cohn&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms of Arterial Hypoxemia During Rapid Movement Sleep in Patients With COPD AN - 40430265; 0178717 AU - Fletcher, E C AU - Gray, BA AU - Levin, D C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40430265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mechanisms+of+Arterial+Hypoxemia+During+Rapid+Movement+Sleep+in+Patients+With+COPD&rft.au=Fletcher%2C+E+C%3BGray%2C+BA%3BLevin%2C+D+C&rft.aulast=Fletcher&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Profile of Airway Cells in Rats Following Systemic Endotoxemia AN - 40427626; 0179408 AU - Chang, J AU - Lesser, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40427626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Profile+of+Airway+Cells+in+Rats+Following+Systemic+Endotoxemia&rft.au=Chang%2C+J%3BLesser%2C+M&rft.aulast=Chang&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mycobacterium Simiae: Clinical Features and Follow-Up of 24 Patients AN - 40427014; 0177309 AU - Bell, R C AU - Higuchi, J H AU - Donovan, W N AU - Krasnow, I AU - Johanson, W G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40427014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mycobacterium+Simiae%3A+Clinical+Features+and+Follow-Up+of+24+Patients&rft.au=Bell%2C+R+C%3BHiguchi%2C+J+H%3BDonovan%2C+W+N%3BKrasnow%2C+I%3BJohanson%2C+W+G&rft.aulast=Bell&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bacteremia Due to Streptococcus pneumoniae of Non-Vaccine Serotypes AN - 40426976; 0177232 AU - Shlaes, DM AU - Spagnuolo, P J AU - Mandell, R AU - Bass, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40426976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Bacteremia+Due+to+Streptococcus+pneumoniae+of+Non-Vaccine+Serotypes&rft.au=Shlaes%2C+DM%3BSpagnuolo%2C+P+J%3BMandell%2C+R%3BBass%2C+S&rft.aulast=Shlaes&rft.aufirst=DM&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence of a Circulating Factor in Cigarette Smoke Which Injures Epithelial Cells AN - 40426728; 0176891 AU - Merrill, W W AU - Shrader, C AU - Matthay, R A AU - Strober, W AU - Niederman, M AU - Reynolds, HY Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40426728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evidence+of+a+Circulating+Factor+in+Cigarette+Smoke+Which+Injures+Epithelial+Cells&rft.au=Merrill%2C+W+W%3BShrader%2C+C%3BMatthay%2C+R+A%3BStrober%2C+W%3BNiederman%2C+M%3BReynolds%2C+HY&rft.aulast=Merrill&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Retention of Intact Cells on Bronchoscopy Brushes After Conventional Cleaning AN - 40425268; 0176124 AU - Baker, R W AU - Jennings, C D AU - Powell, R D AU - Rehm Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40425268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Retention+of+Intact+Cells+on+Bronchoscopy+Brushes+After+Conventional+Cleaning&rft.au=Baker%2C+R+W%3BJennings%2C+C+D%3BPowell%2C+R+D%3BRehm&rft.aulast=Baker&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - "Thick" and "Thin" Alveolap Epithelial Partitions in the Adult Human Lung AN - 40425046; 0178839 AU - Takaro, T AU - Gaddy, L AU - Parra, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40425046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=%22Thick%22+and+%22Thin%22+Alveolap+Epithelial+Partitions+in+the+Adult+Human+Lung&rft.au=Takaro%2C+T%3BGaddy%2C+L%3BParra%2C+S&rft.aulast=Takaro&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stimulation of Fibroblast Proliferation by Human Interleukin 1 AN - 40424402; 0175387 AU - Postlethwaite, A E AU - Lachman, L B AU - Kang, AH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40424402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Stimulation+of+Fibroblast+Proliferation+by+Human+Interleukin+1&rft.au=Postlethwaite%2C+A+E%3BLachman%2C+L+B%3BKang%2C+AH&rft.aulast=Postlethwaite&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: Arthritis and Rheumatism, Apr. 1982, Arthritis Foundation, 3400 Peachtree Rd. N.E., Atlanta, GA 30326, Abstract No. 146 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cognitive Behavior Modification for Chronic Pain Management: An Outpatient Couples Group Approach AN - 40422511; 0186649 AU - Chaney, E F AU - Moore, JE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40422511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cognitive+Behavior+Modification+for+Chronic+Pain+Management%3A+An+Outpatient+Couples+Group+Approach&rft.au=Chaney%2C+E+F%3BMoore%2C+JE&rft.aulast=Chaney&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Behavioral Medicine National Office, P.O. Box 8530, University Station, Knoxville, TN 37996, Abstracts booklet and cassette tapes available Abstract No. B46 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Cognitive-Behavioral Strategies in the Maintenance of Exercise AN - 40421830; 0186508 AU - Dubbert, P M AU - Martin, JE AU - Raczynski, J AU - Sikora, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40421830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+Cognitive-Behavioral+Strategies+in+the+Maintenance+of+Exercise&rft.au=Dubbert%2C+P+M%3BMartin%2C+JE%3BRaczynski%2C+J%3BSikora%2C+T&rft.aulast=Dubbert&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Behavioral Medicine National Office, P.O. Box 8530, University Station, Knoxville, TN 37996, Abstracts booklet and cassette tapes available Abstract No. A15 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Persistence and Movement of Phenoxy Herbicides and TCDD in Sites Previously Used for the Long-Term Storage of Herbicide Orange AN - 40421211; 0163800 AU - Young, AL AU - Cairney, W J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40421211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Persistence+and+Movement+of+Phenoxy+Herbicides+and+TCDD+in+Sites+Previously+Used+for+the+Long-Term+Storage+of+Herbicide+Orange&rft.au=Young%2C+AL%3BCairney%2C+W+J&rft.aulast=Young&rft.aufirst=AL&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Abstracts available: Weed Science Society of America, Claude Cruse, Executive Secretary, 309 West Cark St., Champaign, IL 61820, Abstract No. 195 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Right Ventricular Ejection Fraction in Patients With Chronic Obstructive Lung Disease Using Xe-133: A Comparison With Tc-99m by Gated First-Pass Radionuclide Angiography AN - 40419888; 0175159 AU - Hooper, W AU - Nelson, T AU - Slutsky, R AU - Peters, J AU - Moser, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40419888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evaluation+of+Right+Ventricular+Ejection+Fraction+in+Patients+With+Chronic+Obstructive+Lung+Disease+Using+Xe-133%3A+A+Comparison+With+Tc-99m+by+Gated+First-Pass+Radionuclide+Angiography&rft.au=Hooper%2C+W%3BNelson%2C+T%3BSlutsky%2C+R%3BPeters%2C+J%3BMoser%2C+K&rft.aulast=Hooper&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical Course and Outcome of Lupus Nephritis as Related to Morphologic Forms in Children and Adults AN - 40418910; 0177660 AU - Al-Rawi, Z S AU - Altman, R D AU - Pardo, V AU - Perez-Stable, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40418910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Clinical+Course+and+Outcome+of+Lupus+Nephritis+as+Related+to+Morphologic+Forms+in+Children+and+Adults&rft.au=Al-Rawi%2C+Z+S%3BAltman%2C+R+D%3BPardo%2C+V%3BPerez-Stable%2C+E&rft.aulast=Al-Rawi&rft.aufirst=Z&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: Arthritis and Rheumatism, Apr. 1982, Arthritis Foundation, 3400 Peachtree Rd. N.E., Atlanta, GA 30326, Abstract No. A92 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hemodynamics of Patients With Severe Chronic Obstructive Pulmonary Disease (COPD) During Progressive Upright Exercise AN - 40418700; 0175166 AU - Mintz, H M AU - Linden, G S AU - Brown, SE AU - Light, R W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40418700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Hemodynamics+of+Patients+With+Severe+Chronic+Obstructive+Pulmonary+Disease+%28COPD%29+During+Progressive+Upright+Exercise&rft.au=Mintz%2C+H+M%3BLinden%2C+G+S%3BBrown%2C+SE%3BLight%2C+R+W&rft.aulast=Mintz&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lung Fibrosis and Emphysema: Divergent Responses to a Common Injury? AN - 40417954; 0178040 AU - Niewoehner, DE AU - Hoidal, J R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40417954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Lung+Fibrosis+and+Emphysema%3A+Divergent+Responses+to+a+Common+Injury%3F&rft.au=Niewoehner%2C+DE%3BHoidal%2C+J+R&rft.aulast=Niewoehner&rft.aufirst=DE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Radiation Controlled Focal Pharmacology in the Therapy of Experimental Epilepsy AN - 40415498; 0141449 AU - Remler, M P AU - Marcussen, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40415498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Radiation+Controlled+Focal+Pharmacology+in+the+Therapy+of+Experimental+Epilepsy&rft.au=Remler%2C+M+P%3BMarcussen%2C+W&rft.aulast=Remler&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 29.17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cathepsin B and Prolyl Endopeptidase Levels in Rat Pulmonary Macrophages: Comparison With Levels in Baseline and Stimulated Peritoneal Macrophages AN - 40412034; 0174757 AU - Lesser, M AU - Chang, J AU - Orlowski, J AU - Kilburn, KH AU - Orlowski, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40412034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cathepsin+B+and+Prolyl+Endopeptidase+Levels+in+Rat+Pulmonary+Macrophages%3A+Comparison+With+Levels+in+Baseline+and+Stimulated+Peritoneal+Macrophages&rft.au=Lesser%2C+M%3BChang%2C+J%3BOrlowski%2C+J%3BKilburn%2C+KH%3BOrlowski%2C+M&rft.aulast=Lesser&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acute Tubular Necrosis in Hepatorenal Syndrome: An Electron Microscopic Study AN - 40411422; 0142498 AU - Mandal, A K AU - Lansing, M AU - Fahmy, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40411422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Acute+Tubular+Necrosis+in+Hepatorenal+Syndrome%3A+An+Electron+Microscopic+Study&rft.au=Mandal%2C+A+K%3BLansing%2C+M%3BFahmy%2C+A&rft.aulast=Mandal&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Abstracts booklet available: American Society of Clinical Pathologists, 2100 West Harrison St., Chicago, IL 60612, Abstract No. 20 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Extracellular Potassium on the Excitability of the Parallel Fibers AN - 40410206; 0141099 AU - Malenka, R C AU - Kocsis, J D AU - Waxman, S G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40410206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+Extracellular+Potassium+on+the+Excitability+of+the+Parallel+Fibers&rft.au=Malenka%2C+R+C%3BKocsis%2C+J+D%3BWaxman%2C+S+G&rft.aulast=Malenka&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 26.7 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Behavioral States After Brainstem Transection at the Medullary Level AN - 40408904; 0143736 AU - Siegel, J M AU - Nienhuis, R AU - Tomaszewski, K AU - Wheeler, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40408904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Behavioral+States+After+Brainstem+Transection+at+the+Medullary+Level&rft.au=Siegel%2C+J+M%3BNienhuis%2C+R%3BTomaszewski%2C+K%3BWheeler%2C+R&rft.aulast=Siegel&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 79.2 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Direct Immunofluorescence Staining of Sputum for Legionelle pneumophila AN - 40407221; 0142246 AU - Renner, ED AU - Lattimer, G L AU - Zimmerman, J C AU - Tseng, CH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40407221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Direct+Immunofluorescence+Staining+of+Sputum+for+Legionelle+pneumophila&rft.au=Renner%2C+ED%3BLattimer%2C+G+L%3BZimmerman%2C+J+C%3BTseng%2C+CH&rft.aulast=Renner&rft.aufirst=ED&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Abstracts booklet available: American Society of Clinical Pathologists, 2100 West Harrison St., Chicago, IL 60612, Abstract No. P-19 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Autofluorescence of Fungi: an Aid to Detection in Tissue Sections AN - 40404058; 0142335 AU - Mann, J L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40404058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Autofluorescence+of+Fungi%3A+an+Aid+to+Detection+in+Tissue+Sections&rft.au=Mann%2C+J+L&rft.aulast=Mann&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Abstracts booklet available: American Society of Clinical Pathologists, 2100 West Harrison St., Chicago, IL 60612, Abstract No. P-34 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of unsaturated fatty acids on lipoprotein oxidation and induction of proinflammatory responses AN - 39260352; 3524093 AU - Reaven, P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39260352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+unsaturated+fatty+acids+on+lipoprotein+oxidation+and+induction+of+proinflammatory+responses&rft.au=Reaven%2C+P&rft.aulast=Reaven&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Oil Chemists' Society, AOCS Meetings and Exhibits Department, P.O. Box 3489, Champaign, Il 61826-3489, USA; phone: 1-217-359-2344; fax: 1-217-351-8091; email: meetings@aocs.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Chronic ethanol exposure - Comparisons of human and experimental data AN - 39188274; 3525808 AU - Cook, R T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39188274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Chronic+ethanol+exposure+-+Comparisons+of+human+and+experimental+data&rft.au=Cook%2C+R+T&rft.aulast=Cook&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Peroxidase activity of the extracellular superoxide dismutase AN - 39149953; 3516996 AU - Hink, U AU - Fukai, T AU - Wendt, M AU - Parthasarathy, S AU - Harrison, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39149953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Peroxidase+activity+of+the+extracellular+superoxide+dismutase&rft.au=Hink%2C+U%3BFukai%2C+T%3BWendt%2C+M%3BParthasarathy%2C+S%3BHarrison%2C+D&rft.aulast=Hink&rft.aufirst=U&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Elsevier Science, Inc., 655 Avenue of the Americas, New York, NY 10010-5107; phone: 212-633-3730; fax: 212-633-3680; email: usinfo-f@elsevier.com; URL: www.elsevier.com, Full Abstracts Available. N1 - Last updated - 2011-10-26 ER - TY - JOUR T1 - Dimerization interfaces of v-erbA homodimers and heterodimers with retinoid X receptor alpha. AN - 72477831; 11018031 AB - The oncoprotein v-ErbA, a member of the zinc finger transcription factor superfamily, is a mutated version of thyroid hormone receptor alpha1 that is virtually incapable of binding T3. v-ErbA and other members of this family can bind as homodimers and heterodimers with retinoid X receptors to specific DNA sequences arranged as direct, inverted, or everted repeats. At least two regions in the C-terminal domain, the I box (10 and 11 helices in v-ErbA and thyroid hormone receptors) and the 20-amino acid region are involved in dimerization. However, it has not been entirely understood how these receptors dimerize on differently oriented core motifs and whether the domain(s) responsible for homodimerization and heterodimerization are identical. Therefore, deletions of the entire 20-amino acid region, the 10 helix, the 11 helix, and point mutations within these regions of v-ErbA were made by site-directed mutagenesis. The mutant proteins were tested for their ability to form v-ErbA homodimers and heterodimers with retinoid X receptor alpha on differently oriented core motifs by electrophoretic mobility shift assay. Transient transfections were performed to determine the dominant negative activity of the v-ErbA mutants. The data indicate that different dimerization interfaces are used for v-ErbA homodimerization and heterodimerization with retinoid X receptor alpha, and different dimerization interfaces are used on differently oriented core motifs. The data are of general interest because the information improves our understanding of the role of these dimerization interfaces in the mechanism of action not only of v-ErbA but also of other members of the superfamily. JF - The Journal of biological chemistry AU - Shen, Q AU - Subauste, J S AD - Division of Endocrinology and Metabolism, University of Mississippi Medical Center and G. V. Montgomery Veterans Administration Medical Center, Jackson, Mississippi 39216, USA. Y1 - 2000/12/29/ PY - 2000 DA - 2000 Dec 29 SP - 41018 EP - 41027 VL - 275 IS - 52 SN - 0021-9258, 0021-9258 KW - Oncogene Proteins v-erbA KW - 0 KW - Receptors, Retinoic Acid KW - Retinoid X Receptors KW - Transcription Factors KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Protein Structure, Secondary KW - Dimerization KW - DNA -- metabolism KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Response Elements KW - Oncogene Proteins v-erbA -- chemistry KW - Receptors, Retinoic Acid -- chemistry KW - Transcription Factors -- chemistry KW - Oncogene Proteins v-erbA -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72477831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Dimerization+interfaces+of+v-erbA+homodimers+and+heterodimers+with+retinoid+X+receptor+alpha.&rft.au=Shen%2C+Q%3BSubauste%2C+J+S&rft.aulast=Shen&rft.aufirst=Q&rft.date=2000-12-29&rft.volume=275&rft.issue=52&rft.spage=41018&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-26 N1 - Date created - 2001-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reemergence of tardive dyskinesia after discontinuation of clozapine treatment. AN - 72483253; 11120422 AB - Tardive dyskinesia (TD) continues to be a significant health problem and a serious limitation to neuroleptic medication treatment. Clozapine treatment may reduce the severity of TD but it is unclear wether the medication temporarily suppresses symptoms or leads to a sustain resolution of the disorder. Herein we describe two cases with severe TD which clozapine had to be discontinued. These cases suggest that clozapine provides a temporary suppression of TD rather than a permanent resolution of the disorder. JF - Schizophrenia research AU - Yovtcheva, S P AU - Stanley-Tilt, C AU - Moles, J K AD - University of Virginia School of Medicine, Roanoke Salem Psychiatric Medicine Residency Program, Department of Psychiatry (116A7), VA Medical Center, Salem, VA 24153, USA. yovtcheva.sonia_r@salem.va.gov Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 107 EP - 109 VL - 46 IS - 2-3 SN - 0920-9964, 0920-9964 KW - Serotonin Antagonists KW - 0 KW - Clozapine KW - J60AR2IKIC KW - Index Medicus KW - Severity of Illness Index KW - Humans KW - Aged KW - Middle Aged KW - Time Factors KW - Recurrence KW - Male KW - Serotonin Antagonists -- therapeutic use KW - Clozapine -- therapeutic use KW - Dyskinesia, Drug-Induced -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72483253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+research&rft.atitle=Reemergence+of+tardive+dyskinesia+after+discontinuation+of+clozapine+treatment.&rft.au=Yovtcheva%2C+S+P%3BStanley-Tilt%2C+C%3BMoles%2C+J+K&rft.aulast=Yovtcheva&rft.aufirst=S&rft.date=2000-12-15&rft.volume=46&rft.issue=2-3&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+research&rft.issn=09209964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-02 N1 - Date created - 2001-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neoadjuvant therapy for organ preservation in head and neck cancer. AN - 85357095; pmid-11129024 AB - OBJECTIVES/HYPOTHESIS: We designed two sequential trials of induction chemotherapy followed by definitive radiation in patients with potentially resectable head and neck cancer to determine whether organ preservation is feasible without apparent compromise of survival Study Design Both trials were Phase II studies. METHODS: Two clinical trials were conducted sequentially at the University of Michigan. Fifty-two patients enrolled in the first study and were treated with a planned three cycles of carboplatin and 5-fluorouracil. Patients who achieved at least 50% reduction in the size of the primary tumor received definitive radiation therapy, to a dose of 6600 to 7380 cGy. Patients with minimal response or progression had immediate salvage surgery. Thirty-seven patients enrolled in the second trial, in which the chemotherapy consisted of carboplatin, 5-fluororuracil, and leukovorin. Responders were treated with accelerated radiation therapy, to a total dose of 7120 cGy delivered in 41 fractions over 5.5 weeks. RESULTS: Toxicity and response were similar in both trials; therefore, the results are reported first separately and then combined for all 89 patients. Tumor sites included: oropharynx, 55 patients; hypopharynx, 34 patients. Eighty-three percent of patients tolerated all three cycles of chemotherapy and toxicity was mild. Response to chemotherapy was: 48% complete response at the primary tumor site, and 34% partial response at the primary tumor site. Initial organ preservation at individual tumor sites was: oropharynx, 58%; hypopharynx, 59%. Median survival was 28 months, and survival at 3 and 5 years was 40% and 24%, respectively. CONCLUSIONS: These two regimens were well tolerated, and survival did not appear to be compromised by organ preservation treatment compared with historical controls. This approach warrants further investigation, particularly in those patients for whom surgery could be functionally debilitating. JF - The Laryngoscope AU - Urba, S G AU - Wolf, G T AU - Bradford, C R AU - Thornton, A F AU - Eisbruch, A AU - Terrell, J E AU - Carpenter, V AU - Miller, T AU - Tang, G AU - Strawderman, M AD - Department of Internal Medicine, University of Michigan Comprehensive Cancer Center and Veterans Administration Medical Center, Ann Arbor, 48109-0922, USA. surba@umich.edu Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 2074 EP - 2080 VL - 110 IS - 12 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Disease-Free Survival KW - Humans KW - Aged KW - Carboplatin -- therapeutic use KW - Fluorouracil -- therapeutic use KW - Aged, 80 and over KW - Radiotherapy Dosage KW - Adult KW - Middle Aged KW - Female KW - Male KW - Chemotherapy, Adjuvant KW - Survival Analysis KW - Leucovorin -- therapeutic use KW - Oropharyngeal Neoplasms -- surgery KW - Oropharyngeal Neoplasms -- radiotherapy KW - Hypopharyngeal Neoplasms -- surgery KW - Carcinoma, Squamous Cell -- mortality KW - Oropharyngeal Neoplasms -- mortality KW - Carcinoma, Squamous Cell -- surgery KW - Oropharyngeal Neoplasms -- drug therapy KW - Hypopharyngeal Neoplasms -- drug therapy KW - Hypopharyngeal Neoplasms -- mortality KW - Hypopharyngeal Neoplasms -- radiotherapy KW - Antineoplastic Agents -- therapeutic use KW - Carcinoma, Squamous Cell -- drug therapy KW - Carcinoma, Squamous Cell -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85357095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Neoadjuvant+therapy+for+organ+preservation+in+head+and+neck+cancer.&rft.au=Urba%2C+S+G%3BWolf%2C+G+T%3BBradford%2C+C+R%3BThornton%2C+A+F%3BEisbruch%2C+A%3BTerrell%2C+J+E%3BCarpenter%2C+V%3BMiller%2C+T%3BTang%2C+G%3BStrawderman%2C+M&rft.aulast=Urba&rft.aufirst=S&rft.date=2000-12-01&rft.volume=110&rft.issue=12&rft.spage=2074&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Gastric-juice ammonia assay for diagnosis of Helicobacter pylori infection and the relationship of ammonia concentration to gastritis severity. AN - 85353398; pmid-11151868 AB - OBJECTIVES: To determine the test characteristics of gastric-juice ammonia concentration as measured by an ion-selective electrode and a rapid ammonia detection device for the diagnosis of Helicobacter pylori infection and to assess the relationship between gastric-juice ammonia concentration and the severity of gastritis. METHODS: Patients undergoing upper endoscopy had collection of gastric juice that was tested for ammonia using an ion-selective electrode and a rapid ammonia assay device that uses a pH-indicating membrane. A receiver operating characteristic curve was calculated for ammonia concentration. Severity of gastritis was graded using the Sydney classification (1) and correlated to gastric-juice ammonia concentration. Patients also underwent H. pylori testing by IgG serology, rapid urease testing, and histological special stain. Ammonia testing results were compared with a reference standard of two of three positive tests and with a second reference standard of a positive serology. RESULTS: 73 patients underwent endoscopy and collection of gastric juice. The receiver operating characteristic curve indicated an optimal cutoff value of 5 mM, yielding a sensitivity of 67%, specificity of 93%, positive predictive value of 67%, and negative predictive value of 93% (compared with the combined reference standard). The rapid NH3-testing device yielded a sensitivity of 83%, specificity 63%, positive predictive value 31%, and negative predictive value 95%. The severity of neutrophilic (p = 0.001) and mononuclear cell (p = 0.003) infiltration were significantly correlated with gastric-juice ammonia concentration. CONCLUSIONS: Measurement of gastric-juice ammonia concentration by ion-selective electrode or rapid detection device is a relatively insensitive and nonspecific means of H. pylori diagnosis. Gastritis severity increases with gastric-juice ammonia concentration. JF - The American journal of gastroenterology AU - Kearney, D J AU - Ritchie, K AU - Peacock, J S AD - Department of Medicine, Seattle Veterans Administration Medical Center, Washington 98108, USA Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 3399 EP - 3403 VL - 95 IS - 12 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Sensitivity and Specificity KW - Severity of Illness Index KW - Gastroscopy KW - ROC Curve KW - Humans KW - Gastritis -- diagnosis KW - Middle Aged KW - Predictive Value of Tests KW - Gastritis -- microbiology KW - Male KW - Female KW - Ion-Selective Electrodes KW - Helicobacter Infections -- diagnosis KW - Helicobacter pylori KW - Ammonia -- analysis KW - Gastric Juice -- chemistry KW - Helicobacter Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85353398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Gastric-juice+ammonia+assay+for+diagnosis+of+Helicobacter+pylori+infection+and+the+relationship+of+ammonia+concentration+to+gastritis+severity.&rft.au=Kearney%2C+D+J%3BRitchie%2C+K%3BPeacock%2C+J+S&rft.aulast=Kearney&rft.aufirst=D&rft.date=2000-12-01&rft.volume=95&rft.issue=12&rft.spage=3399&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Prasterone (DHEA) and mania. AN - 72516795; 11144700 AB - To inform clinicians and investigators of the potential for severe mania in conjunction with the use of prasterone (DHEA; dehydroepiandrosterone). A 31-year-old Hispanic man was admitted on a 72-hour observation period from a neighboring hospital after threatening to kill himself, family members, and a friend. A loaded rifle was found under his bed. The family confirmed that he had begun using DHEA several weeks prior to his mood and behavioral changes. He denied any past violence, but had once been given an unsubstantiated diagnosis of bipolar disorder. He used alcohol episodically, and had difficulties controlling his anger while intoxicated. Although he improved with valproate, his threats of homicide led to involuntary commitment. Several studies and case reports strongly suggest that anabolic steroids can induce significant psychiatric difficulties, including mania, impaired cognition, and overt psychosis. Although the Food and Drug Administration noted in 1985 that the efficacy and safety of DHEA were never confirmed, the agent continues to be sold over the counter. Several groups have used DHEA in the treatment of AIDS, memory loss, and depression, but reported no serious adverse events; however, recent studies indicate that severe psychiatric symptoms can develop in a subset of users. Although uncertain, potential risk factors include high doses of DHEA; history of mood disorder; concurrent use of alcohol, street drugs, or antidepressants; and cytochrome P450 polymorphisms. The use of DHEA in those under age 35 years may be especially risky, as endogenous DHEA concentrations peak at age 20-30 years. Those using or investigating DHEA should be cognizant of the potential for severe psychiatric complications. JF - The Annals of pharmacotherapy AU - Dean, C E AD - Minneapolis Veteran's Affairs Medical Center, University of Minnesota Department of Psychiatry, 55417, USA. charles.dean@med.va.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1419 EP - 1422 VL - 34 IS - 12 SN - 1060-0280, 1060-0280 KW - Adjuvants, Immunologic KW - 0 KW - Dehydroepiandrosterone KW - 459AG36T1B KW - Index Medicus KW - Humans KW - Adult KW - Adjuvants, Immunologic -- adverse effects KW - Male KW - Dehydroepiandrosterone -- adverse effects KW - Bipolar Disorder -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72516795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Prasterone+%28DHEA%29+and+mania.&rft.au=Dean%2C+C+E&rft.aulast=Dean&rft.aufirst=C&rft.date=2000-12-01&rft.volume=34&rft.issue=12&rft.spage=1419&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-08 N1 - Date created - 2000-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Omeprazole 40 mg once a day is equally effective as lansoprazole 30 mg twice a day in symptom control of patients with gastro-oesophageal reflux disease (GERD) who are resistant to conventional-dose lansoprazole therapy-a prospective, randomized, multi-centre study. AN - 72484821; 11121907 AB - Comparative studies of omeprazole and lansoprazole are scarce and even scarcer are comparisons of higher doses. Most of the comparative studies have assessed the effect of the two proton pump inhibitors (PPIs) on gastric acid secretion or gastric pH. Few studies have compared clinical end-points such as oesophageal healing and symptom control. To determine the clinical efficacy of omeprazole 40 mg daily as compared to lansoprazole 30 mg twice a day in symptom control of patients with severe symptomatic GERD. Ninety-six patients who failed a standard dose of lansoprazole (30 mg once daily), were enrolled in a prospective fashion from three VA medical centres and were randomized to receive 6 weeks of either omeprazole 40 mg daily or lansoprazole 30 mg twice daily. Patients reported daily on symptom severity and frequency, antacid consumption and side-effects. Forty-six patients received omeprazole and 44 lansoprazole. Although not statistically significant, there was a consistent trend of better symptom control in the omeprazole group for daytime and night-time heartburn and acid regurgitation. There was no statistical difference between the two groups in mean antacid consumption overall and at the end of each of the 6 weeks of the study. In addition, there was no significant difference in the overall frequency of side-effects between the two groups nor for each individual side-effect. Omeprazole 40 mg once daily is equally effective and tolerated as lansoprazole 30 mg twice daily in symptom control of patients with GERD. JF - Alimentary pharmacology & therapeutics AU - Fass, R AU - Murthy, U AU - Hayden, C W AU - Malagon, I B AU - Pulliam, G AU - Wendel, C AU - Kovacs, T O AD - Section of Gastroenterology, Department of Medicine, Tucson VA Medical Center, Tucson, Arizona, USA. Ronnie.Fass@Med.VA.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1595 EP - 1603 VL - 14 IS - 12 SN - 0269-2813, 0269-2813 KW - 2-Pyridinylmethylsulfinylbenzimidazoles KW - 0 KW - Enzyme Inhibitors KW - Lansoprazole KW - 0K5C5T2QPG KW - Omeprazole KW - KG60484QX9 KW - Index Medicus KW - Drug Administration Schedule KW - Prospective Studies KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Enzyme Inhibitors -- administration & dosage KW - Omeprazole -- adverse effects KW - Omeprazole -- administration & dosage KW - Omeprazole -- analogs & derivatives KW - Gastroesophageal Reflux -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72484821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alimentary+pharmacology+%26+therapeutics&rft.atitle=Omeprazole+40+mg+once+a+day+is+equally+effective+as+lansoprazole+30+mg+twice+a+day+in+symptom+control+of+patients+with+gastro-oesophageal+reflux+disease+%28GERD%29+who+are+resistant+to+conventional-dose+lansoprazole+therapy-a+prospective%2C+randomized%2C+multi-centre+study.&rft.au=Fass%2C+R%3BMurthy%2C+U%3BHayden%2C+C+W%3BMalagon%2C+I+B%3BPulliam%2C+G%3BWendel%2C+C%3BKovacs%2C+T+O&rft.aulast=Fass&rft.aufirst=R&rft.date=2000-12-01&rft.volume=14&rft.issue=12&rft.spage=1595&rft.isbn=&rft.btitle=&rft.title=Alimentary+pharmacology+%26+therapeutics&rft.issn=02692813&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-18 N1 - Date created - 2001-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reduced inhibition in an animal model of cortical dysplasia. AN - 72451548; 11102503 AB - Cortical dysplasia has a strong association with epilepsy in humans, but the underlying mechanisms for this are poorly understood. In utero irradiation of rats produces diffuse cortical dysplasia and neuronal heterotopia in the neocortex and hippocampus. Using in vitro neocortical slices, whole-cell patch-clamp recordings were obtained from pyramidal neurons in dysplastic cortex and control neocortex. Spontaneous IPSCs were reduced in amplitude (35%) and frequency (70%) in pyramidal cells from dysplastic cortex. Miniature IPSCs were reduced in frequency (66%) in dysplastic cortex. Two additional measures of cortical inhibition, monosynaptic evoked IPSCs and paired pulse depression of evoked EPSCs, were also impaired in dysplastic cortex. Spontaneous EPSCs were increased in amplitude (42%) and frequency (77%) in dysplastic cortex, but miniature EPSCs were not different between the two groups. These data demonstrate significant physiological impairment in inhibitory synaptic transmission in experimental cortical dysplasia. This supports previous immunohistochemical findings in this model and observations in humans of a reduction in the density of inhibitory interneurons in dysplastic cortex. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Zhu, W J AU - Roper, S N AD - Department of Neurological Surgery, University of Florida, and Malcolm Randall Veterans Administration Medical Center, Gainesville, Florida 32610-0265, USA. Y1 - 2000/12/01/ PY - 2000 DA - 2000 Dec 01 SP - 8925 EP - 8931 VL - 20 IS - 23 KW - Excitatory Amino Acid Antagonists KW - 0 KW - GABA-A Receptor Antagonists KW - Tetrodotoxin KW - 4368-28-9 KW - Index Medicus KW - Animals KW - Synaptic Transmission -- radiation effects KW - Gamma Rays KW - Evoked Potentials -- radiation effects KW - Choristoma -- pathology KW - Disease Models, Animal KW - Choristoma -- etiology KW - Electric Stimulation KW - Maternal Exposure KW - Pregnancy KW - Excitatory Amino Acid Antagonists -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Patch-Clamp Techniques KW - Excitatory Postsynaptic Potentials -- drug effects KW - Excitatory Postsynaptic Potentials -- radiation effects KW - In Vitro Techniques KW - Cell Membrane -- metabolism KW - Tetrodotoxin -- pharmacology KW - Female KW - Pyramidal Cells -- physiopathology KW - Neocortex -- metabolism KW - Neocortex -- abnormalities KW - Pyramidal Cells -- radiation effects KW - Neural Inhibition -- radiation effects KW - Pyramidal Cells -- metabolism KW - Neocortex -- physiopathology KW - Neocortex -- pathology KW - Neocortex -- radiation effects KW - Abnormalities, Radiation-Induced -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72451548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Reduced+inhibition+in+an+animal+model+of+cortical+dysplasia.&rft.au=Zhu%2C+W+J%3BRoper%2C+S+N&rft.aulast=Zhu&rft.aufirst=W&rft.date=2000-12-01&rft.volume=20&rft.issue=23&rft.spage=8925&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-08 N1 - Date created - 2001-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vocational rehabilitation outcomes of veterans with substance use disorders in a partial hospitalization program. AN - 72434816; 11097656 AB - The authors examined factors that influenced the employment rates of 529 veterans with severe alcohol and other substance use disorders who were being treated at an addictions partial hospitalization program. The employment rate was significantly higher for veterans who completed the hospitalization program, participated in a Veterans Industries work-for-pay program, and received drug-free supportive housing. JF - Psychiatric services (Washington, D.C.) AU - Kerrigan, A J AU - Kaough, J E AU - Wilson, B L AU - Wilson, J V AU - Boeringa, J A AU - Monga, T N AD - Psychology Service, VA Medical Center, Houston, Texas 77030, USA. kerrigan.anthonyj@med.va.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1570 EP - 1572 VL - 51 IS - 12 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - Hospitalization KW - Humans KW - Adult KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Male KW - Ambulatory Care KW - Veterans -- psychology KW - Rehabilitation, Vocational KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72434816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Vocational+rehabilitation+outcomes+of+veterans+with+substance+use+disorders+in+a+partial+hospitalization+program.&rft.au=Kerrigan%2C+A+J%3BKaough%2C+J+E%3BWilson%2C+B+L%3BWilson%2C+J+V%3BBoeringa%2C+J+A%3BMonga%2C+T+N&rft.aulast=Kerrigan&rft.aufirst=A&rft.date=2000-12-01&rft.volume=51&rft.issue=12&rft.spage=1570&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-26 N1 - Date created - 2001-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relation of family history of suicide to suicide attempts in alcoholics. AN - 72431327; 11097978 AB - This study was an examination of whether a family history of suicide is associated with attempts at suicide among alcoholics. A consecutive series of 333 alcoholics were interviewed about whether or not they had ever attempted suicide and about their family history of suicide. Compared with alcoholics who had never attempted suicide, significantly more of the alcoholics who had attempted suicide reported that a first- or second-degree relative had committed suicide. A family history of suicide may indicate that an alcoholic has a higher risk of attempting suicide. JF - The American journal of psychiatry AU - Roy, A AD - Psychiatry Service, Department of Veteran Affairs, New Jersey Healthcare System, East Orange, 07019, USA. alec.roy@med.va.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 2050 EP - 2051 VL - 157 IS - 12 SN - 0002-953X, 0002-953X KW - Abridged Index Medicus KW - Index Medicus KW - Risk Factors KW - Humans KW - Male KW - Female KW - Suicide, Attempted -- statistics & numerical data KW - Suicide, Attempted -- psychology KW - Alcoholism -- diagnosis KW - Family KW - Suicide -- statistics & numerical data KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72431327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Relation+of+family+history+of+suicide+to+suicide+attempts+in+alcoholics.&rft.au=Roy%2C+A&rft.aulast=Roy&rft.aufirst=A&rft.date=2000-12-01&rft.volume=157&rft.issue=12&rft.spage=2050&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-01 N1 - Date created - 2000-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inflammatory properties of IgG modified by oxygen radicals and peroxynitrite. AN - 72430223; 11086095 AB - In inflammatory arthritis, there is evidence indicating that the affected tissues produce large amounts of oxygen-free radicals and NO. Herein, we examine the biologic effects of exposure of IgG to hypochlorous acid (HOCl) and peroxynitrite (ONOO). The concentrations of IgG modified by chlorination and nitrosation were measured in synovial fluids from inflammatory and noninflammatory arthritis. Human IgG was exposed to increasing concentrations of HOCl and ONOO, and the resulting products were tested for complement component binding; binding to FcgammaRI; activation of polymorphonuclear neutrophils; effect on the Ab-combining site of Abs; and in vivo inflammatory activity in a rabbit model of acute arthritis. Rheumatoid synovial fluids contained significantly greater concentrations of nitrosated and chlorinated IgG compared with ostearthritic specimens. In vitro exposure of human IgG to HOCl and ONOO resulted in a concentration-dependent decrease in C3 and C1q fixation. The decrease in Fc domain-dependent biologic functions was confirmed by competitive binding studies to the FcgammaRI of U937 cells. HOCl-treated IgG monomer was 10 times less effective in competing for binding compared with native IgG, and ONOO-treated IgG was 2.5 times less effective. The modified IgGs were also ineffective in inducing synthesis of H(2)O(2) by human PMN. The Ag-binding domains of IgG also showed a concentration-dependent decrease in binding to Ag. The ability of the modified IgGs to induce acute inflammation in rabbit knees decreased 20-fold as gauged by the intensity of the inflammatory cell exudates. These studies clarify the modulating role of biological oxidants in inflammatory processes in which Ag-autoantibody reactions and immune complex pathogenesis may play an important role. