TY - JOUR T1 - Prostate brachytherapy under local anesthesia; lessons from the first 600 patients. AN - 72914679; 15090277 AB - Local anesthesia for prostate brachytherapy was instituted at the Puget Sound Veterans Hospital in 1999, peforming the procedure in our own department without anesthesia personnel in attendance. The patient is brought into the simulator suite in the radiation oncology department, an i.v. line is started, a cardiac monitor attached, and a urinary catheter is inserted. He is then placed in the lithotomy position, using stirrups attached to the simulator table. A 6-8 cm patch of perineal skin and subcutaneous tissue is anesthetized by local infiltration of 1% lidocaine. The transrectal ultrasound (TRUS) probe is then inserted and positioned to reproduce the planning images. A 3.0 inch 22-gauge spinal needle is used to inject lidocaine up to the prostatic apex, in a pattern around the periphery of the prostate. Once the pelvic floor and prostatic apex are anesthetized, a 7.0-inch, 22-gauge spinal needle is inserted through an 18-gauge 3 inch spinal needle into the peripheral planned needle tracks, monitored by TRUS. As the needles are advanced to the prostatic base, about 1.0 cc of lidocaine solution is injected in the intraprostatic track. A total of 200 to 500 mg of lidocaine is used. As of December 2000, more than 600 patients have received implants under local anesthesia at Seattle, WA. Patients tolerate brachytherapy under local anesthesia surprisingly well. Post-implant CT-defined target coverage has ranged from 80% to 95%, well within published criteria for technical adequacy. Patients' typical implant pain score is 3, on a scale of 0-10. After a series of patient acceptance quality studies, we have abandoned the routine use of sedation, and relied instead on local lidocaine infiltration alone. In addition to a high degree of patient satisfaction, performing implants under local anesthesia allows for phenomenal logistical efficiencies and cost advantages. JF - Brachytherapy AU - Wallner, Kent AD - Radiation Oncology, Puget Sound Health Care System, Department of Veterans Affairs, Seattle, WA, USA. kent.wallner@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 145 EP - 148 VL - 1 IS - 3 SN - 1538-4721, 1538-4721 KW - Anesthetics, Local KW - 0 KW - Lidocaine KW - 98PI200987 KW - Index Medicus KW - Lidocaine -- administration & dosage KW - Anesthetics, Local -- administration & dosage KW - Patient Satisfaction KW - Prostate -- diagnostic imaging KW - Humans KW - Prostate -- pathology KW - Pain KW - Ultrasonography KW - Male KW - Brachytherapy -- adverse effects KW - Brachytherapy -- methods KW - Anesthesia, Local -- methods KW - Prostatic Neoplasms -- radiotherapy KW - Prostatic Neoplasms -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72914679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brachytherapy&rft.atitle=Prostate+brachytherapy+under+local+anesthesia%3B+lessons+from+the+first+600+patients.&rft.au=Wallner%2C+Kent&rft.aulast=Wallner&rft.aufirst=Kent&rft.date=2002-01-01&rft.volume=1&rft.issue=3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Brachytherapy&rft.issn=15384721&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-05 N1 - Date created - 2004-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Alcohol Use Disorders Identification Test (AUDIT) predicts alcohol withdrawal symptoms during inpatient detoxification. AN - 72123861; 12296504 AB - We evaluated whether the Alcohol Use Disorders Identification Test (AUDIT) predicted clinically meaningful alcohol withdrawal syndrome (AWS) in 118 alcohol dependent patients without a history of seizures. Patients were monitored by serial administration of the revised Clinical Institute Withdrawal Assessment Scale for Alcohol (CIWA-Ar) during inpatient detoxification. Patients (N = 55) who reached threshold level of AWS for receiving medication (CIWA-Ar > 9) scored significantly higher (p <.001) on the AUDIT total score, the dependence sub-scale, and the single item on morning drinking. Sensitivity, specificity, positive and negative predictive power, and screening efficiency showed the value of the AUDIT for identifying patients who developed AWS. The AUDIT should be explored alone and in combination with other parameters to improve screening for clinically meaningful AWS in other settings. JF - Journal of addictive diseases AU - Reoux, Joseph P AU - Malte, Carol A AU - Kivlahan, Daniel R AU - Saxon, Andrew J AD - Veterans Affairs Puget Sound Health Care System, Addictions Treatment Center, Seattle, WA 98108, USA. joe.reoux@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 81 EP - 91 VL - 21 IS - 4 SN - 1055-0887, 1055-0887 KW - Anti-Anxiety Agents KW - 0 KW - Benzodiazepines KW - 12794-10-4 KW - Index Medicus KW - Sensitivity and Specificity KW - Psychiatric Status Rating Scales KW - Hospitalization KW - Humans KW - Surveys and Questionnaires KW - Anti-Anxiety Agents -- therapeutic use KW - Predictive Value of Tests KW - Middle Aged KW - Male KW - Female KW - Alcoholism -- diagnosis KW - Alcohol Withdrawal Seizures -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72123861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+addictive+diseases&rft.atitle=The+Alcohol+Use+Disorders+Identification+Test+%28AUDIT%29+predicts+alcohol+withdrawal+symptoms+during+inpatient+detoxification.&rft.au=Reoux%2C+Joseph+P%3BMalte%2C+Carol+A%3BKivlahan%2C+Daniel+R%3BSaxon%2C+Andrew+J&rft.aulast=Reoux&rft.aufirst=Joseph&rft.date=2002-01-01&rft.volume=21&rft.issue=4&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Journal+of+addictive+diseases&rft.issn=10550887&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-02-26 N1 - Date created - 2002-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of aging on cardiac contractility in a rat model of chronic daunorubicin cardiotoxicity. AN - 72118830; 12271153 AB - Because the risk of chronic anthracycline cardiotoxicity increases with age, the effect of chronic daunorubicin was compared in young (6-9 mo) and senescent (24-26 mo) Fischer 344 rats in cumulative doses of 12 or 18 mg/kg. Senescent rats treated using 18 mg/kg of daunorubicin did not survive because of daunorubicin toxicity. Rats were euthanized 1 wk after the last dose of daunorubicin and ex vivo studies of isometric cardiac contractile function were done in left ventricular trabeculae carneae. In senescent rats given 12 mg/kg of daunorubicin, it caused significant impairment of contractility (dS/dt at 15 cpm; p = 0.001) that was not observed in either young adult group. In addition, the effect of 12 mg/kg of daunorubicin on contractility in senescent rats was significantly reduced compared to that in young rats administered 12 mg/kg of daunorubicin (p < 0.001), although the effect was similar to that in young rats given 18 mg/kg of daunorubicin. In rats receiving 12 mg/kg of daunorubicin, there was an age-dependent effect of daunorubicin on rate-related contractility and on Ca2+-induced contractility. Daunorubicinol, but not daunorubicin, concentrations were increased in the senescent rat heart tissue. This suggests that chronic daunorubicin cardiotoxicity increases with age, at least partly resulting from sarcoplasmic reticulum dysfunction caused by increased anthracycline exposure. JF - Cardiovascular toxicology AU - Cusack, Barry J AU - Young, Stephen P AU - Gabliel, Hervé AU - Olson, Richard D AD - Clinical Pharmacology and Gerontology Research Unit, Veterans Affairs Medical Center, Boise, ID 83702, USA. barry.cusack@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 99 EP - 109 VL - 2 IS - 2 SN - 1530-7905, 1530-7905 KW - Antibiotics, Antineoplastic KW - 0 KW - Calcium Channels KW - Triglycerides KW - Cholesterol KW - 97C5T2UQ7J KW - Creatinine KW - AYI8EX34EU KW - Daunorubicin KW - ZS7284E0ZP KW - Index Medicus KW - Ventricular Function, Left -- drug effects KW - Triglycerides -- blood KW - Animals KW - Dose-Response Relationship, Drug KW - Heart Diseases -- chemically induced KW - Heart Ventricles -- metabolism KW - Disease Models, Animal KW - Creatinine -- blood KW - Myocardium -- metabolism KW - Depression, Chemical KW - Rats KW - Models, Cardiovascular KW - Cholesterol -- blood KW - Rats, Inbred F344 KW - Sarcoplasmic Reticulum -- metabolism KW - Sarcoplasmic Reticulum -- drug effects KW - Calcium Channels -- drug effects KW - Heart Ventricles -- drug effects KW - Chronic Disease KW - Time Factors KW - Male KW - Daunorubicin -- pharmacology KW - Aging -- physiology KW - Antibiotics, Antineoplastic -- pharmacology KW - Daunorubicin -- adverse effects KW - Myocardial Contraction -- drug effects KW - Aging -- blood KW - Antibiotics, Antineoplastic -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72118830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cardiovascular+toxicology&rft.atitle=Effect+of+aging+on+cardiac+contractility+in+a+rat+model+of+chronic+daunorubicin+cardiotoxicity.&rft.au=Cusack%2C+Barry+J%3BYoung%2C+Stephen+P%3BGabliel%2C+Herv%C3%A9%3BOlson%2C+Richard+D&rft.aulast=Cusack&rft.aufirst=Barry&rft.date=2002-01-01&rft.volume=2&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Cardiovascular+toxicology&rft.issn=15307905&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-05 N1 - Date created - 2002-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - pH-dependent oxidant production following inhibition of the mitochondrial electron transport chain in pulmonary endothelial cells. AN - 72041098; 12200958 AB - We investigated the effect of changes in intracellular pH (pHi) and Na/H antiport activity on intracellular oxidant production in human pulmonary artery endothelial cells (HPAEC) following disruption of cellular metabolism. Oxidant production was measured with oxidant-sensitive probes (2',7'-dichlorofluorescein diacetate [H2DCF], dihydroethidium [DHE]) following treatment with inhibitors of mitochondrial electron transport and glycolysis (antimycin/2-deoxyglucose, A/D). A/D treatment increased oxidant production in a dose-dependent fashion over 2 hours. Omission of 2-deoxyglucose did not alter the magnitude of oxidant production. Inhibition at more proximal sites in the mitochondrial electron transport chain inhibited oxidant production. These data suggested that the mitochondrial electron transport chain was the source of oxidant production. Fluorescent imaging experiments confirmed the mitochondrial origin of the increased oxidant production under these conditions. Maneuvers that reduced pHi and inhibited Na/H exchange (acidosis, specific Na/H exchange inhibitors) attenuated oxidant production, whereas maneuvers that raised pHi (monensin) potentiated oxidant production. The results with the pH-insensitive probe (DHE) confirmed that oxidant production was pH-dependent. Oxidant production preceded significant loss of cell viability at 6 h following A/D treatment. These results demonstrate that oxidant production following inhibition of mitochondrial electron transport in HPAEC is pH-dependent and may contribute to endothelial cell injury by increasing endogenous oxidative stress. JF - Endothelium : journal of endothelial cell research AU - Cutaia, M AU - Kroczynski, J AU - Tollefson, K AD - Pulmonary Disease Division, University of Pennsylvania School of Medicine, VA Medical Center, Philadelphia, Pennsylvania, USA. michael.cutaia@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 109 EP - 121 VL - 9 IS - 2 SN - 1062-3329, 1062-3329 KW - Fluorescent Dyes KW - 0 KW - Oxidants KW - Sodium-Hydrogen Antiporter KW - antimycin KW - 11118-72-2 KW - Antimycin A KW - 642-15-9 KW - Deoxyglucose KW - 9G2MP84A8W KW - Index Medicus KW - Glycolysis -- drug effects KW - Cell Survival -- drug effects KW - Sodium-Hydrogen Antiporter -- metabolism KW - Cells, Cultured KW - Hydrogen-Ion Concentration KW - Humans KW - Mitochondria -- drug effects KW - Mitochondria -- metabolism KW - Sodium-Hydrogen Antiporter -- antagonists & inhibitors KW - Deoxyglucose -- pharmacology KW - Antimycin A -- pharmacology KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Endothelium, Vascular -- cytology KW - Antimycin A -- analogs & derivatives KW - Oxidants -- metabolism KW - Electron Transport -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72041098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endothelium+%3A+journal+of+endothelial+cell+research&rft.atitle=pH-dependent+oxidant+production+following+inhibition+of+the+mitochondrial+electron+transport+chain+in+pulmonary+endothelial+cells.&rft.au=Cutaia%2C+M%3BKroczynski%2C+J%3BTollefson%2C+K&rft.aulast=Cutaia&rft.aufirst=M&rft.date=2002-01-01&rft.volume=9&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Endothelium+%3A+journal+of+endothelial+cell+research&rft.issn=10623329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-24 N1 - Date created - 2002-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Management of systemic candidal infections in the intensive care unit. AN - 71415340; 11813465 AB - Risk factors and treatment strategies for systemic candidal infections in the intensive care unit (ICU) are discussed. The past two decades have seen a dramatic increase in the frequency of infections caused by Candida species. Risk factors associated with candidemia include treatment with multiple antimicrobials for extended periods, presence of central venous catheters, total parenteral nutrition, colonization by Candida species, abdominal surgery, prolonged stay in the ICU, and compromised immune status. Since the 1960s, conventional amphotericin B has been the primary treatment option for fungal infections. Although effective, amphotericin B has extensive toxicity. Three lipid-based formulations of amphotericin B have been developed in an attempt to decrease nephrotoxicity and improve drug delivery. Practitioners have also been offered alternatives by the introduction of less toxic azole antifungals, such as ketoconazole, fluconazole, and itraconazole; however, their widespread use has resulted in other problems, such as the selection of resistant isolates. There is controversy concerning fluconazole's effectiveness. In the treatment of systemic candidal infections, especially in critically ill patients. Clinical trials do not support the prophylactic or empirical use of fluconazole in the ICU. Treating patients who have no microbiological evidence of infection provides no therapeutic benefit and shifts the fungal flora to noncandidal strains that are more resistant to fluconazole. Patients in ICUs are often susceptible to systemic candidal infection. Preemptive therapy with fluconazole may reduce mortality in high-risk patients. Fluconazole and amphotericin B appear equally effective in treating established systemic candidal infections. JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Kam, Linda W AU - Lin, Jason D AD - James A. Haley Veterans Affairs Medical Center, Pharmacy Department (119), 13000 Bruce B. Downs Boulevard, Tampa, FL 33612, USA. linda.kam@med.va.gov Y1 - 2002/01/01/ PY - 2002 DA - 2002 Jan 01 SP - 33 EP - 41 VL - 59 IS - 1 SN - 1079-2082, 1079-2082 KW - Antifungal Agents KW - 0 KW - Amphotericin B KW - 7XU7A7DROE KW - Fluconazole KW - 8VZV102JFY KW - Index Medicus KW - Risk Factors KW - Humans KW - Cross Infection -- etiology KW - Drug Resistance, Microbial KW - Cross Infection -- epidemiology KW - Cross Infection -- drug therapy KW - Antibiotic Prophylaxis KW - Candidiasis -- drug therapy KW - Candidiasis -- epidemiology KW - Fluconazole -- therapeutic use KW - Intensive Care Units KW - Candidiasis -- etiology KW - Amphotericin B -- therapeutic use KW - Antifungal Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71415340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Management+of+systemic+candidal+infections+in+the+intensive+care+unit.&rft.au=Kam%2C+Linda+W%3BLin%2C+Jason+D&rft.aulast=Kam&rft.aufirst=Linda&rft.date=2002-01-01&rft.volume=59&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-24 N1 - Date created - 2002-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ang II accumulation in rat renal endosomes during Ang II-induced hypertension: role of AT(1) receptor. AN - 71400065; 11799089 AB - Hypertension induced by long-term infusion of angiotensin II (Ang II) is associated with augmented intrarenal Ang II levels to a greater extent than can be explained on the basis of the circulating Ang II levels. Although part of this augmentation is due to AT(1) receptor-dependent internalization, the intracellular compartments involved in this Ang II accumulation remain unknown. In the present study, we sought to determine whether Ang II trafficking into renal cortical endosomes is increased during Ang II hypertension, and if so, whether the AT(1) receptor antagonist, candesartan, prevents this accumulation. Compared with controls (n=12; 114+/-2 mm Hg), Ang II-infused rats (n=12; 80 ng/kg/min, SC, for 13 days) developed hypertension with systolic blood pressure rising to 185+/-4 mm Hg by Day 12. In Ang II hypertensive rats, plasma renin activity was suppressed, whereas plasma and kidney Ang II levels were increased by 3-fold (348+/-58 versus 119+/-16 fmol/mL) and 2-fold (399+/-39 versus 186+/-26 fmol/g). Intracellular endosomal Ang II levels were increased by more than 10-fold (1100+/-283 versus 71+/-12 fmol/mg protein), whereas intermicrovillar cleft Ang II levels were increased by more than 2-fold (88+/-22 versus 37+/-7 fmol/mg protein). Flow cytometric analysis detected significant increases in AT(1A) receptor antibody binding in endosomal and intermicrovillar clefts of Ang II-infused rats. The hypertension induced by Ang II was prevented in rats treated concurrently with candesartan (2 mg/kg/d, 119+/-3 mm Hg). Candesartan treatment (n=8) also prevented increases in kidney (215+/-19 fmol/g), endosomal (96+/-29 fmol/mg protein), and intermicrovillar cleft Ang II levels (11+/-2 fmol/mg protein). These results indicate that there is substantial intracellular accumulation of angiotensin peptides in renal cortical endosomes during Ang II-dependent hypertension via an AT(1) receptor-mediated process. JF - Hypertension (Dallas, Tex. : 1979) AU - Zhuo, Jia L AU - Imig, John D AU - Hammond, Timothy G AU - Orengo, Sheyla AU - Benes, Edmund AU - Navar, L Gabriel AD - Department of Physiology, Tulane University School of Medicine, Veterans Administration Medical Center , New Orleans, Louisiana 70112, USA. Y1 - 2002/01// PY - 2002 DA - January 2002 SP - 116 EP - 121 VL - 39 IS - 1 KW - Angiotensin Receptor Antagonists KW - 0 KW - Antibodies KW - Antihypertensive Agents KW - Benzimidazoles KW - Dextrans KW - Fluoresceins KW - Receptor, Angiotensin, Type 1 KW - Receptors, Angiotensin KW - Tetrazoles KW - fluorescein-dextran KW - Angiotensin II KW - 11128-99-7 KW - Angiotensin I KW - 9041-90-1 KW - Renin KW - EC 3.4.23.15 KW - candesartan KW - S8Q36MD2XX KW - Index Medicus KW - Animals KW - Angiotensin I -- blood KW - Benzimidazoles -- pharmacology KW - Microvilli -- metabolism KW - Fluoresceins -- pharmacokinetics KW - Antihypertensive Agents -- pharmacology KW - Renin -- blood KW - Rats KW - Tetrazoles -- pharmacology KW - Rats, Sprague-Dawley KW - Antibodies -- metabolism KW - Dextrans -- pharmacokinetics KW - Systole -- drug effects KW - Flow Cytometry KW - Blood Pressure -- drug effects KW - Male KW - Receptors, Angiotensin -- immunology KW - Angiotensin II -- blood KW - Kidney -- metabolism KW - Hypertension -- chemically induced KW - Receptors, Angiotensin -- metabolism KW - Kidney -- drug effects KW - Kidney -- ultrastructure KW - Endosomes -- metabolism KW - Angiotensin II -- pharmacokinetics KW - Hypertension -- metabolism KW - Angiotensin II -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71400065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Ang+II+accumulation+in+rat+renal+endosomes+during+Ang+II-induced+hypertension%3A+role+of+AT%281%29+receptor.&rft.au=Zhuo%2C+Jia+L%3BImig%2C+John+D%3BHammond%2C+Timothy+G%3BOrengo%2C+Sheyla%3BBenes%2C+Edmund%3BNavar%2C+L+Gabriel&rft.aulast=Zhuo&rft.aufirst=Jia&rft.date=2002-01-01&rft.volume=39&rft.issue=1&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=1524-4563&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-20 N1 - Date created - 2002-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transient neurological symptoms after subarachnoid meperidine. AN - 71386594; 11772831 AB - The syndrome of transient neurological symptoms (TNS) after subarachnoid use of local anesthetics, particularly lidocaine, has been well described. This syndrome has not been reported with the subarachnoid use of opioids. This case report describes TNS that occurred after administration of subarachnoid meperidine, an opioid with local anesthetic properties. JF - Anesthesia and analgesia AU - Lewis, Wilfred R AU - Perrino, Albert C AD - Department of Anesthesiology, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA. Wilfred.Lewis@med.va.gov Y1 - 2002/01// PY - 2002 DA - January 2002 SP - 213 EP - 4, table of contents VL - 94 IS - 1 SN - 0003-2999, 0003-2999 KW - Analgesics, Opioid KW - 0 KW - Meperidine KW - 9E338QE28F KW - Abridged Index Medicus KW - Index Medicus KW - Subarachnoid Space KW - Humans KW - Aged KW - Male KW - Pain -- etiology KW - Meperidine -- adverse effects KW - Anesthesia, Spinal -- adverse effects KW - Meperidine -- administration & dosage KW - Analgesics, Opioid -- adverse effects KW - Analgesics, Opioid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71386594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Transient+neurological+symptoms+after+subarachnoid+meperidine.&rft.au=Lewis%2C+Wilfred+R%3BPerrino%2C+Albert+C&rft.aulast=Lewis&rft.aufirst=Wilfred&rft.date=2002-01-01&rft.volume=94&rft.issue=1&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=00032999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-25 N1 - Date created - 2002-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Technical Skill and the Therapeutic Relationship: A Fundamental Dilemma in Cognitive-Behavioral and Insight-Oriented Therapy AN - 61493941; 200300313 AB - Perceived role conflicts that cognitive-behavioral therapists share with insight-oriented therapists in balancing the use of clinical techniques & attention to the therapeutic relationship are discussed. Clinical dilemmas that have arisen in traditional forms of insight-oriented treatment are examined in light of cognitive-behavior therapy. These dilemmas include (1) the necessary balance between technical interventions & maintenance of the therapeutic relationship, (2) the spontaneous, moment-to-moment patient-therapist interactions which constitute clinical judgment, (3) the notion of countertransference in the practice of cognitive-behavior therapy, (4) the treatment of historical/developmental influences upon behavior vs more contemporaneous influences, & (5) the manner in which cognitive-behavioral & the directive aspects of therapy borrow from the nurturant function of the psychotherapist. The multidimensional factors of clinical training that constitute the protracted role functions for the cognitive-behavior therapist are outlined. 101 References. Adapted from the source document. JF - Family Therapy AU - Scaturo, Douglas J AD - Behavioral Health Outpatient Clinic, Dept Veterans Affairs, Syracuse VA Medical Center, NY douglas.scaturo@med.va.gov Y1 - 2002///0, PY - 2002 DA - 0, 2002 SP - 1 EP - 21 VL - 29 IS - 1 SN - 0091-6544, 0091-6544 KW - Therapists KW - Transference (Psychology) KW - Client Relations KW - Psychotherapy KW - Role Conflict KW - Treatment Methods KW - article KW - 6121: therapeutic interventions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61493941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Family+Therapy&rft.atitle=Technical+Skill+and+the+Therapeutic+Relationship%3A+A+Fundamental+Dilemma+in+Cognitive-Behavioral+and+Insight-Oriented+Therapy&rft.au=Scaturo%2C+Douglas+J&rft.aulast=Scaturo&rft.aufirst=Douglas&rft.date=2002-01-01&rft.volume=29&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Family+Therapy&rft.issn=00916544&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Treatment Methods; Client Relations; Transference (Psychology); Psychotherapy; Therapists; Role Conflict ER - TY - JOUR T1 - Epidemiological and Clinical Aspects of Nonsteroidal Anti-inflammatory Drugs and Cancer Risks AN - 18431518; 5412234 AB - It is well known that about 70% of cancer cases are due to environmental, dietary, or lifestyle factors. Accordingly, these cases may be avoided by appropriate modifications. In addition, active chemoprevention has become a major interventional approach following the epidemiological observation of a beneficial effect of nonsteroidal anti-inflammatory drugs (NSAIDs) in colon cancer prevention. This is chiefly due to the inhibition of the cyclooxygenase (COX) enzymes. The COX enzymatic system includes two isoenzymes, COX-1 and COX-2, that convert arachidonic acid to prostaglandins. COX-1 is constitutively expressed and synthesizes cytoprotective prostaglandins in the gastrointestinal tract. COX-2 is inducible by the oncogenes ras and scr and other cytokines; it is overexpressed in human cancer cells in which it stimulates cellular division and angiogenesis and inhibits apoptosis. NSAIDs restore apoptosis and decrease tumor mitogenesis and angiogenesis. Most cancer cells have been found to exhibit overexpression of COX-2. Epidemiological studies showed a lower risk of developing cancer of the colon, breast, esophagus, and stomach following the ingestion of NSAIDs. The use of NSAIDs in low dose was associated with a statistically significant decrease in the risk of adenomatous polyps and of overt colon cancer. The regressive effects of sulindac on foci of aberrant crypts in the colon (considered to be precursors of adenoma), and on adenocarcinoma of the colon, are of particular interest because this NSAID does not have an inhibitory effect on COX. This may support the view that the antineoplastic effect of NSAIDs may also be due to a mechanism other than COX-2 inhibition. In breast cancer, large cohort studies reported a 40 to 50% reduced risk of developing cancer, a smaller size of the primary tumor, and a reduction in the number of involved axillary lymph nodes. Similar findings have been reported in the esophagus and stomach, but not in gastric cardia adenocarcinoma. The recent development of selective COX-2 inhibitors resulted in better clinical tolerance than that associated with NSAIDs in general, with the absence of gastrointestinal side effects known to occur after the inhibition of COX-1. Encouraging results have been obtained with these new agents in familial adenomatous polyposis, colon, breast, and prostate cancer. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Moran, E M AD - Cancer Program (11-T), V.A. Medical Center, 5901 East Seventh Street, Long Beach, CA 90822, USA, edgar.moran@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 193 EP - 202 VL - 21 IS - 2 SN - 0731-8898, 0731-8898 KW - chemoprevention KW - epidemiology KW - man KW - Toxicology Abstracts KW - X 24250:Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18431518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Epidemiological+and+Clinical+Aspects+of+Nonsteroidal+Anti-inflammatory+Drugs+and+Cancer+Risks&rft.au=Moran%2C+E+M&rft.aulast=Moran&rft.aufirst=E&rft.date=2002-01-01&rft.volume=21&rft.issue=2&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Association between initial empirical therapy and decreased length of stay among veteran patients hospitalized with community acquired pneumonia AN - 18371462; 5348264 AB - This investigation assessed the impact of initial empirical antimicrobial therapy on the outcome of therapy for community acquired pneumonia (CAP) patients and on patients' length of stay (LOS) in the hospital. Hospital records for 165 patients with pneumonia admitted to the Edward Hines, Jr. VA Hospital between 1 October 1997, and 31 March 2000, were reviewed. Criteria for CAP were met for 92 of 165 patients. Comparisons were made between patients treated with azithromycin and with other parenteral antibiotics (the reference group). No statistical differences were observed between the treatment groups for the risk factors. The azithromycin group patients were slightly older with a mean age of 69 years versus 66 years (P = 0.23). Patients treated with parenteral azithromycin had on average, a shorter length of hospitalization namely 4.6 days compared with 9.7 days for patients treated with the other antibiotics (log-rank test, P = 0.0001). In order to make the two groups of patients more alike we considered patients' data set without intensive care unit (ICU) admissions. The conclusion was the same namely azithromycin monotherapy was associated with a decreased duration of hospital stay. JF - International Journal of Antimicrobial Agents AU - Lentino, J R AU - Krasnicka, B AD - Section of Infectious Diseases (111P), Medical Service, Cooperative Studies Program Coordinating Center, Edward Hines, Jr. VA Hospital, Hines, IL 60141, USA, joseph.lentino@med.va.gov Y1 - 2002/01// PY - 2002 DA - Jan 2002 SP - 61 EP - 66 VL - 19 IS - 1 SN - 0924-8579, 0924-8579 KW - azithromycin KW - Microbiology Abstracts B: Bacteriology KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18371462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Antimicrobial+Agents&rft.atitle=Association+between+initial+empirical+therapy+and+decreased+length+of+stay+among+veteran+patients+hospitalized+with+community+acquired+pneumonia&rft.au=Lentino%2C+J+R%3BKrasnicka%2C+B&rft.aulast=Lentino&rft.aufirst=J&rft.date=2002-01-01&rft.volume=19&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Antimicrobial+Agents&rft.issn=09248579&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Neuromuscular blockers in surgery and intensive care, Part 2. AN - 72411813; 11794954 AB - The historical development, pharmacology, pharmacodynamics, pharmacokinetics, clinical applications, pharmacologic basis for selection, adverse effects, and cost of neuromuscular blockers (NMBs) are discussed. The first NMB to be used was tubocurarine. During neurotransmission, acetylcholine is synthesized, stored in vesicles at the neuromuscular junction, released into the synapse, and bound to nicotinic receptors in the muscle end plate. For muscle contraction to occur, the impulse generated in a neuron's cell body must create an action potential that is chemically transmitted across the synapse. The postsynaptic nicotinic receptor at the neuromuscular junction is the major site of action of depolarizing and nondepolarizing NMBs. All NMBs have the potential for cross-reactivity at other nicotinic and muscarinic sites. Drug interactions most commonly occur between NMBs and inhalation anesthetics, certain antimicrobials, calcium-channel blockers, and anticholinesterases. When selecting an NMB, an agent's onset and duration of action must be considered. NMBs can be used on a short-term or long-term basis. Apart from cost, the choice of an NMB is made on the basis of its adverse-reaction profile, pharmacokinetics, and indications for use. Monitoring tools, their use, the rationale for their use, and the interpretation of the results they provide are unique. The patterns of peripheral nerve stimulation vary and elicit different characteristics of nondepolarizing neuromuscular blockade. The effectiveness of reversal agents is proportional to the degree of blockade. The mechanism of action of anticholinesterases involves inhibition of acetylcholinesterase. The expensive NMBs should be conserved for use in surgery, while the cheaper, long-acting [corrected] agents should be used in the intensive care unit. An understanding of the pharmacology, pharmacodynamics, and pharmacokinetics of NMBs will help health care providers gain expertise in the selection and use of these agents. JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - McManus, M C AD - School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, MA, USA. mcmanus.claire@boston.va.gov Y1 - 2001/12/15/ PY - 2001 DA - 2001 Dec 15 SP - 2381 EP - 2395 VL - 58 IS - 24 SN - 1079-2082, 1079-2082 KW - Cholinesterase Reactivators KW - 0 KW - Neuromuscular Blocking Agents KW - Neuromuscular Nondepolarizing Agents KW - Receptors, Drug KW - Succinylcholine KW - J2R869A8YF KW - Index Medicus KW - Humans KW - Neuromuscular Nondepolarizing Agents -- metabolism KW - Succinylcholine -- pharmacology KW - Monitoring, Physiologic KW - Succinylcholine -- metabolism KW - Succinylcholine -- therapeutic use KW - Succinylcholine -- adverse effects KW - Receptors, Drug -- metabolism KW - Neuromuscular Nondepolarizing Agents -- therapeutic use KW - Critical Illness KW - Cholinesterase Reactivators -- therapeutic use KW - Neuromuscular Nondepolarizing Agents -- pharmacology KW - Neuromuscular Nondepolarizing Agents -- adverse effects KW - Neuromuscular Blocking Agents -- adverse effects KW - Anesthesia KW - Neuromuscular Blocking Agents -- therapeutic use KW - Neuromuscular Blocking Agents -- metabolism KW - Critical Care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72411813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Neuromuscular+blockers+in+surgery+and+intensive+care%2C+Part+2.&rft.au=McManus%2C+M+C&rft.aulast=McManus&rft.aufirst=M&rft.date=2001-12-15&rft.volume=58&rft.issue=24&rft.spage=2381&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-12 N1 - Date created - 2002-01-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Am J Health Syst Pharm 2002 Jan 1;59(1):16 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential Regulation of Mouse Kidney Sodium-Dependent Transporters mRNA by Cadmium AN - 18226933; 5295265 AB - Chronic exposure to cadmium can result in renal glycosuria. Previously, we reported that cadmium reduced the relative abundance of the sodium-glucose cotransporter mRNA (Blumenthal et al., Toxicol. Appl. Pharmacol.149, 49-54, 1998). To investigate this phenomenon further, we isolated full-length cDNA clones encoding both high- and low-affinity sodium-dependent glucose transporters SGLT1 and SGLT2, respectively, from cultured mouse kidney cortical cells. We also amplified a fragment of another putative sodium-glucose cotransporter with homology to the known SAAT1 /pSGLT2 or SGLT3 from our cultured cells and named it SGLT3. In order to examine the effect of cadmium on these transporters, primary cultures of mouse kidney cortical cells were exposed to micromolar concentrations of cadmium for 24 h and levels of SGLT1, SGLT2, and SGLT3 mRNA were determined by semiquantitative RT-PCR. Five to 10 mu M of cadmium inhibited sodium-dependent uptake of the glucose analog, alpha -methyl -glucopyranoside and progressively reduced the level of SGLT1. Cadmium also inhibited SGLT2 mRNA by 37%, but no further decline was observed at concentrations of cadmium greater than 5 mu M. While cadmium inhibited SGLT1 and SGLT2, it significantly stimulated the expression of SGLT3 by fivefold. These results imply that individual sodium-glucose cotransporter mRNA species are not regulated in a similar fashion. In addition, the isolation of three separate SGLT species from these cultures suggests that, in addition to SGLT1 and SGLT2, glucose reabsorption by renal epithelial cells might involve additional glucose transporters such as SGLT3. [copy ]2001 Elsevier Science. JF - Toxicology and Applied Pharmacology AU - Tabatabai, N M AU - Blumenthal, S S AU - Lewand, D L AU - Petering, D H AD - Department of Medicine, Medical College of Wisconsin, Section of Nephrology/111K, Zablocki Veterans Administration Medical Center, 5000 West National Avenue, Milwaukee, Wisconsin, 53295, ssblumen@mcw.edu Y1 - 2001/12/15/ PY - 2001 DA - 2001 Dec 15 SP - 163 EP - 173 PB - Academic Press VL - 177 IS - 3 SN - 0041-008X, 0041-008X KW - chronic toxicity KW - SGLT1 protein KW - SGLT2 protein KW - SGLT3 protein KW - glucose transport KW - sodium transport KW - Toxicology Abstracts KW - Kidney KW - Cadmium KW - mRNA KW - X 24162:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18226933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Differential+Regulation+of+Mouse+Kidney+Sodium-Dependent+Transporters+mRNA+by+Cadmium&rft.au=Tabatabai%2C+N+M%3BBlumenthal%2C+S+S%3BLewand%2C+D+L%3BPetering%2C+D+H&rft.aulast=Tabatabai&rft.aufirst=N&rft.date=2001-12-15&rft.volume=177&rft.issue=3&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1006%2Ftaap.2001.9321 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - mRNA; Kidney; Cadmium DO - http://dx.doi.org/10.1006/taap.2001.9321 ER - TY - JOUR T1 - Chlamydia pneumoniae and Chronic Skin Wounds: A Focused Review AN - 907161550; 14934895 AB - The genus, Chlamydophilia, as obligate intracellular pathogens, induce chronic scarring in humans. Chlamydia pneumoniae, a common cause of pneumonia, infects endothelial cells and circulating macrophages. Evidence that C. pneumoniae is an opportunistic pathogen in chronic skin ulcers and other inflammatory skin conditions analogous to its role in atherosclerosis is reviewed.Journal of Investigative Dermatology Symposium Proceedings (2001) 6, 233-237; doi:10.1046/j.0022-202x.2001.00050.x JF - Journal of Investigative Dermatology Symposium Proceedings AU - King, Lloyd E AU - Stratton, Charles W AU - Mitchell, William M AD - *Department of Medicine (Dermatology), Nashville Veterans Administration Medical Centers, Nashville, Tennessee, U.S.A. Y1 - 2001/12// PY - 2001 DA - Dec 2001 SP - 233 EP - 237 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 6 IS - 3 SN - 1087-0024, 1087-0024 KW - Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Skin KW - Dermatology KW - Pathogens KW - Arteriosclerosis KW - Inflammation KW - Opportunist infection KW - Wounds KW - Endothelial cells KW - Ulcers KW - Reviews KW - Chlamydophila pneumoniae KW - Pneumonia KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907161550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Investigative+Dermatology+Symposium+Proceedings&rft.atitle=Chlamydia+pneumoniae+and+Chronic+Skin+Wounds%3A+A+Focused+Review&rft.au=King%2C+Lloyd+E%3BStratton%2C+Charles+W%3BMitchell%2C+William+M&rft.aulast=King&rft.aufirst=Lloyd&rft.date=2001-12-01&rft.volume=6&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Journal+of+Investigative+Dermatology+Symposium+Proceedings&rft.issn=10870024&rft_id=info:doi/10.1046%2Fj.0022-202x.2001.00050.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Macrophages; Endothelial cells; Skin; Ulcers; Reviews; Dermatology; Arteriosclerosis; Pathogens; Pneumonia; Wounds; Opportunist infection; Inflammation; Chlamydophila pneumoniae DO - http://dx.doi.org/10.1046/j.0022-202x.2001.00050.x ER - TY - JOUR T1 - Determination of ototoxicity of common otic drops using isolated cochlear outer hair cells. AN - 85365589; pmid-11802005 AB - Otic drops are commonly used not only for otitis externa, but also for otorrhea in the presence of tympanostomy tubes or tympanic membrane perforations. Many studies have demonstrated the ototoxicity of common otic preparations such as Cortisporin otic drops (Monarch Pharmaceuticals, Bristol, TN). The purpose of this study was to assess the relative ototoxicity of common otic preparations by direct exposure to isolated cochlear outer hair cells (OHCs).OHCs from adult chinchilla cochlea were exposed to standard bathing solution (control), acetic acid, Acetasol HC (Alpharma USPD Inc., Baltimore, MD), Gentacidin (CIBA Vision Ophthalmics, Atlanta, GA), and Tobradex (Alcon, Fort Worth, TX). The cells were observed using an inverted microscope, and the images were recorded in digital still-frame and video, and analyzed on the Image Pro-Plus 3.0 program (Media Cybernetics, Silver Spring, MD).As measured by time to cell death and change in morphology of OHCs, acetic acid with or without hydrocortisone was most toxic to OHCs. Cortisporin was more cytotoxic than gentamicin and Tobradex. JF - The Laryngoscope AU - Jinn, T H AU - Kim, P D AU - Russell, P T AU - Church, C A AU - John, E O AU - Jung, T T AD - Division of Otolaryngology--Head and Neck Surgery, Department of Surgery, Loma Linda University School of Medicine and Jerry L Pettis Memorial Veterans Administration Hospital, Loma Linda, California, USA. Y1 - 2001/12// PY - 2001 DA - Dec 2001 SP - 2105 EP - 2108 VL - 111 IS - 12 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - *Acetic Acid: toxicity KW - Administration, Topical KW - Animals KW - Cell Size: drug effects KW - Cell Survival: drug effects KW - Cells, Cultured KW - Chinchilla KW - Drug Combinations KW - *Gentamicins: toxicity KW - *Hair Cells, Auditory, Outer: drug effects KW - Hair Cells, Auditory, Outer: ultrasonography KW - *Hydrocortisone: toxicity KW - *Neomycin: toxicity KW - *Polymyxin B: toxicity KW - *Tobramycin: toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85365589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Determination+of+ototoxicity+of+common+otic+drops+using+isolated+cochlear+outer+hair+cells.&rft.au=Jinn%2C+T+H%3BKim%2C+P+D%3BRussell%2C+P+T%3BChurch%2C+C+A%3BJohn%2C+E+O%3BJung%2C+T+T&rft.aulast=Jinn&rft.aufirst=T&rft.date=2001-12-01&rft.volume=111&rft.issue=12&rft.spage=2105&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Differential effects of bacterial toxins on mitogenic actions of sodium fluoride and those of aluminum fluoride in human TE85 osteosarcoma cells AN - 815538267; 13863391 AB - This study compared the effects of cholera toxin (CTX) and pertussis toxin (PTX) on the actions of sodium fluoride (NaF) and those of aluminum fluoride (AlF sub(3)) on cell proliferation and differentiation, as well as tyrosine phosphorylation level of MAP kinase (MAPK) in human bone cells. NaF and AlF sub(3) each significantly stimulated the proliferation of human TE85 osteosarcoma cells, increased cellular alkaline phosphatase (ALP) activity, and increased MAPK tyrosine phosphorylation level. CTX completely blocked the bone cell anabolic activities of both NaF and AlF sub(3). While PTX (2 ng/ml) inhibited the bone cell actions of NaF, it had no significant effect on those of AlF sub(3). Both CTX and PTX completely blocked the stimulatory action of AlF sub(3) on MAPK tyrosine phosphorylation, but neither toxin had an effect on the action of NaF on MAPK tyrosine phosphorylation. In conclusion, PTX and CTX had contrasting effects on the anabolic bone cell actions of NaF and AlF sub(3) actions. These findings argue against the hypothesis that the osteogenic activity of NaF is mediated via the formation of AlF sub(3) in human TE85 osteosarcoma cells. JF - Molecular and Cellular Biochemistry AU - Hashimoto, Hideki AU - Lau, K-HWilliam AD - Department of Medicine, Loma Linda University, USA, laub@lom.med.va.gov Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 91 EP - 98 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 228 IS - 1-2 SN - 0300-8177, 0300-8177 KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts; Calcium & Calcified Tissue Abstracts KW - Bacteria KW - MAP kinase KW - Tyrosine KW - pertussis toxin KW - Collagen KW - Protein-tyrosine-phosphatase KW - Bone KW - Differentiation KW - Sodium fluoride KW - Alkaline phosphatase KW - Osteosarcoma cells KW - Phosphorylation KW - Cholera toxin KW - Fluoride KW - Aluminum KW - Cell proliferation KW - X 24370:Natural Toxins KW - J 02330:Biochemistry KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815538267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biochemistry&rft.atitle=Differential+effects+of+bacterial+toxins+on+mitogenic+actions+of+sodium+fluoride+and+those+of+aluminum+fluoride+in+human+TE85+osteosarcoma+cells&rft.au=Hashimoto%2C+Hideki%3BLau%2C+K-HWilliam&rft.aulast=Hashimoto&rft.aufirst=Hideki&rft.date=2001-12-01&rft.volume=228&rft.issue=1-2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biochemistry&rft.issn=03008177&rft_id=info:doi/10.1023%2FA%3A1013320625846 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - MAP kinase; Tyrosine; Protein-tyrosine-phosphatase; Collagen; pertussis toxin; Bone; Sodium fluoride; Differentiation; Alkaline phosphatase; Phosphorylation; Osteosarcoma cells; Fluoride; Cholera toxin; Aluminum; Cell proliferation; Bacteria DO - http://dx.doi.org/10.1023/A:1013320625846 ER - TY - JOUR T1 - Variability in the assessment of adverse events in a multicenter clinical trial. AN - 72417566; 11813935 AB - Consistent documentation, characterization, and evaluation of adverse events (AEs) are needed during multicenter clinical trials to ensure accuracy of data reported to the US Food and Drug Administration and in the medical literature. The purpose of this study was to identify and characterize variations in the assessment of AEs by clinical trial personnel. During the annual meeting of personnel from a multicenter, controlled clinical trial of an investigational new drug treatment for opioid dependence, an oral presentation of procedures for AE data collection was given to 25 principal investigators and ancillary study personnel who assessed AEs for the study. A post-test using 3 hypothetical AE cases in which AEs were categorized by type of reaction, relatedness to study drug, severity, action taken, and outcome was completed by study participants. Cases and expected responses were reviewed for content and validity by clinical research pharmacists who were not involved with the study. The level of agreement with expected responses was assessed using McNemar symmetry chi-square tests. Assessments of type of AE, relatedness to study drug, and severity were less frequently aligned with expected responses than were action taken and outcome (P < 0.013). Less consistency with expected responses was found in I case than in the other 2, suggesting that certain types of AEs may be more difficult to assess. There was considerable variability in categorization of AEs in an exercise following training for AE data collection. Type of report, relatedness, and severity were found to have more variability in reporting than did action taken or outcome. The results suggest that unless data are gathered to verify reliability of reporting, subcategorization of AE data should be undertaken cautiously. Further research is needed regarding methods for improving consistency in reporting of AEs. JF - Clinical therapeutics AU - Raisch, D W AU - Troutman, W G AU - Sather, M R AU - Fudala, P J AD - Department of Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, College of Pharmacy, University of New Mexico, Albuquerque 87106, USA. dennis.raisch@csp.research.med.va.gov Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 2011 EP - 2020 VL - 23 IS - 12 SN - 0149-2918, 0149-2918 KW - Index Medicus KW - Documentation KW - Reproducibility of Results KW - Humans KW - Research Personnel KW - Multicenter Studies as Topic KW - Drug-Related Side Effects and Adverse Reactions KW - Clinical Trials as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72417566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+therapeutics&rft.atitle=Variability+in+the+assessment+of+adverse+events+in+a+multicenter+clinical+trial.&rft.au=Raisch%2C+D+W%3BTroutman%2C+W+G%3BSather%2C+M+R%3BFudala%2C+P+J&rft.aulast=Raisch&rft.aufirst=D&rft.date=2001-12-01&rft.volume=23&rft.issue=12&rft.spage=2011&rft.isbn=&rft.btitle=&rft.title=Clinical+therapeutics&rft.issn=01492918&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-12 N1 - Date created - 2002-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cyclooxygenase-2 selective inhibitors and the kidney. AN - 72409163; 11805541 AB - Cyclooxygenases (COX) are the target of non-steroidal anti-inflammatory drugs (NSAIDs) which exert their therapeutic effect by blocking COX's capacity to metabolize arachidonate to a series of biologically active fatty acids, designated prostaglandins. NSAID use is associated with two major tonicities: gastrointestinal bleeding and renal dysfunction. In the setting of significant physiologic stress, renal function becomes dependent upon prostaglandins and NSAID use may be associated with acute deterioration of renal function, including development of sodium retention, edema, hypertension, hyperkalemia, and or papillary necrosis. Two isoforms, COX1 and COX2, have been identified. They are products of distinct genes and their expression is under different regulatory control. Both COX1 and COX2 are highly expressed in the kidney and both are inhibited by conventional NSAIDs. Accumulating data using recently developed selective COX2 inhibitors suggest that while these agents spare the gastrointestinal tract they have similar renal effects as non-selective NSAIDs. Therefore, caution should be taken when prescribing selective COX2 inhibitor to patients, especially to patients with predisposed physiologic stress. JF - Current opinion in critical care AU - Breyer, M D AU - Hao, C AU - Qi, Z AD - Division of Nephrology and Department of Medicine, Veterans Administration Medical Center and Vanderbilt University, Nashville, Tennessee 37232, USA. matthew.breyer@mcmail.vanderbilt.edu Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 393 EP - 400 VL - 7 IS - 6 SN - 1070-5295, 1070-5295 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase 2 Inhibitors KW - Cyclooxygenase Inhibitors KW - Isoenzymes KW - Membrane Proteins KW - Prostaglandins KW - Cyclooxygenase 1 KW - EC 1.14.99.1 KW - Cyclooxygenase 2 KW - PTGS1 protein, human KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Ptgs1 protein, mouse KW - Ptgs1 protein, rat KW - Index Medicus KW - Animals KW - Humans KW - Juxtaglomerular Apparatus -- metabolism KW - Prostaglandins -- biosynthesis KW - Rabbits KW - Mice KW - Rats KW - Hyperkalemia -- etiology KW - Hypertension -- etiology KW - Prostaglandin-Endoperoxide Synthases -- biosynthesis KW - Isoenzymes -- antagonists & inhibitors KW - Cyclooxygenase Inhibitors -- adverse effects KW - Kidney -- metabolism KW - Isoenzymes -- biosynthesis KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Kidney -- drug effects KW - Kidney Diseases -- chemically induced KW - Cyclooxygenase Inhibitors -- pharmacology KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72409163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+critical+care&rft.atitle=Cyclooxygenase-2+selective+inhibitors+and+the+kidney.&rft.au=Breyer%2C+M+D%3BHao%2C+C%3BQi%2C+Z&rft.aulast=Breyer&rft.aufirst=M&rft.date=2001-12-01&rft.volume=7&rft.issue=6&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+critical+care&rft.issn=10705295&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-22 N1 - Date created - 2002-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anaphylactoid reaction to etomidate: report of a case. AN - 72377275; 11755328 AB - We report an anaphylactoid reaction to etomidate twice in a 60-year-old male with coronary artery disease and peripheral vascular disease. Following the first anaphylactoid reaction, the patient developed myocardial infarction. In addition, the patient's blood was moderately positive for latex antibodies, which made the differential diagnosis difficult. We concluded that the patient had anaphylactoid reaction to etomidate due to the temporal relationship to induction with the drug. The patient did not manifest similar reaction to other induction drugs used for other surgeries. The patient recovered from both incidents of anaphylactoid reaction to etomidate following intravenous administration of epinephrine and fluids. JF - Journal of clinical anesthesia AU - Moorthy, S S AU - Laurent, B AU - Pandya, P AU - Fry, V AD - Richard L. Roudebush Veterans Administration Medical Center, and Department of Anesthesia, Indiana University Medical Center, Indianapolis, IN 46202, USA. sreenivasa.moorthy@med.va.gov Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 582 EP - 584 VL - 13 IS - 8 SN - 0952-8180, 0952-8180 KW - Anesthetics, Intravenous KW - 0 KW - Etomidate KW - Z22628B598 KW - Index Medicus KW - Latex Hypersensitivity -- diagnosis KW - Myocardial Infarction -- etiology KW - Diagnosis, Differential KW - Latex Hypersensitivity -- complications KW - Humans KW - Middle Aged KW - Intraoperative Complications KW - Male KW - Anaphylaxis -- drug therapy KW - Anaphylaxis -- chemically induced KW - Drug Hypersensitivity -- etiology KW - Anaphylaxis -- diagnosis KW - Anesthetics, Intravenous -- adverse effects KW - Etomidate -- adverse effects KW - Drug Hypersensitivity -- complications KW - Drug Hypersensitivity -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72377275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+anesthesia&rft.atitle=Anaphylactoid+reaction+to+etomidate%3A+report+of+a+case.&rft.au=Moorthy%2C+S+S%3BLaurent%2C+B%3BPandya%2C+P%3BFry%2C+V&rft.aulast=Moorthy&rft.aufirst=S&rft.date=2001-12-01&rft.volume=13&rft.issue=8&rft.spage=582&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+anesthesia&rft.issn=09528180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-31 N1 - Date created - 2001-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Justification for a new cohort study of people aging with and without HIV infection. AN - 72370271; 11750202 AB - This supplement contains a series of papers supporting the justification, design, and implementation of a longitudinal cohort study of an aging HIV-positive and HIV-negative veteran population called the Veterans Aging Cohort Study (VACS). Although the papers cover a wide range of topics and several papers address methodologic issues not unique to a study of aging veterans, all are motivated by a unifying set of assumptions. Specifically: (a) HIV/AIDS is a chronic disease in an aging population; (b) conditions among HIV-positive and -negative patients in care have overlapping etiologies; (c) individuals with pre-existing organ injury are at increased risk for iatrogenic injury; (d) cohort studies are uniquely suited to the study of chronic disease complicated by aging, comorbid conditions, drug toxicities, and substance use/abuse; (e) VACS is well positioned to study HIV as a chronic disease in an aging population. JF - Journal of clinical epidemiology AU - Justice, A C AU - Landefeld, C S AU - Asch, S M AU - Gifford, A L AU - Whalen, C C AU - Covinsky, K E AD - Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, University Drive C 11E-124 (130-U), Pittsburgh, PA 15240, USA. Amy.Justice@med.va.gov Y1 - 2001/12// PY - 2001 DA - December 2001 SP - S3 EP - S8 VL - 54 Suppl 1 SN - 0895-4356, 0895-4356 KW - Index Medicus KW - Humans KW - Chronic Disease KW - Longitudinal Studies KW - HIV Seronegativity KW - United States -- epidemiology KW - Research Design KW - HIV Seropositivity -- epidemiology KW - Comorbidity KW - Veterans KW - Aging -- physiology KW - HIV Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72370271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+epidemiology&rft.atitle=Justification+for+a+new+cohort+study+of+people+aging+with+and+without+HIV+infection.&rft.au=Justice%2C+A+C%3BLandefeld%2C+C+S%3BAsch%2C+S+M%3BGifford%2C+A+L%3BWhalen%2C+C+C%3BCovinsky%2C+K+E&rft.aulast=Justice&rft.aufirst=A&rft.date=2001-12-01&rft.volume=54+Suppl+1&rft.issue=&rft.spage=S3&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+epidemiology&rft.issn=08954356&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-29 N1 - Date created - 2001-12-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Symptom factor analysis, clinical findings, and functional status in a population-based case control study of Gulf War unexplained illness. AN - 72365819; 11765674 AB - Few epidemiological studies have been conducted that have incorporated clinical evaluations of Gulf War veterans with unexplained health symptoms and healthy controls. We conducted a mail survey of 2022 Gulf War veterans residing in the northwest United States and clinical examinations on a subset of 443 responders who seemed to have unexplained health symptoms or were healthy. Few clinical differences were found between cases and controls. The most frequent unexplained symptoms were cognitive/psychological, but significant overlap existed with musculoskeletal and fatigue symptoms. Over half of the veterans with unexplained musculoskeletal pain met the criteria for fibromyalgia, and a significant portion of the veterans with unexplained fatigue met the criteria for chronic fatigue syndrome. Similarities were found in the clinical interpretation of unexplained illness in this population and statistical factor analysis performed by this study group and others. JF - Journal of occupational and environmental medicine AU - Bourdette, D N AU - McCauley, L A AU - Barkhuizen, A AU - Johnston, W AU - Wynn, M AU - Joos, S K AU - Storzbach, D AU - Shuell, T AU - Sticker, D AD - Portland Veterans Affairs Medical Center, Department of Neurology, Mailcode P-3-NEURO, 3710 SW US Veteran's Hospital Road, Portland, OR 97201, USA. Dennis.Bourdette@med.va.gov Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 1026 EP - 1040 VL - 43 IS - 12 SN - 1076-2752, 1076-2752 KW - Index Medicus KW - Warfare KW - Fibromyalgia -- etiology KW - Humans KW - Health Surveys KW - Fatigue Syndrome, Chronic -- etiology KW - Adult KW - Surveys and Questionnaires KW - Case-Control Studies KW - United States -- epidemiology KW - Middle East KW - Male KW - Occupational Exposure -- statistics & numerical data KW - Persian Gulf Syndrome -- complications KW - Veterans -- statistics & numerical data KW - Persian Gulf Syndrome -- epidemiology KW - Occupational Exposure -- adverse effects KW - Persian Gulf Syndrome -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72365819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Symptom+factor+analysis%2C+clinical+findings%2C+and+functional+status+in+a+population-based+case+control+study+of+Gulf+War+unexplained+illness.&rft.au=Bourdette%2C+D+N%3BMcCauley%2C+L+A%3BBarkhuizen%2C+A%3BJohnston%2C+W%3BWynn%2C+M%3BJoos%2C+S+K%3BStorzbach%2C+D%3BShuell%2C+T%3BSticker%2C+D&rft.aulast=Bourdette&rft.aufirst=D&rft.date=2001-12-01&rft.volume=43&rft.issue=12&rft.spage=1026&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-11 N1 - Date created - 2001-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prostaglandin inhibitors and the chemoprevention of noncolonic malignancy. AN - 72357594; 11764539 AB - Much has been learned about the role of NSAIDs as cancer preventives through epidemiologic and experimental studies. The pathways of carcinogenesis in the gastrointestinal tract are initiated by many different genetic, environmental, infective, and lifestyle factors. It is possible that the final common pathway of all these malignancies may have some common features. It is conceivable that head and neck, esophageal, gastric, and colorectal epithelial carcinogenesis all are influenced by or require COX-2 up-regulation as a step toward transformation. Intuitively, it is possible that selective COX-2 inhibitors may have a preventive role in all these epithelial malignancies. Today's challenge is to translate this information into clinical trials to define what role, if any, COX inhibition might play in the prevention of these malignancies. JF - Gastroenterology clinics of North America AU - Krishnan, K AU - Brenner, D E AD - Division of Hematology and Oncology, Department of Internal Medicine, James H. Quillen Veterans Administration Medical Center, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA. krishnak@etsu.edu Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 981 EP - 1000 VL - 30 IS - 4 SN - 0889-8553, 0889-8553 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase 2 Inhibitors KW - Cyclooxygenase Inhibitors KW - Isoenzymes KW - Membrane Proteins KW - Prostaglandin Antagonists KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Index Medicus KW - Isoenzymes -- antagonists & inhibitors KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Humans KW - Disease Progression KW - Prostaglandin Antagonists -- therapeutic use KW - Esophageal Neoplasms -- prevention & control KW - Cyclooxygenase Inhibitors -- therapeutic use KW - Adenocarcinoma -- physiopathology KW - Carcinoma, Squamous Cell -- physiopathology KW - Esophageal Neoplasms -- physiopathology KW - Carcinoma, Squamous Cell -- prevention & control KW - Barrett Esophagus -- physiopathology KW - Stomach Neoplasms -- physiopathology KW - Stomach Neoplasms -- prevention & control KW - Adenocarcinoma -- prevention & control KW - Barrett Esophagus -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72357594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology+clinics+of+North+America&rft.atitle=Prostaglandin+inhibitors+and+the+chemoprevention+of+noncolonic+malignancy.&rft.au=Krishnan%2C+K%3BBrenner%2C+D+E&rft.aulast=Krishnan&rft.aufirst=K&rft.date=2001-12-01&rft.volume=30&rft.issue=4&rft.spage=981&rft.isbn=&rft.btitle=&rft.title=Gastroenterology+clinics+of+North+America&rft.issn=08898553&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-13 N1 - Date created - 2001-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuromuscular blockers in surgery and intensive care, Part 1. AN - 72355896; 11763807 AB - The historical development, pharmacology, pharmacodynamics, pharmacokinetics, clinical applications, pharmacologic basis for selection, adverse effects, and cost of neuromuscular blockers (NMBs) are discussed. The first NMB to be used was tubocurarine. During neurotransmission, acetylcholine is synthesized, stored in vesicles at the neuromuscular junction, released into the synapse, and bound to nicotinic receptors in the muscle end plate. For muscle contraction to occur, the impulse generated in a neuron's cell body must create an action potential that is chemically transmitted across the synapse. The postsynaptic nicotinic receptor at the neuromuscular junction is the major site of action of depolarizing and nondepolarizing NMBs. All NMBs have the potential for cross-reactivity at other nicotinic and muscarinic sites. Drug interactions most commonly occur between NMBs and inhalation anesthetics, certain antimicrobials, calcium-channel blockers, and anticholinesterases. When selecting an NMB, an agent's onset and duration of action must be considered. NMBs can be used on a short-term or long-term basis. Apart from cost, the choice of an NMB is made on the basis of its adverse-reaction profile, pharmacokinetics, and indications for use. Monitoring tools, their use, the rationale for their use, and the interpretation of the results they provide are unique. The patterns of peripheral nerve stimulation vary and elicit different characteristics of nondepolarizing neuromuscular blockade. The effectiveness of reversal agents is proportional to the degree of blockade. The mechanism of action of anticholinesterases involves inhibition of acetylcholinesterase. The expensive NMBs should be conserved for use in surgery, while the cheaper, long-acting [corrected] agents should be used in the intensive care unit. An understanding of the pharmacology, pharmacodynamics, and pharmacokinetics of NMBs will help health care providers gain expertise in the selection and use of these agents. JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - McManus, M C AD - School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, MA, USA. mcmanus.claire@boston.va.gov Y1 - 2001/12/01/ PY - 2001 DA - 2001 Dec 01 SP - 2287 EP - 2299 VL - 58 IS - 23 SN - 1079-2082, 1079-2082 KW - Neuromuscular Blocking Agents KW - 0 KW - Index Medicus KW - Humans KW - Neuromuscular Blocking Agents -- adverse effects KW - Anesthesia KW - Neuromuscular Blocking Agents -- therapeutic use KW - Neuromuscular Blocking Agents -- pharmacokinetics KW - Neuromuscular Blocking Agents -- pharmacology KW - Critical Care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72355896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Neuromuscular+blockers+in+surgery+and+intensive+care%2C+Part+1.&rft.au=McManus%2C+M+C&rft.aulast=McManus&rft.aufirst=M&rft.date=2001-12-01&rft.volume=58&rft.issue=23&rft.spage=2287&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-05-07 N1 - Date created - 2001-12-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Am J Health Syst Pharm 2002 Jan 1;59(1):16 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Social support and abstinence from opiates and cocaine during opioid maintenance treatment. AN - 72285630; 11714591 AB - Social support may play an important role in helping drug users achieve abstinence; however these benefits may depend on the type of support experienced. In this prospective observational study, we examined the extent to which general and abstinence-specific support, both structural and functional, predicted opiate and cocaine abstinence in 128 opioid maintenance patients receiving either methadone or LAAM. A new multidimensional self-report instrument assessing abstinence-specific functional support was developed for the study. Previously validated measures were used to assess the remaining types of support. With baseline abstinence and other statistically important covariates adjusted, hierarchical logistic regression analyses demonstrated that the associations between social support at study baseline and biochemically confirmed abstinence 3 months later varied by type of support and by drug. Greater abstinence-specific structural support (operationalized as fewer drug users in the social network) and decreases in three types of negative abstinence-specific functional support (Complaints about Drug Use, Drug Exposure, and Demoralization) predicted cocaine, but not opiate abstinence. There were no effects for general support, whether structural or functional, on abstinence from either drug. Interventions that focus on modifying patients' abstinence-specific support may be helpful in reducing the high rates of cocaine use disorders in this population. JF - Drug and alcohol dependence AU - Wasserman, D A AU - Stewart, A L AU - Delucchi, K L AD - Department of Psychiatry, University of California, San Francisco, CA 94103, USA. david.wasserman@med.va.gov Y1 - 2001/12/01/ PY - 2001 DA - 2001 Dec 01 SP - 65 EP - 75 VL - 65 IS - 1 SN - 0376-8716, 0376-8716 KW - Analgesics, Opioid KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Methadone -- therapeutic use KW - Chi-Square Distribution KW - Humans KW - Aged KW - Substance Abuse Treatment Centers -- statistics & numerical data KW - Prospective Studies KW - Behavior Therapy KW - Logistic Models KW - Adult KW - Treatment Outcome KW - Analgesics, Opioid -- therapeutic use KW - Follow-Up Studies KW - Middle Aged KW - Statistics, Nonparametric KW - Female KW - Male KW - Opioid-Related Disorders -- psychology KW - Cocaine-Related Disorders -- psychology KW - Opioid-Related Disorders -- therapy KW - Cocaine-Related Disorders -- therapy KW - Social Support UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72285630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Social+support+and+abstinence+from+opiates+and+cocaine+during+opioid+maintenance+treatment.&rft.au=Wasserman%2C+D+A%3BStewart%2C+A+L%3BDelucchi%2C+K+L&rft.aulast=Wasserman&rft.aufirst=D&rft.date=2001-12-01&rft.volume=65&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-04 N1 - Date created - 2001-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A clinical review of non-age-related cataracts. AN - 71328346; 12363250 AB - A cataract is any opacity or partial loss of transparency of the lens, whether the absence of transparency is small or complete. Pupil dilation affords a view of a legion of internal variations and abnormalities of the human crystalline lens which often tell us about its events and insults, as well as when in the patient's life these might have occurred. In this article, we review the major non-age-related association of cataractogenesis with respect to metabolic, environmental, ocular-specific, infectious, dermatologic, retinal, and toxic etiologies. The data are presented from the clinical perspective of incidence for a given condition and cataract type. Two simplified summary reference sheets are provided: (1) frequency of occurrence vs. etiology and (2) cataract type vs. etiology (color-coded). The busy clinician can refer to both tools chair-side. The human body has numerous methods of signaling insults and abnormalities. As the crystalline lens is an important gauge of overall health, an argument can be made for routine dilation of all patients. This information is also essential for future neutraceutical and pharmaceutical therapeutic intervention. JF - Optometry (St. Louis, Mo.) AU - Richer, S P AU - Yonatan, E AU - Harper, C K AU - McNelis, M AU - Rudy, D R AU - Perdue, A AD - DVA Medical Center, North Chicago, Illinois 60064-3095, USA. stuart.richer@med.va.gov Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 767 EP - 778 VL - 72 IS - 12 SN - 1529-1839, 1529-1839 KW - Index Medicus KW - Environment KW - Eye Diseases -- complications KW - Humans KW - Dermatitis, Atopic -- complications KW - Metabolic Diseases -- complications KW - Incidence KW - Retinal Diseases -- complications KW - Infection -- complications KW - Cataract -- epidemiology KW - Cataract -- chemically induced KW - Cataract -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71328346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Optometry+%28St.+Louis%2C+Mo.%29&rft.atitle=A+clinical+review+of+non-age-related+cataracts.&rft.au=Richer%2C+S+P%3BYonatan%2C+E%3BHarper%2C+C+K%3BMcNelis%2C+M%3BRudy%2C+D+R%3BPerdue%2C+A&rft.aulast=Richer&rft.aufirst=S&rft.date=2001-12-01&rft.volume=72&rft.issue=12&rft.spage=767&rft.isbn=&rft.btitle=&rft.title=Optometry+%28St.+Louis%2C+Mo.%29&rft.issn=15291839&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-23 N1 - Date created - 2002-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prolonged Colonization with Vancomycin-Resistant Enterococcus faecium in Long-Term Care Patients and the Significance of "Clearance" AN - 18448344; 5427392 AB - Little is known about the persistence of colonization with vancomycin-resistant Enterococcus faecium (VRE) in the nononcologic, non-intensive care unit patient. We studied all patients who had VRE isolated on greater than or equal to 2 occasions of >1 year apart (Study A) and those who had been "cleared" of VRE colonization after 3 negative stool cultures (Study B). Twelve patients had stored VRE isolates recovered >1 year apart (Study A), and 58% of paired isolates were genotypically related according to pulsed field gel electrophoresis patterns. In Study B, stool samples were obtained weekly from 21 "cleared" patients for 5 weeks, which revealed that 24% were VRE positive. For these culture-positive patients, 72% of the cultures failed to detect VRE. Recent antibiotic use was significantly more common in the culture-positive patients, as compared with culture-negative patients (P = .003). Colonization with VRE may persist for years, even if the results of intercurrent surveillance stool and index site cultures are negative. Cultures for detection of VRE in stool samples obtained from patients declared "cleared" are insensitive. JF - Clinical Infectious Diseases AU - Baden, L R AU - Thiemke, W AU - Skolnik, A AU - Chambers, R AU - Strymish, J AU - Gold, H S AU - Moellering, RC Jr AU - Eliopoulos, G M AD - Division of Infectious Disease, Beth Israel Deaconess Medical Center, The Brockton/West Roxbury Veterans Administration Medical Center, Harvard Medical School, Boston, USA Y1 - 2001/11/15/ PY - 2001 DA - 2001 Nov 15 SP - 1654 EP - 1660 VL - 33 IS - 10 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18448344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Prolonged+Colonization+with+Vancomycin-Resistant+Enterococcus+faecium+in+Long-Term+Care+Patients+and+the+Significance+of+%22Clearance%22&rft.au=Baden%2C+L+R%3BThiemke%2C+W%3BSkolnik%2C+A%3BChambers%2C+R%3BStrymish%2C+J%3BGold%2C+H+S%3BMoellering%2C+RC+Jr%3BEliopoulos%2C+G+M&rft.aulast=Baden&rft.aufirst=L&rft.date=2001-11-15&rft.volume=33&rft.issue=10&rft.spage=1654&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Microinjection of bombesin into the ventrolateral reticular formation inhibits peripherally stimulated gastric acid secretion through spinal pathways in rats. AN - 72237011; 11684036 AB - Bombesin injected into the cisterna magna potently inhibits gastric acid secretion stimulated by intravenous infusion of pentagastrin. Sites in the medulla oblongata where bombesin acts to suppress gastric acid secretion were investigated in urethane-anesthetized rats with gastric cannula. Bombesin or vehicle was injected into the medullary parenchyma or intracisternally (i.c.) 60 min after the start of an intravenous pentagastrin infusion; gastric acid secretion was monitored every 10 min for 20 min before and 150 min after the start of pentagastrin. Bombesin (0.2, 0.6 or 6.2 pmol) microinjected into the ventrolateral reticular formation (VLRF) inhibited dose-dependently the net acid response to pentagastrin by 40.8+/-11.1, 75.4+/-12.8 and 96.7+/-19.4%, respectively, at the 40-50 min period after microinjection compared with the vehicle group. Bombesin action in the VLRF was long lasting (96% inhibition still observed at 90 min after 6.2 pmol), and completely abolished by cervical spinal cord transection at the C6 level. By contrast, bombesin injected i.c. at 0.2 or 0.6 pmol had no effect while at 6.2 pmol, there was a 79.0+/-3.9% peak inhibition of pentagastrin-stimulated acid secretion. Bombesin (6.2 pmol) injected into the dorsal motor nucleus reduced the acid response to pentagastrin by 29%. The parvicellular and gigantocellular reticular nuclei were not responsive to bombesin. These results indicate that bombesin acts in the VLRF to inhibit pentagastrin-stimulated gastric acid secretion through spinal pathways, suggesting a potential role of medullary VLRF area in the sympathetic control of gastric acid secretion. JF - Brain research AU - Ishikawa, T AU - Yang, H AU - Taché, Y AD - CURE: Digestive Diseases Research Center, Veterans Administration Greater Los Angeles Healthcare System, Department of Medicine, Digestive Diseases Division and Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 90073, USA. Y1 - 2001/11/09/ PY - 2001 DA - 2001 Nov 09 SP - 1 EP - 9 VL - 918 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Pentagastrin KW - EF0NX91490 KW - Bombesin KW - PX9AZU7QPK KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Pentagastrin -- pharmacology KW - Neural Inhibition -- drug effects KW - Gastric Mucosa -- innervation KW - Neural Inhibition -- physiology KW - Gastric Mucosa -- secretion KW - Male KW - Drug Interactions -- physiology KW - Injections, Intraventricular KW - Efferent Pathways -- metabolism KW - Spinal Cord -- metabolism KW - Sympathetic Nervous System -- drug effects KW - Medulla Oblongata -- cytology KW - Efferent Pathways -- cytology KW - Medulla Oblongata -- drug effects KW - Gastric Acid -- secretion KW - Reticular Formation -- drug effects KW - Sympathetic Nervous System -- cytology KW - Reticular Formation -- cytology KW - Spinal Cord -- drug effects KW - Sympathetic Nervous System -- metabolism KW - Bombesin -- pharmacology KW - Reticular Formation -- metabolism KW - Efferent Pathways -- drug effects KW - Medulla Oblongata -- metabolism KW - Spinal Cord -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72237011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Microinjection+of+bombesin+into+the+ventrolateral+reticular+formation+inhibits+peripherally+stimulated+gastric+acid+secretion+through+spinal+pathways+in+rats.&rft.au=Ishikawa%2C+T%3BYang%2C+H%3BTach%C3%A9%2C+Y&rft.aulast=Ishikawa&rft.aufirst=T&rft.date=2001-11-09&rft.volume=918&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-04 N1 - Date created - 2001-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of pepsin in acid injury to esophageal epithelium. AN - 85363562; pmid-11721751 AB - The development of reflux esophagitis in humans is a process resulting from esophageal exposure to refluxed gastric contents. There is no doubt that damage to the esophageal epithelium requires exposure to gastric acid; however, the role of refluxed pepsin as contributor to this damage seems to be underappreciated.The role of physiological concentrations of pepsin was examined in Ussing chambered rabbit esophageal epithelium and in cultured esophageal epithelial cells.The results of this investigation reaffirmed the ability of pepsin to increase the rate and degree of esophageal cell and tissue damage at acidic pH, although the range of activity was limited to pH < 3.0. Moreover, the increased rate of tissue damage by acidified pepsin rapidly (within 15 min) produced a lesion that was irreversible, whereas, in a similar time frame, acid alone produced a lesion that was completely reversible. This early lesion by acidified pepsin was localized by performance of mannitol fluxes in apparently undamaged esophageal epithelium on light microscopy to the intercellular junctional complex. Further acid produced similar degrees of cell killing as acidified pepsin at pH < 3.0 in rabbit esophageal epithelial cells in suspension but not when growing on coverslips or present within intact epithelium.These studies suggest that acidified pepsin plays a key role in the development of reflux esophagitis by producing an early irreversible lesion that results in an increase in paracellular permeability, which indirect evidence suggests is due to damage to the junctional complex. The irreversibility of the increase in paracellular permeability is likely to aid conversion of nonerosive to erosive damage to the epithelium by permitting luminal acid greater access to the basolateral membrane of esophageal epithelial cells, which is known to be acid permeable. JF - The American journal of gastroenterology AU - Tobey, N A AU - Hosseini, S S AU - Caymaz-Bor, C AU - Wyatt, H R AU - Orlando, G S AU - Orlando, R C AD - Department of Medicine, Tulane University School of Medicine and the Veterans Administration Medical Center, New Orleans, Louisiana 70112, USA. Y1 - 2001/11// PY - 2001 DA - Nov 2001 SP - 3062 EP - 3070 VL - 96 IS - 11 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Epithelial Cells: pathology KW - Epithelium: pathology KW - *Esophagus: pathology KW - Gastric Acid KW - *Pepsin A: physiology KW - Rabbits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85363562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=The+role+of+pepsin+in+acid+injury+to+esophageal+epithelium.&rft.au=Tobey%2C+N+A%3BHosseini%2C+S+S%3BCaymaz-Bor%2C+C%3BWyatt%2C+H+R%3BOrlando%2C+G+S%3BOrlando%2C+R+C&rft.aulast=Tobey&rft.aufirst=N&rft.date=2001-11-01&rft.volume=96&rft.issue=11&rft.spage=3062&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Ofloxacin: a probable cause of toxic epidermal necrolysis. AN - 72301225; 11724089 AB - To report a fatal case of toxic epidermal necrolysis in a man who was treated with oral ofloxacin for epididymitis. A 75-year-old white man received 23.6 grams of ofloxacin over a 51-day period for epididymitis. He experienced a severe skin reaction diagnosed as toxic epidermal necrolysis. The man died from complications related to toxic epidermal necrolysis. Toxic epidermal necrolysis is an infrequent, yet often fatal, severe, systemic, cutaneous disease most often the result of an adverse drug reaction. Fluoroquinolones have rarely been implicated in cases of toxic epidermal necrolysis. A MEDLINE search from 1966 to December 2000 revealed no reports of toxic epidermal necrolysis, erythema multiforme, or Stevens-Johnson syndrome due to ofloxacin therapy. However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given. This report rules out other causes of toxic epidermal necrolysis and implicates ofloxacin in what appears to be an atypical presentation of drug-induced toxic epidermal necrolysis. There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis. There are a few case reports of other fluoroquinolones that have been associated with toxic epidermal necrolysis. It is hoped that this case report creates awareness that ofloxacin-induced toxic epidermal necrolysis is possible. JF - The Annals of pharmacotherapy AU - Melde, S L AD - Central Texas Veterans Health Care System, Pharmacy Service, Temple 76504-7493, USA. Stephen.Melde@Med.VA.Gov Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 1388 EP - 1390 VL - 35 IS - 11 SN - 1060-0280, 1060-0280 KW - Anti-Infective Agents KW - 0 KW - Ofloxacin KW - A4P49JAZ9H KW - Index Medicus KW - Fatal Outcome KW - Humans KW - Aged KW - Male KW - Epididymitis -- drug therapy KW - Anti-Infective Agents -- therapeutic use KW - Anti-Infective Agents -- adverse effects KW - Stevens-Johnson Syndrome -- pathology KW - Ofloxacin -- adverse effects KW - Ofloxacin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72301225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Ofloxacin%3A+a+probable+cause+of+toxic+epidermal+necrolysis.&rft.au=Melde%2C+S+L&rft.aulast=Melde&rft.aufirst=S&rft.date=2001-11-01&rft.volume=35&rft.issue=11&rft.spage=1388&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-04-08 N1 - Date created - 2001-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Creativity and chronic disease. Ludwig van Beethoven (1770-1827). AN - 72259342; 11694466 JF - The Western journal of medicine AU - Wolf, P AD - University of California, San Diego, VA Medical Center, USA. paul.wolf@med.va.gov Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 298 VL - 175 IS - 5 SN - 0093-0415, 0093-0415 KW - Abridged Index Medicus KW - Index Medicus KW - van Beethoven KW - Liver Cirrhosis, Alcoholic -- history KW - Humans KW - History, 19th Century KW - Deafness -- history KW - Deafness -- etiology KW - Chronic Disease KW - Germany KW - Male KW - Music -- history KW - Osteitis Deformans -- history KW - Famous Persons KW - Osteitis Deformans -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72259342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Western+journal+of+medicine&rft.atitle=Creativity+and+chronic+disease.+Ludwig+van+Beethoven+%281770-1827%29.&rft.au=Wolf%2C+P&rft.aulast=Wolf&rft.aufirst=P&rft.date=2001-11-01&rft.volume=175&rft.issue=5&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=The+Western+journal+of+medicine&rft.issn=00930415&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-07 N1 - Date created - 2001-11-05 N1 - Date revised - 2017-01-13 N1 - People - van Beethoven N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - van Beethoven ER - TY - JOUR T1 - Screening for mental illness in a Veterans Affairs women's health clinic. AN - 72243957; 11684750 AB - This study examined the prevalence of self-reported mental illness and related impairment in social and occupational functioning among 209 female veterans enrolled in a primary care clinic. Ninety-four (45 percent) of the women screened positive for at least one psychiatric disorder, 46 (22 percent) for two or more coexisting psychiatric disorders, and 40 (19 percent) for only subthreshold disorders. The degree of self-reported impairment in social and occupational functioning was strongly related to the number of psychiatric diagnoses. Women who were under the age of 50 and those who had a service-connected disability were more likely to screen positive for a mental disorder. JF - Psychiatric services (Washington, D.C.) AU - Bader, G AU - Ragsdale, K G AU - Franchina, J J AD - VA medical Center, Salem, Virginia 24153, USA. geoffrey.bader@med.va.gov Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 1521 EP - 1522 VL - 52 IS - 11 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - United States KW - Aged, 80 and over KW - United States Department of Veterans Affairs KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Female KW - Comorbidity KW - Prevalence KW - Mass Screening KW - Women's Health Services KW - Mental Disorders -- prevention & control KW - Mental Disorders -- epidemiology KW - Occupational Diseases -- prevention & control KW - Veterans -- psychology KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72243957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Screening+for+mental+illness+in+a+Veterans+Affairs+women%27s+health+clinic.&rft.au=Bader%2C+G%3BRagsdale%2C+K+G%3BFranchina%2C+J+J&rft.aulast=Bader&rft.aufirst=G&rft.date=2001-11-01&rft.volume=52&rft.issue=11&rft.spage=1521&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-14 N1 - Date created - 2001-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nuclear medicine survey recommendations for a changing regulatory environment. AN - 72218098; 11669196 AB - The revision of 10 CFR 35 approved on 23 September 2000 and due for implementation in 2001, reduces the number of required radiation and contamination surveys to one ambient radiation survey each day when an administration requiring a written directive is used. This paper compares the current requirements in 10 CFR 35; the single, remaining, specific requirement in the revised part 35; the Nuclear Regulatory Commission's guidance in the proposed NUREG SR1556 and the general requirement for surveys to demonstrate compliance with 10 CFR 20. We also make recommendations on what periodic surveys are prudent. JF - Health physics AU - Vernig, P G AU - Schumacher, T A AD - Denver VA Medical Center, CO, USA. peter.vernig@med.va.gov Y1 - 2001/11// PY - 2001 DA - November 2001 SP - S70 EP - S74 VL - 81 IS - 5 Suppl SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Data Collection -- standards KW - Humans KW - Radiation Protection -- standards KW - Nuclear Medicine -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72218098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Nuclear+medicine+survey+recommendations+for+a+changing+regulatory+environment.&rft.au=Vernig%2C+P+G%3BSchumacher%2C+T+A&rft.aulast=Vernig&rft.aufirst=P&rft.date=2001-11-01&rft.volume=81&rft.issue=5+Suppl&rft.spage=S70&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tracking occupational doses of transient workers. AN - 72215668; 11669194 AB - A number of radioactive material licensees in the United States are unaware that they are required to track the occupational doses their radiation workers receive outside thieir facilities. As a result, these licensees may be cited for not tracking offsite occupational doses and quite possible for allowing some individuals to exceed the annual limits established by regulatory agencies. The accounting of occupational doses to "transient" workers is a difficult task. Unfortunately, written guidance to assist licensees on how to properly address this issue is not available. This paper was developed to raise awareness among radiation safety professionals of the need to establish effective measures to properly track transient worker exposures and maintain compliance with regulatory limits. JF - Health physics AU - Michel, R AU - Zorn, M J AD - VA San Diego Healthcare System, CA 92161, USA. rene.michel@med.va.gov Y1 - 2001/11// PY - 2001 DA - November 2001 SP - S65 EP - S66 VL - 81 IS - 5 Suppl SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Radiation Dosage KW - Risk Factors KW - Humans KW - Radiation Monitoring KW - Occupational Exposure KW - Radiation Protection -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72215668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Tracking+occupational+doses+of+transient+workers.&rft.au=Michel%2C+R%3BZorn%2C+M+J&rft.aulast=Michel&rft.aufirst=R&rft.date=2001-11-01&rft.volume=81&rft.issue=5+Suppl&rft.spage=S65&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Understanding patient preferences for the treatment of lupus nephritis with adaptive conjoint analysis. AN - 72210236; 11606874 AB - Incorporation of patient preferences into treatment decisions is an essential component of medical care. Conjoint analysis is an established method of eliciting consumer preferences in market research and is being increasingly used to study patient preferences for health care. To examine the value of Adaptive Conjoint Analysis (ACA), a unique method of performing conjoint analysis, and to evaluate patient treatment preferences. Interactive computer survey. Consecutive women (n = 103) with lupus followed in three community rheumatology practices. ACA was used to assess patients' relative preferences for specific cytotoxic medication characteristics, and to estimate the percentage of women preferring cyclophosphamide over azathioprine for different risk-benefit scenarios. All participants were able to complete the conjoint task in 14 +/-5 minutes. Of the nine medication characteristics studied, efficacy and risk for infection had the greatest impact on preference (each accounting for 20% of the variation in preferences), suggesting that patients consider differences in the risk for infection equally as important as differences in the probability of renal survival. Premenopausal women wanting more children were less likely to choose cyclophosphamide compared with their counterparts (56% vs. 80%, P = 0.04). Modest changes in the probability of renal survival or risk for major toxicity lowered the percentage of women preferring cyclophosphamide by more than 20%, irrespective of their desire for more children. ACA is a feasible method of assessing how patients consider specific medication characteristics and predicting treatment preferences under different risk-benefit scenarios. ACA may be a valuable tool to incorporate patient preferences into medical decision-making. JF - Medical care AU - Fraenkel, L AU - Bodardus, S AU - Wittnik, D R AU - Wittink, D R AD - Department of Medicine, Yale University, New Haven, Connecticut 06520-8031, USA. liana.fraenkel@med.va.gov Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 1203 EP - 1216 VL - 39 IS - 11 SN - 0025-7079, 0025-7079 KW - Antirheumatic Agents KW - 0 KW - Cyclophosphamide KW - 8N3DW7272P KW - Azathioprine KW - MRK240IY2L KW - Index Medicus KW - Azathioprine -- adverse effects KW - Azathioprine -- therapeutic use KW - Humans KW - Decision Making KW - Connecticut KW - Cyclophosphamide -- adverse effects KW - Cyclophosphamide -- therapeutic use KW - Adult KW - Treatment Outcome KW - Least-Squares Analysis KW - Middle Aged KW - Female KW - Survival Analysis KW - Models, Theoretical KW - Patient Satisfaction -- statistics & numerical data KW - Lupus Nephritis -- drug therapy KW - Patient Participation KW - Antirheumatic Agents -- adverse effects KW - Risk Assessment -- methods KW - Antirheumatic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72210236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=Understanding+patient+preferences+for+the+treatment+of+lupus+nephritis+with+adaptive+conjoint+analysis.&rft.au=Fraenkel%2C+L%3BBodardus%2C+S%3BWittnik%2C+D+R%3BWittink%2C+D+R&rft.aulast=Fraenkel&rft.aufirst=L&rft.date=2001-11-01&rft.volume=39&rft.issue=11&rft.spage=1203&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=00257079&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-05 N1 - Date created - 2001-10-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Med Care. 2003 May;41(5):574 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy. AN - 72191056; 11595644 AB - Cubilin is a 460-kDa multipurpose, multidomain receptor that contains an NH(2)-terminal 110-residue segment followed by 8 epidermal growth factor (EGF)-like repeats and a contiguous stretch (representing nearly 88% of its mass) of 27 CUB (initially found in complement components C1r/C1s, Uegf, and bone morphogenic protein-1) domains. Cubilin binds to intrinsic factor (IF)-cobalamin (cbl, vitamin B(12)) complex and promotes the ileal transport of cbl. The 460-kDa form of cubilin is the predominant form present in the apical brush-border membranes of rat intestine, kidney, and yolk sac, but a 230-kDa form of cubilin is also noted in the intestinal membranes. In thyroidectomized (TDX) rats, levels of intestinal brush-border IF-[(57)Co]-labeled cbl binding, 460-kDa cubilin protein levels and tissue (kidney) accumulation of cbl were reduced by approximately 70%. Immunoblot analysis using cubilin antiserum of intestinal total membranes from TDX rats revealed cubilin fragments with molecular masses of 200 and 300 kDa. Both of these bands, along with the 230-kDa band detected in the total membranes of control rats and unlike the 460-kDa form, failed to react with antiserum to EGF. Mucosal membrane cubilin associated with megalin was reduced from approximately 12% in control to approximately 4% in TDX rats, and this decreased association was not due to altered megalin levels. Thyroxine treatment of TDX rats resulted in reversal of all of these effects, including an increase to nearly 24% of cubilin associated with megalin. In vitro, megalin binding to cubilin occurred with the NH(2)-terminal region that contained the EGF-like repeats and CUB domains 1 and 2 but not with a downstream region that contained CUB domains 2-10. These studies indicate that thyroxine deficiency in rats results in decreased uptake and tissue accumulation of cbl caused mainly by destabilization and deficit of cubilin in the intestinal brush border. JF - American journal of physiology. Endocrinology and metabolism AU - Yammani, R R AU - Seetharam, S AU - Seetharam, B AD - Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin and Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin, 53226, USA. Y1 - 2001/11// PY - 2001 DA - November 2001 SP - E900 EP - E907 VL - 281 IS - 5 SN - 0193-1849, 0193-1849 KW - Cobalt Radioisotopes KW - 0 KW - Low Density Lipoprotein Receptor-Related Protein-2 KW - Receptors, Cell Surface KW - intrinsic factor-cobalamin receptor KW - Intrinsic Factor KW - 9008-12-2 KW - Edetic Acid KW - 9G34HU7RV0 KW - Vitamin B 12 KW - P6YC3EG204 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats KW - Immunoblotting KW - Animals KW - Drug Interactions KW - Electrophoresis, Polyacrylamide Gel KW - Microvilli -- metabolism KW - Intrinsic Factor -- metabolism KW - Vitamin B 12 -- metabolism KW - Calcium -- pharmacology KW - Protein Binding KW - Edetic Acid -- pharmacology KW - Receptors, Cell Surface -- metabolism KW - Intestines -- ultrastructure KW - Thyroidectomy KW - Low Density Lipoprotein Receptor-Related Protein-2 -- metabolism KW - Receptors, Cell Surface -- analysis KW - Intestines -- chemistry KW - Low Density Lipoprotein Receptor-Related Protein-2 -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72191056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Endocrinology+and+metabolism&rft.atitle=Cubilin+and+megalin+expression+and+their+interaction+in+the+rat+intestine%3A+effect+of+thyroidectomy.&rft.au=Yammani%2C+R+R%3BSeetharam%2C+S%3BSeetharam%2C+B&rft.aulast=Yammani&rft.aufirst=R&rft.date=2001-11-01&rft.volume=281&rft.issue=5&rft.spage=E900&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Endocrinology+and+metabolism&rft.issn=01931849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial. AN - 71291889; 11895000 AB - Both replication-incompetent and replication-selective adenoviruses are being developed for the treatment of cancer and other diseases. Concerns have been raised about the safety of intra-vascular adenovirus administration following a patient death on a clinical trial with a replication-defective adenovirus. In addition, the feasibility of vascular delivery to distant tumors has been questioned. dl1520 (ONYX-015) is a replication-selective adenovirus that has previously shown safety and antitumoral activity following intratumoral injection. This is the first report of intra-vascular administration with a genetically engineered, replication-selective virus. A phase I dose-escalation trial was performed in patients with liver-predominant gastrointestinal carcinoma (n = 11 total; primarily colorectal). dl1520 was infused into the hepatic artery at doses of 2 x 10(8)-2 x 10(1)2 particles for two cycles (days 1 and 8). Subsequent cycles of dl1520 were administered in combination with intravenous 5-fluorouracil (5-FU) and leucovorin. No dose-limiting toxicity, maximally tolerated dose or treatment-emergent clinical hepatotoxicity were identified following dl1520 infusion. Mild to moderate fever, rigors and fatigue were the most common adverse events. Antibody titers increased significantly in all patients. Viral replication was detectable in patients receiving the highest two doses. An objective response was demonstrated in combination with chemotherapy in a patient who was refractory to both 5-FU and dl1520 as single agents. Therefore, hepatic artery infusion of the attenuated adenovirus dl1520 was well-tolerated at doses resulting in infection, replication and chemotherapy-associated antitumoral activity. JF - Gene therapy AU - Reid, T AU - Galanis, E AU - Abbruzzese, J AU - Sze, D AU - Andrews, J AU - Romel, L AU - Hatfield, M AU - Rubin, J AU - Kirn, D AD - Palo Alto Veterans Administration Hospital and Stanford University Medical Center, CA, USA. Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 1618 EP - 1626 VL - 8 IS - 21 SN - 0969-7128, 0969-7128 KW - Adenovirus E1B Proteins KW - 0 KW - Antibodies, Viral KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Infusions, Intra-Arterial KW - Hepatic Artery KW - Combined Modality Therapy KW - Leucovorin -- administration & dosage KW - Humans KW - Aged KW - Genome, Viral KW - Gene Deletion KW - Antibodies, Viral -- blood KW - Fluorouracil -- administration & dosage KW - Virus Replication -- genetics KW - Adenovirus E1B Proteins -- genetics KW - Middle Aged KW - Maximum Tolerated Dose KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Male KW - Female KW - Genetic Therapy -- adverse effects KW - Liver Neoplasms -- therapy KW - Liver Neoplasms -- drug therapy KW - Colorectal Neoplasms -- therapy KW - Colorectal Neoplasms -- immunology KW - Genetic Therapy -- methods KW - Liver Neoplasms -- secondary KW - Adenoviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71291889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+therapy&rft.atitle=Intra-arterial+administration+of+a+replication-selective+adenovirus+%28dl1520%29+in+patients+with+colorectal+carcinoma+metastatic+to+the+liver%3A+a+phase+I+trial.&rft.au=Reid%2C+T%3BGalanis%2C+E%3BAbbruzzese%2C+J%3BSze%2C+D%3BAndrews%2C+J%3BRomel%2C+L%3BHatfield%2C+M%3BRubin%2C+J%3BKirn%2C+D&rft.aulast=Reid&rft.aufirst=T&rft.date=2001-11-01&rft.volume=8&rft.issue=21&rft.spage=1618&rft.isbn=&rft.btitle=&rft.title=Gene+therapy&rft.issn=09697128&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-04-25 N1 - Date created - 2002-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of penicillin-binding protein 4 in expression of vancomycin resistance among clinical isolates of oxacillin-resistant Staphylococcus aureus AN - 18236307; 5294748 AB - It has been reported that penicillin-binding protein 4 (PBP4) activity decreases when a vancomycin-susceptible Staphylococcus aureus isolate is passaged in vitro to vancomycin resistance. We analyzed the PBP profiles of four vancomycin intermediately susceptible S. aureus (VISA) clinical isolates and found that PBP4 was undetectable in three isolates (HIP 5827, HIP 5836, and HIP 6297) and markedly reduced in a fourth (Mu50). PBP4 was readily visible in five vancomycin-susceptible, oxacillin-resistant S. aureus (ORSA) isolates. The nucleotide sequences of the pbp4 structural gene and flanking sequences did not different between the VISA and vancomycin-susceptible isolates. Overproduction of PBP4 on a high-copy-number plasmid in the VISA isolates produced a two- to threefold decrease in vancomycin MICs. Inactivation of pbp4 by allelic replacement mutagenesis in three vancomycin-susceptible ORSA strains (COL, RN450M, and N315) led to a decrease in vancomycin susceptibility, an increase in highly vancomycin-resistant subpopulations, and decreased cell wall cross-linking by high-performance liquid chromatography analysis. Complementation of the COL mutant with plasmid-encoded pbp4 restored the vancomycin MIC and increased cell wall cross-linking. These data suggest that alterations in PBP4 expression are at least partially responsible for the VISA phenotype. JF - Antimicrobial Agents & Chemotherapy AU - Finan, JE AU - Archer, G L AU - Pucci, MJ AU - Climo, M W AD - Hunter Holmes McGuire Veterans Affairs Medical Center, 1201 Broad Rock Blvd., Section 111-C, Richmond, VA 23249, USA, michael.climo@med.va.gov Y1 - 2001/11// PY - 2001 DA - Nov 2001 SP - 3070 EP - 3075 VL - 45 IS - 11 SN - 0066-4804, 0066-4804 KW - isolates KW - pbp4 gene KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Oxacillin KW - penicillin-binding protein KW - Minimum inhibitory concentration KW - Mutagenesis KW - Vancomycin KW - Staphylococcus aureus KW - Antibiotic resistance KW - Genetic code KW - A 01064:Microbial resistance KW - J 02787:Peptide and protein antibiotics KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18236307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Role+of+penicillin-binding+protein+4+in+expression+of+vancomycin+resistance+among+clinical+isolates+of+oxacillin-resistant+Staphylococcus+aureus&rft.au=Finan%2C+JE%3BArcher%2C+G+L%3BPucci%2C+MJ%3BClimo%2C+M+W&rft.aulast=Finan&rft.aufirst=JE&rft.date=2001-11-01&rft.volume=45&rft.issue=11&rft.spage=3070&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Staphylococcus aureus; Vancomycin; penicillin-binding protein; Antibiotic resistance; Oxacillin; Minimum inhibitory concentration; Mutagenesis; Genetic code ER - TY - JOUR T1 - Argon plasma coagulation for rectal bleeding after prostate brachytherapy AN - 18219341; 5292405 AB - Purpose: To better define the efficacy and safety of argon plasma coagulation (APC), specifically for brachytherapy-related proctitis, we reviewed the clinical course of 7 patients treated for persistent rectal bleeding. Approximately 2-10% of prostate cancer patients treated with super(125)I or super(103)Pd brachytherapy will develop radiation proctitis. The optimum treatment for patients with persistent bleeding is unclear from the paucity of available data. Prior reports lack specific dosimetric information, and patients with widely divergent forms of radiation were grouped together in the analyses. Methods and Materials: Seven patients were treated with APC at the Veterans Affairs Puget Sound Health Care System and the University of Washington from 1997 to 1999 for persistent rectal bleeding due to prostate brachytherapy-related proctitis. Four patients received supplemental external beam radiation, delivered by a four-field technique. A single gastroenterologist at the Veterans Affairs Puget Sound Health Care System treated 6 of the 7 patients. If the degree of proctitis was limited, all sites of active bleeding were coagulated in symptomatic patients. An argon plasma coagulator electrosurgical system was used to administer treatments every 4-8 weeks as needed. The argon gas flow was set at 1.6 L/min, with an electrical power setting of 40-45 W. Results: The rectal V100 (the total rectal volume, including the lumen, receiving the prescription dose or greater) for the 7 patients ranged from 0.13 to 4.61 cc. Rectal bleeding was first noticed 3-18 months after implantation. APC (range 1-3 sessions) was performed 9-22 months after implantation. Five patients had complete resolution of their bleeding, usually within days of completing APC. Two patients had only partial relief from bleeding, but declined additional APC therapy. No patient developed clinically evident progressive rectal wall abnormalities after APC, (post-APC follow-up range 4-13 months). Conclusions: Most patients benefited from APC, and no cases of clinically evident progressive tissue destruction were noted. Although APC appears to be efficacious and safe in the setting of the rectal doses described here, caution is in order when contemplating APC for brachytherapy patients. JF - International Journal of Radiation Oncology, Biology, & Physics AU - Smith, S AU - Wallner, K AU - Dominitz, JA AU - Han, B AU - True, L AU - Sutlief, S AU - Billingsley, K AD - Department of Radiation Oncology (#174), Puget Sound Health Care System, Department of Veterans Affairs, 1660 S. Columbian Way, Seattle, WA 98108-15971, USA, kent.wallner@med.va.gov Y1 - 2001/11/01/ PY - 2001 DA - 2001 Nov 01 SP - 636 EP - 642 PB - Elsevier Science Inc. VL - 51 IS - 3 SN - 0360-3016, 0360-3016 KW - man KW - argon KW - prostate cancer KW - Toxicology Abstracts KW - Rectum KW - Bleeding KW - Radiotherapy KW - Proctitis KW - Side effects KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18219341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.atitle=Argon+plasma+coagulation+for+rectal+bleeding+after+prostate+brachytherapy&rft.au=Smith%2C+S%3BWallner%2C+K%3BDominitz%2C+JA%3BHan%2C+B%3BTrue%2C+L%3BSutlief%2C+S%3BBillingsley%2C+K&rft.aulast=Smith&rft.aufirst=S&rft.date=2001-11-01&rft.volume=51&rft.issue=3&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Side effects; Bleeding; Rectum; Radiotherapy; Proctitis ER - TY - JOUR T1 - Mutational effects at the subunit interfaces of human hemoglobin: evidence for a unique sensitivity of the T quaternary state to changes in the hinge region of the alpha 1 beta 2 interface. AN - 72184808; 11591155 AB - A set of variant human hemoglobins, each with an Ala or Gly substitution at a single residue, has been prepared, and the kinetics of their reactions with carbon monoxide have been measured. This reaction is rate-limited by the binding of the first CO to the deoxygenated T state of the protein. The magnitudes of the effects of the mutations on CO combination vary widely, and, with the exception of beta Y145, the residues with the most significant effects on these kinetics are found in the hinge region of the alpha 1 beta 2 interface. Mixed-metal hybrids, with zinc protoporphyrin IX in place of heme on both alpha or both beta subunits, were prepared for beta W37E, beta W37A, alpha Y140G, and alpha Y140A, hinge region variants causing large kinetic changes, and for beta Y145G. Such hybrids permit measurements of the kinetics of CO binding to only the heme-containing alpha or beta subunits within the unliganded hemoglobin tetramer. Mutations at beta 37 and alpha 140 have global effects on the T state, increasing the rates of CO binding to both types of subunits. Mutation of beta Y145 has a large effect on the beta subunits in the deoxygenated T state, but very little effect on the alpha subunits. Oxygen equilibria measurements on the crystalline T state of beta W37E also indicate large affinity increases in both subunits of this variant. The overall oxygen equilibria of the variant hemoglobins in solution are sensitive to numerous variables besides the properties of the deoxygenated T state. In contrast to CO combination kinetics, the residues whose alterations cause the largest changes in overall oxygen equilibria in solution are scattered seemingly randomly within the alpha 1 beta 2 interface. JF - Biochemistry AU - Noble, R W AU - Hui, H L AU - Kwiatkowski, L D AU - Paily, P AU - DeYoung, A AU - Wierzba, A AU - Colby, J E AU - Bruno, S AU - Mozzarelli, A AD - Department of Medicine, University at Buffalo, Veterans Administration Medical Center, Buffalo, NY 14215, USA. rnoble@acsu.buffalo.edu Y1 - 2001/10/16/ PY - 2001 DA - 2001 Oct 16 SP - 12357 EP - 12368 VL - 40 IS - 41 SN - 0006-2960, 0006-2960 KW - Hemoglobins KW - 0 KW - Protein Subunits KW - Protoporphyrins KW - Recombinant Proteins KW - zinc protoporphyrin KW - 15442-64-5 KW - Carbon Monoxide KW - 7U1EE4V452 KW - Globins KW - 9004-22-2 KW - Hemoglobin A KW - 9034-51-9 KW - Iron KW - E1UOL152H7 KW - Zinc KW - J41CSQ7QDS KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Models, Molecular KW - Oxygen -- metabolism KW - Dimerization KW - Hemoglobin A -- chemistry KW - Humans KW - Globins -- genetics KW - Iron -- chemistry KW - Hemoglobin A -- metabolism KW - Recombinant Proteins -- genetics KW - Zinc -- chemistry KW - Globins -- chemistry KW - Protein Structure, Quaternary KW - Mutagenesis, Site-Directed KW - Recombinant Proteins -- metabolism KW - Kinetics KW - In Vitro Techniques KW - Recombinant Proteins -- chemistry KW - Carbon Monoxide -- metabolism KW - Globins -- metabolism KW - Hemoglobin A -- genetics KW - Protoporphyrins -- chemistry KW - Amino Acid Substitution KW - Hemoglobins -- metabolism KW - Hemoglobins -- genetics KW - Hemoglobins -- chemistry KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72184808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Mutational+effects+at+the+subunit+interfaces+of+human+hemoglobin%3A+evidence+for+a+unique+sensitivity+of+the+T+quaternary+state+to+changes+in+the+hinge+region+of+the+alpha+1+beta+2+interface.&rft.au=Noble%2C+R+W%3BHui%2C+H+L%3BKwiatkowski%2C+L+D%3BPaily%2C+P%3BDeYoung%2C+A%3BWierzba%2C+A%3BColby%2C+J+E%3BBruno%2C+S%3BMozzarelli%2C+A&rft.aulast=Noble&rft.aufirst=R&rft.date=2001-10-16&rft.volume=40&rft.issue=41&rft.spage=12357&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-11-01 N1 - Date created - 2001-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - SHP1 protein-tyrosine phosphatase inhibits gp91PHOX and p67PHOX expression by inhibiting interaction of PU.1, IRF1, interferon consensus sequence-binding protein, and CREB-binding protein with homologous Cis elements in the CYBB and NCF2 genes. AN - 72180450; 11483597 AB - The CYBB and NCF2 genes encode the phagocyte respiratory burst oxidase proteins, gp91PHOX and p67PHOX. Previously, we identified homologous CYBB and NCF2 cis elements that are necessary for lineage-specific transcription during late myeloid differentiation. We determined that these homologous cis elements are activated by PU.1, IRF1, interferon consensus sequence-binding protein (ICSBP), and the CREB-binding protein (CBP). Since expression of PU.1 and ICSBP is lineage-restricted, our investigations identified a mechanism of lineage-specific CYBB and NCF2 transcription. Since PU.1, IRF1, ICSBP, and CBP are expressed in undifferentiated myeloid cells, our investigations did not determine the mechanism of differentiation stage-specific CYBB and NCF2 transcription. In the current investigations, we determine that SHP1 protein-tyrosine phosphatase (SHP1-PTP) inhibits gp91PHOX and p67PHOX expression, in undifferentiated myeloid cell lines, by decreasing interaction of PU.1, IRF1, ICSBP, and CBP with the CYBB and NCF2 genes. We also determine that IRF1 and ICSBP are tyrosine-phosphorylated during interferon gamma differentiation of myeloid cell lines, and we identify IRF1 and ICSBP tyrosine residues that are necessary for CYBB and NCF2 transcription. Therefore, these investigations identify a novel mechanism by which SHP1-PTP antagonizes myeloid differentiation and determine that tyrosine phosphorylation of IRF1 and ICSPB mediates stage-specific transcriptional activation in differentiating myeloid cells. JF - The Journal of biological chemistry AU - Kautz, B AU - Kakar, R AU - David, E AU - Eklund, E A AD - Department of Medicine, Northwestern University Medical School and The Robert H. Lurie Comprehensive Cancer Center, Chicago Lakeside Veterans Administration Hospital, Chicago, Illinois 60611, USA. Y1 - 2001/10/12/ PY - 2001 DA - 2001 Oct 12 SP - 37868 EP - 37878 VL - 276 IS - 41 SN - 0021-9258, 0021-9258 KW - CYBB protein, human KW - 0 KW - DNA Primers KW - Membrane Glycoproteins KW - Phosphoproteins KW - RNA, Messenger KW - Transcription Factors KW - neutrophil cytosol factor 67K KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Gene Expression Regulation, Enzymologic KW - Phosphorylation KW - Humans KW - Transcription, Genetic KW - RNA, Messenger -- genetics KW - Protein Binding KW - U937 Cells KW - Phosphoproteins -- genetics KW - Transcription Factors -- antagonists & inhibitors KW - Transcription Factors -- metabolism KW - Membrane Glycoproteins -- antagonists & inhibitors KW - Phosphoproteins -- antagonists & inhibitors KW - Phosphoproteins -- metabolism KW - Membrane Glycoproteins -- metabolism KW - Membrane Glycoproteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72180450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=SHP1+protein-tyrosine+phosphatase+inhibits+gp91PHOX+and+p67PHOX+expression+by+inhibiting+interaction+of+PU.1%2C+IRF1%2C+interferon+consensus+sequence-binding+protein%2C+and+CREB-binding+protein+with+homologous+Cis+elements+in+the+CYBB+and+NCF2+genes.&rft.au=Kautz%2C+B%3BKakar%2C+R%3BDavid%2C+E%3BEklund%2C+E+A&rft.aulast=Kautz&rft.aufirst=B&rft.date=2001-10-12&rft.volume=276&rft.issue=41&rft.spage=37868&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-10-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - MD-2 Binds to Bacterial Lipopolysaccharide AN - 18104976; 5185458 AB - The exact roles and abilities of the individual components of the lipopolysaccharide (LPS) receptor complex of proteins remain unclear. MD-2 is a molecule found in association with toll-like receptor 4. We produced recombinant human MD-2 to explore its LPS binding ability and role in the LPS receptor complex. MD-2 binds to highly purified rough LPS derived from Salmonella minnesota and Escherichia coli in five different assays; one assay yielded an apparent K sub(D) of 65 nM. MD-2 binding to LPS did not require LPS-binding proteins LBP and CD14; in fact LBP competed with MD-2 for LPS. MD-2 enhanced the biological activity of LPS in toll-like receptor 4-transfected Chinese hamster ovary cells but inhibited LPS activation of U373 astrocytoma cells and of monocytes in human whole blood. These data indicate that MD-2 is a genuine LPS-binding protein and strongly suggest that MD-2 could play a role in regulation of cellular activation by LPS depending on its local availability. JF - Journal of Biological Chemistry AU - Viriyakosol, S AU - Tobias, P S AU - Kitchens, R L AU - Kirkland, T N AD - Veterans Administration San Diego Healthcare System, University of California San Diego, San Diego, California 92161, USA, sviriyak@ucsd.edu Y1 - 2001/10/12/ PY - 2001 DA - 2001 Oct 12 SP - 38044 EP - 38051 VL - 276 IS - 41 SN - 0021-9258, 0021-9258 KW - binding KW - man KW - MD-2 KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - Endotoxins KW - Salmonella minnesota KW - Lipopolysaccharides KW - X 24171:Microbial KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18104976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=MD-2+Binds+to+Bacterial+Lipopolysaccharide&rft.au=Viriyakosol%2C+S%3BTobias%2C+P+S%3BKitchens%2C+R+L%3BKirkland%2C+T+N&rft.aulast=Viriyakosol&rft.aufirst=S&rft.date=2001-10-12&rft.volume=276&rft.issue=41&rft.spage=38044&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Salmonella minnesota; Lipopolysaccharides; Endotoxins ER - TY - JOUR T1 - Comparison of Language Impairment, Functional Communication, and Discourse Measures in African-American Aphasic and Normal Adults AN - 85539589; 200203364 AB - We compared performance on language impairment, functional communication, & discourse measures between 33 African American aphasic patients & 30 African American normal Ss. The aphasic group performed significantly lower than the normal group on the Western Aphasia Battery Aphasia & Cortical Quotients, Token Test, & ASHA Functional Assessment of Communication Skills for Adults. Moreover, the aphasic group performed significantly lower than the normal group in their quality of language on a discourse task that required telling a frightening experience. Significant relationships between performance on the measures were confined to those that index language impairment. Use of a normal ethnic cohort for comparison with African American aphasic performance may control for potential ethnic bias in the measures. In addition, use of a discourse task permits observation of grammatical & stylistic features in African American English that may not be captured or are ignored by traditional language impairment & functional communication measures. 5 Tables, 1 Appendix, 29 References. Adapted from the source document JF - Aphasiology AU - Ulatowska, Hanna K AU - Olness, Gloria S AU - Wertz, Robert T AU - Thompson, Jennifer L AU - Keebler, Molly W AU - Hill, CaSaundra L AU - Auther, Linda L AD - c/o Wertz-Audiology & Speech Pathology, VA Medical Center, South Nashville, TN robert.wertz@med.va.gov Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 1007 EP - 1016 VL - 15 IS - 10-11 SN - 0268-7038, 0268-7038 KW - Language Tests (44250) KW - Language Therapy (44400) KW - Speech Tests (83100) KW - Aphasia (03400) KW - Story Telling (84400) KW - Black Americans (09100) KW - Verbal Tasks (93800) KW - Measures (Instruments) (52300) KW - Speech Production (82780) KW - Black English (09150) KW - article KW - 6812: special education; language therapy KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85539589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Comparison+of+Language+Impairment%2C+Functional+Communication%2C+and+Discourse+Measures+in+African-American+Aphasic+and+Normal+Adults&rft.au=Ulatowska%2C+Hanna+K%3BOlness%2C+Gloria+S%3BWertz%2C+Robert+T%3BThompson%2C+Jennifer+L%3BKeebler%2C+Molly+W%3BHill%2C+CaSaundra+L%3BAuther%2C+Linda+L&rft.aulast=Ulatowska&rft.aufirst=Hanna&rft.date=2001-10-01&rft.volume=15&rft.issue=10-11&rft.spage=1007&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Black Americans (09100); Language Tests (44250); Measures (Instruments) (52300); Speech Production (82780); Verbal Tasks (93800); Speech Tests (83100); Black English (09150); Story Telling (84400); Language Therapy (44400) ER - TY - JOUR T1 - Pott's puffy tumor and epidural abscess arising from dental sepsis: a case report. AN - 85366993; pmid-11801935 AB - To present an unusual case of two uncommon cranial complications of frontal sinusitis: Pott's puffy tumor and epidural abscess arising from frontal sinusitis of dental origin, and also two systemic complications of sinusitis: septicemia and empyema, all occurring in an immunocompetent patient.A 21-year-old man presented with a scalp swelling and epidural abscess. Magnetic resonance imaging and computed tomographic scans revealed unilateral opacification of the frontal sinus and an epidural abscess with a direct connection to the scalp abscess. Further history revealed that his symptoms occurred coincidentally with a tooth extraction 2 months before, and he was hospitalized soon after the tooth extraction for sepsis and a lung abscess.A combined neurosurgical and otolaryngologic approach was required to treat the sinusitis and the associated epidural and scalp abscess.Cultures returned as Streptococcus intermedius from all three sites. The patient was free of disease at the 3-month follow-up.Odontogenic maxillary sinusitis is well documented; however, there is little reported of frontal sinusitis arising from dental disease. The prevalence of sinusitis of dental origin will be reviewed, including the microbiology of this particularly virulent organism that persisted despite earlier treatment with ampicillin. Also, the current thoughts on management of these cases will be discussed with particular reference to local therapy for sinusitis in addition to systemic treatment with antibiotics. JF - The Laryngoscope AU - Chandy, B AU - Todd, J AU - Stucker, F J AU - Nathan, C A AD - Department of Otolaryngology/Head & Neck Surgery, Louisiana State University Health Science Center, the Veterans Administration Shreveport, 71130, USA. Y1 - 2001/10// PY - 2001 DA - Oct 2001 SP - 1732 EP - 1734 VL - 111 IS - 10 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Abscess: diagnosis KW - *Abscess: etiology KW - Abscess: surgery KW - Adult KW - Diagnosis, Differential KW - Empyema, Pleural: diagnosis KW - Empyema, Pleural: etiology KW - Empyema, Pleural: surgery KW - Epidural Abscess: diagnosis KW - *Epidural Abscess: etiology KW - Epidural Abscess: surgery KW - Frontal Sinusitis: diagnosis KW - *Frontal Sinusitis: etiology KW - Frontal Sinusitis: surgery KW - Humans KW - Magnetic Resonance Imaging KW - Male KW - Patient Care Team KW - *Periapical Abscess: surgery KW - Postoperative Complications: diagnosis KW - *Postoperative Complications: etiology KW - Postoperative Complications: surgery KW - Reoperation KW - Scalp: pathology KW - Scalp: surgery KW - Sepsis: diagnosis KW - Sepsis: etiology KW - Sepsis: surgery KW - Streptococcal Infections: diagnosis KW - *Streptococcal Infections: etiology KW - Streptococcal Infections: surgery KW - *Tooth Extraction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85366993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Pott%27s+puffy+tumor+and+epidural+abscess+arising+from+dental+sepsis%3A+a+case+report.&rft.au=Chandy%2C+B%3BTodd%2C+J%3BStucker%2C+F+J%3BNathan%2C+C+A&rft.aulast=Chandy&rft.aufirst=B&rft.date=2001-10-01&rft.volume=111&rft.issue=10&rft.spage=1732&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Kaposi's sarcoma and cytomegaloviral ileocolitis complicating long-standing Crohn's disease in an HIV-negative patient. AN - 85364203; pmid-11693345 AB - A 67-yr-old woman with a 25-yr history of Crohn's disease, maintained on near-continuous corticosteroids (prednisone 10 mg daily) over a 6-yr period, underwent ileocolic resection for obstruction. Pathology revealed Crohn's disease, multiple nodules of Kaposi's sarcoma, and cytomegalic inclusion bodies with confirmation of cytomegalovirus by shell vial immunofluorescence. Testing for HIV serum antibody has been repeatedly negative. Crohn's disease, Kaposi's sarcoma, and cytomegalovirus have been clinically in remission for 5 yr. JF - The American journal of gastroenterology AU - Cohen, R L AU - Tepper, R E AU - Urmacher, C AU - Katz, S AD - Department of Medicine, Veterans Administration Medical Center, New York, New York, USA. Y1 - 2001/10// PY - 2001 DA - Oct 2001 SP - 3028 EP - 3031 VL - 96 IS - 10 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Anti-Inflammatory Agents: therapeutic use KW - *Crohn Disease: complications KW - Crohn Disease: diagnosis KW - *Crohn Disease: drug therapy KW - *Cytomegalovirus Infections: complications KW - Cytomegalovirus Infections: diagnosis KW - Female KW - Glucocorticoids: therapeutic use KW - HIV Seronegativity KW - Humans KW - Prednisone: therapeutic use KW - *Sarcoma, Kaposi: complications KW - Sarcoma, Kaposi: diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85364203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Kaposi%27s+sarcoma+and+cytomegaloviral+ileocolitis+complicating+long-standing+Crohn%27s+disease+in+an+HIV-negative+patient.&rft.au=Cohen%2C+R+L%3BTepper%2C+R+E%3BUrmacher%2C+C%3BKatz%2C+S&rft.aulast=Cohen&rft.aufirst=R&rft.date=2001-10-01&rft.volume=96&rft.issue=10&rft.spage=3028&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Ciprofloxacin microprecipitates and macroprecipitates in the human corneal epithelium. AN - 72254156; 11687375 AB - In 4 corneal transplantation patients treated preoperatively with ciprofloxacin ophthalmic drops, microprecipitates associated with damaged corneal epithelium were noted in 2 patients. Another patient developed a large macroprecipitate in a corneal ulcer. All specimens were examined by electron microscopy and high-pressure liquid chromatography. The crystalline precipitates were pure ciprofloxacin. The macroprecipitate demonstrated a large zone of inhibition on agar plates seeded with a susceptible organism at 24 and 48 hours. It was bioactive and bioavailable in vitro. JF - Journal of cataract and refractive surgery AU - Eiferman, R A AU - Snyder, J P AU - Nordquist, R E AD - Research Service, Veterans Administration Medical Center, Louisville, Kentucky, USA. reiferman@cs.com Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 1701 EP - 1702 VL - 27 IS - 10 SN - 0886-3350, 0886-3350 KW - Anti-Infective Agents KW - 0 KW - Ophthalmic Solutions KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Index Medicus KW - Humans KW - Chemical Precipitation KW - Aged KW - Female KW - Chromatography, High Pressure Liquid KW - Microscopy, Electron, Scanning KW - Corneal Transplantation KW - Anti-Infective Agents -- adverse effects KW - Epithelium, Corneal -- drug effects KW - Corneal Ulcer -- chemically induced KW - Corneal Ulcer -- pathology KW - Ciprofloxacin -- adverse effects KW - Antibiotic Prophylaxis KW - Epithelium, Corneal -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72254156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cataract+and+refractive+surgery&rft.atitle=Ciprofloxacin+microprecipitates+and+macroprecipitates+in+the+human+corneal+epithelium.&rft.au=Eiferman%2C+R+A%3BSnyder%2C+J+P%3BNordquist%2C+R+E&rft.aulast=Eiferman&rft.aufirst=R&rft.date=2001-10-01&rft.volume=27&rft.issue=10&rft.spage=1701&rft.isbn=&rft.btitle=&rft.title=Journal+of+cataract+and+refractive+surgery&rft.issn=08863350&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-07 N1 - Date created - 2001-11-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Cataract Refract Surg. 2002 Jun;28(6):909; author reply 909 [12036608] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of the reactive oxygen species hydrogen peroxide and hypochlorite on endothelial nitric oxide production. AN - 72216851; 11641302 AB - Reactive oxygen species (ROS) hydrogen peroxide (H(2)O(2)) and hypochlorite (HOCl) participate in the pathogenesis of ischemia/reperfusion injury, inflammation, and atherosclerosis. Both NO and ROS are important modulators of vascular tone and architecture and of adhesive interactions between leukocytes, platelets, and vascular endothelium. We studied the effect of H(2)O(2) and HOCl on receptor-dependent (bradykinin [10(-6) mol/L] and ADP [10(-4) mol/L]) and receptor-independent mechanisms (calcium ionophore A23187 [10(-6) mol/L]) of NO production by porcine aortic endothelial cells (ECs). Changes in the level of EC cGMP (the second messenger of NO) were used as a surrogate of NO production. EC cGMP increased 300% in response to bradykinin and A23187 and 200% in response to ADP. Exposure of ECs to H(2)O(2) (50 micromol/L) for 30 minutes significantly impaired cGMP levels in response to ADP, bradykinin, and the receptor-independent NO agonist A23187. In contrast, preincubation with HOCl (50 micromol/L) impaired cGMP production only in response to ADP and bradykinin but not A23187. These concentrations of H(2)O(2) and HOCl did not result in increased EC lethality as assessed by lactate dehydrogenase release. Neither H(2)O(2) nor HOCl affected EC cGMP production in response to NO donor sodium nitroprusside, which suggests that guanylate cyclase is resistant to these oxidants. We also demonstrated that neither H(2)O(2) nor HOCl affects endothelial NO synthase (eNOS) catalytic activity as measured by conversion of L-arginine to L-citrulline in EC homogenates supplemented with eNOS cofactors. The present studies show that H(2)O(2) impairs NO production in response to both receptor-dependent and receptor-independent agonists and that these effects are due, at least in part, to inactivation of eNOS cofactors, whereas HOCl inhibits NO production by interfering with receptor-operated mechanisms at the level of the cell membrane. Concentrations of H(2)O(2) and HOCl used in the present studies have been shown to be generated in vivo during inflammation and ischemia/reperfusion. Therefore, we infer that these effects of H(2)O(2) and HOCl on EC NO production may contribute to disregulated vascular tone and altered leukocyte-EC interactions that occur in vascular injury as a result of those causes in which ROS generation is involved. JF - Hypertension (Dallas, Tex. : 1979) AU - Jaimes, E A AU - Sweeney, C AU - Raij, L AD - Nephrology and Hypertension Section, Veterans Administration Medical Center, Minneapolis, Minnesota, USA. Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 877 EP - 883 VL - 38 IS - 4 KW - Enzyme Inhibitors KW - 0 KW - Oxidants KW - Nitroprusside KW - 169D1260KM KW - omega-N-Methylarginine KW - 27JT06E6GR KW - Nitric Oxide KW - 31C4KY9ESH KW - Calcimycin KW - 37H9VM9WZL KW - Adenosine Diphosphate KW - 61D2G4IYVH KW - Hypochlorous Acid KW - 712K4CDC10 KW - Arginine KW - 94ZLA3W45F KW - Hydrogen Peroxide KW - BBX060AN9V KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Nitric Oxide Synthase Type III KW - Cyclic GMP KW - H2D2X058MU KW - Bradykinin KW - S8TIM42R2W KW - Index Medicus KW - Swine KW - Animals KW - Adenosine Diphosphate -- pharmacology KW - Calcimycin -- pharmacology KW - Arginine -- pharmacology KW - Cyclic GMP -- metabolism KW - Cells, Cultured KW - Nitric Oxide Synthase -- antagonists & inhibitors KW - Enzyme Inhibitors -- pharmacology KW - omega-N-Methylarginine -- pharmacology KW - Bradykinin -- pharmacology KW - Nitroprusside -- pharmacology KW - Nitric Oxide Synthase -- metabolism KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Oxidants -- pharmacology KW - Endothelium, Vascular -- cytology KW - Hypochlorous Acid -- pharmacology KW - Hydrogen Peroxide -- pharmacology KW - Nitric Oxide -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72216851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Effects+of+the+reactive+oxygen+species+hydrogen+peroxide+and+hypochlorite+on+endothelial+nitric+oxide+production.&rft.au=Jaimes%2C+E+A%3BSweeney%2C+C%3BRaij%2C+L&rft.aulast=Jaimes&rft.aufirst=E&rft.date=2001-10-01&rft.volume=38&rft.issue=4&rft.spage=877&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=1524-4563&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-11-01 N1 - Date created - 2001-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Parallel increases in lipid and protein oxidative markers in several mouse brain regions after methamphetamine treatment. AN - 72191203; 11595767 AB - The neurotoxic actions of methamphetamine (METH) may be mediated in part by reactive oxygen species (ROS). Methamphetamine administration leads to increases in ROS formation and lipid peroxidation in rodent brain; however, the extent to which proteins may be modified or whether affected brain regions exhibit similar elevations of lipid and protein oxidative markers have not been investigated. In this study we measured concentrations of TBARs, protein carbonyls and monoamines in various mouse brain regions at 4 h and 24 h after the last of four injections of METH (10 mg/kg/injection q 2 h). Substantial increases in TBARs and protein carbonyls were observed in the striatum and hippocampus but not the frontal cortex nor the cerebellum of METH-treated mice. Furthermore, lipid and protein oxidative markers were highly correlated within each brain region. In the hippocampus and striatum elevations in oxidative markers were significantly greater at 24 h than at 4 h. Monoamine levels were maximally reduced within 4 h (striatal dopamine [DA] by 95% and serotonin [5-HT] in striatum, cortex and hippocampus by 60-90%). These decrements persisted for 7 days after METH, indicating effects reflective of nerve terminal damage. Interestingly, NE was only transiently depleted in the brain regions investigated (hippocampus and cortex), suggesting a pharmacological and non-toxic action of METH on the noradrenergic nerve terminals. This study provides the first evidence for concurrent formation of lipid and protein markers of oxidative stress in several brain regions of mice that are severely affected by large neurotoxic doses of METH. Moreover, the differential time course for monoamine depletion and the elevations in oxidative markers indicate that the source of oxidative stress is not derived directly from DA or 5HT oxidation. JF - Journal of neurochemistry AU - Gluck, M R AU - Moy, L Y AU - Jayatilleke, E AU - Hogan, K A AU - Manzino, L AU - Sonsalla, P K AD - Department of Neurology, Bronx Veterans Medical CenterBronx, New York, USA. gluck.martin@bronx.va.gov Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 152 EP - 160 VL - 79 IS - 1 SN - 0022-3042, 0022-3042 KW - Biogenic Monoamines KW - 0 KW - Biomarkers KW - Nerve Tissue Proteins KW - Reactive Oxygen Species KW - Thiobarbituric Acid Reactive Substances KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - Serotonin KW - 333DO1RDJY KW - Methamphetamine KW - 44RAL3456C KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Cerebral Cortex -- drug effects KW - Cerebral Cortex -- metabolism KW - Hydroxyindoleacetic Acid -- metabolism KW - Corpus Striatum -- metabolism KW - Hippocampus -- metabolism KW - Thiobarbituric Acid Reactive Substances -- analysis KW - Dopamine -- metabolism KW - Mice KW - Biogenic Monoamines -- metabolism KW - Cerebellum -- metabolism KW - Hippocampus -- drug effects KW - Oxidation-Reduction KW - 3,4-Dihydroxyphenylacetic Acid -- metabolism KW - Cerebellum -- drug effects KW - Oxidative Stress KW - Corpus Striatum -- drug effects KW - Serotonin -- metabolism KW - Male KW - Brain -- drug effects KW - Biomarkers -- analysis KW - Methamphetamine -- pharmacology KW - Nerve Tissue Proteins -- metabolism KW - Brain -- metabolism KW - Lipid Peroxidation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72191203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Parallel+increases+in+lipid+and+protein+oxidative+markers+in+several+mouse+brain+regions+after+methamphetamine+treatment.&rft.au=Gluck%2C+M+R%3BMoy%2C+L+Y%3BJayatilleke%2C+E%3BHogan%2C+K+A%3BManzino%2C+L%3BSonsalla%2C+P+K&rft.aulast=Gluck&rft.aufirst=M&rft.date=2001-10-01&rft.volume=79&rft.issue=1&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of base in the treatment of severe acidemic states. AN - 71208791; 11576874 AB - Severe acidemia (blood pH < 7.1 to 7.2) suppresses myocardial contractility, predisposes to cardiac arrhythmias, causes venoconstriction, and can decrease total peripheral vascular resistance and blood pressure, reduce hepatic blood flow, and impair oxygen delivery. These alterations in organ function can contribute to increased morbidity and mortality. Although it seemed logical to administer sodium bicarbonate to attenuate acidemia and therefore lessen the impact on cardiac function, the routine use of bicarbonate in the treatment of the most common causes of severe acidemia, diabetic ketoacidosis, lactic acidosis, and cardiac arrest, has been an issue of great controversy. Studies of animals and patients with these disorders have reported conflicting data on the benefits of bicarbonate, showing both beneficial and detrimental effects. Alternative alkalinizing agents, tris-hydroxymethyl aminomethane and Carbicarb, have shown some promise in studies of animals and humans, and reevaluation of these buffers in the treatment of severe acidemic states seems warranted. The potential value of base therapy in the treatment of severe acidemia remains an important issue, and further studies are required to determine which patients should be administered base therapy and what base should be used. JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Kraut, J A AU - Kurtz, I AD - Division of Nephrology, Veterans Administration Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA. jkraut@ucla.edu Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 703 EP - 727 VL - 38 IS - 4 KW - Bicarbonates KW - 0 KW - Buffers KW - Carbonates KW - Drug Combinations KW - sodium bicarbonate, sodium carbonate drug combination KW - Tromethamine KW - 023C2WHX2V KW - Sodium Bicarbonate KW - 8MDF5V39QO KW - Potassium KW - RWP5GA015D KW - Oxygen KW - S88TT14065 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Acidosis, Lactic -- drug therapy KW - Arrhythmias, Cardiac -- etiology KW - Vascular Resistance KW - Acidosis, Lactic -- etiology KW - Diabetic Ketoacidosis -- drug therapy KW - Oxygen -- metabolism KW - Humans KW - Carbonates -- therapeutic use KW - Cardiac Output -- drug effects KW - Potassium -- metabolism KW - Heart Arrest -- drug therapy KW - Calcium -- metabolism KW - Myocardial Contraction KW - Acidosis, Lactic -- complications KW - Tromethamine -- therapeutic use KW - Heart Arrest -- complications KW - Water-Electrolyte Balance -- physiology KW - Sodium Bicarbonate -- adverse effects KW - Acidosis -- therapy KW - Acidosis -- blood KW - Sodium Bicarbonate -- therapeutic use KW - Bicarbonates -- metabolism KW - Acidosis -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71208791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Use+of+base+in+the+treatment+of+severe+acidemic+states.&rft.au=Kraut%2C+J+A%3BKurtz%2C+I&rft.aulast=Kraut&rft.aufirst=J&rft.date=2001-10-01&rft.volume=38&rft.issue=4&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=1523-6838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-18 N1 - Date created - 2001-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Kidney Dis. 2002 May;39(5):1125-6; discussion 1126 [11979362] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic fatigue and sexual dysfunction in female Gulf War veterans. AN - 71165831; 11554210 AB - Chronic fatigue (CF) is one of the most common conditions reported by Gulf War veterans. This study evaluated female sexual dysfunction (FSD) in veterans with or without complaints of CF. Subjects were screened for medical and psychiatric causes of CF. They included 22 healthy subjects and 26 with fatiguing symptoms. FSD was reported by 10% of controls and by 60% of the fatigued (p < .002) while 19% versus 81% (p < .001) noted decreased libido. FSD was more prevalent in fatigued veterans than in the controls. This relationship was not mediated by an Axis I diagnosis. This appears to be the first report of sexual dysfunction in CF. JF - Journal of sex & marital therapy AU - Gilhooly, P E AU - Ottenweller, J E AU - Lange, G AU - Tiersky, L AU - Natelson, B H AD - Veterans Administration, New Jersey Health Care System, 385 Tremont Avenue, East Orange, NJ 07018, USA. PEGMD6@aol.com PY - 2001 SP - 483 EP - 487 VL - 27 IS - 5 SN - 0092-623X, 0092-623X KW - Index Medicus KW - Severity of Illness Index KW - Vagina -- physiopathology KW - Sexual Dysfunctions, Psychological -- epidemiology KW - Sexual Dysfunctions, Psychological -- diagnosis KW - Humans KW - Adult KW - Sexual Dysfunctions, Psychological -- physiopathology KW - Female KW - Prevalence KW - Fatigue Syndrome, Chronic -- diagnosis KW - Veterans -- psychology KW - Persian Gulf Syndrome -- psychology KW - Fatigue Syndrome, Chronic -- psychology KW - Fatigue Syndrome, Chronic -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71165831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+sex+%26+marital+therapy&rft.atitle=Chronic+fatigue+and+sexual+dysfunction+in+female+Gulf+War+veterans.&rft.au=Gilhooly%2C+P+E%3BOttenweller%2C+J+E%3BLange%2C+G%3BTiersky%2C+L%3BNatelson%2C+B+H&rft.aulast=Gilhooly&rft.aufirst=P&rft.date=2001-10-01&rft.volume=27&rft.issue=5&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Journal+of+sex+%26+marital+therapy&rft.issn=0092623X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-07 N1 - Date created - 2001-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - "Transcend": Initial Outcomes from a Posttraumatic Stress Disorder/Substance Abuse Treatment Program AN - 61507578; 200203304 AB - This paper describes the development of a comprehensive treatment program for combat veterans diagnosed with posttraumatic stress disorder (PTSD) & substance abuse (SA). Outcome data are presented on 46 male patients who completed treatment between 1996 & 1998. The treatment approach, defined by a detailed manual, integrates elements of cognitive-behavioral skills training, constructivist theory approaches, SA relapse prevention strategies, & peer social support into a group-focused program. The Clinician-Administered PTSD Scale (CAPS) & the Addiction Severity Index (ASI) were used to assess treatment effectiveness at discharge & 6- & 12-month follow-up. Significant symptom changes revealed on CAPS & ASI scores at discharge & follow-up are analyzed. Discussion focuses on hypotheses regarding treatment effectiveness, study limitations, & suggestions for further research. 2 Tables, 68 References. Adapted from the source document. JF - Journal of Traumatic Stress AU - Donovan, Beverly AU - Padin-Rivera, Edgardo AU - Kowaliw, Sean AD - Louis Stokes Cleveland Veterans Affairs Medical Center, Brecksville, OH beverly.donovan@med.va.gov Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 757 EP - 772 VL - 14 IS - 4 SN - 0894-9867, 0894-9867 KW - Veterans KW - Treatment Outcomes KW - Substance Abuse KW - Treatment Programs KW - Males KW - Cleveland, Ohio KW - Posttraumatic Stress Disorder KW - article KW - 6129: addiction KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61507578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Traumatic+Stress&rft.atitle=%22Transcend%22%3A+Initial+Outcomes+from+a+Posttraumatic+Stress+Disorder%2FSubstance+Abuse+Treatment+Program&rft.au=Donovan%2C+Beverly%3BPadin-Rivera%2C+Edgardo%3BKowaliw%2C+Sean&rft.aulast=Donovan&rft.aufirst=Beverly&rft.date=2001-10-01&rft.volume=14&rft.issue=4&rft.spage=757&rft.isbn=&rft.btitle=&rft.title=Journal+of+Traumatic+Stress&rft.issn=08949867&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JTSTEB N1 - SubjectsTermNotLitGenreText - Treatment Programs; Veterans; Posttraumatic Stress Disorder; Substance Abuse; Treatment Outcomes; Males; Cleveland, Ohio ER - TY - JOUR T1 - Characteristics of patients with gaze-evoked tinnitus. AN - 85357796; pmid-11568674 AB - The authors describe symptoms and population characteristics in subjects who can modulate the loudness and/or pitch of their tinnitus by eye movements.Data were obtained by questionnaire.The study was conducted at a university center and a tertiary care center.Respondents had the self-reported ability to modulate their tinnitus with eye movements.Ninety-one subjects reported having gaze-evoked tinnitus after posterior fossa surgery involving the eighth nerve. Eighty-seven of them underwent removal of a vestibular schwannoma (acoustic neuroma), two had bilateral eighth nerve tumors (one underwent bilateral tumor removal; the other unilateral tumor removal), one underwent removal of a cholesteatoma, and one underwent removal of a glomus jugulare tumor. Seventeen subjects who had never had posterior fossa surgery reported gaze-evoked tinnitus. Of those with vestibular schwannomas, tumor size ranged from small (4 cm). The gender distribution was 48.3% male and 51.7% female. In 77% of patients, the gaze-evoked tinnitus was localized to the surgical ear or side of head; 21.8% had bilateral tinnitus that was louder in the surgical ear or side of head. In 86 of 87 subjects, loudness of tinnitus changed with eye movement. Eye movement away from the central (eyes centered) position increased the loudness of tinnitus in all 86 subjects who responded to this question. Seventy-three of 85 (85.9%) patients indicated that pitch changed with eye movement, with pitch increasing in 64/72 (88.9%) of them. Eighty-three of 87 (95.4%) patients reported total loss of hearing in the surgical ear. Seventy of 83 (84.3%) patients reported facial nerve problems immediately after surgery, 52 of 87 (60%) reported persistent facial weakness, and 16 of 87 (18.4%) patients reported persistent double vision. In those 17 subjects with gaze-evoked tinnitus and no posterior fossa surgery, the majority of respondents (14/17, 82.4%) were male.Gaze-evoked tinnitus after cerebellar pontine angle surgery is more common than was previously believed. In addition, posterior fossa surgery is not a prerequisite for the development of gaze-evoked tinnitus. It is likely that gaze-evoked tinnitus is a manifestation of functional reorganization. Gaze-evoked tinnitus could result from an unmasking of brain regions that respond to multiple stimulus/response modalities, and/or from anomalous cross-modality interactions, perhaps caused by collateral sprouting. JF - Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology AU - Coad, M L AU - Lockwood, A AU - Salvi, R AU - Burkard, R AD - Veterans Administration Western New York Healthcare System, and Department of Neurology, University at Buffalo, Buffalo, New York 14214, USA. Y1 - 2001/09// PY - 2001 DA - Sep 2001 SP - 650 EP - 654 VL - 22 IS - 5 SN - 1531-7129, 1531-7129 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Cerebellopontine Angle: blood supply KW - Cerebellopontine Angle: surgery KW - Cochlear Nerve: surgery KW - Female KW - *Fixation, Ocular: physiology KW - Humans KW - Male KW - Middle Aged KW - Postoperative Period KW - Questionnaires KW - *Saccades: physiology KW - Severity of Illness Index KW - Tinnitus: diagnosis KW - *Tinnitus: etiology KW - Tomography, Emission-Computed UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85357796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otology+%26+neurotology+%3A+official+publication+of+the+American+Otological+Society%2C+American+Neurotology+Society+%5Band%5D+European+Academy+of+Otology+and+Neurotology&rft.atitle=Characteristics+of+patients+with+gaze-evoked+tinnitus.&rft.au=Coad%2C+M+L%3BLockwood%2C+A%3BSalvi%2C+R%3BBurkard%2C+R&rft.aulast=Coad&rft.aufirst=M&rft.date=2001-09-01&rft.volume=22&rft.issue=5&rft.spage=650&rft.isbn=&rft.btitle=&rft.title=Otology+%26+neurotology+%3A+official+publication+of+the+American+Otological+Society%2C+American+Neurotology+Society+%5Band%5D+European+Academy+of+Otology+and+Neurotology&rft.issn=15317129&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Cisplatin-induced vomiting depends on circadian timing. AN - 72356487; 11763992 AB - We examined whether the clock time of cisplatin plus antiemetic and diuretic administration affects the amount of cisplatin-associated emesis and severity of renal toxicity. We treated 22 patients with urogenital cancer with two courses of chemotherapy containing 70 mg/m2 of cisplatin. Cisplatin together with furosemide was administered in the morning (05:00) or evening (17:00) during two courses 1 month apart in a crossover fashion. Ondansetron was given either before or after cisplatin to control nausea and vomiting. The number of vomiting episodes, serum creatinine, serum urea nitrogen (BUN), creatinine clearance, and urinary beta-N-acetyl glucosamidase (NAG) concentration were evaluated before and after each treatment course. Regardless of the timing of ondansetron, morning compared to evening cisplatin was always associated with greater vomiting in the first treatment course. However, prophylactic administration of ondansetron markedly diminished the impact of the clock time of cisplatin administration. Serum creatinine transiently decreased rather than increased 14 days after cisplatin and furosemide administration, while NAG excretion increased 3 days after cisplatin and furosemide administration. In the first course, serum creatinine levels were similar regardless of the clock time of cisplatin and furosemide administration. However, in the second course, serum creatinine rose in patients given evening cisplatin and furosemide, while it remained unchanged in those given morning cisplatin and furosemide. Moreover, the first course morning cisplatin and furosemide treatment was associated with less change in NAG excretion (less kidney toxicity) than the first course of evening cisplatin and furosemide treatment. The second course evening cisplatin and furosemide treatment was associated with an increase in NAG excretion compared to the first course of treatment, while morning cisplatin and furosemide treatment in the second course showed less change in NAG excretion compared to the first course. The clock time of cisplatin administration had an impact on the frequency of emesis. Prophylactic ondansetron, however, diminished the time-of-day dependency of cisplatin-induced vomiting. Administration of cisplatin and furosemide in the morning rather than evening appears to cause less renal damage, and this damage may be further reduced with aggressive hydration and routine administration of furosemide. JF - Chronobiology international AU - Kobayashi, M AU - To, H AU - Tokue, A AU - Fujimura, A AU - Kobayashi, E AD - Department of Urology, Center of Molecular Medicine, Jichi Medical School, Tochigi, Japan. minoru.kobayashi@med.va.gov Y1 - 2001/09// PY - 2001 DA - September 2001 SP - 851 EP - 863 VL - 18 IS - 5 SN - 0742-0528, 0742-0528 KW - Antiemetics KW - 0 KW - Antineoplastic Agents KW - Diuretics KW - Ondansetron KW - 4AF302ESOS KW - Furosemide KW - 7LXU5N7ZO5 KW - Creatinine KW - AYI8EX34EU KW - Acetylglucosaminidase KW - EC 3.2.1.52 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Urogenital Neoplasms -- drug therapy KW - Ondansetron -- administration & dosage KW - Humans KW - Acetylglucosaminidase -- urine KW - Kidney -- drug effects KW - Aged KW - Blood Urea Nitrogen KW - Creatinine -- blood KW - Urogenital Neoplasms -- physiopathology KW - Antiemetics -- administration & dosage KW - Adult KW - Kidney -- injuries KW - Cross-Over Studies KW - Furosemide -- administration & dosage KW - Middle Aged KW - Diuretics -- administration & dosage KW - Male KW - Kidney -- physiopathology KW - Antineoplastic Agents -- administration & dosage KW - Vomiting -- chemically induced KW - Cisplatin -- adverse effects KW - Chronotherapy KW - Cisplatin -- administration & dosage KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72356487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chronobiology+international&rft.atitle=Cisplatin-induced+vomiting+depends+on+circadian+timing.&rft.au=Kobayashi%2C+M%3BTo%2C+H%3BTokue%2C+A%3BFujimura%2C+A%3BKobayashi%2C+E&rft.aulast=Kobayashi&rft.aufirst=M&rft.date=2001-09-01&rft.volume=18&rft.issue=5&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=Chronobiology+international&rft.issn=07420528&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-10 N1 - Date created - 2001-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The cost-effectiveness of buprenorphine maintenance therapy for opiate addiction in the United States. AN - 72217134; 11672491 AB - To determine the cost-effectiveness of buprenorphine maintenance therapy for opiate addiction in the United States, particularly its effect on the HIV epidemic. We developed a dynamic model to capture the effects of adding buprenorphine maintenance to the current opiate dependence treatment system. We evaluated incremental costs, including all health-care costs, and incremental effectiveness, measured as quality-adjusted life years (QALYs) of survival. We considered communities with HIV prevalence among injection drug users of 5% and 40%. Because no price has been set in the United States for a dose of buprenorphine, we considered three prices per dose: $5, $15, and $30. If buprenorphine increases the number of individuals in maintenance treatment by 10%, but does not affect the number of individuals receiving methadone maintenance, the cost-effectiveness ratios for buprenorphine maintenance therapy are less than $45 000 per QALY gained for all prices, in both the low-prevalence and high-prevalence communities. If the same number of individuals enter buprenorphine maintenance (10% of the number currently in methadone), but half are injection drug users newly entering maintenance and half are individuals who switched from methadone to buprenorphine, the cost-effectiveness ratios in both communities are less than $45 000 per QALY gained for the $5 and $15 prices, and greater than $65 000 per QALY gained for the $30 price. At a price of $5 or less per dose, buprenorphine maintenance is cost-effective under all scenarios we considered. At $15 per dose, it is cost-effective if its adoption does not lead to a net decline in methadone use, or if a medium to high value is assigned to the years of life lived by injection drug users and those in maintenance therapy. At $30 per dose, buprenorphine will be cost-effective only under the most optimistic modeling assumptions. JF - Addiction (Abingdon, England) AU - Barnett, P G AU - Zaric, G S AU - Brandeau, M L AD - Health Economics Resource Center, Veterans Affairs Palo Alto Health Care System, Menlo Park, CA, USA and the Department of Health Research and Policy, Stanford University, Stanford, CA, USA. paul.barnett@med.va.gov Y1 - 2001/09// PY - 2001 DA - September 2001 SP - 1267 EP - 1278 VL - 96 IS - 9 SN - 0965-2140, 0965-2140 KW - Narcotic Antagonists KW - 0 KW - Buprenorphine KW - 40D3SCR4GZ KW - Index Medicus KW - United States KW - Quality-Adjusted Life Years KW - Humans KW - Cost-Benefit Analysis KW - Buprenorphine -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Buprenorphine -- economics KW - Opioid-Related Disorders -- rehabilitation KW - Opioid-Related Disorders -- economics KW - Narcotic Antagonists -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72217134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=The+cost-effectiveness+of+buprenorphine+maintenance+therapy+for+opiate+addiction+in+the+United+States.&rft.au=Barnett%2C+P+G%3BZaric%2C+G+S%3BBrandeau%2C+M+L&rft.aulast=Barnett&rft.aufirst=P&rft.date=2001-09-01&rft.volume=96&rft.issue=9&rft.spage=1267&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-10-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Addiction. 2001 Oct;96(10):1515-7 [11599513] Addiction. 2001 Oct;96(10):1515 [11599512] Addiction. 2001 Oct;96(10):1517-8 [11599514] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Divalproex sodium in alcohol withdrawal: a randomized double-blind placebo-controlled clinical trial. AN - 71210364; 11584152 AB - Divalproex sodium, an anticonvulsant and antikindling agent and gamma-aminobutyric acid enhancer, has been proposed as an alternative to benzodiazepines for treating alcohol withdrawal. This study reports on a randomized, double-blind, placebo-controlled trial of divalproex sodium in acute alcohol withdrawal. Thirty-six hospitalized patients experiencing moderate alcohol withdrawal as measured by a score of at least 10 on the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar) were randomized to receive either divalproex sodium 500 mg three times per day for 7 days or matched placebo in a double-blind manner. All subjects received a baseline dose of oxazepam and had additional oxazepam available as a rescue medication in accordance with a standard, symptom-triggered detoxification protocol. Mean total milligrams of oxazepam received, progression of withdrawal symptoms, psychological distress as measured by the Symptom Checklist-90, side effects, and adverse outcomes were compared between groups. Use of divalproex sodium resulted in less use of oxazepam (p or=10) after 12 hr. The progression in severity of withdrawal symptoms (increase in CIWA-Ar above baseline) was also significantly greater in the placebo group (p < 0.05). This placebo-controlled pilot study suggests that divalproex sodium significantly affects the course of acute alcohol withdrawal and reduces the need for treatment with a benzodiazepine. A more aggressive loading dose strategy may demonstrate a more robust or earlier response. JF - Alcoholism, clinical and experimental research AU - Reoux, J P AU - Saxon, A J AU - Malte, C A AU - Baer, J S AU - Sloan, K L AD - Veterans Affairs Puget Sound Health Care System and Department of Psychiatry, University of Washington School of Medicine, Seattle, Washington 98108, USA. joe.reoux@med.va.gov Y1 - 2001/09// PY - 2001 DA - September 2001 SP - 1324 EP - 1329 VL - 25 IS - 9 SN - 0145-6008, 0145-6008 KW - Anticonvulsants KW - 0 KW - GABA Modulators KW - Placebos KW - Ethanol KW - 3K9958V90M KW - Valproic Acid KW - 614OI1Z5WI KW - Oxazepam KW - 6GOW6DWN2A KW - Index Medicus KW - GABA Modulators -- therapeutic use KW - Oxazepam -- therapeutic use KW - Depression KW - Anxiety KW - Double-Blind Method KW - Alcoholism -- therapy KW - Humans KW - Aged KW - Oxazepam -- administration & dosage KW - Hostility KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Adolescent KW - GABA Modulators -- administration & dosage KW - Male KW - Female KW - Ethanol -- adverse effects KW - Anticonvulsants -- adverse effects KW - Substance Withdrawal Syndrome -- drug therapy KW - Valproic Acid -- adverse effects KW - Anticonvulsants -- administration & dosage KW - Valproic Acid -- therapeutic use KW - Anticonvulsants -- therapeutic use KW - Valproic Acid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71210364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Divalproex+sodium+in+alcohol+withdrawal%3A+a+randomized+double-blind+placebo-controlled+clinical+trial.&rft.au=Reoux%2C+J+P%3BSaxon%2C+A+J%3BMalte%2C+C+A%3BBaer%2C+J+S%3BSloan%2C+K+L&rft.aulast=Reoux&rft.aufirst=J&rft.date=2001-09-01&rft.volume=25&rft.issue=9&rft.spage=1324&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - GDNF improves cerebellar Purkinje neuron function in aged F344 rats. AN - 71114435; 11514987 AB - Aging is associated with a decline in the function of beta-adrenergic receptor responses in the cerebellum. This decline in noradrenergic receptor sensitivity may underlie some of the accompanying age-related declines in motoric learning behaviors. Glial cell line-derived neurotrophic factor (GDNF) has been reported to prevent the degeneration of noradrenergic neurons following neurotoxic lesions. Thus, it was of interest to examine if GDNF would have a beneficial effect on age-related declines in noradrenergic function. Eighteen-month-old F344 rats were injected with 500 microg GDNF in 20 microl into the cisterna magna. Three weeks following GDNF or vehicle treatment, rats were tested on a motor coordination task and then examined electrophysiologically under urethane anesthesia. GDNF did not produce an improvement in performance on an inclined balance beam or an accelerating rotorod. In young (3-month-old) F344 rats isoproterenol (ISO) will increase GABAergic inhibitions in the majority of cells examined; however, in aged rats only about 30% of neurons demonstrate this phenotype. In the aged rats treated with GDNF, ISO was able to increase GABAergic inhibitions in greater than 75% of the neurons tested, thus returning the neurons to a young phenotype. We examined the brains for expression of bcl-2, which has been shown to be increased in the aged cerebellum. GDNF was able to down-regulate this neuronal signal. Thus, intra-cisterna magna delivery of GDNF to aged rats improved beta-adrenergic receptor function and reduced stress related signaling of bcl-2 in the aged F344 rats to a level similar to that observed in young rats. Copyright 2001 Wiley-Liss, Inc. JF - Microscopy research and technique AU - Bickford, P C AU - Bowenkamp, K AU - Taglialatela, G AU - Hoertig, G AU - Granholm, A C AD - Veterans Administration Medical Center, Tampa, Florida 33612, USA. pbickfor@hsc.usf.edu Y1 - 2001/09/01/ PY - 2001 DA - 2001 Sep 01 SP - 309 EP - 316 VL - 54 IS - 5 SN - 1059-910X, 1059-910X KW - Gdnf protein, rat KW - 0 KW - Glial Cell Line-Derived Neurotrophic Factor KW - Nerve Growth Factors KW - Nerve Tissue Proteins KW - Neuroprotective Agents KW - Proto-Oncogene Proteins c-bcl-2 KW - Index Medicus KW - Rats KW - Behavior, Animal -- drug effects KW - Animals KW - Rats, Inbred F344 KW - Proto-Oncogene Proteins c-bcl-2 -- analysis KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Immunohistochemistry KW - Injections, Intraventricular KW - Cerebellum -- cytology KW - Purkinje Cells -- drug effects KW - Neuroprotective Agents -- administration & dosage KW - Cerebellum -- drug effects KW - Aging -- drug effects KW - Purkinje Cells -- metabolism KW - Nerve Tissue Proteins -- administration & dosage KW - Nerve Tissue Proteins -- pharmacology KW - Cerebellum -- physiology KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71114435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microscopy+research+and+technique&rft.atitle=GDNF+improves+cerebellar+Purkinje+neuron+function+in+aged+F344+rats.&rft.au=Bickford%2C+P+C%3BBowenkamp%2C+K%3BTaglialatela%2C+G%3BHoertig%2C+G%3BGranholm%2C+A+C&rft.aulast=Bickford&rft.aufirst=P&rft.date=2001-09-01&rft.volume=54&rft.issue=5&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Microscopy+research+and+technique&rft.issn=1059910X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-11-01 N1 - Date created - 2001-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Invasion of Human Fallopian Tube Epithelium by Escherichia coli Expressing Combinations of a Gonococcal Porin, Opacity-Associated Protein, and Chimeric Lipo-oligosaccharide AN - 18091706; 5185134 AB - The transepithelial migration of Escherichia coli that expressed all possible combinations of a plasmid-encoded gonococcal porin (Por), opacity-associated protein (Opa), and 3F11 lipo-oligosaccharide (LOS) epitope was investigated. Surface expression of Por mediated selective changes in E. coli antibiotic susceptibility, and coexpression of Opa and the 3F11 LOS epitope mediated bacterial clumping (P < .01). In the human fallopian tube organ-culture model, Opa-producing variants attached up to 44-fold better than control bacteria (P < .01), and Por-producing variants exceeded submucosal invasion of control bacteria by 500-fold (P < .01). Opa and Por each facilitated intracellular invasion 20-40-fold (P < .01). In dual expresser variants, the 3F11 LOS epitope markedly reduced attachment and invasion mediated by Opa or Por. The LOS inhibitory effect was curbed when all 3 factors were expressed, which suggests an additional interaction of the 3 factors at the bacterial surface. Por, Opa, and LOS play important roles in Neisseria gonorrhoeae trafficking across human fallopian tube epithelium. JF - Journal of Infectious Diseases AU - Gorby, G L AU - Ehrhardt, A F AU - Apicella, MA AU - Elkins, C AD - Department of Medicine, Omaha Veterans Administration Medical Center, Creighton University School of Medicine, Omaha, Nebraska, USA Y1 - 2001/08/15/ PY - 2001 DA - 2001 Aug 15 SP - 460 EP - 472 VL - 184 IS - 4 SN - 0022-1899, 0022-1899 KW - man KW - invasion KW - lipooligosaccharides KW - opacity-associated protein KW - Microbiology Abstracts B: Bacteriology KW - Porins KW - Escherichia coli KW - Epithelium KW - Reproductive organs KW - Fallopian tube KW - Neisseria gonorrhoeae KW - J 02847:Genitourinary tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18091706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Invasion+of+Human+Fallopian+Tube+Epithelium+by+Escherichia+coli+Expressing+Combinations+of+a+Gonococcal+Porin%2C+Opacity-Associated+Protein%2C+and+Chimeric+Lipo-oligosaccharide&rft.au=Gorby%2C+G+L%3BEhrhardt%2C+A+F%3BApicella%2C+MA%3BElkins%2C+C&rft.aulast=Gorby&rft.aufirst=G&rft.date=2001-08-15&rft.volume=184&rft.issue=4&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Neisseria gonorrhoeae; Escherichia coli; Reproductive organs; Fallopian tube; Epithelium; Porins ER - TY - JOUR T1 - GM-CSF increases AP-1 DNA binding and Ref-1 amounts in human alveolar macrophages. AN - 71097815; 11509337 AB - Alveolar macrophages have been implicated in the pathogenesis of a number of acute and chronic lung disorders. A characteristic feature of many of the chronic lung diseases is that the types of macrophages in the lung change, and in most instances, the cells resemble monocyte-like cells. We have previously shown that normal human alveolar macrophages have a decreased capacity to express protein kinase C (PKC)-induced DNA binding activity of the transcription factor activator protein (AP)-1 compared with monocytes. This decrease in AP-1 DNA binding appears to be due to a defect in redox regulation of AP-1 proteins via a decrease in the redox active protein Ref-1. The hypothesis for this study is that there are factors generated during the development of chronic lung disease that increase AP-1 DNA binding activity and Ref-1 production in human alveolar macrophages. We have focused specifically on granulocyte-macrophage colony-stimulating factor (GM-CSF) as a prototype mediator that can be released by alveolar macrophages and is related to the fibrotic process in the lung. We found that after a 24-h incubation with GM-CSF, AP-1 DNA binding was significantly increased in both unstimulated, interleukin (IL)-13, and phorbol myristate acetate (PMA)-stimulated alveolar macrophages and that there was a corresponding increase in Ref-1 protein by Western blot analysis in the PMA-stimulated group. This suggests that disease-related cytokines such as GM-CSF and IL-13 may modulate AP-1 DNA binding activity in alveolar macrophages. JF - American journal of respiratory cell and molecular biology AU - Flaherty, D M AU - Monick, M M AU - Carter, A B AU - Peterson, M W AU - Hunninghake, G W AD - Department of Internal Medicine, University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA. flahertydm@mail.medicine.uiowa.edu Y1 - 2001/08// PY - 2001 DA - August 2001 SP - 254 EP - 259 VL - 25 IS - 2 SN - 1044-1549, 1044-1549 KW - Interleukin-13 KW - 0 KW - Proto-Oncogene Proteins c-fos KW - Proto-Oncogene Proteins c-jun KW - Transcription Factor AP-1 KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - DNA KW - 9007-49-2 KW - Carbon-Oxygen Lyases KW - EC 4.2.- KW - APEX1 protein, human KW - EC 4.2.99.18 KW - DNA-(Apurinic or Apyrimidinic Site) Lyase KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Oxidation-Reduction KW - Interleukin-13 -- administration & dosage KW - Base Sequence KW - Proto-Oncogene Proteins c-fos -- metabolism KW - Humans KW - In Vitro Techniques KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Proto-Oncogene Proteins c-jun -- metabolism KW - Interleukin-13 -- pharmacology KW - Macrophages, Alveolar -- metabolism KW - Granulocyte-Macrophage Colony-Stimulating Factor -- administration & dosage KW - Carbon-Oxygen Lyases -- metabolism KW - Transcription Factor AP-1 -- metabolism KW - DNA -- metabolism KW - DNA -- genetics KW - Macrophages, Alveolar -- drug effects KW - Granulocyte-Macrophage Colony-Stimulating Factor -- pharmacology KW - Transcription Factor AP-1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71097815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=GM-CSF+increases+AP-1+DNA+binding+and+Ref-1+amounts+in+human+alveolar+macrophages.&rft.au=Flaherty%2C+D+M%3BMonick%2C+M+M%3BCarter%2C+A+B%3BPeterson%2C+M+W%3BHunninghake%2C+G+W&rft.aulast=Flaherty&rft.aufirst=D&rft.date=2001-08-01&rft.volume=25&rft.issue=2&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-11 N1 - Date created - 2001-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A neurobiological basis for substance abuse comorbidity in schizophrenia. AN - 71132078; 11526998 AB - It is commonly held that substance use comorbidity in schizophrenia represents self-medication, an attempt by patients to alleviate adverse positive and negative symptoms, cognitive impairment, or medication side effects. However, recent advances suggest that increased vulnerability to addictive behavior may reflect the impact of the neuropathology of schizophrenia on the neural circuitry mediating drug reward and reinforcement. We hypothesize that abnormalities in the hippocampal formation and frontal cortex facilitate the positive reinforcing effects of drug reward and reduce inhibitory control over drug-seeking behavior. In this model, disturbances in drug reward are mediated, in part, by dysregulated neural integration of dopamine and glutamate signaling in the nucleus accumbens resulting form frontal cortical and hippocampal dysfunction. Altered integration of these signals would produce neural and motivational changes similar to long-term substance abuse but without the necessity of prior drug exposure. Thus, schizophrenic patients may have a predilection for addictive behavior as a primary disease symptom in parallel to, and in many, cases independent from, their other symptoms. JF - Biological psychiatry AU - Chambers, R A AU - Krystal, J H AU - Self, D W AD - Ribicoff Research Facilities, West Haven Veterans Administration Hospital, Connecticut, USA. Y1 - 2001/07/15/ PY - 2001 DA - 2001 Jul 15 SP - 71 EP - 83 VL - 50 IS - 2 SN - 0006-3223, 0006-3223 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Frontal Lobe -- pathology KW - Disease Susceptibility KW - Neurobiology KW - Humans KW - Hippocampus -- metabolism KW - Frontal Lobe -- metabolism KW - Nucleus Accumbens -- metabolism KW - Dopamine -- metabolism KW - Nucleus Accumbens -- pathology KW - Hippocampus -- pathology KW - Schizophrenia -- metabolism KW - Schizophrenic Psychology KW - Substance-Related Disorders -- complications KW - Schizophrenia -- pathology KW - Schizophrenia -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71132078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=A+neurobiological+basis+for+substance+abuse+comorbidity+in+schizophrenia.&rft.au=Chambers%2C+R+A%3BKrystal%2C+J+H%3BSelf%2C+D+W&rft.aulast=Chambers&rft.aufirst=R&rft.date=2001-07-15&rft.volume=50&rft.issue=2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-10 N1 - Date created - 2001-08-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2000 Oct 1;20(19):7489-95 [11007908] Am J Psychiatry. 2001 Mar;158(3):497-8 [11229999] Med Aspects Hum Sex. 1976 Apr;10(4):32, 35, 39, passim [957810] Psychol Med. 1977 May;7(2):213-21 [560024] Pharmacol Biochem Behav. 1982 Aug;17(2):193-202 [7134232] Neuroscience. 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2017-01-18 ER - TY - JOUR T1 - Neuroprotective effects of extracellular glutamate are absent in hippocampal organotypic cultures treated with the amyloid peptide Abeta(25-35). AN - 70975819; 11430902 AB - Hippocampal cells are particularly vulnerable in Alzheimer's disease but the cause of cell death is unknown. Amyloid toxicity has been implicated in hippocampal cell death, but its specific mechanisms are poorly understood. We used confocal microscopy to examine the effects of the amyloid peptide fragment 25-35 (Abeta(25-35)) on cell death in organotypic hippocampal slice cultures. Addition of glutamate to the culture medium significantly improved nerve cell survival in cultures subjected to consecutive medium exchanges. This effect was lost if cultures were treated with the amyloid peptide fragment Abeta(25-35) but not the inactive peptide 35-25. These data suggest that one of the mechanisms responsible for amyloid toxicity may be inhibition of the survival promoting effects of extracellular glutamate. JF - Brain research AU - Baskys, A AU - Adamchik, Y AD - Department of Physiology, University of Toronto, Toronto, Ontario, M5T 2S8, Canada. andrius.baskys@med.va.gov Y1 - 2001/07/13/ PY - 2001 DA - 2001 Jul 13 SP - 188 EP - 194 VL - 907 IS - 1-2 SN - 0006-8993, 0006-8993 KW - 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one KW - 0 KW - Amyloid beta-Peptides KW - Androstadienes KW - Culture Media, Serum-Free KW - Enzyme Inhibitors KW - Flavonoids KW - Fluorescent Dyes KW - Neuroprotective Agents KW - Peptide Fragments KW - Receptors, Glutamate KW - amyloid beta-protein (25-35) KW - amyloid beta-protein (35-25) KW - Propidium KW - 36015-30-2 KW - Glutamic Acid KW - 3KX376GY7L KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - wortmannin KW - XVA4O219QW KW - Index Medicus KW - Microscopy, Confocal KW - Fluorescent Dyes -- analysis KW - MAP Kinase Signaling System -- drug effects KW - Animals KW - Extracellular Space KW - Receptors, Glutamate -- drug effects KW - Androstadienes -- pharmacology KW - Cell Death -- drug effects KW - Rats KW - Dentate Gyrus -- drug effects KW - Dentate Gyrus -- pathology KW - Propidium -- analysis KW - Rats, Wistar KW - Enzyme Inhibitors -- pharmacology KW - Alzheimer Disease -- metabolism KW - Culture Media, Serum-Free -- pharmacology KW - Flavonoids -- pharmacology KW - Organ Culture Techniques KW - Phosphatidylinositol 3-Kinases -- antagonists & inhibitors KW - Alzheimer Disease -- pathology KW - Peptide Fragments -- toxicity KW - Amyloid beta-Peptides -- toxicity KW - Peptide Fragments -- pharmacology KW - Amyloid beta-Peptides -- pharmacology KW - Hippocampus -- pathology KW - Glutamic Acid -- pharmacology KW - Neuroprotective Agents -- pharmacology KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70975819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Neuroprotective+effects+of+extracellular+glutamate+are+absent+in+hippocampal+organotypic+cultures+treated+with+the+amyloid+peptide+Abeta%2825-35%29.&rft.au=Baskys%2C+A%3BAdamchik%2C+Y&rft.aulast=Baskys&rft.aufirst=A&rft.date=2001-07-13&rft.volume=907&rft.issue=1-2&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-04 N1 - Date created - 2001-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tumor chronobiology AN - 17903617; 5175195 AB - Traditionally, drug delivery has meant getting a simple chemical absorbed predictably from the gut or from the site of injection. A second-generation drug delivery goal has been the perfection of continuous constant rate (zero-order) delivery of simple xenobiotic molecules or common hormones. Living organisms are not 'zero-order' in their requirement for or response to drugs. They are predictable resonating dynamic systems, which require different amounts of drug at predictably different times within the circadian cycle in order to maximize desired and minimize undesired drug effects. JF - Journal of Controlled Release AU - Hrushesky, WJM AD - WJB Dorn VA Medical Center, and the School of Medicine and Norman J. Arnold School of Public Health of the University of South Carolina, Columbia, SC 29209, USA, william.hrushesky@med.va.gov Y1 - 2001/07/06/ PY - 2001 DA - 2001 Jul 06 SP - 27 EP - 30 VL - 74 IS - 1-3 SN - 0168-3659, 0168-3659 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Drug delivery KW - Chronobiology KW - Xenobiotics KW - Tumors KW - Hormones KW - Controlled release KW - W3 33388:Drug delivery vehicles (liposomes, cochleates, microspheres) KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17903617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Controlled+Release&rft.atitle=Tumor+chronobiology&rft.au=Hrushesky%2C+WJM&rft.aulast=Hrushesky&rft.aufirst=WJM&rft.date=2001-07-06&rft.volume=74&rft.issue=1-3&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Journal+of+Controlled+Release&rft.issn=01683659&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Tumors; Chronobiology; Controlled release; Hormones; Xenobiotics; Drug delivery ER - TY - JOUR T1 - Multivariate Prediction of Posttraumatic Symptoms in Psychiatric Inpatients AN - 954613656; 14263051 AB - Based on a conceptual framework for the long-term effects of childhood abuse, this study examined the capacity of childhood family environment (caretaker dysfunction, neglect, perceived social support), violent abuse (physical and sexual), and individual variables (other abuse) to predict adult psychiatric symptoms of PTSD, dissociation, and depression. Complete interview data were obtained from 178 psychiatric inpatients who varied greatly on abuse status and severity. Results of multiple regressions of predictor variables onto the three outcome variables showed that the predictor variables accounted for 15% (for depression) to 42% (for PTSD) of the variance in these symptoms and that violent abuse uniquely accounted for a significant proportion of the variance in outcomes for all three of the symptom groups studied. JF - Journal of Traumatic Stress AU - Carlson, Eve B AU - Dalenberg, Constance AU - Armstrong, Judith AU - Daniels, Jill Walker AU - Loewenstein, Richard AU - Roth, David AD - Department of Veterans Affairs, National Center for PTSD, Palo Alto Health Care System, Menlo Park, California, eve.carlson@med.va.gov Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 549 EP - 567 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 14 IS - 3 SN - 0894-9867, 0894-9867 KW - Health & Safety Science Abstracts KW - posttraumatic stress disorder KW - child abuse KW - Stress KW - Children KW - depression KW - Perception KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954613656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Traumatic+Stress&rft.atitle=Multivariate+Prediction+of+Posttraumatic+Symptoms+in+Psychiatric+Inpatients&rft.au=Carlson%2C+Eve+B%3BDalenberg%2C+Constance%3BArmstrong%2C+Judith%3BDaniels%2C+Jill+Walker%3BLoewenstein%2C+Richard%3BRoth%2C+David&rft.aulast=Carlson&rft.aufirst=Eve&rft.date=2001-07-01&rft.volume=14&rft.issue=3&rft.spage=549&rft.isbn=&rft.btitle=&rft.title=Journal+of+Traumatic+Stress&rft.issn=08949867&rft_id=info:doi/10.1023%2FA%3A1011164707774 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - posttraumatic stress disorder; Perception; child abuse; Stress; Children; depression DO - http://dx.doi.org/10.1023/A:1011164707774 ER - TY - JOUR T1 - Patterns of verbal learning and memory in traumatic brain injury. AN - 85364272; pmid-11459109 AB - CVLT and WMS-R Digit Span variables were used to calculate indexes of seven specific short- and long-term memory processes: working memory span and central executive functions, and long-term memory encoding, consolidation, retention, retrieval, control abilities. Scores on these indexes were then cluster-analyzed to determine whether subtypes of memory performance exist that correspond to deficits in these theoretical memory constructs. Parallel analyses were conducted with two large samples (N = 150 and N = 151) of individuals who had sustained a traumatic brain injury (TBI). Findings showed that TBI results in subgroups of memory disorders with specific deficits in consolidation, retention, and retrieval processes. Control problems (keeping track of list versus non-list items) only appeared in conjunction with retrieval deficits. Working memory span and central executive functioning (i.e., the ability to manipulate information in working memory) do not appear to be deficits characteristic of TBI as no such clusters emerged in the analyses. By using specific indexes of memory processes, and in contrast to previous studies, patterns of memory dysfunction were found that correspond to deficits in theoretically meaningful memory constructs. JF - Journal of the International Neuropsychological Society : JINS AU - Curtiss, G AU - Vanderploeg, R D AU - Spencer, J AU - Salazar, A M AD - Defense and Veterans Head Injury Program, Walter Reed Army Medical Center, Washington, DC, USA. Glenn.Curtiss@med.va.gov Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 574 EP - 585 VL - 7 IS - 5 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Amnesia: diagnosis KW - Amnesia: psychology KW - *Brain Concussion: diagnosis KW - Brain Concussion: psychology KW - *Brain Damage, Chronic: diagnosis KW - Brain Damage, Chronic: psychology KW - *Brain Injury, Chronic: diagnosis KW - Brain Injury, Chronic: psychology KW - Female KW - Humans KW - Male KW - Middle Aged KW - *Neuropsychological Tests KW - Retention (Psychology) KW - Serial Learning KW - Verbal Learning KW - Wechsler Scales UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85364272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Patterns+of+verbal+learning+and+memory+in+traumatic+brain+injury.&rft.au=Curtiss%2C+G%3BVanderploeg%2C+R+D%3BSpencer%2C+J%3BSalazar%2C+A+M&rft.aulast=Curtiss&rft.aufirst=G&rft.date=2001-07-01&rft.volume=7&rft.issue=5&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Differential episodic and semantic memory performance in Alzheimer's disease and vascular dementias. AN - 85361051; pmid-11459108 AB - Differential performance on measures of episodic and semantic memory were examined in AD, cortical vascular dementia (CVaD), subcortica] vascular dementia (SVaD), and controls. Groups were matched on age, education, and gender; dementia groups also were matched on severity. Recognition/retrieval differences were found only between SVaD and AD groups, not between CVaD and AD. Thus, recognition/retrieval differences are likely secondary to subcortical pathology rather than to vascular etiology per se. Similarly, significant numbers of memory errors were associated with cortical pathology, regardless of etiology. Error rate differences were found only between SVaD and AD groups, not between CVaD and AD. Finally, rapid forgetting was unique to AD; however, since no difference was found between SVaD and AD, rapid forgetting may occur only as AD progresses. No semantic memory measure differentiated AD from either CVaD or SVaD subjects. Results suggest that some previously reported episodic differences may be due to cortical versus white matter subcortical pathology, rather than to AD versus vascular etiology. JF - Journal of the International Neuropsychological Society : JINS AU - Vanderploe, R D AU - Yuspeh, R L AU - Schinka, J A AD - James A. Haley VA Medical Center, Tampa, Florida 33612, USA. Rodney.Vanderploeg@med.va.gov Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 563 EP - 573 VL - 7 IS - 5 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - *Alzheimer Disease: diagnosis KW - Alzheimer Disease: psychology KW - *Dementia, Vascular: diagnosis KW - Dementia, Vascular: psychology KW - Diagnosis, Differential KW - Disease Progression KW - Female KW - Humans KW - Male KW - *Mental Recall KW - *Neuropsychological Tests: statistics & numerical data KW - Psychometrics KW - Reproducibility of Results KW - *Verbal Learning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85361051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Differential+episodic+and+semantic+memory+performance+in+Alzheimer%27s+disease+and+vascular+dementias.&rft.au=Vanderploe%2C+R+D%3BYuspeh%2C+R+L%3BSchinka%2C+J+A&rft.aulast=Vanderploe&rft.aufirst=R&rft.date=2001-07-01&rft.volume=7&rft.issue=5&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Seminal figures in the History of Movement Disorders: Hammond, Osler, and Huntington. Part 11 of the MDS-Sponsored History of Movement Disorders Exhibit, Barcelona, June 2000. AN - 85352734; pmid-11481703 JF - Movement disorders : official journal of the Movement Disorder Society AU - Lanska, D J AU - Goetz, C G AU - Chmura, T A AD - Veterans Affairs Medical Center, Great Lakes VA Healthcare System, Tomah, Wisconsin, USA. douglas.lanska@med.va.gov Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 749 EP - 753 VL - 16 IS - 4 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Canada KW - Exhibits as Topic KW - History, 19th Century KW - History, 20th Century KW - Humans KW - *Movement Disorders: history KW - Spain KW - United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85352734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Seminal+figures+in+the+History+of+Movement+Disorders%3A+Hammond%2C+Osler%2C+and+Huntington.+Part+11+of+the+MDS-Sponsored+History+of+Movement+Disorders+Exhibit%2C+Barcelona%2C+June+2000.&rft.au=Lanska%2C+D+J%3BGoetz%2C+C+G%3BChmura%2C+T+A&rft.aulast=Lanska&rft.aufirst=D&rft.date=2001-07-01&rft.volume=16&rft.issue=4&rft.spage=749&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Development of instruments for abnormal movements: dynamometers, the dynamograph, and tremor recorders. Part 9 of the MDS-Sponsored History of Movement Disorders Exhibit, Barcelona, June 2000. AN - 85352527; pmid-11481701 JF - Movement disorders : official journal of the Movement Disorder Society AU - Lanska, D J AU - Goetz, C G AU - Chmura, T A AD - Veterans Affairs Medical Center, Great Lakes VA Healthcare System, Tomah, Wisconsin, USA. douglas.lanska@med.va.gov Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 736 EP - 741 VL - 16 IS - 4 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - *Electrodiagnosis: history KW - Electrodiagnosis: instrumentation KW - Exhibits as Topic KW - History, 19th Century KW - History, 20th Century KW - Humans KW - Movement Disorders: diagnosis KW - *Movement Disorders: history KW - *Myography: history KW - Myography: instrumentation KW - *Neurologic Examination: history KW - Spain KW - Tremor: diagnosis KW - *Tremor: history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85352527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Development+of+instruments+for+abnormal+movements%3A+dynamometers%2C+the+dynamograph%2C+and+tremor+recorders.+Part+9+of+the+MDS-Sponsored+History+of+Movement+Disorders+Exhibit%2C+Barcelona%2C+June+2000.&rft.au=Lanska%2C+D+J%3BGoetz%2C+C+G%3BChmura%2C+T+A&rft.aulast=Lanska&rft.aufirst=D&rft.date=2001-07-01&rft.volume=16&rft.issue=4&rft.spage=736&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Development of instruments for abnormal movements: postural sway and gait analyses. Part 10 of the MDS-Sponsored History of Movement Disorders Exhibit, Barcelona, June 2000. AN - 85350068; pmid-11481702 JF - Movement disorders : official journal of the Movement Disorder Society AU - Lanska, D J AU - Goetz, C G AU - Chmura, T A AD - Veterans Affairs Medical Center, Great Lakes VA Healthcare System, Tomah, Wisconsin, USA. douglas.lanska@med.va.gov Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 742 EP - 748 VL - 16 IS - 4 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Exhibits as Topic KW - *Gait Apraxia: history KW - History, 19th Century KW - History, 20th Century KW - Humans KW - Movement Disorders: diagnosis KW - *Movement Disorders: history KW - *Neurologic Examination: history KW - Neurologic Examination: instrumentation KW - *Postural Balance KW - *Posture KW - Spain UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85350068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Development+of+instruments+for+abnormal+movements%3A+postural+sway+and+gait+analyses.+Part+10+of+the+MDS-Sponsored+History+of+Movement+Disorders+Exhibit%2C+Barcelona%2C+June+2000.&rft.au=Lanska%2C+D+J%3BGoetz%2C+C+G%3BChmura%2C+T+A&rft.aulast=Lanska&rft.aufirst=D&rft.date=2001-07-01&rft.volume=16&rft.issue=4&rft.spage=742&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Prognosis for papillary serous carcinoma of the endometrium after surgical staging. AN - 71121013; 11520370 AB - To investigate the pattern of failure and the prognosis following pathological staging for uterine papillary serous carcinoma (UPSC). A retrospective review was conducted of 22 patients with UPSC, treated between 1989 and 1998 at a single institution. All patients were surgically staged. Two patients with advanced disease received chemotherapy only. Two patients with early-stage disease were followed without further treatment. Eighteen patients received postoperative irradiation; eight patients received whole abdominal irradiation (WART), and the remaining 10 patients, pelvic irradiation (PRT). In addition, seven of these patients received vaginal cuff irradiation with low-dose-rate or high-dose-rate brachytherapy. Toxicity, pattern of failure, and survival were evaluated and compared to the literature. Seven patients (32%) developed distant metastases, three out of seven (42%) after WART. Four out of seven patients who had distant metastases died from disease progression during subsequent chemotherapy. All patients with distant metastases had locally advanced-stage disease at presentation (six stage III, one stage IV). Four patients with pelvic recurrences developed concurrent (2) and subsequent (2) distant metastases. Three patients had isolated distant metastases. No patient with early stage-disease (stage I and II) died from disease progression. Pathological staging should be performed for all patients with UPSC to determine the prognosis as well as to tailor the treatment. The role of abdominal irradiation in the treatment of UPSC is yet to be determined; however, such an approach may not be necessary for the control of disease for patients with early-stage (I and II) disease. Patients with locally advanced-stage (stage III) disease are at risk of local regional failures and distant metastases despite WART. Therefore, the benefit of WART for advanced-stage disease is also questionable. Paclitaxel-based chemotherapy is currently being investigated in this setting. JF - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society AU - Nguyen, N P AU - Sallah, S AU - Karlsson, U AU - Vos, P AU - Ludin, A AU - Semer, D AU - Tait, D AU - Salehpour, M AU - Jendrasiak, G AU - Robiou, C AD - Department of Radiation Oncology, Southwestern University, Dallas, Texas 75216, USA. NamPhong.Nguyen@med.va.gov PY - 2001 SP - 305 EP - 311 VL - 11 IS - 4 SN - 1048-891X, 1048-891X KW - Index Medicus KW - Neoplasm Staging KW - Aged, 80 and over KW - Humans KW - North Carolina KW - Treatment Outcome KW - Retrospective Studies KW - Prognosis KW - Aged KW - Middle Aged KW - Female KW - Survival Analysis KW - Endometrial Neoplasms -- radiotherapy KW - Endometrial Neoplasms -- pathology KW - Carcinoma, Papillary -- surgery KW - Carcinoma, Papillary -- pathology KW - Carcinoma, Papillary -- radiotherapy KW - Carcinoma, Papillary -- mortality KW - Endometrial Neoplasms -- mortality KW - Endometrial Neoplasms -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71121013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+gynecological+cancer+%3A+official+journal+of+the+International+Gynecological+Cancer+Society&rft.atitle=Prognosis+for+papillary+serous+carcinoma+of+the+endometrium+after+surgical+staging.&rft.au=Nguyen%2C+N+P%3BSallah%2C+S%3BKarlsson%2C+U%3BVos%2C+P%3BLudin%2C+A%3BSemer%2C+D%3BTait%2C+D%3BSalehpour%2C+M%3BJendrasiak%2C+G%3BRobiou%2C+C&rft.aulast=Nguyen&rft.aufirst=N&rft.date=2001-07-01&rft.volume=11&rft.issue=4&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=International+journal+of+gynecological+cancer+%3A+official+journal+of+the+International+Gynecological+Cancer+Society&rft.issn=1048891X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-04 N1 - Date created - 2001-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of quetiapine in delirium: case reports. AN - 71076614; 11496025 JF - Psychosomatics AU - Torres, R AU - Mittal, D AU - Kennedy, R AD - University of Mississippi School of Medicine, Jackson, USA. rafael.torres@med.va.gov PY - 2001 SP - 347 EP - 349 VL - 42 IS - 4 SN - 0033-3182, 0033-3182 KW - Dibenzothiazepines KW - 0 KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Treatment Outcome KW - Referral and Consultation KW - Middle Aged KW - Male KW - Postoperative Complications -- drug therapy KW - Delirium -- etiology KW - Dibenzothiazepines -- adverse effects KW - Patient Care Team KW - Postoperative Complications -- etiology KW - Dibenzothiazepines -- therapeutic use KW - Delirium -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71076614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatics&rft.atitle=Use+of+quetiapine+in+delirium%3A+case+reports.&rft.au=Torres%2C+R%3BMittal%2C+D%3BKennedy%2C+R&rft.aulast=Torres&rft.aufirst=R&rft.date=2001-07-01&rft.volume=42&rft.issue=4&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Psychosomatics&rft.issn=00333182&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-04 N1 - Date created - 2001-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Failure of tolterodine to treat clozapine-induced nocturnal enuresis. AN - 71060040; 11485135 AB - To report the use and subsequent failure of the bladder-selective agent tolterodine, to treat clozapine-induced nocturnal enuresis in an adolescent patient with psychotic illness. A 16-year-old Hispanic girl was admitted to the state psychiatric hospital with a diagnosis of bipolar disorder with psychotic features. Clozapine therapy was initiated, and after three months of treatment the patient began experiencing episodes of nocturnal enuresis. The bladder-selective agent tolterodine was tried and subsequently failed to resolve the enuresis episodes. Desmopressin was initiated, which resulted in amelioration of symptoms. This is the first published report of using tolterodine to treat clozapine-induced nocturnal enuresis. Several methods to decrease clozapine-induced urinary incontinence have been used and typically include the addition of agents with high anticholinergic properties. Tolterodine is a bladder-selective anticholinergic agent indicated for the treatment of urinary urge incontinence and may be employed as a treatment for antipsychotic-induced incontinence. Nocturnal enuresis is an adverse effect that infrequently occurs with use of clozapine therapy. Although tolterodine was ineffective in our patient to treat clozapine-induced nocturnal enuresis, further trials are required to appropriately evaluate the effectiveness of tolterodine to treat this adverse drug reaction. JF - The Annals of pharmacotherapy AU - English, B A AU - Still, D J AU - Harper, J AU - Saklad, S R AD - Veterans Affairs Medical Center, Tuscaloosa, AL, USA. brett.english@med.va.gov PY - 2001 SP - 867 EP - 869 VL - 35 IS - 7-8 SN - 1060-0280, 1060-0280 KW - Antipsychotic Agents KW - 0 KW - Benzhydryl Compounds KW - Cresols KW - Muscarinic Antagonists KW - Phenylpropanolamine KW - 33RU150WUN KW - Tolterodine Tartrate KW - 5T619TQR3R KW - Clozapine KW - J60AR2IKIC KW - Index Medicus KW - Treatment Failure KW - Humans KW - Adolescent KW - Female KW - Psychotic Disorders -- drug therapy KW - Muscarinic Antagonists -- therapeutic use KW - Benzhydryl Compounds -- therapeutic use KW - Enuresis -- chemically induced KW - Clozapine -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Enuresis -- drug therapy KW - Cresols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71060040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Failure+of+tolterodine+to+treat+clozapine-induced+nocturnal+enuresis.&rft.au=English%2C+B+A%3BStill%2C+D+J%3BHarper%2C+J%3BSaklad%2C+S+R&rft.aulast=English&rft.aufirst=B&rft.date=2001-07-01&rft.volume=35&rft.issue=7-8&rft.spage=867&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-11 N1 - Date created - 2001-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Organizational culture, continuous quality improvement, and medication administration error reporting. AN - 71057040; 11477957 AB - This study explores the relationships among measures of nurses' perceptions of organizational culture, continuous quality improvement (CQI) implementation, and medication administration error (MAE) reporting. Hospital-based nurses were surveyed using measures of organizational culture and CQI implementation. These data were combined with previously collected data on perceptions of MAE reporting. A group-oriented culture had a significant positive correlation with CQI implementation, whereas hierarchical and rational culture types were negatively correlated with CQI implementation. Higher barriers to reporting MAE were associated with lower perceived reporting rates. A group-oriented culture and a greater extent of CQI implementation were positively (but not significantly) associated with the estimated overall percentage of MAEs reported. We conclude that health care organizations have implemented CQI programs, yet barriers remain relative to MAE reporting. There is a need to assess the reliability, validity, and completeness of key quality assessment and risk management data. JF - American journal of medical quality : the official journal of the American College of Medical Quality AU - Wakefield, B J AU - Blegen, M A AU - Uden-Holman, T AU - Vaughn, T AU - Chrischilles, E AU - Wakefield, D S AD - Iowa City VA Medical Center, 601 Hwy 6 W, Iowa City, IA 52246, USA. bonnie.wakefield@med.va.gov PY - 2001 SP - 128 EP - 134 VL - 16 IS - 4 SN - 1062-8606, 1062-8606 KW - Index Medicus KW - United States KW - Humans KW - Data Collection KW - Adverse Drug Reaction Reporting Systems -- utilization KW - Nursing Staff, Hospital KW - Attitude of Health Personnel KW - Medication Errors -- prevention & control KW - Organizational Culture KW - Total Quality Management -- organization & administration KW - Risk Management -- utilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71057040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+medical+quality+%3A+the+official+journal+of+the+American+College+of+Medical+Quality&rft.atitle=Organizational+culture%2C+continuous+quality+improvement%2C+and+medication+administration+error+reporting.&rft.au=Wakefield%2C+B+J%3BBlegen%2C+M+A%3BUden-Holman%2C+T%3BVaughn%2C+T%3BChrischilles%2C+E%3BWakefield%2C+D+S&rft.aulast=Wakefield&rft.aufirst=B&rft.date=2001-07-01&rft.volume=16&rft.issue=4&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=American+journal+of+medical+quality+%3A+the+official+journal+of+the+American+College+of+Medical+Quality&rft.issn=10628606&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-23 N1 - Date created - 2001-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pilot trial of indinavir, ritonavir, didanosine, and lamivudine in a once-daily four-drug regimen for HIV infection. AN - 71015082; 11464145 AB - To evaluate the tolerance, pharmacokinetics, and virologic and immunologic outcomes of once-daily indinavir, ritonavir, didanosine, and lamivudine in HIV-seropositive individuals. Open-label 24-week pilot study. Ten HIV-seropositive subjects who were either antiretroviral-naive or minimally experienced with short-term single-or dual-nucleoside therapy provided informed consent and were enrolled. All subjects received didanosine (400 mg) 30 to 60 minutes before a meal followed by indinavir (1200 mg), ritonavir (400 mg), and lamivudine (300 mg) concurrent with the aforementioned meal. Safety laboratory tests, including a complete blood cell count and amylase, lipase, liver transaminase, and nonfasting lipid monitoring as well as plasma HIV viral load and CD4+ lymphocyte count, were carried out at monthly intervals. Genotyping was performed at baseline. Pharmacokinetic studies for indinavir and ritonavir were performed at week 8. Nine of 10 subjects completed 24 weeks of therapy. No subject demonstrated primary protease inhibitor mutations at baseline. Toxicities experienced by subjects were typically mild and consistent with those commonly reported for each of the medications, including two cases of hematuria. By week 24, median nonfasting cholesterol and triglyceride levels increased by 49% and 108%, respectively. Median baseline plasma HIV viral load and CD4+ lymphocyte count were 29,292 (4.47 log10) copies/ml and 224 cells/mm3, respectively. Eight of 10 subjects had a plasma HIV viral load of <50 copies/ml by week 12. The 2 subjects with a detectable HIV viral load reached <50 copies/ml by week 28. Median CD4+ lymphocyte counts increased by 193 cells/mm3 at week 24. Indinavir and ritonavir plasma concentrations remained above respective inhibitory and effective concentrations (IC95 and EC50) (uncorrected for protein binding) throughout the 24-hour dosing interval for 6 of 10 and 8 of 10 subjects, respectively. Our pilot study demonstrates excellent virologic suppression despite low minimum protease inhibitor concentrations during a dosing interval in some patients and is supportive of further study. JF - Journal of acquired immune deficiency syndromes (1999) AU - Mole, L AU - Schmidgall, D AU - Holodniy, M AD - Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA. larry.mole@med.va.gov Y1 - 2001/07/01/ PY - 2001 DA - 2001 Jul 01 SP - 260 EP - 265 VL - 27 IS - 3 SN - 1525-4135, 1525-4135 KW - Anti-HIV Agents KW - 0 KW - HIV Protease Inhibitors KW - Triglycerides KW - Lamivudine KW - 2T8Q726O95 KW - Indinavir KW - 5W6YA9PKKH KW - Cholesterol KW - 97C5T2UQ7J KW - Didanosine KW - K3GDH6OH08 KW - Ritonavir KW - O3J8G9O825 KW - Index Medicus KW - AIDS/HIV KW - Triglycerides -- blood KW - Humans KW - Indinavir -- therapeutic use KW - Lamivudine -- therapeutic use KW - Pilot Projects KW - CD4 Lymphocyte Count KW - Indinavir -- adverse effects KW - Didanosine -- adverse effects KW - Ritonavir -- therapeutic use KW - Adult KW - Indinavir -- pharmacokinetics KW - Treatment Outcome KW - Ritonavir -- adverse effects KW - Male KW - Ritonavir -- pharmacokinetics KW - Lamivudine -- adverse effects KW - Safety KW - Didanosine -- pharmacokinetics KW - Viral Load KW - Genotype KW - Drug Therapy, Combination KW - Drug Evaluation KW - Didanosine -- therapeutic use KW - Cholesterol -- blood KW - Lamivudine -- pharmacokinetics KW - Middle Aged KW - Anti-HIV Agents -- pharmacokinetics KW - HIV Infections -- virology KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- immunology KW - HIV Infections -- drug therapy KW - Anti-HIV Agents -- adverse effects KW - HIV Protease Inhibitors -- pharmacokinetics KW - HIV Protease Inhibitors -- therapeutic use KW - HIV Protease Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71015082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=A+pilot+trial+of+indinavir%2C+ritonavir%2C+didanosine%2C+and+lamivudine+in+a+once-daily+four-drug+regimen+for+HIV+infection.&rft.au=Mole%2C+L%3BSchmidgall%2C+D%3BHolodniy%2C+M&rft.aulast=Mole&rft.aufirst=L&rft.date=2001-07-01&rft.volume=27&rft.issue=3&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=15254135&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-09 N1 - Date created - 2001-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fenofibrate and warfarin interaction. AN - 70984060; 11444587 AB - A 79-year-old man with atrial fibrillation and coronary heart disease who was taking warfarin (Coumadin) was converted to fenofibrate from gemfibrozil therapy for persistently elevated triglyceride levels. The patient took fenofibrate for 1 month and subsequently experienced rectal bleeding that required a visit to the emergency room. Before starting fenofibrate therapy, his coagulation values were within therapeutic range, but when measured in the emergency room the international normalized ratio (INR) was grossly elevated. The patient denied any changes in diet, alcohol ingestion, compliance with therapy, or use of other new drugs except for fenofibrate. His drug therapy profile consisted of digoxin, fosinopril, and furosemide for chronic heart failure, allopurinol for gout, and potassium supplementation. To minimize the risk of supratherapeutic INR values and/or hemorrhagic events, clinicians should perform serial monitoring of INR when initiating fenofibrate therapy in a patient previously stabilized on a coumarin anticoagulant. JF - Pharmacotherapy AU - Aldridge, M A AU - Ito, M K AD - University of Pacific, Stockton, California, and Veterans Administration San Diego Healthcare System, USA. Y1 - 2001/07// PY - 2001 DA - July 2001 SP - 886 EP - 889 VL - 21 IS - 7 SN - 0277-0008, 0277-0008 KW - Anticoagulants KW - 0 KW - Hypolipidemic Agents KW - Warfarin KW - 5Q7ZVV76EI KW - Fenofibrate KW - U202363UOS KW - Index Medicus KW - Blood Coagulation -- physiology KW - Humans KW - Blood Coagulation -- drug effects KW - International Normalized Ratio KW - Aged KW - Drug Synergism KW - Male KW - Drug Interactions -- physiology KW - Anticoagulants -- pharmacokinetics KW - Warfarin -- pharmacokinetics KW - Fenofibrate -- pharmacokinetics KW - Hypolipidemic Agents -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70984060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Fenofibrate+and+warfarin+interaction.&rft.au=Aldridge%2C+M+A%3BIto%2C+M+K&rft.aulast=Aldridge&rft.aufirst=M&rft.date=2001-07-01&rft.volume=21&rft.issue=7&rft.spage=886&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase I study of anti--epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer. AN - 70978686; 11432891 AB - To evaluate the safety, pharmacokinetics, and efficacy of a chimeric anti-epidermal growth factor receptor monoclonal antibody, cetuximab, in combination with radiation therapy (RT) in patients with advanced squamous cell carcinoma of the head and neck. We treated 16 patients in five successive treatment schedules. A standard dose escalation procedure was used; three patients entered onto the study at each dose level of cetuximab received conventional RT (70 Gy, 2 Gy/d), and the final three patients received hyperfractionated RT (76.8 Gy, 1.2 Gy bid). Cetuximab was delivered as a loading dose of 100 to 500 mg/m(2), followed by weekly infusions of 100 to 250 mg/m(2) for 7 to 8 weeks. Circulating levels of cetuximab during therapy were determined using a biomolecular interaction analysis core instrument. Human antichimeric antibody response was evaluated with a double-antigen radiometric assay. The recommended phase II/III dose was defined as the optimal cetuximab dose level based on the pharmacologic parameters and adverse events. The most commonly reported adverse events were fever, asthenia, transaminase elevation, nausea, and skin toxicities (grade 1 to 2 in most patients). Skin toxicity outside of the RT field was not strictly dose-dependent; however, grade 2 or higher events were observed in patients treated with higher dose regimens. There was one grade 4 allergic reaction. Most acute adverse effects were associated with RT (xerostomia, mucositis, and local skin toxicity). No antibodies against cetuximab were detected. All patients achieved an objective response (13 complete and two partial remissions). Cetuximab can be safely administered with RT. The recommended dose for phase II/III studies is a loading dose of 400 to 500 mg/m(2) and a maintenance weekly dose of 250 mg/m(2). JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Robert, F AU - Ezekiel, M P AU - Spencer, S A AU - Meredith, R F AU - Bonner, J A AU - Khazaeli, M B AU - Saleh, M N AU - Carey, D AU - LoBuglio, A F AU - Wheeler, R H AU - Cooper, M R AU - Waksal, H W AD - Division of Hematology/Oncology, Department of Radiation Oncology, Comprehensive Cancer Center, University of Alabama at Birmingham, and Birmingham Veterans Administration, 35294-3330, USA. pacorobertuab@cs.com Y1 - 2001/07/01/ PY - 2001 DA - 2001 Jul 01 SP - 3234 EP - 3243 VL - 19 IS - 13 SN - 0732-183X, 0732-183X KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antineoplastic Agents KW - Cetuximab KW - PQX0D8J21J KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Combined Modality Therapy KW - Humans KW - Adult KW - Metabolic Clearance Rate KW - Aged KW - Middle Aged KW - Male KW - Female KW - Head and Neck Neoplasms -- therapy KW - Radiotherapy -- methods KW - Antibodies, Monoclonal -- pharmacology KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Carcinoma, Squamous Cell -- therapy KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70978686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+I+study+of+anti--epidermal+growth+factor+receptor+antibody+cetuximab+in+combination+with+radiation+therapy+in+patients+with+advanced+head+and+neck+cancer.&rft.au=Robert%2C+F%3BEzekiel%2C+M+P%3BSpencer%2C+S+A%3BMeredith%2C+R+F%3BBonner%2C+J+A%3BKhazaeli%2C+M+B%3BSaleh%2C+M+N%3BCarey%2C+D%3BLoBuglio%2C+A+F%3BWheeler%2C+R+H%3BCooper%2C+M+R%3BWaksal%2C+H+W&rft.aulast=Robert&rft.aufirst=F&rft.date=2001-07-01&rft.volume=19&rft.issue=13&rft.spage=3234&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-19 N1 - Date created - 2001-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Trauma, symptoms of posttraumatic stress disorder, and associated problems among incarcerated veterans. AN - 70966460; 11433115 AB - To help improve treatment for incarcerated veterans, the study examined exposure to trauma, symptoms of posttraumatic stress disorder (PTSD), functional status, and treatment history in a group of incarcerated veterans. A convenience sample of 129 jailed veterans who agreed to receive outreach contact completed the Life Event History Questionnaire, the PTSD Checklist-Civilian Version (PCL-C), and the Addiction Severity Index. Participants who had scores of 50 or above on the PCL-C, designated as screening positive for PTSD, were compared with those whose scores were below 50, designated as screening negative for PTSD. Some 112 veterans (87 percent) reported traumatic experiences. A total of 51 veterans (39 percent) screened positive for PTSD, and 78 veterans (60 percent) screened negative. Compared with veterans who screened negative for PTSD, those who screened positive reported a greater variety of traumas; more serious current legal problems; a higher lifetime use of alcohol, cocaine, and heroin; higher recent expenditures on drugs; more psychiatric symptoms; and worse general health despite more previous psychiatric and medical treatment as well as treatment for substance abuse. The findings encourage the development of an improved treatment model to keep jailed veterans with PTSD from repeated incarceration. JF - Psychiatric services (Washington, D.C.) AU - Saxon, A J AU - Davis, T M AU - Sloan, K L AU - McKnight, K M AU - McFall, M E AU - Kivlahan, D R AD - Center of Excellence in Substance Abuse Treatment and Education in Seatle, USA. andrew.saxon@med.va.gov Y1 - 2001/07// PY - 2001 DA - July 2001 SP - 959 EP - 964 VL - 52 IS - 7 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - Washington -- epidemiology KW - Humans KW - Health Status KW - Adult KW - Sampling Studies KW - Middle Aged KW - Male KW - Comorbidity KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Prisons KW - Veterans -- statistics & numerical data KW - Stress Disorders, Post-Traumatic -- therapy KW - Stress Disorders, Post-Traumatic -- psychology KW - Life Change Events KW - Substance-Related Disorders -- etiology KW - Veterans -- psychology KW - Crime -- statistics & numerical data KW - Crime -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70966460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Trauma%2C+symptoms+of+posttraumatic+stress+disorder%2C+and+associated+problems+among+incarcerated+veterans.&rft.au=Saxon%2C+A+J%3BDavis%2C+T+M%3BSloan%2C+K+L%3BMcKnight%2C+K+M%3BMcFall%2C+M+E%3BKivlahan%2C+D+R&rft.aulast=Saxon&rft.aufirst=A&rft.date=2001-07-01&rft.volume=52&rft.issue=7&rft.spage=959&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-30 N1 - Date created - 2001-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ventral incisional hernia recurrence. AN - 70960403; 11421601 AB - During the period October 1993 to December 1996, 31 patients were operated on by the author for primary or recurrent ventral incisional hernia (VIH). Three patients were excluded from analysis because their records were unavailable for review. The median age of the 28 remaining patients at their initial procedure was 57.5 years (range, 37-78 years). The repair was performed with interrupted O-Ethibond sutures in all but 3 cases where Prolene suture was used secondary to noniatrogenic contamination or recurrent hernia. There were no unplanned enterotomies in the entire series and prophylactic intravenous antibiotics were used in all cases. The only significant complications were skin hyperemia after five repairs in 3 patients who were treated empirically with intravenous antibiotics, and 1 patient who had an antibiotic-associated rash. There were no 30-day mortalities. Prolene mesh was used exclusively in all repairs performed with mesh. Seven of these repairs (25%) were for recurrent VIH. Three of these seven patients had previous mesh repairs. Six of these seven patients who presented with recurrent VIH had a mesh repair and four developed a recurrence. Five of seven were active smokers, with one having severe obstructive lung disease. Four of seven related significant occupational lifting. Of the 21 patients having initial repair of VIH, mesh was used in 8 (38%). After a median follow-up of 13 months, there were 2 recurrent hernias (25%). The remaining 13 patients had primary closure of their hernias. After median follow-up of 25 months, there were 5 recurrences (38%). A total of 34 VIH repairs were performed on these 28 patients, of which 13 were for recurrent hernias. Five of thirteen (38%) of the mesh repairs for recurrent VIH failed. The median body mass index (BMI) for the 13 patients having primary repair was 26.4, and that for all 21 cases having mesh repair was 28.8. Patients with recurrent VIH frequently recur despite use of mesh, avoidance of contamination, and consistent technique. No difference in BMI was apparent in those who recurred. Continued smoking and occupational lifting may be important risk factors for recurrent VIH. Copyright 2001 Academic Press. JF - The Journal of surgical research AU - Clark, J L AD - Surgery Service, Department of Veterans Affairs, Minneapolis Veterans Administration Medical Center, One Veterans Drive, Minneapolis, Minnesota 55417, USA. Y1 - 2001/07// PY - 2001 DA - July 2001 SP - 33 EP - 39 VL - 99 IS - 1 SN - 0022-4804, 0022-4804 KW - Ethibond KW - 0 KW - Polyethylene Terephthalates KW - Polypropylenes KW - Index Medicus KW - Sutures KW - Humans KW - Occupational Diseases -- etiology KW - Retrospective Studies KW - Smoking -- adverse effects KW - Aged KW - Recurrence KW - Risk Factors KW - Adult KW - Treatment Outcome KW - Follow-Up Studies KW - Middle Aged KW - Weight Lifting KW - Surgical Mesh KW - Male KW - Hernia, Ventral -- etiology KW - Hernia, Ventral -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70960403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+surgical+research&rft.atitle=Ventral+incisional+hernia+recurrence.&rft.au=Clark%2C+J+L&rft.aulast=Clark&rft.aufirst=J&rft.date=2001-07-01&rft.volume=99&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+surgical+research&rft.issn=00224804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-02 N1 - Date created - 2001-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Loop diuretic infusion increases thiazide-sensitive Na(+)/Cl(-)-cotransporter abundance: role of aldosterone. AN - 70949813; 11423562 AB - Chronic infusion of loop diuretics into animals induces structural and functional changes in the distal nephron. These changes include increases in the activity of the thiazide-sensitive Na(+)/Cl(-)-cotransporter (NCC). The NCC was recently demonstrated to be an aldosterone-induced protein. These experiments were designed to test the hypotheses that chronic loop diuretic infusion, with replacement of NaCl losses, increases NCC protein abundance and that this effect results, in part, from stimulation by aldosterone. Sprague-Dawley rats received vehicle (group 1), furosemide (22 mg/100 g body wt per d) (group 2), or furosemide plus spironolactone (22 and 20 mg/100 g body wt per d, respectively) (group 3). Urine output was higher for groups 2 and 3 than for group 1 (151 +/- 32, 149 +/- 24, and 12 +/- 4 ml, respectively; P 0.05, NS) These results indicate that increased NCC activity during chronic loop diuretic infusion is associated with increases in NCC protein abundance. A portion of the furosemide effect can be prevented by blockade of mineralocorticoid receptors. JF - Journal of the American Society of Nephrology : JASN AU - Abdallah, J G AU - Schrier, R W AU - Edelstein, C AU - Jennings, S D AU - Wyse, B AU - Ellison, D H AD - Division of Nephrology and Hypertension, University of Colorado School of Medicine and Veterans Administration Medical Center, Denver, Colorado, USA. Y1 - 2001/07// PY - 2001 DA - July 2001 SP - 1335 EP - 1341 VL - 12 IS - 7 SN - 1046-6673, 1046-6673 KW - Carrier Proteins KW - 0 KW - Diuretics KW - RNA, Messenger KW - Receptors, Drug KW - Slc12a3 protein, rat KW - Sodium Chloride Symporters KW - Solute Carrier Family 12, Member 3 KW - Symporters KW - thiazide receptor KW - Spironolactone KW - 27O7W4T232 KW - Aldosterone KW - 4964P6T9RB KW - Furosemide KW - 7LXU5N7ZO5 KW - Index Medicus KW - Rats KW - Metabolism -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - RNA, Messenger -- metabolism KW - Drug Synergism KW - Male KW - Spironolactone -- pharmacology KW - Receptors, Drug -- genetics KW - Receptors, Drug -- metabolism KW - Carrier Proteins -- metabolism KW - Carrier Proteins -- genetics KW - Diuretics -- pharmacology KW - Furosemide -- pharmacology KW - Aldosterone -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70949813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=Loop+diuretic+infusion+increases+thiazide-sensitive+Na%28%2B%29%2FCl%28-%29-cotransporter+abundance%3A+role+of+aldosterone.&rft.au=Abdallah%2C+J+G%3BSchrier%2C+R+W%3BEdelstein%2C+C%3BJennings%2C+S+D%3BWyse%2C+B%3BEllison%2C+D+H&rft.aulast=Abdallah&rft.aufirst=J&rft.date=2001-07-01&rft.volume=12&rft.issue=7&rft.spage=1335&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-30 N1 - Date created - 2001-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Attachment Style Classification and Posttraumatic Stress Disorder in Former Prisoners of War AN - 61508695; 200104424 AB - Adult attachment style & posttraumatic stress disorder (PTSD) symptomatology were investigated in 107 former prisoner of war veterans. Those with secure attachment styles scored significantly lower on measures of PTSD than did those with insecure styles, & attachment style was a stronger predictor of PTSD symptom intensity than was trauma severity. The suggested association between attachment style & PTSD's development & persistence are discussed in relation to research & clinical practice. 2 Tables, 24 References. Adapted from the source document. JF - American Journal of Orthopsychiatry AU - Dieperink, Michael AU - Leskela, Jennie AU - Thuras, Paul AU - Engdahl, Brian AD - c/o Leskela -- Dept Veterans Affairs Medical Center, Minneapolis, MN Y1 - 2001/07// PY - 2001 DA - July 2001 SP - 374 EP - 378 VL - 71 IS - 3 SN - 0002-9432, 0002-9432 KW - Veterans KW - Attachment KW - Prisoners of War KW - Posttraumatic Stress Disorder KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61508695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Orthopsychiatry&rft.atitle=Attachment+Style+Classification+and+Posttraumatic+Stress+Disorder+in+Former+Prisoners+of+War&rft.au=Dieperink%2C+Michael%3BLeskela%2C+Jennie%3BThuras%2C+Paul%3BEngdahl%2C+Brian&rft.aulast=Dieperink&rft.aufirst=Michael&rft.date=2001-07-01&rft.volume=71&rft.issue=3&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Orthopsychiatry&rft.issn=00029432&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJORAG N1 - SubjectsTermNotLitGenreText - Attachment; Posttraumatic Stress Disorder; Veterans; Prisoners of War ER - TY - JOUR T1 - Longitudinal follow-up of depressive symptoms among normal versus cognitively impaired elderly AN - 21105810; 11319089 AB - Objectives This prospectively designed longitudinal study assesses prevalence, incidence and prognosis of depressive symptoms among cognitively normal elderly volunteers compared with patients with mild cognitive impairment (MCI), dementia of Alzheimer type (DAT), and vascular dementia (VAD). Possible relationships between depressive symptoms, cognitive performance, disease types, and effects of antidepressant treatment were analyzed. Methods Two hundred and ninety four subjects exhibiting different levels of cognitive performance were admitted to this study. Demographics, cardiovascular and neurodegenerative risk factors, together with measures of neuropsychological test performance, were obtained at sequential visits. Depressive symptoms were selectively treated with antidepressant medications. Results One hundred and forty six subjects with normal cognition, 19 subjects with MCI, 42 patients with DAT, and 32 patients with VAD were followed for a mean of 3.5 years. With the passage of time, there were trends showing prevalence of depressive symptoms to decrease among DAT and to increase among VAD patients. VAD patients exhibited the highest incidences of new-onset depressive symptoms, followed in incidence by DAT and MCI groups. Depressive symptoms among VAD and MCI patients were more persistent and refractory to antidepressant medications than for DAT patients. Trends suggested that antidepressant treatment might benefit MCI and VAD subjects more than DAT patients. Motivationally related depressive symptoms accounted for major components of elevated Hamilton depression rating scale scores. Conclusions Depressive symptoms among DAT patients have higher rates of spontaneous resolution, without requiring intensive drug treatment, than among VAD patients in whom depressive symptoms are more persistent and refractory to drug treatment. Early depressive symptoms among subjects with MCI may represent a preclinical sign and should be considered as a risk factor for impending DAT or VAD among the elderly. JF - International Journal of Geriatric Psychiatry AU - Li, Yan-Sheng AU - Meyer, John S AU - Thornby, John AD - Cerebrovascular Research Laboratories, Veterans Administration Medical Center, Houston, TX, USA and Department of Neurology, Baylor College of Medicine, Houston, TX, USA, jmeyer@bcm.tmc.edu Y1 - 2001/07// PY - 2001 DA - Jul 2001 SP - 718 EP - 727 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 16 IS - 7 SN - 0885-6230, 0885-6230 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - demography KW - Alzheimer's disease KW - vascular dementia KW - Demography KW - Risk factors KW - antidepressants KW - Dementia disorders KW - Geriatrics KW - Drugs KW - Depression KW - Prognosis KW - depression KW - Neurodegenerative diseases KW - Antidepressants KW - cognitive ability KW - Cognitive ability KW - dementia disorders KW - Cardiovascular diseases KW - elderly KW - longitudinal studies KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21105810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Geriatric+Psychiatry&rft.atitle=Longitudinal+follow-up+of+depressive+symptoms+among+normal+versus+cognitively+impaired+elderly&rft.au=Li%2C+Yan-Sheng%3BMeyer%2C+John+S%3BThornby%2C+John&rft.aulast=Li&rft.aufirst=Yan-Sheng&rft.date=2001-07-01&rft.volume=16&rft.issue=7&rft.spage=718&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Geriatric+Psychiatry&rft.issn=08856230&rft_id=info:doi/10.1002%2Fgps.423 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Depression; Alzheimer's disease; Prognosis; vascular dementia; Demography; Antidepressants; Neurodegenerative diseases; Cognitive ability; Risk factors; Dementia disorders; Geriatrics; Cardiovascular diseases; Drugs; demography; cognitive ability; antidepressants; dementia disorders; elderly; depression; longitudinal studies DO - http://dx.doi.org/10.1002/gps.423 ER - TY - JOUR T1 - Decreased expression of the NADH:ubiquinone oxidoreductase (complex I) subunit 4 in 1-methyl-4-phenylpyridinium -treated human neuroblastoma SH-SY5Y cells. AN - 70920770; 11406316 AB - Oxidative stress and mitochondrial dysfunction have been implicated in Parkinson's disease (PD) pathology. NADH:ubiquinone oxidoreductase (complex I) (EC 1.6.99.3) enzyme activity is aberrant in both PD and 1-methyl-4-phenylpyridinium (MPP(+)) models of PD. Reverse transcription polymerase chain reaction of RNA isolated from MPP(+)-treated human neuroblastoma SH-SY5Y cells identified changes in steady-state mRNA levels of the mitochondrial transcript for subunit 4 of complex I (ND4). Expression of ND4 decreased to nearly 50% after 72 h of MPP(+) (1 mM) exposure. The expression of other mitochondrial transcripts did not change significantly under the same conditions. Pre-incubation of cells with the free-radical spin-trap, N-tert-butyl-alpha-(2-sulfophenyl)-nitrone prior to MPP(+) exposure, prevented decreases in cell viability and ND4 expression. This suggests that functional defects in complex I enzyme activity in PD and MPP(+) toxicity may result from changes in steady-state mRNA levels and that free radicals may be important in this process. JF - Neuroscience letters AU - Conn, K J AU - Ullman, M D AU - Eisenhauer, P B AU - Fine, R E AU - Wells, J M AD - Department of Veterans Affairs, VA Medical Center, 200 Springs Road, Bedford, MA 01730, USA. conn.kelly_j@bedford.va.gov Y1 - 2001/06/29/ PY - 2001 DA - 2001 Jun 29 SP - 145 EP - 148 VL - 306 IS - 3 SN - 0304-3940, 0304-3940 KW - Herbicides KW - 0 KW - RNA, Messenger KW - NADH, NADPH Oxidoreductases KW - EC 1.6.- KW - Electron Transport Complex I KW - EC 1.6.5.3 KW - 1-Methyl-4-phenylpyridinium KW - R865A5OY8J KW - Index Medicus KW - Tumor Cells, Cultured KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Mitochondria -- enzymology KW - Humans KW - Parkinson Disease -- metabolism KW - RNA, Messenger -- analysis KW - Neuroblastoma KW - NADH, NADPH Oxidoreductases -- genetics KW - 1-Methyl-4-phenylpyridinium -- toxicity KW - Neurons -- drug effects KW - Neurons -- physiology KW - Herbicides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70920770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Decreased+expression+of+the+NADH%3Aubiquinone+oxidoreductase+%28complex+I%29+subunit+4+in+1-methyl-4-phenylpyridinium+-treated+human+neuroblastoma+SH-SY5Y+cells.&rft.au=Conn%2C+K+J%3BUllman%2C+M+D%3BEisenhauer%2C+P+B%3BFine%2C+R+E%3BWells%2C+J+M&rft.aulast=Conn&rft.aufirst=K&rft.date=2001-06-29&rft.volume=306&rft.issue=3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-02 N1 - Date created - 2001-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - fMRI study of face emotion processing: An analysis of functional connectivity in healthy and anxious adults AN - 39348024; 3599506 AU - Goldin, P AU - Brown, G AU - Zorilla, LE AU - Stein, M Y1 - 2001/06/22/ PY - 2001 DA - 2001 Jun 22 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39348024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=fMRI+study+of+face+emotion+processing%3A+An+analysis+of+functional+connectivity+in+healthy+and+anxious+adults&rft.au=Goldin%2C+P%3BBrown%2C+G%3BZorilla%2C+LE%3BStein%2C+M&rft.aulast=Goldin&rft.aufirst=P&rft.date=2001-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Cognitive Nueroscience Society, 6162 Moore Hall, Dartmouth College, Hanover, NH 03755, USA; phone: 603-646-1189; email: cns@dartmouth.edu; URL: www.dartmouth.edu/~cns. Poster Paper No. 56A N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical diagnosis, outbreak investigation, and surveillance of odor and irritancy problems in the workplace: Tools, predictive value, and decision logic AN - 39337532; 3606186 AU - Hodgson, MJ Y1 - 2001/06/22/ PY - 2001 DA - 2001 Jun 22 KW - CPI, Conference Papers Index KW - U 4300:Environmental Science KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39337532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Clinical+diagnosis%2C+outbreak+investigation%2C+and+surveillance+of+odor+and+irritancy+problems+in+the+workplace%3A+Tools%2C+predictive+value%2C+and+decision+logic&rft.au=Hodgson%2C+MJ&rft.aulast=Hodgson&rft.aufirst=MJ&rft.date=2001-06-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; URL: www.toxicology.org. Paper No. #649 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Colonocyte Basolateral Membranes Contain Escherichia coli Heat-Stable Enterotoxin Receptors AN - 18183855; 5131502 AB - Heat-stable enterotoxin (ST sub(a)) elaborated by E. coli is a major cause of diarrhea. The transmembrane protein guanylyl cyclase C (GC-C) is the acknowledged receptor for ST sub(a) and for the mammalian peptides guanylin and uroguanylin. Binding to GC-C results in generation of cGMP, activation of type II cGMP-dependent protein kinase, phosphorylation of CFTR and increased chloride and bicarbonate secretion. We had previously shown that ST sub(a) receptors (GC-C) are found on the brush border membranes of small intestinal enterocytes and of colonocytes. However, since it has subsequently been shown that the endogenous ligands for these receptors, guanylin and uroguanylin, circulate in blood, we proposed the existence of ST sub(a) binding sites on the basolateral membranes (BLM) of colonocytes. Specific binding of super(125)I-ST sub(a) to rat colonocyte BLM was seen. The kinetics of binding to the BLM were similar to binding to BBM. The nature of the BLM receptor is unknown. This suggests that circulating guanylin and uroguanylin, analogues of ST sub(a), may also function via the basolateral surface. Copyright 2001 Academic Press. JF - Biochemical and Biophysical Research Communications AU - Albano, F AU - Brasitus, T AU - Mann, E A AU - Guarino, A AU - Giannella, R A AD - Division of Digestive Diseases, University of Cincinnati, Veterans Administration Medical Center, Cincinnati, Ohio, ralph.giannella@uc.edu Y1 - 2001/06/08/ PY - 2001 DA - 2001 Jun 08 SP - 331 EP - 334 PB - Academic Press VL - 284 IS - 2 SN - 0006-291X, 0006-291X KW - binding KW - colonocytes KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Diarrhea KW - Gastrointestinal tract diseases KW - Heat tolerance KW - Cell membranes KW - Escherichia coli KW - Enterotoxins KW - X 24171:Microbial KW - J 02823:In vitro and in vivo effects KW - J 02846:Gastrointestinal tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18183855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Colonocyte+Basolateral+Membranes+Contain+Escherichia+coli+Heat-Stable+Enterotoxin+Receptors&rft.au=Albano%2C+F%3BBrasitus%2C+T%3BMann%2C+E+A%3BGuarino%2C+A%3BGiannella%2C+R+A&rft.aulast=Albano&rft.aufirst=F&rft.date=2001-06-08&rft.volume=284&rft.issue=2&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1006%2Fbbrc.2001.4973 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Enterotoxins; Heat tolerance; Diarrhea; Gastrointestinal tract diseases; Cell membranes DO - http://dx.doi.org/10.1006/bbrc.2001.4973 ER - TY - JOUR T1 - Allergic fungal rhinosinusitis: current theories and management strategies. AN - 85347591; pmid-11404613 AB - The combination of nasal polyposis, crust formation, and sinus cultures yielding Aspergillus was first noted in 1976 by Safirstein,1 who observed the clinical similarity that this constellation of findings shared with allergic bronchopulmonary Aspergillosis (ABPA). Eventually this disease came to be known as allergic fungal rhinosinusitis (AFS). As clinical evidence of AFS accumulated, controversy regarding its etiology, pathogenesis, natural history, and appropriate treatment naturally emerged. Despite past and current efforts, many of these controversies remain incompletely resolved, but continuing clinical study has illuminated some aspects of the disease and has led to an improved understanding of AFS and its treatment. Fungi associated with the development of AFS are ubiquitous and predominantly of the dematiaceous family. The eosinophilic host response to the presence of these fungi within the nose and paranasal sinuses gives rise to those clinical manifestations of the disease (nasal polyps, expansile mucocele formation, allergic fungal mucin, etc.). Exposure alone to these fungi, however, appears to be insufficient to initiate the disease. At the present time it is likely that initiation of the inflammatory cascade leading to AFS is a multifactorial event, requiring the simultaneous occurrence of such things as IgE-mediated sensitivity (atopy), specific T-cell HLA receptor expression, exposure to specific fungi, and aberration of local mucosal defense mechanisms. A variety of treatment plans for AFS have emerged, but the potential for recidivism remains well recognized, ranging from 10% to nearly 100%, suggesting the need for continued study of this disease and fueling present controversy. This article is intended to review current data and theories regarding the pathophysiology of AFS, as well as the role of various surgical and nonsurgical forms of therapy. JF - The Laryngoscope AU - Marple, B F AD - Department of Otolaryngology, Dallas Veterans Administration Hospital and Parkland Memorial Hospital, Dallas, Texas, USA. Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 1006 EP - 1019 VL - 111 IS - 6 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - *Aspergillosis, Allergic Bronchopulmonary: diagnosis KW - Aspergillosis, Allergic Bronchopulmonary: therapy KW - Humans KW - Recurrence KW - *Rhinitis: diagnosis KW - Rhinitis: therapy KW - *Sinusitis: diagnosis KW - Sinusitis: therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85347591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Allergic+fungal+rhinosinusitis%3A+current+theories+and+management+strategies.&rft.au=Marple%2C+B+F&rft.aulast=Marple&rft.aufirst=B&rft.date=2001-06-01&rft.volume=111&rft.issue=6&rft.spage=1006&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Correlates of expressed and received violence across relationship types among men and women substance abusers. AN - 70944248; 11419230 AB - This study examined expressed and received violence among men and women in substance abuse treatment. Rates of past-year partner violence (PV) did not differ by gender, although men reported markedly higher rates of nonpartner violence (NPV). Compared with PV, NPV was associated with more demographic and background factors (e.g., childhood aggression and conduct problems, family history of violence). The most consistent correlates of violence across relationship types were age, minority status, drug-related consequences, psychiatric distress, and frequency of childhood aggression. Only a few gender-specific correlates were identified; most notably, witnessing father-to-mother violence was related to received PV only for women. Identification of correlates of expressed and received violence in partner and nonpartner relationships is essential for the assessment and treatment of individuals in substance abuse treatment settings. JF - Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors AU - Chermack, S T AU - Walton, M A AU - Fuller, B E AU - Blow, F C AD - Psychiatry Service, John D. Dingell Veterans Affairs Medical Center, 4646 John R. Street, Detroit, Michigan 48201, USA. stephen.chermack@med.va.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 140 EP - 151 VL - 15 IS - 2 SN - 0893-164X, 0893-164X KW - Index Medicus KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Male KW - Female KW - Stress, Psychological -- psychology KW - Interpersonal Relations KW - Affect KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Violence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70944248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+addictive+behaviors+%3A+journal+of+the+Society+of+Psychologists+in+Addictive+Behaviors&rft.atitle=Correlates+of+expressed+and+received+violence+across+relationship+types+among+men+and+women+substance+abusers.&rft.au=Chermack%2C+S+T%3BWalton%2C+M+A%3BFuller%2C+B+E%3BBlow%2C+F+C&rft.aulast=Chermack&rft.aufirst=S&rft.date=2001-06-01&rft.volume=15&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Psychology+of+addictive+behaviors+%3A+journal+of+the+Society+of+Psychologists+in+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-09 N1 - Date created - 2001-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rheumatologists' attitudes toward routine screening for hydroxychloroquine retinopathy. AN - 70927543; 11409112 AB - To examine rheumatologists' attitudes toward routine ophthalmologic screening for hydroxychloroquine (HCQ) retinopathy and to estimate the acceptability of hypothetical guidelines discouraging this practice. We E-mailed a random sample of 300 US rheumatologists listed in the American College of Rheumatology (ACR) Directory who treat adults. We asked about current screening practice, reasons for screening, and the effect of hypothetical guidelines discouraging routine screening on future practice. Associations between adherence to guidelines and clinical variables were evaluated using multiple logistic regression. Of 56% who responded, almost all (94%) currently screen their patients at least once per year. Seventy-five percent stated that they would continue to screen because they are unwilling to accept any risk of visual loss among their patients; 74% would continue to screen because of legal liability; and 56% felt their patients would insist on being screened regardless of their physician's opinion. Forty-four percent stated that they would continue to screen regularly, even if the ACR published guidelines discouraging routine screening. Rheumatologists unwilling to accept any risk of retinopathy were less likely to follow guidelines discouraging screening (46 vs 77%, adjusted OR 0.2, 95% CI 0.1-0.6). Patient insistence and fear of legal liability were not significantly associated with predicted adherence to guidelines. Our survey indicates that the majority of rheumatologists currently routinely screen their patients for HCQ retinopathy, and that many would not follow ACR guidelines discouraging this practice, at least in part because they are unwilling to accept any risk of visual damage. JF - The Journal of rheumatology AU - Fraenkel, L AU - Felson, D T AD - Yale University, Department of Internal Medicine, Section of Rheumatology, PO Box 208031, 333 Cedar Street, New Haven, CT 06520-8031, USA. liana.fraenkel@med.va.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 1218 EP - 1221 VL - 28 IS - 6 SN - 0315-162X, 0315-162X KW - Antirheumatic Agents KW - 0 KW - Hydroxychloroquine KW - 4QWG6N8QKH KW - Index Medicus KW - United States KW - Vision, Low -- chemically induced KW - Humans KW - Professional Practice -- legislation & jurisprudence KW - Liability, Legal KW - Professional Practice -- statistics & numerical data KW - Mass Screening -- psychology KW - Mass Screening -- legislation & jurisprudence KW - Practice Guidelines as Topic KW - Risk Management KW - Mass Screening -- standards KW - Professional Practice -- standards KW - Female KW - Male KW - Rheumatology -- standards KW - Rheumatology -- statistics & numerical data KW - Attitude of Health Personnel KW - Antirheumatic Agents -- toxicity KW - Hydroxychloroquine -- toxicity KW - Retinal Diseases -- chemically induced KW - Rheumatology -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70927543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+rheumatology&rft.atitle=Rheumatologists%27+attitudes+toward+routine+screening+for+hydroxychloroquine+retinopathy.&rft.au=Fraenkel%2C+L%3BFelson%2C+D+T&rft.aulast=Fraenkel&rft.aufirst=L&rft.date=2001-06-01&rft.volume=28&rft.issue=6&rft.spage=1218&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+rheumatology&rft.issn=0315162X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of cidofovir in progressive multifocal leukoencephalopathy. AN - 70924838; 11408993 AB - Progressive multifocal leukoencephalopathy (PML) is a subacute demyelinating illness caused by the JC virus, a polyomavirus that occurs in 4-5% of HIV-positive patients. Mortality is high, and no useful therapy has been identified. Highly active antiretroviral therapy (HAART) has been reported to be effective in halting progression of the disease in some, but not all, patients. Cidofovir has been shown to be active against polyomaviruses. To review data on the use of cidofovir to treat PML. English-language case reports and clinical studies were located through a literature search (MEDLINE and AIDSLINE, 1995-July 2000). Relevant case reports and studies describing the use of cidofovir for PML were reviewed. Most case reports describing the use of cidofovir have shown that the drug is effective in the treatment of PML. Some patients were also receiving HAART concurrently; therefore, it is not clear which treatment modality had a greater impact on PML. However, cidofovir may be effective in patients whose disease has progressed despite HAART or who are-unable to tolerate these regimens. A pilot study of cidofovir for treating PML has completed enrollment, but preliminary results showed no benefit. Cidofovir may be the most reasonable treatment option for PML in HIV-infected individuals who fail to improve with HAART or who are unable to tolerate these regimens. Patients who receive cidofovir should be monitored for renal and ocular toxicity. JF - The Annals of pharmacotherapy AU - Segarra-Newnham, M AU - Vodolo, K M AD - Veterans Affairs Medical Center, West Palm Beach, FL, USA. marisel.segarra-newnham@med.va.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 741 EP - 744 VL - 35 IS - 6 SN - 1060-0280, 1060-0280 KW - Antiviral Agents KW - 0 KW - Organophosphonates KW - Organophosphorus Compounds KW - Cytosine KW - 8J337D1HZY KW - cidofovir KW - JIL713Q00N KW - Index Medicus KW - Humans KW - Treatment Outcome KW - Male KW - Female KW - Antiviral Agents -- therapeutic use KW - Organophosphorus Compounds -- therapeutic use KW - Cytosine -- therapeutic use KW - Leukoencephalopathy, Progressive Multifocal -- drug therapy KW - Cytosine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70924838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Use+of+cidofovir+in+progressive+multifocal+leukoencephalopathy.&rft.au=Segarra-Newnham%2C+M%3BVodolo%2C+K+M&rft.aulast=Segarra-Newnham&rft.aufirst=M&rft.date=2001-06-01&rft.volume=35&rft.issue=6&rft.spage=741&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-18 N1 - Date created - 2001-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuroleptic malignant syndrome during a change from haloperidol to risperidone. AN - 70918745; 11408988 AB - To report a case of neuroleptic malignant syndrome (NMS) in a patient whose therapy was being switched from haloperidol to risperidone. A 57-year-old African-American man, treated for schizophrenia with haloperidol for several years, developed NMS within 48 hours of the addition of low doses of risperidone and mirtazapine to his regimen. Symptoms, which included fever, generalized rigidity, and altered mental status, resolved after discontinuation of psychotropics, supportive management, and several weeks of treatment with bromocriptine and dantrolene. He was subsequently treated with olanzapine without adverse effects. Several cases of NMS have been reported with risperidone, but none under these circumstances. NMS most likely occurred in this patient as a result of the additive dopamine 2 receptor blocking of haloperidol and risperidone. Sympathetic hyperactivity secondary to mirtazapine may also have been a contributing factor. If NMS may be induced by the simultaneous use of older, high-potency antipsychotics and newer, atypical antipsychotics such as risperidone, switching patients from older to newer antipsychotics may at times be difficult, since completely stopping one antipsychotic before starting the second may place patients at risk for psychotic relapse. Clinicians should closely monitor patients receiving both haloperidol and risperidone or combinations of similar medications. JF - The Annals of pharmacotherapy AU - Reeves, R R AU - Mack, J E AU - Torres, R A AD - GV (Sonny) Montgomery Veterans Administration Medical Center, USA. roy.reeves2@med.va.gov Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 698 EP - 701 VL - 35 IS - 6 SN - 1060-0280, 1060-0280 KW - Antipsychotic Agents KW - 0 KW - Haloperidol KW - J6292F8L3D KW - Risperidone KW - L6UH7ZF8HC KW - Index Medicus KW - Humans KW - Schizophrenia -- drug therapy KW - Middle Aged KW - Male KW - Haloperidol -- adverse effects KW - Neuroleptic Malignant Syndrome -- etiology KW - Haloperidol -- therapeutic use KW - Antipsychotic Agents -- therapeutic use KW - Risperidone -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Risperidone -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70918745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Neuroleptic+malignant+syndrome+during+a+change+from+haloperidol+to+risperidone.&rft.au=Reeves%2C+R+R%3BMack%2C+J+E%3BTorres%2C+R+A&rft.aulast=Reeves&rft.aufirst=R&rft.date=2001-06-01&rft.volume=35&rft.issue=6&rft.spage=698&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-18 N1 - Date created - 2001-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Countervailing influence of tumor necrosis factor-alpha and nitric oxide in endotoxemia. AN - 70861978; 11373343 AB - Tumor necrosis factor-alpha (TNF-alpha), a crucial mediator in sepsis, elicits multiple biologic effects, including intravascular thrombosis and circulatory shock. TNF-alpha exerts its biologic effects through two distinct cell surface receptors, TNF-R1 and TNF-R2. The pathophysiologic interaction between TNF-alpha and nitric oxide (NO) in glomerular thrombosis caused by endotoxemia in rats and wild-type mice (C57BL6) as well as in knockout mice that are deficient in TNF-R1 (R1 -/-), TNF-R2 (R2 -/-), or both receptors (R1R2 -/-) was studied. Administration of lipopolysaccharide (LPS; Escherichia coli endotoxin) resulted in increased NO and TNF-alpha production but failed to induce glomerular thrombosis. Concomitant administration of LPS + NG-nitro-L-arginine methyl ester (L-NAME; an NO synthesis inhibitor) resulted in glomerular thrombosis in rats and in wild-type mice. Intraperitoneal administration of pentoxifylline before LPS inhibited TNF-alpha synthesis and prevented glomerular thrombosis in rats given LPS + L-NAME. In contrast to the results observed in rats and wild-type mice, administration of LPS + L-NAME did not result in glomerular thrombosis in knockout mice with either single or double TNF-alpha receptor deletion. Thus, during endotoxemia, (1) TNF-alpha fosters glomerular thrombosis if there is deficiency of NO synthesis and (2) both TNF-alpha receptors are necessary for TNF-alpha's prothrombogenic action. Clinically, these novel studies suggest that in gram-negative endotoxemia, inhibition of NO synthesis and selective blockade of TNF-alpha receptors may provide unique therapeutic approaches for mitigation of glomerular thrombosis and restitution of vascular tone. JF - Journal of the American Society of Nephrology : JASN AU - Jaimes, E A AU - del Castillo, D AU - Rutherford, M S AU - Raij, L AD - Nephrology and Hypertension Section, Veterans Administration Medical Center, Minneapolis, Minnesota 55417, USA. Jaime002@tc.umn.edu. Y1 - 2001/06// PY - 2001 DA - June 2001 SP - 1204 EP - 1210 VL - 12 IS - 6 SN - 1046-6673, 1046-6673 KW - Enzyme Inhibitors KW - 0 KW - Lipopolysaccharides KW - Tumor Necrosis Factor-alpha KW - Nitric Oxide KW - 31C4KY9ESH KW - Pentoxifylline KW - SD6QCT3TSU KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Index Medicus KW - Animals KW - Analysis of Variance KW - NG-Nitroarginine Methyl Ester -- pharmacology KW - Pentoxifylline -- pharmacology KW - Mice KW - Mice, Knockout KW - Rats KW - Rats, Sprague-Dawley KW - Escherichia coli KW - Enzyme Inhibitors -- pharmacology KW - Enzyme-Linked Immunosorbent Assay KW - Lipopolysaccharides -- toxicity KW - Male KW - Thrombosis -- etiology KW - Nitric Oxide -- metabolism KW - Tumor Necrosis Factor-alpha -- metabolism KW - Kidney Glomerulus -- metabolism KW - Endotoxemia -- enzymology KW - Endotoxemia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70861978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=Countervailing+influence+of+tumor+necrosis+factor-alpha+and+nitric+oxide+in+endotoxemia.&rft.au=Jaimes%2C+E+A%3Bdel+Castillo%2C+D%3BRutherford%2C+M+S%3BRaij%2C+L&rft.aulast=Jaimes&rft.aufirst=E&rft.date=2001-06-01&rft.volume=12&rft.issue=6&rft.spage=1204&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-02 N1 - Date created - 2001-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hypersensitivity pneumonitis in a metal-working environment AN - 18086317; 5172819 AB - Background: An outbreak of lung disease among workers in a metal-working plant included 16 biopsy-confirmed cases of hypersensitivity pneumonitis and additional patients with asthma, bronchiolitis and emphysema, usual interstitial pneumonitis, and sarcoidosis. Study design: Clinical examination of patients; cross-sectional questionnaire survey of the outbreak plant and two control plant areas, one with and one without MWF exposures, in a separate facility; industrial hygiene survey with laboratory characterization of microbial flora; and immunological investigation. Methods: Patients with suspected hypersensitivity pneumonitis underwent a clinical examination including detailed lung function, imaging, and tissue studies. A plant walk-through identified metal-working processes, microbial aerosols, and work practices. Microbial characteristics of the three microbial aerosol-producing processes were characterized. Antibodies to those agents were determined in patient sera. A questionnaire survey was conducted in the case plant and in two areas of a control plant, one with and one without metal-working fluids exposure. Results: Thirty-nine (79.6%) patients described symptoms consistent with work-related lung disease, eight received other diagnoses, and two did not complete their examinations. Sixteen patients had hypersensitivity pneumonitis confirmed on biopsy. Mean decrements in lung forced expiratory volume in 1 s and force vital capacity from before to after work were similar in the 16 biopsy-confirmed cases of hypersensitivity pneumonitis ( - 6.3%; - 7.2%) and the 19 symptomatic patients without biopsies ( - 11.2%, - 10.1%). Symptoms were more common in the case plant than in a non-MWF control plant area. Three sources of water-based aerosols were identified that grew similar microbial flora. Although machining increased airborne bacterial levels, the increase was not related to the concentration of viable bacteria in the sumps. Antibody testing did not identify a specific single organisms. Endotoxin levels were similar in case and MWF control plant. Conclusions: Lung disease in environments with water-based aerosols may be more common than usually recognized. Patients with HP often present with only subtle abnormalities and may be missed if multiple clinical abnormalities are required to document disease. JF - American Journal of Industrial Medicine AU - Hodgson, MJ AU - Bracker, A AU - Yang, C AU - Storey, E AU - Jarvis, B J AU - Milton, D AU - Lummus, Z AU - Bernstein, D AU - Cole, S AD - Occupational Health Programs (136), Veterans Health Administration, 810 Vermont Avenue, NW, Washington, DC 20420, USA, muh7@mail.va.gov Y1 - 2001/06// PY - 2001 DA - Jun 2001 SP - 616 EP - 628 VL - 39 IS - 6 SN - 0271-3586, 0271-3586 KW - man KW - hypersensitivity KW - pneumonitis KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Metals KW - Aerosols KW - Lung diseases KW - Respiratory diseases KW - Hypersensitivity KW - Pneumonitis KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - X 24162:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18086317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Hypersensitivity+pneumonitis+in+a+metal-working+environment&rft.au=Hodgson%2C+MJ%3BBracker%2C+A%3BYang%2C+C%3BStorey%2C+E%3BJarvis%2C+B+J%3BMilton%2C+D%3BLummus%2C+Z%3BBernstein%2C+D%3BCole%2C+S&rft.aulast=Hodgson&rft.aufirst=MJ&rft.date=2001-06-01&rft.volume=39&rft.issue=6&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Aerosols; Metals; Occupational exposure; Respiratory diseases; Pneumonitis; Hypersensitivity; Lung diseases ER - TY - JOUR T1 - Fast neutron radiotherapy for soft tissue and cartilaginous sarcomas at high risk for local recurrence AN - 17890642; 5133844 AB - The practice policy at the University of Washington has been to employ fast neutron radiotherapy for soft tissue sarcoma lesions with prognostic features predictive for poor local control. These include gross residual disease/inoperable disease, recurrent disease, and contaminated surgical margins. Cartilaginous sarcomas have also been included in this high-risk group. This report updates and expands our previously described experience with this approach. Eighty-nine soft tissue sarcoma lesions in 72 patients were treated with neutron radiotherapy in our department between 1984 and 1996. Six patients, each with solitary lesions, were excluded from analysis due to lack of follow-up. Seventy-three percent were treated with fast neutron radiation alone, the rest with a combination of neutrons and photons. Median neutron dose was 18.3 nGy (range 4.8-22). Forty-two patients with solitary lesions were treated with curative intent. Thirty-one patients (including 7 previously treated with neutrons) with 41 lesions were treated with the goal of local palliation. Tumors were predominantly located in the extremity and torso. Thirty of 35 (85%) of curative group patients treated postoperatively had close or positive surgical margins. Thirty-four (82%) lesions treated for palliation were unresectable. Thirty-five patients (53%) were treated at the time of recurrence. Median tumor size at initial presentation was 8.0 cm (range 0.6-29), median treated gross disease size was 5.0 cm (range 1-22), and 46/69 evaluable lesions (67%) were judged to be of intermediate to high histologic grade. Fourteen patients (21%) had chondrosarcomas. Median follow-up was 6 months (range 2-47) and 38 months (range 2-175) for the palliative and curative groups, respectively. Kaplan-Meier estimates were obtained for probability of local relapse-free survival (68%), distant disease-free survival (59%), cause-specific survival (68%), and overall survival (66%) at 4 years for the curatively treated group. For the palliatively treated group, estimated local relapse-free survival at 1 year was 62%. Log-rank analysis of the curative group revealed recurrent disease to be the only risk factor predictive for significantly worse local and distant disease-free survival. Intermediate-/high-grade histology was predictive for inferior overall survival. Effective clinical response was documented for 21/27 (78%) lesions treated palliatively. Ten patients (15%) experienced serious chronic radiation-related complications. All of these patients had clinical situations requiring delivery of high neutron doses and/or large radiotherapy fields. Fast neutron radiotherapy is locally effective for soft tissue and cartilaginous sarcomas having well-recognized high-risk features. Results in the palliative setting appear to be particularly encouraging, with neutrons frequently providing significant symptomatic response for gross disease, with minimal serious chronic sequelae. Fast neutron radiotherapy should be considered in patients at high risk for local recurrence in both the curative and palliative settings. JF - International Journal of Radiation Oncology, Biology, & Physics AU - Schwartz, D L AU - Einck, J AU - Bellon, J AU - Laramore, GE AD - Department of Radiation Oncology, Seattle VA Medical Center/Puget Sound Health Care System [174], 1660 S. Columbian Way, Seattle, WA 98108, USA, david.schwartz2@med.va.gov Y1 - 2001/06/01/ PY - 2001 DA - 2001 Jun 01 SP - 449 EP - 456 VL - 50 IS - 2 SN - 0360-3016, 0360-3016 KW - man KW - cancer patients KW - soft tissues KW - fast neutron radiotherapy KW - Calcium & Calcified Tissue Abstracts; Toxicology Abstracts KW - Neutrons KW - Cartilage diseases KW - Cartilage KW - Sarcoma KW - Radiotherapy KW - Soft tissues KW - X 24210:Radiation & radioactive materials KW - T 20018:Cartilage and cartilage diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17890642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.atitle=Fast+neutron+radiotherapy+for+soft+tissue+and+cartilaginous+sarcomas+at+high+risk+for+local+recurrence&rft.au=Schwartz%2C+D+L%3BEinck%2C+J%3BBellon%2C+J%3BLaramore%2C+GE&rft.aulast=Schwartz&rft.aufirst=D&rft.date=2001-06-01&rft.volume=50&rft.issue=2&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Neutrons; Radiotherapy; Cartilage diseases; Soft tissues; Sarcoma; Cartilage ER - TY - JOUR T1 - Effects of lexical factors on word recognition among normal-hearing and hearing-impaired listeners. AN - 85361941; pmid-11392435 AB - An investigation was conducted to examine the effects of lexical difficulty on spoken word recognition among young normal-hearing and middle-aged and older listeners with hearing loss. Two word lists, based on the lexical characteristics of word frequency and neighborhood density and frequency (Neighborhood Activation Model [NAM]), were developed: (1) lexically "easy" words with high word frequency and a low number and frequency of words phonemically similar to the target word and (2) lexically "hard" words with low word frequency and a high number and frequency of words phonemically similar to the target word. Simple and transformed up-down adaptive strategies were used to estimate performance levels at several locations on the performance-intensity functions of the words. The results verified predictions of the NAM and showed that easy words produced more favorable performance levels than hard words at an equal intelligibility. Although the slopes of the performance-intensity function for the hearing-impaired listeners were less steep than those of normal-hearing listeners, the effects of lexical difficulty on performance were similar for both groups. JF - Journal of the American Academy of Audiology AU - Dirks, D D AU - Takayana, S AU - Moshfegh, A AD - National Center for Rehabilitative Auditory Research, Veterans Administration Medical Center, Portland, OR, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 233 EP - 244 VL - 12 IS - 5 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Aged KW - Aged, 80 and over KW - Auditory Threshold: physiology KW - Female KW - *Hearing Loss, Sensorineural: diagnosis KW - Humans KW - Male KW - Middle Aged KW - Phonetics KW - Random Allocation KW - *Recognition (Psychology) KW - Severity of Illness Index KW - *Speech Perception KW - *Vocabulary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85361941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Effects+of+lexical+factors+on+word+recognition+among+normal-hearing+and+hearing-impaired+listeners.&rft.au=Dirks%2C+D+D%3BTakayana%2C+S%3BMoshfegh%2C+A&rft.aulast=Dirks&rft.aufirst=D&rft.date=2001-05-01&rft.volume=12&rft.issue=5&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - p53 protein overexpression in low grade dysplasia (LGD) in Barrett's esophagus: immunohistochemical marker predictive of progression. AN - 85350560; pmid-11374668 AB - The presence of low grade dysplasia (LGD) within Barrett's esophagus (BE) has a multitude of ramifications. Identification of markers that could risk stratify LGD would be of great clinical benefit. We aimed to prospectively evaluate the prognosis of the immunohistochemical overexpression of p53 protein in BE colocalized to LGD.Consecutive BE patients in whom LGD was found had a repeat esophagogastroduodenoscopy within 8-12 wk per an ongoing prospective study. At each esophagogastroduodenoscopy, a therapeutic scope was used in conjunction with the Seattle Biopsy Protocol. Patients were observed until development of multifocal high grade dysplasia (mHGD), presence of an HGD dysplasia-associated lesion or mass (DALM) lesion, or frank adenocarcinoma. p53 protein overexpression was determined by computerized immunoquantitation using image analysis software on step serial-sectioned specimens of BE segment(s) harboring LGD. Kaplan-Meier survival curves were made on the ability of p53 staining colocalized to areas of LGD to predict progression to mHGD, HGD DALM, or cancer during prospective follow-up.Forty-eight BE patients with LGD were observed for a mean of 41.2+/-22.5 months. During this period, five of 48 patients progressed to mHGD with a focus in which intramucosal cancer could not be excluded (one), mHGD/DALM with one or more foci in which intramucosal cancer could not be excluded (two), cancer (one), or mHGD (one). Twelve had persistent LGD and 31 had regressed to no dysplasia. p53 staining was positive and colocalized to areas of LGD in 4/31 of patients that regressed, 3/12 that persisted, and 3/5 that progressed. Kaplan-Meier curves differed significantly between p53 positive and negative patients for outcome defined as progression of LGD.p53 colocalization with LGD at index LGD diagnosis is a risk factor for progression of LGD. This can potentially be used to risk stratify BE LGD patients in terms of surveillance intervals or enrollment into secondary prevention studies. JF - The American journal of gastroenterology AU - Weston, A P AU - Banerjee, S K AU - Sharma, P AU - Tran, T M AU - Richards, R AU - Cherian, R AD - Cancer Research Unit, Research Division, Veterans Administration Medical Center, Kansas City, Missouri 64128-2226, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 1355 EP - 1362 VL - 96 IS - 5 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - *Barrett Esophagus: metabolism KW - *Barrett Esophagus: pathology KW - Biological Markers KW - Disease Progression KW - Esophageal Neoplasms: metabolism KW - Esophageal Neoplasms: pathology KW - Female KW - Humans KW - Immunohistochemistry KW - Male KW - Middle Aged KW - Prognosis KW - Prospective Studies KW - Risk Factors KW - Survival Analysis KW - *Tumor Suppressor Protein p53: metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85350560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=p53+protein+overexpression+in+low+grade+dysplasia+%28LGD%29+in+Barrett%27s+esophagus%3A+immunohistochemical+marker+predictive+of+progression.&rft.au=Weston%2C+A+P%3BBanerjee%2C+S+K%3BSharma%2C+P%3BTran%2C+T+M%3BRichards%2C+R%3BCherian%2C+R&rft.aulast=Weston&rft.aufirst=A&rft.date=2001-05-01&rft.volume=96&rft.issue=5&rft.spage=1355&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: Am J Gastroenterol. 2001 May;96(5):1321-3[11374661] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Transforming growth factor and neutralizing antibodies in subglottic stenosis. AN - 85350404; pmid-11372920 AB - Transforming growth factor beta 1 (TGF-beta1), which is implicated in the pathogenesis of fibrotic diseases such as interstitial fibrosis, may be associated with subglottic stenosis. To study this hypothesis, we measured TGF-beta1 expression sequentially in 28 rats after posterior cricoid injury, using both standard immunohistochemistry and reverse transcriptase-polymerase chain reaction. In addition, an osmotic pump infused TGF-beta1 in 18 rats, normal saline solution in 9 rats, and neutralizing antibodies in 9 rats. Specimens were stained for fibronectin and procollagen at 1, 7, and 21 days and underwent optical density analysis. In the injured airway, TGF-beta1 expression peaked at 1 day and returned to baseline by 21 days. The TGF-beta1 infusion led to an increase in the expression of extracellular matrix proteins relative to controls. In contrast, neutralizing antibodies led to a decrease in extracellular matrix protein expression. These findings suggest that TGF-beta1 may possibly play a role in the pathogenesis of subglottic stenosis. JF - The Annals of otology, rhinology, and laryngology AU - Dillard, D G AU - Gal, A A AU - Roman-Rodriguez, J AU - White, S AU - Jacobs, I N AD - Department of Otolaryngology, Atlanta Veterans Administration Medical Center and Emory University School of Medicine, Georgia, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 393 EP - 400 VL - 110 IS - 5 Pt 1 SN - 0003-4894, 0003-4894 KW - National Library of Medicine KW - Animals KW - Fibronectins: metabolism KW - Immunohistochemistry KW - *Laryngostenosis: drug therapy KW - *Laryngostenosis: metabolism KW - Male KW - Procollagen: metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Reverse Transcriptase Polymerase Chain Reaction KW - Transforming Growth Factor beta: immunology KW - *Transforming Growth Factor beta: metabolism KW - *Transforming Growth Factor beta: pharmacology KW - Wound Healing: drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85350404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.atitle=Transforming+growth+factor+and+neutralizing+antibodies+in+subglottic+stenosis.&rft.au=Dillard%2C+D+G%3BGal%2C+A+A%3BRoman-Rodriguez%2C+J%3BWhite%2C+S%3BJacobs%2C+I+N&rft.aulast=Dillard&rft.aufirst=D&rft.date=2001-05-01&rft.volume=110&rft.issue=5+Pt+1&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.issn=00034894&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Penicillin-binding protein 5 and expression of ampicillin resistance in Enterococcus faecium. AN - 77057895; 11302814 AB - We report a structural and transcriptional analysis of the pbp5 region of Enterococcus faecium C68. pbp5 exists within a larger operon that includes upstream open reading frames (ORFs) corresponding to previously reported psr (penicillin-binding protein synthesis repressor) and ftsW (whose product is a transmembrane protein that interacts with PBP3 in Escherichia coli septum formation) genes. Hybridization of mRNA from C68, CV133, and four ampicillin-resistant CV133 mutants revealed four distinct transcripts from this region, consisting of (i) E. faecium ftsW (ftsW(Efm)) alone; (ii) psr and pbp5; (iii) pbp5 alone; and (iv) ftsW(Efm), psr, and pbp5. Quantities of the different transcripts varied between strains and did not always correlate with quantities of PBP5 or levels of ampicillin resistance. Since the psr of C68 is presumably nonfunctional due to an insertion of an extra nucleotide in the codon for the 44th amino acid, the region extending from the ftsW(Efm) promoter through the pbp5 gene of C68 was cloned in E. coli to facilitate mutagenesis. The psr ORF was regenerated using site-directed mutagenesis and introduced into E. faecium D344-SRF on conjugative shuttle vector pTCV-lac (pCWR558 [psr ORF interrupted]; pCWR583 [psr ORF intact]). Ampicillin MICs for both D344-SRF(pCWR558) and D344-SRF(pCWR583) were 64 microg/ml. Quantities of pbp5 transcript and protein were similar in strains containing either construct regardless of whether they were grown in the presence or absence of ampicillin, arguing against a role for PSR as a repressor of pbp5 transcription. However, quantities of psr transcript were increased in D344-SRF(pCWR583) compared to D344-SRF(pCWR558), especially after growth in ampicillin; suggesting that PSR acts in some manner to activate its own transcription. JF - Antimicrobial agents and chemotherapy AU - Rice, L B AU - Carias, L L AU - Hutton-Thomas, R AU - Sifaoui, F AU - Gutmann, L AU - Rudin, S D AD - Medical and Research Services, VA Medical Center, Cleveland, Ohio 44106, USA. louis.rice@med.va.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 1480 EP - 1486 VL - 45 IS - 5 SN - 0066-4804, 0066-4804 KW - Bacterial Proteins KW - 0 KW - Carrier Proteins KW - DNA, Bacterial KW - Membrane Proteins KW - Penicillin-Binding Proteins KW - Psr protein, Enterococcus hirae KW - Repressor Proteins KW - FtsW protein, Bacteria KW - 125724-13-2 KW - Peptidyl Transferases KW - EC 2.3.2.12 KW - Hexosyltransferases KW - EC 2.4.1.- KW - Muramoylpentapeptide Carboxypeptidase KW - EC 3.4.17.8 KW - Index Medicus KW - Base Sequence KW - Bacterial Proteins -- genetics KW - Blotting, Northern KW - Genome, Bacterial KW - Molecular Sequence Data KW - Gene Expression KW - Transcription, Genetic KW - DNA, Bacterial -- analysis KW - Repressor Proteins -- genetics KW - Ampicillin Resistance -- genetics KW - Carrier Proteins -- metabolism KW - Enterococcus faecium -- metabolism KW - Enterococcus faecium -- genetics KW - Carrier Proteins -- genetics KW - Muramoylpentapeptide Carboxypeptidase -- genetics KW - Muramoylpentapeptide Carboxypeptidase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77057895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Penicillin-binding+protein+5+and+expression+of+ampicillin+resistance+in+Enterococcus+faecium.&rft.au=Rice%2C+L+B%3BCarias%2C+L+L%3BHutton-Thomas%2C+R%3BSifaoui%2C+F%3BGutmann%2C+L%3BRudin%2C+S+D&rft.aulast=Rice&rft.aufirst=L&rft.date=2001-05-01&rft.volume=45&rft.issue=5&rft.spage=1480&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-02 N1 - Date created - 2001-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4891-6 [10759563] Clin Infect Dis. 1999 Sep;29(3):573-9 [10530450] J Mol Biol. 1983 Jun 5;166(4):557-80 [6345791] J Gen Microbiol. 1983 Mar;129(3):813-22 [6409985] J Bacteriol. 1983 Sep;155(3):1343-50 [6411688] Antimicrob Agents Chemother. 1982 Aug;22(2):295-301 [6927638] J Gen Microbiol. 1985 Aug;131(8):1933-40 [3850924] Antimicrob Agents Chemother. 1985 Nov;28(5):678-83 [3853962] J Bacteriol. 1989 Oct;171(10):5523-30 [2676977] J Bacteriol. 1989 Nov;171(11):6375-8 [2509435] J Mol Biol. 1990 Oct 5;215(3):403-10 [2231712] Antimicrob Agents Chemother. 1992 Jul;36(7):1367-73 [1510429] J Bacteriol. 1993 Apr;175(7):2046-51 [8458847] Antimicrob Agents Chemother. 1994 Sep;38(9):1980-3 [7811006] J Bacteriol. 1996 Aug;178(16):4948-57 [8759860] J Bacteriol. 1996 Sep;178(17):5272-8 [8752348] Antimicrob Agents Chemother. 1996 Feb;40(2):354-7 [8834879] J Bacteriol. 1997 Apr;179(8):2567-72 [9098054] Mol Microbiol. 1997 Jun;24(6):1263-73 [9218774] FEMS Microbiol Lett. 1997 Nov 15;156(2):193-8 [9513264] J Infect Dis. 1998 Jul;178(1):159-63 [9652435] Biotechniques. 1998 Jul;25(1):72-4, 76, 78 [9668979] J Bacteriol. 1998 Sep;180(17):4426-34 [9721279] Clin Infect Dis. 1999 Aug;29(2):259-63 [10476722] DNA Seq. 1998;9(3):149-61 [10520745] J Biol Chem. 2000 Jun 2;275(22):16490-6 [10748168] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanism and suppression of lysostaphin resistance in oxacillin-resistant Staphylococcus aureus. AN - 77054140; 11302806 AB - The potential for the development of resistance in oxacillin-resistant Staphylococcus aureus (ORSA) to lysostaphin, a glycylglycine endopeptidase produced by Staphylococcus simulans biovar staphylolyticus, was examined in vitro and in an in vivo model of infection. Following in vitro exposure of ORSA to subinhibitory concentrations of lysostaphin, lysostaphin-resistant mutants were idenitifed among all isolates examined. Resistance to lysostaphin was associated with a loss of resistance to beta-lactams and a change in the muropeptide interpeptide cross bridge from pentaglycine to a single glycine. Mutations in femA, the gene required for incorporation of the second and third glycines into the cross bridge, were found following PCR amplification and nucleotide sequence analysis. Complementation of lysostaphin-resistant mutants with pBBB31, which encodes femA, restored the phenotype of oxacillin resistance and lysostaphin susceptibility. Addition of beta-lactam antibiotics to lysostaphin in vitro prevented the development of lysostaphin-resistant mutants. In the rabbit model of experimental endocarditis, administration of a low dose of lysostaphin for 3 days led predictably to the appearance of lysostaphin-resistant ORSA mutants in vegetations. Coadministration of nafcillin with lysostaphin prevented the emergence of lysostaphin-resistant mutants and led to a mean reduction in aortic valve vegetation counts of 7.5 log(10) CFU/g compared to those for untreated controls and eliminated the isolation of lysostaphin-resistant mutants from aortic valve vegetations. Treatment with nafcillin and lysostaphin given alone led to mean reductions of 1.35 and 1.65 log(10) CFU/g respectively. In ORSA, resistance to lysostaphin was associated with mutations in femA, but resistance could be suppressed by the coadministration of beta-lactam antibiotics. JF - Antimicrobial agents and chemotherapy AU - Climo, M W AU - Ehlert, K AU - Archer, G L AD - Department of Medicine, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USA. Michael.Climo@med.va.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 1431 EP - 1437 VL - 45 IS - 5 SN - 0066-4804, 0066-4804 KW - Anti-Bacterial Agents KW - 0 KW - Bacterial Proteins KW - FemA protein, Bacteria KW - Penicillins KW - Peptides KW - Lysostaphin KW - EC 3.4.24.75 KW - Oxacillin KW - UH95VD7V76 KW - Index Medicus KW - Penicillins -- pharmacology KW - Drug Resistance, Microbial -- physiology KW - Drug Interactions KW - Bacterial Proteins -- genetics KW - Humans KW - Drug Resistance, Microbial -- genetics KW - Mutation KW - Microbial Sensitivity Tests KW - Oxacillin -- pharmacology KW - Staphylococcus aureus -- genetics KW - Drug Therapy, Combination -- pharmacology KW - Anti-Bacterial Agents -- pharmacology KW - Lysostaphin -- pharmacology KW - Staphylococcus aureus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77054140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Mechanism+and+suppression+of+lysostaphin+resistance+in+oxacillin-resistant+Staphylococcus+aureus.&rft.au=Climo%2C+M+W%3BEhlert%2C+K%3BArcher%2C+G+L&rft.aulast=Climo&rft.aufirst=M&rft.date=2001-05-01&rft.volume=45&rft.issue=5&rft.spage=1431&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-02 N1 - Date created - 2001-04-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 1974 Aug 1;291(5):239-40 [4525537] J Bacteriol. 1964 Sep;88:815-6 [14208531] J Bacteriol. 1991 Jun;173(11):3507-13 [2045371] J Bacteriol. 1993 Mar;175(6):1612-20 [8383661] J Bacteriol. 1993 May;175(9):2779-82 [8478340] J Bacteriol. 2000 May;182(9):2635-8 [10762270] J Bacteriol. 1967 Feb;93(2):520-4 [6020559] Yale J Biol Med. 1967 Feb;39(4):230-44 [4961995] Yale J Biol Med. 1967 Feb;39(4):215-29 [5182857] Antimicrob Agents Chemother (Bethesda). 1967;7:45-53 [5628090] Yale J Biol Med. 1968 Aug;41(1):62-8 [5683827] Yale J Biol Med. 1971 Oct;44(2):206-13 [5123055] Prog Drug Res. 1972;16:309-33 [4265118] J Bacteriol. 1996 Aug;178(16):4975-83 [8759863] J Bacteriol. 1997 Jan;179(1):9-16 [8981974] Microb Drug Resist. 1996 Spring;2(1):29-41 [9158720] J Antimicrob Chemother. 1997 Jul;40(1):59-66 [9249205] J Antimicrob Chemother. 1997 Jul;40(1):135-6 [9249217] FEMS Microbiol Lett. 1997 Aug 15;153(2):261-4 [9271851] J Bacteriol. 1997 Dec;179(23):7573-6 [9393725] J Clin Microbiol. 1998 Apr;36(4):1020-7 [9542929] Antimicrob Agents Chemother. 1998 Jun;42(6):1355-60 [9624475] Curr Pharm Des. 1999 Feb;5(2):45-55 [10066883] FEMS Microbiol Lett. 1999 Feb 15;171(2):97-102 [10077832] Antimicrob Agents Chemother. 1999 Jul;43(7):1747-53 [10390234] Antimicrob Agents Chemother. 1999 Jul;43(7):1754-5 [10390235] Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9351-6 [10430946] Mol Gen Genet. 1989 Oct;219(1-2):263-9 [2559314] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Feverfew extracts and the sesquiterpene lactone parthenolide inhibit intercellular adhesion molecule-1 expression in human synovial fibroblasts. AN - 70989281; 11446741 AB - Previous studies have shown that extracts of the aromatic herb feverfew (Tanacetum parthenium) and one of its bioactive components, parthenolide, have anti-inflammatory properties in vivo and in vitro. We examined both crude feverfew extracts and purified parthenolide for their ability to modulate adhesion molecule expression in human synovial fibroblasts. Pretreatment of synovial fibroblasts with either feverfew extracts or purified parthenolide could inhibit the expression of intercellular adhesion molecule-1 (ICAM-1) induced by the cytokines IL-1 (up to 95% suppression), TNF-alpha (up to 93% suppression), and, less strongly, interferon-gamma (up to 39% suppression). Inhibition of ICAM-1 was dose and time dependent; as little as a 30-min pretreatment with feverfew resulted in inhibition of ICAM-1. The decrease in ICAM-1 expression was accompanied by a decrease in T-cell adhesion to the treated fibroblasts. Other herbal extracts with reported anti-inflammatory effects were similarly tested and did not decrease ICAM-1 expression. The modulation of adhesion molecule expression may be an additional mechanism by which feverfew mediates anti-inflammatory effects. Copyright 2001 Academic Press. JF - Cellular immunology AU - Piela-Smith, T H AU - Liu, X AD - Research Service, Veterans Administration Connecticut Healthcare System, Newington, Connecticut 06111, USA. tsmith@nso2.uchc.edu Y1 - 2001/05/01/ PY - 2001 DA - 2001 May 01 SP - 89 EP - 96 VL - 209 IS - 2 SN - 0008-8749, 0008-8749 KW - Anti-Inflammatory Agents KW - 0 KW - Interleukin-1 KW - Lactones KW - Plant Extracts KW - Sesquiterpenes KW - Tumor Necrosis Factor-alpha KW - Intercellular Adhesion Molecule-1 KW - 126547-89-5 KW - parthenolide KW - 2RDB26I5ZB KW - Interferon-gamma KW - 82115-62-6 KW - Index Medicus KW - Gene Expression -- drug effects KW - Plant Extracts -- pharmacology KW - Fibroblasts -- drug effects KW - Interleukin-1 -- pharmacology KW - Humans KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Interferon-gamma -- pharmacology KW - Fibroblasts -- cytology KW - Cell Adhesion -- drug effects KW - Drug Antagonism KW - Anti-Inflammatory Agents -- pharmacology KW - Tanacetum parthenium KW - Synovial Membrane -- cytology KW - Plants, Medicinal KW - Synovial Membrane -- drug effects KW - Intercellular Adhesion Molecule-1 -- biosynthesis KW - Sesquiterpenes -- pharmacology KW - Lactones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70989281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+immunology&rft.atitle=Feverfew+extracts+and+the+sesquiterpene+lactone+parthenolide+inhibit+intercellular+adhesion+molecule-1+expression+in+human+synovial+fibroblasts.&rft.au=Piela-Smith%2C+T+H%3BLiu%2C+X&rft.aulast=Piela-Smith&rft.aufirst=T&rft.date=2001-05-01&rft.volume=209&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Cellular+immunology&rft.issn=00088749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-16 N1 - Date created - 2001-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Successful remission of late-life drinking problems: a 10-year follow-up. AN - 70941875; 11414342 AB - This study sought to determine (1) the rate and predictors of long-term remission among a sample of untreated late-life problem drinkers and (2) whether successfully remitted older problem drinkers attain levels of functioning and life contexts comparable to those of lifetime nonproblem drinkers at a 10-year follow-up. We compared 140 older baseline problem drinkers who were successful in achieving long-term remission to 184 baseline problem drinkers whose drinking problems did not remit over the course of 10 years and to 339 lifetime nonproblem drinkers, on functioning and life contexts at baseline and at 4- and 10-year follow-ups. Being female, having more recent onset of drinking problems, fewer and less severe drinking problems, friends who approved less of drinking, and drinking less and drinking less frequently at baseline predicted long-term remission. In many regards, long-term remitted problem drinkers attained levels of functioning and life context similar to those of lifetime nonproblem drinkers. However, remitted problem drinkers continued to report more incipient drinking problems, depressive symptoms, health and financial stressors, psychoactive medication use, reliance on avoidance coping strategies and less social support from friends than did lifetime nonproblem drinkers at the 10-year follow-up. About a third (30%) of an untreated sample of late-life problem drinkers succeeded in attaining stable, long-term remission. The functioning and life contexts of untreated remitted problem drinkers improved significantly over time; however, some deficits persisted at follow-up. JF - Journal of studies on alcohol AU - Schutte, K K AU - Byrne, F E AU - Brennan, P L AU - Moos, R H AD - Center for Health Care Evaluation, Department of Veterans Affairs Health Care System, & Stanford University Medical Center, Palo Alto, California 94304, USA. Kathleen.Schutte@med.va.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 322 EP - 334 VL - 62 IS - 3 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Analysis of Variance KW - Prospective Studies KW - Stress, Physiological -- psychology KW - Logistic Models KW - Adaptation, Psychological KW - Humans KW - Chi-Square Distribution KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Alcoholism -- epidemiology KW - Alcoholism -- therapy KW - Remission Induction -- methods KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70941875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Successful+remission+of+late-life+drinking+problems%3A+a+10-year+follow-up.&rft.au=Schutte%2C+K+K%3BByrne%2C+F+E%3BBrennan%2C+P+L%3BMoos%2C+R+H&rft.aulast=Schutte&rft.aufirst=K&rft.date=2001-05-01&rft.volume=62&rft.issue=3&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Destruction of peripheral C-fibers does not alter subsequent vagus nerve stimulation-induced seizure suppression in rats. AN - 70879511; 11380564 AB - Early animal studies of the therapeutic mechanisms of vagus nerve stimulation (VNS) suggested that seizure suppression requires maximal activation of small, unmyelinated vagal C fibers. However, effective therapeutic stimulation parameters appear to be subthreshold for these fibers in humans, and there are no clinical reports of the autonomic side effects that would be expected if these fibers were maximally activated. We report here that selective destruction of C fibers with capsaicin does not affect VNS-induced seizure suppression in rats. Rats were pretreated with capsaicin or vehicle in three injections over a 2-day period. A cuff electrode was later implanted on the left cervical vagus nerve. Two days after surgery, VNS was given to half of the capsaicin- and vehicle-treated rats. The remaining rats were connected to the stimulator but did not receive VNS. Thirty seconds after VNS onset, seizures were induced by pentylenetetrazol (PTZ), and seizure severity was measured. Two days later, the reciprocal VNS treatment was given, and PTZ-induced seizure severity was again measured. VNS effectively reduced seizure severity in both capsaicin- and vehicle-treated rats as compared with their non-VNS baselines. These results indicate that activation of vagal C fibers is not necessary for VNS-induced seizure suppression. JF - Epilepsia AU - Krahl, S E AU - Senanayake, S S AU - Handforth, A AD - Neurology Service, VA Greater Los Angeles Healthcare System, California 90073, USA. scott.krahl@med.va.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 586 EP - 589 VL - 42 IS - 5 SN - 0013-9580, 0013-9580 KW - Capsaicin KW - S07O44R1ZM KW - Pentylenetetrazole KW - WM5Z385K7T KW - Index Medicus KW - Severity of Illness Index KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Humans KW - Nerve Degeneration -- chemically induced KW - Animals, Newborn -- physiology KW - Capsaicin -- pharmacology KW - Seizures -- chemically induced KW - Nerve Fibers -- physiology KW - Nerve Fibers -- drug effects KW - Vagus Nerve -- physiology KW - Seizures -- diagnosis KW - Seizures -- prevention & control KW - Electric Stimulation Therapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70879511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsia&rft.atitle=Destruction+of+peripheral+C-fibers+does+not+alter+subsequent+vagus+nerve+stimulation-induced+seizure+suppression+in+rats.&rft.au=Krahl%2C+S+E%3BSenanayake%2C+S+S%3BHandforth%2C+A&rft.aulast=Krahl&rft.aufirst=S&rft.date=2001-05-01&rft.volume=42&rft.issue=5&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=Epilepsia&rft.issn=00139580&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-28 N1 - Date created - 2001-05-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oxidized LDL differentially regulates MMP-1 and TIMP-1 expression in vascular endothelial cells. AN - 70858880; 11369004 AB - We have reported recently that oxidized low-density lipoprotein (oxLDL) stimulates matrix metalloproteinase-1 (MMP-1) expression in human vascular endothelial cells. The present study was conducted to examine the effect of oxLDL on expression of Tissue inhibitor of metalloproteinase-1 (TIMP-1), an endogenous inhibitor of MMPs, in human vascular endothelial cells. Our enzyme-linked immunosorbent assay and Northern blot analysis showed that oxLDL inhibited TIMP-1 secretion and expression by human umbilical vein endothelial cells. In contrast, PMA stimulated TIMP-1 expression and secretion. Both oxLDL and PMA increased MMP-1 expression and secretion significantly as previously reported. Inhibition by oxLDL of TIMP-1 expression was also observed in human aortic endothelial cells. Collagenase activity as detected by an enzymatic activity assay demonstrated, as expected, an increase in collagenase activity in the culture medium from oxLDL-treated cells as compared with that from untreated cells. The presented data indicates that oxLDL differentially regulates TIMP-1 and MMP-1 expression, whereas PMA coordinately regulates TIMP-1 and MMP-1 in vascular endothelial cells. The lack of coordination in the secretion of MMP-1 and TIMP-1 induced by oxLDL leads to an increased collagen-degrading activity that may contribute to destabilization of atherosclerotic plaques. JF - Atherosclerosis AU - Huang, Y AU - Song, L AU - Wu, S AU - Fan, F AU - Lopes-Virella, M F AD - Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC 29401, USA. huangyan@musc.edu Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 119 EP - 125 VL - 156 IS - 1 SN - 0021-9150, 0021-9150 KW - Culture Media KW - 0 KW - Lipoproteins, LDL KW - Tissue Inhibitor of Metalloproteinase-1 KW - oxidized low density lipoprotein KW - Collagenases KW - EC 3.4.24.- KW - Matrix Metalloproteinase 1 KW - EC 3.4.24.7 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Umbilical Veins -- metabolism KW - Cells, Cultured KW - Humans KW - Collagenases -- analysis KW - Umbilical Veins -- cytology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Umbilical Veins -- drug effects KW - Culture Media -- chemistry KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Matrix Metalloproteinase 1 -- metabolism KW - Endothelium, Vascular -- cytology KW - Tissue Inhibitor of Metalloproteinase-1 -- metabolism KW - Lipoproteins, LDL -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70858880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atherosclerosis&rft.atitle=Oxidized+LDL+differentially+regulates+MMP-1+and+TIMP-1+expression+in+vascular+endothelial+cells.&rft.au=Huang%2C+Y%3BSong%2C+L%3BWu%2C+S%3BFan%2C+F%3BLopes-Virella%2C+M+F&rft.aulast=Huang&rft.aufirst=Y&rft.date=2001-05-01&rft.volume=156&rft.issue=1&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Atherosclerosis&rft.issn=00219150&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-23 N1 - Date created - 2001-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of Persian Gulf veterans with symptoms of peripheral neuropathy. AN - 70854814; 11370211 AB - Persian Gulf syndrome is a set of symptoms that do not fit into well-understood diagnostic categories. Among these symptoms, there are some that could suggest a generalized neuropathic process. Correlate neurological symptoms with objective electrodiagnostic findings. A randomized sample of 176 Persian Gulf veterans (PGV) evaluated at the San Juan Veterans Administration Medical Center was obtained. The subjects completed a questionnaire, and those who met the inclusion criteria underwent electrodiagnostic evaluation. Of the 176 PGV selected, 162 completed the questionnaire. The next step was to perform electrodiagnostic studies on those who described symptoms suggesting peripheral neuropathy and met the inclusion criteria. Twelve individuals met the inclusion criteria for electro-diagnostic studies. All studies were normal except that two subjects were found to have bilateral carpal tunnel syndrome. Although this is a relatively small sample of PGV, the findings are in accordance with other studies in which no definite generalized neuropathic pattern has been described. JF - Military medicine AU - Rivera-Zayas, J AU - Arroyo, M AU - Mejias, E AD - Department of Physical Medicine and Rehabilitation, San Juan Veterans Administration Medical Center, 672/151, 10 Casia Street, San Juan, Puerto Rico 00921-3201. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 449 EP - 451 VL - 166 IS - 5 SN - 0026-4075, 0026-4075 KW - Index Medicus KW - Warfare KW - Polyneuropathies -- diagnosis KW - Humans KW - Adult KW - Neurologic Examination KW - Middle Aged KW - Neuropsychological Tests KW - United States -- epidemiology KW - Male KW - Female KW - Polyneuropathies -- classification KW - Veterans KW - Peripheral Nervous System Diseases -- epidemiology KW - Peripheral Nervous System Diseases -- etiology KW - Persian Gulf Syndrome -- epidemiology KW - Persian Gulf Syndrome -- diagnosis KW - Persian Gulf Syndrome -- physiopathology KW - Peripheral Nervous System Diseases -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70854814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+medicine&rft.atitle=Evaluation+of+Persian+Gulf+veterans+with+symptoms+of+peripheral+neuropathy.&rft.au=Rivera-Zayas%2C+J%3BArroyo%2C+M%3BMejias%2C+E&rft.aulast=Rivera-Zayas&rft.aufirst=J&rft.date=2001-05-01&rft.volume=166&rft.issue=5&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=Military+medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-21 N1 - Date created - 2001-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Major depressive disorder. Psychopathology, medical management and dental implications. AN - 70841091; 11367967 AB - Major depressive disorder, or MDD, is a psychiatric illness in which mood, thoughts and behavioral patterns are impaired for long periods. The illness distresses the person and impairs his or her social functioning and quality of life. MDD is characterized by marked sadness or a loss of interest or pleasure in daily activities, and is accompanied by weight change, sleep disturbance, fatigue, difficulty concentrating, physical impairment and a high suicide rate. In 2000, the World Health Organization, or WHO, identified MDD as the fourth ranked cause of disability and premature death in the world. WHO projected that by 2020, MDD would rise in disease burden to be second only to ischemic heart disease. The disorder is common in the United States, with a lifetime prevalence rate of 17 percent and a recurrence rate of more than 50 percent. MDD may be associated with extensive dental disease, and people may seek dental treatment before becoming aware of their psychiatric illness. MDD frequently is associated with a disinterest in performing appropriate oral hygiene techniques, a cariogenic diet, diminished salivary flow, rampant dental caries, advanced periodontal disease and oral dysesthesias. Many medications used to treat the disease magnify the xerostomia and increase the incidence of dental disease. Appropriate dental management requires a vigorous dental education program, the use of saliva substitutes and anticaries agents containing fluoride, and special precautions when prescribing or administering analgesics and local anesthetics. Dentists cognizant of these signs and symptoms have an opportunity to recognize patients with occult MDD. After confirmation of the diagnosis and institution of treatment by a mental health practitioner, dentists usually can provide a full range of services that may enhance patients' self-esteem and contribute to the psychotherapeutic aspect of management. JF - Journal of the American Dental Association (1939) AU - Friedlander, A H AU - Mahler, M E AD - Veterans Affairs Greater Los Angeles Healthcare System (14), 11301 Wilshire Blvd., Los Angeles, Calif. 90073, USA. arthur.friedlander@med.va.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 629 EP - 638 VL - 132 IS - 5 SN - 0002-8177, 0002-8177 KW - Analgesics KW - 0 KW - Antidepressive Agents KW - Cariostatic Agents KW - Saliva, Artificial KW - Fluorides KW - Q80VPU408O KW - Dentistry KW - Index Medicus KW - Humans KW - Interpersonal Relations KW - Suicide KW - Aged KW - Quality of Life KW - Antidepressive Agents -- adverse effects KW - Fluorides -- therapeutic use KW - Dental Caries -- etiology KW - Xerostomia -- chemically induced KW - Saliva -- secretion KW - Sensation Disorders -- etiology KW - Diet, Cariogenic KW - Affect KW - Male KW - Saliva, Artificial -- therapeutic use KW - Cariostatic Agents -- therapeutic use KW - Periodontal Diseases -- etiology KW - Recurrence KW - Sleep Wake Disorders -- physiopathology KW - Fatigue -- physiopathology KW - Patient Education as Topic KW - Oral Hygiene KW - Antidepressive Agents -- therapeutic use KW - Middle Aged KW - Analgesics -- therapeutic use KW - Female KW - Prevalence KW - Depressive Disorder -- psychology KW - Depressive Disorder -- physiopathology KW - Depressive Disorder -- drug therapy KW - Dental Care for Chronically Ill UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70841091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Major+depressive+disorder.+Psychopathology%2C+medical+management+and+dental+implications.&rft.au=Friedlander%2C+A+H%3BMahler%2C+M+E&rft.aulast=Friedlander&rft.aufirst=A&rft.date=2001-05-01&rft.volume=132&rft.issue=5&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-26 N1 - Date created - 2001-05-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Am Dent Assoc 2001 Jun;132(6):736 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Asbestos causes apoptosis in alveolar epithelial cells: role of iron-induced free radicals. AN - 70821746; 11329530 AB - Asbestos causes asbestosis and malignancies by mechanisms that are not fully understood. Alveolar epithelial cell (AEC) injury by iron-induced reactive oxygen species (ROS) is one important mechanism. To determine whether asbestos causes apoptosis in AECs, we exposed WI-26 (human type I-like cells), A549 (human type II-like cells), and rat alveolar type II cells to amosite asbestos and assessed apoptosis by terminal deoxynucleotidyl transferase-mediated deoxyuridine-5'-triphosphate-biotin nick end labeling (TUNEL) staining, nuclear morphology, annexin V staining, DNA nucleosome formation, and caspase 3 activation. In contrast to control medium and TiO2, amosite asbestos and H2O2 each caused AEC apoptosis. A role for iron-catalyzed ROS was suggested by the finding that asbestos-induced AEC apoptosis and caspase 3 activation were each attenuated by either an iron chelator (phytic acid and deferoxamine) or a.OH scavenger (dimethyl-thiourea, salicylate, and sodium benzoate) but not by iron-loaded phytic acid. To determine whether asbestos causes apoptosis in vivo, rats received a single intratracheal instillation of amosite (5 mg) or normal saline solution, and apoptosis in epithelial cells in the bronchoalveolar duct regions was assessed by TUNEL staining. One week after exposure, amosite asbestos caused a 3-fold increase in the percentage of apoptotic cells in the bronchoalveolar duct regions as compared with control (control, 2.1% +/- 0.35%; asbestos, 7.61% +/- 0.15%; n = 3). However, by 4 weeks the number of apoptotic cells was similar to control. We conclude that asbestos-induced pulmonary toxicity may partly be caused by apoptosis in the lung epithelium that is mediated by iron-catalyzed ROS and caspase 3 activation. JF - The Journal of laboratory and clinical medicine AU - Aljandali, A AU - Pollack, H AU - Yeldandi, A AU - Li, Y AU - Weitzman, S A AU - Kamp, D W AD - Department of Medicine, Divisions of Pulmonary and Critical Care Medicine and Hematology-Oncology, Northwestern University Medical School and Veterans Administration Chicago Health Care System, Lakeside Division, IL, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 330 EP - 339 VL - 137 IS - 5 SN - 0022-2143, 0022-2143 KW - Free Radical Scavengers KW - 0 KW - Iron Chelating Agents KW - Reactive Oxygen Species KW - Asbestos, Amosite KW - 12172-73-5 KW - Hydroxyl Radical KW - 3352-57-6 KW - Phytic Acid KW - 7IGF0S7R8I KW - Hydrogen Peroxide KW - BBX060AN9V KW - Iron KW - E1UOL152H7 KW - CASP3 protein, human KW - EC 3.4.22.- KW - Casp3 protein, rat KW - Caspase 3 KW - Caspases KW - Sodium Benzoate KW - OJ245FE5EU KW - Abridged Index Medicus KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Cell Count KW - Dose-Response Relationship, Drug KW - Hydroxyl Radical -- metabolism KW - Humans KW - Intubation, Intratracheal KW - Sodium Benzoate -- pharmacology KW - Iron Chelating Agents -- pharmacology KW - Iron -- metabolism KW - Caspases -- metabolism KW - Rats KW - Hydrogen Peroxide -- toxicity KW - In Situ Nick-End Labeling KW - Rats, Sprague-Dawley KW - Cells, Cultured KW - Instillation, Drug KW - Phytic Acid -- pharmacology KW - Free Radical Scavengers -- pharmacology KW - Epithelial Cells -- metabolism KW - Asbestos, Amosite -- administration & dosage KW - Epithelial Cells -- cytology KW - Epithelial Cells -- drug effects KW - Apoptosis KW - Pulmonary Alveoli -- metabolism KW - Bronchi -- cytology KW - Asbestos, Amosite -- toxicity KW - Pulmonary Alveoli -- drug effects KW - Pulmonary Alveoli -- cytology KW - Bronchi -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70821746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+laboratory+and+clinical+medicine&rft.atitle=Asbestos+causes+apoptosis+in+alveolar+epithelial+cells%3A+role+of+iron-induced+free+radicals.&rft.au=Aljandali%2C+A%3BPollack%2C+H%3BYeldandi%2C+A%3BLi%2C+Y%3BWeitzman%2C+S+A%3BKamp%2C+D+W&rft.aulast=Aljandali&rft.aufirst=A&rft.date=2001-05-01&rft.volume=137&rft.issue=5&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+laboratory+and+clinical+medicine&rft.issn=00222143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-05-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Lab Clin Med. 2001 May;137(5):314-5 [11329527] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vascular insulin/insulin-like growth factor-1 resistance in female obese Zucker rats. AN - 70816566; 11319726 AB - Because insulin resistance/diabetes may cause inordinate vascular complications in females, we have investigated the effects of insulin and insulin-like growth factor (IGF-1) on vascular reactivity in 12-week-old female Zucker obese (Ob) rats, a rodent model of insulin resistance and its lean (Ln) age-matched counterpart. Endothelium intact aortic rings from Ob animals and their Ln littermates (12 weeks of age) were subjected to contractile concentration responses to phenylephrine (PE) followed by relaxation to isoproterenol (Iso), with and without preincubation for 2 hours with cholera toxin (CTX; 1 microg/mL) or pertussis toxin (PTX; 2 microg/mL) and before and after incubation with either insulin or IGF-1 (100 nmol/L) for 1 hour. Systolic blood pressure was higher (138 +/- 3 v. 109 +/- 4 mm Hg; P <.0001) in the 12-week-old Ob rats. Contractile responses to PE were similar in both groups; however, both insulin and IGF-1 induced a paradoxical increase (P <.001) in contraction in Ob vasculature (929 +/- 92 v. 679 +/- 25 mg, respectively). CTX alone decreased contraction in the Ob (P <.02) and PTX in the Ln (P <.02), but there were no interactions between either IGF-1 or insulin and the toxins. Marked impairment of relaxation to Iso was seen in aortic rings of these female Ob rats (ED(50) = 2.6 micromol/L v. 418 nmol/L, P =.0002), an effect exacerbated by preincubation with either insulin or IGF-1 (P =.0001). Again, no role for G-proteins could be demonstrated. Insulin-dependent glucose uptake was severely impaired (P <.05) in aortic segments of the Ob insulin-resistant rats. Insulin receptor binding, tyrosine kinase activity (TKA), and abundance of several G-protein alpha subunits (inhibitory and stimulatory) in solubilized arterial membrane preparations (assessed by Western blot) were comparable in the 2 groups. These results indicate that resistance to the vascular actions of insulin/IGF-1 in female Ob rats is a postreceptor event that parallels glucose uptake resistance and is independent of G-proteins. Copyright 2001 by W.B. Saunders Company. JF - Metabolism: clinical and experimental AU - Walsh, M F AU - Ali, S S AU - Sowers, J R AD - Division of Endocrinology, Diabetes, and Hypertension, SUNY Health Science Center at Brooklyn, and Veterans Administration Medical Center (VAMC) Brooklyn, Brooklyn, NY, USA. Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 607 EP - 612 VL - 50 IS - 5 SN - 0026-0495, 0026-0495 KW - Virulence Factors, Bordetella KW - 0 KW - Tritium KW - 10028-17-8 KW - Phenylephrine KW - 1WS297W6MV KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Cholera Toxin KW - 9012-63-9 KW - Deoxyglucose KW - 9G2MP84A8W KW - Pertussis Toxin KW - EC 2.4.2.31 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Receptor, Insulin KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Isoproterenol KW - L628TT009W KW - Index Medicus KW - Animals KW - Aorta KW - Cholera Toxin -- pharmacology KW - GTP-Binding Proteins -- physiology KW - Muscle Relaxation -- drug effects KW - Protein-Tyrosine Kinases -- metabolism KW - Rats, Zucker KW - Endothelium, Vascular KW - Isoproterenol -- pharmacology KW - Rats KW - Virulence Factors, Bordetella -- pharmacology KW - Muscle Contraction -- drug effects KW - Female KW - Receptor, Insulin -- metabolism KW - Deoxyglucose -- metabolism KW - Phenylephrine -- pharmacology KW - Muscle, Smooth, Vascular -- physiopathology KW - Muscle, Smooth, Vascular -- drug effects KW - Drug Resistance KW - Insulin Resistance KW - Obesity -- physiopathology KW - Insulin-Like Growth Factor I -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70816566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolism%3A+clinical+and+experimental&rft.atitle=Vascular+insulin%2Finsulin-like+growth+factor-1+resistance+in+female+obese+Zucker+rats.&rft.au=Walsh%2C+M+F%3BAli%2C+S+S%3BSowers%2C+J+R&rft.aulast=Walsh&rft.aufirst=M&rft.date=2001-05-01&rft.volume=50&rft.issue=5&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Metabolism%3A+clinical+and+experimental&rft.issn=00260495&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A meta-analysis comparing buprenorphine to methadone for treatment of opiate dependence. AN - 70798058; 11331027 AB - The unique pharmacological properties of buprenorphine may make it a useful maintenance therapy for opiate addiction. This meta-analysis considers the effectiveness of buprenorphine relative to methadone. A systematic literature search identified five randomized clinical trials comparing buprenorphine to methadone. Data from these trials were obtained. Retention in treatment was analyzed with a Cox proportional hazards regression. Urinalyses for opiates were studied with analysis of variance and a common method of handling missing values. A meta-analysis was used to combine these results. Subjects who received 8-12 mg/day buprenorphine had 1.26 times the relative risk of discontinuing treatment (95% confidence interval 1.01-1.57) and 8.3% more positive urinalyses (95% confidence interval 2.7-14%) than subjects receiving 50-80 mg/day methadone. Buprenophrine was more effective than 20-35 mg/day methadone. There was substantial variation in outcomes in the different trials. The variation between trials may be due to differences in dose levels, patient exclusion criteria and provision of psychosocial treatment. The difference in the effectiveness of buprenorphine and methadone may be statistically significant, but the differences are small compared to the wide variance in outcomes achieved in different methadone treatment programs. Further research is needed to determine if buprenorphine treatment is more effective than methadone in particular settings or in particular subgroups of patients. JF - Addiction (Abingdon, England) AU - Barnett, P G AU - Rodgers, J H AU - Bloch, D A AD - Cooperative Studies Program and Health Economics Resource Center, VA Palo Alto Health Care System, US Department of Veterans Affairs, Menlo Park, CA 94025, USA. paul.barnett@med.va.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 683 EP - 690 VL - 96 IS - 5 SN - 0965-2140, 0965-2140 KW - Narcotics KW - 0 KW - Buprenorphine KW - 40D3SCR4GZ KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Analysis of Variance KW - Patient Compliance KW - Humans KW - Treatment Outcome KW - Patient Dropouts -- statistics & numerical data KW - Proportional Hazards Models KW - Methadone -- therapeutic use KW - Buprenorphine -- therapeutic use KW - Narcotics -- urine KW - Narcotics -- therapeutic use KW - Opioid-Related Disorders -- rehabilitation KW - Opioid-Related Disorders -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70798058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=A+meta-analysis+comparing+buprenorphine+to+methadone+for+treatment+of+opiate+dependence.&rft.au=Barnett%2C+P+G%3BRodgers%2C+J+H%3BBloch%2C+D+A&rft.aulast=Barnett&rft.aufirst=P&rft.date=2001-05-01&rft.volume=96&rft.issue=5&rft.spage=683&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-14 N1 - Date created - 2001-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antibiotic Susceptibilities of Genetically Characterized Streptococcus milleri Group Strains AN - 17882174; 5117520 AB - Previous studies of the antibiotic susceptibility of Streptococcus milleri group organisms have distinguished among species by using phenotypic techniques. Using 44 isolates that were speciated by 16S rRNA gene sequencing, we studied the MICs and minimum bactericidal concentrations of penicillin, ampicillin, ceftriaxone, and clindamycin for Streptococcus intermedius, Streptococcus constellatus, and Streptococcus anginosus. None of the organisms was resistant to beta-lactam antibiotics, although a few isolates were intermediately resistant; one strain of S. anginosus was tolerant to ampicillin, and another was tolerant to ceftriaxone. Six isolates were resistant to clindamycin, with representation from each of the three species. Relatively small differences in antibiotic susceptibilities among species of the S. milleri group show that speciation is unlikely to be important in selecting an antibiotic to treat infection caused by one of these isolates. JF - Antimicrobial Agents & Chemotherapy AU - Tracy, M AU - Wanahita, A AU - Shuhatovich, Y AU - Goldsmith, E A AU - Clarridge, JE III AU - Musher, D M AD - Infectious Disease Section, Veterans Affairs Medical Center, Houston, TX 77030, USA, daniel.musher@med.va.gov Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 1511 EP - 1514 VL - 45 IS - 5 SN - 0066-4804, 0066-4804 KW - isolates KW - rRNA 16S KW - Microbiology Abstracts B: Bacteriology KW - Speciation KW - Antibiotic sensitivity testing KW - Streptococcus milleri KW - ^b-Lactam antibiotics KW - J 02783:Antibiotics: General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17882174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Antibiotic+Susceptibilities+of+Genetically+Characterized+Streptococcus+milleri+Group+Strains&rft.au=Tracy%2C+M%3BWanahita%2C+A%3BShuhatovich%2C+Y%3BGoldsmith%2C+E+A%3BClarridge%2C+JE+III%3BMusher%2C+D+M&rft.aulast=Tracy&rft.aufirst=M&rft.date=2001-05-01&rft.volume=45&rft.issue=5&rft.spage=1511&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus milleri; Antibiotic sensitivity testing; Speciation; ^b-Lactam antibiotics ER - TY - JOUR T1 - Spa Contributes to the Virulence of Type 18 Group A Streptococci AN - 17854698; 4875023 AB - Streptococcal protective antigen (Spa) is a newly described surface protein of group A streptococci that was recently shown to evoke protective antibodies (J. B. Dale, E. Y. Chiang, S. Liu, H. S. Courtney, and D. L. Hasty, J. Clin. Investig. 