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Uesugi, M AU - Yoshida, K AU - Jasin, H E AD - Division of Rheumatology and Clinical Immunology, Teresa Scheu Rheumatoid Arthritis Research Laboratory, Department of Internal Medicine, University of Arkansas for Medical Sciences, and Veterans Administration Medical Center, Little Rock, AR, USA. Y1 - 2000/12/01/ PY - 2000 DA - 2000 Dec 01 SP - 6532 EP - 6537 VL - 165 IS - 11 SN - 0022-1767, 0022-1767 KW - Complement C3 KW - 0 KW - Free Radicals KW - Immunoglobulin G KW - Nitrates KW - Receptors, IgG KW - Serum Albumin, Bovine KW - peroxynitric acid KW - 26404-66-0 KW - 3-nitrotyrosine KW - 3604-79-3 KW - Tyrosine KW - 42HK56048U KW - Hypochlorous Acid KW - 712K4CDC10 KW - Complement C1q KW - 80295-33-6 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Oxygen KW - S88TT14065 KW - Abridged Index Medicus KW - Index Medicus KW - Gout -- immunology KW - Acute Disease KW - Animals KW - Gout -- metabolism KW - Neutrophils -- immunology KW - Humans KW - Receptors, IgG -- metabolism KW - Synovial Fluid -- immunology KW - Arthritis, Rheumatoid -- metabolism KW - Neutrophils -- metabolism KW - Oxidation-Reduction KW - Hypochlorous Acid -- immunology KW - Osteoarthritis -- metabolism KW - Arthritis, Experimental -- metabolism KW - Serum Albumin, Bovine -- immunology KW - Osteoarthritis -- immunology KW - Serum Albumin, Bovine -- metabolism KW - Synovial Fluid -- metabolism KW - Male KW - Hypochlorous Acid -- metabolism KW - Arthritis, Experimental -- immunology KW - Hydrogen Peroxide -- metabolism KW - Rabbits KW - Complement C1q -- metabolism KW - Complement C3 -- metabolism KW - Binding Sites, Antibody KW - Arthritis, Rheumatoid -- immunology KW - Female KW - Tyrosine -- immunology KW - Oxygen -- metabolism KW - Nitrates -- metabolism KW - Tyrosine -- metabolism KW - Tyrosine -- analogs & derivatives KW - Immunoglobulin G -- toxicity KW - Immunoglobulin G -- metabolism KW - Free Radicals -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72430223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Inflammatory+properties+of+IgG+modified+by+oxygen+radicals+and+peroxynitrite.&rft.au=Uesugi%2C+M%3BYoshida%2C+K%3BJasin%2C+H+E&rft.aulast=Uesugi&rft.aufirst=M&rft.date=2000-12-01&rft.volume=165&rft.issue=11&rft.spage=6532&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2000-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Randomized comparison of linezolid (PNU-100766) versus oxacillin-dicloxacillin for treatment of complicated skin and soft tissue infections. AN - 72419615; 11083648 AB - This randomized, double-blind, multicenter trial compared the efficacy and safety of linezolid, an oxazolidinone, with those of oxacillin-dicloxacillin in patients with complicated skin and soft tissue infections. A total of 826 hospitalized adult patients were randomized to receive linezolid (600 mg intravenously [i.v.]) every 12 h or oxacillin (2 g i.v.) every 6 h; following sufficient clinical improvement, patients were switched to the respective oral agents (linezolid [600 mg orally] every 12 h or dicloxacillin [500 mg orally] every 6 hours). Primary efficacy variables were clinical cure rates in both the intent-to-treat (ITT) population and clinically evaluable (CE) patients and microbiological success rate in microbiologically evaluable (ME) patients. Safety and tolerability were evaluated in the ITT population. Demographics and baseline characteristics were similar across treatment groups in the 819 ITT patients. In the ITT population, the clinical cure rates were 69.8 and 64.9% in the linezolid and oxacillin-dicloxacillin groups, respectively (P = 0.141; 95% confidence interval -1.58 to 11. 25). In 298 CE linezolid-treated patients, the clinical cure rate was 88.6%, compared with a cure rate of 85.8% in 302 CE patients who received oxacillin-dicloxacillin. In 143 ME linezolid-treated patients, the microbiological success rate was 88.1%, compared with a success rate of 86.1% in 151 ME patients who received oxacillin-dicloxacillin. Both agents were well tolerated; most adverse events were of mild-to-moderate intensity. No serious drug-related adverse events were reported in the linezolid group. These data support the use of linezolid for the treatment of adults with complicated skin and soft tissue infections. JF - Antimicrobial agents and chemotherapy AU - Stevens, D L AU - Smith, L G AU - Bruss, J B AU - McConnell-Martin, M A AU - Duvall, S E AU - Todd, W M AU - Hafkin, B AD - Infectious Diseases Section, Veterans Administration Medical Center, Boise, Idaho, USA. dlsteven@primenet.com Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 3408 EP - 3413 VL - 44 IS - 12 SN - 0066-4804, 0066-4804 KW - Acetamides KW - 0 KW - Anti-Infective Agents KW - Oxazolidinones KW - Penicillins KW - Dicloxacillin KW - COF19H7WBK KW - Linezolid KW - ISQ9I6J12J KW - Oxacillin KW - UH95VD7V76 KW - Index Medicus KW - Drug Therapy, Combination KW - Anti-Infective Agents -- therapeutic use KW - Anti-Infective Agents -- adverse effects KW - Double-Blind Method KW - Humans KW - Treatment Outcome KW - Penicillins -- therapeutic use KW - Middle Aged KW - Penicillins -- adverse effects KW - Male KW - Female KW - Soft Tissue Infections -- drug therapy KW - Skin Diseases, Bacterial -- drug therapy KW - Dicloxacillin -- therapeutic use KW - Oxazolidinones -- therapeutic use KW - Oxazolidinones -- adverse effects KW - Oxacillin -- therapeutic use KW - Dicloxacillin -- adverse effects KW - Oxacillin -- adverse effects KW - Acetamides -- therapeutic use KW - Acetamides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72419615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Randomized+comparison+of+linezolid+%28PNU-100766%29+versus+oxacillin-dicloxacillin+for+treatment+of+complicated+skin+and+soft+tissue+infections.&rft.au=Stevens%2C+D+L%3BSmith%2C+L+G%3BBruss%2C+J+B%3BMcConnell-Martin%2C+M+A%3BDuvall%2C+S+E%3BTodd%2C+W+M%3BHafkin%2C+B&rft.aulast=Stevens&rft.aufirst=D&rft.date=2000-12-01&rft.volume=44&rft.issue=12&rft.spage=3408&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-15 N1 - Date created - 2000-11-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Infect Dis. 1999 Oct;29(4):760-7 [10589883] Antimicrob Agents Chemother. 1997 Nov;41(11):2573-5 [9371372] Antimicrob Agents Chemother. 1987 Feb;31(2):213-8 [2882731] Antimicrob Agents Chemother. 1988 Sep;32(9):1341-6 [3058018] Med Res Rev. 1989 Jan-Mar;9(1):45-89 [2644497] Lancet. 1997 Dec 6;350(9092):1670-3 [9400512] World J Surg. 1998 Feb;22(2):146-51 [9451929] Antimicrob Agents Chemother. 1998 Mar;42(3):721-4 [9517963] Pharmacotherapy. 1998 May-Jun;18(3):456-62 [9620097] Lancet. 1998 Apr 18;351(9110):1212 [9643727] Am J Med. 1998 May 29;104(5A):7S-10S [9684652] Arch Dermatol. 1998 Aug;134(8):1006-9 [9722732] Antimicrob Agents Chemother. 1998 Dec;42(12):3251-5 [9835522] Antimicrob Agents Chemother. 1999 Aug;43(8):2059-62 [10428937] Eur J Clin Microbiol Infect Dis. 1999 Jun;18(6):403-8 [10442417] J Antimicrob Chemother. 1999 Sep;44 Suppl A:19-23 [10511393] Infect Control Hosp Epidemiol. 1992 Oct;13(10):582-6 [1469266] Eur J Clin Microbiol Infect Dis. 1994 Jan;13(1):50-5 [8168564] Clin Infect Dis. 1995 Jun;20 Suppl 2:S154-7 [7548539] N Engl J Med. 1996 Jan 25;334(4):240-5 [8532002] Antimicrob Agents Chemother. 1996 Apr;40(4):839-45 [8849237] Antimicrob Agents Chemother. 1996 Jun;40(6):1508-13 [8726028] Antimicrob Agents Chemother. 1996 Jul;40(7):1745-7 [8807077] Antimicrob Agents Chemother. 1997 Feb;41(2):465-7 [9021209] MMWR Morb Mortal Wkly Rep. 1997 Aug 22;46(33):765-6 [9272582] MMWR Morb Mortal Wkly Rep. 1997 Sep 5;46(35):813-5 [9310213] Clin Infect Dis. 2001 Feb 1;32(3):402-12 [11170948] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epinephrine correction of impaired platelet thromboxane receptor signaling. AN - 72418995; 11078690 AB - This study evaluated the mechanism of epinephrine potentiation of platelet secretion induced by thromboxane A(2) (TXA(2)). Dog platelets that do not secrete in response to TXA(2) alone (TXA(2)-) were compared with dog platelets that do secrete (TXA(2)+) and with human platelets. TXA(2)- platelets had impaired TXA(2) receptor (TP receptor)-G protein coupling, indicated by 1) impaired stimulated GTPase activity, 2) elevated basal guanosine 5'-O-(3-thiotriphosphate) binding, and 3) elevated Galpha(q) palmitate turnover that was corrected by preexposure to epinephrine. Kinetic agonist binding studies revealed biphasic dog and human platelet TP receptor association and dissociation. TXA(2)- and TP receptor-desensitized TXA(2)+ dog and human platelets had altered ligand binding parameters compared with untreated TXA(2)+ or human platelets. These parameters were reversed, along with impaired secretion, by epinephrine. Basal phosphorylation of TXA(2)- platelet TP receptors was elevated 60% and was normalized by epinephrine. Epinephrine potentiates platelet secretion stimulated by TXA(2) by reducing basal TP receptor phosphorylation and facilitating TP receptor-G protein coupling in TXA(2)- platelets and, probably, in normal platelets as well. JF - American journal of physiology. Cell physiology AU - Dunlop, P C AU - Leis, L A AU - Johnson, G J AD - Hematology/Oncology Section, Department of Medicine, Veterans Administration Medical Center and University of Minnesota, Minneapolis, Minnesota 55417, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - C1760 EP - C1771 VL - 279 IS - 6 SN - 0363-6143, 0363-6143 KW - Carbon Radioisotopes KW - 0 KW - Iodine Radioisotopes KW - Mutagens KW - Nitrosamines KW - Palmitates KW - Receptors, Thromboxane KW - Sulfur Radioisotopes KW - Vasoconstrictor Agents KW - Tritium KW - 10028-17-8 KW - Guanosine 5'-O-(3-Thiotriphosphate) KW - 37589-80-3 KW - Thromboxane A2 KW - 57576-52-0 KW - nitrosobis(2-oxopropyl)amine KW - 60599-38-4 KW - 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid KW - 76898-47-0 KW - Inositol 1,4,5-Trisphosphate KW - 85166-31-0 KW - GTP Phosphohydrolases KW - EC 3.6.1.- KW - GTP-Binding Proteins KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid -- pharmacology KW - Animals KW - Humans KW - Nitrosamines -- metabolism KW - Inositol 1,4,5-Trisphosphate -- biosynthesis KW - Amino Acid Sequence KW - Mutagens -- pharmacology KW - Guanosine 5'-O-(3-Thiotriphosphate) -- pharmacology KW - Palmitates -- pharmacology KW - Nitrosamines -- pharmacology KW - Thromboxane A2 -- metabolism KW - Phosphorylation KW - Mutagens -- metabolism KW - Kinetics KW - GTP Phosphohydrolases -- metabolism KW - GTP-Binding Proteins -- metabolism KW - Blood Platelets -- enzymology KW - Molecular Sequence Data KW - Dogs KW - Guanosine 5'-O-(3-Thiotriphosphate) -- metabolism KW - Palmitates -- metabolism KW - Platelet Activation -- physiology KW - Signal Transduction -- physiology KW - Vasoconstrictor Agents -- pharmacology KW - Receptors, Thromboxane -- metabolism KW - Epinephrine -- pharmacology KW - Signal Transduction -- drug effects KW - Receptors, Thromboxane -- chemistry KW - Platelet Activation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72418995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Cell+physiology&rft.atitle=Epinephrine+correction+of+impaired+platelet+thromboxane+receptor+signaling.&rft.au=Dunlop%2C+P+C%3BLeis%2C+L+A%3BJohnson%2C+G+J&rft.aulast=Dunlop&rft.aufirst=P&rft.date=2000-12-01&rft.volume=279&rft.issue=6&rft.spage=C1760&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Cell+physiology&rft.issn=03636143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of cholera toxin and cyclic adenosine monophosphate on fluid-phase endocytosis, distribution, and trafficking of endosomes in rat liver. AN - 70774696; 11093743 AB - In prior studies, we showed that cholera (CTX) and pertussis toxins (PTX) increase rat liver endosome acidification. This study was performed to characterize the effects of these toxins and cyclic adenosine monophosphate (cAMP) on endosome ion transport, fluid-phase endocytosis (FPE), and endosome trafficking in liver. In control liver, more mature populations of endosomes acidified progressively more slowly, but both toxins and cAMP caused retention of an early endosome acidification profile in maturing endosomes. CTX caused a density shift in endosomes, and all agents increased net FPE at time points from 5 to 60 minutes. By confocal microscopy, fluorescent dextrans first appeared in small vesicles at the hepatocyte sinusoidal membrane and trafficked rapidly to the pericanalicular area, near lysosomes and the trans-Golgi network (TGN). Prolonged exposure to these agents caused redistribution of many labeled vesicles to the perinuclear region, colocalized with markers of both early (EEA1 and transferrin receptor) and late (LAMP1) endosomes. We conclude that cAMP is the common agent that disrupted normal maturation and trafficking of endosomes and increased net FPE, in part via decreased diacytosis. JF - Hepatology (Baltimore, Md.) AU - Van Dyke, R W AD - Department of Medicine, University of Michigan Medical School and Veterans' Administration Hospital, Ann Arbor, MI 48109-0682, USA. wynne@umich.edu Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1357 EP - 1369 VL - 32 IS - 6 SN - 0270-9139, 0270-9139 KW - Acids KW - 0 KW - Biomarkers KW - Virulence Factors, Bordetella KW - Bucladesine KW - 63X7MBT2LQ KW - Cholera Toxin KW - 9012-63-9 KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Rats KW - Virulence Factors, Bordetella -- pharmacology KW - Animals KW - Rats, Sprague-Dawley KW - Acids -- metabolism KW - Lysosomes -- metabolism KW - Tissue Distribution -- drug effects KW - Bucladesine -- pharmacology KW - Time Factors KW - Male KW - Acids -- pharmacology KW - Liver -- ultrastructure KW - Endosomes -- physiology KW - Liver -- drug effects KW - Cyclic AMP -- pharmacology KW - Endocytosis -- drug effects KW - Cholera Toxin -- pharmacology KW - Liver -- metabolism KW - Liver -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70774696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Effect+of+cholera+toxin+and+cyclic+adenosine+monophosphate+on+fluid-phase+endocytosis%2C+distribution%2C+and+trafficking+of+endosomes+in+rat+liver.&rft.au=Van+Dyke%2C+R+W&rft.aulast=Van+Dyke&rft.aufirst=R&rft.date=2000-12-01&rft.volume=32&rft.issue=6&rft.spage=1357&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Functional expression of NAD(P)H oxidase p47 in lung microvascular endothelial cells. AN - 72436655; 11095953 AB - Vascular endothelial cell superoxide (O(*)(2)) has an important role in intracellular signaling, in interaction with other reactive species such as nitric oxide, and in vascular dysfunction. Little is known regarding the source and function of O(*)(2) from microvascular endothelial cells from specific tissues. Mouse lung microvascular endothelial cells stimulated with phorbol ester (PMA) or NADPH generated significant O(*)(2), which was inhibited by diphenyleneiodonium (DPI) but not by allopurinol, rotenone, indomethacin, or quinacrine. Optimal O(*)(2) generation required cytosolic as well as particulate cell fractions of cells. In parallel studies, PMA induced increased expression of the p47 component of the NAD(P)H oxidase in the particulate fraction, which was inhibited by staurosporine and calphostin. These data demonstrate that NAD(P)H oxidase is an important source of O(*)(2) generation in lung microvascular endothelial cells. Copyright 2000 Academic Press. JF - Biochemical and biophysical research communications AU - Murphy, H S AU - Yu, C AU - Quddus, J AD - Pathology and Laboratory Medicine, Veterans Administration Medical Center, Ann Arbor, Michigan, 48109, USA. hsmurphy@umich.edu Y1 - 2000/11/30/ PY - 2000 DA - 2000 Nov 30 SP - 584 EP - 589 VL - 278 IS - 3 SN - 0006-291X, 0006-291X KW - Enzyme Inhibitors KW - 0 KW - Onium Compounds KW - Phosphoproteins KW - Rotenone KW - 03L9OT429T KW - Superoxides KW - 11062-77-4 KW - Allopurinol KW - 63CZ7GJN5I KW - diphenyleneiodonium KW - 6HJ411TU98 KW - NADH, NADPH Oxidoreductases KW - EC 1.6.- KW - NADPH Oxidase KW - EC 1.6.3.1 KW - neutrophil cytosolic factor 1 KW - Quinacrine KW - H0C805XYDE KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Onium Compounds -- pharmacology KW - Animals KW - HL-60 Cells KW - Animal Population Groups KW - Humans KW - Mice KW - Rotenone -- pharmacology KW - Quinacrine -- pharmacology KW - Indomethacin -- pharmacology KW - Allopurinol -- pharmacology KW - Superoxides -- metabolism KW - Cells, Cultured KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Microcirculation KW - Signal Transduction KW - Mice, Inbred AKR KW - Endothelium, Vascular -- enzymology KW - Endothelium, Vascular -- drug effects KW - Endothelium, Vascular -- cytology KW - NADH, NADPH Oxidoreductases -- metabolism KW - Pulmonary Circulation KW - Phosphoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72436655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Functional+expression+of+NAD%28P%29H+oxidase+p47+in+lung+microvascular+endothelial+cells.&rft.au=Murphy%2C+H+S%3BYu%2C+C%3BQuddus%2C+J&rft.aulast=Murphy&rft.aufirst=H&rft.date=2000-11-30&rft.volume=278&rft.issue=3&rft.spage=584&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. AN - 72432731; 11087869 AB - There is evidence from both genetic and pharmacologic studies to suggest that the cyclooxygenase-2 (COX-2) enzyme plays a causal role in the development of colorectal cancer. However, little is known about the identity or role of the eicosanoid receptor pathways activated by COX-derived prostaglandins (PG). We previously have reported that COX-2-derived prostacyclin promotes embryo implantation in the mouse uterus via activation of the nuclear hormone receptor peroxisome proliferator-activated receptor (PPAR) delta. In light of the recent finding that PPARdelta is a target of beta-catenin transactivation, it is important to determine whether this signaling pathway is operative during the development of colorectal cancer. Analysis of PPARdelta mRNA in matched normal and tumor samples revealed that expression of PPARdelta, similar to COX-2, is up-regulated in colorectal carcinomas. In situ hybridization studies demonstrate that PPARdelta is expressed in normal colon and localized to the epithelial cells at the very tips of the mucosal glands. In contrast, expression of PPARdelta mRNA in colorectal tumors was more widespread with increased levels in transformed epithelial cells. Analysis of PPARdelta and COX-2 mRNA in serial sections suggested they were colocalized to the same region within a tumor. Finally, transient transfection assays established that endogenously synthesized prostacyclin (PGI(2)) could serve as a ligand for PPARdelta. In addition, the stable PGI(2) analog, carbaprostacyclin, and a synthetic PPARdelta agonist induced transactivation of endogenous PPARdelta in human colon carcinoma cells. We conclude from these observations that PPARdelta, similar to COX-2, is aberrantly expressed in colorectal tumors and that endogenous PPARdelta is transcriptionally responsive to PGI(2). However, the functional consequence of PPARdelta activation in colon carcinogenesis still needs to be determined. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Gupta, R A AU - Tan, J AU - Krause, W F AU - Geraci, M W AU - Willson, T M AU - Dey, S K AU - DuBois, R N AD - Departments of Medicine and Cell Biology, Vanderbilt University Medical Center and Veterans Administration Medical Center, Nashville, TN 37232, USA. Y1 - 2000/11/21/ PY - 2000 DA - 2000 Nov 21 SP - 13275 EP - 13280 VL - 97 IS - 24 SN - 0027-8424, 0027-8424 KW - Isoenzymes KW - 0 KW - Membrane Proteins KW - Nuclear Proteins KW - Receptors, Cytoplasmic and Nuclear KW - Recombinant Fusion Proteins KW - Transcription Factors KW - carboprostacyclin KW - 69552-46-1 KW - Epoprostenol KW - DCR9Z582X0 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Index Medicus KW - Animals KW - Nuclear Proteins -- genetics KW - Rectal Neoplasms KW - Humans KW - Intestinal Mucosa -- enzymology KW - Intestinal Mucosa -- metabolism KW - Transcription, Genetic KW - Mice KW - Isoenzymes -- genetics KW - Recombinant Fusion Proteins -- metabolism KW - In Situ Hybridization KW - Tumor Cells, Cultured KW - Colon KW - Transfection KW - Prostaglandin-Endoperoxide Synthases -- genetics KW - Up-Regulation KW - Adenocarcinoma KW - Nuclear Proteins -- physiology KW - Colonic Neoplasms KW - Signal Transduction KW - Receptors, Cytoplasmic and Nuclear -- physiology KW - Transcription Factors -- physiology KW - Epoprostenol -- pharmacology KW - Colorectal Neoplasms -- pathology KW - Gene Expression Regulation, Neoplastic -- physiology KW - Epoprostenol -- physiology KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Colorectal Neoplasms -- genetics KW - Colorectal Neoplasms -- enzymology KW - Transcription Factors -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Epoprostenol -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72432731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Prostacyclin-mediated+activation+of+peroxisome+proliferator-activated+receptor+delta+in+colorectal+cancer.&rft.au=Gupta%2C+R+A%3BTan%2C+J%3BKrause%2C+W+F%3BGeraci%2C+M+W%3BWillson%2C+T+M%3BDey%2C+S+K%3BDuBois%2C+R+N&rft.aulast=Gupta&rft.aufirst=R&rft.date=2000-11-21&rft.volume=97&rft.issue=24&rft.spage=13275&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-24 N1 - Date created - 2000-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gastroenterology. 1996 Apr;110(4):1259-62 [8613017] J Cell Biochem. 1996 Jun 15;61(4):514-23 [8806074] Genes Dev. 1999 Jun 15;13(12):1561-74 [10385625] Mol Cell. 1999 Jun;3(6):799-804 [10394368] Nature. 1999 Jul 22;400(6742):378-82 [10432118] Cell. 1996 Oct 18;87(2):159-70 [8861899] Cell. 1996 Nov 29;87(5):803-9 [8945508] Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):237-41 [8990192] Ann N Y Acad Sci. 1996 Dec 27;804:176-201 [8993544] Science. 1997 Mar 21;275(5307):1784-7 [9065401] Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3336-40 [9096394] Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4312-7 [9113986] J Clin Invest. 1997 May 1;99(9):2254-9 [9151799] Cell. 1997 Oct 17;91(2):197-208 [9346237] Carcinogenesis. 1997 Nov;18(11):2029-33 [9395198] Nature. 1998 Jan 1;391(6662):79-82 [9422508] Nature. 1998 Jan 1;391(6662):82-6 [9422509] Chem Biol. 1997 Dec;4(12):909-18 [9427656] Diabetes. 1998 Apr;47(4):507-14 [9568680] Cell. 1998 Apr 17;93(2):241-52 [9568716] Gastroenterology. 1998 May;114(5):1095-8 [9606094] Cell. 1998 May 29;93(5):705-16 [9630216] Mol Cell. 1998 Feb;1(3):465-70 [9660931] Nat Med. 1998 Sep;4(9):1046-52 [9734398] FASEB J. 1998 Sep;12(12):1063-73 [9737710] Gastroenterology. 1998 Nov;115(5):1049-55 [9797355] Carcinogenesis. 1998 Dec;19(12):2195-9 [9886578] Carcinogenesis. 1999 Feb;20(2):185-91 [10069452] Nature. 1999 Apr 1;398(6726):422-6 [10201372] J Clin Invest. 1999 Jun;103(11):1509-15 [10359560] Oncogene. 1999 May 6;18(18):2883-91 [10362259] Carcinogenesis. 1999 Nov;20(11):2045-9 [10545404] Recent Prog Horm Res. 1999;54:345-67; discussion 367-8 [10548883] Cell. 1999 Oct 29;99(3):335-45 [10555149] Br J Cancer. 1999 Dec;81(8):1274-9 [10604722] Oncogene. 1999 Dec 20;18(55):7908-16 [10630643] Am J Pathol. 2000 Feb;156(2):545-53 [10666384] J Med Chem. 2000 Feb 24;43(4):527-50 [10691680] N Engl J Med. 2000 Jun 29;342(26):1946-52 [10874062] Cancer Res. 1985 Aug;45(8):3790-5 [4016751] Nature. 1992 Sep 17;359(6392):235-7 [1528264] J Clin Invest. 1994 Feb;93(2):493-8 [8113389] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7355-9 [8041794] Gastroenterology. 1994 Oct;107(4):1183-8 [7926468] Cell. 1994 Dec 30;79(7):1147-56 [8001151] Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):3046-50 [7708772] Cancer Res. 1995 Jun 15;55(12):2556-9 [7780968] Cancer Res. 1995 Sep 1;55(17):3785-9 [7641194] Cell. 1995 Nov 3;83(3):493-501 [8521479] Cell. 1995 Dec 1;83(5):803-12 [8521497] Cell. 1995 Dec 1;83(5):813-9 [8521498] N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Genetic control of the immunologic response to pneumococcal capsular polysaccharides AN - 17735748; 4804583 AB - This brief review will address the limited body of information available on the gentic control of immunologic responses to capsular polysaccharides of Streptococcus pneumoniae (CPS). We hope to show that, although relatively little has been written on this subject, it appears to provide a fertile area for basic, as well as for clinical investigation. Our initial interest in the genetics of human response to CPS grew out of the observation that some perfectly healthy persons fail to make IgG antibody to many or most CPS with which they are vaccinated. This observation, in turn, required the availability of a specific assay to measure such antibody; as a result, we will begin by reviewing briefly the development of such an assay. JF - Vaccine AU - Musher, D M AU - Watson, DA AU - Baughn, R E Y1 - 2000/11/08/ PY - 2000 DA - 2000 Nov 08 SP - 623 EP - 627 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 19 IS - 6 KW - immunology KW - gentic control KW - Streptococcus pneumoniae KW - polysaccharides KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Capsules KW - Reviews KW - Immunoglobulin G KW - Immune response KW - Polysaccharides KW - Pneumonia KW - F 06807:Active immunization KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17735748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Genetic+control+of+the+immunologic+response+to+pneumococcal+capsular+polysaccharides&rft.au=Musher%2C+D+M%3BWatson%2C+DA%3BBaughn%2C+R+E&rft.aulast=Musher&rft.aufirst=D&rft.date=2000-11-08&rft.volume=19&rft.issue=6&rft.spage=623&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Gender differences in the development of substance-related problems: the impact of family history of alcoholism, family history of violence and childhood conduct problems. AN - 72527828; 11188490 AB - This study examined gender differences regarding the relative influence of family history of alcoholism (FHA) and family history of violence (FHV) on reported childhood conduct problems (CCP) and adult problems with alcohol, drugs and violence. The participants were 110 men and 103 women with alcohol-related problems recruited within 30 days of enrolling in treatment for substance abuse or dependence. Participants completed self-report measures of pretreatment violence, FHV, CCP, substance use and consequences, and demographics; a semi-structured interview was used to assess FHA. Structural equation modeling (SEM) analyses revealed gender differences with regard to the influence of FHA and FHV as important factors in the development of childhood and adult behavioral problems. For women, the influence of FHA on subsequent childhood conduct problems and adult problems with alcohol was accounted for by FHV. For men, FHA was not directly associated with CCP or adult problems with alcohol and violence, but was associated with adult drug problems. For both men and women, FHV was associated with CCP, and CCP were associated with adult problems with drugs and violence. Overall, the analyses illustrate the relative importance of FHV as a risk factor in the developmental course leading to problems with drugs and violence among individuals with alcohol-related problems enrolled in treatment for substance abuse or dependence. Further, there was evidence that women may be impacted more than men by family background variables (both FHA and FHV) in terms of the development of adult problems with alcohol, drugs and violence. JF - Journal of studies on alcohol AU - Chermack, S T AU - Stoltenberg, S F AU - Fuller, B E AU - Blow, F C AD - Psychiatry Service, John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan 48201, USA. Stephen.Chermack@med.va.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 845 EP - 852 VL - 61 IS - 6 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Personality Assessment KW - Adolescent KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Child of Impaired Parents -- psychology KW - Child Behavior Disorders -- psychology KW - Gender Identity KW - Personality Development KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Violence -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72527828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Gender+differences+in+the+development+of+substance-related+problems%3A+the+impact+of+family+history+of+alcoholism%2C+family+history+of+violence+and+childhood+conduct+problems.&rft.au=Chermack%2C+S+T%3BStoltenberg%2C+S+F%3BFuller%2C+B+E%3BBlow%2C+F+C&rft.aulast=Chermack&rft.aufirst=S&rft.date=2000-11-01&rft.volume=61&rft.issue=6&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-15 N1 - Date created - 2001-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Elderly Medicare inpatients with substance use disorders: characteristics and predictors of hospital readmissions over a four-year interval. AN - 72527072; 11188495 AB - (1) To describe the characteristics and 4-year readmissions of elderly Medicare inpatients with substance use disorders; (2) to determine whether their readmissions are elevated relative to case controls'; and (3) to examine gender differences in characteristics and predictors of readmissions among elderly inpatients with substance use disorders. Health Care Financing Administration Medicare Provider Analysis and Review data were used to identify elderly patients with substance use disorders and their case controls, and to determine patient characteristics and readmissions over a 4-year interval following hospital discharge. Of elderly inpatients with substance use disorders (N = 22,768), 37% were women, 11% were black, 22% had previous, substance-related hospitalizations, 14% had concomitant psychiatric disorders and 9% had accident-related diagnoses. Among surviving patients with substance use disorders (N = 12,417), 73% were rehospitalized, a higher rate than among case controls (69%). Women with substance use disorders were more likely to have a psychiatric or accident diagnosis at the index episode than were men with substance use disorders. Many women and a disproportionate number of blacks constitute elderly Medicare inpatients with substance use disorders. These patients often have prior substance-related hospitalizations, psychiatric comorbidities, and accidents involving poisoning, adverse drug reactions and falls. They make costly, relatively heavy use of inpatient health services. Elderly women with substance use disorders may benefit from treatment that focuses on their psychiatric disorders and accident risk. Diagnostic information available at discharge can be used to identify patients at higher risk for subsequent rehospitalization and to plan treatment accordingly. JF - Journal of studies on alcohol AU - Brennan, P L AU - Kagay, C R AU - Geppert, J J AU - Moos, R H AD - Center for Health Care Evaluation, VA Palo Alto Health Care System, California 94304, USA. penny.brennan@med.va.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 891 EP - 895 VL - 61 IS - 6 SN - 0096-882X, 0096-882X KW - Index Medicus KW - United States KW - California KW - Mental Disorders -- rehabilitation KW - Risk Factors KW - Mental Disorders -- epidemiology KW - Humans KW - Prognosis KW - Case-Control Studies KW - Aged KW - Male KW - Female KW - Comorbidity KW - Patient Readmission -- statistics & numerical data KW - Alcoholism -- rehabilitation KW - Alcoholism -- epidemiology KW - Medicare KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72527072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Elderly+Medicare+inpatients+with+substance+use+disorders%3A+characteristics+and+predictors+of+hospital+readmissions+over+a+four-year+interval.&rft.au=Brennan%2C+P+L%3BKagay%2C+C+R%3BGeppert%2C+J+J%3BMoos%2C+R+H&rft.aulast=Brennan&rft.aufirst=P&rft.date=2000-11-01&rft.volume=61&rft.issue=6&rft.spage=891&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-15 N1 - Date created - 2001-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Time course inhibition of gastric and platelet COX activity by acetylsalicylic acid in humans. AN - 72374257; 11053009 AB - Aspirin causes peptic ulcers predominately by reducing gastric mucosal cyclooxygenase (COX) activity and prostaglandin synthesis. Because aspirin circulates for only a few hours, we hypothesized that aspirin's inhibitory effect on gastric COX activity must be prolonged. We performed a placebo-controlled experiment in healthy humans to determine the duration of inhibition of aspirin on gastric mucosal COX activity (PGE(2) and PGF(2alpha) synthesis rates). Recovery of gastric COX activity after stopping aspirin was slow and linear. Seventy-two hours after 325-mg aspirin, gastric COX activity was still reduced by 57% (P < 0.001). Duration of inhibition of gastric COX activity was estimated to be 7-8 days after 325-mg aspirin and 5 days after 81-mg aspirin. Recovery of gastric prostaglandin synthesis after 325-mg but not after 81-mg aspirin occurred at slower rates in subjects with Helicobacter pylori-associated gastritis than in those with normal histology. In conclusion, aspirin inhibits gastric COX activity for much longer than predicted from its pharmacokinetic profile, explaining why aspirin at widely spaced intervals is ulcerogenic. JF - American journal of physiology. Gastrointestinal and liver physiology AU - Feldman, M AU - Shewmake, K AU - Cryer, B AD - Medical Service, Dallas Department of Veterans Affairs Medical Center, and Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75216, USA. mark.feldman@med.va.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - G1113 EP - G1120 VL - 279 IS - 5 SN - 0193-1857, 0193-1857 KW - Cyclooxygenase Inhibitors KW - 0 KW - Thromboxane A2 KW - 57576-52-0 KW - Dinoprost KW - B7IN85G1HY KW - Prostaglandin-Endoperoxide Synthases KW - EC 1.14.99.1 KW - Dinoprostone KW - K7Q1JQR04M KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Regression Analysis KW - Helicobacter pylori KW - Dinoprost -- biosynthesis KW - Stomach Ulcer -- microbiology KW - Dinoprostone -- biosynthesis KW - Humans KW - Stomach Ulcer -- metabolism KW - Stomach Ulcer -- chemically induced KW - Adult KW - Gastritis -- metabolism KW - Middle Aged KW - Adolescent KW - Time Factors KW - Thromboxane A2 -- blood KW - Gastritis -- microbiology KW - Female KW - Helicobacter Infections -- metabolism KW - Male KW - Cyclooxygenase Inhibitors -- adverse effects KW - Gastric Mucosa -- microbiology KW - Gastric Mucosa -- enzymology KW - Aspirin -- adverse effects KW - Aspirin -- administration & dosage KW - Prostaglandin-Endoperoxide Synthases -- metabolism KW - Cyclooxygenase Inhibitors -- administration & dosage KW - Blood Platelets -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72374257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Gastrointestinal+and+liver+physiology&rft.atitle=Time+course+inhibition+of+gastric+and+platelet+COX+activity+by+acetylsalicylic+acid+in+humans.&rft.au=Feldman%2C+M%3BShewmake%2C+K%3BCryer%2C+B&rft.aulast=Feldman&rft.aufirst=M&rft.date=2000-11-01&rft.volume=279&rft.issue=5&rft.spage=G1113&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Gastrointestinal+and+liver+physiology&rft.issn=01931857&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transcriptional regulation of the human interleukin 1beta gene by fibronectin: role of protein kinase C and activator protein 1 (AP-1). AN - 72362892; 11052809 AB - Interleukin 1beta (IL-1beta) is a multifunctional polypeptide considered a key cytokine during inflammation. Fibronectin (FN), a matrix glycoprotein highly expressed in injured tissues, can induce expression of IL-1beta in human blood monocytic cells. Herein, we explore the intracellular signals and transcriptional mechanisms responsible for IL-1beta induction by FN using human promonocytic U937 cells transfected with the human IL-1beta promoter connected to a reporter gene. Exposure of transfected U937s to FN resulted in increased expression of the full-length IL-1beta promoter. This effect, mediated via the alpha5beta1 integrin, was associated with activation of mitogen-activated protein kinases (MAPKs) and was abolished by pre-treatment of cells with Calphostin C, a specific inhibitor of protein kinase C (PKC) activation. Deletion analysis and co-transfection studies using consensus activator protein 1 (AP-1) oligonucleotides suggested that an AP-1 site present in the 5' end of the IL-1beta promoter was involved in the FN-induced response. Finally, electrophoretic mobility shift assays showed that FN induced binding of AP-1, but not NF-kappaB. Together, these experiments demonstrate that FN binding to the alpha5beta1 integrin activates MAPK-dependent signal pathways, and results in the transcription of the IL-1beta promoter in U937 cells by activating PKC and inducing AP-1. Copyright 2000 Academic Press. JF - Cytokine AU - Roman, J AU - Ritzenthaler, J D AU - Fenton, M J AU - Roser, S AU - Schuyler, W AD - Pulmonary and Critical Care Division, Department of Medicine, Atlanta Veterans Affairs Medical Center and Emory University School of Medicine, Atlanta, Georgia, USA. roman-rodriguez.jesse@atlanta.va.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 1581 EP - 1596 VL - 12 IS - 11 SN - 1043-4666, 1043-4666 KW - Enzyme Inhibitors KW - 0 KW - Fibronectins KW - Interleukin-1 KW - Lipopolysaccharides KW - NF-kappa B KW - Naphthalenes KW - Oligopeptides KW - RNA, Messenger KW - Receptors, Fibronectin KW - Transcription Factor AP-1 KW - arginyl-glycyl-aspartic acid KW - 78VO7F77PN KW - Chloramphenicol O-Acetyltransferase KW - EC 2.3.1.28 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Mitogen-Activated Protein Kinase 1 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 3 KW - Mitogen-Activated Protein Kinases KW - calphostin C KW - I271P23G24 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Naphthalenes -- pharmacology KW - Blotting, Northern KW - Electroporation KW - Lipopolysaccharides -- pharmacology KW - Humans KW - Receptors, Fibronectin -- metabolism KW - Promoter Regions, Genetic KW - Genes, Reporter KW - Signal Transduction KW - Enzyme Activation KW - Dose-Response Relationship, Drug KW - Mitogen-Activated Protein Kinases -- metabolism KW - Chloramphenicol O-Acetyltransferase -- metabolism KW - Precipitin Tests KW - Reverse Transcriptase Polymerase Chain Reaction KW - Gene Deletion KW - Blotting, Western KW - MAP Kinase Signaling System KW - RNA, Messenger -- metabolism KW - Transfection KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Oligopeptides -- pharmacology KW - U937 Cells KW - Cell Adhesion KW - NF-kappa B -- metabolism KW - Protein Kinase C -- antagonists & inhibitors KW - Interleukin-1 -- metabolism KW - Fibronectins -- metabolism KW - Transcription, Genetic KW - Interleukin-1 -- genetics KW - Gene Expression Regulation KW - Protein Kinase C -- physiology KW - Transcription Factor AP-1 -- physiology KW - Fibronectins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72362892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine&rft.atitle=Transcriptional+regulation+of+the+human+interleukin+1beta+gene+by+fibronectin%3A+role+of+protein+kinase+C+and+activator+protein+1+%28AP-1%29.&rft.au=Roman%2C+J%3BRitzenthaler%2C+J+D%3BFenton%2C+M+J%3BRoser%2C+S%3BSchuyler%2C+W&rft.aulast=Roman&rft.aufirst=J&rft.date=2000-11-01&rft.volume=12&rft.issue=11&rft.spage=1581&rft.isbn=&rft.btitle=&rft.title=Cytokine&rft.issn=10434666&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2000-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of arsenite on the induction of CYP1A4 and CYP1A5 in cultured chick embryo hepatocytes. AN - 72355552; 11042089 AB - We had reported previously that 2.5-5 microM sodium arsenite decreased the phenobarbital-mediated induction of CYP2H activity and protein but not CYP2H1 mRNA in chick-embryo hepatocyte cultures. Induction of a CYP1A activity and protein by 3-methylcholanthrene was also decreased by low arsenite concentrations; however, CYP1A mRNAs were not measured in those studies. We report here that low concentrations of arsenite decreased induction of activities and mRNAs of two chicken cytochromes P450, CYP1A (1A4 and 1A5), by 3-methylcholanthrene in chick-embryo hepatocyte cultures. Arsenite treatment did not affect the turnover of either mRNA, nor did it decrease the superinduction of each mRNA caused by treatment with cycloheximide in addition to 3-methylcholanthrene. Glutathione depletion enhanced the effect of arsenite to decrease induction of CYP1A4. These results indicate the induction of CYP1A4 and 1A5 is inhibited by sodium arsenite at the level of transcription, suggesting that the Ah receptor complex may be involved. Copyright 2000 Academic Press. JF - Toxicology and applied pharmacology AU - Jacobs, J M AU - Nichols, C AU - Marek, D AU - Gorman, N AU - Walton, H S AU - Sinclair, P R AU - Sinclair, J F AD - Veterans Administration Medical Center, White River Junction, VT 05009-0001, USA. Y1 - 2000/11/01/ PY - 2000 DA - 2000 Nov 01 SP - 177 EP - 182 VL - 168 IS - 3 SN - 0041-008X, 0041-008X KW - Arsenites KW - 0 KW - Avian Proteins KW - Indicators and Reagents KW - Protein Synthesis Inhibitors KW - RNA, Messenger KW - Uroporphyrinogens KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Cycloheximide KW - 98600C0908 KW - Oxidoreductases KW - EC 1.- KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1A4 protein, Gallus gallus KW - cytochrome P-450 CYP1A5 KW - Glutathione KW - GAN16C9B8O KW - arsenite KW - N5509X556J KW - Index Medicus KW - Oxidation-Reduction KW - Animals KW - Protein Synthesis Inhibitors -- pharmacology KW - Enzyme Induction -- drug effects KW - Cells, Cultured KW - Cycloheximide -- pharmacology KW - Chick Embryo KW - Microsomes, Liver -- enzymology KW - Microsomes, Liver -- drug effects KW - Glutathione -- physiology KW - Uroporphyrinogens -- biosynthesis KW - RNA, Messenger -- biosynthesis KW - Hepatocytes -- drug effects KW - Oxidoreductases -- metabolism KW - Arsenites -- toxicity KW - Cytochrome P-450 Enzyme System -- metabolism KW - Cytochrome P-450 Enzyme System -- biosynthesis KW - Hepatocytes -- enzymology KW - Oxidoreductases -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72355552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Effect+of+arsenite+on+the+induction+of+CYP1A4+and+CYP1A5+in+cultured+chick+embryo+hepatocytes.&rft.au=Jacobs%2C+J+M%3BNichols%2C+C%3BMarek%2C+D%3BGorman%2C+N%3BWalton%2C+H+S%3BSinclair%2C+P+R%3BSinclair%2C+J+F&rft.aulast=Jacobs&rft.aufirst=J&rft.date=2000-11-01&rft.volume=168&rft.issue=3&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-04 N1 - Date created - 2000-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nutritional and health benefits of beer. AN - 70783222; 11093684 AB - Physicians should be aware of the growing evidence supporting the nutritional and health benefits of moderate consumption of alcohol as part of a healthy lifestyle. The recently approved voluntary label on wine ("the proud people who made this wine encourage you to consult your family doctor about the health effects of wine consumption") implies that physicians should promote wine as the preferred source of dietary alcohol. However, studies evaluating the relative benefits of wine versus beer versus spirits suggest that moderate consumption of any alcoholic beverage is associated with lower rates of cardiovascular disease. From a nutritional standpoint, beer contains more protein and B vitamins than wine. The antioxidant content of beer is equivalent to that of wine, but the specific antioxidants are different because the barley and hops used in the production of beer contain flavonoids different from those in the grapes used in the production of wine. The benefits of moderate alcohol consumption have not been generally endorsed by physicians for fear that heavy consumers may consider any message as a permissive license to drink in excess. Discussions with patients regarding alcohol consumption should be made in the context of a general medical examination. There is no evidence to support endorsement of one type of alcoholic beverage over another. The physician should define moderate drinking (1 drink per day for women and 2 drinks per day for men) for the patient and should review consumption patterns associated with high risk. JF - The American journal of the medical sciences AU - Denke, M A AD - Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Veterans Health Administration North Texas Health Care System, USA. mdenke@ednet.swmed.edu Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 320 EP - 326 VL - 320 IS - 5 SN - 0002-9629, 0002-9629 KW - Abridged Index Medicus KW - Index Medicus KW - Self Disclosure KW - Reproducibility of Results KW - Alcoholism -- diagnosis KW - Risk Factors KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Health Policy KW - Physician-Patient Relations KW - Alcoholism -- psychology KW - Male KW - Female KW - Beer -- analysis KW - Coronary Disease -- mortality KW - Nutritive Value KW - Coronary Disease -- diet therapy KW - Alcohol Drinking -- psychology KW - Alcohol Drinking -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70783222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Nutritional+and+health+benefits+of+beer.&rft.au=Denke%2C+M+A&rft.aulast=Denke&rft.aufirst=M&rft.date=2000-11-01&rft.volume=320&rft.issue=5&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-11 N1 - Date created - 2000-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improving treatment adherence in drug abusers who are HIV-positive. AN - 70607626; 16398004 AB - This article discusses the complex dual diagnosis of HIV/AIDS (Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome) and substance abuse, which affects a growing number of individuals worldwide. A brief review of HIV/AIDS is provided and the connection between HIV/AIDS and substance abuse is described. Substance abuse complicates both HIV/AIDS and its management because of the effects that illicit drugs have on various body systems and because of the behavioral disturbances that accompany substance use. For a variety of reasons adherence to treatment is poor in this population and several factors that negatively impact adherence are outlined. Treatment of drug abusers who are HIV-positive requires more flexibility than treating drug abuse and HIV separately. Because medication regimens can be complicated and demanding and nonadherence to treatment can cause mutation of the virus resulting in drug-resistant strains, it is essential to get the patient committed to treatment The goals of treatment are abstinence from illicit drugs, adherence to a treatment regimen, suppression of viral load, improved CD4 count, and improved quality of life. The role of the case manager is critical to improving treatment adherence. Essential attributes include knowledge of disease processes, critical thinking, and the ability to navigate the healthcare system. Case management interventions to improve treatment adherence should be directed at the patient, the regimen, the client-patient relationship, and the healthcare system. Because HIV/AIDS is now classified as a chronic disease and is no longer viewed as a death sentence, people who are HIV-positive have hope for longevity and a cure. It is this hope for a longer life and possible cure that can be used to motivate substance abusers who are HIV-infected to improve their treatment adherence and quality of life. JF - Lippincott's case management : managing the process of patient care AU - Malone, S B AU - Osborne, J J AD - Drug Dependence Treatment Program, Veterans Affairs Maryland Health Care System, 10 North Greene Street, Baltimore, MD 21201, USA. Sandra.Malone@med.va.gov PY - 2000 SP - 236 EP - 45; quiz 245-7 VL - 5 IS - 6 SN - 1529-7764, 1529-7764 KW - Nursing KW - Humans KW - Professional-Patient Relations KW - HIV Infections -- complications KW - Patient Compliance -- psychology KW - HIV Infections -- drug therapy KW - Antiretroviral Therapy, Highly Active KW - Substance-Related Disorders -- complications KW - Case Management KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70607626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lippincott%27s+case+management+%3A+managing+the+process+of+patient+care&rft.atitle=Improving+treatment+adherence+in+drug+abusers+who+are+HIV-positive.&rft.au=Malone%2C+S+B%3BOsborne%2C+J+J&rft.aulast=Malone&rft.aufirst=S&rft.date=2000-11-01&rft.volume=5&rft.issue=6&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Lippincott%27s+case+management+%3A+managing+the+process+of+patient+care&rft.issn=15297764&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-08 N1 - Date created - 2006-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sex Differences in Self-Reported and Physiological Response to Oral Cocaine and Placebo in Humans AN - 60396797; 200110717 AB - Self-report & physiological data from 27 male & 8 female cocaine-abusing volunteers exposed to cocaine (80 mg/70 kg po) & placebo were examined for sex differences in their responses. Females reported significantly greater baseline ratings on the Pentobarbital-Chlorpromazine-Alcohol Group (PCAG) (sedation) & Lysergic Acid Diethylamide (LSD) (dysphoria) subclass of the Addiction Research Center Inventory-Short Form (ARCI) relative to males. In addition, females reported significantly greater ratings on the Visual Analogs Scales (VAS) Bad Drug Effects & Anxious/Nervous scales relative to males, regardless of drug. Cocaine produced greater increase in systolic blood pressure in males following cocaine, whereas females showed greater increases in following placebos. These results suggest that a placebo control is necessary to determine sex differences in response to an active drug. 1 Table, 3 Figures, 26 References. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Singha, Amrita K AU - McCance-Katz, Elinore F AU - Petrakis, Ismene AU - Kosten, Thomas R AU - Oliveto, Alison AD - c/o Oliveto -- Dept Psychiatry, VA Connecticut Healthcare System, West Haven Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 643 EP - 657 VL - 26 IS - 4 SN - 0095-2990, 0095-2990 KW - Placebo Effect KW - Responses KW - Sex Differences KW - Cocaine KW - Connecticut KW - article KW - 2983: feminist/gender studies; sociology of gender & gender relations KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60396797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Sex+Differences+in+Self-Reported+and+Physiological+Response+to+Oral+Cocaine+and+Placebo+in+Humans&rft.au=Singha%2C+Amrita+K%3BMcCance-Katz%2C+Elinore+F%3BPetrakis%2C+Ismene%3BKosten%2C+Thomas+R%3BOliveto%2C+Alison&rft.aulast=Singha&rft.aufirst=Amrita&rft.date=2000-11-01&rft.volume=26&rft.issue=4&rft.spage=643&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Cocaine; Sex Differences; Responses; Placebo Effect; Connecticut ER - TY - JOUR T1 - Interaction of tetanus toxin derived hybrid proteins with neuronal cells AN - 17812202; 4856997 AB - The non-toxic ganglioside binding domain of tetanus toxin (Hc fragment C or TTC) has been studied as a vector for delivering therapeutic proteins to neurons. There is little information on the cellular processing of proteins delivered by linkage to TTC. We have evaluated the cellular handling of a multi-domain hybrid protein containing TTC and both the human enzyme superoxide dismutase and the maltose binding protein from E. coli. Binding, internalization, and cleavage of this protein during prolonged incubation with fetal cortical neurons or cells of the N18-RE-105 line was evaluated by immunoblot analysis, ELISA, and immunocytochemistry. Hybrid proteins were bound and internalized in a manner very similar to TTC. Internalized proteins showed long-term stability within cells, and were degraded into predictable large protein fragments in both cell types. Fragments that were cleaved away from the TTC domain were released into extracellular fluid after internalization. Proteins coupled to TTC share its long-term stability after cellular internalization. After internalization, dissociation of proteins linked to TTC facilitates their release from the cell, but not into other cellular compartments such as the cytosol. TTC linked proteins are probably enclosed within a stable endosomal compartment throughout their cellular lifetime. JF - Journal of Natural Toxins AU - Figueiredo, D M AU - Matthews, C C AU - Parks, DA AU - Fairweather, N F AU - Dougan, G AU - Wilt, S G AU - Fishman, P S AD - Neurology Service, Baltimore Veterans Administration Medical Center, Baltimore, MD 21201, USA, pfishman@umaryland.edu Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 363 EP - 379 VL - 9 IS - 4 SN - 1058-8108, 1058-8108 KW - maltose-binding protein KW - CSA Neurosciences Abstracts; Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Gangliosides KW - Tetanus KW - Toxins KW - Superoxide dismutase KW - Neurons KW - Escherichia coli KW - X 24171:Microbial KW - N3 11101:General KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17812202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Natural+Toxins&rft.atitle=Interaction+of+tetanus+toxin+derived+hybrid+proteins+with+neuronal+cells&rft.au=Figueiredo%2C+D+M%3BMatthews%2C+C+C%3BParks%2C+DA%3BFairweather%2C+N+F%3BDougan%2C+G%3BWilt%2C+S+G%3BFishman%2C+P+S&rft.aulast=Figueiredo&rft.aufirst=D&rft.date=2000-11-01&rft.volume=9&rft.issue=4&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Journal+of+Natural+Toxins&rft.issn=10588108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Toxins; Tetanus; Neurons; Gangliosides; Superoxide dismutase ER - TY - JOUR T1 - Evaluation of rifalazil in a combination treatment regimen as an alternative to isoniazid-rifampin therapy in a mouse tuberculosis model AN - 17642122; 4795101 AB - The newer rifamycin, rifalazil (RLZ) (previously known as KRM-1648), has been shown in prior experiments to be a highly potent drug against Mycobacterium tuberculosis. In this report, we studied the efficacy of RLZ in combination with pyrazinamide (PZA) and ethambutol (EMB) in a long-term in vivo experiment and compared their activity with the isoniazid (INH)-rifampin (RIF) combination which is presently used in the clinic. Combinations of RLZ with PZA alone or with both PZA and EMB were both found to have sterilizing activities comparable to that of the INH-RIF combination but significantly better activity with respect to relapse of infection. These results suggest that RLZ, or other agents with similar activity, could be combined with available agents to act as a potential alternative drug regimen to the currently used INH-RIF combination. JF - Antimicrobial Agents & Chemotherapy AU - Lenaerts, A M AU - Chase, ShE AU - Cynamon, M H AD - VAMC, 800 Irving Ave., Syracuse, NY 13210, USA, Michael.Cynamon@med.va.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 3167 EP - 3168 VL - 44 IS - 11 SN - 0066-4804, 0066-4804 KW - Pyrazinamide KW - Microbiology Abstracts B: Bacteriology KW - Rifampin KW - Animal models KW - Tuberculosis KW - Antibacterial agents KW - ethambutol KW - Rifamycins KW - Mycobacterium tuberculosis KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17642122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Evaluation+of+rifalazil+in+a+combination+treatment+regimen+as+an+alternative+to+isoniazid-rifampin+therapy+in+a+mouse+tuberculosis+model&rft.au=Lenaerts%2C+A+M%3BChase%2C+ShE%3BCynamon%2C+M+H&rft.aulast=Lenaerts&rft.aufirst=A&rft.date=2000-11-01&rft.volume=44&rft.issue=11&rft.spage=3167&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.44.11.3167-3168.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Tuberculosis; Animal models; Antibacterial agents; Rifamycins; ethambutol; Rifampin DO - http://dx.doi.org/10.1128/AAC.44.11.3167-3168.2000 ER - TY - JOUR T1 - Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice. AN - 72344399; 11032766 AB - CYP2E1 has been reported to have an essential role in alcohol-mediated increases in hepatic steatosis and acetaminophen hepatotoxicity. We found that pretreatment of Cyp2e1(-/-) mice with ethanol plus isopentanol, the predominant alcohols in alcoholic beverages, for 7 days resulted in micro- and macrovesicular steatosis in the livers of all mice, as well as a dramatic increase in acetaminophen hepatotoxicity. In Cyp2e1(-/-) mice administered up to 600 mg acetaminophen/kg alone and euthanized 7 h later, there was no increase in serum levels of ALT. In Cyp2e1(-/-) mice pretreated with ethanol and isopentanol, subsequent exposure to 400 or 600 mg acetaminophen/kg resulted in centrilobular necrosis in all mice with maximal elevation in serum levels of ALT. Acetaminophen-mediated liver damage was similar in males and females. Hepatic microsomal levels of APAP activation in untreated females were similar to those in males treated with the alcohols. However, the females, like the males, required pretreatment with the alcohols in order to increase APAP hepatotoxicity. These findings suggest that, in the Cyp2e1(-/-) mice, the alcohol-mediated increase in acetaminophen hepatotoxicity involves the contribution of other factors, in addition to induction of CYP(s) that activate acetaminophen. Alternatively, CYP-mediated activation of acetaminophen measured in vitro may not reflect the actual activity in vivo. Our findings that a 7-day treatment with ethanol and isopentanol causes extensive hepatic steatosis and increases acetaminophen hepatotoxicity in Cyp2e(-/-) mice indicate that CYP2E1 is not essential for either response. Copyright 2000 Academic Press. JF - Toxicology and applied pharmacology AU - Sinclair, J F AU - Szakacs, J G AU - Wood, S G AU - Walton, H S AU - Bement, J L AU - Gonzalez, F J AU - Jeffery, E H AU - Wrighton, S A AU - Bement, W J AU - Sinclair, P R AD - Veterans Administration Medical Center, White River Junction, Vermont, 05009, USA. JSINC@dartmouth.edu Y1 - 2000/10/15/ PY - 2000 DA - 2000 Oct 15 SP - 114 EP - 122 VL - 168 IS - 2 SN - 0041-008X, 0041-008X KW - Analgesics, Non-Narcotic KW - 0 KW - Benzoquinones KW - Imines KW - Pentanols KW - Acetaminophen KW - 362O9ITL9D KW - Ethanol KW - 3K9958V90M KW - isopentyl alcohol KW - DEM9NIT1J4 KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - N-acetyl-4-benzoquinoneimine KW - G6S9BN13TI KW - Index Medicus KW - Animals KW - Liver -- pathology KW - Liver -- enzymology KW - Sex Factors KW - Liver -- drug effects KW - Benzoquinones -- metabolism KW - Mice, Inbred C57BL KW - Mice KW - Liver Diseases -- enzymology KW - Drug Synergism KW - Imines -- metabolism KW - Male KW - Female KW - Biotransformation -- drug effects KW - Fatty Liver, Alcoholic -- enzymology KW - Analgesics, Non-Narcotic -- pharmacokinetics KW - Acetaminophen -- pharmacokinetics KW - Fatty Liver, Alcoholic -- etiology KW - Chemical and Drug Induced Liver Injury KW - Analgesics, Non-Narcotic -- toxicity KW - Ethanol -- toxicity KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Pentanols -- toxicity KW - Cytochrome P-450 CYP2E1 -- genetics KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72344399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Short-term+treatment+with+alcohols+causes+hepatic+steatosis+and+enhances+acetaminophen+hepatotoxicity+in+Cyp2e1%28-%2F-%29+mice.&rft.au=Sinclair%2C+J+F%3BSzakacs%2C+J+G%3BWood%2C+S+G%3BWalton%2C+H+S%3BBement%2C+J+L%3BGonzalez%2C+F+J%3BJeffery%2C+E+H%3BWrighton%2C+S+A%3BBement%2C+W+J%3BSinclair%2C+P+R&rft.aulast=Sinclair&rft.aufirst=J&rft.date=2000-10-15&rft.volume=168&rft.issue=2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-16 N1 - Date created - 2000-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulation of the bovine kidney microsomal chloride channel p64 by p59fyn, a Src family tyrosine kinase. AN - 72345652; 10930415 AB - p64 is a chloride channel of intracellular membranes which is present in regulated secretory vesicles. Mechanisms by which the p64 channel could be regulated are largely unknown. p59(fyn) is a non-receptor tyrosine kinase of the Src family that has been implicated in a variety of intracellular signaling events. The N-terminal portion of p64 has several potential binding sites for Src family SH2 domains. In this paper, we demonstrate that p64 becomes tyrosine phosphorylated when co-expressed with p59(fyn) in HeLa cells. We show that co-expression of p64 with p59(fyn) renders p64 a ligand for the SH2 domain of p59(fyn) and this SH2 binding is eliminated by treating p64 with alkaline phosphatase. Using site-directed mutagenesis, we find that tyrosine 33 in the p64 sequence is necessary for SH2 binding. We also characterized p64-p59(fyn) interactions using native material from bovine kidney. We found that a small fraction of native kidney p64 can bind Fyn SH2 in vitro. Immunoprecipitation of p64 from solubilized kidney membranes yields a kinase activity with the same mobility by SDS-polyacrylamide gel electrophoresis as authentic bovine p59(fyn). Finally, we demonstrate that co-expression of p64 and p59(fyn) in HeLa cells results in enhanced p64-associated chloride channel activity. JF - The Journal of biological chemistry AU - Edwards, J C AU - Kapadia, S AD - Renal Division, Department of Medicine, St. Louis University and the St. Louis Veterans Affairs Medical Center, St. Louis, Missouri 63106, USA. John.Edwards3@med.va.gov Y1 - 2000/10/13/ PY - 2000 DA - 2000 Oct 13 SP - 31826 EP - 31832 VL - 275 IS - 41 SN - 0021-9258, 0021-9258 KW - CLCNKA protein, human KW - 0 KW - Chloride Channels KW - Proto-Oncogene Proteins KW - Recombinant Fusion Proteins KW - Phosphotyrosine KW - 21820-51-9 KW - FYN protein, human KW - EC 2.7.10.2 KW - Proto-Oncogene Proteins c-fyn KW - src-Family Kinases KW - Index Medicus KW - Animals KW - Kidney -- metabolism KW - HeLa Cells KW - Humans KW - Gene Expression KW - Phosphotyrosine -- metabolism KW - Precipitin Tests KW - Protein Binding KW - src Homology Domains KW - Mutagenesis KW - Recombinant Fusion Proteins -- metabolism KW - Cattle KW - Phosphorylation KW - Transfection KW - src-Family Kinases -- genetics KW - Microsomes -- metabolism KW - src-Family Kinases -- metabolism KW - Proto-Oncogene Proteins -- metabolism KW - Chloride Channels -- metabolism KW - Proto-Oncogene Proteins -- genetics KW - Chloride Channels -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72345652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Regulation+of+the+bovine+kidney+microsomal+chloride+channel+p64+by+p59fyn%2C+a+Src+family+tyrosine+kinase.&rft.au=Edwards%2C+J+C%3BKapadia%2C+S&rft.aulast=Edwards&rft.aufirst=J&rft.date=2000-10-13&rft.volume=275&rft.issue=41&rft.spage=31826&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-13 N1 - Date created - 2000-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Approach to patients with refractory constipation. AN - 72540785; 10998666 AB - Constipation is a very frequent problem, particularly in elderly patients. Constipation is a common reason for patients to seek medical advice, and it accounts for a large number of different prescription and over-the-counter medications. In many cases, no definite cause can be found. Most patients respond to conservative therapy with increased fiber and fluid intake alone. Patients with constipation that is more difficult to control or with alarm symptoms (eg, blood in stool, sudden onset, weight loss, or decreasing stool caliber) warrant further investigation. A variety of medical, behavioral, and surgical therapies can be employed to help these more refractory patients. JF - Current gastroenterology reports AU - Wofford, S A AU - Verne, G N AD - Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Department of Medicine, Veterans Administration Medical Center, Research Service (151), 1601 SW Archer Road, Gainesville, FL 32608, USA. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 389 EP - 394 VL - 2 IS - 5 SN - 1522-8037, 1522-8037 KW - Cathartics KW - 0 KW - Narcotics KW - Index Medicus KW - Gastrointestinal Motility KW - Biofeedback, Psychology KW - Cathartics -- therapeutic use KW - Humans KW - Narcotics -- adverse effects KW - Dietary Fiber -- therapeutic use KW - Constipation -- diagnosis KW - Constipation -- etiology KW - Constipation -- therapy KW - Constipation -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72540785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+gastroenterology+reports&rft.atitle=Approach+to+patients+with+refractory+constipation.&rft.au=Wofford%2C+S+A%3BVerne%2C+G+N&rft.aulast=Wofford&rft.aufirst=S&rft.date=2000-10-01&rft.volume=2&rft.issue=5&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Current+gastroenterology+reports&rft.issn=15228037&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-17 N1 - Date created - 2001-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pure class III antiarrhythmic drugs: focus on dofetilide. AN - 72470730; 11150393 JF - Journal of cardiovascular pharmacology and therapeutics AU - Doshi, S K AU - Singh, B N AD - Veterans Administration Greater Los Angeles Health Care System, CA 90073, USA. skdoshi@ucla.edu Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 237 EP - 247 VL - 5 IS - 4 SN - 1074-2484, 1074-2484 KW - Anti-Arrhythmia Agents KW - 0 KW - Phenethylamines KW - Sulfonamides KW - dofetilide KW - R4Z9X1N2ND KW - Index Medicus KW - Animals KW - Humans KW - Heart Failure -- complications KW - Dogs KW - Disease Models, Animal KW - Electrophysiology KW - Sulfonamides -- pharmacokinetics KW - Phenethylamines -- pharmacokinetics KW - Phenethylamines -- adverse effects KW - Sulfonamides -- adverse effects KW - Sulfonamides -- pharmacology KW - Arrhythmias, Cardiac -- drug therapy KW - Anti-Arrhythmia Agents -- pharmacokinetics KW - Phenethylamines -- pharmacology KW - Anti-Arrhythmia Agents -- adverse effects KW - Anti-Arrhythmia Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72470730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.atitle=Pure+class+III+antiarrhythmic+drugs%3A+focus+on+dofetilide.&rft.au=Doshi%2C+S+K%3BSingh%2C+B+N&rft.aulast=Doshi&rft.aufirst=S&rft.date=2000-10-01&rft.volume=5&rft.issue=4&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.issn=10742484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-01 N1 - Date created - 2001-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antipyretic Therapy's future. AN - 72467619; 11113030 AB - There is little doubt that clinicians will continue to seek new and, one hopes, more intelligent ways to suppress fever. In the process, new agents will be developed, new uses will be identified for existing antipyretic agents, new measures will be designed to maximize the benefits of antipyretic therapy while minimizing its adverse effects, and a concerted effort will be made to define more clearly and to promote appropriate indications for such therapy. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Mackowiak, P A AD - Medical Care Clinical Center, VA Maryland Health Care System and the Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Philip.Mackowiak@med.va.gov Y1 - 2000/10// PY - 2000 DA - October 2000 SP - S242 EP - S243 VL - 31 Suppl 5 SN - 1058-4838, 1058-4838 KW - Analgesics, Non-Narcotic KW - 0 KW - Index Medicus KW - Humans KW - Forecasting KW - Drug Utilization KW - Drug Design KW - Risk Assessment KW - Analgesics, Non-Narcotic -- adverse effects KW - Analgesics, Non-Narcotic -- therapeutic use KW - Fever -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72467619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Antipyretic+Therapy%27s+future.&rft.au=Mackowiak%2C+P+A&rft.aulast=Mackowiak&rft.aufirst=P&rft.date=2000-10-01&rft.volume=31+Suppl+5&rft.issue=&rft.spage=S242&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diagnostic implications and clinical consequences of antipyretic therapy. AN - 72466330; 11113028 AB - It has been suggested that the response to antipyretic therapy might differentiate between fevers due to serious illness and fevers caused by less severe disorders; that neoplastic fevers are more responsive to nonsteroidal anti-inflammatory drugs than are infectious fevers; that the metabolic costs of fever can exceeds its clinical benefits; that antipyretic therapy can prevent or reverse febrile seizures in children and fever-associated mental dysfunction in frail elderly patients. This article examines the data on which these assertions are based. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Mackowiak, P A AD - Medical Care Clinical Center, VA Maryland Health Care System and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Philip.Mackowiak@med.va.gov Y1 - 2000/10// PY - 2000 DA - October 2000 SP - S230 EP - S233 VL - 31 Suppl 5 SN - 1058-4838, 1058-4838 KW - Analgesics, Non-Narcotic KW - 0 KW - Index Medicus KW - Neoplasms -- complications KW - Seizures, Febrile -- prevention & control KW - Humans KW - Seizures, Febrile -- chemically induced KW - Child KW - Bacterial Infections -- complications KW - Adolescent KW - Child, Preschool KW - Fever -- etiology KW - Analgesics, Non-Narcotic -- adverse effects KW - Analgesics, Non-Narcotic -- therapeutic use KW - Fever -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72466330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Diagnostic+implications+and+clinical+consequences+of+antipyretic+therapy.&rft.au=Mackowiak%2C+P+A&rft.aulast=Mackowiak&rft.aufirst=P&rft.date=2000-10-01&rft.volume=31+Suppl+5&rft.issue=&rft.spage=S230&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of LAAM and methadone utilization in an opiate agonist treatment program. AN - 72402115; 11064490 AB - The development and approval of levo-alpha-acetylmethadol (LAAM) as a pharmacotherapeutic agent in opioid agonist therapy provided an alternative to methadone. Clinicians recognized the potential benefits that LAAM, a synthetic mu agonist with pharmacological properties which differ from those of methadone,could have in the treatment management of addicts in opioid agonist therapy. We report our experience utilizing LAAM from 1995 to 1999 at the Hines VA opioid agonist therapy clinic. The addition of LAAM to the clinic's treatment armamentarium has resulted in management options that have improved the areas of patient recruitment, patient retention, patient traffic, take-home medication, detoxification, and treatment outcomes. JF - The Mount Sinai journal of medicine, New York AU - Valdivia, J F AU - Khattak, S AD - Drug Dependency Treatment Program, Building 228, Mail Code 116c, Hines Veterans Administration Hospital, Hines, IL 60141, USA. PY - 2000 SP - 398 EP - 403 VL - 67 IS - 5-6 SN - 0027-2507, 0027-2507 KW - Analgesics, Opioid KW - 0 KW - Methadyl Acetate KW - L59OC40KWJ KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Therapeutic Equivalency KW - Drug Tolerance KW - Methadone -- therapeutic use KW - Humans KW - Treatment Outcome KW - Patient Selection KW - Methadone -- pharmacology KW - Methadyl Acetate -- pharmacology KW - Analgesics, Opioid -- pharmacology KW - Analgesics, Opioid -- therapeutic use KW - Methadyl Acetate -- therapeutic use KW - Opioid-Related Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72402115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Mount+Sinai+journal+of+medicine%2C+New+York&rft.atitle=Effects+of+LAAM+and+methadone+utilization+in+an+opiate+agonist+treatment+program.&rft.au=Valdivia%2C+J+F%3BKhattak%2C+S&rft.aulast=Valdivia&rft.aufirst=J&rft.date=2000-10-01&rft.volume=67&rft.issue=5-6&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=The+Mount+Sinai+journal+of+medicine%2C+New+York&rft.issn=00272507&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-22 N1 - Date created - 2000-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Depression of retinal glutamate transporter function leads to elevated intravitreal glutamate levels and ganglion cell death. AN - 72296150; 11006260 AB - Elevated levels of extracellular glutamate have been implicated in the pathophysiology of neuronal loss in both central nervous system and ophthalmic disorders, including glaucoma. This increase in glutamate may result from a failure of glutamate transporters (molecules that ordinarily regulate extracellular glutamate; E:xcitatory A:mino A:cid T:ransporter; EAAT). Elevated glutamate levels can also lead to alterations in glutamate receptor expression. It was hypothesized that selective blockade of glutamate transporters would be toxic to retinal ganglion cells. Glutamate transporters were blocked either pharmacologically or with subtype-specific antisense oligonucleotides against EAAT1. Glutamate levels, transporter levels and ganglion cell survival were assayed. Pharmacological inhibition of glutamate transporters with either an EAAT2 specific inhibitor or a nonspecific inhibitor of all the subtypes of transporters was toxic to ganglion cells. Treatment with oligonucleotides against the glutamate transporter EAAT1 decreased the levels of expression of the transporter, increased vitreal glutamate, and was toxic to ganglion cells. These results demonstrate that normal function of EAAT1 and EAAT2 is necessary for retinal ganglion cell survival and plays an important role in retinal excitotoxicity. Manipulation of retinal glutamate transporter expression may become a useful tool in understanding retinal neuronal loss. JF - Investigative ophthalmology & visual science AU - Vorwerk, C K AU - Naskar, R AU - Schuettauf, F AU - Quinto, K AU - Zurakowski, D AU - Gochenauer, G AU - Robinson, M B AU - Mackler, S A AU - Dreyer, E B AD - Scheie Eye Institute, Philadelphia Veterans Administration, the University of Pennsylvania, Philadelphia 19104, USA. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 3615 EP - 3621 VL - 41 IS - 11 SN - 0146-0404, 0146-0404 KW - Amino Acid Transport System X-AG KW - 0 KW - DNA Primers KW - Dicarboxylic Acids KW - Excitatory Amino Acid Transporter 2 KW - Neurotransmitter Uptake Inhibitors KW - Oligonucleotides, Antisense KW - Pyrrolidines KW - Receptors, Neurotransmitter KW - Glutamic Acid KW - 3KX376GY7L KW - dihydrokainic acid KW - 52497-36-6 KW - pyrrolidine-2,4-dicarboxylic acid KW - 99319-03-6 KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Rats KW - Animals KW - Blotting, Western KW - Rats, Long-Evans KW - Neurotransmitter Uptake Inhibitors -- pharmacology KW - Cell Death KW - Pyrrolidines -- pharmacology KW - Oligonucleotides, Antisense -- pharmacology KW - Dicarboxylic Acids -- pharmacology KW - Chromatography, High Pressure Liquid KW - DNA Primers -- chemistry KW - Receptors, Neurotransmitter -- physiology KW - Kainic Acid -- pharmacology KW - Kainic Acid -- analogs & derivatives KW - Glutamic Acid -- metabolism KW - Vitreous Body -- metabolism KW - ATP-Binding Cassette Transporters -- physiology KW - Receptors, Neurotransmitter -- antagonists & inhibitors KW - Retinal Ganglion Cells -- pathology KW - ATP-Binding Cassette Transporters -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72296150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Depression+of+retinal+glutamate+transporter+function+leads+to+elevated+intravitreal+glutamate+levels+and+ganglion+cell+death.&rft.au=Vorwerk%2C+C+K%3BNaskar%2C+R%3BSchuettauf%2C+F%3BQuinto%2C+K%3BZurakowski%2C+D%3BGochenauer%2C+G%3BRobinson%2C+M+B%3BMackler%2C+S+A%3BDreyer%2C+E+B&rft.aulast=Vorwerk&rft.aufirst=C&rft.date=2000-10-01&rft.volume=41&rft.issue=11&rft.spage=3615&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-12 N1 - Date created - 2000-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pharmacodynamic study of clopidogrel in chronic hemodialysis patients. AN - 72295979; 11005934 AB - Combination antiplatelet agents, particularly aspirin and ticlopidine, have found increased use in the prevention of arterial thrombosis. Clopidogrel, a thienopyridine derivative, like ticlopidine was recently approved by the U.S. Food and Drug Administration (FDA) for the reduction of ischemic events in patients with myocardial infarction, stroke, or peripheral arterial disease and appears to have much less hematologic toxicity than ticlopidine has. Thrombosis of hemodialysis access grafts is a major cause of morbidity in this patient population. Combination antiplatelet agents may be particularly useful in the prevention of hemodialysis access graft thrombosis. In preparation for such a study, we have performed a pharmacodynamic study of the platelet inhibitory effects of clopidogrel in patients on maintenance hemodialysis. Nine chronic hemodialysis patients were studied. Baseline platelet aggregation studies were performed, after which the subjects were begun on clopidogrel 75 mg daily. Platelet aggregation studies were repeated after 14 days of therapy. Drug was stopped and a final set of platelet aggregation studies were performed 7 days later. Because clopidogrel acts by inhibiting adenosine diphosphate (ADP)-induced platelet aggregation, we used ADP as the agonist in the platelet aggregation studies. We also measured the time required to achieve hemostasis after removing the dialysis needles at the termination of a dialysis session. Patients were carefully monitored for any adverse reaction to clopidogrel. Fourteen days' treatment with clopidogrel inhibited ADP-induced platelet aggregation from 48 to 23% with ADP 2 microM (P=0.0113), from 59 to 38% with ADP 5 microM (P=0. 0166), and from 66 to 44% with ADP 10 microM (P=0. 0172). This inhibition of platelet aggregation was reversed 7 days after stopping clopidogrel. Clopidogrel administration did not affect the time required to achieve hemostasis after removal of the dialysis needles. No adverse reactions were noted. No patient had evidence of bleeding, rash or gastro-intestinal (GI) upset. Clopidogrel inhibits ADP-induced platelet aggregation in subjects receiving chronic maintenance hemodialysis. The magnitude of inhibition is similar to that reported in nonuremic subjects with atherosclerosis. This inhibition is reversible within 7 days of discontinuing the drug. No adverse reactions to the drug were noted in this short-term (14-day) trial. JF - Journal of thrombosis and thrombolysis AU - Kaufman, J S AU - Fiore, L AU - Hasbargen, J A AU - O'Connor, T Z AU - Perdriset, G AD - Renal Section, VA Boston Healthcare System, Boston, Massachusetts 02130, USA. kaufman.james@boston.va.gov Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 127 EP - 131 VL - 10 IS - 2 SN - 0929-5305, 0929-5305 KW - Platelet Aggregation Inhibitors KW - 0 KW - Adenosine Diphosphate KW - 61D2G4IYVH KW - clopidogrel KW - A74586SNO7 KW - Ticlopidine KW - OM90ZUW7M1 KW - Index Medicus KW - Thrombosis -- prevention & control KW - Platelet Function Tests KW - Renal Insufficiency -- therapy KW - Dose-Response Relationship, Drug KW - Humans KW - Hemostasis -- drug effects KW - Thrombosis -- etiology KW - Platelet Aggregation Inhibitors -- pharmacology KW - Pilot Projects KW - Chronic Disease KW - Arterial Occlusive Diseases -- etiology KW - Adenosine Diphosphate -- pharmacology KW - Arterial Occlusive Diseases -- prevention & control KW - Renal Insufficiency -- complications KW - Platelet Aggregation -- drug effects KW - Ticlopidine -- pharmacology KW - Ticlopidine -- analogs & derivatives KW - Renal Dialysis -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72295979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+thrombosis+and+thrombolysis&rft.atitle=A+pharmacodynamic+study+of+clopidogrel+in+chronic+hemodialysis+patients.