103:1261-1268, 1999). In this study, we have determined the complete sequence of the spa gene from type 18 streptococci. Purified, recombinant Spa protein evoked antibodies that were bactericidal against type 18 streptococci, confirming the presence of protective epitopes. Sera from patients with acute rheumatic fever contained antibodies against recombinant Spa, indicating that the Spa protein is expressed in vivo and is immunogenic in humans. To determine the role of Spa in the virulence of group A streptococci, we created a series of insertional mutants that were (i) Spa negative and M18 positive, (ii) Spa positive and M18 negative, and (iii) Spa negative and M18 negative. The mutants and the parent M18 strain (18-282) were used in assays to determine resistance to phagocytosis, growth in human blood, and mouse virulence. The results show that Spa is a virulence determinant of group A streptococci and that expression of both Spa and M18 is required for optimal virulence of type 18 streptococci. JF - Infection and Immunity AU - McLellan, DGJ AU - Chiang, E Y AU - Courtney, H S AU - Hasty, D L AU - Wei, S C AU - Hu, M C AU - Walls, MA AU - Bloom, J J AU - Dale, J B AD - VA Medical Center (11A), 1030 Jefferson Ave., Memphis, TN 38104, JAMES.DALE@MED.VA.GOV Y1 - 2001/05// PY - 2001 DA - May 2001 SP - 2943 EP - 2949 VL - 69 IS - 5 SN - 0019-9567, 0019-9567 KW - nucleotide sequence KW - streptococci KW - Streptococcal protective antigen KW - psa gene KW - rheumatic fever KW - Microbiology Abstracts B: Bacteriology KW - Virulence KW - Streptococcus KW - J 02832:Antigenic properties and virulence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17854698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Spa+Contributes+to+the+Virulence+of+Type+18+Group+A+Streptococci&rft.au=McLellan%2C+DGJ%3BChiang%2C+E+Y%3BCourtney%2C+H+S%3BHasty%2C+D+L%3BWei%2C+S+C%3BHu%2C+M+C%3BWalls%2C+MA%3BBloom%2C+J+J%3BDale%2C+J+B&rft.aulast=McLellan&rft.aufirst=DGJ&rft.date=2001-05-01&rft.volume=69&rft.issue=5&rft.spage=2943&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.69.5.2943-2949.2001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus; Virulence DO - http://dx.doi.org/10.1128/IAI.69.5.2943-2949.2001 ER - TY - JOUR T1 - An update on hypercoagulable disorders. AN - 70798892; 11322838 AB - Venous thrombosis is a cause of considerable morbidity and is often responsible for chronic venous disorders that frequently lead to visits to dermatologists and others involved in wound healing. Over the past several years, many new causes of thrombophilia have been identified and have dramatically altered the approach to patients presenting with thrombosis. Newly described abnormalities associated with thrombophilia include the syndrome of activated protein C resistance, the prothrombin 20210A mutation, hyperhomocysteinemia, and elevated levels of coagulation factors VIII and XI. Clinicians can now frequently determine causes of thromboses that have previously been deemed idiopathic. JF - Archives of internal medicine AU - Federman, D G AU - Kirsner, R S AD - VA Connecticut HCS (11ACSL), 950 Campbell Ave, West Haven, CT 06516, USA. Federman.Daniel_G+@west-haven.va.gov Y1 - 2001/04/23/ PY - 2001 DA - 2001 Apr 23 SP - 1051 EP - 1056 VL - 161 IS - 8 SN - 0003-9926, 0003-9926 KW - Anticoagulants KW - 0 KW - Contraceptives, Oral KW - factor V Leiden KW - Warfarin KW - 5Q7ZVV76EI KW - Factor V KW - 9001-24-5 KW - Prothrombin KW - 9001-26-7 KW - Abridged Index Medicus KW - Index Medicus KW - Contraceptives, Oral -- adverse effects KW - Anticoagulants -- therapeutic use KW - Activated Protein C Resistance -- etiology KW - Humans KW - Activated Protein C Resistance -- blood KW - Pregnancy Complications, Cardiovascular -- etiology KW - Warfarin -- therapeutic use KW - Prothrombin -- genetics KW - Recurrence KW - Pregnancy KW - Factor V -- metabolism KW - Hyperhomocysteinemia -- complications KW - Risk Factors KW - Mutation KW - Female KW - Blood Coagulation Disorders -- etiology KW - Blood Coagulation Disorders -- drug therapy KW - Blood Coagulation Disorders -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70798892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=An+update+on+hypercoagulable+disorders.&rft.au=Federman%2C+D+G%3BKirsner%2C+R+S&rft.aulast=Federman&rft.aufirst=D&rft.date=2001-04-23&rft.volume=161&rft.issue=8&rft.spage=1051&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-10 N1 - Date created - 2001-04-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 2002 Mar 11;162(5):613-4 [11871942] Arch Intern Med. 2002 Mar 11;162(5):613; author reply 614 [11871941] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Serum cholesterol, suicidal behavior and impulsivity in cocaine-dependent patients. AN - 77066126; 11311927 AB - Relationships between serum cholesterol and suicidal behavior have been reported. As suicidal behavior is common in cocaine dependence, we looked for a relationship with serum cholesterol. To do this, we compared 57 cocaine-dependent patients who had attempted suicide with 111 cocaine-dependent patients who had never attempted suicide for their admission total serum cholesterol levels. We found that there were no significant differences between cocaine-dependent patients who had or had not attempted suicide in their total serum cholesterol levels. Also, there were no significant correlations between total serum cholesterol levels and scores on the Barratt Impulsivity Scale. Thus, admission total serum cholesterol does not appear to be clinically useful in the assessment of suicidal behavior in cocaine-dependent patients. JF - Psychiatry research AU - Roy, A AU - Gonzalez, B AU - Marcus, A AU - Berman, J AD - Psychiatry Service (116A), Department of Veterans Affairs, New Jersey Healthcare System, 385 Tremont Avenue, East Orange, NJ 07018, USA. Deborah.Strickland@med.va.gov Y1 - 2001/04/15/ PY - 2001 DA - 2001 Apr 15 SP - 243 EP - 247 VL - 101 IS - 3 SN - 0165-1781, 0165-1781 KW - Cholesterol KW - 97C5T2UQ7J KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Cholesterol -- blood KW - Suicide, Attempted -- statistics & numerical data KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- blood KW - Impulsive Behavior -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77066126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Serum+cholesterol%2C+suicidal+behavior+and+impulsivity+in+cocaine-dependent+patients.&rft.au=Roy%2C+A%3BGonzalez%2C+B%3BMarcus%2C+A%3BBerman%2C+J&rft.aulast=Roy&rft.aufirst=A&rft.date=2001-04-15&rft.volume=101&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-05 N1 - Date created - 2001-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Verbal Learning and Memory Deficits in Traumatic Brain Injury: Encoding, Consolidation, and Retrieval AN - 85542026; 200113303 AB - The present study examined the nature of verbal memory deficits in individuals with traumatic brain injury compared to healthy controls. The study was designed to control for methodological shortcomings of previous related research. Three groups of participants were used: (1) a head injured sample with moderate to severe traumatic brain injuries (N = 55), (2) a control sample matched on age & initial performance on CVLT Trial 5 & Sum of Trials 1 to 5 (N = 55), & (3) a control sample matched on age, education, & race, but not on initial CVLT learning performance (N = 55). Current findings indicate that: (A) rate of learning was comparable across groups, consistent with no encoding differences, (B) traumatic brain injury patients have a significantly more rapid rate of forgetting of new information than either acquisition-matched or demographic-matched controls, consistent with consolidation problems in traumatic brain injury, (C) traumatic brain injury patients have less proactive interference than demographic-matched control participants, consistent with a consolidation problem in the traumatic brain injury group, (D) traumatic brain injury patients & acquisition-matched controls have comparably low rates of proactive interference, consistent with impaired acquisition in both of these groups, & (E) traumatic brain injury patients & controls do not differ in the benefit experienced from semantic or recognition retrieval cues, consistent with no differences in retrieval processes. These data support an impaired consolidation hypothesis, rather than encoding or retrieval deficits, as the primary deficit underlying memory impairment in traumatic brain injury. 2 Tables, 2 Figures, 35 References. Adapted from the source document JF - Journal of Clinical and Experimental Neuropsychology AU - Vanderploeg, Rodney D AU - Crowell, Timothy A AU - Curtiss, Glenn AD - Psychology Service, James A. Haley Veterans Hospital, Tampa, FL Rodney.Vanderploeg@med.va.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 185 EP - 195 VL - 23 IS - 2 SN - 1380-3395, 1380-3395 KW - Brain Damage (09400) KW - Verbal Learning (93750) KW - Memory Disorders (52800) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85542026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+and+Experimental+Neuropsychology&rft.atitle=Verbal+Learning+and+Memory+Deficits+in+Traumatic+Brain+Injury%3A+Encoding%2C+Consolidation%2C+and+Retrieval&rft.au=Vanderploeg%2C+Rodney+D%3BCrowell%2C+Timothy+A%3BCurtiss%2C+Glenn&rft.aulast=Vanderploeg&rft.aufirst=Rodney&rft.date=2001-04-01&rft.volume=23&rft.issue=2&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+and+Experimental+Neuropsychology&rft.issn=13803395&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCENE8 N1 - SubjectsTermNotLitGenreText - Verbal Learning (93750); Memory Disorders (52800); Brain Damage (09400) ER - TY - JOUR T1 - Combined androgen blockade with nonsteroidal antiandrogens for advanced prostate cancer: a systematic review. AN - 77063879; 11306391 AB - Combined androgen blockade with medical or surgical castration plus a nonsteroidal antiandrogen for metastatic prostate cancer has been the subject of 20 randomized trials. The findings range from no expected increase in survival in 17 studies to an estimated 3.7 to 7 months' survival improvement noted in 3 studies. Most recently, a 1999 evidence report from the Agency for Healthcare Research and Quality and a 2000 overview from the Prostate Cancer Trialists Collaborative Group indicated that combined androgen blockade was associated with an approximately 3% to 5% increase in 5-year survival. We report herein a systematic review on combined androgen blockade performed by the Cochrane Collaborative Review Group on Prostate Diseases. Controlled trials that included a randomization of immediate nonsteroidal antiandrogens with castration versus castration alone for metastatic prostate cancer and provided information on survival were reviewed. Information on overall survival, toxicity, progression-free survival, cancer-specific survival, and type of nonsteroidal antiandrogen and castration therapies was abstracted by two independent reviewers. Twenty trials (n = 6320 patients) were included. The pooled odds ratio (OR) for overall survival with combined androgen blockade was 1.03 (95% confidence interval [CI] 0.85 to 1.25; n = 4970 from 13 trials), 1.16 (95% CI 1.00 to 1.33; n = 5286 from 14 trials), and 1.29 (95% CI 1.11 to 1.50; n = 3550 from 7 trials) at 1, 2, and 5 years, respectively. Progression-free survival was improved at 1 year (OR = 1.38; 95% CI 1.15 to 1.67; n = 2278 from 7 trials). Cancer-specific survival was improved at 5 years (OR = 1.58; 95% CI 1.05 to 2.37; n = 781 from 2 trials). When analysis was limited to studies identified as being of high quality, the pooled OR for overall survival progressively increased but was not significant at any follow-up interval. We find that there is a 5% improvement in the percentage of men surviving at 5 years (30% vs. 25%) with combined androgen blockade with nonsteroidal antiandrogens as well as improvements in progression-free survival at 1 year. Appropriate patients with metastatic prostate cancer should be informed of the potential benefits, toxicities, and out-of-pocket expenditures. JF - Urology AU - Schmitt, B AU - Wilt, T J AU - Schellhammer, P F AU - DeMasi, V AU - Sartor, O AU - Crawford, E D AU - Bennett, C L AD - Veterans Administration Chicago Healthcare System/Lakeside Division, Chicago, Illinois, USA. Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 727 EP - 732 VL - 57 IS - 4 KW - Androgen Antagonists KW - 0 KW - Imidazoles KW - Imidazolidines KW - nilutamide KW - 51G6I8B902 KW - Flutamide KW - 76W6J0943E KW - Index Medicus KW - Disease-Free Survival KW - Humans KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Male KW - Chemotherapy, Adjuvant KW - Orchiectomy KW - Prostatic Neoplasms -- mortality KW - Androgen Antagonists -- therapeutic use KW - Prostatic Neoplasms -- surgery KW - Imidazoles -- administration & dosage KW - Prostatic Neoplasms -- drug therapy KW - Flutamide -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77063879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urology&rft.atitle=Combined+androgen+blockade+with+nonsteroidal+antiandrogens+for+advanced+prostate+cancer%3A+a+systematic+review.&rft.au=Schmitt%2C+B%3BWilt%2C+T+J%3BSchellhammer%2C+P+F%3BDeMasi%2C+V%3BSartor%2C+O%3BCrawford%2C+E+D%3BBennett%2C+C+L&rft.aulast=Schmitt&rft.aufirst=B&rft.date=2001-04-01&rft.volume=57&rft.issue=4&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Urology&rft.issn=1527-9995&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-21 N1 - Date created - 2001-04-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Music and the PACU environment. AN - 77034710; 11290990 AB - Pain is a common problem in the PACU, resulting in negative respiratory, cardiovascular, gastrointestinal, renal, neuroendocrine, and autonomic nervous system consequences for patients. Pain relief contributes to improved patient outcomes and is also an important component of patient satisfaction, particularly in light of today's environment of high competition among hospitals for patients. Music and quiet conversation by staff, contributing to low noise levels in the PACU environment, have the potential to provide pain relief and improve patient satisfaction with the PACU experience. This study investigated the effect of soothing music and lowering noise levels on the pain experience of patients during their PACU stay. A quasiexperimental study was conducted with 2 groups of patients, one who listened to music on a day when staff kept extraneous noise at a minimum in the PACU (the experimental group) and one who experienced the typical PACU day (the control group). The study was conducted at a large Veterans Administration hospital in the Midwest. The sample consisted of 97 individuals undergoing same-day surgery from all surgery services except open heart. Pain was measured by using the 11-point Numerical Rating Scale (NRS). The experimental group experienced a significant reduction in pain from admission to the PACU until discharge. There was no significant decrease for the control group. Approximately 65% of both groups reported no pain on admission to PACU. The percentage of those in the experimental group with no pain increased to 74% at time of discharge. The percentage of those in the control group who reported no pain on discharge had decreased to 58%. A total of 99% of the participants remembered their PACU stay. When asked to remember aspects of comfort during the PACU stay, the experimental group reported (1) significantly less noise caused by staff voices and equipment, (2) greater perception of availability of nurses, and (3) significantly more positive perception of their PACU stay. The study findings support the potential for music played throughout the PACU stay to positively affect the pain experience and improve comfort among patients having surgery. Copyright 2001 by American Society of PeriAnesthesia Nurses. JF - Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses AU - Shertzer, K E AU - Keck, J F AD - Richard L. Roudebush Veterans Administration Hospital, Indianapolis, IN, USA. Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 90 EP - 102 VL - 16 IS - 2 SN - 1089-9472, 1089-9472 KW - Nursing KW - Attitude to Health KW - Humans KW - Pain Measurement KW - Midwestern United States KW - Middle Aged KW - Postanesthesia Nursing KW - Time Factors KW - Noise -- adverse effects KW - Male KW - Female KW - Hospitals, Veterans KW - Pain, Postoperative -- prevention & control KW - Pain, Postoperative -- etiology KW - Pain, Postoperative -- diagnosis KW - Recovery Room -- organization & administration KW - Music Therapy -- standards KW - Music Therapy -- methods KW - Health Facility Environment -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77034710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+perianesthesia+nursing+%3A+official+journal+of+the+American+Society+of+PeriAnesthesia+Nurses&rft.atitle=Music+and+the+PACU+environment.&rft.au=Shertzer%2C+K+E%3BKeck%2C+J+F&rft.aulast=Shertzer&rft.aufirst=K&rft.date=2001-04-01&rft.volume=16&rft.issue=2&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Journal+of+perianesthesia+nursing+%3A+official+journal+of+the+American+Society+of+PeriAnesthesia+Nurses&rft.issn=10899472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-15 N1 - Date created - 2001-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An integrative approach for studying the etiology of alcoholism and other addictions. AN - 72218397; 11665331 AB - Studies of alcoholism etiology often focus on genetic or psychosocial approaches, but not both. Greater understanding of the etiology of alcohol, tobacco and other addictions will come from integration of these research traditions. A research approach is outlined to test three models for the etiology of addictions--behavioral undercontrol, pharmacologic vulnerability, negative affect regulation--addressing key questions including (i) mediators of genetic effects, (ii) genotype-environment correlation effects, (iii) genotype x environment interaction effects, (iv) the developmental unfolding of genetic and environmental effects, (v) subtyping including identification of distinct trajectories of substance involvement, (vi) identification of individual genes that contribute to risk, and (vii) the consequences of excessive use. By using coordinated research designs, including prospective assessment of adolescent twins and their siblings and parents; of adult substance dependent and control twins and their MZ and DZ cotwins, the spouses of these pairs, and their adolescent offspring; and of regular families; by selecting for gene-mapping approaches sibships screened for extreme concordance or discordance on quantitative indices of substance use; and by using experimental (drug challenge) as well as survey approaches, a number of key questions concerning addiction etiology can be addressed. We discuss complementary strengths and weaknesses of different sampling strategies, as well as methods to implement such an integrated approach illustrated for the study of alcoholism etiology. A coordinated program of twin and family studies will allow a comprehensive dissection of the interplay of genetic and environmental risk-factors in the etiology of alcoholism and other addictions. JF - Twin research : the official journal of the International Society for Twin Studies AU - Jacob, T AU - Sher, K J AU - Bucholz, K K AU - True, W T AU - Sirevaag, E J AU - Rohrbaugh, J AU - Nelson, E AU - Neuman, R J AU - Todd, R D AU - Slutske, W S AU - Whitfield, J B AU - Kirk, K M AU - Martin, N G AU - Madden, P A AU - Heath, A C AD - Palo Alto Veterans Administration, Palo Alto, California, USA. Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 103 EP - 118 VL - 4 IS - 2 SN - 1369-0523, 1369-0523 KW - Index Medicus KW - Twin Studies as Topic -- methods KW - Models, Psychological KW - Risk Factors KW - Models, Genetic KW - Humans KW - Sampling Studies KW - Family KW - Parent-Child Relations KW - Research Design KW - Male KW - Female KW - Spouses KW - Alcoholism -- etiology KW - Behavior, Addictive -- etiology KW - Behavior, Addictive -- psychology KW - Diseases in Twins -- etiology KW - Alcoholism -- genetics KW - Behavior, Addictive -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72218397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Twin+research+%3A+the+official+journal+of+the+International+Society+for+Twin+Studies&rft.atitle=An+integrative+approach+for+studying+the+etiology+of+alcoholism+and+other+addictions.&rft.au=Jacob%2C+T%3BSher%2C+K+J%3BBucholz%2C+K+K%3BTrue%2C+W+T%3BSirevaag%2C+E+J%3BRohrbaugh%2C+J%3BNelson%2C+E%3BNeuman%2C+R+J%3BTodd%2C+R+D%3BSlutske%2C+W+S%3BWhitfield%2C+J+B%3BKirk%2C+K+M%3BMartin%2C+N+G%3BMadden%2C+P+A%3BHeath%2C+A+C&rft.aulast=Jacob&rft.aufirst=T&rft.date=2001-04-01&rft.volume=4&rft.issue=2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Twin+research+%3A+the+official+journal+of+the+International+Society+for+Twin+Studies&rft.issn=13690523&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-04 N1 - Date created - 2001-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prepulse inhibition of the acoustic startle response in cocaine-withdrawn rats. AN - 71133615; 11526973 AB - Prepulse inhibition (PPI) of startle is a sensorimotor gating task in which a low-intensity acoustic stimulus presented prior to a high-intensity, startle-eliciting stimulus can attenuate the acoustic startle response (ASR). Previous studies on startle reactivity in cocaine-withdrawn rats have found minimal changes; the present study extends this work to the gating of ASR. In Experiment 1, rats were injected daily with either saline or cocaine (30 mg/kg i.p.) for 2 weeks. ASR and PPI were measured prior to, and at 3- and 14-day withdrawal from, the chronic treatment. No effect of cocaine treatment was found on either measure. In Experiment 2, treatment was extended to 8 weeks, and an earlier withdrawal time point (1 day) was added. Rats treated with cocaine for 8 weeks exhibited lower startle reactivity during withdrawal compared with saline-treated controls. PPI did not differ between treatment groups. Thus, extended chronic treatment with cocaine rendered significant effects on startle responsivity. Further, this finding mirrors the blunted ASR exhibited in chronic cocaine users [Neuropsychopharmacology 22 (2000) 89.]. JF - Pharmacology, biochemistry, and behavior AU - Adams, J U AU - Efferen, T R AU - Duncan, E J AU - Rotrosen, J AD - Mental Health Research, New York Harbor Department of Veterans Affairs Health Care System, Department of Psychiatry, New York University School of Medicine, NY 10010, USA. adams.jill@new-york.va.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 753 EP - 759 VL - 68 IS - 4 SN - 0091-3057, 0091-3057 KW - Dopamine Uptake Inhibitors KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Acoustic Stimulation KW - Male KW - Reflex, Startle -- drug effects KW - Substance Withdrawal Syndrome -- physiopathology KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Reflex, Startle -- physiology KW - Neural Inhibition -- drug effects KW - Neural Inhibition -- physiology KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71133615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Prepulse+inhibition+of+the+acoustic+startle+response+in+cocaine-withdrawn+rats.&rft.au=Adams%2C+J+U%3BEfferen%2C+T+R%3BDuncan%2C+E+J%3BRotrosen%2C+J&rft.aulast=Adams&rft.aufirst=J&rft.date=2001-04-01&rft.volume=68&rft.issue=4&rft.spage=753&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-25 N1 - Date created - 2001-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Concurrent versus delayed smoking cessation treatment for persons in early alcohol recovery. A pilot study. AN - 71110253; 11516593 AB - This pilot study investigated the efficacy of initiating a smoking cessation intervention early in inpatient treatment for alcohol dependence versus shortly after an inpatient stay. Thirty-six male smokers recruited from an inpatient substance abuse treatment program were randomly assigned to begin smoking cessation either two weeks (concurrent treatment) or six weeks (delayed treatment) after admission to the substance abuse program. Smoking cessation treatment involved three sessions of individual smoking cessation treatment plus eight weeks of transdermal nicotine replacement. Significantly fewer participants began the delayed treatment than the concurrent treatment. Few participants were smoking-abstinent at follow-up, and the timing of treatment onset did not have an impact on smoking outcome. Clinical trials with larger samples may be needed to better evaluate the efficacy of concurrent versus delayed treatment and to test the efficacy of more aggressive interventions with smokers in early alcohol recovery. JF - Journal of substance abuse treatment AU - Kalman, D AU - Hayes, K AU - Colby, S M AU - Eaton, C A AU - Rohsenow, D J AU - Monti, P M AD - Boston University Medical School and Edith Nourse Rogers Memorial Veterans Affairs Medical Center, Boston, MA, USA. Kalman.David@bedford.va.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 233 EP - 238 VL - 20 IS - 3 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Substance Abuse Treatment Centers KW - Humans KW - Treatment Outcome KW - Time Factors KW - Male KW - Smoking Cessation -- psychology KW - Tobacco Use Disorder -- drug therapy KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71110253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Concurrent+versus+delayed+smoking+cessation+treatment+for+persons+in+early+alcohol+recovery.+A+pilot+study.&rft.au=Kalman%2C+D%3BHayes%2C+K%3BColby%2C+S+M%3BEaton%2C+C+A%3BRohsenow%2C+D+J%3BMonti%2C+P+M&rft.aulast=Kalman&rft.aufirst=D&rft.date=2001-04-01&rft.volume=20&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-11-01 N1 - Date created - 2001-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Girard's reagent P derivative of beta-Apo-8'-carotenal: a potent photoprotective agent. AN - 70811436; 11332029 AB - A cationic carotenoid derivative (GRP-carotenal) was synthesized by the reaction of Girard's reagent P and beta-apo-8'-carotenal. The singlet-oxygen quenching constants for GRP-carotenal were 1.3 +/- 0.1 x 10(10) and 1.0 +/- 0.1 x 10(10) M-1 s-1 in acetonitrile and in detergent micelles, respectively. Photosensitized damage to K562 leukemia cells from cis-di(4-sulfonatophenyl)diphenylporphine, hypericin and protoporphyrin IX was inhibited by GRP-carotenal under conditions where beta-apo-8'-carotenal, beta-carotene and crocetin were ineffective. The unique cytoprotective properties of GRP-carotenal, relative to the other carotenoids studied, could not be explained by the differences in the cell content of the various carotenoids or by the changes in the cell content of the photosensitizers used. Photosensitizer fluorescence from labeled K562 cells was reduced by GRP-carotenal but not by the other carotenoids studied. The novel photoprotective properties of GRP-carotenal may be due to its subcellular distribution. In photosensitizer-containing detergent micelles, novel properties of GRP-carotenal were not apparent. None of the carotenoids studied reduced photosensitizer fluorescence or singlet-oxygen generation. Singlet-oxygen quenching by GRP-carotenal and by beta-apo-8'-carotenal were roughly the same. Crocetin has a singlet-oxygen quenching constant that is about a factor of five lower. Singlet-oxygen quenching by beta-carotene was limited by its aggregation. JF - Photochemistry and photobiology AU - Kanofsky, J R AU - Sima, P D AD - Medical Service, Edward Hines Jr., Department of Veterans Affairs Hospital, Hines, IL, USA. jeff.kanofsky@med.va.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 349 EP - 358 VL - 73 IS - 4 SN - 0031-8655, 0031-8655 KW - GRP-carotenal KW - 0 KW - Photosensitizing Agents KW - Porphyrins KW - Protoporphyrins KW - di(4-sulfonatophenyl)diphenylporphine KW - Singlet Oxygen KW - 17778-80-2 KW - crocetin KW - 20TC155L9C KW - Carotenoids KW - 36-88-4 KW - Perylene KW - 5QD5427UN7 KW - hypericin KW - 7V2F1075HD KW - protoporphyrin IX KW - C2K325S808 KW - Oxygen KW - S88TT14065 KW - apocarotenal KW - V22N3E2U32 KW - Index Medicus KW - Photochemistry KW - Molecular Structure KW - Porphyrins -- toxicity KW - Photosensitizing Agents -- toxicity KW - Protoporphyrins -- toxicity KW - Humans KW - Oxygen -- chemistry KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Perylene -- analogs & derivatives KW - Tumor Cells, Cultured -- drug effects KW - Perylene -- toxicity KW - Carotenoids -- chemistry KW - K562 Cells -- drug effects KW - Carotenoids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70811436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Girard%27s+reagent+P+derivative+of+beta-Apo-8%27-carotenal%3A+a+potent+photoprotective+agent.&rft.au=Kanofsky%2C+J+R%3BSima%2C+P+D&rft.aulast=Kanofsky&rft.aufirst=J&rft.date=2001-04-01&rft.volume=73&rft.issue=4&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-24 N1 - Date created - 2001-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Health Status and Quality of Life in Romania AN - 61468438; 200105086 AB - The objective of this study was to examine health status & quality of life in northwestern Romania. The study utilized a descriptive, correlational design to examine the major study variables measured in 401 patients seen at a clinic. Instruments included the Medical Outcomes Study Short Form 36-item survey (MOSSF-36) as a measure of health status, the Quality of Life Index (QLI) as a measure of quality of life, & a demographic/health survey. The rationale for the study was to explore the crosscultural aspects of health status & quality of life in this former Eastern bloc country. Questionnaires were translated through classical forward & backward methods to achieve crosscultural comparability. Interviewers administered the questionnaires to participants at the clinic. The study findings indicated that health status was significantly related to quality of life. Scores on the MOSSF-36 indicated that the Romanian sample most often experienced limitations due to pain (66.9%). Other frequently cited reasons for clinic visits included consultation with health care provider, & cardiovascular, respiratory, & digestive problems. International measurement of outcome variables such as health status & quality of life is an important focus for interdisciplinary research. The link between these variables may provide further data to support the role of health care providers in assessment & intervention to improve quality of life. 4 Tables, 30 References. Adapted from the source document. JF - Issues in Interdisciplinary Care AU - Lakey, Cynthia K AU - Nicholas, Patrice Kenneally AU - Wolf, Karen A AU - Leuner, Jean D'Meza AU - Corless, Inge B AU - Paul-Simon, Alexandra AD - Veterans Administration Medical Center, Boston, MA Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 129 EP - 136 VL - 3 IS - 2 SN - 1531-5150, 1531-5150 KW - Postcommunist Societies KW - Romania KW - Quality of Life KW - Clinics KW - Patients KW - Health KW - Crosscultural Analysis KW - Health Care Utilization KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61468438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Issues+in+Interdisciplinary+Care&rft.atitle=Health+Status+and+Quality+of+Life+in+Romania&rft.au=Lakey%2C+Cynthia+K%3BNicholas%2C+Patrice+Kenneally%3BWolf%2C+Karen+A%3BLeuner%2C+Jean+D%27Meza%3BCorless%2C+Inge+B%3BPaul-Simon%2C+Alexandra&rft.aulast=Lakey&rft.aufirst=Cynthia&rft.date=2001-04-01&rft.volume=3&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Issues+in+Interdisciplinary+Care&rft.issn=15315150&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health; Quality of Life; Romania; Postcommunist Societies; Patients; Clinics; Crosscultural Analysis; Health Care Utilization ER - TY - JOUR T1 - A Psychometric Evaluation of the BDI-II in Treatment-Seeking Substance Abusers AN - 61441659; 200200638 AB - The Beck Depression Inventory-II (BDI-II) was administered to 416 consecutive male admissions to a 28-day residential chemical dependence treatment program as part of a routine intake procedure. Psychometric analyses revealed that the BDI-II scores were internally consistent in this treatment-seeking population based on coefficient alpha. The mean BDI-II score for patients in this study was higher than that noted for other clinical samples in previous studies. The use of BDI-II for clinical decision making with chemically dependent individuals is discussed in light of this elevated distribution of scores. Confirmatory factor-analytic examinations of the instrument revealed that a three-factor model, with cognitive, affective, & somatic symptoms loading as separate factors, provided the most adequate account of the data. In total, the study supported the use of the BDI-II for the assessment of depression in chemically dependent male patients entering a residential treatment program at a VAMC facility, provided population-specific normative data is utilized for making clinical decisions. 3 Tables, 1 Figure, 27 References. Adapted from the source document. JF - Journal of Substance Abuse Treatment AU - Buckley, Todd C AU - Parker, Jefferson D AU - Heggie, Jennifer AD - Boston Veterans Affairs Medical Center, MA todd.buckley@med.va.gov Y1 - 2001/04// PY - 2001 DA - April 2001 SP - 197 EP - 204 VL - 20 IS - 3 SN - 0740-5472, 0740-5472 KW - Help Seeking Behavior KW - Substance Abuse KW - Treatment Programs KW - Males KW - Mississippi KW - Psychometric Analysis KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61441659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=A+Psychometric+Evaluation+of+the+BDI-II+in+Treatment-Seeking+Substance+Abusers&rft.au=Buckley%2C+Todd+C%3BParker%2C+Jefferson+D%3BHeggie%2C+Jennifer&rft.aulast=Buckley&rft.aufirst=Todd&rft.date=2001-04-01&rft.volume=20&rft.issue=3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Substance Abuse; Psychometric Analysis; Help Seeking Behavior; Treatment Programs; Males; Mississippi ER - TY - JOUR T1 - Severe exercise alters the strength and mechanisms of the muscle metaboreflex AN - 18118196; 5210192 AB - Previous studies have shown that in dogs performing mild to moderate treadmill exercise, partial graded reductions in hindlimb blood flow cause active skeletal muscle to become ischemic and metabolites to accumulate thus evoking the muscle metaboreflex. This leads to a substantial reflex increase in mean arterial pressure (MAP) mediated almost solely via a rise in cardiac output (CO). However, during severe exercise CO is likely near maximal and thus metaboreflex-mediated increases in MAP may be attenuated. We therefore evoked the metaboreflex via partial graded reductions in hindlimb blood flow in seven dogs during mild, moderate, and severe treadmill exercise. During mild and moderate exercise there was a large rise in CO (1.5 plus or minus 0.2 and 2.2 plus or minus 0.3 1/min, respectively), whereas during severe exercise no significant increase in CO occurred. The rise in CO caused a marked pressor response that was significantly attenuated during severe exercise (26.3 plus or minus 7.0, 33.2 plus or minus 5.6, and 12.2 plus or minus 4.8 mmHg, respectively). We conclude that during severe exercise the metaboreflex pressor response mechanisms are altered such that the ability of this reflex to increase CO is abolished, and reduced pressor response occurs only via peripheral vasoconstriction. This shift in mechanisms likely limits the effectiveness of the metaboreflex to increase blood flow to ischemic active skeletal muscle. Furthermore, because the metaboreflex is a flow-raising reflex and not a pressure-raising reflex, it may be most appropriate to describe the metaboreflex magnitude based on its ability to evoke a rise in CO and not a rise in MAP. JF - American Journal of Physiology: Heart and Circulatory Physiology AU - Augustyniak, R A AU - Collins, H L AU - Ansorge, E J AU - Rossi, N F AU - O'Leary, D S AD - Department of Medicine, John D. Dingell Veterans Administration Medical Center, Detroit, Michigan 48201, USA Y1 - 2001/04// PY - 2001 DA - Apr 2001 SP - H1645 EP - H1652 VL - 280 IS - 4 SN - 0363-6135, 0363-6135 KW - Physical Education Index KW - Heart KW - Exercise physiology KW - Strength KW - Cardiac output KW - Blood flow KW - Circulatory system KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18118196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Heart+and+Circulatory+Physiology&rft.atitle=Severe+exercise+alters+the+strength+and+mechanisms+of+the+muscle+metaboreflex&rft.au=Augustyniak%2C+R+A%3BCollins%2C+H+L%3BAnsorge%2C+E+J%3BRossi%2C+N+F%3BO%27Leary%2C+D+S&rft.aulast=Augustyniak&rft.aufirst=R&rft.date=2001-04-01&rft.volume=280&rft.issue=4&rft.spage=H1645&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Heart+and+Circulatory+Physiology&rft.issn=03636135&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Strength; Exercise physiology; Heart; Circulatory system; Blood flow; Cardiac output ER - TY - JOUR T1 - The Military Environment: Risk Factors for Women's Non-Fatal Assaults AN - 17872407; 5120577 AB - Little is known regarding environmental exposures for non-fatal violence toward women in the workplace. We sought to identify factors associated with non-fatal physical assault occurring to women during military service. A cross-sectional telephone survey of a national sample of 558 women veterans who served in Vietnam and subsequent eras of military service was conducted; 537 women were interviewed. Twenty-three percent experienced non-fatal physical assault during military service. Rates of assault were consistent across eras of service. Military environmental exposures, including sexual harassment allowed by officers (P < 0.0001) and unwanted sexual advances while on duty (P < .0001) and in sleeping quarters (P < 0.0001), were independent risk factors for assault. Environmental factors in the military workplace, including leadership behavior, appeared to promote violence toward military women. Such occupational factors can be identified and should be eliminated. JF - Journal of Occupational and Environmental Medicine AU - Sadler, A G AU - Booth, B M AU - Cook, B L AU - Torner, J C AU - Doebbeling, B N AD - Post-Traumatic Stress Disorder Clinical Team Coordinator, (116B) Psychology Service, Veterans Administration Medical Center, Highway 6 West, Iowa City, IA 52246, USA Y1 - 2001/04// PY - 2001 DA - Apr 2001 SP - 325 EP - 334 VL - 43 IS - 4 SN - 1076-2752, 1076-2752 KW - physical assault KW - Risk Abstracts; Health & Safety Science Abstracts KW - Occupational safety KW - Violence KW - Females KW - Military KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17872407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=The+Military+Environment%3A+Risk+Factors+for+Women%27s+Non-Fatal+Assaults&rft.au=Sadler%2C+A+G%3BBooth%2C+B+M%3BCook%2C+B+L%3BTorner%2C+J+C%3BDoebbeling%2C+B+N&rft.aulast=Sadler&rft.aufirst=A&rft.date=2001-04-01&rft.volume=43&rft.issue=4&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Females; Military; Occupational safety; Violence ER - TY - JOUR T1 - Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection. AN - 76951810; 11237812 AB - Immunosuppressed Swiss Black mice deficient in surfactant protein A (SP-A(-/-)) and wild-type control mice (SP-A(+/+)) were exposed to Pneumocystis carinii by environmental exposure, intratracheal inoculation, and direct exposure to other infected animals. The frequency and intensity of P. carinii infection were significantly greater in the SP-A(-/-) mice by all 3 methods of exposure. P. carinii free of SP-A and alveolar macrophages were isolated from SP-A(-/-) mice and were tested in an in vitro attachment assay. Pretreatment of P. carinii with human SP-A resulted in a significant dose-dependent increase of the adherence of P. carinii to the macrophages. Thus, SP-A plays a role in host defense against P. carinii in vivo, perhaps by functioning as a nonimmune opsonin. JF - The Journal of infectious diseases AU - Linke, M J AU - Harris, C E AU - Korfhagen, T R AU - McCormack, F X AU - Ashbaugh, A D AU - Steele, P AU - Whitsett, J A AU - Walzer, P D AD - Research Service, Department of Veterans Affairs Medical Center, and Divisions of Infectious Diseases and Pulmonary/Critical Care Medicine, University of Cincinnati, Cincinnati, OH 45220, USA. Michael.Linke@med.va.gov Y1 - 2001/03/15/ PY - 2001 DA - 2001 Mar 15 SP - 943 EP - 952 VL - 183 IS - 6 SN - 0022-1899, 0022-1899 KW - Proteolipids KW - 0 KW - Pulmonary Surfactant-Associated Protein A KW - Pulmonary Surfactant-Associated Proteins KW - Pulmonary Surfactants KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Pneumonia, Pneumocystis -- immunology KW - Disease Susceptibility KW - Mice KW - Lung -- pathology KW - Mice, Knockout KW - Pneumonia, Pneumocystis -- microbiology KW - Pneumonia, Pneumocystis -- pathology KW - Cells, Cultured KW - Trachea -- microbiology KW - Environmental Exposure KW - Mice, Inbred C3H KW - Bacterial Adhesion KW - Macrophages, Alveolar -- immunology KW - Lung -- microbiology KW - Proteolipids -- genetics KW - Proteolipids -- pharmacology KW - Pulmonary Surfactants -- physiology KW - Pneumocystis -- cytology KW - Pulmonary Surfactants -- genetics KW - Pulmonary Surfactants -- pharmacology KW - Immunocompromised Host KW - Proteolipids -- physiology KW - Pneumocystis -- pathogenicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76951810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Immunosuppressed+surfactant+protein+A-deficient+mice+have+increased+susceptibility+to+Pneumocystis+carinii+infection.&rft.au=Linke%2C+M+J%3BHarris%2C+C+E%3BKorfhagen%2C+T+R%3BMcCormack%2C+F+X%3BAshbaugh%2C+A+D%3BSteele%2C+P%3BWhitsett%2C+J+A%3BWalzer%2C+P+D&rft.aulast=Linke&rft.aufirst=M&rft.date=2001-03-15&rft.volume=183&rft.issue=6&rft.spage=943&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-05 N1 - Date created - 2001-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Darley and the Efficacy of Language Rehabilitation in Aphasia AN - 85346114; llba-200107388 AB - The efficacy of language rehabilitation programs in helping individuals with aphasia is investigated. An overview of Fredric Darley's (1972) examination of the effectiveness of language rehabilitation in aphasia is presented; the significant influence of Darley's research on future studies of language rehabilitation's efficacy is also noted. R. R. Robey & M. C. Schultz's (1998) provision of precise definitions for aphasiological terminology & recommendation that aphasiological research employ a 5-phase outcome research model are discussed; in addition, Birch & Davis Associates's (1997) scale for assessing the quality of evidence is deemed another important methods for organizing outcomes data. Existing research that has used meta-analytical approaches, randomized controlled trials, self-selected methods, & comparison of parallel group designs to assess the efficacy of language rehabilitation in aphasia is reviewed. Although language rehabilitation does produce measurable gains in aphasic individuals, it is concluded that additional research is needed to determine whether language rehabilitation therapy is cost effective. 46 References. J. W. Parker JF - Aphasiology AU - Wertz, Robert T AU - Irwin, William H AD - VA Medical Center, Nashville, TN robert.wertz@med.va.gov Y1 - 2001/03// PY - 2001 DA - Mar 2001 SP - 231 EP - 247 VL - 15 IS - 3 SN - 0268-7038, 0268-7038 KW - *Language Therapy (44400) KW - *Linguists (48250) KW - *Aphasia (03400) KW - *History of Linguistics (32150) KW - article KW - 6812: special education; language therapy KW - 4810: history of linguistics; history of linguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85346114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Darley+and+the+Efficacy+of+Language+Rehabilitation+in+Aphasia&rft.au=Wertz%2C+Robert+T%3BIrwin%2C+William+H&rft.aulast=Wertz&rft.aufirst=Robert&rft.date=2001-03-01&rft.volume=15&rft.issue=3&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2003-10-01 N1 - Last updated - 2014-06-17 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - *Language Therapy (44400); *Aphasia (03400); *History of Linguistics (32150); *Linguists (48250) ER - TY - JOUR T1 - Type and Severity of Aphasia during the First Seven Months Poststroke AN - 85341648; llba-200107372 AB - Empirical, prognostic evidence of the influence of type on severity of & recovery from aphasia is limited. Forty-one treated adults with aphasia were administered four standardized language impairment & communication activity limitation tests at approximately 1 month poststroke. Tests were readministered 3 & 6 months later to determine whether change in severity &/or type of aphasia had occurred. On all tests, initial severity differed significantly among types. Rate of recovery also differed among types: Some types demonstrated significant amounts of improvement, but others did not, &, while language impairment outcome at 7 months poststroke differed significantly among types, the results varied by test. Finally, more than one third of the patients changed type during the 6-month period. Percentages & patterns of change varied by time, poststroke, of classification. 6 Tables, 4 Figures, 54 References. Adapted from the source document JF - Journal of Medical Speech-Language Pathology AU - Ross, Katherine B AU - Wertz, Robert T AD - Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ katherine.ross3@med.va.gov Y1 - 2001/03// PY - 2001 DA - Mar 2001 SP - 31 EP - 53 VL - 9 IS - 1 SN - 1065-1438, 1065-1438 KW - *Prognostic Tests (68150) KW - *Aphasia (03400) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85341648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Speech-Language+Pathology&rft.atitle=Type+and+Severity+of+Aphasia+during+the+First+Seven+Months+Poststroke&rft.au=Ross%2C+Katherine+B%3BWertz%2C+Robert+T&rft.aulast=Ross&rft.aufirst=Katherine&rft.date=2001-03-01&rft.volume=9&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Speech-Language+Pathology&rft.issn=10651438&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2003-10-01 N1 - Last updated - 2014-06-17 N1 - CODEN - JSLPEP N1 - SubjectsTermNotLitGenreText - *Aphasia (03400); *Prognostic Tests (68150) ER - TY - JOUR T1 - Recent insights into the role of tumor necrosis factor in the failing heart. AN - 77061494; 11309526 AB - Recent studies have identified the importance of biologically active molecules such as neurohormones in disease progression in heart failure. More recently it has become apparent that in addition to neurohormones, another portfolio of biologically active molecules termed cytokines, are also expressed in the setting of heart failure. This article will review recent clinical and experimental material which suggests that tumor necrosis factor (TNF), a pro-inflammatory cytokine, may contribute to disease progression in heart failure by virtue of the direct toxic effects that this molecule exerts on the heart and circulation. JF - Heart failure reviews AU - Mann, D L AD - Winters Center for Heart Failure Research, Cardiology Section, Department of Medicine, Veterans Administration Medical Center and Baylor College of Medicine, 2002 Holcombe Blvd., Houston TX 77030, USA. dmann@bcm.tmc.edu Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 71 EP - 80 VL - 6 IS - 2 SN - 1382-4147, 1382-4147 KW - Tumor Necrosis Factor-alpha KW - 0 KW - Index Medicus KW - Humans KW - Disease Progression KW - Gene Expression Regulation KW - Heart Failure -- genetics KW - Heart Failure -- metabolism KW - Tumor Necrosis Factor-alpha -- metabolism KW - Tumor Necrosis Factor-alpha -- genetics KW - Heart Failure -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77061494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Heart+failure+reviews&rft.atitle=Recent+insights+into+the+role+of+tumor+necrosis+factor+in+the+failing+heart.&rft.au=Mann%2C+D+L&rft.aulast=Mann&rft.aufirst=D&rft.date=2001-03-01&rft.volume=6&rft.issue=2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Heart+failure+reviews&rft.issn=13824147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cardiovascular and renal effects of COX-2-specific inhibitors: recent insights and evolving clinical implications. AN - 77058859; 11304661 JF - American journal of therapeutics AU - Epstein, M AD - Nephrology Section, University of Miami School of Medicine, Miami, FL 33125, USA. murray.epstein@med.va.gov PY - 2001 SP - 81 EP - 83 VL - 8 IS - 2 SN - 1075-2765, 1075-2765 KW - Cyclooxygenase Inhibitors KW - 0 KW - Lactones KW - Pyrazoles KW - Sulfonamides KW - Sulfones KW - rofecoxib KW - 0QTW8Z7MCR KW - Celecoxib KW - JCX84Q7J1L KW - Index Medicus KW - Arthritis, Rheumatoid -- drug therapy KW - Edema -- chemically induced KW - Hypertension -- chemically induced KW - Humans KW - Osteoarthritis -- drug therapy KW - Kidney Diseases -- chemically induced KW - Lactones -- adverse effects KW - Cyclooxygenase Inhibitors -- adverse effects KW - Sulfonamides -- adverse effects KW - Lactones -- administration & dosage KW - Cyclooxygenase Inhibitors -- administration & dosage KW - Kidney -- drug effects KW - Heart -- drug effects KW - Sulfonamides -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77058859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+therapeutics&rft.atitle=Cardiovascular+and+renal+effects+of+COX-2-specific+inhibitors%3A+recent+insights+and+evolving+clinical+implications.&rft.au=Epstein%2C+M&rft.aulast=Epstein&rft.aufirst=M&rft.date=2001-03-01&rft.volume=8&rft.issue=2&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=American+journal+of+therapeutics&rft.issn=10752765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-14 N1 - Date created - 2001-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Olanzapine-lnduced hyperglycemic nonketonic coma. AN - 76988064; 11261526 AB - To report a case of olanzapine-induced hyperglycemia leading to a hyperosmolar, hyperglycemic, nonketonic coma. A 51-year-old, 85.5-kg (ideal body weight 79.9 kg), white man presented to a Veterans Affairs hospital with a serum glucose concentration of 1596 mg/dL. Soon thereafter, he went into a hyperosmolar, hyperglycemic, nonketonic coma. Olanzapine therapy had been instituted less than six months prior to this event; approximately two months before this event, his blood glucose was 108 mg/dL. Eight days after stopping olanzapine, the glucose concentration returned to normal, and the patient no longer required insulin nor any other glucose-lowering agents. The insulin resistance caused by olanzapine is normally attributed to the weight gain associated with the drug. In this patient, it appears that olanzapine caused hyperglycemia by a mechanism other than weight gain. This case report and others from the literature suggest that olanzapine therapy may induce hyperglycemia in some patients. JF - The Annals of pharmacotherapy AU - Roefaro, J AU - Mukherjee, S M AD - Veterans Affairs Boston Healthcare System, MA 02130-4817, USA. roefaro.john@boston.va.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 300 EP - 302 VL - 35 IS - 3 SN - 1060-0280, 1060-0280 KW - Antipsychotic Agents KW - 0 KW - Blood Glucose KW - Benzodiazepines KW - 12794-10-4 KW - Pirenzepine KW - 3G0285N20N KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - Blood Glucose -- metabolism KW - Humans KW - Bipolar Disorder -- drug therapy KW - Middle Aged KW - Stress Disorders, Post-Traumatic -- drug therapy KW - Male KW - Hyperglycemic Hyperosmolar Nonketotic Coma -- blood KW - Pirenzepine -- analogs & derivatives KW - Antipsychotic Agents -- therapeutic use KW - Antipsychotic Agents -- adverse effects KW - Pirenzepine -- therapeutic use KW - Pirenzepine -- adverse effects KW - Hyperglycemic Hyperosmolar Nonketotic Coma -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76988064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Olanzapine-lnduced+hyperglycemic+nonketonic+coma.&rft.au=Roefaro%2C+J%3BMukherjee%2C+S+M&rft.aulast=Roefaro&rft.aufirst=J&rft.date=2001-03-01&rft.volume=35&rft.issue=3&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-21 N1 - Date created - 2001-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Octreotide potentiates PKC-dependent vasoconstrictors in portal-hypertensive and control rats. AN - 76977248; 11231951 AB - The effect of octreotide on vascular tone in the superior mesenteric artery (SMA) was studied in portal-hypertensive (portal vein-ligated) and sham-operated rats. In vitro-perfused SMA vascular beds were tested for the cumulative dose-response to octreotide at baseline conditions and after preconstriction with different vasoconstrictors (alpha1-agonist methoxamine, endothelin [ET-1], phorbol ester [PdBu], and potassium chloride [KCl]). Octreotide did not affect baseline perfusion pressures (without preconstriction). alpha1-Adrenergic-, ET-1-, and PdBu-, but not KCl-, induced vasoconstriction was significantly potentiated by octreotide. This effect was dose-dependent and not different in portal vein-ligated and sham rats. Amplification of alpha1-adrenergic vasoconstriction by octreotide was significantly enhanced by nitric oxide inhibition (N(W)-nitro-L-arginine, 10(-4) mol/L) as well as by removal of the endothelium, and was completely suppressed by inhibition of protein kinase C (calphostin C, 1 micromol/L), phospholipase A2 (quinacrine, 5 micromol/L), and cyclooxygenase (indomethacin, 20 micromol/L). Not directly, but in the presence of vasoconstrictors involving activation of protein kinase C, octreotide exerts a local vasoconstrictive effect on vascular smooth muscle of SMA. This potentiation is equipotent in portal vein-ligated and sham rats, immediate in onset, and mediated via phospholipase A2 and cyclooxygenase-derived prostanoids. This indicates that in preprandial conditions octreotide enhances the vasoconstrictive effect of dependent vasoconstrictors. JF - Gastroenterology AU - Wiest, R AU - Tsai, M H AU - Groszmann, R J AD - Hepatic Hemodynamic Laboratory, Veterans Administration Medical Center, West Haven, Connecticut 06516, USA. Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 975 EP - 983 VL - 120 IS - 4 SN - 0016-5085, 0016-5085 KW - Adrenergic alpha-Agonists KW - 0 KW - Endothelin-1 KW - Vasoconstrictor Agents KW - Nitric Oxide KW - 31C4KY9ESH KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Methoxamine KW - HUQ1KC1YLI KW - Octreotide KW - RWM8CCW8GP KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Methoxamine -- pharmacology KW - Reference Values KW - Adrenergic alpha-Agonists -- pharmacology KW - Dose-Response Relationship, Drug KW - Nitric Oxide -- physiology KW - Endothelium, Vascular -- physiopathology KW - Phorbol 12,13-Dibutyrate -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Drug Synergism KW - Endothelin-1 -- pharmacology KW - Male KW - Vasoconstrictor Agents -- pharmacology KW - Octreotide -- pharmacology KW - Protein Kinase C -- physiology KW - Hypertension, Portal -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76977248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Octreotide+potentiates+PKC-dependent+vasoconstrictors+in+portal-hypertensive+and+control+rats.&rft.au=Wiest%2C+R%3BTsai%2C+M+H%3BGroszmann%2C+R+J&rft.aulast=Wiest&rft.aufirst=R&rft.date=2001-03-01&rft.volume=120&rft.issue=4&rft.spage=975&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-19 N1 - Date created - 2001-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Biliary cyst fluid from common bile duct-ligated rats stimulates endothelial nitric oxide synthase in pulmonary artery endothelial cells: a potential role in hepatopulmonary syndrome. AN - 76968580; 11230754 AB - The hepatopulmonary syndrome (HPS) results from pulmonary microvascular dilatation in cirrhosis and is associated with increased pulmonary endothelial nitric oxide synthase (eNOS) levels. In the common bile duct ligation (CBDL) model, endothelin-1 (ET-1) released from the liver contributes to the rise in pulmonary eNOS and intrapulmonary vasodilatation. Whether substances, including ET-1, are found in the biliary tree and selectively enter the circulation after CBDL to influence the pulmonary vasculature is unknown. We assessed if control bile and fluid obtained from the obstructed biliary tree in CBDL animals contains ET-1 and alters eNOS expression and activity in bovine pulmonary artery endothelial cells (BPAECs). Control bile and biliary cyst fluid contained concentrations of ET-1 25- to 42-fold normal plasma levels, and hepatic venous concentrations of ET-1 were selectively increased after CBDL. Biliary cyst fluid caused a dose-dependent induction of eNOS messenger RNA (mRNA) (1.9-fold control), protein (2.5-fold control), and enzyme activity (2.2-fold control) maximal at a 1:10 dilution. The increases were associated with enhanced nitric oxide (NO) production (3.1-fold control) and were inhibitable with an ET(B) receptor antagonist. Bile from sham and portal vein-ligated animals did not increase eNOS expression and at dilutions of 1:100 and 1:10 caused cell toxicity. These results show that bile and biliary cyst fluid contain high concentrations of ET-1 that are specifically increased in hepatic venous blood after CBDL. Biliary cyst fluid increases eNOS expression and activity in an ET(B) receptor-dependent manner in BPAECs. The findings suggest a novel mechanism for the susceptibility of CBDL animals to the HPS. JF - Hepatology (Baltimore, Md.) AU - Liu, L AU - Zhang, M AU - Luo, B AU - Abrams, G A AU - Fallon, M B AD - Department of Internal Medicine, Liver Center, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, AL, USA. Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 722 EP - 727 VL - 33 IS - 3 SN - 0270-9139, 0270-9139 KW - Endothelin-1 KW - 0 KW - Nitrites KW - RNA, Messenger KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Nitric Oxide Synthase Type III KW - Nos3 protein, rat KW - Index Medicus KW - Animals KW - Nitrites -- metabolism KW - Hepatopulmonary Syndrome -- physiopathology KW - Rats KW - Endothelin-1 -- physiology KW - Rats, Sprague-Dawley KW - Cattle KW - RNA, Messenger -- metabolism KW - Cells, Cultured KW - Common Bile Duct KW - Ligation KW - Male KW - Body Fluids -- physiology KW - Endothelium, Vascular -- enzymology KW - Endothelium, Vascular -- cytology KW - Bile Duct Diseases -- metabolism KW - Nitric Oxide Synthase -- genetics KW - Cysts -- metabolism KW - Pulmonary Artery -- cytology KW - Nitric Oxide Synthase -- metabolism KW - Pulmonary Artery -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76968580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Biliary+cyst+fluid+from+common+bile+duct-ligated+rats+stimulates+endothelial+nitric+oxide+synthase+in+pulmonary+artery+endothelial+cells%3A+a+potential+role+in+hepatopulmonary+syndrome.&rft.au=Liu%2C+L%3BZhang%2C+M%3BLuo%2C+B%3BAbrams%2C+G+A%3BFallon%2C+M+B&rft.aulast=Liu&rft.aufirst=L&rft.date=2001-03-01&rft.volume=33&rft.issue=3&rft.spage=722&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-12 N1 - Date created - 2001-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of TNK with wild-type tissue plasminogen activator in a rabbit embolic stroke model. AN - 76957971; 11239197 AB - Tissue plasminogen activator (tPA) is an effective treatment for stroke, but its utility is limited by fear of cerebral hemorrhage. Tenecteplase (TNK), a genetically modified form of wild-type tPA, exhibits a longer biological half-life and greater fibrin specificity, features that could lead to fewer cerebral hemorrhages than wild-type tPA in stroke patients. We injected radiolabeled blood clots into the cerebral circulation of New Zealand White rabbits. One hour later, we administered tPA (n=57), 0.6 mg/kg TNK (n=43), 1.5 mg/kg TNK (n=27), or vehicle control (n=37). A blinded observer examined the brains for macroscopic hemorrhage using a semiquantitative score. We estimated thrombolysis by assessing the amount of radiolabel remaining in the cerebral vessels postmortem. Both wild-type tPA and TNK caused thrombolysis in most subjects. Hemorrhage was detected in 26% (6/23) of the control group, 66% (27/41) of the wild-type tPA group, 55% (16/29) in the 0.6-mg/kg TNK group, and 53% (9/17) in the 1.5-mg/kg TNK group (P:<0.05, chi(2) test). The tPA group was statistically significantly different from the control group, but the TNK and tPA groups did not differ from each other. Neither TNK nor tPA affected the size of the hemorrhages. TNK shows comparable rates of recanalization compared with wild-type tPA in a model of embolic stroke. While tPA increases hemorrhage rate, the hemorrhage associated with TNK treatment is not statistically different compared with controls or the tPA group. These findings suggest that TNK shows promise as an alternative thrombolytic treatment for stroke, but we could not demonstrate improved safety compared with wild-type tPA. JF - Stroke AU - Chapman, D F AU - Lyden, P AU - Lapchak, P A AU - Nunez, S AU - Thibodeaux, H AU - Zivin, J AD - Department of Neurosciences, University of California at San Diego School of Medicine, and Department of Neurology, Veterans Administration Medical Center, San Diego, CA, USA. Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 748 EP - 752 VL - 32 IS - 3 KW - TNK-tissue plasminogen activator KW - EC 3.4.21.68 KW - Tissue Plasminogen Activator KW - Index Medicus KW - Animals KW - Cerebral Hemorrhage -- prevention & control KW - Treatment Outcome KW - Disease Models, Animal KW - Cerebral Hemorrhage -- pathology KW - Rabbits KW - Cerebral Hemorrhage -- etiology KW - Thrombolytic Therapy -- adverse effects KW - Intracranial Embolism -- complications KW - Stroke -- drug therapy KW - Stroke -- complications KW - Tissue Plasminogen Activator -- therapeutic use KW - Stroke -- pathology KW - Tissue Plasminogen Activator -- adverse effects KW - Intracranial Embolism -- pathology KW - Intracranial Embolism -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76957971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stroke&rft.atitle=Comparison+of+TNK+with+wild-type+tissue+plasminogen+activator+in+a+rabbit+embolic+stroke+model.&rft.au=Chapman%2C+D+F%3BLyden%2C+P%3BLapchak%2C+P+A%3BNunez%2C+S%3BThibodeaux%2C+H%3BZivin%2C+J&rft.aulast=Chapman&rft.aufirst=D&rft.date=2001-03-01&rft.volume=32&rft.issue=3&rft.spage=748&rft.isbn=&rft.btitle=&rft.title=Stroke&rft.issn=1524-4628&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-26 N1 - Date created - 2001-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thiamine treatment of chronic hepatitis B infection AN - 759322085; 13788146 AB - OBJECTIVE:Chronic hepatitis B is an international health concern that causes cirrhosis, hepatocellular carcinoma, liver failure, and death. Current treatment options are expensive and associated with side effects; however, indirect evidence suggests a relationship between relative thiamine deficiency and chronic hepatitis B infection. METHODS:The authors present three case studies wherein multiple crossovers of daily thiamine administration were used to evaluate a hypothesized association between thiamine treatment and aminotransferase levels. RESULTS:In each case study, thiamine administration was associated with reduction in aminotransferase levels and the fall of HBV DNA to undetectable levels. Analyses by t test demonstrated a statistically significant reduction in aminotransferase levels in all three cases. CONCLUSIONS:The relationship between thiamine administration and chronic hepatitis B infection warrants further study. If proven effective in reducing liver damage or inducing remission of the hepatitis B virus in larger trials, thiamine will offer obvious advantages over the current treatments for chronic viral hepatitis B infection.The American Journal of Gastroenterology (2001) 96, 864-868; doi:10.1111/j.1572-0241.2001.03635.x JF - American Journal of Gastroenterology AU - Wallace, Amy Elizabeth AU - Weeks, William Brinson AD - [1] 1 Department of Psychiatry, Dartmouth Medical School, Hanover, New Hampshire, USA [2] 3 Veterans Administration Medical Center, White River Junction, Vermont, USA Y1 - 2001/03// PY - 2001 DA - Mar 2001 SP - 864 EP - 868 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 96 IS - 3 SN - 0002-9270, 0002-9270 KW - Virology & AIDS Abstracts; Toxicology Abstracts KW - Liver diseases KW - Cirrhosis KW - Hepatitis B virus KW - Thiamine KW - Statistical analysis KW - Remission KW - Gastroenterology KW - Chronic infection KW - Hepatitis B KW - DNA KW - Side effects KW - Hepatocellular carcinoma KW - X 24310:Pharmaceuticals KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759322085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Gastroenterology&rft.atitle=Thiamine+treatment+of+chronic+hepatitis+B+infection&rft.au=Wallace%2C+Amy+Elizabeth%3BWeeks%2C+William+Brinson&rft.aulast=Wallace&rft.aufirst=Amy&rft.date=2001-03-01&rft.volume=96&rft.issue=3&rft.spage=864&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/10.1111%2Fj.1572-0241.2001.03635.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Cirrhosis; Liver diseases; Chronic infection; DNA; Statistical analysis; Hepatitis B; Thiamine; Remission; Side effects; Hepatocellular carcinoma; Gastroenterology; Hepatitis B virus DO - http://dx.doi.org/10.1111/j.1572-0241.2001.03635.x ER - TY - JOUR T1 - Site-directed mutagenesis of cation coordinating residues in the gastric H,K-ATPase. AN - 70859024; 11368180 AB - Site-mutations were introduced into putative cation binding site 1 of the H,K-ATPase at glu-797, thr-825, and glu-938. The side chain oxygen of each was not essential but the mutations produced different activation and inhibition kinetics. Site mutations thr-825 (ala, leu) and glu-938 (ala, gln) modestly decreased the apparent affinity to K+, while glu-797 (gln) was equivalent to wild type. As expected of competitive inhibition, mutations of thr-825 and glu-938 that decreased the apparent affinity for K+ also increased the apparent affinity for SCH28080. This is consistent with the participation of thr-825 and glu-938 in a cation binding domain. The sidechain geometry, but not the sidechain charge of glu-797, is essential to ATPase function as the site mutant glu-797 (gly) inactivated the H,K-ATPase, while glu-797 (gln) was active but the apparent affinity to SCH 28080 was decreased by four-fold. Lys-793, a unique residue of the H,K-ATPase, was essential for ATPase function. Since this residue is adjacent to site 1, the result suggests that charge pairing between lys-793 and residues at or near this site may be essential to ATPase function. JF - Archives of biochemistry and biophysics AU - Rulli, S J AU - Louneva, N M AU - Skripnikova, E V AU - Rabon, E C AD - Department of Physiology, Tulane University Medical Center and Veterans Administration Center, New Orleans, Louisiana 70112, USA. Y1 - 2001/03/01/ PY - 2001 DA - 2001 Mar 01 SP - 27 EP - 34 VL - 387 IS - 1 SN - 0003-9861, 0003-9861 KW - Cations KW - 0 KW - Membrane Proteins KW - Recombinant Proteins KW - H(+)-K(+)-Exchanging ATPase KW - EC 3.6.3.10 KW - Calcium-Transporting ATPases KW - EC 3.6.3.8 KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Animals KW - Calcium-Transporting ATPases -- chemistry KW - Rabbits KW - Membrane Proteins -- genetics KW - Proto-Oncogenes KW - Potassium -- metabolism KW - Cations -- metabolism KW - Mutagenesis, Site-Directed KW - Recombinant Proteins -- metabolism KW - Models, Chemical KW - Binding Sites -- genetics KW - Recombinant Proteins -- chemistry KW - Calcium-Transporting ATPases -- metabolism KW - H(+)-K(+)-Exchanging ATPase -- metabolism KW - H(+)-K(+)-Exchanging ATPase -- chemistry KW - H(+)-K(+)-Exchanging ATPase -- genetics KW - Stomach -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70859024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+biochemistry+and+biophysics&rft.atitle=Site-directed+mutagenesis+of+cation+coordinating+residues+in+the+gastric+H%2CK-ATPase.&rft.au=Rulli%2C+S+J%3BLouneva%2C+N+M%3BSkripnikova%2C+E+V%3BRabon%2C+E+C&rft.aulast=Rulli&rft.aufirst=S&rft.date=2001-03-01&rft.volume=387&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Archives+of+biochemistry+and+biophysics&rft.issn=00039861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-14 N1 - Date created - 2001-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intravenous cocaine increases plasma epinephrine and norepinephrine in humans. AN - 70779743; 11325399 AB - Cocaine has been shown to activate the sympathoadrenal system in both animal and human studies. Controlled human studies have found inconclusive results regarding whether acute cocaine treatment elevates plasma epinephrine and norepinephrine concentrations. The purpose of this study was to investigate whether commonly abused doses of cocaine increase plasma epinephrine and norepinephrine concentrations in humans, in a double-blind, placebo-controlled study. Five male cocaine users were given an intravenous injection of 0.46 mg/kg dose of cocaine or placebo, on two consecutive days. Plasma epinephrine and norepinephrine concentrations were significantly increased in response to cocaine injection compared to placebo. Peak plasma epinephrine and norepinephrine concentrations were reached 3 and 12 min after cocaine injection, respectively. While changes in epinephrine levels following cocaine were correlated with systolic blood pressure and heart rate changes, changes in plasma norepinephrine were correlated with diastolic blood pressure and heart rate changes following cocaine administration. These results suggest that plasma epinephrine and norepinephrine can be used as a measure for cocaine induced sympathoadrenal system activation. JF - Pharmacology, biochemistry, and behavior AU - Sofuoglu, M AU - Nelson, D AU - Babb, D A AU - Hatsukami, D K AD - Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA. mehmet.sofuoglu2@med.va.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 455 EP - 459 VL - 68 IS - 3 SN - 0091-3057, 0091-3057 KW - Dopamine Uptake Inhibitors KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Norepinephrine KW - X4W3ENH1CV KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - Heart Rate -- drug effects KW - Injections, Intravenous KW - Humans KW - Adult KW - Cocaine-Related Disorders -- physiopathology KW - Cocaine-Related Disorders -- blood KW - Blood Pressure -- drug effects KW - Male KW - Norepinephrine -- blood KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Cocaine -- pharmacology KW - Epinephrine -- blood KW - Cocaine -- administration & dosage KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70779743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Intravenous+cocaine+increases+plasma+epinephrine+and+norepinephrine+in+humans.&rft.au=Sofuoglu%2C+M%3BNelson%2C+D%3BBabb%2C+D+A%3BHatsukami%2C+D+K&rft.aulast=Sofuoglu&rft.aufirst=M&rft.date=2001-03-01&rft.volume=68&rft.issue=3&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-19 N1 - Date created - 2001-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Linezolid: an oxazolidinone antimicrobial agent. AN - 70777574; 11318073 AB - Linezolid is the first oxazolidinone anti-infective agent marketed in the United States. It is indicated for the treatment of nosocomial pneumonia, complicated skin and skin-structure infections caused by methicillin-sensitive or methicillin-resistant Staphylococcus aureus and other susceptible organisms, and vancomycin-resistant Enterococcus faecium infections. It also is indicated for the treatment of uncomplicated skin and skin-structure infections caused by methicillin-sensitive S. aureus or Streptococcus pyogenes, and community-acquired pneumonia caused by penicillin-sensitive Streptococcus pneumoniae. This article reviews the pharmacologic properties and clinical usefulness of linezolid. Using the terms linezolid, PNU-100766, and oxazolidinone, we performed a literature search of the following databases: MEDLINE (1966 to September 2000), HealthSTAR (1993 to September 2000), Iowa Drug Information Service (1966 to September 2000), International Pharmaceutical Abstracts (1970 to September 2000), PharmaProjects (January 2000 version), and meeting abstracts of the Infectious Diseases Society of America and the Interscience Conference on Antimicrobial Agents and Chemotherapy (1996 to 2000). Linezolid has a unique structure and mechanism of action, which targets protein synthesis at an exceedingly early stage. Consequently, cross-resistance with other commercially available antimicrobial agents is unlikely. It is primarily effective against gram-positive bacteria. To date, resistance to linezolid has been reported in patients infected with enterococci. The pharmacokinetic parameters of linezolid in adults are not altered by hepatic or renal function, age, or sex to an extent requiring dose adjustment. Linezolid is metabolized via morpholine ring oxidation, which is independent of the cytochrome P450 (CYP450) enzyme system; as a result, linezolid is unlikely to interact with medications that stimulate or inhibit CYP450 enzymes. Compassionate-use trials and other clinical studies involving mainly adult hospitalized patients with gram-positive infections have shown that linezolid administered intravenously or orally is effective in a variety of nosocomial and community-acquired infections, including those caused by resistant gram-positive organisms. Reported adverse effects include thrombocytopenia. diarrhea, headache, nausea, vomiting, insomnia, constipation, rash, and dizziness. Preliminary pharmacoeconomic data indicate that a significantly higher percentage of patients receiving linezolid therapy versus comparator could be discharged from the hospital by day 7 (P = 0.005). Linezolid appears to be effective while maintaining an acceptable tolerability profile. Due to the risk of bacterial resistance, linezolid should be reserved for the treatment of documented serious vancomycin-resistant enterococcal infections. JF - Clinical therapeutics AU - Fung, H B AU - Kirschenbaum, H L AU - Ojofeitimi, B O AD - Critical Care Center, Veterans Affairs Medical Center, Bronx, New York 10468, USA. horatio.fung@med.va.gov Y1 - 2001/03// PY - 2001 DA - March 2001 SP - 356 EP - 391 VL - 23 IS - 3 SN - 0149-2918, 0149-2918 KW - Acetamides KW - 0 KW - Anti-Bacterial Agents KW - Oxazolidinones KW - Linezolid KW - ISQ9I6J12J KW - Index Medicus KW - Soft Tissue Infections -- drug therapy KW - Animals KW - Drug Interactions KW - Pneumonia, Bacterial -- drug therapy KW - Humans KW - Cross Infection -- drug therapy KW - Vancomycin Resistance KW - Anti-Bacterial Agents -- therapeutic use KW - Acetamides -- pharmacology KW - Oxazolidinones -- therapeutic use KW - Oxazolidinones -- pharmacology KW - Acetamides -- therapeutic use KW - Acetamides -- pharmacokinetics KW - Oxazolidinones -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70777574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+therapeutics&rft.atitle=Linezolid%3A+an+oxazolidinone+antimicrobial+agent.&rft.au=Fung%2C+H+B%3BKirschenbaum%2C+H+L%3BOjofeitimi%2C+B+O&rft.aulast=Fung&rft.aufirst=H&rft.date=2001-03-01&rft.volume=23&rft.issue=3&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=Clinical+therapeutics&rft.issn=01492918&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-08-30 N1 - Date created - 2001-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Augmentation of Apoptosis and Interferon- gamma Production at Sites of Active Mycobacterium tuberculosis Infection in Human Tuberculosis AN - 18075268; 5149676 AB - Pleural tuberculosis (TB) was employed as a model to study T cell apoptosis at sites of active Mycobacterium tuberculosis (MTB) infection in human immunodeficiency virus (HIV)-coinfected (HIV/TB) patients and patients infected with TB alone. Apoptosis in blood and in pleural fluid mononuclear cells and cytokine immunoreactivities in plasma and in pleural fluid were evaluated. T cells were expanded at the site of MTB infection, irrespective of HIV status. Apoptosis of CD4 and non-CD4 T cells in the pleural space occurred in both HIV/TB and TB. Interferon (IFN)- gamma levels were increased in pleural fluid, compared with plasma. Spontaneous apoptosis correlated with specific loss of MTB-reactive, IFN- gamma -producing pleural T cells. Immunoreactivities of molecules potentially involved in apoptosis, such as tumor necrosis factor- alpha , Fas-ligand, and Fas, were increased in pleural fluid, compared with plasma. These data suggest that continued exposure of immunoreactive cells to MTB at sites of infection may initiate a vicious cycle in which immune activation and loss of antigen-responsive T cells occur concomitantly, thus favoring persistence of MTB infection. JF - Journal of Infectious Diseases AU - Hirsch, C S AU - Toossi, Z AU - Johnson, J L AU - Luzze, H AU - Ntambi, L AU - Peters, P AU - McHugh, M AU - Okwera, A AU - Joloba, M AU - Mugyenyi, P AU - Mugerwa, R D AU - Terebuh, P AU - Ellner, J J AD - Case Western Reserve University, University Hospitals of Cleveland, and Veterans Administration Medical Center, Cleveland, Ohio, USA Y1 - 2001/03/01/ PY - 2001 DA - 2001 Mar 01 SP - 779 EP - 788 VL - 183 IS - 5 SN - 0022-1899, 0022-1899 KW - man KW - HIV KW - CD4 antigen KW - gamma -Interferon KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - g-Interferon KW - Acquired immune deficiency syndrome KW - Apoptosis KW - ^g-Interferon KW - Human immunodeficiency virus KW - Lymphocytes T KW - Tuberculosis KW - Mycobacterium tuberculosis KW - F 06773:Interferons KW - F 06801:Bacteria KW - F 06737:Apoptosis KW - J 02833:Immune response and immune mechanisms KW - F 06756:Function KW - V 22003:AIDS: Immunological aspects KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18075268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Augmentation+of+Apoptosis+and+Interferon-+gamma+Production+at+Sites+of+Active+Mycobacterium+tuberculosis+Infection+in+Human+Tuberculosis&rft.au=Hirsch%2C+C+S%3BToossi%2C+Z%3BJohnson%2C+J+L%3BLuzze%2C+H%3BNtambi%2C+L%3BPeters%2C+P%3BMcHugh%2C+M%3BOkwera%2C+A%3BJoloba%2C+M%3BMugyenyi%2C+P%3BMugerwa%2C+R+D%3BTerebuh%2C+P%3BEllner%2C+J+J&rft.aulast=Hirsch&rft.aufirst=C&rft.date=2001-03-01&rft.volume=183&rft.issue=5&rft.spage=779&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus; Mycobacterium tuberculosis; Tuberculosis; Apoptosis; Lymphocytes T; Acquired immune deficiency syndrome; ^g-Interferon ER - TY - JOUR T1 - Mycobacterium tuberculosis Phagosomes Exhibit Altered Calmodulin-Dependent Signal Transduction: Contribution to Inhibition of Phagosome-Lysosome Fusion and Intracellular Survival in Human Macrophages AN - 17802483; 4849343 AB - Mycobacterium tuberculosis successfully parasitizes macrophages by disrupting the maturation of its phagosome, creating an intracellular compartment with endosomal rather than lysosomal characteristics. We have recently demonstrated that live M. tuberculosis infect human macrophages in the absence of an increase in cytosolic Ca super(2+) ([Ca super(2+)] sub(c)), which correlates with inhibition of phagosome-lysosome fusion and intracellular viability. In contrast, killed M. tuberculosis induces an elevation in [Ca super(2+)] sub(c) that is coupled to phagosome-lysosome fusion. We tested the hypothesis that defective activation of the Ca super(2+)-dependent effector proteins calmodulin (CaM) and CaM-dependent protein kinase II (CaMKII) contributes to the intracellular pathogenesis of tuberculosis. Phagosomes containing live M. tuberculosis exhibited decreased levels of CaM and the activated form of CaMKII compared with phagosomes encompassing killed tubercle bacilli. Furthermore, ionophore-induced elevations in [Ca super(2+)] sub(c) resulted in recruitment of CaM and activation of CaMKII on phagosomes containing live M. tuberculosis. Specific inhibitors of CaM or CaMKII blocked Ca super(2+) ionophore-induced phagosomal maturation and enhanced the bacilli's intracellular viability. These results demonstrate a novel role for CaM and CaMKII in the regulation of phagosome-lysosome fusion and suggest that defective activation of these Ca super(2+)-activated signaling components contributes to the successful parasitism of human macrophages by M. tuberculosis. JF - Journal of Immunology AU - Malik, Z A AU - Iyer, S S AU - Kusner, D J AD - Inflammation Program, Graduate Program in Immunology, and Department of Internal Medicine, University of Iowa and Veterans Administration Medical Center, Iowa City, IA 52242 Y1 - 2001/03/01/ PY - 2001 DA - 2001 Mar 01 SP - 3392 EP - 3401 VL - 166 IS - 5 SN - 0022-1767, 0022-1767 KW - immunology KW - Mycobacterium tuberculosis KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Calcium KW - Ca@@u2+@/calmodulin-dependent protein kinase II KW - Phagosomes KW - Calmodulin KW - Tuberculosis KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17802483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Mycobacterium+tuberculosis+Phagosomes+Exhibit+Altered+Calmodulin-Dependent+Signal+Transduction%3A+Contribution+to+Inhibition+of+Phagosome-Lysosome+Fusion+and+Intracellular+Survival+in+Human+Macrophages&rft.au=Malik%2C+Z+A%3BIyer%2C+S+S%3BKusner%2C+D+J&rft.aulast=Malik&rft.aufirst=Z&rft.date=2001-03-01&rft.volume=166&rft.issue=5&rft.spage=3392&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Phagosomes; Macrophages; Calcium; Calmodulin; Tuberculosis; Ca@@u2+@/calmodulin-dependent protein kinase II ER - TY - JOUR T1 - Results of targeted anti-tumor necrosis factor therapy with etanercept (ENBREL) in patients with advanced heart failure. AN - 70657048; 11222463 AB - Previously, we showed that tumor necrosis factor (TNF) antagonism with etanercept, a soluble TNF receptor, was well tolerated and that it suppressed circulating levels of biologically active TNF for 14 days in patients with moderate heart failure. However, the effects of sustained TNF antagonism in heart failure are not known. We conducted a randomized, double-blind, placebo-controlled, multidose trial of etanercept in 47 patients with NYHA class III to IV heart failure. Patients were treated with biweekly subcutaneous injections of etanercept 5 mg/m(2) (n=16) or 12 mg/m(2) (n=15) or with placebo (n=16) for 3 months. Doses of 5 and 12 mg/m(2) etanercept were safe and well tolerated for 3 months. Treatment with etanercept led to a significant dose-dependent improvement in left ventricular (LV) ejection fraction and LV remodeling, and there was a trend toward an improvement in patient functional status, as determined by clinical composite score. Treatment with etanercept for 3 months was safe and well-tolerated in patients with advanced heart failure, and it resulted in a significant dose-dependent improvement in LV structure and function and a trend toward improvement in patient functional status. JF - Circulation AU - Bozkurt, B AU - Torre-Amione, G AU - Warren, M S AU - Whitmore, J AU - Soran, O Z AU - Feldman, A M AU - Mann, D L AD - Winters Center For Heart Failure Research, Department of Medicine, Veterans Administration Medical Center, Houston, TX 77030, USA. Y1 - 2001/02/27/ PY - 2001 DA - 2001 Feb 27 SP - 1044 EP - 1047 VL - 103 IS - 8 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Immunoglobulin G KW - Receptors, Tumor Necrosis Factor KW - Tumor Necrosis Factor-alpha KW - Etanercept KW - OP401G7OJC KW - Index Medicus KW - Ventricular Function, Left -- drug effects KW - Double-Blind Method KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Humans KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Cohort Studies KW - Treatment Outcome KW - Myocardial Contraction -- drug effects KW - Middle Aged KW - Male KW - Female KW - Heart Diseases -- drug therapy KW - Immunoglobulin G -- adverse effects KW - Receptors, Tumor Necrosis Factor -- therapeutic use KW - Tumor Necrosis Factor-alpha -- antagonists & inhibitors KW - Tumor Necrosis Factor-alpha -- metabolism KW - Immunoglobulin G -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70657048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation&rft.atitle=Results+of+targeted+anti-tumor+necrosis+factor+therapy+with+etanercept+%28ENBREL%29+in+patients+with+advanced+heart+failure.&rft.au=Bozkurt%2C+B%3BTorre-Amione%2C+G%3BWarren%2C+M+S%3BWhitmore%2C+J%3BSoran%2C+O+Z%3BFeldman%2C+A+M%3BMann%2C+D+L&rft.aulast=Bozkurt&rft.aufirst=B&rft.date=2001-02-27&rft.volume=103&rft.issue=8&rft.spage=1044&rft.isbn=&rft.btitle=&rft.title=Circulation&rft.issn=1524-4539&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-14 N1 - Date created - 2001-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Construction of Acetate Auxotrophs of Neisseria meningitidis to Study Host-Meningococcal Endotoxin Interactions AN - 17806208; 4844949 AB - To facilitate studies of the molecular determinants of host-meningococcal lipooligosaccharide (endotoxin) interactions at patho-physiologically relevant endotoxin concentrations (i.e. <=10 ng/ml), we have generated acetate auxotrophs NMBACE1 from encapsulated Neisseria meningitidis (serogroup B, strain NMB) and NMBACE2 from an isogenic bacterial mutant lacking the polysialic acid capsule. Growth of the auxotrophs in medium containing [ super(14)C]acetate yielded super(14)C-lipooligosaccharides containing similar to 600 cpm/ng. Gel sieving resolved super( 14)C-lipooligosaccharide-containing aggregates with an estimated molecular mass of greater than or equal to 20 x 10 super(6) Da (peak A) and similar to 1 x 10 super(6) Da (peak B) from both strains. Lipooligosaccharides in peaks A and B had the same fatty acid composition and SDS-polyacrylamide gel electrophoresis profile. super(14)C-Labeled capsule copurified with super(14)C-lipooligosaccharides in peak B from NMBACE1, whereas the other aggregates contained only super(14)C-lipooligosaccharide. For all aggregates, lipopolysaccharide-binding protein and soluble CD14-induced delivery of lipooligosaccharides to endothelial cells and cell activation correlated with disaggregation of lipooligosaccharides. These processes were inhibited by the presence of capsule but unaffected by the size of the aggregates. In contrast, endotoxin activation of cells containing membrane CD14 was unaffected by capsule but diminished when endotoxin was presented in larger aggregates. These findings demonstrate that the physical presentation of lipooligosaccharide, including possible interactions with capsule, affect the ability of meningococcal endotoxin to interact with and activate specific host targets. JF - Journal of Biological Chemistry AU - Giardina, P C AU - Gioannini, T AU - Buscher, BA AU - Zaleski, A AU - Zheng, D S AU - Stoll, L AU - Teghanemt, A AU - Apicella, MA AU - Weiss, J AD - Departments of Microbiology, Biochemistry, and Medicine, Division of Infectious Diseases, The Inflammation Program, University of Iowa and Veterans' Administration Medical Center, Iowa City, Iowa 52242, jerrold-weiss@uiowa.edu Y1 - 2001/02/23/ PY - 2001 DA - 2001 Feb 23 SP - 5883 EP - 5891 VL - 276 IS - 8 SN - 0021-9258, 0021-9258 KW - lipooligosaccharides KW - Microbiology Abstracts B: Bacteriology KW - Endotoxins KW - Auxotrophs KW - Neisseria meningitidis KW - Acetic acid KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17806208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Construction+of+Acetate+Auxotrophs+of+Neisseria+meningitidis+to+Study+Host-Meningococcal+Endotoxin+Interactions&rft.au=Giardina%2C+P+C%3BGioannini%2C+T%3BBuscher%2C+BA%3BZaleski%2C+A%3BZheng%2C+D+S%3BStoll%2C+L%3BTeghanemt%2C+A%3BApicella%2C+MA%3BWeiss%2C+J&rft.aulast=Giardina&rft.aufirst=P&rft.date=2001-02-23&rft.volume=276&rft.issue=8&rft.spage=5883&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Neisseria meningitidis; Endotoxins; Auxotrophs; Acetic acid ER - TY - JOUR T1 - Unexpected Similarity of Pulsed-Field Gel Electrophoresis Patterns of Unrelated Clinical Isolates of Legionella pneumophila, Serogrop 1 AN - 18075336; 5149699 AB - Phenotypic and genotypic methods identify subtypes of Legionella pneumophila, serogroup 1, and match patient and environmental isolates from suspected sources. The strength of this association is limited by the lack of information regarding the frequency and distribution of isolates belonging to various subtypes. In this study, 62 clinical isolates of L. pneumophila, serogroup 1, were subtyped by using pulsed-field gel electrophoresis (PFGE), to determine the distribution and degree of diversity of PFGE patterns among monoclonal antibody (MAb) subtypes. Unexpectedly, 8 of 21 MAb Philadelphia 1 isolates had a common PFGE pattern, and, among 12 MAb OLDA isolates, only 2 PFGE patterns were seen. Our hypothesis was that PFGE patterns were distributed randomly; however, statistical analysis showed that the distribution of subtypes was not random (Fisher's exact test 0.13; P > .05). In light of these results, researchers who do epidemiological investigations should use caution when interpreting the significance of matching PFGE patterns of L. pneumophila, serogroup 1. JF - Journal of Infectious Diseases AU - Drenning, S D AU - Stout, JE AU - Joly, J R AU - Yu, V L AD - Department of Medicine, University of Pittsburgh School of Medicine, and Veterans Administration Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA Y1 - 2001/02/15/ PY - 2001 DA - 2001 Feb 15 SP - 628 EP - 632 VL - 183 IS - 4 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology KW - Serological surveys KW - Legionella pneumophila KW - Genetic variance KW - Typing KW - Monoclonal antibodies KW - Nucleotide sequence KW - Pulsed-field gel electrophoresis KW - J 02710:Identification, taxonomy and typing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18075336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Unexpected+Similarity+of+Pulsed-Field+Gel+Electrophoresis+Patterns+of+Unrelated+Clinical+Isolates+of+Legionella+pneumophila%2C+Serogrop+1&rft.au=Drenning%2C+S+D%3BStout%2C+JE%3BJoly%2C+J+R%3BYu%2C+V+L&rft.aulast=Drenning&rft.aufirst=S&rft.date=2001-02-15&rft.volume=183&rft.issue=4&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Legionella pneumophila; Pulsed-field gel electrophoresis; Typing; Genetic variance; Nucleotide sequence; Monoclonal antibodies; Serological surveys ER - TY - JOUR T1 - Examination of the neighborhood activation theory in normal and hearing-impaired listeners. AN - 85357459; pmid-11271971 AB - Experiments were conducted to examine the effects of lexical information on word recognition among normal hearing listeners and individuals with sensorineural hearing loss. The lexical factors of interest were incorporated in the Neighborhood Activation Model (NAM). Central to this model is the concept that words are recognized relationally in the context of other phonemically similar words. NAM suggests that words in the mental lexicon are organized into similarity neighborhoods and the listener is required to select the target word from competing lexical items. Two structural characteristics of similarity neighborhoods that influence word recognition have been identified; "neighborhood density" or the number of phonemically similar words (neighbors) for a particular target item and "neighborhood frequency" or the average frequency of occurrence of all the items within a neighborhood. A third lexical factor, "word frequency" or the frequency of occurrence of a target word in the language, is assumed to optimize the word recognition process by biasing the system toward choosing a high frequency over a low frequency word.Three experiments were performed. In the initial experiments, word recognition for consonant-vowel-consonant (CVC) monosyllables was assessed in young normal hearing listeners by systematically partitioning the items into the eight possible lexical conditions that could be created by two levels of the three lexical factors, word frequency (high and low), neighborhood density (high and low), and average neighborhood frequency (high and low). Neighborhood structure and word frequency were estimated computationally using a large, on-line lexicon-based Webster's Pocket Dictionary. From this program 400 highly familiar, monosyllables were selected and partitioned into eight orthogonal lexical groups (50 words/group). The 400 words were presented randomly to normal hearing listeners in speech-shaped noise (Experiment 1) and "in quiet" (Experiment 2) as well as to an elderly group of listeners with sensorineural hearing loss in the speech-shaped noise (Experiment 3).The results of three experiments verified predictions of NAM in both normal hearing and hearing-impaired listeners. In each experiment, words from low density neighborhoods were recognized more accurately than those from high density neighborhoods. The presence of high frequency neighbors (average neighborhood frequency) produced poorer recognition performance than comparable conditions with low frequency neighbors. Word frequency was found to have a highly significant effect on word recognition. Lexical conditions with high word frequencies produced higher performance scores than conditions with low frequency words.The results supported the basic tenets of NAM theory and identified both neighborhood structural properties and word frequency as significant lexical factors affecting word recognition when listening in noise and "in quiet." The results of the third experiment permit extension of NAM theory to individuals with sensorineural hearing loss. Future development of speech recognition tests should allow for the effects of higher level cognitive (lexical) factors on lower level phonemic processing. JF - Ear and hearing AU - Dirks, D D AU - Takayanagi, S AU - Moshfegh, A AU - Noffsinger, P D AU - Fausti, S A AD - National Center for Rehabilitative Auditory Research, Veterans Administration Medical Center, Portland, Oregon, USA. Y1 - 2001/02// PY - 2001 DA - Feb 2001 SP - 1 EP - 13 VL - 22 IS - 1 SN - 0196-0202, 0196-0202 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Aged, 80 and over KW - Female KW - *Hearing Loss, Sensorineural: diagnosis KW - Humans KW - Male KW - Middle Aged KW - Phonetics KW - Severity of Illness Index KW - *Speech Perception: physiology KW - Vocabulary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85357459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear+and+hearing&rft.atitle=Examination+of+the+neighborhood+activation+theory+in+normal+and+hearing-impaired+listeners.&rft.au=Dirks%2C+D+D%3BTakayanagi%2C+S%3BMoshfegh%2C+A%3BNoffsinger%2C+P+D%3BFausti%2C+S+A&rft.aulast=Dirks&rft.aufirst=D&rft.date=2001-02-01&rft.volume=22&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Ear+and+hearing&rft.issn=01960202&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Interpretation of Fables and Proverbs by African Americans With and Without Aphasia AN - 85301931; cs-286963 AB - There is a paucity of performance information for African American adults with aphasia on appraisal tasks, especially in comparison with performance by neurologically normal African American adults. We administered language impairment, functional communication, and discourse measures to neurologically normal African American adults and African American adults with aphasia. The neurologically normal group performed significantly better on the language impairment measure (Western Aphasia Battery), the functional communication measure (ASHA Functional Assessment of Communication Skills for Adults), providing the lesson in a fable discourse task, and spontaneous interpretation of proverbs. No significant differences between groups were observed on a picture description fable task or in performance on a multiple-choice proverb task. Few significant relationships were observed among measures in the neurologically normal group; however, the group with aphasia displayed a variety of significant relationships in their performance on the language impairment, functional communication, fable lesson, and interpretation of proverbs tasks. The results imply that fable and proverb discourse tasks may be valuable supplemental measures for characterizing communicative competence in African American adults who have aphasia. JF - American Journal of Speech-Language Pathology AU - Ulatowska, Hanna K AU - Wertz, Robert Terrence AU - Chapman, Sandra Bond AU - Hill, CaSaundra L AU - Thompson, Jennifer L AU - Keebler, Molly W AU - Olness, Gloria Streit AU - Parsons, Sharon D AU - Miller, Teya AU - Auther, Linda L AD - Program in Communication Disorders, School of Behavioral and Brain Sciences, University of Texas at Dallas; Department of Hearing and Speech Sciences, Bill Wilkerson Center for Otolaryngology and Communication Sciences, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Vanderbilt University; Psychology, School of Behavioral and Brain Sciences, University of Texas at Dallas; Callier Center for Communication Disorders, University of Texas at Dallas; Baylor University Medical Center, Dallas, TX; Parkland Health and Hospital System, Dallas, TX; Evanston NW Healthcare, Chicago, IL; Veterans Administration Medical Center, Nashville, TN PY - 2001 SP - 40 EP - 50 VL - 10 IS - 1 SN - 1058-0360, 1058-0360 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85301931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Speech-Language+Pathology&rft.atitle=Interpretation+of+Fables+and+Proverbs+by+African+Americans+With+and+Without+Aphasia&rft.au=Ulatowska%2C+Hanna+K%3BWertz%2C+Robert+Terrence%3BChapman%2C+Sandra+Bond%3BHill%2C+CaSaundra+L%3BThompson%2C+Jennifer+L%3BKeebler%2C+Molly+W%3BOlness%2C+Gloria+Streit%3BParsons%2C+Sharon+D%3BMiller%2C+Teya%3BAuther%2C+Linda+L&rft.aulast=Ulatowska&rft.aufirst=Hanna&rft.date=2001-02-01&rft.volume=10&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Speech-Language+Pathology&rft.issn=10580360&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The functional anatomy of gaze-evoked tinnitus and sustained lateral gaze. AN - 85169278; pmid-11222790 AB - OBJECTIVE: To identify neural sites associated with gaze-evoked tinnitus (GET), an unusual condition that may follow cerebellar-pontine angle surgery. METHODS: The authors examined eight patients with GET and used PET to map the neural sites activated by lateral gaze in them and seven age- and sex-matched control subjects. RESULTS: In patients with GET, tinnitus loudness and pitch increased with lateral gaze and, to a lesser extent, up and down gaze. Evidence for neural activity related to GET was seen in the auditory lateral pontine tegmentum or auditory cortex. GET-associated nystagmus appears to activate the cuneus and cerebellar vermis. These sites were found in addition to an extensive network that included frontal eye fields and other sites in frontal, parietal, and temporal cortex that were activated by lateral gaze in seven control subjects and the patients. The unilateral deafness in patients with GET was associated with expansion of auditory cortical areas responsive to tones delivered to the good ear. In addition to GET, unilateral deafness, end-gaze nystagmus, and facial nerve dysfunction were common. CONCLUSIONS: Patients with GET have plastic changes in multiple neural systems that allow neural activity associated with eye movement, including those associated with the neural integrator, to stimulate the auditory system. Anomalous auditory activation is enhanced by the failure of cross-modal inhibition to suppress auditory cortical activity. The time course for the development of GET suggests that it may be due to multiple mechanisms. JF - Neurology AU - Lockwood, A H AU - Wack, D S AU - Burkard, R F AU - Coad, M L AU - Reyes, S A AU - Arnold, S A AU - Salvi, Richard J AD - Centers for Positron Emission Tomography, Veterans Administration Western New York Health Care System, Buffalo 14215, USA.; Department of Communicative Disorders and Sciences, College of Arts and Sciences, State University of New York at Buffalo PY - 2001 SP - 472 EP - 480 VL - 56 IS - 4 SN - 0028-3878, 0028-3878 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85169278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=The+functional+anatomy+of+gaze-evoked+tinnitus+and+sustained+lateral+gaze.&rft.au=Lockwood%2C+A+H%3BWack%2C+D+S%3BBurkard%2C+R+F%3BCoad%2C+M+L%3BReyes%2C+S+A%3BArnold%2C+S+A%3BSalvi%2C+Richard+J&rft.aulast=Lockwood&rft.aufirst=A&rft.date=2001-02-01&rft.volume=56&rft.issue=4&rft.spage=472&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Structure-activity relationships for the hypertensinogenic activity of ouabain: role of the sugar and lactone ring. AN - 76979857; 11230321 AB - Elevated levels of an endogenous ouabain circulate in many patients with essential hypertension. However, in contrast to ouabain, digoxin does not induce hypertension. This study investigated the hypothesis that within a single cardiac glycoside, the structural elements that induce hypertension differ from those responsible for high potency as a sodium pump inhibitor. Normal male Sprague-Dawley rats received infusions of vehicle (VEH), rhamnose (RHA), ouabain (OUA), ouabagenin (OGN), dihydro-ouabain (DHO), iso-ouabain (ISO), and a lactone ring opened analog (ORO) at 30 microgram. kg(-1). 24 h(-1) for 5 weeks via subcutaneous osmotic pumps. Cuff pressures were taken weekly. At the end of the study, trunk blood was harvested, extracted by C18 column, and subjected to high-performance liquid chromatography. Fractions were analyzed for OUA, OGN, and DHO by immunoassay. In OUA-, OGN-, and DHO-infused rats, 1 main peak of immunoreactivity corresponding to the infused agent was found. No evidence of in vivo conversion to OUA or DHO was found for any analog except ORO. At 5 weeks, systolic blood pressures in VEH, RHA, OUA, OGN, DHO, ISO, and ORO were 132+/-2.5, 133+/-1.5, 159+/-2.6,* 154+/-4,* 167+/-4,* 171+/-2.2,* and 169+/-2.4* mm Hg, respectively (*P<0.01 versus VEH and RHA, P<0.05 versus OUA). The hypertensinogenic activity was greater than OUA in 3 analogs (DHO, ISO, and ORO) in which the lactone was saturated, conformationally restrained by linkage with the oxygen at C14, or opened, respectively. These compounds were weak inhibitors of dog kidney Na,K-ATPase. Thus, RHA and the unsaturated lactone ring are crucial to the high potency of OUA as an inhibitor of the sodium pump but appear to be unrelated to its ability to induce hypertension. The conclusion that this form of hypertension is mediated primarily by the steroid nucleus suggests also that OUA may have a mechanism of action independent of the sodium pump. JF - Hypertension (Dallas, Tex. : 1979) AU - Manunta, P AU - Hamilton, B P AU - Hamlyn, J M AD - Departments of Physiology and Medicine, School of Medicine, University of Maryland, and the Veterans Administration Medical Center, Baltimore, Md, USA. Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 472 EP - 477 VL - 37 IS - 2 Pt 2 KW - Cardiac Glycosides KW - 0 KW - Enzyme Inhibitors KW - Lactones KW - Steroids KW - Ouabain KW - 5ACL011P69 KW - Sodium-Potassium-Exchanging ATPase KW - EC 3.6.3.9 KW - Rhamnose KW - QN34XC755A KW - Index Medicus KW - Animals KW - Infusions, Intravenous KW - Spectrophotometry, Ultraviolet KW - Rhamnose -- chemistry KW - Chromatography, High Pressure Liquid KW - Structure-Activity Relationship KW - Magnetic Resonance Spectroscopy KW - Rats KW - Rats, Sprague-Dawley KW - Steroids -- blood KW - Lactones -- chemistry KW - Enzyme Inhibitors -- pharmacology KW - Steroids -- chemistry KW - Blood Pressure -- drug effects KW - Male KW - Sodium-Potassium-Exchanging ATPase -- antagonists & inhibitors KW - Hypertension -- chemically induced KW - Hypertension -- blood KW - Ouabain -- chemistry KW - Cardiac Glycosides -- toxicity KW - Cardiac Glycosides -- pharmacology KW - Ouabain -- toxicity KW - Cardiac Glycosides -- chemistry KW - Ouabain -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76979857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Structure-activity+relationships+for+the+hypertensinogenic+activity+of+ouabain%3A+role+of+the+sugar+and+lactone+ring.&rft.au=Manunta%2C+P%3BHamilton%2C+B+P%3BHamlyn%2C+J+M&rft.aulast=Manunta&rft.aufirst=P&rft.date=2001-02-01&rft.volume=37&rft.issue=2+Pt+2&rft.spage=472&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=1524-4563&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-26 N1 - Date created - 2001-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Military and civilian penetrating eye trauma: anesthetic implications. AN - 72337184; 11759136 AB - In 20th century warfare, wounds from fragmentation weapons have become the number 1 cause of military hospital admissions during combat. Specifically, grenades, landmines, mortars, and artillery weapons have replaced guns and bullets. Consequently, penetrating eye injuries and maxillofacial injuries in the military have escalated dramatically. In the civilian sector, pipe bombs, explosive bottles used in gang warfare, and terrorist bombs, which are all fragmentation weapons, have generated new studies in the care of patients with penetrating eye injury. This change in the wounding pattern is, documented internationally in military-medical literature and in civilian-medical literature of relief agencies such as the International Committee of the Red Cross and the Red Crescent. The anesthetic management of open eye injuries has been a running controversy for 40 years in terms of the use of muscle relaxants. Nondepolarizing agents carry the risk of aspiration and increased intraocular pressure when trauma patients are intubated prematurely during rapid-sequence induction for "full stomachs." Succinylcholine would be the logical relaxant of choice for a rapid-sequence induction, but succinylcholine raises intraocular pressure. In many cases, the literature specifically contraindicates succinylcholine in the open eye injury for fear of extruding the content of the eye. A review of the vital assessment for the patient with a penetrating eye injury, as well as a comparative analysis of the literature, is presented. The conclusion favors pretreatment with a nondepolarizing agent and the use of succinylcholine during rapid-sequence induction. The eye injury itself is not the primary concern of this article. The primary concern is that open eye injuries serve as hallmarks for for more dangerous injuries. Penetrating open eye injuries merit extensive clinical assessment that can be life saving. JF - AANA journal AU - Biehl, J W AD - Veterans Administration Medical Center, Baltimore, Md., USA. Y1 - 2001/02// PY - 2001 DA - February 2001 SP - 31 EP - 37 VL - 69 IS - 1 SN - 0094-6354, 0094-6354 KW - Neuromuscular Depolarizing Agents KW - 0 KW - Succinylcholine KW - J2R869A8YF KW - Nursing KW - Neuromuscular Depolarizing Agents -- therapeutic use KW - Neuromuscular Depolarizing Agents -- adverse effects KW - Humans KW - Succinylcholine -- therapeutic use KW - Decision Making KW - Succinylcholine -- adverse effects KW - Blast Injuries -- surgery KW - Anesthesia -- methods KW - Wounds, Penetrating -- surgery KW - Eye Injuries -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72337184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AANA+journal&rft.atitle=Military+and+civilian+penetrating+eye+trauma%3A+anesthetic+implications.&rft.au=Biehl%2C+J+W&rft.aulast=Biehl&rft.aufirst=J&rft.date=2001-02-01&rft.volume=69&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=AANA+journal&rft.issn=00946354&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-08 N1 - Date created - 2001-12-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of atorvastatin 15 mg/week on serum lipids in patients with hypercholesterolemia. AN - 70594588; 11165974 AB - Atorvastatin 15 mg/week was administered to 21 patients with hypercholesterolemia for 2 months. The mean low-density lipoprotein concentration decreased by 20% after treatment. JF - The American journal of cardiology AU - Rindone, J P AU - Dzurick, J AU - Hiller, D AU - Peralta, B AD - Veterans Affairs Medical Center, Prescott, Arizona 86313, USA. joseph.rindone@med.va.gov Y1 - 2001/02/01/ PY - 2001 DA - 2001 Feb 01 SP - 341 EP - 2, A9 VL - 87 IS - 3 SN - 0002-9149, 0002-9149 KW - Heptanoic Acids KW - 0 KW - Lipids KW - Pyrroles KW - Atorvastatin Calcium KW - 48A5M73Z4Q KW - Cholesterol KW - 97C5T2UQ7J KW - Abridged Index Medicus KW - Index Medicus KW - Coronary Disease -- drug therapy KW - Cholesterol -- blood KW - Drug Administration Schedule KW - Coronary Disease -- blood KW - Dose-Response Relationship, Drug KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Female KW - Pyrroles -- adverse effects KW - Lipids -- blood KW - Pyrroles -- administration & dosage KW - Hypercholesterolemia -- blood KW - Heptanoic Acids -- administration & dosage KW - Hypercholesterolemia -- drug therapy KW - Heptanoic Acids -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70594588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Effect+of+atorvastatin+15+mg%2Fweek+on+serum+lipids+in+patients+with+hypercholesterolemia.&rft.au=Rindone%2C+J+P%3BDzurick%2C+J%3BHiller%2C+D%3BPeralta%2C+B&rft.aulast=Rindone&rft.aufirst=J&rft.date=2001-02-01&rft.volume=87&rft.issue=3&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-22 N1 - Date created - 2001-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of tuberculosis (TB) on HIV-1 activity in dually infected patients AN - 18248969; 5306930 AB - Active TB in HIV-1-infected subjects is associated with increased HIV-1-related immunodeficiency and mortality. We assessed plasma viral load in HIV-1-infected patients with pulmonary TB (HIV/TB) and non-TB symptomatic HIV-1-infected patients (HIV). HIV-1 load was higher in HIV/TB compared with HIV at higher CD4 counts (> 500 / mu l) (P 900 / mu l to < 200/ mu l). HIV-1 RNA in serum and PBMC correlated to one another, and both were markedly higher in HIV/TB compared with HIV/C with higher CD4 counts. Also, during a longitudinal study of anti-tuberculous chemoprophylaxis in HIV-1-infected patients, 10 subjects who developed TB had serologies before, at the time, and after the diagnosis of TB. These HIV/TB patients had an increase in viral load (average 2.5-fold) at the time of diagnosis of TB (P < 0.05). Overall, these data indicate that the transcriptional activity of HIV-1 is enhanced in HIV-1-infected patients with active TB, especially during early HIV-1 disease. As TB often is an early HIV-1 opportunistic infection, it may particularly favour early viral replication and dissemination, and therefore contribute to progression of HIV-1 disease. JF - Clinical and Experimental Immunology AU - Toossi, Z AU - Mayanja-Kizza, H AU - Hirsch, C S AU - Edmonds, K L AU - Spahlinger, T AU - Hom, D L AU - Aung, H AU - Mugyenyi, P AU - Ellner, J J AU - Whalen, C W AD - Department of Medicine, Case Western Reserve University and Veterans Administration Medical Center, Cleveland, OH, USA, zxt2@po.cwru.edu Y1 - 2001/02// PY - 2001 DA - Feb 2001 SP - 233 EP - 238 PB - Blackwell Science Ltd VL - 123 IS - 2 SN - 0009-9104, 0009-9104 KW - man KW - HIV-1 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Acquired immune deficiency syndrome KW - Opportunist infection KW - RNA KW - Human immunodeficiency virus 1 KW - Polymerase chain reaction KW - Tuberculosis KW - Mixed infection KW - Mycobacterium tuberculosis KW - F 06801:Bacteria KW - J 02845:Ear, nose and respiratory tract KW - F 06860:CMI KW - F 06800:Viruses KW - V 22004:AIDS: Clinical aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18248969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Experimental+Immunology&rft.atitle=Impact+of+tuberculosis+%28TB%29+on+HIV-1+activity+in+dually+infected+patients&rft.au=Toossi%2C+Z%3BMayanja-Kizza%2C+H%3BHirsch%2C+C+S%3BEdmonds%2C+K+L%3BSpahlinger%2C+T%3BHom%2C+D+L%3BAung%2C+H%3BMugyenyi%2C+P%3BEllner%2C+J+J%3BWhalen%2C+C+W&rft.aulast=Toossi&rft.aufirst=Z&rft.date=2001-02-01&rft.volume=123&rft.issue=2&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Experimental+Immunology&rft.issn=00099104&rft_id=info:doi/10.1046%2Fj.1365-2249.2001.01401.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Human immunodeficiency virus 1; Acquired immune deficiency syndrome; Tuberculosis; Mixed infection; Polymerase chain reaction; RNA; Opportunist infection DO - http://dx.doi.org/10.1046/j.1365-2249.2001.01401.x ER - TY - JOUR T1 - Development of an exercise expert system for older adults AN - 18143020; 5125917 AB - The purpose of this study was to develop a computerized exercise expert system (CEES) that creates tailored exercise plans for older adults. A panel of experts was selected in the areas of medicine, exercise physiology, health promotion, exercise psychology, and gerontology. The experts communicated with the principal investigator and the project members by mail, email, telephone, and expert meetings. A two-day workshop was held during the second year for the project members as well as local and national experts to review the CEES. The CEES demonstrated adequate inter-rater reliability (0.80) and criterion validity (0.70). Content validity was achieved by literature review and expert opinion. The CEES gathers information on the elder's health status, clinical factors, and exercise determinants that characterize specific barriers or incentives to exercise. The software program then develops individualized exercise prescriptions that are customized to older adults. JF - Journal of Rehabilitation Research and Development AU - Boyette, L W AU - Lloyd, A AU - Manuel, S AU - Boyette, JE AU - Echt, K V AD - Atlanta Veterans Affairs Medical Center, Rehabilitation Research and Development Center (151R), 1670 Clairmont Road, Decatur, GA 30033, USA, boyette.lisa_@atlanta.va.gov Y1 - 2001/02// PY - 2001 DA - Feb 2001 SP - 79 EP - 91 VL - 38 IS - 1 SN - 0007-506X, 0007-506X KW - Physical Education Index KW - Development KW - Adults KW - Exercise KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18143020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Development+of+an+exercise+expert+system+for+older+adults&rft.au=Boyette%2C+L+W%3BLloyd%2C+A%3BManuel%2C+S%3BBoyette%2C+JE%3BEcht%2C+K+V&rft.aulast=Boyette&rft.aufirst=L&rft.date=2001-02-01&rft.volume=38&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=0007506X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Exercise; Adults; Development ER - TY - JOUR T1 - An increase in expression of a Mycobacterium tuberculosis mycolyl transferase gene (fbpB) occurs early after infection of human monocytes AN - 17883680; 5122101 AB - Changes in the mRNA levels of two Mycobacterium tuberculosis genes (fbpB known as antigen 85B, and hspX known as Acr) were studied in infected human monocytes. Antigen 85B is an enzyme involved in cell wall biosynthesis and is also a major target of the immune response. Acr is a stress protein believed to be involved in the bacillary response to adverse conditions and in non-replicating persistence. During the first 24 h of intracellular infection, the intramonocyte 85B mRNA level increased 54-fold (P = 0.00001) and 14.6 times in comparison with the 16S ribosomal rRNA. In contrast, the Acr mRNA fell 14.3 times. Although monocyte cytokine production was very variable, the 24 h secretion of tumour necrosis factor (TNF)- alpha correlated with the 85B-16S RNA ratio at 24 h (r = 0.77, P < 0.01). Furthermore, the addition of exogenous TNF- alpha to cultures was associated with a twofold increase in the 85B-16S ratio and, conversely, neutralization of endogenous TNF- alpha reduced the ratio. As antigen 85B also induces TNF- alpha , the positive feedback implied by our findings suggests a previously unsuspected role for this protein in the immunopathogenesis of tuberculosis. JF - Molecular Microbiology AU - Wilkinson, R J AU - Desjardin, LE AU - Islam, N AU - Gibson, B M AU - Kanost, R A AU - Wilkinson, KA AU - Poelman, D AU - Eisenach, K D AU - Toossi, Z AD - Division of Infectious Diseases, Case Western Reserve University, Biomedical Research Building, 10900 Euclid Avenue, Cleveland, OH 44106-4984, USA.~ Medical Research Service, J. L. McClellan Memorial Veterans' Administration Hospital, 4300 West 7th St., Little Rock, AR 72205, USA.~ Wellcome Centre for Clinical Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow HA1 3UJ, UK. Y1 - 2001/02// PY - 2001 DA - Feb 2001 SP - 813 EP - 821 PB - Blackwell Science Ltd VL - 39 IS - 3 SN - 0950-382X, 0950-382X KW - Acr gene KW - antigen 85B KW - mycolyl transferase KW - Microbiology Abstracts B: Bacteriology KW - Tumor necrosis factor-^a KW - Tuberculosis KW - Monocytes KW - rRNA 16S KW - Mycobacterium tuberculosis KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17883680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=An+increase+in+expression+of+a+Mycobacterium+tuberculosis+mycolyl+transferase+gene+%28fbpB%29+occurs+early+after+infection+of+human+monocytes&rft.au=Wilkinson%2C+R+J%3BDesjardin%2C+LE%3BIslam%2C+N%3BGibson%2C+B+M%3BKanost%2C+R+A%3BWilkinson%2C+KA%3BPoelman%2C+D%3BEisenach%2C+K+D%3BToossi%2C+Z&rft.aulast=Wilkinson&rft.aufirst=R&rft.date=2001-02-01&rft.volume=39&rft.issue=3&rft.spage=813&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; rRNA 16S; Tuberculosis; Tumor necrosis factor-^a; Monocytes ER - TY - JOUR T1 - Toleration of high doses of angiotensin-converting enzyme inhibitors in patients with chronic heart failure: results from the ATLAS trial. The Assessment of Treatment with Lisinopril and Survival. AN - 70592910; 11176729 AB - Treatment with angiotensin-converting enzyme (ACE) inhibitors reduces mortality and morbidity in patients with chronic heart failure (CHF), but most affected patients are not receiving these agents or are being treated with doses lower than those found to be efficacious in trials, primarily because of concerns about the safety and tolerability of these agents, especially at the recommended doses. The present study examines the safety and tolerability of high- compared with low-dose lisinopril in CHF. The Assessment of Lisinopril and Survival study was a multicenter, randomized, double-blind trial in which patients with or without previous ACE inhibitor treatment were stabilized receiving medium-dose lisinopril (12.5 or 15.0 mg once daily [OD]) for 2 to 4 weeks and then randomized to high- (35.0 or 32.5 mg OD) or low-dose (5.0 or 2.5 mg OD) groups. Patients with New York Heart Association classes II to IV CHF and left ventricular ejection fractions of no greater than 0.30 (n = 3164) were randomized and followed up for a median of 46 months. We examined the occurrence of adverse events and the need for discontinuation and dose reduction during treatment, with a focus on hypotension and renal dysfunction. Of 405 patients not previously receiving an ACE inhibitor, doses in only 4.2% could not be titrated to the medium doses required for randomization because of symptoms possibly related to hypotension (2.0%) or because of renal dysfunction or hyperkalemia (2.3%). Doses in more than 90% of randomized patients in the high- and low-dose groups were titrated to their assigned target, and the mean doses of blinded medication in both groups remained similar throughout the study. Withdrawals occurred in 27.1% of the high- and 30.7% of the low-dose groups. Subgroups presumed to be at higher risk for ACE inhibitor intolerance (blood pressure, or =132.6 micromol/L [> or =1.5 mg/dL]; age, > or =70 years; and patients with diabetes) generally tolerated the high-dose strategy. These findings demonstrate that ACE inhibitor therapy in most patients with CHF can be successfully titrated to and maintained at high doses, and that more aggressive use of these agents is warranted. JF - Archives of internal medicine AU - Massie, B M AU - Armstrong, P W AU - Cleland, J G AU - Horowitz, J D AU - Packer, M AU - Poole-Wilson, P A AU - Rydén, L AD - Department of Medicine, University of California-San Francisco and the Department of Veterans Affairs Medical Center, USA. Barry.Massie@med.va.gov Y1 - 2001/01/22/ PY - 2001 DA - 2001 Jan 22 SP - 165 EP - 171 VL - 161 IS - 2 SN - 0003-9926, 0003-9926 KW - Angiotensin-Converting Enzyme Inhibitors KW - 0 KW - Lisinopril KW - E7199S1YWR KW - Abridged Index Medicus KW - Index Medicus KW - Hypotension -- chemically induced KW - Drug Administration Schedule KW - Double-Blind Method KW - Humans KW - Aged KW - Hyperkalemia -- chemically induced KW - Male KW - Female KW - Kidney Diseases -- chemically induced KW - Lisinopril -- adverse effects KW - Heart Failure -- drug therapy KW - Angiotensin-Converting Enzyme Inhibitors -- adverse effects KW - Lisinopril -- administration & dosage KW - Angiotensin-Converting Enzyme Inhibitors -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70592910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Toleration+of+high+doses+of+angiotensin-converting+enzyme+inhibitors+in+patients+with+chronic+heart+failure%3A+results+from+the+ATLAS+trial.+The+Assessment+of+Treatment+with+Lisinopril+and+Survival.&rft.au=Massie%2C+B+M%3BArmstrong%2C+P+W%3BCleland%2C+J+G%3BHorowitz%2C+J+D%3BPacker%2C+M%3BPoole-Wilson%2C+P+A%3BRyd%C3%A9n%2C+L&rft.aulast=Massie&rft.aufirst=B&rft.date=2001-01-22&rft.volume=161&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-29 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preliminary Analyses of Hebrew Verbal Fluency Measures AN - 85551858; 200209893 AB - Hebrew language versions of phonemic & semantic fluency were administered to samples of normal control participants & individuals who had been hospitalized for 24 hours following a head injury. For the control sample, verbal fluency tasks were normally distributed & significantly correlated with education. The head injury sample's word generation was significantly lesser than that of the control's & not at all related to educational attainment. The findings provide evidence for the use of Hebrew fluency measures for clinical assessment & the need for collecting normative data across education levels. 1 Table, 9 References. Adapted from the source document JF - Applied Neuropsychology AU - Axelrod, Bradley N AU - Tomer, Rachel AU - Fisher, Tali AU - Aharon-Peretz, Judith AD - John D. Dingell Dept Veterans Affairs Medical Center, Detroit, MI bradley.axelrod@med.va.gov Y1 - 2001///0, PY - 2001 DA - 0, 2001 SP - 248 EP - 250 VL - 8 IS - 4 SN - 0908-4282, 0908-4282 KW - Memory (52750) KW - Brain Damage (09400) KW - Verbal Tasks (93800) KW - Lexical Access (46630) KW - Hebrew (31650) KW - Fluency (24910) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85551858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Neuropsychology&rft.atitle=Preliminary+Analyses+of+Hebrew+Verbal+Fluency+Measures&rft.au=Axelrod%2C+Bradley+N%3BTomer%2C+Rachel%3BFisher%2C+Tali%3BAharon-Peretz%2C+Judith&rft.aulast=Axelrod&rft.aufirst=Bradley&rft.date=2001-01-01&rft.volume=8&rft.issue=4&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Applied+Neuropsychology&rft.issn=09084282&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Brain Damage (09400); Verbal Tasks (93800); Fluency (24910); Lexical Access (46630); Memory (52750); Hebrew (31650) ER - TY - JOUR T1 - Possible Demographic Influences on Differentiating Normal from Aphasic Performance AN - 85539115; 200107371 AB - To determine the psychometric validity of current language impairment, communication activity limitation, & quality of life measures for differentiating normal from chronically aphasic adults, we examined possible threats to test accuracy by the demographic variables age, educational level, & gender. A total of 18 chronically aphasic & 18 nonaphasic adults were evaluated with six measures. The results of correlational analyses indicated that, within the normal adult & aphasic adult groups, there exist significant relationships between some, but not all, demographic variables & performance on language impairment, communication activity limitation, & quality of life measures. Moreover, for certain variables, the strengths of these relationships differ significantly between normal & aphasic groups. Thus, adjustments in test scores or norms may be necessary to diagnose the presence or absence of aphasia. Otherwise, the tests' ability to differentiate between normal & aphasic adults may be compromised. 4 Tables, 1 Appendix, 25 References. Adapted from the source document JF - Journal of Communication Disorders AU - Ross, Katherine B AU - Wertz, Robert T AD - Audiology & Speech Pathology Dept, Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ katherine.ross3@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 115 EP - 130 VL - 34 IS - 1-2 SN - 0021-9924, 0021-9924 KW - Education (20900) KW - Psychometric Analysis (69210) KW - Aphasia (03400) KW - Age Differences (01150) KW - Sex Differences (77850) KW - Test Validity and Reliability (88800) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85539115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Communication+Disorders&rft.atitle=Possible+Demographic+Influences+on+Differentiating+Normal+from+Aphasic+Performance&rft.au=Ross%2C+Katherine+B%3BWertz%2C+Robert+T&rft.aulast=Ross&rft.aufirst=Katherine&rft.date=2001-01-01&rft.volume=34&rft.issue=1-2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Journal+of+Communication+Disorders&rft.issn=00219924&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCDIAI N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Test Validity and Reliability (88800); Age Differences (01150); Education (20900); Sex Differences (77850); Psychometric Analysis (69210) ER - TY - JOUR T1 - Swallowing physiology of sequential straw drinking. AN - 85364599; pmid-11453563 AB - The goal of this study was to examine deglutitive physiology during sequential straw drinking in healthy young adults (n = 15) to learn how sequential swallowing differs from single swallows. The physiology of single swallows has been studied extensively in healthy adults and in adults with a variety of debilitating conditions, but the physiology of sequential swallows has not been studied adequately. Videofluoroscopic analysis revealed three distinct patterns of hyolaryngeal complex (HLC) movement during sequential straw swallows: opening of the laryngeal vestibule after each swallow (Type I, 53%), continued vestibule closure after each swallow (Type II, 27%), and interchangeable vestibule opening and closing during the swallow sequence (Mixed, 20%). Unlike discrete swallowing, the onset of the pharyngeal swallow occurred when the bolus was inferior to the valleculae in the majority of subjects and was significantly associated with HLC movement pattern. The leading bolus edge was inferior to the valleculae at swallow onset for Type II movement patterns. For Type I movement patterns, bolus position at swallow onset was randomly distributed between three anatomical positions: superior to the valleculae, at the level of the valleculae, and inferior to the valleculae. Preswallow pharyngeal bolus accumulation, which is common during mastication, was evident and significantly associated with the HLC pattern of opened laryngeal vestibule after each swallow. These data suggest that in healthy young adults, sequential swallows differ physiologically from discrete swallows and indicate substantial variability in deglutitive biomechanics. JF - Dysphagia AU - Daniels, S K AU - Foundas, A L AD - Speech Pathology Section, Veterans Affairs Medical Center, New Orleans, Louisiana 70112-1262, USA. stephanie.daniels@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 176 EP - 182 VL - 16 IS - 3 SN - 0179-051X, 0179-051X KW - National Library of Medicine KW - Adult KW - Biomechanics KW - *Deglutition: physiology KW - *Drinking: physiology KW - Humans KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85364599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dysphagia&rft.atitle=Swallowing+physiology+of+sequential+straw+drinking.&rft.au=Daniels%2C+S+K%3BFoundas%2C+A+L&rft.aulast=Daniels&rft.aufirst=S&rft.date=2001-01-01&rft.volume=16&rft.issue=3&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Dysphagia&rft.issn=0179051X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Scabies associated with radiation therapy for cutaneous T-cell lymphoma. AN - 77066189; 11314859 AB - Scabies, infection with Sarcoptes scabiei, is known to be predisposed to by poor body hygiene, environmental exposure, and systemic immunodeficiency. We report the case of an 83-year-old man with Sezary's syndrome who developed scabies limited to the skin of the upper chest, the same location where he had previously received electron beam radiation treatments for cutaneous T-cell lymphoma. Histologic and immunohistochemical studies demonstrated that sections of the previously irradiated right and left chest skin, compared to non-irradiated chest, abdominal, and leg skin, had infestation by scabies, diminished involvement by T-cell lymphoma, and notably reduced numbers of Langerhans cells. These findings suggest that the development of scabies may be predisposed to by local cutaneous radiation therapy, and that it may be mediated by local cutaneous immunodeficiency secondary to reduced numbers of Langerhans cells. JF - Annals of clinical and laboratory science AU - McGregor, D H AU - Yang, Q AU - Fan, F AU - Talley, R L AU - Topalovski, M AD - Department of Pathology and Laboratory Medicine, Veterans Affairs Medical Center, Kansas City, Missouri 64128, USA. mcgregor.d.@kansas-city.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 103 EP - 107 VL - 31 IS - 1 SN - 0091-7370, 0091-7370 KW - Index Medicus KW - Skin -- parasitology KW - Aged, 80 and over KW - Langerhans Cells -- pathology KW - Humans KW - Skin -- pathology KW - Gene Rearrangement KW - Aged KW - Sezary Syndrome -- complications KW - Male KW - Skin Neoplasms -- genetics KW - Lymphoma, T-Cell, Cutaneous -- complications KW - Lymphoma, T-Cell, Cutaneous -- genetics KW - Lymphoma, T-Cell, Cutaneous -- radiotherapy KW - Skin Neoplasms -- radiotherapy KW - Skin Neoplasms -- pathology KW - Skin Neoplasms -- complications KW - Lymphoma, T-Cell, Cutaneous -- pathology KW - Scabies -- etiology KW - Radiotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77066189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+clinical+and+laboratory+science&rft.atitle=Scabies+associated+with+radiation+therapy+for+cutaneous+T-cell+lymphoma.&rft.au=McGregor%2C+D+H%3BYang%2C+Q%3BFan%2C+F%3BTalley%2C+R+L%3BTopalovski%2C+M&rft.aulast=McGregor&rft.aufirst=D&rft.date=2001-01-01&rft.volume=31&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Annals+of+clinical+and+laboratory+science&rft.issn=00917370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-17 N1 - Date created - 2001-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Barriers to progress--the impact of tolerability problems. AN - 76970958; 11252523 AB - Side-effects of antipsychotic treatment are important factors in patients' compliance with treatment regimens. Of particular relevance to compliance are extrapyramidal symptoms (EPS), sedation, weight gain and sexual dysfunction. The new, atypical antipsychotics offer several tolerability benefits over conventional neuroleptics, particularly with respect to EPS. However, differences in their receptor binding characteristics result in different side-effect profiles. All novel antipsychotics have a high 5-HT2 to D2 receptor binding ratio, which is postulated to be important for a low liability for EPS. Ziprasidone, a new antipsychotic in the late stages of clinical development, has a low affinity for some receptor types, activation of which has been linked with adverse events such as sedation, postural hypotension, weight gain and cognitive impairment; for example, ziprasidone has minimal activity at muscarinic (M1), histaminergic (H1) and alpha1-adrenergic receptors. In short- and long-term clinical trials, ziprasidone had a low liability for side-effects typically associated with poor compliance, such as EPS, weight gain and sexual dysfunction. The tolerability profiles of the new antipsychotics represent a major improvement over the older neuroleptics. The more favourable the benefit/risk ratios of these new drugs throughout all phases of treatment, the greater the likelihood that patients will have better outcomes. JF - International clinical psychopharmacology AU - Casey, D E AD - Psychiatric Research and Psychopharmacology, Mental Health Division, Veterans Affairs Medical Center, Portland, Oregon, USA. daniel.casey@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - S15 EP - S19 VL - 16 Suppl 1 SN - 0268-1315, 0268-1315 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Hypotension, Orthostatic KW - Humans KW - Sexual Dysfunction, Physiological -- chemically induced KW - Cognition Disorders -- chemically induced KW - Weight Gain KW - Basal Ganglia Diseases -- chemically induced KW - Patient Compliance KW - Antipsychotic Agents -- therapeutic use KW - Antipsychotic Agents -- adverse effects KW - Psychotic Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76970958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+clinical+psychopharmacology&rft.atitle=Barriers+to+progress--the+impact+of+tolerability+problems.&rft.au=Casey%2C+D+E&rft.aulast=Casey&rft.aufirst=D&rft.date=2001-01-01&rft.volume=16+Suppl+1&rft.issue=&rft.spage=S15&rft.isbn=&rft.btitle=&rft.title=International+clinical+psychopharmacology&rft.issn=02681315&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-07 N1 - Date created - 2001-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stress-induced enhancement of auditory startle: an animal model of posttraumatic stress disorder. AN - 72420910; 11822211 AB - An innovative animal model of posttraumatic stress disorder (PTSD) is proposed in which nonhabituation of the acoustic startle response is developed in rats subsequent to tailshock exposure. Subjects (n = 31) received 30 minutes of intermittent tail shock on 2 days followed by exposure to the tailshock apparatus on the third day. Compared to baseline startle reactions, 9 of 31 tailshock-exposed rats developed nonhabituation of startle response reactions during the subsequent 3 weeks of testing. No control rats developed nonhabituation of startle reactions over a similar time period. These data suggest that this system models useful aspects of clinical PTSD emphasizing nonhabituation of startle reactions as a dependent variable. The method consistently identifies a subgroup of rats that develop persistent nonhabituation of startle in response to a tailshock-stress paradigm. JF - Psychiatry AU - Garrick, T AU - Morrow, N AU - Shalev, A Y AU - Eth, S AD - West Los Angeles VA Medical Center, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA. Thomas.Garrick@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 346 EP - 354 VL - 64 IS - 4 SN - 0033-2747, 0033-2747 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Disease Models, Animal KW - Behavior, Animal -- physiology KW - Habituation, Psychophysiologic KW - Male KW - Stress Disorders, Post-Traumatic -- psychology KW - Reinforcement (Psychology) KW - Reflex, Startle -- physiology KW - Noise -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72420910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry&rft.atitle=Stress-induced+enhancement+of+auditory+startle%3A+an+animal+model+of+posttraumatic+stress+disorder.&rft.au=Garrick%2C+T%3BMorrow%2C+N%3BShalev%2C+A+Y%3BEth%2C+S&rft.aulast=Garrick&rft.aufirst=T&rft.date=2001-01-01&rft.volume=64&rft.issue=4&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=Psychiatry&rft.issn=00332747&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-16 N1 - Date created - 2002-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of atypical antipsychotics on weight and serum lipid levels. AN - 72410205; 11806486 AB - Psychiatrists have become particularly concerned about health issues in patients with schizophrenia because of emerging data that link some of the newer atypical antipsychotics with both significant weight gain and increases in serum triglyceride levels. Excessive weight gain during antipsychotic therapy has an adverse effect on health and medication compliance, while hyperlipidemia presents an additional cardiovascular risk factor in patients with schizophrenia who typically smoke, are inactive, and possess poor dietary habits. An understanding of appropriate monitoring for metabolic adverse effects is important for those who prescribe atypical antipsychotics, as is a working knowledge of behavioral and pharmacologic treatments for weight gain and hyperlipidemia. JF - The Journal of clinical psychiatry AU - Meyer, J M AD - San Diego Veterans Affairs Medical Center and the Department of Psychiatry, University of California, 92161, USA. jonathan.meyer@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 27 EP - 34; discussion 40-1 VL - 62 Suppl 27 SN - 0160-6689, 0160-6689 KW - Antipsychotic Agents KW - 0 KW - Lipids KW - Index Medicus KW - Risk Factors KW - Hypertriglyceridemia -- chemically induced KW - Humans KW - Drug Monitoring KW - Hypertriglyceridemia -- blood KW - Obesity -- chemically induced KW - Lipids -- blood KW - Schizophrenia -- blood KW - Antipsychotic Agents -- therapeutic use KW - Body Weight -- drug effects KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72410205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Effects+of+atypical+antipsychotics+on+weight+and+serum+lipid+levels.&rft.au=Meyer%2C+J+M&rft.aulast=Meyer&rft.aufirst=J&rft.date=2001-01-01&rft.volume=62+Suppl+27&rft.issue=&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-07 N1 - Date created - 2002-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A definitive study of snakebite. 1968. AN - 72372242; 11769926 JF - Wilderness & environmental medicine AU - Snyder, C C AU - Pickins, J E AU - Knowles, R P AU - Emerson, J L AU - Hines, W A AD - Department of Surgery, University of Utah College of Medicine and Veterans Administration Hospital, Salt Lake City, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 276 EP - 279 VL - 12 IS - 4 SN - 1080-6032, 1080-6032 KW - Antivenins KW - 0 KW - Snake Venoms KW - Index Medicus KW - Emerson KW - Knowles KW - Snyder KW - Hines KW - Pickins KW - Animals KW - History, 20th Century KW - Viperidae KW - Humans KW - Antivenins -- history KW - Antivenins -- therapeutic use KW - Emergency Treatment -- history KW - Snake Venoms -- history KW - Snake Bites -- therapy KW - Snake Bites -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72372242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wilderness+%26+environmental+medicine&rft.atitle=A+definitive+study+of+snakebite.+1968.&rft.au=Snyder%2C+C+C%3BPickins%2C+J+E%3BKnowles%2C+R+P%3BEmerson%2C+J+L%3BHines%2C+W+A&rft.aulast=Snyder&rft.aufirst=C&rft.date=2001-01-01&rft.volume=12&rft.issue=4&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Wilderness+%26+environmental+medicine&rft.issn=10806032&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-11 N1 - Date created - 2001-12-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Wilderness Environ Med. 2001 Winter;12(4):273-5 [11769925] N1 - People - Snyder; Pickins; Knowles; Emerson; Hines N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Snyder; Pickins; Knowles; Emerson; Hines ER - TY - JOUR T1 - Helicobacter pylori and NSAIDs--what interaction. AN - 72297531; 11718528 AB - Much controversy surrounds the interaction of Helicobacter pylori infection and the use of Aspirin (ASA) or non-aspirin nonsteroidal anti-inflammatory drugs (NANSAIDs). The issue is comprised of many components, best dealt with singly. In summary, the severity of drug-associated gastritis, but not its incidence or prevalence, is influenced by infection prior to ASA or NANSAID therapy. Furthermore, the severity of dyspeptic symptoms appears worse in infected drug users. Both Chemical and Helicobacter gastritis, by increasing neutrophils in the tissue, lead to ulcers, although the induction of prostaglandin synthesis by inflammation in some circumstances may also be mildly protective. More ulcers are found in Hp+ve than Hp-ve users of NSAIDS, but ulcers in the stomach may heal more easily with acid suppressive therapy in infected patients. Eradication of infection is beneficial in aspirin users and in those beginning NANSAID therapy. Adaptation to aspirin is confined to Hp-ve cases. However, in long-term users of NANSAIDs, H. pylori eradication does not appear to speed ulcer healing, reduce recurrence, or prevent complications. These are best achieved by long-term maintenance therapy with a proton-pump inhibitor drug. JF - The European journal of surgery. Supplement. : = Acta chirurgica. Supplement AU - McCarthy, D M AD - Division of Gastroenterology & Hepatology, University of New Mexico HSC and Veterans Administration Medical Center, Albuquerque, USA. denis.mccarthy2@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 56 EP - 65 IS - 586 SN - 1102-416X, 1102-416X KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Index Medicus KW - Humans KW - Peptic Ulcer -- chemically induced KW - Helicobacter pylori KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Helicobacter Infections -- complications KW - Gastritis -- physiopathology KW - Gastritis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72297531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+journal+of+surgery.+Supplement.+%3A+%3D+Acta+chirurgica.+Supplement&rft.atitle=Helicobacter+pylori+and+NSAIDs--what+interaction.&rft.au=McCarthy%2C+D+M&rft.aulast=McCarthy&rft.aufirst=D&rft.date=2001-01-01&rft.volume=&rft.issue=586&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=The+European+journal+of+surgery.+Supplement.+%3A+%3D+Acta+chirurgica.+Supplement&rft.issn=1102416X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-28 N1 - Date created - 2001-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lack of effect of moderate Purkinje cell loss on working memory. AN - 72292359; 11718998 AB - 192 immunoglobulin G-saporin (192-sap) is an immunotoxin which targets the cholinergic basal forebrain after injection into either the ventricular system or the parenchyma of the rat brain. When injected by the i.c.v. route, 192-sap kills some cerebellar Purkinje cells in addition to its more extensive killing of the cholinergic basal forebrain. Behaviorally, i.c.v. injections of 192-sap result in impaired performance in a variety of experimental paradigms of learning and memory including a working memory task in the radial maze. The current study examined the contribution, if any, of immunotoxin-induced Purkinje cell loss to impaired performance in the radial maze. To meet this aim, we used i.c.v. injection of another immunotoxin, OX7-saporin (OX7-sap), at a dose that produced Purkinje cell loss of similar extent to that produced by i.c.v. 192-sap. We then compared these OX7-sap-injected rats with 192-sap-injected rats in a radial maze working memory task. We found a working memory impairment only in the 192-sap-injected rats. These data show that moderate Purkinje cell loss alone is insufficient to impair working memory. Furthermore, the data are consistent with the idea that the working memory deficit observed in 192-sap-injected animals is likely due to lesioning of the cholinergic basal forebrain. JF - Neuroscience AU - Wrenn, C C AU - Wiley, R G AD - Laboratory of Experimental Neurology, Veterans Administration Medical Center, Nashville, TN 37212, USA. wrennc@intra.nimh.nih.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 433 EP - 445 VL - 107 IS - 3 SN - 0306-4522, 0306-4522 KW - Antibodies, Monoclonal KW - 0 KW - Immunoconjugates KW - Immunotoxins KW - OX7-saporin KW - Ribosome Inactivating Proteins, Type 1 KW - N-Glycosyl Hydrolases KW - EC 3.2.2.- KW - Index Medicus KW - Animals KW - Maze Learning -- physiology KW - Neurons -- drug effects KW - Cholinergic Fibers -- physiology KW - Rats, Inbred BN KW - Rats KW - Choice Behavior -- drug effects KW - Prosencephalon -- physiology KW - Immunotoxins -- pharmacology KW - Injections KW - Memory -- physiology KW - Purkinje Cells -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72292359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Lack+of+effect+of+moderate+Purkinje+cell+loss+on+working+memory.&rft.au=Wrenn%2C+C+C%3BWiley%2C+R+G&rft.aulast=Wrenn&rft.aufirst=C&rft.date=2001-01-01&rft.volume=107&rft.issue=3&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-15 N1 - Date created - 2001-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Experimental options in the treatment of heart failure: the role of cytokine antagonism. AN - 71374886; 12634895 AB - Recent studies have identified the importance of biologically active molecules, such as neurohormones, as mediators of disease progression in heart failure. More recently, it has become apparent that, in addition to neurohormones, another portfolio of biologically active molecules, termed cytokines, are also expressed in the setting of heart failure. This article will review recent clinical material that suggests that tumor necrosis factor, a pro-inflammatory cytokine, may contribute to disease progression in heart failure by virtue of the direct toxic effects that this molecule exerts on the heart and circulation. In addition, this article reviews the existing clinical literature, which suggests that cytokine antagonism is safe and potentially effective in patients with heart failure. JF - Heart failure monitor AU - Kalra, D AU - Bozkurt, B AU - Deswal, A AU - Torre-Amione, G AU - Mann, D L AD - Winters Center for Heart Failure Research, Veterans Administration Medical Center and Baylor College of Medicine, Houston, TX 77030, USA. Y1 - 2001 PY - 2001 DA - 2001 SP - 114 EP - 121 VL - 1 IS - 4 SN - 1470-8590, 1470-8590 KW - Adrenergic beta-Antagonists KW - 0 KW - Angiotensin-Converting Enzyme Inhibitors KW - Cytokines KW - Neurotransmitter Agents KW - Index Medicus KW - Coronary Circulation -- physiology KW - Animals KW - Neurotransmitter Agents -- physiology KW - Angiotensin-Converting Enzyme Inhibitors -- therapeutic use KW - Ventricular Remodeling -- drug effects KW - Humans KW - Cytokines -- physiology KW - Cytokines -- antagonists & inhibitors KW - Adrenergic beta-Antagonists -- therapeutic use KW - Coronary Circulation -- drug effects KW - Ventricular Remodeling -- physiology KW - Heart Failure -- drug therapy KW - Heart Failure -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71374886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Heart+failure+monitor&rft.atitle=Experimental+options+in+the+treatment+of+heart+failure%3A+the+role+of+cytokine+antagonism.&rft.au=Kalra%2C+D%3BBozkurt%2C+B%3BDeswal%2C+A%3BTorre-Amione%2C+G%3BMann%2C+D+L&rft.aulast=Kalra&rft.aufirst=D&rft.date=2001-01-01&rft.volume=1&rft.issue=4&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Heart+failure+monitor&rft.issn=14708590&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-04 N1 - Date created - 2003-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Psychiatric care management for chronic addictive disorders: conceptual framework. AN - 71211733; 11579622 AB - Coexisting mental and addictive disorders are common, and service systems are not well configured to treat them. Psychiatrists frequently feel lacking in skills to address both the addictive disorder and the mental illness. Although programs for treating "dual disordered" patients have been under development, specialized programs are likely to provide treatment for only a minority of patients. Furthermore, many patients either do not respond to them or simply refuse to participate. This article describes care management, a clinical approach that can be applied to coexisting disorders by any practitioner. Care management complements rehabilitation treatment and completes the continuum of care. JF - The American journal on addictions AU - Willenbring, M L AD - Veterans Administration Medical Center and University of Minnesota, Minneapolis, Minn., USA. vhaminwillem@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 242 EP - 248 VL - 10 IS - 3 SN - 1055-0496, 1055-0496 KW - Index Medicus KW - Severity of Illness Index KW - Humans KW - Chronic Disease KW - Mental Disorders -- complications KW - Substance-Related Disorders -- complications KW - Mental Health Services -- standards KW - Substance-Related Disorders -- rehabilitation KW - Mental Health Services -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71211733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Psychiatric+care+management+for+chronic+addictive+disorders%3A+conceptual+framework.&rft.au=Willenbring%2C+M+L&rft.aulast=Willenbring&rft.aufirst=M&rft.date=2001-01-01&rft.volume=10&rft.issue=3&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-26 N1 - Date created - 2001-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Low-density lipoprotein induced actin cytoskeleton reorganization in endothelial cells: mechanisms of action. AN - 71202824; 11577705 AB - The inhibitory effects of the specific NADPH oxidase inhibitor, apocynin, and non-specific NADPH oxidase inhibitors, nordihydroguaiaretic acid (NDGA) and SKF525A, on the disruption of dense peripheral bands and formation of stress fibers in cultured human umbilical vein endothelial cells exposed to atherogenic low-density lipoprotein (LDL) levels has been investigated. Endothelial cells (EC) in vitro and in vivo exposed to high LDL-cholesterol levels have cytoskeletal remodeling with stress fiber formation and loss of dense peripheral bands. Cultured EC incubated with exogenously applied hydrogen peroxide (H2O2: 1 mM) have cytoskeletal structural changes much similar to those observed with high LDL exposure. Previous studies have 1) demonstrated that exposure to atherogenic LDL levels causes heightened EC H2O2 production, 2) identified the reactive oxygen species source, NADPH oxidase, in EC, and 3) shown that the specific NADPH oxidase inhibitor, apocynin, and non-specific NADPH oxidase inhibitors, NDGA and SKF525A, suppress H2O2 production increases in high LDL-perturbed EC. In the present study, the cytoskeletal structure of EC exposed to 330 mg/dl LDL-cholesterol, and incubated with or without apocynin, NDGA and SKF525A, was examined. Each of these compounds promoted the retention of dense peripheral bands and minimized stress fiber formation. These findings are consistent with NADPH oxidase and it's reactive oxygen species byproducts modulating the cytoskeleton reorganization observed in high LDL-induced EC perturbation. JF - Endothelium : journal of endothelial cell research AU - Holland, J A AU - Goss, R A AU - O'Donnell, R W AU - Chang, M M AU - Johnson, D K AU - Ziegler, L M AD - Department of Medicine, State University of New York Health Science Center Syracuse, 13210, USA. james.holland3@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 117 EP - 135 VL - 8 IS - 2 SN - 1062-3329, 1062-3329 KW - Acetophenones KW - 0 KW - Actins KW - Enzyme Inhibitors KW - Lipoproteins, LDL KW - Masoprocol KW - 7BO8G1BYQU KW - Proadifen KW - A510CA4CBT KW - acetovanillone KW - B6J7B9UDTR KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Index Medicus KW - Animals KW - Perfusion KW - Acetophenones -- pharmacology KW - Aorta, Abdominal -- ultrastructure KW - NADPH Oxidase -- antagonists & inhibitors KW - Humans KW - Umbilical Veins -- cytology KW - Rabbits KW - Arteriosclerosis -- chemically induced KW - Arteriosclerosis -- pathology KW - Microscopy, Fluorescence KW - Proadifen -- pharmacology KW - Cells, Cultured KW - Aorta, Thoracic -- ultrastructure KW - Enzyme Inhibitors -- pharmacology KW - Male KW - Masoprocol -- pharmacology KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Endothelium, Vascular -- cytology KW - Actin Cytoskeleton -- ultrastructure KW - Actins -- ultrastructure KW - Endothelium, Vascular -- ultrastructure KW - Actin Cytoskeleton -- drug effects KW - Lipoproteins, LDL -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71202824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endothelium+%3A+journal+of+endothelial+cell+research&rft.atitle=Low-density+lipoprotein+induced+actin+cytoskeleton+reorganization+in+endothelial+cells%3A+mechanisms+of+action.&rft.au=Holland%2C+J+A%3BGoss%2C+R+A%3BO%27Donnell%2C+R+W%3BChang%2C+M+M%3BJohnson%2C+D+K%3BZiegler%2C+L+M&rft.aulast=Holland&rft.aufirst=J&rft.date=2001-01-01&rft.volume=8&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Endothelium+%3A+journal+of+endothelial+cell+research&rft.issn=10623329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-21 N1 - Date created - 2001-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - From ETOH to FAB: the medicalization of therapy for pit viper envenomation. AN - 70940627; 11413771 JF - Transactions of the American Clinical and Climatological Association AU - Kitchens, C S AD - University of Florida, College of Medicine, Gainesville, FL 32610-0277, USA. craig.kitchens@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 117 EP - 135 VL - 112 SN - 0065-7778, 0065-7778 KW - Antivenins KW - 0 KW - Crotalid Venoms KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - History, 21st Century KW - History, 20th Century KW - Humans KW - History, 18th Century KW - History, Ancient KW - History, 19th Century KW - Antivenins -- history KW - Ethanol -- history KW - Antivenins -- therapeutic use KW - Ethanol -- therapeutic use KW - Crotalid Venoms -- toxicity KW - Snake Bites -- therapy KW - Crotalid Venoms -- history KW - Snake Bites -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70940627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+of+the+American+Clinical+and+Climatological+Association&rft.atitle=From+ETOH+to+FAB%3A+the+medicalization+of+therapy+for+pit+viper+envenomation.&rft.au=Kitchens%2C+C+S&rft.aulast=Kitchens&rft.aufirst=C&rft.date=2001-01-01&rft.volume=112&rft.issue=&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Transactions+of+the+American+Clinical+and+Climatological+Association&rft.issn=00657778&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-07 N1 - Date created - 2001-06-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Emerg Med. 2001 Feb;37(2):181-8 [11174237] Postgrad Med. 1966 Mar;39(3):265-9 [5911001] J Fla Med Assoc. 1968 Apr;55(4):330-7 [5646641] Toxicon. 1973 Oct;11(6):461-4 [4762264] JAMA. 1975 Jul 28;233(4):341-4 [1173647] J Fla Med Assoc. 1976 Mar;63(3):201-10 [175130] Thromb Res. 1977 Mar;10(3):487-94 [854881] JAMA. 1978 Aug 18;240(7):654-6 [671686] J Fla Med Assoc. 1980 Jan;67(1):21-7 [7351526] JAMA. 1982 Jan 22-29;247(4):461 [7054542] Am J Hematol. 1983 Jun;14(4):345-53 [6859033] Toxicon. 1984;22(2):177-82 [6729838] Lancet. 1986 Jul 26;2(8500):229 [2873481] Toxicon. 1987;25(4):455-8 [3617084] JAMA. 1987 Sep 25;258(12):1615-8 [3625968] Toxicon. 1987;25(12):1347-9 [3438923] Ann Emerg Med. 1988 Mar;17(3):254-6 [3257850] Am J Surg. 1989 Dec;158(6):543-7 [2589586] Ann Emerg Med. 1991 Jun;20(6):659-61 [2039106] Ann Emerg Med. 1992 Sep;21(9):1086-93 [1514719] Toxicon. 1992 May-Jun;30(5-6):573-9 [1519249] Hematol Oncol Clin North Am. 1992 Oct;6(5):1189-95 [1400081] Ann Emerg Med. 1997 Jul;30(1):33-9 [9209222] Ann Emerg Med. 1997 Jul;30(1):45-8 [9209224] Curr Opin Hematol. 1995 Sep;2(5):402-6 [9372026] Toxicon. 1999 Sep;37(9):1241-58 [10400286] Pediatrics. 1965 Aug;36:251-6 [14320035] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence of heart disease in asymptomatic chronic cocaine users. AN - 70897297; 11385188 AB - To determine the prevalence of heart disease in outpatient young asymptomatic chronic cocaine users, 35 cocaine users and 32 age-matched controls underwent resting and exercise electrocardiography (ECG) and Doppler echocardiography. Findings consistent with coronary artery disease were detected in 12 (34%) patients and 3 (9%) controls (p = 0.01). Decreased left ventricular systolic function was demonstrated in 5 (14%) patients, but in none of the controls (p = 0.055). Finally, resting and peak exercise abnormal left ventricular filling was detected in 38 and 35% of patients as compared to 19 and 9% of controls, respectively (p = 0.11 and 0.02, respectively). We conclude that coronary artery or myocardial disease is common (38%) in young asymptomatic chronic cocaine users. Therefore, screening ECG and echocardiography may be warranted in these patients. Copyright 2001 S. Karger AG, Basel. JF - Cardiology AU - Roldan, C A AU - Aliabadi, D AU - Crawford, M H AD - Cardiology, Veterans Affairs Medical Center and University of New Mexico Health Sciences Center, Albuquerque, NM, USA. Carlos.Roldan@med.va.gov Y1 - 2001 PY - 2001 DA - 2001 SP - 25 EP - 30 VL - 95 IS - 1 SN - 0008-6312, 0008-6312 KW - Index Medicus KW - Cardiomyopathies -- etiology KW - Humans KW - Echocardiography KW - Ventricular Dysfunction, Left -- chemically induced KW - Heart Function Tests KW - Logistic Models KW - Electrocardiography KW - Adult KW - Coronary Disease -- chemically induced KW - Case-Control Studies KW - Cardiomyopathies -- chemically induced KW - Female KW - Male KW - Heart Diseases -- chemically induced KW - Cocaine-Related Disorders -- physiopathology KW - Heart Diseases -- physiopathology KW - Cocaine-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70897297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cardiology&rft.atitle=Prevalence+of+heart+disease+in+asymptomatic+chronic+cocaine+users.&rft.au=Roldan%2C+C+A%3BAliabadi%2C+D%3BCrawford%2C+M+H&rft.aulast=Roldan&rft.aufirst=C&rft.date=2001-01-01&rft.volume=95&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Cardiology&rft.issn=00086312&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-09-13 N1 - Date created - 2001-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Biphasic effects of selegiline on striatal dopamine: lack of effect on methamphetamine-induced dopamine depletion. AN - 70837170; 11358284 AB - We tested the hypothesis that selegiline can attenuate dopamine depletion if administered following high doses of methamphetamine that cause neurotoxicity in the striatum. Methamphetamine produced decreases of 50% or greater in both striatal concentrations of dopamine and combined concentrations of homovanillic acid and DOPAC in mice. For animals not exposed to methamphetamine, chronic treatment with selegiline over 18 days caused biphasic effects on striatal dopamine content, with decreases, no effect, or increases observed for mice receiving treatment with 0.02, 0.2, and 2.0 mg/kg, respectively. Selegiline failed to modify methamphetamine-induced reductions in striatal dopamine content or combined concentrations of homovanillic acid and DOPAC. Significant increases in mortality following the onset of selegiline treatment (24 hours after the initial dose of methamphetamine) occurred in methamphetamine-treated mice that received saline or 2.0 mg/kg of selegiline, but not for mice treated with 0.02 or 0.2 mg/kg of selegiline. These results indicate that selegiline fails to attenuate dopamine depletion when administered chronically following exposure to methamphetamine, but may attenuate methamphetamine-induced mortality. In control animals that did not receive methamphetamine, low doses of selegiline produced decreases the concentration of striatal dopamine, while high dose treatment caused increases in striatal dopamine content. JF - Neurochemical research AU - Grasing, K AU - Azevedo, R AU - Karuppan, S AU - Ghosh, S AD - Veterans Administration Medical Center, Kansas City, Missouri 64128, USA. kenneth.grasing@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 65 EP - 74 VL - 26 IS - 1 SN - 0364-3190, 0364-3190 KW - Dopamine Uptake Inhibitors KW - 0 KW - Monoamine Oxidase Inhibitors KW - Neurotoxins KW - Selegiline KW - 2K1V7GP655 KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Neurotoxins -- pharmacology KW - Mice KW - Male KW - Selegiline -- pharmacology KW - Corpus Striatum -- metabolism KW - Methamphetamine -- pharmacology KW - Dopamine -- metabolism KW - Corpus Striatum -- drug effects KW - Monoamine Oxidase Inhibitors -- pharmacology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70837170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+research&rft.atitle=Biphasic+effects+of+selegiline+on+striatal+dopamine%3A+lack+of+effect+on+methamphetamine-induced+dopamine+depletion.&rft.au=Grasing%2C+K%3BAzevedo%2C+R%3BKaruppan%2C+S%3BGhosh%2C+S&rft.aulast=Grasing&rft.aufirst=K&rft.date=2001-01-01&rft.volume=26&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Neurochemical+research&rft.issn=03643190&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-10-11 N1 - Date created - 2001-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic alterations in head and neck cancer: interactions among environmental carcinogens, cell cycle control, and host DNA repair. AN - 70590642; 11123872 AB - Head and neck squamous cell carcinomas (HNSCC) arise as a consequence of cumulative genetic changes brought about by continued exposure to carcinogens associated with tobacco and alcohol use, influenced by viral agents such as human papillomaviruses, in a background of acquired or heritable genetic susceptibility. The presence of widespread genomic instability in HNSCC, such as cytogenetic aberrations, allelic imbalance/loss of heterozygosity, and microsatellite instability, suggests that there is an imperfection in the host DNA repair machinery. Genomic instability with progressive accumulation of detrimental genetic alterations appears to be dependent upon a circuitous interaction between the environmental genotoxic insults and the host DNA repair machinery, the functional integrity of which is governed by the proper cell cycle control and host DNA repair capacity. Thus, it can be hypothesized that continued exposure to environmental carcinogens (ie, longstanding history of smoking and drinking), loss of proper cell cycle control (eg, inactivation of p53 or p16 tumor suppressor genes or amplification of the proto-oncongene cyclin D1), and impaired DNA repair capacity (both inherited and acquired) are prerequisites in head and neck carcinogenesis. JF - Current oncology reports AU - Fan, C Y AD - Department of Pathology and Otolaryngology, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA. chun.fan@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 66 EP - 71 VL - 3 IS - 1 SN - 1523-3790, 1523-3790 KW - Carcinogens KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Neoplasm Staging KW - DNA Damage KW - Cell Cycle -- physiology KW - Humans KW - Alcohol Drinking -- adverse effects KW - Disease Progression KW - Prognosis KW - Smoking -- adverse effects KW - Carcinogens -- metabolism KW - Risk Factors KW - Female KW - Male KW - Survival Analysis KW - Carcinogens -- adverse effects KW - DNA Repair -- genetics KW - Head and Neck Neoplasms -- metabolism KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- mortality KW - Carcinoma, Squamous Cell -- genetics KW - Head and Neck Neoplasms -- pathology KW - Head and Neck Neoplasms -- mortality KW - Carcinoma, Squamous Cell -- metabolism KW - Head and Neck Neoplasms -- genetics KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70590642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+oncology+reports&rft.atitle=Genetic+alterations+in+head+and+neck+cancer%3A+interactions+among+environmental+carcinogens%2C+cell+cycle+control%2C+and+host+DNA+repair.&rft.au=Fan%2C+C+Y&rft.aulast=Fan&rft.aufirst=C&rft.date=2001-01-01&rft.volume=3&rft.issue=1&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Current+oncology+reports&rft.issn=15233790&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-18 N1 - Date created - 2001-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rhabdomyolysis secondary to a drug interaction between simvastatin and clarithromycin. AN - 70590407; 11197581 AB - To report a case of rhabdomyolysis resulting from concomitant use of clarithromycin and simvastatin. A 64-year-old African-American man was admitted to the hospital for worsening renal failure, elevated creatine phosphokinase, diffuse muscle pain, and severe muscle weakness. About three weeks prior to admission, the patient was started on clarithromycin for sinusitis. The patient had been receiving simvastatin for approximately six months. He was treated aggressively with intravenous hydration, sodium bicarbonate, and hemodialysis. A muscle biopsy revealed necrotizing myopathy secondary to a toxin. The patient continued to receive intermittent hemodialysis until his death from infectious complications that occurred three months after admission. There were several factors that could have increased his risk for developing rhabdomyolysis, including chronic renal failure. Clarithromycin is a potent inhibitor of CYP3A4, the major enzyme responsible for simvastatin metabolism. The concomitant administration of macrolide antibiotics and other hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors have resulted in previous reports of rhabdomyolysis. Other factors may increase the risk of this drug interaction, including the administration of other medications that are associated with myopathy, underlying renal insufficiency, and administration of high doses of HMG-CoA reductase inhibitors. Macrolide antibiotics inhibit the metabolism of HMG-CoA reductase inhibitors that are metabolized by CYP3A4 (i.e., atorvastatin, cerivastatin, lovastatin, simvastatin). This interaction may result in myopathy and rhabdomyolysis, particularly in patients with renal insufficiency or those who are concurrently taking medications associated with myopathy. JF - The Annals of pharmacotherapy AU - Lee, A J AU - Maddix, D S AD - University of the Pacific, Stockton, CA, USA. lee.audrey_J@sanfrancisco.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 26 EP - 31 VL - 35 IS - 1 SN - 1060-0280, 1060-0280 KW - Anti-Bacterial Agents KW - 0 KW - Hypolipidemic Agents KW - Simvastatin KW - AGG2FN16EV KW - Clarithromycin KW - H1250JIK0A KW - Index Medicus KW - Drug Interactions KW - Humans KW - Hyperlipidemias -- drug therapy KW - Sinusitis -- drug therapy KW - Middle Aged KW - Male KW - Simvastatin -- therapeutic use KW - Simvastatin -- adverse effects KW - Anti-Bacterial Agents -- therapeutic use KW - Hypolipidemic Agents -- therapeutic use KW - Rhabdomyolysis -- chemically induced KW - Anti-Bacterial Agents -- adverse effects KW - Rhabdomyolysis -- pathology KW - Hypolipidemic Agents -- adverse effects KW - Clarithromycin -- therapeutic use KW - Clarithromycin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70590407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Rhabdomyolysis+secondary+to+a+drug+interaction+between+simvastatin+and+clarithromycin.&rft.au=Lee%2C+A+J%3BMaddix%2C+D+S&rft.aulast=Lee&rft.aufirst=A&rft.date=2001-01-01&rft.volume=35&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-08 N1 - Date created - 2001-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cyclooxygenase 2 and the kidney. AN - 70579313; 11195058 AB - Cyclooxygenase metabolizes arachidonic acid to a family of bioactive fatty acids designated prostaglandins. Two isoforms of cyclooxygenase exist, designated COX1 and COX2. These isoforms are expressed in distinct but important areas of the kidney. COX1 predominates in vascular smooth muscle and collecting ducts, whereas COX2 predominates in the macula densa and nearby cells in the cortical thick ascending limb. COX2 is also highly expressed in medullary interstitial cells. Whereas COX1 expression does not exhibit dynamic regulation, COX2 expression is subject to regulation by several environmental conditions, including salt intake, water intake, medullary tonicity, growth factors, cytokines, and adrenal steroids. Recently, COX2-selective non-steroidal anti-inflammatory drugs have become widely available. Many of the renal effects of non-selective non-steroidal anti-inflammatory drugs (including sodium retention, decreased glomerular filtration rate, and effects on renin-angiotensin levels) appear to be mediated by the inhibition of COX2 rather than COX1. Therefore, in contrast to the gastrointestinal-sparing effects of COX2-selective non-steroidal anti-inflammatory drugs, when considering the kidney, the same caution must be applied when using COX2-selective inhibitors as has been used with traditional non-selective non-steroidal anti-inflammatory drugs. JF - Current opinion in nephrology and hypertension AU - Breyer, M D AU - Harris, R C AD - Department of Medicine, Veterans Administration Medical Center and Vanderbilt University, Nashville, Tennessee, USA. matthew.breyer@mcmail.vanderbilt.edu Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 89 EP - 98 VL - 10 IS - 1 SN - 1062-4821, 1062-4821 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Isoenzymes KW - Membrane Proteins KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Index Medicus KW - Kidney Diseases -- physiopathology KW - Animals KW - Anti-Inflammatory Agents, Non-Steroidal -- antagonists & inhibitors KW - Humans KW - Kidney Diseases -- chemically induced KW - Prostaglandin-Endoperoxide Synthases -- physiology KW - Isoenzymes -- physiology KW - Kidney -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70579313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+nephrology+and+hypertension&rft.atitle=Cyclooxygenase+2+and+the+kidney.&rft.au=Breyer%2C+M+D%3BHarris%2C+R+C&rft.aulast=Breyer&rft.aufirst=M&rft.date=2001-01-01&rft.volume=10&rft.issue=1&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+nephrology+and+hypertension&rft.issn=10624821&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-08 N1 - Date created - 2001-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of every-third-day versus daily low-dose aspirin therapy on serum thromboxane concentrations in healthy men and women. AN - 70577915; 11190906 AB - Aspirin's antithrombotic effect is mediated predominately by inhibition of platelet cyclooxygenase-1, leading to a decline in serum thromboxane A2 concentrations. We performed a placebo-controlled, randomized, double-blind trial to determine whether aspirin could be given at 3-day intervals and still achieve potent serum thromboxane inhibition. One hundred nine healthy men and women with no recent exposure to aspirin and no contraindications to its use participated. Subjects received 325 mg, 81 mg, or 40 mg of plain aspirin every third day, with placebo on other days; 81 mg of aspirin every day; or placebo every day. Serum concentrations of thromboxane B2 (the metabolite of thromboxane A2) were measured at 3-day intervals during a 31-day treatment period, as well as 4, 7, and 14 days after treatment ended. Serum thromboxane B2 concentrations were nearly identical during treatment with 325 mg of aspirin every third day or 81 mg of aspirin per day (86% inhibition [84%, 89%] and 85% inhibition [73%, 96%], respectively). An aspirin dose of 81 mg every third day was nearly as potent (74% inhibition [70%, 79%]), whereas 40 mg of aspirin every third day achieved only 50% inhibition (40%, 60%). Every-third-day low-dose aspirin regimens (325 and 81 mg) deserve comparison with daily low-dose aspirin regimens in controlled clinical trials because the former regimens could prove to have equal efficacy with reduced toxicity. JF - Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis AU - Feldman, M AU - Cryer, B AU - Rushin, K AU - Betancourt, J AD - Medical Service, Dallas Department of Veterans Affairs Medical Center and University of Texas Southwestern Medical School, 75216, USA. feldman.mark@dallas.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 53 EP - 57 VL - 7 IS - 1 SN - 1076-0296, 1076-0296 KW - Platelet Aggregation Inhibitors KW - 0 KW - Thromboxanes KW - Thromboxane B2 KW - 54397-85-2 KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Pilot Projects KW - Middle Aged KW - Adolescent KW - Time Factors KW - Male KW - Female KW - Thromboxane B2 -- blood KW - Platelet Aggregation Inhibitors -- administration & dosage KW - Thromboxanes -- blood KW - Aspirin -- adverse effects KW - Aspirin -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70577915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+applied+thrombosis%2Fhemostasis+%3A+official+journal+of+the+International+Academy+of+Clinical+and+Applied+Thrombosis%2FHemostasis&rft.atitle=A+comparison+of+every-third-day+versus+daily+low-dose+aspirin+therapy+on+serum+thromboxane+concentrations+in+healthy+men+and+women.&rft.au=Feldman%2C+M%3BCryer%2C+B%3BRushin%2C+K%3BBetancourt%2C+J&rft.aulast=Feldman&rft.aufirst=M&rft.date=2001-01-01&rft.volume=7&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Clinical+and+applied+thrombosis%2Fhemostasis+%3A+official+journal+of+the+International+Academy+of+Clinical+and+Applied+Thrombosis%2FHemostasis&rft.issn=10760296&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-03 N1 - Date created - 2001-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Predictors and outcomes of outpatient mental health care: a 4-year prospective study of elderly Medicare patients with substance use disorders. AN - 70575829; 11176542 AB - Many elderly inpatients have substance use disorders; recent treatment guidelines suggest that they should receive regular outpatient mental health care after discharge from hospital. The prevalence, predictors, and outcomes of outpatient mental health care obtained by elderly Medicare patients with substance use disorders were examined. A longitudinal prospective follow-up was performed. Data from Medicare Provider Analysis and Review Record and Part B Medicare Annual Data were used to identify elderly inpatients with substance use disorders (n = 4,961) and determine their outpatient mental health care 4 years following hospital discharge. Only 12% to 17% of surviving elderly substance abuse patients received outpatient mental health care in each of 4 years after discharge. Cumulatively over 4 years, approximately 18% of surviving patients obtained diagnostic/evaluative mental health services, 22% obtained psychotherapy, and 9% received medication management. Of patients who obtained outpatient mental health care, 57% made 10 or fewer outpatient mental health visits over the entire 4 years. Younger, non-black, and female patients were more likely to obtain mental health outpatient care, as were patients with prior substance-related hospitalizations, dual diagnoses, and fewer medical conditions. Prompt outpatient mental health care was predictively associated with higher likelihood of mental health readmissions and, among patients with drug disorders, lower mortality. Very few elderly Medicare substance abuse patients obtain outpatient mental health care, perhaps because of health or economic barriers. JF - Medical care AU - Brennan, P L AU - Kagay, C R AU - Geppert, J J AU - Moos, R H AD - Center for Health Care Evaluation, VA Palo Alto Health Care System and Stanford University Medical Center, California 94304, USA. penny.brennan@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 39 EP - 49 VL - 39 IS - 1 SN - 0025-7079, 0025-7079 KW - Index Medicus KW - Alcoholism -- rehabilitation KW - Analysis of Variance KW - Sex Factors KW - Humans KW - Medicare KW - Aged KW - Patient Readmission KW - Prospective Studies KW - Logistic Models KW - Risk Factors KW - Treatment Outcome KW - Follow-Up Studies KW - United States -- epidemiology KW - Female KW - Male KW - Mental Health Services -- utilization KW - Substance-Related Disorders -- mortality KW - Substance-Related Disorders -- rehabilitation KW - Aftercare -- utilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70575829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=Predictors+and+outcomes+of+outpatient+mental+health+care%3A+a+4-year+prospective+study+of+elderly+Medicare+patients+with+substance+use+disorders.&rft.au=Brennan%2C+P+L%3BKagay%2C+C+R%3BGeppert%2C+J+J%3BMoos%2C+R+H&rft.aulast=Brennan&rft.aufirst=P&rft.date=2001-01-01&rft.volume=39&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=00257079&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-01 N1 - Date created - 2001-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug resistance mechanisms in acute leukemia. AN - 70575547; 11148681 AB - Markers of anticancer drug resistance are predictive of treatment response and outcome in patients with acute myeloid leukemia. Immunologic detection of the drug efflux pumps, P-glycoprotein (Pgp) and multidrug resistance-associated protein 1 (MRP1), correlate with functional assays of drug resistance. These accumulation defects also appear operable in acute lymphoblastic leukemia. Many of the efflux pumps identified share significant structural homology with the large superfamily of ATP-binding cassette transporters. Other markers such as lung-resistance protein, bcl-2, and breast cancer-resistance protein, have been described in acute myeloid leukemia patients although their pathophysiology and clinical relevance are less clear and the methodology for their quantification are not well standardized. Preclinical studies have shown that small molecules capable of reversing efflux can restore drug sensitivity in resistant tumor models. Although initial clinical studies were limited by both potency and specificity of the reverser, later studies with more effective reversers have in many instances been limited by pharmacokinetic interactions exacerbating the clinical toxicities of chemotherapy. Although one large randomized study has demonstrated a proven survival advantage without increased toxicity using cyclosporine, the inconsistent results with other modulators raise doubt as to the utility and overall strategy of using drug efflux blockers in patients with established Pgp overexpression. Many of these patients have additional resistance mechanisms, and achieving meaningful clinical responses will likely require more complex clinical strategies. Preventing or delaying development of drug resistance in chemosensitive patients represents another therapeutic strategy to be tested. JF - Current opinion in oncology AU - Chauncey, T R AD - Marrow Transplant Unit, VA Puget Sound Health Care System, Seattle, Washington, USA. thomas.chauncey@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 21 EP - 26 VL - 13 IS - 1 SN - 1040-8746, 1040-8746 KW - Biomarkers, Tumor KW - 0 KW - Multidrug Resistance-Associated Proteins KW - P-Glycoprotein KW - Index Medicus KW - Phenotype KW - Gene Expression Regulation, Neoplastic KW - Randomized Controlled Trials as Topic KW - Drug Interactions KW - Humans KW - Prognosis KW - Survival Analysis KW - Leukemia -- drug therapy KW - P-Glycoprotein -- pharmacology KW - P-Glycoprotein -- genetics KW - ATP-Binding Cassette Transporters -- pharmacology KW - Biomarkers, Tumor -- analysis KW - Drug Resistance, Neoplasm KW - Leukemia -- physiopathology KW - Leukemia -- genetics KW - Drug Resistance, Multiple UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70575547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+oncology&rft.atitle=Drug+resistance+mechanisms+in+acute+leukemia.&rft.au=Chauncey%2C+T+R&rft.aulast=Chauncey&rft.aufirst=T&rft.date=2001-01-01&rft.volume=13&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+oncology&rft.issn=10408746&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-15 N1 - Date created - 2001-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Superoxide dismutase and pulmonary oxygen toxicity: lessons from transgenic and knockout mice (Review). AN - 70541017; 11115602 AB - Superoxide (O2-) has been implicated in the pathogenesis of pulmonary O2 toxicity. The studies using transgenic and knockout mice of each of the three isoforms of superoxide dismutase (SOD) e.g. , CuZnSOD, MnSOD and extracellular SOD (EC-SOD), have demonstrated that O2- produced in the mitochondria from its electron transport system and extracellular O2- generated by infiltrating neutrophils, and possibly its derivatives e.g., hydroxyl radical and peroxynitrite, are important mediators of hyperoxia-induced pulmonary injury, while cytoplasmic O2- plays a limited, if any, role in the pathogenesis of pulmonary O2 toxicity. Distal airway epithelial cells including type II alveolar and non-ciliated bronchiolar epithelial cells, are important targets for O2 radicals under the hyperoxic condition. The accessibility of these distal airway epithelial cells to in vivo gene transfer through the tracheal route of administration, suggests the potential for in vivo transfer of MnSOD and EC-SOD genes as a future approach in the prevention of pulmonary O2 toxicity. JF - International journal of molecular medicine AU - Tsan, M F AD - Research Service (151), Stratton VA Medical Center, Albany, NY 12208, USA. min-fu.tsan@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 13 EP - 19 VL - 7 IS - 1 SN - 1107-3756, 1107-3756 KW - Superoxides KW - 11062-77-4 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Animals KW - Superoxides -- metabolism KW - Mice KW - Mice, Transgenic KW - Mice, Knockout KW - Oxygen -- toxicity KW - Oxygen -- metabolism KW - Lung -- drug effects KW - Superoxide Dismutase -- metabolism KW - Superoxide Dismutase -- genetics KW - Lung -- pathology KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70541017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+molecular+medicine&rft.atitle=Superoxide+dismutase+and+pulmonary+oxygen+toxicity%3A+lessons+from+transgenic+and+knockout+mice+%28Review%29.&rft.au=Tsan%2C+M+F&rft.aulast=Tsan&rft.aufirst=M&rft.date=2001-01-01&rft.volume=7&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=International+journal+of+molecular+medicine&rft.issn=11073756&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2000-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - An Assessment of Blind Rehabilitation Training and Technology Utilization of Visually Impaired Veterans T2 - Southern Sociological Society AN - 61736640; 2001S40261 AB - While considerable data has been developed on veterans attending VA blind rehabilitation programs, very little information is available on veterans who are unable or chose not to avail themselves of these services. This information is crucial in the design &/or optimization of the delivery of clinical services & assistive technology to this veteran population. Visually impaired veterans (N = 14,100) were surveyed in an effort to obtain basic demographic information, date & type of last blind rehabilitation service, receipt of prosthetic devices from the VA, living situation, visual status, current use of computer technology, as well as perceived specific rehabilitation needs. The typical demographic profile of survey respondents was that of a recreationally active, 71-80-year-old person living with a spouse, family member, or roommate. Findings from these data demonstrate that 43.2% of respondents had never received VA-sponsored blind rehabilitation training, & that younger veterans appear to receive VA blind rehabilitation services more often than do older veterans. These findings suggest a potential disparity in service delivery of VA-sponsored rehabilitation training programs for blind & visually impaired veterans. JF - Southern Sociological Society AU - Williams, Michael D Y1 - 2001///0, PY - 2001 DA - 0, 2001 KW - Veterans KW - Blind KW - Vocational Rehabilitation KW - Medical Technology KW - United States of America KW - Social Services Utilization KW - proceeding KW - 2148: social problems and social welfare; social work & welfare services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61736640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Southern+Sociological+Society&rft.atitle=An+Assessment+of+Blind+Rehabilitation+Training+and+Technology+Utilization+of+Visually+Impaired+Veterans&rft.au=Williams%2C+Michael+D&rft.aulast=Williams&rft.aufirst=Michael&rft.date=2001-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Southern+Sociological+Society&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2009-03-10 N1 - Publication note - 2001 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Gender Awareness among Veterans Administration Health-Care Workers: Existing Strengths and Areas for Improvement AN - 61509409; 200204656 AB - In response to the growing number of women within the Veterans Health Administration (VHA), along with the challenge of meeting their health care needs in a historically male-focused setting, VHA has supported a variety of research projects aimed at evaluating & improving the status of women's health & health care experiences. While these efforts have primarily focused on aspects of care such as the availability & accessibility of services & the provision of timely care, this study focused on the contribution of interpersonal aspects of care. Specifically, staff gender awareness, conceptualized as health care workers' gender role ideology or attitudes, gender sensitivity, & knowledge was examined. Findings revealed both strengths & weaknesses in domains of staff gender awareness components. 3 Tables, 39 References. Adapted from the source document. JF - Women and Health AU - Vogt, Dawne S AU - Stone, Erika R AU - Salgado, Dawn M AU - King, Lynda A AU - King, Daniel W AU - Savarese, Vincent W AD - National Center Post-traumatic Stress Disorder, Boston, MA vogt.dawne@boston.va.gov Y1 - 2001///0, PY - 2001 DA - 0, 2001 SP - 65 EP - 83 VL - 34 IS - 4 SN - 0363-0242, 0363-0242 KW - Veterans KW - Health Professions KW - Northern States KW - Womens Health Care KW - Sex Role Attitudes KW - Practitioner Patient Relationship KW - Knowledge KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61509409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women+and+Health&rft.atitle=Gender+Awareness+among+Veterans+Administration+Health-Care+Workers%3A+Existing+Strengths+and+Areas+for+Improvement&rft.au=Vogt%2C+Dawne+S%3BStone%2C+Erika+R%3BSalgado%2C+Dawn+M%3BKing%2C+Lynda+A%3BKing%2C+Daniel+W%3BSavarese%2C+Vincent+W&rft.aulast=Vogt&rft.aufirst=Dawne&rft.date=2001-01-01&rft.volume=34&rft.issue=4&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Women+and+Health&rft.issn=03630242&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - WOHEDI N1 - SubjectsTermNotLitGenreText - Womens Health Care; Health Professions; Sex Role Attitudes; Veterans; Knowledge; Practitioner Patient Relationship; Northern States ER - TY - JOUR T1 - Putting Theory into Practice: A Psychologist's Story AN - 61504371; 200103792 AB - A diagnosis of breast cancer is a frightening & life-changing experience. It affects not only the physical body, but also one's psychological well-being & basic assumptions about the world. Paradoxically, having breast cancer can provide an opportunity for personal growth & finding new meaning in life. While coping with cancer is basically an individual task, coping skills, social support, & an empathic therapist can help the breast cancer patient manage this stressful time. This article explores my own experience with breast cancer & the resources & coping strategies that were most helpful in getting through this frightening time. I will discuss how my experience forced me to face my own mortality & led me to an inner strength & courage that I had not used before. By joining the ranks of those who have faced intense anxiety & fear during a serious life crisis, I have greater empathy for & understanding of my own patients' struggles. 17 References. Adapted from the source document. JF - Women & Therapy AU - Fischer, Pamela C AD - Dept Veterans Affairs Medical Center, Oklahoma City Pamela.Fischer@med.va.gov Y1 - 2001///0, PY - 2001 DA - 0, 2001 SP - 101 EP - 109 VL - 23 IS - 1 SN - 0270-3149, 0270-3149 KW - breast cancer KW - Support Networks KW - Theory Practice Relationship KW - Womens Health Care KW - Narratives KW - Coping KW - Illness KW - Cancer KW - Empathy KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61504371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women+%26+Therapy&rft.atitle=Putting+Theory+into+Practice%3A+A+Psychologist%27s+Story&rft.au=Fischer%2C+Pamela+C&rft.aulast=Fischer&rft.aufirst=Pamela&rft.date=2001-01-01&rft.volume=23&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Women+%26+Therapy&rft.issn=02703149&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - WOTHDJ N1 - SubjectsTermNotLitGenreText - Womens Health Care; Cancer; Support Networks; Empathy; Theory Practice Relationship; Narratives; Illness; Coping ER - TY - JOUR T1 - Social Reinforcement of Substance Abuse Aftercare Group Therapy Attendance AN - 61492841; 200103929 AB - Although adherence to aftercare therapy in substance abuse treatment is associated with improved treatment outcome, relatively little research has explored methods of improving aftercare adherence. To improve on established methods of promoting aftercare adherence, 43 graduates of the 28-day intensive substance abuse treatment program at the Salem Veteran's Affairs Medical Center who received standard aftercare orientation are compared to 38 graduates who received the standard intervention plus social reinforcement of aftercare group therapy attendance. Clients who received social reinforcement attended more aftercare group sessions than did clients who received the standard treatment during the 8-week intervention (68.8% vs. 49.4% of sessions attended), & during the 4-week follow-up period (41.5% vs. 31.4% of sessions). These findings are noteworthy since the standard treatment had been shown to be effective in increasing aftercare adherence in prior studies (Lash, 1998; Lash & Blosser, 1999). Areas for future research are discussed. 1 Figure, 20 References. Adapted from the source document. JF - Journal of Substance Abuse Treatment AU - Lash, Steven J AU - Petersen, Gregory E AU - O'Connor, Edmund A, Jr AU - Lehmann, Lauren P AD - Substance Abuse Residential Rehabilitation Treatment Program, Veterans Affairs Medial Center, Salem, VA steven.lash@med.va.gov Y1 - 2001/01// PY - 2001 DA - January 2001 SP - 3 EP - 8 VL - 20 IS - 1 SN - 0740-5472, 0740-5472 KW - Veterans KW - Substance Abuse KW - Virginia KW - After Care KW - Treatment Programs KW - Treatment Compliance KW - Reinforcement KW - Treatment Methods KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61492841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Social+Reinforcement+of+Substance+Abuse+Aftercare+Group+Therapy+Attendance&rft.au=Lash%2C+Steven+J%3BPetersen%2C+Gregory+E%3BO%27Connor%2C+Edmund+A%2C+Jr%3BLehmann%2C+Lauren+P&rft.aulast=Lash&rft.aufirst=Steven&rft.date=2001-01-01&rft.volume=20&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Substance Abuse; Treatment Programs; After Care; Treatment Compliance; Reinforcement; Treatment Methods; Veterans; Virginia ER - TY - JOUR T1 - The effects of selection for larval behavior on adult life-history features in Drosophila melanogaster AN - 18284710; 5336280 AB - Selection for late-life fecundity and longevity in adult Drosophila melanogaster is well known to modify numerous characteristics of life history and physiology. We report experiments here in which selection applied to behavior affects features in an identical fashion. Selection for feeding rate of larval D. melanogaster modifies caloric intake, as measured by the uptake and incorporation of labeled glucose. Selection for slow larval feeding produced lines of D. melanogaster in which larvae synthesized significantly less lipid prior to pupation and eclosed to have low early-life fecundity and a long life as adults. They also had greater lifetime fecundity, but lower viability of egg to hatched adult. Alternatively, fast-feeding larvae incorporated more lipid before pupation and eclosed with high early-fecundity that declined rapidly throughout their short adult life. Slow-feeding populations also had a significantly enhanced expression of the stress-resistance genes CuZn-SOD, CATALASE, and HSP70. Selection on larval feeding behavior reproduced the antagonistic evolutionary trade-off found under selection for adult life span and mimicked the physiological response in life span as seen in many species when dietary restriction is imposed on adults. Thus, nutrient acquisition during development appears to share a common evolutionary and genetic basis with the allocation processes that determine adult life-history traits and the related phenotypic dietary restriction phenomena. JF - Evolution AU - Foley, P A AU - Luckinbill, L S AD - Department of Surgery, Veterans Administration Medical Center, Route 11S, Detroit, MI 48201, USA Y1 - 2001 PY - 2001 DA - 2001 SP - 2493 EP - 2502 VL - 55 IS - 12 SN - 0014-3820, 0014-3820 KW - Diptera KW - covariance KW - Animal Behavior Abstracts; Ecology Abstracts; Entomology Abstracts KW - Survival KW - Feeding behavior KW - Lipid metabolism KW - Fecundity KW - Life history KW - Drosophila melanogaster KW - Evolution KW - Selection KW - Z 05197:Habits & life histories KW - Y 25493:Insects KW - D 04659:Insects KW - Z 05199:Feeding KW - Z 05220:General KW - Y 25523:Insects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18284710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Evolution&rft.atitle=The+effects+of+selection+for+larval+behavior+on+adult+life-history+features+in+Drosophila+melanogaster&rft.au=Foley%2C+P+A%3BLuckinbill%2C+L+S&rft.aulast=Foley&rft.aufirst=P&rft.date=2001-01-01&rft.volume=55&rft.issue=12&rft.spage=2493&rft.isbn=&rft.btitle=&rft.title=Evolution&rft.issn=00143820&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Drosophila melanogaster; Feeding behavior; Selection; Evolution; Life history; Fecundity; Survival; Lipid metabolism ER - TY - JOUR T1 - Sports dermatology AN - 18143034; 5163421 AB - Sports-related skin disorders are among the most common ailments affecting adolescent athletes and may significantly impact their performance and that of their team. These conditions may be due to infection, sun exposure, trauma, inflammation or chemical changes. Knowledge of the various disorders and their unique presentations are paramount to the caring for athletes. When making decisions regarding treatment, the clinician should consider the implications for both the individual athlete and the team. JF - Adolescent Medicine AU - Adams, B B AD - Department of Dermatology, University of Cincinnati College of Medicine and Veterans Administration Medical Center, Ohio 45267-0592, USA Y1 - 2001 PY - 2001 DA - 2001 SP - 305 EP - 322 VL - 12 IS - 2 SN - 1041-3499, 1041-3499 KW - Physical Education Index KW - Skin KW - Diseases KW - Infection KW - Sports (safety) KW - Athletes KW - PE 040:Sports & Athletics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18143034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Adolescent+Medicine&rft.atitle=Sports+dermatology&rft.au=Adams%2C+B+B&rft.aulast=Adams&rft.aufirst=B&rft.date=2001-01-01&rft.volume=12&rft.issue=2&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Adolescent+Medicine&rft.issn=10413499&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Skin; Sports (safety); Diseases; Infection; Athletes ER - TY - CPAPER T1 - Regulation of the calcium receptor mRNA levels during keratinocyte differentiation AN - 42265376; 3170453 AU - Ratnam, A AU - Bikle, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42265376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulation+of+the+calcium+receptor+mRNA+levels+during+keratinocyte+differentiation&rft.au=Ratnam%2C+A%3BBikle%2C+D&rft.aulast=Ratnam&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Elsevier Science Publishing Co., 655 Avenue of the Americas, New York, NY 10010, Abstracts available. Paper No. 223 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laser irradiation decreases local recurrence in superficial bladder tumors AN - 42244866; 3154377 AU - Reddy, P P AU - Russell, D J AU - Wilbur, HJ AU - Kaufman, RP Jr AU - Stratton, S S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42244866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Laser+irradiation+decreases+local+recurrence+in+superficial+bladder+tumors&rft.au=Reddy%2C+P+P%3BRussell%2C+D+J%3BWilbur%2C+HJ%3BKaufman%2C+RP+Jr%3BStratton%2C+S+S&rft.aulast=Reddy&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Laser Medicine and Surgery, Inc., 2404 Stewart Square, Wausau, WI 54401, Abstracts available. Price $20 U.S., $30 Foreign. Poster Paper No. 359 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of pruritus: Efficacy of propofol versus sodium thiopental AN - 42226230; 3152898 AU - Melnyk, D L AU - Block, L AU - Harris, L J AU - Cohen, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42226230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Treatment+of+pruritus%3A+Efficacy+of+propofol+versus+sodium+thiopental&rft.au=Melnyk%2C+D+L%3BBlock%2C+L%3BHarris%2C+L+J%3BCohen%2C+S&rft.aulast=Melnyk&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Anesthesia Research Society, 2 Summit Park Drive, Suite 140, Cleveland, OH 44131-2553, Abstracts available. Price $15. Poster Paper No. S-316 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical and molecular pharmacology of adrenergic receptors AN - 42218497; 3152408 AU - Hoffman, B B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42218497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Clinical+and+molecular+pharmacology+of+adrenergic+receptors&rft.au=Hoffman%2C+B+B&rft.aulast=Hoffman&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Phone: (610)825-3838; Fax: (610)834-8652, Selected Abstracts available. Price $8. Audio cassette available from The Hour Recording Co., PO Box 1299, St. Petersburg, FL 33731. Price $10. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accessibility of clinical trial results and overcoming publication bias: Defining the scope of the problem - A clinician and IRB member's view AN - 42215392; 3152276 AU - Lowenthal, D T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42215392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Accessibility+of+clinical+trial+results+and+overcoming+publication+bias%3A+Defining+the+scope+of+the+problem+-+A+clinician+and+IRB+member%27s+view&rft.au=Lowenthal%2C+D+T&rft.aulast=Lowenthal&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Phone: (610)825-3838; Fax: (610)834-8652, Selected Abstracts available. Price $8. Audio cassette available from The Hour Recording Co., PO Box 1299, St. Petersburg, FL 33731. Price $10. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Do saliva concentrations predict plasma concentrations of enoxacin, ciprofloxacin, and theophylline? AN - 42215289; 3152251 AU - Zhai, S AU - Wei, X AU - Parker, B AU - Kunze, K AU - Vestal, R E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42215289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Do+saliva+concentrations+predict+plasma+concentrations+of+enoxacin%2C+ciprofloxacin%2C+and+theophylline%3F&rft.au=Zhai%2C+S%3BWei%2C+X%3BParker%2C+B%3BKunze%2C+K%3BVestal%2C+R+E&rft.aulast=Zhai&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Phone: (610)825-3838; Fax: (610)834-8652, Selected Abstracts available. Price $8. Audio cassette available from The Hour Recording Co., PO Box 1299, St. Petersburg, FL 33731. Price $10. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SNOMED analysis of three years' accessioned cases (40, 124) of a surgical pathology department: Implications for pathology-based demographic studies AN - 42211100; 3141326 AU - Berman, J J AU - Moore, G W AU - Donnelly, W H AU - Massey, J K AU - Craig, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 6500:Mathematics and Computer Science KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42211100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=SNOMED+analysis+of+three+years%27+accessioned+cases+%2840%2C+124%29+of+a+surgical+pathology+department%3A+Implications+for+pathology-based+demographic+studies&rft.au=Berman%2C+J+J%3BMoore%2C+G+W%3BDonnelly%2C+W+H%3BMassey%2C+J+K%3BCraig%2C+B&rft.aulast=Berman&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Medical Informatics Association, 4915 St. Elmo Ave., Suite 302, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacokinetics and pharmacodynamics of imiquimod AN - 42210590; 3152125 AU - Holtzman, J L AU - Finley, D K AU - Imberston, L AU - McCarville, S AU - Miller, R AU - Kvam, D C AU - Horton, V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42210590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pharmacokinetics+and+pharmacodynamics+of+imiquimod&rft.au=Holtzman%2C+J+L%3BFinley%2C+D+K%3BImberston%2C+L%3BMcCarville%2C+S%3BMiller%2C+R%3BKvam%2C+D+C%3BHorton%2C+V&rft.aulast=Holtzman&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Phone: (610)825-3838; Fax: (610)834-8652, Selected Abstracts available. Price $8. Audio cassette available from The Hour Recording Co., PO Box 1299, St. Petersburg, FL 33731. Price $10. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Continuous quality improvement methods: Application for OBRA regulations AN - 42206577; 3138140 AU - DeVito, CA AU - Persily, NA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42206577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Continuous+quality+improvement+methods%3A+Application+for+OBRA+regulations&rft.au=DeVito%2C+CA%3BPersily%2C+NA&rft.aulast=DeVito&rft.aufirst=CA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Public Health Association, Publication Sales, 1015 15th St., NW, Washington, DC 20005, USA, Abstracts available. Price $30 for 2-volume set. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural modeling of human procathepsin AN - 42206307; 3131317 AU - Sachdev, D AU - Schorey, J S AU - Lueke, H AU - Quiocho, F AU - Chirgwin, J M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42206307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Structural+modeling+of+human+procathepsin&rft.au=Sachdev%2C+D%3BSchorey%2C+J+S%3BLueke%2C+H%3BQuiocho%2C+F%3BChirgwin%2C+J+M&rft.aulast=Sachdev&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Cancer Therapy & Research Center, 8122 Datapoint Drive, Suite 600, San Antonio, TX 78229, USA. Fax: (512) 694-5221. Poster Paper No. 211 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV illness and mental distress in male and female African American clients of AIDS care and referral centers AN - 42197947; 3135962 AU - Linn, J G AU - Poku, KA AU - Cain, V A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42197947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=HIV+illness+and+mental+distress+in+male+and+female+African+American+clients+of+AIDS+care+and+referral+centers&rft.au=Linn%2C+J+G%3BPoku%2C+KA%3BCain%2C+V+A&rft.aulast=Linn&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Public Health Association, Publication Sales, 1015 15th St., NW, Washington, DC 20005, USA, Abstracts available. Price $30 for 2-volume set. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HBP1, a novel high mobility group protein, enhances myeloperoxidase promoter activity in developing myeloid cells AN - 41528182; 3431400 AU - Austin, GE AU - Lu, J-P AU - Zhao, W-G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41528182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=HBP1%2C+a+novel+high+mobility+group+protein%2C+enhances+myeloperoxidase+promoter+activity+in+developing+myeloid+cells&rft.au=Austin%2C+GE%3BLu%2C+J-P%3BZhao%2C+W-G&rft.aulast=Austin&rft.aufirst=GE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: W.B. Saunders Co., P.O. Box 628239, Orlando, FL 32862-8239, USA; phone: (800) 654-2452; fax: (800) 225-6030; email: wbspcs@harcourtbrave.com; URL: customerservice.wbsaunders.com, Abstracts available. Contact W.B. Saunders for price. Poster Paper No. 778 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurosphilis case report: Dominance of vasculitis over meningoencephalitis in determining clinical findings AN - 41511209; 3421185 AU - Masaryk, A M AU - Labadie, EL Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41511209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neurosphilis+case+report%3A+Dominance+of+vasculitis+over+meningoencephalitis+in+determining+clinical+findings&rft.au=Masaryk%2C+A+M%3BLabadie%2C+EL&rft.aulast=Masaryk&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Western Neuroradiological Society (WNS), 2210 Midwest Road, Suite 207, Oak Brook, IL 60523-8205, USA; phone: (630) 574-0220; fax: (630) 574-0661; email: asnradmn@interaccess.com, Abtracts available. Contact WNS for price. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spectrum of molecular defects in the erythroid 5-aminolevulinate synthase gene in hereditary sideroblastic anemia AN - 41493527; 3433377 AU - Bottomley, S S AU - Wise, P D AU - Wasson, E G AU - Carpenter, N J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41493527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Spectrum+of+molecular+defects+in+the+erythroid+5-aminolevulinate+synthase+gene+in+hereditary+sideroblastic+anemia&rft.au=Bottomley%2C+S+S%3BWise%2C+P+D%3BWasson%2C+E+G%3BCarpenter%2C+N+J&rft.aulast=Bottomley&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: W.B. Saunders Co., P.O. Box 628239, Orlando, FL 32862-8239, USA; phone: (800) 654-2452; fax: (800) 225-6030; email: wbspcs@harcourtbrave.com; URL: customerservice.wbsaunders.com, Abstracts available. Contact W.B. Saunders for price. Poster Paper No. 2758 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Receipt of prevention services by veterans using VHA versus non-VHA facilities AN - 41407435; 3372950 AU - Rabiner, D J AU - Branch, L G AU - Sullivan, RJ Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41407435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Receipt+of+prevention+services+by+veterans+using+VHA+versus+non-VHA+facilities&rft.au=Rabiner%2C+D+J%3BBranch%2C+L+G%3BSullivan%2C+RJ+Jr&rft.aulast=Rabiner&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Association of Teachers of Preventive Medicine, 1660 L Street NW, Suite 206, Washington, D.C. 20036, USA, Abstracts available. Price $10. Poster Paper No. PS 79 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Predicting anesthetic depth using electroencephalogram and models of drug interaction AN - 41293864; 3301510 AU - Hu, C AU - Greenwald, S AU - Chamoun, N AU - Shafer, S L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41293864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Predicting+anesthetic+depth+using+electroencephalogram+and+models+of+drug+interaction&rft.au=Hu%2C+C%3BGreenwald%2C+S%3BChamoun%2C+N%3BShafer%2C+S+L&rft.aulast=Hu&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Absorption pharmacokinetics of tacrolimus in renal transplant candidates AN - 41293598; 3301432 AU - Pak, W B AU - Lum, B L AU - Cooney, G F AU - Heifets, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41293598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Absorption+pharmacokinetics+of+tacrolimus+in+renal+transplant+candidates&rft.au=Pak%2C+W+B%3BLum%2C+B+L%3BCooney%2C+G+F%3BHeifets%2C+M&rft.aulast=Pak&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of intraperitoneal administration of methylprednisolone on pain perception in rats AN - 41284516; 3310636 AU - Donovan, K L AU - Murarescu, B M AU - Franks, W T AU - Horn, J-L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 3500:Clinical Medicine KW - U 7500:Pharmacology KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41284516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+intraperitoneal+administration+of+methylprednisolone+on+pain+perception+in+rats&rft.au=Donovan%2C+K+L%3BMurarescu%2C+B+M%3BFranks%2C+W+T%3BHorn%2C+J-L&rft.aulast=Donovan&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Anesthesia Research Society, 2 Summit Park Drive, Suite 140, Cleveland, OH 44131, Abstracts available. Paper No. S290 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Efficacy of epidural steroids in chronic low back pain patients with and without electrodiagnostic evidence of a lumbosacral radiculopathy AN - 41263954; 3286367 AU - Welsh, JE AU - Date, E S AU - Ngo, Duc T AU - Lewetzon, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41263954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Efficacy+of+epidural+steroids+in+chronic+low+back+pain+patients+with+and+without+electrodiagnostic+evidence+of+a+lumbosacral+radiculopathy&rft.au=Welsh%2C+JE%3BDate%2C+E+S%3BNgo%2C+Duc+T%3BLewetzon%2C+C&rft.aulast=Welsh&rft.aufirst=JE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Academy of Physical Medicine and Rehabilitation, 1 IBM Plaza, Suite 2500, Chicago, IL 60611, Abstracts available. Poster Paper No. 58 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Long-term application of transcutaneous electrical nerve stimulation in patients with newer pacemakers AN - 41222604; 3286510 AU - Hariman, L AU - Satcher, S M AU - Subbarao, JVS AU - Hariman, R J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41222604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Long-term+application+of+transcutaneous+electrical+nerve+stimulation+in+patients+with+newer+pacemakers&rft.au=Hariman%2C+L%3BSatcher%2C+S+M%3BSubbarao%2C+JVS%3BHariman%2C+R+J&rft.aulast=Hariman&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Academy of Physical Medicine and Rehabilitation, 1 IBM Plaza, Suite 2500, Chicago, IL 60611, Abstracts available. Poster Paper No. 201 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Parathyroid hormone (PTH) regulates the expression of the sodium-phosphate cotransporter (NaPi-4) in OK cells AN - 41190135; 3248489 AU - Lederer, ED AU - Klein, J B AU - Mathieson, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41190135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Parathyroid+hormone+%28PTH%29+regulates+the+expression+of+the+sodium-phosphate+cotransporter+%28NaPi-4%29+in+OK+cells&rft.au=Lederer%2C+ED%3BKlein%2C+J+B%3BMathieson%2C+J&rft.aulast=Lederer&rft.aufirst=ED&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 2307 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Many faces of pneumocephalus AN - 41171956; 3254403 AU - Healy, J F AU - Fu, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41171956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Many+faces+of+pneumocephalus&rft.au=Healy%2C+J+F%3BFu%2C+K&rft.aulast=Healy&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society of Nearoradiology, 2210 Midwest Road, Suite 207, Oak Brook, IL 60521, Abstracts available. Poster Paper No. SE 53 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytochrome P-450 in vitro activation of cyclophosphamide and ifosfamide AN - 41150235; 3214868 AU - Anthony, L B AU - Bennett, R E AU - Deegan, P M AU - Hande, K R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41150235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cytochrome+P-450+in+vitro+activation+of+cyclophosphamide+and+ifosfamide&rft.au=Anthony%2C+L+B%3BBennett%2C+R+E%3BDeegan%2C+P+M%3BHande%2C+K+R&rft.aulast=Anthony&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High dose megestrol acetate does not alter etoposide clearance AN - 41150204; 3214866 AU - Hande, K AU - Taplin, S AU - Krozely, M AU - Blanke, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41150204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=High+dose+megestrol+acetate+does+not+alter+etoposide+clearance&rft.au=Hande%2C+K%3BTaplin%2C+S%3BKrozely%2C+M%3BBlanke%2C+C&rft.aulast=Hande&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of forskolin-stimulated adenylyl cyclase activity by PD 81,723 AN - 41142497; 3214753 AU - Vestal, R E AU - Musser, B AU - Liu, J AU - Olson, R D AU - Mudumbi, R V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41142497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inhibition+of+forskolin-stimulated+adenylyl+cyclase+activity+by+PD+81%2C723&rft.au=Vestal%2C+R+E%3BMusser%2C+B%3BLiu%2C+J%3BOlson%2C+R+D%3BMudumbi%2C+R+V&rft.aulast=Vestal&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Real-time analysis of monophasic action potential and ECG recordings - A tool for monitoring acute drug effects on cardiac repolarization AN - 41137635; 3214710 AU - Knollmann, B C AU - Woosley, R L AU - Franz, M R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41137635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Real-time+analysis+of+monophasic+action+potential+and+ECG+recordings+-+A+tool+for+monitoring+acute+drug+effects+on+cardiac+repolarization&rft.au=Knollmann%2C+B+C%3BWoosley%2C+R+L%3BFranz%2C+M+R&rft.aulast=Knollmann&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Planning a successful and financially profitable annual workshop AN - 41132759; 3229136 AU - Peckel, J AU - Bogart, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41132759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Planning+a+successful+and+financially+profitable+annual+workshop&rft.au=Peckel%2C+J%3BBogart%2C+K&rft.aulast=Peckel&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Oncology Nursing Society, 501 Holiday Drive, Pittsburgh, PA 15220-2749, Abstracts available. Price $4. Paper No. 111 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased levels of plasma met-enkephalin associated with orthotopic liver transplantation AN - 41130693; 3218674 AU - Donovan, K L AU - Janicki, P K AU - Franks, W T AU - Striepe, VI AU - Pinson, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41130693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Increased+levels+of+plasma+met-enkephalin+associated+with+orthotopic+liver+transplantation&rft.au=Donovan%2C+K+L%3BJanicki%2C+P+K%3BFranks%2C+W+T%3BStriepe%2C+VI%3BPinson%2C+W&rft.aulast=Donovan&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: International Anesthesia Research Society, 2 Summit Park Drive, Suite 140, Cleveland, OH 44131-2553, Abstracts available. Paper No. S95 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Possible role of CYPs 1A1, 1A2 and 2E1 in the initiation of human oropharyngeal, esophageal and gastric cancers AN - 41119287; 3214740 AU - Holtzman, J L AU - Zhou, L X AU - Zheng, W AU - Ganz, R AU - Pihlstrom, B AU - Dansen, V AU - Park, S S AU - Potter, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41119287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Possible+role+of+CYPs+1A1%2C+1A2+and+2E1+in+the+initiation+of+human+oropharyngeal%2C+esophageal+and+gastric+cancers&rft.au=Holtzman%2C+J+L%3BZhou%2C+L+X%3BZheng%2C+W%3BGanz%2C+R%3BPihlstrom%2C+B%3BDansen%2C+V%3BPark%2C+S+S%3BPotter%2C+J&rft.aulast=Holtzman&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Newer chemotherapeutic agents for M. tuberculosis and M. avium complex infections AN - 41071711; 3196042 AU - Cynamon, M H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41071711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Newer+chemotherapeutic+agents+for+M.+tuberculosis+and+M.+avium+complex+infections&rft.au=Cynamon%2C+M+H&rft.aulast=Cynamon&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Pearson Professional, Ltd., Subscriptions Dept., PO Box 77, Harlow, Essex CM19 5BQ, UK, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preparing projections of the veteran population in each county AN - 40860212; 1112902 AU - Russell Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 6500:MATHEMATICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40860212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Preparing+projections+of+the+veteran+population+in+each+county&rft.au=Russell&rft.aulast=Russell&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Statistical Association, 806 15th Street, N.W., Washington, DC 20005 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Initial report on survey of female veterans AN - 40860172; 1112898 AU - Dienstfrey, S J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 6500:MATHEMATICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40860172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Initial+report+on+survey+of+female+veterans&rft.au=Dienstfrey%2C+S+J&rft.aulast=Dienstfrey&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Statistical Association, 806 15th Street, N.W., Washington, DC 20005 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Log-linear model for the hospitalization of veterans aged 55 and over AN - 40858724; 1112892 AU - Stockford, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 6500:MATHEMATICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40858724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Log-linear+model+for+the+hospitalization+of+veterans+aged+55+and+over&rft.au=Stockford%2C+D&rft.aulast=Stockford&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Statistical Association, 806 15th Street, N.W., Washington, DC 20005 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determinants of VA Hospital usage by aging veterans AN - 40857243; 1112883 AU - Peden, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 6500:MATHEMATICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Determinants+of+VA+Hospital+usage+by+aging+veterans&rft.au=Peden%2C+A&rft.aulast=Peden&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Statistical Association, 806 15th Street, N.W., Washington, DC 20005 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measuring hospital productivity using econometric techniques AN - 40854227; 1112914 AU - Krim, J C AU - Tsou, V T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 6500:MATHEMATICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40854227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Measuring+hospital+productivity+using+econometric+techniques&rft.au=Krim%2C+J+C%3BTsou%2C+V+T&rft.aulast=Krim&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Statistical Association, 806 15th Street, N.W., Washington, DC 20005 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of aging on the febrile response AN - 40824059; 1077914 AU - Kauffman, CA AU - Tocco-Bradley, R AU - Kluger, MJ Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40824059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+aging+on+the+febrile+response&rft.au=Kauffman%2C+CA%3BTocco-Bradley%2C+R%3BKluger%2C+MJ&rft.aulast=Kauffman&rft.aufirst=CA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Journal of Leukocyte Biology, Alan R. Liss, Inc., 41 East 11th Street, New York, NY 10003, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ultrafiltration hemodynamics in conscious dogs: effect of extracorporeal blood temperature AN - 40558356; 0499027 AU - Daugirdas, J T AU - Ing, T S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40558356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ultrafiltration+hemodynamics+in+conscious+dogs%3A+effect+of+extracorporeal+blood+temperature&rft.au=Daugirdas%2C+J+T%3BIng%2C+T+S&rft.aulast=Daugirdas&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Proceedings in: ASAIO Transactions, Sep. 1983, ASAIO Transactions Office, P.O. Box 5028, Alexandria, VA 22305, USA, Abstracts booklet (vol. 12) also available from Transactions Office for $7.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Calcium-Phosphorus Interactions in Man AN - 40448620; 0244245 AU - Spencer, H AU - Kramer, L AU - Osis, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40448620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Calcium-Phosphorus+Interactions+in+Man&rft.au=Spencer%2C+H%3BKramer%2C+L%3BOsis%2C+D&rft.aulast=Spencer&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: Journal of Nutrition, Jun. 1982, Journal of Nutrition, Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20814, ISSN: 0022-3166; Price: $8.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Ornithine Decarboxylase in Compensatory Lung Growth AN - 40446930; 0210216 AU - Thet, LA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40446930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+Ornithine+Decarboxylase+in+Compensatory+Lung+Growth&rft.au=Thet%2C+LA&rft.aulast=Thet&rft.aufirst=LA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neutrophil Alkaline Phosphatase in Zinc Deficiency and its Response to Infection AN - 40442059; 0209236 AU - Lewkow, L M AU - Prasad, A S AU - Koniuch, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40442059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neutrophil+Alkaline+Phosphatase+in+Zinc+Deficiency+and+its+Response+to+Infection&rft.au=Lewkow%2C+L+M%3BPrasad%2C+A+S%3BKoniuch%2C+D&rft.aulast=Lewkow&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pulmonary Vascular Response to Intravascular Pneumococcal Challenge in Dogs AN - 40435784; 0180161 AU - Chick, T W AU - Goldblum, SE AU - Smith, N D AU - Butler, C AU - Reed, W P AU - Skipper, B E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40435784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pulmonary+Vascular+Response+to+Intravascular+Pneumococcal+Challenge+in+Dogs&rft.au=Chick%2C+T+W%3BGoldblum%2C+SE%3BSmith%2C+N+D%3BButler%2C+C%3BReed%2C+W+P%3BSkipper%2C+B+E&rft.aulast=Chick&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Response to Intradermal Human PPD, Avian PPD and Six Recall Antigens in a Nursing Home Population AN - 40430772; 0177326 AU - Cohn, J R AU - Buckley, CE AU - Hohl, C AU - Tyson, G AU - Neish, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40430772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Response+to+Intradermal+Human+PPD%2C+Avian+PPD+and+Six+Recall+Antigens+in+a+Nursing+Home+Population&rft.au=Cohn%2C+J+R%3BBuckley%2C+CE%3BHohl%2C+C%3BTyson%2C+G%3BNeish%2C+D&rft.aulast=Cohn&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms of Arterial Hypoxemia During Rapid Movement Sleep in Patients With COPD AN - 40430265; 0178717 AU - Fletcher, E C AU - Gray, BA AU - Levin, D C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40430265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mechanisms+of+Arterial+Hypoxemia+During+Rapid+Movement+Sleep+in+Patients+With+COPD&rft.au=Fletcher%2C+E+C%3BGray%2C+BA%3BLevin%2C+D+C&rft.aulast=Fletcher&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Profile of Airway Cells in Rats Following Systemic Endotoxemia AN - 40427626; 0179408 AU - Chang, J AU - Lesser, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40427626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Profile+of+Airway+Cells+in+Rats+Following+Systemic+Endotoxemia&rft.au=Chang%2C+J%3BLesser%2C+M&rft.aulast=Chang&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mycobacterium Simiae: Clinical Features and Follow-Up of 24 Patients AN - 40427014; 0177309 AU - Bell, R C AU - Higuchi, J H AU - Donovan, W N AU - Krasnow, I AU - Johanson, W G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40427014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mycobacterium+Simiae%3A+Clinical+Features+and+Follow-Up+of+24+Patients&rft.au=Bell%2C+R+C%3BHiguchi%2C+J+H%3BDonovan%2C+W+N%3BKrasnow%2C+I%3BJohanson%2C+W+G&rft.aulast=Bell&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bacteremia Due to Streptococcus pneumoniae of Non-Vaccine Serotypes AN - 40426976; 0177232 AU - Shlaes, DM AU - Spagnuolo, P J AU - Mandell, R AU - Bass, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40426976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Bacteremia+Due+to+Streptococcus+pneumoniae+of+Non-Vaccine+Serotypes&rft.au=Shlaes%2C+DM%3BSpagnuolo%2C+P+J%3BMandell%2C+R%3BBass%2C+S&rft.aulast=Shlaes&rft.aufirst=DM&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence of a Circulating Factor in Cigarette Smoke Which Injures Epithelial Cells AN - 40426728; 0176891 AU - Merrill, W W AU - Shrader, C AU - Matthay, R A AU - Strober, W AU - Niederman, M AU - Reynolds, HY Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40426728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evidence+of+a+Circulating+Factor+in+Cigarette+Smoke+Which+Injures+Epithelial+Cells&rft.au=Merrill%2C+W+W%3BShrader%2C+C%3BMatthay%2C+R+A%3BStrober%2C+W%3BNiederman%2C+M%3BReynolds%2C+HY&rft.aulast=Merrill&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Retention of Intact Cells on Bronchoscopy Brushes After Conventional Cleaning AN - 40425268; 0176124 AU - Baker, R W AU - Jennings, C D AU - Powell, R D AU - Rehm Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40425268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Retention+of+Intact+Cells+on+Bronchoscopy+Brushes+After+Conventional+Cleaning&rft.au=Baker%2C+R+W%3BJennings%2C+C+D%3BPowell%2C+R+D%3BRehm&rft.aulast=Baker&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - "Thick" and "Thin" Alveolap Epithelial Partitions in the Adult Human Lung AN - 40425046; 0178839 AU - Takaro, T AU - Gaddy, L AU - Parra, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40425046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=%22Thick%22+and+%22Thin%22+Alveolap+Epithelial+Partitions+in+the+Adult+Human+Lung&rft.au=Takaro%2C+T%3BGaddy%2C+L%3BParra%2C+S&rft.aulast=Takaro&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stimulation of Fibroblast Proliferation by Human Interleukin 1 AN - 40424402; 0175387 AU - Postlethwaite, A E AU - Lachman, L B AU - Kang, AH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40424402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Stimulation+of+Fibroblast+Proliferation+by+Human+Interleukin+1&rft.au=Postlethwaite%2C+A+E%3BLachman%2C+L+B%3BKang%2C+AH&rft.aulast=Postlethwaite&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: Arthritis and Rheumatism, Apr. 1982, Arthritis Foundation, 3400 Peachtree Rd. N.E., Atlanta, GA 30326, Abstract No. 146 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cognitive Behavior Modification for Chronic Pain Management: An Outpatient Couples Group Approach AN - 40422511; 0186649 AU - Chaney, E F AU - Moore, JE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40422511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cognitive+Behavior+Modification+for+Chronic+Pain+Management%3A+An+Outpatient+Couples+Group+Approach&rft.au=Chaney%2C+E+F%3BMoore%2C+JE&rft.aulast=Chaney&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Behavioral Medicine National Office, P.O. Box 8530, University Station, Knoxville, TN 37996, Abstracts booklet and cassette tapes available Abstract No. B46 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Cognitive-Behavioral Strategies in the Maintenance of Exercise AN - 40421830; 0186508 AU - Dubbert, P M AU - Martin, JE AU - Raczynski, J AU - Sikora, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40421830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+Cognitive-Behavioral+Strategies+in+the+Maintenance+of+Exercise&rft.au=Dubbert%2C+P+M%3BMartin%2C+JE%3BRaczynski%2C+J%3BSikora%2C+T&rft.aulast=Dubbert&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Behavioral Medicine National Office, P.O. Box 8530, University Station, Knoxville, TN 37996, Abstracts booklet and cassette tapes available Abstract No. A15 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Persistence and Movement of Phenoxy Herbicides and TCDD in Sites Previously Used for the Long-Term Storage of Herbicide Orange AN - 40421211; 0163800 AU - Young, AL AU - Cairney, W J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40421211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Persistence+and+Movement+of+Phenoxy+Herbicides+and+TCDD+in+Sites+Previously+Used+for+the+Long-Term+Storage+of+Herbicide+Orange&rft.au=Young%2C+AL%3BCairney%2C+W+J&rft.aulast=Young&rft.aufirst=AL&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Abstracts available: Weed Science Society of America, Claude Cruse, Executive Secretary, 309 West Cark St., Champaign, IL 61820, Abstract No. 195 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Right Ventricular Ejection Fraction in Patients With Chronic Obstructive Lung Disease Using Xe-133: A Comparison With Tc-99m by Gated First-Pass Radionuclide Angiography AN - 40419888; 0175159 AU - Hooper, W AU - Nelson, T AU - Slutsky, R AU - Peters, J AU - Moser, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40419888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evaluation+of+Right+Ventricular+Ejection+Fraction+in+Patients+With+Chronic+Obstructive+Lung+Disease+Using+Xe-133%3A+A+Comparison+With+Tc-99m+by+Gated+First-Pass+Radionuclide+Angiography&rft.au=Hooper%2C+W%3BNelson%2C+T%3BSlutsky%2C+R%3BPeters%2C+J%3BMoser%2C+K&rft.aulast=Hooper&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical Course and Outcome of Lupus Nephritis as Related to Morphologic Forms in Children and Adults AN - 40418910; 0177660 AU - Al-Rawi, Z S AU - Altman, R D AU - Pardo, V AU - Perez-Stable, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40418910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Clinical+Course+and+Outcome+of+Lupus+Nephritis+as+Related+to+Morphologic+Forms+in+Children+and+Adults&rft.au=Al-Rawi%2C+Z+S%3BAltman%2C+R+D%3BPardo%2C+V%3BPerez-Stable%2C+E&rft.aulast=Al-Rawi&rft.aufirst=Z&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: Arthritis and Rheumatism, Apr. 1982, Arthritis Foundation, 3400 Peachtree Rd. N.E., Atlanta, GA 30326, Abstract No. A92 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hemodynamics of Patients With Severe Chronic Obstructive Pulmonary Disease (COPD) During Progressive Upright Exercise AN - 40418700; 0175166 AU - Mintz, H M AU - Linden, G S AU - Brown, SE AU - Light, R W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40418700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Hemodynamics+of+Patients+With+Severe+Chronic+Obstructive+Pulmonary+Disease+%28COPD%29+During+Progressive+Upright+Exercise&rft.au=Mintz%2C+H+M%3BLinden%2C+G+S%3BBrown%2C+SE%3BLight%2C+R+W&rft.aulast=Mintz&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lung Fibrosis and Emphysema: Divergent Responses to a Common Injury? AN - 40417954; 0178040 AU - Niewoehner, DE AU - Hoidal, J R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40417954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Lung+Fibrosis+and+Emphysema%3A+Divergent+Responses+to+a+Common+Injury%3F&rft.au=Niewoehner%2C+DE%3BHoidal%2C+J+R&rft.aulast=Niewoehner&rft.aufirst=DE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Radiation Controlled Focal Pharmacology in the Therapy of Experimental Epilepsy AN - 40415498; 0141449 AU - Remler, M P AU - Marcussen, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40415498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Radiation+Controlled+Focal+Pharmacology+in+the+Therapy+of+Experimental+Epilepsy&rft.au=Remler%2C+M+P%3BMarcussen%2C+W&rft.aulast=Remler&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 29.17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cathepsin B and Prolyl Endopeptidase Levels in Rat Pulmonary Macrophages: Comparison With Levels in Baseline and Stimulated Peritoneal Macrophages AN - 40412034; 0174757 AU - Lesser, M AU - Chang, J AU - Orlowski, J AU - Kilburn, KH AU - Orlowski, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40412034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cathepsin+B+and+Prolyl+Endopeptidase+Levels+in+Rat+Pulmonary+Macrophages%3A+Comparison+With+Levels+in+Baseline+and+Stimulated+Peritoneal+Macrophages&rft.au=Lesser%2C+M%3BChang%2C+J%3BOrlowski%2C+J%3BKilburn%2C+KH%3BOrlowski%2C+M&rft.aulast=Lesser&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acute Tubular Necrosis in Hepatorenal Syndrome: An Electron Microscopic Study AN - 40411422; 0142498 AU - Mandal, A K AU - Lansing, M AU - Fahmy, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40411422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Acute+Tubular+Necrosis+in+Hepatorenal+Syndrome%3A+An+Electron+Microscopic+Study&rft.au=Mandal%2C+A+K%3BLansing%2C+M%3BFahmy%2C+A&rft.aulast=Mandal&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Abstracts booklet available: American Society of Clinical Pathologists, 2100 West Harrison St., Chicago, IL 60612, Abstract No. 20 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Extracellular Potassium on the Excitability of the Parallel Fibers AN - 40410206; 0141099 AU - Malenka, R C AU - Kocsis, J D AU - Waxman, S G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40410206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+Extracellular+Potassium+on+the+Excitability+of+the+Parallel+Fibers&rft.au=Malenka%2C+R+C%3BKocsis%2C+J+D%3BWaxman%2C+S+G&rft.aulast=Malenka&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 26.7 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Behavioral States After Brainstem Transection at the Medullary Level AN - 40408904; 0143736 AU - Siegel, J M AU - Nienhuis, R AU - Tomaszewski, K AU - Wheeler, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40408904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Behavioral+States+After+Brainstem+Transection+at+the+Medullary+Level&rft.au=Siegel%2C+J+M%3BNienhuis%2C+R%3BTomaszewski%2C+K%3BWheeler%2C+R&rft.aulast=Siegel&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 79.2 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Direct Immunofluorescence Staining of Sputum for Legionelle pneumophila AN - 40407221; 0142246 AU - Renner, ED AU - Lattimer, G L AU - Zimmerman, J C AU - Tseng, CH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40407221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Direct+Immunofluorescence+Staining+of+Sputum+for+Legionelle+pneumophila&rft.au=Renner%2C+ED%3BLattimer%2C+G+L%3BZimmerman%2C+J+C%3BTseng%2C+CH&rft.aulast=Renner&rft.aufirst=ED&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Abstracts booklet available: American Society of Clinical Pathologists, 2100 West Harrison St., Chicago, IL 60612, Abstract No. P-19 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Autofluorescence of Fungi: an Aid to Detection in Tissue Sections AN - 40404058; 0142335 AU - Mann, J L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40404058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Autofluorescence+of+Fungi%3A+an+Aid+to+Detection+in+Tissue+Sections&rft.au=Mann%2C+J+L&rft.aulast=Mann&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Abstracts booklet available: American Society of Clinical Pathologists, 2100 West Harrison St., Chicago, IL 60612, Abstract No. P-34 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of unsaturated fatty acids on lipoprotein oxidation and induction of proinflammatory responses AN - 39260352; 3524093 AU - Reaven, P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39260352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+unsaturated+fatty+acids+on+lipoprotein+oxidation+and+induction+of+proinflammatory+responses&rft.au=Reaven%2C+P&rft.aulast=Reaven&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Oil Chemists' Society, AOCS Meetings and Exhibits Department, P.O. Box 3489, Champaign, Il 61826-3489, USA; phone: 1-217-359-2344; fax: 1-217-351-8091; email: meetings@aocs.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Chronic ethanol exposure - Comparisons of human and experimental data AN - 39188274; 3525808 AU - Cook, R T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39188274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Chronic+ethanol+exposure+-+Comparisons+of+human+and+experimental+data&rft.au=Cook%2C+R+T&rft.aulast=Cook&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Peroxidase activity of the extracellular superoxide dismutase AN - 39149953; 3516996 AU - Hink, U AU - Fukai, T AU - Wendt, M AU - Parthasarathy, S AU - Harrison, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39149953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Peroxidase+activity+of+the+extracellular+superoxide+dismutase&rft.au=Hink%2C+U%3BFukai%2C+T%3BWendt%2C+M%3BParthasarathy%2C+S%3BHarrison%2C+D&rft.aulast=Hink&rft.aufirst=U&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Elsevier Science, Inc., 655 Avenue of the Americas, New York, NY 10010-5107; phone: 212-633-3730; fax: 212-633-3680; email: usinfo-f@elsevier.com; URL: www.elsevier.com, Full Abstracts Available. N1 - Last updated - 2011-10-26 ER - TY - JOUR T1 - Dimerization interfaces of v-erbA homodimers and heterodimers with retinoid X receptor alpha. AN - 72477831; 11018031 AB - The oncoprotein v-ErbA, a member of the zinc finger transcription factor superfamily, is a mutated version of thyroid hormone receptor alpha1 that is virtually incapable of binding T3. v-ErbA and other members of this family can bind as homodimers and heterodimers with retinoid X receptors to specific DNA sequences arranged as direct, inverted, or everted repeats. At least two regions in the C-terminal domain, the I box (10 and 11 helices in v-ErbA and thyroid hormone receptors) and the 20-amino acid region are involved in dimerization. However, it has not been entirely understood how these receptors dimerize on differently oriented core motifs and whether the domain(s) responsible for homodimerization and heterodimerization are identical. Therefore, deletions of the entire 20-amino acid region, the 10 helix, the 11 helix, and point mutations within these regions of v-ErbA were made by site-directed mutagenesis. The mutant proteins were tested for their ability to form v-ErbA homodimers and heterodimers with retinoid X receptor alpha on differently oriented core motifs by electrophoretic mobility shift assay. Transient transfections were performed to determine the dominant negative activity of the v-ErbA mutants. The data indicate that different dimerization interfaces are used for v-ErbA homodimerization and heterodimerization with retinoid X receptor alpha, and different dimerization interfaces are used on differently oriented core motifs. The data are of general interest because the information improves our understanding of the role of these dimerization interfaces in the mechanism of action not only of v-ErbA but also of other members of the superfamily. JF - The Journal of biological chemistry AU - Shen, Q AU - Subauste, J S AD - Division of Endocrinology and Metabolism, University of Mississippi Medical Center and G. V. Montgomery Veterans Administration Medical Center, Jackson, Mississippi 39216, USA. Y1 - 2000/12/29/ PY - 2000 DA - 2000 Dec 29 SP - 41018 EP - 41027 VL - 275 IS - 52 SN - 0021-9258, 0021-9258 KW - Oncogene Proteins v-erbA KW - 0 KW - Receptors, Retinoic Acid KW - Retinoid X Receptors KW - Transcription Factors KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Protein Structure, Secondary KW - Dimerization KW - DNA -- metabolism KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Response Elements KW - Oncogene Proteins v-erbA -- chemistry KW - Receptors, Retinoic Acid -- chemistry KW - Transcription Factors -- chemistry KW - Oncogene Proteins v-erbA -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72477831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Dimerization+interfaces+of+v-erbA+homodimers+and+heterodimers+with+retinoid+X+receptor+alpha.&rft.au=Shen%2C+Q%3BSubauste%2C+J+S&rft.aulast=Shen&rft.aufirst=Q&rft.date=2000-12-29&rft.volume=275&rft.issue=52&rft.spage=41018&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-26 N1 - Date created - 2001-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reemergence of tardive dyskinesia after discontinuation of clozapine treatment. AN - 72483253; 11120422 AB - Tardive dyskinesia (TD) continues to be a significant health problem and a serious limitation to neuroleptic medication treatment. Clozapine treatment may reduce the severity of TD but it is unclear wether the medication temporarily suppresses symptoms or leads to a sustain resolution of the disorder. Herein we describe two cases with severe TD which clozapine had to be discontinued. These cases suggest that clozapine provides a temporary suppression of TD rather than a permanent resolution of the disorder. JF - Schizophrenia research AU - Yovtcheva, S P AU - Stanley-Tilt, C AU - Moles, J K AD - University of Virginia School of Medicine, Roanoke Salem Psychiatric Medicine Residency Program, Department of Psychiatry (116A7), VA Medical Center, Salem, VA 24153, USA. yovtcheva.sonia_r@salem.va.gov Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 107 EP - 109 VL - 46 IS - 2-3 SN - 0920-9964, 0920-9964 KW - Serotonin Antagonists KW - 0 KW - Clozapine KW - J60AR2IKIC KW - Index Medicus KW - Severity of Illness Index KW - Humans KW - Aged KW - Middle Aged KW - Time Factors KW - Recurrence KW - Male KW - Serotonin Antagonists -- therapeutic use KW - Clozapine -- therapeutic use KW - Dyskinesia, Drug-Induced -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72483253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+research&rft.atitle=Reemergence+of+tardive+dyskinesia+after+discontinuation+of+clozapine+treatment.&rft.au=Yovtcheva%2C+S+P%3BStanley-Tilt%2C+C%3BMoles%2C+J+K&rft.aulast=Yovtcheva&rft.aufirst=S&rft.date=2000-12-15&rft.volume=46&rft.issue=2-3&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+research&rft.issn=09209964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-02 N1 - Date created - 2001-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neoadjuvant therapy for organ preservation in head and neck cancer. AN - 85357095; pmid-11129024 AB - OBJECTIVES/HYPOTHESIS: We designed two sequential trials of induction chemotherapy followed by definitive radiation in patients with potentially resectable head and neck cancer to determine whether organ preservation is feasible without apparent compromise of survival Study Design Both trials were Phase II studies. METHODS: Two clinical trials were conducted sequentially at the University of Michigan. Fifty-two patients enrolled in the first study and were treated with a planned three cycles of carboplatin and 5-fluorouracil. Patients who achieved at least 50% reduction in the size of the primary tumor received definitive radiation therapy, to a dose of 6600 to 7380 cGy. Patients with minimal response or progression had immediate salvage surgery. Thirty-seven patients enrolled in the second trial, in which the chemotherapy consisted of carboplatin, 5-fluororuracil, and leukovorin. Responders were treated with accelerated radiation therapy, to a total dose of 7120 cGy delivered in 41 fractions over 5.5 weeks. RESULTS: Toxicity and response were similar in both trials; therefore, the results are reported first separately and then combined for all 89 patients. Tumor sites included: oropharynx, 55 patients; hypopharynx, 34 patients. Eighty-three percent of patients tolerated all three cycles of chemotherapy and toxicity was mild. Response to chemotherapy was: 48% complete response at the primary tumor site, and 34% partial response at the primary tumor site. Initial organ preservation at individual tumor sites was: oropharynx, 58%; hypopharynx, 59%. Median survival was 28 months, and survival at 3 and 5 years was 40% and 24%, respectively. CONCLUSIONS: These two regimens were well tolerated, and survival did not appear to be compromised by organ preservation treatment compared with historical controls. This approach warrants further investigation, particularly in those patients for whom surgery could be functionally debilitating. JF - The Laryngoscope AU - Urba, S G AU - Wolf, G T AU - Bradford, C R AU - Thornton, A F AU - Eisbruch, A AU - Terrell, J E AU - Carpenter, V AU - Miller, T AU - Tang, G AU - Strawderman, M AD - Department of Internal Medicine, University of Michigan Comprehensive Cancer Center and Veterans Administration Medical Center, Ann Arbor, 48109-0922, USA. surba@umich.edu Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 2074 EP - 2080 VL - 110 IS - 12 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Disease-Free Survival KW - Humans KW - Aged KW - Carboplatin -- therapeutic use KW - Fluorouracil -- therapeutic use KW - Aged, 80 and over KW - Radiotherapy Dosage KW - Adult KW - Middle Aged KW - Female KW - Male KW - Chemotherapy, Adjuvant KW - Survival Analysis KW - Leucovorin -- therapeutic use KW - Oropharyngeal Neoplasms -- surgery KW - Oropharyngeal Neoplasms -- radiotherapy KW - Hypopharyngeal Neoplasms -- surgery KW - Carcinoma, Squamous Cell -- mortality KW - Oropharyngeal Neoplasms -- mortality KW - Carcinoma, Squamous Cell -- surgery KW - Oropharyngeal Neoplasms -- drug therapy KW - Hypopharyngeal Neoplasms -- drug therapy KW - Hypopharyngeal Neoplasms -- mortality KW - Hypopharyngeal Neoplasms -- radiotherapy KW - Antineoplastic Agents -- therapeutic use KW - Carcinoma, Squamous Cell -- drug therapy KW - Carcinoma, Squamous Cell -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85357095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Neoadjuvant+therapy+for+organ+preservation+in+head+and+neck+cancer.&rft.au=Urba%2C+S+G%3BWolf%2C+G+T%3BBradford%2C+C+R%3BThornton%2C+A+F%3BEisbruch%2C+A%3BTerrell%2C+J+E%3BCarpenter%2C+V%3BMiller%2C+T%3BTang%2C+G%3BStrawderman%2C+M&rft.aulast=Urba&rft.aufirst=S&rft.date=2000-12-01&rft.volume=110&rft.issue=12&rft.spage=2074&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Gastric-juice ammonia assay for diagnosis of Helicobacter pylori infection and the relationship of ammonia concentration to gastritis severity. AN - 85353398; pmid-11151868 AB - OBJECTIVES: To determine the test characteristics of gastric-juice ammonia concentration as measured by an ion-selective electrode and a rapid ammonia detection device for the diagnosis of Helicobacter pylori infection and to assess the relationship between gastric-juice ammonia concentration and the severity of gastritis. METHODS: Patients undergoing upper endoscopy had collection of gastric juice that was tested for ammonia using an ion-selective electrode and a rapid ammonia assay device that uses a pH-indicating membrane. A receiver operating characteristic curve was calculated for ammonia concentration. Severity of gastritis was graded using the Sydney classification (1) and correlated to gastric-juice ammonia concentration. Patients also underwent H. pylori testing by IgG serology, rapid urease testing, and histological special stain. Ammonia testing results were compared with a reference standard of two of three positive tests and with a second reference standard of a positive serology. RESULTS: 73 patients underwent endoscopy and collection of gastric juice. The receiver operating characteristic curve indicated an optimal cutoff value of 5 mM, yielding a sensitivity of 67%, specificity of 93%, positive predictive value of 67%, and negative predictive value of 93% (compared with the combined reference standard). The rapid NH3-testing device yielded a sensitivity of 83%, specificity 63%, positive predictive value 31%, and negative predictive value 95%. The severity of neutrophilic (p = 0.001) and mononuclear cell (p = 0.003) infiltration were significantly correlated with gastric-juice ammonia concentration. CONCLUSIONS: Measurement of gastric-juice ammonia concentration by ion-selective electrode or rapid detection device is a relatively insensitive and nonspecific means of H. pylori diagnosis. Gastritis severity increases with gastric-juice ammonia concentration. JF - The American journal of gastroenterology AU - Kearney, D J AU - Ritchie, K AU - Peacock, J S AD - Department of Medicine, Seattle Veterans Administration Medical Center, Washington 98108, USA Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 3399 EP - 3403 VL - 95 IS - 12 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Sensitivity and Specificity KW - Severity of Illness Index KW - Gastroscopy KW - ROC Curve KW - Humans KW - Gastritis -- diagnosis KW - Middle Aged KW - Predictive Value of Tests KW - Gastritis -- microbiology KW - Male KW - Female KW - Ion-Selective Electrodes KW - Helicobacter Infections -- diagnosis KW - Helicobacter pylori KW - Ammonia -- analysis KW - Gastric Juice -- chemistry KW - Helicobacter Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85353398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Gastric-juice+ammonia+assay+for+diagnosis+of+Helicobacter+pylori+infection+and+the+relationship+of+ammonia+concentration+to+gastritis+severity.&rft.au=Kearney%2C+D+J%3BRitchie%2C+K%3BPeacock%2C+J+S&rft.aulast=Kearney&rft.aufirst=D&rft.date=2000-12-01&rft.volume=95&rft.issue=12&rft.spage=3399&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Prasterone (DHEA) and mania. AN - 72516795; 11144700 AB - To inform clinicians and investigators of the potential for severe mania in conjunction with the use of prasterone (DHEA; dehydroepiandrosterone). A 31-year-old Hispanic man was admitted on a 72-hour observation period from a neighboring hospital after threatening to kill himself, family members, and a friend. A loaded rifle was found under his bed. The family confirmed that he had begun using DHEA several weeks prior to his mood and behavioral changes. He denied any past violence, but had once been given an unsubstantiated diagnosis of bipolar disorder. He used alcohol episodically, and had difficulties controlling his anger while intoxicated. Although he improved with valproate, his threats of homicide led to involuntary commitment. Several studies and case reports strongly suggest that anabolic steroids can induce significant psychiatric difficulties, including mania, impaired cognition, and overt psychosis. Although the Food and Drug Administration noted in 1985 that the efficacy and safety of DHEA were never confirmed, the agent continues to be sold over the counter. Several groups have used DHEA in the treatment of AIDS, memory loss, and depression, but reported no serious adverse events; however, recent studies indicate that severe psychiatric symptoms can develop in a subset of users. Although uncertain, potential risk factors include high doses of DHEA; history of mood disorder; concurrent use of alcohol, street drugs, or antidepressants; and cytochrome P450 polymorphisms. The use of DHEA in those under age 35 years may be especially risky, as endogenous DHEA concentrations peak at age 20-30 years. Those using or investigating DHEA should be cognizant of the potential for severe psychiatric complications. JF - The Annals of pharmacotherapy AU - Dean, C E AD - Minneapolis Veteran's Affairs Medical Center, University of Minnesota Department of Psychiatry, 55417, USA. charles.dean@med.va.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1419 EP - 1422 VL - 34 IS - 12 SN - 1060-0280, 1060-0280 KW - Adjuvants, Immunologic KW - 0 KW - Dehydroepiandrosterone KW - 459AG36T1B KW - Index Medicus KW - Humans KW - Adult KW - Adjuvants, Immunologic -- adverse effects KW - Male KW - Dehydroepiandrosterone -- adverse effects KW - Bipolar Disorder -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72516795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Prasterone+%28DHEA%29+and+mania.&rft.au=Dean%2C+C+E&rft.aulast=Dean&rft.aufirst=C&rft.date=2000-12-01&rft.volume=34&rft.issue=12&rft.spage=1419&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-08 N1 - Date created - 2000-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Omeprazole 40 mg once a day is equally effective as lansoprazole 30 mg twice a day in symptom control of patients with gastro-oesophageal reflux disease (GERD) who are resistant to conventional-dose lansoprazole therapy-a prospective, randomized, multi-centre study. AN - 72484821; 11121907 AB - Comparative studies of omeprazole and lansoprazole are scarce and even scarcer are comparisons of higher doses. Most of the comparative studies have assessed the effect of the two proton pump inhibitors (PPIs) on gastric acid secretion or gastric pH. Few studies have compared clinical end-points such as oesophageal healing and symptom control. To determine the clinical efficacy of omeprazole 40 mg daily as compared to lansoprazole 30 mg twice a day in symptom control of patients with severe symptomatic GERD. Ninety-six patients who failed a standard dose of lansoprazole (30 mg once daily), were enrolled in a prospective fashion from three VA medical centres and were randomized to receive 6 weeks of either omeprazole 40 mg daily or lansoprazole 30 mg twice daily. Patients reported daily on symptom severity and frequency, antacid consumption and side-effects. Forty-six patients received omeprazole and 44 lansoprazole. Although not statistically significant, there was a consistent trend of better symptom control in the omeprazole group for daytime and night-time heartburn and acid regurgitation. There was no statistical difference between the two groups in mean antacid consumption overall and at the end of each of the 6 weeks of the study. In addition, there was no significant difference in the overall frequency of side-effects between the two groups nor for each individual side-effect. Omeprazole 40 mg once daily is equally effective and tolerated as lansoprazole 30 mg twice daily in symptom control of patients with GERD. JF - Alimentary pharmacology & therapeutics AU - Fass, R AU - Murthy, U AU - Hayden, C W AU - Malagon, I B AU - Pulliam, G AU - Wendel, C AU - Kovacs, T O AD - Section of Gastroenterology, Department of Medicine, Tucson VA Medical Center, Tucson, Arizona, USA. Ronnie.Fass@Med.VA.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1595 EP - 1603 VL - 14 IS - 12 SN - 0269-2813, 0269-2813 KW - 2-Pyridinylmethylsulfinylbenzimidazoles KW - 0 KW - Enzyme Inhibitors KW - Lansoprazole KW - 0K5C5T2QPG KW - Omeprazole KW - KG60484QX9 KW - Index Medicus KW - Drug Administration Schedule KW - Prospective Studies KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Enzyme Inhibitors -- administration & dosage KW - Omeprazole -- adverse effects KW - Omeprazole -- administration & dosage KW - Omeprazole -- analogs & derivatives KW - Gastroesophageal Reflux -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72484821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alimentary+pharmacology+%26+therapeutics&rft.atitle=Omeprazole+40+mg+once+a+day+is+equally+effective+as+lansoprazole+30+mg+twice+a+day+in+symptom+control+of+patients+with+gastro-oesophageal+reflux+disease+%28GERD%29+who+are+resistant+to+conventional-dose+lansoprazole+therapy-a+prospective%2C+randomized%2C+multi-centre+study.&rft.au=Fass%2C+R%3BMurthy%2C+U%3BHayden%2C+C+W%3BMalagon%2C+I+B%3BPulliam%2C+G%3BWendel%2C+C%3BKovacs%2C+T+O&rft.aulast=Fass&rft.aufirst=R&rft.date=2000-12-01&rft.volume=14&rft.issue=12&rft.spage=1595&rft.isbn=&rft.btitle=&rft.title=Alimentary+pharmacology+%26+therapeutics&rft.issn=02692813&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-18 N1 - Date created - 2001-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reduced inhibition in an animal model of cortical dysplasia. AN - 72451548; 11102503 AB - Cortical dysplasia has a strong association with epilepsy in humans, but the underlying mechanisms for this are poorly understood. In utero irradiation of rats produces diffuse cortical dysplasia and neuronal heterotopia in the neocortex and hippocampus. Using in vitro neocortical slices, whole-cell patch-clamp recordings were obtained from pyramidal neurons in dysplastic cortex and control neocortex. Spontaneous IPSCs were reduced in amplitude (35%) and frequency (70%) in pyramidal cells from dysplastic cortex. Miniature IPSCs were reduced in frequency (66%) in dysplastic cortex. Two additional measures of cortical inhibition, monosynaptic evoked IPSCs and paired pulse depression of evoked EPSCs, were also impaired in dysplastic cortex. Spontaneous EPSCs were increased in amplitude (42%) and frequency (77%) in dysplastic cortex, but miniature EPSCs were not different between the two groups. These data demonstrate significant physiological impairment in inhibitory synaptic transmission in experimental cortical dysplasia. This supports previous immunohistochemical findings in this model and observations in humans of a reduction in the density of inhibitory interneurons in dysplastic cortex. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Zhu, W J AU - Roper, S N AD - Department of Neurological Surgery, University of Florida, and Malcolm Randall Veterans Administration Medical Center, Gainesville, Florida 32610-0265, USA. Y1 - 2000/12/01/ PY - 2000 DA - 2000 Dec 01 SP - 8925 EP - 8931 VL - 20 IS - 23 KW - Excitatory Amino Acid Antagonists KW - 0 KW - GABA-A Receptor Antagonists KW - Tetrodotoxin KW - 4368-28-9 KW - Index Medicus KW - Animals KW - Synaptic Transmission -- radiation effects KW - Gamma Rays KW - Evoked Potentials -- radiation effects KW - Choristoma -- pathology KW - Disease Models, Animal KW - Choristoma -- etiology KW - Electric Stimulation KW - Maternal Exposure KW - Pregnancy KW - Excitatory Amino Acid Antagonists -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Patch-Clamp Techniques KW - Excitatory Postsynaptic Potentials -- drug effects KW - Excitatory Postsynaptic Potentials -- radiation effects KW - In Vitro Techniques KW - Cell Membrane -- metabolism KW - Tetrodotoxin -- pharmacology KW - Female KW - Pyramidal Cells -- physiopathology KW - Neocortex -- metabolism KW - Neocortex -- abnormalities KW - Pyramidal Cells -- radiation effects KW - Neural Inhibition -- radiation effects KW - Pyramidal Cells -- metabolism KW - Neocortex -- physiopathology KW - Neocortex -- pathology KW - Neocortex -- radiation effects KW - Abnormalities, Radiation-Induced -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72451548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Reduced+inhibition+in+an+animal+model+of+cortical+dysplasia.&rft.au=Zhu%2C+W+J%3BRoper%2C+S+N&rft.aulast=Zhu&rft.aufirst=W&rft.date=2000-12-01&rft.volume=20&rft.issue=23&rft.spage=8925&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-08 N1 - Date created - 2001-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vocational rehabilitation outcomes of veterans with substance use disorders in a partial hospitalization program. AN - 72434816; 11097656 AB - The authors examined factors that influenced the employment rates of 529 veterans with severe alcohol and other substance use disorders who were being treated at an addictions partial hospitalization program. The employment rate was significantly higher for veterans who completed the hospitalization program, participated in a Veterans Industries work-for-pay program, and received drug-free supportive housing. JF - Psychiatric services (Washington, D.C.) AU - Kerrigan, A J AU - Kaough, J E AU - Wilson, B L AU - Wilson, J V AU - Boeringa, J A AU - Monga, T N AD - Psychology Service, VA Medical Center, Houston, Texas 77030, USA. kerrigan.anthonyj@med.va.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1570 EP - 1572 VL - 51 IS - 12 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - Hospitalization KW - Humans KW - Adult KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Male KW - Ambulatory Care KW - Veterans -- psychology KW - Rehabilitation, Vocational KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72434816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Vocational+rehabilitation+outcomes+of+veterans+with+substance+use+disorders+in+a+partial+hospitalization+program.&rft.au=Kerrigan%2C+A+J%3BKaough%2C+J+E%3BWilson%2C+B+L%3BWilson%2C+J+V%3BBoeringa%2C+J+A%3BMonga%2C+T+N&rft.aulast=Kerrigan&rft.aufirst=A&rft.date=2000-12-01&rft.volume=51&rft.issue=12&rft.spage=1570&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-26 N1 - Date created - 2001-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relation of family history of suicide to suicide attempts in alcoholics. AN - 72431327; 11097978 AB - This study was an examination of whether a family history of suicide is associated with attempts at suicide among alcoholics. A consecutive series of 333 alcoholics were interviewed about whether or not they had ever attempted suicide and about their family history of suicide. Compared with alcoholics who had never attempted suicide, significantly more of the alcoholics who had attempted suicide reported that a first- or second-degree relative had committed suicide. A family history of suicide may indicate that an alcoholic has a higher risk of attempting suicide. JF - The American journal of psychiatry AU - Roy, A AD - Psychiatry Service, Department of Veteran Affairs, New Jersey Healthcare System, East Orange, 07019, USA. alec.roy@med.va.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 2050 EP - 2051 VL - 157 IS - 12 SN - 0002-953X, 0002-953X KW - Abridged Index Medicus KW - Index Medicus KW - Risk Factors KW - Humans KW - Male KW - Female KW - Suicide, Attempted -- statistics & numerical data KW - Suicide, Attempted -- psychology KW - Alcoholism -- diagnosis KW - Family KW - Suicide -- statistics & numerical data KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72431327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Relation+of+family+history+of+suicide+to+suicide+attempts+in+alcoholics.&rft.au=Roy%2C+A&rft.aulast=Roy&rft.aufirst=A&rft.date=2000-12-01&rft.volume=157&rft.issue=12&rft.spage=2050&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-01 N1 - Date created - 2000-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inflammatory properties of IgG modified by oxygen radicals and peroxynitrite. AN - 72430223; 11086095 AB - In inflammatory arthritis, there is evidence indicating that the affected tissues produce large amounts of oxygen-free radicals and NO. Herein, we examine the biologic effects of exposure of IgG to hypochlorous acid (HOCl) and peroxynitrite (ONOO). The concentrations of IgG modified by chlorination and nitrosation were measured in synovial fluids from inflammatory and noninflammatory arthritis. Human IgG was exposed to increasing concentrations of HOCl and ONOO, and the resulting products were tested for complement component binding; binding to FcgammaRI; activation of polymorphonuclear neutrophils; effect on the Ab-combining site of Abs; and in vivo inflammatory activity in a rabbit model of acute arthritis. Rheumatoid synovial fluids contained significantly greater concentrations of nitrosated and chlorinated IgG compared with ostearthritic specimens. In vitro exposure of human IgG to HOCl and ONOO resulted in a concentration-dependent decrease in C3 and C1q fixation. The decrease in Fc domain-dependent biologic functions was confirmed by competitive binding studies to the FcgammaRI of U937 cells. HOCl-treated IgG monomer was 10 times less effective in competing for binding compared with native IgG, and ONOO-treated IgG was 2.5 times less effective. The modified IgGs were also ineffective in inducing synthesis of H(2)O(2) by human PMN. The Ag-binding domains of IgG also showed a concentration-dependent decrease in binding to Ag. The ability of the modified IgGs to induce acute inflammation in rabbit knees decreased 20-fold as gauged by the intensity of the inflammatory cell exudates. These studies clarify the modulating role of biological oxidants in inflammatory processes in which Ag-autoantibody reactions and immune complex pathogenesis may play an important role. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Uesugi, M AU - Yoshida, K AU - Jasin, H E AD - Division of Rheumatology and Clinical Immunology, Teresa Scheu Rheumatoid Arthritis Research Laboratory, Department of Internal Medicine, University of Arkansas for Medical Sciences, and Veterans Administration Medical Center, Little Rock, AR, USA. Y1 - 2000/12/01/ PY - 2000 DA - 2000 Dec 01 SP - 6532 EP - 6537 VL - 165 IS - 11 SN - 0022-1767, 0022-1767 KW - Complement C3 KW - 0 KW - Free Radicals KW - Immunoglobulin G KW - Nitrates KW - Receptors, IgG KW - Serum Albumin, Bovine KW - peroxynitric acid KW - 26404-66-0 KW - 3-nitrotyrosine KW - 3604-79-3 KW - Tyrosine KW - 42HK56048U KW - Hypochlorous Acid KW - 712K4CDC10 KW - Complement C1q KW - 80295-33-6 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Oxygen KW - S88TT14065 KW - Abridged Index Medicus KW - Index Medicus KW - Gout -- immunology KW - Acute Disease KW - Animals KW - Gout -- metabolism KW - Neutrophils -- immunology KW - Humans KW - Receptors, IgG -- metabolism KW - Synovial Fluid -- immunology KW - Arthritis, Rheumatoid -- metabolism KW - Neutrophils -- metabolism KW - Oxidation-Reduction KW - Hypochlorous Acid -- immunology KW - Osteoarthritis -- metabolism KW - Arthritis, Experimental -- metabolism KW - Serum Albumin, Bovine -- immunology KW - Osteoarthritis -- immunology KW - Serum Albumin, Bovine -- metabolism KW - Synovial Fluid -- metabolism KW - Male KW - Hypochlorous Acid -- metabolism KW - Arthritis, Experimental -- immunology KW - Hydrogen Peroxide -- metabolism KW - Rabbits KW - Complement C1q -- metabolism KW - Complement C3 -- metabolism KW - Binding Sites, Antibody KW - Arthritis, Rheumatoid -- immunology KW - Female KW - Tyrosine -- immunology KW - Oxygen -- metabolism KW - Nitrates -- metabolism KW - Tyrosine -- metabolism KW - Tyrosine -- analogs & derivatives KW - Immunoglobulin G -- toxicity KW - Immunoglobulin G -- metabolism KW - Free Radicals -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72430223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Inflammatory+properties+of+IgG+modified+by+oxygen+radicals+and+peroxynitrite.&rft.au=Uesugi%2C+M%3BYoshida%2C+K%3BJasin%2C+H+E&rft.aulast=Uesugi&rft.aufirst=M&rft.date=2000-12-01&rft.volume=165&rft.issue=11&rft.spage=6532&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2000-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Randomized comparison of linezolid (PNU-100766) versus oxacillin-dicloxacillin for treatment of complicated skin and soft tissue infections. AN - 72419615; 11083648 AB - This randomized, double-blind, multicenter trial compared the efficacy and safety of linezolid, an oxazolidinone, with those of oxacillin-dicloxacillin in patients with complicated skin and soft tissue infections. A total of 826 hospitalized adult patients were randomized to receive linezolid (600 mg intravenously [i.v.]) every 12 h or oxacillin (2 g i.v.) every 6 h; following sufficient clinical improvement, patients were switched to the respective oral agents (linezolid [600 mg orally] every 12 h or dicloxacillin [500 mg orally] every 6 hours). Primary efficacy variables were clinical cure rates in both the intent-to-treat (ITT) population and clinically evaluable (CE) patients and microbiological success rate in microbiologically evaluable (ME) patients. Safety and tolerability were evaluated in the ITT population. Demographics and baseline characteristics were similar across treatment groups in the 819 ITT patients. In the ITT population, the clinical cure rates were 69.8 and 64.9% in the linezolid and oxacillin-dicloxacillin groups, respectively (P = 0.141; 95% confidence interval -1.58 to 11. 25). In 298 CE linezolid-treated patients, the clinical cure rate was 88.6%, compared with a cure rate of 85.8% in 302 CE patients who received oxacillin-dicloxacillin. In 143 ME linezolid-treated patients, the microbiological success rate was 88.1%, compared with a success rate of 86.1% in 151 ME patients who received oxacillin-dicloxacillin. Both agents were well tolerated; most adverse events were of mild-to-moderate intensity. No serious drug-related adverse events were reported in the linezolid group. These data support the use of linezolid for the treatment of adults with complicated skin and soft tissue infections. JF - Antimicrobial agents and chemotherapy AU - Stevens, D L AU - Smith, L G AU - Bruss, J B AU - McConnell-Martin, M A AU - Duvall, S E AU - Todd, W M AU - Hafkin, B AD - Infectious Diseases Section, Veterans Administration Medical Center, Boise, Idaho, USA. dlsteven@primenet.com Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 3408 EP - 3413 VL - 44 IS - 12 SN - 0066-4804, 0066-4804 KW - Acetamides KW - 0 KW - Anti-Infective Agents KW - Oxazolidinones KW - Penicillins KW - Dicloxacillin KW - COF19H7WBK KW - Linezolid KW - ISQ9I6J12J KW - Oxacillin KW - UH95VD7V76 KW - Index Medicus KW - Drug Therapy, Combination KW - Anti-Infective Agents -- therapeutic use KW - Anti-Infective Agents -- adverse effects KW - Double-Blind Method KW - Humans KW - Treatment Outcome KW - Penicillins -- therapeutic use KW - Middle Aged KW - Penicillins -- adverse effects KW - Male KW - Female KW - Soft Tissue Infections -- drug therapy KW - Skin Diseases, Bacterial -- drug therapy KW - Dicloxacillin -- therapeutic use KW - Oxazolidinones -- therapeutic use KW - Oxazolidinones -- adverse effects KW - Oxacillin -- therapeutic use KW - Dicloxacillin -- adverse effects KW - Oxacillin -- adverse effects KW - Acetamides -- therapeutic use KW - Acetamides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72419615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Randomized+comparison+of+linezolid+%28PNU-100766%29+versus+oxacillin-dicloxacillin+for+treatment+of+complicated+skin+and+soft+tissue+infections.&rft.au=Stevens%2C+D+L%3BSmith%2C+L+G%3BBruss%2C+J+B%3BMcConnell-Martin%2C+M+A%3BDuvall%2C+S+E%3BTodd%2C+W+M%3BHafkin%2C+B&rft.aulast=Stevens&rft.aufirst=D&rft.date=2000-12-01&rft.volume=44&rft.issue=12&rft.spage=3408&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-15 N1 - Date created - 2000-11-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Infect Dis. 1999 Oct;29(4):760-7 [10589883] Antimicrob Agents Chemother. 1997 Nov;41(11):2573-5 [9371372] Antimicrob Agents Chemother. 1987 Feb;31(2):213-8 [2882731] Antimicrob Agents Chemother. 1988 Sep;32(9):1341-6 [3058018] Med Res Rev. 1989 Jan-Mar;9(1):45-89 [2644497] Lancet. 1997 Dec 6;350(9092):1670-3 [9400512] World J Surg. 1998 Feb;22(2):146-51 [9451929] Antimicrob Agents Chemother. 1998 Mar;42(3):721-4 [9517963] Pharmacotherapy. 1998 May-Jun;18(3):456-62 [9620097] Lancet. 1998 Apr 18;351(9110):1212 [9643727] Am J Med. 1998 May 29;104(5A):7S-10S [9684652] Arch Dermatol. 1998 Aug;134(8):1006-9 [9722732] Antimicrob Agents Chemother. 1998 Dec;42(12):3251-5 [9835522] Antimicrob Agents Chemother. 1999 Aug;43(8):2059-62 [10428937] Eur J Clin Microbiol Infect Dis. 1999 Jun;18(6):403-8 [10442417] J Antimicrob Chemother. 1999 Sep;44 Suppl A:19-23 [10511393] Infect Control Hosp Epidemiol. 1992 Oct;13(10):582-6 [1469266] Eur J Clin Microbiol Infect Dis. 1994 Jan;13(1):50-5 [8168564] Clin Infect Dis. 1995 Jun;20 Suppl 2:S154-7 [7548539] N Engl J Med. 1996 Jan 25;334(4):240-5 [8532002] Antimicrob Agents Chemother. 1996 Apr;40(4):839-45 [8849237] Antimicrob Agents Chemother. 1996 Jun;40(6):1508-13 [8726028] Antimicrob Agents Chemother. 1996 Jul;40(7):1745-7 [8807077] Antimicrob Agents Chemother. 1997 Feb;41(2):465-7 [9021209] MMWR Morb Mortal Wkly Rep. 1997 Aug 22;46(33):765-6 [9272582] MMWR Morb Mortal Wkly Rep. 1997 Sep 5;46(35):813-5 [9310213] Clin Infect Dis. 2001 Feb 1;32(3):402-12 [11170948] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epinephrine correction of impaired platelet thromboxane receptor signaling. AN - 72418995; 11078690 AB - This study evaluated the mechanism of epinephrine potentiation of platelet secretion induced by thromboxane A(2) (TXA(2)). Dog platelets that do not secrete in response to TXA(2) alone (TXA(2)-) were compared with dog platelets that do secrete (TXA(2)+) and with human platelets. TXA(2)- platelets had impaired TXA(2) receptor (TP receptor)-G protein coupling, indicated by 1) impaired stimulated GTPase activity, 2) elevated basal guanosine 5'-O-(3-thiotriphosphate) binding, and 3) elevated Galpha(q) palmitate turnover that was corrected by preexposure to epinephrine. Kinetic agonist binding studies revealed biphasic dog and human platelet TP receptor association and dissociation. TXA(2)- and TP receptor-desensitized TXA(2)+ dog and human platelets had altered ligand binding parameters compared with untreated TXA(2)+ or human platelets. These parameters were reversed, along with impaired secretion, by epinephrine. Basal phosphorylation of TXA(2)- platelet TP receptors was elevated 60% and was normalized by epinephrine. Epinephrine potentiates platelet secretion stimulated by TXA(2) by reducing basal TP receptor phosphorylation and facilitating TP receptor-G protein coupling in TXA(2)- platelets and, probably, in normal platelets as well. JF - American journal of physiology. Cell physiology AU - Dunlop, P C AU - Leis, L A AU - Johnson, G J AD - Hematology/Oncology Section, Department of Medicine, Veterans Administration Medical Center and University of Minnesota, Minneapolis, Minnesota 55417, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - C1760 EP - C1771 VL - 279 IS - 6 SN - 0363-6143, 0363-6143 KW - Carbon Radioisotopes KW - 0 KW - Iodine Radioisotopes KW - Mutagens KW - Nitrosamines KW - Palmitates KW - Receptors, Thromboxane KW - Sulfur Radioisotopes KW - Vasoconstrictor Agents KW - Tritium KW - 10028-17-8 KW - Guanosine 5'-O-(3-Thiotriphosphate) KW - 37589-80-3 KW - Thromboxane A2 KW - 57576-52-0 KW - nitrosobis(2-oxopropyl)amine KW - 60599-38-4 KW - 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid KW - 76898-47-0 KW - Inositol 1,4,5-Trisphosphate KW - 85166-31-0 KW - GTP Phosphohydrolases KW - EC 3.6.1.- KW - GTP-Binding Proteins KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid -- pharmacology KW - Animals KW - Humans KW - Nitrosamines -- metabolism KW - Inositol 1,4,5-Trisphosphate -- biosynthesis KW - Amino Acid Sequence KW - Mutagens -- pharmacology KW - Guanosine 5'-O-(3-Thiotriphosphate) -- pharmacology KW - Palmitates -- pharmacology KW - Nitrosamines -- pharmacology KW - Thromboxane A2 -- metabolism KW - Phosphorylation KW - Mutagens -- metabolism KW - Kinetics KW - GTP Phosphohydrolases -- metabolism KW - GTP-Binding Proteins -- metabolism KW - Blood Platelets -- enzymology KW - Molecular Sequence Data KW - Dogs KW - Guanosine 5'-O-(3-Thiotriphosphate) -- metabolism KW - Palmitates -- metabolism KW - Platelet Activation -- physiology KW - Signal Transduction -- physiology KW - Vasoconstrictor Agents -- pharmacology KW - Receptors, Thromboxane -- metabolism KW - Epinephrine -- pharmacology KW - Signal Transduction -- drug effects KW - Receptors, Thromboxane -- chemistry KW - Platelet Activation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72418995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Cell+physiology&rft.atitle=Epinephrine+correction+of+impaired+platelet+thromboxane+receptor+signaling.&rft.au=Dunlop%2C+P+C%3BLeis%2C+L+A%3BJohnson%2C+G+J&rft.aulast=Dunlop&rft.aufirst=P&rft.date=2000-12-01&rft.volume=279&rft.issue=6&rft.spage=C1760&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Cell+physiology&rft.issn=03636143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of cholera toxin and cyclic adenosine monophosphate on fluid-phase endocytosis, distribution, and trafficking of endosomes in rat liver. AN - 70774696; 11093743 AB - In prior studies, we showed that cholera (CTX) and pertussis toxins (PTX) increase rat liver endosome acidification. This study was performed to characterize the effects of these toxins and cyclic adenosine monophosphate (cAMP) on endosome ion transport, fluid-phase endocytosis (FPE), and endosome trafficking in liver. In control liver, more mature populations of endosomes acidified progressively more slowly, but both toxins and cAMP caused retention of an early endosome acidification profile in maturing endosomes. CTX caused a density shift in endosomes, and all agents increased net FPE at time points from 5 to 60 minutes. By confocal microscopy, fluorescent dextrans first appeared in small vesicles at the hepatocyte sinusoidal membrane and trafficked rapidly to the pericanalicular area, near lysosomes and the trans-Golgi network (TGN). Prolonged exposure to these agents caused redistribution of many labeled vesicles to the perinuclear region, colocalized with markers of both early (EEA1 and transferrin receptor) and late (LAMP1) endosomes. We conclude that cAMP is the common agent that disrupted normal maturation and trafficking of endosomes and increased net FPE, in part via decreased diacytosis. JF - Hepatology (Baltimore, Md.) AU - Van Dyke, R W AD - Department of Medicine, University of Michigan Medical School and Veterans' Administration Hospital, Ann Arbor, MI 48109-0682, USA. wynne@umich.edu Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1357 EP - 1369 VL - 32 IS - 6 SN - 0270-9139, 0270-9139 KW - Acids KW - 0 KW - Biomarkers KW - Virulence Factors, Bordetella KW - Bucladesine KW - 63X7MBT2LQ KW - Cholera Toxin KW - 9012-63-9 KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Rats KW - Virulence Factors, Bordetella -- pharmacology KW - Animals KW - Rats, Sprague-Dawley KW - Acids -- metabolism KW - Lysosomes -- metabolism KW - Tissue Distribution -- drug effects KW - Bucladesine -- pharmacology KW - Time Factors KW - Male KW - Acids -- pharmacology KW - Liver -- ultrastructure KW - Endosomes -- physiology KW - Liver -- drug effects KW - Cyclic AMP -- pharmacology KW - Endocytosis -- drug effects KW - Cholera Toxin -- pharmacology KW - Liver -- metabolism KW - Liver -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70774696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Effect+of+cholera+toxin+and+cyclic+adenosine+monophosphate+on+fluid-phase+endocytosis%2C+distribution%2C+and+trafficking+of+endosomes+in+rat+liver.&rft.au=Van+Dyke%2C+R+W&rft.aulast=Van+Dyke&rft.aufirst=R&rft.date=2000-12-01&rft.volume=32&rft.issue=6&rft.spage=1357&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Functional expression of NAD(P)H oxidase p47 in lung microvascular endothelial cells. AN - 72436655; 11095953 AB - Vascular endothelial cell superoxide (O(*)(2)) has an important role in intracellular signaling, in interaction with other reactive species such as nitric oxide, and in vascular dysfunction. Little is known regarding the source and function of O(*)(2) from microvascular endothelial cells from specific tissues. Mouse lung microvascular endothelial cells stimulated with phorbol ester (PMA) or NADPH generated significant O(*)(2), which was inhibited by diphenyleneiodonium (DPI) but not by allopurinol, rotenone, indomethacin, or quinacrine. Optimal O(*)(2) generation required cytosolic as well as particulate cell fractions of cells. In parallel studies, PMA induced increased expression of the p47 component of the NAD(P)H oxidase in the particulate fraction, which was inhibited by staurosporine and calphostin. These data demonstrate that NAD(P)H oxidase is an important source of O(*)(2) generation in lung microvascular endothelial cells. Copyright 2000 Academic Press. JF - Biochemical and biophysical research communications AU - Murphy, H S AU - Yu, C AU - Quddus, J AD - Pathology and Laboratory Medicine, Veterans Administration Medical Center, Ann Arbor, Michigan, 48109, USA. hsmurphy@umich.edu Y1 - 2000/11/30/ PY - 2000 DA - 2000 Nov 30 SP - 584 EP - 589 VL - 278 IS - 3 SN - 0006-291X, 0006-291X KW - Enzyme Inhibitors KW - 0 KW - Onium Compounds KW - Phosphoproteins KW - Rotenone KW - 03L9OT429T KW - Superoxides KW - 11062-77-4 KW - Allopurinol KW - 63CZ7GJN5I KW - diphenyleneiodonium KW - 6HJ411TU98 KW - NADH, NADPH Oxidoreductases KW - EC 1.6.- KW - NADPH Oxidase KW - EC 1.6.3.1 KW - neutrophil cytosolic factor 1 KW - Quinacrine KW - H0C805XYDE KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Onium Compounds -- pharmacology KW - Animals KW - HL-60 Cells KW - Animal Population Groups KW - Humans KW - Mice KW - Rotenone -- pharmacology KW - Quinacrine -- pharmacology KW - Indomethacin -- pharmacology KW - Allopurinol -- pharmacology KW - Superoxides -- metabolism KW - Cells, Cultured KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Microcirculation KW - Signal Transduction KW - Mice, Inbred AKR KW - Endothelium, Vascular -- enzymology KW - Endothelium, Vascular -- drug effects KW - Endothelium, Vascular -- cytology KW - NADH, NADPH Oxidoreductases -- metabolism KW - Pulmonary Circulation KW - Phosphoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72436655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Functional+expression+of+NAD%28P%29H+oxidase+p47+in+lung+microvascular+endothelial+cells.&rft.au=Murphy%2C+H+S%3BYu%2C+C%3BQuddus%2C+J&rft.aulast=Murphy&rft.aufirst=H&rft.date=2000-11-30&rft.volume=278&rft.issue=3&rft.spage=584&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. AN - 72432731; 11087869 AB - There is evidence from both genetic and pharmacologic studies to suggest that the cyclooxygenase-2 (COX-2) enzyme plays a causal role in the development of colorectal cancer. However, little is known about the identity or role of the eicosanoid receptor pathways activated by COX-derived prostaglandins (PG). We previously have reported that COX-2-derived prostacyclin promotes embryo implantation in the mouse uterus via activation of the nuclear hormone receptor peroxisome proliferator-activated receptor (PPAR) delta. In light of the recent finding that PPARdelta is a target of beta-catenin transactivation, it is important to determine whether this signaling pathway is operative during the development of colorectal cancer. Analysis of PPARdelta mRNA in matched normal and tumor samples revealed that expression of PPARdelta, similar to COX-2, is up-regulated in colorectal carcinomas. In situ hybridization studies demonstrate that PPARdelta is expressed in normal colon and localized to the epithelial cells at the very tips of the mucosal glands. In contrast, expression of PPARdelta mRNA in colorectal tumors was more widespread with increased levels in transformed epithelial cells. Analysis of PPARdelta and COX-2 mRNA in serial sections suggested they were colocalized to the same region within a tumor. Finally, transient transfection assays established that endogenously synthesized prostacyclin (PGI(2)) could serve as a ligand for PPARdelta. In addition, the stable PGI(2) analog, carbaprostacyclin, and a synthetic PPARdelta agonist induced transactivation of endogenous PPARdelta in human colon carcinoma cells. We conclude from these observations that PPARdelta, similar to COX-2, is aberrantly expressed in colorectal tumors and that endogenous PPARdelta is transcriptionally responsive to PGI(2). However, the functional consequence of PPARdelta activation in colon carcinogenesis still needs to be determined. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Gupta, R A AU - Tan, J AU - Krause, W F AU - Geraci, M W AU - Willson, T M AU - Dey, S K AU - DuBois, R N AD - Departments of Medicine and Cell Biology, Vanderbilt University Medical Center and Veterans Administration Medical Center, Nashville, TN 37232, USA. Y1 - 2000/11/21/ PY - 2000 DA - 2000 Nov 21 SP - 13275 EP - 13280 VL - 97 IS - 24 SN - 0027-8424, 0027-8424 KW - Isoenzymes KW - 0 KW - Membrane Proteins KW - Nuclear Proteins KW - Receptors, Cytoplasmic and Nuclear KW - Recombinant Fusion Proteins KW - Transcription Factors KW - carboprostacyclin KW - 69552-46-1 KW - Epoprostenol KW - DCR9Z582X0 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Index Medicus KW - Animals KW - Nuclear Proteins -- genetics KW - Rectal Neoplasms KW - Humans KW - Intestinal Mucosa -- enzymology KW - Intestinal Mucosa -- metabolism KW - Transcription, Genetic KW - Mice KW - Isoenzymes -- genetics KW - Recombinant Fusion Proteins -- metabolism KW - In Situ Hybridization KW - Tumor Cells, Cultured KW - Colon KW - Transfection KW - Prostaglandin-Endoperoxide Synthases -- genetics KW - Up-Regulation KW - Adenocarcinoma KW - Nuclear Proteins -- physiology KW - Colonic Neoplasms KW - Signal Transduction KW - Receptors, Cytoplasmic and Nuclear -- physiology KW - Transcription Factors -- physiology KW - Epoprostenol -- pharmacology KW - Colorectal Neoplasms -- pathology KW - Gene Expression Regulation, Neoplastic -- physiology KW - Epoprostenol -- physiology KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Colorectal Neoplasms -- genetics KW - Colorectal Neoplasms -- enzymology KW - Transcription Factors -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Epoprostenol -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72432731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Prostacyclin-mediated+activation+of+peroxisome+proliferator-activated+receptor+delta+in+colorectal+cancer.&rft.au=Gupta%2C+R+A%3BTan%2C+J%3BKrause%2C+W+F%3BGeraci%2C+M+W%3BWillson%2C+T+M%3BDey%2C+S+K%3BDuBois%2C+R+N&rft.aulast=Gupta&rft.aufirst=R&rft.date=2000-11-21&rft.volume=97&rft.issue=24&rft.spage=13275&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-24 N1 - Date created - 2000-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gastroenterology. 1996 Apr;110(4):1259-62 [8613017] J Cell Biochem. 1996 Jun 15;61(4):514-23 [8806074] Genes Dev. 1999 Jun 15;13(12):1561-74 [10385625] Mol Cell. 1999 Jun;3(6):799-804 [10394368] Nature. 1999 Jul 22;400(6742):378-82 [10432118] Cell. 1996 Oct 18;87(2):159-70 [8861899] Cell. 1996 Nov 29;87(5):803-9 [8945508] Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):237-41 [8990192] Ann N Y Acad Sci. 1996 Dec 27;804:176-201 [8993544] Science. 1997 Mar 21;275(5307):1784-7 [9065401] Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3336-40 [9096394] Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4312-7 [9113986] J Clin Invest. 1997 May 1;99(9):2254-9 [9151799] Cell. 1997 Oct 17;91(2):197-208 [9346237] Carcinogenesis. 1997 Nov;18(11):2029-33 [9395198] Nature. 1998 Jan 1;391(6662):79-82 [9422508] Nature. 1998 Jan 1;391(6662):82-6 [9422509] Chem Biol. 1997 Dec;4(12):909-18 [9427656] Diabetes. 1998 Apr;47(4):507-14 [9568680] Cell. 1998 Apr 17;93(2):241-52 [9568716] Gastroenterology. 1998 May;114(5):1095-8 [9606094] Cell. 1998 May 29;93(5):705-16 [9630216] Mol Cell. 1998 Feb;1(3):465-70 [9660931] Nat Med. 1998 Sep;4(9):1046-52 [9734398] FASEB J. 1998 Sep;12(12):1063-73 [9737710] Gastroenterology. 1998 Nov;115(5):1049-55 [9797355] Carcinogenesis. 1998 Dec;19(12):2195-9 [9886578] Carcinogenesis. 1999 Feb;20(2):185-91 [10069452] Nature. 1999 Apr 1;398(6726):422-6 [10201372] J Clin Invest. 1999 Jun;103(11):1509-15 [10359560] Oncogene. 1999 May 6;18(18):2883-91 [10362259] Carcinogenesis. 1999 Nov;20(11):2045-9 [10545404] Recent Prog Horm Res. 1999;54:345-67; discussion 367-8 [10548883] Cell. 1999 Oct 29;99(3):335-45 [10555149] Br J Cancer. 1999 Dec;81(8):1274-9 [10604722] Oncogene. 1999 Dec 20;18(55):7908-16 [10630643] Am J Pathol. 2000 Feb;156(2):545-53 [10666384] J Med Chem. 2000 Feb 24;43(4):527-50 [10691680] N Engl J Med. 2000 Jun 29;342(26):1946-52 [10874062] Cancer Res. 1985 Aug;45(8):3790-5 [4016751] Nature. 1992 Sep 17;359(6392):235-7 [1528264] J Clin Invest. 1994 Feb;93(2):493-8 [8113389] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7355-9 [8041794] Gastroenterology. 1994 Oct;107(4):1183-8 [7926468] Cell. 1994 Dec 30;79(7):1147-56 [8001151] Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):3046-50 [7708772] Cancer Res. 1995 Jun 15;55(12):2556-9 [7780968] Cancer Res. 1995 Sep 1;55(17):3785-9 [7641194] Cell. 1995 Nov 3;83(3):493-501 [8521479] Cell. 1995 Dec 1;83(5):803-12 [8521497] Cell. 1995 Dec 1;83(5):813-9 [8521498] N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Genetic control of the immunologic response to pneumococcal capsular polysaccharides AN - 17735748; 4804583 AB - This brief review will address the limited body of information available on the gentic control of immunologic responses to capsular polysaccharides of Streptococcus pneumoniae (CPS). We hope to show that, although relatively little has been written on this subject, it appears to provide a fertile area for basic, as well as for clinical investigation. Our initial interest in the genetics of human response to CPS grew out of the observation that some perfectly healthy persons fail to make IgG antibody to many or most CPS with which they are vaccinated. This observation, in turn, required the availability of a specific assay to measure such antibody; as a result, we will begin by reviewing briefly the development of such an assay. JF - Vaccine AU - Musher, D M AU - Watson, DA AU - Baughn, R E Y1 - 2000/11/08/ PY - 2000 DA - 2000 Nov 08 SP - 623 EP - 627 PB - Butterworth-Heinemann, 313 Washington St. Newton MA 02158 USA VL - 19 IS - 6 KW - immunology KW - gentic control KW - Streptococcus pneumoniae KW - polysaccharides KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Capsules KW - Reviews KW - Immunoglobulin G KW - Immune response KW - Polysaccharides KW - Pneumonia KW - F 06807:Active immunization KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17735748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Genetic+control+of+the+immunologic+response+to+pneumococcal+capsular+polysaccharides&rft.au=Musher%2C+D+M%3BWatson%2C+DA%3BBaughn%2C+R+E&rft.aulast=Musher&rft.aufirst=D&rft.date=2000-11-08&rft.volume=19&rft.issue=6&rft.spage=623&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Gender differences in the development of substance-related problems: the impact of family history of alcoholism, family history of violence and childhood conduct problems. AN - 72527828; 11188490 AB - This study examined gender differences regarding the relative influence of family history of alcoholism (FHA) and family history of violence (FHV) on reported childhood conduct problems (CCP) and adult problems with alcohol, drugs and violence. The participants were 110 men and 103 women with alcohol-related problems recruited within 30 days of enrolling in treatment for substance abuse or dependence. Participants completed self-report measures of pretreatment violence, FHV, CCP, substance use and consequences, and demographics; a semi-structured interview was used to assess FHA. Structural equation modeling (SEM) analyses revealed gender differences with regard to the influence of FHA and FHV as important factors in the development of childhood and adult behavioral problems. For women, the influence of FHA on subsequent childhood conduct problems and adult problems with alcohol was accounted for by FHV. For men, FHA was not directly associated with CCP or adult problems with alcohol and violence, but was associated with adult drug problems. For both men and women, FHV was associated with CCP, and CCP were associated with adult problems with drugs and violence. Overall, the analyses illustrate the relative importance of FHV as a risk factor in the developmental course leading to problems with drugs and violence among individuals with alcohol-related problems enrolled in treatment for substance abuse or dependence. Further, there was evidence that women may be impacted more than men by family background variables (both FHA and FHV) in terms of the development of adult problems with alcohol, drugs and violence. JF - Journal of studies on alcohol AU - Chermack, S T AU - Stoltenberg, S F AU - Fuller, B E AU - Blow, F C AD - Psychiatry Service, John D. Dingell Veterans Affairs Medical Center, Detroit, Michigan 48201, USA. Stephen.Chermack@med.va.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 845 EP - 852 VL - 61 IS - 6 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Personality Assessment KW - Adolescent KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Child of Impaired Parents -- psychology KW - Child Behavior Disorders -- psychology KW - Gender Identity KW - Personality Development KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Violence -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72527828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Gender+differences+in+the+development+of+substance-related+problems%3A+the+impact+of+family+history+of+alcoholism%2C+family+history+of+violence+and+childhood+conduct+problems.&rft.au=Chermack%2C+S+T%3BStoltenberg%2C+S+F%3BFuller%2C+B+E%3BBlow%2C+F+C&rft.aulast=Chermack&rft.aufirst=S&rft.date=2000-11-01&rft.volume=61&rft.issue=6&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-15 N1 - Date created - 2001-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Elderly Medicare inpatients with substance use disorders: characteristics and predictors of hospital readmissions over a four-year interval. AN - 72527072; 11188495 AB - (1) To describe the characteristics and 4-year readmissions of elderly Medicare inpatients with substance use disorders; (2) to determine whether their readmissions are elevated relative to case controls'; and (3) to examine gender differences in characteristics and predictors of readmissions among elderly inpatients with substance use disorders. Health Care Financing Administration Medicare Provider Analysis and Review data were used to identify elderly patients with substance use disorders and their case controls, and to determine patient characteristics and readmissions over a 4-year interval following hospital discharge. Of elderly inpatients with substance use disorders (N = 22,768), 37% were women, 11% were black, 22% had previous, substance-related hospitalizations, 14% had concomitant psychiatric disorders and 9% had accident-related diagnoses. Among surviving patients with substance use disorders (N = 12,417), 73% were rehospitalized, a higher rate than among case controls (69%). Women with substance use disorders were more likely to have a psychiatric or accident diagnosis at the index episode than were men with substance use disorders. Many women and a disproportionate number of blacks constitute elderly Medicare inpatients with substance use disorders. These patients often have prior substance-related hospitalizations, psychiatric comorbidities, and accidents involving poisoning, adverse drug reactions and falls. They make costly, relatively heavy use of inpatient health services. Elderly women with substance use disorders may benefit from treatment that focuses on their psychiatric disorders and accident risk. Diagnostic information available at discharge can be used to identify patients at higher risk for subsequent rehospitalization and to plan treatment accordingly. JF - Journal of studies on alcohol AU - Brennan, P L AU - Kagay, C R AU - Geppert, J J AU - Moos, R H AD - Center for Health Care Evaluation, VA Palo Alto Health Care System, California 94304, USA. penny.brennan@med.va.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 891 EP - 895 VL - 61 IS - 6 SN - 0096-882X, 0096-882X KW - Index Medicus KW - United States KW - California KW - Mental Disorders -- rehabilitation KW - Risk Factors KW - Mental Disorders -- epidemiology KW - Humans KW - Prognosis KW - Case-Control Studies KW - Aged KW - Male KW - Female KW - Comorbidity KW - Patient Readmission -- statistics & numerical data KW - Alcoholism -- rehabilitation KW - Alcoholism -- epidemiology KW - Medicare KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72527072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Elderly+Medicare+inpatients+with+substance+use+disorders%3A+characteristics+and+predictors+of+hospital+readmissions+over+a+four-year+interval.&rft.au=Brennan%2C+P+L%3BKagay%2C+C+R%3BGeppert%2C+J+J%3BMoos%2C+R+H&rft.aulast=Brennan&rft.aufirst=P&rft.date=2000-11-01&rft.volume=61&rft.issue=6&rft.spage=891&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-15 N1 - Date created - 2001-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Time course inhibition of gastric and platelet COX activity by acetylsalicylic acid in humans. AN - 72374257; 11053009 AB - Aspirin causes peptic ulcers predominately by reducing gastric mucosal cyclooxygenase (COX) activity and prostaglandin synthesis. Because aspirin circulates for only a few hours, we hypothesized that aspirin's inhibitory effect on gastric COX activity must be prolonged. We performed a placebo-controlled experiment in healthy humans to determine the duration of inhibition of aspirin on gastric mucosal COX activity (PGE(2) and PGF(2alpha) synthesis rates). Recovery of gastric COX activity after stopping aspirin was slow and linear. Seventy-two hours after 325-mg aspirin, gastric COX activity was still reduced by 57% (P < 0.001). Duration of inhibition of gastric COX activity was estimated to be 7-8 days after 325-mg aspirin and 5 days after 81-mg aspirin. Recovery of gastric prostaglandin synthesis after 325-mg but not after 81-mg aspirin occurred at slower rates in subjects with Helicobacter pylori-associated gastritis than in those with normal histology. In conclusion, aspirin inhibits gastric COX activity for much longer than predicted from its pharmacokinetic profile, explaining why aspirin at widely spaced intervals is ulcerogenic. JF - American journal of physiology. Gastrointestinal and liver physiology AU - Feldman, M AU - Shewmake, K AU - Cryer, B AD - Medical Service, Dallas Department of Veterans Affairs Medical Center, and Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas 75216, USA. mark.feldman@med.va.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - G1113 EP - G1120 VL - 279 IS - 5 SN - 0193-1857, 0193-1857 KW - Cyclooxygenase Inhibitors KW - 0 KW - Thromboxane A2 KW - 57576-52-0 KW - Dinoprost KW - B7IN85G1HY KW - Prostaglandin-Endoperoxide Synthases KW - EC 1.14.99.1 KW - Dinoprostone KW - K7Q1JQR04M KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Regression Analysis KW - Helicobacter pylori KW - Dinoprost -- biosynthesis KW - Stomach Ulcer -- microbiology KW - Dinoprostone -- biosynthesis KW - Humans KW - Stomach Ulcer -- metabolism KW - Stomach Ulcer -- chemically induced KW - Adult KW - Gastritis -- metabolism KW - Middle Aged KW - Adolescent KW - Time Factors KW - Thromboxane A2 -- blood KW - Gastritis -- microbiology KW - Female KW - Helicobacter Infections -- metabolism KW - Male KW - Cyclooxygenase Inhibitors -- adverse effects KW - Gastric Mucosa -- microbiology KW - Gastric Mucosa -- enzymology KW - Aspirin -- adverse effects KW - Aspirin -- administration & dosage KW - Prostaglandin-Endoperoxide Synthases -- metabolism KW - Cyclooxygenase Inhibitors -- administration & dosage KW - Blood Platelets -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72374257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Gastrointestinal+and+liver+physiology&rft.atitle=Time+course+inhibition+of+gastric+and+platelet+COX+activity+by+acetylsalicylic+acid+in+humans.&rft.au=Feldman%2C+M%3BShewmake%2C+K%3BCryer%2C+B&rft.aulast=Feldman&rft.aufirst=M&rft.date=2000-11-01&rft.volume=279&rft.issue=5&rft.spage=G1113&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Gastrointestinal+and+liver+physiology&rft.issn=01931857&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transcriptional regulation of the human interleukin 1beta gene by fibronectin: role of protein kinase C and activator protein 1 (AP-1). AN - 72362892; 11052809 AB - Interleukin 1beta (IL-1beta) is a multifunctional polypeptide considered a key cytokine during inflammation. Fibronectin (FN), a matrix glycoprotein highly expressed in injured tissues, can induce expression of IL-1beta in human blood monocytic cells. Herein, we explore the intracellular signals and transcriptional mechanisms responsible for IL-1beta induction by FN using human promonocytic U937 cells transfected with the human IL-1beta promoter connected to a reporter gene. Exposure of transfected U937s to FN resulted in increased expression of the full-length IL-1beta promoter. This effect, mediated via the alpha5beta1 integrin, was associated with activation of mitogen-activated protein kinases (MAPKs) and was abolished by pre-treatment of cells with Calphostin C, a specific inhibitor of protein kinase C (PKC) activation. Deletion analysis and co-transfection studies using consensus activator protein 1 (AP-1) oligonucleotides suggested that an AP-1 site present in the 5' end of the IL-1beta promoter was involved in the FN-induced response. Finally, electrophoretic mobility shift assays showed that FN induced binding of AP-1, but not NF-kappaB. Together, these experiments demonstrate that FN binding to the alpha5beta1 integrin activates MAPK-dependent signal pathways, and results in the transcription of the IL-1beta promoter in U937 cells by activating PKC and inducing AP-1. Copyright 2000 Academic Press. JF - Cytokine AU - Roman, J AU - Ritzenthaler, J D AU - Fenton, M J AU - Roser, S AU - Schuyler, W AD - Pulmonary and Critical Care Division, Department of Medicine, Atlanta Veterans Affairs Medical Center and Emory University School of Medicine, Atlanta, Georgia, USA. roman-rodriguez.jesse@atlanta.va.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 1581 EP - 1596 VL - 12 IS - 11 SN - 1043-4666, 1043-4666 KW - Enzyme Inhibitors KW - 0 KW - Fibronectins KW - Interleukin-1 KW - Lipopolysaccharides KW - NF-kappa B KW - Naphthalenes KW - Oligopeptides KW - RNA, Messenger KW - Receptors, Fibronectin KW - Transcription Factor AP-1 KW - arginyl-glycyl-aspartic acid KW - 78VO7F77PN KW - Chloramphenicol O-Acetyltransferase KW - EC 2.3.1.28 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Mitogen-Activated Protein Kinase 1 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 3 KW - Mitogen-Activated Protein Kinases KW - calphostin C KW - I271P23G24 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Naphthalenes -- pharmacology KW - Blotting, Northern KW - Electroporation KW - Lipopolysaccharides -- pharmacology KW - Humans KW - Receptors, Fibronectin -- metabolism KW - Promoter Regions, Genetic KW - Genes, Reporter KW - Signal Transduction KW - Enzyme Activation KW - Dose-Response Relationship, Drug KW - Mitogen-Activated Protein Kinases -- metabolism KW - Chloramphenicol O-Acetyltransferase -- metabolism KW - Precipitin Tests KW - Reverse Transcriptase Polymerase Chain Reaction KW - Gene Deletion KW - Blotting, Western KW - MAP Kinase Signaling System KW - RNA, Messenger -- metabolism KW - Transfection KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Oligopeptides -- pharmacology KW - U937 Cells KW - Cell Adhesion KW - NF-kappa B -- metabolism KW - Protein Kinase C -- antagonists & inhibitors KW - Interleukin-1 -- metabolism KW - Fibronectins -- metabolism KW - Transcription, Genetic KW - Interleukin-1 -- genetics KW - Gene Expression Regulation KW - Protein Kinase C -- physiology KW - Transcription Factor AP-1 -- physiology KW - Fibronectins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72362892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine&rft.atitle=Transcriptional+regulation+of+the+human+interleukin+1beta+gene+by+fibronectin%3A+role+of+protein+kinase+C+and+activator+protein+1+%28AP-1%29.&rft.au=Roman%2C+J%3BRitzenthaler%2C+J+D%3BFenton%2C+M+J%3BRoser%2C+S%3BSchuyler%2C+W&rft.aulast=Roman&rft.aufirst=J&rft.date=2000-11-01&rft.volume=12&rft.issue=11&rft.spage=1581&rft.isbn=&rft.btitle=&rft.title=Cytokine&rft.issn=10434666&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2000-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of arsenite on the induction of CYP1A4 and CYP1A5 in cultured chick embryo hepatocytes. AN - 72355552; 11042089 AB - We had reported previously that 2.5-5 microM sodium arsenite decreased the phenobarbital-mediated induction of CYP2H activity and protein but not CYP2H1 mRNA in chick-embryo hepatocyte cultures. Induction of a CYP1A activity and protein by 3-methylcholanthrene was also decreased by low arsenite concentrations; however, CYP1A mRNAs were not measured in those studies. We report here that low concentrations of arsenite decreased induction of activities and mRNAs of two chicken cytochromes P450, CYP1A (1A4 and 1A5), by 3-methylcholanthrene in chick-embryo hepatocyte cultures. Arsenite treatment did not affect the turnover of either mRNA, nor did it decrease the superinduction of each mRNA caused by treatment with cycloheximide in addition to 3-methylcholanthrene. Glutathione depletion enhanced the effect of arsenite to decrease induction of CYP1A4. These results indicate the induction of CYP1A4 and 1A5 is inhibited by sodium arsenite at the level of transcription, suggesting that the Ah receptor complex may be involved. Copyright 2000 Academic Press. JF - Toxicology and applied pharmacology AU - Jacobs, J M AU - Nichols, C AU - Marek, D AU - Gorman, N AU - Walton, H S AU - Sinclair, P R AU - Sinclair, J F AD - Veterans Administration Medical Center, White River Junction, VT 05009-0001, USA. Y1 - 2000/11/01/ PY - 2000 DA - 2000 Nov 01 SP - 177 EP - 182 VL - 168 IS - 3 SN - 0041-008X, 0041-008X KW - Arsenites KW - 0 KW - Avian Proteins KW - Indicators and Reagents KW - Protein Synthesis Inhibitors KW - RNA, Messenger KW - Uroporphyrinogens KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Cycloheximide KW - 98600C0908 KW - Oxidoreductases KW - EC 1.- KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1A4 protein, Gallus gallus KW - cytochrome P-450 CYP1A5 KW - Glutathione KW - GAN16C9B8O KW - arsenite KW - N5509X556J KW - Index Medicus KW - Oxidation-Reduction KW - Animals KW - Protein Synthesis Inhibitors -- pharmacology KW - Enzyme Induction -- drug effects KW - Cells, Cultured KW - Cycloheximide -- pharmacology KW - Chick Embryo KW - Microsomes, Liver -- enzymology KW - Microsomes, Liver -- drug effects KW - Glutathione -- physiology KW - Uroporphyrinogens -- biosynthesis KW - RNA, Messenger -- biosynthesis KW - Hepatocytes -- drug effects KW - Oxidoreductases -- metabolism KW - Arsenites -- toxicity KW - Cytochrome P-450 Enzyme System -- metabolism KW - Cytochrome P-450 Enzyme System -- biosynthesis KW - Hepatocytes -- enzymology KW - Oxidoreductases -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72355552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Effect+of+arsenite+on+the+induction+of+CYP1A4+and+CYP1A5+in+cultured+chick+embryo+hepatocytes.&rft.au=Jacobs%2C+J+M%3BNichols%2C+C%3BMarek%2C+D%3BGorman%2C+N%3BWalton%2C+H+S%3BSinclair%2C+P+R%3BSinclair%2C+J+F&rft.aulast=Jacobs&rft.aufirst=J&rft.date=2000-11-01&rft.volume=168&rft.issue=3&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-04 N1 - Date created - 2000-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nutritional and health benefits of beer. AN - 70783222; 11093684 AB - Physicians should be aware of the growing evidence supporting the nutritional and health benefits of moderate consumption of alcohol as part of a healthy lifestyle. The recently approved voluntary label on wine ("the proud people who made this wine encourage you to consult your family doctor about the health effects of wine consumption") implies that physicians should promote wine as the preferred source of dietary alcohol. However, studies evaluating the relative benefits of wine versus beer versus spirits suggest that moderate consumption of any alcoholic beverage is associated with lower rates of cardiovascular disease. From a nutritional standpoint, beer contains more protein and B vitamins than wine. The antioxidant content of beer is equivalent to that of wine, but the specific antioxidants are different because the barley and hops used in the production of beer contain flavonoids different from those in the grapes used in the production of wine. The benefits of moderate alcohol consumption have not been generally endorsed by physicians for fear that heavy consumers may consider any message as a permissive license to drink in excess. Discussions with patients regarding alcohol consumption should be made in the context of a general medical examination. There is no evidence to support endorsement of one type of alcoholic beverage over another. The physician should define moderate drinking (1 drink per day for women and 2 drinks per day for men) for the patient and should review consumption patterns associated with high risk. JF - The American journal of the medical sciences AU - Denke, M A AD - Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas, Veterans Health Administration North Texas Health Care System, USA. mdenke@ednet.swmed.edu Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 320 EP - 326 VL - 320 IS - 5 SN - 0002-9629, 0002-9629 KW - Abridged Index Medicus KW - Index Medicus KW - Self Disclosure KW - Reproducibility of Results KW - Alcoholism -- diagnosis KW - Risk Factors KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Health Policy KW - Physician-Patient Relations KW - Alcoholism -- psychology KW - Male KW - Female KW - Beer -- analysis KW - Coronary Disease -- mortality KW - Nutritive Value KW - Coronary Disease -- diet therapy KW - Alcohol Drinking -- psychology KW - Alcohol Drinking -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70783222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Nutritional+and+health+benefits+of+beer.