&rft.au=Kaufman%2C+J+S%3BFiore%2C+L%3BHasbargen%2C+J+A%3BO%27Connor%2C+T+Z%3BPerdriset%2C+G&rft.aulast=Kaufman&rft.aufirst=J&rft.date=2000-10-01&rft.volume=10&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Journal+of+thrombosis+and+thrombolysis&rft.issn=09295305&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-09 N1 - Date created - 2001-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Educating Social Workers for an Aging Society: A Vision for the 21st Century AN - 61315247; 200100294 AB - The unprecedented demographic shift to an increasingly older society will have a dramatic impact on individual choices over the life course, the structure of the family, & multiple social institutions. Social work can make unique professional contributions to older persons & the late-life family. Arguing that social work is not adequately prepared to practice in the aging society, challenges to social work are identified, along with ways to address these challenges through educational innovations. 1 Figure, 44 References. Adapted from the source document. JF - Journal of Social Work Education AU - Scharlach, Andrew AU - Damron-Rodriguez, JoAnn AU - Robinson, Barrie AU - Feldman, Ronald AD - Dept Social Welfare, School Public Policy & Social Research, U California, Los Angeles Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 521 EP - 538 VL - 36 IS - 3 SN - 1043-7797, 1043-7797 KW - Twenty First Century KW - Curriculum KW - Social Work Education KW - Demographic Change KW - Aging KW - Gerontology KW - article KW - 6113: social work education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61315247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+Work+Education&rft.atitle=Educating+Social+Workers+for+an+Aging+Society%3A+A+Vision+for+the+21st+Century&rft.au=Scharlach%2C+Andrew%3BDamron-Rodriguez%2C+JoAnn%3BRobinson%2C+Barrie%3BFeldman%2C+Ronald&rft.aulast=Scharlach&rft.aufirst=Andrew&rft.date=2000-10-01&rft.volume=36&rft.issue=3&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+Work+Education&rft.issn=10437797&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-10-30 N1 - Last updated - 2016-09-28 N1 - CODEN - JSWEED N1 - SubjectsTermNotLitGenreText - Demographic Change; Aging; Social Work Education; Gerontology; Curriculum; Twenty First Century ER - TY - JOUR T1 - Pregnancy outcomes among U.S. women Vietnam veterans AN - 18005048; 4773336 AB - Since the 1965-1975 Vietnam War, there has been persistent concern that women who served in the U.S. military in Vietnam may have experienced adverse pregnancy outcomes. We compared self-reported pregnancy outcomes for 4,140 women Vietnam veterans with those of 4,140 contemporary women veterans who were not deployed to Vietnam. As a measure of association, we calculated odds ratios (OR) and 95% confidence intervals (CI) using logistic regression adjusting for age at conception, race, education, military nursing status, smoking, drinking and other exposures during pregnancy. There was no statistically significant association between military service in Vietnam and index pregnancies resulting in miscarriage or stillbirth, low birth weight, pre-term delivery, or infant death. The risk of having children with "moderate-to-severe" birth defects was significantly elevated among Vietnam veterans (adjusted OR = 1.46, 95% CI = 1.06-2.02). The risk of birth defects among index children was significantly associated with mother's military service in Vietnam. JF - American Journal of Industrial Medicine AU - Kang, H K AU - Mahan, C M AU - Lee, KY AU - Magee, CA AU - Mather, SH AU - Matanoski, G AD - Environmental Epidemiology Service, Department of Veterans Affairs, 1120 20th Street N.W., Suite 950, Washington, DC 20036-3406, USA, han.kang@mail.va.gov Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 447 EP - 454 VL - 38 IS - 4 SN - 0271-3586, 0271-3586 KW - veterans KW - man KW - females KW - Vietnam KW - Vietnam War KW - low-birth-weight KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Pregnancy KW - Hazardous materials KW - War KW - Congenital defects KW - Reproduction KW - Females KW - Military KW - Military personnel KW - Occupational exposure KW - X 24240:Miscellaneous KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18005048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Pregnancy+outcomes+among+U.S.+women+Vietnam+veterans&rft.au=Kang%2C+H+K%3BMahan%2C+C+M%3BLee%2C+KY%3BMagee%2C+CA%3BMather%2C+SH%3BMatanoski%2C+G&rft.aulast=Kang&rft.aufirst=H&rft.date=2000-10-01&rft.volume=38&rft.issue=4&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational exposure; Hazardous materials; Military; Pregnancy; Females; Congenital defects; Military personnel; War; Reproduction ER - TY - JOUR T1 - Induction of MMP-9 mediated gelatinolytic activity in human monocytic cells by cell wall components of M. tuberculosis AN - 17688405; 4772078 AB - Mycobacterium tuberculosis (Mtb) infection induces the expression of host matrix metalloIproteinases (MMPs) capable of tissue degradation. We show that infection of mice with Mtb results in differential expression of MMPs in the lung. MMP-9 activity increased by week 1 post-infection, while MMP-2 activity increased after week 2. RT-PCR analysis for gene expression of gelatinases and their respective inhibitors showed: a small increase in MMP-9 by week 1, no change in TIMP-1 and MMP-2, and a significant decrease in TIMP-2 by week 4. The increase in MMP-2 could be due to a decrease in TIMP-2 expression. Addition of 4-aminophenylmercuric acid to lung extracts increased MMP-9 activity, suggesting that its regulation could be due to endogenous activation by proteases. In vitro, attenuated and virulent Mtb strains equally induced MMP-9 expression in U937 monocytes. The inducer of MMP-9 in Mtb was present in culture filtrates, and was active after paraformaldehyde fixation. LAM stimulated MMP-9 expression in THP-1 cells, but not U937 cells. However, LAM-free extracts also induced MMP-9 activity in THP-1 cells. Fractionation of Mtb extracts by chromatography revealed fractions of 17 and 156 kDa with MMP-9 inducing activity. In conclusion, LAM and other components of Mtb induce the expression of MMP-9. JF - Microbial Pathogenesis AU - Rivera-Marrero, CA AU - Schuyler, W AU - Roser, S AU - Roman, J AD - Department of Medicine, Pulmonary and Critical Care Division, Atlanta, 30033, GA, U.S.A., roman-rodriguez.jesse@atlanta.va.gov Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 231 EP - 244 PB - Academic Press VL - 29 IS - 4 SN - 0882-4010, 0882-4010 KW - gelatinase KW - matrix metalloproteinase KW - Microbiology Abstracts B: Bacteriology KW - Gene expression KW - Metalloproteinase KW - Cell walls KW - Mycobacterium tuberculosis KW - J 02728:Enzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17688405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Induction+of+MMP-9+mediated+gelatinolytic+activity+in+human+monocytic+cells+by+cell+wall+components+of+M.+tuberculosis&rft.au=Rivera-Marrero%2C+CA%3BSchuyler%2C+W%3BRoser%2C+S%3BRoman%2C+J&rft.aulast=Rivera-Marrero&rft.aufirst=CA&rft.date=2000-10-01&rft.volume=29&rft.issue=4&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Metalloproteinase; Cell walls; Gene expression ER - TY - JOUR T1 - Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model AN - 17641513; 4784082 AB - ABT-773, a new ketolide antimicrobial agent, was evaluated in comparison to clarithromycin (CLA) in vitro against Mycobacterium avium complex (MAC) and in a beige mouse model of disseminated MAC infection. The MICs at which 50 and 90% of the isolates tested were inhibited were 2 and 4 mu g/ml, respectively, for CLA and 8 and 16 mu g/ml, respectively, for ABT-773. Eight CLA-resistant isolates were found to be resistant to ABT-773 (MICs > 64 mu g/ml). In the in vivo study mice were treated with ABT-773 (50, 100, and 200 mg/kg of body weight) or CLA (200 mg/kg). Both ABT-773 (100 and 200 mg/kg) and CLA significantly decreased the viable cell counts in spleens and lungs. ABT-773 (200 mg/kg) and CLA had similar activities in lungs, but the former was more active in spleens. JF - Antimicrobial Agents & Chemotherapy AU - Cynamon, M H AU - Carter, J L AU - Shoen, C M AD - Department of Medicine, Veterans Affairs Medical Center, 800 Irving Ave., Syracuse, NY 13210, USA, Michael.Cynamon@Med.VA.Gov Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 2895 EP - 2896 VL - 44 IS - 10 SN - 0066-4804, 0066-4804 KW - ABT-773 KW - Microbiology Abstracts B: Bacteriology KW - Clarithromycin KW - Mycobacterium avium KW - Drug resistance KW - Animal models KW - Drug sensitivity testing KW - Antibacterial agents KW - Minimum inhibitory concentration KW - J 02786:Macrolide antibiotics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17641513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Activity+of+ABT-773+against+Mycobacterium+avium+complex+in+the+beige+mouse+model&rft.au=Cynamon%2C+M+H%3BCarter%2C+J+L%3BShoen%2C+C+M&rft.aulast=Cynamon&rft.aufirst=M&rft.date=2000-10-01&rft.volume=44&rft.issue=10&rft.spage=2895&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.44.10.2895-2896.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium avium; Antibacterial agents; Clarithromycin; Drug sensitivity testing; Minimum inhibitory concentration; Drug resistance; Animal models DO - http://dx.doi.org/10.1128/AAC.44.10.2895-2896.2000 ER - TY - JOUR T1 - Diesel exhaust exposure and lung cancer: Adjustment for the effect of smoking in a retrospective cohort study AN - 17630402; 4773309 AB - The extent that cigarette smoking may confound the relationship between diesel exhaust exposure and lung cancer was assessed in a retrospective cohort study of 55,395 U.S. railroad workers followed from 1959 to 1976. The relative risk (RR) of lung cancer due to diesel exhaust was indirectly adjusted using job-specific smoking data from a case-control study of railroad workers who died between 1981-1982 and from a survey of 514 living workers from an active railroad in 1982. Adjustment factors were developed based on the distribution of job-specific smoking rates. The unadjusted RR for lung cancer was 1.58 (95% CI = 1.14-2.20) for workers aged 40-44 in 1959, who experienced the longest possible duration of exposure, and the smoking adjusted RR was 1.44 (1.01-2.05). After considering differences in smoking rates between workers exposed and unexposed to diesel exhaust in a relatively large blue-collar cohort, there were still elevated risks of lung cancer in workers in jobs with diesel exhaust exposure. JF - American Journal of Industrial Medicine AU - Larkin, E K AU - Smith, T J AU - Stayner, L AU - Rosner, B AU - Speizer, F E AU - Garshick, E AD - MOH Medical and Research Service, VA Boston Health Care Systems, 1400 UFW Parkway, Boston, MA 02132, USA, eric.garshick@med.va.gov Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 399 EP - 409 VL - 38 IS - 4 SN - 0271-3586, 0271-3586 KW - man KW - railroads KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts; Risk Abstracts KW - lung cancer KW - Railroads KW - Cigarette smoking KW - Occupational exposure KW - Exhaust emissions KW - Lung cancer KW - Exhausts KW - Diesel KW - Diesel engines KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17630402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Diesel+exhaust+exposure+and+lung+cancer%3A+Adjustment+for+the+effect+of+smoking+in+a+retrospective+cohort+study&rft.au=Larkin%2C+E+K%3BSmith%2C+T+J%3BStayner%2C+L%3BRosner%2C+B%3BSpeizer%2C+F+E%3BGarshick%2C+E&rft.aulast=Larkin&rft.aufirst=E&rft.date=2000-10-01&rft.volume=38&rft.issue=4&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2F1097-0274%28200010%2938%3A43.3.CO%3B2-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lung cancer; Cigarette smoking; Occupational exposure; Diesel engines; Exhaust emissions; Railroads; Exhausts; Diesel; lung cancer DO - http://dx.doi.org/10.1002/1097-0274(200010)38:4<399::AID-AJIM5>3.3.CO;2-4 ER - TY - JOUR T1 - Improving Residents' Compliance With Standards of Ambulatory Care. Results From the VA Cooperative Study on Computerized Reminders AN - 18339776; 4862627 AB - Computerized systems to remind physicians to provide appropriate care have not been widely evaluated in large numbers of patients in multiple clinical settings. To examine whether a computerized reminder system operating in multiple Veterans Affairs (VA) ambulatory care clinics improves resident physician compliance with standards of ambulatory care. A total of 275 resident physicians at 12 VA medical centers were randomly assigned in firms or half-day clinic blocks to either a reminder group (n = 132) or a control group (n = 143). During a 17-month study period (January 31, 1995-June 30, 1996), the residents cared for 12,989 unique patients for whom at least 1 of the studied standards of care (SOC) was applicable. Compliance with 13 SOC, tracked using hospital databases and encounter forms completed by residents, compared between residents in the reminder group vs those in the control group. Measuring compliance as the proportion of patients in compliance with all applicable SOC by their last visit during the study period, the reminder group had statistically significantly higher rates of compliance than the control group for all standards combined (58.8% vs 53.5%; odds ratio [OR], 1.24; 95% confidence interval [CI], 1.08-1.42; P = .002) and for 5 of the 13 standards examined individually. Measuring compliance as the proportion of all visits for which care was indicated in which residents provided proper care, the reminder group also had statistically significantly higher rates of compliance than the control group for all standards combined (17.9% vs 12.2%; OR, 1.57; 95% CI, 1.45-1.71; P<.001) and for 9 of the 13 standards examined individually. The benefit of reminders, however, declined throughout the course of the study, even though the reminders remained active. Our data indicate that reminder systems installed at multiple sites can improve residents' compliance to multiple SOC. The benefits of such systems, however, appear to deteriorate over time. Future research needs to explore methods to better sustain the benefits of reminders. JF - Journal of the American Medical Association AU - Demakis, J G AU - Beauchamp, C AU - Cull, W L AU - Denwood, R AU - Eisen, SA AU - Lofgren, R AU - Nichol, K AU - Woolliscroft, J AU - Henderson, W G AD - (151K), Hines VA Hospital, PO Box 5000, Hines, IL 60141, USA, Henderson@research.hines.med.va.gov Y1 - 2000/09/20/ PY - 2000 DA - 2000 Sep 20 SP - 1411 EP - 1416 VL - 284 IS - 11 SN - 0098-7484, 0098-7484 KW - Health & Safety Science Abstracts KW - Health care KW - Quality control KW - Compliance KW - Standards KW - H 13000:Medical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18339776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Association&rft.atitle=Improving+Residents%27+Compliance+With+Standards+of+Ambulatory+Care.+Results+From+the+VA+Cooperative+Study+on+Computerized+Reminders&rft.au=Demakis%2C+J+G%3BBeauchamp%2C+C%3BCull%2C+W+L%3BDenwood%2C+R%3BEisen%2C+SA%3BLofgren%2C+R%3BNichol%2C+K%3BWoolliscroft%2C+J%3BHenderson%2C+W+G&rft.aulast=Demakis&rft.aufirst=J&rft.date=2000-09-20&rft.volume=284&rft.issue=11&rft.spage=1411&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Health care; Standards; Quality control; Compliance ER - TY - JOUR T1 - Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use. AN - 72278141; 10995858 AB - Using a model of recreational cocaine consumption, we have determined in four rhesus monkeys the impact of self-administered cocaine on mesolimbic and sensorimotor striatal dopaminergic neurotransmission. The effects of cocaine repeated within a self-administration session and across multiple sessions over a 6 month period were determined by the use of fixed-ratio self-administration and microdialysis procedures. The exposure to cocaine was modest, with at most two 0.5 mg/kg infusions permitted in each weekly session. Within a cocaine self-administration session, acute tolerance to the ability of cocaine to elevate extracellular striatal dopamine was observed. Over a period of 6 months of repeated self-administration, there was a significant increase in the impact of a fixed dose on extracellular dopamine, indicating that neurochemical sensitization to the effects of self-administered cocaine occurs in primates. A pronounced dopaminergic response to noncontingent cocaine was also observed, with no increases in extracellular dopamine in response to an unexpected saline substitution, indicating that the neurochemical response to self-administered cocaine is primarily caused by direct pharmacological effects of the drug rather than by conditioning to external environmental cues. These results highlight the contrast in time-dependent changes in neurochemical responsiveness to cocaine, depending on whether within-session or between-session comparisons are made. They also demonstrate that recreational levels of cocaine consumption can result in neurochemical sensitization, an enduring change in brain function that may contribute to addiction. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Bradberry, C W AD - Departments of Psychiatry and Laboratory Medicine, West Haven Veterans Administration Hospital and Yale University School of Medicine, West Haven, Connecticut 06516, USA. charles.bradberry@yale.edu Y1 - 2000/09/15/ PY - 2000 DA - 2000 Sep 15 SP - 7109 EP - 7115 VL - 20 IS - 18 SN - 0270-6474, 0270-6474 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Acute Disease KW - Regression Analysis KW - Animals KW - Analysis of Variance KW - Extracellular Space -- chemistry KW - Corpus Striatum -- metabolism KW - Disease Models, Animal KW - Microdialysis KW - Behavior, Animal -- drug effects KW - Drug Tolerance KW - Self Administration KW - Extracellular Space -- metabolism KW - Chronic Disease KW - Macaca mulatta KW - Male KW - Synaptic Transmission -- drug effects KW - Dopamine -- metabolism KW - Dopamine -- analysis KW - Cocaine-Related Disorders -- metabolism KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72278141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Acute+and+chronic+dopamine+dynamics+in+a+nonhuman+primate+model+of+recreational+cocaine+use.&rft.au=Bradberry%2C+C+W&rft.aulast=Bradberry&rft.aufirst=C&rft.date=2000-09-15&rft.volume=20&rft.issue=18&rft.spage=7109&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-18 N1 - Date created - 2000-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment of uninvestigated dyspepsia with cisapride for patients with negative Helicobacter pylori serologies. AN - 85349485; pmid-11007220 AB - OBJECTIVE: The aim of this study was to compare symptoms for patients with uninvestigated dyspepsia and a negative Helicobacter pylori serology who were treated with cisapride or placebo. METHODS: Helicobacter pylori-seronegative patients with chronic dyspepsia were randomized to receive cisapride 10 mg t.i.d. or placebo t.i.d. for 30 days. Symptom scores were performed 1 month and 3 months after randomization. Outcomes measured were dyspepsia symptom scores and a treatment "success" variable defined as absence of symptoms or decrease in the most severe individual symptom by two grades. RESULTS: A total of 60 patients were randomized; 56 completed the 1-month follow-up and 40 completed the 3-month follow-up interview. The mean score for all patients at the time of entry was 11.0 and declined to 8.3 and 8.2 at 1 and 3 months, respectively, after randomization. At 1 month and 3 months after randomization, there was no significant difference in the number of patients meeting the "success" variable for patients receiving cisapride as compared to placebo. The mean decline in symptom severity scores was not significantly different for patients receiving placebo or cisapride at 1 month (mean, -2.8 vs -3.1; difference = 0.3, p = 0.74) or 3 months (-3.1 vs -2.6, difference = -0.5, p = 0.58) after randomization. CONCLUSIONS: No significant difference in the severity of dyspeptic symptoms was found for patients receiving cisapride as compared to placebo in the setting of uninvestigated dyspepsia and a negative Helicobacter pylori serology. JF - The American journal of gastroenterology AU - Kearney, D J AU - Avins, A L AU - McQuaid, K R AD - San Francisco Veterans Administration Medical Center, University of California-San Francisco, USA. Y1 - 2000/09// PY - 2000 DA - Sep 2000 SP - 2212 EP - 2217 VL - 95 IS - 9 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Severity of Illness Index KW - Administration, Oral KW - Helicobacter Infections -- diagnosis KW - Diagnosis, Differential KW - Gastrointestinal Agents -- administration & dosage KW - Humans KW - Cisapride -- administration & dosage KW - Helicobacter Infections -- microbiology KW - Dyspepsia -- drug therapy KW - Dyspepsia -- etiology KW - Immunoglobulin G -- immunology KW - Adult KW - Cisapride -- therapeutic use KW - Gastrointestinal Agents -- therapeutic use KW - Male KW - Female KW - Dyspepsia -- diagnosis KW - Antibodies, Bacterial -- analysis KW - Helicobacter pylori -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85349485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Treatment+of+uninvestigated+dyspepsia+with+cisapride+for+patients+with+negative+Helicobacter+pylori+serologies.&rft.au=Kearney%2C+D+J%3BAvins%2C+A+L%3BMcQuaid%2C+K+R&rft.aulast=Kearney&rft.aufirst=D&rft.date=2000-09-01&rft.volume=95&rft.issue=9&rft.spage=2212&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - The role of physical proximity in nosocomial diarrhea. AN - 72408418; 11017821 AB - To examine physical proximity as a risk factor for the nosocomial acquisition of Clostridium difficile-associated diarrhea (CDAD) and of antibiotic-associated diarrhea (AAD), we assessed a retrospective cohort of 2859 patients admitted to a community hospital from 1 March 1987 through 31 August 1987. Of these patients, 68 had nosocomial CDAD and 54 had nosocomial AAD. In multivariate analysis, physical proximity to a patient with CDAD (relative risk [RR], 1.86; 95% confidence interval [CI], 1.06-3.28), exposure to clindamycin (RR, 4.22; 95% CI, 2.11-8.45), and the number of antibiotics taken (RR, 1.49; 95% CI, 1.23-1.81) were significant. For patients with nosocomial AAD, exposure to a roommate with AAD (RR, 3.94; 95% CI, 1. 27-12.24), a stay in an intensive care unit or cardiac care unit (RR, 1.93; 95% CI, 1.05-3.53), and the number of antibiotics taken (RR, 2.01; 95% CI, 1.67-2.40) were significant risk factors. Physical proximity may be an independent risk factor for acquisition of nosocomial CDAD and AAD. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Chang, V T AU - Nelson, K AD - Department of Medicine, Veterans Affairs New Jersey Health Care System at East Orange/University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ 07019, USA. victor.chang@med. va.gov Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 717 EP - 722 VL - 31 IS - 3 SN - 1058-4838, 1058-4838 KW - Anti-Bacterial Agents KW - 0 KW - Index Medicus KW - Humans KW - Anti-Bacterial Agents -- adverse effects KW - Retrospective Studies KW - Aged KW - Clostridium Infections -- microbiology KW - Multivariate Analysis KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Cohort Studies KW - Clostridium difficile KW - Middle Aged KW - Female KW - Hospitals, Community -- statistics & numerical data KW - Male KW - Diarrhea -- chemically induced KW - Environmental Exposure KW - Cross Infection -- microbiology KW - Diarrhea -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72408418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=The+role+of+physical+proximity+in+nosocomial+diarrhea.&rft.au=Chang%2C+V+T%3BNelson%2C+K&rft.aulast=Chang&rft.aufirst=V&rft.date=2000-09-01&rft.volume=31&rft.issue=3&rft.spage=717&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-22 N1 - Date created - 2000-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence and diagnostic value of precordial murmurs for valvular regurgitation in obese patients treated with dexfenfluramine. AN - 72293715; 11009272 AB - Echocardiography is recommended for the detection of valvular regurgitation in asymptomatic users of anorexigens with a heart murmur. To determine the prevalence and diagnostic value of heart murmurs for valvular regurgitation, 223 patients receiving dexfenfluramine therapy for 6.9 months and 189 matched controls underwent history and cardiac auscultation by experienced noncardiologists unaware of echocardiography. Color Doppler echocardiograms were interpreted by 3 observers unaware of patients' clinical data. The frequency of at least mild regurgitation of any valve and abnormal regurgitation (moderate mitral or tricuspid or mild aortic regurgitation) were determined. Heart murmurs heard in 31 dexfenfluramine users (14%) and in 20 controls (11%) were all systolic and of grade I to II/VI intensity. Mild or worse regurgitation of any valve showed a trend in patients (18% vs 11.6% in controls, odds ratio [OR] 1.66, confidence interval [CI] 0.95 to 2.9, p = 0.08), but abnormal regurgitation (includes Food and Drug Administration grade regurgitation) was more common in patients (9% vs 3% in controls, OR 3.0, CI 1.18 to 7.65, p = 0.02). In dexfenfluramine users, heart murmurs were associated with at least mild or abnormal regurgitation (OR 3.1 and 3.05, 95% CI 1.34 to 7.13 and 1.1 to 8.67; p = 0.008 and 0.036, respectively), had a specificity of 89% and 88%, negative predictive value of 85% and 93%, but sensitivity of 37% and 30%, and positive predictive value of 35% and 19%, respectively. Most valves missed by cardiac auscultation had normal morphology and mild regurgitation. Finally, heart murmurs had better diagnostic value for either type of valvular regurgitation than heart murmurs and clinical variables or clinical variables alone. In summary, in dexfenfluramine users the prevalence of heart murmurs was low and their absence predicted absence of mild or worse regurgitation of any valve or abnormal valvular regurgitation. Therefore, cardiac auscultation should be the screening method of choice for detecting valvular regurgitation in users of anorexigens. JF - The American journal of cardiology AU - Roldan, C A AU - Gill, E A AU - Shively, B K AD - Cardiology Division of the Veterans Affairs Medical Center and University of New Mexico, Albuquerque 87108, USA. roldan.carlos-a@albuquerque.va.gov Y1 - 2000/09/01/ PY - 2000 DA - 2000 Sep 01 SP - 535 EP - 539 VL - 86 IS - 5 SN - 0002-9149, 0002-9149 KW - Serotonin Receptor Agonists KW - 0 KW - Dexfenfluramine KW - E35R3G56OV KW - Abridged Index Medicus KW - Index Medicus KW - Echocardiography, Doppler, Color KW - Humans KW - Case-Control Studies KW - Middle Aged KW - Heart Auscultation KW - Male KW - Female KW - Prevalence KW - Obesity -- drug therapy KW - Heart Valve Diseases -- diagnosis KW - Serotonin Receptor Agonists -- adverse effects KW - Heart Valve Diseases -- complications KW - Heart Murmurs -- diagnosis KW - Heart Murmurs -- etiology KW - Dexfenfluramine -- adverse effects KW - Heart Valve Diseases -- chemically induced KW - Obesity -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72293715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Prevalence+and+diagnostic+value+of+precordial+murmurs+for+valvular+regurgitation+in+obese+patients+treated+with+dexfenfluramine.&rft.au=Roldan%2C+C+A%3BGill%2C+E+A%3BShively%2C+B+K&rft.aulast=Roldan&rft.aufirst=C&rft.date=2000-09-01&rft.volume=86&rft.issue=5&rft.spage=535&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-05 N1 - Date created - 2000-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. AN - 72240307; 10977010 AB - Of patients who are prescribed metformin, 10-30% have evidence of reduced vitamin B12 absorption. B12-intrinsic factor complex uptake by ileal cell surface receptors is known to be a process dependent on calcium availability Metformin affects calcium-dependent membrane action. The objective of this study was to determine the magnitude and mechanism of the reduction in serum vitamin B12 after metformin administration. A comparative study design was employed using 2 groups (metformin and control). A total of 21 patients with type 2 diabetes received sulfonylurea therapy; 14 of these 21 patients were switched to metformin. Monthly serum total vitamin B12 measurements and holotranscobalamin (holoTCII) (B12-TCII) were performed. After 3 months of metformin therapy, oral calcium supplementation was administered. Serial serum vitamin B12 determinations revealed a similar decline in vitamin B12 and holoTCII. Oral calcium supplementation reversed the metformin-induced serum holoTCII depression. Patients receiving metformin have diminished B12 absorption and low serum total vitamin B12 and TCII-B12 levels because of a calcium-dependent ileal membrane antagonism, an effect reversed with supplemental calcium. JF - Diabetes care AU - Bauman, W A AU - Shaw, S AU - Jayatilleke, E AU - Spungen, A M AU - Herbert, V AD - Department of Medicine, Mount Sinai School of Medicine, New York, USA. bauman.william@bronx.va.gov Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 1227 EP - 1231 VL - 23 IS - 9 SN - 0149-5992, 0149-5992 KW - Calcium, Dietary KW - 0 KW - Hypoglycemic Agents KW - Metformin KW - 9100L32L2N KW - Calcium Carbonate KW - H0G9379FGK KW - Vitamin B 12 KW - P6YC3EG204 KW - Index Medicus KW - Ethnic Groups KW - Humans KW - Adult KW - Middle Aged KW - Dietary Supplements KW - Male KW - Calcium Carbonate -- therapeutic use KW - Hypoglycemic Agents -- adverse effects KW - Metformin -- adverse effects KW - Vitamin B 12 -- blood KW - Intestinal Absorption -- drug effects KW - Calcium, Dietary -- therapeutic use KW - Vitamin B 12 -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72240307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+care&rft.atitle=Increased+intake+of+calcium+reverses+vitamin+B12+malabsorption+induced+by+metformin.&rft.au=Bauman%2C+W+A%3BShaw%2C+S%3BJayatilleke%2C+E%3BSpungen%2C+A+M%3BHerbert%2C+V&rft.aulast=Bauman&rft.aufirst=W&rft.date=2000-09-01&rft.volume=23&rft.issue=9&rft.spage=1227&rft.isbn=&rft.btitle=&rft.title=Diabetes+care&rft.issn=01495992&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-21 N1 - Date created - 2000-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Race, age, and back pain as factors in completion of residential substance abuse treatment by veterans. AN - 72239861; 10970920 AB - Variables associated with successful completion of residential substance abuse treatment were identified. The records of 340 veterans admitted to a 120-day substance abuse treatment program were retrospectively analyzed. The likelihood of successful treatment completion was calculated as a function of race, age, gender, psychiatric diagnosis, past suicide attempts, homelessness, legal history, childhood physical or sexual abuse, parental history of addiction, multiple substance dependence, medical problems, and the race of the therapist. Univariate analysis and logistic regression analysis were used to identify variables that were significant predictors of treatment completion. Overall, 66 percent of veterans completed the program. Eighty-two percent of the veterans admitted to the program were black, and 16 percent were white. The completion rate of black veterans (71 percent) was significantly higher than that of white veterans (49 percent). Veterans completing treatment were significantly more likely to be older, by an average of two years, than those who did not complete treatment. The association between younger age and failure to complete the program was largely accounted for by younger black veterans. Veterans with back pain were significantly less likely to complete treatment than those without back pain. Completion rates did not vary by the other variables examined. In the regression analysis that included age, race, and back pain, each variable, when adjusted by the other variables, was a significant predictor of completion. White patients were less likely to complete residential substance abuse treatment in a program in which the majority of both therapists and patients were black. Younger black veterans and those with back pain were also less likely to complete treatment. JF - Psychiatric services (Washington, D.C.) AU - Stack, K AU - Cortina, J AU - Samples, C AU - Zapata, M AU - Arcand, L F AD - Hampton VA Hospital, VA 23667, USA. stack@med.va.gov Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 1157 EP - 1161 VL - 51 IS - 9 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - Age Factors KW - Humans KW - Adult KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - African Americans -- psychology KW - European Continental Ancestry Group -- psychology KW - African Americans -- statistics & numerical data KW - Veterans -- psychology KW - European Continental Ancestry Group -- statistics & numerical data KW - Substance-Related Disorders -- rehabilitation KW - Back Pain -- therapy KW - Substance-Related Disorders -- epidemiology KW - Residential Treatment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72239861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Race%2C+age%2C+and+back+pain+as+factors+in+completion+of+residential+substance+abuse+treatment+by+veterans.&rft.au=Stack%2C+K%3BCortina%2C+J%3BSamples%2C+C%3BZapata%2C+M%3BArcand%2C+L+F&rft.aulast=Stack&rft.aufirst=K&rft.date=2000-09-01&rft.volume=51&rft.issue=9&rft.spage=1157&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-12 N1 - Date created - 2000-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Matching alcoholics to treatment. Failure to replicate finding of an earlier study. AN - 72217202; 10963930 AB - The purpose of the present study was to investigate whether sociopathic alcoholics respond differentially to different types of treatment. An earlier study found that alcoholics with antisocial personality disorder had somewhat better outcomes if treated in individually focused versus relationship-focused cognitive-behavioral treatment. The present study was designed to attempt to replicate these findings. One hundred and forty-nine alcoholics (42 of whom scored high on a measure of sociopathy) were randomly assigned to receive either individually focused cognitive-behavioral treatment or a relationship-focused community reinforcement approach. Follow-up evaluations were conducted every 4 months for 2 years. Results failed to support the study hypothesis. Drinking outcomes were similar for sociopathic alcoholics in both treatment conditions. Directions for future research are identified. JF - Journal of substance abuse treatment AU - Kalman, D AU - Longabaugh, R AU - Clifford, P R AU - Beattie, M AU - Maisto, S A AD - Center for Alcohol and Addiction Studies, Brown University, 02912, Providence, RI, USA. Kalman.David@bedford.va.gov Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 183 EP - 187 VL - 19 IS - 2 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Treatment Failure KW - Behavior Therapy KW - Humans KW - Reinforcement (Psychology) KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Alcoholism -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72217202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Matching+alcoholics+to+treatment.+Failure+to+replicate+finding+of+an+earlier+study.&rft.au=Kalman%2C+D%3BLongabaugh%2C+R%3BClifford%2C+P+R%3BBeattie%2C+M%3BMaisto%2C+S+A&rft.aulast=Kalman&rft.aufirst=D&rft.date=2000-09-01&rft.volume=19&rft.issue=2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-25 N1 - Date created - 2000-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of gastrin-releasing peptide and its receptor aberrantly expressed by human colon cancer cell lines. AN - 72203273; 10953054 AB - Gastrin-releasing peptide (GRP) is a mitogen and morphogen important in the development of human colon cancers. Although epithelial cells lining the colon do not normally express GRP or its receptor (GRP-R), most human tumors express GRP-R mRNA. Yet functional protein has only been detected in 24 to 40% of colon cancers. To elucidate the reason for the difference between the expression of GRP/GRP-R mRNA and protein, we studied nine human colon cancer cell lines. Quantitative polymerase chain reaction revealed that all colon cancer cell lines expressed similar amounts of mRNA for both GRP as well as GRP-R. Yet binding studies using (125)I-Tyr(4)-bombesin detected functional receptors on only five of the nine cell lines studied. Conformational fragment-length polymorphism analysis indicated that although mRNA for the ligand GRP was never mutated, mRNA for the GRP-R was always mutated. Sequencing revealed that the message for GRP-R contained between two and seven separate mutations at the nucleotide level. This resulted in 14 separate coding mutations, 2 of which were observed in more than one cell line. Each mutation was individually recreated by site-directed mutagenesis and studied in transiently transfected Chinese hamster ovary-K1 cells. Alteration of Pro(145) into a tyrosine, of Val(317) into a glutamic acid, and insertion of a 32-nucleotide segment resulting in a frameshift distal to Asp(137) all resulted in GRP receptors incapable of binding ligand. Thus, these data indicate that human colon cancers commonly express GRP and GRP-R mRNA but that receptor mutations account for the failure of functional protein to be generated. JF - Molecular pharmacology AU - Carroll, R E AU - Ostrovskiy, D AU - Lee, S AU - Danilkovich, A AU - Benya, R V AD - Department of Medicine, University of Illinois at Chicago and Chicago Veterans Administration Medical Center (West Side Division), Chicago, Illinois 60612, USA. Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 601 EP - 607 VL - 58 IS - 3 SN - 0026-895X, 0026-895X KW - RNA, Messenger KW - 0 KW - Receptors, Bombesin KW - Gastrin-Releasing Peptide KW - 80043-53-4 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - Tumor Cells, Cultured KW - Transfection KW - Humans KW - Molecular Sequence Data KW - CHO Cells KW - Caco-2 Cells KW - Amino Acid Sequence KW - RNA, Messenger -- biosynthesis KW - Protein Conformation KW - Cricetinae KW - Binding Sites KW - Receptors, Bombesin -- genetics KW - Gastrin-Releasing Peptide -- genetics KW - Gastrin-Releasing Peptide -- biosynthesis KW - Colonic Neoplasms -- metabolism KW - Receptors, Bombesin -- biosynthesis KW - Receptors, Bombesin -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72203273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Characterization+of+gastrin-releasing+peptide+and+its+receptor+aberrantly+expressed+by+human+colon+cancer+cell+lines.&rft.au=Carroll%2C+R+E%3BOstrovskiy%2C+D%3BLee%2C+S%3BDanilkovich%2C+A%3BBenya%2C+R+V&rft.aulast=Carroll&rft.aufirst=R&rft.date=2000-09-01&rft.volume=58&rft.issue=3&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-25 N1 - Date created - 2000-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Latex allergy and the healthcare worker. AN - 70529440; 11854963 AB - The purpose of this article is to describe the clinical manifestations and treatment of latex allergy. A discussion of the identification of latex-sensitized staff and available diagnostic tests is presented. Emphasis is placed on the healthcare worker's role in preventing future latex allergy cases from developing. JF - Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates AU - Wai, D M AD - VA Connecticut Healthcare System, 874 Hill Street, Hamden, CT 06514, USA. wai.donna_e@west-haven.va.gov PY - 2000 SP - 226 EP - 231 VL - 23 IS - 5 SN - 1042-895X, 1042-895X KW - Nursing KW - Radioallergosorbent Test KW - Occupational Health KW - Information Services KW - Nursing Assessment KW - Skin Tests KW - Risk Factors KW - Humans KW - Primary Prevention -- methods KW - Internet KW - Risk Assessment KW - Latex Hypersensitivity -- etiology KW - Occupational Diseases -- diagnosis KW - Occupational Exposure -- statistics & numerical data KW - Latex Hypersensitivity -- epidemiology KW - Occupational Diseases -- etiology KW - Latex Hypersensitivity -- diagnosis KW - Latex Hypersensitivity -- therapy KW - Occupational Exposure -- prevention & control KW - Health Personnel KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- therapy KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70529440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology+nursing+%3A+the+official+journal+of+the+Society+of+Gastroenterology+Nurses+and+Associates&rft.atitle=Latex+allergy+and+the+healthcare+worker.&rft.au=Wai%2C+D+M&rft.aulast=Wai&rft.aufirst=D&rft.date=2000-09-01&rft.volume=23&rft.issue=5&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Gastroenterology+nursing+%3A+the+official+journal+of+the+Society+of+Gastroenterology+Nurses+and+Associates&rft.issn=1042895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-14 N1 - Date created - 2002-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CLIC-1 Functions as a Chloride Channel When Expressed and Purified from Bacteria AN - 17689484; 4781383 AB - CLIC-1 is a member of a family of proteins related to the bovine intracellular chloride channel p64 which has been proposed to function as a chloride channel. We expressed CLIC-1 as a glutathione S-transferase fusion protein in bacteria. The fusion protein was purified by glutathione affinity, and CLIC-1 was released from its fusion partner by digestion with thrombin. After further purification, CLIC-1 was reconstituted into phospholipid vesicles by detergent dialysis. Chloride permeability of reconstituted vesicles was assessed using a valinomycin dependent chloride efflux assay, demonstrating increased vesicular chloride permeability with CLIC-1 compared with control. CLIC-1-dependent chloride permeability was inhibited by indanyloxyacetic acid-94 with an apparent IC sub(50) of 8.6 mu M. The single channel properties of CLIC-1 were determined using the planar lipid bilayer technique. We found that CLIC-1 forms a voltage-dependent, Cl-selective channel with a rectifying current-voltage relationship and single channel conductances of 161 plus or minus 7.9 and 67.5 plus or minus 6.9 picosiemens in symmetric 300 and 150 mM KCl, respectively. The anion selectivity of this activity is Br approximately Cl > I. The open probability of CLIC-1 channels in planar bilayers was decreased by indanyloxyacetic acid-94 with an apparent IC sub(50) of 86 mu M at 50 mV. These data convincingly demonstrate that CLIC-1 is capable of forming a novel, chloride-selective channel in the absence of other subunits or proteins. JF - Journal of Biological Chemistry AU - Tulk, B M AU - Schlesinger, PH AU - Kapadia, SA AU - Edwards, J C AD - Department of Internal Medicine, St. Louis University, USA, John.Edwards3@med.va.gov Y1 - 2000/09/01/ PY - 2000 DA - 2000 Sep 01 SP - 26986 EP - 26993 VL - 275 IS - 35 SN - 0021-9258, 0021-9258 KW - in vitro KW - CLIC-1 protein KW - chloride channels KW - p64 protein KW - Microbiology Abstracts B: Bacteriology KW - Membrane vesicles KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17689484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=CLIC-1+Functions+as+a+Chloride+Channel+When+Expressed+and+Purified+from+Bacteria&rft.au=Tulk%2C+B+M%3BSchlesinger%2C+PH%3BKapadia%2C+SA%3BEdwards%2C+J+C&rft.aulast=Tulk&rft.aufirst=B&rft.date=2000-09-01&rft.volume=275&rft.issue=35&rft.spage=26986&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Membrane vesicles ER - TY - JOUR T1 - Galanin-1 receptor up-regulation mediates the excess colonic fluid production caused by infection with enteric pathogens AN - 17689413; 4773712 AB - Galanin is widely distributed in enteric nerve terminals lining the gastrointestinal tract. We previously showed that pathogenic Escherichia coli, but not normal commensal organisms, increase galanin-1 receptor expression by epithelial cells lining the colon (i.e., colonocytes). When present, galanin-1 receptor activation by ligand causes colonocyte Cl super(-) secretion. We herein demonstrate that disparate pathogens including Salmonella typhimurium and Shigella flexerii also increase colonocyte galanin-1 receptor expression, whose activation is responsible for a principal component of the increased colonic fluid secretion observed. Although eliminating the GAL1R gene by homologous recombination does not alter basal colonic fluid secretion, removal of one or both alleles completely attenuates the increase in fluid secretion due to infection with enteric pathogens. Galanin-1 receptor up-regulation therefore represents a novel mechanism accounting for the increased colonic fluid secretion observed in infectious diarrhea due to several different pathogens. JF - Nature Medicine AU - Matkowskyj, KA AU - Danilkovich, A AU - Marrero, J AU - Savkovic, S D AU - Hecht, G AU - Benya, R V AD - Departments of Medicine, University of Illinois at Chicago and Chicago Veterans Administration Medical Center (West Side Division), Chicago, Illinois 60612, USA, rvbenya@uic.edu Y1 - 2000/09// PY - 2000 DA - Sep 2000 SP - 1048 EP - 1051 VL - 6 IS - 9 SN - 1078-8956, 1078-8956 KW - Microbiology Abstracts B: Bacteriology KW - Galanin KW - Diarrhea KW - Nerve endings KW - Shigellosis KW - Salmonellosis KW - Shigella flexneri KW - Escherichia coli KW - Galanin receptors KW - Gastrointestinal tract KW - Salmonella typhimurium KW - J 02846:Gastrointestinal tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17689413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Galanin-1+receptor+up-regulation+mediates+the+excess+colonic+fluid+production+caused+by+infection+with+enteric+pathogens&rft.au=Matkowskyj%2C+KA%3BDanilkovich%2C+A%3BMarrero%2C+J%3BSavkovic%2C+S+D%3BHecht%2C+G%3BBenya%2C+R+V&rft.aulast=Matkowskyj&rft.aufirst=KA&rft.date=2000-09-01&rft.volume=6&rft.issue=9&rft.spage=1048&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Salmonella typhimurium; Shigella flexneri; Salmonellosis; Shigellosis; Gastrointestinal tract; Nerve endings; Galanin; Diarrhea; Galanin receptors ER - TY - JOUR T1 - NAC-1 is a brain POZ/BTB protein that can prevent cocaine-induced sensitization in the rat. AN - 71761317; 10934270 AB - Levels of the mRNA NAC-1 are increased in the rat forebrain weeks after cocaine exposure. This long-term neuroadaptation occurs during the expression of behavioral sensitization, a model of psychostimulant-induced paranoia. NAC-1, the protein encoded by this cocaine-regulated mRNA, contains a Pox virus and zinc finger/bric-a-brac tramtrack broad complex (POZ/BTB) motif, which mediates interactions among several transcriptional regulators. The present studies demonstrate that NAC-1 acts as a transcription factor. NAC-1 was localized to the nucleus of neurons in the brain. Transfection of NAC-1 in cell culture repressed transcription of a reporter gene. NAC-1 was also able to affect the actions of other POZ/BTB proteins in mammalian two-hybrid studies; these interactions required the presence of the POZ/BTB domain. However, NAC-1 appears to be a unique POZ/BTB transcriptional regulator because it does not contain any zinc finger regions found in these other DNA-binding proteins. Adenoviral-mediated overexpression of NAC-1 protein in the rat nucleus accumbens prevented the development but not the expression of behavioral sensitization produced by repeated administration of cocaine. Thus, NAC-1 may modify the long-term behaviors of psychostimulant abuse by regulating gene transcription in the mammalian brain. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Mackler, S A AU - Korutla, L AU - Cha, X Y AU - Koebbe, M J AU - Fournier, K M AU - Bowers, M S AU - Kalivas, P W AD - Departments of Medicine and Psychiatry, Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania 19104, USA. smackler@mail.med.upenn.edu Y1 - 2000/08/15/ PY - 2000 DA - 2000 Aug 15 SP - 6210 EP - 6217 VL - 20 IS - 16 SN - 0270-6474, 0270-6474 KW - ABTB1 protein, human KW - 0 KW - Nacc1 protein, rat KW - Nerve Tissue Proteins KW - Repressor Proteins KW - Transcription Factors KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Nucleus Accumbens -- drug effects KW - Cocaine-Related Disorders -- physiopathology KW - Protein Structure, Tertiary -- physiology KW - Nucleus Accumbens -- metabolism KW - Nucleus Accumbens -- physiopathology KW - Cocaine-Related Disorders -- metabolism KW - Male KW - Binding Sites -- physiology KW - Transcription, Genetic -- physiology KW - Brain -- physiopathology KW - Brain -- drug effects KW - Repressor Proteins -- metabolism KW - Nerve Tissue Proteins -- metabolism KW - Cocaine -- toxicity KW - Brain -- metabolism KW - Nerve Tissue Proteins -- genetics KW - Repressor Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71761317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=NAC-1+is+a+brain+POZ%2FBTB+protein+that+can+prevent+cocaine-induced+sensitization+in+the+rat.&rft.au=Mackler%2C+S+A%3BKorutla%2C+L%3BCha%2C+X+Y%3BKoebbe%2C+M+J%3BFournier%2C+K+M%3BBowers%2C+M+S%3BKalivas%2C+P+W&rft.aulast=Mackler&rft.aufirst=S&rft.date=2000-08-15&rft.volume=20&rft.issue=16&rft.spage=6210&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-31 N1 - Date created - 2000-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment of an edentulous patient with a dry mouth. AN - 70549739; 12167886 AB - Dental health professionals are being asked to care for a growing number and range of medically compromised patients living with chronic health problems. Although tooth loss overall has declined in the United States, millions of persons, particularly those of more advanced age, still require treatment for the edentulous condition. Particular challenges are faced when this oral state is combined with a complex medical history. The primary learning objective for this case is to increase your general knowledge of and skills in the dental management of the complete denture patient with a dry mouth. JF - The journal of contemporary dental practice AU - Shay, K AD - VA Health Services of lower Michigan, USA. Ken.Shay@med.va.gov Y1 - 2000/08/15/ PY - 2000 DA - 2000 Aug 15 SP - 98 VL - 1 IS - 3 KW - Adhesives KW - 0 KW - Anti-Inflammatory Agents KW - Anti-Inflammatory Agents, Non-Steroidal KW - Antirheumatic Agents KW - Salicylates KW - salicylsalicylic acid KW - V9MO595C9I KW - Prednisone KW - VB0R961HZT KW - Methotrexate KW - YL5FZ2Y5U1 KW - Dentistry KW - Index Medicus KW - Prednisone -- pharmacology KW - Drug Interactions KW - Methotrexate -- pharmacology KW - Humans KW - Aged KW - Antirheumatic Agents -- pharmacology KW - Salicylates -- pharmacology KW - Patient Education as Topic KW - Denture, Complete KW - Denture Retention KW - Male KW - Anti-Inflammatory Agents -- pharmacology KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology KW - Arthritis, Rheumatoid -- complications KW - Xerostomia -- complications KW - Mouth, Edentulous -- therapy KW - Mouth, Edentulous -- complications KW - Dental Care for Chronically Ill UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70549739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+contemporary+dental+practice&rft.atitle=Treatment+of+an+edentulous+patient+with+a+dry+mouth.&rft.au=Shay%2C+K&rft.aulast=Shay&rft.aufirst=K&rft.date=2000-08-15&rft.volume=1&rft.issue=3&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=The+journal+of+contemporary+dental+practice&rft.issn=1526-3711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-08-21 N1 - Date created - 2002-08-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of cholera toxin on rat liver lysosome acidification. AN - 71264919; 10924342 AB - We have shown that cholera toxin and cAMP greatly increase both acidification rates of liver endosomes and the liver and endosome content of fluid-phase endocytosis probes. In this study lysosomes were purified from control and cholera toxin-treated livers that were pulsed with fluorescein conjugated dextran and chased overnight. Cholera toxin-treated livers weighed less, contained less protein and exhibited higher contents of lysosomal marker enzymes, consistent with the catabolic effects of this agent. By contrast to its effects on endosomes, cholera toxin had no consistent or significant effect on lysosome acidification rates, steady-state internal pH or potassium content, proton leak rates or fluorescein-dextran content. We conclude that cholera toxin and cAMP predominantly alter earlier steps of endocytosis but may also increase transfer of probes from lysosomes to bile. Copyright 2000 Academic Press. JF - Biochemical and biophysical research communications AU - Van Dyke, R W AU - Ervin, L L AU - Lewis, M R AU - Wang, X AD - Department of Medicine, University of Michigan Medical School and Veterans' Administration Hospital, Ann Arbor, Michigan, 48109-0682, USA. Y1 - 2000/08/11/ PY - 2000 DA - 2000 Aug 11 SP - 717 EP - 721 VL - 274 IS - 3 SN - 0006-291X, 0006-291X KW - Adjuvants, Immunologic KW - 0 KW - Cholera Toxin KW - 9012-63-9 KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Ion Transport -- drug effects KW - Cyclic AMP -- pharmacology KW - Endocytosis -- drug effects KW - Male KW - Liver -- ultrastructure KW - Liver -- drug effects KW - Cholera Toxin -- pharmacology KW - Liver -- metabolism KW - Lysosomes -- metabolism KW - Lysosomes -- drug effects KW - Adjuvants, Immunologic -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71264919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Effect+of+cholera+toxin+on+rat+liver+lysosome+acidification.&rft.au=Van+Dyke%2C+R+W%3BErvin%2C+L+L%3BLewis%2C+M+R%3BWang%2C+X&rft.aulast=Van+Dyke&rft.aufirst=R&rft.date=2000-08-11&rft.volume=274&rft.issue=3&rft.spage=717&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-15 N1 - Date created - 2000-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Elderly Norms for the Hopkins Verbal Learning Test-Revised AN - 85534596; 200113503 AB - The present study evaluates the effects of age, education, & gender in a representative sample of older adults & provides normative data for community-dwelling elderly. Age & gender had significant effects on HVLT-R performance. We provide age- & gender-adjusted normative data. Surprisingly, education level did not affect HVLT-R performance, indicating that education-adjusted norms are not necessary for this measure within this age range. We evaluated a subsample of subjects census-matched on age, education, & gender. These subjects did not differ in overall performance from our entire sample. Therefore, the normative data provided in this paper can be considered to be census-comparable for age, education, & gender. Adapted from the source document JF - The Clinical Neuropsychologist AU - Vanderploeg, Rodney D AU - Schinka, John A AU - Jones, Tatyana AU - Small, Brent J AU - Graves, Amy Borenstein AU - Mortimer, James A AD - Psychology Service, James A. Haley Veterans Hospital, Tampa, FL Rodney.Vanderploeg@med.va.gov Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 318 EP - 324 VL - 14 IS - 3 SN - 1385-4046, 1385-4046 KW - Elderly (21350) KW - Psychometric Analysis (69210) KW - Age Differences (01150) KW - Verbal Learning (93750) KW - Sex Differences (77850) KW - Academic Achievement (00070) KW - Test Validity and Reliability (88800) KW - article KW - 6910: psychometrics; psychometrics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85534596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Clinical+Neuropsychologist&rft.atitle=Elderly+Norms+for+the+Hopkins+Verbal+Learning+Test-Revised&rft.au=Vanderploeg%2C+Rodney+D%3BSchinka%2C+John+A%3BJones%2C+Tatyana%3BSmall%2C+Brent+J%3BGraves%2C+Amy+Borenstein%3BMortimer%2C+James+A&rft.aulast=Vanderploeg&rft.aufirst=Rodney&rft.date=2000-08-01&rft.volume=14&rft.issue=3&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=The+Clinical+Neuropsychologist&rft.issn=13854046&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CLNEEC N1 - SubjectsTermNotLitGenreText - Psychometric Analysis (69210); Verbal Learning (93750); Test Validity and Reliability (88800); Sex Differences (77850); Age Differences (01150); Elderly (21350); Academic Achievement (00070) ER - TY - JOUR T1 - Long-term follow-up of Barrett's high-grade dysplasia. AN - 85356663; pmid-10950031 AB - OBJECTIVE: The management of Barrett's high-grade dysplasia (HGD) remains controversial. The aims of this study were to evaluate prospectively the outcome of unifocal HGD (uHGD) in patients with Barrett's esophagus, and to determine demographic and endoscopic features predictive of progression to multifocal HGD (mHGD) and/or adenocarcinoma. METHODS: Consecutive Barrett's patients in whom uHGD was found at initial endoscopy or during surveillance underwent intensification of medical treatment and repeat endoscopy. The study endpoint was progression to mHGD or adenocarcinoma or HGD in conjunction with a dysplasia-associated lesion or mass (DALM). HGD diagnosis was confirmed by a second, blinded pathologist. RESULTS: A total of 15 Barrett's patients with uHGD met inclusion criteria and have been prospectively followed for a mean +/- SD of 36.8 +/- 23.2 months. All were white and male, with a mean age +/- SD of 61.4 +/- 14.9 yr. Barrett's length varied from 1 to 13 cm (mean, +/- SD, 6.8 +/- 4 cm). Overall, eight (53.3%) uHGD progressed: four of 15 (26.7%) to frank cancer between 17 and 35 months of follow-up, two of 15 (13.3%) to mHGD with DALM in conjunction with one or more foci of possible intramucosal cancer after 12-91 months of follow-up, one of 15 (6.7%) to mHGD with a focus of possible intramucosal cancer after 14 months, and one of 15 (6.7%) to mHGD after 29 months. Seven of 15 (46.7%) uHGD have regressed, five to no dysplasia and two to LGD, over the course of follow-up ranging from 24 to 73 months (mean +/- SD, 43.3 +/- 19.9). All three patients with short-segment Barrett's esophagus with uHGD regressed. Fisher's exact test revealed that Barrett's length > or =3 cm and presence of hiatal hernia approached significance (p < 0.08) in predicting uHGD progression to mHGD/DALM/cancer. However, use of the log-rank test to account for differences in length of follow-up show no significance for hiatal hernia or Barrett's length. CONCLUSIONS: Barrett's uHGD has a high risk for progressing to mHGD or cancer. Justification of an observational approach to uHGD should be discouraged. Markers of uHGD progression, as well as regression, are needed. JF - The American journal of gastroenterology AU - Weston, A P AU - Sharma, P AU - Topalovski, M AU - Richards, R AU - Cherian, R AU - Dixon, A AD - Veterans Administration Medical Center, Kansas City, Missouri 64128, USA. Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 1888 EP - 1893 VL - 95 IS - 8 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Prospective Studies KW - Single-Blind Method KW - Humans KW - Adult KW - Disease Progression KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Longitudinal Studies KW - Male KW - Adenocarcinoma -- pathology KW - Esophageal Neoplasms -- pathology KW - Esophagus -- pathology KW - Barrett Esophagus -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85356663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Long-term+follow-up+of+Barrett%27s+high-grade+dysplasia.&rft.au=Weston%2C+A+P%3BSharma%2C+P%3BTopalovski%2C+M%3BRichards%2C+R%3BCherian%2C+R%3BDixon%2C+A&rft.aulast=Weston&rft.aufirst=A&rft.date=2000-08-01&rft.volume=95&rft.issue=8&rft.spage=1888&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Gulf War illness research: separating the wheat from the chaff. AN - 72601651; 11262710 AB - Clinical research of veterans' illnesses from the neuropsychology and medical literature are reviewed. Some studies reveal no significant findings, while others indeed detect a higher incidence of clinical and laboratory abnormalities in veterans of Operations Desert Storm and Desert Shield. Neuropsychological deficits are negligible and more often associated with affective, than cognitive, disruption. Some explanations of the results are offered, as are recommendations regarding the utility of clinical research. JF - The Clinical neuropsychologist AU - Axelrod, B N AU - Milner, I B AD - John D. Dingell Department of Veterans Affairs Medical Center, Detroit, MI, USA. bradley.axelrod@med.va.gov Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 344 EP - 348 VL - 14 IS - 3 SN - 1385-4046, 1385-4046 KW - Index Medicus KW - Humans KW - Veterans -- psychology KW - Neuropsychological Tests KW - Cognition Disorders -- etiology KW - Cognition Disorders -- diagnosis KW - Persian Gulf Syndrome -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72601651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Clinical+neuropsychologist&rft.atitle=Gulf+War+illness+research%3A+separating+the+wheat+from+the+chaff.&rft.au=Axelrod%2C+B+N%3BMilner%2C+I+B&rft.aulast=Axelrod&rft.aufirst=B&rft.date=2000-08-01&rft.volume=14&rft.issue=3&rft.spage=344&rft.isbn=&rft.btitle=&rft.title=The+Clinical+neuropsychologist&rft.issn=13854046&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enteropathogenic Escherichia coli dephosphorylates and dissociates occludin from intestinal epithelial tight junctions. AN - 72562038; 11207587 AB - Enteropathogenic Escherichia coli (EPEC) increases tight junction permeability in part by phosphorylating the 20 kDa myosin light chain (MLC20) that induces cytoskeletal contraction. The impact of this enteric pathogen on specific tight junction (TJ) proteins has not been investigated. We examined the effect of EPEC infection on occludin localization and phosphorylation in intestinal epithelial cells. After infection by EPEC, a progressive shift of occludin from a primarily TJ-associated domain to an intracellular compartment occurred, as demonstrated by immunofluorescent staining. A reverse in the ratio of phosphorylated to dephosphorylated occludin accompanied this morphological change. Eradication of EPEC with gentamicin resulted in the normalization of occludin localization and phosphorylation. The serine/threonine phosphatase inhibitor, calyculin A, prevented these events. The EPEC-associated decrease in transepithelial electrical resistance, a measure of TJ barrier function, returned to baseline after gentamicin treatment. Non-pathogenic E. coli, K-12, did not induce these changes. Transformation of K-12 with the pathogenicity island of EPEC, however, conferred the phenotype of wild-type EPEC. Deletion of specific EPEC genes encoding proteins involved in EPEC type III secretion markedly attenuated these effects. These findings suggest that EPEC-induced alterations in occludin contribute to the pathophysiology associated with this infection. JF - Cellular microbiology AU - Simonovic, I AU - Rosenberg, J AU - Koutsouris, A AU - Hecht, G AD - Department of Medicine, University of Illinois and West Side Department of Veterans Administration Medical Center, Chicago, IL 60612, USA. Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 305 EP - 315 VL - 2 IS - 4 SN - 1462-5814, 1462-5814 KW - Anti-Bacterial Agents KW - 0 KW - Bacterial Proteins KW - Gentamicins KW - Membrane Proteins KW - OCLN protein, human KW - Occludin KW - Oxazoles KW - calyculin A KW - 7D07U14TK3 KW - Index Medicus KW - Immunoblotting KW - Transformation, Bacterial KW - Bacterial Proteins -- genetics KW - Humans KW - Anti-Bacterial Agents -- pharmacology KW - Tight Junctions -- drug effects KW - Gene Deletion KW - Virulence KW - Tumor Cells, Cultured KW - Oxazoles -- pharmacology KW - Phosphorylation KW - Time Factors KW - Fluorescent Antibody Technique KW - Gentamicins -- pharmacology KW - Tight Junctions -- metabolism KW - Membrane Proteins -- metabolism KW - Escherichia coli -- pathogenicity KW - Intestinal Mucosa -- microbiology KW - Intestinal Mucosa -- metabolism KW - Intestinal Mucosa -- drug effects KW - Escherichia coli -- genetics KW - Membrane Proteins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72562038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+microbiology&rft.atitle=Enteropathogenic+Escherichia+coli+dephosphorylates+and+dissociates+occludin+from+intestinal+epithelial+tight+junctions.&rft.au=Simonovic%2C+I%3BRosenberg%2C+J%3BKoutsouris%2C+A%3BHecht%2C+G&rft.aulast=Simonovic&rft.aufirst=I&rft.date=2000-08-01&rft.volume=2&rft.issue=4&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Cellular+microbiology&rft.issn=14625814&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-15 N1 - Date created - 2001-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Leukocytoclastic vasculitis due to etanercept. AN - 72202869; 10955351 AB - Recently etanercept, a soluble recombinant tumor necrosis factor receptor:Fc fusion protein, became available to treat patients with rheumatoid arthritis (RA). Among adverse reactions are cutaneous side effects, which occur in about 5% of patients. These have included mostly injection site reactions as well as urticarial reactions. We describe the first case of leukocytoclastic vasculitis associated with the use of etanercept in a patient with severe, deforming RA previously unresponsive to multiple therapies. Discontinuation of the drug led to complete resolution of the vasculitis. JF - The Journal of rheumatology AU - Galaria, N A AU - Werth, V P AU - Schumacher, H R AD - Department of Dermatology, Hospital of the University of Pennsylvania, and the Veterans Administration Hospital, Philadelphia, USA. Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 2041 EP - 2044 VL - 27 IS - 8 SN - 0315-162X, 0315-162X KW - Antirheumatic Agents KW - 0 KW - Immunoglobulin G KW - Receptors, Tumor Necrosis Factor KW - Recombinant Proteins KW - Etanercept KW - OP401G7OJC KW - Index Medicus KW - Fluorescent Antibody Technique, Direct KW - Humans KW - Middle Aged KW - Male KW - Vasculitis, Leukocytoclastic, Cutaneous -- chemically induced KW - Arthritis, Rheumatoid -- drug therapy KW - Immunoglobulin G -- adverse effects KW - Antirheumatic Agents -- adverse effects KW - Recombinant Proteins -- adverse effects KW - Vasculitis, Leukocytoclastic, Cutaneous -- pathology KW - Arthritis, Rheumatoid -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72202869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+rheumatology&rft.atitle=Leukocytoclastic+vasculitis+due+to+etanercept.&rft.au=Galaria%2C+N+A%3BWerth%2C+V+P%3BSchumacher%2C+H+R&rft.aulast=Galaria&rft.aufirst=N&rft.date=2000-08-01&rft.volume=27&rft.issue=8&rft.spage=2041&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+rheumatology&rft.issn=0315162X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-14 N1 - Date created - 2000-11-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sodium-sensitive hypertension is not associated with higher sympathetic nervous system activity in older hypertensive humans. AN - 71752768; 10950395 AB - The majority of older hypertensive humans are sodium sensitive and they are characterized by increased alpha-adrenergic responsiveness relative to their level of sympathetic nervous system (SNS) activity. To test the hypothesis that heightened SNS activity and/or increased alpha-adrenergic receptor responsiveness during sodium loading may play a role in the sodium-dependent increase in blood pressure in older sodium-sensitive hypertensives, we used compartmental analysis of [3H]norepinephrine (NE) kinetics to determine the release rate of NE into an extravascular compartment (NE2) as an index of systemic SNS activity and determined forearm blood flow responses to graded intrabrachial artery NE and angiotensin II (ANG II) infusions and platelet membrane alpha2-receptor properties in 24 older (age 64 +/- 7 years) hypertensive subjects. Subjects were studied at the end of 1 week of a low (20 mmol/day)- and again at the end of 1 week of a high (200 mmol/day)-sodium diet. Subjects were categorized as sodium sensitive (SS) if they had a > or = 5 mm Hg increase in mean arterial blood pressure (MABP) with dietary sodium loading (n = 16), or sodium-resistant (SR) if their MABP increased by < 5 mm Hg (n = 8). Neither dietary sodium intake nor sodium-sensitivity status significantly affected arterial plasma NE levels, NE2, or other NE kinetic parameters. Forearm blood flow responses to NE or to ANG II, and platelet alpha2-receptor properties were similar between the SS and SR groups. These results suggest that the sodium-dependent increase in MABP that characterizes SS hypertension among older humans is not because of an increase in systemic SNS activity or increased arterial adrenergic receptor responsiveness. JF - American journal of hypertension AU - Brown, M D AU - Hogikyan, R V AU - Dengel, D R AU - Supiano, M A AD - Department of Internal Medicine, University of Michigan Health System and GRECC, Ann Arbor Veterans Administration Health System, USA. mb166@umail.umd.edu Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 873 EP - 883 VL - 13 IS - 8 SN - 0895-7061, 0895-7061 KW - Sodium Chloride, Dietary KW - 0 KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Norepinephrine KW - X4W3ENH1CV KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - Age Factors KW - Norepinephrine -- blood KW - Humans KW - Blood Platelets -- enzymology KW - Adenylyl Cyclases -- metabolism KW - Middle Aged KW - Epinephrine -- blood KW - Regional Blood Flow KW - Male KW - Female KW - Sodium Chloride, Dietary -- adverse effects KW - Hypertension -- physiopathology KW - Sympathetic Nervous System -- physiopathology KW - Sodium Chloride, Dietary -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71752768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hypertension&rft.atitle=Sodium-sensitive+hypertension+is+not+associated+with+higher+sympathetic+nervous+system+activity+in+older+hypertensive+humans.&rft.au=Brown%2C+M+D%3BHogikyan%2C+R+V%3BDengel%2C+D+R%3BSupiano%2C+M+A&rft.aulast=Brown&rft.aufirst=M&rft.date=2000-08-01&rft.volume=13&rft.issue=8&rft.spage=873&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hypertension&rft.issn=08957061&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-02 N1 - Date created - 2001-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Is succinylcholine after pretreatment with d-tubocurarine and lidocaine contraindicated for outpatient anesthesia? AN - 71255751; 10910840 AB - Because succinylcholine has obvious advantages for facilitating endotracheal intubation in the ambulatory setting (e.g., low cost, fast onset, and no need for reversal of neuromuscular block), it is important to determine whether this muscle relaxant is indeed associated with an increased incidence of postoperative myalgias, compared with alternative but more expensive nondepolarizing muscle relaxants. We studied 119 outpatients undergoing endoscopic nasal sinus surgery or septoplasty. The anesthetic technique consisted of propofol/lidocaine for induction, followed by isoflurane/nitrous oxide/oxygen for maintenance. Oral tracheal intubation was performed by using a fiberscope. Patients were randomly assigned to one of two muscle relaxant groups. Group 1 patients received d-tubocurarine 3 mg followed by succinylcholine 1.5 mg/kg. Group 2 patients received mivacurium 0.2 mg/kg. After recovery from anesthesia, patients were asked whether they had any muscle pain and/or stiffness. Pain was categorized by location and quantified by using a verbal scale (from 0 to 10). Analgesic usage and myalgias limiting ambulation were recorded. After discharge from the ambulatory surgery unit, patients were contacted by telephone on Postoperative Day 1. If patients complained of myalgias, they were contacted by telephone on Days 2 and 3. Only one patient (in the mivacurium-treated group) reported myalgia as a limiting factor in ambulation or resumption of normal activity. There were no differences between groups with respect to the incidence (21% in the succinylcholine-treated group and 18% in the mivacurium-treated group), location, or severity of myalgia. In conclusion, succinylcholine (preceded by pretreatment with d-tubocurarine and lidocaine) is not associated with an increased incidence of myalgias, compared with mivacurium, when used to facilitate tracheal intubation in patients undergoing ambulatory nasal surgery. The results of this study show that the frequency of muscle pains after surgery in outpatients is approximately 20%, regardless of whether succinylcholine (after precurarization) or mivacurium is used to assist in insertion of the breathing tube. JF - Anesthesia and analgesia AU - Mikat-Stevens, M AU - Sukhani, R AU - Pappas, A L AU - Fluder, E AU - Kleinman, B AU - Stevens, R A AD - Department of Anesthesiology, Edward Hines Veterans Administration Hospital, Hines, USA. Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 312 EP - 316 VL - 91 IS - 2 SN - 0003-2999, 0003-2999 KW - Anesthetics, Local KW - 0 KW - Isoquinolines KW - Neuromuscular Depolarizing Agents KW - Neuromuscular Nondepolarizing Agents KW - mivacurium KW - 77D66S9Q93 KW - Lidocaine KW - 98PI200987 KW - Succinylcholine KW - J2R869A8YF KW - Tubocurarine KW - W9YXS298BM KW - Abridged Index Medicus KW - Index Medicus KW - Anesthesia Recovery Period KW - Humans KW - Intubation, Intratracheal KW - Adult KW - Surveys and Questionnaires KW - Isoquinolines -- administration & dosage KW - Paranasal Sinuses -- surgery KW - Male KW - Female KW - Lidocaine -- administration & dosage KW - Muscular Diseases -- drug therapy KW - Neuromuscular Depolarizing Agents -- adverse effects KW - Ambulatory Surgical Procedures KW - Succinylcholine -- administration & dosage KW - Neuromuscular Nondepolarizing Agents -- administration & dosage KW - Succinylcholine -- contraindications KW - Succinylcholine -- adverse effects KW - Neuromuscular Depolarizing Agents -- contraindications KW - Tubocurarine -- administration & dosage KW - Anesthetics, Local -- administration & dosage KW - Muscular Diseases -- chemically induced KW - Pain, Postoperative -- drug therapy KW - Neuromuscular Depolarizing Agents -- administration & dosage KW - Pain, Postoperative -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71255751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Is+succinylcholine+after+pretreatment+with+d-tubocurarine+and+lidocaine+contraindicated+for+outpatient+anesthesia%3F&rft.au=Mikat-Stevens%2C+M%3BSukhani%2C+R%3BPappas%2C+A+L%3BFluder%2C+E%3BKleinman%2C+B%3BStevens%2C+R+A&rft.aulast=Mikat-Stevens&rft.aufirst=M&rft.date=2000-08-01&rft.volume=91&rft.issue=2&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=00032999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-15 N1 - Date created - 2000-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Variable Absorption of Carbidopa Affects Both Peripheral and Central Levodopa Metabolism AN - 21195817; 11643636 AB - Carbidopa (CD), a competitive inhibitor of aromatic l-amino acid decarboxylase that does not cross the blood-brain barrier, is routinely administered with levodopa (LD) to patients with Parkinson disease (PD) to reduce the peripheral decarboxylation of LD to dopamine. Using a stable isotope-labeled form of LD, the authors examined in 9 PD patients the effects of variable CD absorption on peripheral and central LD metabolism. Subjects were administered orally 50 mg of CD followed in 1 hour by a slow bolus intravenous infusion of 150 mg stable isotope-labeled LD (ring 1',2',3',4',5',6'- super(13)C). Eight patients underwent a lumbar puncture 6 hours following the infusion. Blood and cerebrospinal fluid (CSF) samples were analyzed for labeled and unlabeled metabolites using a combination of high-performance liquid chromatography and mass spectrometry. When patients were divided into 'slow' and 'rapid' CD absorption groups, significantly greater peripheral LD decarboxylation (as measured by area under the curve [AUC]-labeled serum HVA) was noted in the poor absorbers (p = 0.05, Mann-Whitney U test). Elimination half-lives for serum LD did not differ between groups, suggesting a further capacity for decarboxylation inhibition in the 'rapid' absorbers. A significant correlation between AUC serum CD and percent-labeled HVA in CSF was found for all patients (R = 0.786, p = 0.02). 'Rapid' as compared to 'slow' CD absorbers had significantly more percent-labeled CSF HVA (60 vs. 49, p = 0.02, Mann-Whitney U test), indicating greater central-labeled DA production in the better CD absorbers. The data suggest that peripheral aromatic l-amino acid decarboxylase activity is not saturated at CD doses used in current practice. The authors believe that future studies to better examine a dose dependence of CD on peripheral LD decarboxylation and LD brain uptake are warranted. JF - Journal of Clinical Pharmacology AU - Durso, R AU - Evans, JE AU - Josephs, E AU - Szabo, G AU - Evans, B AU - Fernandez, H H AU - Browne, T R AD - Departments of Neurology, Boston Veterans Administration Med ical Center and Boston University School of Medicine, Boston, Massachu setts; Department of Neurology, Boston University School of Medicine/Boston VAMC, 150 South Huntington Avenue, Boston, MA 02130 Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 854 EP - 860 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 40 IS - 8 SN - 0091-2700, 0091-2700 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - High-performance liquid chromatography KW - Intravenous administration KW - Levodopa KW - Data processing KW - Blood-brain barrier KW - Parkinson's disease KW - Brain KW - Metabolites KW - Mass spectroscopy KW - Neurodegenerative diseases KW - Cerebrospinal fluid KW - Dopamine KW - Movement disorders KW - Aromatic-L-amino-acid decarboxylase KW - Decarboxylation KW - X 24310:Pharmaceuticals KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21195817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Pharmacology&rft.atitle=Variable+Absorption+of+Carbidopa+Affects+Both+Peripheral+and+Central+Levodopa+Metabolism&rft.au=Durso%2C+R%3BEvans%2C+JE%3BJosephs%2C+E%3BSzabo%2C+G%3BEvans%2C+B%3BFernandez%2C+H+H%3BBrowne%2C+T+R&rft.aulast=Durso&rft.aufirst=R&rft.date=2000-08-01&rft.volume=40&rft.issue=8&rft.spage=854&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Pharmacology&rft.issn=00912700&rft_id=info:doi/10.1177%2F009127000004000806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Levodopa; Intravenous administration; Data processing; Blood-brain barrier; Parkinson's disease; Brain; Metabolites; Mass spectroscopy; Neurodegenerative diseases; Cerebrospinal fluid; Movement disorders; Dopamine; Aromatic-L-amino-acid decarboxylase; Decarboxylation DO - http://dx.doi.org/10.1177/009127000004000806 ER - TY - JOUR T1 - Cancer Mortality Among the Highest Exposed US Atmospheric Nuclear Test Participants AN - 17761979; 4826837 AB - Of the estimated 205,000 military personnel who participated in the US atmospheric nuclear weapons testing program from 1945 to 1962, less than 1 % had ionizing radiation doses that met or exceeded the current federal occupational guideline for dose of 5 rem (roentgen equivalents in humans) in a 12-month period. The objective of this study was to determine whether veterans who received the highest gamma radiation doses (n = 1010) have experienced increased cancer mortality compared with a group of Navy veterans who received a minimal radiation dose as participants of HARDTACK I (n = 2870). Mortality from all causes of death (relative risk, 1.22; 95 % confidence interval, 1.04 to 1.44) and from all lymphopoietic cancers (relative risk, 3.72; 95 % confidence interval, 1.28 to 10.83) was significantly elevated among the 5-rem cohort compared with the Navy controls. The lack of statistically significant excesses in deaths from many of the known radiogenic cancers suggests that the observed excess mortality may be the result of many factors, of which radiation exposure was only one. JF - Journal of Occupational and Environmental Medicine AU - Dalager, NA AU - Kang, H K AU - Mahan, C M AD - Environmental Epidemiology Service, Veterans Health Administration, Department of Veterans Affairs, 1120 20th Street, NW, Suite 950, Washington, DC 20036, USA Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 798 EP - 805 VL - 42 IS - 8 SN - 1076-2752, 1076-2752 KW - man KW - Toxicology Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - ^a Radiation KW - Military KW - Occupational exposure KW - Mortality KW - Radioactive pollution KW - Cancer KW - Nuclear power plants KW - Ionizing radiation KW - Military personnel KW - H 8000:Radiation Safety/Electrical Safety KW - X 24210:Radiation & radioactive materials KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17761979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Cancer+Mortality+Among+the+Highest+Exposed+US+Atmospheric+Nuclear+Test+Participants&rft.au=Dalager%2C+NA%3BKang%2C+H+K%3BMahan%2C+C+M&rft.aulast=Dalager&rft.aufirst=NA&rft.date=2000-08-01&rft.volume=42&rft.issue=8&rft.spage=798&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Military; Occupational exposure; Ionizing radiation; Mortality; Cancer; Nuclear power plants; Military personnel; ^a Radiation; Radioactive pollution ER - TY - JOUR T1 - Glutamate-mediated neuroprotection against N-methyl-D-aspartate toxicity: A role for metabotropic glutamate receptors AN - 17703201; 4784698 AB - We studied N-methyl-D-aspartate-induced cell death in organotypic hippocampal slices from seven-day-old Wistar rat pups cultured for 12-14 days in a medium containing no added glutamate. Propidium iodide fluorescence intensity was used as an indicator of cell death measured with the help of confocal microscopy. Exposure of slices for 2 h to L-glutamate (1-500 mu M) prior to the N-methyl-D-aspartate challenge significantly reduced N-methyl-D-aspartate-induced cell death. Glutamate at 10 and 500 mu M concentrations was highly protective against N-methyl-D-aspartate-induced cell death, but was less protective at the 1 mu M concentration. The protection was not blocked by the Na super(+) channel blocker tetrodotoxin (1 mu M), the N-methyl-D-aspartate receptor antagonist D-2-amino-5-phosphonopentanoic acid (20 mu M) or the alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (20 mu M). 