&rft.au=Denke%2C+M+A&rft.aulast=Denke&rft.aufirst=M&rft.date=2000-11-01&rft.volume=320&rft.issue=5&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-11 N1 - Date created - 2000-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improving treatment adherence in drug abusers who are HIV-positive. AN - 70607626; 16398004 AB - This article discusses the complex dual diagnosis of HIV/AIDS (Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome) and substance abuse, which affects a growing number of individuals worldwide. A brief review of HIV/AIDS is provided and the connection between HIV/AIDS and substance abuse is described. Substance abuse complicates both HIV/AIDS and its management because of the effects that illicit drugs have on various body systems and because of the behavioral disturbances that accompany substance use. For a variety of reasons adherence to treatment is poor in this population and several factors that negatively impact adherence are outlined. Treatment of drug abusers who are HIV-positive requires more flexibility than treating drug abuse and HIV separately. Because medication regimens can be complicated and demanding and nonadherence to treatment can cause mutation of the virus resulting in drug-resistant strains, it is essential to get the patient committed to treatment The goals of treatment are abstinence from illicit drugs, adherence to a treatment regimen, suppression of viral load, improved CD4 count, and improved quality of life. The role of the case manager is critical to improving treatment adherence. Essential attributes include knowledge of disease processes, critical thinking, and the ability to navigate the healthcare system. Case management interventions to improve treatment adherence should be directed at the patient, the regimen, the client-patient relationship, and the healthcare system. Because HIV/AIDS is now classified as a chronic disease and is no longer viewed as a death sentence, people who are HIV-positive have hope for longevity and a cure. It is this hope for a longer life and possible cure that can be used to motivate substance abusers who are HIV-infected to improve their treatment adherence and quality of life. JF - Lippincott's case management : managing the process of patient care AU - Malone, S B AU - Osborne, J J AD - Drug Dependence Treatment Program, Veterans Affairs Maryland Health Care System, 10 North Greene Street, Baltimore, MD 21201, USA. Sandra.Malone@med.va.gov PY - 2000 SP - 236 EP - 45; quiz 245-7 VL - 5 IS - 6 SN - 1529-7764, 1529-7764 KW - Nursing KW - Humans KW - Professional-Patient Relations KW - HIV Infections -- complications KW - Patient Compliance -- psychology KW - HIV Infections -- drug therapy KW - Antiretroviral Therapy, Highly Active KW - Substance-Related Disorders -- complications KW - Case Management KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70607626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lippincott%27s+case+management+%3A+managing+the+process+of+patient+care&rft.atitle=Improving+treatment+adherence+in+drug+abusers+who+are+HIV-positive.&rft.au=Malone%2C+S+B%3BOsborne%2C+J+J&rft.aulast=Malone&rft.aufirst=S&rft.date=2000-11-01&rft.volume=5&rft.issue=6&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Lippincott%27s+case+management+%3A+managing+the+process+of+patient+care&rft.issn=15297764&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-08 N1 - Date created - 2006-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sex Differences in Self-Reported and Physiological Response to Oral Cocaine and Placebo in Humans AN - 60396797; 200110717 AB - Self-report & physiological data from 27 male & 8 female cocaine-abusing volunteers exposed to cocaine (80 mg/70 kg po) & placebo were examined for sex differences in their responses. Females reported significantly greater baseline ratings on the Pentobarbital-Chlorpromazine-Alcohol Group (PCAG) (sedation) & Lysergic Acid Diethylamide (LSD) (dysphoria) subclass of the Addiction Research Center Inventory-Short Form (ARCI) relative to males. In addition, females reported significantly greater ratings on the Visual Analogs Scales (VAS) Bad Drug Effects & Anxious/Nervous scales relative to males, regardless of drug. Cocaine produced greater increase in systolic blood pressure in males following cocaine, whereas females showed greater increases in following placebos. These results suggest that a placebo control is necessary to determine sex differences in response to an active drug. 1 Table, 3 Figures, 26 References. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Singha, Amrita K AU - McCance-Katz, Elinore F AU - Petrakis, Ismene AU - Kosten, Thomas R AU - Oliveto, Alison AD - c/o Oliveto -- Dept Psychiatry, VA Connecticut Healthcare System, West Haven Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 643 EP - 657 VL - 26 IS - 4 SN - 0095-2990, 0095-2990 KW - Placebo Effect KW - Responses KW - Sex Differences KW - Cocaine KW - Connecticut KW - article KW - 2983: feminist/gender studies; sociology of gender & gender relations KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60396797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Sex+Differences+in+Self-Reported+and+Physiological+Response+to+Oral+Cocaine+and+Placebo+in+Humans&rft.au=Singha%2C+Amrita+K%3BMcCance-Katz%2C+Elinore+F%3BPetrakis%2C+Ismene%3BKosten%2C+Thomas+R%3BOliveto%2C+Alison&rft.aulast=Singha&rft.aufirst=Amrita&rft.date=2000-11-01&rft.volume=26&rft.issue=4&rft.spage=643&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Cocaine; Sex Differences; Responses; Placebo Effect; Connecticut ER - TY - JOUR T1 - Interaction of tetanus toxin derived hybrid proteins with neuronal cells AN - 17812202; 4856997 AB - The non-toxic ganglioside binding domain of tetanus toxin (Hc fragment C or TTC) has been studied as a vector for delivering therapeutic proteins to neurons. There is little information on the cellular processing of proteins delivered by linkage to TTC. We have evaluated the cellular handling of a multi-domain hybrid protein containing TTC and both the human enzyme superoxide dismutase and the maltose binding protein from E. coli. Binding, internalization, and cleavage of this protein during prolonged incubation with fetal cortical neurons or cells of the N18-RE-105 line was evaluated by immunoblot analysis, ELISA, and immunocytochemistry. Hybrid proteins were bound and internalized in a manner very similar to TTC. Internalized proteins showed long-term stability within cells, and were degraded into predictable large protein fragments in both cell types. Fragments that were cleaved away from the TTC domain were released into extracellular fluid after internalization. Proteins coupled to TTC share its long-term stability after cellular internalization. After internalization, dissociation of proteins linked to TTC facilitates their release from the cell, but not into other cellular compartments such as the cytosol. TTC linked proteins are probably enclosed within a stable endosomal compartment throughout their cellular lifetime. JF - Journal of Natural Toxins AU - Figueiredo, D M AU - Matthews, C C AU - Parks, DA AU - Fairweather, N F AU - Dougan, G AU - Wilt, S G AU - Fishman, P S AD - Neurology Service, Baltimore Veterans Administration Medical Center, Baltimore, MD 21201, USA, pfishman@umaryland.edu Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 363 EP - 379 VL - 9 IS - 4 SN - 1058-8108, 1058-8108 KW - maltose-binding protein KW - CSA Neurosciences Abstracts; Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Gangliosides KW - Tetanus KW - Toxins KW - Superoxide dismutase KW - Neurons KW - Escherichia coli KW - X 24171:Microbial KW - N3 11101:General KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17812202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Natural+Toxins&rft.atitle=Interaction+of+tetanus+toxin+derived+hybrid+proteins+with+neuronal+cells&rft.au=Figueiredo%2C+D+M%3BMatthews%2C+C+C%3BParks%2C+DA%3BFairweather%2C+N+F%3BDougan%2C+G%3BWilt%2C+S+G%3BFishman%2C+P+S&rft.aulast=Figueiredo&rft.aufirst=D&rft.date=2000-11-01&rft.volume=9&rft.issue=4&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Journal+of+Natural+Toxins&rft.issn=10588108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Toxins; Tetanus; Neurons; Gangliosides; Superoxide dismutase ER - TY - JOUR T1 - Evaluation of rifalazil in a combination treatment regimen as an alternative to isoniazid-rifampin therapy in a mouse tuberculosis model AN - 17642122; 4795101 AB - The newer rifamycin, rifalazil (RLZ) (previously known as KRM-1648), has been shown in prior experiments to be a highly potent drug against Mycobacterium tuberculosis. In this report, we studied the efficacy of RLZ in combination with pyrazinamide (PZA) and ethambutol (EMB) in a long-term in vivo experiment and compared their activity with the isoniazid (INH)-rifampin (RIF) combination which is presently used in the clinic. Combinations of RLZ with PZA alone or with both PZA and EMB were both found to have sterilizing activities comparable to that of the INH-RIF combination but significantly better activity with respect to relapse of infection. These results suggest that RLZ, or other agents with similar activity, could be combined with available agents to act as a potential alternative drug regimen to the currently used INH-RIF combination. JF - Antimicrobial Agents & Chemotherapy AU - Lenaerts, A M AU - Chase, ShE AU - Cynamon, M H AD - VAMC, 800 Irving Ave., Syracuse, NY 13210, USA, Michael.Cynamon@med.va.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 3167 EP - 3168 VL - 44 IS - 11 SN - 0066-4804, 0066-4804 KW - Pyrazinamide KW - Microbiology Abstracts B: Bacteriology KW - Rifampin KW - Animal models KW - Tuberculosis KW - Antibacterial agents KW - ethambutol KW - Rifamycins KW - Mycobacterium tuberculosis KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17642122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Evaluation+of+rifalazil+in+a+combination+treatment+regimen+as+an+alternative+to+isoniazid-rifampin+therapy+in+a+mouse+tuberculosis+model&rft.au=Lenaerts%2C+A+M%3BChase%2C+ShE%3BCynamon%2C+M+H&rft.aulast=Lenaerts&rft.aufirst=A&rft.date=2000-11-01&rft.volume=44&rft.issue=11&rft.spage=3167&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.44.11.3167-3168.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Tuberculosis; Animal models; Antibacterial agents; Rifamycins; ethambutol; Rifampin DO - http://dx.doi.org/10.1128/AAC.44.11.3167-3168.2000 ER - TY - JOUR T1 - Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice. AN - 72344399; 11032766 AB - CYP2E1 has been reported to have an essential role in alcohol-mediated increases in hepatic steatosis and acetaminophen hepatotoxicity. We found that pretreatment of Cyp2e1(-/-) mice with ethanol plus isopentanol, the predominant alcohols in alcoholic beverages, for 7 days resulted in micro- and macrovesicular steatosis in the livers of all mice, as well as a dramatic increase in acetaminophen hepatotoxicity. In Cyp2e1(-/-) mice administered up to 600 mg acetaminophen/kg alone and euthanized 7 h later, there was no increase in serum levels of ALT. In Cyp2e1(-/-) mice pretreated with ethanol and isopentanol, subsequent exposure to 400 or 600 mg acetaminophen/kg resulted in centrilobular necrosis in all mice with maximal elevation in serum levels of ALT. Acetaminophen-mediated liver damage was similar in males and females. Hepatic microsomal levels of APAP activation in untreated females were similar to those in males treated with the alcohols. However, the females, like the males, required pretreatment with the alcohols in order to increase APAP hepatotoxicity. These findings suggest that, in the Cyp2e1(-/-) mice, the alcohol-mediated increase in acetaminophen hepatotoxicity involves the contribution of other factors, in addition to induction of CYP(s) that activate acetaminophen. Alternatively, CYP-mediated activation of acetaminophen measured in vitro may not reflect the actual activity in vivo. Our findings that a 7-day treatment with ethanol and isopentanol causes extensive hepatic steatosis and increases acetaminophen hepatotoxicity in Cyp2e(-/-) mice indicate that CYP2E1 is not essential for either response. Copyright 2000 Academic Press. JF - Toxicology and applied pharmacology AU - Sinclair, J F AU - Szakacs, J G AU - Wood, S G AU - Walton, H S AU - Bement, J L AU - Gonzalez, F J AU - Jeffery, E H AU - Wrighton, S A AU - Bement, W J AU - Sinclair, P R AD - Veterans Administration Medical Center, White River Junction, Vermont, 05009, USA. JSINC@dartmouth.edu Y1 - 2000/10/15/ PY - 2000 DA - 2000 Oct 15 SP - 114 EP - 122 VL - 168 IS - 2 SN - 0041-008X, 0041-008X KW - Analgesics, Non-Narcotic KW - 0 KW - Benzoquinones KW - Imines KW - Pentanols KW - Acetaminophen KW - 362O9ITL9D KW - Ethanol KW - 3K9958V90M KW - isopentyl alcohol KW - DEM9NIT1J4 KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - N-acetyl-4-benzoquinoneimine KW - G6S9BN13TI KW - Index Medicus KW - Animals KW - Liver -- pathology KW - Liver -- enzymology KW - Sex Factors KW - Liver -- drug effects KW - Benzoquinones -- metabolism KW - Mice, Inbred C57BL KW - Mice KW - Liver Diseases -- enzymology KW - Drug Synergism KW - Imines -- metabolism KW - Male KW - Female KW - Biotransformation -- drug effects KW - Fatty Liver, Alcoholic -- enzymology KW - Analgesics, Non-Narcotic -- pharmacokinetics KW - Acetaminophen -- pharmacokinetics KW - Fatty Liver, Alcoholic -- etiology KW - Chemical and Drug Induced Liver Injury KW - Analgesics, Non-Narcotic -- toxicity KW - Ethanol -- toxicity KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Pentanols -- toxicity KW - Cytochrome P-450 CYP2E1 -- genetics KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72344399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Short-term+treatment+with+alcohols+causes+hepatic+steatosis+and+enhances+acetaminophen+hepatotoxicity+in+Cyp2e1%28-%2F-%29+mice.&rft.au=Sinclair%2C+J+F%3BSzakacs%2C+J+G%3BWood%2C+S+G%3BWalton%2C+H+S%3BBement%2C+J+L%3BGonzalez%2C+F+J%3BJeffery%2C+E+H%3BWrighton%2C+S+A%3BBement%2C+W+J%3BSinclair%2C+P+R&rft.aulast=Sinclair&rft.aufirst=J&rft.date=2000-10-15&rft.volume=168&rft.issue=2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-16 N1 - Date created - 2000-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulation of the bovine kidney microsomal chloride channel p64 by p59fyn, a Src family tyrosine kinase. AN - 72345652; 10930415 AB - p64 is a chloride channel of intracellular membranes which is present in regulated secretory vesicles. Mechanisms by which the p64 channel could be regulated are largely unknown. p59(fyn) is a non-receptor tyrosine kinase of the Src family that has been implicated in a variety of intracellular signaling events. The N-terminal portion of p64 has several potential binding sites for Src family SH2 domains. In this paper, we demonstrate that p64 becomes tyrosine phosphorylated when co-expressed with p59(fyn) in HeLa cells. We show that co-expression of p64 with p59(fyn) renders p64 a ligand for the SH2 domain of p59(fyn) and this SH2 binding is eliminated by treating p64 with alkaline phosphatase. Using site-directed mutagenesis, we find that tyrosine 33 in the p64 sequence is necessary for SH2 binding. We also characterized p64-p59(fyn) interactions using native material from bovine kidney. We found that a small fraction of native kidney p64 can bind Fyn SH2 in vitro. Immunoprecipitation of p64 from solubilized kidney membranes yields a kinase activity with the same mobility by SDS-polyacrylamide gel electrophoresis as authentic bovine p59(fyn). Finally, we demonstrate that co-expression of p64 and p59(fyn) in HeLa cells results in enhanced p64-associated chloride channel activity. JF - The Journal of biological chemistry AU - Edwards, J C AU - Kapadia, S AD - Renal Division, Department of Medicine, St. Louis University and the St. Louis Veterans Affairs Medical Center, St. Louis, Missouri 63106, USA. John.Edwards3@med.va.gov Y1 - 2000/10/13/ PY - 2000 DA - 2000 Oct 13 SP - 31826 EP - 31832 VL - 275 IS - 41 SN - 0021-9258, 0021-9258 KW - CLCNKA protein, human KW - 0 KW - Chloride Channels KW - Proto-Oncogene Proteins KW - Recombinant Fusion Proteins KW - Phosphotyrosine KW - 21820-51-9 KW - FYN protein, human KW - EC 2.7.10.2 KW - Proto-Oncogene Proteins c-fyn KW - src-Family Kinases KW - Index Medicus KW - Animals KW - Kidney -- metabolism KW - HeLa Cells KW - Humans KW - Gene Expression KW - Phosphotyrosine -- metabolism KW - Precipitin Tests KW - Protein Binding KW - src Homology Domains KW - Mutagenesis KW - Recombinant Fusion Proteins -- metabolism KW - Cattle KW - Phosphorylation KW - Transfection KW - src-Family Kinases -- genetics KW - Microsomes -- metabolism KW - src-Family Kinases -- metabolism KW - Proto-Oncogene Proteins -- metabolism KW - Chloride Channels -- metabolism KW - Proto-Oncogene Proteins -- genetics KW - Chloride Channels -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72345652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Regulation+of+the+bovine+kidney+microsomal+chloride+channel+p64+by+p59fyn%2C+a+Src+family+tyrosine+kinase.&rft.au=Edwards%2C+J+C%3BKapadia%2C+S&rft.aulast=Edwards&rft.aufirst=J&rft.date=2000-10-13&rft.volume=275&rft.issue=41&rft.spage=31826&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-13 N1 - Date created - 2000-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Approach to patients with refractory constipation. AN - 72540785; 10998666 AB - Constipation is a very frequent problem, particularly in elderly patients. Constipation is a common reason for patients to seek medical advice, and it accounts for a large number of different prescription and over-the-counter medications. In many cases, no definite cause can be found. Most patients respond to conservative therapy with increased fiber and fluid intake alone. Patients with constipation that is more difficult to control or with alarm symptoms (eg, blood in stool, sudden onset, weight loss, or decreasing stool caliber) warrant further investigation. A variety of medical, behavioral, and surgical therapies can be employed to help these more refractory patients. JF - Current gastroenterology reports AU - Wofford, S A AU - Verne, G N AD - Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Department of Medicine, Veterans Administration Medical Center, Research Service (151), 1601 SW Archer Road, Gainesville, FL 32608, USA. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 389 EP - 394 VL - 2 IS - 5 SN - 1522-8037, 1522-8037 KW - Cathartics KW - 0 KW - Narcotics KW - Index Medicus KW - Gastrointestinal Motility KW - Biofeedback, Psychology KW - Cathartics -- therapeutic use KW - Humans KW - Narcotics -- adverse effects KW - Dietary Fiber -- therapeutic use KW - Constipation -- diagnosis KW - Constipation -- etiology KW - Constipation -- therapy KW - Constipation -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72540785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+gastroenterology+reports&rft.atitle=Approach+to+patients+with+refractory+constipation.&rft.au=Wofford%2C+S+A%3BVerne%2C+G+N&rft.aulast=Wofford&rft.aufirst=S&rft.date=2000-10-01&rft.volume=2&rft.issue=5&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Current+gastroenterology+reports&rft.issn=15228037&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-17 N1 - Date created - 2001-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pure class III antiarrhythmic drugs: focus on dofetilide. AN - 72470730; 11150393 JF - Journal of cardiovascular pharmacology and therapeutics AU - Doshi, S K AU - Singh, B N AD - Veterans Administration Greater Los Angeles Health Care System, CA 90073, USA. skdoshi@ucla.edu Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 237 EP - 247 VL - 5 IS - 4 SN - 1074-2484, 1074-2484 KW - Anti-Arrhythmia Agents KW - 0 KW - Phenethylamines KW - Sulfonamides KW - dofetilide KW - R4Z9X1N2ND KW - Index Medicus KW - Animals KW - Humans KW - Heart Failure -- complications KW - Dogs KW - Disease Models, Animal KW - Electrophysiology KW - Sulfonamides -- pharmacokinetics KW - Phenethylamines -- pharmacokinetics KW - Phenethylamines -- adverse effects KW - Sulfonamides -- adverse effects KW - Sulfonamides -- pharmacology KW - Arrhythmias, Cardiac -- drug therapy KW - Anti-Arrhythmia Agents -- pharmacokinetics KW - Phenethylamines -- pharmacology KW - Anti-Arrhythmia Agents -- adverse effects KW - Anti-Arrhythmia Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72470730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.atitle=Pure+class+III+antiarrhythmic+drugs%3A+focus+on+dofetilide.&rft.au=Doshi%2C+S+K%3BSingh%2C+B+N&rft.aulast=Doshi&rft.aufirst=S&rft.date=2000-10-01&rft.volume=5&rft.issue=4&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.issn=10742484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-01 N1 - Date created - 2001-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antipyretic Therapy's future. AN - 72467619; 11113030 AB - There is little doubt that clinicians will continue to seek new and, one hopes, more intelligent ways to suppress fever. In the process, new agents will be developed, new uses will be identified for existing antipyretic agents, new measures will be designed to maximize the benefits of antipyretic therapy while minimizing its adverse effects, and a concerted effort will be made to define more clearly and to promote appropriate indications for such therapy. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Mackowiak, P A AD - Medical Care Clinical Center, VA Maryland Health Care System and the Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Philip.Mackowiak@med.va.gov Y1 - 2000/10// PY - 2000 DA - October 2000 SP - S242 EP - S243 VL - 31 Suppl 5 SN - 1058-4838, 1058-4838 KW - Analgesics, Non-Narcotic KW - 0 KW - Index Medicus KW - Humans KW - Forecasting KW - Drug Utilization KW - Drug Design KW - Risk Assessment KW - Analgesics, Non-Narcotic -- adverse effects KW - Analgesics, Non-Narcotic -- therapeutic use KW - Fever -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72467619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Antipyretic+Therapy%27s+future.&rft.au=Mackowiak%2C+P+A&rft.aulast=Mackowiak&rft.aufirst=P&rft.date=2000-10-01&rft.volume=31+Suppl+5&rft.issue=&rft.spage=S242&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diagnostic implications and clinical consequences of antipyretic therapy. AN - 72466330; 11113028 AB - It has been suggested that the response to antipyretic therapy might differentiate between fevers due to serious illness and fevers caused by less severe disorders; that neoplastic fevers are more responsive to nonsteroidal anti-inflammatory drugs than are infectious fevers; that the metabolic costs of fever can exceeds its clinical benefits; that antipyretic therapy can prevent or reverse febrile seizures in children and fever-associated mental dysfunction in frail elderly patients. This article examines the data on which these assertions are based. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Mackowiak, P A AD - Medical Care Clinical Center, VA Maryland Health Care System and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Philip.Mackowiak@med.va.gov Y1 - 2000/10// PY - 2000 DA - October 2000 SP - S230 EP - S233 VL - 31 Suppl 5 SN - 1058-4838, 1058-4838 KW - Analgesics, Non-Narcotic KW - 0 KW - Index Medicus KW - Neoplasms -- complications KW - Seizures, Febrile -- prevention & control KW - Humans KW - Seizures, Febrile -- chemically induced KW - Child KW - Bacterial Infections -- complications KW - Adolescent KW - Child, Preschool KW - Fever -- etiology KW - Analgesics, Non-Narcotic -- adverse effects KW - Analgesics, Non-Narcotic -- therapeutic use KW - Fever -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72466330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Diagnostic+implications+and+clinical+consequences+of+antipyretic+therapy.&rft.au=Mackowiak%2C+P+A&rft.aulast=Mackowiak&rft.aufirst=P&rft.date=2000-10-01&rft.volume=31+Suppl+5&rft.issue=&rft.spage=S230&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of LAAM and methadone utilization in an opiate agonist treatment program. AN - 72402115; 11064490 AB - The development and approval of levo-alpha-acetylmethadol (LAAM) as a pharmacotherapeutic agent in opioid agonist therapy provided an alternative to methadone. Clinicians recognized the potential benefits that LAAM, a synthetic mu agonist with pharmacological properties which differ from those of methadone,could have in the treatment management of addicts in opioid agonist therapy. We report our experience utilizing LAAM from 1995 to 1999 at the Hines VA opioid agonist therapy clinic. The addition of LAAM to the clinic's treatment armamentarium has resulted in management options that have improved the areas of patient recruitment, patient retention, patient traffic, take-home medication, detoxification, and treatment outcomes. JF - The Mount Sinai journal of medicine, New York AU - Valdivia, J F AU - Khattak, S AD - Drug Dependency Treatment Program, Building 228, Mail Code 116c, Hines Veterans Administration Hospital, Hines, IL 60141, USA. PY - 2000 SP - 398 EP - 403 VL - 67 IS - 5-6 SN - 0027-2507, 0027-2507 KW - Analgesics, Opioid KW - 0 KW - Methadyl Acetate KW - L59OC40KWJ KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Therapeutic Equivalency KW - Drug Tolerance KW - Methadone -- therapeutic use KW - Humans KW - Treatment Outcome KW - Patient Selection KW - Methadone -- pharmacology KW - Methadyl Acetate -- pharmacology KW - Analgesics, Opioid -- pharmacology KW - Analgesics, Opioid -- therapeutic use KW - Methadyl Acetate -- therapeutic use KW - Opioid-Related Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72402115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Mount+Sinai+journal+of+medicine%2C+New+York&rft.atitle=Effects+of+LAAM+and+methadone+utilization+in+an+opiate+agonist+treatment+program.&rft.au=Valdivia%2C+J+F%3BKhattak%2C+S&rft.aulast=Valdivia&rft.aufirst=J&rft.date=2000-10-01&rft.volume=67&rft.issue=5-6&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=The+Mount+Sinai+journal+of+medicine%2C+New+York&rft.issn=00272507&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-22 N1 - Date created - 2000-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Depression of retinal glutamate transporter function leads to elevated intravitreal glutamate levels and ganglion cell death. AN - 72296150; 11006260 AB - Elevated levels of extracellular glutamate have been implicated in the pathophysiology of neuronal loss in both central nervous system and ophthalmic disorders, including glaucoma. This increase in glutamate may result from a failure of glutamate transporters (molecules that ordinarily regulate extracellular glutamate; E:xcitatory A:mino A:cid T:ransporter; EAAT). Elevated glutamate levels can also lead to alterations in glutamate receptor expression. It was hypothesized that selective blockade of glutamate transporters would be toxic to retinal ganglion cells. Glutamate transporters were blocked either pharmacologically or with subtype-specific antisense oligonucleotides against EAAT1. Glutamate levels, transporter levels and ganglion cell survival were assayed. Pharmacological inhibition of glutamate transporters with either an EAAT2 specific inhibitor or a nonspecific inhibitor of all the subtypes of transporters was toxic to ganglion cells. Treatment with oligonucleotides against the glutamate transporter EAAT1 decreased the levels of expression of the transporter, increased vitreal glutamate, and was toxic to ganglion cells. These results demonstrate that normal function of EAAT1 and EAAT2 is necessary for retinal ganglion cell survival and plays an important role in retinal excitotoxicity. Manipulation of retinal glutamate transporter expression may become a useful tool in understanding retinal neuronal loss. JF - Investigative ophthalmology & visual science AU - Vorwerk, C K AU - Naskar, R AU - Schuettauf, F AU - Quinto, K AU - Zurakowski, D AU - Gochenauer, G AU - Robinson, M B AU - Mackler, S A AU - Dreyer, E B AD - Scheie Eye Institute, Philadelphia Veterans Administration, the University of Pennsylvania, Philadelphia 19104, USA. Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 3615 EP - 3621 VL - 41 IS - 11 SN - 0146-0404, 0146-0404 KW - Amino Acid Transport System X-AG KW - 0 KW - DNA Primers KW - Dicarboxylic Acids KW - Excitatory Amino Acid Transporter 2 KW - Neurotransmitter Uptake Inhibitors KW - Oligonucleotides, Antisense KW - Pyrrolidines KW - Receptors, Neurotransmitter KW - Glutamic Acid KW - 3KX376GY7L KW - dihydrokainic acid KW - 52497-36-6 KW - pyrrolidine-2,4-dicarboxylic acid KW - 99319-03-6 KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Rats KW - Animals KW - Blotting, Western KW - Rats, Long-Evans KW - Neurotransmitter Uptake Inhibitors -- pharmacology KW - Cell Death KW - Pyrrolidines -- pharmacology KW - Oligonucleotides, Antisense -- pharmacology KW - Dicarboxylic Acids -- pharmacology KW - Chromatography, High Pressure Liquid KW - DNA Primers -- chemistry KW - Receptors, Neurotransmitter -- physiology KW - Kainic Acid -- pharmacology KW - Kainic Acid -- analogs & derivatives KW - Glutamic Acid -- metabolism KW - Vitreous Body -- metabolism KW - ATP-Binding Cassette Transporters -- physiology KW - Receptors, Neurotransmitter -- antagonists & inhibitors KW - Retinal Ganglion Cells -- pathology KW - ATP-Binding Cassette Transporters -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72296150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Depression+of+retinal+glutamate+transporter+function+leads+to+elevated+intravitreal+glutamate+levels+and+ganglion+cell+death.&rft.au=Vorwerk%2C+C+K%3BNaskar%2C+R%3BSchuettauf%2C+F%3BQuinto%2C+K%3BZurakowski%2C+D%3BGochenauer%2C+G%3BRobinson%2C+M+B%3BMackler%2C+S+A%3BDreyer%2C+E+B&rft.aulast=Vorwerk&rft.aufirst=C&rft.date=2000-10-01&rft.volume=41&rft.issue=11&rft.spage=3615&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-12 N1 - Date created - 2000-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pharmacodynamic study of clopidogrel in chronic hemodialysis patients. AN - 72295979; 11005934 AB - Combination antiplatelet agents, particularly aspirin and ticlopidine, have found increased use in the prevention of arterial thrombosis. Clopidogrel, a thienopyridine derivative, like ticlopidine was recently approved by the U.S. Food and Drug Administration (FDA) for the reduction of ischemic events in patients with myocardial infarction, stroke, or peripheral arterial disease and appears to have much less hematologic toxicity than ticlopidine has. Thrombosis of hemodialysis access grafts is a major cause of morbidity in this patient population. Combination antiplatelet agents may be particularly useful in the prevention of hemodialysis access graft thrombosis. In preparation for such a study, we have performed a pharmacodynamic study of the platelet inhibitory effects of clopidogrel in patients on maintenance hemodialysis. Nine chronic hemodialysis patients were studied. Baseline platelet aggregation studies were performed, after which the subjects were begun on clopidogrel 75 mg daily. Platelet aggregation studies were repeated after 14 days of therapy. Drug was stopped and a final set of platelet aggregation studies were performed 7 days later. Because clopidogrel acts by inhibiting adenosine diphosphate (ADP)-induced platelet aggregation, we used ADP as the agonist in the platelet aggregation studies. We also measured the time required to achieve hemostasis after removing the dialysis needles at the termination of a dialysis session. Patients were carefully monitored for any adverse reaction to clopidogrel. Fourteen days' treatment with clopidogrel inhibited ADP-induced platelet aggregation from 48 to 23% with ADP 2 microM (P=0.0113), from 59 to 38% with ADP 5 microM (P=0. 0166), and from 66 to 44% with ADP 10 microM (P=0. 0172). This inhibition of platelet aggregation was reversed 7 days after stopping clopidogrel. Clopidogrel administration did not affect the time required to achieve hemostasis after removal of the dialysis needles. No adverse reactions were noted. No patient had evidence of bleeding, rash or gastro-intestinal (GI) upset. Clopidogrel inhibits ADP-induced platelet aggregation in subjects receiving chronic maintenance hemodialysis. The magnitude of inhibition is similar to that reported in nonuremic subjects with atherosclerosis. This inhibition is reversible within 7 days of discontinuing the drug. No adverse reactions to the drug were noted in this short-term (14-day) trial. JF - Journal of thrombosis and thrombolysis AU - Kaufman, J S AU - Fiore, L AU - Hasbargen, J A AU - O'Connor, T Z AU - Perdriset, G AD - Renal Section, VA Boston Healthcare System, Boston, Massachusetts 02130, USA. kaufman.james@boston.va.gov Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 127 EP - 131 VL - 10 IS - 2 SN - 0929-5305, 0929-5305 KW - Platelet Aggregation Inhibitors KW - 0 KW - Adenosine Diphosphate KW - 61D2G4IYVH KW - clopidogrel KW - A74586SNO7 KW - Ticlopidine KW - OM90ZUW7M1 KW - Index Medicus KW - Thrombosis -- prevention & control KW - Platelet Function Tests KW - Renal Insufficiency -- therapy KW - Dose-Response Relationship, Drug KW - Humans KW - Hemostasis -- drug effects KW - Thrombosis -- etiology KW - Platelet Aggregation Inhibitors -- pharmacology KW - Pilot Projects KW - Chronic Disease KW - Arterial Occlusive Diseases -- etiology KW - Adenosine Diphosphate -- pharmacology KW - Arterial Occlusive Diseases -- prevention & control KW - Renal Insufficiency -- complications KW - Platelet Aggregation -- drug effects KW - Ticlopidine -- pharmacology KW - Ticlopidine -- analogs & derivatives KW - Renal Dialysis -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72295979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+thrombosis+and+thrombolysis&rft.atitle=A+pharmacodynamic+study+of+clopidogrel+in+chronic+hemodialysis+patients.&rft.au=Kaufman%2C+J+S%3BFiore%2C+L%3BHasbargen%2C+J+A%3BO%27Connor%2C+T+Z%3BPerdriset%2C+G&rft.aulast=Kaufman&rft.aufirst=J&rft.date=2000-10-01&rft.volume=10&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Journal+of+thrombosis+and+thrombolysis&rft.issn=09295305&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-09 N1 - Date created - 2001-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Educating Social Workers for an Aging Society: A Vision for the 21st Century AN - 61315247; 200100294 AB - The unprecedented demographic shift to an increasingly older society will have a dramatic impact on individual choices over the life course, the structure of the family, & multiple social institutions. Social work can make unique professional contributions to older persons & the late-life family. Arguing that social work is not adequately prepared to practice in the aging society, challenges to social work are identified, along with ways to address these challenges through educational innovations. 1 Figure, 44 References. Adapted from the source document. JF - Journal of Social Work Education AU - Scharlach, Andrew AU - Damron-Rodriguez, JoAnn AU - Robinson, Barrie AU - Feldman, Ronald AD - Dept Social Welfare, School Public Policy & Social Research, U California, Los Angeles Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 521 EP - 538 VL - 36 IS - 3 SN - 1043-7797, 1043-7797 KW - Twenty First Century KW - Curriculum KW - Social Work Education KW - Demographic Change KW - Aging KW - Gerontology KW - article KW - 6113: social work education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61315247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+Work+Education&rft.atitle=Educating+Social+Workers+for+an+Aging+Society%3A+A+Vision+for+the+21st+Century&rft.au=Scharlach%2C+Andrew%3BDamron-Rodriguez%2C+JoAnn%3BRobinson%2C+Barrie%3BFeldman%2C+Ronald&rft.aulast=Scharlach&rft.aufirst=Andrew&rft.date=2000-10-01&rft.volume=36&rft.issue=3&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+Work+Education&rft.issn=10437797&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-10-30 N1 - Last updated - 2016-09-28 N1 - CODEN - JSWEED N1 - SubjectsTermNotLitGenreText - Demographic Change; Aging; Social Work Education; Gerontology; Curriculum; Twenty First Century ER - TY - JOUR T1 - Pregnancy outcomes among U.S. women Vietnam veterans AN - 18005048; 4773336 AB - Since the 1965-1975 Vietnam War, there has been persistent concern that women who served in the U.S. military in Vietnam may have experienced adverse pregnancy outcomes. We compared self-reported pregnancy outcomes for 4,140 women Vietnam veterans with those of 4,140 contemporary women veterans who were not deployed to Vietnam. As a measure of association, we calculated odds ratios (OR) and 95% confidence intervals (CI) using logistic regression adjusting for age at conception, race, education, military nursing status, smoking, drinking and other exposures during pregnancy. There was no statistically significant association between military service in Vietnam and index pregnancies resulting in miscarriage or stillbirth, low birth weight, pre-term delivery, or infant death. The risk of having children with "moderate-to-severe" birth defects was significantly elevated among Vietnam veterans (adjusted OR = 1.46, 95% CI = 1.06-2.02). The risk of birth defects among index children was significantly associated with mother's military service in Vietnam. JF - American Journal of Industrial Medicine AU - Kang, H K AU - Mahan, C M AU - Lee, KY AU - Magee, CA AU - Mather, SH AU - Matanoski, G AD - Environmental Epidemiology Service, Department of Veterans Affairs, 1120 20th Street N.W., Suite 950, Washington, DC 20036-3406, USA, han.kang@mail.va.gov Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 447 EP - 454 VL - 38 IS - 4 SN - 0271-3586, 0271-3586 KW - veterans KW - man KW - females KW - Vietnam KW - Vietnam War KW - low-birth-weight KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Pregnancy KW - Hazardous materials KW - War KW - Congenital defects KW - Reproduction KW - Females KW - Military KW - Military personnel KW - Occupational exposure KW - X 24240:Miscellaneous KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18005048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Pregnancy+outcomes+among+U.S.+women+Vietnam+veterans&rft.au=Kang%2C+H+K%3BMahan%2C+C+M%3BLee%2C+KY%3BMagee%2C+CA%3BMather%2C+SH%3BMatanoski%2C+G&rft.aulast=Kang&rft.aufirst=H&rft.date=2000-10-01&rft.volume=38&rft.issue=4&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Occupational exposure; Hazardous materials; Military; Pregnancy; Females; Congenital defects; Military personnel; War; Reproduction ER - TY - JOUR T1 - Induction of MMP-9 mediated gelatinolytic activity in human monocytic cells by cell wall components of M. tuberculosis AN - 17688405; 4772078 AB - Mycobacterium tuberculosis (Mtb) infection induces the expression of host matrix metalloIproteinases (MMPs) capable of tissue degradation. We show that infection of mice with Mtb results in differential expression of MMPs in the lung. MMP-9 activity increased by week 1 post-infection, while MMP-2 activity increased after week 2. RT-PCR analysis for gene expression of gelatinases and their respective inhibitors showed: a small increase in MMP-9 by week 1, no change in TIMP-1 and MMP-2, and a significant decrease in TIMP-2 by week 4. The increase in MMP-2 could be due to a decrease in TIMP-2 expression. Addition of 4-aminophenylmercuric acid to lung extracts increased MMP-9 activity, suggesting that its regulation could be due to endogenous activation by proteases. In vitro, attenuated and virulent Mtb strains equally induced MMP-9 expression in U937 monocytes. The inducer of MMP-9 in Mtb was present in culture filtrates, and was active after paraformaldehyde fixation. LAM stimulated MMP-9 expression in THP-1 cells, but not U937 cells. However, LAM-free extracts also induced MMP-9 activity in THP-1 cells. Fractionation of Mtb extracts by chromatography revealed fractions of 17 and 156 kDa with MMP-9 inducing activity. In conclusion, LAM and other components of Mtb induce the expression of MMP-9. JF - Microbial Pathogenesis AU - Rivera-Marrero, CA AU - Schuyler, W AU - Roser, S AU - Roman, J AD - Department of Medicine, Pulmonary and Critical Care Division, Atlanta, 30033, GA, U.S.A., roman-rodriguez.jesse@atlanta.va.gov Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 231 EP - 244 PB - Academic Press VL - 29 IS - 4 SN - 0882-4010, 0882-4010 KW - gelatinase KW - matrix metalloproteinase KW - Microbiology Abstracts B: Bacteriology KW - Gene expression KW - Metalloproteinase KW - Cell walls KW - Mycobacterium tuberculosis KW - J 02728:Enzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17688405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Induction+of+MMP-9+mediated+gelatinolytic+activity+in+human+monocytic+cells+by+cell+wall+components+of+M.+tuberculosis&rft.au=Rivera-Marrero%2C+CA%3BSchuyler%2C+W%3BRoser%2C+S%3BRoman%2C+J&rft.aulast=Rivera-Marrero&rft.aufirst=CA&rft.date=2000-10-01&rft.volume=29&rft.issue=4&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Metalloproteinase; Cell walls; Gene expression ER - TY - JOUR T1 - Activity of ABT-773 against Mycobacterium avium complex in the beige mouse model AN - 17641513; 4784082 AB - ABT-773, a new ketolide antimicrobial agent, was evaluated in comparison to clarithromycin (CLA) in vitro against Mycobacterium avium complex (MAC) and in a beige mouse model of disseminated MAC infection. The MICs at which 50 and 90% of the isolates tested were inhibited were 2 and 4 mu g/ml, respectively, for CLA and 8 and 16 mu g/ml, respectively, for ABT-773. Eight CLA-resistant isolates were found to be resistant to ABT-773 (MICs > 64 mu g/ml). In the in vivo study mice were treated with ABT-773 (50, 100, and 200 mg/kg of body weight) or CLA (200 mg/kg). Both ABT-773 (100 and 200 mg/kg) and CLA significantly decreased the viable cell counts in spleens and lungs. ABT-773 (200 mg/kg) and CLA had similar activities in lungs, but the former was more active in spleens. JF - Antimicrobial Agents & Chemotherapy AU - Cynamon, M H AU - Carter, J L AU - Shoen, C M AD - Department of Medicine, Veterans Affairs Medical Center, 800 Irving Ave., Syracuse, NY 13210, USA, Michael.Cynamon@Med.VA.Gov Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 2895 EP - 2896 VL - 44 IS - 10 SN - 0066-4804, 0066-4804 KW - ABT-773 KW - Microbiology Abstracts B: Bacteriology KW - Clarithromycin KW - Mycobacterium avium KW - Drug resistance KW - Animal models KW - Drug sensitivity testing KW - Antibacterial agents KW - Minimum inhibitory concentration KW - J 02786:Macrolide antibiotics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17641513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Activity+of+ABT-773+against+Mycobacterium+avium+complex+in+the+beige+mouse+model&rft.au=Cynamon%2C+M+H%3BCarter%2C+J+L%3BShoen%2C+C+M&rft.aulast=Cynamon&rft.aufirst=M&rft.date=2000-10-01&rft.volume=44&rft.issue=10&rft.spage=2895&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.44.10.2895-2896.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium avium; Antibacterial agents; Clarithromycin; Drug sensitivity testing; Minimum inhibitory concentration; Drug resistance; Animal models DO - http://dx.doi.org/10.1128/AAC.44.10.2895-2896.2000 ER - TY - JOUR T1 - Diesel exhaust exposure and lung cancer: Adjustment for the effect of smoking in a retrospective cohort study AN - 17630402; 4773309 AB - The extent that cigarette smoking may confound the relationship between diesel exhaust exposure and lung cancer was assessed in a retrospective cohort study of 55,395 U.S. railroad workers followed from 1959 to 1976. The relative risk (RR) of lung cancer due to diesel exhaust was indirectly adjusted using job-specific smoking data from a case-control study of railroad workers who died between 1981-1982 and from a survey of 514 living workers from an active railroad in 1982. Adjustment factors were developed based on the distribution of job-specific smoking rates. The unadjusted RR for lung cancer was 1.58 (95% CI = 1.14-2.20) for workers aged 40-44 in 1959, who experienced the longest possible duration of exposure, and the smoking adjusted RR was 1.44 (1.01-2.05). After considering differences in smoking rates between workers exposed and unexposed to diesel exhaust in a relatively large blue-collar cohort, there were still elevated risks of lung cancer in workers in jobs with diesel exhaust exposure. JF - American Journal of Industrial Medicine AU - Larkin, E K AU - Smith, T J AU - Stayner, L AU - Rosner, B AU - Speizer, F E AU - Garshick, E AD - MOH Medical and Research Service, VA Boston Health Care Systems, 1400 UFW Parkway, Boston, MA 02132, USA, eric.garshick@med.va.gov Y1 - 2000/10// PY - 2000 DA - Oct 2000 SP - 399 EP - 409 VL - 38 IS - 4 SN - 0271-3586, 0271-3586 KW - man KW - railroads KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts; Risk Abstracts KW - lung cancer KW - Railroads KW - Cigarette smoking KW - Occupational exposure KW - Exhaust emissions KW - Lung cancer KW - Exhausts KW - Diesel KW - Diesel engines KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17630402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Diesel+exhaust+exposure+and+lung+cancer%3A+Adjustment+for+the+effect+of+smoking+in+a+retrospective+cohort+study&rft.au=Larkin%2C+E+K%3BSmith%2C+T+J%3BStayner%2C+L%3BRosner%2C+B%3BSpeizer%2C+F+E%3BGarshick%2C+E&rft.aulast=Larkin&rft.aufirst=E&rft.date=2000-10-01&rft.volume=38&rft.issue=4&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2F1097-0274%28200010%2938%3A43.3.CO%3B2-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lung cancer; Cigarette smoking; Occupational exposure; Diesel engines; Exhaust emissions; Railroads; Exhausts; Diesel; lung cancer DO - http://dx.doi.org/10.1002/1097-0274(200010)38:4<399::AID-AJIM5>3.3.CO;2-4 ER - TY - JOUR T1 - Improving Residents' Compliance With Standards of Ambulatory Care. Results From the VA Cooperative Study on Computerized Reminders AN - 18339776; 4862627 AB - Computerized systems to remind physicians to provide appropriate care have not been widely evaluated in large numbers of patients in multiple clinical settings. To examine whether a computerized reminder system operating in multiple Veterans Affairs (VA) ambulatory care clinics improves resident physician compliance with standards of ambulatory care. A total of 275 resident physicians at 12 VA medical centers were randomly assigned in firms or half-day clinic blocks to either a reminder group (n = 132) or a control group (n = 143). During a 17-month study period (January 31, 1995-June 30, 1996), the residents cared for 12,989 unique patients for whom at least 1 of the studied standards of care (SOC) was applicable. Compliance with 13 SOC, tracked using hospital databases and encounter forms completed by residents, compared between residents in the reminder group vs those in the control group. Measuring compliance as the proportion of patients in compliance with all applicable SOC by their last visit during the study period, the reminder group had statistically significantly higher rates of compliance than the control group for all standards combined (58.8% vs 53.5%; odds ratio [OR], 1.24; 95% confidence interval [CI], 1.08-1.42; P = .002) and for 5 of the 13 standards examined individually. Measuring compliance as the proportion of all visits for which care was indicated in which residents provided proper care, the reminder group also had statistically significantly higher rates of compliance than the control group for all standards combined (17.9% vs 12.2%; OR, 1.57; 95% CI, 1.45-1.71; P<.001) and for 9 of the 13 standards examined individually. The benefit of reminders, however, declined throughout the course of the study, even though the reminders remained active. Our data indicate that reminder systems installed at multiple sites can improve residents' compliance to multiple SOC. The benefits of such systems, however, appear to deteriorate over time. Future research needs to explore methods to better sustain the benefits of reminders. JF - Journal of the American Medical Association AU - Demakis, J G AU - Beauchamp, C AU - Cull, W L AU - Denwood, R AU - Eisen, SA AU - Lofgren, R AU - Nichol, K AU - Woolliscroft, J AU - Henderson, W G AD - (151K), Hines VA Hospital, PO Box 5000, Hines, IL 60141, USA, Henderson@research.hines.med.va.gov Y1 - 2000/09/20/ PY - 2000 DA - 2000 Sep 20 SP - 1411 EP - 1416 VL - 284 IS - 11 SN - 0098-7484, 0098-7484 KW - Health & Safety Science Abstracts KW - Health care KW - Quality control KW - Compliance KW - Standards KW - H 13000:Medical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18339776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Association&rft.atitle=Improving+Residents%27+Compliance+With+Standards+of+Ambulatory+Care.+Results+From+the+VA+Cooperative+Study+on+Computerized+Reminders&rft.au=Demakis%2C+J+G%3BBeauchamp%2C+C%3BCull%2C+W+L%3BDenwood%2C+R%3BEisen%2C+SA%3BLofgren%2C+R%3BNichol%2C+K%3BWoolliscroft%2C+J%3BHenderson%2C+W+G&rft.aulast=Demakis&rft.aufirst=J&rft.date=2000-09-20&rft.volume=284&rft.issue=11&rft.spage=1411&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Health care; Standards; Quality control; Compliance ER - TY - JOUR T1 - Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use. AN - 72278141; 10995858 AB - Using a model of recreational cocaine consumption, we have determined in four rhesus monkeys the impact of self-administered cocaine on mesolimbic and sensorimotor striatal dopaminergic neurotransmission. The effects of cocaine repeated within a self-administration session and across multiple sessions over a 6 month period were determined by the use of fixed-ratio self-administration and microdialysis procedures. The exposure to cocaine was modest, with at most two 0.5 mg/kg infusions permitted in each weekly session. Within a cocaine self-administration session, acute tolerance to the ability of cocaine to elevate extracellular striatal dopamine was observed. Over a period of 6 months of repeated self-administration, there was a significant increase in the impact of a fixed dose on extracellular dopamine, indicating that neurochemical sensitization to the effects of self-administered cocaine occurs in primates. A pronounced dopaminergic response to noncontingent cocaine was also observed, with no increases in extracellular dopamine in response to an unexpected saline substitution, indicating that the neurochemical response to self-administered cocaine is primarily caused by direct pharmacological effects of the drug rather than by conditioning to external environmental cues. These results highlight the contrast in time-dependent changes in neurochemical responsiveness to cocaine, depending on whether within-session or between-session comparisons are made. They also demonstrate that recreational levels of cocaine consumption can result in neurochemical sensitization, an enduring change in brain function that may contribute to addiction. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Bradberry, C W AD - Departments of Psychiatry and Laboratory Medicine, West Haven Veterans Administration Hospital and Yale University School of Medicine, West Haven, Connecticut 06516, USA. charles.bradberry@yale.edu Y1 - 2000/09/15/ PY - 2000 DA - 2000 Sep 15 SP - 7109 EP - 7115 VL - 20 IS - 18 SN - 0270-6474, 0270-6474 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Acute Disease KW - Regression Analysis KW - Animals KW - Analysis of Variance KW - Extracellular Space -- chemistry KW - Corpus Striatum -- metabolism KW - Disease Models, Animal KW - Microdialysis KW - Behavior, Animal -- drug effects KW - Drug Tolerance KW - Self Administration KW - Extracellular Space -- metabolism KW - Chronic Disease KW - Macaca mulatta KW - Male KW - Synaptic Transmission -- drug effects KW - Dopamine -- metabolism KW - Dopamine -- analysis KW - Cocaine-Related Disorders -- metabolism KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72278141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Acute+and+chronic+dopamine+dynamics+in+a+nonhuman+primate+model+of+recreational+cocaine+use.&rft.au=Bradberry%2C+C+W&rft.aulast=Bradberry&rft.aufirst=C&rft.date=2000-09-15&rft.volume=20&rft.issue=18&rft.spage=7109&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-18 N1 - Date created - 2000-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment of uninvestigated dyspepsia with cisapride for patients with negative Helicobacter pylori serologies. AN - 85349485; pmid-11007220 AB - OBJECTIVE: The aim of this study was to compare symptoms for patients with uninvestigated dyspepsia and a negative Helicobacter pylori serology who were treated with cisapride or placebo. METHODS: Helicobacter pylori-seronegative patients with chronic dyspepsia were randomized to receive cisapride 10 mg t.i.d. or placebo t.i.d. for 30 days. Symptom scores were performed 1 month and 3 months after randomization. Outcomes measured were dyspepsia symptom scores and a treatment "success" variable defined as absence of symptoms or decrease in the most severe individual symptom by two grades. RESULTS: A total of 60 patients were randomized; 56 completed the 1-month follow-up and 40 completed the 3-month follow-up interview. The mean score for all patients at the time of entry was 11.0 and declined to 8.3 and 8.2 at 1 and 3 months, respectively, after randomization. At 1 month and 3 months after randomization, there was no significant difference in the number of patients meeting the "success" variable for patients receiving cisapride as compared to placebo. The mean decline in symptom severity scores was not significantly different for patients receiving placebo or cisapride at 1 month (mean, -2.8 vs -3.1; difference = 0.3, p = 0.74) or 3 months (-3.1 vs -2.6, difference = -0.5, p = 0.58) after randomization. CONCLUSIONS: No significant difference in the severity of dyspeptic symptoms was found for patients receiving cisapride as compared to placebo in the setting of uninvestigated dyspepsia and a negative Helicobacter pylori serology. JF - The American journal of gastroenterology AU - Kearney, D J AU - Avins, A L AU - McQuaid, K R AD - San Francisco Veterans Administration Medical Center, University of California-San Francisco, USA. Y1 - 2000/09// PY - 2000 DA - Sep 2000 SP - 2212 EP - 2217 VL - 95 IS - 9 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Severity of Illness Index KW - Administration, Oral KW - Helicobacter Infections -- diagnosis KW - Diagnosis, Differential KW - Gastrointestinal Agents -- administration & dosage KW - Humans KW - Cisapride -- administration & dosage KW - Helicobacter Infections -- microbiology KW - Dyspepsia -- drug therapy KW - Dyspepsia -- etiology KW - Immunoglobulin G -- immunology KW - Adult KW - Cisapride -- therapeutic use KW - Gastrointestinal Agents -- therapeutic use KW - Male KW - Female KW - Dyspepsia -- diagnosis KW - Antibodies, Bacterial -- analysis KW - Helicobacter pylori -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85349485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Treatment+of+uninvestigated+dyspepsia+with+cisapride+for+patients+with+negative+Helicobacter+pylori+serologies.&rft.au=Kearney%2C+D+J%3BAvins%2C+A+L%3BMcQuaid%2C+K+R&rft.aulast=Kearney&rft.aufirst=D&rft.date=2000-09-01&rft.volume=95&rft.issue=9&rft.spage=2212&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - The role of physical proximity in nosocomial diarrhea. AN - 72408418; 11017821 AB - To examine physical proximity as a risk factor for the nosocomial acquisition of Clostridium difficile-associated diarrhea (CDAD) and of antibiotic-associated diarrhea (AAD), we assessed a retrospective cohort of 2859 patients admitted to a community hospital from 1 March 1987 through 31 August 1987. Of these patients, 68 had nosocomial CDAD and 54 had nosocomial AAD. In multivariate analysis, physical proximity to a patient with CDAD (relative risk [RR], 1.86; 95% confidence interval [CI], 1.06-3.28), exposure to clindamycin (RR, 4.22; 95% CI, 2.11-8.45), and the number of antibiotics taken (RR, 1.49; 95% CI, 1.23-1.81) were significant. For patients with nosocomial AAD, exposure to a roommate with AAD (RR, 3.94; 95% CI, 1. 27-12.24), a stay in an intensive care unit or cardiac care unit (RR, 1.93; 95% CI, 1.05-3.53), and the number of antibiotics taken (RR, 2.01; 95% CI, 1.67-2.40) were significant risk factors. Physical proximity may be an independent risk factor for acquisition of nosocomial CDAD and AAD. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Chang, V T AU - Nelson, K AD - Department of Medicine, Veterans Affairs New Jersey Health Care System at East Orange/University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ 07019, USA. victor.chang@med. va.gov Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 717 EP - 722 VL - 31 IS - 3 SN - 1058-4838, 1058-4838 KW - Anti-Bacterial Agents KW - 0 KW - Index Medicus KW - Humans KW - Anti-Bacterial Agents -- adverse effects KW - Retrospective Studies KW - Aged KW - Clostridium Infections -- microbiology KW - Multivariate Analysis KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Cohort Studies KW - Clostridium difficile KW - Middle Aged KW - Female KW - Hospitals, Community -- statistics & numerical data KW - Male KW - Diarrhea -- chemically induced KW - Environmental Exposure KW - Cross Infection -- microbiology KW - Diarrhea -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72408418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=The+role+of+physical+proximity+in+nosocomial+diarrhea.&rft.au=Chang%2C+V+T%3BNelson%2C+K&rft.aulast=Chang&rft.aufirst=V&rft.date=2000-09-01&rft.volume=31&rft.issue=3&rft.spage=717&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-22 N1 - Date created - 2000-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence and diagnostic value of precordial murmurs for valvular regurgitation in obese patients treated with dexfenfluramine. AN - 72293715; 11009272 AB - Echocardiography is recommended for the detection of valvular regurgitation in asymptomatic users of anorexigens with a heart murmur. To determine the prevalence and diagnostic value of heart murmurs for valvular regurgitation, 223 patients receiving dexfenfluramine therapy for 6.9 months and 189 matched controls underwent history and cardiac auscultation by experienced noncardiologists unaware of echocardiography. Color Doppler echocardiograms were interpreted by 3 observers unaware of patients' clinical data. The frequency of at least mild regurgitation of any valve and abnormal regurgitation (moderate mitral or tricuspid or mild aortic regurgitation) were determined. Heart murmurs heard in 31 dexfenfluramine users (14%) and in 20 controls (11%) were all systolic and of grade I to II/VI intensity. Mild or worse regurgitation of any valve showed a trend in patients (18% vs 11.6% in controls, odds ratio [OR] 1.66, confidence interval [CI] 0.95 to 2.9, p = 0.08), but abnormal regurgitation (includes Food and Drug Administration grade regurgitation) was more common in patients (9% vs 3% in controls, OR 3.0, CI 1.18 to 7.65, p = 0.02). In dexfenfluramine users, heart murmurs were associated with at least mild or abnormal regurgitation (OR 3.1 and 3.05, 95% CI 1.34 to 7.13 and 1.1 to 8.67; p = 0.008 and 0.036, respectively), had a specificity of 89% and 88%, negative predictive value of 85% and 93%, but sensitivity of 37% and 30%, and positive predictive value of 35% and 19%, respectively. Most valves missed by cardiac auscultation had normal morphology and mild regurgitation. Finally, heart murmurs had better diagnostic value for either type of valvular regurgitation than heart murmurs and clinical variables or clinical variables alone. In summary, in dexfenfluramine users the prevalence of heart murmurs was low and their absence predicted absence of mild or worse regurgitation of any valve or abnormal valvular regurgitation. Therefore, cardiac auscultation should be the screening method of choice for detecting valvular regurgitation in users of anorexigens. JF - The American journal of cardiology AU - Roldan, C A AU - Gill, E A AU - Shively, B K AD - Cardiology Division of the Veterans Affairs Medical Center and University of New Mexico, Albuquerque 87108, USA. roldan.carlos-a@albuquerque.va.gov Y1 - 2000/09/01/ PY - 2000 DA - 2000 Sep 01 SP - 535 EP - 539 VL - 86 IS - 5 SN - 0002-9149, 0002-9149 KW - Serotonin Receptor Agonists KW - 0 KW - Dexfenfluramine KW - E35R3G56OV KW - Abridged Index Medicus KW - Index Medicus KW - Echocardiography, Doppler, Color KW - Humans KW - Case-Control Studies KW - Middle Aged KW - Heart Auscultation KW - Male KW - Female KW - Prevalence KW - Obesity -- drug therapy KW - Heart Valve Diseases -- diagnosis KW - Serotonin Receptor Agonists -- adverse effects KW - Heart Valve Diseases -- complications KW - Heart Murmurs -- diagnosis KW - Heart Murmurs -- etiology KW - Dexfenfluramine -- adverse effects KW - Heart Valve Diseases -- chemically induced KW - Obesity -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72293715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Prevalence+and+diagnostic+value+of+precordial+murmurs+for+valvular+regurgitation+in+obese+patients+treated+with+dexfenfluramine.&rft.au=Roldan%2C+C+A%3BGill%2C+E+A%3BShively%2C+B+K&rft.aulast=Roldan&rft.aufirst=C&rft.date=2000-09-01&rft.volume=86&rft.issue=5&rft.spage=535&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-05 N1 - Date created - 2000-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. AN - 72240307; 10977010 AB - Of patients who are prescribed metformin, 10-30% have evidence of reduced vitamin B12 absorption. B12-intrinsic factor complex uptake by ileal cell surface receptors is known to be a process dependent on calcium availability Metformin affects calcium-dependent membrane action. The objective of this study was to determine the magnitude and mechanism of the reduction in serum vitamin B12 after metformin administration. A comparative study design was employed using 2 groups (metformin and control). A total of 21 patients with type 2 diabetes received sulfonylurea therapy; 14 of these 21 patients were switched to metformin. Monthly serum total vitamin B12 measurements and holotranscobalamin (holoTCII) (B12-TCII) were performed. After 3 months of metformin therapy, oral calcium supplementation was administered. Serial serum vitamin B12 determinations revealed a similar decline in vitamin B12 and holoTCII. Oral calcium supplementation reversed the metformin-induced serum holoTCII depression. Patients receiving metformin have diminished B12 absorption and low serum total vitamin B12 and TCII-B12 levels because of a calcium-dependent ileal membrane antagonism, an effect reversed with supplemental calcium. JF - Diabetes care AU - Bauman, W A AU - Shaw, S AU - Jayatilleke, E AU - Spungen, A M AU - Herbert, V AD - Department of Medicine, Mount Sinai School of Medicine, New York, USA. bauman.william@bronx.va.gov Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 1227 EP - 1231 VL - 23 IS - 9 SN - 0149-5992, 0149-5992 KW - Calcium, Dietary KW - 0 KW - Hypoglycemic Agents KW - Metformin KW - 9100L32L2N KW - Calcium Carbonate KW - H0G9379FGK KW - Vitamin B 12 KW - P6YC3EG204 KW - Index Medicus KW - Ethnic Groups KW - Humans KW - Adult KW - Middle Aged KW - Dietary Supplements KW - Male KW - Calcium Carbonate -- therapeutic use KW - Hypoglycemic Agents -- adverse effects KW - Metformin -- adverse effects KW - Vitamin B 12 -- blood KW - Intestinal Absorption -- drug effects KW - Calcium, Dietary -- therapeutic use KW - Vitamin B 12 -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72240307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+care&rft.atitle=Increased+intake+of+calcium+reverses+vitamin+B12+malabsorption+induced+by+metformin.&rft.au=Bauman%2C+W+A%3BShaw%2C+S%3BJayatilleke%2C+E%3BSpungen%2C+A+M%3BHerbert%2C+V&rft.aulast=Bauman&rft.aufirst=W&rft.date=2000-09-01&rft.volume=23&rft.issue=9&rft.spage=1227&rft.isbn=&rft.btitle=&rft.title=Diabetes+care&rft.issn=01495992&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-21 N1 - Date created - 2000-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Race, age, and back pain as factors in completion of residential substance abuse treatment by veterans. AN - 72239861; 10970920 AB - Variables associated with successful completion of residential substance abuse treatment were identified. The records of 340 veterans admitted to a 120-day substance abuse treatment program were retrospectively analyzed. The likelihood of successful treatment completion was calculated as a function of race, age, gender, psychiatric diagnosis, past suicide attempts, homelessness, legal history, childhood physical or sexual abuse, parental history of addiction, multiple substance dependence, medical problems, and the race of the therapist. Univariate analysis and logistic regression analysis were used to identify variables that were significant predictors of treatment completion. Overall, 66 percent of veterans completed the program. Eighty-two percent of the veterans admitted to the program were black, and 16 percent were white. The completion rate of black veterans (71 percent) was significantly higher than that of white veterans (49 percent). Veterans completing treatment were significantly more likely to be older, by an average of two years, than those who did not complete treatment. The association between younger age and failure to complete the program was largely accounted for by younger black veterans. Veterans with back pain were significantly less likely to complete treatment than those without back pain. Completion rates did not vary by the other variables examined. In the regression analysis that included age, race, and back pain, each variable, when adjusted by the other variables, was a significant predictor of completion. White patients were less likely to complete residential substance abuse treatment in a program in which the majority of both therapists and patients were black. Younger black veterans and those with back pain were also less likely to complete treatment. JF - Psychiatric services (Washington, D.C.) AU - Stack, K AU - Cortina, J AU - Samples, C AU - Zapata, M AU - Arcand, L F AD - Hampton VA Hospital, VA 23667, USA. stack@med.va.gov Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 1157 EP - 1161 VL - 51 IS - 9 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - Age Factors KW - Humans KW - Adult KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - African Americans -- psychology KW - European Continental Ancestry Group -- psychology KW - African Americans -- statistics & numerical data KW - Veterans -- psychology KW - European Continental Ancestry Group -- statistics & numerical data KW - Substance-Related Disorders -- rehabilitation KW - Back Pain -- therapy KW - Substance-Related Disorders -- epidemiology KW - Residential Treatment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72239861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Race%2C+age%2C+and+back+pain+as+factors+in+completion+of+residential+substance+abuse+treatment+by+veterans.&rft.au=Stack%2C+K%3BCortina%2C+J%3BSamples%2C+C%3BZapata%2C+M%3BArcand%2C+L+F&rft.aulast=Stack&rft.aufirst=K&rft.date=2000-09-01&rft.volume=51&rft.issue=9&rft.spage=1157&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-12 N1 - Date created - 2000-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Matching alcoholics to treatment. Failure to replicate finding of an earlier study. AN - 72217202; 10963930 AB - The purpose of the present study was to investigate whether sociopathic alcoholics respond differentially to different types of treatment. An earlier study found that alcoholics with antisocial personality disorder had somewhat better outcomes if treated in individually focused versus relationship-focused cognitive-behavioral treatment. The present study was designed to attempt to replicate these findings. One hundred and forty-nine alcoholics (42 of whom scored high on a measure of sociopathy) were randomly assigned to receive either individually focused cognitive-behavioral treatment or a relationship-focused community reinforcement approach. Follow-up evaluations were conducted every 4 months for 2 years. Results failed to support the study hypothesis. Drinking outcomes were similar for sociopathic alcoholics in both treatment conditions. Directions for future research are identified. JF - Journal of substance abuse treatment AU - Kalman, D AU - Longabaugh, R AU - Clifford, P R AU - Beattie, M AU - Maisto, S A AD - Center for Alcohol and Addiction Studies, Brown University, 02912, Providence, RI, USA. Kalman.David@bedford.va.gov Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 183 EP - 187 VL - 19 IS - 2 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Treatment Failure KW - Behavior Therapy KW - Humans KW - Reinforcement (Psychology) KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Alcoholism -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72217202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Matching+alcoholics+to+treatment.+Failure+to+replicate+finding+of+an+earlier+study.&rft.au=Kalman%2C+D%3BLongabaugh%2C+R%3BClifford%2C+P+R%3BBeattie%2C+M%3BMaisto%2C+S+A&rft.aulast=Kalman&rft.aufirst=D&rft.date=2000-09-01&rft.volume=19&rft.issue=2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-25 N1 - Date created - 2000-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of gastrin-releasing peptide and its receptor aberrantly expressed by human colon cancer cell lines. AN - 72203273; 10953054 AB - Gastrin-releasing peptide (GRP) is a mitogen and morphogen important in the development of human colon cancers. Although epithelial cells lining the colon do not normally express GRP or its receptor (GRP-R), most human tumors express GRP-R mRNA. Yet functional protein has only been detected in 24 to 40% of colon cancers. To elucidate the reason for the difference between the expression of GRP/GRP-R mRNA and protein, we studied nine human colon cancer cell lines. Quantitative polymerase chain reaction revealed that all colon cancer cell lines expressed similar amounts of mRNA for both GRP as well as GRP-R. Yet binding studies using (125)I-Tyr(4)-bombesin detected functional receptors on only five of the nine cell lines studied. Conformational fragment-length polymorphism analysis indicated that although mRNA for the ligand GRP was never mutated, mRNA for the GRP-R was always mutated. Sequencing revealed that the message for GRP-R contained between two and seven separate mutations at the nucleotide level. This resulted in 14 separate coding mutations, 2 of which were observed in more than one cell line. Each mutation was individually recreated by site-directed mutagenesis and studied in transiently transfected Chinese hamster ovary-K1 cells. Alteration of Pro(145) into a tyrosine, of Val(317) into a glutamic acid, and insertion of a 32-nucleotide segment resulting in a frameshift distal to Asp(137) all resulted in GRP receptors incapable of binding ligand. Thus, these data indicate that human colon cancers commonly express GRP and GRP-R mRNA but that receptor mutations account for the failure of functional protein to be generated. JF - Molecular pharmacology AU - Carroll, R E AU - Ostrovskiy, D AU - Lee, S AU - Danilkovich, A AU - Benya, R V AD - Department of Medicine, University of Illinois at Chicago and Chicago Veterans Administration Medical Center (West Side Division), Chicago, Illinois 60612, USA. Y1 - 2000/09// PY - 2000 DA - September 2000 SP - 601 EP - 607 VL - 58 IS - 3 SN - 0026-895X, 0026-895X KW - RNA, Messenger KW - 0 KW - Receptors, Bombesin KW - Gastrin-Releasing Peptide KW - 80043-53-4 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - Tumor Cells, Cultured KW - Transfection KW - Humans KW - Molecular Sequence Data KW - CHO Cells KW - Caco-2 Cells KW - Amino Acid Sequence KW - RNA, Messenger -- biosynthesis KW - Protein Conformation KW - Cricetinae KW - Binding Sites KW - Receptors, Bombesin -- genetics KW - Gastrin-Releasing Peptide -- genetics KW - Gastrin-Releasing Peptide -- biosynthesis KW - Colonic Neoplasms -- metabolism KW - Receptors, Bombesin -- biosynthesis KW - Receptors, Bombesin -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72203273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Characterization+of+gastrin-releasing+peptide+and+its+receptor+aberrantly+expressed+by+human+colon+cancer+cell+lines.&rft.au=Carroll%2C+R+E%3BOstrovskiy%2C+D%3BLee%2C+S%3BDanilkovich%2C+A%3BBenya%2C+R+V&rft.aulast=Carroll&rft.aufirst=R&rft.date=2000-09-01&rft.volume=58&rft.issue=3&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-25 N1 - Date created - 2000-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Latex allergy and the healthcare worker. AN - 70529440; 11854963 AB - The purpose of this article is to describe the clinical manifestations and treatment of latex allergy. A discussion of the identification of latex-sensitized staff and available diagnostic tests is presented. Emphasis is placed on the healthcare worker's role in preventing future latex allergy cases from developing. JF - Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates AU - Wai, D M AD - VA Connecticut Healthcare System, 874 Hill Street, Hamden, CT 06514, USA. wai.donna_e@west-haven.va.gov PY - 2000 SP - 226 EP - 231 VL - 23 IS - 5 SN - 1042-895X, 1042-895X KW - Nursing KW - Radioallergosorbent Test KW - Occupational Health KW - Information Services KW - Nursing Assessment KW - Skin Tests KW - Risk Factors KW - Humans KW - Primary Prevention -- methods KW - Internet KW - Risk Assessment KW - Latex Hypersensitivity -- etiology KW - Occupational Diseases -- diagnosis KW - Occupational Exposure -- statistics & numerical data KW - Latex Hypersensitivity -- epidemiology KW - Occupational Diseases -- etiology KW - Latex Hypersensitivity -- diagnosis KW - Latex Hypersensitivity -- therapy KW - Occupational Exposure -- prevention & control KW - Health Personnel KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- therapy KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70529440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology+nursing+%3A+the+official+journal+of+the+Society+of+Gastroenterology+Nurses+and+Associates&rft.atitle=Latex+allergy+and+the+healthcare+worker.&rft.au=Wai%2C+D+M&rft.aulast=Wai&rft.aufirst=D&rft.date=2000-09-01&rft.volume=23&rft.issue=5&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Gastroenterology+nursing+%3A+the+official+journal+of+the+Society+of+Gastroenterology+Nurses+and+Associates&rft.issn=1042895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-14 N1 - Date created - 2002-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CLIC-1 Functions as a Chloride Channel When Expressed and Purified from Bacteria AN - 17689484; 4781383 AB - CLIC-1 is a member of a family of proteins related to the bovine intracellular chloride channel p64 which has been proposed to function as a chloride channel. We expressed CLIC-1 as a glutathione S-transferase fusion protein in bacteria. The fusion protein was purified by glutathione affinity, and CLIC-1 was released from its fusion partner by digestion with thrombin. After further purification, CLIC-1 was reconstituted into phospholipid vesicles by detergent dialysis. Chloride permeability of reconstituted vesicles was assessed using a valinomycin dependent chloride efflux assay, demonstrating increased vesicular chloride permeability with CLIC-1 compared with control. CLIC-1-dependent chloride permeability was inhibited by indanyloxyacetic acid-94 with an apparent IC sub(50) of 8.6 mu M. The single channel properties of CLIC-1 were determined using the planar lipid bilayer technique. We found that CLIC-1 forms a voltage-dependent, Cl-selective channel with a rectifying current-voltage relationship and single channel conductances of 161 plus or minus 7.9 and 67.5 plus or minus 6.9 picosiemens in symmetric 300 and 150 mM KCl, respectively. The anion selectivity of this activity is Br approximately Cl > I. The open probability of CLIC-1 channels in planar bilayers was decreased by indanyloxyacetic acid-94 with an apparent IC sub(50) of 86 mu M at 50 mV. These data convincingly demonstrate that CLIC-1 is capable of forming a novel, chloride-selective channel in the absence of other subunits or proteins. JF - Journal of Biological Chemistry AU - Tulk, B M AU - Schlesinger, PH AU - Kapadia, SA AU - Edwards, J C AD - Department of Internal Medicine, St. Louis University, USA, John.Edwards3@med.va.gov Y1 - 2000/09/01/ PY - 2000 DA - 2000 Sep 01 SP - 26986 EP - 26993 VL - 275 IS - 35 SN - 0021-9258, 0021-9258 KW - in vitro KW - CLIC-1 protein KW - chloride channels KW - p64 protein KW - Microbiology Abstracts B: Bacteriology KW - Membrane vesicles KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17689484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=CLIC-1+Functions+as+a+Chloride+Channel+When+Expressed+and+Purified+from+Bacteria&rft.au=Tulk%2C+B+M%3BSchlesinger%2C+PH%3BKapadia%2C+SA%3BEdwards%2C+J+C&rft.aulast=Tulk&rft.aufirst=B&rft.date=2000-09-01&rft.volume=275&rft.issue=35&rft.spage=26986&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Membrane vesicles ER - TY - JOUR T1 - Galanin-1 receptor up-regulation mediates the excess colonic fluid production caused by infection with enteric pathogens AN - 17689413; 4773712 AB - Galanin is widely distributed in enteric nerve terminals lining the gastrointestinal tract. We previously showed that pathogenic Escherichia coli, but not normal commensal organisms, increase galanin-1 receptor expression by epithelial cells lining the colon (i.e., colonocytes). When present, galanin-1 receptor activation by ligand causes colonocyte Cl super(-) secretion. We herein demonstrate that disparate pathogens including Salmonella typhimurium and Shigella flexerii also increase colonocyte galanin-1 receptor expression, whose activation is responsible for a principal component of the increased colonic fluid secretion observed. Although eliminating the GAL1R gene by homologous recombination does not alter basal colonic fluid secretion, removal of one or both alleles completely attenuates the increase in fluid secretion due to infection with enteric pathogens. Galanin-1 receptor up-regulation therefore represents a novel mechanism accounting for the increased colonic fluid secretion observed in infectious diarrhea due to several different pathogens. JF - Nature Medicine AU - Matkowskyj, KA AU - Danilkovich, A AU - Marrero, J AU - Savkovic, S D AU - Hecht, G AU - Benya, R V AD - Departments of Medicine, University of Illinois at Chicago and Chicago Veterans Administration Medical Center (West Side Division), Chicago, Illinois 60612, USA, rvbenya@uic.edu Y1 - 2000/09// PY - 2000 DA - Sep 2000 SP - 1048 EP - 1051 VL - 6 IS - 9 SN - 1078-8956, 1078-8956 KW - Microbiology Abstracts B: Bacteriology KW - Galanin KW - Diarrhea KW - Nerve endings KW - Shigellosis KW - Salmonellosis KW - Shigella flexneri KW - Escherichia coli KW - Galanin receptors KW - Gastrointestinal tract KW - Salmonella typhimurium KW - J 02846:Gastrointestinal tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17689413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Galanin-1+receptor+up-regulation+mediates+the+excess+colonic+fluid+production+caused+by+infection+with+enteric+pathogens&rft.au=Matkowskyj%2C+KA%3BDanilkovich%2C+A%3BMarrero%2C+J%3BSavkovic%2C+S+D%3BHecht%2C+G%3BBenya%2C+R+V&rft.aulast=Matkowskyj&rft.aufirst=KA&rft.date=2000-09-01&rft.volume=6&rft.issue=9&rft.spage=1048&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Salmonella typhimurium; Shigella flexneri; Salmonellosis; Shigellosis; Gastrointestinal tract; Nerve endings; Galanin; Diarrhea; Galanin receptors ER - TY - JOUR T1 - NAC-1 is a brain POZ/BTB protein that can prevent cocaine-induced sensitization in the rat. AN - 71761317; 10934270 AB - Levels of the mRNA NAC-1 are increased in the rat forebrain weeks after cocaine exposure. This long-term neuroadaptation occurs during the expression of behavioral sensitization, a model of psychostimulant-induced paranoia. NAC-1, the protein encoded by this cocaine-regulated mRNA, contains a Pox virus and zinc finger/bric-a-brac tramtrack broad complex (POZ/BTB) motif, which mediates interactions among several transcriptional regulators. The present studies demonstrate that NAC-1 acts as a transcription factor. NAC-1 was localized to the nucleus of neurons in the brain. Transfection of NAC-1 in cell culture repressed transcription of a reporter gene. NAC-1 was also able to affect the actions of other POZ/BTB proteins in mammalian two-hybrid studies; these interactions required the presence of the POZ/BTB domain. However, NAC-1 appears to be a unique POZ/BTB transcriptional regulator because it does not contain any zinc finger regions found in these other DNA-binding proteins. Adenoviral-mediated overexpression of NAC-1 protein in the rat nucleus accumbens prevented the development but not the expression of behavioral sensitization produced by repeated administration of cocaine. Thus, NAC-1 may modify the long-term behaviors of psychostimulant abuse by regulating gene transcription in the mammalian brain. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Mackler, S A AU - Korutla, L AU - Cha, X Y AU - Koebbe, M J AU - Fournier, K M AU - Bowers, M S AU - Kalivas, P W AD - Departments of Medicine and Psychiatry, Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania 19104, USA. smackler@mail.med.upenn.edu Y1 - 2000/08/15/ PY - 2000 DA - 2000 Aug 15 SP - 6210 EP - 6217 VL - 20 IS - 16 SN - 0270-6474, 0270-6474 KW - ABTB1 protein, human KW - 0 KW - Nacc1 protein, rat KW - Nerve Tissue Proteins KW - Repressor Proteins KW - Transcription Factors KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Nucleus Accumbens -- drug effects KW - Cocaine-Related Disorders -- physiopathology KW - Protein Structure, Tertiary -- physiology KW - Nucleus Accumbens -- metabolism KW - Nucleus Accumbens -- physiopathology KW - Cocaine-Related Disorders -- metabolism KW - Male KW - Binding Sites -- physiology KW - Transcription, Genetic -- physiology KW - Brain -- physiopathology KW - Brain -- drug effects KW - Repressor Proteins -- metabolism KW - Nerve Tissue Proteins -- metabolism KW - Cocaine -- toxicity KW - Brain -- metabolism KW - Nerve Tissue Proteins -- genetics KW - Repressor Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71761317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=NAC-1+is+a+brain+POZ%2FBTB+protein+that+can+prevent+cocaine-induced+sensitization+in+the+rat.&rft.au=Mackler%2C+S+A%3BKorutla%2C+L%3BCha%2C+X+Y%3BKoebbe%2C+M+J%3BFournier%2C+K+M%3BBowers%2C+M+S%3BKalivas%2C+P+W&rft.aulast=Mackler&rft.aufirst=S&rft.date=2000-08-15&rft.volume=20&rft.issue=16&rft.spage=6210&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-31 N1 - Date created - 2000-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment of an edentulous patient with a dry mouth. AN - 70549739; 12167886 AB - Dental health professionals are being asked to care for a growing number and range of medically compromised patients living with chronic health problems. Although tooth loss overall has declined in the United States, millions of persons, particularly those of more advanced age, still require treatment for the edentulous condition. Particular challenges are faced when this oral state is combined with a complex medical history. The primary learning objective for this case is to increase your general knowledge of and skills in the dental management of the complete denture patient with a dry mouth. JF - The journal of contemporary dental practice AU - Shay, K AD - VA Health Services of lower Michigan, USA. Ken.Shay@med.va.gov Y1 - 2000/08/15/ PY - 2000 DA - 2000 Aug 15 SP - 98 VL - 1 IS - 3 KW - Adhesives KW - 0 KW - Anti-Inflammatory Agents KW - Anti-Inflammatory Agents, Non-Steroidal KW - Antirheumatic Agents KW - Salicylates KW - salicylsalicylic acid KW - V9MO595C9I KW - Prednisone KW - VB0R961HZT KW - Methotrexate KW - YL5FZ2Y5U1 KW - Dentistry KW - Index Medicus KW - Prednisone -- pharmacology KW - Drug Interactions KW - Methotrexate -- pharmacology KW - Humans KW - Aged KW - Antirheumatic Agents -- pharmacology KW - Salicylates -- pharmacology KW - Patient Education as Topic KW - Denture, Complete KW - Denture Retention KW - Male KW - Anti-Inflammatory Agents -- pharmacology KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology KW - Arthritis, Rheumatoid -- complications KW - Xerostomia -- complications KW - Mouth, Edentulous -- therapy KW - Mouth, Edentulous -- complications KW - Dental Care for Chronically Ill UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70549739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+contemporary+dental+practice&rft.atitle=Treatment+of+an+edentulous+patient+with+a+dry+mouth.&rft.au=Shay%2C+K&rft.aulast=Shay&rft.aufirst=K&rft.date=2000-08-15&rft.volume=1&rft.issue=3&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=The+journal+of+contemporary+dental+practice&rft.issn=1526-3711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-08-21 N1 - Date created - 2002-08-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of cholera toxin on rat liver lysosome acidification. AN - 71264919; 10924342 AB - We have shown that cholera toxin and cAMP greatly increase both acidification rates of liver endosomes and the liver and endosome content of fluid-phase endocytosis probes. In this study lysosomes were purified from control and cholera toxin-treated livers that were pulsed with fluorescein conjugated dextran and chased overnight. Cholera toxin-treated livers weighed less, contained less protein and exhibited higher contents of lysosomal marker enzymes, consistent with the catabolic effects of this agent. By contrast to its effects on endosomes, cholera toxin had no consistent or significant effect on lysosome acidification rates, steady-state internal pH or potassium content, proton leak rates or fluorescein-dextran content. We conclude that cholera toxin and cAMP predominantly alter earlier steps of endocytosis but may also increase transfer of probes from lysosomes to bile. Copyright 2000 Academic Press. JF - Biochemical and biophysical research communications AU - Van Dyke, R W AU - Ervin, L L AU - Lewis, M R AU - Wang, X AD - Department of Medicine, University of Michigan Medical School and Veterans' Administration Hospital, Ann Arbor, Michigan, 48109-0682, USA. Y1 - 2000/08/11/ PY - 2000 DA - 2000 Aug 11 SP - 717 EP - 721 VL - 274 IS - 3 SN - 0006-291X, 0006-291X KW - Adjuvants, Immunologic KW - 0 KW - Cholera Toxin KW - 9012-63-9 KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Ion Transport -- drug effects KW - Cyclic AMP -- pharmacology KW - Endocytosis -- drug effects KW - Male KW - Liver -- ultrastructure KW - Liver -- drug effects KW - Cholera Toxin -- pharmacology KW - Liver -- metabolism KW - Lysosomes -- metabolism KW - Lysosomes -- drug effects KW - Adjuvants, Immunologic -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71264919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Effect+of+cholera+toxin+on+rat+liver+lysosome+acidification.&rft.au=Van+Dyke%2C+R+W%3BErvin%2C+L+L%3BLewis%2C+M+R%3BWang%2C+X&rft.aulast=Van+Dyke&rft.aufirst=R&rft.date=2000-08-11&rft.volume=274&rft.issue=3&rft.spage=717&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-15 N1 - Date created - 2000-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Elderly Norms for the Hopkins Verbal Learning Test-Revised AN - 85534596; 200113503 AB - The present study evaluates the effects of age, education, & gender in a representative sample of older adults & provides normative data for community-dwelling elderly. Age & gender had significant effects on HVLT-R performance. We provide age- & gender-adjusted normative data. Surprisingly, education level did not affect HVLT-R performance, indicating that education-adjusted norms are not necessary for this measure within this age range. We evaluated a subsample of subjects census-matched on age, education, & gender. These subjects did not differ in overall performance from our entire sample. Therefore, the normative data provided in this paper can be considered to be census-comparable for age, education, & gender. Adapted from the source document JF - The Clinical Neuropsychologist AU - Vanderploeg, Rodney D AU - Schinka, John A AU - Jones, Tatyana AU - Small, Brent J AU - Graves, Amy Borenstein AU - Mortimer, James A AD - Psychology Service, James A. Haley Veterans Hospital, Tampa, FL Rodney.Vanderploeg@med.va.gov Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 318 EP - 324 VL - 14 IS - 3 SN - 1385-4046, 1385-4046 KW - Elderly (21350) KW - Psychometric Analysis (69210) KW - Age Differences (01150) KW - Verbal Learning (93750) KW - Sex Differences (77850) KW - Academic Achievement (00070) KW - Test Validity and Reliability (88800) KW - article KW - 6910: psychometrics; psychometrics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85534596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Clinical+Neuropsychologist&rft.atitle=Elderly+Norms+for+the+Hopkins+Verbal+Learning+Test-Revised&rft.au=Vanderploeg%2C+Rodney+D%3BSchinka%2C+John+A%3BJones%2C+Tatyana%3BSmall%2C+Brent+J%3BGraves%2C+Amy+Borenstein%3BMortimer%2C+James+A&rft.aulast=Vanderploeg&rft.aufirst=Rodney&rft.date=2000-08-01&rft.volume=14&rft.issue=3&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=The+Clinical+Neuropsychologist&rft.issn=13854046&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CLNEEC N1 - SubjectsTermNotLitGenreText - Psychometric Analysis (69210); Verbal Learning (93750); Test Validity and Reliability (88800); Sex Differences (77850); Age Differences (01150); Elderly (21350); Academic Achievement (00070) ER - TY - JOUR T1 - Long-term follow-up of Barrett's high-grade dysplasia. AN - 85356663; pmid-10950031 AB - OBJECTIVE: The management of Barrett's high-grade dysplasia (HGD) remains controversial. The aims of this study were to evaluate prospectively the outcome of unifocal HGD (uHGD) in patients with Barrett's esophagus, and to determine demographic and endoscopic features predictive of progression to multifocal HGD (mHGD) and/or adenocarcinoma. METHODS: Consecutive Barrett's patients in whom uHGD was found at initial endoscopy or during surveillance underwent intensification of medical treatment and repeat endoscopy. The study endpoint was progression to mHGD or adenocarcinoma or HGD in conjunction with a dysplasia-associated lesion or mass (DALM). HGD diagnosis was confirmed by a second, blinded pathologist. RESULTS: A total of 15 Barrett's patients with uHGD met inclusion criteria and have been prospectively followed for a mean +/- SD of 36.8 +/- 23.2 months. All were white and male, with a mean age +/- SD of 61.4 +/- 14.9 yr. Barrett's length varied from 1 to 13 cm (mean, +/- SD, 6.8 +/- 4 cm). Overall, eight (53.3%) uHGD progressed: four of 15 (26.7%) to frank cancer between 17 and 35 months of follow-up, two of 15 (13.3%) to mHGD with DALM in conjunction with one or more foci of possible intramucosal cancer after 12-91 months of follow-up, one of 15 (6.7%) to mHGD with a focus of possible intramucosal cancer after 14 months, and one of 15 (6.7%) to mHGD after 29 months. Seven of 15 (46.7%) uHGD have regressed, five to no dysplasia and two to LGD, over the course of follow-up ranging from 24 to 73 months (mean +/- SD, 43.3 +/- 19.9). All three patients with short-segment Barrett's esophagus with uHGD regressed. Fisher's exact test revealed that Barrett's length > or =3 cm and presence of hiatal hernia approached significance (p < 0.08) in predicting uHGD progression to mHGD/DALM/cancer. However, use of the log-rank test to account for differences in length of follow-up show no significance for hiatal hernia or Barrett's length. CONCLUSIONS: Barrett's uHGD has a high risk for progressing to mHGD or cancer. Justification of an observational approach to uHGD should be discouraged. Markers of uHGD progression, as well as regression, are needed. JF - The American journal of gastroenterology AU - Weston, A P AU - Sharma, P AU - Topalovski, M AU - Richards, R AU - Cherian, R AU - Dixon, A AD - Veterans Administration Medical Center, Kansas City, Missouri 64128, USA. Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 1888 EP - 1893 VL - 95 IS - 8 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Prospective Studies KW - Single-Blind Method KW - Humans KW - Adult KW - Disease Progression KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Longitudinal Studies KW - Male KW - Adenocarcinoma -- pathology KW - Esophageal Neoplasms -- pathology KW - Esophagus -- pathology KW - Barrett Esophagus -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85356663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Long-term+follow-up+of+Barrett%27s+high-grade+dysplasia.&rft.au=Weston%2C+A+P%3BSharma%2C+P%3BTopalovski%2C+M%3BRichards%2C+R%3BCherian%2C+R%3BDixon%2C+A&rft.aulast=Weston&rft.aufirst=A&rft.date=2000-08-01&rft.volume=95&rft.issue=8&rft.spage=1888&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Gulf War illness research: separating the wheat from the chaff. AN - 72601651; 11262710 AB - Clinical research of veterans' illnesses from the neuropsychology and medical literature are reviewed. Some studies reveal no significant findings, while others indeed detect a higher incidence of clinical and laboratory abnormalities in veterans of Operations Desert Storm and Desert Shield. Neuropsychological deficits are negligible and more often associated with affective, than cognitive, disruption. Some explanations of the results are offered, as are recommendations regarding the utility of clinical research. JF - The Clinical neuropsychologist AU - Axelrod, B N AU - Milner, I B AD - John D. Dingell Department of Veterans Affairs Medical Center, Detroit, MI, USA. bradley.axelrod@med.va.gov Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 344 EP - 348 VL - 14 IS - 3 SN - 1385-4046, 1385-4046 KW - Index Medicus KW - Humans KW - Veterans -- psychology KW - Neuropsychological Tests KW - Cognition Disorders -- etiology KW - Cognition Disorders -- diagnosis KW - Persian Gulf Syndrome -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72601651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Clinical+neuropsychologist&rft.atitle=Gulf+War+illness+research%3A+separating+the+wheat+from+the+chaff.&rft.au=Axelrod%2C+B+N%3BMilner%2C+I+B&rft.aulast=Axelrod&rft.aufirst=B&rft.date=2000-08-01&rft.volume=14&rft.issue=3&rft.spage=344&rft.isbn=&rft.btitle=&rft.title=The+Clinical+neuropsychologist&rft.issn=13854046&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-12 N1 - Date created - 2001-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enteropathogenic Escherichia coli dephosphorylates and dissociates occludin from intestinal epithelial tight junctions. AN - 72562038; 11207587 AB - Enteropathogenic Escherichia coli (EPEC) increases tight junction permeability in part by phosphorylating the 20 kDa myosin light chain (MLC20) that induces cytoskeletal contraction. The impact of this enteric pathogen on specific tight junction (TJ) proteins has not been investigated. We examined the effect of EPEC infection on occludin localization and phosphorylation in intestinal epithelial cells. After infection by EPEC, a progressive shift of occludin from a primarily TJ-associated domain to an intracellular compartment occurred, as demonstrated by immunofluorescent staining. A reverse in the ratio of phosphorylated to dephosphorylated occludin accompanied this morphological change. Eradication of EPEC with gentamicin resulted in the normalization of occludin localization and phosphorylation. The serine/threonine phosphatase inhibitor, calyculin A, prevented these events. The EPEC-associated decrease in transepithelial electrical resistance, a measure of TJ barrier function, returned to baseline after gentamicin treatment. Non-pathogenic E. coli, K-12, did not induce these changes. Transformation of K-12 with the pathogenicity island of EPEC, however, conferred the phenotype of wild-type EPEC. Deletion of specific EPEC genes encoding proteins involved in EPEC type III secretion markedly attenuated these effects. These findings suggest that EPEC-induced alterations in occludin contribute to the pathophysiology associated with this infection. JF - Cellular microbiology AU - Simonovic, I AU - Rosenberg, J AU - Koutsouris, A AU - Hecht, G AD - Department of Medicine, University of Illinois and West Side Department of Veterans Administration Medical Center, Chicago, IL 60612, USA. Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 305 EP - 315 VL - 2 IS - 4 SN - 1462-5814, 1462-5814 KW - Anti-Bacterial Agents KW - 0 KW - Bacterial Proteins KW - Gentamicins KW - Membrane Proteins KW - OCLN protein, human KW - Occludin KW - Oxazoles KW - calyculin A KW - 7D07U14TK3 KW - Index Medicus KW - Immunoblotting KW - Transformation, Bacterial KW - Bacterial Proteins -- genetics KW - Humans KW - Anti-Bacterial Agents -- pharmacology KW - Tight Junctions -- drug effects KW - Gene Deletion KW - Virulence KW - Tumor Cells, Cultured KW - Oxazoles -- pharmacology KW - Phosphorylation KW - Time Factors KW - Fluorescent Antibody Technique KW - Gentamicins -- pharmacology KW - Tight Junctions -- metabolism KW - Membrane Proteins -- metabolism KW - Escherichia coli -- pathogenicity KW - Intestinal Mucosa -- microbiology KW - Intestinal Mucosa -- metabolism KW - Intestinal Mucosa -- drug effects KW - Escherichia coli -- genetics KW - Membrane Proteins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72562038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+microbiology&rft.atitle=Enteropathogenic+Escherichia+coli+dephosphorylates+and+dissociates+occludin+from+intestinal+epithelial+tight+junctions.&rft.au=Simonovic%2C+I%3BRosenberg%2C+J%3BKoutsouris%2C+A%3BHecht%2C+G&rft.aulast=Simonovic&rft.aufirst=I&rft.date=2000-08-01&rft.volume=2&rft.issue=4&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Cellular+microbiology&rft.issn=14625814&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-15 N1 - Date created - 2001-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Leukocytoclastic vasculitis due to etanercept. AN - 72202869; 10955351 AB - Recently etanercept, a soluble recombinant tumor necrosis factor receptor:Fc fusion protein, became available to treat patients with rheumatoid arthritis (RA). Among adverse reactions are cutaneous side effects, which occur in about 5% of patients. These have included mostly injection site reactions as well as urticarial reactions. We describe the first case of leukocytoclastic vasculitis associated with the use of etanercept in a patient with severe, deforming RA previously unresponsive to multiple therapies. Discontinuation of the drug led to complete resolution of the vasculitis. JF - The Journal of rheumatology AU - Galaria, N A AU - Werth, V P AU - Schumacher, H R AD - Department of Dermatology, Hospital of the University of Pennsylvania, and the Veterans Administration Hospital, Philadelphia, USA. Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 2041 EP - 2044 VL - 27 IS - 8 SN - 0315-162X, 0315-162X KW - Antirheumatic Agents KW - 0 KW - Immunoglobulin G KW - Receptors, Tumor Necrosis Factor KW - Recombinant Proteins KW - Etanercept KW - OP401G7OJC KW - Index Medicus KW - Fluorescent Antibody Technique, Direct KW - Humans KW - Middle Aged KW - Male KW - Vasculitis, Leukocytoclastic, Cutaneous -- chemically induced KW - Arthritis, Rheumatoid -- drug therapy KW - Immunoglobulin G -- adverse effects KW - Antirheumatic Agents -- adverse effects KW - Recombinant Proteins -- adverse effects KW - Vasculitis, Leukocytoclastic, Cutaneous -- pathology KW - Arthritis, Rheumatoid -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72202869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+rheumatology&rft.atitle=Leukocytoclastic+vasculitis+due+to+etanercept.&rft.au=Galaria%2C+N+A%3BWerth%2C+V+P%3BSchumacher%2C+H+R&rft.aulast=Galaria&rft.aufirst=N&rft.date=2000-08-01&rft.volume=27&rft.issue=8&rft.spage=2041&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+rheumatology&rft.issn=0315162X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-14 N1 - Date created - 2000-11-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sodium-sensitive hypertension is not associated with higher sympathetic nervous system activity in older hypertensive humans. AN - 71752768; 10950395 AB - The majority of older hypertensive humans are sodium sensitive and they are characterized by increased alpha-adrenergic responsiveness relative to their level of sympathetic nervous system (SNS) activity. To test the hypothesis that heightened SNS activity and/or increased alpha-adrenergic receptor responsiveness during sodium loading may play a role in the sodium-dependent increase in blood pressure in older sodium-sensitive hypertensives, we used compartmental analysis of [3H]norepinephrine (NE) kinetics to determine the release rate of NE into an extravascular compartment (NE2) as an index of systemic SNS activity and determined forearm blood flow responses to graded intrabrachial artery NE and angiotensin II (ANG II) infusions and platelet membrane alpha2-receptor properties in 24 older (age 64 +/- 7 years) hypertensive subjects. Subjects were studied at the end of 1 week of a low (20 mmol/day)- and again at the end of 1 week of a high (200 mmol/day)-sodium diet. Subjects were categorized as sodium sensitive (SS) if they had a > or = 5 mm Hg increase in mean arterial blood pressure (MABP) with dietary sodium loading (n = 16), or sodium-resistant (SR) if their MABP increased by < 5 mm Hg (n = 8). Neither dietary sodium intake nor sodium-sensitivity status significantly affected arterial plasma NE levels, NE2, or other NE kinetic parameters. Forearm blood flow responses to NE or to ANG II, and platelet alpha2-receptor properties were similar between the SS and SR groups. These results suggest that the sodium-dependent increase in MABP that characterizes SS hypertension among older humans is not because of an increase in systemic SNS activity or increased arterial adrenergic receptor responsiveness. JF - American journal of hypertension AU - Brown, M D AU - Hogikyan, R V AU - Dengel, D R AU - Supiano, M A AD - Department of Internal Medicine, University of Michigan Health System and GRECC, Ann Arbor Veterans Administration Health System, USA. mb166@umail.umd.edu Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 873 EP - 883 VL - 13 IS - 8 SN - 0895-7061, 0895-7061 KW - Sodium Chloride, Dietary KW - 0 KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Norepinephrine KW - X4W3ENH1CV KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - Age Factors KW - Norepinephrine -- blood KW - Humans KW - Blood Platelets -- enzymology KW - Adenylyl Cyclases -- metabolism KW - Middle Aged KW - Epinephrine -- blood KW - Regional Blood Flow KW - Male KW - Female KW - Sodium Chloride, Dietary -- adverse effects KW - Hypertension -- physiopathology KW - Sympathetic Nervous System -- physiopathology KW - Sodium Chloride, Dietary -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71752768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hypertension&rft.atitle=Sodium-sensitive+hypertension+is+not+associated+with+higher+sympathetic+nervous+system+activity+in+older+hypertensive+humans.&rft.au=Brown%2C+M+D%3BHogikyan%2C+R+V%3BDengel%2C+D+R%3BSupiano%2C+M+A&rft.aulast=Brown&rft.aufirst=M&rft.date=2000-08-01&rft.volume=13&rft.issue=8&rft.spage=873&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hypertension&rft.issn=08957061&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-02 N1 - Date created - 2001-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Is succinylcholine after pretreatment with d-tubocurarine and lidocaine contraindicated for outpatient anesthesia? AN - 71255751; 10910840 AB - Because succinylcholine has obvious advantages for facilitating endotracheal intubation in the ambulatory setting (e.g., low cost, fast onset, and no need for reversal of neuromuscular block), it is important to determine whether this muscle relaxant is indeed associated with an increased incidence of postoperative myalgias, compared with alternative but more expensive nondepolarizing muscle relaxants. We studied 119 outpatients undergoing endoscopic nasal sinus surgery or septoplasty. The anesthetic technique consisted of propofol/lidocaine for induction, followed by isoflurane/nitrous oxide/oxygen for maintenance. Oral tracheal intubation was performed by using a fiberscope. Patients were randomly assigned to one of two muscle relaxant groups. Group 1 patients received d-tubocurarine 3 mg followed by succinylcholine 1.5 mg/kg. Group 2 patients received mivacurium 0.2 mg/kg. After recovery from anesthesia, patients were asked whether they had any muscle pain and/or stiffness. Pain was categorized by location and quantified by using a verbal scale (from 0 to 10). Analgesic usage and myalgias limiting ambulation were recorded. After discharge from the ambulatory surgery unit, patients were contacted by telephone on Postoperative Day 1. If patients complained of myalgias, they were contacted by telephone on Days 2 and 3. Only one patient (in the mivacurium-treated group) reported myalgia as a limiting factor in ambulation or resumption of normal activity. There were no differences between groups with respect to the incidence (21% in the succinylcholine-treated group and 18% in the mivacurium-treated group), location, or severity of myalgia. In conclusion, succinylcholine (preceded by pretreatment with d-tubocurarine and lidocaine) is not associated with an increased incidence of myalgias, compared with mivacurium, when used to facilitate tracheal intubation in patients undergoing ambulatory nasal surgery. The results of this study show that the frequency of muscle pains after surgery in outpatients is approximately 20%, regardless of whether succinylcholine (after precurarization) or mivacurium is used to assist in insertion of the breathing tube. JF - Anesthesia and analgesia AU - Mikat-Stevens, M AU - Sukhani, R AU - Pappas, A L AU - Fluder, E AU - Kleinman, B AU - Stevens, R A AD - Department of Anesthesiology, Edward Hines Veterans Administration Hospital, Hines, USA. Y1 - 2000/08// PY - 2000 DA - August 2000 SP - 312 EP - 316 VL - 91 IS - 2 SN - 0003-2999, 0003-2999 KW - Anesthetics, Local KW - 0 KW - Isoquinolines KW - Neuromuscular Depolarizing Agents KW - Neuromuscular Nondepolarizing Agents KW - mivacurium KW - 77D66S9Q93 KW - Lidocaine KW - 98PI200987 KW - Succinylcholine KW - J2R869A8YF KW - Tubocurarine KW - W9YXS298BM KW - Abridged Index Medicus KW - Index Medicus KW - Anesthesia Recovery Period KW - Humans KW - Intubation, Intratracheal KW - Adult KW - Surveys and Questionnaires KW - Isoquinolines -- administration & dosage KW - Paranasal Sinuses -- surgery KW - Male KW - Female KW - Lidocaine -- administration & dosage KW - Muscular Diseases -- drug therapy KW - Neuromuscular Depolarizing Agents -- adverse effects KW - Ambulatory Surgical Procedures KW - Succinylcholine -- administration & dosage KW - Neuromuscular Nondepolarizing Agents -- administration & dosage KW - Succinylcholine -- contraindications KW - Succinylcholine -- adverse effects KW - Neuromuscular Depolarizing Agents -- contraindications KW - Tubocurarine -- administration & dosage KW - Anesthetics, Local -- administration & dosage KW - Muscular Diseases -- chemically induced KW - Pain, Postoperative -- drug therapy KW - Neuromuscular Depolarizing Agents -- administration & dosage KW - Pain, Postoperative -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71255751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Is+succinylcholine+after+pretreatment+with+d-tubocurarine+and+lidocaine+contraindicated+for+outpatient+anesthesia%3F&rft.au=Mikat-Stevens%2C+M%3BSukhani%2C+R%3BPappas%2C+A+L%3BFluder%2C+E%3BKleinman%2C+B%3BStevens%2C+R+A&rft.aulast=Mikat-Stevens&rft.aufirst=M&rft.date=2000-08-01&rft.volume=91&rft.issue=2&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=00032999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-15 N1 - Date created - 2000-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Variable Absorption of Carbidopa Affects Both Peripheral and Central Levodopa Metabolism AN - 21195817; 11643636 AB - Carbidopa (CD), a competitive inhibitor of aromatic l-amino acid decarboxylase that does not cross the blood-brain barrier, is routinely administered with levodopa (LD) to patients with Parkinson disease (PD) to reduce the peripheral decarboxylation of LD to dopamine. Using a stable isotope-labeled form of LD, the authors examined in 9 PD patients the effects of variable CD absorption on peripheral and central LD metabolism. Subjects were administered orally 50 mg of CD followed in 1 hour by a slow bolus intravenous infusion of 150 mg stable isotope-labeled LD (ring 1',2',3',4',5',6'- super(13)C). Eight patients underwent a lumbar puncture 6 hours following the infusion. Blood and cerebrospinal fluid (CSF) samples were analyzed for labeled and unlabeled metabolites using a combination of high-performance liquid chromatography and mass spectrometry. When patients were divided into 'slow' and 'rapid' CD absorption groups, significantly greater peripheral LD decarboxylation (as measured by area under the curve [AUC]-labeled serum HVA) was noted in the poor absorbers (p = 0.05, Mann-Whitney U test). Elimination half-lives for serum LD did not differ between groups, suggesting a further capacity for decarboxylation inhibition in the 'rapid' absorbers. A significant correlation between AUC serum CD and percent-labeled HVA in CSF was found for all patients (R = 0.786, p = 0.02). 'Rapid' as compared to 'slow' CD absorbers had significantly more percent-labeled CSF HVA (60 vs. 49, p = 0.02, Mann-Whitney U test), indicating greater central-labeled DA production in the better CD absorbers. The data suggest that peripheral aromatic l-amino acid decarboxylase activity is not saturated at CD doses used in current practice. The authors believe that future studies to better examine a dose dependence of CD on peripheral LD decarboxylation and LD brain uptake are warranted. JF - Journal of Clinical Pharmacology AU - Durso, R AU - Evans, JE AU - Josephs, E AU - Szabo, G AU - Evans, B AU - Fernandez, H H AU - Browne, T R AD - Departments of Neurology, Boston Veterans Administration Med ical Center and Boston University School of Medicine, Boston, Massachu setts; Department of Neurology, Boston University School of Medicine/Boston VAMC, 150 South Huntington Avenue, Boston, MA 02130 Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 854 EP - 860 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 40 IS - 8 SN - 0091-2700, 0091-2700 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - High-performance liquid chromatography KW - Intravenous administration KW - Levodopa KW - Data processing KW - Blood-brain barrier KW - Parkinson's disease KW - Brain KW - Metabolites KW - Mass spectroscopy KW - Neurodegenerative diseases KW - Cerebrospinal fluid KW - Dopamine KW - Movement disorders KW - Aromatic-L-amino-acid decarboxylase KW - Decarboxylation KW - X 24310:Pharmaceuticals KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21195817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Pharmacology&rft.atitle=Variable+Absorption+of+Carbidopa+Affects+Both+Peripheral+and+Central+Levodopa+Metabolism&rft.au=Durso%2C+R%3BEvans%2C+JE%3BJosephs%2C+E%3BSzabo%2C+G%3BEvans%2C+B%3BFernandez%2C+H+H%3BBrowne%2C+T+R&rft.aulast=Durso&rft.aufirst=R&rft.date=2000-08-01&rft.volume=40&rft.issue=8&rft.spage=854&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Pharmacology&rft.issn=00912700&rft_id=info:doi/10.1177%2F009127000004000806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Levodopa; Intravenous administration; Data processing; Blood-brain barrier; Parkinson's disease; Brain; Metabolites; Mass spectroscopy; Neurodegenerative diseases; Cerebrospinal fluid; Movement disorders; Dopamine; Aromatic-L-amino-acid decarboxylase; Decarboxylation DO - http://dx.doi.org/10.1177/009127000004000806 ER - TY - JOUR T1 - Cancer Mortality Among the Highest Exposed US Atmospheric Nuclear Test Participants AN - 17761979; 4826837 AB - Of the estimated 205,000 military personnel who participated in the US atmospheric nuclear weapons testing program from 1945 to 1962, less than 1 % had ionizing radiation doses that met or exceeded the current federal occupational guideline for dose of 5 rem (roentgen equivalents in humans) in a 12-month period. The objective of this study was to determine whether veterans who received the highest gamma radiation doses (n = 1010) have experienced increased cancer mortality compared with a group of Navy veterans who received a minimal radiation dose as participants of HARDTACK I (n = 2870). Mortality from all causes of death (relative risk, 1.22; 95 % confidence interval, 1.04 to 1.44) and from all lymphopoietic cancers (relative risk, 3.72; 95 % confidence interval, 1.28 to 10.83) was significantly elevated among the 5-rem cohort compared with the Navy controls. The lack of statistically significant excesses in deaths from many of the known radiogenic cancers suggests that the observed excess mortality may be the result of many factors, of which radiation exposure was only one. JF - Journal of Occupational and Environmental Medicine AU - Dalager, NA AU - Kang, H K AU - Mahan, C M AD - Environmental Epidemiology Service, Veterans Health Administration, Department of Veterans Affairs, 1120 20th Street, NW, Suite 950, Washington, DC 20036, USA Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 798 EP - 805 VL - 42 IS - 8 SN - 1076-2752, 1076-2752 KW - man KW - Toxicology Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - ^a Radiation KW - Military KW - Occupational exposure KW - Mortality KW - Radioactive pollution KW - Cancer KW - Nuclear power plants KW - Ionizing radiation KW - Military personnel KW - H 8000:Radiation Safety/Electrical Safety KW - X 24210:Radiation & radioactive materials KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17761979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Cancer+Mortality+Among+the+Highest+Exposed+US+Atmospheric+Nuclear+Test+Participants&rft.au=Dalager%2C+NA%3BKang%2C+H+K%3BMahan%2C+C+M&rft.aulast=Dalager&rft.aufirst=NA&rft.date=2000-08-01&rft.volume=42&rft.issue=8&rft.spage=798&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Military; Occupational exposure; Ionizing radiation; Mortality; Cancer; Nuclear power plants; Military personnel; ^a Radiation; Radioactive pollution ER - TY - JOUR T1 - Glutamate-mediated neuroprotection against N-methyl-D-aspartate toxicity: A role for metabotropic glutamate receptors AN - 17703201; 4784698 AB - We studied N-methyl-D-aspartate-induced cell death in organotypic hippocampal slices from seven-day-old Wistar rat pups cultured for 12-14 days in a medium containing no added glutamate. Propidium iodide fluorescence intensity was used as an indicator of cell death measured with the help of confocal microscopy. Exposure of slices for 2 h to L-glutamate (1-500 mu M) prior to the N-methyl-D-aspartate challenge significantly reduced N-methyl-D-aspartate-induced cell death. Glutamate at 10 and 500 mu M concentrations was highly protective against N-methyl-D-aspartate-induced cell death, but was less protective at the 1 mu M concentration. The protection was not blocked by the Na super(+) channel blocker tetrodotoxin (1 mu M), the N-methyl-D-aspartate receptor antagonist D-2-amino-5-phosphonopentanoic acid (20 mu M) or the alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (20 mu M). 1S,3R-1-Aminocyclopentane-trans-1,3-dicarboxylic acid, an agonist at metabotropic glutamate receptor types 1, 2/3 and 5, was protective at 100 mu M but not at 50 mu M. In contrast, the ionotropic glutamate receptor agonist aspartate (250 mu M) facilitated N-methyl-D-aspartate toxicity. Treatment of slices with the protein kinase C inhibitor staurosporine (0.2 mu M) or antisense oligonucleotide (10 nM, 72 h) that selectively inhibits metabotropic glutamate receptor type 5 synthesis significantly reduced glutamate protection. These results suggest that ambient glutamate may reduce nerve cell susceptibility to injury caused by excessive N-methyl-D-aspartate receptor activation by acting at metabotropic glutamate receptors linked to protein kinase C. JF - Neuroscience AU - Adamchik, Y AU - Baskys, A AD - Long Beach VA Medical Center, 5901 E. Seventh Street, Long Beach, CA 90822, USA, andrius.baskys@med.va.gov Y1 - 2000/08// PY - 2000 DA - Aug 2000 SP - 731 EP - 736 VL - 99 IS - 4 SN - 0306-4522, 0306-4522 KW - cell culture KW - rats KW - neuroprotection KW - glutamic acid receptors KW - protein kinase C KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Protein kinase C KW - Glutamic acid receptors (metabotropic) KW - N-Methyl-D-aspartic acid receptors KW - Aspartic acid KW - Hippocampus KW - Neuroprotection KW - NMDA KW - Cell death KW - Neurons KW - Neurotoxicity KW - Brain slice preparation KW - Glutamic acid KW - X 24240:Miscellaneous KW - N3 11070:Neurochemistry and cellular biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17703201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Glutamate-mediated+neuroprotection+against+N-methyl-D-aspartate+toxicity%3A+A+role+for+metabotropic+glutamate+receptors&rft.au=Adamchik%2C+Y%3BBaskys%2C+A&rft.aulast=Adamchik&rft.aufirst=Y&rft.date=2000-08-01&rft.volume=99&rft.issue=4&rft.spage=731&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cell death; Neurotoxicity; NMDA; Hippocampus; Glutamic acid; Aspartic acid; Neurons; N-Methyl-D-aspartic acid receptors; Glutamic acid receptors (metabotropic); Protein kinase C; Neuroprotection; Brain slice preparation ER - TY - JOUR T1 - Hypothermia and thermoregulatory derangements induced by valproic acid. AN - 71248989; 10891933 JF - Neurology AU - Zachariah, S B AU - Zachariah, A AU - Ananda, R AU - Stewart, J T AD - Neurology Service, Bay Pines VA Medical Center, University of South Florida College of Medicine, Bay Pines, FL 33744, USA. sally.zachariah@med.va.gov Y1 - 2000/07/12/ PY - 2000 DA - 2000 Jul 12 SP - 150 EP - 151 VL - 55 IS - 1 SN - 0028-3878, 0028-3878 KW - Anticonvulsants KW - 0 KW - Valproic Acid KW - 614OI1Z5WI KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Body Temperature Regulation -- drug effects KW - Hypothermia -- physiopathology KW - Body Temperature Regulation -- physiology KW - Hypothermia -- chemically induced KW - Anticonvulsants -- adverse effects KW - Valproic Acid -- adverse effects KW - Anticonvulsants -- administration & dosage KW - Valproic Acid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71248989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Hypothermia+and+thermoregulatory+derangements+induced+by+valproic+acid.&rft.au=Zachariah%2C+S+B%3BZachariah%2C+A%3BAnanda%2C+R%3BStewart%2C+J+T&rft.aulast=Zachariah&rft.aufirst=S&rft.date=2000-07-12&rft.volume=55&rft.issue=1&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-07 N1 - Date created - 2000-08-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Neurology. 2001 Jan 9;56(1):139 [11148261] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Semantic Capacities of the Right Hemisphere as Seen in Two Cases of Pure Word Blindness AN - 85526984; 200011435 AB - Patients with pure alexia (N = 2) were studied with tachistoscopically presented stimuli to examine factors influencing their ability to distinguish words from nonwords & to derive semantic information of exposures too brief for explicit letter identification. Both patients had profound right hemianopia & computerized tomography (CT) evidence of splenial destruction. Both patients were successful in making word/nonword decisions for high-frequency, but not low-frequency, words. They could judge semantic class membership reliably for such common categories as animals & vegetables, but not for arbitrarily selected categories, eg, office-related items. Judgments about the gender of people's names & place vs person name distinctions were made with high reliability. Results are interpreted as evidence for limited word recognition & semantic-processing capacity in the right hemisphere. 4 Tables, 45 References. Adapted from the source document JF - Journal of Psycholinguistic Research AU - Goodglass, Harold AU - Lindfield, Kimberly C AU - Alexander, Michael P AD - Aphasia Research Center, Dept Veterans Affairs Medical Center, Boston, MA goodglass@boston.va.gov Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 399 EP - 422 VL - 29 IS - 4 SN - 0090-6905, 0090-6905 KW - Cerebral Dominance (11500) KW - Aphasia (03400) KW - Nonsense Words (58350) KW - Word Recognition (98200) KW - Semantic Processing (76760) KW - article KW - 4014: psycholinguistics; semantic processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85526984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psycholinguistic+Research&rft.atitle=Semantic+Capacities+of+the+Right+Hemisphere+as+Seen+in+Two+Cases+of+Pure+Word+Blindness&rft.au=Goodglass%2C+Harold%3BLindfield%2C+Kimberly+C%3BAlexander%2C+Michael+P&rft.aulast=Goodglass&rft.aufirst=Harold&rft.date=2000-07-01&rft.volume=29&rft.issue=4&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psycholinguistic+Research&rft.issn=00906905&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JPLRB7 N1 - SubjectsTermNotLitGenreText - Semantic Processing (76760); Aphasia (03400); Cerebral Dominance (11500); Word Recognition (98200); Nonsense Words (58350) ER - TY - JOUR T1 - Unexpected neurotoxicity of etoposide phosphate administered in combination with other chemotherapeutic agents after blood-brain barrier modification to enhance delivery, using propofol for general anesthesia, in a rat model. AN - 85279515; pmid-10917363 AB - OBJECTIVE: Osmotic blood-brain barrier disruption (BBBD) increases brain and brain tumor delivery of chemotherapeutic agents, which results in increased efficacy against brain tumors. We previously noted that the use of propofol anesthesia for BBBD increased the percentage of successful disruptions, resulting in delivery of increased amounts of chemotherapeutic drugs. This study evaluated the neurotoxicity of combination chemotherapeutic administration with this enhanced delivery system. METHODS: Osmotic BBBD was performed in Long-Evans rats with isoflurane (n = 11) or propofol (n = 90) anesthesia. Carboplatin and/or melphalan, methotrexate, or etoposide phosphate was administered intra-arterially (IA) after BBBD using propofol anesthesia. Animals were assessed for systemic and neurological toxicity. Animals were killed for neuropathological evaluation 30 days after treatment. RESULTS: With propofol or isoflurane anesthesia, BBBD alone produced no systemic or neurological toxicity. Single agents were relatively non-neurotoxic when administered IA with BBBD, as were the combinations of carboplatin or melphalan with methotrexate. Etoposide phosphate in combination with any other agent was observed to be highly neurotoxic if both agents were administered after BBBD. Administration of etoposide phosphate before BBBD completely eliminated neurotoxicity, although acute pulmonary toxicity occurred with any combination of etoposide phosphate and methotrexate, regardless of the timing of administration. CONCLUSION: Neurotoxicity was significantly increased for etoposide phosphate combination groups, particularly when both drugs were administered IA after BBBD. This increase in neurotoxicity may reflect on increase in drug delivery observed with propofol anesthesia. The neurotoxicity of IA administered etoposide phosphate with BBBD and propofol anesthesia could be minimized by administering etoposide phosphate IA before BBBD and administering carboplatin or melphalan IA after BBBD. JF - Neurosurgery AU - Fortin, D AU - McCormick, C I AU - Remsen, L G AU - Nixon, R AU - Neuwelt, E A AD - Department of Neurology, Oregon Health Sciences University, and Veterans Administration Medical Center, Portland, USA. PY - 2000 SP - 199 EP - 207 VL - 47 IS - 1 SN - 0148-396X, 0148-396X KW - Rats KW - Organophosphorus Compounds KW - Rats, Long-Evans KW - Support, U.S. Gov't, P.H.S. KW - Neurotoxicity Syndromes KW - Antineoplastic Agents KW - Antineoplastic Combined Chemotherapy Protocols KW - Animal KW - Support, U.S. Gov't, Non-P.H.S. KW - Etoposide KW - Female KW - Blood-Brain Barrier KW - Anesthetics, Intravenous KW - Anesthesia, General KW - Disease Models, Animal KW - Propofol UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85279515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurosurgery&rft.atitle=Unexpected+neurotoxicity+of+etoposide+phosphate+administered+in+combination+with+other+chemotherapeutic+agents+after+blood-brain+barrier+modification+to+enhance+delivery%2C+using+propofol+for+general+anesthesia%2C+in+a+rat+model.&rft.au=Fortin%2C+D%3BMcCormick%2C+C+I%3BRemsen%2C+L+G%3BNixon%2C+R%3BNeuwelt%2C+E+A&rft.aulast=Fortin&rft.aufirst=D&rft.date=2000-07-01&rft.volume=47&rft.issue=1&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Neurosurgery&rft.issn=0148396X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Issues of fatherhood and recovery for VA substance abuse patients. AN - 72382849; 11061686 AB - Drug-addicted fathers bring to treatment many uncertainties about their relevance to their children. Whether they are in contact with their children or not, they often believe their children are better off without contact with them. In working with these fathers, the authors have observed these men raising a number of issues concerning the father role. These include having no concept of what a father should be, confusing the roles of manhood and fatherhood, feeling inadequate as a provider, and not knowing how to reconnect with children they have not seen, particularly daughters. The fathers also have to learn to deal with their own guilt concerning their abandonment of their children. Suggestions for interventions with the fathers are given and include offering a workshop for fathers where they are shown visual images of positive fathering and can discuss their own parenting experiences. JF - Journal of psychoactive drugs AU - Arenas, M L AU - Greif, G L AD - Special Populations Treatment Program, Baltimore Veterans Administration Medical Center, Maryland 21201, USA. PY - 2000 SP - 339 EP - 341 VL - 32 IS - 3 SN - 0279-1072, 0279-1072 KW - Index Medicus KW - United States KW - Humans KW - Child KW - Female KW - Parenting KW - United States Department of Veterans Affairs KW - Substance-Related Disorders -- rehabilitation KW - Fathers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72382849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=Issues+of+fatherhood+and+recovery+for+VA+substance+abuse+patients.&rft.au=Arenas%2C+M+L%3BGreif%2C+G+L&rft.aulast=Arenas&rft.aufirst=M&rft.date=2000-07-01&rft.volume=32&rft.issue=3&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-15 N1 - Date created - 2001-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gastrin-releasing peptide is a mitogen and a morphogen in murine colon cancer. AN - 71733539; 10939592 AB - Little is known about the factors involved in regulating the appearance, or differentiation, of solid tumors including those arising from the colon. We herein demonstrate that the mitogen gastrin-releasing peptide (GRP) is a morphogen, critically important in regulating the differentiation of murine colon cancer. Although epithelial cells lining the mouse colon do not normally express GRP and its receptor (GRP-R), both are aberrantly expressed by all better differentiated cancers in wild-type C57BL/6J mice treated with the carcinogen azoxymethane. Whereas small tumors in both wild-type and GRP-R-deficient (i.e., GRP-R-/-) mice are histologically similar, larger tumors become better differentiated in the former but degenerate into more poorly differentiated mucinous adenocarcinomas in the latter. This alteration in phenotype is attributable to GRP increasing focal adhesion kinase expression in GRP-R-expressing tumors. Consistent with GRP acting as a mitogen, GRP/GRP-R coexpressing tumors in wild-type animals also contain more proliferating cells than those occurring in GRP-R-/- mice. Yet tumors are similarly sized in animals of either genotype receiving azoxymethane for identical times, a finding attributable to the significantly higher number of apoptotic cells detected in GRP/GRP-R coexpressing cancers. Thus, these findings indicate that although GRP is a mitogen, aberrant expression does not result in increased tumor growth. Rather, the mitogenic properties of GRP are subordinate to it acting as a morphogen, where it and its receptor are critically involved in regulating colon cancer histological progression by promoting a well-differentiated phenotype. JF - Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research AU - Carroll, R E AU - Matkowskyj, K A AU - Tretiakova, M S AU - Battey, J F AU - Benya, R V AD - Department of Medicine, University of Illinois at Chicago, and Chicago Veterans Administration Medical Center, 60612, USA. Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 385 EP - 393 VL - 11 IS - 7 SN - 1044-9523, 1044-9523 KW - Carcinogens KW - 0 KW - Mitogens KW - Receptors, Bombesin KW - Gastrin-Releasing Peptide KW - 80043-53-4 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Focal Adhesion Kinase 1 KW - EC 2.7.10.2 KW - Focal Adhesion Protein-Tyrosine Kinases KW - Proto-Oncogene Proteins pp60(c-src) KW - Ptk2 protein, mouse KW - Azoxymethane KW - MO0N1J0SEN KW - Index Medicus KW - Animals KW - Carcinogens -- pharmacology KW - Apoptosis KW - Proto-Oncogene Proteins pp60(c-src) -- metabolism KW - Azoxymethane -- pharmacology KW - Mice KW - Protein-Tyrosine Kinases -- metabolism KW - Mice, Knockout KW - Epithelial Cells -- metabolism KW - Mice, Inbred C57BL KW - Receptors, Bombesin -- metabolism KW - Receptors, Bombesin -- immunology KW - Cell Division KW - Adenocarcinoma -- metabolism KW - Gastrin-Releasing Peptide -- metabolism KW - Adenocarcinoma -- chemically induced KW - Cell Differentiation KW - Colonic Neoplasms -- metabolism KW - Gastrin-Releasing Peptide -- immunology KW - Colonic Neoplasms -- pathology KW - Colonic Neoplasms -- chemically induced KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71733539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+growth+%26+differentiation+%3A+the+molecular+biology+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Gastrin-releasing+peptide+is+a+mitogen+and+a+morphogen+in+murine+colon+cancer.&rft.au=Carroll%2C+R+E%3BMatkowskyj%2C+K+A%3BTretiakova%2C+M+S%3BBattey%2C+J+F%3BBenya%2C+R+V&rft.aulast=Carroll&rft.aufirst=R&rft.date=2000-07-01&rft.volume=11&rft.issue=7&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Cell+growth+%26+differentiation+%3A+the+molecular+biology+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10449523&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bone marrow granulomas possibly associated with amiodarone. AN - 71231498; 10907978 AB - Amiodarone is a class III antiarrhythmic agent that is effective in treating different types of cardiac dysrhythmias. It was approved only for treatment of life-threatening ventricular dysrhythmias refractory to other therapy; however, its use for atrial dysrhythmias such as atrial fibrillation is well accepted. Adverse effects associated with amiodarone include pulmonary, hepatic, thyroid, ocular, and neurologic toxicities. Our patient experienced intermittent fever, night sweats, and fatigue while taking the drug for treatment of atrial fibrillation. Bone marrow biopsy showed granuloma formation after 17 months of therapy with amiodarone. Amiodarone was discontinued due to significant hypotension and shortness of breath. To our knowledge, this is the third case report of granuloma formation in bone marrow possibly associated with this agent. JF - Pharmacotherapy AU - Yamreudeewong, W AU - McIntyre, W W AU - Sun, T J AU - Ranelli, P L AD - School of Pharmacy, University of Wyoming, Cheyenne Veterans Administration Medical Center, 82001, USA. Y1 - 2000/07// PY - 2000 DA - July 2000 SP - 855 EP - 859 VL - 20 IS - 7 SN - 0277-0008, 0277-0008 KW - Anti-Arrhythmia Agents KW - 0 KW - Amiodarone KW - N3RQ532IUT KW - Index Medicus KW - Bone Marrow -- pathology KW - Atrial Fibrillation -- complications KW - Humans KW - Atrial Fibrillation -- drug therapy KW - Middle Aged KW - Male KW - Granuloma -- chemically induced KW - Bone Marrow Diseases -- pathology KW - Granuloma -- pathology KW - Bone Marrow Diseases -- chemically induced KW - Amiodarone -- therapeutic use KW - Amiodarone -- adverse effects KW - Anti-Arrhythmia Agents -- adverse effects KW - Anti-Arrhythmia Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71231498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Bone+marrow+granulomas+possibly+associated+with+amiodarone.&rft.au=Yamreudeewong%2C+W%3BMcIntyre%2C+W+W%3BSun%2C+T+J%3BRanelli%2C+P+L&rft.aulast=Yamreudeewong&rft.aufirst=W&rft.date=2000-07-01&rft.volume=20&rft.issue=7&rft.spage=855&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antibacterial effect of telithromycin (HMR 3647) and comparative antibiotics against intracellular Legionella pneumophila AN - 17680130; 4751341 AB - The activity of the ketolide telithromycin (HMR 3647) against intracellular Legionella pneumophila strain L-1033 was compared with the activities of erythromycin and levofloxacin. To assay intracellular antibacterial activity, human monocytes were allowed to adhere to wells in 24-well tissue culture plates and were then exposed to L. pneumophila cells for 1 h to allow phagocytosis to occur. Antibiotics were added to the wells after removal of unphagocytosed bacteria. Quantitative bacterial cell counts were made from lysed monocytes at 0, 24, 48, 72 and 96 h. The antibacterial effects of antibiotics against intracellular L. pneumophila L-1033 were concentration and time dependent; at 10 x MIC the activity of telithromycin was greater than that of erythromycin and was less than that of levofloxacin (P < 0.01); telithromycin-rifampicin combinations showed no synergy or interference; and removal of telithromycin from assays at 24 h did not affect its intracellular antibacterial activity. In conclusion, the ketolide telithromycin has excellent activity against intracellular L. pneumophila strain L-1033 and should be evaluated for therapy of legionnaires' disease. JF - Journal of Antimicrobial Chemotherapy AU - Baltch, AL AU - Smith, R P AU - Ritz, W J AU - Franke, MA AU - Michelsen, P B AD - Infectious Disease Section, Stratton VA Medical Center and Albany Medical College, Albany, NY 12208, USA, baltch.aldona_@albany.va.gov Y1 - 2000/07// PY - 2000 DA - Jul 2000 SP - 51 EP - 55 VL - 46 IS - 1 SN - 0305-7453, 0305-7453 KW - telithromycin KW - Microbiology Abstracts B: Bacteriology KW - Legionella pneumophila KW - levofloxacin KW - Phagocytosis KW - Erythromycin KW - Legionnaire's disease KW - J 02786:Macrolide antibiotics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17680130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Antibacterial+effect+of+telithromycin+%28HMR+3647%29+and+comparative+antibiotics+against+intracellular+Legionella+pneumophila&rft.au=Baltch%2C+AL%3BSmith%2C+R+P%3BRitz%2C+W+J%3BFranke%2C+MA%3BMichelsen%2C+P+B&rft.aulast=Baltch&rft.aufirst=AL&rft.date=2000-07-01&rft.volume=46&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Legionella pneumophila; Erythromycin; levofloxacin; Phagocytosis; Legionnaire's disease ER - TY - JOUR T1 - Sexuality in persons with lower extremity amputations. AN - 85347505; pmid-10894204 AB - PURPOSE: There is a paucity of information regarding sexual functioning in persons with lower extremity amputations. The purpose of this study was to describe sexual and psychological functioning and health status in persons with lower extremity amputation. METHODS: Self-report surveys assessed sexual functioning (Derogatis Inventory), depression (Beck Depression Inventory, anxiety (State-Trait Anxiety Inventory), and health status (Health Status Questionnaire) in a convenience sample of 30 men with lower extremity amputations. Mean age of the participants was 57 years (range 32-79). Mean duration since amputation was 23 months (range 3-634 months). Twenty one subjects (70%) had trans-tibial and seven subjects (23%) had trans-femoral amputations. RESULTS: A majority of subjects were experiencing problems in several domains of sexual functioning. Fifty three percent (n = 16) of the subjects were engaged in sexual intercourse or oral sex at least once a month. Twenty seven percent (n = 8) were masturbating at least once a month. Nineteen subjects (63%) reported orgasmic problems and 67% were experiencing erectile difficulties. Despite these problems, interest in sex was high in over 90% of the subjects. There was no evidence of increased prevalence of depression or anxiety in these subjects when compared to other outpatient adult populations. CONCLUSIONS: Sexual problems were common in the subjects studied. Despite these problems, interest in sex remained high. Few investigations have been directed toward identifying the psychological and social factors that may contribute to these problems and more research with a larger population is needed in this area. JF - Disability and rehabilitation AU - Bodenheimer, C AU - Kerrigan, A J AU - Garber, S L AU - Monga, T N AD - Houston VAMC, TX 77030, USA. Bodenheimer,Carol_F+@Houston.VA.gov Y1 - 2000/06/15/ PY - 2000 DA - 2000 Jun 15 SP - 409 EP - 415 VL - 22 IS - 9 SN - 0963-8288, 0963-8288 KW - Index Medicus KW - National Library of Medicine KW - Age Factors KW - Humans KW - Health Status KW - Phantom Limb -- psychology KW - Aged KW - Texas KW - Pilot Projects KW - Sexual Behavior KW - Adaptation, Psychological KW - Adult KW - Middle Aged KW - Artificial Limbs -- psychology KW - Male KW - Female KW - Statistics, Nonparametric KW - Amputees -- rehabilitation KW - Sexuality KW - Amputees -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85347505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Disability+and+rehabilitation&rft.atitle=Sexuality+in+persons+with+lower+extremity+amputations.&rft.au=Bodenheimer%2C+C%3BKerrigan%2C+A+J%3BGarber%2C+S+L%3BMonga%2C+T+N&rft.aulast=Bodenheimer&rft.aufirst=C&rft.date=2000-06-15&rft.volume=22&rft.issue=9&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Disability+and+rehabilitation&rft.issn=09638288&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Recognition of dichotic digits under pre-cued and post-cued response conditions in young and elderly listeners. AN - 85344564; pmid-10905448 AB - Dichotic listening was evaluated in pre-cued and post-cued response conditions using a hierarchical set of one-, two- and three-pair dichotic digit materials. Thirty young adults (mean age 29.1 years) with normal hearing, and 30 older adults in the 60-79-year age range (mean age 68.7 years) with mild-to-moderate sensorineural hearing loss were evaluated. Several patterns of performance were observed. First, recognition performance in the pre-cued condition was better than recognition performance in the post-cued condition for one-, two- and three-pair digits for both age groups. Second, there was a right ear advantage in pre- and post-cued response conditions for both age groups. In the pre-cued condition, the right ear advantage was small owing to ceiling effects associated with ease of the listening task. In the post-cued condition, recognition performance decreased as a function of age, and left ear scores decreased faster than right ear scores, resulting in a larger right ear advantage in the 60-79-year group. Third, as the complexity of the listening task increased from easy (one-pair) to difficult (three-pairs), there was a corresponding decrease in recognition performance for both age groups. The increase in the difference in performance on easy and difficult tasks became larger as a function of age. JF - British journal of audiology AU - Strouse, A AU - Wilson, R H AU - Brush, N AD - Veteran Affairs Medical Center Mountain Home, Tennessee 37684, USA. anne.strouse@med.va.gov Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 141 EP - 151 VL - 34 IS - 3 SN - 0300-5364, 0300-5364 KW - Index Medicus KW - National Library of Medicine KW - Severity of Illness Index KW - Age Factors KW - Humans KW - Adult KW - Aging KW - Aged KW - Middle Aged KW - Hearing Loss, Sensorineural -- diagnosis KW - Speech Perception -- physiology KW - Mental Recall -- physiology KW - Cues KW - Dichotic Listening Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85344564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+audiology&rft.atitle=Recognition+of+dichotic+digits+under+pre-cued+and+post-cued+response+conditions+in+young+and+elderly+listeners.&rft.au=Strouse%2C+A%3BWilson%2C+R+H%3BBrush%2C+N&rft.aulast=Strouse&rft.aufirst=A&rft.date=2000-06-01&rft.volume=34&rft.issue=3&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=British+journal+of+audiology&rft.issn=03005364&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Nonsteroidal anti-inflammatory drugs in the elderly. AN - 72610433; 11706458 AB - Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in the elderly for the treatment of fever, pain, pain associated with inflammation in rheumatoid arthritis and osteoarthritis, neuromuscular disorders, headache, and musculoskeletal conditions. Each year in the United States, people spend 5 to 10 billion dollars to purchase prescription and over-the-counter NSAIDs. Gastrointestinal side effects such as ulcers and bleeding are the most prevalent and life-threatening problems associated with NSAIDs. Specifically in the elderly, NSAIDs have become a leading cause of hospitalization and may increase the risk of death from ulceration more than 4-fold. NSAIDs and the new class of cyclo-oxygenase-2 selective NSAIDs continue as drugs of choice for analgesia and anti-inflammatory effects. Physiological changes of aging worsen the side-effect profile of NSAIDs in the elderly. These side effects, when added to the increased potential for drug interactions, lead to a much greater risk for adverse outcomes when NSAIDs are used in the elderly patient. The similarities and differences in the NSAID agents warrant review in light of the newer drugs--celecoxib and rofecoxib--with their expected improvement in gastrointestinal side effects. This article reviews current information about using NSAIDs in elderly persons. JF - Pain management nursing : official journal of the American Society of Pain Management Nurses AU - Buffum, M AU - Buffum, J C AD - Nursing Service for Research, VA Medical Center, School of Nursing, School of Pharmacy, University of California, San Francisco, CA, USA. Martha.Buffum@med.va.gov Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 40 EP - 50 VL - 1 IS - 2 SN - 1524-9042, 1524-9042 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase Inhibitors KW - Lactones KW - Pyrazoles KW - Sulfonamides KW - Sulfones KW - rofecoxib KW - 0QTW8Z7MCR KW - Celecoxib KW - JCX84Q7J1L KW - Index Medicus KW - Nursing KW - Lactones -- adverse effects KW - Patient Education as Topic KW - Age Factors KW - Sulfonamides -- adverse effects KW - Lactones -- therapeutic use KW - Sulfonamides -- pharmacology KW - Nursing Care KW - Humans KW - Aged KW - Decision Making KW - Sulfonamides -- therapeutic use KW - Lactones -- pharmacology KW - Cyclooxygenase Inhibitors -- therapeutic use KW - Cyclooxygenase Inhibitors -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Cyclooxygenase Inhibitors -- pharmacology KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72610433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain+management+nursing+%3A+official+journal+of+the+American+Society+of+Pain+Management+Nurses&rft.atitle=Nonsteroidal+anti-inflammatory+drugs+in+the+elderly.&rft.au=Buffum%2C+M%3BBuffum%2C+J+C&rft.aulast=Buffum&rft.aufirst=M&rft.date=2000-06-01&rft.volume=1&rft.issue=2&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Pain+management+nursing+%3A+official+journal+of+the+American+Society+of+Pain+Management+Nurses&rft.issn=15249042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-10 N1 - Date created - 2001-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Detox in the ED: taking urgent action. AN - 72597904; 11503240 JF - JAAPA : official journal of the American Academy of Physician Assistants AU - Kuszmar, T J AU - Bell, L AU - Scholz, D M AD - Veterans Administration Maryland Health Care System, Primary Care Manager Domiciliary, Perry Point, USA. Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 43 EP - 4, 47-8, 52-4 VL - 13 IS - 6 SN - 1547-1896, 1547-1896 KW - Health technology assessment KW - Humans KW - Opioid-Related Disorders -- therapy KW - Alcohol-Related Disorders -- therapy KW - Clinical Protocols KW - Substance-Related Disorders -- therapy KW - Emergency Service, Hospital UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72597904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAAPA+%3A+official+journal+of+the+American+Academy+of+Physician+Assistants&rft.atitle=Detox+in+the+ED%3A+taking+urgent+action.&rft.au=Kuszmar%2C+T+J%3BBell%2C+L%3BScholz%2C+D+M&rft.aulast=Kuszmar&rft.aufirst=T&rft.date=2000-06-01&rft.volume=13&rft.issue=6&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=JAAPA+%3A+official+journal+of+the+American+Academy+of+Physician+Assistants&rft.issn=15471896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-11-01 N1 - Date created - 2001-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Investigating patient experiences after a formulary change. AN - 71224117; 10876747 JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Jean, C D AU - Triplett, J W AD - Department of Veterans Affairs Medical Center, Miami, FL 33125, USA. jean.carmela_d@miami.va.gov Y1 - 2000/06/01/ PY - 2000 DA - 2000 Jun 01 SP - 1052 EP - 1054 VL - 57 IS - 11 SN - 1079-2082, 1079-2082 KW - Anti-Allergic Agents KW - 0 KW - Loratadine KW - 7AJO3BO7QN KW - Cetirizine KW - YO7261ME24 KW - Index Medicus KW - Patient Satisfaction KW - Humans KW - Anti-Allergic Agents -- therapeutic use KW - Loratadine -- therapeutic use KW - Loratadine -- adverse effects KW - Cetirizine -- therapeutic use KW - Cetirizine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71224117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Investigating+patient+experiences+after+a+formulary+change.&rft.au=Jean%2C+C+D%3BTriplett%2C+J+W&rft.aulast=Jean&rft.aufirst=C&rft.date=2000-06-01&rft.volume=57&rft.issue=11&rft.spage=1052&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-19 N1 - Date created - 2000-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interaction between warfarin and trazodone. AN - 71191391; 10860134 AB - It is well known that there are many drug interactions involving warfarin. However, few data have been supplied to guide clinicians concerning the interaction between trazodone and warfarin. Three clinically significant cases of suspected trazodone and warfarin interactions were identified in a retrospective chart review based on changes in the prothrombin time (PT) and international normalized ratio (INR) that were not explained by other factors. In each of the cases, the INR changed by > or = 1.0 after the initiation or discontinuation of trazodone. In the patients who started trazodone, a subsequent decrease in the PT and INR resulted; conversely, the PT and INR increased in the patient who stopped trazodone therapy. Although none of the patients experienced adverse effects due to the marked changes in PT and INR, the warfarin dosages had to be adjusted accordingly on initiation and discontinuation of trazodone. These cases show that there is a potentially clinically significant interaction between trazodone and warfarin. The time to onset of the interaction is variable; the mechanism behind it is not known, but it may involve substrate or protein-binding competition. The use of trazodone on an as-needed basis for sleep is strongly discouraged in patients who are receiving warfarin, due to the difficulty of achieving a therapeutic PT and INR. Until more is known, patients and clinicians should be educated about this potential interaction and monitor for changes in the anticoagulant effects when trazodone is initiated or stopped. JF - The Annals of pharmacotherapy AU - Small, N L AU - Giamonna, K A AD - Department of Pharmacy, Central Texas Veterans Healthcare System, Temple 76504, USA. nancy.small@med.va.gov Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 734 EP - 736 VL - 34 IS - 6 SN - 1060-0280, 1060-0280 KW - Anti-Anxiety Agents KW - 0 KW - Anticoagulants KW - Warfarin KW - 5Q7ZVV76EI KW - Trazodone KW - YBK48BXK30 KW - Index Medicus KW - Drug Interactions KW - Aged, 80 and over KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Anticoagulants -- pharmacokinetics KW - Warfarin -- pharmacokinetics KW - International Normalized Ratio KW - Anti-Anxiety Agents -- pharmacokinetics KW - Trazodone -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71191391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Interaction+between+warfarin+and+trazodone.&rft.au=Small%2C+N+L%3BGiamonna%2C+K+A&rft.aulast=Small&rft.aufirst=N&rft.date=2000-06-01&rft.volume=34&rft.issue=6&rft.spage=734&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-18 N1 - Date created - 2000-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuropsychiatric symptoms associated with hepatitis C and interferon alpha: A review. AN - 71149231; 10831463 AB - Neuropsychiatric symptoms are commonly associated with chronic hepatitis C virus infection, its sequelae, and its treatment. In particular, interferon, a primary component of treatment for chronic hepatitis C, has been strongly associated with depressive symptoms. This review summarizes current knowledge about the etiology, course, and treatment of neuropsychiatric problems associated with hepatitis C and interferon alpha (IFN-alpha) treatment. Studies were identified by computerized searches, and further references were obtained from bibliographies of the reviewed articles. Chronic infection with the hepatitis C virus is a common and growing problem, often affecting persons with psychiatric and substance use problems. Although changes in cognition, mood, and personality have been described in association with hepatitis C and with IFN-alpha treatment, there has been little systematic study of these changes. Psychiatrists should become familiar with the clinical spectrum associated with hepatitis C virus infection as well as the neuropsychiatric symptoms related to hepatitis C and IFN-alpha treatment. More studies are necessary to define the neuropsychiatric syndromes associated with this population and to find possible effective treatments. Furthermore, research is needed so that patients with psychiatric problems are not excluded from effective treatments for this growing medical problem. JF - The American journal of psychiatry AU - Dieperink, E AU - Willenbring, M AU - Ho, S B AD - Department of Psychiatry, University of Minnesota and Minneapolis VA Medical Center 55417, USA. Vhamindiepee@MED.VA.GOV Y1 - 2000/06// PY - 2000 DA - June 2000 SP - 867 EP - 876 VL - 157 IS - 6 SN - 0002-953X, 0002-953X KW - Antidepressive Agents KW - 0 KW - Antiviral Agents KW - Interferon-alpha KW - Narcotic Antagonists KW - Abridged Index Medicus KW - Index Medicus KW - Patient Education as Topic KW - Narcotic Antagonists -- therapeutic use KW - Depressive Disorder -- etiology KW - Depressive Disorder -- chemically induced KW - Humans KW - Antidepressive Agents -- therapeutic use KW - Exercise KW - Antiviral Agents -- therapeutic use KW - Interferon-alpha -- therapeutic use KW - Interferon-alpha -- adverse effects KW - Mental Disorders -- therapy KW - Mental Disorders -- chemically induced KW - Hepatitis C, Chronic -- epidemiology KW - Hepatitis C, Chronic -- drug therapy KW - Hepatitis C, Chronic -- complications KW - Mental Disorders -- etiology KW - Antiviral Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71149231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Neuropsychiatric+symptoms+associated+with+hepatitis+C+and+interferon+alpha%3A+A+review.