1S,3R-1-Aminocyclopentane-trans-1,3-dicarboxylic acid, an agonist at metabotropic glutamate receptor types 1, 2/3 and 5, was protective at 100 mu M but not at 50 mu M. In contrast, the ionotropic glutamate receptor agonist aspartate (250 mu M) facilitated N-methyl-D-aspartate toxicity. Treatment of slices with the protein kinase C inhibitor staurosporine (0.2 mu M) or antisense oligonucleotide (10 nM, 72 h) that selectively inhibits metabotropic glutamate receptor type 5 synthesis significantly reduced glutamate protection. These results suggest that ambient glutamate may reduce nerve cell susceptibility to injury caused by excessive N-methyl-D-aspartate receptor activation by acting at metabotropic glutamate receptors linked to protein kinase C. JF - Neuroscience AU - Adamchik, Y AU - Baskys, A AD - Long Beach VA Medical Center, 5901 E. Seventh Street, Long Beach, CA 90822, USA, andrius.baskys@med.va.gov Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 731 EP - 736 VL - 99 IS - 4 SN - 0306-4522, 0306-4522 KW - cell culture KW - rats KW - neuroprotection KW - glutamic acid receptors KW - protein kinase C KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Protein kinase C KW - Glutamic acid receptors (metabotropic) KW - N-Methyl-D-aspartic acid receptors KW - Aspartic acid KW - Hippocampus KW - Neuroprotection KW - NMDA KW - Cell death KW - Neurons KW - Neurotoxicity KW - Brain slice preparation KW - Glutamic acid KW - X 24240:Miscellaneous KW - N3 11070:Neurochemistry and cellular biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17703201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Glutamate-mediated+neuroprotection+against+N-methyl-D-aspartate+toxicity%3A+A+role+for+metabotropic+glutamate+receptors&rft.au=Adamchik%2C+Y%3BBaskys%2C+A&rft.aulast=Adamchik&rft.aufirst=Y&rft.date=2000-08-01&rft.volume=99&rft.issue=4&rft.spage=731&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cell death; Neurotoxicity; NMDA; Hippocampus; Glutamic acid; Aspartic acid; Neurons; N-Methyl-D-aspartic acid receptors; Glutamic acid receptors (metabotropic); Protein kinase C; Neuroprotection; Brain slice preparation ER - TY - JOUR T1 - Hypothermia and thermoregulatory derangements induced by valproic acid. AN - 71248989; 10891933 JF - Neurology AU - Zachariah, S B AU - Zachariah, A AU - Ananda, R AU - Stewart, J T AD - Neurology Service, Bay Pines VA Medical Center, University of South Florida College of Medicine, Bay Pines, FL 33744, USA. sally.zachariah@med.va.gov Y1 - 2000/07/12/ PY - 2000 DA - 2000 Jul 12 SP - 150 EP - 151 VL - 55 IS - 1 SN - 0028-3878, 0028-3878 KW - Anticonvulsants KW - 0 KW - Valproic Acid KW - 614OI1Z5WI KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Body Temperature Regulation -- drug effects KW - Hypothermia -- physiopathology KW - Body Temperature Regulation -- physiology KW - Hypothermia -- chemically induced KW - Anticonvulsants -- adverse effects KW - Valproic Acid -- adverse effects KW - Anticonvulsants -- administration & dosage KW - Valproic Acid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71248989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Hypothermia+and+thermoregulatory+derangements+induced+by+valproic+acid.&rft.au=Zachariah%2C+S+B%3BZachariah%2C+A%3BAnanda%2C+R%3BStewart%2C+J+T&rft.aulast=Zachariah&rft.aufirst=S&rft.date=2000-07-12&rft.volume=55&rft.issue=1&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-07 N1 - Date created - 2000-08-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Neurology. 2001 Jan 9;56(1):139 [11148261] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Semantic Capacities of the Right Hemisphere as Seen in Two Cases of Pure Word Blindness AN - 85526984; 200011435 AB - Patients with pure alexia (N = 2) were studied with tachistoscopically presented stimuli to examine factors influencing their ability to distinguish words from nonwords & to derive semantic information of exposures too brief for explicit letter identification. Both patients had profound right hemianopia & computerized tomography (CT) evidence of splenial destruction. Both patients were successful in making word/nonword decisions for high-frequency, but not low-frequency, words. They could judge semantic class membership reliably for such common categories as animals & vegetables, but not for arbitrarily selected categories, eg, office-related items. Judgments about the gender of people's names & place vs person name distinctions were made with high reliability. Results are interpreted as evidence for limited word recognition & semantic-processing capacity in the right hemisphere. 4 Tables, 45 References. Adapted from the source document JF - Journal of Psycholinguistic Research AU - Goodglass, Harold AU - Lindfield, Kimberly C AU - Alexander, Michael P AD - Aphasia Research Center, Dept Veterans Affairs Medical Center, Boston, MA goodglass@boston.va.gov Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 399 EP - 422 VL - 29 IS - 4 SN - 0090-6905, 0090-6905 KW - Cerebral Dominance (11500) KW - Aphasia (03400) KW - Nonsense Words (58350) KW - Word Recognition (98200) KW - Semantic Processing (76760) KW - article KW - 4014: psycholinguistics; semantic processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85526984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psycholinguistic+Research&rft.atitle=Semantic+Capacities+of+the+Right+Hemisphere+as+Seen+in+Two+Cases+of+Pure+Word+Blindness&rft.au=Goodglass%2C+Harold%3BLindfield%2C+Kimberly+C%3BAlexander%2C+Michael+P&rft.aulast=Goodglass&rft.aufirst=Harold&rft.date=2000-07-01&rft.volume=29&rft.issue=4&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psycholinguistic+Research&rft.issn=00906905&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JPLRB7 N1 - SubjectsTermNotLitGenreText - Semantic Processing (76760); Aphasia (03400); Cerebral Dominance (11500); Word Recognition (98200); Nonsense Words (58350) ER - TY - JOUR T1 - Unexpected neurotoxicity of etoposide phosphate administered in combination with other chemotherapeutic agents after blood-brain barrier modification to enhance delivery, using propofol for general anesthesia, in a rat model. AN - 85279515; pmid-10917363 AB - OBJECTIVE: Osmotic blood-brain barrier disruption (BBBD) increases brain and brain tumor delivery of chemotherapeutic agents, which results in increased efficacy against brain tumors. We previously noted that the use of propofol anesthesia for BBBD increased the percentage of successful disruptions, resulting in delivery of increased amounts of chemotherapeutic drugs. This study evaluated the neurotoxicity of combination chemotherapeutic administration with this enhanced delivery system. METHODS: Osmotic BBBD was performed in Long-Evans rats with isoflurane (n = 11) or propofol (n = 90) anesthesia. Carboplatin and/or melphalan, methotrexate, or etoposide phosphate was administered intra-arterially (IA) after BBBD using propofol anesthesia. Animals were assessed for systemic and neurological toxicity. Animals were killed for neuropathological evaluation 30 days after treatment. RESULTS: With propofol or isoflurane anesthesia, BBBD alone produced no systemic or neurological toxicity. Single agents were relatively non-neurotoxic when administered IA with BBBD, as were the combinations of carboplatin or melphalan with methotrexate. Etoposide phosphate in combination with any other agent was observed to be highly neurotoxic if both agents were administered after BBBD. Administration of etoposide phosphate before BBBD completely eliminated neurotoxicity, although acute pulmonary toxicity occurred with any combination of etoposide phosphate and methotrexate, regardless of the timing of administration. CONCLUSION: Neurotoxicity was significantly increased for etoposide phosphate combination groups, particularly when both drugs were administered IA after BBBD. This increase in neurotoxicity may reflect on increase in drug delivery observed with propofol anesthesia. The neurotoxicity of IA administered etoposide phosphate with BBBD and propofol anesthesia could be minimized by administering etoposide phosphate IA before BBBD and administering carboplatin or melphalan IA after BBBD. JF - Neurosurgery AU - Fortin, D AU - McCormick, C I AU - Remsen, L G AU - Nixon, R AU - Neuwelt, E A AD - Department of Neurology, Oregon Health Sciences University, and Veterans Administration Medical Center, Portland, USA. PY - 2000 SP - 199 EP - 207 VL - 47 IS - 1 SN - 0148-396X, 0148-396X KW - Rats KW - Organophosphorus Compounds KW - Rats, Long-Evans KW - Support, U.S. Gov't, P.H.S. KW - Neurotoxicity Syndromes KW - Antineoplastic Agents KW - Antineoplastic Combined Chemotherapy Protocols KW - Animal KW - Support, U.S. Gov't, Non-P.H.S. KW - Etoposide KW - Female KW - Blood-Brain Barrier KW - Anesthetics, Intravenous KW - Anesthesia, General KW - Disease Models, Animal KW - Propofol UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85279515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurosurgery&rft.atitle=Unexpected+neurotoxicity+of+etoposide+phosphate+administered+in+combination+with+other+chemotherapeutic+agents+after+blood-brain+barrier+modification+to+enhance+delivery%2C+using+propofol+for+general+anesthesia%2C+in+a+rat+model.&rft.au=Fortin%2C+D%3BMcCormick%2C+C+I%3BRemsen%2C+L+G%3BNixon%2C+R%3BNeuwelt%2C+E+A&rft.aulast=Fortin&rft.aufirst=D&rft.date=2000-07-01&rft.volume=47&rft.issue=1&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Neurosurgery&rft.issn=0148396X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Issues of fatherhood and recovery for VA substance abuse patients. AN - 72382849; 11061686 AB - Drug-addicted fathers bring to treatment many uncertainties about their relevance to their children. Whether they are in contact with their children or not, they often believe their children are better off without contact with them. In working with these fathers, the authors have observed these men raising a number of issues concerning the father role. These include having no concept of what a father should be, confusing the roles of manhood and fatherhood, feeling inadequate as a provider, and not knowing how to reconnect with children they have not seen, particularly daughters. The fathers also have to learn to deal with their own guilt concerning their abandonment of their children. Suggestions for interventions with the fathers are given and include offering a workshop for fathers where they are shown visual images of positive fathering and can discuss their own parenting experiences. JF - Journal of psychoactive drugs AU - Arenas, M L AU - Greif, G L AD - Special Populations Treatment Program, Baltimore Veterans Administration Medical Center, Maryland 21201, USA. PY - 2000 SP - 339 EP - 341 VL - 32 IS - 3 SN - 0279-1072, 0279-1072 KW - Index Medicus KW - United States KW - Humans KW - Child KW - Female KW - Parenting KW - United States Department of Veterans Affairs KW - Substance-Related Disorders -- rehabilitation KW - Fathers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72382849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=Issues+of+fatherhood+and+recovery+for+VA+substance+abuse+patients.&rft.au=Arenas%2C+M+L%3BGreif%2C+G+L&rft.aulast=Arenas&rft.aufirst=M&rft.date=2000-07-01&rft.volume=32&rft.issue=3&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-15 N1 - Date created - 2001-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gastrin-releasing peptide is a mitogen and a morphogen in murine colon cancer. AN - 71733539; 10939592 AB - Little is known about the factors involved in regulating the appearance, or differentiation, of solid tumors including those arising from the colon. We herein demonstrate that the mitogen gastrin-releasing peptide (GRP) is a morphogen, critically important in regulating the differentiation of murine colon cancer. Although epithelial cells lining the mouse colon do not normally express GRP and its receptor (GRP-R), both are aberrantly expressed by all better differentiated cancers in wild-type C57BL/6J mice treated with the carcinogen azoxymethane. Whereas small tumors in both wild-type and GRP-R-deficient (i.e., GRP-R-/-) mice are histologically similar, larger tumors become better differentiated in the former but degenerate into more poorly differentiated mucinous adenocarcinomas in the latter. This alteration in phenotype is attributable to GRP increasing focal adhesion kinase expression in GRP-R-expressing tumors. Consistent with GRP acting as a mitogen, GRP/GRP-R coexpressing tumors in wild-type animals also contain more proliferating cells than those occurring in GRP-R-/- mice. Yet tumors are similarly sized in animals of either genotype receiving azoxymethane for identical times, a finding attributable to the significantly higher number of apoptotic cells detected in GRP/GRP-R coexpressing cancers. Thus, these findings indicate that although GRP is a mitogen, aberrant expression does not result in increased tumor growth. Rather, the mitogenic properties of GRP are subordinate to it acting as a morphogen, where it and its receptor are critically involved in regulating colon cancer histological progression by promoting a well-differentiated phenotype. JF - Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research AU - Carroll, R E AU - Matkowskyj, K A AU - Tretiakova, M S AU - Battey, J F AU - Benya, R V AD - Department of Medicine, University of Illinois at Chicago, and Chicago Veterans Administration Medical Center, 60612, USA. Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 385 EP - 393 VL - 11 IS - 7 SN - 1044-9523, 1044-9523 KW - Carcinogens KW - 0 KW - Mitogens KW - Receptors, Bombesin KW - Gastrin-Releasing Peptide KW - 80043-53-4 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Focal Adhesion Kinase 1 KW - EC 2.7.10.2 KW - Focal Adhesion Protein-Tyrosine Kinases KW - Proto-Oncogene Proteins pp60(c-src) KW - Ptk2 protein, mouse KW - Azoxymethane KW - MO0N1J0SEN KW - Index Medicus KW - Animals KW - Carcinogens -- pharmacology KW - Apoptosis KW - Proto-Oncogene Proteins pp60(c-src) -- metabolism KW - Azoxymethane -- pharmacology KW - Mice KW - Protein-Tyrosine Kinases -- metabolism KW - Mice, Knockout KW - Epithelial Cells -- metabolism KW - Mice, Inbred C57BL KW - Receptors, Bombesin -- metabolism KW - Receptors, Bombesin -- immunology KW - Cell Division KW - Adenocarcinoma -- metabolism KW - Gastrin-Releasing Peptide -- metabolism KW - Adenocarcinoma -- chemically induced KW - Cell Differentiation KW - Colonic Neoplasms -- metabolism KW - Gastrin-Releasing Peptide -- immunology KW - Colonic Neoplasms -- pathology KW - Colonic Neoplasms -- chemically induced KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71733539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+growth+%26+differentiation+%3A+the+molecular+biology+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Gastrin-releasing+peptide+is+a+mitogen+and+a+morphogen+in+murine+colon+cancer.&rft.au=Carroll%2C+R+E%3BMatkowskyj%2C+K+A%3BTretiakova%2C+M+S%3BBattey%2C+J+F%3BBenya%2C+R+V&rft.aulast=Carroll&rft.aufirst=R&rft.date=2000-07-01&rft.volume=11&rft.issue=7&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Cell+growth+%26+differentiation+%3A+the+molecular+biology+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10449523&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bone marrow granulomas possibly associated with amiodarone. AN - 71231498; 10907978 AB - Amiodarone is a class III antiarrhythmic agent that is effective in treating different types of cardiac dysrhythmias. It was approved only for treatment of life-threatening ventricular dysrhythmias refractory to other therapy; however, its use for atrial dysrhythmias such as atrial fibrillation is well accepted. Adverse effects associated with amiodarone include pulmonary, hepatic, thyroid, ocular, and neurologic toxicities. Our patient experienced intermittent fever, night sweats, and fatigue while taking the drug for treatment of atrial fibrillation. Bone marrow biopsy showed granuloma formation after 17 months of therapy with amiodarone. Amiodarone was discontinued due to significant hypotension and shortness of breath. To our knowledge, this is the third case report of granuloma formation in bone marrow possibly associated with this agent. JF - Pharmacotherapy AU - Yamreudeewong, W AU - McIntyre, W W AU - Sun, T J AU - Ranelli, P L AD - School of Pharmacy, University of Wyoming, Cheyenne Veterans Administration Medical Center, 82001, USA. Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 855 EP - 859 VL - 20 IS - 7 SN - 0277-0008, 0277-0008 KW - Anti-Arrhythmia Agents KW - 0 KW - Amiodarone KW - N3RQ532IUT KW - Index Medicus KW - Bone Marrow -- pathology KW - Atrial Fibrillation -- complications KW - Humans KW - Atrial Fibrillation -- drug therapy KW - Middle Aged KW - Male KW - Granuloma -- chemically induced KW - Bone Marrow Diseases -- pathology KW - Granuloma -- pathology KW - Bone Marrow Diseases -- chemically induced KW - Amiodarone -- therapeutic use KW - Amiodarone -- adverse effects KW - Anti-Arrhythmia Agents -- adverse effects KW - Anti-Arrhythmia Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71231498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Bone+marrow+granulomas+possibly+associated+with+amiodarone.&rft.au=Yamreudeewong%2C+W%3BMcIntyre%2C+W+W%3BSun%2C+T+J%3BRanelli%2C+P+L&rft.aulast=Yamreudeewong&rft.aufirst=W&rft.date=2000-07-01&rft.volume=20&rft.issue=7&rft.spage=855&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antibacterial effect of telithromycin (HMR 3647) and comparative antibiotics against intracellular Legionella pneumophila AN - 17680130; 4751341 AB - The activity of the ketolide telithromycin (HMR 3647) against intracellular Legionella pneumophila strain L-1033 was compared with the activities of erythromycin and levofloxacin. To assay intracellular antibacterial activity, human monocytes were allowed to adhere to wells in 24-well tissue culture plates and were then exposed to L. pneumophila cells for 1 h to allow phagocytosis to occur. Antibiotics were added to the wells after removal of unphagocytosed bacteria. Quantitative bacterial cell counts were made from lysed monocytes at 0, 24, 48, 72 and 96 h. The antibacterial effects of antibiotics against intracellular L. pneumophila L-1033 were concentration and time dependent; at 10 x MIC the activity of telithromycin was greater than that of erythromycin and was less than that of levofloxacin (P < 0.01); telithromycin-rifampicin combinations showed no synergy or interference; and removal of telithromycin from assays at 24 h did not affect its intracellular antibacterial activity. In conclusion, the ketolide telithromycin has excellent activity against intracellular L. pneumophila strain L-1033 and should be evaluated for therapy of legionnaires' disease. JF - Journal of Antimicrobial Chemotherapy AU - Baltch, AL AU - Smith, R P AU - Ritz, W J AU - Franke, MA AU - Michelsen, P B AD - Infectious Disease Section, Stratton VA Medical Center and Albany Medical College, Albany, NY 12208, USA, baltch.aldona_@albany.va.gov Y1 - 2000/07// PY - 2000 DA - Jul 2000 SP - 51 EP - 55 VL - 46 IS - 1 SN - 0305-7453, 0305-7453 KW - telithromycin KW - Microbiology Abstracts B: Bacteriology KW - Legionella pneumophila KW - levofloxacin KW - Phagocytosis KW - Erythromycin KW - Legionnaire's disease KW - J 02786:Macrolide antibiotics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17680130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Antibacterial+effect+of+telithromycin+%28HMR+3647%29+and+comparative+antibiotics+against+intracellular+Legionella+pneumophila&rft.au=Baltch%2C+AL%3BSmith%2C+R+P%3BRitz%2C+W+J%3BFranke%2C+MA%3BMichelsen%2C+P+B&rft.aulast=Baltch&rft.aufirst=AL&rft.date=2000-07-01&rft.volume=46&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Legionella pneumophila; Erythromycin; levofloxacin; Phagocytosis; Legionnaire's disease ER - TY - JOUR T1 - Sexuality in persons with lower extremity amputations. AN - 85347505; pmid-10894204 AB - PURPOSE: There is a paucity of information regarding sexual functioning in persons with lower extremity amputations. The purpose of this study was to describe sexual and psychological functioning and health status in persons with lower extremity amputation. METHODS: Self-report surveys assessed sexual functioning (Derogatis Inventory), depression (Beck Depression Inventory, anxiety (State-Trait Anxiety Inventory), and health status (Health Status Questionnaire) in a convenience sample of 30 men with lower extremity amputations. Mean age of the participants was 57 years (range 32-79). Mean duration since amputation was 23 months (range 3-634 months). Twenty one subjects (70%) had trans-tibial and seven subjects (23%) had trans-femoral amputations. RESULTS: A majority of subjects were experiencing problems in several domains of sexual functioning. Fifty three percent (n = 16) of the subjects were engaged in sexual intercourse or oral sex at least once a month. Twenty seven percent (n = 8) were masturbating at least once a month. Nineteen subjects (63%) reported orgasmic problems and 67% were experiencing erectile difficulties. Despite these problems, interest in sex was high in over 90% of the subjects. There was no evidence of increased prevalence of depression or anxiety in these subjects when compared to other outpatient adult populations. CONCLUSIONS: Sexual problems were common in the subjects studied. Despite these problems, interest in sex remained high. Few investigations have been directed toward identifying the psychological and social factors that may contribute to these problems and more research with a larger population is needed in this area. JF - Disability and rehabilitation AU - Bodenheimer, C AU - Kerrigan, A J AU - Garber, S L AU - Monga, T N AD - Houston VAMC, TX 77030, USA. Bodenheimer,Carol_F+@Houston.VA.gov Y1 - 2000/06/15/ PY - 2000 DA - 2000 Jun 15 SP - 409 EP - 415 VL - 22 IS - 9 SN - 0963-8288, 0963-8288 KW - Index Medicus KW - National Library of Medicine KW - Age Factors KW - Humans KW - Health Status KW - Phantom Limb -- psychology KW - Aged KW - Texas KW - Pilot Projects KW - Sexual Behavior KW - Adaptation, Psychological KW - Adult KW - Middle Aged KW - Artificial Limbs -- psychology KW - Male KW - Female KW - Statistics, Nonparametric KW - Amputees -- rehabilitation KW - Sexuality KW - Amputees -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85347505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Disability+and+rehabilitation&rft.atitle=Sexuality+in+persons+with+lower+extremity+amputations.&rft.au=Bodenheimer%2C+C%3BKerrigan%2C+A+J%3BGarber%2C+S+L%3BMonga%2C+T+N&rft.aulast=Bodenheimer&rft.aufirst=C&rft.date=2000-06-15&rft.volume=22&rft.issue=9&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Disability+and+rehabilitation&rft.issn=09638288&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Recognition of dichotic digits under pre-cued and post-cued response conditions in young and elderly listeners. AN - 85344564; pmid-10905448 AB - Dichotic listening was evaluated in pre-cued and post-cued response conditions using a hierarchical set of one-, two- and three-pair dichotic digit materials. Thirty young adults (mean age 29.1 years) with normal hearing, and 30 older adults in the 60-79-year age range (mean age 68.7 years) with mild-to-moderate sensorineural hearing loss were evaluated. Several patterns of performance were observed. First, recognition performance in the pre-cued condition was better than recognition performance in the post-cued condition for one-, two- and three-pair digits for both age groups. Second, there was a right ear advantage in pre- and post-cued response conditions for both age groups. In the pre-cued condition, the right ear advantage was small owing to ceiling effects associated with ease of the listening task. In the post-cued condition, recognition performance decreased as a function of age, and left ear scores decreased faster than right ear scores, resulting in a larger right ear advantage in the 60-79-year group. Third, as the complexity of the listening task increased from easy (one-pair) to difficult (three-pairs), there was a corresponding decrease in recognition performance for both age groups. The increase in the difference in performance on easy and difficult tasks became larger as a function of age. JF - British journal of audiology AU - Strouse, A AU - Wilson, R H AU - Brush, N AD - Veteran Affairs Medical Center Mountain Home, Tennessee 37684, USA. anne.strouse@med.va.gov Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 141 EP - 151 VL - 34 IS - 3 SN - 0300-5364, 0300-5364 KW - Index Medicus KW - National Library of Medicine KW - Severity of Illness Index KW - Age Factors KW - Humans KW - Adult KW - Aging KW - Aged KW - Middle Aged KW - Hearing Loss, Sensorineural -- diagnosis KW - Speech Perception -- physiology KW - Mental Recall -- physiology KW - Cues KW - Dichotic Listening Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85344564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+audiology&rft.atitle=Recognition+of+dichotic+digits+under+pre-cued+and+post-cued+response+conditions+in+young+and+elderly+listeners.&rft.au=Strouse%2C+A%3BWilson%2C+R+H%3BBrush%2C+N&rft.aulast=Strouse&rft.aufirst=A&rft.date=2000-06-01&rft.volume=34&rft.issue=3&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=British+journal+of+audiology&rft.issn=03005364&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Nonsteroidal anti-inflammatory drugs in the elderly. AN - 72610433; 11706458 AB - Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in the elderly for the treatment of fever, pain, pain associated with inflammation in rheumatoid arthritis and osteoarthritis, neuromuscular disorders, headache, and musculoskeletal conditions. Each year in the United States, people spend 5 to 10 billion dollars to purchase prescription and over-the-counter NSAIDs. Gastrointestinal side effects such as ulcers and bleeding are the most prevalent and life-threatening problems associated with NSAIDs. Specifically in the elderly, NSAIDs have become a leading cause of hospitalization and may increase the risk of death from ulceration more than 4-fold. NSAIDs and the new class of cyclo-oxygenase-2 selective NSAIDs continue as drugs of choice for analgesia and anti-inflammatory effects. Physiological changes of aging worsen the side-effect profile of NSAIDs in the elderly. These side effects, when added to the increased potential for drug interactions, lead to a much greater risk for adverse outcomes when NSAIDs are used in the elderly patient. The similarities and differences in the NSAID agents warrant review in light of the newer drugs--celecoxib and rofecoxib--with their expected improvement in gastrointestinal side effects. This article reviews current information about using NSAIDs in elderly persons. JF - Pain management nursing : official journal of the American Society of Pain Management Nurses AU - Buffum, M AU - Buffum, J C AD - Nursing Service for Research, VA Medical Center, School of Nursing, School of Pharmacy, University of California, San Francisco, CA, USA. Martha.Buffum@med.va.gov Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 40 EP - 50 VL - 1 IS - 2 SN - 1524-9042, 1524-9042 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase Inhibitors KW - Lactones KW - Pyrazoles KW - Sulfonamides KW - Sulfones KW - rofecoxib KW - 0QTW8Z7MCR KW - Celecoxib KW - JCX84Q7J1L KW - Index Medicus KW - Nursing KW - Lactones -- adverse effects KW - Patient Education as Topic KW - Age Factors KW - Sulfonamides -- adverse effects KW - Lactones -- therapeutic use KW - Sulfonamides -- pharmacology KW - Nursing Care KW - Humans KW - Aged KW - Decision Making KW - Sulfonamides -- therapeutic use KW - Lactones -- pharmacology KW - Cyclooxygenase Inhibitors -- therapeutic use KW - Cyclooxygenase Inhibitors -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Cyclooxygenase Inhibitors -- pharmacology KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72610433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain+management+nursing+%3A+official+journal+of+the+American+Society+of+Pain+Management+Nurses&rft.atitle=Nonsteroidal+anti-inflammatory+drugs+in+the+elderly.&rft.au=Buffum%2C+M%3BBuffum%2C+J+C&rft.aulast=Buffum&rft.aufirst=M&rft.date=2000-06-01&rft.volume=1&rft.issue=2&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Pain+management+nursing+%3A+official+journal+of+the+American+Society+of+Pain+Management+Nurses&rft.issn=15249042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-10 N1 - Date created - 2001-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Detox in the ED: taking urgent action. AN - 72597904; 11503240 JF - JAAPA : official journal of the American Academy of Physician Assistants AU - Kuszmar, T J AU - Bell, L AU - Scholz, D M AD - Veterans Administration Maryland Health Care System, Primary Care Manager Domiciliary, Perry Point, USA. Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 43 EP - 4, 47-8, 52-4 VL - 13 IS - 6 SN - 1547-1896, 1547-1896 KW - Health technology assessment KW - Humans KW - Opioid-Related Disorders -- therapy KW - Alcohol-Related Disorders -- therapy KW - Clinical Protocols KW - Substance-Related Disorders -- therapy KW - Emergency Service, Hospital UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72597904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAAPA+%3A+official+journal+of+the+American+Academy+of+Physician+Assistants&rft.atitle=Detox+in+the+ED%3A+taking+urgent+action.&rft.au=Kuszmar%2C+T+J%3BBell%2C+L%3BScholz%2C+D+M&rft.aulast=Kuszmar&rft.aufirst=T&rft.date=2000-06-01&rft.volume=13&rft.issue=6&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=JAAPA+%3A+official+journal+of+the+American+Academy+of+Physician+Assistants&rft.issn=15471896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-11-01 N1 - Date created - 2001-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Investigating patient experiences after a formulary change. AN - 71224117; 10876747 JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Jean, C D AU - Triplett, J W AD - Department of Veterans Affairs Medical Center, Miami, FL 33125, USA. jean.carmela_d@miami.va.gov Y1 - 2000/06/01/ PY - 2000 DA - 2000 Jun 01 SP - 1052 EP - 1054 VL - 57 IS - 11 SN - 1079-2082, 1079-2082 KW - Anti-Allergic Agents KW - 0 KW - Loratadine KW - 7AJO3BO7QN KW - Cetirizine KW - YO7261ME24 KW - Index Medicus KW - Patient Satisfaction KW - Humans KW - Anti-Allergic Agents -- therapeutic use KW - Loratadine -- therapeutic use KW - Loratadine -- adverse effects KW - Cetirizine -- therapeutic use KW - Cetirizine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71224117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Investigating+patient+experiences+after+a+formulary+change.&rft.au=Jean%2C+C+D%3BTriplett%2C+J+W&rft.aulast=Jean&rft.aufirst=C&rft.date=2000-06-01&rft.volume=57&rft.issue=11&rft.spage=1052&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-19 N1 - Date created - 2000-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interaction between warfarin and trazodone. AN - 71191391; 10860134 AB - It is well known that there are many drug interactions involving warfarin. However, few data have been supplied to guide clinicians concerning the interaction between trazodone and warfarin. Three clinically significant cases of suspected trazodone and warfarin interactions were identified in a retrospective chart review based on changes in the prothrombin time (PT) and international normalized ratio (INR) that were not explained by other factors. In each of the cases, the INR changed by > or = 1.0 after the initiation or discontinuation of trazodone. In the patients who started trazodone, a subsequent decrease in the PT and INR resulted; conversely, the PT and INR increased in the patient who stopped trazodone therapy. Although none of the patients experienced adverse effects due to the marked changes in PT and INR, the warfarin dosages had to be adjusted accordingly on initiation and discontinuation of trazodone. These cases show that there is a potentially clinically significant interaction between trazodone and warfarin. The time to onset of the interaction is variable; the mechanism behind it is not known, but it may involve substrate or protein-binding competition. The use of trazodone on an as-needed basis for sleep is strongly discouraged in patients who are receiving warfarin, due to the difficulty of achieving a therapeutic PT and INR. Until more is known, patients and clinicians should be educated about this potential interaction and monitor for changes in the anticoagulant effects when trazodone is initiated or stopped. JF - The Annals of pharmacotherapy AU - Small, N L AU - Giamonna, K A AD - Department of Pharmacy, Central Texas Veterans Healthcare System, Temple 76504, USA. nancy.small@med.va.gov Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 734 EP - 736 VL - 34 IS - 6 SN - 1060-0280, 1060-0280 KW - Anti-Anxiety Agents KW - 0 KW - Anticoagulants KW - Warfarin KW - 5Q7ZVV76EI KW - Trazodone KW - YBK48BXK30 KW - Index Medicus KW - Drug Interactions KW - Aged, 80 and over KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Anticoagulants -- pharmacokinetics KW - Warfarin -- pharmacokinetics KW - International Normalized Ratio KW - Anti-Anxiety Agents -- pharmacokinetics KW - Trazodone -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71191391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Interaction+between+warfarin+and+trazodone.&rft.au=Small%2C+N+L%3BGiamonna%2C+K+A&rft.aulast=Small&rft.aufirst=N&rft.date=2000-06-01&rft.volume=34&rft.issue=6&rft.spage=734&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-18 N1 - Date created - 2000-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuropsychiatric symptoms associated with hepatitis C and interferon alpha: A review. AN - 71149231; 10831463 AB - Neuropsychiatric symptoms are commonly associated with chronic hepatitis C virus infection, its sequelae, and its treatment. In particular, interferon, a primary component of treatment for chronic hepatitis C, has been strongly associated with depressive symptoms. This review summarizes current knowledge about the etiology, course, and treatment of neuropsychiatric problems associated with hepatitis C and interferon alpha (IFN-alpha) treatment. Studies were identified by computerized searches, and further references were obtained from bibliographies of the reviewed articles. Chronic infection with the hepatitis C virus is a common and growing problem, often affecting persons with psychiatric and substance use problems. Although changes in cognition, mood, and personality have been described in association with hepatitis C and with IFN-alpha treatment, there has been little systematic study of these changes. Psychiatrists should become familiar with the clinical spectrum associated with hepatitis C virus infection as well as the neuropsychiatric symptoms related to hepatitis C and IFN-alpha treatment. More studies are necessary to define the neuropsychiatric syndromes associated with this population and to find possible effective treatments. Furthermore, research is needed so that patients with psychiatric problems are not excluded from effective treatments for this growing medical problem. JF - The American journal of psychiatry AU - Dieperink, E AU - Willenbring, M AU - Ho, S B AD - Department of Psychiatry, University of Minnesota and Minneapolis VA Medical Center 55417, USA. Vhamindiepee@MED.VA.GOV Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 867 EP - 876 VL - 157 IS - 6 SN - 0002-953X, 0002-953X KW - Antidepressive Agents KW - 0 KW - Antiviral Agents KW - Interferon-alpha KW - Narcotic Antagonists KW - Abridged Index Medicus KW - Index Medicus KW - Patient Education as Topic KW - Narcotic Antagonists -- therapeutic use KW - Depressive Disorder -- etiology KW - Depressive Disorder -- chemically induced KW - Humans KW - Antidepressive Agents -- therapeutic use KW - Exercise KW - Antiviral Agents -- therapeutic use KW - Interferon-alpha -- therapeutic use KW - Interferon-alpha -- adverse effects KW - Mental Disorders -- therapy KW - Mental Disorders -- chemically induced KW - Hepatitis C, Chronic -- epidemiology KW - Hepatitis C, Chronic -- drug therapy KW - Hepatitis C, Chronic -- complications KW - Mental Disorders -- etiology KW - Antiviral Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71149231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Neuropsychiatric+symptoms+associated+with+hepatitis+C+and+interferon+alpha%3A+A+review.&rft.au=Dieperink%2C+E%3BWillenbring%2C+M%3BHo%2C+S+B&rft.aulast=Dieperink&rft.aufirst=E&rft.date=2000-06-01&rft.volume=157&rft.issue=6&rft.spage=867&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-29 N1 - Date created - 2000-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cardiovascular fitness, body composition, and lipoprotein lipid metabolism in older men. AN - 18146068; 4867247 AB - BACKGROUND: Lipoprotein lipids in older individuals are affected by family history of coronary artery disease (CAD), obesity, diet, and physical activity habits. METHODS: The relationship of obesity and physical fitness (VO2max) to lipoprotein lipids and postheparin lipases was examined in a cross-sectional study of 12 lean (LS) and 26 obese (OS) sedentary men and 18 master athletes (MAs) aged 65+/-1 years (mean +/- SE). The men were healthy, had no family history of CAD, and were weight stable on AHA diets at the time of study. RESULTS: VO2max was similar in LS and OS men but higher in the MAs. The OS men had a higher percentage of body fat (%BF), waist circumference, and waist:hip ratio (WHR) than the MA and LS men, but MA and LS men differed only in waist circumference. Total and LDL-C levels were comparable, but HDL-C, HDL2-C, and %HDL2b subspecies were higher in MAs than in OS and LS men, and in LS than in OS men. Triglyceride (TG) was similar in MAs and LS men but higher in OS men. Across groups, two multiple regression analyses models (VO2max, %BF, and WHR or waist circumference) showed that %BF and VO2max independently predicted HDL-C and HDL2, whereas WHR predicted TG (r2 = .45) more strongly than waist circumference (r2 = .39). Postheparin lipoprotein lipase activity (LPL) was comparable among groups and correlated independently with VO2max. Total postheparin lipolytic activity (PHLA), hepatic lipase activity (HL), and HL:PHLA ratio were similar in MAs and LS men but higher in OS men. In both multiple regression analysis models, only %BF predicted HL activity and the HL:PHLA ratio. The HL:PHLA ratio independently predicted HDL-C, HDL2-C, %HDL2b, %HDL3 subspecies, and the cholesterol:HDL-C ratio, whereas LPL activity predicted TG. CONCLUSIONS: Increased fitness and reduced total and abdominal fatness in MAs are associated with lower HL and higher LPL activities, which may mediate their higher HDL-C and lower TG levels relative to their sedentary peers. JF - Journal of Gerontology. Series A AU - Goldberg, A P AU - Busby-Whitehead, MJ AU - Katzel, LI AU - Krauss, R M AU - Lumpkin, M AU - Hagberg, J M AD - Department of Medicine, University of Maryland School of Medicine, Baltimore Veterans Administration Maryland Health Care System, USA. apgoldbe.umaryland.edu. Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - M342 EP - M349 VL - 55 IS - 6 SN - 1079-5006, 1079-5006 KW - Physical Education Index KW - Physical fitness (age) KW - Men KW - Lipids KW - Geriatrics KW - Body composition KW - Cardiorespiratory endurance KW - Metabolism KW - Heart diseases KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18146068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Gerontology.+Series+A&rft.atitle=Cardiovascular+fitness%2C+body+composition%2C+and+lipoprotein+lipid+metabolism+in+older+men.&rft.au=Goldberg%2C+A+P%3BBusby-Whitehead%2C+MJ%3BKatzel%2C+LI%3BKrauss%2C+R+M%3BLumpkin%2C+M%3BHagberg%2C+J+M&rft.aulast=Goldberg&rft.aufirst=A&rft.date=2000-06-01&rft.volume=55&rft.issue=6&rft.spage=M342&rft.isbn=&rft.btitle=&rft.title=Journal+of+Gerontology.+Series+A&rft.issn=10795006&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Body composition; Metabolism; Lipids; Physical fitness (age); Geriatrics; Cardiorespiratory endurance; Heart diseases; Men ER - TY - JOUR T1 - Evaluation of Rifalazil in Long-Term Treatment Regimens for Tuberculosis in Mice AN - 17600275; 4715920 AB - Previous experiments with rifalazil (RLZ) (also known as KRM-1648) in combination with isoniazid (INH) demonstrated its potential for short-course treatment of Mycobacterium tuberculosis infection. In this study we investigated the minimum RLZ-INH treatment time required to eradicate M. tuberculosis in a murine model. RLZ-INH treatment for 6 weeks or longer led to a nonculturable state. Groups of mice treated in parallel were killed following an observation period to evaluate regrowth. RLZ-INH treatment for a minimum of 10 weeks was necessary to maintain a nonculturable state through the observation period. Pyrazinamide (PZA) was added to this regimen to determine whether the treatment duration could be further reduced. In this model, the addition of PZA did not shorten the duration of RLZ-INH treatment required to eradicate M. tuberculosis from mice. The addition of PZA reduced the number of mice in which regrowth occurred, although the reduction was not statistically significant. JF - Antimicrobial Agents & Chemotherapy AU - Shoen, C M AU - Chase, SE AU - DeStefano AU - Harpster, T S AU - Chmielewski, A J AU - Cynamon, M H AD - VAMC, 800 Irving Ave., Syracuse, NY 13210, USA, Michael.Cynamon@med.VA.gov Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 1458 EP - 1462 PB - American Society for Microbiology VL - 44 IS - 6 SN - 0066-4804, 0066-4804 KW - mice KW - rifalazil KW - Microbiology Abstracts B: Bacteriology KW - Lung KW - Tuberculosis KW - Antitubercular agents KW - Mycobacterium tuberculosis KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17600275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Evaluation+of+Rifalazil+in+Long-Term+Treatment+Regimens+for+Tuberculosis+in+Mice&rft.au=Shoen%2C+C+M%3BChase%2C+SE%3BDeStefano%3BHarpster%2C+T+S%3BChmielewski%2C+A+J%3BCynamon%2C+M+H&rft.aulast=Shoen&rft.aufirst=C&rft.date=2000-06-01&rft.volume=44&rft.issue=6&rft.spage=1458&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.44.6.1458-1462.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Tuberculosis; Antitubercular agents; Lung DO - http://dx.doi.org/10.1128/AAC.44.6.1458-1462.2000 ER - TY - JOUR T1 - Depression of constitutive murine cytochromes P450 by staphylococcal enterotoxin B. AN - 71003067; 10736430 AB - Most in vivo studies demonstrating decreased activities of hepatic cytochromes P450 with inflammation have used Gram-negative bacterial lipopolysaccharide (LPS) as the inflammatory stimulant. But products of Gram-positive bacteria, such as staphylococcal enterotoxin B (SEB), also stimulate inflammatory mediators, albeit with a different pattern than LPS. Therefore, effects of SEB on the regulation of murine constitutive P450s were determined in this study and compared with those of LPS. LPS-responsive C3H/HeN and LPS-unresponsive C3H/HeJ mice were injected with either LPS (0.5 mg/kg) or SEB (0.66 to 6.6 mg/kg), and hepatic cytochromes P450 and serum tumor necrosis factor-alpha, interleukin-6, nitrate/nitrite, and serum amyloid A concentrations were determined up to 24 hr. HeJ mice were generally less responsive than HeN mice to both stimuli, with lower cytokine, nitrate/nitrite, and serum amyloid A responses. However, in both mouse strains SEB caused more prolonged cytokine, higher nitrate/nitrite, and lower serum amyloid A concentrations than LPS. Despite these differences, in HeN mice, after both SEB and LPS administration, total P450 concentrations were equally depressed by 40%. Both SEB and LPS depressed CYP1A1 and 1A2 microsomal protein concentrations by 45 and 30%, respectively; CYP2E1 by 64%; and CYP3A by 70%. There was comparable inhibition of enzymatic activities. In HeJ mice, SEB was only slightly more effective in depressing P450s than LPS, as might be expected. These data showed that the Gram-positive bacterial inflammatory stimulant SEB caused effects on murine hepatic cytochromes P450 similar to those of LPS, even though the pattern of inflammatory mediators induced after SEB exposure was different. JF - Biochemical pharmacology AU - Shedlofsky, S I AU - Tosheva, R T AU - Snawder, J A AD - Department of Veterans Affairs Medical Center/University of Kentucky, Lexington, KY 40511, USA. Shedlofsky.Steve@Lexington.VA.Gov Y1 - 2000/05/15/ PY - 2000 DA - 2000 May 15 SP - 1295 EP - 1303 VL - 59 IS - 10 SN - 0006-2952, 0006-2952 KW - Enterotoxins KW - 0 KW - Inflammation Mediators KW - Lipopolysaccharides KW - enterotoxin B, staphylococcal KW - 39424-53-8 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Mice, Inbred C3H KW - Inflammation Mediators -- pharmacology KW - Mice KW - Staphylococcus aureus KW - Time Factors KW - Species Specificity KW - Male KW - Enterotoxins -- immunology KW - Lipopolysaccharides -- immunology KW - Cytochrome P-450 Enzyme System -- genetics KW - Lipopolysaccharides -- pharmacology KW - Lipopolysaccharides -- toxicity KW - Enterotoxins -- pharmacology KW - Cytochrome P-450 Enzyme System -- metabolism KW - Enterotoxins -- toxicity KW - Cytochrome P-450 Enzyme System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71003067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Depression+of+constitutive+murine+cytochromes+P450+by+staphylococcal+enterotoxin+B.&rft.au=Shedlofsky%2C+S+I%3BTosheva%2C+R+T%3BSnawder%2C+J+A&rft.aulast=Shedlofsky&rft.aufirst=S&rft.date=2000-05-15&rft.volume=59&rft.issue=10&rft.spage=1295&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-17 N1 - Date created - 2000-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Linguistic Validation of Four Parallel Forms of a Story Retelling Procedure AN - 85522786; 200011378 AB - This study reports the development & validation of four parallel forms of a story retelling procedure. The equivalency of forms was based on the performance of 15 adults with aphasia on 12 operationally defined productive language variables including measures of (1) verbal productivity, (2) information content, (3) grammatical well-formedness, (4) phoneme production, & (5) verbal disruptions. The results revealed no significant differences among the four forms of the test for any of the dependent measures, & strong, positive & significant correlations among forms for 11 of the 12 dependent measures. These results suggest that a wide variety of productive language variables can be reliably measured using parallel forms of the story-retelling procedure described herein. 5 Tables, 1 Appendix, 23 References. Adapted from the source document JF - Aphasiology AU - Doyle, Patrick J AU - McNeil, Malcolm R AU - Park, Grace AU - Goda, Amy AU - Rubenstein, Elaine AU - Spencer, Kristie AU - Carroll, Brian AU - Lustig, Amy AU - Szwarc, Leslie AD - Aphasia Rebilitation Research Laboratory & Clinic, VA Pittsburgh Healthcare System, VA Medical Center, PA patrick.doyle@med.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 537 EP - 549 VL - 14 IS - 5-6 SN - 0268-7038, 0268-7038 KW - Aphasia (03400) KW - Story Telling (84400) KW - Information Content (35890) KW - Measures (Instruments) (52300) KW - Well Formedness (96100) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85522786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Linguistic+Validation+of+Four+Parallel+Forms+of+a+Story+Retelling+Procedure&rft.au=Doyle%2C+Patrick+J%3BMcNeil%2C+Malcolm+R%3BPark%2C+Grace%3BGoda%2C+Amy%3BRubenstein%2C+Elaine%3BSpencer%2C+Kristie%3BCarroll%2C+Brian%3BLustig%2C+Amy%3BSzwarc%2C+Leslie&rft.aulast=Doyle&rft.aufirst=Patrick&rft.date=2000-05-01&rft.volume=14&rft.issue=5-6&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Story Telling (84400); Information Content (35890); Well Formedness (96100); Measures (Instruments) (52300) ER - TY - JOUR T1 - Significant interaction between clozapine and cocaine in cocaine addicts. AN - 71223990; 10891628 AB - Because clozapine may be prescribed to cocaine abusing patients with schizophrenia, we studied cocaine-clozapine interactions in a controlled setting. Eight male cocaine addicts underwent four oral challenges with ascending doses of clozapine (12.5, 25 and 50 mg) and placebo followed 2 h later by a 2-mg/kg dose of intranasal cocaine. Subjective and physiological responses, and serum cocaine levels were measured over a total 4-h period. Clozapine pretreatment increased cocaine levels during the study and significantly increased the peak serum cocaine levels in a dose dependent manner. In spite of this elevation in blood levels, clozapine pretreatment had a significant diminishing effect upon subjective responses to cocaine, including 'expected high', 'high' and 'rush', notably at the 50 mg dose. There was also a significant effect upon 'sleepiness', 'paranoia' and 'nervous'. Clozapine caused a significant near-syncopal episode in one subject in the study, requiring his removal from the study. Clozapine had no significant effect on baseline pulse rate and systolic blood pressure, but it attenuated the significant pressor effects of the single dose of intranasal cocaine. These data suggested a possible therapeutic role for clozapine in the treatment of cocaine addiction in humans, but also suggests caution due to the near-syncopal event and the increase in serum cocaine levels. JF - Drug and alcohol dependence AU - Farren, C K AU - Hameedi, F A AU - Rosen, M A AU - Woods, S AU - Jatlow, P AU - Kosten, T R AD - Department of Psychiatry, Division of Substance Abuse, Yale University School of Medicine, New Haven, CT, USA. conor.farren@med.va.gov Y1 - 2000/05/01/ PY - 2000 DA - 2000 May 01 SP - 153 EP - 163 VL - 59 IS - 2 SN - 0376-8716, 0376-8716 KW - Cocaine KW - I5Y540LHVR KW - Clozapine KW - J60AR2IKIC KW - Index Medicus KW - Euphoria -- drug effects KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Arousal -- drug effects KW - Risk Factors KW - Humans KW - Adult KW - Male KW - Comorbidity KW - Syncope -- chemically induced KW - Clozapine -- therapeutic use KW - Schizophrenia -- rehabilitation KW - Cocaine -- pharmacokinetics KW - Clozapine -- adverse effects KW - Cocaine-Related Disorders -- rehabilitation KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71223990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Significant+interaction+between+clozapine+and+cocaine+in+cocaine+addicts.&rft.au=Farren%2C+C+K%3BHameedi%2C+F+A%3BRosen%2C+M+A%3BWoods%2C+S%3BJatlow%2C+P%3BKosten%2C+T+R&rft.aulast=Farren&rft.aufirst=C&rft.date=2000-05-01&rft.volume=59&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-08 N1 - Date created - 2001-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hyperglycemia associated with protease inhibitors in an urban HIV-infected minority patient population. AN - 71175162; 10852083 AB - Hyperglycemia and new-onset diabetes mellitus have been reported to occur in HIV-infected patients treated with protease inhibitors. To determine the effect of protease inhibitor therapy on serum glucose in a predominantly minority patient population. Retrospective record review. Clinical HIV program of an urban Veterans Affairs medical center. All HIV-infected patients receiving a protease inhibitor over a one-year period from September 1996 through August 1997. One hundred seventeen patients not previously known to be diabetic received protease inhibitors; seven (6%) developed symptomatic diabetes mellitus. Eight other patients had one or more serum glucose values >150 mg/dL. Mean random glucose values for patients who did not develop diabetes were higher during therapy than prior to initiation of protease inhibitors. Urban minority HIV-infected patients receiving combination antiretroviral therapy including a protease inhibitor may be at increased risk for the development of hyperglycemia and diabetes mellitus. Risk factors for diabetes mellitus should be identified and blood glucose monitored in all patients receiving protease inhibitors. JF - The Annals of pharmacotherapy AU - Dever, L L AU - Oruwari, P A AU - Figueroa, W E AU - O'Donovan, C A AU - Eng, R H AD - Infectious Diseases Clinic, Veterans Affairs New Jersey Health Care System, East Orange 07018, USA. dever.lisa@east-orange.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 580 EP - 584 VL - 34 IS - 5 SN - 1060-0280, 1060-0280 KW - Blood Glucose KW - 0 KW - HIV Protease Inhibitors KW - Indinavir KW - 5W6YA9PKKH KW - Saquinavir KW - L3JE09KZ2F KW - Ritonavir KW - O3J8G9O825 KW - Index Medicus KW - AIDS/HIV KW - Urban Population -- statistics & numerical data KW - Humans KW - Minority Groups -- statistics & numerical data KW - Retrospective Studies KW - Indinavir -- therapeutic use KW - Blood Glucose -- analysis KW - Indinavir -- adverse effects KW - Saquinavir -- therapeutic use KW - Ritonavir -- therapeutic use KW - Risk Factors KW - Adult KW - Saquinavir -- adverse effects KW - Middle Aged KW - Ritonavir -- adverse effects KW - Female KW - Male KW - Hyperglycemia -- chemically induced KW - HIV Infections -- drug therapy KW - HIV Protease Inhibitors -- therapeutic use KW - HIV Protease Inhibitors -- adverse effects KW - Diabetes Mellitus, Type 2 -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71175162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Hyperglycemia+associated+with+protease+inhibitors+in+an+urban+HIV-infected+minority+patient+population.&rft.au=Dever%2C+L+L%3BOruwari%2C+P+A%3BFigueroa%2C+W+E%3BO%27Donovan%2C+C+A%3BEng%2C+R+H&rft.aulast=Dever&rft.aufirst=L&rft.date=2000-05-01&rft.volume=34&rft.issue=5&rft.spage=580&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-28 N1 - Date created - 2000-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estrogen potentiates treatment with T-cell receptor protein of female mice with experimental encephalomyelitis. AN - 71119639; 10811854 AB - Transgenic mice expressing the BV8S2 chain, which is specific for the myelin basic protein determinant Ac1-11, possess a naturally induced set of regulatory T cells directed against BV8S2. Further activation of anti-BV8S2 T cells in male mice with recombinant BV8S2 protein can inhibit IFN-gamma release by Ac1-11-specific T cells through a cytokine-driven mechanism and prevent induction of experimental autoimmune encephalomyelitis (EAE). In contrast, naive female mice possess fewer anti-BV8S2-reactive T cells, and treatment with BV8S2 delayed but did not prevent EAE. We here demonstrate that combining T-cell receptor (TCR) vaccination with supplemental estrus doses of estrogen potentiated IL-10 production by anti-BV8S2-reactive T cells and induced Ac1-11-specific T cells to produce IL-10 and TGF-beta. This combined treatment resulted in full protection against EAE, which was not observed with either therapy alone. These findings imply that supplemental estrogen can enhance the efficacy of TCR-based immunotherapy for autoimmune diseases that predominate in females. JF - The Journal of clinical investigation AU - Offner, H AU - Adlard, K AU - Zamora, A AU - Vandenbark, A A AD - Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97201, USA. offner.halina@portland.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 1465 EP - 1472 VL - 105 IS - 10 SN - 0021-9738, 0021-9738 KW - Myelin Basic Protein KW - 0 KW - Peptide Fragments KW - Receptors, Antigen, T-Cell KW - myelin basic protein 1-11 KW - Estradiol KW - 4TI98Z838E KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Myelin Basic Protein -- genetics KW - Peptide Fragments -- genetics KW - Sex Characteristics KW - Immunotherapy KW - Mice KW - Mice, Transgenic KW - Vaccination KW - Peptide Fragments -- immunology KW - Drug Synergism KW - Female KW - Male KW - Myelin Basic Protein -- immunology KW - Encephalomyelitis, Autoimmune, Experimental -- prevention & control KW - Estradiol -- administration & dosage KW - Receptors, Antigen, T-Cell -- administration & dosage KW - Encephalomyelitis, Autoimmune, Experimental -- immunology KW - Encephalomyelitis, Autoimmune, Experimental -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71119639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Estrogen+potentiates+treatment+with+T-cell+receptor+protein+of+female+mice+with+experimental+encephalomyelitis.&rft.au=Offner%2C+H%3BAdlard%2C+K%3BZamora%2C+A%3BVandenbark%2C+A+A&rft.aulast=Offner&rft.aufirst=H&rft.date=2000-05-01&rft.volume=105&rft.issue=10&rft.spage=1465&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-12 N1 - Date created - 2000-06-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arthritis Rheum. 1983 Sep;26(9):1155-9 [6615567] J Steroid Biochem. 1983 May;18(5):559-63 [6855231] Am J Reprod Immunol. 1984 Apr-May;5(3):109-13 [6204544] Ann Neurol. 1984 Aug;16(2):229-31 [6476794] J Neurol Sci. 1985 Apr;68(1):15-24 [3872929] Am J Pathol. 1985 Dec;121(3):531-51 [3907369] Leuk Res. 1985;9(11):1373-8 [4079452] J Neurol Sci. 1987 Jun;79(1-2):173-88 [2440996] Scand J Immunol. 1988 Sep;28(3):345-50 [2973658] Annu Rev Immunol. 1989;7:145-73 [2523712] J Immunol. 1990 Jun 15;144(12):4621-7 [1693637] Arch Neurol. 1990 Jul;47(7):738-42 [1972617] J Immunol. 1998 Oct 1;161(7):3299-306 [9759845] J Immunol. 1998 Oct 1;161(7):3365-74 [9759853] Arthritis Rheum. 1998 Nov;41(11):1919-29 [9811045] J Immunol. 1999 Jan 1;162(1):35-40 [9886367] J Immunol. 1991 May 15;146(10):3444-51 [1827484] J Steroid Biochem Mol Biol. 1991;40(4-6):619-37 [1958562] J Neuroimmunol. 1992 Jun;38(3):229-40 [1376328] Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6065-9 [1385868] Cell. 1993 Feb 26;72(4):551-60 [7679952] J Exp Med. 1993 Sep 1;178(3):909-16 [7688792] Immunol Today. 1993 Jul;14(7):353-6 [8363725] Int Arch Allergy Immunol. 1993;102(2):133-40 [8400893] J Immunol. 1993 Oct 15;151(8):4371-82 [7691946] Immunol Today. 1993 Dec;14(12):602-9 [8305133] Annu Rev Immunol. 1994;12:809-37 [8011298] Science. 1994 Aug 26;265(5176):1237-40 [7520605] J Neuroimmunol. 1994 Sep;53(2):203-7 [8071434] Immunol Today. 1994 Aug;15(8):356-61 [7916948] Science. 1994 Dec 2;266(5190):1524-7 [7985022] Cell. 1995 Mar 10;80(5):707-18 [7534215] J Neurosci Res. 1996 Feb 15;43(4):391-402 [8699526] Ann Neurol. 1996 Jun;39(6):724-33 [8651644] Nat Med. 1996 Oct;2(10):1109-15 [8837609] Neuroendocrinology. 1996 Aug;64(2):139-45 [8857608] Immunol Today. 1996 Apr;17(4):152-9 [8871344] J Neurosci Res. 1996 Aug 15;45(4):475-86 [8872909] J Neurosci Res. 1996 Sep 15;45(6):680-9 [8892079] Nat Med. 1996 Dec;2(12):1354-60 [8946835] J Immunol. 1997 Jan 1;158(1):446-51 [8977221] J Neurosci Res. 1997 Mar 1;47(5):489-99 [9067858] J Exp Med. 1997 May 5;185(9):1711-4 [9151908] J Exp Med. 1997 Jul 7;186(1):159-64 [9207010] J Exp Med. 1997 Jul 21;186(2):307-12 [9221760] Immunol Today. 1997 Oct;18(10):478-82 [9357139] FEBS Lett. 1998 Feb 6;422(3):349-53 [9498814] N Engl J Med. 1998 Jul 30;339(5):285-91 [9682040] J Immunol. 1998 Sep 1;161(5):2178-86 [9725209] Autoimmunity. 1999;31(4):237-48 [10789989] J Immunol. 1983 Jan;130(1):191-4 [6183347] J Immunol. 1983 Mar;130(3):1024-6 [6185565] J Immunol. 1983 Dec;131(6):2767-71 [6605988] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anger Management Group: Treatment for Cocaine Dependence: Preliminary Outcomes AN - 61661264; 200005799 AB - A sample of 59 men & 32 women with a diagnosis of cocaine dependence attended a 12-week anger management group treatment conducted in San Francisco, CA, & background substance abuse treatment. Levels of anger, negative affect, & anger control were measured at baseline, weekly during treatment, & at 3-month posttreatment follow-up. Levels of anger decreased & anger control increased between baseline & the end of treatment. End-of-treatment changes were maintained at follow-up. Findings were not moderated by gender, age, or psychiatric medication use. In the absence of a randomized control group, conclusive statements regarding the effectiveness of the anger management group treatment cannot be made; however, these preliminary findings demonstrate the need for a randomized clinical trial to test the efficacy of the anger management group treatment. 4 Figures, 16 References. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Reilly, Patrick M AU - Shopshire, Michael S AD - San Francisco Medical Center, CA reilly.patrick_m@sanfrancisco.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 161 EP - 177 VL - 26 IS - 2 SN - 0095-2990, 0095-2990 KW - Treatment Outcomes KW - Treatment Programs KW - Behavior Modification KW - Males KW - Group Therapy KW - Females KW - Cocaine KW - San Francisco, California KW - Anger KW - Drug Abuse KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61661264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Anger+Management+Group%3A+Treatment+for+Cocaine+Dependence%3A+Preliminary+Outcomes&rft.au=Reilly%2C+Patrick+M%3BShopshire%2C+Michael+S&rft.aulast=Reilly&rft.aufirst=Patrick&rft.date=2000-05-01&rft.volume=26&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Anger; Treatment Programs; Drug Abuse; Cocaine; Behavior Modification; Group Therapy; Treatment Outcomes; Males; Females; San Francisco, California ER - TY - JOUR T1 - Type IV collagen modulates angiogenesis and neovessel survival in the rat aorta model AN - 17668631; 4752727 AB - Type IV collagen is a major basement membrane component that has been implicated in the regulation of angiogenesis. The purpose of this study was to evaluate the effect of type IV collagen on the angiogenic response of native endothelial cells in three-dimensional vascular organ culture. Rings of rat aorta were cultured under serum-free conditions in gels of type I collagen with or without type IV collagen. In the absence of type IV collagen, aortic rings generated neovessels, which proliferated until day 9 and gradually regressed during the second and third weeks of culture. Type IV collagen promoted neovessel elongation and survival in a dose-dependent manner. Microvascular length increased by 43, 57, and 119% over control values in cultures treated with 3, 30, and 300 mu g/ml type IV collagen, respectively. When used at high concentrations (300 mu g/ml) type IV collagen stabilized the neovascular outgrowths and prevented vascular regression. Type IV collagen also promoted the formation of neovessels, but significant stimulatory effects were observed only at an intermediate concentration (30 mu g/ml) and were no longer significant at the high concentration (300 mu g/ml). The observation that type IV collagen has dose-dependent effects on vascular elongation, proliferation, and stabilization, supports the concept that the developing basement membrane of neovessels acts as a solid-phase regulator of angiogenesis, whose function varies depending on the concentration of its molecular components. JF - In Vitro Cellular & Developmental Biology - Animal AU - Bonanno, E AU - Iurlaro, M AU - Madri, JA AU - Nicosia, R F AD - Diagnostic Services, Division of Pathology and Laboratory Medicine (S-113-Lab), VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, Washington 98108, USA, Roberto.Nicosia@med.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 336 EP - 340 PB - [URL:http://journals.allenpress.com/jrnlserv/?request=get-abstract &issn=1071-2690&volume=36&page=336] VL - 36 IS - 5 SN - 1071-2690, 1071-2690 KW - rats KW - Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts KW - Collagen (type IV) KW - Blood vessels KW - Basement membranes KW - Aorta KW - Angiogenesis KW - W2 32070:Animals KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17668631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.atitle=Type+IV+collagen+modulates+angiogenesis+and+neovessel+survival+in+the+rat+aorta+model&rft.au=Bonanno%2C+E%3BIurlaro%2C+M%3BMadri%2C+JA%3BNicosia%2C+R+F&rft.aulast=Bonanno&rft.aufirst=E&rft.date=2000-05-01&rft.volume=36&rft.issue=5&rft.spage=336&rft.isbn=&rft.btitle=&rft.title=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.issn=10712690&rft_id=info:doi/10.1290%2F1071-2690%282000%29036%280336%3ATICMAA%292.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Collagen (type IV); Angiogenesis; Aorta; Basement membranes; Blood vessels DO - http://dx.doi.org/10.1290/1071-2690(2000)036(0336:TICMAA)2.0.CO;2 ER - TY - JOUR T1 - Occurrence and detection of AmpC beta-lactamases among Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates at a veterans medical center AN - 17553502; 4733966 AB - AmpC beta-lactamases are cephalosporinases that confer resistance to a wide variety of beta -lactam drugs and that may thereby create serious therapeutic problems. Although reported with increasing frequency, the true rate of occurrence of AmpC beta-lactamases in Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis remains unknown. We tested a total of 1,286 consecutive, nonrepeat isolates of these three species and found that, overall, 45 (3.5%) yielded a cefoxitin zone diameter less than 18 mm (screen positive) and that 16 (1.2%) demonstrated AmpC bands by isoelectric focusing. Based on the species, of 683 E. coli, 371 K. pneumoniae, and 232 P. mirabilis isolates tested, 13 (1.9%), 28 (7.6%), and 4 (1.7%), respectively, demonstrated decreased zone diameters and 11 (1.6%), 4 (1.1%), and 1 (0.4%), respectively, demonstrated AmpC bands. Cefoxitin resistance was transferred for all but 8 (E. coli) of the 16 AmpC producers. We also describe a three-dimensional extract test, which was used to detect phenotypically isolates that harbor AmpC beta-lactamase. Of the 45 cefoxitin-resistant isolates, the three-dimensional extract test accurately identified all 16 AmpC producers and 28 of 29 (97%) isolates as non-AmpC producers. Interestingly, most (86%) isolates in the latter group were K. pneumoniae isolates. These data confirm that, at our institution, E. coli, K. pneumoniae, and P. mirabilis harbor plasmid-mediated AmpC enzymes. JF - Journal of Clinical Microbiology AU - Coudron, P E AU - Moland, E S AU - Thomson, K S AD - Pathology and Laboratory Medicine Service/113, McGuire Veterans Affairs Medical Center, 1201 Broad Rock Blvd., Richmond, VA 23249-0001, USA, Philip.Coudron@med.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 1791 EP - 1796 VL - 38 IS - 5 SN - 0095-1137, 0095-1137 KW - AmpC protein KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Isoelectric focusing KW - Proteus mirabilis KW - Escherichia coli KW - b-Lactamase KW - Antibacterial agents KW - ^b-Lactamase KW - Cefoxitin KW - Antibiotic resistance KW - Klebsiella pneumoniae KW - A 01064:Microbial resistance KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17553502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Occurrence+and+detection+of+AmpC+beta-lactamases+among+Escherichia+coli%2C+Klebsiella+pneumoniae%2C+and+Proteus+mirabilis+isolates+at+a+veterans+medical+center&rft.au=Coudron%2C+P+E%3BMoland%2C+E+S%3BThomson%2C+K+S&rft.aulast=Coudron&rft.aufirst=P&rft.date=2000-05-01&rft.volume=38&rft.issue=5&rft.spage=1791&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Proteus mirabilis; Klebsiella pneumoniae; b-Lactamase; Antibacterial agents; Cefoxitin; Antibiotic resistance; Isoelectric focusing; ^b-Lactamase ER - TY - JOUR T1 - Geographic distribution of a large mobile element that transfers ampicillin and vancomycin resistance between Enterococcus faecium strains AN - 17544679; 4724011 AB - In several clonally unrelated VanB-type vancomycin-resistant Enterococcus faecium strains, we demonstrated a common physical relationship between pbp5 and Tn5382 as well as common mutations within pbp5. The majority of these strains transferred vancomycin and ampicillin resistance to E. faecium in vitro, suggesting the dissemination of similar transferable pbp5-vanB-containing mobile elements throughout the United States. JF - Antimicrobial Agents & Chemotherapy AU - Hanrahan, J AU - Hoyen, C AU - Rice, L B AD - Medical Service 111(W), VA Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA, louis.rice@med.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 1349 EP - 1351 VL - 44 IS - 5 SN - 0066-4804, 0066-4804 KW - Transposon Tn5382 KW - USA KW - pbp5 gene KW - Microbiology Abstracts B: Bacteriology KW - Geographical distribution KW - Gene transfer KW - Drug resistance KW - Vancomycin KW - Ampicillin KW - Antibacterial agents KW - Mutation KW - Enterococcus faecium KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17544679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Geographic+distribution+of+a+large+mobile+element+that+transfers+ampicillin+and+vancomycin+resistance+between+Enterococcus+faecium+strains&rft.au=Hanrahan%2C+J%3BHoyen%2C+C%3BRice%2C+L+B&rft.aulast=Hanrahan&rft.aufirst=J&rft.date=2000-05-01&rft.volume=44&rft.issue=5&rft.spage=1349&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.44.5.1349-1351.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Enterococcus faecium; Antibacterial agents; Ampicillin; Vancomycin; Drug resistance; Mutation; Gene transfer; Geographical distribution DO - http://dx.doi.org/10.1128/AAC.44.5.1349-1351.2000 ER - TY - JOUR T1 - Illnesses Among United States Veterans of the Gulf War: A Population-Based Survey of 30,000 Veterans AN - 17531830; 4718500 AB - Despite numerous studies on veterans of the 1990 to 1991 Gulf War, the fundamental questions of how healthy they are and how their health compares with that of their military peers who were not deployed to the Gulf have not been fully answered. We conducted a health survey in which the health outcomes of a population-based sample of 15,000 Gulf veterans representing various military branches and unit components (regular, reserve, National Guard) were compared with those of 15,000 non-Gulf veterans who were randomly sampled to mirror the number in the same military strata in the Gulf veteran group. In comparison with their peers, Gulf veterans had a higher prevalence of functional impairment, health care utilization, symptoms, and medical conditions and a higher rate of low general health perceptions. A longitudinal follow-up of the health of these veterans will be needed to detect changes in health status and to detect diseases with a long latency period. JF - Journal of Occupational and Environmental Medicine AU - Kang, H K AU - Mahan, C M AU - Lee, KY AU - Magee, CA AU - Murphy, F M AD - Environmental Epidemiology Service, Department of Veterans Affairs, 1120 20th Street NW Suite 950, Washington, DC 20036, USA, han.kang@mail.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 VL - 42 IS - 5 SN - 1076-2752, 1076-2752 KW - Persian Gulf KW - USA KW - population studies KW - Health & Safety Science Abstracts KW - occupational diseases KW - Military KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17531830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Illnesses+Among+United+States+Veterans+of+the+Gulf+War%3A+A+Population-Based+Survey+of+30%2C000+Veterans&rft.au=Kang%2C+H+K%3BMahan%2C+C+M%3BLee%2C+KY%3BMagee%2C+CA%3BMurphy%2C+F+M&rft.aulast=Kang&rft.aufirst=H&rft.date=2000-05-01&rft.volume=42&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Military; Occupational health; occupational diseases ER - TY - JOUR T1 - Chemodenervation of the rat hemilarynx with phenol. AN - 85366398; pmid-10778888 AB - In this study, the injection of phenol into the true vocal fold was evaluated on a rat model as a possible treatment for adductor spasmodic dysphonia. A 10% phenol solution was injected into the right true vocal fold. Quantitative measurement of vocal fold adductory force showed reduction to 35% of the preinjection value 3 months after injection (p < .05). Qualitative evaluation by videolaryngoscopy demonstrated maintenance of the normal vocal fold range of motion. Histologic studies showed a transient inflammatory infiltrate and myolysis, while the vocal fold mucosa and the cricoarytenoid joints remained undamaged. Further investigation into the potential use of phenol for treating spasmodic dysphonia is warranted. JF - The Annals of otology, rhinology, and laryngology AU - Nguyen, T AU - Paniello, R C AD - Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, and the Veterans Administration Medical Center, St Louis, Missouri, USA. Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 355 EP - 359 VL - 109 IS - 4 SN - 0003-4894, 0003-4894 KW - National Library of Medicine KW - Rats KW - Laryngismus -- therapy KW - Animals KW - Rats, Sprague-Dawley KW - Laryngeal Muscles KW - Voice Disorders -- etiology KW - Laryngismus -- complications KW - Vagotomy KW - Laryngoscopy KW - Injections KW - Male KW - Voice Disorders -- therapy KW - Vocal Cords -- pathology KW - Vocal Cords -- physiology KW - Vocal Cords -- innervation KW - Phenol -- administration & dosage KW - Denervation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85366398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.atitle=Chemodenervation+of+the+rat+hemilarynx+with+phenol.&rft.au=Nguyen%2C+T%3BPaniello%2C+R+C&rft.aulast=Nguyen&rft.aufirst=T&rft.date=2000-04-01&rft.volume=109&rft.issue=4&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.issn=00034894&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - A multinational comparison of aphasia management practices. AN - 85345115; pmid-10912257 AB - The effect of restructuring of healthcare on the quality, quantity, and nature of aphasia management is largely unknown. The current study is the first to examine access, diagnostic, treatment, and discharge patterns of patients with aphasia in Australia, Canada, the UK, the US private sector (US-Private), and the US Veterans Health Administration in the Department of Veterans Affairs (US-VA). The authors developed a 37-item survey to be completed by clinicians working with aphasic patients. The survey focused on eight areas: access to care, evaluation procedures, group treatment, number and duration of treatment sessions, limitations of the number of sessions, termination of treatment, follow-up practices, and resumption of treatment. 394 surveys were distributed and 175 were returned completed (44% return rate). Respondents represented a range of ages, work experiences, and work settings. There was considerable consistency among respondents from our five healthcare systems. Results suggest that patients may be routinely denied treatment in direct contradiction to the research literature. Just as we carefully monitor the progress of patients receiving our treatment, we are obliged to monitor the effects of managed care on our patients, fellow clinicians, and our profession. JF - International journal of language & communication disorders / Royal College of Speech & Language Therapists AU - Katz, R C AU - Hallowell, B AU - Code, C AU - Armstrong, E AU - Roberts, P AU - Pound, C AU - Katz, L AD - Audiology and Speech Pathology Department (CS/126), Carl T. Hayden VA Medical Center, Phoenix, AZ 85012-1892, USA. richard.katz@med.va.gov Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 303 EP - 314 VL - 35 IS - 2 SN - 1368-2822, 1368-2822 KW - Index Medicus KW - National Library of Medicine KW - Canada -- epidemiology KW - Australia -- epidemiology KW - Aphasia -- epidemiology KW - Quality of Health Care KW - Humans KW - Health Services Accessibility -- standards KW - Treatment Outcome KW - Americas -- epidemiology KW - Great Britain -- epidemiology KW - Aphasia -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85345115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+language+%26+communication+disorders+%2F+Royal+College+of+Speech+%26+Language+Therapists&rft.atitle=A+multinational+comparison+of+aphasia+management+practices.&rft.au=Katz%2C+R+C%3BHallowell%2C+B%3BCode%2C+C%3BArmstrong%2C+E%3BRoberts%2C+P%3BPound%2C+C%3BKatz%2C+L&rft.aulast=Katz&rft.aufirst=R&rft.date=2000-04-01&rft.volume=35&rft.issue=2&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=International+journal+of+language+%26+communication+disorders+%2F+Royal+College+of+Speech+%26+Language+Therapists&rft.issn=13682822&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Health-related quality of life in Parkinson's disease after pallidotomy and deep brain stimulation. AN - 85343916; pmid-10753487 AB - This study explored the multidimensional outcome of three neurosurgical interventions for Parkinson's disease (PD): pallidotomy (N = 23), pallidal deep brain stimulation (DBS) (N = 9), and thalamic DBS (N = 7). All patients completed the Sickness Impact Profile (SIP) and the Beck Depression Inventory. Pallidotomy patients also completed the Profile of Mood States, the Beck Anxiety Inventory, and a disease-specific quality of life (QOL) measure, the Parkinson's Disease Questionnaire (PDQ-39). Three months after surgery, all neurosurgical groups showed significant improvements in mood and function, including physical, psychosocial, and overall functioning. Pallidal DBS and pallidotomy patients who completed additional QOL measures reported decreased anxiety and tension, increased vigor, improved mobility and ability to perform activities of daily living, and decreased perceived stigma. Psychosocial dysfunction scores from the SIP were related to depressed mood both at baseline (r = .42) and at followup (r = .45), but the physical dysfunction subscale was not related to mood at either time point, suggesting that disruption of social relationships due to PD may have more impact on affective distress than physical symptoms alone. Results suggest that neurosurgical interventions for PD improve disabling PD motor symptoms and also improve several domains of quality of life. Copyright 2000 Academic Press. JF - Brain and cognition AU - Straits-Tröster, K AU - Fields, J A AU - Wilkinson, S B AU - Pahwa, R AU - Lyons, K E AU - Koller, W C AU - Tröster, A I AD - Department of Veterans Affairs Medical Center, Kansas City, USA. troster@kansas-city.va.gov Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 399 EP - 416 VL - 42 IS - 3 SN - 0278-2626, 0278-2626 KW - Index Medicus KW - National Library of Medicine KW - Electric Stimulation -- methods KW - Anxiety -- psychology KW - Humans KW - Neurosurgical Procedures -- methods KW - Activities of Daily Living KW - Aged KW - Depression -- diagnosis KW - Globus Pallidus -- surgery KW - Globus Pallidus -- physiology KW - Brain -- physiology KW - Psychomotor Disorders -- diagnosis KW - Anxiety -- diagnosis KW - Depression -- psychology KW - Treatment Outcome KW - Middle Aged KW - Health Status KW - Quality of Life KW - Parkinson Disease -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85343916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+cognition&rft.atitle=Health-related+quality+of+life+in+Parkinson%27s+disease+after+pallidotomy+and+deep+brain+stimulation.