&rft.au=Dieperink%2C+E%3BWillenbring%2C+M%3BHo%2C+S+B&rft.aulast=Dieperink&rft.aufirst=E&rft.date=2000-06-01&rft.volume=157&rft.issue=6&rft.spage=867&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-29 N1 - Date created - 2000-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cardiovascular fitness, body composition, and lipoprotein lipid metabolism in older men. AN - 18146068; 4867247 AB - BACKGROUND: Lipoprotein lipids in older individuals are affected by family history of coronary artery disease (CAD), obesity, diet, and physical activity habits. METHODS: The relationship of obesity and physical fitness (VO2max) to lipoprotein lipids and postheparin lipases was examined in a cross-sectional study of 12 lean (LS) and 26 obese (OS) sedentary men and 18 master athletes (MAs) aged 65+/-1 years (mean +/- SE). The men were healthy, had no family history of CAD, and were weight stable on AHA diets at the time of study. RESULTS: VO2max was similar in LS and OS men but higher in the MAs. The OS men had a higher percentage of body fat (%BF), waist circumference, and waist:hip ratio (WHR) than the MA and LS men, but MA and LS men differed only in waist circumference. Total and LDL-C levels were comparable, but HDL-C, HDL2-C, and %HDL2b subspecies were higher in MAs than in OS and LS men, and in LS than in OS men. Triglyceride (TG) was similar in MAs and LS men but higher in OS men. Across groups, two multiple regression analyses models (VO2max, %BF, and WHR or waist circumference) showed that %BF and VO2max independently predicted HDL-C and HDL2, whereas WHR predicted TG (r2 = .45) more strongly than waist circumference (r2 = .39). Postheparin lipoprotein lipase activity (LPL) was comparable among groups and correlated independently with VO2max. Total postheparin lipolytic activity (PHLA), hepatic lipase activity (HL), and HL:PHLA ratio were similar in MAs and LS men but higher in OS men. In both multiple regression analysis models, only %BF predicted HL activity and the HL:PHLA ratio. The HL:PHLA ratio independently predicted HDL-C, HDL2-C, %HDL2b, %HDL3 subspecies, and the cholesterol:HDL-C ratio, whereas LPL activity predicted TG. CONCLUSIONS: Increased fitness and reduced total and abdominal fatness in MAs are associated with lower HL and higher LPL activities, which may mediate their higher HDL-C and lower TG levels relative to their sedentary peers. JF - Journal of Gerontology. Series A AU - Goldberg, A P AU - Busby-Whitehead, MJ AU - Katzel, LI AU - Krauss, R M AU - Lumpkin, M AU - Hagberg, J M AD - Department of Medicine, University of Maryland School of Medicine, Baltimore Veterans Administration Maryland Health Care System, USA. apgoldbe.umaryland.edu. Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - M342 EP - M349 VL - 55 IS - 6 SN - 1079-5006, 1079-5006 KW - Physical Education Index KW - Physical fitness (age) KW - Men KW - Lipids KW - Geriatrics KW - Body composition KW - Cardiorespiratory endurance KW - Metabolism KW - Heart diseases KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18146068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Gerontology.+Series+A&rft.atitle=Cardiovascular+fitness%2C+body+composition%2C+and+lipoprotein+lipid+metabolism+in+older+men.&rft.au=Goldberg%2C+A+P%3BBusby-Whitehead%2C+MJ%3BKatzel%2C+LI%3BKrauss%2C+R+M%3BLumpkin%2C+M%3BHagberg%2C+J+M&rft.aulast=Goldberg&rft.aufirst=A&rft.date=2000-06-01&rft.volume=55&rft.issue=6&rft.spage=M342&rft.isbn=&rft.btitle=&rft.title=Journal+of+Gerontology.+Series+A&rft.issn=10795006&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Body composition; Metabolism; Lipids; Physical fitness (age); Geriatrics; Cardiorespiratory endurance; Heart diseases; Men ER - TY - JOUR T1 - Evaluation of Rifalazil in Long-Term Treatment Regimens for Tuberculosis in Mice AN - 17600275; 4715920 AB - Previous experiments with rifalazil (RLZ) (also known as KRM-1648) in combination with isoniazid (INH) demonstrated its potential for short-course treatment of Mycobacterium tuberculosis infection. In this study we investigated the minimum RLZ-INH treatment time required to eradicate M. tuberculosis in a murine model. RLZ-INH treatment for 6 weeks or longer led to a nonculturable state. Groups of mice treated in parallel were killed following an observation period to evaluate regrowth. RLZ-INH treatment for a minimum of 10 weeks was necessary to maintain a nonculturable state through the observation period. Pyrazinamide (PZA) was added to this regimen to determine whether the treatment duration could be further reduced. In this model, the addition of PZA did not shorten the duration of RLZ-INH treatment required to eradicate M. tuberculosis from mice. The addition of PZA reduced the number of mice in which regrowth occurred, although the reduction was not statistically significant. JF - Antimicrobial Agents & Chemotherapy AU - Shoen, C M AU - Chase, SE AU - DeStefano AU - Harpster, T S AU - Chmielewski, A J AU - Cynamon, M H AD - VAMC, 800 Irving Ave., Syracuse, NY 13210, USA, Michael.Cynamon@med.VA.gov Y1 - 2000/06// PY - 2000 DA - Jun 2000 SP - 1458 EP - 1462 PB - American Society for Microbiology VL - 44 IS - 6 SN - 0066-4804, 0066-4804 KW - mice KW - rifalazil KW - Microbiology Abstracts B: Bacteriology KW - Lung KW - Tuberculosis KW - Antitubercular agents KW - Mycobacterium tuberculosis KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17600275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Evaluation+of+Rifalazil+in+Long-Term+Treatment+Regimens+for+Tuberculosis+in+Mice&rft.au=Shoen%2C+C+M%3BChase%2C+SE%3BDeStefano%3BHarpster%2C+T+S%3BChmielewski%2C+A+J%3BCynamon%2C+M+H&rft.aulast=Shoen&rft.aufirst=C&rft.date=2000-06-01&rft.volume=44&rft.issue=6&rft.spage=1458&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.44.6.1458-1462.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Tuberculosis; Antitubercular agents; Lung DO - http://dx.doi.org/10.1128/AAC.44.6.1458-1462.2000 ER - TY - JOUR T1 - Depression of constitutive murine cytochromes P450 by staphylococcal enterotoxin B. AN - 71003067; 10736430 AB - Most in vivo studies demonstrating decreased activities of hepatic cytochromes P450 with inflammation have used Gram-negative bacterial lipopolysaccharide (LPS) as the inflammatory stimulant. But products of Gram-positive bacteria, such as staphylococcal enterotoxin B (SEB), also stimulate inflammatory mediators, albeit with a different pattern than LPS. Therefore, effects of SEB on the regulation of murine constitutive P450s were determined in this study and compared with those of LPS. LPS-responsive C3H/HeN and LPS-unresponsive C3H/HeJ mice were injected with either LPS (0.5 mg/kg) or SEB (0.66 to 6.6 mg/kg), and hepatic cytochromes P450 and serum tumor necrosis factor-alpha, interleukin-6, nitrate/nitrite, and serum amyloid A concentrations were determined up to 24 hr. HeJ mice were generally less responsive than HeN mice to both stimuli, with lower cytokine, nitrate/nitrite, and serum amyloid A responses. However, in both mouse strains SEB caused more prolonged cytokine, higher nitrate/nitrite, and lower serum amyloid A concentrations than LPS. Despite these differences, in HeN mice, after both SEB and LPS administration, total P450 concentrations were equally depressed by 40%. Both SEB and LPS depressed CYP1A1 and 1A2 microsomal protein concentrations by 45 and 30%, respectively; CYP2E1 by 64%; and CYP3A by 70%. There was comparable inhibition of enzymatic activities. In HeJ mice, SEB was only slightly more effective in depressing P450s than LPS, as might be expected. These data showed that the Gram-positive bacterial inflammatory stimulant SEB caused effects on murine hepatic cytochromes P450 similar to those of LPS, even though the pattern of inflammatory mediators induced after SEB exposure was different. JF - Biochemical pharmacology AU - Shedlofsky, S I AU - Tosheva, R T AU - Snawder, J A AD - Department of Veterans Affairs Medical Center/University of Kentucky, Lexington, KY 40511, USA. Shedlofsky.Steve@Lexington.VA.Gov Y1 - 2000/05/15/ PY - 2000 DA - 2000 May 15 SP - 1295 EP - 1303 VL - 59 IS - 10 SN - 0006-2952, 0006-2952 KW - Enterotoxins KW - 0 KW - Inflammation Mediators KW - Lipopolysaccharides KW - enterotoxin B, staphylococcal KW - 39424-53-8 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Mice, Inbred C3H KW - Inflammation Mediators -- pharmacology KW - Mice KW - Staphylococcus aureus KW - Time Factors KW - Species Specificity KW - Male KW - Enterotoxins -- immunology KW - Lipopolysaccharides -- immunology KW - Cytochrome P-450 Enzyme System -- genetics KW - Lipopolysaccharides -- pharmacology KW - Lipopolysaccharides -- toxicity KW - Enterotoxins -- pharmacology KW - Cytochrome P-450 Enzyme System -- metabolism KW - Enterotoxins -- toxicity KW - Cytochrome P-450 Enzyme System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71003067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Depression+of+constitutive+murine+cytochromes+P450+by+staphylococcal+enterotoxin+B.&rft.au=Shedlofsky%2C+S+I%3BTosheva%2C+R+T%3BSnawder%2C+J+A&rft.aulast=Shedlofsky&rft.aufirst=S&rft.date=2000-05-15&rft.volume=59&rft.issue=10&rft.spage=1295&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-17 N1 - Date created - 2000-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Linguistic Validation of Four Parallel Forms of a Story Retelling Procedure AN - 85522786; 200011378 AB - This study reports the development & validation of four parallel forms of a story retelling procedure. The equivalency of forms was based on the performance of 15 adults with aphasia on 12 operationally defined productive language variables including measures of (1) verbal productivity, (2) information content, (3) grammatical well-formedness, (4) phoneme production, & (5) verbal disruptions. The results revealed no significant differences among the four forms of the test for any of the dependent measures, & strong, positive & significant correlations among forms for 11 of the 12 dependent measures. These results suggest that a wide variety of productive language variables can be reliably measured using parallel forms of the story-retelling procedure described herein. 5 Tables, 1 Appendix, 23 References. Adapted from the source document JF - Aphasiology AU - Doyle, Patrick J AU - McNeil, Malcolm R AU - Park, Grace AU - Goda, Amy AU - Rubenstein, Elaine AU - Spencer, Kristie AU - Carroll, Brian AU - Lustig, Amy AU - Szwarc, Leslie AD - Aphasia Rebilitation Research Laboratory & Clinic, VA Pittsburgh Healthcare System, VA Medical Center, PA patrick.doyle@med.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 537 EP - 549 VL - 14 IS - 5-6 SN - 0268-7038, 0268-7038 KW - Aphasia (03400) KW - Story Telling (84400) KW - Information Content (35890) KW - Measures (Instruments) (52300) KW - Well Formedness (96100) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85522786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Linguistic+Validation+of+Four+Parallel+Forms+of+a+Story+Retelling+Procedure&rft.au=Doyle%2C+Patrick+J%3BMcNeil%2C+Malcolm+R%3BPark%2C+Grace%3BGoda%2C+Amy%3BRubenstein%2C+Elaine%3BSpencer%2C+Kristie%3BCarroll%2C+Brian%3BLustig%2C+Amy%3BSzwarc%2C+Leslie&rft.aulast=Doyle&rft.aufirst=Patrick&rft.date=2000-05-01&rft.volume=14&rft.issue=5-6&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Story Telling (84400); Information Content (35890); Well Formedness (96100); Measures (Instruments) (52300) ER - TY - JOUR T1 - Significant interaction between clozapine and cocaine in cocaine addicts. AN - 71223990; 10891628 AB - Because clozapine may be prescribed to cocaine abusing patients with schizophrenia, we studied cocaine-clozapine interactions in a controlled setting. Eight male cocaine addicts underwent four oral challenges with ascending doses of clozapine (12.5, 25 and 50 mg) and placebo followed 2 h later by a 2-mg/kg dose of intranasal cocaine. Subjective and physiological responses, and serum cocaine levels were measured over a total 4-h period. Clozapine pretreatment increased cocaine levels during the study and significantly increased the peak serum cocaine levels in a dose dependent manner. In spite of this elevation in blood levels, clozapine pretreatment had a significant diminishing effect upon subjective responses to cocaine, including 'expected high', 'high' and 'rush', notably at the 50 mg dose. There was also a significant effect upon 'sleepiness', 'paranoia' and 'nervous'. Clozapine caused a significant near-syncopal episode in one subject in the study, requiring his removal from the study. Clozapine had no significant effect on baseline pulse rate and systolic blood pressure, but it attenuated the significant pressor effects of the single dose of intranasal cocaine. These data suggested a possible therapeutic role for clozapine in the treatment of cocaine addiction in humans, but also suggests caution due to the near-syncopal event and the increase in serum cocaine levels. JF - Drug and alcohol dependence AU - Farren, C K AU - Hameedi, F A AU - Rosen, M A AU - Woods, S AU - Jatlow, P AU - Kosten, T R AD - Department of Psychiatry, Division of Substance Abuse, Yale University School of Medicine, New Haven, CT, USA. conor.farren@med.va.gov Y1 - 2000/05/01/ PY - 2000 DA - 2000 May 01 SP - 153 EP - 163 VL - 59 IS - 2 SN - 0376-8716, 0376-8716 KW - Cocaine KW - I5Y540LHVR KW - Clozapine KW - J60AR2IKIC KW - Index Medicus KW - Euphoria -- drug effects KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Arousal -- drug effects KW - Risk Factors KW - Humans KW - Adult KW - Male KW - Comorbidity KW - Syncope -- chemically induced KW - Clozapine -- therapeutic use KW - Schizophrenia -- rehabilitation KW - Cocaine -- pharmacokinetics KW - Clozapine -- adverse effects KW - Cocaine-Related Disorders -- rehabilitation KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71223990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Significant+interaction+between+clozapine+and+cocaine+in+cocaine+addicts.&rft.au=Farren%2C+C+K%3BHameedi%2C+F+A%3BRosen%2C+M+A%3BWoods%2C+S%3BJatlow%2C+P%3BKosten%2C+T+R&rft.aulast=Farren&rft.aufirst=C&rft.date=2000-05-01&rft.volume=59&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-08 N1 - Date created - 2001-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hyperglycemia associated with protease inhibitors in an urban HIV-infected minority patient population. AN - 71175162; 10852083 AB - Hyperglycemia and new-onset diabetes mellitus have been reported to occur in HIV-infected patients treated with protease inhibitors. To determine the effect of protease inhibitor therapy on serum glucose in a predominantly minority patient population. Retrospective record review. Clinical HIV program of an urban Veterans Affairs medical center. All HIV-infected patients receiving a protease inhibitor over a one-year period from September 1996 through August 1997. One hundred seventeen patients not previously known to be diabetic received protease inhibitors; seven (6%) developed symptomatic diabetes mellitus. Eight other patients had one or more serum glucose values >150 mg/dL. Mean random glucose values for patients who did not develop diabetes were higher during therapy than prior to initiation of protease inhibitors. Urban minority HIV-infected patients receiving combination antiretroviral therapy including a protease inhibitor may be at increased risk for the development of hyperglycemia and diabetes mellitus. Risk factors for diabetes mellitus should be identified and blood glucose monitored in all patients receiving protease inhibitors. JF - The Annals of pharmacotherapy AU - Dever, L L AU - Oruwari, P A AU - Figueroa, W E AU - O'Donovan, C A AU - Eng, R H AD - Infectious Diseases Clinic, Veterans Affairs New Jersey Health Care System, East Orange 07018, USA. dever.lisa@east-orange.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 580 EP - 584 VL - 34 IS - 5 SN - 1060-0280, 1060-0280 KW - Blood Glucose KW - 0 KW - HIV Protease Inhibitors KW - Indinavir KW - 5W6YA9PKKH KW - Saquinavir KW - L3JE09KZ2F KW - Ritonavir KW - O3J8G9O825 KW - Index Medicus KW - AIDS/HIV KW - Urban Population -- statistics & numerical data KW - Humans KW - Minority Groups -- statistics & numerical data KW - Retrospective Studies KW - Indinavir -- therapeutic use KW - Blood Glucose -- analysis KW - Indinavir -- adverse effects KW - Saquinavir -- therapeutic use KW - Ritonavir -- therapeutic use KW - Risk Factors KW - Adult KW - Saquinavir -- adverse effects KW - Middle Aged KW - Ritonavir -- adverse effects KW - Female KW - Male KW - Hyperglycemia -- chemically induced KW - HIV Infections -- drug therapy KW - HIV Protease Inhibitors -- therapeutic use KW - HIV Protease Inhibitors -- adverse effects KW - Diabetes Mellitus, Type 2 -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71175162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Hyperglycemia+associated+with+protease+inhibitors+in+an+urban+HIV-infected+minority+patient+population.&rft.au=Dever%2C+L+L%3BOruwari%2C+P+A%3BFigueroa%2C+W+E%3BO%27Donovan%2C+C+A%3BEng%2C+R+H&rft.aulast=Dever&rft.aufirst=L&rft.date=2000-05-01&rft.volume=34&rft.issue=5&rft.spage=580&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-28 N1 - Date created - 2000-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estrogen potentiates treatment with T-cell receptor protein of female mice with experimental encephalomyelitis. AN - 71119639; 10811854 AB - Transgenic mice expressing the BV8S2 chain, which is specific for the myelin basic protein determinant Ac1-11, possess a naturally induced set of regulatory T cells directed against BV8S2. Further activation of anti-BV8S2 T cells in male mice with recombinant BV8S2 protein can inhibit IFN-gamma release by Ac1-11-specific T cells through a cytokine-driven mechanism and prevent induction of experimental autoimmune encephalomyelitis (EAE). In contrast, naive female mice possess fewer anti-BV8S2-reactive T cells, and treatment with BV8S2 delayed but did not prevent EAE. We here demonstrate that combining T-cell receptor (TCR) vaccination with supplemental estrus doses of estrogen potentiated IL-10 production by anti-BV8S2-reactive T cells and induced Ac1-11-specific T cells to produce IL-10 and TGF-beta. This combined treatment resulted in full protection against EAE, which was not observed with either therapy alone. These findings imply that supplemental estrogen can enhance the efficacy of TCR-based immunotherapy for autoimmune diseases that predominate in females. JF - The Journal of clinical investigation AU - Offner, H AU - Adlard, K AU - Zamora, A AU - Vandenbark, A A AD - Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97201, USA. offner.halina@portland.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 1465 EP - 1472 VL - 105 IS - 10 SN - 0021-9738, 0021-9738 KW - Myelin Basic Protein KW - 0 KW - Peptide Fragments KW - Receptors, Antigen, T-Cell KW - myelin basic protein 1-11 KW - Estradiol KW - 4TI98Z838E KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Myelin Basic Protein -- genetics KW - Peptide Fragments -- genetics KW - Sex Characteristics KW - Immunotherapy KW - Mice KW - Mice, Transgenic KW - Vaccination KW - Peptide Fragments -- immunology KW - Drug Synergism KW - Female KW - Male KW - Myelin Basic Protein -- immunology KW - Encephalomyelitis, Autoimmune, Experimental -- prevention & control KW - Estradiol -- administration & dosage KW - Receptors, Antigen, T-Cell -- administration & dosage KW - Encephalomyelitis, Autoimmune, Experimental -- immunology KW - Encephalomyelitis, Autoimmune, Experimental -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71119639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Estrogen+potentiates+treatment+with+T-cell+receptor+protein+of+female+mice+with+experimental+encephalomyelitis.&rft.au=Offner%2C+H%3BAdlard%2C+K%3BZamora%2C+A%3BVandenbark%2C+A+A&rft.aulast=Offner&rft.aufirst=H&rft.date=2000-05-01&rft.volume=105&rft.issue=10&rft.spage=1465&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-12 N1 - Date created - 2000-06-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arthritis Rheum. 1983 Sep;26(9):1155-9 [6615567] J Steroid Biochem. 1983 May;18(5):559-63 [6855231] Am J Reprod Immunol. 1984 Apr-May;5(3):109-13 [6204544] Ann Neurol. 1984 Aug;16(2):229-31 [6476794] J Neurol Sci. 1985 Apr;68(1):15-24 [3872929] Am J Pathol. 1985 Dec;121(3):531-51 [3907369] Leuk Res. 1985;9(11):1373-8 [4079452] J Neurol Sci. 1987 Jun;79(1-2):173-88 [2440996] Scand J Immunol. 1988 Sep;28(3):345-50 [2973658] Annu Rev Immunol. 1989;7:145-73 [2523712] J Immunol. 1990 Jun 15;144(12):4621-7 [1693637] Arch Neurol. 1990 Jul;47(7):738-42 [1972617] J Immunol. 1998 Oct 1;161(7):3299-306 [9759845] J Immunol. 1998 Oct 1;161(7):3365-74 [9759853] Arthritis Rheum. 1998 Nov;41(11):1919-29 [9811045] J Immunol. 1999 Jan 1;162(1):35-40 [9886367] J Immunol. 1991 May 15;146(10):3444-51 [1827484] J Steroid Biochem Mol Biol. 1991;40(4-6):619-37 [1958562] J Neuroimmunol. 1992 Jun;38(3):229-40 [1376328] Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6065-9 [1385868] Cell. 1993 Feb 26;72(4):551-60 [7679952] J Exp Med. 1993 Sep 1;178(3):909-16 [7688792] Immunol Today. 1993 Jul;14(7):353-6 [8363725] Int Arch Allergy Immunol. 1993;102(2):133-40 [8400893] J Immunol. 1993 Oct 15;151(8):4371-82 [7691946] Immunol Today. 1993 Dec;14(12):602-9 [8305133] Annu Rev Immunol. 1994;12:809-37 [8011298] Science. 1994 Aug 26;265(5176):1237-40 [7520605] J Neuroimmunol. 1994 Sep;53(2):203-7 [8071434] Immunol Today. 1994 Aug;15(8):356-61 [7916948] Science. 1994 Dec 2;266(5190):1524-7 [7985022] Cell. 1995 Mar 10;80(5):707-18 [7534215] J Neurosci Res. 1996 Feb 15;43(4):391-402 [8699526] Ann Neurol. 1996 Jun;39(6):724-33 [8651644] Nat Med. 1996 Oct;2(10):1109-15 [8837609] Neuroendocrinology. 1996 Aug;64(2):139-45 [8857608] Immunol Today. 1996 Apr;17(4):152-9 [8871344] J Neurosci Res. 1996 Aug 15;45(4):475-86 [8872909] J Neurosci Res. 1996 Sep 15;45(6):680-9 [8892079] Nat Med. 1996 Dec;2(12):1354-60 [8946835] J Immunol. 1997 Jan 1;158(1):446-51 [8977221] J Neurosci Res. 1997 Mar 1;47(5):489-99 [9067858] J Exp Med. 1997 May 5;185(9):1711-4 [9151908] J Exp Med. 1997 Jul 7;186(1):159-64 [9207010] J Exp Med. 1997 Jul 21;186(2):307-12 [9221760] Immunol Today. 1997 Oct;18(10):478-82 [9357139] FEBS Lett. 1998 Feb 6;422(3):349-53 [9498814] N Engl J Med. 1998 Jul 30;339(5):285-91 [9682040] J Immunol. 1998 Sep 1;161(5):2178-86 [9725209] Autoimmunity. 1999;31(4):237-48 [10789989] J Immunol. 1983 Jan;130(1):191-4 [6183347] J Immunol. 1983 Mar;130(3):1024-6 [6185565] J Immunol. 1983 Dec;131(6):2767-71 [6605988] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anger Management Group: Treatment for Cocaine Dependence: Preliminary Outcomes AN - 61661264; 200005799 AB - A sample of 59 men & 32 women with a diagnosis of cocaine dependence attended a 12-week anger management group treatment conducted in San Francisco, CA, & background substance abuse treatment. Levels of anger, negative affect, & anger control were measured at baseline, weekly during treatment, & at 3-month posttreatment follow-up. Levels of anger decreased & anger control increased between baseline & the end of treatment. End-of-treatment changes were maintained at follow-up. Findings were not moderated by gender, age, or psychiatric medication use. In the absence of a randomized control group, conclusive statements regarding the effectiveness of the anger management group treatment cannot be made; however, these preliminary findings demonstrate the need for a randomized clinical trial to test the efficacy of the anger management group treatment. 4 Figures, 16 References. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Reilly, Patrick M AU - Shopshire, Michael S AD - San Francisco Medical Center, CA reilly.patrick_m@sanfrancisco.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 161 EP - 177 VL - 26 IS - 2 SN - 0095-2990, 0095-2990 KW - Treatment Outcomes KW - Treatment Programs KW - Behavior Modification KW - Males KW - Group Therapy KW - Females KW - Cocaine KW - San Francisco, California KW - Anger KW - Drug Abuse KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61661264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Anger+Management+Group%3A+Treatment+for+Cocaine+Dependence%3A+Preliminary+Outcomes&rft.au=Reilly%2C+Patrick+M%3BShopshire%2C+Michael+S&rft.aulast=Reilly&rft.aufirst=Patrick&rft.date=2000-05-01&rft.volume=26&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Anger; Treatment Programs; Drug Abuse; Cocaine; Behavior Modification; Group Therapy; Treatment Outcomes; Males; Females; San Francisco, California ER - TY - JOUR T1 - Type IV collagen modulates angiogenesis and neovessel survival in the rat aorta model AN - 17668631; 4752727 AB - Type IV collagen is a major basement membrane component that has been implicated in the regulation of angiogenesis. The purpose of this study was to evaluate the effect of type IV collagen on the angiogenic response of native endothelial cells in three-dimensional vascular organ culture. Rings of rat aorta were cultured under serum-free conditions in gels of type I collagen with or without type IV collagen. In the absence of type IV collagen, aortic rings generated neovessels, which proliferated until day 9 and gradually regressed during the second and third weeks of culture. Type IV collagen promoted neovessel elongation and survival in a dose-dependent manner. Microvascular length increased by 43, 57, and 119% over control values in cultures treated with 3, 30, and 300 mu g/ml type IV collagen, respectively. When used at high concentrations (300 mu g/ml) type IV collagen stabilized the neovascular outgrowths and prevented vascular regression. Type IV collagen also promoted the formation of neovessels, but significant stimulatory effects were observed only at an intermediate concentration (30 mu g/ml) and were no longer significant at the high concentration (300 mu g/ml). The observation that type IV collagen has dose-dependent effects on vascular elongation, proliferation, and stabilization, supports the concept that the developing basement membrane of neovessels acts as a solid-phase regulator of angiogenesis, whose function varies depending on the concentration of its molecular components. JF - In Vitro Cellular & Developmental Biology - Animal AU - Bonanno, E AU - Iurlaro, M AU - Madri, JA AU - Nicosia, R F AD - Diagnostic Services, Division of Pathology and Laboratory Medicine (S-113-Lab), VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, Washington 98108, USA, Roberto.Nicosia@med.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 336 EP - 340 PB - [URL:http://journals.allenpress.com/jrnlserv/?request=get-abstract &issn=1071-2690&volume=36&page=336] VL - 36 IS - 5 SN - 1071-2690, 1071-2690 KW - rats KW - Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts KW - Collagen (type IV) KW - Blood vessels KW - Basement membranes KW - Aorta KW - Angiogenesis KW - W2 32070:Animals KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17668631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.atitle=Type+IV+collagen+modulates+angiogenesis+and+neovessel+survival+in+the+rat+aorta+model&rft.au=Bonanno%2C+E%3BIurlaro%2C+M%3BMadri%2C+JA%3BNicosia%2C+R+F&rft.aulast=Bonanno&rft.aufirst=E&rft.date=2000-05-01&rft.volume=36&rft.issue=5&rft.spage=336&rft.isbn=&rft.btitle=&rft.title=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.issn=10712690&rft_id=info:doi/10.1290%2F1071-2690%282000%29036%280336%3ATICMAA%292.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Collagen (type IV); Angiogenesis; Aorta; Basement membranes; Blood vessels DO - http://dx.doi.org/10.1290/1071-2690(2000)036(0336:TICMAA)2.0.CO;2 ER - TY - JOUR T1 - Occurrence and detection of AmpC beta-lactamases among Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates at a veterans medical center AN - 17553502; 4733966 AB - AmpC beta-lactamases are cephalosporinases that confer resistance to a wide variety of beta -lactam drugs and that may thereby create serious therapeutic problems. Although reported with increasing frequency, the true rate of occurrence of AmpC beta-lactamases in Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis remains unknown. We tested a total of 1,286 consecutive, nonrepeat isolates of these three species and found that, overall, 45 (3.5%) yielded a cefoxitin zone diameter less than 18 mm (screen positive) and that 16 (1.2%) demonstrated AmpC bands by isoelectric focusing. Based on the species, of 683 E. coli, 371 K. pneumoniae, and 232 P. mirabilis isolates tested, 13 (1.9%), 28 (7.6%), and 4 (1.7%), respectively, demonstrated decreased zone diameters and 11 (1.6%), 4 (1.1%), and 1 (0.4%), respectively, demonstrated AmpC bands. Cefoxitin resistance was transferred for all but 8 (E. coli) of the 16 AmpC producers. We also describe a three-dimensional extract test, which was used to detect phenotypically isolates that harbor AmpC beta-lactamase. Of the 45 cefoxitin-resistant isolates, the three-dimensional extract test accurately identified all 16 AmpC producers and 28 of 29 (97%) isolates as non-AmpC producers. Interestingly, most (86%) isolates in the latter group were K. pneumoniae isolates. These data confirm that, at our institution, E. coli, K. pneumoniae, and P. mirabilis harbor plasmid-mediated AmpC enzymes. JF - Journal of Clinical Microbiology AU - Coudron, P E AU - Moland, E S AU - Thomson, K S AD - Pathology and Laboratory Medicine Service/113, McGuire Veterans Affairs Medical Center, 1201 Broad Rock Blvd., Richmond, VA 23249-0001, USA, Philip.Coudron@med.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 1791 EP - 1796 VL - 38 IS - 5 SN - 0095-1137, 0095-1137 KW - AmpC protein KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Isoelectric focusing KW - Proteus mirabilis KW - Escherichia coli KW - b-Lactamase KW - Antibacterial agents KW - ^b-Lactamase KW - Cefoxitin KW - Antibiotic resistance KW - Klebsiella pneumoniae KW - A 01064:Microbial resistance KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17553502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Occurrence+and+detection+of+AmpC+beta-lactamases+among+Escherichia+coli%2C+Klebsiella+pneumoniae%2C+and+Proteus+mirabilis+isolates+at+a+veterans+medical+center&rft.au=Coudron%2C+P+E%3BMoland%2C+E+S%3BThomson%2C+K+S&rft.aulast=Coudron&rft.aufirst=P&rft.date=2000-05-01&rft.volume=38&rft.issue=5&rft.spage=1791&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Proteus mirabilis; Klebsiella pneumoniae; b-Lactamase; Antibacterial agents; Cefoxitin; Antibiotic resistance; Isoelectric focusing; ^b-Lactamase ER - TY - JOUR T1 - Geographic distribution of a large mobile element that transfers ampicillin and vancomycin resistance between Enterococcus faecium strains AN - 17544679; 4724011 AB - In several clonally unrelated VanB-type vancomycin-resistant Enterococcus faecium strains, we demonstrated a common physical relationship between pbp5 and Tn5382 as well as common mutations within pbp5. The majority of these strains transferred vancomycin and ampicillin resistance to E. faecium in vitro, suggesting the dissemination of similar transferable pbp5-vanB-containing mobile elements throughout the United States. JF - Antimicrobial Agents & Chemotherapy AU - Hanrahan, J AU - Hoyen, C AU - Rice, L B AD - Medical Service 111(W), VA Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA, louis.rice@med.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 SP - 1349 EP - 1351 VL - 44 IS - 5 SN - 0066-4804, 0066-4804 KW - Transposon Tn5382 KW - USA KW - pbp5 gene KW - Microbiology Abstracts B: Bacteriology KW - Geographical distribution KW - Gene transfer KW - Drug resistance KW - Vancomycin KW - Ampicillin KW - Antibacterial agents KW - Mutation KW - Enterococcus faecium KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17544679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Geographic+distribution+of+a+large+mobile+element+that+transfers+ampicillin+and+vancomycin+resistance+between+Enterococcus+faecium+strains&rft.au=Hanrahan%2C+J%3BHoyen%2C+C%3BRice%2C+L+B&rft.aulast=Hanrahan&rft.aufirst=J&rft.date=2000-05-01&rft.volume=44&rft.issue=5&rft.spage=1349&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.44.5.1349-1351.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Enterococcus faecium; Antibacterial agents; Ampicillin; Vancomycin; Drug resistance; Mutation; Gene transfer; Geographical distribution DO - http://dx.doi.org/10.1128/AAC.44.5.1349-1351.2000 ER - TY - JOUR T1 - Illnesses Among United States Veterans of the Gulf War: A Population-Based Survey of 30,000 Veterans AN - 17531830; 4718500 AB - Despite numerous studies on veterans of the 1990 to 1991 Gulf War, the fundamental questions of how healthy they are and how their health compares with that of their military peers who were not deployed to the Gulf have not been fully answered. We conducted a health survey in which the health outcomes of a population-based sample of 15,000 Gulf veterans representing various military branches and unit components (regular, reserve, National Guard) were compared with those of 15,000 non-Gulf veterans who were randomly sampled to mirror the number in the same military strata in the Gulf veteran group. In comparison with their peers, Gulf veterans had a higher prevalence of functional impairment, health care utilization, symptoms, and medical conditions and a higher rate of low general health perceptions. A longitudinal follow-up of the health of these veterans will be needed to detect changes in health status and to detect diseases with a long latency period. JF - Journal of Occupational and Environmental Medicine AU - Kang, H K AU - Mahan, C M AU - Lee, KY AU - Magee, CA AU - Murphy, F M AD - Environmental Epidemiology Service, Department of Veterans Affairs, 1120 20th Street NW Suite 950, Washington, DC 20036, USA, han.kang@mail.va.gov Y1 - 2000/05// PY - 2000 DA - May 2000 VL - 42 IS - 5 SN - 1076-2752, 1076-2752 KW - Persian Gulf KW - USA KW - population studies KW - Health & Safety Science Abstracts KW - occupational diseases KW - Military KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17531830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Illnesses+Among+United+States+Veterans+of+the+Gulf+War%3A+A+Population-Based+Survey+of+30%2C000+Veterans&rft.au=Kang%2C+H+K%3BMahan%2C+C+M%3BLee%2C+KY%3BMagee%2C+CA%3BMurphy%2C+F+M&rft.aulast=Kang&rft.aufirst=H&rft.date=2000-05-01&rft.volume=42&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Military; Occupational health; occupational diseases ER - TY - JOUR T1 - Chemodenervation of the rat hemilarynx with phenol. AN - 85366398; pmid-10778888 AB - In this study, the injection of phenol into the true vocal fold was evaluated on a rat model as a possible treatment for adductor spasmodic dysphonia. A 10% phenol solution was injected into the right true vocal fold. Quantitative measurement of vocal fold adductory force showed reduction to 35% of the preinjection value 3 months after injection (p < .05). Qualitative evaluation by videolaryngoscopy demonstrated maintenance of the normal vocal fold range of motion. Histologic studies showed a transient inflammatory infiltrate and myolysis, while the vocal fold mucosa and the cricoarytenoid joints remained undamaged. Further investigation into the potential use of phenol for treating spasmodic dysphonia is warranted. JF - The Annals of otology, rhinology, and laryngology AU - Nguyen, T AU - Paniello, R C AD - Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, and the Veterans Administration Medical Center, St Louis, Missouri, USA. Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 355 EP - 359 VL - 109 IS - 4 SN - 0003-4894, 0003-4894 KW - National Library of Medicine KW - Rats KW - Laryngismus -- therapy KW - Animals KW - Rats, Sprague-Dawley KW - Laryngeal Muscles KW - Voice Disorders -- etiology KW - Laryngismus -- complications KW - Vagotomy KW - Laryngoscopy KW - Injections KW - Male KW - Voice Disorders -- therapy KW - Vocal Cords -- pathology KW - Vocal Cords -- physiology KW - Vocal Cords -- innervation KW - Phenol -- administration & dosage KW - Denervation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85366398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.atitle=Chemodenervation+of+the+rat+hemilarynx+with+phenol.&rft.au=Nguyen%2C+T%3BPaniello%2C+R+C&rft.aulast=Nguyen&rft.aufirst=T&rft.date=2000-04-01&rft.volume=109&rft.issue=4&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.issn=00034894&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - A multinational comparison of aphasia management practices. AN - 85345115; pmid-10912257 AB - The effect of restructuring of healthcare on the quality, quantity, and nature of aphasia management is largely unknown. The current study is the first to examine access, diagnostic, treatment, and discharge patterns of patients with aphasia in Australia, Canada, the UK, the US private sector (US-Private), and the US Veterans Health Administration in the Department of Veterans Affairs (US-VA). The authors developed a 37-item survey to be completed by clinicians working with aphasic patients. The survey focused on eight areas: access to care, evaluation procedures, group treatment, number and duration of treatment sessions, limitations of the number of sessions, termination of treatment, follow-up practices, and resumption of treatment. 394 surveys were distributed and 175 were returned completed (44% return rate). Respondents represented a range of ages, work experiences, and work settings. There was considerable consistency among respondents from our five healthcare systems. Results suggest that patients may be routinely denied treatment in direct contradiction to the research literature. Just as we carefully monitor the progress of patients receiving our treatment, we are obliged to monitor the effects of managed care on our patients, fellow clinicians, and our profession. JF - International journal of language & communication disorders / Royal College of Speech & Language Therapists AU - Katz, R C AU - Hallowell, B AU - Code, C AU - Armstrong, E AU - Roberts, P AU - Pound, C AU - Katz, L AD - Audiology and Speech Pathology Department (CS/126), Carl T. Hayden VA Medical Center, Phoenix, AZ 85012-1892, USA. richard.katz@med.va.gov Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 303 EP - 314 VL - 35 IS - 2 SN - 1368-2822, 1368-2822 KW - Index Medicus KW - National Library of Medicine KW - Canada -- epidemiology KW - Australia -- epidemiology KW - Aphasia -- epidemiology KW - Quality of Health Care KW - Humans KW - Health Services Accessibility -- standards KW - Treatment Outcome KW - Americas -- epidemiology KW - Great Britain -- epidemiology KW - Aphasia -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85345115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+language+%26+communication+disorders+%2F+Royal+College+of+Speech+%26+Language+Therapists&rft.atitle=A+multinational+comparison+of+aphasia+management+practices.&rft.au=Katz%2C+R+C%3BHallowell%2C+B%3BCode%2C+C%3BArmstrong%2C+E%3BRoberts%2C+P%3BPound%2C+C%3BKatz%2C+L&rft.aulast=Katz&rft.aufirst=R&rft.date=2000-04-01&rft.volume=35&rft.issue=2&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=International+journal+of+language+%26+communication+disorders+%2F+Royal+College+of+Speech+%26+Language+Therapists&rft.issn=13682822&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Health-related quality of life in Parkinson's disease after pallidotomy and deep brain stimulation. AN - 85343916; pmid-10753487 AB - This study explored the multidimensional outcome of three neurosurgical interventions for Parkinson's disease (PD): pallidotomy (N = 23), pallidal deep brain stimulation (DBS) (N = 9), and thalamic DBS (N = 7). All patients completed the Sickness Impact Profile (SIP) and the Beck Depression Inventory. Pallidotomy patients also completed the Profile of Mood States, the Beck Anxiety Inventory, and a disease-specific quality of life (QOL) measure, the Parkinson's Disease Questionnaire (PDQ-39). Three months after surgery, all neurosurgical groups showed significant improvements in mood and function, including physical, psychosocial, and overall functioning. Pallidal DBS and pallidotomy patients who completed additional QOL measures reported decreased anxiety and tension, increased vigor, improved mobility and ability to perform activities of daily living, and decreased perceived stigma. Psychosocial dysfunction scores from the SIP were related to depressed mood both at baseline (r = .42) and at followup (r = .45), but the physical dysfunction subscale was not related to mood at either time point, suggesting that disruption of social relationships due to PD may have more impact on affective distress than physical symptoms alone. Results suggest that neurosurgical interventions for PD improve disabling PD motor symptoms and also improve several domains of quality of life. Copyright 2000 Academic Press. JF - Brain and cognition AU - Straits-Tröster, K AU - Fields, J A AU - Wilkinson, S B AU - Pahwa, R AU - Lyons, K E AU - Koller, W C AU - Tröster, A I AD - Department of Veterans Affairs Medical Center, Kansas City, USA. troster@kansas-city.va.gov Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 399 EP - 416 VL - 42 IS - 3 SN - 0278-2626, 0278-2626 KW - Index Medicus KW - National Library of Medicine KW - Electric Stimulation -- methods KW - Anxiety -- psychology KW - Humans KW - Neurosurgical Procedures -- methods KW - Activities of Daily Living KW - Aged KW - Depression -- diagnosis KW - Globus Pallidus -- surgery KW - Globus Pallidus -- physiology KW - Brain -- physiology KW - Psychomotor Disorders -- diagnosis KW - Anxiety -- diagnosis KW - Depression -- psychology KW - Treatment Outcome KW - Middle Aged KW - Health Status KW - Quality of Life KW - Parkinson Disease -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85343916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+cognition&rft.atitle=Health-related+quality+of+life+in+Parkinson%27s+disease+after+pallidotomy+and+deep+brain+stimulation.&rft.au=Straits-Tr%C3%B6ster%2C+K%3BFields%2C+J+A%3BWilkinson%2C+S+B%3BPahwa%2C+R%3BLyons%2C+K+E%3BKoller%2C+W+C%3BTr%C3%B6ster%2C+A+I&rft.aulast=Straits-Tr%C3%B6ster&rft.aufirst=K&rft.date=2000-04-01&rft.volume=42&rft.issue=3&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Brain+and+cognition&rft.issn=02782626&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - The short- and long-term efficacy of empirical esophageal dilation in patients with nonobstructive dysphagia: a prospective, randomized study. AN - 85340474; pmid-10763936 AB - OBJECTIVE: The efficacy of empirical esophageal dilation for nonobstructive dysphagia (NOD) is unknown. Our aim was to assess the efficacy and safety of empirical dilation with a large bougie in patients with NOD. METHODS: Patients with NOD (normal barium swallow, free passage of a 13-mm barium pill, and normal esophagogastroduodenoscopy) were randomized to dilation with either a 50-Fr (Group A) or 26-Fr (Group B) Maloney dilator. Before dilation, the dysphagia (DyspSC) and diet (DietSc) scores were recorded and an esophageal manometry performed. Both scores were reassessed at 1, 3, 7, and 14 days after dilation. Success was defined at day 14 as an improvement in the DietSc of at least 25% from baseline, or a DyspSc of < or =3. Nonresponders were crossed-over to the alternate dilator and restudied. RESULTS: Twenty-three patients (58.7+/-1.9 yr) were enrolled: 13 in Group A and 10 in Group B. Both groups were matched for age, baseline DyspSc (4.2+/-0.6 vs 3.8+/-0.5), baseline DietSc (13.3+/-1.7 vs 12.0+/-1.9), and manometric findings. A nonspecific motility disorder was seen in 43.4% patients. Group A had an initial response rate significantly greater (84.6%) than Group B (40%) (p = 0.03; odds ratio [OR] = 8.25). The DyspSc and DietSc were better than baseline with both dilators, but only the DietSc improved significantly in patients dilated with the 50-Fr dilator (5.3+/-1.9 vs 12.3+/-1.4; p = 0.004). At 2 yr, 80% of the patients responding to the 50-Fr Maloney had a sustained response. CONCLUSION: Empirical dilation with a large (50-Fr) bougie is safe, effective, and long-lasting in improving nonobstructive dysphagia. JF - The American journal of gastroenterology AU - Colon, V J AU - Young, M A AU - Ramirez, F C AD - Department of Medicine, Carl T. Hayden Veterans Administration Medical Center, Phoenix, Arizona 85012, USA. Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 910 EP - 913 VL - 95 IS - 4 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Equipment Design KW - Deglutition Disorders -- therapy KW - Prospective Studies KW - Humans KW - Treatment Outcome KW - Follow-Up Studies KW - Middle Aged KW - Female KW - Male KW - Deglutition Disorders -- etiology KW - Dilatation -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85340474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=The+short-+and+long-term+efficacy+of+empirical+esophageal+dilation+in+patients+with+nonobstructive+dysphagia%3A+a+prospective%2C+randomized+study.&rft.au=Colon%2C+V+J%3BYoung%2C+M+A%3BRamirez%2C+F+C&rft.aulast=Colon&rft.aufirst=V&rft.date=2000-04-01&rft.volume=95&rft.issue=4&rft.spage=910&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - SuppNotes - Comment In: Am J Gastroenterol. 2001 Oct;96(10):3036[11693349] N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Changing strategies for treatment of systemic mycoses. AN - 72309677; 11012295 AB - There have been a number of changes in strategies in antifungal therapy in the past few years. AIDS related mycoses have decreased, and the increase of fluconazole resistant Candida albicans may be slowing because fewer severely immune depressed patients require constant fluconazole suppression. Candida species continue to be relatively common blood culture isolates. About half of these are C. albicans and half non-albicans species. In recent years, we have moved from the use of amphotericin B to fluconazole for initial treatment of candidemia. We have seen fluconazole resistant isolates emerge, primarily C. glabrata and a few C. krusei, but also C. albicans. It is unclear whether the increasing use of fluconazole in intensive care units will worsen this problem. There appears to be no advantage for the lipid formulations of amphotericin B, though they are useful to reduce or prevent renal toxicity. In the United States and Europe, prevention and treatment of aspergillosis have become increasingly important. There are increasing data suggesting that lipid formulations are more effective for both treatment and prevention of invasive disease in the most vulnerable patients with this infection. Renal toxicity is reduced but not avoided by use of the lipid formulations of amphotericin B. For those patients with less acutely progressing disease, the triazoles may be effective options. It is unclear at present whether itraconazole, voriconazole, or posaconazole will be the most favored drug. One promising new class, now in clinical trials, is the echinocandin group. Other agents, such as the sordarins, the chitin synthase inhibitors, and topoisomerase inhibitors, have promise but are much earlier in development. Unfortunately, we still have >50% treatment failure with acute invasive aspergillosis, and 20%-30% failures with candidemia. Now that we have multiple classes of antifungal drugs available, and others in preclinical trials, it would be advantageous to begin more active exploration of combination therapy with antifungals and with combined immune modulators and antifungals. JF - The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases AU - Graybill, J R AD - Department of Medicine, Veterans Administration Hospital, San Antonio, TX 78284, USA. Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 47 EP - 54 VL - 4 IS - 2 SN - 1413-8670, 1413-8670 KW - Antifungal Agents KW - 0 KW - Amphotericin B KW - 7XU7A7DROE KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Fluconazole KW - 8VZV102JFY KW - Index Medicus KW - AIDS/HIV KW - Fluconazole -- therapeutic use KW - Humans KW - Drug Resistance, Microbial KW - Granulocyte-Macrophage Colony-Stimulating Factor -- therapeutic use KW - Amphotericin B -- therapeutic use KW - Antifungal Agents -- therapeutic use KW - Mycoses -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72309677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Brazilian+journal+of+infectious+diseases+%3A+an+official+publication+of+the+Brazilian+Society+of+Infectious+Diseases&rft.atitle=Changing+strategies+for+treatment+of+systemic+mycoses.&rft.au=Graybill%2C+J+R&rft.aulast=Graybill&rft.aufirst=J&rft.date=2000-04-01&rft.volume=4&rft.issue=2&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=The+Brazilian+journal+of+infectious+diseases+%3A+an+official+publication+of+the+Brazilian+Society+of+Infectious+Diseases&rft.issn=14138670&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-28 N1 - Date created - 2000-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Efficacy of hydroquinone cream (USP 4%) used alone or in combination with salicylic acid peels in improving photodamage on the neck and upper chest. AN - 71059277; 10759820 AB - Salicylic acid, hydroquinone, and glycolic acid have been proved effective in the treatment of photodamaged facial skin. Few reports are available on the treatment of photodamage on the neck and upper chest. This study's purpose was to evaluate the efficacy of a cream containing 4% hydroquinone and 2% glycolic acid (LUSTRA) used alone or with salicylic acid peels in reversing actinic damage on the neck and upper chest. Nineteen women with moderate to advanced photodamage on the neck and upper chest applied a cream containing 4% hydroquinone and 2% glycolic acid twice daily on photodamaged areas for 12 weeks. Nine of these subjects had salicylic acid peels every 3 weeks. Improvements were assessed by the investigator, the subjects, and Mexameter readings measuring melanin and erythema levels. The result shows that there was a 33-71% improvement in photodamage, hyperpigmentation, texture, fine lines, dryness, tone, and clarity in both groups. There were no significant differences between the two treatments. Hydroquinone 4% cream with 2% glycolic acid is safe and effective in improving photodamage on the neck and upper chest when used alone or in combination with salicylic acid peels. JF - Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] AU - Gladstone, H B AU - Nguyen, S L AU - Williams, R AU - Ottomeyer, T AU - Wortzman, M AU - Jeffers, M AU - Moy, R L AD - Division of Dermatology, UCLA School of Medicine, and Veterans Administration, West Los AngelesMedical Center, Los Angeles, California, USA. Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 333 EP - 337 VL - 26 IS - 4 SN - 1076-0512, 1076-0512 KW - Glycolates KW - 0 KW - Hydroquinones KW - Keratolytic Agents KW - Ointments KW - glycolic acid KW - 0WT12SX38S KW - Monophenol Monooxygenase KW - EC 1.14.18.1 KW - Salicylic Acid KW - O414PZ4LPZ KW - hydroquinone KW - XV74C1N1AE KW - Index Medicus KW - Hyperpigmentation -- pathology KW - Hyperpigmentation -- therapy KW - Humans KW - Monophenol Monooxygenase -- antagonists & inhibitors KW - Glycolates -- administration & dosage KW - Female KW - Hydroquinones -- adverse effects KW - Thorax KW - Skin Aging -- drug effects KW - Hydroquinones -- administration & dosage KW - Neck KW - Chemexfoliation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71059277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dermatologic+surgery+%3A+official+publication+for+American+Society+for+Dermatologic+Surgery+%5Bet+al.%5D&rft.atitle=Efficacy+of+hydroquinone+cream+%28USP+4%25%29+used+alone+or+in+combination+with+salicylic+acid+peels+in+improving+photodamage+on+the+neck+and+upper+chest.&rft.au=Gladstone%2C+H+B%3BNguyen%2C+S+L%3BWilliams%2C+R%3BOttomeyer%2C+T%3BWortzman%2C+M%3BJeffers%2C+M%3BMoy%2C+R+L&rft.aulast=Gladstone&rft.aufirst=H&rft.date=2000-04-01&rft.volume=26&rft.issue=4&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Dermatologic+surgery+%3A+official+publication+for+American+Society+for+Dermatologic+Surgery+%5Bet+al.%5D&rft.issn=10760512&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-15 N1 - Date created - 2000-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epididymo-orchitis following intravesical bacillus Calmette-Guérin therapy. AN - 71046048; 10772435 AB - To describe a case of epididymo-orchitis that developed four years after treatment with intravesical bacillus Calmette-Guérin (BCG) and to review the incidence of this adverse effect. Information about the patient was obtained from the medical chart. A MEDLINE search of English-language literature (from January 1976 to April 1999) was conducted. All case reports of BCG-related epididymo-orchitis were evaluated. Review articles describing complications of BCG therapy for bladder cancer and the prevention and treatment of these complications were reviewed. Studies were evaluated for reports of BCG-related epididymo-orchitis and its treatment. Our case report is compared with others reported in the literature. The incidence of BCG-associated epididymoorchitis is rare. Epididymo-orchitis should be considered as a late complication of BCG therapy for bladder cancer. Proper patient selection may help decrease the risk of complications from BCG therapy. JF - The Annals of pharmacotherapy AU - Menke, J J AU - Heins, J R AD - South Dakota State University, Brookings, USA. Jennifer.menke@med.va.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 479 EP - 482 VL - 34 IS - 4 SN - 1060-0280, 1060-0280 KW - Adjuvants, Immunologic KW - 0 KW - BCG Vaccine KW - Index Medicus KW - Carcinoma, Transitional Cell -- complications KW - Humans KW - Urinary Bladder Neoplasms -- drug therapy KW - Incidence KW - Aged KW - Male KW - Carcinoma, Transitional Cell -- drug therapy KW - Administration, Intravesical KW - Urinary Bladder Neoplasms -- complications KW - Orchitis -- complications KW - BCG Vaccine -- therapeutic use KW - BCG Vaccine -- adverse effects KW - Orchitis -- epidemiology KW - Epididymitis -- complications KW - Adjuvants, Immunologic -- adverse effects KW - Orchitis -- chemically induced KW - Epididymitis -- epidemiology KW - Adjuvants, Immunologic -- therapeutic use KW - Epididymitis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71046048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Epididymo-orchitis+following+intravesical+bacillus+Calmette-Gu%C3%A9rin+therapy.&rft.au=Menke%2C+J+J%3BHeins%2C+J+R&rft.aulast=Menke&rft.aufirst=J&rft.date=2000-04-01&rft.volume=34&rft.issue=4&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-23 N1 - Date created - 2000-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Homocysteine. AN - 71043199; 10762063 AB - Homocysteine does not occur in the diet but it is an essential intermediate in normal mammalian metabolism of methionine. Each compound, methionine or homocysteine, is the precursor of the other. Similarly, the synthesis of one is the mechanism for the detoxification of the other. The ubiquitous methionine cycle is the metabolic basis for this relationship. In some tissues the transsulfuration pathway diverts homocysteine from the cycle and provides a means for the synthesis of cysteine and its derivatives. Methionine, (or homocysteine) metabolism is regulated by the disposition of homocysteine between these competing sequences. Both pathways require vitamin-derived cofactors, pyridoxine for transsulfuration and both folate and cobalamin in the methionine cycle. The clinical consequences of disruption of these pathways was apparent first in rare inborn errors of metabolism that cause homocystinuria, but recent studies focus on "hyperhomocysteinemia"--a lesser metabolic impairment that may result from genetic variations, acquired pathology, toxicity and nutritional inadequacy. Hyperhomocysteinemia is an independent risk factor for thrombovascular diseases however it is not clear whether the minimally increased concentration of the amino acid is the causative agent or merely a marker for the pathology. Until we resolve that question we cannot predict the potential efficacy of therapies based on folate administration with or without additional cobalamin and pyridoxine. JF - The international journal of biochemistry & cell biology AU - Finkelstein, J D AU - Martin, J J AD - VA Medical Center, Washington DC 20422, USA. James.finkelstein@med.va.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 385 EP - 389 VL - 32 IS - 4 SN - 1357-2725, 1357-2725 KW - Homocysteine KW - 0LVT1QZ0BA KW - Index Medicus KW - Animals KW - Humans KW - Homocysteine -- metabolism KW - Homocysteine -- deficiency KW - Homocysteine -- chemistry KW - Homocysteine -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71043199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+international+journal+of+biochemistry+%26+cell+biology&rft.atitle=Homocysteine.&rft.au=Finkelstein%2C+J+D%3BMartin%2C+J+J&rft.aulast=Finkelstein&rft.aufirst=J&rft.date=2000-04-01&rft.volume=32&rft.issue=4&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=The+international+journal+of+biochemistry+%26+cell+biology&rft.issn=13572725&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-19 N1 - Date created - 2000-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nefazodone treatment for chronic posttraumatic stress disorder: an open trial. AN - 71038628; 10770453 AB - Currently, there is no standard treatment for posttraumatic stress disorder (PTSD) because of a deficit of systematic treatment trials. The symptom overlap with other mood and anxiety disorders that respond to antidepressants and the results of a limited number of antidepressant trials indicate promise for psychopharmacologic treatment. Several open trials and one controlled trial with selective serotonin reuptake inhibitors have reported improvement in the symptomatology of PTSD. In this study, a relatively new serotonergic antidepressant, nefazodone, was tested as a treatment for PTSD. Veterans with chronic PTSD (N = 36) were enrolled in an 8-week open-label trial of nefazodone. The primary outcome measure was the Clinician-Administered PTSD Scale (CAPS). Thirty-one patients completed at least 4 weeks of treatment, which was considered to be an adequate trial, and 26 patients completed the 8-week study. During treatment, there was a significant decrease in the total CAPS score and in each of three CAPS subscale scores, with most of the improvement occurring during the first 4 weeks. Comparable improvements were also seen on the Hamilton Rating Scales for Anxiety and for Depression. Nefazodone treatment was well tolerated by this patient population, with only four patients discontinuing because of adverse effects. In summary, nefazodone treatment improved the symptoms of PTSD, including the core symptoms. Placebo-controlled studies should be undertaken to further elucidate the efficacy of nefazodone in the treatment of PTSD. JF - Journal of clinical psychopharmacology AU - Davis, L L AU - Nugent, A L AU - Murray, J AU - Kramer, G L AU - Petty, F AD - Department of Veterans Affairs Medical Center at Tuscaloosa, Alabama 35404, USA. Davis.Lori@Tuscaloosa.va.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 159 EP - 164 VL - 20 IS - 2 SN - 0271-0749, 0271-0749 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Triazoles KW - nefazodone KW - 59H4FCV1TF KW - Index Medicus KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Personality Inventory KW - Middle Aged KW - Chronic Disease KW - Male KW - Female KW - Combat Disorders -- psychology KW - Antidepressive Agents, Second-Generation -- adverse effects KW - Antidepressive Agents, Second-Generation -- therapeutic use KW - Stress Disorders, Post-Traumatic -- psychology KW - Combat Disorders -- drug therapy KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Veterans -- psychology KW - Combat Disorders -- diagnosis KW - Triazoles -- therapeutic use KW - Triazoles -- adverse effects KW - Stress Disorders, Post-Traumatic -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71038628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Nefazodone+treatment+for+chronic+posttraumatic+stress+disorder%3A+an+open+trial.&rft.au=Davis%2C+L+L%3BNugent%2C+A+L%3BMurray%2C+J%3BKramer%2C+G+L%3BPetty%2C+F&rft.aulast=Davis&rft.aufirst=L&rft.date=2000-04-01&rft.volume=20&rft.issue=2&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-28 N1 - Date created - 2000-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. AN - 71035483; 10735785 AB - We tested the hypothesis that L-arginine (the substrate for nitric oxide production)-combined with amrinone, milrinone (Type III phosphodiesterase [PDE] inhibitors), zaprinast, or sildenafil (Type V PDE inhibitors)-would vasodilate synergistically. Internal mammary artery segments were excised from anesthetized swine, divided into rings, and suspended in a tissue bath at 37 degrees C. Force of contraction was measured during dose-response testing of combinations of L-arginine and amrinone, milrinone, zaprinast, or sildenafil. Amrinone and milrinone were additive to L-arginine. N(G)-methyl-L-arginine (L-NMA) inhibited the effects of milrinone but not amrinone. The effective concentration of amrinone eliciting 50% relaxation (EC(50)) was 3.8E-05M (n = 6) when given alone and 4. 4E-05M (n = 6) with L-NMA. Milrinone had EC(50) = 6.0E-06M alone (n = 6) and 2.8E-05M (n = 6) with L-NMA. Zaprinast (EC(50) = 6.5E-05M, n = 6) and sildenafil (EC(30) = 1.8E-05M, n = 6) were synergistic with L-arginine. L-NMA blocked their effects, increasing the EC(50) for zaprinast to 9.9E-03M and the EC(30) for sildenafil to 6.1E+02M. In conclusion, L-arginine is additive to the vasodilation of the type III PDE inhibitors, amrinone and milrinone, but synergistic with the type V PDE inhibitors, zaprinast and sildenafil. Amrinone and milrinone, Type III cAMP-dependent phosphodiesterase inhibitors, are additive to L-arginine-dependent vasodilation. Zaprinast and sildenafil, Type V cGMP-dependent phosphodiesterase inhibitors, are synergistic with L-arginine. JF - Anesthesia and analgesia AU - Wallace, A W AU - Tom, W L AD - Department of Anesthesiology, San Francisco Veterans Administration Medical Center and Department of Anesthesiology, University of California-San Francisco, San Francisco, California, USA. awallace@best.com Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 840 EP - 846 VL - 90 IS - 4 SN - 0003-2999, 0003-2999 KW - Phosphodiesterase Inhibitors KW - 0 KW - omega-N-Methylarginine KW - 27JT06E6GR KW - Arginine KW - 94ZLA3W45F KW - Cyclic GMP KW - H2D2X058MU KW - Abridged Index Medicus KW - Index Medicus KW - Swine KW - Animals KW - Dose-Response Relationship, Drug KW - Cyclic GMP -- physiology KW - omega-N-Methylarginine -- pharmacology KW - Drug Synergism KW - Phosphodiesterase Inhibitors -- pharmacology KW - Mammary Arteries -- drug effects KW - Vasodilation -- drug effects KW - Mammary Arteries -- physiology KW - Arginine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71035483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Interaction+of+L-arginine+and+phosphodiesterase+inhibitors+in+vasodilation+of+the+porcine+internal+mammary+artery.&rft.au=Wallace%2C+A+W%3BTom%2C+W+L&rft.aulast=Wallace&rft.aufirst=A&rft.date=2000-04-01&rft.volume=90&rft.issue=4&rft.spage=840&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=00032999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-20 N1 - Date created - 2000-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pediatric immunization for the future. Lyme disease vaccine and beyond. AN - 71031278; 10761515 AB - This article highlights some of the exciting new developments in pediatric immunization. Starting with the newly licensed Lyme disease vaccine, which is not yet approved for children younger than 15 years of age, the article discusses potential vaccines for severe allergy and cocaine abuse and stresses some of the new techniques in needleless vaccination, including the edible plant technology. JF - Pediatric clinics of North America AU - Lutwick, L I AU - Abramson, J M AD - Department of Medicine, Veterans Affairs New York Harbor Health Care System, Brooklyn, USA. larry.lutwick@med.va.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 465 EP - 79, viii VL - 47 IS - 2 SN - 0031-3955, 0031-3955 KW - Viral Vaccines KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Plants, Genetically Modified KW - Immunotherapy KW - Humans KW - Hypersensitivity -- prevention & control KW - Forecasting KW - Child KW - Ixodes -- drug effects KW - Cocaine-Related Disorders -- prevention & control KW - Cocaine-Related Disorders -- immunology KW - Vaccination -- trends KW - Lyme Disease -- diagnosis KW - Lyme Disease -- prevention & control KW - Viral Vaccines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71031278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+clinics+of+North+America&rft.atitle=Pediatric+immunization+for+the+future.+Lyme+disease+vaccine+and+beyond.&rft.au=Lutwick%2C+L+I%3BAbramson%2C+J+M&rft.aulast=Lutwick&rft.aufirst=L&rft.date=2000-04-01&rft.volume=47&rft.issue=2&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Pediatric+clinics+of+North+America&rft.issn=00313955&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-26 N1 - Date created - 2000-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Therapeutic limit setting in an assertive community treatment program. AN - 71001770; 10737826 AB - The study examined the use of therapeutic limit-setting activities by members of assertive community treatment teams with clients who had serious mental illness. Case managers from 40 Veterans Affairs intensive psychiatric community care teams reported their use of 25 limit-setting activities with 1,564 veterans during the first six months of treatment. The 25-item measurement scale was factor analyzed, and a standard multiple regression procedure was used to regress scale scores on clients' characteristics, the frequency of case managers' contact with service providers and others, and clients' and case managers' perceptions about the therapeutic alliance. Case managers relied most frequently on informal verbal approaches to limit setting and relied least on formal legal restrictions. Factor analysis of the instrument, the Therapeutic Limit Setting (TLS) scale, reduced the number of items to 20 and resulted in a five-factor solution. The limit-setting factors were verbal guidance, money management, contingent withholding of services or support, enforced hospitalization, and invocation of external authorities. The TLS and its subscales were characterized by high internal consistency, modest intercorrelation, and unique relationships with variables related to clients' characteristics, the treatment process, and the therapeutic alliance. Case managers were more likely to set limits with clients who had more extensive hospitalization histories, a representative payee, recent alcohol or drug use, more arrests, and more severe symptoms. Case managers used a range of limit-setting strategies in assertive community treatment. Limit setting is a frequent and potentially important aspect of assertive community treatment that may be useful for comparing levels of assertiveness in assertive community treatment teams and other community-based rehabilitation services. JF - Psychiatric services (Washington, D.C.) AU - Neale, M S AU - Rosenheck, R A AD - Veterans Affairs Northeast Program Evaluation Center, VA Connecticut Healthcare System, Campbell Avenue, West Haven, Connecticut, 06156, USA. michael.neale@med.va.gov Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 499 EP - 505 VL - 51 IS - 4 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - Patient Care Team KW - Humans KW - Treatment Outcome KW - Diagnosis, Dual (Psychiatry) KW - Social Support KW - Middle Aged KW - Case Management KW - Professional-Patient Relations KW - Male KW - Female KW - Substance-Related Disorders -- diagnosis KW - Psychotic Disorders -- psychology KW - Behavior Therapy KW - Veterans -- psychology KW - Psychotic Disorders -- rehabilitation KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Psychotic Disorders -- diagnosis KW - Community Mental Health Services KW - Assertiveness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71001770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Therapeutic+limit+setting+in+an+assertive+community+treatment+program.&rft.au=Neale%2C+M+S%3BRosenheck%2C+R+A&rft.aulast=Neale&rft.aufirst=M&rft.date=2000-04-01&rft.volume=51&rft.issue=4&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-27 N1 - Date created - 2000-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of ammonia on GABA uptake and release in cultured astrocytes. AN - 70987238; 10733006 AB - While the pathogenesis of hepatic encephalopathy (HE) is unclear, there is evidence of enhanced GABAergic neurotransmission in this condition. Ammonia is believed to play a major pathogenetic role in HE. To determine whether ammonia might contribute to abnormalities in GABAergic neurotransmission, its effects on GABA uptake and release were studied in cultured astrocytes, cells that appear to be targets of ammonia neurotoxicity. Acutely, ammonium chloride (5 mM) inhibited GABA uptake by 30%, and by 50-60% after 4-day treatment. GABA uptake inhibition was associated with a predominant decrease in Vmax; the Km was also decreased. Ammonia also enhanced GABA release after 4-day treatment, although such release was initially inhibited. These effects of ammonia (inhibition of GABA uptake and enhanced GABA release) may elevate extracellular levels of GABA and contribute to a dysfunction of GABAergic neurotransmission in HE and other hyperammonemic states. JF - Neurochemistry international AU - Bender, A S AU - Norenberg, M D AD - Veterans Administration Medical Center and Department of Pathology, University of Miami School of Medicine, FL 33101, USA. Y1 - 2000/04// PY - 2000 DA - April 2000 SP - 389 EP - 395 VL - 36 IS - 4-5 SN - 0197-0186, 0197-0186 KW - GABA Antagonists KW - 0 KW - Ammonium Chloride KW - 01Q9PC255D KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Ammonia KW - 7664-41-7 KW - Index Medicus KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Kinetics KW - GABA Antagonists -- pharmacology KW - Ammonium Chloride -- pharmacology KW - Time Factors KW - Ammonia -- pharmacology KW - Astrocytes -- drug effects KW - gamma-Aminobutyric Acid -- metabolism KW - Astrocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70987238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=Effect+of+ammonia+on+GABA+uptake+and+release+in+cultured+astrocytes.&rft.au=Bender%2C+A+S%3BNorenberg%2C+M+D&rft.aulast=Bender&rft.aufirst=A&rft.date=2000-04-01&rft.volume=36&rft.issue=4-5&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=01970186&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-10 N1 - Date created - 2000-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of patient self-reports and urinalysis results obtained under naturalistic methadone treatment conditions. AN - 70956209; 10706974 AB - This study examined under naturalistic assessment conditions the validity of self-reported opiate and cocaine use among 175 veterans enrolled in methadone treatment, and factors related to self-report validity, such as stage in treatment and drug of abuse. Veterans were interviewed by clinical staff about past 30-day drug use with the addiction severity index (ASI), and urinalysis results were obtained for the same 30-day interval assessed with the ASI. Analysis revealed that urinalysis generally produced higher rates of substance use than patient self-report, and with the exception of reported opiate use among new patients presenting for treatment, validity of patient self-reported drug use generally was poor with patients under-reporting both opiate and cocaine use. The findings are in marked contrast to those obtained in other studies in which participants are ensured confidentiality regarding their self-reports. Further, the results raise questions about the utility of self-report measures of substance use to assess patient progress or methadone program performance. JF - Drug and alcohol dependence AU - Chermack, S T AU - Roll, J AU - Reilly, M AU - Davis, L AU - Kilaru, U AU - Grabowski, J AD - John D. Dingell VA Medical Center, Department of Psychiatry (116A), 4646 John R. Street, Detroit, MI 48201-1932, USA. chermack.stephen@med.va.gov Y1 - 2000/04/01/ PY - 2000 DA - 2000 Apr 01 SP - 43 EP - 49 VL - 59 IS - 1 SN - 0376-8716, 0376-8716 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Methadone -- therapeutic use KW - Reproducibility of Results KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Opioid-Related Disorders -- psychology KW - Patient Compliance -- psychology KW - Cocaine-Related Disorders -- psychology KW - Veterans -- psychology KW - Substance Abuse Detection -- psychology KW - Opioid-Related Disorders -- rehabilitation KW - Truth Disclosure KW - Cocaine-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70956209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Comparison+of+patient+self-reports+and+urinalysis+results+obtained+under+naturalistic+methadone+treatment+conditions.&rft.au=Chermack%2C+S+T%3BRoll%2C+J%3BReilly%2C+M%3BDavis%2C+L%3BKilaru%2C+U%3BGrabowski%2C+J&rft.aulast=Chermack&rft.aufirst=S&rft.date=2000-04-01&rft.volume=59&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-03 N1 - Date created - 2000-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Levofloxacin penetrates human monocytes and enhances intracellular killing of Staphylococcus aureus and Pseudomonas aeruginosa AN - 17562621; 4742266 AB - Intracellular bacteria often cause relapsing and refractory infections. However, these infections can be treated effectively with antibiotics such as ofloxacin which penetrate into the cells containing bacteria. As levofloxacin, the levorotatory isomer of ofloxacin, has enhanced antibacterial activity, we tested the levofloxacin concentration in human monocytes and the effects of intracellular levofloxacin on monocyte killing of Staphylococcus aureus strain ATCC 29213 and Pseudomonas aeruginosa strain PA1348A. Human monocytes were incubated with levofloxacin at various pH values and temperatures. Following incubation, the monocytes were separated from incubation media, and intracellular (C) and extracellular (E) levofloxacin concentrations were determined. Mean C/E ratios after 15 min of incubation with 6 and 12 mg/L levofloxacin at pH 7.4 were 6.4 and 7.1, respectively. C/E ratios were similar at pH 7.4 and 8.0, but decreased at lower pH values. To study the effects of levofloxacin on intracellular killing of S. aureus and P. aeruginosa, opsonized bacteria were added to monolayers of monocytes. Following phagocytosis, monocytes were incubated with various concentrations of levofloxacin, ciprofloxacin and rifampicin, alone or in combination. Levofloxacin (2.5 and 4 mg/L) significantly reduced the survival of cell-associated S. aureus and was more effective than ciprofloxacin at similar concentrations (P < 0.01). Enhanced killing of cell-associated P. aeruginosa by levofloxacin (0.5 and 1.0 mg/L) was also observed. Activities of levofloxacin and ciprofloxacin against cell-associated P. aeruginosa were similar. Addition of rifampicin did not augment the bactericidal activity of levofloxacin. Since levofloxacin is concentrated in human monocytes and increases their bactericidal activity against intracellular bacteria, it should be considered for treatment of infections caused by susceptible intracellular bacteria. JF - Journal of Antimicrobial Chemotherapy AU - Smith, R P AU - Baltch, AL AU - Franke, MA AU - Michelsen, P B AU - Bopp, L H AD - Infectious Disease Section, Stratton VA Medical Center, 113 Holland Avenue, Albany, NY 12208, USA, smith.raymond@albany.va.gov Y1 - 2000/04// PY - 2000 DA - Apr 2000 SP - 483 EP - 488 VL - 45 IS - 4 SN - 0305-7453, 0305-7453 KW - intercellular killing KW - in vitro KW - man KW - levofloxacin KW - quinolones KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Monocytes KW - quinolines KW - Antibacterial agents KW - Pseudomonas aeruginosa KW - Staphylococcus aureus KW - J 02806:Quinones, quinolones and quinolines KW - A 01066:Antibacterial & bactericidal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17562621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Levofloxacin+penetrates+human+monocytes+and+enhances+intracellular+killing+of+Staphylococcus+aureus+and+Pseudomonas+aeruginosa&rft.au=Smith%2C+R+P%3BBaltch%2C+AL%3BFranke%2C+MA%3BMichelsen%2C+P+B%3BBopp%2C+L+H&rft.aulast=Smith&rft.aufirst=R&rft.date=2000-04-01&rft.volume=45&rft.issue=4&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Staphylococcus aureus; Pseudomonas aeruginosa; Antibacterial agents; quinolines; levofloxacin; Monocytes ER - TY - JOUR T1 - Effects of mutations in M4 of the gastric H+,K+-ATPase on inhibition kinetics of SCH28080. AN - 70986600; 10715120 AB - The effects of site-directed mutagenesis were used to explore the role of residues in M4 on the apparent Ki of a selective, K+-competitive inhibitor of the gastric H+,K+ ATPase, SCH28080. A double transfection expression system is described, utilizing HEK293 cells and separate plasmids encoding the alpha and beta subunits of the H+,K+-ATPase. The wild-type enzyme gave specific activity (micromoles of Pi per hour per milligram of expressed H+,K+-ATPase protein), apparent Km for ammonium (a K+ surrogate), and apparent Ki for SCH28080 equal to the H+, K+-ATPase purified from hog gastric mucosa. Amino acids in the M4 transmembrane segment of the alpha subunit were selected from, and substituted with, the nonconserved residues in M4 of the Na+, K+-ATPase, which is insensitive to SCH28080. Most of the mutations produced competent enzyme with similar Km,app values for NH4+ and Ki,app for SCH28080. SCH28080 affinity was decreased 2-fold in M330V and 9-fold in both M334I and V337I without significant effect on Km,app. Hence methionine 334 and valine 337 participate in binding but are not part of the NH4+ site. Methionine 330 may be at the periphery of the inhibitor site, which must have minimum dimensions of approximately 16 x 8 x 5 A and be accessible from the lumen in the E2-P conformation. Multiple sequence alignments place the membrane surface near arginine 328, suggesting that the side chains of methionine 334 and valine 337, on one side of the M4 helix, project into a binding cavity within the membrane domain. JF - Biochemistry AU - Munson, K B AU - Lambrecht, N AU - Sachs, G AD - Veterans' Administration Greater Los Angeles Healthcare System and Univeristy of California-Los Angeles Department of Medicine & Physiology, Los Angeles, California 90024, USA. Y1 - 2000/03/21/ PY - 2000 DA - 2000 Mar 21 SP - 2997 EP - 3004 VL - 39 IS - 11 SN - 0006-2960, 0006-2960 KW - Cations, Monovalent KW - 0 KW - Enzyme Inhibitors KW - Imidazoles KW - Proton Pump Inhibitors KW - Quaternary Ammonium Compounds KW - Sch 28080 KW - 00427X161I KW - H(+)-K(+)-Exchanging ATPase KW - EC 3.6.3.10 KW - Index Medicus KW - Animals KW - Cell Membrane -- enzymology KW - Cell Membrane -- drug effects KW - Humans KW - Cell Membrane -- genetics KW - Rabbits KW - Amino Acid Sequence KW - Cations, Monovalent -- metabolism KW - Enzyme Activation -- genetics KW - Blotting, Western KW - Kinetics KW - Binding Sites -- drug effects KW - Molecular Sequence Data KW - Enzyme Activation -- drug effects KW - Binding Sites -- genetics KW - Quaternary Ammonium Compounds -- pharmacology KW - Stomach -- enzymology KW - Cell Line KW - Mutagenesis, Site-Directed KW - Imidazoles -- metabolism KW - H(+)-K(+)-Exchanging ATPase -- metabolism KW - Enzyme Inhibitors -- chemistry KW - Enzyme Inhibitors -- metabolism KW - H(+)-K(+)-Exchanging ATPase -- chemistry KW - H(+)-K(+)-Exchanging ATPase -- genetics KW - Imidazoles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70986600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Effects+of+mutations+in+M4+of+the+gastric+H%2B%2CK%2B-ATPase+on+inhibition+kinetics+of+SCH28080.&rft.au=Munson%2C+K+B%3BLambrecht%2C+N%3BSachs%2C+G&rft.aulast=Munson&rft.aufirst=K&rft.date=2000-03-21&rft.volume=39&rft.issue=11&rft.spage=2997&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-14 N1 - Date created - 2000-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The human papillomavirus type 11 E1E4 protein is phosphorylated in genital epithelium. AN - 70954587; 10704351 AB - The most abundant viral transcript in human papillomavirus (HPV) 11-infected xenograft tissue has been shown to encode the E1(wedge)E4 protein. The function of E1(wedge)E4 protein has not been determined. Several potential phosphorylation sequence motifs were identified in the HPV 11 E1(wedge)E4 protein, including potential sites of phosphorylation by mitogen-activated protein kinase (MAPK), cAMP-dependent protein kinase (PKA), casein kinase II, and protein kinase C. To test phosphorylation of the HPV 11 E1(wedge)E4 protein, a soluble maltose binding protein (MBP) fusion was produced in Escherichia coli. Only MAPK and PKA phosphorylated the E1(wedge)E4 protein. Phosphoamino acid analysis showed that one or more threonine residues were phosphorylated by MAPK, and both serine and threonine residues were phosphorylated by PKA. MBP-E1(wedge)E4 mutant proteins were designed to delineate the E1(wedge)E4 phosphoacceptor residues. MAPK was shown to phosphorylate E1(wedge)E4 on threonine 53 within a MAPK consensus phorphorylation sequence motif. PKA was shown to phosphorylate E1(wedge)E4 at two residues: threonine 36 within a consensus motif and serine 44 within a variant of the PKA consensus phosphorylation sequence motif. HPV 11-infected human genital tissue grown as a xenograft in an athymic mouse was labeled with [(32)P]orthophosphate. Phosphoamino acid analysis of E1(wedge)E4 protein immunoprecipitated from (32)P-labeled tissue revealed that both serine and threonine residues were phosphorylated. Analysis by liquid chromatography-mass spectrophotometry was consistent with phosphorylation of residues within the PKA and MAPK phosphorylation sequence motifs. Expression of E1(wedge)E4 protein containing phosphorylation substitution mutations showed that the PKA mutant did not differ from wild-type E1(wedge)E4 protein in intracellular distribution. In contrast, the MAPK mutant did not localize exclusively to the cytoplasm nor did it colocalize with wild-type E1(wedge)E4 protein. We conclude that HPV 11 E1(wedge)E4 protein is phosphorylated in vitro and in vivo. Our data are consistent with phosphorylation of HPV 11 E1(wedge)E4 protein by MAPK and PKA in infected tissue. Copyright 2000 Academic Press. JF - Virology AU - Bryan, J T AU - Han, A AU - Fife, K H AU - Brown, D R AD - Department of Medicine, Roudebush Veterans Administration Hospital, Indianapolis, Indiana, 46202, USA. Y1 - 2000/03/15/ PY - 2000 DA - 2000 Mar 15 SP - 430 EP - 439 VL - 268 IS - 2 SN - 0042-6822, 0042-6822 KW - DNA-Binding Proteins KW - 0 KW - E1 protein, Human papillomavirus type 11 KW - Oncogene Proteins, Fusion KW - Oncogene Proteins, Viral KW - Viral Proteins KW - oncogene protein E4, type 11, Human papillomavirus KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - PTPRU protein, human KW - EC 3.1.3.48 KW - Protein Tyrosine Phosphatases KW - Ptpru protein, mouse KW - Receptor-Like Protein Tyrosine Phosphatases, Class 2 KW - Index Medicus KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - Mass Spectrometry KW - Animals KW - Protein Tyrosine Phosphatases -- metabolism KW - Mitogen-Activated Protein Kinases -- metabolism KW - Humans KW - Epithelium -- enzymology KW - Mice, Nude KW - Mice KW - Amino Acid Sequence KW - Mutagenesis, Site-Directed KW - Epithelium -- virology KW - Phosphorylation KW - Epithelium -- transplantation KW - Keratinocytes -- enzymology KW - Molecular Sequence Data KW - Chromatography, Liquid KW - Transplantation, Heterologous KW - Epithelium -- metabolism KW - Keratinocytes -- metabolism KW - Keratinocytes -- virology KW - Viral Proteins -- genetics KW - Genitalia -- virology KW - DNA-Binding Proteins -- biosynthesis KW - DNA-Binding Proteins -- genetics KW - Viral Proteins -- biosynthesis KW - Papillomaviridae -- genetics KW - Oncogene Proteins, Fusion -- biosynthesis KW - Oncogene Proteins, Viral -- metabolism KW - Oncogene Proteins, Fusion -- genetics KW - Viral Proteins -- metabolism KW - Oncogene Proteins, Viral -- genetics KW - Papillomaviridae -- enzymology KW - Oncogene Proteins, Fusion -- metabolism KW - Oncogene Proteins, Viral -- biosynthesis KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70954587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=The+human+papillomavirus+type+11+E1E4+protein+is+phosphorylated+in+genital+epithelium.&rft.au=Bryan%2C+J+T%3BHan%2C+A%3BFife%2C+K+H%3BBrown%2C+D+R&rft.aulast=Bryan&rft.aufirst=J&rft.date=2000-03-15&rft.volume=268&rft.issue=2&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-18 N1 - Date created - 2000-04-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. AN - 70939375; 10702247 AB - Ceramide is not only a core intermediate of sphingolipids but also an important modulator of many cellular events including apoptosis, cell cycle arrest, senescence, differentiation, and stress responses. Its turnover may be tightly regulated. However, little is known about the regulation of its metabolism because most enzymes responsible for its synthesis and breakdown have yet to be cloned. Here we report the cloning and characterization of the yeast gene YPC1 (YBR183w) by screening Saccharomyces cerevisiae genes whose overexpression bestows resistance to fumonisin B1. We demonstrate that the yeast gene YPC1 encodes an alkaline ceramidase activity responsible for the breakdown of dihydroceramide and phytoceramide but not unsaturated ceramide. YPC1 ceramidase activity was confirmed by in vitro studies using an Escherichia coli expression system. Importantly, YPC1p also has reverse activity, catalyzing synthesis of phytoceramide from palmitic acid and phytosphingosine. This ceramide synthase activity is CoA-independent and is resistant to fumonisin B1, thus explaining why YPC1 was cloned as a fumonisin B1-resistant gene. JF - The Journal of biological chemistry AU - Mao, C AU - Xu, R AU - Bielawska, A AU - Obeid, L M AD - Division of General Internal Medicine at the Ralph H. Johnson Veterans Administration Hospital and the Departments of Medicine, Charleston, South Carolina 29425, USA. Y1 - 2000/03/10/ PY - 2000 DA - 2000 Mar 10 SP - 6876 EP - 6884 VL - 275 IS - 10 SN - 0021-9258, 0021-9258 KW - Carboxylic Acids KW - 0 KW - Fumonisins KW - Sphingolipids KW - fumonisin B1 KW - 3ZZM97XZ32 KW - Oxidoreductases KW - EC 1.- KW - dihydroceramide desaturase KW - EC 1.3.1.- KW - Amidohydrolases KW - EC 3.5.- KW - Ceramidases KW - EC 3.5.1.23 KW - Index Medicus KW - Base Sequence KW - Genes, Fungal KW - Hydrogen-Ion Concentration KW - Molecular Sequence Data KW - Carboxylic Acids -- pharmacology KW - Escherichia coli -- genetics KW - Sphingolipids -- metabolism KW - Cloning, Molecular KW - Saccharomyces cerevisiae -- genetics KW - Oxidoreductases -- genetics KW - Amidohydrolases -- genetics KW - Saccharomyces cerevisiae -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70939375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Cloning+of+an+alkaline+ceramidase+from+Saccharomyces+cerevisiae.+An+enzyme+with+reverse+%28CoA-independent%29+ceramide+synthase+activity.&rft.au=Mao%2C+C%3BXu%2C+R%3BBielawska%2C+A%3BObeid%2C+L+M&rft.aulast=Mao&rft.aufirst=C&rft.date=2000-03-10&rft.volume=275&rft.issue=10&rft.spage=6876&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-03 N1 - Date created - 2000-04-03 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - AF191745; GENBANK N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Leiomyoma of the trachea: a case report and a novel surgical approach. AN - 85343582; pmid-10758998 JF - American journal of otolaryngology AU - Borski, T G AU - Stucker, F J AU - Grafton, W D AU - Nathan, C A AD - Department of Otolaryngology/Head & Neck Surgery, Louisiana State University Medical Center and Veterans Administration, Shreveport 71130, USA. Y1 - 2000/03// PY - 2000 DA - Mar 2000 SP - 119 EP - 121 VL - 21 IS - 2 SN - 0196-0709, 0196-0709 KW - Index Medicus KW - National Library of Medicine KW - Magnetic Resonance Imaging KW - Bronchoscopy KW - Humans KW - Adult KW - Treatment Outcome KW - Follow-Up Studies KW - Female KW - Pulmonary Surgical Procedures KW - Leiomyoma -- surgery KW - Leiomyoma -- pathology KW - Tracheal Neoplasms -- pathology KW - Tracheal Neoplasms -- surgery KW - Tracheal Neoplasms -- diagnosis KW - Leiomyoma -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85343582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+otolaryngology&rft.atitle=Leiomyoma+of+the+trachea%3A+a+case+report+and+a+novel+surgical+approach.&rft.au=Borski%2C+T+G%3BStucker%2C+F+J%3BGrafton%2C+W+D%3BNathan%2C+C+A&rft.aulast=Borski&rft.aufirst=T&rft.date=2000-03-01&rft.volume=21&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=American+journal+of+otolaryngology&rft.issn=01960709&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Levodopa therapy and the risk of malignant melanoma. AN - 71284458; 10917387 AB - To evaluate the use of levodopa therapy in patients with Parkinson's disease and malignant melanoma. A MEDLINE search (January 1966-September 1999) of English-language articles was conducted. Key search terms included levodopa, melanoma, and Parkinson's disease; 34 case reports were identified. Carbidopa/levodopa continues to be a mainstay in the treatment of Parkinson's disease. Since the late 1970s, a warning has appeared in the prescribing literature for levodopa regarding the risk of activating malignant melanoma. An evaluation was conducted of the case reports in which a causal relationship between levodopa and melanoma was suggested. There is an unlikely association between levodopa and induction or exacerbation of malignant melanoma. JF - The Annals of pharmacotherapy AU - Siple, J F AU - Schneider, D C AU - Wanlass, W A AU - Rosenblatt, B K AD - Pharmacy Service, Veterans Affairs Medical Center, Portland, OR 97207, USA. siple.jolene@portland.va.gov Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 382 EP - 385 VL - 34 IS - 3 SN - 1060-0280, 1060-0280 KW - Antiparkinson Agents KW - 0 KW - Levodopa KW - 46627O600J KW - Index Medicus KW - Parkinson Disease -- etiology KW - Humans KW - Parkinson Disease -- complications KW - Antiparkinson Agents -- adverse effects KW - Melanoma -- chemically induced KW - Levodopa -- therapeutic use KW - Antiparkinson Agents -- therapeutic use KW - Levodopa -- adverse effects KW - Melanoma -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71284458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Levodopa+therapy+and+the+risk+of+malignant+melanoma.&rft.au=Siple%2C+J+F%3BSchneider%2C+D+C%3BWanlass%2C+W+A%3BRosenblatt%2C+B+K&rft.aulast=Siple&rft.aufirst=J&rft.date=2000-03-01&rft.volume=34&rft.issue=3&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinicopathological features of aggressive large granular lymphocyte leukaemia resemble Fas ligand transgenic mice. AN - 71117994; 10792274 AB - Fas ligand triggers cell death after interaction with its receptor Fas. Altered expression of Fas has been associated with lymphoproliferation and autoimmune disorders in both mice and man. Apoptosis of lung and liver tissue is seen in Fas ligand transgenic mice. It is not known whether constitutive expression of Fas ligand can cause a similar human disease. Four patients with aggressive large granular lymphocyte (LGL) leukaemia involving lung and liver were studied. All four patients were severely ill with pulmonary involvement. Two patients presented with hypoxia and were oxygen dependent; the other two patients had severe pulmonary hypertension. Lung biopsies showed interstitial infiltration by leukaemic LGL. The infiltrating lymphocytes expressed both Fas and Fas ligand, whereas normal pneumocytes expressed only Fas. Similar findings were observed in liver biopsies from these patients. Features mimicking the pathological changes of graft-versus-host disease were observed, including pneumocyte apoptosis. All four patients had high levels of circulating Fas ligand. Successful treatment with oral methotrexate or 2-chlorodeoxyadenosine was associated with disappearance or marked reduction of circulating Fas ligand. These results suggest that dysregulated expression of Fas ligand can lead to human disease with pathological features resembling graft-versus-host disease. JF - British journal of haematology AU - Lamy, T AU - Bauer, F A AU - Liu, J H AU - Li, Y X AU - Pillemer, E AU - Shahidi, H AU - Gregory, S A AU - Zambello, R AU - Marcolongo, R AU - Semenzato, G AU - Loughran, T P AD - H. Lee Moffitt Cancer Center and Research Institute, The Veterans' Administration Hospital, and the Department of Medicine and Microbiology/Immunology, University of South Florida Medical School, Tampa, FL, USA. Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 717 EP - 723 VL - 108 IS - 4 SN - 0007-1048, 0007-1048 KW - Antigens, CD95 KW - 0 KW - Antimetabolites, Antineoplastic KW - FASLG protein, human KW - Fas Ligand Protein KW - Fasl protein, mouse KW - Membrane Glycoproteins KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Animals KW - Apoptosis KW - Humans KW - Gene Expression KW - Mice KW - Mice, Transgenic KW - Adult KW - Methotrexate -- therapeutic use KW - Leukemic Infiltration KW - Middle Aged KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Immunophenotyping KW - Female KW - Male KW - Liver -- pathology KW - Antigens, CD95 -- genetics KW - Leukemia, Lymphoid -- drug therapy KW - Leukemia, Lymphoid -- pathology KW - Leukemia, Lymphoid -- metabolism KW - Liver -- metabolism KW - Lung -- pathology KW - Lung -- metabolism KW - Membrane Glycoproteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71117994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+haematology&rft.atitle=Clinicopathological+features+of+aggressive+large+granular+lymphocyte+leukaemia+resemble+Fas+ligand+transgenic+mice.&rft.au=Lamy%2C+T%3BBauer%2C+F+A%3BLiu%2C+J+H%3BLi%2C+Y+X%3BPillemer%2C+E%3BShahidi%2C+H%3BGregory%2C+S+A%3BZambello%2C+R%3BMarcolongo%2C+R%3BSemenzato%2C+G%3BLoughran%2C+T+P&rft.aulast=Lamy&rft.aufirst=T&rft.date=2000-03-01&rft.volume=108&rft.issue=4&rft.spage=717&rft.isbn=&rft.btitle=&rft.title=British+journal+of+haematology&rft.issn=00071048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-14 N1 - Date created - 2000-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Who fares poorly with alcoholic cirrhosis? AN - 71088460; 10795352 JF - Addiction (Abingdon, England) AU - Hermos, J A AD - Medical Service, Veterans Administration Medical Center, Boston, MA, USA. Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 350 EP - 1; discussion 355-8 VL - 95 IS - 3 SN - 0965-2140, 0965-2140 KW - Index Medicus KW - Humans KW - United States -- epidemiology KW - Male KW - Female KW - Liver Cirrhosis, Alcoholic -- etiology KW - Hepatitis C -- complications KW - Liver Cirrhosis, Alcoholic -- mortality KW - Alcohol Drinking -- psychology KW - Alcohol Drinking -- adverse effects KW - Hepatitis C -- epidemiology KW - Alcohol Drinking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71088460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Who+fares+poorly+with+alcoholic+cirrhosis%3F&rft.au=Hermos%2C+J+A&rft.aulast=Hermos&rft.aufirst=J&rft.date=2000-03-01&rft.volume=95&rft.issue=3&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-25 N1 - Date created - 2000-05-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Addiction. 2000 Mar;95(3):339-46 [10795350] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Radioactive contamination of packing materials from a xenon-133 shipment. AN - 71064548; 10763784 AB - We report on radioactive contamination of packing materials from a 133Xe shipment. A 2-vial 133Xe shipment was monitored using a survey meter before opening. Both vials were immediately assayed in a dose calibrator. The packing materials were monitored and contamination was detected. The maximum surface reading of the shipment was 7.0 microSv/h. This was higher than previous shipments (1.1 +/- 0.3 microSv/h). One vial was 544 MBq while the other vial was only 474 MBq. Previous shipments were 565 +/- 13 MBq/vial. Monitoring and imaging revealed 133Xe contamination within the packing materials. Xenon-133 escaped from the packing materials over time. The lower activity vial continued to leak 133Xe over time. Careful monitoring of 133Xe shipments before and after opening along with assaying vials on receipt can indicate vial leakage and radioactive contamination so steps can be taken to minimize radiation exposure to the staff. JF - Journal of nuclear medicine technology AU - Hackett, M T AU - Magoun, S L AD - Radiation Safety Office and Nuclear Medicine Service, Department of Veterans Affairs Medical Center, Lexington, Kentucky 40511-1093, USA. hackett.michael_t@lexington.med.va.gov Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 56 EP - 59 VL - 28 IS - 1 SN - 0091-4916, 0091-4916 KW - Polystyrenes KW - 0 KW - Xenon Radioisotopes KW - Index Medicus KW - Humans KW - Product Packaging KW - Radiation Monitoring UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71064548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+technology&rft.atitle=Radioactive+contamination+of+packing+materials+from+a+xenon-133+shipment.&rft.au=Hackett%2C+M+T%3BMagoun%2C+S+L&rft.aulast=Hackett&rft.aufirst=M&rft.date=2000-03-01&rft.volume=28&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+technology&rft.issn=00914916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-08 N1 - Date created - 2000-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A simple solution to prevent the loss of radioactive spot markers. AN - 71034263; 10763781 AB - Most nuclear medicine technologists have experienced the misplacing and/or the loss of a radioactive spot marker. We report on a simple solution to prevent or at least minimize the loss of radioactive spot markers. One end of a metallic beaded chain was attached to the side of 57Co spot marker using repair putty. The other end of the beaded chain was attached to a lead shield that housed the radioactive source when not in use. This design has allowed easy, unobstructed use of the 57Co spot marker for marking the right or left side and anatomical position during imaging while preventing its loss. A radioactive spot marker that is attached to a lead shield by a beaded chain is a simple way to prevent its loss while allowing it to be used easily during imaging. JF - Journal of nuclear medicine technology AU - Hackett, M T AU - Wierzbinski, R S AD - Radiation Safety Office and Nuclear Medicine Service, Department of Veterans Affairs Medical Center, Lexington, Kentucky 40511-1093, USA. hackett.michael_t@lexington.med.va.gov Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 45 EP - 48 VL - 28 IS - 1 SN - 0091-4916, 0091-4916 KW - Cobalt Radioisotopes KW - 0 KW - Index Medicus KW - Humans KW - Technology, Radiologic KW - Radiation Protection -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71034263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+technology&rft.atitle=A+simple+solution+to+prevent+the+loss+of+radioactive+spot+markers.&rft.au=Hackett%2C+M+T%3BWierzbinski%2C+R+S&rft.aulast=Hackett&rft.aufirst=M&rft.date=2000-03-01&rft.volume=28&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+technology&rft.issn=00914916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-06-08 N1 - Date created - 2000-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CNS oxidative stress associated with the kainic acid rodent model of experimental epilepsy. AN - 70941217; 10690755 AB - The role of oxidative stress in seizure-induced brain injury was investigated in a kainic acid model of experimental epilepsy. Kainic acid (12.5 mg/kg) or saline was injected intraperitoneally into 12-week-old male Fischer 344 rats and sacrificed by decapitation at 4 and 24 h after injection. Markers of oxidative stress including protein carbonyls, thiobarbituric acid reactive material (TBARs), glutathione (GSH) and glutathione disulfide (GSSG) were measured in hippocampus, cortex, cerebellum and basal ganglia. Four hours after treatment, protein carbonyls were elevated by 103, 55, 52 and 32% in cortex, hippocampus, basal ganglia and cerebellum, respectively. TBARs were increased by 30-45% in all areas. After 24 h, elevated protein and lipid oxidative markers persisted in the hippocampus and cerebellum; by contrast, in the cortex, TBARs almost normalized to control values and protein carbonyls trended downward by one-half compared with measurements at 4 h, although this reduction relative to the 4 h timepoint did not reach statistical significance. In the basal ganglia, protein carbonyls approached control values at 24 h. GSSG levels were only increased statistically in the cortex after 4 h, GSH levels in all the regions were unchanged after treatment with kainic acid. However, in cortex, GSH levels correlated negatively with increases in protein and lipid oxidation (r = -0.69, P < 0.002). In contrast, significant correlations between GSH, protein carbonyls and TBARs measured in the hippocampus or cerebellum were not observed. Our data suggests that kainic acid induced similar oxidative stress in all of the brain regions that were examined, and that GSH plays a major antioxidant role in the cerebral cortex but not the hippocampus. JF - Epilepsy research AU - Gluck, M R AU - Jayatilleke, E AU - Shaw, S AU - Rowan, A J AU - Haroutunian, V AD - Department of Neurology, Bronx Veterans Administration Medical Center, NY 10468, USA. Y1 - 2000/03// PY - 2000 DA - March 2000 SP - 63 EP - 71 VL - 39 IS - 1 SN - 0920-1211, 0920-1211 KW - Excitatory Amino Acid Agonists KW - 0 KW - Thiobarbituric Acid Reactive Substances KW - Glutathione KW - GAN16C9B8O KW - Kainic Acid KW - SIV03811UC KW - Glutathione Disulfide KW - ULW86O013H KW - Index Medicus KW - Thiobarbituric Acid Reactive Substances -- metabolism KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Kainic Acid -- pharmacology KW - Glutathione Disulfide -- drug effects KW - Glutathione Disulfide -- metabolism KW - Glutathione -- metabolism KW - Excitatory Amino Acid Agonists -- pharmacology KW - Glutathione -- drug effects KW - Male KW - Oxidative Stress -- physiology KW - Epilepsy -- chemically induced KW - Cerebral Cortex -- drug effects KW - Cerebral Cortex -- metabolism KW - Cerebellum -- drug effects KW - Hippocampus -- metabolism KW - Oxidative Stress -- drug effects KW - Epilepsy -- metabolism KW - Hippocampus -- drug effects KW - Cerebellum -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70941217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsy+research&rft.atitle=CNS+oxidative+stress+associated+with+the+kainic+acid+rodent+model+of+experimental+epilepsy.&rft.au=Gluck%2C+M+R%3BJayatilleke%2C+E%3BShaw%2C+S%3BRowan%2C+A+J%3BHaroutunian%2C+V&rft.aulast=Gluck&rft.aufirst=M&rft.date=2000-03-01&rft.volume=39&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Epilepsy+research&rft.issn=09201211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-05-04 N1 - Date created - 2000-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sensitization to soybean hull allergens in subjects exposed to different levels of soybean dust inhalation in Argentina AN - 17656341; 4700412 AB - Soybean hulls (SHs) have been identified as the source of aeroallergens responsible for soybean asthma outbreaks. However, the prevalence of sensitization to SH allergens in subjects from Argentina, a country where soybeans are produced, is unknown. The purpose of this study was to determine the prevalence of sensitization to SH by in vivo and in vitro tests in subjects with asthma or allergic rhinitis and in control subjects from Argentina who have been exposed to different levels of soybean dust inhalation (SDI). Exposure to SDI is defined as follows: (1) direct = occupational, (2) indirect = proximity to soybean fields or grain elevators, and (3) urban = urbanized areas without a known source of SDI. Two groups were studied. Group 1 consisted of 365 subjects with asthma or allergic rhinitis and group 2 (control group) of 50 healthy individuals. Subjects from both groups were classified according to their exposure to SDI. All subjects completed standard questionnaires. Prick skin tests (STs) with an SH extract and with common allergens were performed on all subjects. Specific IgE and IgG4 to SH were measured in sera of 51 of 56 subjects from group 1 who had a positive ST to SH and in all sera from group 2. Fifty-six (15.3%) subjects from group 1 and no subjects from group 2 had a positive ST to SH (wheal SH/wheal histamine greater than or equal to 0.5). In group 1, positive STs to SH were 38.7%, 20.3%, and 8.2% in subjects with direct, indirect, and urban exposures, respectively (P < .001). Monosensitization to SH is absent in all subjects from group 1. The percent of subjects with positive STs to mites, pollen, and molds was highest in those with a positive ST to SH versus those with a negative ST to SH (P < .01). Asthmatic patients with a positive ST to SH, compared with those exclusively sensitized to mites, had a higher frequency of daily or weekly symptoms (59.4% vs 25.7%, respectively, P < .001) and a higher percent of glucocorticoid dependence (52.8% vs 34%, respectively, P < .01). Percent positive IgE in group 1 and group 2 were 39.2% and 10% (P < .001) and percents positive IgG4 are 27.4% and 12%, respectively (not significant). In subjects from group 1 and group 2 with direct exposure percents positive IgE are 58.3% and 13.3% (P < .001) and percents positive IgG4 were 75% and 20%, respectively (P < .02). IgG4 in group 1 was significantly higher in subjects with direct exposure compared with subjects with indirect or urban exposure. This study demonstrated that there was (1) a high prevalence of sensitivity to SH in subjects with asthma or allergic rhinitis from Argentina and (2) an association between sensitivity to SH and severity of asthma and level of exposure to SDI. JF - Journal of Allergy and Clinical Immunology AU - Codina, R AU - Ardusso, L AU - Lockey, R F AU - Crisci, C AU - Bertoya, N AD - Division of Allergy and Immunology, Department of Medicine, University of South Florida and James A. Haley Veterans Administration Hospital, 13000 Bruce B. Downs Blvd (VAR 111D), Tampa, FL 33612-4745, USA Y1 - 2000/03// PY - 2000 DA - Mar 2000 SP - 570 EP - 576 VL - 105 IS - 3 SN - 0091-6749, 0091-6749 KW - immunology KW - Argentina KW - Glycine max KW - soybeans KW - Health & Safety Science Abstracts; Immunology Abstracts KW - Inhalation KW - Asthma KW - Dust KW - Soybeans KW - Allergens KW - H 11000:Diseases/Injuries/Trauma KW - F 06845:Allergens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17656341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Sensitization+to+soybean+hull+allergens+in+subjects+exposed+to+different+levels+of+soybean+dust+inhalation+in+Argentina&rft.au=Codina%2C+R%3BArdusso%2C+L%3BLockey%2C+R+F%3BCrisci%2C+C%3BBertoya%2C+N&rft.aulast=Codina&rft.aufirst=R&rft.date=2000-03-01&rft.volume=105&rft.issue=3&rft.spage=570&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Asthma; Allergens; Dust; Inhalation; Soybeans ER - TY - JOUR T1 - Stachybotrys chartarum: current knowledge of its role in disease. AN - 72456373; 11104457 AB - Stachybotrys chartarum is one of several species of filamentous fungi capable of producing mycotoxins under certain environmental conditions. In some observational studies, the growth of this toxigenic mold in the indoor environment has been implicated as a cause of building-related illness. Following reports of a cluster of cases of pulmonary hemosiderosis and hemorrhage associated with exposure to Stachybotrys, public health measures have been recommended which have far-reaching implications. Although the hazards associated with exposure to some mycotoxins have been well studied, the health risks from environmental exposure to Stachybotrys remain poorly defined. The purpose of this review is to critically evaluate the current body of epidemiologic knowledge regarding Stachybotrys and to increase physician awareness regarding this emerging environmental health issue. JF - MedGenMed : Medscape general medicine AU - Sudakin, D L AD - Veterans Administration Medical Center, Portland, Oregon, USA. sudakind@ohsu.edu Y1 - 2000/02/29/ PY - 2000 DA - 2000 Feb 29 SP - 1 VL - 2 IS - 1 KW - Mycotoxins KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Horse Diseases -- microbiology KW - Horses KW - Water Pollution -- adverse effects KW - Lung Diseases, Fungal -- etiology KW - Lung Diseases, Fungal -- microbiology KW - Cattle KW - Mycotoxins -- biosynthesis KW - Horse Diseases -- etiology KW - Case-Control Studies KW - Environmental Exposure KW - Mycotoxins -- adverse effects KW - United States -- epidemiology KW - Lung Diseases, Fungal -- epidemiology KW - Stachybotrys -- pathogenicity KW - Stachybotrys -- metabolism KW - Stachybotrys -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72456373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MedGenMed+%3A+Medscape+general+medicine&rft.atitle=Stachybotrys+chartarum%3A+current+knowledge+of+its+role+in+disease.&rft.au=Sudakin%2C+D+L&rft.aulast=Sudakin&rft.aufirst=D&rft.date=2000-02-29&rft.volume=2&rft.issue=1&rft.spage=E11&rft.isbn=&rft.btitle=&rft.title=MedGenMed+%3A+Medscape+general+medicine&rft.issn=1531-0132&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2000-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunosuppressive-associated leukoencephalopathy in organ transplant recipients. AN - 70952359; 10708096 AB - Immunosuppressive-associated leukoencephalopathy is a significant complication of cyclosporine (CsA) or tacrolimus therapy. However, the precise time of onset, role of putative risk factors, differences, if any, in presentation in various types of organ transplantation and outcome of this entity, remain poorly defined. Fifty cases of immunosuppressive-associated leukoencephalopathy reported in the literature in organ transplant recipients, were reviewed. Of 50 cases, 31 occurred in liver, 8 in renal, 6 in lung, and 5 in heart transplant recipients. Median time to onset was 28 days (range 3-1512 days); 82% occurred within 90 days of transplantation. Lesions tended to occur earlier in the liver transplant recipients, compared with other organ transplant recipients (median 9 vs. 29 days, P=.19). Seizures 74%, altered mental status 50%, and visual abnormalities 28% were the most frequently presenting features. Ten percent of the patients had fever with no documented source of infection. Systemic hypertension (P=.001), and lesions in the presence of therapeutic drug levels (P=.11) were more likely to occur with CsA than tacrolimus. Neuroimaging and clinical abnormalities were reversible on cessation or reduction of CsA or tacrolimus in all but two cases. Resolution of neurologic signs/symptoms occurred a median of 4 days and neuroimaging abnormalities in a median of 20 days on reduction/cessation of the drug. Immunosuppressive-associated leukoencephalopathy is a unique entity that can usually be diagnosed on the basis of its distinctive time of onset, and clinical and neuroimaging characteristics, and it is potentially reversible if promptly diagnosed. Despite identical clinical presentation of this syndrome in the recipients of CsA and tacrolimus, above noted variations in risk factors suggest that a difference in pathophysiologic mechanism may exist. JF - Transplantation AU - Singh, N AU - Bonham, A AU - Fukui, M AD - Veterans Administration Medical Center and University of Pittsburgh, Thomas E. Starzl Transplantation Institute, Pennsylvania 15240, USA. Y1 - 2000/02/27/ PY - 2000 DA - 2000 Feb 27 SP - 467 EP - 472 VL - 69 IS - 4 SN - 0041-1337, 0041-1337 KW - Immunosuppressive Agents KW - 0 KW - Cyclosporine KW - 83HN0GTJ6D KW - Tacrolimus KW - WM0HAQ4WNM KW - Index Medicus KW - Tacrolimus -- adverse effects KW - Cyclosporine -- adverse effects KW - Humans KW - Leukoencephalopathy, Progressive Multifocal -- chemically induced KW - Leukoencephalopathy, Progressive Multifocal -- therapy KW - Organ Transplantation KW - Immunosuppressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70952359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation&rft.atitle=Immunosuppressive-associated+leukoencephalopathy+in+organ+transplant+recipients.&rft.au=Singh%2C+N%3BBonham%2C+A%3BFukui%2C+M&rft.aulast=Singh&rft.aufirst=N&rft.date=2000-02-27&rft.volume=69&rft.issue=4&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Transplantation&rft.issn=00411337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-23 N1 - Date created - 2000-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: protection by triacetyloleandomycin. AN - 70874820; 10644054 AB - Ethanol and isopentanol are the predominant alcohols in alcoholic beverages. We have reported previously that pretreatment of rats with a liquid diet containing 6.3% ethanol plus 0.5% isopentanol for 7 days results in a synergistic increase in acetaminophen hepatotoxicity, compared with rats treated with either alcohol alone. Here, we investigated the role of CYP3A in acetaminophen hepatotoxicity associated with the combined alcohol treatment. Triacetyloleandomycin, a specific inhibitor of CYP3A, protected rats pretreated with ethanol along with isopentanol from acetaminophen hepatotoxicity. At both 0.25 and 0.5 g acetaminophen/kg, triacetyloleandomycin partially prevented elevations in serum levels of alanine aminotransferase. At 0.25 g acetaminophen/kg, triacetyloleandomycin completely protected 6 of 8 rats from histologically observed liver damage, and partially protected the remaining 2 rats. At 0.5 g acetaminophen/kg, triacetyloleandomycin decreased histologically observed liver damage in 7 of 15 rats. In rats pretreated with ethanol plus isopentanol, CYP3A, measured immunohistochemically, was decreased by acetaminophen treatment. This effect was prevented by triacetyloleandomycin. These results suggest that CYP3A has a major role in acetaminophen hepatotoxicity in animals administered the combined alcohol treatment. We also found that exposure to ethanol along with 0.1% isopentanol for only 3 days resulted in maximal increases in acetaminophen hepatotoxicity by the combined alcohol treatment, suggesting that short-term consumption of alcoholic beverages rich in isopentanol may be a risk for developing liver damage from acetaminophen. JF - Biochemical pharmacology AU - Sinclair, J F AU - Szakacs, J G AU - Wood, S G AU - Kostrubsky, V E AU - Jeffery, E H AU - Wrighton, S A AU - Bement, W J AU - Wright, D AU - Sinclair, P R AD - Veterans Administration Medical Center, White River Junction, VT 05009, USA. JSINC@dartmouth.edu Y1 - 2000/02/15/ PY - 2000 DA - 2000 Feb 15 SP - 445 EP - 454 VL - 59 IS - 4 SN - 0006-2952, 0006-2952 KW - Analgesics, Non-Narcotic KW - 0 KW - Cytochrome P-450 Enzyme Inhibitors KW - Pentanols KW - Protective Agents KW - Acetaminophen KW - 362O9ITL9D KW - Ethanol KW - 3K9958V90M KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Troleandomycin KW - C4DZ64560D KW - isopentyl alcohol KW - DEM9NIT1J4 KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP3A KW - Oxidoreductases, N-Demethylating KW - EC 1.5.- KW - Index Medicus KW - Animals KW - Drug Interactions KW - Cytochrome P-450 Enzyme System -- metabolism KW - Liver Diseases -- enzymology KW - Protective Agents -- pharmacology KW - Liver Diseases -- prevention & control KW - Rats KW - Rats, Inbred F344 KW - Analgesics, Non-Narcotic -- toxicity KW - Liver Diseases -- pathology KW - Oxidoreductases, N-Demethylating -- antagonists & inhibitors KW - Oxidoreductases, N-Demethylating -- metabolism KW - Male KW - Pentanols -- pharmacology KW - Troleandomycin -- pharmacology KW - Ethanol -- pharmacology KW - Chemical and Drug Induced Liver Injury KW - Pentanols -- administration & dosage KW - Ethanol -- administration & dosage KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70874820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Acetaminophen+hepatotoxicity+precipitated+by+short-term+treatment+of+rats+with+ethanol+and+isopentanol%3A+protection+by+triacetyloleandomycin.&rft.au=Sinclair%2C+J+F%3BSzakacs%2C+J+G%3BWood%2C+S+G%3BKostrubsky%2C+V+E%3BJeffery%2C+E+H%3BWrighton%2C+S+A%3BBement%2C+W+J%3BWright%2C+D%3BSinclair%2C+P+R&rft.aulast=Sinclair&rft.aufirst=J&rft.date=2000-02-15&rft.volume=59&rft.issue=4&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-02-03 N1 - Date created - 2000-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tumor grade, microvessel density, and activities of malate dehydrogenase, lactate dehydrogenase, and hexokinase in squamous cell carcinoma. AN - 85345445; pmid-10652389 AB - Squamous cell carcinomas were evaluated with respect to tumor differentiation (through use of hematoxylin and eosin stain), microvessel density (through use of CD-34 immunocytochemical stain), and magnitudes of malate dehydrogenase (MDH), hexokinase, and lactate dehydrogenase (LDH) enzyme activities. Direct correlations were found between tumor grade, MDH activity, and microvessel density. Direct correlations were also found between hexokinase activity and MDH activity and microvessel density. Inverse correlations were found between LDH activity and both tumor grade and MDH activity. These results suggest that the high rate of glucose utilization (indicated by hexokinase activity) found in more poorly differentiated tumors has a higher component of aerobic oxidative metabolism (indicated by MDH activity) and a relatively lower contribution from anaerobic metabolism (indicated by LDH activity) than do the rates found in more differentiated tumors. It is also suggested that as the glycolytic rate increases, more pyruvate goes into the Krebs cycle than into lactate. The availability of glucose-derived pyruvate for oxidative metabolism would mean less of a dependency on glutamine as a carbon source in squamous cell carcinoma. JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery AU - Ross, C D AU - Gomaa, M A AU - Gillies, E AU - Juengel, R AU - Medina, J E AD - Department of Otorhinolaryngology, University of Oklahoma Health Sciences Center and Veterans Administration Medical Center, Oklahoma City 73190-3048, USA. Y1 - 2000/02// PY - 2000 DA - Feb 2000 SP - 195 EP - 200 VL - 122 IS - 2 SN - 0194-5998, 0194-5998 KW - Index Medicus KW - National Library of Medicine KW - Otorhinolaryngologic Neoplasms -- blood supply KW - Carcinoma, Squamous Cell -- enzymology KW - Microcirculation -- pathology KW - Otorhinolaryngologic Neoplasms -- enzymology KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- blood supply KW - Humans KW - Otorhinolaryngologic Neoplasms -- pathology KW - Malate Dehydrogenase -- metabolism KW - Hexokinase -- metabolism KW - L-Lactate Dehydrogenase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85345445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=Tumor+grade%2C+microvessel+density%2C+and+activities+of+malate+dehydrogenase%2C+lactate+dehydrogenase%2C+and+hexokinase+in+squamous+cell+carcinoma.&rft.au=Ross%2C+C+D%3BGomaa%2C+M+A%3BGillies%2C+E%3BJuengel%2C+R%3BMedina%2C+J+E&rft.aulast=Ross&rft.aufirst=C&rft.date=2000-02-01&rft.volume=122&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Prospective evaluation of the prevalence of gastric Helicobacter pylori infection in patients with GERD, Barrett's esophagus, Barrett's dysplasia, and Barrett's adenocarcinoma. AN - 85340018; pmid-10685740 AB - OBJECTIVE: This study was undertaken to prospectively determine the prevalence of gastric H. pylori infection in Barrett's esophagus and Barrett's complicated by dysplasia or adenocarcinoma. METHODS: The prevalence of H. pylori was determined in Barrett's esophagus patients compared to a control population of patients with gastroesophageal reflux disease (GERD) only. All patients had a minimum of 10 gastric surveillance biopsies obtained. H. pylori colonization was determined upon the basis of hematoxylin and eosin and use of a modified Giemsa and or Steiner's silver stain of all gastric biopsy specimens. RESULTS: Two hundred and eighty-nine Barrett's patients and 217 GERD control patients were included in the study. H. pylori was found in 95/289 (32.9%) of the Barrett's patients, compared with 96/217 (44.2%) of the GERD controls (NS). Forty-seven of the Barrett's patients had low-grade dysplasia/indefinite dysplasia, 14 high-grade dysplasia, and 20 Barrett's adenocarcinoma. When Barrett's was subgrouped according to absence of dysplasia, and presence of low-grade dysplasia, high-grade dysplasia, or adenocarcinoma, H. pylori prevalence was found to be significantly less for patients with Barrett's high-grade dysplasia (14.3%) and adenocarcinoma (15.0%) versus patients with GERD alone (44.2%), Barrett's alone (35.1%), or Barrett's with low-grade dysplasia (36.2%) (p = 0.016). This difference could not be explained by differences between Barrett's esophagus patients infected with H. pylori and those who were not with respect to gender, smoking history, alcohol consumption, use of proton pump inhibitor, or length of Barrett's mucosa. CONCLUSIONS: Barrett's high-grade dysplasia and adenocarcinoma are significantly more prevalent in patients who are not infected with H. pylori. H. pylori appears to have a protective effect against the development of Barrett's adenocarcinoma. JF - The American journal of gastroenterology AU - Weston, A P AU - Badr, A S AU - Topalovski, M AU - Cherian, R AU - Dixon, A AU - Hassanein, R S AD - Veterans Administration Medical Center, Kansas City, Missouri, 64128, USA. Y1 - 2000/02// PY - 2000 DA - Feb 2000 SP - 387 EP - 394 VL - 95 IS - 2 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Analysis of Variance KW - Gastroesophageal Reflux -- microbiology KW - Chi-Square Distribution KW - Humans KW - Biopsy KW - Esophagoscopy KW - Barrett Esophagus -- epidemiology KW - Smoking -- epidemiology KW - Esophageal Neoplasms -- epidemiology KW - Adenocarcinoma -- epidemiology KW - Proton Pumps -- antagonists & inhibitors KW - Kansas -- epidemiology KW - Adenocarcinoma -- microbiology KW - Barrett Esophagus -- pathology KW - Barrett Esophagus -- microbiology KW - Male KW - Enzyme Inhibitors -- therapeutic use KW - Gastroesophageal Reflux -- epidemiology KW - Stomach Diseases -- microbiology KW - Alcohol Drinking -- epidemiology KW - Coloring Agents KW - Prospective Studies KW - Stomach Diseases -- epidemiology KW - Gastroesophageal Reflux -- drug therapy KW - Middle Aged KW - Follow-Up Studies KW - Esophageal Neoplasms -- microbiology KW - Helicobacter pylori -- growth & development KW - Female KW - Prevalence KW - Helicobacter Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85340018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Prospective+evaluation+of+the+prevalence+of+gastric+Helicobacter+pylori+infection+in+patients+with+GERD%2C+Barrett%27s+esophagus%2C+Barrett%27s+dysplasia%2C+and+Barrett%27s+adenocarcinoma.&rft.au=Weston%2C+A+P%3BBadr%2C+A+S%3BTopalovski%2C+M%3BCherian%2C+R%3BDixon%2C+A%3BHassanein%2C+R+S&rft.aulast=Weston&rft.aufirst=A&rft.date=2000-02-01&rft.volume=95&rft.issue=2&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Aggressive multimodality therapy for stage III esophageal cancer: a phase I/II study. AN - 70984754; 10735664 AB - Stage III advanced locoregional esophageal carcinoma is frequently unresectable and inconsistently represented in therapeutic trials of esophageal cancer. From 1992 to 1998, 34 of 131 total esophageal cancer patients were designated stage III (16 T3N1, 9 T4N0, 9 T4N1) and medically fit to enter a combined modality protocol with continuous infusion 5-fluorouracil (CIS-FU, 300 to 600 mg/m2/day), high-dose external beam irradiation (60 Gy), and interval esophagectomy. Staging before and after induction therapy included computed tomography; endoscopy, and endoscopic ultrasound. Significant toxicity from induction therapy included death (5/34; 14.7%), pneumonitis (5/34; 14.7%), mucositis (13/34; 38%), and hand-foot syndrome (3/34; 8.8%). In addition to the five deaths, 11 patients did not proceed to operation because of development of esophagorespiratory fistula in 3, distant disease in 2, persistence of T4 stage in 2, progression of comorbidities in 2, and patient refusal in 2. There was a discrepancy between clinical complete response (cCR) at restaging 56% (19/34) and pathologic CR (pCR) noted at the time of operation (8/34; 23.5%). Complete resections were possible in 16 of 18 patients explored. Complications in 4 patients included: death (1), airway injury (1), chylothorax requiring reoperation (1), anastomotic leak (1), recurrent nerve injury with vocal cord paresis (2), and ascaris infection (1). Actuarial survival analysis using the Kaplan-Meier method and log-rank testing showed a 36-month survival of 20% for the group as a whole and 27% for patients restaged cCR (cCR vs PR, p = 0.0046). Treatment failure is predominantly distant, with good local control in resected patients. N0 node status was strongly associated with survival (N0 vs N1 p = 0.0024). There is a trend towards improved survival in the resected group (resected 22% vs nonresected 10% at 3 years, p = 0.17). Response rates and survival are commensurate with multiple completed phase II and III trials. These are attained at a higher treatment-related mortality. T4 patients can be successfully resected in selected patients. Even in advanced disease, nodal status is a significant predictor of survival. JF - The Annals of thoracic surgery AU - Alexander, E P AU - Lipman, T AU - Harmon, J AU - Wadleigh, R AD - Division of Cardiothoracic Surgery, Washington, DC VAMC, USA. epalexander@med.va.gov Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 363 EP - 368 VL - 69 IS - 2 SN - 0003-4975, 0003-4975 KW - Antimetabolites, Antineoplastic KW - 0 KW - Fluorouracil KW - U3P01618RT KW - Abridged Index Medicus KW - Index Medicus KW - Fluorouracil -- therapeutic use KW - Neoplasm Staging KW - Esophagectomy KW - Combined Modality Therapy KW - Humans KW - Aged KW - Middle Aged KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Male KW - Survival Analysis KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- mortality KW - Adenocarcinoma -- mortality KW - Esophageal Neoplasms -- therapy KW - Adenocarcinoma -- therapy KW - Esophageal Neoplasms -- pathology KW - Esophageal Neoplasms -- mortality KW - Carcinoma, Squamous Cell -- therapy KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70984754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+thoracic+surgery&rft.atitle=Aggressive+multimodality+therapy+for+stage+III+esophageal+cancer%3A+a+phase+I%2FII+study.&rft.au=Alexander%2C+E+P%3BLipman%2C+T%3BHarmon%2C+J%3BWadleigh%2C+R&rft.aulast=Alexander&rft.aufirst=E&rft.date=2000-02-01&rft.volume=69&rft.issue=2&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+thoracic+surgery&rft.issn=00034975&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-12 N1 - Date created - 2000-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Predictors of expressed partner and non-partner violence among patients in substance abuse treatment. AN - 70899753; 10669054 AB - This study examined reports of expressed partner and non-partner violence among men (n = 126) and women (n = 126) in the 12 months prior to substance abuse treatment. Rates of violence were 57% for partner, 53% for non-partner, and 75% collapsing across partner and non-partner relationships. Factors associated with partner and non-partner violence severity differed substantially. Partner violence was predicted by age, marital status, and drug problem severity. Non-partner violence was predicted by gender, income, alcohol and drug problem severity. The results highlight that individuals in substance abuse treatment are at high risk for violence, and targeted screening and intervention approaches should be routine in addictions treatment. JF - Drug and alcohol dependence AU - Chermack, S T AU - Fuller, B E AU - Blow, F C AD - John D. Dingell VA Medical Center, Detroit, MI 48201, USA. stephen.chermack@med.va.gov Y1 - 2000/02/01/ PY - 2000 DA - 2000 Feb 01 SP - 43 EP - 54 VL - 58 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Index Medicus KW - Socioeconomic Factors KW - Analysis of Variance KW - Risk Factors KW - Humans KW - Chi-Square Distribution KW - Interpersonal Relations KW - Adult KW - Surveys and Questionnaires KW - Aged KW - Predictive Value of Tests KW - Middle Aged KW - Male KW - Female KW - Violence -- statistics & numerical data KW - Domestic Violence -- statistics & numerical data KW - Substance-Related Disorders -- complications KW - Domestic Violence -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Violence -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70899753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Predictors+of+expressed+partner+and+non-partner+violence+among+patients+in+substance+abuse+treatment.&rft.au=Chermack%2C+S+T%3BFuller%2C+B+E%3BBlow%2C+F+C&rft.aulast=Chermack&rft.aufirst=S&rft.date=2000-02-01&rft.volume=58&rft.issue=1-2&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-14 N1 - Date created - 2000-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Seizure suppression by systemic epinephrine is mediated by the vagus nerve. AN - 70879034; 10642045 AB - The present study investigated the seizure-suppressing effects of systemic epinephrine. Rats were injected with epinephrine, and seizures induced with pentylenetetrazol. Seizure severities were significantly reduced 15 min after 1 mg/kg of epinephrine. Severing the subdiaphragmatic vagus nerves abolished this effect, demonstrating that epinephrine-induced seizure suppression is mediated by subdiaphragmatic vagal afferents. The development of novel anti-epileptic drugs that exploit this peripheral pathway may yield new seizure treatments. JF - Epilepsy research AU - Krahl, S E AU - Senanayake, S S AU - Handforth, A AD - Neurology Service, West Los Angeles VA Medical Center, California 90073, USA. scott.krahl@med.va.gov Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 171 EP - 175 VL - 38 IS - 2-3 SN - 0920-1211, 0920-1211 KW - Anticonvulsants KW - 0 KW - Convulsants KW - Pentylenetetrazole KW - WM5Z385K7T KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Afferent Pathways -- drug effects KW - Pentylenetetrazole -- toxicity KW - Vagotomy KW - Female KW - Convulsants -- toxicity KW - Seizures -- chemically induced KW - Anticonvulsants -- pharmacology KW - Vagus Nerve -- physiology KW - Seizures -- physiopathology KW - Epinephrine -- pharmacology KW - Seizures -- prevention & control KW - Anticonvulsants -- therapeutic use KW - Epinephrine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70879034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsy+research&rft.atitle=Seizure+suppression+by+systemic+epinephrine+is+mediated+by+the+vagus+nerve.&rft.au=Krahl%2C+S+E%3BSenanayake%2C+S+S%3BHandforth%2C+A&rft.aulast=Krahl&rft.aufirst=S&rft.date=2000-02-01&rft.volume=38&rft.issue=2-3&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Epilepsy+research&rft.issn=09201211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-02-14 N1 - Date created - 2000-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comprehensive review of the psychiatric uses of valproate. AN - 70866937; 10646685 AB - The therapeutic effects of valproate in psychiatric conditions are most substantially recognized in bipolar disorder. However, this well-tolerated medication may be beneficial in the treatment of other mental illnesses. In this article, the authors comprehensively review studies of valproate as treatment for psychiatric conditions, including bipolar, depressive, anxiety, and psychotic disorders; alcohol withdrawal and dependence; tardive dyskinesia; agitation associated with dementia; and borderline personality disorder. Valproate shows the most promising efficacy in treating mood and anxiety disorders, with possible efficacy in the treatment of agitation and impulsive aggression, and less convincing therapeutic response in treating psychosis and alcohol withdrawal or dependence. The authors conclude with a brief summary of its mechanism of action and therapeutic spectrum. JF - Journal of clinical psychopharmacology AU - Davis, L L AU - Ryan, W AU - Adinoff, B AU - Petty, F AD - Veteran's Affairs Medical Center, Tuscaloosa, Alabama 35404, USA. davis.lori@tuscaloosa.va.gov Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 1S EP - 17S VL - 20 IS - 1 Suppl 1 SN - 0271-0749, 0271-0749 KW - Anticonvulsants KW - 0 KW - Antimanic Agents KW - Valproic Acid KW - 614OI1Z5WI KW - Index Medicus KW - Depressive Disorder, Major -- drug therapy KW - Anxiety Disorders -- drug therapy KW - Humans KW - Bipolar Disorder -- drug therapy KW - Substance Withdrawal Syndrome -- drug therapy KW - Mood Disorders -- drug therapy KW - Female KW - Psychotic Disorders -- drug therapy KW - Pregnancy KW - Antimanic Agents -- therapeutic use KW - Valproic Acid -- therapeutic use KW - Anticonvulsants -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70866937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Comprehensive+review+of+the+psychiatric+uses+of+valproate.&rft.au=Davis%2C+L+L%3BRyan%2C+W%3BAdinoff%2C+B%3BPetty%2C+F&rft.aulast=Davis&rft.aufirst=L&rft.date=2000-02-01&rft.volume=20&rft.issue=1+Suppl+1&rft.spage=1S&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-02-16 N1 - Date created - 2000-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - High-level expression of chromosomally encoded SHV-1 beta-lactamase and an outer membrane protein change confer resistance to ceftazidime and piperacillin-tazobactam in a clinical isolate of Klebsiella pneumoniae. AN - 70866715; 10639363 AB - We describe Klebsiella pneumoniae 15571, a clinical isolate resistant to ceftazidime MIC = 32 microg/ml) and piperacillin-tazobactam (MICs = 1,024 and 128 microg/ml). K. pneumoniae 15571 expresses a single beta-lactamase with a pI of 7.6. However, when cloned in a high-copy-number vector in Escherichia coli, this bla(SHV-1) gene did not confer resistance to ceftazidime, a spectrum consistent with the nucleotide sequence, which was nearly identical to those of previously described bla(SHV-1) genes. Outer membrane protein (OMP) analysis of K. pneumoniae 15571 revealed a decrease in the quantity of a minor 45-kDa OMP in comparison to that in K. pneumoniae 44NR, a low-level ampicillin-resistant strain that also expresses a chromosomally determined bla(SHV-1). Crude beta-lactamase enzyme extracts from K. pneumoniae 15571 produced roughly 200-fold more beta-lactamase activity than K. pneumoniae 44NR. Northern hybridization analysis revealed that this difference was explainable by quantifiable differences in transcription of the bla(SHV-1) gene in the two strains. Primer extension analysis of bla(SHV-1) mRNA from K. pneumoniae 15571 and 44NR indicated that the transcriptional start sites were identical in the two strains. DNA sequencing of the promoter regions upstream of the of bla(SHV-1) open reading frames in the two K. pneumoniae strains revealed an A-->C change in the second position of the -10 region in K. pneumoniae 44NR compared to that in 15571. Site-directed mutagenesis of the cloned K. pneumoniae 15571 bla(SHV-1), in which the A in the second position of the 15571 -10 region was changed to a C, resulted in a substantial lowering of the MIC of ampicillin. When the levels of beta-lactamase enzyme expression in E. coli were compared, the bla(SHV-1) downstream of the altered -10 region produced 17-fold less beta-lactamase enzyme. These results indicate that elevated levels of ceftazidime resistance can result from a combination of increased enzyme production and minor OMP changes and that levels of chromosomally encoded SHV-1 beta-lactamase production can vary substantially with a single-base-pair change in promoter sequence. JF - Antimicrobial agents and chemotherapy AU - Rice, L B AU - Carias, L L AU - Hujer, A M AU - Bonafede, M AU - Hutton, R AU - Hoyen, C AU - Bonomo, R A AD - Medical Service, Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA. louis.rice@med.va.gov Y1 - 2000/02// PY - 2000 DA - February 2000 SP - 362 EP - 367 VL - 44 IS - 2 SN - 0066-4804, 0066-4804 KW - Bacterial Outer Membrane Proteins KW - 0 KW - Cephalosporins KW - DNA, Bacterial KW - Enzyme Inhibitors KW - Penicillins KW - Penicillanic Acid KW - 87-53-6 KW - Ceftazidime KW - 9M416Z9QNR KW - beta-lactamase PIT-2 KW - EC 3.5.2.- KW - beta-Lactamases KW - EC 3.5.2.6 KW - tazobactam KW - SE10G96M8W KW - Piperacillin KW - X00B0D5O0E KW - Index Medicus KW - Penicillins -- pharmacology KW - Cephalosporins -- pharmacology KW - Sequence Homology, Nucleic Acid KW - Humans KW - Drug Resistance, Microbial -- genetics KW - Biological Transport KW - Nucleic Acid Hybridization KW - DNA, Bacterial -- analysis KW - Cloning, Molecular KW - Drug Resistance, Microbial -- physiology KW - Base Sequence KW - Chromosomes KW - Molecular Sequence Data KW - Gene Expression Regulation, Bacterial -- drug effects KW - Enzyme Inhibitors -- pharmacology KW - Promoter Regions, Genetic -- genetics KW - Microbial Sensitivity Tests KW - Bacterial Outer Membrane Proteins -- biosynthesis KW - beta-Lactamases -- biosynthesis KW - Klebsiella pneumoniae -- drug effects KW - Penicillanic Acid -- pharmacology KW - Klebsiella pneumoniae -- genetics KW - Ceftazidime -- pharmacology KW - Bacterial Outer Membrane Proteins -- metabolism KW - Klebsiella pneumoniae -- metabolism KW - beta-Lactamases -- genetics KW - Piperacillin -- pharmacology KW - Penicillanic Acid -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70866715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=High-level+expression+of+chromosomally+encoded+SHV-1+beta-lactamase+and+an+outer+membrane+protein+change+confer+resistance+to+ceftazidime+and+piperacillin-tazobactam+in+a+clinical+isolate+of+Klebsiella+pneumoniae.&rft.au=Rice%2C+L+B%3BCarias%2C+L+L%3BHujer%2C+A+M%3BBonafede%2C+M%3BHutton%2C+R%3BHoyen%2C+C%3BBonomo%2C+R+A&rft.aulast=Rice&rft.aufirst=L&rft.date=2000-02-01&rft.volume=44&rft.issue=2&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-23 N1 - Date created - 2000-03-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biotechniques. 1998 Jul;25(1):72-4, 76, 78 [9668979] Antimicrob Agents Chemother. 1990 Aug;34(8):1577-83 [2221867] J Bacteriol. 1999 May;181(9):2726-32 [10217760] Biochem J. 1988 Apr 1;251(1):73-9 [3260490] FEMS Microbiol Lett. 1990 Feb;55(3):319-23 [2182386] Antimicrob Agents Chemother. 1990 Nov;34(11):2193-9 [2073110] J Gen Microbiol. 1991 Mar;137(3):569-78 [2033379] Antimicrob Agents Chemother. 1991 Sep;35(9):1697-704 [1952834] FEMS Microbiol Lett. 1992 Apr 1;71(1):89-94 [1624115] J Gen Microbiol. 1972 Oct;72(3):543-52 [4564689] Eur J Biochem. 1977 Jan;72(2):341-52 [319999] Antimicrob Agents Chemother. 1983 Aug;24(2):186-9 [6605714] Nucleic Acids Res. 1984 Apr 11;12(7):3219-34 [6326054] J Clin Microbiol. 1984 Oct;20(4):608-13 [6092432] J Infect Dis. 1985 Mar;151(3):501-7 [2982966] FEBS Lett. 1986 Oct 20;207(1):69-74 [3533626] Antimicrob Agents Chemother. 1993 May;37(5):1061-4 [8390809] J Antimicrob Chemother. 1993 Nov;32 Suppl B:63-74 [8150768] J Infect Dis. 1996 Jan;173(1):151-8 [8537652] Antimicrob Agents Chemother. 1996 Feb;40(2):342-8 [8834877] Antimicrob Agents Chemother. 1997 Feb;41(2):468-70 [9021210] Antimicrob Agents Chemother. 1997 Mar;41(3):563-9 [9055993] Antimicrob Agents Chemother. 1997 Jun;41(6):1322-5 [9174192] J Antimicrob Chemother. 1997 Jun;39(6):737-45 [9222043] J Infect Dis. 1990 Aug;162(2):460-5 [2197339] Antimicrob Agents Chemother. 1999 Feb;43(2):367-70 [9925535] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intracisternal PYY inhibits gastric lesions induced by ethanol in rats: role of PYY-preferring receptors? AN - 71061310; 10784103 AB - We previously reported that intracisternal (i.c.) injection of peptide YY (PYY) and low doses of thyrotropin-releasing hormone (TRH) or TRH analog, RX 77368, increased the resistance of the gastric mucosa to ethanol injury through vagal pathways in rats. The gastroprotective effect of i.c. injection of PYY/neuropeptide NPY (NPY) agonists with differential in vitro affinity to the Y receptor subtypes was examined in urethane-anesthetized rats. Intragastric administration of ethanol (45%, 5 ml/kg) results in mucosal lesions covering 23+/-2% of the gastric corpus in 1 h. PYY (500 ng, i.c.) significantly reduced ethanol-induced gastric lesions by 52%. [Pro34]PYY (PYY-preferring/Y1/Y5/Y4 subtypes) injected i.c. at 50, 100, 200 or 500 ng, reduced dose dependently gastric lesions to 15.4+/-2.2%, 11.4+/-3.1%, 8.6+/-2.9% and 5.4+/-2.2%, respectively. PYY3-36, (Y2/Y4 subtypes), [Leu31, Pro34]NPY (Y1/Y5), NPY (Y3/Y1/Y5/Y2) and pancreatic polypeptide (PP, Y4) injected i.c. at 500 ng did not influence significantly ethanol-induced gastric lesions. Combined i.c. injection of RX 77368 (1 ng) and Pro34PYY (25 ng), at sub-threshold doses given singly, reduced ethanol-induced gastric injury to 12.9+/-2.3% while RX 77368 (1 ng) plus PYY3-36 (500 ng) or [Leu31, Pro34]NPY (25 ng) had no effect. These findings indicate that i.c. PYY-induced gastric protection against 45% ethanol is mediated by a Y receptor subtype which bears similarity with the putative PYY-preferring receptor and distinct from the currently defined Y1/Y5; in addition, there is a synergistic interaction between activation of this PYY-preferring receptor and i.c. TRH to increase the resistance of the gastric mucosa to injury caused by 45% ethanol. JF - Brain research AU - Kawakubo, K AU - Yang, H AU - Taché, Y AD - CURE: Digestive Diseases Research Center, Veterans Administration Greater Los Angeles Healthcare System, CA 90073, USA. Y1 - 2000/01/31/ PY - 2000 DA - 2000 Jan 31 SP - 30 EP - 34 VL - 854 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Receptors, Gastrointestinal Hormone KW - 0 KW - peptide YY receptor KW - Peptide YY KW - 106388-42-5 KW - Ethanol KW - 3K9958V90M KW - Thyrotropin-Releasing Hormone KW - 5Y5F15120W KW - L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide KW - 76820-40-1 KW - Pyrrolidonecarboxylic Acid KW - SZB83O1W42 KW - Index Medicus KW - Animals KW - Stomach Diseases -- chemically induced KW - Thyrotropin-Releasing Hormone -- analogs & derivatives KW - Dose-Response Relationship, Drug KW - Stomach Diseases -- physiopathology KW - Stomach Diseases -- prevention & control KW - Pyrrolidonecarboxylic Acid -- analogs & derivatives KW - Rats KW - Thyrotropin-Releasing Hormone -- pharmacology KW - Rats, Sprague-Dawley KW - Drug Synergism KW - Injections KW - Male KW - Receptors, Gastrointestinal Hormone -- physiology KW - Ethanol -- pharmacology KW - Gastric Mucosa -- drug effects KW - Cisterna Magna -- metabolism KW - Cisterna Magna -- physiopathology KW - Gastric Mucosa -- pathology KW - Peptide YY -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71061310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Intracisternal+PYY+inhibits+gastric+lesions+induced+by+ethanol+in+rats%3A+role+of+PYY-preferring+receptors%3F&rft.au=Kawakubo%2C+K%3BYang%2C+H%3BTach%C3%A9%2C+Y&rft.aulast=Kawakubo&rft.aufirst=K&rft.date=2000-01-31&rft.volume=854&rft.issue=1-2&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-27 N1 - Date created - 2000-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Do cyclooxygenase-2 inhibitors provide benefits similar to those of traditional nonsteroidal anti-inflammatory drugs, with less gastrointestinal toxicity? AN - 70812865; 10644275 JF - Annals of internal medicine AU - Feldman, M AU - McMahon, A T AD - University of Texas Southwestern Medical Center, Dallas, USA. mark.feldman@med.va.gov Y1 - 2000/01/18/ PY - 2000 DA - 2000 Jan 18 SP - 134 EP - 143 VL - 132 IS - 2 SN - 0003-4819, 0003-4819 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase 2 Inhibitors KW - Cyclooxygenase Inhibitors KW - Isoenzymes KW - Membrane Proteins KW - Cyclooxygenase 1 KW - EC 1.14.99.1 KW - Cyclooxygenase 2 KW - PTGS1 protein, human KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Abridged Index Medicus KW - Index Medicus KW - Controlled Clinical Trials as Topic KW - Animals KW - Humans KW - Cyclooxygenase Inhibitors -- therapeutic use KW - Cyclooxygenase Inhibitors -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Prostaglandin-Endoperoxide Synthases -- metabolism KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Gastrointestinal Diseases -- chemically induced KW - Isoenzymes -- metabolism KW - Cyclooxygenase Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70812865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Do+cyclooxygenase-2+inhibitors+provide+benefits+similar+to+those+of+traditional+nonsteroidal+anti-inflammatory+drugs%2C+with+less+gastrointestinal+toxicity%3F&rft.au=Feldman%2C+M%3BMcMahon%2C+A+T&rft.aulast=Feldman&rft.aufirst=M&rft.date=2000-01-18&rft.volume=132&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=00034819&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-01-19 N1 - Date created - 2000-01-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Ann Intern Med 2000 Jun 20;132(12):1011 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Creating Interpretation Guidelines for the Hebrew Trail Making Test AN - 85515504; 200113487 AB - The Hebrew language version of the Trail Making Test (TMT; Army Individual Test Battery, 1944) was administered to a group of normal control participants as well as a sample of outpatients approximately 1 year following a head injury. A ratio of TMT-B to TMT-A performance was computed in an effort to establish usable cutting scores for the Hebrew TMT. A ratio of 2.26 was observed to result in 63% sensitivity & 77% specificity for the sample, with positive predictive power of 71% & negative predictive power of 70%. A more stringent cutoff of 3.09 reduced sensitivity (22%) & negative predictive power (44%). In contrast, specificity (97%) & positive predictive power (86%) were greatly improved once the speed of TMT-A performance was also considered. The more conservative cutoff is considered appropriate when a finding is indicative of pathological performance. 14 References. Adapted from the source document JF - Applied Neuropsychology AU - Axelrod, Bradley N AU - Aharon-Peretz, Judith AU - Tomer, Rachel AU - Fisher, Tali AD - Psychology Section, John D. Dingell DVAMC, Detroit, MI bradley.axelrod@med.va.gov Y1 - 2000///0, PY - 2000 DA - 0, 2000 SP - 186 EP - 188 VL - 7 IS - 3 SN - 0908-4282, 0908-4282 KW - Brain Damage (09400) KW - Language Pathology (43250) KW - Measures (Instruments) (52300) KW - Hebrew (31650) KW - article KW - 6910: psychometrics; psychometrics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85515504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Neuropsychology&rft.atitle=Creating+Interpretation+Guidelines+for+the+Hebrew+Trail+Making+Test&rft.au=Axelrod%2C+Bradley+N%3BAharon-Peretz%2C+Judith%3BTomer%2C+Rachel%3BFisher%2C+Tali&rft.aulast=Axelrod&rft.aufirst=Bradley&rft.date=2000-01-01&rft.volume=7&rft.issue=3&rft.spage=186&rft.isbn=&rft.btitle=&rft.title=Applied+Neuropsychology&rft.issn=09084282&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Hebrew (31650); Measures (Instruments) (52300); Brain Damage (09400); Language Pathology (43250) ER - TY - JOUR T1 - Aphasia treatment: a key issue for research into the twenty-first century. AN - 85341458; pmid-10716813 JF - Brain and language AU - Gonzalez Rothi, L J AU - Nadeau, S E AU - Ennis, M R AD - North Florida/South Georgia Veteran's Health System, University of Florida College of Medicine, Gainesville, Florida 32608, USA. gonzalez-rothi.leslie_j@forum.va.gov Y1 - 2000/01// PY - 2000 DA - Jan 2000 SP - 78 EP - 81 VL - 71 IS - 1 SN - 0093-934X, 0093-934X KW - Index Medicus KW - National Library of Medicine KW - Brain -- physiopathology KW - Aphasia -- physiopathology KW - Neuropsychology KW - Humans KW - Forecasting KW - Aphasia -- therapy KW - Research -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85341458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+language&rft.atitle=Aphasia+treatment%3A+a+key+issue+for+research+into+the+twenty-first+century.&rft.au=Gonzalez+Rothi%2C+L+J%3BNadeau%2C+S+E%3BEnnis%2C+M+R&rft.aulast=Gonzalez+Rothi&rft.aufirst=L&rft.date=2000-01-01&rft.volume=71&rft.issue=1&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Brain+and+language&rft.issn=0093934X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Does race make a difference among primary care patients with alcohol problems who agree to enroll in a study of brief interventions? AN - 72537912; 11155785 AB - This study describes the severity, alcohol consumption, consequences, readiness to change, and coping behaviors of African-American and white primary care patients enrolled in a trial of brief interventions for problem drinking. In multivariate analysis, unemployment but not race was associated with clinical indicators of alcohol problems. African-Americans reported no difference in alcohol consumption and similar quality of life scores. African-American race and unemployment were both associated with increased identification and resolution of alcohol problems. There was no difference in readiness to change, but African-Americans reported more problems related to alcohol and greater use of coping behaviors to avoid drinking. African-Americans may be better equipped to manage drinking problems when they do occur due to increased familiarity with coping mechanisms. JF - The American journal on addictions AU - Conigliaro, J AU - Maisto, S A AU - McNeil, M AU - Kraemer, K AU - Kelley, M E AU - Conigliaro, R AU - O'Connor, M AD - Section of General Internal Medicine, Center for Health Services Research, VA Pittsburgh Health Care System, University Drive C, Pittsburgh, PA 15240, USA. joseph.conigliaro@med.va.gov Y1 - 2000 PY - 2000 DA - 2000 SP - 321 EP - 330 VL - 9 IS - 4 SN - 1055-0496, 1055-0496 KW - Index Medicus KW - Motivation KW - Adaptation, Psychological KW - Humans KW - Adult KW - Outcome and Process Assessment (Health Care) KW - Primary Health Care KW - Middle Aged KW - Pennsylvania KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Patient Care Team KW - African Americans -- psychology KW - European Continental Ancestry Group -- psychology KW - Temperance -- psychology KW - Alcoholism -- ethnology KW - Alcoholism -- psychology KW - Psychotherapy, Brief UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72537912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Does+race+make+a+difference+among+primary+care+patients+with+alcohol+problems+who+agree+to+enroll+in+a+study+of+brief+interventions%3F&rft.au=Conigliaro%2C+J%3BMaisto%2C+S+A%3BMcNeil%2C+M%3BKraemer%2C+K%3BKelley%2C+M+E%3BConigliaro%2C+R%3BO%27Connor%2C+M&rft.aulast=Conigliaro&rft.aufirst=J&rft.date=2000-01-01&rft.volume=9&rft.issue=4&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-05 N1 - Date created - 2001-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neural activity related to anger in cocaine-dependent men: a possible link to violence and relapse. AN - 72529958; 11155786 AB - This study examined the neural correlates of cue-induced anger in cocaine-dependent men in an initial investigation of possible neurobiological explanations for the putative association between cocaine addiction and violence. We used positron emission tomography (PET) to localize alterations in regional cerebral blood flow (rCBF) during mental imagery of a personal anger-associated scene and of an emotionally neutral scene in ten cocaine-dependent men. Compared to the emotionally neutral imagery control condition, anger was associated with marked decreases in rCBF in multiple areas of the frontal cortex (particularly the right inferior frontal gyrus), left posterior insula, left fusiform gyrus, and midbrain. Conversely, this same inferior frontal area was activated by anger imagery in nicotine-dependent men. Anger was also associated with increases in rCBF in the right fusiform gyrus, right and left middle occipital gyri, left post-central gyrus, left medial frontal gyrus, left cuneus, and in the left anterior cingulate gyrus. The study showed that cue-induced anger in cocaine-dependent men was associated with decreased activity in frontal cortical areas involved in response monitoring and inhibition. The lack of this association in nicotine-dependent men suggests a possible deficit in anger regulation associated with cocaine dependence and a possible link between cocaine dependence, violence, and relapse. JF - The American journal on addictions AU - Drexler, K AU - Schweitzer, J B AU - Quinn, C K AU - Gross, R AU - Ely, T D AU - Muhammad, F AU - Kilts, C D AD - Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Ga., USA. karen.drexler@med.va.gov Y1 - 2000 PY - 2000 DA - 2000 SP - 331 EP - 339 VL - 9 IS - 4 SN - 1055-0496, 1055-0496 KW - Index Medicus KW - Tobacco Use Disorder -- physiopathology KW - Dominance, Cerebral -- physiology KW - Brain Mapping KW - Tobacco Use Disorder -- diagnostic imaging KW - Humans KW - Adult KW - Tobacco Use Disorder -- psychology KW - Cerebral Cortex -- diagnostic imaging KW - Regional Blood Flow -- physiology KW - Male KW - Imagination -- physiology KW - Cerebral Cortex -- physiopathology KW - Magnetic Resonance Imaging KW - Frontal Lobe -- physiopathology KW - Frontal Lobe -- diagnostic imaging KW - Cocaine-Related Disorders -- psychology KW - Anger -- physiology KW - Cocaine-Related Disorders -- physiopathology KW - Tomography, Emission-Computed KW - Violence -- psychology KW - Cocaine-Related Disorders -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72529958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Neural+activity+related+to+anger+in+cocaine-dependent+men%3A+a+possible+link+to+violence+and+relapse.