&rft.au=Straits-Tr%C3%B6ster%2C+K%3BFields%2C+J+A%3BWilkinson%2C+S+B%3BPahwa%2C+R%3BLyons%2C+K+E%3BKoller%2C+W+C%3BTr%C3%B6ster%2C+A+I&rft.aulast=Straits-Tr%C3%B6ster&rft.aufirst=K&rft.date=2000-04-01&rft.volume=42&rft.issue=3&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Brain+and+cognition&rft.issn=02782626&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - The short- and long-term efficacy of empirical esophageal dilation in patients with nonobstructive dysphagia: a prospective, randomized study. AN - 85340474; pmid-10763936 AB - OBJECTIVE: The efficacy of empirical esophageal dilation for nonobstructive dysphagia (NOD) is unknown. Our aim was to assess the efficacy and safety of empirical dilation with a large bougie in patients with NOD. METHODS: Patients with NOD (normal barium swallow, free passage of a 13-mm barium pill, and normal esophagogastroduodenoscopy) were randomized to dilation with either a 50-Fr (Group A) or 26-Fr (Group B) Maloney dilator. Before dilation, the dysphagia (DyspSC) and diet (DietSc) scores were recorded and an esophageal manometry performed. Both scores were reassessed at 1, 3, 7, and 14 days after dilation. Success was defined at day 14 as an improvement in the DietSc of at least 25% from baseline, or a DyspSc of < or =3. Nonresponders were crossed-over to the alternate dilator and restudied. RESULTS: Twenty-three patients (58.7+/-1.9 yr) were enrolled: 13 in Group A and 10 in Group B. Both groups were matched for age, baseline DyspSc (4.2+/-0.6 vs 3.8+/-0.5), baseline DietSc (13.3+/-1.7 vs 12.0+/-1.9), and manometric findings. A nonspecific motility disorder was seen in 43.4% patients. Group A had an initial response rate significantly greater (84.6%) than Group B (40%) (p = 0.03; odds ratio [OR] = 8.25). The DyspSc and DietSc were better than baseline with both dilators, but only the DietSc improved significantly in patients dilated with the 50-Fr dilator (5.3+/-1.9 vs 12.3+/-1.4; p = 0.004). At 2 yr, 80% of the patients responding to the 50-Fr Maloney had a sustained response. CONCLUSION: Empirical dilation with a large (50-Fr) bougie is safe, effective, and long-lasting in improving nonobstructive dysphagia. JF - The American journal of gastroenterology AU - Colon, V J AU - Young, M A AU - Ramirez, F C AD - Department of Medicine, Carl T. Hayden Veterans Administration Medical Center, Phoenix, Arizona 85012, USA. Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 910 EP - 913 VL - 95 IS - 4 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Equipment Design KW - Deglutition Disorders -- therapy KW - Prospective Studies KW - Humans KW - Treatment Outcome KW - Follow-Up Studies KW - Middle Aged KW - Female KW - Male KW - Deglutition Disorders -- etiology KW - Dilatation -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85340474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=The+short-+and+long-term+efficacy+of+empirical+esophageal+dilation+in+patients+with+nonobstructive+dysphagia%3A+a+prospective%2C+randomized+study.&rft.au=Colon%2C+V+J%3BYoung%2C+M+A%3BRamirez%2C+F+C&rft.aulast=Colon&rft.aufirst=V&rft.date=2000-04-01&rft.volume=95&rft.issue=4&rft.spage=910&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - SuppNotes - Comment In: Am J Gastroenterol. 2001 Oct;96(10):3036[11693349] N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Changing strategies for treatment of systemic mycoses. AN - 72309677; 11012295 AB - There have been a number of changes in strategies in antifungal therapy in the past few years. AIDS related mycoses have decreased, and the increase of fluconazole resistant Candida albicans may be slowing because fewer severely immune depressed patients require constant fluconazole suppression. Candida species continue to be relatively common blood culture isolates. About half of these are C. albicans and half non-albicans species. In recent years, we have moved from the use of amphotericin B to fluconazole for initial treatment of candidemia. We have seen fluconazole resistant isolates emerge, primarily C. glabrata and a few C. krusei, but also C. albicans. It is unclear whether the increasing use of fluconazole in intensive care units will worsen this problem. There appears to be no advantage for the lipid formulations of amphotericin B, though they are useful to reduce or prevent renal toxicity. In the United States and Europe, prevention and treatment of aspergillosis have become increasingly important. There are increasing data suggesting that lipid formulations are more effective for both treatment and prevention of invasive disease in the most vulnerable patients with this infection. Renal toxicity is reduced but not avoided by use of the lipid formulations of amphotericin B. For those patients with less acutely progressing disease, the triazoles may be effective options. It is unclear at present whether itraconazole, voriconazole, or posaconazole will be the most favored drug. One promising new class, now in clinical trials, is the echinocandin group. Other agents, such as the sordarins, the chitin synthase inhibitors, and topoisomerase inhibitors, have promise but are much earlier in development. Unfortunately, we still have >50% treatment failure with acute invasive aspergillosis, and 20%-30% failures with candidemia. Now that we have multiple classes of antifungal drugs available, and others in preclinical trials, it would be advantageous to begin more active exploration of combination therapy with antifungals and with combined immune modulators and antifungals. JF - The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases AU - Graybill, J R AD - Department of Medicine, Veterans Administration Hospital, San Antonio, TX 78284, USA. Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 47 EP - 54 VL - 4 IS - 2 SN - 1413-8670, 1413-8670 KW - Antifungal Agents KW - 0 KW - Amphotericin B KW - 7XU7A7DROE KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Fluconazole KW - 8VZV102JFY KW - Index Medicus KW - AIDS/HIV KW - Fluconazole -- therapeutic use KW - Humans KW - Drug Resistance, Microbial KW - Granulocyte-Macrophage Colony-Stimulating Factor -- therapeutic use KW - Amphotericin B -- therapeutic use KW - Antifungal Agents -- therapeutic use KW - Mycoses -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72309677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Brazilian+journal+of+infectious+diseases+%3A+an+official+publication+of+the+Brazilian+Society+of+Infectious+Diseases&rft.atitle=Changing+strategies+for+treatment+of+systemic+mycoses.&rft.au=Graybill%2C+J+R&rft.aulast=Graybill&rft.aufirst=J&rft.date=2000-04-01&rft.volume=4&rft.issue=2&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=The+Brazilian+journal+of+infectious+diseases+%3A+an+official+publication+of+the+Brazilian+Society+of+Infectious+Diseases&rft.issn=14138670&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-28 N1 - Date created - 2000-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Efficacy of hydroquinone cream (USP 4%) used alone or in combination with salicylic acid peels in improving photodamage on the neck and upper chest. AN - 71059277; 10759820 AB - Salicylic acid, hydroquinone, and glycolic acid have been proved effective in the treatment of photodamaged facial skin. Few reports are available on the treatment of photodamage on the neck and upper chest. This study's purpose was to evaluate the efficacy of a cream containing 4% hydroquinone and 2% glycolic acid (LUSTRA) used alone or with salicylic acid peels in reversing actinic damage on the neck and upper chest. Nineteen women with moderate to advanced photodamage on the neck and upper chest applied a cream containing 4% hydroquinone and 2% glycolic acid twice daily on photodamaged areas for 12 weeks. Nine of these subjects had salicylic acid peels every 3 weeks. Improvements were assessed by the investigator, the subjects, and Mexameter readings measuring melanin and erythema levels. The result shows that there was a 33-71% improvement in photodamage, hyperpigmentation, texture, fine lines, dryness, tone, and clarity in both groups. There were no significant differences between the two treatments. Hydroquinone 4% cream with 2% glycolic acid is safe and effective in improving photodamage on the neck and upper chest when used alone or in combination with salicylic acid peels. JF - Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] AU - Gladstone, H B AU - Nguyen, S L AU - Williams, R AU - Ottomeyer, T AU - Wortzman, M AU - Jeffers, M AU - Moy, R L AD - Division of Dermatology, UCLA School of Medicine, and Veterans Administration, West Los AngelesMedical Center, Los Angeles, California, USA. Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 333 EP - 337 VL - 26 IS - 4 SN - 1076-0512, 1076-0512 KW - Glycolates KW - 0 KW - Hydroquinones KW - Keratolytic Agents KW - Ointments KW - glycolic acid KW - 0WT12SX38S KW - Monophenol Monooxygenase KW - EC 1.14.18.1 KW - Salicylic Acid KW - O414PZ4LPZ KW - hydroquinone KW - XV74C1N1AE KW - Index Medicus KW - Hyperpigmentation -- pathology KW - Hyperpigmentation -- therapy KW - Humans KW - Monophenol Monooxygenase -- antagonists & inhibitors KW - Glycolates -- administration & dosage KW - Female KW - Hydroquinones -- adverse effects KW - Thorax KW - Skin Aging -- drug effects KW - Hydroquinones -- administration & dosage KW - Neck KW - Chemexfoliation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71059277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dermatologic+surgery+%3A+official+publication+for+American+Society+for+Dermatologic+Surgery+%5Bet+al.%5D&rft.atitle=Efficacy+of+hydroquinone+cream+%28USP+4%25%29+used+alone+or+in+combination+with+salicylic+acid+peels+in+improving+photodamage+on+the+neck+and+upper+chest.&rft.au=Gladstone%2C+H+B%3BNguyen%2C+S+L%3BWilliams%2C+R%3BOttomeyer%2C+T%3BWortzman%2C+M%3BJeffers%2C+M%3BMoy%2C+R+L&rft.aulast=Gladstone&rft.aufirst=H&rft.date=2000-04-01&rft.volume=26&rft.issue=4&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Dermatologic+surgery+%3A+official+publication+for+American+Society+for+Dermatologic+Surgery+%5Bet+al.%5D&rft.issn=10760512&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-15 N1 - Date created - 2000-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epididymo-orchitis following intravesical bacillus Calmette-Guérin therapy. AN - 71046048; 10772435 AB - To describe a case of epididymo-orchitis that developed four years after treatment with intravesical bacillus Calmette-Guérin (BCG) and to review the incidence of this adverse effect. Information about the patient was obtained from the medical chart. A MEDLINE search of English-language literature (from January 1976 to April 1999) was conducted. All case reports of BCG-related epididymo-orchitis were evaluated. Review articles describing complications of BCG therapy for bladder cancer and the prevention and treatment of these complications were reviewed. Studies were evaluated for reports of BCG-related epididymo-orchitis and its treatment. Our case report is compared with others reported in the literature. The incidence of BCG-associated epididymoorchitis is rare. Epididymo-orchitis should be considered as a late complication of BCG therapy for bladder cancer. Proper patient selection may help decrease the risk of complications from BCG therapy. JF - The Annals of pharmacotherapy AU - Menke, J J AU - Heins, J R AD - South Dakota State University, Brookings, USA. Jennifer.menke@med.va.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 479 EP - 482 VL - 34 IS - 4 SN - 1060-0280, 1060-0280 KW - Adjuvants, Immunologic KW - 0 KW - BCG Vaccine KW - Index Medicus KW - Carcinoma, Transitional Cell -- complications KW - Humans KW - Urinary Bladder Neoplasms -- drug therapy KW - Incidence KW - Aged KW - Male KW - Carcinoma, Transitional Cell -- drug therapy KW - Administration, Intravesical KW - Urinary Bladder Neoplasms -- complications KW - Orchitis -- complications KW - BCG Vaccine -- therapeutic use KW - BCG Vaccine -- adverse effects KW - Orchitis -- epidemiology KW - Epididymitis -- complications KW - Adjuvants, Immunologic -- adverse effects KW - Orchitis -- chemically induced KW - Epididymitis -- epidemiology KW - Adjuvants, Immunologic -- therapeutic use KW - Epididymitis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71046048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Epididymo-orchitis+following+intravesical+bacillus+Calmette-Gu%C3%A9rin+therapy.&rft.au=Menke%2C+J+J%3BHeins%2C+J+R&rft.aulast=Menke&rft.aufirst=J&rft.date=2000-04-01&rft.volume=34&rft.issue=4&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-23 N1 - Date created - 2000-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Homocysteine. AN - 71043199; 10762063 AB - Homocysteine does not occur in the diet but it is an essential intermediate in normal mammalian metabolism of methionine. Each compound, methionine or homocysteine, is the precursor of the other. Similarly, the synthesis of one is the mechanism for the detoxification of the other. The ubiquitous methionine cycle is the metabolic basis for this relationship. In some tissues the transsulfuration pathway diverts homocysteine from the cycle and provides a means for the synthesis of cysteine and its derivatives. Methionine, (or homocysteine) metabolism is regulated by the disposition of homocysteine between these competing sequences. Both pathways require vitamin-derived cofactors, pyridoxine for transsulfuration and both folate and cobalamin in the methionine cycle. The clinical consequences of disruption of these pathways was apparent first in rare inborn errors of metabolism that cause homocystinuria, but recent studies focus on "hyperhomocysteinemia"--a lesser metabolic impairment that may result from genetic variations, acquired pathology, toxicity and nutritional inadequacy. Hyperhomocysteinemia is an independent risk factor for thrombovascular diseases however it is not clear whether the minimally increased concentration of the amino acid is the causative agent or merely a marker for the pathology. Until we resolve that question we cannot predict the potential efficacy of therapies based on folate administration with or without additional cobalamin and pyridoxine. JF - The international journal of biochemistry & cell biology AU - Finkelstein, J D AU - Martin, J J AD - VA Medical Center, Washington DC 20422, USA. James.finkelstein@med.va.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 385 EP - 389 VL - 32 IS - 4 SN - 1357-2725, 1357-2725 KW - Homocysteine KW - 0LVT1QZ0BA KW - Index Medicus KW - Animals KW - Humans KW - Homocysteine -- metabolism KW - Homocysteine -- deficiency KW - Homocysteine -- chemistry KW - Homocysteine -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71043199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+international+journal+of+biochemistry+%26+cell+biology&rft.atitle=Homocysteine.&rft.au=Finkelstein%2C+J+D%3BMartin%2C+J+J&rft.aulast=Finkelstein&rft.aufirst=J&rft.date=2000-04-01&rft.volume=32&rft.issue=4&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=The+international+journal+of+biochemistry+%26+cell+biology&rft.issn=13572725&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-19 N1 - Date created - 2000-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nefazodone treatment for chronic posttraumatic stress disorder: an open trial. AN - 71038628; 10770453 AB - Currently, there is no standard treatment for posttraumatic stress disorder (PTSD) because of a deficit of systematic treatment trials. The symptom overlap with other mood and anxiety disorders that respond to antidepressants and the results of a limited number of antidepressant trials indicate promise for psychopharmacologic treatment. Several open trials and one controlled trial with selective serotonin reuptake inhibitors have reported improvement in the symptomatology of PTSD. In this study, a relatively new serotonergic antidepressant, nefazodone, was tested as a treatment for PTSD. Veterans with chronic PTSD (N = 36) were enrolled in an 8-week open-label trial of nefazodone. The primary outcome measure was the Clinician-Administered PTSD Scale (CAPS). Thirty-one patients completed at least 4 weeks of treatment, which was considered to be an adequate trial, and 26 patients completed the 8-week study. During treatment, there was a significant decrease in the total CAPS score and in each of three CAPS subscale scores, with most of the improvement occurring during the first 4 weeks. Comparable improvements were also seen on the Hamilton Rating Scales for Anxiety and for Depression. Nefazodone treatment was well tolerated by this patient population, with only four patients discontinuing because of adverse effects. In summary, nefazodone treatment improved the symptoms of PTSD, including the core symptoms. Placebo-controlled studies should be undertaken to further elucidate the efficacy of nefazodone in the treatment of PTSD. JF - Journal of clinical psychopharmacology AU - Davis, L L AU - Nugent, A L AU - Murray, J AU - Kramer, G L AU - Petty, F AD - Department of Veterans Affairs Medical Center at Tuscaloosa, Alabama 35404, USA. Davis.Lori@Tuscaloosa.va.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 159 EP - 164 VL - 20 IS - 2 SN - 0271-0749, 0271-0749 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Triazoles KW - nefazodone KW - 59H4FCV1TF KW - Index Medicus KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Personality Inventory KW - Middle Aged KW - Chronic Disease KW - Male KW - Female KW - Combat Disorders -- psychology KW - Antidepressive Agents, Second-Generation -- adverse effects KW - Antidepressive Agents, Second-Generation -- therapeutic use KW - Stress Disorders, Post-Traumatic -- psychology KW - Combat Disorders -- drug therapy KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Veterans -- psychology KW - Combat Disorders -- diagnosis KW - Triazoles -- therapeutic use KW - Triazoles -- adverse effects KW - Stress Disorders, Post-Traumatic -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71038628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Nefazodone+treatment+for+chronic+posttraumatic+stress+disorder%3A+an+open+trial.&rft.au=Davis%2C+L+L%3BNugent%2C+A+L%3BMurray%2C+J%3BKramer%2C+G+L%3BPetty%2C+F&rft.aulast=Davis&rft.aufirst=L&rft.date=2000-04-01&rft.volume=20&rft.issue=2&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-28 N1 - Date created - 2000-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. AN - 71035483; 10735785 AB - We tested the hypothesis that L-arginine (the substrate for nitric oxide production)-combined with amrinone, milrinone (Type III phosphodiesterase [PDE] inhibitors), zaprinast, or sildenafil (Type V PDE inhibitors)-would vasodilate synergistically. Internal mammary artery segments were excised from anesthetized swine, divided into rings, and suspended in a tissue bath at 37 degrees C. Force of contraction was measured during dose-response testing of combinations of L-arginine and amrinone, milrinone, zaprinast, or sildenafil. Amrinone and milrinone were additive to L-arginine. N(G)-methyl-L-arginine (L-NMA) inhibited the effects of milrinone but not amrinone. The effective concentration of amrinone eliciting 50% relaxation (EC(50)) was 3.8E-05M (n = 6) when given alone and 4. 4E-05M (n = 6) with L-NMA. Milrinone had EC(50) = 6.0E-06M alone (n = 6) and 2.8E-05M (n = 6) with L-NMA. Zaprinast (EC(50) = 6.5E-05M, n = 6) and sildenafil (EC(30) = 1.8E-05M, n = 6) were synergistic with L-arginine. L-NMA blocked their effects, increasing the EC(50) for zaprinast to 9.9E-03M and the EC(30) for sildenafil to 6.1E+02M. In conclusion, L-arginine is additive to the vasodilation of the type III PDE inhibitors, amrinone and milrinone, but synergistic with the type V PDE inhibitors, zaprinast and sildenafil. Amrinone and milrinone, Type III cAMP-dependent phosphodiesterase inhibitors, are additive to L-arginine-dependent vasodilation. Zaprinast and sildenafil, Type V cGMP-dependent phosphodiesterase inhibitors, are synergistic with L-arginine. JF - Anesthesia and analgesia AU - Wallace, A W AU - Tom, W L AD - Department of Anesthesiology, San Francisco Veterans Administration Medical Center and Department of Anesthesiology, University of California-San Francisco, San Francisco, California, USA. awallace@best.com Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 840 EP - 846 VL - 90 IS - 4 SN - 0003-2999, 0003-2999 KW - Phosphodiesterase Inhibitors KW - 0 KW - omega-N-Methylarginine KW - 27JT06E6GR KW - Arginine KW - 94ZLA3W45F KW - Cyclic GMP KW - H2D2X058MU KW - Abridged Index Medicus KW - Index Medicus KW - Swine KW - Animals KW - Dose-Response Relationship, Drug KW - Cyclic GMP -- physiology KW - omega-N-Methylarginine -- pharmacology KW - Drug Synergism KW - Phosphodiesterase Inhibitors -- pharmacology KW - Mammary Arteries -- drug effects KW - Vasodilation -- drug effects KW - Mammary Arteries -- physiology KW - Arginine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71035483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Interaction+of+L-arginine+and+phosphodiesterase+inhibitors+in+vasodilation+of+the+porcine+internal+mammary+artery.&rft.au=Wallace%2C+A+W%3BTom%2C+W+L&rft.aulast=Wallace&rft.aufirst=A&rft.date=2000-04-01&rft.volume=90&rft.issue=4&rft.spage=840&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=00032999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-20 N1 - Date created - 2000-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pediatric immunization for the future. Lyme disease vaccine and beyond. AN - 71031278; 10761515 AB - This article highlights some of the exciting new developments in pediatric immunization. Starting with the newly licensed Lyme disease vaccine, which is not yet approved for children younger than 15 years of age, the article discusses potential vaccines for severe allergy and cocaine abuse and stresses some of the new techniques in needleless vaccination, including the edible plant technology. JF - Pediatric clinics of North America AU - Lutwick, L I AU - Abramson, J M AD - Department of Medicine, Veterans Affairs New York Harbor Health Care System, Brooklyn, USA. larry.lutwick@med.va.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 465 EP - 79, viii VL - 47 IS - 2 SN - 0031-3955, 0031-3955 KW - Viral Vaccines KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Plants, Genetically Modified KW - Immunotherapy KW - Humans KW - Hypersensitivity -- prevention & control KW - Forecasting KW - Child KW - Ixodes -- drug effects KW - Cocaine-Related Disorders -- prevention & control KW - Cocaine-Related Disorders -- immunology KW - Vaccination -- trends KW - Lyme Disease -- diagnosis KW - Lyme Disease -- prevention & control KW - Viral Vaccines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71031278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+clinics+of+North+America&rft.atitle=Pediatric+immunization+for+the+future.+Lyme+disease+vaccine+and+beyond.&rft.au=Lutwick%2C+L+I%3BAbramson%2C+J+M&rft.aulast=Lutwick&rft.aufirst=L&rft.date=2000-04-01&rft.volume=47&rft.issue=2&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Pediatric+clinics+of+North+America&rft.issn=00313955&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-26 N1 - Date created - 2000-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Therapeutic limit setting in an assertive community treatment program. AN - 71001770; 10737826 AB - The study examined the use of therapeutic limit-setting activities by members of assertive community treatment teams with clients who had serious mental illness. Case managers from 40 Veterans Affairs intensive psychiatric community care teams reported their use of 25 limit-setting activities with 1,564 veterans during the first six months of treatment. The 25-item measurement scale was factor analyzed, and a standard multiple regression procedure was used to regress scale scores on clients' characteristics, the frequency of case managers' contact with service providers and others, and clients' and case managers' perceptions about the therapeutic alliance. Case managers relied most frequently on informal verbal approaches to limit setting and relied least on formal legal restrictions. Factor analysis of the instrument, the Therapeutic Limit Setting (TLS) scale, reduced the number of items to 20 and resulted in a five-factor solution. The limit-setting factors were verbal guidance, money management, contingent withholding of services or support, enforced hospitalization, and invocation of external authorities. The TLS and its subscales were characterized by high internal consistency, modest intercorrelation, and unique relationships with variables related to clients' characteristics, the treatment process, and the therapeutic alliance. Case managers were more likely to set limits with clients who had more extensive hospitalization histories, a representative payee, recent alcohol or drug use, more arrests, and more severe symptoms. Case managers used a range of limit-setting strategies in assertive community treatment. Limit setting is a frequent and potentially important aspect of assertive community treatment that may be useful for comparing levels of assertiveness in assertive community treatment teams and other community-based rehabilitation services. JF - Psychiatric services (Washington, D.C.) AU - Neale, M S AU - Rosenheck, R A AD - Veterans Affairs Northeast Program Evaluation Center, VA Connecticut Healthcare System, Campbell Avenue, West Haven, Connecticut, 06156, USA. michael.neale@med.va.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 499 EP - 505 VL - 51 IS - 4 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - Patient Care Team KW - Humans KW - Treatment Outcome KW - Diagnosis, Dual (Psychiatry) KW - Social Support KW - Middle Aged KW - Case Management KW - Professional-Patient Relations KW - Male KW - Female KW - Substance-Related Disorders -- diagnosis KW - Psychotic Disorders -- psychology KW - Behavior Therapy KW - Veterans -- psychology KW - Psychotic Disorders -- rehabilitation KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Psychotic Disorders -- diagnosis KW - Community Mental Health Services KW - Assertiveness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71001770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Therapeutic+limit+setting+in+an+assertive+community+treatment+program.&rft.au=Neale%2C+M+S%3BRosenheck%2C+R+A&rft.aulast=Neale&rft.aufirst=M&rft.date=2000-04-01&rft.volume=51&rft.issue=4&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-27 N1 - Date created - 2000-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of ammonia on GABA uptake and release in cultured astrocytes. AN - 70987238; 10733006 AB - While the pathogenesis of hepatic encephalopathy (HE) is unclear, there is evidence of enhanced GABAergic neurotransmission in this condition. Ammonia is believed to play a major pathogenetic role in HE. To determine whether ammonia might contribute to abnormalities in GABAergic neurotransmission, its effects on GABA uptake and release were studied in cultured astrocytes, cells that appear to be targets of ammonia neurotoxicity. Acutely, ammonium chloride (5 mM) inhibited GABA uptake by 30%, and by 50-60% after 4-day treatment. GABA uptake inhibition was associated with a predominant decrease in Vmax; the Km was also decreased. Ammonia also enhanced GABA release after 4-day treatment, although such release was initially inhibited. These effects of ammonia (inhibition of GABA uptake and enhanced GABA release) may elevate extracellular levels of GABA and contribute to a dysfunction of GABAergic neurotransmission in HE and other hyperammonemic states. JF - Neurochemistry international AU - Bender, A S AU - Norenberg, M D AD - Veterans Administration Medical Center and Department of Pathology, University of Miami School of Medicine, FL 33101, USA. Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 389 EP - 395 VL - 36 IS - 4-5 SN - 0197-0186, 0197-0186 KW - GABA Antagonists KW - 0 KW - Ammonium Chloride KW - 01Q9PC255D KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Ammonia KW - 7664-41-7 KW - Index Medicus KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Kinetics KW - GABA Antagonists -- pharmacology KW - Ammonium Chloride -- pharmacology KW - Time Factors KW - Ammonia -- pharmacology KW - Astrocytes -- drug effects KW - gamma-Aminobutyric Acid -- metabolism KW - Astrocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70987238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=Effect+of+ammonia+on+GABA+uptake+and+release+in+cultured+astrocytes.&rft.au=Bender%2C+A+S%3BNorenberg%2C+M+D&rft.aulast=Bender&rft.aufirst=A&rft.date=2000-04-01&rft.volume=36&rft.issue=4-5&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=01970186&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-10 N1 - Date created - 2000-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of patient self-reports and urinalysis results obtained under naturalistic methadone treatment conditions. AN - 70956209; 10706974 AB - This study examined under naturalistic assessment conditions the validity of self-reported opiate and cocaine use among 175 veterans enrolled in methadone treatment, and factors related to self-report validity, such as stage in treatment and drug of abuse. Veterans were interviewed by clinical staff about past 30-day drug use with the addiction severity index (ASI), and urinalysis results were obtained for the same 30-day interval assessed with the ASI. Analysis revealed that urinalysis generally produced higher rates of substance use than patient self-report, and with the exception of reported opiate use among new patients presenting for treatment, validity of patient self-reported drug use generally was poor with patients under-reporting both opiate and cocaine use. The findings are in marked contrast to those obtained in other studies in which participants are ensured confidentiality regarding their self-reports. Further, the results raise questions about the utility of self-report measures of substance use to assess patient progress or methadone program performance. JF - Drug and alcohol dependence AU - Chermack, S T AU - Roll, J AU - Reilly, M AU - Davis, L AU - Kilaru, U AU - Grabowski, J AD - John D. Dingell VA Medical Center, Department of Psychiatry (116A), 4646 John R. Street, Detroit, MI 48201-1932, USA. chermack.stephen@med.va.gov Y1 - 2000/04/01/ PY - 2000 DA - 2000 Apr 01 SP - 43 EP - 49 VL - 59 IS - 1 SN - 0376-8716, 0376-8716 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Methadone -- therapeutic use KW - Reproducibility of Results KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Opioid-Related Disorders -- psychology KW - Patient Compliance -- psychology KW - Cocaine-Related Disorders -- psychology KW - Veterans -- psychology KW - Substance Abuse Detection -- psychology KW - Opioid-Related Disorders -- rehabilitation KW - Truth Disclosure KW - Cocaine-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70956209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Comparison+of+patient+self-reports+and+urinalysis+results+obtained+under+naturalistic+methadone+treatment+conditions.&rft.au=Chermack%2C+S+T%3BRoll%2C+J%3BReilly%2C+M%3BDavis%2C+L%3BKilaru%2C+U%3BGrabowski%2C+J&rft.aulast=Chermack&rft.aufirst=S&rft.date=2000-04-01&rft.volume=59&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-03 N1 - Date created - 2000-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Levofloxacin penetrates human monocytes and enhances intracellular killing of Staphylococcus aureus and Pseudomonas aeruginosa AN - 17562621; 4742266 AB - Intracellular bacteria often cause relapsing and refractory infections. However, these infections can be treated effectively with antibiotics such as ofloxacin which penetrate into the cells containing bacteria. As levofloxacin, the levorotatory isomer of ofloxacin, has enhanced antibacterial activity, we tested the levofloxacin concentration in human monocytes and the effects of intracellular levofloxacin on monocyte killing of Staphylococcus aureus strain ATCC 29213 and Pseudomonas aeruginosa strain PA1348A. Human monocytes were incubated with levofloxacin at various pH values and temperatures. Following incubation, the monocytes were separated from incubation media, and intracellular (C) and extracellular (E) levofloxacin concentrations were determined. Mean C/E ratios after 15 min of incubation with 6 and 12 mg/L levofloxacin at pH 7.4 were 6.4 and 7.1, respectively. C/E ratios were similar at pH 7.4 and 8.0, but decreased at lower pH values. To study the effects of levofloxacin on intracellular killing of S. aureus and P. aeruginosa, opsonized bacteria were added to monolayers of monocytes. Following phagocytosis, monocytes were incubated with various concentrations of levofloxacin, ciprofloxacin and rifampicin, alone or in combination. Levofloxacin (2.5 and 4 mg/L) significantly reduced the survival of cell-associated S. aureus and was more effective than ciprofloxacin at similar concentrations (P < 0.01). Enhanced killing of cell-associated P. aeruginosa by levofloxacin (0.5 and 1.0 mg/L) was also observed. Activities of levofloxacin and ciprofloxacin against cell-associated P. aeruginosa were similar. Addition of rifampicin did not augment the bactericidal activity of levofloxacin. Since levofloxacin is concentrated in human monocytes and increases their bactericidal activity against intracellular bacteria, it should be considered for treatment of infections caused by susceptible intracellular bacteria. JF - Journal of Antimicrobial Chemotherapy AU - Smith, R P AU - Baltch, AL AU - Franke, MA AU - Michelsen, P B AU - Bopp, L H AD - Infectious Disease Section, Stratton VA Medical Center, 113 Holland Avenue, Albany, NY 12208, USA, smith.raymond@albany.va.gov Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 483 EP - 488 VL - 45 IS - 4 SN - 0305-7453, 0305-7453 KW - intercellular killing KW - in vitro KW - man KW - levofloxacin KW - quinolones KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Monocytes KW - quinolines KW - Antibacterial agents KW - Pseudomonas aeruginosa KW - Staphylococcus aureus KW - J 02806:Quinones, quinolones and quinolines KW - A 01066:Antibacterial & bactericidal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17562621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Levofloxacin+penetrates+human+monocytes+and+enhances+intracellular+killing+of+Staphylococcus+aureus+and+Pseudomonas+aeruginosa&rft.au=Smith%2C+R+P%3BBaltch%2C+AL%3BFranke%2C+MA%3BMichelsen%2C+P+B%3BBopp%2C+L+H&rft.aulast=Smith&rft.aufirst=R&rft.date=2000-04-01&rft.volume=45&rft.issue=4&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Staphylococcus aureus; Pseudomonas aeruginosa; Antibacterial agents; quinolines; levofloxacin; Monocytes ER - TY - JOUR T1 - Effects of mutations in M4 of the gastric H+,K+-ATPase on inhibition kinetics of SCH28080. AN - 70986600; 10715120 AB - The effects of site-directed mutagenesis were used to explore the role of residues in M4 on the apparent Ki of a selective, K+-competitive inhibitor of the gastric H+,K+ ATPase, SCH28080. A double transfection expression system is described, utilizing HEK293 cells and separate plasmids encoding the alpha and beta subunits of the H+,K+-ATPase. The wild-type enzyme gave specific activity (micromoles of Pi per hour per milligram of expressed H+,K+-ATPase protein), apparent Km for ammonium (a K+ surrogate), and apparent Ki for SCH28080 equal to the H+, K+-ATPase purified from hog gastric mucosa. Amino acids in the M4 transmembrane segment of the alpha subunit were selected from, and substituted with, the nonconserved residues in M4 of the Na+, K+-ATPase, which is insensitive to SCH28080. Most of the mutations produced competent enzyme with similar Km,app values for NH4+ and Ki,app for SCH28080. SCH28080 affinity was decreased 2-fold in M330V and 9-fold in both M334I and V337I without significant effect on Km,app. Hence methionine 334 and valine 337 participate in binding but are not part of the NH4+ site. Methionine 330 may be at the periphery of the inhibitor site, which must have minimum dimensions of approximately 16 x 8 x 5 A and be accessible from the lumen in the E2-P conformation. Multiple sequence alignments place the membrane surface near arginine 328, suggesting that the side chains of methionine 334 and valine 337, on one side of the M4 helix, project into a binding cavity within the membrane domain. JF - Biochemistry AU - Munson, K B AU - Lambrecht, N AU - Sachs, G AD - Veterans' Administration Greater Los Angeles Healthcare System and Univeristy of California-Los Angeles Department of Medicine & Physiology, Los Angeles, California 90024, USA. Y1 - 2000/03/21/ PY - 2000 DA - 2000 Mar 21 SP - 2997 EP - 3004 VL - 39 IS - 11 SN - 0006-2960, 0006-2960 KW - Cations, Monovalent KW - 0 KW - Enzyme Inhibitors KW - Imidazoles KW - Proton Pump Inhibitors KW - Quaternary Ammonium Compounds KW - Sch 28080 KW - 00427X161I KW - H(+)-K(+)-Exchanging ATPase KW - EC 3.6.3.10 KW - Index Medicus KW - Animals KW - Cell Membrane -- enzymology KW - Cell Membrane -- drug effects KW - Humans KW - Cell Membrane -- genetics KW - Rabbits KW - Amino Acid Sequence KW - Cations, Monovalent -- metabolism KW - Enzyme Activation -- genetics KW - Blotting, Western KW - Kinetics KW - Binding Sites -- drug effects KW - Molecular Sequence Data KW - Enzyme Activation -- drug effects KW - Binding Sites -- genetics KW - Quaternary Ammonium Compounds -- pharmacology KW - Stomach -- enzymology KW - Cell Line KW - Mutagenesis, Site-Directed KW - Imidazoles -- metabolism KW - H(+)-K(+)-Exchanging ATPase -- metabolism KW - Enzyme Inhibitors -- chemistry KW - Enzyme Inhibitors -- metabolism KW - H(+)-K(+)-Exchanging ATPase -- chemistry KW - H(+)-K(+)-Exchanging ATPase -- genetics KW - Imidazoles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70986600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Effects+of+mutations+in+M4+of+the+gastric+H%2B%2CK%2B-ATPase+on+inhibition+kinetics+of+SCH28080.&rft.au=Munson%2C+K+B%3BLambrecht%2C+N%3BSachs%2C+G&rft.aulast=Munson&rft.aufirst=K&rft.date=2000-03-21&rft.volume=39&rft.issue=11&rft.spage=2997&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-14 N1 - Date created - 2000-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The human papillomavirus type 11 E1E4 protein is phosphorylated in genital epithelium. AN - 70954587; 10704351 AB - The most abundant viral transcript in human papillomavirus (HPV) 11-infected xenograft tissue has been shown to encode the E1(wedge)E4 protein. The function of E1(wedge)E4 protein has not been determined. Several potential phosphorylation sequence motifs were identified in the HPV 11 E1(wedge)E4 protein, including potential sites of phosphorylation by mitogen-activated protein kinase (MAPK), cAMP-dependent protein kinase (PKA), casein kinase II, and protein kinase C. To test phosphorylation of the HPV 11 E1(wedge)E4 protein, a soluble maltose binding protein (MBP) fusion was produced in Escherichia coli. Only MAPK and PKA phosphorylated the E1(wedge)E4 protein. Phosphoamino acid analysis showed that one or more threonine residues were phosphorylated by MAPK, and both serine and threonine residues were phosphorylated by PKA. MBP-E1(wedge)E4 mutant proteins were designed to delineate the E1(wedge)E4 phosphoacceptor residues. MAPK was shown to phosphorylate E1(wedge)E4 on threonine 53 within a MAPK consensus phorphorylation sequence motif. PKA was shown to phosphorylate E1(wedge)E4 at two residues: threonine 36 within a consensus motif and serine 44 within a variant of the PKA consensus phosphorylation sequence motif. HPV 11-infected human genital tissue grown as a xenograft in an athymic mouse was labeled with [(32)P]orthophosphate. Phosphoamino acid analysis of E1(wedge)E4 protein immunoprecipitated from (32)P-labeled tissue revealed that both serine and threonine residues were phosphorylated. Analysis by liquid chromatography-mass spectrophotometry was consistent with phosphorylation of residues within the PKA and MAPK phosphorylation sequence motifs. Expression of E1(wedge)E4 protein containing phosphorylation substitution mutations showed that the PKA mutant did not differ from wild-type E1(wedge)E4 protein in intracellular distribution. In contrast, the MAPK mutant did not localize exclusively to the cytoplasm nor did it colocalize with wild-type E1(wedge)E4 protein. We conclude that HPV 11 E1(wedge)E4 protein is phosphorylated in vitro and in vivo. Our data are consistent with phosph