&rft.au=Drexler%2C+K%3BSchweitzer%2C+J+B%3BQuinn%2C+C+K%3BGross%2C+R%3BEly%2C+T+D%3BMuhammad%2C+F%3BKilts%2C+C+D&rft.aulast=Drexler&rft.aufirst=K&rft.date=2000-01-01&rft.volume=9&rft.issue=4&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-05 N1 - Date created - 2001-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of tacrolimus and mycophenolate mofetil as induction and maintenance in simultaneous pancreas-kidney transplantation. AN - 72472833; 11111994 AB - Clinical trials using quadruple immunosuppression that include the combination of tacrolimus and mycophenolate mofetil have been shown to reduce the incidence of acute rejection episodes in simultaneous pancreas-kidney (SPK) transplantation. In an attempt to obtain a low rejection rate without antibody induction therapy, we undertook a prospective study of combined tacrolimus and mycophenolate mofetil and steroids as primary immunosuppression for SPK transplantation. In this study, we analyzed 17 patients who received low-dose intravenous tacrolimus as induction therapy. This was combined with oral tacrolimus, mycophenolate mofetil, and steroids as the primary immunosuppression regimen. There was a significant reduction of empirically and biopsy-proven rejection with an incidence of 23% (4 patients). Leukopenia, gastroparesis, and gastrointestinal side-effects were the cause of discontinuation of mycophenolate mofetil, or low tacrolimus trough level in those patients who developed rejection. All rejection episodes were easy to treat, and none of them required antibody therapy. The combination of tacrolimus with mycophenolate mofetil without antibody induction therapy is effective in preventing early acute rejection. This combination is safe and effective as an alternative immunosuppressive regimen after SPK transplantation. JF - Transplant international : official journal of the European Society for Organ Transplantation AU - Ciancio, G AU - Lo Monte, A AU - Buscemi, G AU - Miller, J AU - Burke, G W AD - Department of Surgery, University of Miami School of Medicine, and the Miami Veterans Administration Medical Center, FL 33101, USA. gciancio@mednet.med.miami.edu Y1 - 2000 PY - 2000 DA - 2000 SP - S191 EP - S194 VL - 13 Suppl 1 SN - 0934-0874, 0934-0874 KW - Steroids KW - 0 KW - Mycophenolic Acid KW - HU9DX48N0T KW - Tacrolimus KW - WM0HAQ4WNM KW - Index Medicus KW - Steroids -- therapeutic use KW - Drug Therapy, Combination KW - Humans KW - Adult KW - Middle Aged KW - Biopsy KW - Urinary Bladder -- surgery KW - Male KW - Female KW - Tacrolimus -- pharmacokinetics KW - Pancreas Transplantation -- methods KW - Tacrolimus -- therapeutic use KW - Pancreas Transplantation -- immunology KW - Kidney Transplantation -- methods KW - Mycophenolic Acid -- analogs & derivatives KW - Graft Rejection -- diagnosis KW - Mycophenolic Acid -- therapeutic use KW - Kidney Transplantation -- immunology KW - Mycophenolic Acid -- adverse effects KW - Graft Rejection -- prevention & control KW - Graft Rejection -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72472833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplant+international+%3A+official+journal+of+the+European+Society+for+Organ+Transplantation&rft.atitle=Use+of+tacrolimus+and+mycophenolate+mofetil+as+induction+and+maintenance+in+simultaneous+pancreas-kidney+transplantation.&rft.au=Ciancio%2C+G%3BLo+Monte%2C+A%3BBuscemi%2C+G%3BMiller%2C+J%3BBurke%2C+G+W&rft.aulast=Ciancio&rft.aufirst=G&rft.date=2000-01-01&rft.volume=13+Suppl+1&rft.issue=&rft.spage=S191&rft.isbn=&rft.btitle=&rft.title=Transplant+international+%3A+official+journal+of+the+European+Society+for+Organ+Transplantation&rft.issn=09340874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improving medication administration error reporting systems. Why do errors occur? AN - 72209397; 11067442 AB - Monitoring medication administration errors (MAE) is often included as part of the hospital's risk management program. While observation of actual medication administration is the most accurate way to identify errors, hospitals typically rely on voluntary incident reporting processes. Although incident reporting systems are more economical than other methods of error detection, incident reporting can also be a time-consuming process depending on the complexity or "user-friendliness" of the reporting system. Accurate incident reporting systems are also dependent on the ability of the practitioner to: 1) recognize an error has actually occurred; 2) believe the error is significant enough to warrant reporting; and 3) overcome the embarrassment of having committed a MAE and the fear of punishment for reporting a mistake (either one's own or another's mistake). JF - Ambulatory outreach AU - Wakefield, B J AU - Wakefield, D S AU - Uden-Holman, T AD - Iowa City VA Medical Center, and College of Nursing, at The University of Iowa, in Iowa City, IA, USA. bonnie.wakefield@med.va.gov Y1 - 2000 PY - 2000 DA - 2000 SP - 16 EP - 20 SN - 1094-6829, 1094-6829 KW - Health administration KW - United States KW - Humans KW - Total Quality Management KW - Organizational Culture KW - Surveys and Questionnaires KW - Pharmacists KW - Risk Management -- organization & administration KW - Adverse Drug Reaction Reporting Systems -- standards KW - Medication Errors -- prevention & control KW - Medication Systems, Hospital -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72209397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ambulatory+outreach&rft.atitle=Improving+medication+administration+error+reporting+systems.+Why+do+errors+occur%3F&rft.au=Wakefield%2C+B+J%3BWakefield%2C+D+S%3BUden-Holman%2C+T&rft.aulast=Wakefield&rft.aufirst=B&rft.date=2000-01-01&rft.volume=&rft.issue=&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Ambulatory+outreach&rft.issn=10946829&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-19 N1 - Date created - 2000-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Routine hospital alcohol detoxification practice compared to symptom triggered management with an Objective Withdrawal Scale (CIWA-Ar). AN - 71754993; 10934575 AB - Charts of patients hospitalized for uncomplicated alcohol withdrawal were examined and detoxification practices compared. Patients detoxified using a Clinical Institute Withdrawal Assessment for Alcohol-revised (CIWA-Ar) based PRN protocol on the addiction unit received significantly fewer chlordiazepoxide milligram equivalents over shorter duration than patients managed by other detoxification methods on other hospital units. Significantly fewer patients received benzodiazepines in the CIWA-Ar protocol managed group, but inter-group differences (p < 0.01) remained when only medicated patients were compared. Differences between the protocol and non-protocol groups did not reach statistical significance when PRN only strategies were examined, suggesting that the use of a symptom-triggered strategy may account for the noted effects. JF - The American journal on addictions AU - Reoux, J P AU - Miller, K AD - VA Puget Sound Health Care System, Seattle, Wash. 98108, USA. joe.reoux@med.va.gov Y1 - 2000 PY - 2000 DA - 2000 SP - 135 EP - 144 VL - 9 IS - 2 SN - 1055-0496, 1055-0496 KW - Oxazepam KW - 6GOW6DWN2A KW - Chlordiazepoxide KW - 6RZ6XEZ3CR KW - Index Medicus KW - Washington KW - Length of Stay KW - Humans KW - Adult KW - Outcome and Process Assessment (Health Care) KW - Aged KW - Middle Aged KW - Chlordiazepoxide -- administration & dosage KW - Oxazepam -- administration & dosage KW - Male KW - Female KW - Hospitals, Veterans KW - Alcoholism -- rehabilitation KW - Hospitalization KW - Neurologic Examination -- drug effects KW - Alcohol Withdrawal Delirium -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71754993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Routine+hospital+alcohol+detoxification+practice+compared+to+symptom+triggered+management+with+an+Objective+Withdrawal+Scale+%28CIWA-Ar%29.&rft.au=Reoux%2C+J+P%3BMiller%2C+K&rft.aulast=Reoux&rft.aufirst=J&rft.date=2000-01-01&rft.volume=9&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-03 N1 - Date created - 2001-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment of bipolar I disorder in an adolescent with olanzapine. AN - 71273310; 10933124 AB - Bipolar I disorder is estimated to affect 0.6% of adolescents. Lithium, sodium valproate, carbamazapine, and adjunctive treatment with benzodiazapines and antipsychotics have been used to treat bipolar I disorders. We report a case of a 17-year-old adolescent male with bipolar I disorder who responded favorably to the treatment with the atypical antipsychotic olanzapine. We hypothesize that olanzapine's broad affinity for both dopaminergic and serotonergic receptors may be related to the beneficial therapeutic outcome. JF - Journal of child and adolescent psychopharmacology AU - Khouzam, H R AU - El-Gabalawi, F AD - Department of Psychiatry, VAMC, Manchester, New Hampshire 03104-4098, USA. Khouzam.Hani@Manchester.VA.Gov Y1 - 2000 PY - 2000 DA - 2000 SP - 147 EP - 151 VL - 10 IS - 2 SN - 1044-5463, 1044-5463 KW - Antimanic Agents KW - 0 KW - Antipsychotic Agents KW - Benzodiazepines KW - 12794-10-4 KW - Pirenzepine KW - 3G0285N20N KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Humans KW - Antimanic Agents -- adverse effects KW - Antimanic Agents -- therapeutic use KW - Adolescent KW - Male KW - Pirenzepine -- analogs & derivatives KW - Antipsychotic Agents -- therapeutic use KW - Bipolar Disorder -- drug therapy KW - Bipolar Disorder -- psychology KW - Pirenzepine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71273310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+child+and+adolescent+psychopharmacology&rft.atitle=Treatment+of+bipolar+I+disorder+in+an+adolescent+with+olanzapine.&rft.au=Khouzam%2C+H+R%3BEl-Gabalawi%2C+F&rft.aulast=Khouzam&rft.aufirst=H&rft.date=2000-01-01&rft.volume=10&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Journal+of+child+and+adolescent+psychopharmacology&rft.issn=10445463&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-09 N1 - Date created - 2001-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Endothelial cell oxidant production: effect of NADPH oxidase inhibitors. AN - 71217279; 10865939 AB - The effects of known leukocyte NADPH oxidase inhibitors on general cellular oxidant production in cultured human endothelial cells (EC) has been investigated. EC were stimulated with 10 nM phorbol 12-myristate 13-acetate and cellular oxidant production measured in the presence and absence of inhibitors that act on various substituents of the oxidase complex and its activation pathways. The effects of the cytosolic oxidase subunit translocation inhibitors, catechols (3,4-dihydroxybenzaldehyde, caffeic acid, and protocatechuic acid), ortho-methoxy-substituted catechols (apocynin, vanillin, and 4-nitroguaiacol), and quinone, 1,4-naphthoquinone; flavoprotein inhibitors, diphenylene iodonium and quinacrine; haem ligands, imidazole and pyridine; directly acting thiol reagents, disulfiram and penicillamine; NADPH analogue, Cibacron Blue; redox active inhibitors, quercetin and esculetin; intracellular calcium antagonist, TMB-8; and calmodulin antagonists, W-7 and trifluoperazine, were determined. All compounds reduced oxidant production in stimulated EC. These findings add to previous observations suggesting the presence of a functionally active NADPH oxidase in EC. Identifying the major cellular reactive oxygen species source in perturbed EC will provide new insights into our understanding of endothelial dysfunction, which has been hypothesized to be a major contributing factor in the pathogenesis of atherosclerosis. JF - Endothelium : journal of endothelial cell research AU - Holland, J A AU - O'Donnell, R W AU - Chang, M M AU - Johnson, D K AU - Ziegler, L M AD - Department of Biology, State University of New York College at Geneseo, 14454, USA. james.holland3@med.va.gov Y1 - 2000 PY - 2000 DA - 2000 SP - 109 EP - 119 VL - 7 IS - 2 SN - 1062-3329, 1062-3329 KW - Antioxidants KW - 0 KW - Calcium Channel Blockers KW - Enzyme Inhibitors KW - Flavoproteins KW - Fluorescent Dyes KW - Oxidants KW - Reactive Oxygen Species KW - Sulfhydryl Reagents KW - Heme KW - 42VZT0U6YR KW - Hydrogen Peroxide KW - BBX060AN9V KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Calcium-Calmodulin-Dependent Protein Kinases KW - EC 2.7.11.17 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Umbilical Veins -- metabolism KW - Reactive Oxygen Species -- metabolism KW - Oxidation-Reduction -- drug effects KW - Humans KW - Hydrogen Peroxide -- metabolism KW - Heme -- antagonists & inhibitors KW - Calcium Channel Blockers -- pharmacology KW - Cells, Cultured KW - Calcium-Calmodulin-Dependent Protein Kinases -- antagonists & inhibitors KW - Signal Transduction -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Sulfhydryl Reagents -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Umbilical Veins -- drug effects KW - Flavoproteins -- antagonists & inhibitors KW - Umbilical Veins -- enzymology KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- enzymology KW - Endothelium, Vascular -- drug effects KW - Antioxidants -- pharmacology KW - NADPH Oxidase -- antagonists & inhibitors KW - Oxidants -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71217279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endothelium+%3A+journal+of+endothelial+cell+research&rft.atitle=Endothelial+cell+oxidant+production%3A+effect+of+NADPH+oxidase+inhibitors.&rft.au=Holland%2C+J+A%3BO%27Donnell%2C+R+W%3BChang%2C+M+M%3BJohnson%2C+D+K%3BZiegler%2C+L+M&rft.aulast=Holland&rft.aufirst=J&rft.date=2000-01-01&rft.volume=7&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Endothelium+%3A+journal+of+endothelial+cell+research&rft.issn=10623329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-04 N1 - Date created - 2000-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment of depressive mood in schizophrenia with the atypical antipsychotic quetiapine. AN - 71108969; 10812533 AB - Two patients with schizophrenia and depressive mood experienced remission in both their psychotic and depressive symptoms during treatment with the atypical antipsychotic quetiapine. These case reports illustrate the antipsychotic clinical efficacy of quetiapine and its antidepressant effects in the treatment of patients with schizophrenia and depressive mood. JF - Depression and anxiety AU - Khouzam, H R AD - VA Medical Center, Manchester, NH 03104-4098, USA. Khouzam.Hani@Manchester.VA.Gov Y1 - 2000 PY - 2000 DA - 2000 SP - 80 EP - 82 VL - 11 IS - 2 SN - 1091-4269, 1091-4269 KW - Antipsychotic Agents KW - 0 KW - Dibenzothiazepines KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Humans KW - Adult KW - Veterans -- psychology KW - Treatment Outcome KW - Male KW - Dibenzothiazepines -- adverse effects KW - Depression -- psychology KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenia -- diagnosis KW - Schizophrenic Psychology KW - Depression -- drug therapy KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects KW - Dibenzothiazepines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71108969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+anxiety&rft.atitle=Treatment+of+depressive+mood+in+schizophrenia+with+the+atypical+antipsychotic+quetiapine.&rft.au=Khouzam%2C+H+R&rft.aulast=Khouzam&rft.aufirst=H&rft.date=2000-01-01&rft.volume=11&rft.issue=2&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Depression+and+anxiety&rft.issn=10914269&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-07-24 N1 - Date created - 2000-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tardive dyskinesia: pathophysiology and animal models. AN - 71000116; 10739324 AB - Tardive dyskinesia stimulated extensive research into the mechanisms of antipsychotic drug action. A wide range of homologous, analogous, and correlational animal models have been developed to explore how typical neuroleptic drugs do and atypical antipsychotic agents do not seem to cause tardive dyskinesia. The leading hypotheses of the underlying pathophysiology of tardive dyskinesia include dopamine receptor hypersensitivity, GABA insufficiency, and/or structural abnormalities. All these hypotheses have data both for and against them. The roles of psychosis and aging must also be considered in any explanation of tardive dyskinesia. The challenge still remains of how to accurately attribute the relative contributions of each of these factors to the pathogenesis and pathophysiology of tardive dyskinesia. Fortunately, the atypical antipsychotic agents appear to greatly decrease the liability of developing tardive dyskinesia, but how this occurs remains an open and fascinating line of inquiry. JF - The Journal of clinical psychiatry AU - Casey, D E AD - Mental Illness Research, Education and Clinical Center, Veterans Affairs Medical Center, Portland, OR 97201, USA. daniel.casey@med.va.gov Y1 - 2000 PY - 2000 DA - 2000 SP - 5 EP - 9 VL - 61 Suppl 4 SN - 0160-6689, 0160-6689 KW - Antipsychotic Agents KW - 0 KW - Receptors, Dopamine KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Haloperidol KW - J6292F8L3D KW - Index Medicus KW - Neurotoxicity Syndromes -- diagnosis KW - Animals KW - Haloperidol -- therapeutic use KW - Age Factors KW - Humans KW - gamma-Aminobutyric Acid -- physiology KW - Neurotoxicity Syndromes -- physiopathology KW - Basal Ganglia -- anatomy & histology KW - Rats KW - Behavior, Animal -- drug effects KW - Receptors, Dopamine -- physiology KW - Rats, Sprague-Dawley KW - Haloperidol -- pharmacology KW - Mastication -- drug effects KW - Psychotic Disorders -- physiopathology KW - Psychotic Disorders -- drug therapy KW - Antipsychotic Agents -- therapeutic use KW - Dyskinesia, Drug-Induced -- diagnosis KW - Disease Models, Animal KW - Dyskinesia, Drug-Induced -- etiology KW - Dyskinesia, Drug-Induced -- physiopathology KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71000116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Tardive+dyskinesia%3A+pathophysiology+and+animal+models.&rft.au=Casey%2C+D+E&rft.aulast=Casey&rft.aufirst=D&rft.date=2000-01-01&rft.volume=61+Suppl+4&rft.issue=&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-07 N1 - Date created - 2000-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuropeptide Y blocks anxiogenic-like behavioral action of corticotropin-releasing factor in an operant conflict test and elevated plus maze. AN - 70954251; 10704717 AB - Central administration of neuropeptide Y (NPY) produces anxiolytic-like behavioral effects in rat models of anxiety. Because previous evidence has suggested a relationship between NPY and corticotropin-releasing factor (CRF) in the brain, we have focused on the interaction of these neuropeptide systems in emotional responsiveness to stressful stimuli. Intracerebroventricular administration of CRF produced a marked response suppression in an operant incremental shock conflict paradigm. NPY [(1 microg, intracerebroventricularly (i.c.v.)] significantly antagonized the response-suppressing effects of CRF (0.75 microg, i.c.v.) on punished responding in the conflict test at doses that produced little or no behavioral effect when administered alone. Central administration of the CRF antagonist [D-Phe(12), Nle(21,38),C(alpha) MeLeu(37)]CRF (D-Phe CRF(12-41)) alone did not alter punished or unpunished responding in the conflict test. However, pretreatment with the CRF antagonist before a subthreshold dose of NPY (1 microg, i.c.v.) produced a significant potentiation of the release of punished responding relative to NPY alone and untreated controls. NPY also antagonized the "anxiogenic-like" behavioral effects of CRF in the elevated plus maze. These findings support the hypothesis that NPY and CRF may reciprocally modulate an animal's behavioral response to stressful stimuli. JF - Peptides AU - Britton, K T AU - Akwa, Y AU - Spina, M G AU - Koob, G F AD - Department of Psychiatry, San Diego Veterans Administration Medical Center and University of California at San Diego, San Diego, CA, USA. kbritton@ucsd.edu Y1 - 2000/01// PY - 2000 DA - January 2000 SP - 37 EP - 44 VL - 21 IS - 1 SN - 0196-9781, 0196-9781 KW - H-R corticotropin-releasing factor (12-41), Phe(12)-Nle(21,38), C(alpha-MeLeu(37))- KW - 0 KW - Neuropeptide Y KW - Peptide Fragments KW - phenylalanyl corticotropin-releasing factor (12-41) KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - Index Medicus KW - Rats KW - Animals KW - Maze Learning -- drug effects KW - Drug Interactions KW - Conflict (Psychology) KW - Maze Learning -- physiology KW - Dose-Response Relationship, Drug KW - Rats, Wistar KW - Peptide Fragments -- administration & dosage KW - Male KW - Injections, Intraventricular KW - Anxiety -- psychology KW - Corticotropin-Releasing Hormone -- physiology KW - Anxiety -- chemically induced KW - Neuropeptide Y -- pharmacology KW - Corticotropin-Releasing Hormone -- antagonists & inhibitors KW - Corticotropin-Releasing Hormone -- analogs & derivatives KW - Neuropeptide Y -- physiology KW - Corticotropin-Releasing Hormone -- administration & dosage KW - Corticotropin-Releasing Hormone -- pharmacology KW - Neuropeptide Y -- administration & dosage KW - Anxiety -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70954251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Peptides&rft.atitle=Neuropeptide+Y+blocks+anxiogenic-like+behavioral+action+of+corticotropin-releasing+factor+in+an+operant+conflict+test+and+elevated+plus+maze.&rft.au=Britton%2C+K+T%3BAkwa%2C+Y%3BSpina%2C+M+G%3BKoob%2C+G+F&rft.aulast=Britton&rft.aufirst=K&rft.date=2000-01-01&rft.volume=21&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Peptides&rft.issn=01969781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-24 N1 - Date created - 2000-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tolerability and efficacy of nabumetone and naproxen in the treatment of rheumatoid arthritis. AN - 70939949; 10688389 AB - The purpose of this study was to compare the tolerability and efficacy of nabumetone and naproxen in the treatment of patients with rheumatoid arthritis (RA). The occurrence of gastrointestinal (GI) adverse events was compared. Nonsteroidal anti-inflammatory drugs (NSAIDs) have similar efficacy at equipotent doses, but the therapeutic response to various NSAIDs often differs in individual patients. This was a 3-month, randomized, double-blind, multicenter, parallel-group study conducted in adult patients with RA. The study had 2 phases: a 3- to 14-day washout period and a 12-week treatment period. During the treatment phase, the tolerability and efficacy of nabumetone 2000 mg/d were compared with those of naproxen 1000 mg/d. The change from baseline in efficacy variables, including global assessments, number of tender or swollen joints, and pain, was evaluated. The study was sized to provide an 80% power to detect a 15% difference in the percentage improvement on the physician's global assessment (alpha = 0.05). GI safety was assessed by monitoring the occurrence of clinically important adverse GI events. A total of 346 RA patients at 31 US rheumatology centers were randomly assigned to treatment (173 patients per group). The study population was predominantly white (87.0%) and female (70.5%), with a mean age of 54 years. Both treatments improved the signs and symptoms of RA, with no statistically significant differences between groups for any efficacy variables. No serious GI adverse events occurred with either NSAID. The most frequent treatment-related adverse events in both groups were predominantly GI in origin, as were those that resulted in withdrawal from the study. Diarrhea with lower abdominal pain was the most common adverse event in the nabumetone group; upper abdominal pain was the most common adverse event in the naproxen group. The only significant difference between the 2 groups was a higher incidence of diarrhea (P < 0.01) in patients receiving nabumetone. Nabumetone 2000 mg/d was as effective as naproxen 1000 mg/d in relieving the signs and symptoms of RA. In this study, no serious GI adverse events were observed with either NSAID, but nabumetone was associated with a higher incidence of diarrhea. JF - Clinical therapeutics AU - Krug, H AU - Broadwell, L K AU - Berry, M AU - DeLapp, R AU - Palmer, R H AU - Mahowald, M AD - Veterans Administration Medical Center and University of Minnesota, Minneapolis, USA. Y1 - 2000/01// PY - 2000 DA - January 2000 SP - 40 EP - 52 VL - 22 IS - 1 SN - 0149-2918, 0149-2918 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Butanones KW - Naproxen KW - 57Y76R9ATQ KW - nabumetone KW - LW0TIW155Z KW - Index Medicus KW - Double-Blind Method KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Arthritis, Rheumatoid -- drug therapy KW - Naproxen -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Butanones -- therapeutic use KW - Butanones -- administration & dosage KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Naproxen -- administration & dosage KW - Naproxen -- adverse effects KW - Butanones -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70939949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+therapeutics&rft.atitle=Tolerability+and+efficacy+of+nabumetone+and+naproxen+in+the+treatment+of+rheumatoid+arthritis.&rft.au=Krug%2C+H%3BBroadwell%2C+L+K%3BBerry%2C+M%3BDeLapp%2C+R%3BPalmer%2C+R+H%3BMahowald%2C+M&rft.aulast=Krug&rft.aufirst=H&rft.date=2000-01-01&rft.volume=22&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Clinical+therapeutics&rft.issn=01492918&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-16 N1 - Date created - 2000-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intermediate syndrome after malathion ingestion despite continuous infusion of pralidoxime. AN - 70935388; 10696924 AB - A 33-year-old female ingested an unknown quantity of malathion in a suicide attempt. Cholinergic signs consistent with severe organ, phosphate intoxication developed and were treated within 6 hours of ingestion. Intravenous atropine and a continuous infusion of pralidoxime (400 mg/h) were administered. Prolonged depression of plasma and red blood cell cholinesterases were documented. Despite an initial clinical improvement and the presence of plasma pralidoxime concentrations exceeding 4 microg/mL, the patient developed profound motor paralysis consistent with the diagnosis of Intermediate Syndrome. In addition to the dose and frequency of pralidoxime administration, other factors including persistence of organophosphate in the body, the chemical structure of the ingested organophosphate, and the time elapsed between ingestion and treatment may limit the effectiveness of pralidoxime as an antidote in organophosphate ingestions. This case study suggests that these factors should be taken into account in assessing the risk of Intermediate Syndrome after intentional organophosphate ingestions. JF - Journal of toxicology. Clinical toxicology AU - Sudakin, D L AU - Mullins, M E AU - Horowitz, B Z AU - Abshier, V AU - Letzig, L AD - Veterans Administration Medical Center, Oregon Health Science University, Oregon Poison Center, Portland 97201-3098, USA. sudakind@ohsu.edu Y1 - 2000 PY - 2000 DA - 2000 SP - 47 EP - 50 VL - 38 IS - 1 SN - 0731-3810, 0731-3810 KW - Antidotes KW - 0 KW - Cholinesterase Inhibitors KW - Cholinesterase Reactivators KW - Insecticides KW - Pralidoxime Compounds KW - pralidoxime KW - P7MU9UTP52 KW - Malathion KW - U5N7SU872W KW - Abridged Index Medicus KW - Index Medicus KW - Infusions, Intravenous KW - Syndrome KW - Humans KW - Adult KW - Female KW - Malathion -- poisoning KW - Insecticides -- poisoning KW - Cholinesterase Inhibitors -- poisoning KW - Paralysis -- chemically induced KW - Antidotes -- therapeutic use KW - Pralidoxime Compounds -- therapeutic use KW - Cholinesterase Reactivators -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70935388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology.+Clinical+toxicology&rft.atitle=Intermediate+syndrome+after+malathion+ingestion+despite+continuous+infusion+of+pralidoxime.&rft.au=Sudakin%2C+D+L%3BMullins%2C+M+E%3BHorowitz%2C+B+Z%3BAbshier%2C+V%3BLetzig%2C+L&rft.aulast=Sudakin&rft.aufirst=D&rft.date=2000-01-01&rft.volume=38&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology.+Clinical+toxicology&rft.issn=07313810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-03-21 N1 - Date created - 2000-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of TNF- alpha and MnSOD by endotoxin: effect of E5531, a synthetic non-toxic lipid A analog AN - 17816590; 4858745 AB - E5531, a synthetic lipid A analog, has been shown to inhibit endotoxin (lipopolysaccharide, LPS)-induced tumor necrosis factor- alpha (TNF- alpha ) production by human monocytes and murine macrophages. Whether it also inhibits LPS induction of manganese superoxide dismutase (MnSOD) is not clear. In the current study, we demonstrated that E5531, while having no effect on TNF- alpha and MnSOD mRNAs by itself, markedly inhibited LPS- and lipid A-, but not TNF- alpha , induced increases in TNF- alpha and MnSOD mRNAs in human monocytes. In contrast, E5531 at concentrations and conditions that markedly inhibit LPS-induced increases in TNF- alpha and MnSOD mRNAs, and TNF- alpha production by human monocytes, had no effect on murine peritoneal macrophages. These results demonstrate that E5531 is a potent LPS antagonist in human monocytes. However, it does not show antagonist action against LPS in murine macrophages in the range of concentrations tested, suggesting that E5531 is a more potent antagonist in humans than in mice. JF - Journal of Endotoxin Research AU - White, JE AU - Tsan, Min-Fu AD - Research Service (151), Stratton VA Medical Center, 113 Holland Avenue, Albany, NY 12208, USA, min-fu.tsan@med.va.gov Y1 - 2000 PY - 2000 DA - 2000 SP - 329 EP - 335 VL - 6 IS - 4 SN - 0968-0519, 0968-0519 KW - man KW - E-5531 KW - tumor necrosis factor- alpha KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - tumor necrosis factor-a KW - tumor necrosis factor-^a KW - Endotoxins KW - Superoxide dismutase KW - Lipopolysaccharides KW - Monocytes KW - Manganese KW - X 24171:Microbial KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17816590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Endotoxin+Research&rft.atitle=Induction+of+TNF-+alpha+and+MnSOD+by+endotoxin%3A+effect+of+E5531%2C+a+synthetic+non-toxic+lipid+A+analog&rft.au=White%2C+JE%3BTsan%2C+Min-Fu&rft.aulast=White&rft.aufirst=JE&rft.date=2000-01-01&rft.volume=6&rft.issue=4&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Journal+of+Endotoxin+Research&rft.issn=09680519&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lipopolysaccharides; Endotoxins; Monocytes; Manganese; Superoxide dismutase ER - TY - JOUR T1 - Extradural Hemorrhage on the Flight Line: Case Report AN - 17498519; 4692087 AB - Epidural hematoma formation may be expected to occur in 3% of head injuries. The unique pathophysiology of this lesion may complicate early diagnosis, resulting in significant morbidity and mortality if definitive surgical intervention is delayed. Personnel required to work at significant heights servicing large cargo aircraft are certainly at risk for this type of trauma. A case is presented of a traumatic extradural hematoma in a ground aircraft crewman with successful neurosurgical treatment, along with a discussion of the salient features of this potentially lethal traumatic neuropathology. JF - Aviation, Space and Environmental Medicine AU - Keller, T M AU - Griffitt, W E AU - Vowels, J AD - Department of Surgery (Neurosurgery), Veteran's Administration Clinic, 150 Muir Road, Martinez, CA 94553, USA, Keller.thomas.mcneese@martinez.va.gov Y1 - 2000/01// PY - 2000 DA - Jan 2000 SP - 65 EP - 67 VL - 71 IS - 1 SN - 0095-6562, 0095-6562 KW - Epidural hematoma KW - Health & Safety Science Abstracts KW - Accidents KW - Injuries KW - Aircraft KW - Occupational safety KW - Maintenance KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17498519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aviation%2C+Space+and+Environmental+Medicine&rft.atitle=Extradural+Hemorrhage+on+the+Flight+Line%3A+Case+Report&rft.au=Keller%2C+T+M%3BGriffitt%2C+W+E%3BVowels%2C+J&rft.aulast=Keller&rft.aufirst=T&rft.date=2000-01-01&rft.volume=71&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Aviation%2C+Space+and+Environmental+Medicine&rft.issn=00956562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Aircraft; Maintenance; Accidents; Injuries; Occupational safety ER - TY - JOUR T1 - Gabapentin-induced anorgasmia. AN - 69365691; 10599814 JF - Neurology AU - Clark, J D AU - Elliott, J AD - Department of Anesthesiology, Palo Alto Veterans Administration, Health Care System, Stanford University, CA 94304, USA. Y1 - 1999/12/10/ PY - 1999 DA - 1999 Dec 10 SP - 2209 VL - 53 IS - 9 SN - 0028-3878, 0028-3878 KW - Acetates KW - 0 KW - Amines KW - Analgesics KW - Cyclohexanecarboxylic Acids KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - gabapentin KW - 6CW7F3G59X KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Middle Aged KW - Male KW - Orgasm -- drug effects KW - Neuralgia -- drug therapy KW - Acetates -- adverse effects KW - Thoracotomy KW - Acetates -- administration & dosage KW - Pain, Postoperative -- drug therapy KW - Analgesics -- administration & dosage KW - Analgesics -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69365691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Gabapentin-induced+anorgasmia.&rft.au=Clark%2C+J+D%3BElliott%2C+J&rft.aulast=Clark&rft.aufirst=J&rft.date=1999-12-10&rft.volume=53&rft.issue=9&rft.spage=2209&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-01-04 N1 - Date created - 2000-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Psychometrically Equivalent Spondaic Words Spoken by a Female Speaker AN - 85524216; 200104187 AB - Thresholds for the 36 CID W-1 spondaic words were equated psychometrically in two experiments. In the first experiment, adult subjects with normal hearing (N = 20) were used to obtain psychometric functions for two recordings, the original CID recording & a Veterans Administration (VA) recording. Individual word threshold variability was determined for both recordings. Threshold data from experiment one was used in experiment two to digitally equate the spondaic words of the VA recording for intelligibility. Psychometric functions were then obtained with a different group of adults with normal hearing (N = 20) using the spondaic words previously equated for intelligibility. The interword standard deviation was reduced from 1.6 dB to 0.7 dB. Spondaic words on the VA Speech Recognition & Identification Materials compact disc (Disc 2.0) now consist of words whose levels peak at 0 vu & words whose levels have been adjusted for equal intelligibility for persons with normal hearing. 4 Tables, 9 Figures, 12 References. D. Taylor JF - Journal of Speech, Language, and Hearing Research AU - Wilson, Richard H AU - Strouse, Anne AD - Veterans Affairs Medical Center Audiology, Mountain Home, TN richard.wilson2@med.va.gov Y1 - 1999/12// PY - 1999 DA - December 1999 SP - 1336 EP - 1346 VL - 42 IS - 6 SN - 1092-4388, 1092-4388 KW - Auditory Thresholds (06150) KW - Speech Perception (82700) KW - Psychometric Analysis (69210) KW - Auditory Perception (05800) KW - Words (98400) KW - article KW - 6310: hearing-pathological and normal; hearing-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85524216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=Psychometrically+Equivalent+Spondaic+Words+Spoken+by+a+Female+Speaker&rft.au=Wilson%2C+Richard+H%3BStrouse%2C+Anne&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=1999-12-01&rft.volume=42&rft.issue=6&rft.spage=1336&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Psychometric Analysis (69210); Speech Perception (82700); Auditory Perception (05800); Words (98400); Auditory Thresholds (06150) ER - TY - JOUR T1 - The Effectiveness of the Speech Enhancer AN - 85494758; 200005671 AB - This study assessed the processing abilities of speakers with Parkinson's disease who were rated as mildly to moderately impaired (using the Hoehn & Yahr Scale) by recording their responses to speech tasks under delayed auditory feedback. Speakers (N = 10 speakers with Parkinson's disease, 10 matched normal geriatric speakers, & 10 young adults) were recorded under three delayed auditory feedback conditions (no delayed auditory feedback, delay of 125 msec, & delay of 231 msec) while they read, described pictures, or provided spontaneous speech samples. Speech rate, articulation rate, fluency, & intelligibility were measured. Introduction of delayed auditory feedback caused the three groups to perform in broadly similar fashions. Delayed auditory feedback disrupted their speech by reducing their speech rate, articulation rate, &, to a lesser extent, their fluency. When reading, the speakers with Parkinson's disease significantly decreased their speech & articulation rates compared to the controls. However, this did not translate into any benefits for the speakers with Parkinson's disease, as their fluency became somewhat worse & their intelligibility did not change. These results imply that the speakers with mild to moderate Parkinson's disease have problems with resource allocation in that they have reduced resources to monitor & produce speech concurrently. They also may be unable to divide their resources to overcome the interference induced by delayed auditory feedback. 4 Tables, 16 References. Adapted from the source document JF - Journal of Medical Speech-Language Pathology AU - Cariski, Denise AU - Rosenbek, Jay AD - Audiology/Speech Pathology Service, Middleton Memorial VA Hospital, Madison, Wisconsin cariski.denise_m@madison.va.gov Y1 - 1999/12// PY - 1999 DA - December 1999 SP - 315 EP - 322 VL - 7 IS - 4 SN - 1065-1438, 1065-1438 KW - Language Therapy (44400) KW - Delayed Auditory Feedback (17900) KW - Language Pathology (43250) KW - Parkinsons Disease (62800) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85494758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Speech-Language+Pathology&rft.atitle=The+Effectiveness+of+the+Speech+Enhancer&rft.au=Cariski%2C+Denise%3BRosenbek%2C+Jay&rft.aulast=Cariski&rft.aufirst=Denise&rft.date=1999-12-01&rft.volume=7&rft.issue=4&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Speech-Language+Pathology&rft.issn=10651438&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSLPEP N1 - SubjectsTermNotLitGenreText - Parkinsons Disease (62800); Language Pathology (43250); Language Therapy (44400); Delayed Auditory Feedback (17900) ER - TY - JOUR T1 - Prospective multivariate analysis of clinical, endoscopic, and histological factors predictive of the development of Barrett's multifocal high-grade dysplasia or adenocarcinoma. AN - 85314384; pmid-10606296 AB - OBJECTIVE: Our goal was a prospective follow-up of Barrett's esophagus to determine what clinical, endoscopic, and histological features at the time of initial diagnosis are predictive of the development of Barrett's adenocarcinoma or multifocal high-grade dysplasia (HGD). METHODS: Newly diagnosed Barrett's esophagus patients were prospectively followed with a standardized endoscopic and bioptic surveillance protocol. Features examined by chi2 and stepwise logistic regression analyses as potential predictors the development of multifocal HGD or adenocarcinoma included age, length of Barrett's segment, hiatal hernia size, severity of dysplasia at diagnosis, severity of dysplasia during surveillance, and type of long-term medical treatment. RESULTS: One hundred-eight Barrett's patients have had follow-up ranging from 12 months to 101 months (mean +/- SD, 39.9+/-20.8 months), for a total of 361.8 patient-years. Overall, five patients developed multifocal HGD and five developed adenocarcinoma. The incidence of adenocarcinoma as well as multifocal HGD was 1 per 71.9 patient-years. Chi2 analysis showed progression to Barrett's multifocal HGD/adenocarcinoma was associated with hiatal hernia (p = 0.02), the length of Barrett's (p = 0.001), the presence of dysplasia at diagnoses (p or =3 cm), and length of Barrett's (p = 0.009, >2 cm). CONCLUSIONS: Endoscopic and histological features of Barrett's esophagus patients at initial diagnosis are predictive of risk of progression to cancer. JF - The American journal of gastroenterology AU - Weston, A P AU - Badr, A S AU - Hassanein, R S AD - The Veterans Administration Medical Center, Kansas City, Missouri, USA. Y1 - 1999/12// PY - 1999 DA - December 1999 SP - 3413 EP - 3419 VL - 94 IS - 12 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Cell Transformation, Neoplastic -- pathology KW - Humans KW - Disease Progression KW - Aged KW - Biopsy KW - Esophagus -- pathology KW - Prospective Studies KW - Risk Factors KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Female KW - Male KW - Adenocarcinoma -- diagnosis KW - Barrett Esophagus -- pathology KW - Esophageal Neoplasms -- diagnosis KW - Precancerous Conditions -- diagnosis KW - Barrett Esophagus -- diagnosis KW - Esophagoscopy KW - Precancerous Conditions -- pathology KW - Adenocarcinoma -- pathology KW - Esophageal Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85314384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Prospective+multivariate+analysis+of+clinical%2C+endoscopic%2C+and+histological+factors+predictive+of+the+development+of+Barrett%27s+multifocal+high-grade+dysplasia+or+adenocarcinoma.&rft.au=Weston%2C+A+P%3BBadr%2C+A+S%3BHassanein%2C+R+S&rft.aulast=Weston&rft.aufirst=A&rft.date=1999-12-01&rft.volume=94&rft.issue=12&rft.spage=3413&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-01-15 N1 - SuppNotes - Comment in: Am J Gastroenterol. 1999 Dec;94(12):3395-6 [10606286] N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Prospective multivariate analysis of factors predictive of complete regression of Barrett's esophagus. AN - 85308570; pmid-10606297 AB - OBJECTIVE: Demographic, endoscopic, and histological features of Barrett's esophagus at initial diagnosis were examined for their ability to predict complete endoscopic and histological regression of Barrett's during long-term follow-up. METHODS: Barrett's patients who have been followed up for a minimum of 2 yr and who have had at least two follow-up surveillance examinations were included in the analysis. Complete regression of Barrett's was defined as total disappearance of all tongues and patches of Barrett's epithelium at endoscopy (confirmed with Lugol's iodine) in conjunction with only squamous epithelium on biopsy. Chi2 and stepwise logistic regression analyses were performed on the following clinical, endoscopic, and histological variables with regards to their ability to predict complete Barrett's regression: patient age in years ( or =65), length in cm of Barrett's (2 or =6), presence of a hiatal hernia (yes or no), presence of dysplasia at diagnosis (yes or no), and type of long-term medical treatment (histamine antagonists, proton pump inhibitor [PPI], or PPI and cisapride). RESULTS: Ninety-nine patients, all men with a mean age +/- SD in years of 61.6+/-13.1 have been followed prospectively for 24-106 months (mean +/- SD, 48.0+/-19.8). Seven patients have had complete regression of Barrett's. Univariate analysis showed that complete regression of Barrett's was associated only with absence of a hiatal hernia (p = 0.012). Stepwise logistic regression analysis revealed that complete regression was significantly and independently associated again only with absence of a hiatal hernia (p = 0.025). Stepwise logistic regression analysis utilizing only hiatal hernia (yes vs no) and length of Barrett's ( or =6 cm) as variables revealed that absence of a hiatal hernia (p = 0.0447) and shorter lengths (<6 cm) of Barrett's (p = 0.0418) were significantly and independently predictive of complete Barrett's regression. CONCLUSIONS: The absence of a hiatal hernia was noted to be the most important factor associated with Barrett's regression. Complete regression of Barrett's esophagus occurs in a minority of patients, primarily in those with no hiatal hernia and shorter lengths of Barrett's epithelium. JF - The American journal of gastroenterology AU - Weston, A P AU - Badr, A S AU - Hassanein, R S AD - The Veterans Administration Medical Center, Kansas City, Missouri 64128-2226, USA. Y1 - 1999/12// PY - 1999 DA - December 1999 SP - 3420 EP - 3426 VL - 94 IS - 12 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Hernia, Hiatal -- pathology KW - Aged KW - Biopsy KW - Esophagoscopy KW - Remission, Spontaneous KW - Multivariate Analysis KW - Esophagitis, Peptic -- pathology KW - Esophagus -- pathology KW - Prospective Studies KW - Aged, 80 and over KW - Adult KW - Follow-Up Studies KW - Middle Aged KW - Epithelium -- pathology KW - Female KW - Male KW - Barrett Esophagus -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85308570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Prospective+multivariate+analysis+of+factors+predictive+of+complete+regression+of+Barrett%27s+esophagus.&rft.au=Weston%2C+A+P%3BBadr%2C+A+S%3BHassanein%2C+R+S&rft.aulast=Weston&rft.aufirst=A&rft.date=1999-12-01&rft.volume=94&rft.issue=12&rft.spage=3420&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-01-15 N1 - SuppNotes - Comment in: Am J Gastroenterol. 1999 Dec;94(12):3395-6 [10606286] N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Potentiation of platinum antitumor effects in human lung tumor xenografts by the angiogenesis inhibitor squalamine: effects on tumor neovascularization. AN - 69399330; 10632372 AB - Squalamine is a novel anti-angiogenic aminosterol that is postulated to inhibit neovascularization by selectively inhibiting the sodium-hydrogen antiporter exchanger. To determine how to most effectively use this agent in patients with cancer, we examined the antitumor effects of squalamine with or without cytotoxic agents in human lung cancer xenografts and correlated these observations with the degree of tumor neovascularization. No direct cytotoxic effects of squalamine against tumor cells were observed in vitro with or without cisplatin. Squalamine was effective in inhibiting the establishment of H460 human tumors in BALBc nude mice but was ineffective in inhibiting the growth of H460, CALU-6, or NL20T-A human tumor xenografts when administered i.p. to mice bearing established tumors. However, when combined with cisplatin or carboplatin, squalamine increased tumor growth delay by > or =1.5-fold in the three human lung carcinoma cell lines compared with cisplatin or carboplatin alone. No enhancement of antitumor activity was observed when squalamine was combined with paclitaxel, vinorelbine, gemcitabine, or docetaxel. Repeated cycles of squalamine plus cisplatin administration delayed H460 tumor growth >8.6-fold. Squalamine plus cisplatin reduced CD31 vessel formation by 25% compared with controls, squalamine alone, or cisplatin alone; however, no inhibition in CD31 vessel formation was observed when squalamine was combined with vinorelbine. These data demonstrate that the combination of squalamine and a platinum analog has significant preclinical antitumor activity against human lung cancer that is related to the anti-angiogenic effects of squalamine. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Schiller, J H AU - Bittner, G AD - William S. Middleton Veterans Administration Hospital and University of Wisconsin Department of Medicine, Madison 53705, USA. jhschill@facstaff.wisc.edu Y1 - 1999/12// PY - 1999 DA - December 1999 SP - 4287 EP - 4294 VL - 5 IS - 12 SN - 1078-0432, 1078-0432 KW - Angiogenesis Inhibitors KW - 0 KW - Cholestanols KW - Carboplatin KW - BG3F62OND5 KW - squalamine KW - F8PO54Z4V7 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Neoplasm Transplantation KW - Animals KW - Humans KW - Cholestanols -- administration & dosage KW - Transplantation, Heterologous KW - Mice, Nude KW - Mice KW - Neovascularization, Pathologic KW - Mice, Inbred BALB C KW - Drug Synergism KW - Carboplatin -- administration & dosage KW - Female KW - Cholestanols -- pharmacology KW - Cisplatin -- administration & dosage KW - Angiogenesis Inhibitors -- pharmacology KW - Lung Neoplasms -- blood supply KW - Lung Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69399330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Potentiation+of+platinum+antitumor+effects+in+human+lung+tumor+xenografts+by+the+angiogenesis+inhibitor+squalamine%3A+effects+on+tumor+neovascularization.&rft.au=Schiller%2C+J+H%3BBittner%2C+G&rft.aulast=Schiller&rft.aufirst=J&rft.date=1999-12-01&rft.volume=5&rft.issue=12&rft.spage=4287&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-02-14 N1 - Date created - 2000-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hypersensitivity reaction to erythromycin. AN - 69391208; 10626100 JF - Cutis AU - Gallardo, M A AU - Thomas, I AD - Dermatology Service, East Orange Veterans Administration Medical Center, New Jersey 07018, USA. Y1 - 1999/12// PY - 1999 DA - December 1999 SP - 375 EP - 376 VL - 64 IS - 6 SN - 0011-4162, 0011-4162 KW - Anti-Bacterial Agents KW - 0 KW - Erythromycin KW - 63937KV33D KW - Index Medicus KW - Humans KW - Adult KW - Urticaria -- chemically induced KW - Male KW - Angioedema -- chemically induced KW - Drug Hypersensitivity -- etiology KW - Erythromycin -- adverse effects KW - Anti-Bacterial Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69391208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cutis&rft.atitle=Hypersensitivity+reaction+to+erythromycin.&rft.au=Gallardo%2C+M+A%3BThomas%2C+I&rft.aulast=Gallardo&rft.aufirst=M&rft.date=1999-12-01&rft.volume=64&rft.issue=6&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Cutis&rft.issn=00114162&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-02-04 N1 - Date created - 2000-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Unexplained thrombosis in HIV-infected patients receiving protease inhibitors: report of seven cases. AN - 69390537; 10625032 JF - The American journal of medicine AU - George, S L AU - Swindells, S AU - Knudson, R AU - Stapleton, J T AD - Department of Internal Medicine, Iowa City Veterans Administration Medical Center, and the University of Iowa College of Medicine, USA. Y1 - 1999/12// PY - 1999 DA - December 1999 SP - 624 EP - 630 VL - 107 IS - 6 SN - 0002-9343, 0002-9343 KW - HIV Protease Inhibitors KW - 0 KW - Nelfinavir KW - HO3OGH5D7I KW - Saquinavir KW - L3JE09KZ2F KW - Ritonavir KW - O3J8G9O825 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Nelfinavir -- adverse effects KW - Risk Factors KW - Humans KW - Adult KW - Saquinavir -- adverse effects KW - Middle Aged KW - Ritonavir -- adverse effects KW - Male KW - Female KW - Venous Thrombosis -- chemically induced KW - HIV Infections -- drug therapy KW - HIV Protease Inhibitors -- therapeutic use KW - HIV Protease Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69390537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Unexplained+thrombosis+in+HIV-infected+patients+receiving+protease+inhibitors%3A+report+of+seven+cases.&rft.au=George%2C+S+L%3BSwindells%2C+S%3BKnudson%2C+R%3BStapleton%2C+J+T&rft.aulast=George&rft.aufirst=S&rft.date=1999-12-01&rft.volume=107&rft.issue=6&rft.spage=624&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-01-21 N1 - Date created - 2000-01-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Does inhaled albuterol improve diaphragmatic contractility in patients with chronic obstructive pulmonary disease? AN - 69339648; 10588606 AB - We tested the hypothesis that the decrease in dyspnea in patients with COPD with inhaled albuterol is in part due to increased diaphragmatic contractility. Eleven patients with COPD inhaled albuterol or placebo in a double-blind randomized manner. Subsequently, dyspnea was measured while patients breathed through inspiratory resistors, and diaphragmatic contractility was quantified during maximal inspiratory efforts and after twitch stimulation of the phrenic nerves. Albuterol produced a decrease in dyspnea (5 +/- 2 to 4 +/- 2 [SD] Borg units, p < 0.01), and increases in maximal transdiaphragmatic pressure (92.4 +/- 37.2 to 102.8 +/- 37.2 cm H(2)O, p < 0.03) and potentiated twitch transdiaphragmatic pressures (21.6 +/- 7.1 to 25.2 +/- 7.6 cm H(2)O, p < 0.02). The decrease in dyspnea correlated with the increases in maximal and twitch transdiaphragmatic pressures: r = -0.64 (p = 0. 04) and r = -0.65 (p = 0.04), respectively. Compared with placebo, albuterol produced an increase in inspiratory capacity (1.87 +/- 0. 71 to 2.26 +/- 0.74 L, p = 0.002), which accounted for the increases in maximal and twitch transdiaphragmatic pressures. The decrease in dyspnea correlated with the increase in inspiratory capacity (r = -0. 62, p = 0.04), but not with the increase in FEV(1) (r = -0.13, p = 0. 72). In conclusion, albuterol relieves dyspnea and enhances respiratory muscle output in patients with COPD primarily by improving the length-tension relationship of the diaphragm rather than by improving its contractility. JF - American journal of respiratory and critical care medicine AU - Hatipoğlu, U AU - Laghi, F AU - Tobin, M J AD - The Division of Pulmonary and Critical Care Medicine, Edward Hines Jr. Veterans Administration Hospital, and Loyola University of Chicago Stritch School of Medicine, Hines, Illinois 60141, USA. Y1 - 1999/12// PY - 1999 DA - December 1999 SP - 1916 EP - 1921 VL - 160 IS - 6 SN - 1073-449X, 1073-449X KW - Adrenergic beta-Agonists KW - 0 KW - Bronchodilator Agents KW - Albuterol KW - QF8SVZ843E KW - Abridged Index Medicus KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Dyspnea -- physiopathology KW - Aged KW - Action Potentials KW - Inspiratory Capacity KW - Forced Expiratory Volume KW - Electric Stimulation KW - Administration, Inhalation KW - Male KW - Lung Compliance KW - Lung Diseases, Obstructive -- physiopathology KW - Albuterol -- administration & dosage KW - Diaphragm -- physiopathology KW - Muscle Contraction -- drug effects KW - Adrenergic beta-Agonists -- administration & dosage KW - Bronchodilator Agents -- adverse effects KW - Lung Diseases, Obstructive -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69339648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Does+inhaled+albuterol+improve+diaphragmatic+contractility+in+patients+with+chronic+obstructive+pulmonary+disease%3F&rft.au=Hatipo%C4%9Flu%2C+U%3BLaghi%2C+F%3BTobin%2C+M+J&rft.aulast=Hatipo%C4%9Flu&rft.aufirst=U&rft.date=1999-12-01&rft.volume=160&rft.issue=6&rft.spage=1916&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-04-03 N1 - Date created - 2000-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mental disorders and mental health treatment among U.S. Department of Veterans Affairs outpatients: the Veterans Health Study. AN - 69334584; 10588406 AB - The authors examined the self-reported presence and treatment of current depressive disorder, posttraumatic stress disorder (PTSD), and alcohol-related disorder in a group of outpatient veterans. Data were obtained from the Veterans Health Study, a longitudinal investigation of male veterans' health. A representative sample of 2,160 outpatients (mean age = 62 years) was drawn from Boston-area U.S. Department of Veterans Affairs (VA) outpatient facilities. The participants completed screening measures for depression, PTSD, and alcohol-related disorder. Mental health treatment was assessed by interviews. The screening criteria for at least one current mental disorder were satisfied by 40% (N = 856) of the patients. Screening rates were 31% (N = 676) for depression, 20% (N = 426) for PTSD, and 12% (N = 264) for alcohol-related disorder. Patients who screened positively for current mental disorders were younger, less likely to be married or employed, and more likely to report traumatic exposure than were those without mental disorders. Of those who met the screening criteria for any of the targeted mental disorders, 68% (N = 579) reported receiving mental health treatment. Younger, Caucasian men and those who reported more traumatic exposure were more likely to report receiving mental health treatment than were others who screened positively for mental disorders. Screening rates of depression and PTSD and rates of mental health treatment were considerably higher among these VA outpatients than among similar patients in primary care in the private sector. Although the VA is currently meeting the mental health care needs of its patients, future fiscal constraints could affect most adversely the treatment of non-Caucasian and older patients and those with a history of traumatic exposure. JF - The American journal of psychiatry AU - Hankin, C S AU - Spiro, A AU - Miller, D R AU - Kazis, L AD - Center for Health Quality, Outcomes, and Economic Research, Health Services Research and Development Center of Excellence, VA Medical Center, Bedford, Mass, USA. hankinc@icon.palo-alto.med.va.gov Y1 - 1999/12// PY - 1999 DA - December 1999 SP - 1924 EP - 1930 VL - 156 IS - 12 SN - 0002-953X, 0002-953X KW - Abridged Index Medicus KW - Index Medicus KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Alcoholism -- diagnosis KW - Humans KW - Hospitals, Veterans -- utilization KW - Longitudinal Studies KW - Depressive Disorder -- epidemiology KW - Veterans -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Depressive Disorder -- diagnosis KW - Middle Aged KW - United States -- epidemiology KW - United States Department of Veterans Affairs -- statistics & numerical data KW - Male KW - Mental Disorders -- diagnosis KW - Ambulatory Care -- statistics & numerical data KW - Mental Disorders -- epidemiology KW - Mental Health Services -- utilization KW - Mental Health Services -- supply & distribution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69334584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Mental+disorders+and+mental+health+treatment+among+U.S.+Department+of+Veterans+Affairs+outpatients%3A+the+Veterans+Health+Study.&rft.au=Hankin%2C+C+S%3BSpiro%2C+A%3BMiller%2C+D+R%3BKazis%2C+L&rft.aulast=Hankin&rft.aufirst=C&rft.date=1999-12-01&rft.volume=156&rft.issue=12&rft.spage=1924&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-12-14 N1 - Date created - 1999-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk factors accelerating cerebral degenerative changes, cognitive decline and dementia AN - 21109294; 11310271 AB - Objectives Factors accelerating cerebral degenerative changes represent potentially modifiable risks for cognitive decline. Putative risk factors accelerating subtle cognitive decline and dementia were correlated with repeated measures of cerebral atrophy, CT densitometry, perfusions and cognitive testing among neurologically and cognitively normative ageing volunteers. Methods Two hundred and twenty-four normative subjects at increased risk for cognitive decline were admitted to the study. Mean entry age was 59.5-15.8 years. Mean follow-up is 4.3-3.1 years. At follow-up, 22 developed subtle cognitive decline (CCSE-3), 19 became demented, eight with vascular type (VAD) and 11 with Alzheimer's type (DAT) and 183 remain cognitively unchanged. Standardized questionnaires, medical, neuropsychological, neurological and blood work examinations were obtained. Cerebral atrophy, tissue densities and perfusions were measured by xenon-enhanced CT. Results After age 60, cerebral atrophy, ventricular enlargement, polio- and leuko-araiosis geometrically increased as perfusions declined. Risk factors accelerating perfusional decline, cerebral atrophy, polio-araiosis and leuko-araiosis (thinning of grey-white matter densities) were: transient ischaemic attacks (TIAs), hypertension, smoking, hyperlipidemia, male gender. At age 71.5-11.9, subtle cognitive decline began, accelerated by TIAs, hypertension and heart disease. Leuko-araiosis began before cognitive decline. TIAs, hypertension and hyperlipidemia correlated with VAD. Excessive cortical perfusional decreases and cerebral atrophy correlated with cognitive decline. Family history of neurodegenerative disease correlated with DAT. Conclusion TIAs, hypertension, hyperlipidemia, smoking and male gender accelerate cerebral degenerative changes, cognitive decline and dementia. JF - International Journal of Geriatric Psychiatry AU - Meyer, John S AU - Rauch, Gaiane M AU - Crawford, Kate AU - Rauch, Ronald A AU - Konno, Shizuko AU - Akiyama, Hisanao AU - Terayama, Yasuo AU - Haque, A AD - Cerebral Blood Flow Laboratory, Veterans Administration Medical Center, jmeyer@bcm.tmc.edu Y1 - 1999/12// PY - 1999 DA - Dec 1999 SP - 1050 EP - 1061 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 14 IS - 12 SN - 0885-6230, 0885-6230 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Age KW - thinning KW - Transient ischemic attack KW - Hyperlipidemia KW - Alzheimer's disease KW - Aging KW - heart diseases KW - Genetics KW - Smoking KW - Risk factors KW - enlargement KW - Dementia disorders KW - Geriatrics KW - Heart diseases KW - Vascular system KW - Densitometry KW - Inventories KW - Perfusion KW - Thinning KW - Neurodegenerative diseases KW - Blood KW - cognitive ability KW - Cognitive ability KW - hypertension KW - Gender KW - Standards KW - Atrophy KW - dementia disorders KW - Hypertension KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21109294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Geriatric+Psychiatry&rft.atitle=Risk+factors+accelerating+cerebral+degenerative+changes%2C+cognitive+decline+and+dementia&rft.au=Meyer%2C+John+S%3BRauch%2C+Gaiane+M%3BCrawford%2C+Kate%3BRauch%2C+Ronald+A%3BKonno%2C+Shizuko%3BAkiyama%2C+Hisanao%3BTerayama%2C+Yasuo%3BHaque%2C+A&rft.aulast=Meyer&rft.aufirst=John&rft.date=1999-12-01&rft.volume=14&rft.issue=12&rft.spage=1050&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Geriatric+Psychiatry&rft.issn=08856230&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Inventories; Age; Perfusion; Transient ischemic attack; Aging; Alzheimer's disease; Hyperlipidemia; Blood; Neurodegenerative diseases; Smoking; Thinning; Cognitive ability; Risk factors; Dementia disorders; Geriatrics; Atrophy; Densitometry; Vascular system; Hypertension; Heart diseases; Genetics; cognitive ability; thinning; enlargement; Gender; hypertension; Standards; dementia disorders; heart diseases ER - TY - JOUR T1 - High-dose isoniazid therapy for isoniazid-resistant murine Mycobacterium tuberculosis infection AN - 17442765; 4652807 AB - The use of isoniazid (INH) for the treatment of INH-resistant Mycobacterium tuberculosis infection has been controversial. The purpose of the present studies was to determine if there is a dose response with INH for INH-susceptible M. tuberculosis Erdman (ATCC 35801), and whether high-dose INH (100 mg/kg of body weight) was more effective than standard-dose INH (25 mg/kg) for therapy of tuberculosis infections caused by INH-resistant mutants of M. tuberculosis Erdman. Six-week-old CD-1 mice were infected with approximately 10 super(7) viable mycobacteria. Early control groups of infected but untreated mice were euthanized by CO sub(2) inhalation 1 week later when treatment was initiated. INH (25, 50, 75, and 100 mg/kg) was given by gavage 5 days/week for 4 weeks. Late control groups of untreated mice and treated mice were sacrificed 2 days after the last dose of drug. Spleens and right lungs were removed aseptically and homogenized, and viable cell counts were determined by titration on 7H10 agar plates. In the next study, INH at 100 mg/kg was compared to INH at 25 mg/kg against an isogenic mutant of M. tuberculosis Erdman (INH MIC, 2 mu g/ml) and the parent strain. This mutant was found to have a mutation in the KatG protein (Phe to Leu at position 183). In the first study, there was no dose response with increasing doses of INH. In the second study, there was no significant difference between the reduction of viable cell counts for mice treated with INH at 100 mg/kg and that for mice treated with INH at 25 mg/kg (parent or INH-resistant mutant). These preliminary results suggest that INH may be useful in combination therapy of M. tuberculosis infections caused by low-level INH-resistant organisms (INH MICs, 0.2 to 5 mu g/ml) and that higher doses of INH are unlikely to be more efficacious than the standard 300-mg/day dose. JF - Antimicrobial Agents & Chemotherapy AU - Cynamon, M H AU - Zhang, Y AU - Harpster, T AU - Cheng, S AU - De Stefano, MS AD - VAMC, 800 Irving Ave, Syracuse, New York 13210, USA, Cynamon.Michael@Syracuse.VA.GOV Y1 - 1999/12// PY - 1999 DA - Dec 1999 SP - 2922 EP - 2924 VL - 43 IS - 12 SN - 0066-4804, 0066-4804 KW - mice KW - Microbiology Abstracts B: Bacteriology KW - Drug resistance KW - Animal models KW - Tuberculosis KW - Antibacterial agents KW - Mutants KW - Mycobacterium tuberculosis KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17442765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=High-dose+isoniazid+therapy+for+isoniazid-resistant+murine+Mycobacterium+tuberculosis+infection&rft.au=Cynamon%2C+M+H%3BZhang%2C+Y%3BHarpster%2C+T%3BCheng%2C+S%3BDe+Stefano%2C+MS&rft.aulast=Cynamon&rft.aufirst=M&rft.date=1999-12-01&rft.volume=43&rft.issue=12&rft.spage=2922&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Tuberculosis; Animal models; Antibacterial agents; Mutants; Drug resistance ER - TY - JOUR T1 - Genetic relatedness among nontypeable pneumococci implicated in sporadic cases of conjunctivitis AN - 17351928; 4640625 AB - Nontypeable Streptococcus pneumoniae is a common cause of epidemic conjunctivitis. A previous molecular fingerprinting study identified a clone of nontypeable pneumococcus that was responsible for a recent outbreak of conjunctivitis. In the present study, we examined the extent to which pneumococci that cause sporadic cases of conjunctivitis are related to this epidemic strain. Using arbitrarily primed BOX-PCR, we have determined that, of 10 nontypeable pneumococci causing sporadic conjunctivitis, 5 were clonal and closely related to a previous outbreak strain, whereas 5 others were genetically diverse. JF - Journal of Clinical Microbiology AU - Barker, J H AU - Musher, D M AU - Silberman, R AU - Phan, H M AU - Watson, DA AD - Department of Veterans Affairs Medical Center, 2002 Holcombe Blvd., Infectious Disease Section (111G), Room 4b-370, Houston TX 77030, USA, daniel.musher@med.va.gov Y1 - 1999/12// PY - 1999 DA - Dec 1999 SP - 4039 EP - 4041 VL - 37 IS - 12 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Genetic relationship KW - Streptococcus pneumoniae KW - Polymerase chain reaction KW - Genotypes KW - Conjunctivitis KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17351928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Genetic+relatedness+among+nontypeable+pneumococci+implicated+in+sporadic+cases+of+conjunctivitis&rft.au=Barker%2C+J+H%3BMusher%2C+D+M%3BSilberman%2C+R%3BPhan%2C+H+M%3BWatson%2C+DA&rft.aulast=Barker&rft.aufirst=J&rft.date=1999-12-01&rft.volume=37&rft.issue=12&rft.spage=4039&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pneumoniae; Genetic relationship; Conjunctivitis; Genotypes; Polymerase chain reaction ER - TY - JOUR T1 - Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis AN - 17414521; 4635426 AB - The human 15-lipoxygenase (15-LO) gene was transfected into rat kidneys in vivo via intra-renal arterial injection. Three days later, acute (passive) or accelerated forms of antiglomerular basement membrane antibody-mediated glomerulonephritis were induced in transfected and nontransfected or sham-transfected controls. Studies of glomerular functions (filtration and protein excretion) and ex vivo glomerular leukotriene B sub(4) biosynthesis at 3 hr, and up to 4 days, after induction of nephritis revealed preservation or normalization of these parameters in transfected kidneys that expressed human 15-LO mRNA and mature protein, but not in contralateral control kidneys or sham-transfected animals. The results provide in vivo-derived data supporting a direct anti-inflammatory role for 15-LO during immune-mediated tissue injury. JF - Proceedings of the National Academy of Sciences, USA AU - Munger, KA AU - Montero, A AU - Fukunaga, M AU - Uda, S AU - Yura, T AU - Imai, E AU - Kaneda, Y AU - Valdivielso, JM AU - Badr, K F AD - Center for Glomerulonephritis, Renal Division, Emory University and Veterans Administration Medical Center, Atlanta, GA 30033 USA, kbadr@emory.edu Y1 - 1999/11/09/ PY - 1999 DA - 1999 Nov 09 SP - 13375 EP - 13380 VL - 96 IS - 23 SN - 0027-8424, 0027-8424 KW - rats KW - man KW - 15-LO gene KW - 15-lipoxygenase KW - leukotriene B4 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Genetics Abstracts KW - Glomerulonephritis KW - Gene transfer KW - Transfection KW - Inflammation KW - G 07401:Rodentia (rats) KW - W 30965:Miscellaneous, Reviews KW - W3 33180:Gene based (protocols, clinical trials, and animal models) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17414521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Transfection+of+rat+kidney+with+human+15-lipoxygenase+suppresses+inflammation+and+preserves+function+in+experimental+glomerulonephritis&rft.au=Munger%2C+KA%3BMontero%2C+A%3BFukunaga%2C+M%3BUda%2C+S%3BYura%2C+T%3BImai%2C+E%3BKaneda%2C+Y%3BValdivielso%2C+JM%3BBadr%2C+K+F&rft.aulast=Munger&rft.aufirst=KA&rft.date=1999-11-09&rft.volume=96&rft.issue=23&rft.spage=13375&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.96.23.13375 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Transfection; Gene transfer; Inflammation; Glomerulonephritis DO - http://dx.doi.org/10.1073/pnas.96.23.13375 ER - TY - JOUR T1 - Overview of trends in the control of cardiac arrhythmia: past and future. AN - 69284052; 10568654 JF - The American journal of cardiology AU - Singh, B N AD - Division of Cardiology, Veterans Administration Medical Center of West Los Angeles and University of California at Los Angeles, 90073, USA. Y1 - 1999/11/04/ PY - 1999 DA - 1999 Nov 04 SP - 3R EP - 10R VL - 84 IS - 9A SN - 0002-9149, 0002-9149 KW - Anti-Arrhythmia Agents KW - 0 KW - Amiodarone KW - N3RQ532IUT KW - Abridged Index Medicus KW - Index Medicus KW - Survival Rate KW - Humans KW - Defibrillators, Implantable KW - Electrocardiography, Ambulatory -- drug effects KW - Tachycardia, Ventricular -- etiology KW - Tachycardia, Ventricular -- drug therapy KW - Tachycardia, Ventricular -- mortality KW - Ventricular Fibrillation -- drug therapy KW - Amiodarone -- therapeutic use KW - Ventricular Fibrillation -- etiology KW - Amiodarone -- adverse effects KW - Ventricular Fibrillation -- mortality KW - Anti-Arrhythmia Agents -- adverse effects KW - Anti-Arrhythmia Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69284052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Overview+of+trends+in+the+control+of+cardiac+arrhythmia%3A+past+and+future.&rft.au=Singh%2C+B+N&rft.aulast=Singh&rft.aufirst=B&rft.date=1999-11-04&rft.volume=84&rft.issue=9A&rft.spage=3R&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-12-01 N1 - Date created - 1999-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Natural killing of xenogeneic cells mediated by the mouse Ly-49D receptor. AN - 70856642; 10528166 AB - NK lymphocytes lyse certain xenogeneic cells without prior sensitization. The receptors by which NK cells recognize xenogeneic targets are largely uncharacterized but have been postulated to possess broad specificity against ubiquitous target ligands. However, previous studies suggest that mouse NK cells recognize xenogeneic targets in a strain-specific manner, implicating finely tuned, complex receptor systems in NK xenorecognition. We speculated that mouse Ly-49D, an activating NK receptor for the MHC I ligand, H2-Dd, might display public specificities for xenogeneic target structures. To test this hypothesis, we examined the lysis of xenogeneic targets by mouse Ly-49D transfectants of the rat NK cell line RNK-16 (RNK. Ly-49D). Of the xenogeneic tumor targets tested, RNK.Ly-49D, but not untransfected RNK-16, preferentially lysed tumor cells derived from Chinese hamsters and lymphoblast targets from rats. Ly-49D-dependent recognition of Chinese hamster cells was independent of target N-linked glycosylation. Mouse Ly-49D also specifically stimulated the natural killing of lymphoblast targets derived from wild-type and MHC-congenic rats of the RT1lv1 and RT1l haplotypes, but not of the RT1c, RT1u, RT1av1, or RT1n haplotypes. These studies demonstrate that Ly-49D can specifically mediate cytotoxicity against xenogeneic cells, and they suggest that Ly-49D may recognize xenogeneic MHC-encoded ligands. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Nakamura, M C AU - Naper, C AU - Niemi, E C AU - Spusta, S C AU - Rolstad, B AU - Butcher, G W AU - Seaman, W E AU - Ryan, J C AD - Department of Medicine, Veterans Administration Medical Center, University of California, San Francisco 94121, USA. marynak@itsa.ucsf.edu Y1 - 1999/11/01/ PY - 1999 DA - 1999 Nov 01 SP - 4694 EP - 4700 VL - 163 IS - 9 SN - 0022-1767, 0022-1767 KW - Antigens, Ly KW - 0 KW - Histocompatibility Antigens KW - Lectins, C-Type KW - Ligands KW - Receptors, Immunologic KW - Receptors, NK Cell Lectin-Like KW - histocompatibility antigens RT, rat KW - Concanavalin A KW - 11028-71-0 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Rats, Inbred Lew KW - Transfection -- immunology KW - Guinea Pigs KW - Humans KW - Histocompatibility Antigens -- genetics KW - Mice KW - Glycosylation KW - Rats, Inbred BN KW - Mice, Inbred BALB C KW - Rats KW - Rats, Inbred F344 KW - Lymphocyte Activation -- genetics KW - Cattle KW - Histocompatibility Antigens -- metabolism KW - Transfection -- genetics KW - Mice, Inbred C57BL KW - CHO Cells KW - Species Specificity KW - Concanavalin A -- pharmacology KW - Cricetinae KW - Receptors, Immunologic -- genetics KW - Cytotoxicity Tests, Immunologic -- methods KW - Receptors, Immunologic -- physiology KW - Receptors, Immunologic -- metabolism KW - Antigens, Ly -- metabolism KW - Cytotoxicity, Immunologic -- genetics KW - Killer Cells, Natural -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70856642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Natural+killing+of+xenogeneic+cells+mediated+by+the+mouse+Ly-49D+receptor.&rft.au=Nakamura%2C+M+C%3BNaper%2C+C%3BNiemi%2C+E+C%3BSpusta%2C+S+C%3BRolstad%2C+B%3BButcher%2C+G+W%3BSeaman%2C+W+E%3BRyan%2C+J+C&rft.aulast=Nakamura&rft.aufirst=M&rft.date=1999-11-01&rft.volume=163&rft.issue=9&rft.spage=4694&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-11-19 N1 - Date created - 1999-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interstitial nephritis, thrombocytopenia, hepatitis, and elevated serum amylase levels in a patient receiving clarithromycin therapy. AN - 70854657; 10525003 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Baylor, P AU - Williams, K AD - Veterans Administration Central California Health Care System, Fresno, California 93703, USA. baylor.peter@fresno.va.gov Y1 - 1999/11// PY - 1999 DA - November 1999 SP - 1350 EP - 1351 VL - 29 IS - 5 SN - 1058-4838, 1058-4838 KW - Anti-Bacterial Agents KW - 0 KW - Amylases KW - EC 3.2.1.- KW - Clarithromycin KW - H1250JIK0A KW - Index Medicus KW - Humans KW - Aged KW - Male KW - Chemical and Drug Induced Liver Injury -- etiology KW - Nephritis, Interstitial -- chemically induced KW - Anti-Bacterial Agents -- adverse effects KW - Thrombocytopenia -- chemically induced KW - Amylases -- blood KW - Clarithromycin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70854657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Interstitial+nephritis%2C+thrombocytopenia%2C+hepatitis%2C+and+elevated+serum+amylase+levels+in+a+patient+receiving+clarithromycin+therapy.&rft.au=Baylor%2C+P%3BWilliams%2C+K&rft.aulast=Baylor&rft.aufirst=P&rft.date=1999-11-01&rft.volume=29&rft.issue=5&rft.spage=1350&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-12-02 N1 - Date created - 1999-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Penetrating Eye Injury in War AN - 17517423; 4698811 AB - The percentage of penetrating eye injuries in war has increased significantly in this century compared with the total number of combat injuries. With the increasing use of fragmentation weapons and possibly laser weapons on the battle-field in the future, the rate of eye injuries may exceed the 13% of the total military injuries found in Operations Desert Storm/Shield. During the Iran-Iraq War (1980-1988), eye injuries revealed that retained foreign bodies and posterior segment injuries have an improved prognosis in future military ophthalmic surgery as a result of modern diagnostic and treatment modalities. Compared with the increasing penetrating eye injuries on the battlefield, advances in ophthalmic surgery are insignificant. Eye armor, such as visors that flip up and down and protect the eyes from laser injury, needs to be developed. Similar eye protection is being developed in civilian sportswear. Penetrating eye injury in the civilian sector is becoming much closer to the military model and is now comparable for several reasons. JF - Military Medicine AU - Biehl, J W AU - Valdez, J AU - Hemady, R K AU - Steidl, S M AU - Bourke, D L AD - Anesthesia Service, Veterans Administration Medical Center, Baltimore, MD, USA Y1 - 1999/11// PY - 1999 DA - Nov 1999 SP - 780 EP - 820 VL - 164 IS - 11 SN - 0026-4075, 0026-4075 KW - Health & Safety Science Abstracts KW - Eye KW - Injuries KW - Occupational safety KW - Military KW - Protective equipment KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17517423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+Medicine&rft.atitle=Penetrating+Eye+Injury+in+War&rft.au=Biehl%2C+J+W%3BValdez%2C+J%3BHemady%2C+R+K%3BSteidl%2C+S+M%3BBourke%2C+D+L&rft.aulast=Biehl&rft.aufirst=J&rft.date=1999-11-01&rft.volume=164&rft.issue=11&rft.spage=780&rft.isbn=&rft.btitle=&rft.title=Military+Medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Injuries; Eye; Military; Protective equipment; Occupational safety ER - TY - JOUR T1 - Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene. AN - 70832474; 10518582 AB - Epileptic seizures are associated with increases in hippocampal excitability, but the mechanisms that render the hippocampus hyperexcitable chronically (in epilepsy) or acutely (in status epilepticus) are poorly understood. Recent evidence suggests that substance P (SP), a peptide that has been implicated in cardiovascular function, inflammatory responses, and nociception, also contributes to hippocampal excitability and status epilepticus, in part by enhancing glutamate release. Here we report that mice with disruption of the preprotachykinin A gene, which encodes SP and neurokinin A, are resistant to kainate excitoxicity. The mice show a reduction in the duration and severity of seizures induced by kainate or pentylenetetrazole, and both necrosis and apoptosis of hippocampal neurons are prevented. Although kainate induced the expression of bax and caspase 3 in the hippocampus of wild-type mice, these critical intracellular mediators of cell death pathways were not altered by kainate injection in the mutant mice. These results indicate that the reduction of seizure activity and the neuroprotection observed in preprotachykinin A null mice are caused by the extinction of a SP/neurokinin A-mediated signaling pathway that is activated by seizures. They suggest that these neurokinins are critical to the control of hippocampal excitability, hippocampal seizures, and hippocampal vulnerability. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Liu, H AU - Cao, Y AU - Basbaum, A I AU - Mazarati, A M AU - Sankar, R AU - Wasterlain, C G AD - Epilepsy Research Laboratory, Veterans Administration Medical Center, Sepulveda, CA 91343, USA. htliu@ucla.edu Y1 - 1999/10/12/ PY - 1999 DA - 1999 Oct 12 SP - 12096 EP - 12101 VL - 96 IS - 21 SN - 0027-8424, 0027-8424 KW - Bax protein, mouse KW - 0 KW - Convulsants KW - Neurotoxins KW - Protein Precursors KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins c-bcl-2 KW - Tachykinins KW - bcl-2-Associated X Protein KW - preprotachykinin KW - Casp3 protein, mouse KW - EC 3.4.22.- KW - Caspase 3 KW - Caspases KW - Pentylenetetrazole KW - WM5Z385K7T KW - Index Medicus KW - Animals KW - Pentylenetetrazole -- pharmacology KW - Microscopy, Video KW - Convulsants -- pharmacology KW - Neurons -- drug effects KW - Proto-Oncogene Proteins -- metabolism KW - Mice KW - Caspases -- metabolism KW - Hippocampus -- drug effects KW - Mice, Knockout KW - In Situ Nick-End Labeling KW - Signal Transduction KW - Hippocampus -- anatomy & histology KW - Seizures -- chemically induced KW - Apoptosis KW - Tachykinins -- genetics KW - Protein Precursors -- physiology KW - Seizures -- genetics KW - Protein Precursors -- genetics KW - Neurotoxins -- pharmacology KW - Tachykinins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70832474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Resistance+to+excitotoxin-induced+seizures+and+neuronal+death+in+mice+lacking+the+preprotachykinin+A+gene.&rft.au=Liu%2C+H%3BCao%2C+Y%3BBasbaum%2C+A+I%3BMazarati%2C+A+M%3BSankar%2C+R%3BWasterlain%2C+C+G&rft.aulast=Liu&rft.aufirst=H&rft.date=1999-10-12&rft.volume=96&rft.issue=21&rft.spage=12096&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-11-24 N1 - Date created - 1999-11-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1984 Apr 5-11;308(5959):561-2 [6143263] Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5286-91 [10220458] Adv Neurol. 1986;44:857-77 [3706027] J Exp Biol. 1986 Sep;124:259-85 [3020147] Adv Exp Med Biol. 1986;203:647-57 [3024465] J Neurosci. 1987 Feb;7(2):369-79 [2880938] Neuron. 1990 Mar;4(3):379-91 [1690565] Trends Pharmacol Sci. 1990 Sep;11(9):379-87 [2238094] Eur J Biochem. 1990 Nov 13;193(3):751-7 [1701145] Neurosci Lett. 1990 Sep 4;117(1-2):74-80 [1705317] Neuron. 1993 Jan;10(1):11-20 [7678964] J Neurochem. 1993 Mar;60(3):952-60 [7679730] Neurobiol Aging. 1993 Jul-Aug;14(4):275-85 [8367009] Neuron. 1993 Oct;11(4):621-32 [8398151] Science. 1993 Oct 29;262(5134):689-95 [7901908] Cell. 1994 Aug 26;78(4):703-11 [8069917] J Neurophysiol. 1994 Sep;72(3):1192-8 [7528792] Trends Neurosci. 1994 Oct;17(10):432-8 [7530882] Neurosci Lett. 1995 Jun 9;192(2):85-8 [7675327] Eur J Neurosci. 1995 Jul 1;7(7):1627-40 [7551189] Br J Pharmacol. 1995 Jul;115(6):1005-12 [7582496] J Neurosci. 1996 Feb 15;16(4):1337-45 [8778285] Neuron. 1996 Sep;17(3):401-11 [8816704] J Comp Neurol. 1996 Mar 11;366(3):516-33 [8907362] J Comp Neurol. 1997 Feb 3;378(1):70-87 [9120055] Nature. 1997 Apr 17;386(6626):721-4 [9109489] J Neurosci Res. 1997 Apr 15;48(2):168-80 [9130145] Neuroreport. 1997 Jul 7;8(9-10):2117-9 [9243595] Nature. 1997 Oct 23;389(6653):865-70 [9349820] J Cell Biol. 1997 Dec 1;139(5):1281-92 [9382873] Brain Res Mol Brain Res. 1997 Oct 15;50(1-2):16-22 [9406913] Nature. 1998 Jan 1;391(6662):43-50 [9422506] Nature. 1998 Jan 29;391(6666):496-9 [9461218] J Biol Chem. 1998 Mar 27;273(13):7770-5 [9516487] Nature. 1998 Mar 26;392(6674):390-4 [9537322] J Neurosci. 1998 Jul 1;18(13):4914-28 [9634557] J Neurophysiol. 1998 Jul;80(1):113-9 [9658033] Science. 1998 Sep 25;281(5385):2027-31 [9748162] Brain Res Mol Brain Res. 1998 Oct 1;60(2):291-5 [9757066] J Neurosci. 1998 Oct 15;18(20):8382-93 [9763481] Eur J Neurosci. 1999 May;11(5):1605-14 [10215913] Nature. 1985 Jun 6-12;315(6019):498-501 [2582270] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparative localization of auditory comprehension by using functional magnetic resonance imaging and cortical stimulation. AN - 85230395; pmid-10507385 AB - OBJECT: The authors previously described a functional magnetic resonance (fMR) imaging task for the localization of auditory comprehension in which focal activation of posterior temporal and inferior frontal regions of the left hemisphere was reliably demonstrated. Because this study was conducted in neurologically normal volunteers, it was not possible to determine whether the activated regions were critical to the performance of language tasks; that is, whether the fMR imaging activations provided a valid measure of language processing. A direct comparison of fMR imaging language activation with cortical stimulation must be completed before it can be used with confidence in presurgical planning, and this comparison is performed in the present study. METHODS: The authors report on a series of 33 consecutive patients who underwent dominant hemisphere resection and in whom fMR imaging mapping of auditory comprehension was performed at the Yale neurosurgical program. In 23 of the 33 patients fMR imaging activation was consistent with the typical results obtained in normal participants in the earlier study. In 16 of these 23 patients language mapping was performed using either intra- or extraoperative cortical stimulation. Cortical stimulation failed to localize language areas in two of the 16 patients. Electrical stimulation that was performed in proximity to the fMR image activations interfered with auditory comprehension, object naming, or speech production in 12 of the remaining 14 patients. Five of the 10 cases in which evocation of reliable fMR imaging activation failed were attributable to technical problems and/or patient head movement. CONCLUSIONS: Cortical stimulation results and fMR imaging findings were consistent in all but two patients. However, the spatial extent of the activation produced by fMR imaging and the spatial extent of stimulation-induced language disruption that was caused by direct cortical stimulation did not always correspond. Problems in defining the extent of activation by both methods are discussed. JF - Journal of Neurosurgery AU - Schlosser, M J AU - Luby, M AU - Spencer, D D AU - Awad, I A AU - McCarthy, G AD - Neuropsychology Laboratory, Veterans Administration Medical Center, West Haven, Connecticut, USA. PY - 1999 SP - 626 EP - 635 VL - 91 IS - 4 SN - 0022-3085, 0022-3085 KW - Auditory Cortex KW - Support, U.S. Gov't, P.H.S. KW - Verbal Behavior KW - Human KW - Child KW - Electric Stimulation KW - Names KW - Cognition KW - Auditory Perception KW - Comparative Study KW - Adult KW - Middle Age KW - Support, Non-U.S. Gov't KW - Support, U.S. Gov't, Non-P.H.S. KW - Case Report KW - Adolescent KW - Speech KW - Magnetic Resonance Imaging KW - Brain Mapping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85230395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurosurgery&rft.atitle=Comparative+localization+of+auditory+comprehension+by+using+functional+magnetic+resonance+imaging+and+cortical+stimulation.&rft.au=Schlosser%2C+M+J%3BLuby%2C+M%3BSpencer%2C+D+D%3BAwad%2C+I+A%3BMcCarthy%2C+G&rft.aulast=Schlosser&rft.aufirst=M&rft.date=1999-10-01&rft.volume=91&rft.issue=4&rft.spage=626&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurosurgery&rft.issn=00223085&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Comparison of hepatic damage from direct injections of iodinated contrast agents and carbon dioxide. AN - 70855658; 10527206 AB - This study guides the choice of contrast agent for localization of portal veins during transjugular intrahepatic portosystemic shunt (TIPS) placement or use in percutaneous transhepatic cholangiography (PTC) by providing gross anatomic and histologic comparison of effects from parenchymal injections of iodinated contrast agents and carbon dioxide. Eighteen New Zealand White rabbits received direct injections of 2-5 mL of either the nonionic contrast agent iohexol 300 mgI or the ionic contrast agent diatrizoate meglumine 60% into one lobe of the liver and the same volume of CO2 into the other lobe. The rabbits were killed at 2-7 days for gross and histologic evaluation of the livers. At the time of injection, the diatrizoate and iohexol sites showed persistent dark discoloration, whereas CO2 sites showed minimal visible changes. On gross examination at death, all diatrizoate sites showed severe scarring and also commonly showed areas of necrosis. CO2 and iohexol sites showed only minimal discoloration and needle-puncture scars (P < .0001). The histologic grade for diatrizoate sites was significantly more severe than paired CO2 sites (P < .016). Iohexol sites showed mild histologic changes similar to paired CO2 sites (P = .375). Iohexol and CO2 produce less severe hepatic damage and are preferred to meglumine diatrizoate for hepatic injection. JF - Journal of vascular and interventional radiology : JVIR AU - Culp, W C AU - Mladinich, C R AU - Hawkins, I F AD - University of Florida Veterans Administration Medical Center, Gainesville, USA. wculp@unmc.edu Y1 - 1999/10// PY - 1999 DA - October 1999 SP - 1265 EP - 1270 VL - 10 IS - 9 SN - 1051-0443, 1051-0443 KW - Contrast Media KW - 0 KW - Carbon Dioxide KW - 142M471B3J KW - Diatrizoate Meglumine KW - 3X9MR4N98U KW - Iohexol KW - 4419T9MX03 KW - Index Medicus KW - Animals KW - Rabbits KW - Male KW - Female KW - Diatrizoate Meglumine -- pharmacology KW - Liver -- pathology KW - Liver -- drug effects KW - Contrast Media -- toxicity KW - Iohexol -- toxicity KW - Iohexol -- pharmacology KW - Portasystemic Shunt, Transjugular Intrahepatic -- methods KW - Contrast Media -- pharmacology KW - Cholangiography -- methods KW - Diatrizoate Meglumine -- toxicity KW - Carbon Dioxide -- pharmacology KW - Carbon Dioxide -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70855658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+vascular+and+interventional+radiology+%3A+JVIR&rft.atitle=Comparison+of+hepatic+damage+from+direct+injections+of+iodinated+contrast+agents+and+carbon+dioxide.&rft.au=Culp%2C+W+C%3BMladinich%2C+C+R%3BHawkins%2C+I+F&rft.aulast=Culp&rft.aufirst=W&rft.date=1999-10-01&rft.volume=10&rft.issue=9&rft.spage=1265&rft.isbn=&rft.btitle=&rft.title=Journal+of+vascular+and+interventional+radiology+%3A+JVIR&rft.issn=10510443&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-11-30 N1 - Date created - 1999-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways. AN - 70036466; 10490998 AB - The proinflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha are produced within the CNS, and, similar to the periphery, they have pleotrophic and overlapping functions. We have shown previously that TNF-alpha increases neuronal survival to a toxic influx of calcium mediated through neuronal N-methyl-d -aspartic acid (NMDA) glutamate-gated ion channels. This process, termed excitotoxicity, is a major contributor to neuronal death following ischemia or stroke. Neuroprotection by this cytokine requires both activation of the p55/TNF receptor type I and the release of TNF-alpha from neurons, and it is inhibited by the plant alkaloid nicotine. Here, we report that other inflammatory cytokines (IL-1 alpha, IL-1 beta, and IL-6) are also neuroprotective to excessive NMDA challenge in our system. Neuroprotection provided by IL-1 is distinct from TNF-alpha because it is inhibited by IL-1 receptor antagonist; it is not antagonized by nicotine, but it is inhibited by a neutralizing Ab to nerve growth factor (NGF). Similar to IL-1, IL-6-mediated neuroprotection is also antagonized by pretreatment with IL-1 receptor antagonist and it is not affected by nicotine. However, neutralizing anti-NGF only partially blocks IL-6-mediated protection. These studies support an important role for distinct but overlapping neuroprotective cytokine effects in the CNS. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Carlson, N G AU - Wieggel, W A AU - Chen, J AU - Bacchi, A AU - Rogers, S W AU - Gahring, L C AD - Geriatric Research Education and Clinical Center, Veterans Administration Medical Center, Salt Lake City, UT 84112, USA. Y1 - 1999/10/01/ PY - 1999 DA - 1999 Oct 01 SP - 3963 EP - 3968 VL - 163 IS - 7 SN - 0022-1767, 0022-1767 KW - Il1rn protein, mouse KW - 0 KW - Immune Sera KW - Interleukin 1 Receptor Antagonist Protein KW - Interleukin-1 KW - Interleukin-6 KW - Nerve Growth Factors KW - Neurotoxins KW - Nicotinic Antagonists KW - Receptors, Interleukin-1 KW - Sialoglycoproteins KW - Tumor Necrosis Factor-alpha KW - N-Methylaspartate KW - 6384-92-5 KW - Nicotine KW - 6M3C89ZY6R KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Nerve Growth Factors -- immunology KW - Neurons -- drug effects KW - Receptors, Interleukin-1 -- antagonists & inhibitors KW - Mice KW - Nerve Growth Factors -- physiology KW - Cerebral Cortex KW - Sialoglycoproteins -- pharmacology KW - Cells, Cultured KW - Nicotine -- pharmacology KW - Neurons -- cytology KW - Nicotinic Antagonists -- pharmacology KW - N-Methylaspartate -- toxicity KW - Inflammation -- immunology KW - Receptors, Interleukin-1 -- physiology KW - Neurons -- immunology KW - Immune Sera -- pharmacology KW - Interleukin-1 -- physiology KW - Interleukin-1 -- metabolism KW - Interleukin-6 -- physiology KW - Signal Transduction -- drug effects KW - Signal Transduction -- immunology KW - Tumor Necrosis Factor-alpha -- physiology KW - Neuroimmunomodulation -- drug effects KW - Neuroimmunomodulation -- immunology KW - Interleukin-1 -- antagonists & inhibitors KW - Neurotoxins -- toxicity KW - Neurotoxins -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70036466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Inflammatory+cytokines+IL-1+alpha%2C+IL-1+beta%2C+IL-6%2C+and+TNF-alpha+impart+neuroprotection+to+an+excitotoxin+through+distinct+pathways.&rft.au=Carlson%2C+N+G%3BWieggel%2C+W+A%3BChen%2C+J%3BBacchi%2C+A%3BRogers%2C+S+W%3BGahring%2C+L+C&rft.aulast=Carlson&rft.aufirst=N&rft.date=1999-10-01&rft.volume=163&rft.issue=7&rft.spage=3963&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-10-21 N1 - Date created - 1999-10-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical characteristics of alcoholism in alcohol-dependent subjects with and without a history of alcohol treatment. AN - 69238713; 10549991 AB - Most clinical alcohol research is carried out on alcoholics who are in treatment, usually inpatients. However, most alcohol-dependent men and women never enter treatment, and even fewer ever receive inpatient care. Thus, some generally accepted data on the clinical course of alcoholism, derived from treatment samples, might not generalize to the entire population of alcohol-dependent individuals. This article characterizes the clinical characteristics of alcohol dependence in three groups of alcoholics, based on their histories of treatment for alcohol problems: those without prior rehabilitation; those with only outpatient approaches or Alcoholics Anonymous (AA); and subjects with an inpatient experience. Semistructured interviews were administered to 3572 DSM-III-R-defined alcohol-dependent subjects from the Collaborative Study on the Genetics of Alcoholism. The clinical patterns were compared across the three groups of alcoholics: Group 1, never-treated (n = 1582; 44%); Group 2, histories of outpatient or AA only (n = 399; 11%); and Group 3, at least one inpatient experience (n = 1591; 45%). A progression was shown from Groups 1 to 3 for more general life problems (e.g., unemployment, marital instability); higher rates of additional drug dependencies and psychiatric disorders; and more alcohol-related adverse events. Logistic regression analyses revealed that those with no prior treatment were more likely to be women, Caucasian, and employed, and to report a lower rate of divorce/separation, lower levels of alcohol intake, and fewer alcohol problems. Among those who received help, inpatient care was predicted by an opposite profile. These results indicate that studies using data from inpatient populations may give a skewed picture of the clinical characteristics of alcohol dependence. JF - Alcoholism, clinical and experimental research AU - Raimo, E B AU - Daeppen, J B AU - Smith, T L AU - Danko, G P AU - Schuckit, M A AD - Department of Psychiatry, University of California, San Diego, and the San Diego Veterans Administration Medical Center, 92161, USA. Y1 - 1999/10// PY - 1999 DA - October 1999 SP - 1605 EP - 1613 VL - 23 IS - 10 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Socioeconomic Factors KW - Regression Analysis KW - Analysis of Variance KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Alcoholics Anonymous KW - Male KW - Female KW - Hospitalization KW - Alcoholism -- therapy KW - Alcoholism -- psychology KW - Ambulatory Care -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69238713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Clinical+characteristics+of+alcoholism+in+alcohol-dependent+subjects+with+and+without+a+history+of+alcohol+treatment.&rft.au=Raimo%2C+E+B%3BDaeppen%2C+J+B%3BSmith%2C+T+L%3BDanko%2C+G+P%3BSchuckit%2C+M+A&rft.aulast=Raimo&rft.aufirst=E&rft.date=1999-10-01&rft.volume=23&rft.issue=10&rft.spage=1605&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-11-30 N1 - Date created - 1999-11-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Alcohol Clin Exp Res. 1999 Oct;23(10):1561-2 [10549985] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differentiating agents regulate cathepsin B gene expression in HL-60 cells. AN - 69210153; 10534117 AB - We utilized HL-60 cells as a model system to examine the regulation of ctsb gene expression by differentiating agents. Inducers of monocytic differentiation [phorbol ester (PMA), calcitriol (D3), and sodium butyrate (NaB)] and inducers of granulocytic differentiation [all-trans retinoic acid (RA) and 9-cis retinoic acid (9-cis RA)] increase ctsb mRNA levels in a dose-dependent manner as determined by Northern blot hybridization. D3 and retinoids exert additive effects, suggesting that these agents act in part through distinct pathways. Actinomycin D decay experiments indicate that D3, NaB, RA, and 9-cis RA do not alter mRNA stability. In contrast, PMA markedly increases the half-life of ctsb mRNA. In transient transfection assays, PMA and NaB both stimulate transcription of the luciferase reporter gene placed under the control of ctsb promoter fragments. Thus, inducers of HL-60 cell differentiation can regulate the expression of the ctsb gene at both transcriptional and posttranscriptional levels. JF - Journal of leukocyte biology AU - Berquin, I M AU - Yan, S AU - Katiyar, K AU - Huang, L AU - Sloane, B F AU - Troen, B R AD - Department of Internal Medicine, and Institute of Gerontology, Geriatric Research Education and Clinical Center, Veterans Administration Medical Center, University of Michigan, Ann Arbor, USA. Y1 - 1999/10// PY - 1999 DA - October 1999 SP - 609 EP - 616 VL - 66 IS - 4 SN - 0741-5400, 0741-5400 KW - Butyrates KW - 0 KW - Mitogens KW - Nucleic Acid Synthesis Inhibitors KW - Protein Synthesis Inhibitors KW - RNA, Messenger KW - Dactinomycin KW - 1CC1JFE158 KW - alitretinoin KW - 1UA8E65KDZ KW - Tretinoin KW - 5688UTC01R KW - Cycloheximide KW - 98600C0908 KW - Cathepsin B KW - EC 3.4.22.1 KW - Calcitriol KW - FXC9231JVH KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Nucleic Acid Synthesis Inhibitors -- pharmacology KW - Dactinomycin -- pharmacology KW - Promoter Regions, Genetic KW - Protein Synthesis Inhibitors -- pharmacology KW - HL-60 Cells KW - Humans KW - Cycloheximide -- pharmacology KW - Transcription, Genetic KW - Cell Differentiation -- drug effects KW - Mitogens -- pharmacology KW - Tretinoin -- pharmacology KW - Butyrates -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Gene Expression Regulation -- drug effects KW - Calcitriol -- pharmacology KW - Cathepsin B -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69210153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+leukocyte+biology&rft.atitle=Differentiating+agents+regulate+cathepsin+B+gene+expression+in+HL-60+cells.&rft.au=Berquin%2C+I+M%3BYan%2C+S%3BKatiyar%2C+K%3BHuang%2C+L%3BSloane%2C+B+F%3BTroen%2C+B+R&rft.aulast=Berquin&rft.aufirst=I&rft.date=1999-10-01&rft.volume=66&rft.issue=4&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Journal+of+leukocyte+biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-11-18 N1 - Date created - 1999-11-18 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - AF086639; GENBANK N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence of Depressive and Alcohol Abuse Symptoms among Women VA Outpatients Who Report Experiencing Sexual Assault While in the Military AN - 61609579; 200011333 AB - Mail questionnaire data from a national sample of 3,632 women Veterans Affairs (VA) outpatients are used to determine self-reported prevalence of sexual assault experienced during military service & compare screening prevalence for current symptoms of depression & alcohol abuse between those who did & did not report this history. Military-related sexual assault was reported by 23% of the women. Screening prevalence for symptoms of current depression was 3 times higher & for current alcohol abuse was 2 times higher among those who reported experiencing military-related sexual assault. Recent mental health treatment was reported by 50% of those who reported experiencing sexual assault during military service & screened positive for symptoms of depression, & by 40% of those who screened positive for symptoms of alcohol abuse. 1 Table, 30 References. Adapted from the source document. JF - Journal of Traumatic Stress AU - Hankin, Cheryl S AU - Skinner, Katherine M AU - Sullivan, Lisa M AU - Miller, Donald R AU - Frayne, Susan AU - Tripp, Tara J AD - HSR&D, Veterans Affairs Medical Center (152), Palo Alto, CA hankinc@icon.palo-alto.med.va.gov Y1 - 1999/10// PY - 1999 DA - October 1999 SP - 601 EP - 612 VL - 12 IS - 4 SN - 0894-9867, 0894-9867 KW - Veterans KW - Outpatients KW - Alcohol Abuse KW - Depression (Psychology) KW - Military Personnel KW - Sexual Assault KW - Victims KW - United States of America KW - Females KW - article KW - 0623: complex organization; military sociology KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61609579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Traumatic+Stress&rft.atitle=Prevalence+of+Depressive+and+Alcohol+Abuse+Symptoms+among+Women+VA+Outpatients+Who+Report+Experiencing+Sexual+Assault+While+in+the+Military&rft.au=Hankin%2C+Cheryl+S%3BSkinner%2C+Katherine+M%3BSullivan%2C+Lisa+M%3BMiller%2C+Donald+R%3BFrayne%2C+Susan%3BTripp%2C+Tara+J&rft.aulast=Hankin&rft.aufirst=Cheryl&rft.date=1999-10-01&rft.volume=12&rft.issue=4&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Journal+of+Traumatic+Stress&rft.issn=08949867&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JTSTEB N1 - SubjectsTermNotLitGenreText - Outpatients; Veterans; Females; United States of America; Depression (Psychology); Alcohol Abuse; Sexual Assault; Victims; Military Personnel ER - TY - CONF T1 - Toxins affecting cell signalling and alteration of cytoskeletal structure AN - 17437812; 4648529 AB - Many natural toxins act by modifying key functions of the phosphorylation-based signalling machinery. Microcystins comprise a good example of highly specific, signalling-targeted toxicants. These liver-specific cyanobacterial peptide toxins act as potent inhibitors of serine/threonine (ser/thr) protein phosphatases, in particular type-1 (PP1) and type-2A (PP2A). PP1 and PP2A regulate the phosphorylation of a large number of key elements in various signalling processes. Furthermore, they are crucial in maintaining cytoskeletal integrity. Consequently, microcystins disrupt the liver structure by abrogating cytoskeletal regulation. Microcystin-induced protein phosphatase inhibition in liver cells leads to rapid reorganization of all three major cytoskeletal components, microfilaments, microtubules and intermediate filaments (IFs). The inhibited dephosphorylation induces an especially marked phosphorylation of the liver IF proteins, keratins 8 and 18. The elevated phosphorylation of these proteins causes disassembly and reorganization of keratin filaments, indicating that their assembly state in vivo is regulated by a continuous phosphate turnover. In this review on microcystin-induced cellular effects, we attempt to illustrate the potentially grave consequences when phosphorylation processes are disturbed by toxicants. The aim is also to show how such signalling-targeted toxicants can be used as biochemical tools to establish the biological roles of specific signalling or regulatory processes. JF - Toxicology In Vitro AU - Toivola, D M AU - Eriksson, I E Y1 - 1999/10// PY - 1999 DA - Oct 1999 SP - 521 EP - 530 PB - Pergamon VL - 13 IS - 4/5 KW - signalling KW - microcystins KW - protein-serine/threonine-phosphatase KW - Toxicology Abstracts KW - Cytoskeleton KW - Microcystis KW - Phosphorylation KW - Toxins KW - X 24172:Plants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17437812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+In+Vitro&rft.atitle=Toxins+affecting+cell+signalling+and+alteration+of+cytoskeletal+structure&rft.au=Toivola%2C+D+M%3BEriksson%2C+I+E&rft.aulast=Toivola&rft.aufirst=D&rft.date=1999-10-01&rft.volume=13&rft.issue=4%2F5&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Toxicology+In+Vitro&rft.issn=08872333&rft_id=info:doi/10.1016%2FS0887-2333%2899%2900024-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1016/S0887-2333(99)00024-7 ER - TY - JOUR T1 - Evaluation of rifapentine in long-term treatment regimens for tuberculosis in mice AN - 17340693; 4615537 AB - Besides direct bactericidal activity, long-term effectiveness is one of the most important features to consider when developing new drugs for chemotherapy. In this study, we evaluated the ability of rifapentine (RFP), in monotherapy and combination therapy, to completely eradicate a Mycobacterium tuberculosis infection and to prevent relapse posttreatment in a Swiss mouse model. The combination of RFP, isoniazid (INH), and pyrazinamide (PZA) administered daily resulted in an apparent clearance of M. tuberculosis organisms in the lungs and spleens of infected mice after 10 weeks of treatment. However, 3 months after the cessation of therapy, bacterial regrowth occurred in mice treated for a 12-week period, indicating a relapse of infection. In intermittent treatment regimens of RFP in combination with INH and PZA, sterilization was achieved when mice were treated two to five times per week for 9 weeks. Bacterial growth was still observed in the once-weekly treatment group. Our results show that mouse models can predict important parameters for new drugs. We stress the necessity for long-term posttreatment observation in animal models for the routine evaluation of new drugs for antituberculosis chemotherapy. JF - Antimicrobial Agents & Chemotherapy AU - Lenaerts, AMJA AU - Chase, ShE AU - Chmielewski, A J AU - Cynamon, M H AD - VAMC, 800 Irving Ave., Syracuse, NY 13210, USA, Cynamon.Michael@syracuse.va.gov Y1 - 1999/10// PY - 1999 DA - Oct 1999 SP - 2356 EP - 2360 VL - 43 IS - 10 SN - 0066-4804, 0066-4804 KW - Pyrazinamide KW - Rifapentine KW - animal models KW - isoniazid KW - long-term effects KW - mice KW - relapses KW - Microbiology Abstracts B: Bacteriology KW - Tuberculosis KW - Antibacterial agents KW - Mycobacterium tuberculosis KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17340693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Evaluation+of+rifapentine+in+long-term+treatment+regimens+for+tuberculosis+in+mice&rft.au=Lenaerts%2C+AMJA%3BChase%2C+ShE%3BChmielewski%2C+A+J%3BCynamon%2C+M+H&rft.aulast=Lenaerts&rft.aufirst=AMJA&rft.date=1999-10-01&rft.volume=43&rft.issue=10&rft.spage=2356&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Antibacterial agents; Tuberculosis ER - TY - JOUR T1 - Nasal administration of the nitric oxide synthase inhibitor L-NAME induces daytime somnolence. AN - 70815136; 10505824 AB - In preliminary studies, human subjects complained of drowsiness after aerosolization of NG-nitro-L-arginine methyl ester (L-NAME) into the nasal passages. We compared the effects of a nasal aerosol of L-NAME (0.5 M, 4 ml) to those of saline on sleep onset latency and exhaled nasal nitric oxide (NO). L-NAME decreased sleep onset latency and exhaled nasal NO. Vasoconstriction and local effects of L-NAME on NO synthesis are unlikely to explain this effect since oxymetazoline, a vasoconstrictor, decreased exhaled NO but had no effect on sleep onset latency. We conclude that aerosolization of L-NAME to the nasal passages induces daytime sleepiness. JF - Sleep AU - Sippel, J M AU - Giraud, G D AU - Holden, W E AD - Portland Veterans Administration Medical Center and Oregon Health Sciences University, 97201, USA. Y1 - 1999/09/15/ PY - 1999 DA - 1999 Sep 15 SP - 786 EP - 788 VL - 22 IS - 6 SN - 0161-8105, 0161-8105 KW - Enzyme Inhibitors KW - 0 KW - Nitric Oxide KW - 31C4KY9ESH KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Index Medicus KW - Circadian Rhythm KW - Humans KW - Administration, Intranasal KW - Electroencephalography KW - Adult KW - Middle Aged KW - Time Factors KW - Male KW - Female KW - NG-Nitroarginine Methyl Ester -- pharmacology KW - Sleep -- drug effects KW - Nitric Oxide -- antagonists & inhibitors KW - Disorders of Excessive Somnolence -- chemically induced KW - Enzyme Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70815136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sleep&rft.atitle=Nasal+administration+of+the+nitric+oxide+synthase+inhibitor+L-NAME+induces+daytime+somnolence.&rft.au=Sippel%2C+J+M%3BGiraud%2C+G+D%3BHolden%2C+W+E&rft.aulast=Sippel&rft.aufirst=J&rft.date=1999-09-15&rft.volume=22&rft.issue=6&rft.spage=786&rft.isbn=&rft.btitle=&rft.title=Sleep&rft.issn=01618105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-11-10 N1 - Date created - 1999-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The antacid Talcid adsorbs and neutralizes all proteins secreted by H. pylori including VacA cytotoxin: a new mechanism for its ulcer-healing action? AN - 70021023; 10473969 AB - Helicobacter pylori culture supernatant containing VacA cytotoxin significantly inhibits gastric cell proliferation and delays healing of experimental gastric ulcers. Since cell proliferation is crucial for ulcer healing, the removal of inhibitory effects of H. pylori secreted cytotoxin would have a beneficial effect on the healing process. In this study, we determined whether the antacid Talcid can adsorb, remove, or neutralize H. pylori derived VacA cytotoxin responsible for the above deleterious actions. Supernatants of viable H. pylori isogenic strains producing VacA cytotoxin [VacA(+)] and with disrupted cytotoxin gene not producing cytotoxin [VacA(-)] were incubated with either placebo, Talcid 10 mg/ml, omeprazole 10 mg/ml (positive control) for 1-24 h. Treated supernatants were analyzed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis to evaluate proteins. We also studied the effect of supernatants on epidermal growth factor stimulated Kato III cell proliferation using BrdU labeling. Talcid very effectively removed from the H. pylori culture supernatant the approximately 90 kD VacA(+) cytotoxin at 3 and 24 h (99.5% removal vs. placebo-treated control; p<0.001). It also removed all other proteins, including 66-kD urease and 58-kD heat shock protein, secreted by both VacA(+) and VacA(-) H. pylori strains. Omeprazole was completely ineffective in this regard. Preincubation with Talcid completely abolished the inhibitory effect of VacA(+) H. pylori culture supernatant on epidermal growth factor stimulated Kato III cell proliferation. Adsorption and neutralization by Talcid of all H. pylori secreted proteins may explain, at least in part, the ulcer-healing action of this drug. JF - Digestion AU - Tarnawski, A AU - Pai, R AU - Itani, R AU - Wyle, F A AD - Veterans Administration Medical Center, Long Beach, Calif. 90822, USA. atarnawski@pop.long-beach.va.gov PY - 1999 SP - 449 EP - 455 VL - 60 IS - 5 SN - 0012-2823, 0012-2823 KW - Antacids KW - 0 KW - Bacterial Proteins KW - Cytotoxins KW - hydrotalcite KW - 17432CG1KU KW - Aluminum Hydroxide KW - 5QB0T2IUN0 KW - Magnesium Hydroxide KW - NBZ3QY004S KW - Index Medicus KW - Analysis of Variance KW - Electrophoresis, Polyacrylamide Gel KW - Cells, Cultured KW - Magnesium Hydroxide -- pharmacology KW - Cytotoxins -- metabolism KW - Antacids -- pharmacology KW - Bacterial Proteins -- metabolism KW - Helicobacter pylori -- metabolism KW - Aluminum Hydroxide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70021023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestion&rft.atitle=The+antacid+Talcid+adsorbs+and+neutralizes+all+proteins+secreted+by+H.+pylori+including+VacA+cytotoxin%3A+a+new+mechanism+for+its+ulcer-healing+action%3F&rft.au=Tarnawski%2C+A%3BPai%2C+R%3BItani%2C+R%3BWyle%2C+F+A&rft.aulast=Tarnawski&rft.aufirst=A&rft.date=1999-09-01&rft.volume=60&rft.issue=5&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=Digestion&rft.issn=00122823&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-11-18 N1 - Date created - 1999-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Human and Escherichia coli beta-glucuronidase hydrolysis of glucuronide conjugates of benzidine and 4-aminobiphenyl, and their hydroxy metabolites. AN - 69992777; 10460807 AB - Individuals exposed to carcinogenic aromatic amines excrete arylamine N- and O-glucuronide metabolites. This study assessed the susceptibility of selected glucuronides to hydrolysis by human and Escherichia coli beta-glucuronidase. N- or O-glucuronides were prepared with the following aglycones: benzidine, N-acetylbenzidine, N'-hydroxy-N-acetylbenzidine, N-hydroxy-N-acetylbenzidine, N-hydroxy-N,N'-diacetylbenzidine, 3-hydroxy-N,N'-diacetylbenzidine, 3-hydroxy-benzidine, 4-aminobiphenyl, N-hydroxy-4-aminobiphenyl, and N-hydroxy-N-acetyl-4-aminobiphenyl. The (3)H- and (14)C-labeled glucuronides were prepared with human or rat liver microsomes using UDP-glucuronic acid as cosubstrate. Each of the 10 glucuronides (6-12 microM) was incubated at pH 5.5 or 7.0 with either human recombinant (pure) or E. coli (commercial preparation) beta-glucuronidase for 30 min at 37 degrees C. Hydrolysis was measured by HPLC. Reaction conditions were optimized, using the O-glucuronide of N-hydroxy-N,N'-diacetylbenzidine. Both enzymes preferentially hydrolyzed O-glucuronides over N-glucuronides and distinguished between structural isomers. With E. coli beta-glucuronidase at pH 7.0, selectivity was demonstrated by the complete hydrolysis of N-hydroxy-N-acetyl-4-aminobiphenyl O-glucuronide in the presence of N-acetylbenzidine N-glucuronide, which was not hydrolyzed. Metabolism by both enzymes was completely inhibited by the specific beta-glucuronidase inhibitor saccharic acid-1,4-lactone (0.5 mM). The concentration of human beta-glucuronidase necessary to achieve significant hydrolysis of glucuronides was substantially more than the amount of enzyme reported previously to be present in urine under either normal or pathological conditions. The bacterial enzyme may hydrolyze O-glucuronides, but not N-glucuronides, in urine at neutral pH. Thus, the nonenzymatic hydrolysis of N-glucuronides by acidic urine is likely a more important source of free amine than enzymatic hydrolysis. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Zenser, T V AU - Lakshmi, V M AU - Davis, B B AD - Veterans Administration Medical Center, St. Louis, Missouri 63125-4199, USA. zensertv@slu.edu Y1 - 1999/09// PY - 1999 DA - September 1999 SP - 1064 EP - 1067 VL - 27 IS - 9 SN - 0090-9556, 0090-9556 KW - Aminobiphenyl Compounds KW - 0 KW - Benzidines KW - Glucuronates KW - Recombinant Proteins KW - 4-biphenylamine KW - 16054949HJ KW - benzidine KW - 2X02101HVF KW - Glucuronidase KW - EC 3.2.1.31 KW - Index Medicus KW - Recombinant Proteins -- metabolism KW - Kinetics KW - Hydrogen-Ion Concentration KW - Humans KW - Glucuronates -- metabolism KW - Hydrolysis KW - Chromatography, High Pressure Liquid KW - Hydroxylation KW - Benzidines -- metabolism KW - Glucuronidase -- metabolism KW - Escherichia coli -- enzymology KW - Aminobiphenyl Compounds -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69992777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=Human+and+Escherichia+coli+beta-glucuronidase+hydrolysis+of+glucuronide+conjugates+of+benzidine+and+4-aminobiphenyl%2C+and+their+hydroxy+metabolites.&rft.au=Zenser%2C+T+V%3BLakshmi%2C+V+M%3BDavis%2C+B+B&rft.aulast=Zenser&rft.aufirst=T&rft.date=1999-09-01&rft.volume=27&rft.issue=9&rft.spage=1064&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-10-07 N1 - Date created - 1999-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone. AN - 69535287; 12884887 AB - Cocaine abuse occurs in 40% to 60% of patients entering opioid maintenance treatment, and effective pharmacotherapies are needed for this combined dependence. This 13-week, randomized, double-blind, placebo-controlled trial evaluated the efficacy of desipramine hydrochloride (0 or 150 mg/d) plus buprenorphine hydrochloride (12 mg/d) or methadone hydrochloride (65 mg/d) in 180 opioid-dependent cocaine abusers (124 men, 56 women). Supervised urine samples were obtained thrice weekly, and self-reported cocaine and heroin use was reported once weekly. Desipramine plasma levels were determined at weeks 4 and 10. In men, opioid abstinence was increased more rapidly over time when treated with methadone than with buprenorphine, whereas cocaine abstinence was increased more with buprenorphine than with methadone. In women, opioid abstinence was increased the least rapidly when treated with buprenorphine plus placebo, while cocaine abstinence was increased more rapidly over time when treated with methadone than with buprenorphine. Regardless of sex or opioid medication, desipramine increased opioid and cocaine abstinence more rapidly over time than placebo. Self-reported opioid use confirmed these findings. Desipramine plasma levels were higher in women than in men, particularly those on buprenorphine maintenance. Higher desipramine plasma levels were associated with greater opioid, but not cocaine, abstinence. Desipramine may be a useful adjunctive medication in facilitating opioid and cocaine abstinence in opioid-maintained patients. The efficacy of opioid medications to treat opioid or cocaine dependence may differ by sex. These findings highlight the importance of including sex as a factor when examining treatment outcome in these types of trials. JF - Archives of general psychiatry AU - Oliveto, A H AU - Feingold, A AU - Schottenfeld, R AU - Jatlow, P AU - Kosten, T R AD - Department of Psychiatry, Yale University School of Medicine, West Haven, Conn, USA. oliveto.alison_h@west-haven.va.gov Y1 - 1999/09// PY - 1999 DA - September 1999 SP - 812 EP - 820 VL - 56 IS - 9 SN - 0003-990X, 0003-990X KW - Analgesics, Opioid KW - 0 KW - Antidepressive Agents, Tricyclic KW - Narcotic Antagonists KW - Buprenorphine KW - 40D3SCR4GZ KW - Desipramine KW - TG537D343B KW - Methadone KW - UC6VBE7V1Z KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Administration Schedule KW - Sex Factors KW - Heroin Dependence -- epidemiology KW - Humans KW - Adult KW - Treatment Outcome KW - Heroin Dependence -- rehabilitation KW - Middle Aged KW - Male KW - Female KW - Comorbidity KW - Opioid-Related Disorders -- epidemiology KW - Methadone -- therapeutic use KW - Buprenorphine -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Desipramine -- therapeutic use KW - Cocaine-Related Disorders -- drug therapy KW - Antidepressive Agents, Tricyclic -- therapeutic use KW - Analgesics, Opioid -- therapeutic use KW - Opioid-Related Disorders -- rehabilitation KW - Cocaine-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69535287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Desipramine+in+opioid-dependent+cocaine+abusers+maintained+on+buprenorphine+vs+methadone.&rft.au=Oliveto%2C+A+H%3BFeingold%2C+A%3BSchottenfeld%2C+R%3BJatlow%2C+P%3BKosten%2C+T+R&rft.aulast=Oliveto&rft.aufirst=A&rft.date=1999-09-01&rft.volume=56&rft.issue=9&rft.spage=812&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-01 N1 - Date created - 2003-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Efficacy of intraduodenal, oral and parenteral boosting in inducing intestinal mucosal immunity to cholera toxin in rats. AN - 69297565; 10574631 AB - Considerable effort has been directed toward developing effective mucosal vaccines, especially those targeted to the intestine, and appropriate delivery systems. Numerous studies have demonstrated that direct immunization of the intestinal mucosa is the most efficient route for generating an intestinal IgA response. The present study examined the effect of three different routes of secondary immunization (boosting), i.e. intraduodenal, oral and parenteral (subcutaneous) on the intensity of the intestinal mucosal immune response in rats subjected to primary intraduodenal immunization with cholera holotoxin. Specific antibody titers and the relative numbers of antibody-secreting cells in the peripheral blood and antibody-containing cells in the intestinal lamina propria concur that vaccination of the intestinal mucosa directly or in combination with an oral boost yields a more vigorous mucosal immune response in comparison to a parenteral boost. JF - Immunological investigations AU - Schmucker, D L AD - San Francisco Department of Veterans Affairs Medical Center and the Department of Anatomy, University of California 94121, USA. SCHMUCKER.DOUGLAS_L@SANFRANCISCO.VA.GOV PY - 1999 SP - 339 EP - 346 VL - 28 IS - 5-6 SN - 0882-0139, 0882-0139 KW - Adjuvants, Immunologic KW - 0 KW - Immunoglobulin A KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Rats KW - Administration, Oral KW - Animals KW - Rats, Inbred F344 KW - Immunization, Secondary -- methods KW - Injections, Subcutaneous KW - Immunoglobulin A -- blood KW - Immunoglobulin A -- biosynthesis KW - Antibody-Producing Cells -- immunology KW - Male KW - Intestinal Mucosa -- cytology KW - Duodenum -- immunology KW - Adjuvants, Immunologic -- administration & dosage KW - Cholera Toxin -- immunology KW - Intestinal Mucosa -- immunology KW - Duodenum -- cytology KW - Cholera Toxin -- administration & dosage KW - Immunity, Mucosal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69297565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunological+investigations&rft.atitle=Efficacy+of+intraduodenal%2C+oral+and+parenteral+boosting+in+inducing+intestinal+mucosal+immunity+to+cholera+toxin+in+rats.&rft.au=Schmucker%2C+D+L&rft.aulast=Schmucker&rft.aufirst=D&rft.date=1999-09-01&rft.volume=28&rft.issue=5-6&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Immunological+investigations&rft.issn=08820139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-12-22 N1 - Date created - 1999-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fertility maintenance and 5-fluorouracil timing within the mammalian fertility cycle. AN - 69273060; 10560591 AB - The mammalian fertility cycle is responsible for tight coordination of molecular, biochemical and cellular events. We have investigated whether timing of 5-fluorouracil (5-FU) chemotherapy within this cycle affects its reproductive toxicology. When this very short half-life, largely S-phase active cytotoxic antimetabolite is administered during the estrous phase (immediate postovulatory) of the fertility cycle, female mice suffer greater subsequent loss of fertility (decreased successful pregnancy rate) than those mice receiving 5-FU during the metestrous, diestrous, or proestrous stages. Pups subsequently born to mothers given 5-FU during the estrous and metestrous stages are of lower weight compared with those born to mothers treated with 5-FU during diestrus or proestrus. Acute lethality is similarly affected by the fertility cycle timing of 5-FU administration. Treatment during estrus is associated with the greatest overall lethal toxicity. This finding indicates that the 5-FU susceptibility of nonreproductive tissues, the integrity of which is essential for survival, may also be coordinated by the mammalian fertility cycle. It is concluded that optimizing the fertility cycle timing of 5-FU (e.g., during the periovulatory, proestrous stage) diminishes the frequency and severity of long-term reproductive damage. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Hrushesky, W J AU - Vyzula, R AU - Wood, P A AD - Department of Medicine, Albany Medical College, Stratton VA Medical Center, NY 12208, USA. Hrushesky.William_M+@albany.va.gov PY - 1999 SP - 413 EP - 420 VL - 13 IS - 5 SN - 0890-6238, 0890-6238 KW - Antimetabolites, Antineoplastic KW - 0 KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Litter Size -- drug effects KW - Animals KW - Litter Size -- physiology KW - Survival Rate KW - Body Weight -- drug effects KW - Body Weight -- physiology KW - Mice KW - Time Factors KW - Male KW - Female KW - Pregnancy KW - Estrus -- physiology KW - Fluorouracil -- toxicity KW - Antimetabolites, Antineoplastic -- toxicity KW - Chronobiology Phenomena KW - Estrus -- drug effects KW - Fertility -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69273060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=Fertility+maintenance+and+5-fluorouracil+timing+within+the+mammalian+fertility+cycle.&rft.au=Hrushesky%2C+W+J%3BVyzula%2C+R%3BWood%2C+P+A&rft.aulast=Hrushesky&rft.aufirst=W&rft.date=1999-09-01&rft.volume=13&rft.issue=5&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=08906238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-11-24 N1 - Date created - 1999-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - General and AIDS-Specific Stress, Coping, and Psychological Distress in the Biracial Coping and Change Study Cohort of Gay Men AN - 61665092; 200003194 AB - Responses of 297 white & African American gay men with & without HIV/AIDS (human immunodeficiency virus/acquired immune deficiency syndrome) participating in the Chicago (IL) Multicenter AIDS Cohort Study & Coping & Change Study, 1992-1994, revealed that the degree of detachment- vs involvement-oriented coping strategies used to deal with stressors was unrelated to the level of reported depressed mood & AIDS-specific distress, except among the most severely depressed men (upper 15%), for whom greater reliance on involvement coping strategies was associated with decreased depression. Implications & suggestions for future research are discussed. 1 Table, 2 Figures, 30 References. Adapted from the source document. JF - AIDS and Behavior AU - DeMarco, Frank J AU - Ostrow, David G AU - DiFranceisco, Wayne AD - Veterans Affairs Puget Sound Health Care System, Seattle, WA demarco.frank_j@seattle.va.gov Y1 - 1999/09// PY - 1999 DA - September 1999 SP - 177 EP - 186 VL - 3 IS - 3 SN - 1090-7165, 1090-7165 KW - Whites KW - Psychological Stress KW - Chicago, Illinois KW - Black Americans KW - Depression (Psychology) KW - Males KW - Biraciality KW - Acquired Immune Deficiency Syndrome KW - Psychological Distress KW - Homosexuality KW - Coping KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61665092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=General+and+AIDS-Specific+Stress%2C+Coping%2C+and+Psychological+Distress+in+the+Biracial+Coping+and+Change+Study+Cohort+of+Gay+Men&rft.au=DeMarco%2C+Frank+J%3BOstrow%2C+David+G%3BDiFranceisco%2C+Wayne&rft.aulast=DeMarco&rft.aufirst=Frank&rft.date=1999-09-01&rft.volume=3&rft.issue=3&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Psychological Stress; Coping; Psychological Distress; Biraciality; Homosexuality; Males; Depression (Psychology); Whites; Black Americans; Chicago, Illinois ER - TY - JOUR T1 - Hepatitis C virus: current understanding and prospects for future therapies AN - 17330570; 4609468 AB - Hepatitis C virus (HCV) is the leading cause of chronic liver disease worldwide and the leading indication for liver transplantation. The hallmark of the disease is its propensity to evolve into chronicity, probably because viral heterogeneity allows the virus to escape immune-mediated neutralization. Treatment with interferon alpha (IFN- alpha ) has been disappointing, but higher and more frequent doses, and combination therapies, including nucleoside analogs, might lead to improved suppression of HCV RNA levels. Molecular analysis of HCV before and during treatment has indicated that high viral RNA levels and the presence of HCV genotype 1 are independent predictors of poor treatment outcome. New antiviral agents in development include inhibitors of HCV replicative enzymes, such as protease, helicase and polymerase, as well as several genetic approaches, such as ribozymes and antisense oligonucleotides. The main hindrance to drug development for hepatitis C is the lack of a small animal model or a productive tissue culture system for assessing drug action. JF - Molecular Medicine Today AU - Rosen, H R AU - Gretch AD - Division of Gastroenterology and Hepatology, Portland VA Medical Center, Portland, OR 97207, USA, hugo.rosen@med.va.gov Y1 - 1999/09// PY - 1999 DA - Sep 1999 SP - 393 EP - 399 VL - 5 IS - 9 SN - 1357-4310, 1357-4310 KW - Hepatitis C virus KW - alpha -Interferon KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Tissue culture KW - Antisense KW - Antiviral agents KW - Reviews KW - Ribozymes KW - W 30965:Miscellaneous, Reviews KW - V 22125:Therapy KW - W3 33000:General topics and reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17330570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Medicine+Today&rft.atitle=Hepatitis+C+virus%3A+current+understanding+and+prospects+for+future+therapies&rft.au=Rosen%2C+H+R%3BGretch&rft.aulast=Rosen&rft.aufirst=H&rft.date=1999-09-01&rft.volume=5&rft.issue=9&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Molecular+Medicine+Today&rft.issn=13574310&rft_id=info:doi/10.1016%2FS1357-4310%2899%2901523-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hepatitis C virus; Ribozymes; Reviews; Tissue culture; Antiviral agents; Antisense DO - http://dx.doi.org/10.1016/S1357-4310(99)01523-3 ER - TY - JOUR T1 - Membrane insertion scanning of the human ileal sodium/bile acid co-transporter. AN - 70011720; 10471288 AB - Mammalian sodium-dependent bile acid transporters (SBATs) responsible for bile salt uptake across the liver sinusoidal or ileal/renal brush border membrane have been identified and share approximately 35% amino acid sequence identity. Programs for prediction of topology and localization of transmembrane helices identify eight or nine hydrophobic regions for the SBAT sequences as membrane spanning. Analysis of N-linked glycosylation has provided evidence for an exoplasmic N-terminus and a cytoplasmic C-terminus, indicative of an odd number of transmembrane segments. To determine the membrane topography of the human ileal SBAT (HISBAT), an in vitro translation/translocation protocol was employed using three different fusion protein constructs. Individual HISBAT segments were analyzed for signal anchor or stop translocation (stop transfer) activity by insertion between a cytoplasmic anchor (HK M0) or a signal anchor segment (HK M1) and a glycosylation flag (HK beta). To examine consecutive HISBAT sequences, sequential hydrophobic sequences were inserted into the HK M0 vector or fusion vectors were made that included the glycosylated N-terminus of HISBAT, sequential hydrophobic sequences, and the glycosylation flag. Individual signal anchor (SA) and stop transfer (ST) properties were found for seven out of the nine predicted hydrophobic segments (H1, H2, H4, H5, H6, H7, and H9), supporting a seven transmembrane segment model. However, the H3 region was membrane inserted when translated in the context of the native HISBAT flanking sequences. Furthermore, results from translations of sequential constructs ending after H7 provided support for integration of H8. These data provide support for a SBAT transmembrane domain model with nine integrated segments with an exoplasmic N-terminus and a cytoplasmic C-terminus consistent with a recent predictive analysis of this transporter topology. JF - Biochemistry AU - Hallén, S AU - Brändén, M AU - Dawson, P A AU - Sachs, G AD - UCLA and Wadsworth Veterans Administration Hospital, Los Angeles, California 90073, USA. Y1 - 1999/08/31/ PY - 1999 DA - 1999 Aug 31 SP - 11379 EP - 11388 VL - 38 IS - 35 SN - 0006-2960, 0006-2960 KW - Bile Acids and Salts KW - 0 KW - Carrier Proteins KW - Membrane Glycoproteins KW - Organic Anion Transporters, Sodium-Dependent KW - Peptide Fragments KW - Protein Sorting Signals KW - Symporters KW - sodium-bile acid cotransporter KW - 145420-23-1 KW - Sodium KW - 9NEZ333N27 KW - Index Medicus KW - Animals KW - Protein Structure, Secondary KW - Protein Sorting Signals -- metabolism KW - Genetic Vectors -- chemical synthesis KW - Peptide Fragments -- genetics KW - Humans KW - Biological Transport -- genetics KW - Intracellular Membranes -- chemistry KW - Protein Sorting Signals -- chemistry KW - Ileum -- metabolism KW - Amino Acid Sequence KW - Genetic Vectors -- metabolism KW - Ileum -- chemistry KW - Peptide Fragments -- chemical synthesis KW - Dogs KW - Molecular Sequence Data KW - Intracellular Membranes -- metabolism KW - Mutagenesis, Insertional KW - Membrane Glycoproteins -- chemistry KW - Carrier Proteins -- metabolism KW - Carrier Proteins -- chemistry KW - Carrier Proteins -- genetics KW - Bile Acids and Salts -- metabolism KW - Sodium -- metabolism KW - Membrane Glycoproteins -- metabolism KW - Membrane Glycoproteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70011720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Membrane+insertion+scanning+of+the+human+ileal+sodium%2Fbile+acid+co-transporter.&rft.au=Hall%C3%A9n%2C+S%3BBr%C3%A4nd%C3%A9n%2C+M%3BDawson%2C+P+A%3BSachs%2C+G&rft.aulast=Hall%C3%A9n&rft.aufirst=S&rft.date=1999-08-31&rft.volume=38&rft.issue=35&rft.spage=11379&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-09-28 N1 - Date created - 1999-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Helicobacter pylori Vacuolating Cytotoxin (VacA) Disorganizes the Cytoskeletal Architecture of Gastric Epithelial Cells AN - 17363570; 4577686 AB - Helicobacter pylori colonization of the gastric mucosa induces peptic ulcer disease and interferes with ulcer healing. Re-epithelialization is an essential component of ulcer healing. It requires cell migration and proliferation which are dependent on the cell cytoskeleton. Most H. pylori strains produce a toxin (VacA) that induces multiple structural and functional changes in epithelial cells. In this study, we investigated the effects of VacA on the gastric epithelial cell cytoskeletal architecture. Exposure of rat gastric epithelial cells to purified VacA from H. pylori 60190 significantly inhibited actin stress fiber formation (83 plus or minus 5% reduction; p < 0.0001) and disorganized microtubule pattern (90 plus or minus 8%; p < 0.001). Furthermore, VacA treatment significantly reduced tyrosine phosphorylation of focal adhesion kinase (FAK) (by 45 plus or minus 6%; p < 0.002) and its expression in focal adhesions (73 plus or minus 8%; p < 0.0001). These findings suggest that H. pylori VacA interferes with cytoskeleton-dependent cell functions and with the transmission of signals related to cell spreading and growth. JF - Biochemical and Biophysical Research Communications AU - Pai, R AU - Cover, T L AU - Tarnawski, A S AD - Department of Veterans Affairs Medical Center, Medical Service, Long Beach, 90822, California, atarnawski@pop.long-beach.va.gov Y1 - 1999/08/19/ PY - 1999 DA - 1999 Aug 19 SP - 245 EP - 250 PB - Academic Press VL - 262 IS - 1 SN - 0006-291X, 0006-291X KW - VacA protein KW - Microbiology Abstracts B: Bacteriology KW - Cytoskeleton KW - Epithelial cells KW - Helicobacter pylori KW - Ulcers KW - Cytotoxins KW - Gastrointestinal tract diseases KW - Toxins KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17363570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Helicobacter+pylori+Vacuolating+Cytotoxin+%28VacA%29+Disorganizes+the+Cytoskeletal+Architecture+of+Gastric+Epithelial+Cells&rft.au=Pai%2C+R%3BCover%2C+T+L%3BTarnawski%2C+A+S&rft.aulast=Pai&rft.aufirst=R&rft.date=1999-08-19&rft.volume=262&rft.issue=1&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1006%2Fbbrc.1999.1194 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Helicobacter pylori; Ulcers; Gastrointestinal tract diseases; Cytoskeleton; Epithelial cells; Toxins; Cytotoxins DO - http://dx.doi.org/10.1006/bbrc.1999.1194 ER - TY - JOUR T1 - Expression of eIF4E during head and neck tumorigenesis: possible role in angiogenesis. AN - 85305218; pmid-10443829 AB - OBJECTIVE: The translation initiation factor eIF4E (4E) when overexpressed in mammalian cells results in their oncogenic transformation. 4E facilitates the synthesis of two powerful tumor angiogenic factors (VEGF and FGF-2) by selectively enhancing their translation. 4E is overexpressed not only in all head and neck squamous cell cancers but also in some dysplastic margins. Tumorigenesis in the head and neck is proposed to be a multistep process preceded by clinically evident precancerous lesions. Molecular events underlie the histological changes that herald transformation. We wanted to study the role of 4E in tumorigenesis and further elucidate its causal role in angiogenesis. METHODS: An immunohistochemical analysis with antibodies to 4E, VEGF, and basic (b)-FGF was performed on 115 specimens of the head and neck representing various stages of histological progression of malignancy. This was correlated with mean vessel density (MVD) using factor VIII. RESULTS: There were 41 cases of hyperplasia and low-grade dysplasia, 40 cases of high-grade dysplasia and 34 cases of cancer. There was a significant increase in the percent of cases expressing 4E from low-grade dysplasia through tumor. However, for VEGF and b-FGF the significant increase was only seen between the tumor group and dysplastic groups and no significant increase was noted between low-grade and high-grade dysplasia There was a significant increase in MVD from low- (10.7+/-1) to high-grade grade dysplasia (18.0+/-2.3). This increase was even more striking for the 4E positive cases. CONCLUSION: 4E elevation is correlated with progressive cell transformation in the head and neck. Its correlation with VEGF, b-FGF, and MVD potentiates its possible role in angiogenesis. JF - The Laryngoscope AU - Nathan, C O AU - Franklin, S AU - Abreo, F W AU - Nassar, R AU - de Benedetti, A AU - Williams, J AU - Stucker, F J AD - Department of Otolaryngology/Head & Neck Surgery, Louisiana State University Medical Center and Veterans Administration, Shreveport 71130, USA. cnatha@lsumc.edu Y1 - 1999/08// PY - 1999 DA - August 1999 SP - 1253 EP - 1258 VL - 109 IS - 8 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Vascular Endothelial Growth Factor A KW - Eukaryotic Initiation Factor-4E KW - Neoplasm Staging KW - Precancerous Conditions KW - Antibodies, Neoplasm -- genetics KW - Vascular Endothelial Growth Factors KW - Humans KW - Cell Line, Transformed KW - Immunohistochemistry KW - Peptide Initiation Factors -- genetics KW - Gene Expression -- genetics KW - Fibroblast Growth Factor 2 -- genetics KW - Lymphokines -- genetics KW - Endothelial Growth Factors -- genetics KW - Head and Neck Neoplasms -- pathology KW - Neoplasms, Squamous Cell -- genetics KW - Head and Neck Neoplasms -- genetics KW - Protein Isoforms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85305218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Expression+of+eIF4E+during+head+and+neck+tumorigenesis%3A+possible+role+in+angiogenesis.&rft.au=Nathan%2C+C+O%3BFranklin%2C+S%3BAbreo%2C+F+W%3BNassar%2C+R%3Bde+Benedetti%2C+A%3BWilliams%2C+J%3BStucker%2C+F+J&rft.aulast=Nathan&rft.aufirst=C&rft.date=1999-08-01&rft.volume=109&rft.issue=8&rft.spage=1253&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-01-15 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - CSF monoamine metabolite and beta endorphin levels in recently detoxified alcoholics and healthy controls: prediction of alcohol cue-induced craving? AN - 70004961; 10470976 AB - Abnormalities in central neurotransmitter systems have been described in alcohol-dependent individuals and may contribute to alcohol craving. This study compared cerebrospinal fluid (CSF) levels of monoamine metabolites and beta endorphin levels in samples from early-onset alcohol-dependent patients (n = 20), late-onset alcohol-dependent patients (n = 14), and healthy controls (n = 23). It also evaluated whether these CSF measures levels predicted the degree of craving experienced in response to an alcohol cue. Individuals meeting DSM-III and -IV R-criteria for alcohol dependence, 1 to 3 months postdetoxification, and healthy controls underwent a lumbar puncture. Patients also completed a cue exposure test day between 3 and 15 days later. Alcohol-dependent patients had lower CSF levels of the norepinephrine metabolite MHPG compared with the healthy subjects, but this difference disappeared when differences in age between the groups were accounted for. No other group comparisons between patients and healthy subjects reached significance. CSF levels of the dopamine metabolite HVA were significantly higher in the early-onset patients compared with the late-onset patients and controls. The CSF measures did not predict the precue levels of craving, or the increase in craving after alcohol cue exposure. These results are inconclusive about the role of monoaminergic dysregulation in recovering alcoholics. They also question the utility of these CSF measures to predict alcohol cue reactivity in patients who have been sober at least 1 month. JF - Alcoholism, clinical and experimental research AU - Petrakis, I L AU - Trevisan, L AU - D'Souza, C AU - Gil, R AU - Krasnicki, S AU - Webb, E AU - Heninger, G AU - Cooney, N AU - Krystal, J H AD - Department of Psychiatry, Yale University, New Haven, Connecticut, USA. petrakis.ismene_l+@west-haven.va.gov Y1 - 1999/08// PY - 1999 DA - August 1999 SP - 1336 EP - 1341 VL - 23 IS - 8 SN - 0145-6008, 0145-6008 KW - Biogenic Monoamines KW - 0 KW - Biomarkers KW - Ethanol KW - 3K9958V90M KW - Methoxyhydroxyphenylglycol KW - 534-82-7 KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Methoxyhydroxyphenylglycol -- metabolism KW - Biomarkers -- cerebrospinal fluid KW - Homovanillic Acid -- cerebrospinal fluid KW - Methoxyhydroxyphenylglycol -- cerebrospinal fluid KW - Hydroxyindoleacetic Acid -- metabolism KW - Humans KW - Adult KW - Case-Control Studies KW - Hydroxyindoleacetic Acid -- cerebrospinal fluid KW - Middle Aged KW - Homovanillic Acid -- metabolism KW - Male KW - Female KW - Biogenic Monoamines -- cerebrospinal fluid KW - Behavior, Addictive -- cerebrospinal fluid KW - Substance Withdrawal Syndrome -- metabolism KW - Alcoholism -- cerebrospinal fluid KW - Behavior, Addictive -- metabolism KW - Alcoholism -- metabolism KW - Ethanol -- metabolism KW - Substance Withdrawal Syndrome -- cerebrospinal fluid KW - Biogenic Monoamines -- metabolism KW - Ethanol -- cerebrospinal fluid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70004961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=CSF+monoamine+metabolite+and+beta+endorphin+levels+in+recently+detoxified+alcoholics+and+healthy+controls%3A+prediction+of+alcohol+cue-induced+craving%3F&rft.au=Petrakis%2C+I+L%3BTrevisan%2C+L%3BD%27Souza%2C+C%3BGil%2C+R%3BKrasnicki%2C+S%3BWebb%2C+E%3BHeninger%2C+G%3BCooney%2C+N%3BKrystal%2C+J+H&rft.aulast=Petrakis&rft.aufirst=I&rft.date=1999-08-01&rft.volume=23&rft.issue=8&rft.spage=1336&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-10-26 N1 - Date created - 1999-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The pathogenesis of chronic obstructive pulmonary disease. AN - 69973911; 10452563 AB - Cigarette smoking is the main risk factor for the development of chronic obstructive pulmonary disease (COPD). An accelerated rate of lung function decline that causes clinically significant COPD, however, is present in only a minority of smokers. In addition to the cumulative amount of cigarettes smoked, other environmental and genetic properties contribute to this variable physiological response. This article reviews the role of airway hyperresponsiveness, mucus hypersecretion, infection, and proteases in the development of COPD. JF - The American journal of the medical sciences AU - Markewitz, B A AU - Owens, M W AU - Payne, D K AD - Section of Pulmonary and Critical Care Medicine, Department of Medicine, Overton Brooks Veterans Administration Medical Center, Shreveport, Louisiana 71101-4295, USA. Y1 - 1999/08// PY - 1999 DA - August 1999 SP - 74 EP - 78 VL - 318 IS - 2 SN - 0002-9629, 0002-9629 KW - Dust KW - 0 KW - Oxidants KW - Protease Inhibitors KW - Tobacco Smoke Pollution KW - Endopeptidases KW - EC 3.4.- KW - Abridged Index Medicus KW - Index Medicus KW - Bronchial Hyperreactivity -- etiology KW - Humans KW - Smoking -- adverse effects KW - Bronchial Hyperreactivity -- complications KW - Protease Inhibitors -- metabolism KW - Risk Factors KW - Endopeptidases -- metabolism KW - Tobacco Smoke Pollution -- adverse effects KW - Bronchi -- secretion KW - Occupational Exposure -- adverse effects KW - Oxidants -- metabolism KW - Dust -- adverse effects KW - Mucus -- secretion KW - Respiratory Tract Infections -- complications KW - Lung Diseases, Obstructive -- etiology KW - Lung Diseases, Obstructive -- metabolism KW - Lung Diseases, Obstructive -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69973911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=The+pathogenesis+of+chronic+obstructive+pulmonary+disease.&rft.au=Markewitz%2C+B+A%3BOwens%2C+M+W%3BPayne%2C+D+K&rft.aulast=Markewitz&rft.aufirst=B&rft.date=1999-08-01&rft.volume=318&rft.issue=2&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-09-08 N1 - Date created - 1999-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Detection of Illicit Opioid and Cocaine Use in Methadone Maintenance Treatment AN - 61645108; 200001499 AB - Reports a study that compared results of frequent (twice weekly) vs less frequent urine testing for drug use among a total of 166 patients at four methadone maintenance treatment (MMT) programs in the San Francisco (CA) Bay Area. During the same period, the four MMT programs tested the patients according to their standard protocols. The more frequent research tests identified approximately 50% more illicit opioid users & 70% more cocaine users than did the less frequent program tests. Patients who were drug positive according to the research tests but drug negative according to the program tests tended to be infrequent users. Results suggest that more frequent urine testing, even for time-limited periods, would produce more accurate depictions of drug use prevalence & help indicate the direction of interventions. 3 Tables, 7 References. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Wasserman, David A AU - Korcha, Rachael AU - Havassy, Barbara E AU - Hall, Sharon M AD - Mental Health Service, San Francisco Veterans Affairs Medical Center, CA wasserman.david_a@sanfrancisco.va.gov Y1 - 1999/08// PY - 1999 DA - August 1999 SP - 561 EP - 571 VL - 25 IS - 3 SN - 0095-2990, 0095-2990 KW - Narcotic Drugs KW - Drug Use Screening KW - Cocaine KW - San Francisco, California KW - Treatment Methods KW - Drug Abuse KW - Methadone Maintenance KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61645108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Detection+of+Illicit+Opioid+and+Cocaine+Use+in+Methadone+Maintenance+Treatment&rft.au=Wasserman%2C+David+A%3BKorcha%2C+Rachael%3BHavassy%2C+Barbara+E%3BHall%2C+Sharon+M&rft.aulast=Wasserman&rft.aufirst=David&rft.date=1999-08-01&rft.volume=25&rft.issue=3&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Methadone Maintenance; Drug Abuse; Drug Use Screening; Cocaine; Treatment Methods; Narcotic Drugs; San Francisco, California ER - TY - JOUR T1 - Identification of a Novel Penicillin-Binding Protein from Helicobacter pylori AN - 17329447; 4576396 AB - The Helicobacter pylori genome encodes four penicillin-binding proteins (PBPs). PBPs 1, 2, and 3 exhibit similarities to known PBPs. The sequence of PBP 4 is unique in that it displays a novel combination of two highly conserved PBP motifs and an absence of a third motif. Expression of PBP 4, but not PBP 1, 2, or 3, is significantly increased during mid- to late-log-phase growth. JF - Journal of Bacteriology AU - Krishnamurthy, P AU - Parlow, M H AU - Schneider, J AU - Burroughs, S AU - Wickland, C AU - Vakil, N B AU - Dunn, B E AU - Phadnis, SH AD - Clement J. Zablocki VA Medical Center, Pathology and Laboratory Medicine Service (DS-113), 5000 West National Ave., Milwaukee, WI 53295-1000, Bruce.Dunn@med.va.gov Y1 - 1999/08// PY - 1999 DA - Aug 1999 SP - 5107 EP - 5110 VL - 181 IS - 16 SN - 0021-9193, 0021-9193 KW - genomes KW - penicillin-binding protein KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Helicobacter pylori KW - G 07320:Bacterial genetics KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17329447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Identification+of+a+Novel+Penicillin-Binding+Protein+from+Helicobacter+pylori&rft.au=Krishnamurthy%2C+P%3BParlow%2C+M+H%3BSchneider%2C+J%3BBurroughs%2C+S%3BWickland%2C+C%3BVakil%2C+N+B%3BDunn%2C+B+E%3BPhadnis%2C+SH&rft.aulast=Krishnamurthy&rft.aufirst=P&rft.date=1999-08-01&rft.volume=181&rft.issue=16&rft.spage=5107&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Helicobacter pylori; penicillin-binding protein ER - TY - JOUR T1 - Coupling efficiency of brain beta-adrenergic receptors to Gs protein in suicide, alcoholism and control subjects. AN - 69960537; 10445370 AB - Abnormal beta-adrenergic receptor (betaAR) density in the brains of suicide victims has been reported, although results of studies are inconsistent. Ethanol modifies betaAR-mediated signal transduction. Moreover abnormal betaAR function has been implicated in alcoholism. BetaAR antagonists, which were used as ligands in previous betaAR binding studies, also bind to 5-HT1B/1Dbeta receptors; hence, their estimates of betaAR density are confounded by binding to 5-HT1B/1Dbeta receptors. More importantly, previous studies did not examine betaAR agonist affinity or coupling efficiency to Gs protein. We investigated agonist affinity and coupling efficiency of betaAR to Gs protein in the brains of ten suicide victims, six subjects with alcoholism, and eight controls. There were no differences in betaAR density in either the frontal cortex or hippocampus of suicide victims or alcoholic subjects compared to controls. Preliminary results indicate betaAR supercoupling in suicide victims in both brain regions and uncoupling in alcoholic subjects in the frontal cortex. These results are discussed in view of the existing literature on the role of betaAR in suicide and alcoholism and the mechanism of action of antidepressants. JF - Psychopharmacology AU - Gurguis, G N AU - Turkka, J AU - Laruelle, M AU - Kleinman, J AU - Linnoila, M AD - Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892-1256, USA. gurguis.george@dallas.va.gov Y1 - 1999/07// PY - 1999 DA - July 1999 SP - 31 EP - 38 VL - 145 IS - 1 SN - 0033-3158, 0033-3158 KW - Adrenergic beta-Antagonists KW - 0 KW - Receptors, Adrenergic, beta KW - Iodocyanopindolol KW - 83498-72-0 KW - GTP-Binding Protein alpha Subunits, Gs KW - EC 3.6.5.1 KW - Index Medicus KW - Adrenergic beta-Antagonists -- analysis KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Iodocyanopindolol -- analysis KW - Male KW - Female KW - Receptors, Adrenergic, beta -- metabolism KW - Receptors, Adrenergic, beta -- analysis KW - Cerebral Cortex -- chemistry KW - Cerebral Cortex -- metabolism KW - Hippocampus -- metabolism KW - Suicide KW - Alcoholism -- metabolism KW - GTP-Binding Protein alpha Subunits, Gs -- analysis KW - GTP-Binding Protein alpha Subunits, Gs -- metabolism KW - Hippocampus -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69960537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Coupling+efficiency+of+brain+beta-adrenergic+receptors+to+Gs+protein+in+suicide%2C+alcoholism+and+control+subjects.&rft.au=Gurguis%2C+G+N%3BTurkka%2C+J%3BLaruelle%2C+M%3BKleinman%2C+J%3BLinnoila%2C+M&rft.aulast=Gurguis&rft.aufirst=G&rft.date=1999-07-01&rft.volume=145&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-09-14 N1 - Date created - 1999-09-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Combinations of vancomycin and beta-lactams are synergistic against staphylococci with reduced susceptibilities to vancomycin. AN - 69866568; 10390234 AB - Evidence of synergism between combinations of vancomycin and beta-lactam antibiotics against 59 isolates of methicillin-resistant staphylococci (Staphylococcus aureus, Staphylococcus epidermidis, and Staphylococcus haemolyticus) for which vancomycin MICs ranged from 1 to 16 microg/ml were tested by broth microdilution checkerboard, disk diffusion, agar dilution, and time-kill antimicrobial susceptibility tests. The combination of vancomycin and oxacillin demonstrated synergy by all test methods against 30 of 59 isolates; no antagonism was seen. Synergy with vancomycin was also found by modified disk diffusion testing for ceftriaxone, ceftazidime, cefpodoxime, and amoxicillin-clavulanate but not for aztreonam. Evidence of synergy correlated directly with vancomycin MICs. The efficacy of vancomycin given alone and in combination with nafcillin was tested in the rabbit model of experimental endocarditis caused by three clinical isolates of glycopeptide-intermediate-susceptible S. aureus (GISA) (isolates HIP5827, HIP5836, and MU50). Two of the GISA isolates (isolates MU50 and HIP5836) were extremely virulent in this model, with 27 of 42 (64%) animals dying during the 3-day trial. Therapy with either vancomycin or nafcillin given as a single agent was ineffective for animals infected with HIP5827 or MU50. However, the combination of vancomycin and nafcillin resulted in a mean reduction of 4.52 log10 CFU/g of aortic valvular vegetations per g compared to the reduction for controls for animals infected with HIP5827 and a reduction of 4. 15 log10 CFU/g for animals infected with MU50. Renal abscesses caused by HIP5827 were sterilized significantly better with the combination of vancomycin and nafcillin than by either treatment alone. We conclude that the combination of vancomycin and beta-lactams with antistaphylococcal activity is an effective regimen for the treatment of infections with clinical strains of staphylococci which demonstrate reduced susceptibility to glycopeptides. JF - Antimicrobial agents and chemotherapy AU - Climo, M W AU - Patron, R L AU - Archer, G L AD - Department of Medicine, Medical College of Virginia Campus of Virginia Commonwealth University, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, USA. Climo.Michael@Richmond.va.gov Y1 - 1999/07// PY - 1999 DA - July 1999 SP - 1747 EP - 1753 VL - 43 IS - 7 SN - 0066-4804, 0066-4804 KW - Anti-Bacterial Agents KW - 0 KW - beta-Lactams KW - Vancomycin KW - 6Q205EH1VU KW - Index Medicus KW - Animals KW - Staphylococcal Infections -- drug therapy KW - Drug Resistance, Microbial KW - Rabbits KW - Methicillin Resistance KW - Drug Synergism KW - Microbial Sensitivity Tests KW - Vancomycin -- pharmacology KW - Endocarditis, Bacterial -- drug therapy KW - Drug Therapy, Combination -- pharmacology KW - Anti-Bacterial Agents -- pharmacology KW - Staphylococcus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69866568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Combinations+of+vancomycin+and+beta-lactams+are+synergistic+against+staphylococci+with+reduced+susceptibilities+to+vancomycin.&rft.au=Climo%2C+M+W%3BPatron%2C+R+L%3BArcher%2C+G+L&rft.aulast=Climo&rft.aufirst=M&rft.date=1999-07-01&rft.volume=43&rft.issue=7&rft.spage=1747&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-08-05 N1 - Date created - 1999-08-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antimicrob Agents Chemother. 1993 Nov;37(11):2432-7 [8285629] Yale J Biol Med. 1971 Oct;44(2):206-13 [5123055] J Infect Dis. 1995 Jun;171(6):1646-50 [7769310] J Bacteriol. 1996 Aug;178(15):4696-703 [8755902] J Bacteriol. 1997 Apr;179(8):2557-66 [9098053] J Antimicrob Chemother. 1997 Jul;40(1):59-66 [9249205] J Antimicrob Chemother. 1997 Jul;40(1):135-6 [9249217] Antimicrob Agents Chemother. 1997 Aug;41(8):1788-93 [9257762] MMWR Morb Mortal Wkly Rep. 1997 Sep 5;46(35):813-5 [9310213] Antimicrob Agents Chemother. 1998 Jan;42(1):100-7 [9449268] J Antimicrob Chemother. 1997 May;39 Suppl A:47-51 [9511062] J Clin Microbiol. 1998 Apr;36(4):1020-7 [9542929] Antimicrob Agents Chemother. 1998 Jun;42(6):1355-60 [9624475] JAMA. 1976 Oct 4;236(14):1604-6 [989135] J Infect Dis. 1984 Jun;149(6):894-903 [6564133] Infection. 1985;13 Suppl 1:S123-8 [3850854] J Infect Dis. 1990 Jan;161(1):45-51 [2295858] Antimicrob Agents Chemother. 1990 Jun;34(6):1227-31 [2393284] Eur J Clin Microbiol Infect Dis. 1990 Nov;9(11):804-9 [2150814] Ann Intern Med. 1991 Nov 1;115(9):674-80 [1929035] Infection. 1991;19 Suppl 5:S276-8 [1783443] J Biol Chem. 1992 Jun 5;267(16):11248-54 [1597460] J Infect Dis. 1992 Nov;166(5):1066-72 [1402017] Antimicrob Agents Chemother. 1993 Feb;37(2):342-6 [8452368] Lancet. 1998 Apr 18;351(9110):1212 [9643727] Eur J Clin Microbiol Infect Dis. 1998 Mar;17(3):143-50 [9665294] Antimicrob Agents Chemother. 1998 Oct;42(10):2739-44 [9756787] Microb Drug Resist. 1998 Fall;4(3):159-68 [9818967] Antimicrob Agents Chemother. 1994 Oct;38(10):2231-7 [7840550] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway. AN - 69857568; 10384120 AB - To determine whether the systemic immune activation by CpG DNA could alter airway inflammation, we pretreated mice with either i.v. bacterial DNA (bDNA) or oligonucleotides with or without CpG motifs, exposed these mice to LPS by inhalation, and measured the inflammatory response systemically and in the lung immediately following LPS inhalation. Compared with non-CpG oligonucleotides, i. v. treatment with CpG oligonucleotides resulted in higher systemic concentrations of polymorphonuclear leukocytes, IL-10, and IL-12, but significantly reduced the concentration of total cells, polymorphonuclear leukocytes, TNF-alpha, and macrophage inflammatory protein-2 in the lavage fluid following LPS inhalation. The immunoprotective effect of CpG-containing oligonucleotides was dose-dependent and was most pronounced in mice pretreated between 2 and 4 h before the inhalation challenge, corresponding to the peak levels of serum cytokines. bDNA resulted in a similar immunoprotective effect, and methylation of the CpG motifs abolished the protective effect of CpG oligonucleotides. The protective effect of CpG oligonucleotides was observed in mice with either a disrupted IL-10 or IFN-gamma gene, but release of cytokines in the lung was increased, especially in the mice lacking IFN-gamma. In contrast, CpG DNA did not protect mice with a disrupted IL-12 gene against the LPS-induced cellular influx, even though CpG DNA reduced the release of TNF-alpha and macrophage inflammatory protein-2 in the lung. These findings indicate that CpG-containing oligonucleotides or bDNA are protected against LPS-induced cellular airway inflammation through an IL-12-dependent pathway, and that the pulmonary cytokine and cellular changes appear to be regulated independently. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Schwartz, D A AU - Wohlford-Lenane, C L AU - Quinn, T J AU - Krieg, A M AD - Veterans Administration Medical Center, Iowa City 52242, USA. david_schwartz@uiowa.edu Y1 - 1999/07/01/ PY - 1999 DA - 1999 Jul 01 SP - 224 EP - 231 VL - 163 IS - 1 SN - 0022-1767, 0022-1767 KW - DNA, Bacterial KW - 0 KW - Lipopolysaccharides KW - Oligonucleotides KW - Interleukin-10 KW - 130068-27-8 KW - Interleukin-12 KW - 187348-17-0 KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Interferon-gamma -- genetics KW - Injections, Intravenous KW - Mice KW - Mice, Knockout KW - Interleukin-10 -- deficiency KW - Inflammation -- prevention & control KW - Interferon-gamma -- deficiency KW - Mice, Inbred C57BL KW - Inflammation -- immunology KW - Interleukin-10 -- genetics KW - Administration, Inhalation KW - Male KW - Lung -- immunology KW - DNA, Bacterial -- pharmacology KW - DNA Methylation KW - Oligonucleotides -- pharmacology KW - Interleukin-12 -- physiology KW - CpG Islands -- immunology KW - Lipopolysaccharides -- toxicity KW - Lung -- pathology KW - Oligonucleotides -- chemical synthesis KW - Oligonucleotides -- administration & dosage KW - Interleukin-12 -- blood KW - DNA, Bacterial -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69857568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Bacterial+DNA+or+oligonucleotides+containing+unmethylated+CpG+motifs+can+minimize+lipopolysaccharide-induced+inflammation+in+the+lower+respiratory+tract+through+an+IL-12-dependent+pathway.&rft.au=Schwartz%2C+D+A%3BWohlford-Lenane%2C+C+L%3BQuinn%2C+T+J%3BKrieg%2C+A+M&rft.aulast=Schwartz&rft.aufirst=D&rft.date=1999-07-01&rft.volume=163&rft.issue=1&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-07-15 N1 - Date created - 1999-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vitro activities of the everninomicin SCH 27899 and other newer antimicrobial agents against Borrelia burgdorferi AN - 17372938; 4585328 AB - The in vitro activity of the everninomicin antibiotic SCH 27899 against 17 isolates of Borrelia spp. was investigated. MICs ranged from 0.06 to 0.5 mu g/ml. Time-kill studies with the B31 strain of B. burgdorferi demonstrated greater than or equal to 3-log sub(10)-unit killing after 72 h with concentrations representing four times the MIC. The in vitro activity of four other newer antimicrobial agents, meropenem, cefepime, quinupristin-dalfopristin, and linezolid, was also tested against the B31 strain. Meropenem was the most potent of the latter agents, with an MIC of 0.125 mu g/ml. JF - Antimicrobial Agents & Chemotherapy AU - Dever, L L AU - Torigian, C V AU - Barbour, A G AD - Medical Service (111-ID), VA Medical Center, 385 Tremont Ave., East Orange, NJ 07018, USA, dever.lisa@east-orange.va.gov Y1 - 1999/07// PY - 1999 DA - Jul 1999 SP - 1773 EP - 1775 VL - 43 IS - 7 SN - 0066-4804, 0066-4804 KW - SCH 27899 KW - Borrelia burgdorferi KW - Linezolid KW - Oxazolidinone KW - Oxazolidinones KW - Streptogramin KW - cefepime KW - dalfopristin KW - everninomicin KW - meropenem KW - quinupristin KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Medical and Pharmaceutical Biotechnology Abstracts KW - Carbapenems KW - Everninomicin KW - Minimum inhibitory concentration KW - Antimicrobial agents KW - Meropenem KW - Antibiotic sensitivity testing KW - Antibacterial agents KW - Drugs KW - W3 33370:Antibiotics KW - W 30965:Miscellaneous, Reviews KW - J 02783:Antibiotics: General KW - A 01074:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17372938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+vitro+activities+of+the+everninomicin+SCH+27899+and+other+newer+antimicrobial+agents+against+Borrelia+burgdorferi&rft.au=Dever%2C+L+L%3BTorigian%2C+C+V%3BBarbour%2C+A+G&rft.aulast=Dever&rft.aufirst=L&rft.date=1999-07-01&rft.volume=43&rft.issue=7&rft.spage=1773&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Borrelia burgdorferi; Everninomicin; Carbapenems; Meropenem; Antibacterial agents; Antibiotic sensitivity testing; Minimum inhibitory concentration; Antimicrobial agents; Drugs ER - TY - JOUR T1 - Lysostaphin treatment of experimental aortic valve endocarditis caused by a Staphylococcus aureus isolate with reduced susceptibility to vancomycin AN - 17281611; 4585342 AB - The rabbit model of endocarditis was used to test the effectiveness of vancomycin and two different lysostaphin dosing regimens for the treatment of infections caused by a Staphylococcus aureus strain with reduced susceptibility to vancomycin (glycopeptide-intermediate susceptible S. aureus [GISA]). Vancomycin was ineffective, with no evidence of sterilization of aortic valve vegetations. However, rates of sterilization of aortic valve vegetations were significantly better for animals treated with either a single dose of lysostaphin (43%) or lysostaphin given twice daily for 3 days (83%) than for animals treated with vancomycin. Rabbits given a single dose of lysostaphin followed by a 3-day drug-free period had mean reductions in aortic valve vegetation bacterial counts of 7.27 and 6.63 log sub(10) CFU/g compared with those for untreated control rabbits and the vancomycin-treated group, respectively. We conclude that lysostaphin is an effective alternative for the treatment of experimental aortic valve endocarditis caused by a clinical VISA strain. JF - Antimicrobial Agents & Chemotherapy AU - Patron, R L AU - Climo, M W AU - Goldstein, B P AU - Archer, G L AD - McGuire Veterans Affairs Medical Center, 1201 Broad Rock Blvd., Section 111-C, Richmond, VA 23249, USA, Climo.Michael@Richmond.va.gov Y1 - 1999/07// PY - 1999 DA - Jul 1999 SP - 1754 EP - 1755 VL - 43 IS - 7 SN - 0066-4804, 0066-4804 KW - Lysostaphin KW - Rabbit model KW - Microbiology Abstracts B: Bacteriology KW - Colony-forming cells KW - Vancomycin KW - Antibacterial agents KW - Staphylococcus aureus KW - Minimum inhibitory concentration KW - Antibiotic resistance KW - Endocarditis KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17281611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Lysostaphin+treatment+of+experimental+aortic+valve+endocarditis+caused+by+a+Staphylococcus+aureus+isolate+with+reduced+susceptibility+to+vancomycin&rft.au=Patron%2C+R+L%3BClimo%2C+M+W%3BGoldstein%2C+B+P%3BArcher%2C+G+L&rft.aulast=Patron&rft.aufirst=R&rft.date=1999-07-01&rft.volume=43&rft.issue=7&rft.spage=1754&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Staphylococcus aureus; Antibiotic resistance; Endocarditis; Antibacterial agents; Vancomycin; Minimum inhibitory concentration; Colony-forming cells ER - TY - JOUR T1 - Human coronary arteriolar dilation to bradykinin depends on membrane hyperpolarization: contribution of nitric oxide and Ca2+-activated K+ channels. AN - 69837234; 10377076 AB - K+ channel activation in vascular smooth muscle cells (VSMCs) plays a key role in regulating vascular tone. It has been proposed that endothelium-derived hyperpolarizing factor (EDHF) contributes to microvascular dilation more than nitric oxide (NO) does. Whether hyperpolarization is important for coronary arteriolar dilation in humans is not known. Bradykinin (BK), an endogenous vasoactive substance, is released from ischemic myocardium and regulates coronary resistance. Therefore, we tested the effects of inhibiting NO synthase, cyclooxygenase, and K+ channels on the changes in diameter and membrane potential (Em) in response to BK in isolated human coronary microvessels. Arterioles (97+/-4 micrometers; n=120) dissected from human right atrial appendages (n=78) were cannulated at a distending pressure of 60 mm Hg and zero flow. Changes in vessel diameter (video microscopy) and VSMC Em (glass microelectrodes) were measured simultaneously. In vessels constricted and depolarized (Em; -50+/-3 to -28+/-2 mV) with endothelin-1 (ET), dilation to BK was associated with greater membrane hyperpolarization (-48+/-3 mV at 10(-6) mol/L) than dilation to sodium nitroprusside (SNP) (-34+/-2 mV at 10(-4) mol/L) for similar degrees of dilation. Treatment with Nomega-nitro-L-arginine methyl ester (L-NAME; 10(-4) mol/L), an NO synthase inhibitor, partially decreased dilation to BK (maximum dilation 61+/-10% versus control 92+/-4%; P<0.05). Charybdotoxin (CTX; 10(-8) mol/L), a large-conductance Ca2+-activated K+ channel blocker, or apamin (10(-7) mol/L), a small-conductance Ca2+-activated K+ channel blocker, inhibited both dilation (CTX 22+/-6% and apamin 45+/-10% versus control 69+/-6%; P<0.05) and membrane hyperpolarization (CTX -31+/-2 mV and apamin -37+/-2 mV versus control -44+/-2 mV; P<0.05) to BK, whereas glibenclamide (10(-6) mol/L), an ATP-sensitive K+ channel blocker, was without effect. Vasodilation of human coronary arterioles to BK is largely dependent on membrane hyperpolarization by Ca2+-activated K+ channel activation, with apparently less of a role for endothelium-derived NO. This suggests a role for K+ channel activation in regulating human coronary arteriolar tone. JF - Circulation AU - Miura, H AU - Liu, Y AU - Gutterman, D D AD - Veterans Administration Medical Center, the Department of Internal Medicine, and Cardiovascular Center, University of Iowa College of Medicine, Iowa City, Iowa, USA. Y1 - 1999/06/22/ PY - 1999 DA - 1999 Jun 22 SP - 3132 EP - 3138 VL - 99 IS - 24 KW - Cyclooxygenase Inhibitors KW - 0 KW - Endothelin-1 KW - Enzyme Inhibitors KW - Potassium Channel Blockers KW - Potassium Channels KW - Vasodilator Agents KW - Charybdotoxin KW - 115422-61-2 KW - Nitroprusside KW - 169D1260KM KW - Apamin KW - 24345-16-2 KW - Nitric Oxide KW - 31C4KY9ESH KW - Potassium Chloride KW - 660YQ98I10 KW - Bradykinin KW - S8TIM42R2W KW - Calcium KW - SY7Q814VUP KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Indomethacin KW - XXE1CET956 KW - Abridged Index Medicus KW - Index Medicus KW - Muscle, Smooth, Vascular -- physiology KW - NG-Nitroarginine Methyl Ester -- pharmacology KW - Humans KW - Membrane Potentials -- physiology KW - Aged KW - Apamin -- pharmacology KW - Endothelium, Vascular -- chemistry KW - Vasodilator Agents -- pharmacology KW - Endothelium, Vascular -- physiology KW - Indomethacin -- pharmacology KW - Potassium Chloride -- pharmacokinetics KW - Endothelium, Vascular -- drug effects KW - Adult KW - In Vitro Techniques KW - Male KW - Muscle, Smooth, Vascular -- chemistry KW - Muscle, Smooth, Vascular -- drug effects KW - Electrophysiology KW - Charybdotoxin -- pharmacology KW - Cyclooxygenase Inhibitors -- pharmacology KW - Calcium -- physiology KW - Enzyme Inhibitors -- pharmacology KW - Membrane Potentials -- drug effects KW - Middle Aged KW - Nitroprusside -- pharmacology KW - Endothelin-1 -- pharmacology KW - Female KW - Coronary Vessels -- physiology KW - Nitric Oxide -- metabolism KW - Vasodilation -- drug effects KW - Potassium Channels -- physiology KW - Coronary Vessels -- drug effects KW - Bradykinin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69837234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation&rft.atitle=Human+coronary+arteriolar+dilation+to+bradykinin+depends+on+membrane+hyperpolarization%3A+contribution+of+nitric+oxide+and+Ca2%2B-activated+K%2B+channels.&rft.au=Miura%2C+H%3BLiu%2C+Y%3BGutterman%2C+D+D&rft.aulast=Miura&rft.aufirst=H&rft.date=1999-06-22&rft.volume=99&rft.issue=24&rft.spage=3132&rft.isbn=&rft.btitle=&rft.title=Circulation&rft.issn=1524-4539&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-07-08 N1 - Date created - 1999-07-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Direct service connection (posttraumatic stress disorder) [Final rule] AN - 42414767; 21786 AB - This document amends the Department of Veterans Affairs adjudication regulations concerning the type of evidence required to establish service connection for PTSD. This amendment implements a decision by the United States Court of Veterans Appeals which stated that current regulations do not adequately reflect the governing statute. [Adapted from Text, p. 32807] JF - Federal Register AU - United States Department of Veterans Affairs PY - 1999 SP - 32807 EP - 32808 VL - 64 IS - 117 SN - 0097-6326, 0097-6326 KW - Americans KW - Health Care Policy KW - Official Publication KW - PTSD (DSM-IV) KW - United States Department of Veterans Affairs KW - Veterans KW - Veterans Benefits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42414767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apilots&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Federal+Register&rft.atitle=Direct+service+connection+%28posttraumatic+stress+disorder%29+%5BFinal+rule%5D&rft.au=United+States+Department+of+Veterans+Affairs&rft.aulast=United+States+Department+of+Veterans+Affairs&rft.aufirst=&rft.date=1999-06-18&rft.volume=64&rft.issue=117&rft.spage=32807&rft.isbn=&rft.btitle=&rft.title=Federal+Register&rft.issn=00976326&rft_id=info:doi/ LA - English DB - PILOTS: Published International Literature On Traumatic Stress N1 - Date revised - 2016-09-15 N1 - Last updated - 2016-09-15 ER - TY - JOUR T1 - Mycobacterium marinum infection in a renal transplant recipient AN - 17324649; 4588996 AB - Infections with atypical mycobacteria occur more frequently in patients with solid organ transplants than in the normal host. We report a case of cutaneous Mycobacterium marinum. infection in a renal transplant recipient. The patient presented with nodules on the forearm after returning from a fishing trip and was treated for cellulitis without success. Cultures of a biopsy of the lesion grew M. marinum. The patient was treated with ethambutol and ciprofloxacin with a good response; however, 9 months of treatment were required for complete resolution. Immunosuppressive therapy for renal transplantation increases susceptibility to a variety of opportunistic infections. A patient who presents with nodules on the extremities should be questioned regarding contact with fish, aquatic environments, or fish tank water, in which case infection with M. marinum should be considered. The diagnosis and treatment of this infection in transplant recipients is discussed. JF - Transplantation AU - Farooqui, MA AU - Berenson, C AU - Lohr, J W AD - Nephrology Department (111A), Veterans Administration Medical Center, 3495 Bailey Avenue, Buffalo, NY 14215, USA Y1 - 1999/06/15/ PY - 1999 DA - 1999 Jun 15 SP - 1495 EP - 1496 VL - 67 IS - 11 SN - 0041-1337, 0041-1337 KW - Mycobacterium marinum KW - immunology KW - infection KW - man KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Transplantation KW - Kidney transplantation KW - J 02855:Human Bacteriology: Others KW - F 06832:Kidney UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17324649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation&rft.atitle=Mycobacterium+marinum+infection+in+a+renal+transplant+recipient&rft.au=Farooqui%2C+MA%3BBerenson%2C+C%3BLohr%2C+J+W&rft.aulast=Farooqui&rft.aufirst=MA&rft.date=1999-06-15&rft.volume=67&rft.issue=11&rft.spage=1495&rft.isbn=&rft.btitle=&rft.title=Transplantation&rft.issn=00411337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium marinum; Transplantation; Kidney transplantation ER - TY - JOUR T1 - Lexical Priming on Neely's (1977) Paradigm in Parkinson's Disease: Where Do We Stand? AN - 85495765; 200005940 AB - A response is given to Wendy L. Arnott & Helen J. Chenery's (1999) critique of two studies (McDonald, Brown, & Gorell, J. M., 1996; Spicer, Brown, & Gorell, 1994), which used a variant of J. H. Neely's (1977) lexical decision paradigm to study shifts of attention & automatic lexical activation in nondemented individuals with Parkinson's disease. Even when considering the important differences between Neely's (1977) results & those in the control groups of these two studies, it is argued that the results of the two studies support the conclusions of normal automatic semantic activation & deficient set-shifting in Parkinson's disease. In addition, the notion of generalized priming is introduced to account for some of the priming effects observed in these studies. 2 Tables, 2 Figures, 16 References. Adapted from the source document JF - Journal of Clinical and Experimental Neuropsychology AU - Brown, Gregory G AU - McDonald, Cathleen AU - Spicer, Kevin AD - Psychology Service, San Diego Veterans Administration Healthcare System, CA gregb@alive5.ucsd.edu Y1 - 1999/06// PY - 1999 DA - June 1999 SP - 301 EP - 311 VL - 21 IS - 3 SN - 1380-3395, 1380-3395 KW - Priming (67670) KW - Verbal Tasks (93800) KW - Measures (Instruments) (52300) KW - Parkinsons Disease (62800) KW - Attention (05350) KW - Semantic Processing (76760) KW - article KW - 4014: psycholinguistics; semantic processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85495765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+and+Experimental+Neuropsychology&rft.atitle=Lexical+Priming+on+Neely%27s+%281977%29+Paradigm+in+Parkinson%27s+Disease%3A+Where+Do+We+Stand%3F&rft.au=Brown%2C+Gregory+G%3BMcDonald%2C+Cathleen%3BSpicer%2C+Kevin&rft.aulast=Brown&rft.aufirst=Gregory&rft.date=1999-06-01&rft.volume=21&rft.issue=3&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+and+Experimental+Neuropsychology&rft.issn=13803395&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCENE8 N1 - SubjectsTermNotLitGenreText - Verbal Tasks (93800); Semantic Processing (76760); Attention (05350); Parkinsons Disease (62800); Measures (Instruments) (52300); Priming (67670) ER - TY - JOUR T1 - Developmental stuttering and Parkinson's disease: the effects of levodopa treatment. AN - 85260888; pmid-10329754 AB - The effects of dopamine on developmental stuttering was studied in a 44 year old man with developmental stuttering and Parkinson's disease during three levodopa "on" periods and three "off" periods. When compared with the "off" periods, during the "on"' periods he demonstrated an increase of speech dysfluencies. These findings lend support to the dopamine hypothesis of developmental stuttering. JF - Journal of Neurology, Neurosurgery, and Psychiatry AU - Anderson, J M AU - Hughes, J D AU - Rothi L J AU - Crucian, G P AU - Heilman, K M AD - Department of Neurology, University of Florida College of Medicine, Veterans Administration Medical Center, Gainesville, Florida, USA. PY - 1999 SP - 776 EP - 778 VL - 66 IS - 6 SN - 0022-3050, 0022-3050 KW - Levodopa KW - Parkinson Disease KW - Human KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Case Report KW - Stuttering KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85260888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurology%2C+Neurosurgery%2C+and+Psychiatry&rft.atitle=Developmental+stuttering+and+Parkinson%27s+disease%3A+the+effects+of+levodopa+treatment.&rft.au=Anderson%2C+J+M%3BHughes%2C+J+D%3BRothi+L+J%3BCrucian%2C+G+P%3BHeilman%2C+K+M&rft.aulast=Anderson&rft.aufirst=J&rft.date=1999-06-01&rft.volume=66&rft.issue=6&rft.spage=776&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurology%2C+Neurosurgery%2C+and+Psychiatry&rft.issn=00223050&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Tacrolimus and mycophenolate mofetil regimens in transplantation: benefits and pitfalls. AN - 733540077; 18031151 AB - Immunosuppression, although necessary to enable the graft to escape the consequences of immune surveillance, carries some risks for the patient. There is an associated increase in neoplasms, opportunistic infections and end-organ toxicity. In addition, even with excellent patient compliance, rejection (acute and chronic) remains a major limitation that contributes to the loss or decrease in the function of the allograft. New drugs have been added to the armamentarium of immunosuppressive agents to suppress allograft rejection and to rescue grafts from cyclosporin-resistant rejection. With the availability of these immunosuppressive agents, it has become increasingly difficult to choose the appropriate combination of immunosuppressants with a beneficial effect for the patient and for the allograft. We describe 2 new immunosuppressive agents and some of their different uses in solid organ transplantation. JF - BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy AU - Ciancio, G AU - Burke, G W AU - Roth, D AU - Miller, J AD - University of Miami School of Medicine, and the Miami Veterans Administration, Medical Center, Miami, Florida, USA. gciancio@mednet.med.miami.edu Y1 - 1999/06// PY - 1999 DA - June 1999 SP - 395 EP - 407 VL - 11 IS - 6 SN - 1173-8804, 1173-8804 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733540077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioDrugs+%3A+clinical+immunotherapeutics%2C+biopharmaceuticals+and+gene+therapy&rft.atitle=Tacrolimus+and+mycophenolate+mofetil+regimens+in+transplantation%3A+benefits+and+pitfalls.&rft.au=Ciancio%2C+G%3BBurke%2C+G+W%3BRoth%2C+D%3BMiller%2C+J&rft.aulast=Ciancio&rft.aufirst=G&rft.date=1999-06-01&rft.volume=11&rft.issue=6&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=BioDrugs+%3A+clinical+immunotherapeutics%2C+biopharmaceuticals+and+gene+therapy&rft.issn=11738804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-20 N1 - Date created - 2007-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diet, amyloid enhancing factor (AEF) and amyloidogenesis: an hypothesis. AN - 69952805; 10439116 AB - At least two forms of amyloidosis, amyloid A (AA) and prion protein (PrP), can be transmitted by dietary ingestion of an agent(s) present in crude mammalian tissues. Although the incubation time for PrP or scrapie-induced diseases to develop in experimental animals extends over months or years, AA or secondary amyloidosis in mice is inducible within a week. In response to inflammatory stimuli we hypothesize that dietary factor(s) modulate the rate at which beta-pleated sheet fibrils accumulate in most forms of amyloidosis. The critical importance of precursor protein polymorphism, cell surface proteoglycans (PG), lipids and apolipoprotein metabolism has also been addressed in this hypothesis. JF - Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis AU - Cathcart, E S AU - Elliott-Bryant, R AD - Department of Medicine, Boston University School of Medicine, MA 02154, USA. cathcart,edgar@bedford.va.gov Y1 - 1999/06// PY - 1999 DA - June 1999 SP - 107 EP - 113 VL - 6 IS - 2 SN - 1350-6129, 1350-6129 KW - Amyloid KW - 0 KW - Glycoproteins KW - Prions KW - amyloid enhancing factor KW - Index Medicus KW - Prions -- adverse effects KW - Animals KW - Mice, Inbred C57BL KW - Mice KW - Amyloid -- biosynthesis KW - Glycoproteins -- metabolism KW - Amyloidosis -- etiology KW - Amyloidosis -- chemically induced KW - Diet KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69952805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Amyloid+%3A+the+international+journal+of+experimental+and+clinical+investigation+%3A+the+official+journal+of+the+International+Society+of+Amyloidosis&rft.atitle=Diet%2C+amyloid+enhancing+factor+%28AEF%29+and+amyloidogenesis%3A+an+hypothesis.&rft.au=Cathcart%2C+E+S%3BElliott-Bryant%2C+R&rft.aulast=Cathcart&rft.aufirst=E&rft.date=1999-06-01&rft.volume=6&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Amyloid+%3A+the+international+journal+of+experimental+and+clinical+investigation+%3A+the+official+journal+of+the+International+Society+of+Amyloidosis&rft.issn=13506129&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-09-14 N1 - Date created - 1999-09-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Etiology and pathogenesis of airway disease in children and adults from rural communities. AN - 69932395; 10346988 AB - Asthma is the most common chronic disease of childhood and affects nearly 5 million children. The prevalence and severity of childhood asthma have continued to increase over the past decade despite major advances in the recognition and treatment of this condition. A comparison of urban and rural children suggests that the etiology of airway disease is multifactorial and that unique exposures and genetic factors contribute to the development of asthma in both settings. The most important environmental exposure that distinguishes the rural environment and is known to cause asthma is the organic dusts. However, animal-derived proteins, common allergens, and low concentrations of irritants also contribute to the development of airway disease in children and adults living in rural communities. A fundamental unanswered question regarding asthma is why only a minority of children who wheeze at an early age develop persistent airway disease that continues throughout their life. Although genetic factors are important in the development of asthma, recurrent airway inflammation, presumably mediated by environmental exposures, may result in persistent airway hyperresponsiveness and the development of chronic airway disease. Increasing evidence indicates that control of the acute inflammatory response substantially improves airflow and reduces chronic airway remodeling. Reducing exposure to agricultural dusts and treatment with anti-inflammatory medication is indicated in most cases of childhood asthma. In addition, children with asthma from rural (in comparison to urban) America face multiple barriers that adversely affect their health e.g., more poverty, geographic barriers to health care, less health insurance, and poorer access to health care providers. These unique problems must be considered in developing interventions that effectively reduce the morbidity and mortality of asthma in children from rural communities. JF - Environmental health perspectives AU - Schwartz, D A AD - Veterans Administration Medical Center, Iowa City, IA 52242, USA. david-schwartz@uiowa.edu Y1 - 1999/06// PY - 1999 DA - June 1999 SP - 393 EP - 401 VL - 107 Suppl 3 SN - 0091-6765, 0091-6765 KW - Cytokines KW - 0 KW - Dust KW - RNA, Messenger KW - Index Medicus KW - United States KW - Rural Health KW - Animals KW - Cytokines -- genetics KW - RNA, Messenger -- metabolism KW - Humans KW - Adult KW - Environmental Exposure KW - Child KW - RNA, Messenger -- genetics KW - Dust -- adverse effects KW - Urban Population KW - Health Services Accessibility KW - Asthma -- etiology KW - Asthma -- genetics KW - Asthma -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69932395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Etiology+and+pathogenesis+of+airway+disease+in+children+and+adults+from+rural+communities.&rft.au=Schwartz%2C+D+A&rft.aulast=Schwartz&rft.aufirst=D&rft.date=1999-06-01&rft.volume=107+Suppl+3&rft.issue=&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-08-29 N1 - Date created - 2000-08-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Environ Health. 1981 Mar-Apr;36(2):75-81 [7212779] J Air Pollut Control Assoc. 1981 Mar;31(3):236-40 [7229222] Clin Immunol Immunopathol. 1981 Nov;21(2):141-53 [6794964] Am Rev Respir Dis. 1981 Dec;124(6):673-80 [7316271] Chest. 1982 Jan;81(1):55-61 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1987 Jun;91(6 Suppl):65S-74S [3581966] Environ Res. 1987 Aug;43(2):317-31 [3608935] N Engl J Med. 1987 Sep 3;317(10):605-10 [3614274] Am Rev Respir Dis. 1987 Nov;136(5):1174-8 [3674580] Clin Sci (Lond). 1987 Dec;73(6):561-72 [3319356] Ann Allergy. 1987 Dec;59(6):405-14 [3122604] N Engl J Med. 1989 Apr 27;320(17):1097-102 [2710172] Am Rev Respir Dis. 1989 Jul;140(1):179-84 [2751164] Am Rev Respir Dis. 1989 Oct;140(4):981-6 [2508526] Br J Ind Med. 1989 Jun;46(6):412-6 [2818976] Am Rev Respir Dis. 1989 Dec;140(6):1745-53 [2690708] Med J Aust. 1990 Jun 4;152(11):578-82 [2190075] Am Rev Respir Dis. 1990 Jul;142(1):126-32 [2368958] Am Rev Respir Dis. 1990 Jul;142(1):184-92 [2368968] Am Rev Respir Dis. 1990 Aug;142(2):434-57 [2200318] Chest. 1990 Sep;98(3):536-42 [2168308] JAMA. 1990 Oct 3;264(13):1683-7 [2398607] N Engl J Med. 1990 Oct 11;323(15):1033-9 [2215562] Am Rev Respir Dis. 1990 Oct;142(4):832-6 [2221590] Am Rev Respir Dis. 1990 Oct;142(4):863-71 [2221594] Am J Respir Cell Mol Biol. 1990 Nov;3(5):507-11 [2223105] Am J Respir Crit Care Med. 1994 Nov;150(5 Pt 1):1250-5 [7952548] Am J Physiol. 1994 Nov;267(5 Pt 1):L609-17 [7977771] N Engl J Med. 1995 Jan 19;332(3):133-8 [7800004] Am J Respir Crit Care Med. 1995 Jan;151(1):47-53 [7812571] N Engl J Med. 1995 Jul 13;333(2):107-12 [7777015] Am J Respir Crit Care Med. 1995 Aug;152(2):603-8 [7633714] J Immunol. 1995 Aug 15;155(4):2222-9 [7636269] Br J Ind Med. 1969 Oct;26(4):314-21 [4899667] J Chronic Dis. 1971 Sep;24(7):469-87 [4257610] Acta Morphol Acad Sci Hung. 1972;20(3):191-7 [4592087] Am Rev Respir Dis. 1976 Nov;114(5):1011-9 [988767] Arch Environ Health. 1977 Jan-Feb;32(1):4-13 [836085] J Occup Med. 1978 Jan;20(1):30-2 [621592] Arch Environ Health. 1978 Nov-Dec;33(6):313-7 [736615] Chest. 1979 Apr;75(4):461-7 [446134] Chest. 1990 Nov;98(5 Suppl):148S-161S [2226002] Chest. 1990 Nov;98(5 Suppl):191S-195S [2226008] J Clin Invest. 1991 Jan;87(1):148-54 [1702097] Am J Respir Cell Mol Biol. 1991 Jan;4(1):65-71 [1846078] JAMA. 1991 Aug 7;266(5):670-5 [2072477] J Biol Chem. 1991 Oct 15;266(29):19611-7 [1918068] Am Rev Respir Dis. 1992 Jan;145(1):58-64 [1731600] Am Rev Respir Dis. 1992 Feb;145(2 Pt 1):332-6 [1736737] Ann Intern Med. 1992 Apr 15;116(8):630-5 [1546862] Am Rev Respir Dis. 1992 Apr;145(4 Pt 1):890-9 [1554218] Chest. 1992 Oct;102(4):1095-8 [1395750] Am Rev Respir Dis. 1993 Jan;147(1):111-7 [8420403] Am Rev Respir Dis. 1992 Aug;146(2):352-7 [1489124] J Paediatr Child Health. 1995 Jun;31(3):213-7 [7669382] Indian J Med Res. 1995 Jun;101:238-44 [7672833] Chest. 1996 Mar;109(3 Suppl):57S-63S [8598158] Am J Respir Crit Care Med. 1996 May;153(5):1553-9 [8630601] Chest. 1996 Apr;109(4):1086-92 [8635334] Chest. 1996 Jul;110(1):263-70 [8681637] Am J Respir Crit Care Med. 1996 Nov;154(5):1261-6 [8912733] Am J Respir Crit Care Med. 1997 Jan;155(1):254-9 [9001321] Thorax. 1997 Mar;52(3):218-22 [9093335] Thorax. 1997 Mar;52(3):223-8 [9093336] Chest. 1997 Apr;111(4):852-7 [9106559] Am J Respir Crit Care Med. 1997 Jul;156(1):314-9 [9230768] Am J Respir Cell Mol Biol. 1997 Sep;17(3):326-33 [9308919] Am J Respir Crit Care Med. 1997 Dec;156(6):1863-9 [9412567] Am J Physiol. 1998 Jan;274(1 Pt 1):L26-31 [9458797] Am J Respir Crit Care Med. 1998 Apr;157(4 Pt 1):1073-8 [9563721] Ann Allergy Asthma Immunol. 1998 Oct;81(4):322-5 [9809495] Arch Environ Health. 1998 May-Jun;53(3):222-30 [9814719] Eur Respir J. 1998 Nov;12(5):1105-12 [9864005] J Occup Environ Med. 1998 Dec;40(12):1048-52 [9871880] Ann Allergy. 1961 Apr;19:397-401 [13783892] J Clin Pathol. 1960 Jan;13:27-33 [13818688] Chest. 1993 Feb;103(2 Suppl):125S-128S [8428534] West J Med. 1993 Jan;158(1):56-63 [8470386] J Infect Dis. 1993 Jun;167(6):1464-6 [8501341] Am Rev Respir Dis. 1993 Aug;148(2):401-6 [8342904] Chest. 1993 Sep;104(3):825-30 [8365296] Am Rev Respir Dis. 1993 Sep;148(3):667-70 [8368638] J Clin Invest. 1994 Jan;93(1):26-32 [8282796] Am J Respir Cell Mol Biol. 1994 Feb;10(2):214-21 [8110477] Am J Ind Med. 1994 Jan;25(1):85-8 [8116660] Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):584-90 [8118622] Ann Allergy. 1994 Mar;72(3):203-8 [8129212] N Engl J Med. 1994 Sep 15;331(11):700-5 [8058076] Am J Respir Crit Care Med. 1994 Sep;150(3):611-7 [8087327] N Engl J Med. 1994 Nov 10;331(19):1286-92 [7935686] Am Rev Respir Dis. 1988 Jan;137(1):62-9 [2447813] Comp Immunol Microbiol Infect Dis. 1987;10(3-4):219-26 [3501358] J Allergy Clin Immunol. 1988 Aug;82(2):251-5 [3042839] Am Rev Respir Dis. 1988 Oct;138(4):921-7 [3059885] Proc Natl Acad Sci U S A. 1989 Jan;86(2):612-6 [2643119] Thorax. 1988 Nov;43(11):872-7 [3222758] Eur Respir J. 1988 Dec;1(10):883-9 [3224689] Br J Ind Med. 1989 Jan;46(1):31-7 [2920141] Lancet. 1989 Mar 11;1(8637):520-4 [2466184] Am Rev Respir Dis. 1989 Mar;139(3):806-17 [2923380] J Appl Physiol (1985). 1989 Mar;66(3):1059-64 [2708231] Clin Allergy. 1979 May;9(3):229-36 [466751] J Occup Med. 1979 May;21(5):342-6 [469595] Clin Allergy. 1979 Jul;9(4):319-4 [476905] Chest. 1980 Jan;77(1):28-31 [7351141] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An experimental basis for implicating excitotoxicity in glaucomatous optic neuropathy. AN - 69901288; 10416757 AB - Most therapy for glaucoma is directed at the management of the intraocular pressure (IOP). Conventional wisdom holds that excessive pressure within the eye leads to the ganglion cell loss/optic nerve damage seen in this disease. Both glutamate and elevated IOP can selectively damage the retinal ganglion cells in the mammalian eye. We have identified an elevated level of glutamate in the vitreous humor of glaucoma patients (27 microM as compared to 11 microM in the control population). This concentration of glutamate suffices--on its own--to kill retinal ganglion cells. It is plausible that the IOP may represent an initial insult that precipitates the production of excessive glutamate. Therefore, even if glutamate elevation is an epiphenomenon associated with the course of the disease, it may contribute to ganglion cell loss in humans. Lowering the IOP may slow down glutamate production, but if nothing is done to block the toxic effects of glutamate as well, visual loss may result despite excellent IOP control. If interventions can be found to retard the production or toxic effects of glutamate, it may be possible to slow glaucomatous visual loss. JF - Survey of ophthalmology AU - Vorwerk, C K AU - Gorla, M S AU - Dreyer, E B AD - Scheie Eye Institute and Philadelphia Veterans Administration, Department of Ophthalmology, University of Pennsylvania, 19104, USA. Y1 - 1999/06// PY - 1999 DA - June 1999 SP - S142 EP - S150 VL - 43 Suppl 1 SN - 0039-6257, 0039-6257 KW - Enzyme Inhibitors KW - 0 KW - Neuroprotective Agents KW - Glutamic Acid KW - 3KX376GY7L KW - N-Methylaspartate KW - 6384-92-5 KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Index Medicus KW - Animals KW - Intraocular Pressure KW - N-Methylaspartate -- metabolism KW - Enzyme Inhibitors -- therapeutic use KW - Vitreous Body -- metabolism KW - Humans KW - Retinal Ganglion Cells -- pathology KW - Nitric Oxide Synthase -- antagonists & inhibitors KW - Apoptosis -- drug effects KW - N-Methylaspartate -- antagonists & inhibitors KW - Retinal Ganglion Cells -- drug effects KW - Neuroprotective Agents -- therapeutic use KW - Nitric Oxide Synthase -- metabolism KW - Glaucoma -- drug therapy KW - Glaucoma -- complications KW - Optic Nerve Diseases -- metabolism KW - Glutamic Acid -- metabolism KW - Optic Nerve Diseases -- etiology KW - Optic Nerve Diseases -- drug therapy KW - Glaucoma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69901288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Survey+of+ophthalmology&rft.atitle=An+experimental+basis+for+implicating+excitotoxicity+in+glaucomatous+optic+neuropathy.&rft.au=Vorwerk%2C+C+K%3BGorla%2C+M+S%3BDreyer%2C+E+B&rft.aulast=Vorwerk&rft.aufirst=C&rft.date=1999-06-01&rft.volume=43+Suppl+1&rft.issue=&rft.spage=S142&rft.isbn=&rft.btitle=&rft.title=Survey+of+ophthalmology&rft.issn=00396257&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-09-13 N1 - Date created - 1999-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Emerging research on the treatment of Gulf War veterans' illnesses. AN - 69863299; 10390694 AB - Much of what is known about Gulf War veterans' illnesses is a result of the investment in research by the federal government. Since 1993, the Research Working Group of the Federal Interagency Persian Gulf Veterans Coordinating Board has guided the federal research program. Based on this research, Hodgson and Kipin conclude that the symptom-based conditions reported by Gulf War veterans could be treated through the use of a technique called cognitive behavioral therapy. This past year, the Department of Veterans Affairs launched the largest multisite, randomized, controlled treatment trial of the effectiveness of exercise and cognitive behavioral therapy in relieving the symptoms of ill Gulf War veterans. Despite this important step forward, the Department and its Research Working Group partners continue to explore all aspects of Gulf War veterans' illnesses. JF - Journal of occupational and environmental medicine AU - Gerrity, T R AU - Feussner, J R AD - Office of Research and Development (12G), Veterans Health Administration, US Department of Veterans Affairs, Washington, DC 20420, USA. Y1 - 1999/06// PY - 1999 DA - June 1999 SP - 440 EP - 442 VL - 41 IS - 6 SN - 1076-2752, 1076-2752 KW - Index Medicus KW - Humans KW - Adult KW - Research Design KW - Male KW - Female KW - Military Medicine KW - Veterans KW - Cognitive Therapy KW - Persian Gulf Syndrome -- therapy KW - Persian Gulf Syndrome -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69863299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Emerging+research+on+the+treatment+of+Gulf+War+veterans%27+illnesses.&rft.au=Gerrity%2C+T+R%3BFeussner%2C+J+R&rft.aulast=Gerrity&rft.aufirst=T&rft.date=1999-06-01&rft.volume=41&rft.issue=6&rft.spage=440&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-08-17 N1 - Date created - 1999-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Overview of psychiatric comorbidity. Practical and theoretic considerations. AN - 69851209; 10385937 AB - Psychiatric comorbidity is a common clinical challenge for addiction therapists. The clinician is challenged by the assessment as well as the ongoing management of such cases. Stabilization is complicated by the comorbid problems. Careful use of psychiatric medications can be helpful and collaboration with other health care professionals is usually an important aspect of treatment with this population. There is much evidence that treatment of addiction is cost-effective and some evidence that treatment of dual conditions is also cost-effective. JF - The Psychiatric clinics of North America AU - Goldsmith, R J AD - Department of Psychiatry, University of Cincinnati College of Medicine, Ohio, USA. Goldsmith.Richard_J@cincinnati.va.gov Y1 - 1999/06// PY - 1999 DA - June 1999 SP - 331 EP - 49, ix VL - 22 IS - 2 SN - 0193-953X, 0193-953X KW - Index Medicus KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Psychotherapy -- methods KW - Comorbidity KW - Cost-Benefit Analysis KW - Risk Factors KW - Treatment Outcome KW - Practice Guidelines as Topic KW - Anxiety Disorders -- epidemiology KW - Mood Disorders -- epidemiology KW - Schizophrenia -- epidemiology KW - Sex Distribution KW - Secondary Prevention KW - Female KW - Male KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Mental Disorders -- diagnosis KW - Mental Disorders -- epidemiology KW - Substance-Related Disorders -- economics KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69851209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Psychiatric+clinics+of+North+America&rft.atitle=Overview+of+psychiatric+comorbidity.+Practical+and+theoretic+considerations.&rft.au=Goldsmith%2C+R+J&rft.aulast=Goldsmith&rft.aufirst=R&rft.date=1999-06-01&rft.volume=22&rft.issue=2&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=The+Psychiatric+clinics+of+North+America&rft.issn=0193953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-08-12 N1 - Date created - 1999-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of Arsenite on Induction of CYP1A, CYP2B, and CYP3A in Primary Cultures of Rat Hepatocytes AN - 17232036; 4509189 AB - In earlier studies, sodium arsenite treatment was shown to decrease induction of enzymatic activities associated with hepatic CYPs in rats. Here we investigated the effect of sodium arsenite on induction of CYP2B, CYP1A, and CYP3A in primary cultures of rat hepatocytes. Arsenite decreased the induction of all three families of CYP, as measured enzymatically and immunochemically. These decreases in CYPs occurred at concentrations of arsenite (2.5-10 mu M) at which no toxicity was observed; however, toxicity was observed at 25 mu M arsenite. With 3-methylcholanthrene as inducer, 5 mu M arsenite caused a 55% decrease in CYP1A1 immunoreactive protein and enzyme activity, but only a 25% decrease in CYP1A1 mRNA. With phenobarbital (PB) as the inducer, 2.5 mu M arsenite decreased CYP2B enzyme activity and immunoreactive protein 50%, with only a 25% decrease in CYP2B1 mRNA. 5 mu M Arsenite decreased CYP2B enzyme activity and immunoreactive protein 80%, but decreased CYP2B1 mRNA only 50%, while CYP3A protein was decreased greater than 75% with no decrease in CYP3A23 mRNA. With dexamethasone (DEX) as inducer, 5 mu M sodium arsenite caused a 50% decrease in immunoreactive CYP3A and a 30% decrease in CYP3A23 mRNA. Although arsenite-mediated increases in heme oxygenase (HO) inversely correlated with decreases in CYP2B or CYP1A activity, inclusion of heme in cultures treated with inducers of CYP1A or CYP2B did not prevent the arsenite-mediated decreases in these CYPs. Even though added heme induced HO to similar levels with and without arsenite, decreases in CYPs were only observed in the presence of arsenite. These results suggest that, in rat hepatocytes, elevated levels of HO alone are not responsible for arsenite-mediated decreases in CYP. JF - Toxicology and Applied Pharmacology AU - Jacobs, J M AU - Nichols, CE AU - Andrew, A S AU - Marek, DE AU - Wood, S G AU - Sinclair, PR AU - Wrighton, SA AU - Kostrubsky, V E AU - Sinclair, J F AD - Veterans Administration Medical Center, White River Junction, Vermont Y1 - 1999/05/15/ PY - 1999 DA - 1999 May 15 SP - 51 EP - 59 PB - Academic Press VL - 157 IS - 1 SN - 0041-008X, 0041-008X KW - cytochrome P450 KW - enzymatic activity KW - rats KW - Toxicology Abstracts KW - Hepatocytes KW - Arsenite KW - Heme oxygenase (decyclizing) KW - X 24163:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17232036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Effect+of+Arsenite+on+Induction+of+CYP1A%2C+CYP2B%2C+and+CYP3A+in+Primary+Cultures+of+Rat+Hepatocytes&rft.au=Jacobs%2C+J+M%3BNichols%2C+CE%3BAndrew%2C+A+S%3BMarek%2C+DE%3BWood%2C+S+G%3BSinclair%2C+PR%3BWrighton%2C+SA%3BKostrubsky%2C+V+E%3BSinclair%2C+J+F&rft.aulast=Jacobs&rft.aufirst=J&rft.date=1999-05-15&rft.volume=157&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Arsenite; Hepatocytes; Heme oxygenase (decyclizing) ER - TY - JOUR T1 - Clinical presentation and management of labyrinthine fistula caused by chronic otitis media. AN - 85300423; pmid-10335702 AB - To describe the clinical presentation and surgical management of patients with chronic otitis media complicated by labyrinthine fistula and to determine clinical indicators that predict postoperative hearing outcome, I performed a retrospective analysis at an academic tertiary care center. Thirty-four patients with labyrinthine fistula as a complication of chronic otitis media, documented at mastoidectomy, underwent postoperative audiometry. The median age was 50 years, and the duration of otologic symptoms ranged from 2 months to more than 40 years. On presentation, 3 patients had anacusis in the affected ear, while in the others, the pure tone average for bone conduction at the 0.5-, 1-, 2-, and 4-kHz frequencies was 34 dB hearing level. Nineteen patients (56%) complained of dizziness on presentation. The fistula test was positive in 14 of 28 patients (50%). The fistula was detected radiologically in 10 of 24 patients (42%). Cholesteatoma was present in 33 of 34 patients (97%). The lateral semicircular canal was the most common site of labyrinthine fistula. The cholesteatoma matrix was completely removed in 29 of 33 cases and exteriorized in the remaining 4. Of the 31 patients with measurable hearing preoperatively, anacusis occurred in 8 (26%). In 6 of these, the preoperative pure tone average for bone conduction was greater than 50 dB hearing level, and cholesteatoma matrix and granulation tissue invading the membranous labyrinth were found at surgery. I concluded that in chronic otitis media, labyrinthine fistulas occurred almost exclusively in the presence of a cholesteatoma. Postoperative hearing outcome correlated with the size of the fistula and the presence of granulation tissue invading the labyrinth. which could be predicted by the preoperative audiometry. JF - The Annals of otology, rhinology, and laryngology AU - Busaba, N Y AD - Division of Otolaryngology, Brockton/West Roxbury Veterans Administration Medical Center, West Roxbury, Massachusetts, USA. Y1 - 1999/05// PY - 1999 DA - May 1999 SP - 435 EP - 439 VL - 108 IS - 5 SN - 0003-4894, 0003-4894 KW - Abridged Index Medicus; Index Medicus KW - National Library of Medicine KW - Labyrinth Diseases -- etiology KW - Audiometry KW - Humans KW - Labyrinth Diseases -- surgery KW - Retrospective Studies KW - Labyrinth Diseases -- diagnosis KW - Aged KW - Aged, 80 and over KW - Adult KW - Fistula -- etiology KW - Cholesteatoma, Middle Ear -- complications KW - Chronic Disease KW - Middle Aged KW - Adolescent KW - Fistula -- diagnosis KW - Fistula -- surgery KW - Male KW - Female KW - Otitis Media -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85300423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.atitle=Clinical+presentation+and+management+of+labyrinthine+fistula+caused+by+chronic+otitis+media.&rft.au=Busaba%2C+N+Y&rft.aulast=Busaba&rft.aufirst=N&rft.date=1999-05-01&rft.volume=108&rft.issue=5&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.issn=00034894&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-01-15 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Neuropsychological deficits in withdrawn cocaine-dependent males. AN - 69876486; 10395167 AB - Previous research suggests that cocaine abuse may result in neuropsychological deficits. To examine this further, we compared cocaine-withdrawn patients (N = 35) to normal controls (N = 17) on tasks of attention, concentration, perceptual-motor speed, and cognitive flexibility. The withdrawn cocaine patients performed significantly worse on Arithmetic, Grooved Peg Board Dominant and Non-Dominant, and Trails B tests. These findings suggest that withdrawn cocaine-dependent patients have more neuropsychological impairment than normal controls. JF - The American journal of drug and alcohol abuse AU - Smelson, D A AU - Roy, A AU - Santana, S AU - Engelhart, C AD - New Jersey Veterans Administration Medical Center, Robert Wood Johnson Medical School Department of Psychiatry, USA. Y1 - 1999/05// PY - 1999 DA - May 1999 SP - 377 EP - 381 VL - 25 IS - 2 SN - 0095-2990, 0095-2990 KW - Index Medicus KW - Severity of Illness Index KW - Humans KW - Adult KW - Neuropsychological Tests KW - Male KW - Substance Withdrawal Syndrome -- complications KW - Cognition Disorders -- etiology KW - Cognition Disorders -- diagnosis KW - Cocaine-Related Disorders -- psychology KW - Substance Withdrawal Syndrome -- psychology KW - Cocaine-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69876486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Neuropsychological+deficits+in+withdrawn+cocaine-dependent+males.&rft.au=Smelson%2C+D+A%3BRoy%2C+A%3BSantana%2C+S%3BEngelhart%2C+C&rft.aulast=Smelson&rft.aufirst=D&rft.date=1999-05-01&rft.volume=25&rft.issue=2&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-10-01 N1 - Date created - 1999-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethanol feeding does not affect the efficacy or pharmacokinetics of azithromycin, trovafloxacin, or ceftriaxone in a rat model of pneumococcal pneumonia. AN - 69820628; 10371404 AB - A rat model of ethanol feeding was used to study the effects of ethanol on antibiotic therapy of pneumococcal pneumonia. Male Sprague-Dawley rats (150 g) received a liquid diet containing 36% of total calories as ethanol. Controls were pair-fed a liquid diet without ethanol or received rat chow. Diets began 7 days pre- and continued postinfection. Rats were infected transtracheally with type 3 Streptococcus pneumoniae and then treated with azithromycin (50 mg/kg), trovafloxacin (50 mg/kg), or ceftriaxone (100 mg/kg) injected subcutaneously twice daily for 5 days. Antibiotic levels in serum, lung cells, and lavage fluid were measured by HPLC. Ethanol- and pair-fed rats had depressed baseline peripheral neutrophil counts but were able to generate adequate numbers of peripheral and pulmonary polymorphonuclear leukocytes early in the course of their infection. Ethanol feeding did not alter the pharmacokinetics of azithromycin, trovafloxacin, or ceftriaxone. All three antibiotics were equally effective in curing experimental pneumococcal pneumonia, and survival rates were similar in treated ethanol-fed and control rats. JF - Alcoholism, clinical and experimental research AU - Preheim, L C AU - Olsen, K M AU - Yue, M AU - Snitily, M U AU - Gentry, M J AD - Infectious Diseases Section, Veterans Affairs Medical Center, Creighton University School of Medicine, Omaha, Nebraska 68105, USA. preheim@omaha.va.gov Y1 - 1999/05// PY - 1999 DA - May 1999 SP - 842 EP - 849 VL - 23 IS - 5 SN - 0145-6008, 0145-6008 KW - Anti-Infective Agents KW - 0 KW - Fluoroquinolones KW - Naphthyridines KW - Ethanol KW - 3K9958V90M KW - Ceftriaxone KW - 75J73V1629 KW - Azithromycin KW - 83905-01-5 KW - trovafloxacin KW - 9F388J00UK KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Neutrophils KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Bronchoalveolar Lavage Fluid -- microbiology KW - Bronchoalveolar Lavage Fluid -- cytology KW - Male KW - Leukocyte Count KW - Anti-Infective Agents -- pharmacokinetics KW - Azithromycin -- pharmacokinetics KW - Naphthyridines -- pharmacokinetics KW - Ethanol -- pharmacology KW - Feeding Behavior -- physiology KW - Ethanol -- administration & dosage KW - Pneumonia, Pneumococcal -- drug therapy KW - Disease Models, Animal KW - Pneumonia, Pneumococcal -- blood KW - Ceftriaxone -- pharmacokinetics KW - Azithromycin -- therapeutic use KW - Naphthyridines -- therapeutic use KW - Anti-Infective Agents -- therapeutic use KW - Ethanol -- adverse effects KW - Pneumonia, Pneumococcal -- metabolism KW - Ceftriaxone -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69820628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Ethanol+feeding+does+not+affect+the+efficacy+or+pharmacokinetics+of+azithromycin%2C+trovafloxacin%2C+or+ceftriaxone+in+a+rat+model+of+pneumococcal+pneumonia.&rft.au=Preheim%2C+L+C%3BOlsen%2C+K+M%3BYue%2C+M%3BSnitily%2C+M+U%3BGentry%2C+M+J&rft.aulast=Preheim&rft.aufirst=L&rft.date=1999-05-01&rft.volume=23&rft.issue=5&rft.spage=842&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-08-17 N1 - Date created - 1999-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improving cost-effectiveness in a substance abuse treatment program. AN - 69766187; 10332897 JF - Psychiatric services (Washington, D.C.) AU - Francis, E AU - Hughes, P AU - Schinka, J AD - Mental Health and Behavioral Sciences Service, Department of Veterans Affairs James A. Haley Health Care System, Tampa, FL 33612, USA. francis.elie_m@tampa.va.gov Y1 - 1999/05// PY - 1999 DA - May 1999 SP - 633 EP - 635 VL - 50 IS - 5 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - United States KW - Ambulatory Care -- economics KW - United States Department of Veterans Affairs KW - Humans KW - Cost-Benefit Analysis KW - Program Development KW - Needs Assessment KW - Hospital Restructuring -- methods KW - Substance-Related Disorders -- therapy KW - Substance Abuse Treatment Centers -- organization & administration KW - Hospital Restructuring -- economics KW - Mental Health Services -- economics KW - Hospitals, Veterans -- organization & administration KW - Substance-Related Disorders -- economics KW - Substance Abuse Treatment Centers -- economics KW - Hospitals, Veterans -- economics KW - Mental Health Services -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69766187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Improving+cost-effectiveness+in+a+substance+abuse+treatment+program.&rft.au=Francis%2C+E%3BHughes%2C+P%3BSchinka%2C+J&rft.aulast=Francis&rft.aufirst=E&rft.date=1999-05-01&rft.volume=50&rft.issue=5&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-07-14 N1 - Date created - 1999-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prophylactic Magnesium to Decrease the Arrhythmogenic Potential of Class III Antiarrhythmic Agents in a Rabbit Model AN - 17269602; 4572343 AB - We assessed the prophylactic effect of intravenous magnesium sulfate on the occurrence of torsades de pointes and early after-depolarizations, and on the QT interval (QTc) in an established rabbit model. Ten rabbits were given intravenous methoxamine to slow their heart rates. After 12 minutes five animals received a 60-mg/kg bolus and continuous infusion of magnesium 0.6 mg/kg/minute, and five received equivolume normal saline concurrently with the class III antiarrhythmic agent clofilium 5 mg/kg over 30 minutes. Electrocardiogram lead II and the monophasic action potential were recorded continuously throughout the experiment. The magnesium group experienced significantly less torsades de pointes and early after-depolarizations than the normal saline group (1/5 and 5/5 both parameters, respectively, p=0.048). There were no differences between groups in QT or QTc interval at baseline or at maximum QT or QTc prolongation. Magnesium decreases the occurrence of torsades de pointes without affecting the QT or QTc interval but does decrease the occurrence of early after-depolarizations. These findings must be validated in human studies. JF - Pharmacotherapy AU - White, C M AU - Xie, P J AU - Chow, MSS AU - Kluger, J AD - Pharmacy Services 119, Veterans Administration Medical Center, 950 Campbell Avenue, West Haven, CT 06516, USA Y1 - 1999/05// PY - 1999 DA - May 1999 SP - 635 EP - 640 VL - 19 IS - 5 SN - 0277-0008, 0277-0008 KW - rabbits KW - Toxicology Abstracts KW - Arrhythmia KW - Magnesium KW - Antiarrhythmic agents KW - X 24111:Acute exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17269602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Prophylactic+Magnesium+to+Decrease+the+Arrhythmogenic+Potential+of+Class+III+Antiarrhythmic+Agents+in+a+Rabbit+Model&rft.au=White%2C+C+M%3BXie%2C+P+J%3BChow%2C+MSS%3BKluger%2C+J&rft.aulast=White&rft.aufirst=C&rft.date=1999-05-01&rft.volume=19&rft.issue=5&rft.spage=635&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Magnesium; Antiarrhythmic agents; Arrhythmia ER - TY - JOUR T1 - Activities of several novel oxazolidinones against Mycobacterium tuberculosis in a murine model AN - 17253082; 4526469 AB - The activities of linezolid, eperezolid, and PNU-100480 were evaluated in a murine model of tuberculosis. Approximately 10 super(7) viable Mycobacterium tuberculosis ATCC 35801 organisms were given intravenously to 4-week-old outbred CD-1 mice. In the first study, treatment was started 1 day postinfection and was given by gavage for 4 weeks. Viable cell counts were determined from homogenates of spleens and lungs. PNU-100480 was as active as isoniazid. Linezolid was somewhat less active than PNU-100480 and isoniazid. Eperezolid had little activity in this model. In the next two studies, treatment was started 1 week postinfection. A dose-response study was performed with PNU-100480 and linezolid (both at 25, 50, and 100 mg/kg of body weight). PNU-100480 was more active than linezolid, and its efficacy increased with an escalation of the dose. Subsequently, the activity of PNU-100480 alone and in combination with rifampin or isoniazid was evaluated and was compared to that of isoniazid-rifampin. The activity of PNU-100480 was similar to that of isoniazid and/or rifampin in the various combinations tested. Further evaluation of these oxazolidinones in the murine test system would be useful prior to the development of clinical studies with humans. JF - Antimicrobial Agents & Chemotherapy AU - Cynamon, M H AU - Klemens, S P AU - Sharpe, CA AU - Chase, S AD - Department of Medicine, Veteran Affairs Medical Center, 800 Irving Ave., Syracuse, NY 13210, USA, Cynamon.Michael@Syracuse.VA.Gov Y1 - 1999/05// PY - 1999 DA - May 1999 SP - 1189 EP - 1191 VL - 43 IS - 5 SN - 0066-4804, 0066-4804 KW - Eperezolid KW - Linezolid KW - Mice KW - PNU-100480 KW - Microbiology Abstracts B: Bacteriology KW - Antimycobacterial agents KW - Animal models KW - Tuberculosis KW - Mycobacterium tuberculosis KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17253082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Activities+of+several+novel+oxazolidinones+against+Mycobacterium+tuberculosis+in+a+murine+model&rft.au=Cynamon%2C+M+H%3BKlemens%2C+S+P%3BSharpe%2C+CA%3BChase%2C+S&rft.aulast=Cynamon&rft.aufirst=M&rft.date=1999-05-01&rft.volume=43&rft.issue=5&rft.spage=1189&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Antimycobacterial agents; Animal models; Tuberculosis ER - TY - JOUR T1 - Inhibition of PC-3 human androgen-independent prostate cancer and its metastases by cytotoxic somatostatin analogue AN-238. AN - 69702952; 10213505 AB - We evaluated whether AN-238, the cytotoxic analogue of somatostatin (SST) consisting of the radical 2-pyrrolinodoxorubicin (AN-201) linked covalently to the SST octapeptide carrier RC-121 (D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2), could be used for targeting human primary and metastatic prostate carcinomas that express SST receptors (SSTRs). The antitumor activity and toxicity of AN-238 and its components were first characterized in nude mice bearing s.c. xenografts of PC-3 human androgen-independent prostate cancer. In experiment 1, AN-238 was injected once i.v. at 200 nmol/kg when the mean volume of s.c. tumors was about 30 mm3. Administration of AN-238 inhibited tumor growth, as shown by a 74% decrease in tumor volume and by a 71% reduction in tumor weight after 7 weeks as compared with the control group. AN-201 at an equimolar dose did not show any antitumor activity. The mortality was 14.3% (one of seven mice) in the AN-238-treated group and 47% (three of seven mice) in mice that received AN-201. In experiment 2, two i.v. injections of AN-238 at 150 nmol/kg were given 10 days apart when the tumors measured 65-70 mm3. A significant inhibition of tumor volume (62.3%; P < 0.001) and tumor weight (61.1%; P < 0.01) was observed after 4 weeks of treatment. AN-201, given alone at the same dose or coadministered with RC-121, had no significant effect on PC-3 tumors. The suppression of tumor growth induced by AN-238 was accompanied by a significant enhancement of apoptosis (P < 0.01). There were similar side effects in all treated groups, which included a transient loss of body weight and leukopenia. The effectiveness of AN-238 in a metastatic model was then investigated in animals implanted orthotopically with 2 x 10(6) PC-3 cells. Two i.v. injections of AN-238 or AN-201 at 150 nmol/kg were administered 10 days apart at 10 weeks after intraprostatic inoculation of PC-3 cells. After 4 weeks of treatment, the mean weight of primary tumors in animals receiving AN-238 was 77% lower (P < 0.01) than that in controls. This reduction was also significantly greater (P < 0.05) than that in animals given AN-201, which showed only a 34% inhibition (nonsignificant versus controls). All control animals and four of six (67%) mice treated with AN-201 developed metastases in the lymph nodes; however, no lymphatic spread of cancer was found in the AN-238-treated group. Using reverse transcription-PCR analysis, we demonstrated the expression of SSTR2 and SSTR5 in intraprostatic tumors and their metastases in lymph nodes as well as in s.c. tumors. The present study demonstrates the high efficacy of SSTR-targeted chemotherapy in a model of advanced human androgen-independent prostatic carcinoma, as shown by the inhibition of primary tumors and their metastases by the cytotoxic SST analogue AN-238. JF - Cancer research AU - Plonowski, A AU - Schally, A V AU - Nagy, A AU - Sun, B AU - Szepeshazi, K AD - Endocrine, Polypeptide and Cancer Institute, Veterans Administration Medical Center, New Orleans, Louisiana 70112-1262, USA. Y1 - 1999/04/15/ PY - 1999 DA - 1999 Apr 15 SP - 1947 EP - 1953 VL - 59 IS - 8 SN - 0008-5472, 0008-5472 KW - AN 238 KW - 0 KW - Androgens KW - Antibiotics, Antineoplastic KW - Pyrroles KW - Receptors, Somatostatin KW - AN 204 KW - 175795-76-3 KW - Somatostatin KW - 51110-01-1 KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Doxorubicin -- analogs & derivatives KW - Humans KW - Mice KW - Mice, Nude KW - Somatostatin -- analogs & derivatives KW - Pyrroles -- therapeutic use KW - Lymphatic Metastasis -- prevention & control KW - Neoplasm Transplantation KW - Tumor Cells, Cultured KW - Receptors, Somatostatin -- biosynthesis KW - Transplantation, Heterologous KW - Doxorubicin -- therapeutic use KW - Androgens -- metabolism KW - Male KW - Prostatic Neoplasms -- pathology KW - Prostatic Neoplasms -- drug therapy KW - Neoplasm Metastasis -- prevention & control KW - Antibiotics, Antineoplastic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69702952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Inhibition+of+PC-3+human+androgen-independent+prostate+cancer+and+its+metastases+by+cytotoxic+somatostatin+analogue+AN-238.&rft.au=Plonowski%2C+A%3BSchally%2C+A+V%3BNagy%2C+A%3BSun%2C+B%3BSzepeshazi%2C+K&rft.aulast=Plonowski&rft.aufirst=A&rft.date=1999-04-15&rft.volume=59&rft.issue=8&rft.spage=1947&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-06-07 N1 - Date created - 1999-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stimulus length uncertainty with dichotic digit recognition. AN - 85309729; pmid-10941713 AB - Dichotic digit listening was made more difficult by interleaving one-, two-, three-, and four-pair digits within a test list in which the subjects did not know a priori the number of digit pairs presented on a given trial, thereby introducing listener uncertainty. Twenty right-handed (mean age = 26.8 years) and 20 left-handed adults (mean age = 24.0) with normal hearing and 40 right-handed adults in the 60- to 75-years age range (mean age = 67.2) with mild-to-moderate sensorineural hearing loss were evaluated. Compared to traditional paradigms, the uncertainty of stimulus length (one, two, three, or four pairs) reduced overall recognition performance on stimuli presented to both ears of all groups, but the reduction was more pronounced for the left ear than for the right ear. The recognition performance of the right-handed subjects was more homogeneous than the performance of the left-handed subjects. In comparison to the young subjects, the 60- to 75-year-old group had substantially reduced recognition performance. JF - Journal of the American Academy of Audiology AU - Strouse, A AU - Wilson, R H AD - Auditory Research Laboratory, Veteran Affairs Medical Center, Mountain Home, Tennessee 37684, USA. ANNE.STROUSE@MED.VA.GOV Y1 - 1999/04// PY - 1999 DA - April 1999 SP - 219 EP - 229 VL - 10 IS - 4 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Phonetics KW - Adult KW - Aged KW - Middle Aged KW - Time Factors KW - Functional Laterality -- physiology KW - Speech Perception -- physiology KW - Dichotic Listening Tests KW - Hearing Loss, Sensorineural -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85309729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Stimulus+length+uncertainty+with+dichotic+digit+recognition.&rft.au=Strouse%2C+A%3BWilson%2C+R+H&rft.aulast=Strouse&rft.aufirst=A&rft.date=1999-04-01&rft.volume=10&rft.issue=4&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-01-15 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Mechanism of arrhythmogenicity of the short-long cardiac sequence that precedes ventricular tachyarrhythmias in the long QT syndrome. AN - 69672691; 10193747 AB - The purpose of this study was to investigate the electrophysiologic mechanism(s) that underlie the transition of one or more short-long (S-L) cardiac sequences to ventricular tachyarrhythmias (VTs) in the long QT syndrome. One or more S-L cardiac cycles, usually the result of a ventricular bigeminal rhythm, frequently precedes the onset of VT in patients with either normal or prolonged QT interval. Electrophysiologic mechanisms that underlie this relationship have not been fully explained. We investigated electrophysiologic changes associated with the transition of a S-L cardiac sequence to VT in the canine anthopleurin-A model, a surrogate of LQT3. Experiments were performed on 12 mongrel puppies after administration of anthopleurin-A. Correlation of tridimensional activation and repolarization patterns was obtained from up to 384 electrograms. Activation-recovery intervals were measured from unipolar electrograms and were considered to represent local repolarization. We analyzed 24 different episodes of a S-L sequence that preceded VT obtained from 12 experiments. The VT followed one S-L sequence (five episodes), two to five S-L sequences (12 episodes) and more than five S-L sequences (seven episodes). The single premature ventricular beats coupled to the basic beats were consistently due to a subendocardial focal activity (SFA). There were two basic mechanisms for the development of VT after one or more S-L sequences: 1) in 10 examples of a S-L sequence due to a stable unifocal bigeminal rhythm, the occurrence of a second SFA, which arose consistently from a different site, infringed on the pattern of dispersion of repolarization (DR) of the first SFA to initiate reentrant excitation; 2) in the remaining 14 episodes of a S-L sequence, a slight lengthening (50 to 150 ms) in one or more preceding cycle lengths (CLs) resulted in alterations of the spatial pattern of DR at key sites to promote reentry. The lengthening of the preceding CL produced differentially a greater degree of prolongation of repolarization at midmyocardial and endocardial sites compared with epicardial sites with consequent increase of DR. The increased DR at key adjacent sites resulted in the development of de novo zones of functional conduction block and/or slowed conduction to create the necessary prerequisites for successful reentry. The occurrence of VT after one or more S-L cardiac sequences was due to well defined electrophysiologic changes with predictable consequences that promoted reentrant excitation. JF - Journal of the American College of Cardiology AU - El-Sherif, N AU - Caref, E B AU - Chinushi, M AU - Restivo, M AD - Department of Medicine, State University of New York Health Science Center and Veterans Affairs Medical Center, Brooklyn 11203, USA. el-sherif.nabil@brooklyn.va.gov Y1 - 1999/04// PY - 1999 DA - April 1999 SP - 1415 EP - 1423 VL - 33 IS - 5 SN - 0735-1097, 0735-1097 KW - Peptides KW - 0 KW - anthopleurin-A KW - 60880-63-9 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Dogs KW - Disease Models, Animal KW - Follow-Up Studies KW - Image Processing, Computer-Assisted KW - Peptides -- toxicity KW - Tachycardia, Ventricular -- etiology KW - Tachycardia, Ventricular -- physiopathology KW - Long QT Syndrome -- chemically induced KW - Long QT Syndrome -- complications KW - Electrocardiography KW - Long QT Syndrome -- physiopathology KW - Heart Conduction System -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69672691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Mechanism+of+arrhythmogenicity+of+the+short-long+cardiac+sequence+that+precedes+ventricular+tachyarrhythmias+in+the+long+QT+syndrome.&rft.au=El-Sherif%2C+N%3BCaref%2C+E+B%3BChinushi%2C+M%3BRestivo%2C+M&rft.aulast=El-Sherif&rft.aufirst=N&rft.date=1999-04-01&rft.volume=33&rft.issue=5&rft.spage=1415&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-04-19 N1 - Date created - 1999-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The contribution of various NOS gene products to HIV-1 coat protein (gp120)-mediated retinal ganglion cell injury. AN - 69662938; 10102296 AB - There is growing evidence that the neuronal pathology seen with HIV-1 is mediated, at least in part, through an excitotoxic/free radical pathway. Nitric oxide (NO) plays a critical role in the nervous system, in both normal and pathologic states, and appears to be involved in a variety of excitotoxic pathways. Whether isoforms of nitric oxide synthase (NOS) are involved in gp120-mediated neuronal loss in the retina was therefore explored. To determine which (if any) of the various isoforms of NOS are critical in gp120-mediated damage in the retina, neuronal NOS-deficient [nNOS(-/-)], endothelial NOS-deficient [eNOS(-/ -)], and immunologic NOS-deficient [iNOS(-/-)] mice were subjected to intravitreal injections of gp120. Retinal ganglion cells in the nNOS(-/-) mouse were relatively resistant to gp120, manifesting attenuation of gp120-induced injury compared with wild-type mice. The iNOS(-/-) and eNOS(-/-) mice were as susceptible to gp120 toxicity as control animals. NOS inhibitors were protective against this toxicity. The presence of nNOS is a prerequisite for the full expression of gp120-mediated loss in the retina; eNOS and iNOS do not appear to play a significant role. JF - Investigative ophthalmology & visual science AU - Dreyer, E B AU - Zurakowski, D AU - Gorla, M AU - Vorwerk, C K AU - Lipton, S A AD - Department of Ophthalmology, Scheie Eye Institute, Philadelphia Veterans Administration, University of Pennsylvania, USA. Y1 - 1999/04// PY - 1999 DA - April 1999 SP - 983 EP - 989 VL - 40 IS - 5 SN - 0146-0404, 0146-0404 KW - Enzyme Inhibitors KW - 0 KW - HIV Envelope Protein gp120 KW - Nitroarginine KW - 2149-70-4 KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Nitric Oxide Synthase Type I KW - Nitric Oxide Synthase Type II KW - Nitric Oxide Synthase Type III KW - Nos1 protein, mouse KW - Nos2 protein, mouse KW - Nos3 protein, mouse KW - Index Medicus KW - AIDS/HIV KW - Animals KW - Cell Count KW - Mice KW - Cell Death -- drug effects KW - Mice, Knockout KW - Mice, Mutant Strains KW - Nitroarginine -- pharmacology KW - Mice, Inbred C57BL KW - Enzyme Inhibitors -- pharmacology KW - Female KW - Male KW - Retinal Ganglion Cells -- enzymology KW - Nitric Oxide Synthase -- antagonists & inhibitors KW - Nitric Oxide Synthase -- physiology KW - Retinal Ganglion Cells -- drug effects KW - HIV Envelope Protein gp120 -- toxicity KW - Retinal Ganglion Cells -- pathology KW - HIV-1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69662938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=The+contribution+of+various+NOS+gene+products+to+HIV-1+coat+protein+%28gp120%29-mediated+retinal+ganglion+cell+injury.&rft.au=Dreyer%2C+E+B%3BZurakowski%2C+D%3BGorla%2C+M%3BVorwerk%2C+C+K%3BLipton%2C+S+A&rft.aulast=Dreyer&rft.aufirst=E&rft.date=1999-04-01&rft.volume=40&rft.issue=5&rft.spage=983&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-04-02 N1 - Date created - 1999-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Free-living physical activity in COPD: Assessment with accelerometer and activity checklist AN - 20064713; 10059737 AB - To assess physical activity and disability in chronic obstructive pulmonary disease (COPD), we evaluated the use of an accelerometer and checklist to measure free-living physical activity. Seventeen males with stable COPD completed a daily activity checklist for 14 days. Ten subjects concurrently wore an Actiped accelerometer (FitSense, Southborough, Massa-chussetts) that records steps per day. Regression models assessed relationships between steps per day, number of daily checklist activities performed, and clinical measures of COPD status. The average steps per day ranged from 406 to 4,856. The median intrasubject coefficient of variation for steps per day was 0.52 (interquartile range [IQR] 0.41-0.58) and for number of daily checklist activities performed was 0.28 (IQR 0.22-0.32). A higher number of steps per day was associated with a greater distance walked on the 6-minute walk test and better health-related quality of life. A higher number of daily checklist activities performed was associated with a higher force expiratory volume in 1 s percent predicted and lowerbody mass index, airflow obstruction, dyspnea, exercise capacity (BODE) index. Prospectively measuring free-living physical activity in COPD using an unobtrusive accelerometer and simple activity checklist is feasible. Low intrasubject variation was found in free-living physical activity, which is significantly associated with clinical measures of COPD status. JF - Journal of Rehabilitation Research and Development AU - Moy, M L AU - Matthess, K AU - Stolzmann, K AU - Reilly, J AU - Garshick, E AD - VA Boston Healthcare System, Pulmonary and Critical Care Medicine Section, 1400 VFW Parkway, Mail Code 111PI, West Roxbury, MA 02132, USA, marilyn.moy@va.gov Y1 - 1999/04// PY - 1999 DA - Apr 1999 SP - 277 EP - 284 VL - 36 IS - 2 SN - 0748-7711, 0748-7711 KW - Physical Education Index KW - Evaluation KW - Handicapped KW - Chronic diseases KW - Exercise KW - Checklists KW - Lifestyle KW - PE 110:Physical Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20064713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Free-living+physical+activity+in+COPD%3A+Assessment+with+accelerometer+and+activity+checklist&rft.au=Moy%2C+M+L%3BMatthess%2C+K%3BStolzmann%2C+K%3BReilly%2C+J%3BGarshick%2C+E&rft.aulast=Moy&rft.aufirst=M&rft.date=1999-04-01&rft.volume=36&rft.issue=2&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2008.07.0083 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Evaluation; Handicapped; Chronic diseases; Exercise; Checklists; Lifestyle DO - http://dx.doi.org/10.1682/JRRD.2008.07.0083 ER - TY - JOUR T1 - Adult Pneumococcal Cellulitis: Case Report and Review AN - 17368845; 4572384 AB - Streptococcus pneumoniae is an infrequent cause of skin infections in adults. Prior reports describe facial cellulitis in children with hypogammaglobulinemia and hemoglobinopathy and in adults with connective tissue disorders. We report a case of pneumococcal cellulitis and bacteremia in an alcoholic patient with diabetes and discuss this disease in adult patients. JF - Clinical Infectious Diseases AU - Parada, J P AU - Maslow, J N AD - VA Medical Center (151), 150 South Huntington Avenue, Boston, Massachusetts 02130, USA, maslow.joel_n.md@boston.va.gov Y1 - 1999/04// PY - 1999 DA - Apr 1999 SP - 918 VL - 28 IS - 4 SN - 1058-4838, 1058-4838 KW - man KW - Microbiology Abstracts B: Bacteriology KW - Diabetes mellitus KW - Cellulitis KW - Streptococcus pneumoniae KW - Reviews KW - Bacteremia KW - Alcoholics KW - J 02843:Skin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17368845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Adult+Pneumococcal+Cellulitis%3A+Case+Report+and+Review&rft.au=Parada%2C+J+P%3BMaslow%2C+J+N&rft.aulast=Parada&rft.aufirst=J&rft.date=1999-04-01&rft.volume=28&rft.issue=4&rft.spage=918&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pneumoniae; Bacteremia; Alcoholics; Diabetes mellitus; Cellulitis; Reviews ER - TY - JOUR T1 - Decreased accumulation of endogenous brain-derived neurotrophic factor against constricting sciatic nerve ligatures in streptozotocin-diabetic and galactose-fed rats. AN - 69701891; 10213157 AB - Anterograde and retrograde trafficking of brain-derived neurotrophic factor (BDNF) was examined in streptozotocin-diabetic and galactose-fed rats by measuring accumulation of endogenous neurotrophin proximal and distal to two constricting sciatic nerve ligatures and by direct injection of radiolabeled neurotrophin into the sciatic nerve. Compared to controls, accumulation of endogenous BDNF proximal and distal to the ligatures as well as basal levels in non-ligated nerve segments were decreased in streptozotocin-diabetic and galactose-fed rats. Neither streptozotocin diabetes nor galactose intoxication affected the amount of 125I-labeled BDNF retrogradely transported to the DRG after injection into the sciatic nerve. These results suggest that reduced anterograde and retrograde accumulations of BDNF in experimental diabetes are not a result of impaired capacity for receptor-mediated transport. JF - Neuroscience letters AU - Mizisin, A P AU - DiStefano, P S AU - Liu, X AU - Garrett, D N AU - Tonra, J R AD - Department of Pathology, University of California, San Diego, The Veterans Administration Medical Center, La Jolla, USA. amizisin@ucsd.edu Y1 - 1999/03/26/ PY - 1999 DA - 1999 Mar 26 SP - 149 EP - 152 VL - 263 IS - 2-3 SN - 0304-3940, 0304-3940 KW - Brain-Derived Neurotrophic Factor KW - 0 KW - Iodine Radioisotopes KW - Galactose KW - X2RN3Q8DNE KW - Index Medicus KW - Rats KW - Animals KW - Reference Values KW - Rats, Sprague-Dawley KW - Female KW - Axonal Transport KW - Ganglia, Spinal -- physiopathology KW - Brain-Derived Neurotrophic Factor -- metabolism KW - Ganglia, Spinal -- pathology KW - Ganglia, Spinal -- metabolism KW - Sciatic Nerve -- metabolism KW - Diabetes Mellitus, Experimental -- metabolism KW - Galactose -- toxicity KW - Sciatic Nerve -- pathology KW - Sciatic Nerve -- physiopathology KW - Diabetes Mellitus, Experimental -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69701891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Decreased+accumulation+of+endogenous+brain-derived+neurotrophic+factor+against+constricting+sciatic+nerve+ligatures+in+streptozotocin-diabetic+and+galactose-fed+rats.&rft.au=Mizisin%2C+A+P%3BDiStefano%2C+P+S%3BLiu%2C+X%3BGarrett%2C+D+N%3BTonra%2C+J+R&rft.aulast=Mizisin&rft.aufirst=A&rft.date=1999-03-26&rft.volume=263&rft.issue=2-3&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-06-10 N1 - Date created - 1999-06-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aging and cancer of the stomach and colon. AN - 69630341; 10077539 AB - Although the incidence of most human malignancies including cancer of the gastrointestinal tract increases dramatically with advancing age, the precise role of aging in that increase remains a matter of continued controversy. Many probable explanations for the age-related rise in cancer incidence have been offered including altered carcinogen metabolism and the cumulative effects of protracted exposure to cancer-causing agents. Neoplasia of the stomach or colon is a multi-stage process with hyperproliferation being central to the initiation of carcinogenesis. Since aging is associated with increased gastrointestinal mucosal cell proliferation, the possibility that aging itself may render target cells more susceptible to carcinogenic transformation continues to be an area of intense interest and study. This review will examine the evidence for age-related alterations in the structural and functional properties of the gastric and colonic mucosa in an effort to further elucidate the potential mechanisms of carcinogenesis which may be involved during the aging process. JF - Frontiers in bioscience : a journal and virtual library AU - Jaszewski, R AU - Ehrinpreis, M N AU - Majumdar, A P AD - John D. Dingell, Department of Internal Medicine, VA Medical Center, 4646 John R, Detroit, MI 48201, USA. jaszewski.richard@allen-park.va.gov Y1 - 1999/03/15/ PY - 1999 DA - 1999 Mar 15 SP - D322 EP - D328 VL - 4 SN - 1093-9946, 1093-9946 KW - Index Medicus KW - Stomach Neoplasms -- pathology KW - Colonic Neoplasms -- physiopathology KW - Stomach Diseases -- pathology KW - Humans KW - Colonic Diseases -- pathology KW - Colonic Diseases -- physiopathology KW - Stomach Neoplasms -- physiopathology KW - Stomach Diseases -- physiopathology KW - Colonic Neoplasms -- pathology KW - Cell Division KW - Intestinal Mucosa -- physiology KW - Aging -- physiology KW - Gastric Mucosa -- anatomy & histology KW - Gastric Mucosa -- physiology KW - Aging -- pathology KW - Intestinal Mucosa -- anatomy & histology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69630341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+bioscience+%3A+a+journal+and+virtual+library&rft.atitle=Aging+and+cancer+of+the+stomach+and+colon.&rft.au=Jaszewski%2C+R%3BEhrinpreis%2C+M+N%3BMajumdar%2C+A+P&rft.aulast=Jaszewski&rft.aufirst=R&rft.date=1999-03-15&rft.volume=4&rft.issue=&rft.spage=D322&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+bioscience+%3A+a+journal+and+virtual+library&rft.issn=10939946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-03-24 N1 - Date created - 1999-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polyps as biomarkers for colorectal neoplasia. AN - 69627464; 10077546 AB - Current understanding of colorectal carcinogenesis suggests a series of genetic changes occurring pari passu with morphological changes ultimately resulting in a cancerous lesion. The adenomatous polyp was originally the prototype of the preneoplastic lesion but recently, other colonic polyps, primarily the hamartomas, have been clinically characterized as colorectal cancer biomarkers with genetic changes found mainly in the mesenchymal component as opposed to the ectodermal, or epithelial element. This, with the current interest in angiogenesis playing a role in the propagation of neoplastic lesions, has now encompassed every tissue element and opened the way for an understanding of the oncogenic process. This has suggested that considerable interaction occurs between all tissue elements, including what was previously described as epithelial-matrix interactions. While hyperplastic polyps are thought not to confer risk for cancer, they may offer clues as to the first steps of the overall process. Microadenomas have introduced new clinical as well as biological considerations, as unique risk factors. Investigation of these lesions has moved from purely morphological correlations to mechanistic dissections of important biological pathways using both genetic and protein chemistry tools. This review explores the microcosm of the colonic polyp and its relation to cancer as the quintessential premalignant biomarker. JF - Frontiers in bioscience : a journal and virtual library AU - Tobi, M AD - John D. Dingell Veterans Administration Medical Center, and Wayne State University School of Medicine, Detroit, MI 48201, USA. tobim@allen-park.va.gov Y1 - 1999/03/15/ PY - 1999 DA - 1999 Mar 15 SP - D329 EP - D338 VL - 4 SN - 1093-9946, 1093-9946 KW - Antibodies, Monoclonal KW - 0 KW - Biomarkers, Tumor KW - Index Medicus KW - Adenomatous Polyposis Coli -- pathology KW - Hyperplasia KW - Hamartoma -- pathology KW - Adenomatous Polyposis Coli -- genetics KW - Apoptosis KW - Peutz-Jeghers Syndrome -- pathology KW - Peutz-Jeghers Syndrome -- genetics KW - Humans KW - Adult KW - Adenoma -- immunology KW - Child KW - Adenoma -- pathology KW - Precancerous Conditions -- genetics KW - Colorectal Neoplasms -- pathology KW - Intestinal Polyps -- immunology KW - Intestinal Polyps -- pathology KW - Colorectal Neoplasms -- genetics KW - Precancerous Conditions -- immunology KW - Intestinal Polyps -- genetics KW - Precancerous Conditions -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69627464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+bioscience+%3A+a+journal+and+virtual+library&rft.atitle=Polyps+as+biomarkers+for+colorectal+neoplasia.&rft.au=Tobi%2C+M&rft.aulast=Tobi&rft.aufirst=M&rft.date=1999-03-15&rft.volume=4&rft.issue=&rft.spage=D329&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+bioscience+%3A+a+journal+and+virtual+library&rft.issn=10939946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-03-24 N1 - Date created - 1999-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Morphine synergizes with lipopolysaccharide in a chronic endotoxemia model. AN - 69732486; 10229120 AB - Emergent or elective surgical procedures may be complicated by sepsis, resulting in critical illness that can lead to organ failure and death. The opioid drug, morphine is widely used to alleviate pain in post-surgical patients; however, it is well documented that chronic treatment of mice with morphine affects the proliferation, differentiation and function of immune cells. Thus, morphine might be expected to exacerbate the effects of sepsis, which also compromises the immune system. To test this notion, we investigated the effect on several immune functions of a clinical dose of morphine (4 mg/kg) superimposed upon a lipopolysaccharide (LPS)-induced infection model. Our results show that this relatively low dose of morphine, though generally having no effects on immune parameters by itself, significantly augmented LPS responses. A clinical dose of morphine (4 mg/kg body weight) superimposed upon an animal model of sepsis resulted in a significant increase in mortality at 48 h. In the absence of the drug, most septic animals died after 96 h. Phenotypic responses such as, decreased thymic cellularity, compromised mitogenic response and inhibition of IL-2 synthesis that are evident at 48-72 h after LPS injection appear as early as 24 h in animals that receive morphine in addition to LPS. In addition, our results show that in T cells there is a shift from TH1 type cytokine elaboration to a TH2 type cytokine elaboration in animals that receive both LPS and morphine. JF - Journal of neuroimmunology AU - Roy, S AU - Charboneau, R G AU - Barke, R A AD - Department of Pharmacology, Veterans Administration Medical Center and University of Minnesota, Minneapolis 55417, USA. royxx002@gold.tc.umn.edu Y1 - 1999/03/01/ PY - 1999 DA - 1999 Mar 01 SP - 107 EP - 114 VL - 95 IS - 1-2 SN - 0165-5728, 0165-5728 KW - Interleukin-1 KW - 0 KW - Interleukin-2 KW - Interleukin-6 KW - Lipopolysaccharides KW - Narcotics KW - RNA, Messenger KW - Tumor Necrosis Factor-alpha KW - Interleukin-12 KW - 187348-17-0 KW - Interleukin-4 KW - 207137-56-2 KW - Morphine KW - 76I7G6D29C KW - Interferon-gamma KW - 82115-62-6 KW - Index Medicus KW - AIDS/HIV KW - Animals KW - Interleukin-1 -- immunology KW - Tumor Necrosis Factor-alpha -- immunology KW - Pituitary Gland -- chemistry KW - Disease Models, Animal KW - Interferon-gamma -- immunology KW - Macrophages, Peritoneal -- immunology KW - Organ Size KW - Gene Expression -- immunology KW - Interleukin-4 -- analysis KW - Interleukin-6 -- genetics KW - Tumor Necrosis Factor-alpha -- analysis KW - Th2 Cells -- drug effects KW - Enzyme-Linked Immunosorbent Assay KW - Interleukin-6 -- immunology KW - Interleukin-1 -- genetics KW - Pituitary Gland -- immunology KW - Drug Synergism KW - Th2 Cells -- immunology KW - Interferon-gamma -- analysis KW - Interleukin-6 -- analysis KW - Interleukin-12 -- immunology KW - Thymus Gland -- cytology KW - Th1 Cells -- immunology KW - Macrophages, Peritoneal -- cytology KW - Mice, Inbred ICR KW - Interleukin-4 -- immunology KW - RNA, Messenger -- analysis KW - Mice KW - Thymus Gland -- immunology KW - Interleukin-12 -- analysis KW - Interleukin-2 -- analysis KW - Th1 Cells -- drug effects KW - Chronic Disease KW - Interleukin-2 -- immunology KW - Immunophenotyping KW - Endotoxemia -- chemically induced KW - Endotoxemia -- mortality KW - Lipopolysaccharides -- pharmacology KW - Narcotics -- pharmacology KW - Morphine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69732486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroimmunology&rft.atitle=Morphine+synergizes+with+lipopolysaccharide+in+a+chronic+endotoxemia+model.&rft.au=Roy%2C+S%3BCharboneau%2C+R+G%3BBarke%2C+R+A&rft.aulast=Roy&rft.aufirst=S&rft.date=1999-03-01&rft.volume=95&rft.issue=1-2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroimmunology&rft.issn=01655728&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-05-17 N1 - Date created - 1999-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thyroidectomy for the treatment of Graves' disease. AN - 69707176; 10211602 JF - Thyroid : official journal of the American Thyroid Association AU - Duh, Q Y AD - Department of Surgery, University of California, San Francisco, Surgical Service, VA Medical Center, 94121, USA. Quan-Yang.Duh@MED.VA.GOV Y1 - 1999/03// PY - 1999 DA - March 1999 SP - 259 EP - 261 VL - 9 IS - 3 SN - 1050-7256, 1050-7256 KW - Iodine Radioisotopes KW - 0 KW - Index Medicus KW - Iodine Radioisotopes -- therapeutic use KW - Thyroid Gland -- physiology KW - Thyroid Gland -- surgery KW - Humans KW - Iodine Radioisotopes -- adverse effects KW - Goiter -- surgery KW - Thyroidectomy -- utilization KW - Graves Disease -- radiotherapy KW - Thyroidectomy -- methods KW - Graves Disease -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69707176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thyroid+%3A+official+journal+of+the+American+Thyroid+Association&rft.atitle=Thyroidectomy+for+the+treatment+of+Graves%27+disease.&rft.au=Duh%2C+Q+Y&rft.aulast=Duh&rft.aufirst=Q&rft.date=1999-03-01&rft.volume=9&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Thyroid+%3A+official+journal+of+the+American+Thyroid+Association&rft.issn=10507256&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-07-12 N1 - Date created - 1999-07-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Thyroid. 1999 Mar;9(3):253-7 [10211601] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Radiation safety for health care workers in the bronchoscopy suite. AN - 69694934; 10205715 AB - Increased use of fluoroscopy during flexible bronchoscopy has raised concerns about radiation safety of health care workers in the bronchoscopy suite. We review the potential health risks associated with occupational radiation exposure, the monitoring devices available, and discuss the measures to reduce radiation exposure during flexible bronchoscopy. JF - Clinics in chest medicine AU - Jain, P AU - Fleming, P AU - Mehta, A C AD - Department of Medicine, Louis A. Johnson Veterans Administration Medical Center, Clarksburg, West Virginia, USA. Y1 - 1999/03// PY - 1999 DA - March 1999 SP - 33 EP - 8, ix-x VL - 20 IS - 1 SN - 0272-5231, 0272-5231 KW - Index Medicus KW - Occupational Exposure -- prevention & control KW - Radiation Monitoring -- methods KW - Radiation Injuries -- prevention & control KW - Humans KW - Safety KW - Respiratory Therapy Department, Hospital KW - Fluoroscopy -- adverse effects KW - Radiation Injuries -- etiology KW - Radiation Protection -- methods KW - Bronchoscopy KW - Health Personnel UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69694934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+chest+medicine&rft.atitle=Radiation+safety+for+health+care+workers+in+the+bronchoscopy+suite.&rft.au=Jain%2C+P%3BFleming%2C+P%3BMehta%2C+A+C&rft.aulast=Jain&rft.aufirst=P&rft.date=1999-03-01&rft.volume=20&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Clinics+in+chest+medicine&rft.issn=02725231&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-06-07 N1 - Date created - 1999-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tardive dyskinesia and atypical antipsychotic drugs. AN - 69669585; 10190226 AB - Typical antipsychotic agents produce central nervous system effects, especially extrapyramidal symptoms (EPS) and tardive dyskinesia (TD). Nearly every patient who receives neuroleptic therapy has one or more identifiable risk factors for TD, among the most significant of which are older age, female gender, presence of EPS, diabetes mellitus, affective disorders, and certain parameters of neuroleptic exposure (i.e. dose and duration of therapy). The typical course of TD is a gradual onset after several years of drug therapy, followed by slow improvement or remission, but a large number of patients have persistent TD with irreversible symptoms. In the management of TD, the patient's mental status is of primary concern. Currently, no uniformly safe and effective therapies for TD exist, though a variety of therapeutic agents, including some of the atypical neuroleptics, have been reported to treat TD successfully in some patients. Because TD liability is so much lower with novel antipsychotic therapy, all patients who have TD or are at risk for TD, as well as EPS, should be considered candidates for switching to these new drugs. JF - Schizophrenia research AU - Casey, D E AD - Mental Health Division, Veterans Affairs Medical Center, Portland, OR 97207, USA. daniel.casey@med.VA.gov Y1 - 1999/03/01/ PY - 1999 DA - 1999 Mar 01 SP - S61 EP - S66 VL - 35 Suppl SN - 0920-9964, 0920-9964 KW - Antipsychotic Agents KW - 0 KW - Benzodiazepines KW - 12794-10-4 KW - Pirenzepine KW - 3G0285N20N KW - Clozapine KW - J60AR2IKIC KW - Risperidone KW - L6UH7ZF8HC KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - Age Factors KW - Sex Factors KW - Humans KW - Pirenzepine -- analogs & derivatives KW - Aged KW - Clozapine -- adverse effects KW - Adult KW - Schizophrenia -- drug therapy KW - Middle Aged KW - Risperidone -- adverse effects KW - Female KW - Male KW - Pirenzepine -- adverse effects KW - Basal Ganglia Diseases -- chemically induced KW - Dyskinesia, Drug-Induced -- diagnosis KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69669585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+research&rft.atitle=Tardive+dyskinesia+and+atypical+antipsychotic+drugs.&rft.au=Casey%2C+D+E&rft.aulast=Casey&rft.aufirst=D&rft.date=1999-03-01&rft.volume=35+Suppl&rft.issue=&rft.spage=S61&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+research&rft.issn=09209964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-07-21 N1 - Date created - 1999-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Associations of smoking with hospital-based care and quality of life in patients with obstructive airway disease. AN - 69630230; 10084477 AB - To investigate the relationship between direct or environmental tobacco smoke (ETS) exposure and both hospital-based care (HBC) and quality of life (QOL) among subjects with asthma. We report baseline cross-sectional data on 619 subjects with asthma, including direct or ETS exposure and QOL, and prospective longitudinal data on HBC using administrative databases for 30 months following baseline evaluation. Participants were health maintenance organization members with physician-diagnosed asthma involved in a longitudinal study of risk factors for hospital-based asthma care. Demographic characteristics and QOL were assessed with administered questionnaires, including the Marks Asthma Quality-of-Life (AQLQ) and SF-36 questionnaires. HBC was defined as episodes per person-year of hospital-based asthma care, which included emergency department and urgency care visits, and hospitalizations for asthma. Current smokers reported significantly worse QOL than never-smokers in two of five domains of the AQLQ (p < 0.05). Subjects with ETS exposure also reported significantly worse QOL than those without ETS exposure in two domains (p < 0.05). On the SF-36, current smokers reported significantly worse QOL than never-smokers in five of nine domains (p < 0.05). Subjects with ETS exposure reported significantly worse QOL than those without ETS exposure in three domains (p < 0.05). Current smokers used significantly more hospital-based asthma care than never-smokers (adjusted relative risk [RR], 1.40; 95% confidence interval [CI], 1.01 to 1.95) while ex-smokers did not exhibit increased risk compared with nonsmokers (adjusted RR, 0.94; 95% CI, 0.7 to 1.3). Also, subjects with ETS exposure used significantly more hospital-based asthma care than those without ETS exposure (RR, 2.34; 95% CI, 1.80 to 3.05). Direct or environmental tobacco exposure prospectively predicted increased health-care utilization for asthma and reduced QOL in patients with asthma. These findings add to our existing knowledge of the detrimental effects of tobacco smoke and are of relevance specifically to patients with asthma. JF - Chest AU - Sippel, J M AU - Pedula, K L AU - Vollmer, W M AU - Buist, A S AU - Osborne, M L AD - Division of Pulmonary and Critical Care Medicine, Portland Veterans Administration Medical Center, OR 97207, USA. Y1 - 1999/03// PY - 1999 DA - March 1999 SP - 691 EP - 696 VL - 115 IS - 3 SN - 0012-3692, 0012-3692 KW - Tobacco Smoke Pollution KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Oregon KW - Cross-Sectional Studies KW - Prospective Studies KW - Health Maintenance Organizations KW - Humans KW - Adult KW - Data Interpretation, Statistical KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Smoking KW - Quality of Life KW - Asthma KW - Hospitals -- utilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69630230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Associations+of+smoking+with+hospital-based+care+and+quality+of+life+in+patients+with+obstructive+airway+disease.&rft.au=Sippel%2C+J+M%3BPedula%2C+K+L%3BVollmer%2C+W+M%3BBuist%2C+A+S%3BOsborne%2C+M+L&rft.aulast=Sippel&rft.aufirst=J&rft.date=1999-03-01&rft.volume=115&rft.issue=3&rft.spage=691&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-04-14 N1 - Date created - 1999-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Baboon syndrome from i.v. aminophylline in a patient allergic to ethylenediamine. AN - 69615861; 10073456 JF - Contact dermatitis AU - Guin, J D AU - Fields, P AU - Thomas, K L AD - John L. McClellan Veterans Administration Hospital, Little Rock, Arkansas 72205, USA. Y1 - 1999/03// PY - 1999 DA - March 1999 SP - 170 EP - 171 VL - 40 IS - 3 SN - 0105-1873, 0105-1873 KW - Allergens KW - 0 KW - Ethylenediamines KW - Aminophylline KW - 27Y3KJK423 KW - ethylenediamine KW - 60V9STC53F KW - Index Medicus KW - Diagnosis, Differential KW - Injections, Intravenous KW - Syndrome KW - Humans KW - Aged KW - Male KW - Ethylenediamines -- adverse effects KW - Drug Eruptions -- etiology KW - Dermatitis, Allergic Contact -- etiology KW - Anus Diseases -- diagnosis KW - Dermatitis, Allergic Contact -- diagnosis KW - Anus Diseases -- etiology KW - Allergens -- adverse effects KW - Aminophylline -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69615861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contact+dermatitis&rft.atitle=Baboon+syndrome+from+i.v.+aminophylline+in+a+patient+allergic+to+ethylenediamine.&rft.au=Guin%2C+J+D%3BFields%2C+P%3BThomas%2C+K+L&rft.aulast=Guin&rft.aufirst=J&rft.date=1999-03-01&rft.volume=40&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Contact+dermatitis&rft.issn=01051873&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-06-23 N1 - Date created - 1999-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pilocarpine toxicity in retinal ganglion cells. AN - 69610359; 10067991 AB - Muscarinic agents reduce intraocular pressure by enhancing aqueous outflow, probably by stimulating ciliary muscle contraction. However, pilocarpine is a well characterized neurotoxin and is widely used to generate animal seizure models. It was therefore investigated whether pilocarpine was also toxic to retinal ganglion cells. Dissociated whole retinal preparations were prepared from postnatal day 16 to 19 rats. Retinal ganglion cells had been previously back-labeled with a fluorescent tracer. Retinal cells were incubated with pilocarpine, lithium, and inositol derivatives, and viability of the retrogradely labeled retinal ganglion cells was assayed after 24 hours. Pilocarpine was toxic to retinal ganglion cells in a dose-dependent fashion. This toxicity was potentiated by lithium and blocked by epi- and myo-inositol. Pilocarpine is toxic to retinal ganglion cells in a mixed culture assay. This toxicity appears to depend on the inositol pathway and is similar to its mode of action in other neurons. However, 0.4 mM pilocarpine (the lowest concentration that did not affect ganglion cell survival) is roughly 1000-fold higher than the vitreal concentration and 20-fold higher than the scleral concentration that can be obtained with topical administration of 2% pilocarpine in the rabbit eye. JF - Investigative ophthalmology & visual science AU - Vorwerk, C K AU - Simon, P AU - Gorla, M AU - Katowitz, W AU - Zurakowski, D AU - Levin, L A AU - Dreyer, E B AD - The Department of Ophthalmology, Veterans Administration, and the University of Pennsylvania, Philadelphia 19104, USA. Y1 - 1999/03// PY - 1999 DA - March 1999 SP - 813 EP - 816 VL - 40 IS - 3 SN - 0146-0404, 0146-0404 KW - Pilocarpine KW - 01MI4Q9DI3 KW - Inositol KW - 4L6452S749 KW - Lithium KW - 9FN79X2M3F KW - Index Medicus KW - Rats KW - Animals KW - Rats, Long-Evans KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Inositol -- pharmacology KW - Drug Synergism KW - Lithium -- pharmacology KW - Retinal Ganglion Cells -- drug effects KW - Pilocarpine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69610359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Pilocarpine+toxicity+in+retinal+ganglion+cells.&rft.au=Vorwerk%2C+C+K%3BSimon%2C+P%3BGorla%2C+M%3BKatowitz%2C+W%3BZurakowski%2C+D%3BLevin%2C+L+A%3BDreyer%2C+E+B&rft.aulast=Vorwerk&rft.aufirst=C&rft.date=1999-03-01&rft.volume=40&rft.issue=3&rft.spage=813&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-03-10 N1 - Date created - 1999-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mild hypothermia modifies ammonia-induced brain edema in rats after portacaval anastomosis. AN - 69596882; 10029628 AB - The pathogenesis of brain edema in fulminant hepatic failure is still unresolved. Mild hypothermia (33 degrees-35 degreesC) can ameliorate brain edema after traumatic brain injury. We evaluated mild hypothermia in a model of ammonia-induced brain edema in which accumulation of brain glutamine has been proposed as a key pathogenic factor. After portacaval anastomosis, anesthetized rats were infused with ammonium acetate at 33 degrees, 35 degrees, and 37 degreesC or vehicle at 37 degreesC. Water and glutamine levels in the brain, cardiac output, and regional and cerebral hemodynamics were measured when intracranial pressure increased 3-4-fold (ammonia infusion at 37 degrees) and matched times (other groups). Mild hypothermia reduced ammonia-induced brain swelling and increased intracranial pressure. Brain glutamine level was not decreased by hypothermia. Brain edema was accompanied by a specific increase in cerebral blood flow and oxygen consumption, which were normal in both hypothermic groups. When the ammonia infusion was continued in hypothermic rats, plasma ammonia levels continued to increase and brain swelling eventually developed. Mild hypothermia delays ammonia-induced brain edema. In this model, an increase in cerebral perfusion is required for brain edema to become manifest. Mild hypothermia could be tested for treatment of intracranial hypertension in fulminant hepatic failure. JF - Gastroenterology AU - Córdoba, J AU - Crespin, J AU - Gottstein, J AU - Blei, A T AD - Department of Medicine, Veterans Administration Lakeside Medical Center and Northwestern University, Chicago, Illinois, USA. Y1 - 1999/03// PY - 1999 DA - March 1999 SP - 686 EP - 693 VL - 116 IS - 3 SN - 0016-5085, 0016-5085 KW - Acetates KW - 0 KW - Glutamine KW - 0RH81L854J KW - Ammonia KW - 7664-41-7 KW - ammonium acetate KW - RRE756S6Q2 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Intracranial Pressure KW - Cardiac Output KW - Glutamine -- metabolism KW - Intracranial Hypertension -- chemically induced KW - Body Water -- metabolism KW - Cerebrovascular Circulation KW - Rats KW - Rats, Sprague-Dawley KW - Oxygen Consumption KW - Intracranial Hypertension -- therapy KW - Acetates -- toxicity KW - Male KW - Portacaval Shunt, Surgical KW - Brain -- physiopathology KW - Brain Edema -- therapy KW - Brain Edema -- physiopathology KW - Brain Edema -- chemically induced KW - Brain -- drug effects KW - Ammonia -- toxicity KW - Brain -- metabolism KW - Hypothermia, Induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69596882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Mild+hypothermia+modifies+ammonia-induced+brain+edema+in+rats+after+portacaval+anastomosis.&rft.au=C%C3%B3rdoba%2C+J%3BCrespin%2C+J%3BGottstein%2C+J%3BBlei%2C+A+T&rft.aulast=C%C3%B3rdoba&rft.aufirst=J&rft.date=1999-03-01&rft.volume=116&rft.issue=3&rft.spage=686&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-03-22 N1 - Date created - 1999-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pertussis toxin-induced lung edema. Role of manganese superoxide dismutase and protein kinase C. AN - 69593681; 10030845 AB - The mechanism by which pertussis toxin (Ptx) causes lung edema is not clear. We investigated the role of pulmonary manganese superoxide dismutase (MnSOD) and protein kinase C (PKC) in Ptx-induced lung edema. We demonstrated that intraperitoneal injection of Ptx at a concentration of 5 microg/100 g body weight caused a similar degree of lung edema in 2 d, as measured by lung wet weight/dry weight ratio, in heterozygous MnSOD gene (Sod2)-knockout mice (Sod2(+/-)) and in their wild-type littermates (Sod2(+/+)). The level of lung MnSOD activity in Sod2(+/-) mice was approximately half that of Sod2(+/-) mice. Ptx had no effect on levels of lung MnSOD messenger RNA, immunoreactive protein, or enzyme activity in either Sod2(+/+) or Sod2(+/-) mice. Ptx also had no effect on lung copper-zinc SOD, catalase, and glutathione peroxidase activities in these mice. On the other hand, Ptx caused the activation of lung PKC, for example, by translocation of a 72-kD PKC isoform from the cytosolic fraction to the membrane fraction. Pretreatment of mice with bisindolylmaleimide, a PKC inhibitor, prevented both the Ptx-induced activation of PKC and lung edema. These data suggest that Ptx-induced lung edema in mice is, at least in part, due to the activation of lung PKC. JF - American journal of respiratory cell and molecular biology AU - Tsan, M F AU - Cao, X AU - White, J E AU - Sacco, J AU - Lee, C Y AD - Research, Medical, and Laboratory Services, Samuel S. Stratton Department of Veterans Affairs Medical Center, Albany, New York 12208, USA. tsan.min-fu@albany.va.gov Y1 - 1999/03// PY - 1999 DA - March 1999 SP - 465 EP - 473 VL - 20 IS - 3 SN - 1044-1549, 1044-1549 KW - Antioxidants KW - 0 KW - Isoenzymes KW - RNA, Messenger KW - Virulence Factors, Bordetella KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Pertussis Toxin KW - EC 2.4.2.31 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Index Medicus KW - Animals KW - Enzyme Activation KW - RNA, Messenger -- analysis KW - Biological Transport KW - Mice KW - Isoenzymes -- metabolism KW - Mice, Knockout KW - Protein Kinase C -- metabolism KW - Virulence Factors, Bordetella -- pharmacology KW - Pulmonary Edema -- chemically induced KW - Superoxide Dismutase -- metabolism KW - Superoxide Dismutase -- genetics KW - Pulmonary Edema -- etiology KW - Pulmonary Edema -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69593681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Pertussis+toxin-induced+lung+edema.+Role+of+manganese+superoxide+dismutase+and+protein+kinase+C.&rft.au=Tsan%2C+M+F%3BCao%2C+X%3BWhite%2C+J+E%3BSacco%2C+J%3BLee%2C+C+Y&rft.aulast=Tsan&rft.aufirst=M&rft.date=1999-03-01&rft.volume=20&rft.issue=3&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-04-02 N1 - Date created - 1999-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Substance abuse and sexual trauma in a female veteran population. AN - 69587033; 10023609 AB - An increasing number of researchers have explored connections between substance abuse, posttraumatic stress disorder (PTSD), and sexual assault histories in civilian women. Despite literature suggesting the prevalence of substance abuse and sexual assault for female veterans, few studies have investigated these variables in a female veteran population. Thus, this paper was designed to provide preliminary information about this group of women. The results of this preliminary study suggest a high incidence of PTSD related to sexual trauma in a substance-abusing population of female veterans and a high incidence of substance abuse among female veterans who presented requesting help for sexual trauma. Suggestions for future study include examination of comparison samples of female veterans with and without PTSD and substance abuse across a variety of dimensions, including psychiatric symptoms, substance use, treatment utilization, and impact of treatment. Implications for assessment are highlighted. JF - Journal of substance abuse treatment AU - Davis, T M AU - Wood, P S AD - Veterans' Administration Puget Sound Health Care System, Seattle Division, WA, USA. Y1 - 1999/03// PY - 1999 DA - March 1999 SP - 123 EP - 127 VL - 16 IS - 2 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Sex Factors KW - Humans KW - Patient Acceptance of Health Care -- statistics & numerical data KW - Health Surveys KW - Adult KW - Incidence KW - Middle Aged KW - Military Psychiatry KW - United States -- epidemiology KW - Female KW - Comorbidity KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Sex Offenses -- psychology KW - Sexual Harassment -- psychology KW - Sex Offenses -- statistics & numerical data KW - Veterans -- statistics & numerical data KW - Stress Disorders, Post-Traumatic -- psychology KW - Sexual Harassment -- statistics & numerical data KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69587033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Substance+abuse+and+sexual+trauma+in+a+female+veteran+population.&rft.au=Davis%2C+T+M%3BWood%2C+P+S&rft.aulast=Davis&rft.aufirst=T&rft.date=1999-03-01&rft.volume=16&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-04-07 N1 - Date created - 1999-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In utero gene therapy: The case against AN - 17194999; 4488148 AB - Responsible scientists should resist the application of powerful genetic tools that will tamper with the human germline. This is, of course, an inevitable result if disease and disability are defined as existing in genomes, therapy is aimed at earlier and earlier stages of development, and the genetic tools used do not allow highly specific targeting to avoid germ and pluripotent cells. It would be a tragedy if once again the Siren of reductionism blinded well-meaning interventionists, allowing the use of inadequately refined genetic methods to modify highly evolved and interactive human systems. The newly created heritable forms of pain and suffering that might arise would be an ironic legacy for the gene therapy `wild-catters'. Human disease and illness is always complex and multifactorial. Biologically derived variability, modified and commingled with environmental factors (including psychological, social, political and cultural modifiers), creates phenotypic heterogeneity within disease nosology systems and confounds measurement and applications of `cures'. When gene therapy is considered for conditions in which mutations at a single locus are associated with significant risk, several questions should be posed. Are there pathological states at the suborganismal level (involving tissues, organs, cells or developmental fields, for example) that may precede clinical detection and be irreversibly affected? Is mutant gene expression temporal, pathological in or on all cell types, affected by developmental stage, or modified by biological or non-biological factors? Is the genetic risk factor (mutation) stable or does it sometimes spontaneously remit? These and other queries should be answered for each mutation considered for intervention. Otherwise, bland discussion of problems of genotype/phenotype correlations will fail to capture the sublimely interesting and important phenomena that underlie the variation within human phenotypic classifications. These issues are only intensified for polygenic disorders. JF - Nature Medicine AU - Billings, PR AD - Council for Responsible Genetics, 5 Upland Road, Cambridge, MA 02140, USA, Paul.billings@med.va.gov Y1 - 1999/03// PY - 1999 DA - Mar 1999 SP - 255 EP - 256 VL - 5 IS - 3 SN - 1078-8956, 1078-8956 KW - man KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Uterus KW - Gene therapy KW - Germ cells KW - Ethics KW - Reviews KW - G 07443:Gene therapy KW - W3 33000:General topics and reviews KW - W 30965:Miscellaneous, Reviews KW - W3 33180:Gene based (protocols, clinical trials, and animal models) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17194999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=In+utero+gene+therapy%3A+The+case+against&rft.au=Billings%2C+PR&rft.aulast=Billings&rft.aufirst=PR&rft.date=1999-03-01&rft.volume=5&rft.issue=3&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Germ cells; Gene therapy; Reviews; Ethics; Uterus ER - TY - JOUR T1 - Interference between Effector RNAs Expressed from Conventional Dual-Function Anti-HIV Retroviral Vectors Can Be Circumvented Using Dual-Effector-Cassette Retroviral Vectors AN - 17577090; 4489905 AB - Coexpression of different effector molecules from a single vector (a dual-function vector) may provide enhanced efficacy. Thus far most of the reported anti-HIV dual-function vectors express different effector RNAs as a chimeric molecule. In our study involving retroviral vectors coexpressing a U5 ribozyme and either an anti-tat or anti-rev antisense RNA, chimeric vectors exhibit poor potency in several important functional aspects, including inhibition of HIV replication, protection against cytopathic effects, and suppression of target gene function. Surprisingly, such a poor efficacy of chimeric vector function was not associated with a lower level of effector RNA expression. These results indicate that expression of two effector RNAs as a chimeric molecule can lead to interference, reducing their global biological effects. More importantly, we have demonstrated that such interference can be avoided by coexpressing these effector RNAs as separate molecules through a new dual-function vector, called a dual-effector cassette (Dec) vector, developed in this study. We also define some of the design alterations that might affect the efficacy of the Dec vector and demonstrate that forward-designed Dec vectors are more efficacious than reverse-designed Dec vectors, which express a lower level of effector RNA owing to the instability of the 5 theta effector cassettes in the provirus. We believe that the principle of Dec vector design may also be applicable for the coexpression of other therapeutic RNA effectors in many gene therapy applications. JF - Human Gene Therapy AU - Peng, H AU - Callison, D AU - Li, P AU - Burrell, C J AD - Gene Therapy Center, Mineral Metabolism (151), J.L. Pettis VA Medical Center, University of Loma Linda, 11201 Benton Street, Loma Linda, CA 92354, USA, Pengh@ll.visn22.med.va.gov Y1 - 1999/02/10/ PY - 1999 DA - 1999 Feb 10 SP - 449 EP - 462 VL - 10 IS - 3 SN - 1043-0342, 1043-0342 KW - man KW - Retrovirus KW - human immunodeficiency virus KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Expression vectors KW - Antisense KW - Gene therapy KW - RNA KW - W3 33181:Gene therapy vectors KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17577090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Interference+between+Effector+RNAs+Expressed+from+Conventional+Dual-Function+Anti-HIV+Retroviral+Vectors+Can+Be+Circumvented+Using+Dual-Effector-Cassette+Retroviral+Vectors&rft.au=Peng%2C+H%3BCallison%2C+D%3BLi%2C+P%3BBurrell%2C+C+J&rft.aulast=Peng&rft.aufirst=H&rft.date=1999-02-10&rft.volume=10&rft.issue=3&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2F10430349950018896 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Expression vectors; RNA; Antisense; Gene therapy DO - http://dx.doi.org/10.1089/10430349950018896 ER - TY - JOUR T1 - Comparison of Impairment and Disability Measures for Assessing Severity of, and Improvement in, Aphasia AN - 85516760; 200010376 AB - The relationship between impairment & disability measures was examined for assessing initial severity of, & change in, aphasia. Twenty-two aphasic adults were administered three aphasia tests at two points in time. Videotaped speech samples were collected & scored using Correct Information Unit & Main Concept analyses. Ten normal listeners viewed randomized, paired pre- & post-samples to provide a social judgment of change. Most impairment measures were significantly related, & most predicted disability scores. Change on most impairment measures was not related, & change on only one impairment measure predicted change in disability. Three of the connected speech measures predicted listener judgments. Thus, some redundancy was observed among measures in the ability to determine severity & measure change, but the results do not support one measure as an adequate replacement for another. Moreover, the relationship between change on the standardized impairment & disability measures & listener perception of change was, at best, moderate. 6 Tables, 19 References. Adapted from the source document JF - Aphasiology AU - Ross, Katherine B AU - Wertz, Robert T AD - Veterans Administration Medical Center, Nashville, TN Y1 - 1999/02// PY - 1999 DA - February 1999 SP - 113 EP - 124 VL - 13 IS - 2 SN - 0268-7038, 0268-7038 KW - Aphasia (03400) KW - Diagnostic Tests (18550) KW - Prognostic Tests (68150) KW - Test Validity and Reliability (88800) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85516760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Comparison+of+Impairment+and+Disability+Measures+for+Assessing+Severity+of%2C+and+Improvement+in%2C+Aphasia&rft.au=Ross%2C+Katherine+B%3BWertz%2C+Robert+T&rft.aulast=Ross&rft.aufirst=Katherine&rft.date=1999-02-01&rft.volume=13&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Diagnostic Tests (18550); Prognostic Tests (68150); Test Validity and Reliability (88800) ER - TY - JOUR T1 - Decision latencies for phonological and semantic information in object identification. AN - 85314454; pmid-10190991 AB - Several on-line studies in the literature have been cited in support of a two-stage model of name-retrieval in which semantic processing precedes and mediates access to phonology. Because of inconsistencies in prior studies an off-line experiment was designed to provide converging evidence on this issue. An experiment is reported in which young and elderly adults were required to give speeded judgments of whether a pictured object matched a named category, a named physical attribute, or a rhyming cue. Latencies for the young adults were fastest for category judgments and slowest for rhyming judgments. For the elderly adults physical attributes and rhyming judgments were equivalent. Results are discussed in terms of "lemma" theory in object naming. (Copyright 1999 Academic Press.) JF - Brain and language AU - Goodglass, H AU - Wingfield, A AU - Ward, S E AD - Aphasia Research Center, Boston University School of Medicine, Boston, MA 02130, USA. goodglass@boston.va.gov Y1 - 1999/02/01/ PY - 1999 DA - 1999 Feb 01 SP - 294 EP - 305 VL - 66 IS - 2 SN - 0093-934X, 0093-934X KW - Index Medicus KW - National Library of Medicine KW - Aging -- physiology KW - Humans KW - Phonetics KW - Adult KW - Aged KW - Middle Aged KW - Female KW - Male KW - Reaction Time KW - Decision Making KW - Semantics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85314454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+language&rft.atitle=Decision+latencies+for+phonological+and+semantic+information+in+object+identification.&rft.au=Goodglass%2C+H%3BWingfield%2C+A%3BWard%2C+S+E&rft.aulast=Goodglass&rft.aufirst=H&rft.date=1999-02-01&rft.volume=66&rft.issue=2&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=Brain+and+language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-01-15 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Detection of the proto-oncogene eIF4E in larynx and hypopharynx cancers. AN - 85312887; pmid-10037284 AB - BACKGROUND: The proto-oncogene eIF4E has been found to be elevated in head and neck squamous cell carcinomas. In an earlier prospective study overexpression of eIF4E, detected by Western blot analysis, in histologically normal surgical margins correlated with an increased local-regional recurrence rate during a 1-year follow-up. OBJECTIVE: To test the reverse hypothesis that absence of overexpression of eIF4E in the surgical margins is a predictor for long-term survival in patients with squamous cell carcinoma of the head and neck. DESIGN: A retrospective analysis was performed on 31 patients who underwent surgery for squamous cell carcinoma of the larynx or hypopharynx. Immunohistochemical analysis was used to detect eIF4E on paraffin embedded sections of the tumor and the histologically negative surgical margins. RESULTS: All 31 patients overexpressed eIF4E in the tumors. Thirteen patients had no detectable level of eIF4E in the margins, and only 1 had a local-regional recurrence. The average disease-free interval in this group of patients was 82.08 months. The remaining 18 patients all overexpressed eIF4E in the surgical margins (eIF4E score range, 5-80). Twelve (67%) of these patients developed a recurrence; the average disease-free interval was 31.95 months. Cox regression analysis showed that eIF4E in the margin (P= .01), nodes (P= .06), site (P= .02), and age (P= .02) had significant effects on the disease-free interval. The Kaplan-Meier survival curves were significantly different for eIF4E-positive and eIF4E-negative margins (P = .002). CONCLUSIONS: eIF4E in the surgical margins is an independent prognostic factor and its absence in surgical margins may predict long-term survival. Detecting eIF4E in the margins may improve survival by determining which patients would benefit from further resection or adjuvant therapy. JF - Archives of otolaryngology--head & neck surgery AU - Franklin, S AU - Pho, T AU - Abreo, F W AU - Nassar, R AU - De Benedetti, A AU - Stucker, F J AU - Nathan, C A AD - Department of Otolaryngology-Head and Neck Surgery, Louisiana State University Medical Center and Veterans Administration Medical Center, Shreveport 71130, USA. Y1 - 1999/02// PY - 1999 DA - February 1999 SP - 177 EP - 182 VL - 125 IS - 2 SN - 0886-4470, 0886-4470 KW - Abridged Index Medicus; Index Medicus KW - National Library of Medicine KW - Disease-Free Survival KW - Humans KW - Retrospective Studies KW - Laryngeal Neoplasms -- surgery KW - Aged KW - Hypopharynx -- pathology KW - Eukaryotic Initiation Factor-4E KW - Aged, 80 and over KW - Carcinoma, Squamous Cell -- pathology KW - Laryngeal Neoplasms -- mortality KW - Hypopharyngeal Neoplasms -- mortality KW - Adult KW - Larynx -- pathology KW - Male KW - Neoplasm Recurrence, Local -- mortality KW - Neoplasm Staging KW - Hypopharyngeal Neoplasms -- surgery KW - Hypopharyngeal Neoplasms -- pathology KW - Carcinoma, Squamous Cell -- mortality KW - Prognosis KW - Carcinoma, Squamous Cell -- surgery KW - Survival Rate KW - Middle Aged KW - Laryngeal Neoplasms -- pathology KW - Neoplasm Recurrence, Local -- surgery KW - Female KW - Neoplasm Recurrence, Local -- pathology KW - Tumor Markers, Biological -- analysis KW - Peptide Initiation Factors -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85312887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+otolaryngology--head+%26+neck+surgery&rft.atitle=Detection+of+the+proto-oncogene+eIF4E+in+larynx+and+hypopharynx+cancers.&rft.au=Franklin%2C+S%3BPho%2C+T%3BAbreo%2C+F+W%3BNassar%2C+R%3BDe+Benedetti%2C+A%3BStucker%2C+F+J%3BNathan%2C+C+A&rft.aulast=Franklin&rft.aufirst=S&rft.date=1999-02-01&rft.volume=125&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Archives+of+otolaryngology--head+%26+neck+surgery&rft.issn=08864470&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-01-15 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Hydrochlorothiazide-induced pulmonary edema and associated immunologic changes. AN - 69628525; 10084412 AB - To describe a patient with noncardiogenic acute pulmonary edema induced by hydrochlorothiazide and to investigate the possible involvement of an immunologic mechanism in this adverse reaction. A 66-year-old Hispanic woman developed acute pulmonary edema 30 minutes after the ingestion of one tablet of triamterene 75 mg/hydrochlorothiazide 50 mg. The reaction was associated with hemoconcentration; a decreased white blood cell count with a shift to a predominance of polymorphonuclear cells; decreased serum immunoglobulin (Ig) G, IgG1, and IgG4; and increased serum IgM and complement 3 concentrations. Although there have been 35 reports of cases of hydrochlorothiazide-induced pulmonary edema, the etiology of this adverse reaction remains unknown. The observations presented in this case report, along with commonalities with previously reported cases, suggest that granulocytic infiltration into the lungs and IgG deposition in alveolar membranes may play a role in hydrochlorothiazide-induced pulmonary edema. Noncardiogenic pulmonary edema may be an immunologically mediated rare idiosyncratic reaction to hydrochlorothiazide. JF - The Annals of pharmacotherapy AU - Bernal, C AU - Patarca, R AD - Department of Internal Medicine, Miami Veterans Administration Medical Center, FL, USA. Y1 - 1999/02// PY - 1999 DA - February 1999 SP - 172 EP - 174 VL - 33 IS - 2 SN - 1060-0280, 1060-0280 KW - Antihypertensive Agents KW - 0 KW - Immunoglobulins KW - Hydrochlorothiazide KW - 0J48LPH2TH KW - Index Medicus KW - Phenotype KW - Acute Disease KW - Lymphocyte Count KW - Humans KW - Granulocytes -- immunology KW - Aged KW - Immunoglobulins -- blood KW - Female KW - Pulmonary Edema -- immunology KW - Antihypertensive Agents -- adverse effects KW - Pulmonary Edema -- chemically induced KW - Hydrochlorothiazide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69628525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Hydrochlorothiazide-induced+pulmonary+edema+and+associated+immunologic+changes.&rft.au=Bernal%2C+C%3BPatarca%2C+R&rft.aulast=Bernal&rft.aufirst=C&rft.date=1999-02-01&rft.volume=33&rft.issue=2&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-06-03 N1 - Date created - 1999-06-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Pharmacother. 1999 Sep;33(9):1010-1 [10492511] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Targeted cytotoxic analog of luteinizing hormone-releasing hormone AN-207 inhibits the growth of PC-82 human prostate cancer in nude mice. AN - 69573211; 9973101 AB - Receptors for luteinizing hormone-releasing hormone (LH-RH) found in prostate cancers might be used for targeting of chemotherapeutic agents. Doxorubicin derivative 2-pyrrolinodoxorubicin (AN-201) can be linked to carrier analog [D-Lys6]LH-RH to form the targeted cytotoxic analog of LH-RH, AN-207. We evaluated the effects of AN-207 and its components on the growth of LH-RH receptor-positive human prostate cancer PC-82 xenografted into nude mice. Analog AN-207, radical AN-201, carrier [D-Lys6]LH-RH, or a mixture of [D-Lys6]LH-RH and AN-201 were injected intravenously once at doses of 200 nmol/kg. Tumor growth, body weight, total WBC counts, and serum prostate-specific antigen (PSA) were determined. Receptors for LH-RH on PC-82 tumors were evaluated, and the expression of mRNA for LH-RH receptors was assessed by RT-PCR. Eight weeks after administration of cytotoxic analog AN-207, there was a 67.8% reduction in tumor volume (P < 0.01), 70.7% decrease in tumor burden (P < 0.01), and 36.5% decrease in serum PSA levels (P < 0.01) as compared with controls. Only one of 8 animals treated with AN-207 died. Cytotoxic radical AN-201 caused a 34.2% (not significant, NS) reduction in tumor volume with no change in serum PSA, and killed 3 of 8 mice due to toxicity. Carrier [D-Lys6]LH-RH and the unconjugated mixture of [D-Lys6]LH-RH and AN-201 had no effect on tumor growth. LH-RH receptors as well as the expression of their mRNA were found in PC-82 tumors. JF - The Prostate AU - Koppán, M AU - Nagy, A AU - Schally, A V AU - Plonowski, A AU - Halmos, G AU - Arencibia, J M AU - Groot, K AD - Endocrine, Polypeptide and Cancer Institute, Veterans Administration Medical Center, New Orleans, Louisiana 70112-1262, USA. Y1 - 1999/02/01/ PY - 1999 DA - 1999 Feb 01 SP - 151 EP - 158 VL - 38 IS - 2 SN - 0270-4137, 0270-4137 KW - Antineoplastic Agents KW - 0 KW - Pyrroles KW - Receptors, LHRH KW - AN 204 KW - 175795-76-3 KW - AN 207 KW - 179910-83-9 KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - LHRH, Lys(6)- KW - 52671-12-2 KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Polymerase Chain Reaction KW - Animals KW - Adenocarcinoma -- metabolism KW - Tumor Cells, Cultured KW - Humans KW - Transplantation, Heterologous KW - Models, Chemical KW - Mice, Nude KW - Mice KW - Pyrroles -- pharmacology KW - Male KW - Receptors, LHRH -- metabolism KW - Adenocarcinoma -- pathology KW - Prostatic Neoplasms -- metabolism KW - Prostatic Neoplasms -- pathology KW - Drug Delivery Systems KW - Doxorubicin -- analogs & derivatives KW - Doxorubicin -- pharmacology KW - Gonadotropin-Releasing Hormone -- pharmacology KW - Gonadotropin-Releasing Hormone -- analogs & derivatives KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69573211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Prostate&rft.atitle=Targeted+cytotoxic+analog+of+luteinizing+hormone-releasing+hormone+AN-207+inhibits+the+growth+of+PC-82+human+prostate+cancer+in+nude+mice.&rft.au=Kopp%C3%A1n%2C+M%3BNagy%2C+A%3BSchally%2C+A+V%3BPlonowski%2C+A%3BHalmos%2C+G%3BArencibia%2C+J+M%3BGroot%2C+K&rft.aulast=Kopp%C3%A1n&rft.aufirst=M&rft.date=1999-02-01&rft.volume=38&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=The+Prostate&rft.issn=02704137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-02-24 N1 - Date created - 1999-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preferential interactions of fluorescent probe Prodan with cholesterol. AN - 69565222; 9916026 AB - The fluorescent probe Prodan has been widely used as a probe of model and biological membranes. Its fluorescent maxima in phospholipid bilayers vary as a function of phase state, with maxima at 485 for the liquid crystal Lalpha, 435 nm for the gel L'beta, and 507 nm for the interdigitated gel LbetaI phase, with excitation at 359 nm. These spectral changes have been used for the detection of phase changes among these phases. In the present study, the fluorescent properties and partition coefficients of Prodan in model membranes of phosphatidylcholines and phosphatidylethanols have been studied as a function of lipid phase state and cholesterol content. It is shown that the Prodan spectrum in the presence of cholesterol no longer reflects the known phase state of the lipid; in each phase state, the presence of cholesterol leads to a spectrum with the maximum at 435 nm, characteristic of the noninterdigitated gel phase. The partition coefficient of Prodan into these lipids also varies with the phase state, giving values of 0.35 x 10(4) in the interdigitated gel, 1.8 x 10(4) in the noninterdigitated gel, and 7. 6 x 10(4) in the liquid crystal phase. In the presence of cholesterol these partition coefficients are increased to 13 x 10(4) for the liquid crystal and the gel phase, and 5.1 x 10(4) in the presence of 100 mg/ml ethanol. These results suggest that Prodan has preferential interactions with cholesterol, and is thus not a randomly distributed fluorescent reporter probe in membranes containing cholesterol. These results suggest that Prodan should be used only with great caution in complex lipid mixtures, particularly biological membranes. JF - Biophysical journal AU - Bondar, O P AU - Rowe, E S AD - Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66103, and Veterans Administration Medical Center, Kansas City, Missouri 64128 USA. Y1 - 1999/02// PY - 1999 DA - February 1999 SP - 956 EP - 962 VL - 76 IS - 2 SN - 0006-3495, 0006-3495 KW - 1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanol KW - 0 KW - Fluorescent Dyes KW - Lipid Bilayers KW - Liposomes KW - Phosphatidic Acids KW - Phospholipids KW - 1,2-Dipalmitoylphosphatidylcholine KW - 2644-64-6 KW - prodan KW - 70504-01-7 KW - Cholesterol KW - 97C5T2UQ7J KW - 2-Naphthylamine KW - CKR7XL41N4 KW - Index Medicus KW - Spectrometry, Fluorescence KW - Phospholipids -- chemistry KW - Cell Membrane -- chemistry KW - Lipid Bilayers -- chemistry KW - 1,2-Dipalmitoylphosphatidylcholine -- chemistry KW - Liposomes -- chemistry KW - Phosphatidic Acids -- chemistry KW - 2-Naphthylamine -- metabolism KW - Fluorescent Dyes -- metabolism KW - Cholesterol -- metabolism KW - 2-Naphthylamine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69565222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biophysical+journal&rft.atitle=Preferential+interactions+of+fluorescent+probe+Prodan+with+cholesterol.&rft.au=Bondar%2C+O+P%3BRowe%2C+E+S&rft.aulast=Bondar&rft.aufirst=O&rft.date=1999-02-01&rft.volume=76&rft.issue=2&rft.spage=956&rft.isbn=&rft.btitle=&rft.title=Biophysical+journal&rft.issn=00063495&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-03-09 N1 - Date created - 1999-03-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Biochem Biophys. 1971 Dec;147(2):436-45 [5136095] J Biol Chem. 1959 Mar;234(3):466-8 [13641241] Biochemistry. 1984 Aug 28;23(18):4038-44 [6487589] Biochim Biophys Acta. 1985 Mar 14;813(2):321-30 [3970925] Biochemistry. 1985 Nov 19;24(24):6973-8 [4074734] Nature. 1986 Jan 2-8;319(6048):70-3 [3941741] Biochim Biophys Acta. 1986 Apr 14;856(2):274-82 [3955043] Biochim Biophys Acta. 1987 Dec 11;905(2):447-53 [3689788] Biochemistry. 1988 Jan 12;27(1):399-404 [3349041] Biochemistry. 1988 Jul 12;27(14):5281-9 [3167046] Prog Lipid Res. 1988;27(4):325-59 [3076241] Biochemistry. 1989 Oct 17;28(21):8358-63 [2605189] Biochemistry. 1991 Mar 5;30(9):2463-70 [2001373] Biochemistry. 1991 Oct 1;30(39):9485-91 [1892848] Biochem Biophys Res Commun. 1991 Nov 27;181(1):166-71 [1958185] Eur J Biochem. 1992 Feb 15;204(1):127-32 [1740122] Biochemistry. 1992 Oct 6;31(39):9473-81 [1390730] Biophys J. 1993 Oct;65(4):1404-14 [8274634] Biophys J. 1995 Feb;68(2):567-73 [7696509] Biophys J. 1995 Jul;69(1):4-12 [7669908] Biochem Biophys Res Commun. 1996 Sep 13;226(2):495-7 [8806662] Biophys J. 1996 Sep;71(3):1440-9 [8874018] Biophys Chem. 1996 Oct 30;61(2-3):151-60 [8956486] Biochim Biophys Acta. 1998 Feb 2;1369(1):119-30 [9528680] Biochim Biophys Acta. 1998 Mar 13;1370(2):207-17 [9545567] Biochemistry. 1979 Jul 10;18(14):3075-8 [465454] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Potential role of the gene transcription factor cyclic AMP-responsive element binding protein in ethanol withdrawal-related anxiety. AN - 69552977; 9918601 AB - This investigation examined the effects of acute and chronic ethanol exposure and its withdrawal on the cAMP-responsive element binding protein (CREB) and the activator protein-1 (AP-1) gene transcription factors in the rat brain. The anxiogenic effects of ethanol withdrawal after acute or protracted ethanol treatment of rats were measured by the elevated plus-maze (EPM) test. It was observed that ethanol withdrawal after acute ethanol treatment has no effect on open-arm activity (percent of open-arm entries and the mean percent of time spent on the open arms) of rats on the EPM test. On the other hand, the time course studies of the development of anxiety during ethanol withdrawal (0, 12, 24, and 72 h) after 15 days of ethanol treatment indicate that peak anxiety (significant decrease in open-arm activity) occurred at 24 h of ethanol withdrawal in rats. It was observed that acute ethanol treatment and its withdrawal (24 h) had no effect on CRE- or AP-1 DNA-binding activities in the rat cortex as determined by the electrophoretic gel-mobility shift assay. It was also found that chronic ethanol treatment and its withdrawal (24 h) had no effect on AP-1 DNA-binding activity in the rat cortex. Investigation of the time course studies of changes in CRE-DNA-binding activity during ethanol withdrawal (0, 12, 24, and 72 h) after 15 days of ethanol treatment indicated that the peak reduction of CRE-DNA-binding activity occurred at 24 h of ethanol withdrawal. The changes in the immunolabeling of the CREB-related target, that is, brain-derived neurotrophic factor (BDNF), in the rat cortex during chronic ethanol treatment and its withdrawal (24 h) were examined using western blotting. It was found that 24 h but not 0 h of ethanol withdrawal after 15 days of ethanol treatment caused a significant decrease in the immunolabeling of BDNF in the rat cortex. Fluoxetine (alone) treatment of rats for 1 or 15 days had no effect on open-arm activity and cortical CRE-DNA-binding activity. However, when fluoxetine was administered concurrently with ethanol treatment for 15 days, it caused a reversal of the anxiogenic effects of ethanol withdrawal and antagonized the down-regulation of CRE-DNA-binding activity and of the decrease in immunolabeling of BDNF in the cortices of ethanol-withdrawn rats. On the other hand, acute fluoxetine treatment produced normalization of the reduction of cortical CRE-DNA binding in ethanol-withdrawn rats (24 h) but did not reach the level of significance compared with normal control rats. Acute fluoxetine treatment had no effect on anxiety in ethanol-withdrawn rats. Taken together, these results suggest the possibility that decreased CRE-DNA-binding activity in the rat cortex may be associated with the molecular mechanisms of ethanol dependence (i.e., ethanol withdrawal-related anxiety). JF - The Journal of pharmacology and experimental therapeutics AU - Pandey, S C AU - Zhang, D AU - Mittal, N AU - Nayyar, D AD - The Psychiatry Research Institute, Department of Psychiatry, College of Medicine, University of Illinois, Veterans Administration Chicago Health Care System (West Side Division) 60612, USA. Y1 - 1999/02// PY - 1999 DA - February 1999 SP - 866 EP - 878 VL - 288 IS - 2 SN - 0022-3565, 0022-3565 KW - Central Nervous System Depressants KW - 0 KW - Cyclic AMP Response Element-Binding Protein KW - Transcription Factor AP-1 KW - Fluoxetine KW - 01K63SUP8D KW - Ethanol KW - 3K9958V90M KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Fluoxetine -- pharmacology KW - Cerebral Cortex -- metabolism KW - Transcription Factor AP-1 -- metabolism KW - DNA -- metabolism KW - Time Factors KW - Male KW - Anxiety -- metabolism KW - Cyclic AMP Response Element-Binding Protein -- metabolism KW - Central Nervous System Depressants -- toxicity KW - Substance Withdrawal Syndrome -- physiopathology KW - Substance Withdrawal Syndrome -- metabolism KW - Substance Withdrawal Syndrome -- etiology KW - Cyclic AMP Response Element-Binding Protein -- physiology KW - Ethanol -- toxicity KW - Anxiety -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69552977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Potential+role+of+the+gene+transcription+factor+cyclic+AMP-responsive+element+binding+protein+in+ethanol+withdrawal-related+anxiety.&rft.au=Pandey%2C+S+C%3BZhang%2C+D%3BMittal%2C+N%3BNayyar%2C+D&rft.aulast=Pandey&rft.aufirst=S&rft.date=1999-02-01&rft.volume=288&rft.issue=2&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-02-22 N1 - Date created - 1999-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hemolysin as a virulence factor for systemic infection with isolates of Mycobacterium avium complex AN - 17149951; 4449552 AB - Isolates of the Mycobacterium avium complex were examined for hemolysin expression. Only invasive isolates of M. avium were observed to be hemolytic (P < 0.001), with activity the greatest for isolates of serovars 4 and 8. Thus, M. avium hemolysin appears to represent a virulence factor necessary for invasive disease. JF - Journal of Clinical Microbiology AU - Maslow, J N AU - Dawson, D AU - Carlin, E A AU - Holland, S M AD - Research Service (151), VA Medical Center, 150 South Huntington Ave., Boston, MA 02130, USA, maslow.joel_n.md@boston.va.gov Y1 - 1999/02// PY - 1999 DA - Feb 1999 SP - 445 EP - 446 VL - 37 IS - 2 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Virulence KW - Mycobacterium avium KW - Disseminated infection KW - Hemolysins KW - Toxins KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17149951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Hemolysin+as+a+virulence+factor+for+systemic+infection+with+isolates+of+Mycobacterium+avium+complex&rft.au=Maslow%2C+J+N%3BDawson%2C+D%3BCarlin%2C+E+A%3BHolland%2C+S+M&rft.aulast=Maslow&rft.aufirst=J&rft.date=1999-02-01&rft.volume=37&rft.issue=2&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium avium; Virulence; Toxins; Hemolysins; Disseminated infection ER - TY - JOUR T1 - Verb Naming in Normal Aging AN - 85494090; 200005990 AB - Few studies have examined verb naming in normal aging, although decline in the ability to name nouns has been well documented. This study examined longitudinal performance on the Action Naming Test, a confrontation naming test for verbs. The purpose of this study was to confirm the verb naming deficit associated with aging, which was previously seen only in cross-sectional studies, & to provide additional normative data on verb naming ability that may prove useful to studies on verb naming in populations with brain dysfunction. Healthy men & women (N = 66, aged 30-79) were each administered the test three times over a 7-year span. Test performance showed a significant decline over time for all participants except the youngest group. Longitudinal methodology supports the conclusion that this finding of a decline in verb naming ability arises from true age-related changes & not from cohort differences. 4 Tables, 5 Figures, 35 References. Adapted from the source document JF - Applied Neuropsychology AU - Ramsay, Christine Barth AU - Nicholas, Marjorie AU - Au, Rhoda AU - Obler, Loraine K AU - Albert, Martin L AD - c/o Nicholas-Dept Veterans Affairs Medical Center, Boston, MA nicholas.marjorie@boston.va.gov Y1 - 1999///0, PY - 1999 DA - 0, 1999 SP - 57 EP - 67 VL - 6 IS - 2 SN - 0908-4282, 0908-4282 KW - Elderly (21350) KW - Age Differences (01150) KW - Lexical Access (46630) KW - Verbs (93900) KW - Memory Disorders (52800) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85494090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Neuropsychology&rft.atitle=Verb+Naming+in+Normal+Aging&rft.au=Ramsay%2C+Christine+Barth%3BNicholas%2C+Marjorie%3BAu%2C+Rhoda%3BObler%2C+Loraine+K%3BAlbert%2C+Martin+L&rft.aulast=Ramsay&rft.aufirst=Christine&rft.date=1999-01-01&rft.volume=6&rft.issue=2&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Applied+Neuropsychology&rft.issn=09084282&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Lexical Access (46630); Age Differences (01150); Elderly (21350); Memory Disorders (52800); Verbs (93900) ER - TY - JOUR T1 - Respiratory responses to sudden pressure venting during stop consonant production. AN - 85414154; pmid-10567826 AB - Twenty healthy adults, age range 20-55 years, participated in a study to assess the responses of the upper airway to sudden, unanticipated pressure venting during speech production. A computer was used to open or close a valve in a random fashion during one of two productions of the word 'hamper'. The SAR System (Microtronics Corp., Chapel Hill, N.C., USA) was used to collect and monitor respiratory variables associated with speech production. Results indicated no significant changes in duration between vented and unvented conditions. Although intraoral pressure was reduced under vented conditions, the magnitude was sufficient for sound generation. Respiratory effort increased when the airway was suddenly vented, suggesting a compensatory response to experimental perturbation. However, the response contrasted somewhat from what has been observed in patients with velopharyngeal inadequacy, indicating that the strategy used may be different. Copyright 1999 S. Karger AG, Basel JF - Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) AU - Hammond, C S AU - Warren, D W AU - Mayo, R AU - Zajac, D AD - University of North Carolina, Craniofacial Center, Chapel Hill, NC, USA. hammond.carol@forum.va.gov Y1 - 1999 PY - 1999 DA - 1999 SP - 250 EP - 260 VL - 51 IS - 6 SN - 1021-7762, 1021-7762 KW - Index Medicus KW - National Library of Medicine KW - Velopharyngeal Insufficiency -- physiopathology KW - Reference Values KW - Humans KW - Adult KW - Cleft Palate -- physiopathology KW - Middle Aged KW - Air Pressure KW - Female KW - Male KW - Airway Resistance -- physiology KW - Pulmonary Ventilation -- physiology KW - Phonation -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85414154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Folia+phoniatrica+et+logopaedica+%3A+official+organ+of+the+International+Association+of+Logopedics+and+Phoniatrics+%28IALP%29&rft.atitle=Respiratory+responses+to+sudden+pressure+venting+during+stop+consonant+production.&rft.au=Hammond%2C+C+S%3BWarren%2C+D+W%3BMayo%2C+R%3BZajac%2C+D&rft.aulast=Hammond&rft.aufirst=C&rft.date=1999-01-01&rft.volume=51&rft.issue=6&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Folia+phoniatrica+et+logopaedica+%3A+official+organ+of+the+International+Association+of+Logopedics+and+Phoniatrics+%28IALP%29&rft.issn=10217762&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Technological applications in the treatment of acquired neurogenic communication and swallowing disorders in adults. AN - 85312412; pmid-10480495 AB - Clinicians can use the computer as an effective clinical tool by incorporating what is known about neurogenic communications disorders, treatment, and technology. Computers can be used to administer activities designed by clinicians, vary stimulus characteristics, adjust response requirements, present cues, and select tasks, all in response to patient performance. Specialized devices can be used to measure small physiologic changes, help patients communicate with and control their environment, and allow clinicians to view closely what we could only imagine only a few years ago. Users of technology must focus not only on effectiveness and operational efficiency, but also ensure an optimal quality of treatment. This article reviews many of the ways technology is used in the treatment of people suffering from neurogenic communication and swallowing problems. JF - Seminars in speech and language AU - Katz, R C AU - Hallowell, B AD - Audiology and Speech Pathology Department, Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ 85012-1892, USA. richard.katz@med.va.gov Y1 - 1999 PY - 1999 DA - 1999 SP - 251 EP - 268 VL - 20 IS - 3 SN - 0734-0478, 0734-0478 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Middle Aged KW - Male KW - Therapy, Computer-Assisted -- methods KW - Brain -- physiopathology KW - Aphasia -- physiopathology KW - Deglutition Disorders -- therapy KW - Educational Technology KW - Aphasia -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85312412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+speech+and+language&rft.atitle=Technological+applications+in+the+treatment+of+acquired+neurogenic+communication+and+swallowing+disorders+in+adults.&rft.au=Katz%2C+R+C%3BHallowell%2C+B&rft.aulast=Katz&rft.aufirst=R&rft.date=1999-01-01&rft.volume=20&rft.issue=3&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Seminars+in+speech+and+language&rft.issn=07340478&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-01-15 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The functional anatomy of the normal human auditory system: responses to 0.5 and 4.0 kHz tones at varied intensities. AN - 85219271; pmid-10022496 AB - Most functional imaging studies of the auditory system have employed complex stimuli. We used positron emission tomography to map neural responses to 0.5 and 4.0 kHz sine-wave tones presented to the right ear at 30, 50, 70 and 90 dB HL and found activation in a complex neural network of elements traditionally associated with the auditory system as well as non-traditional sites such as the posterior cingulate cortex. Cingulate activity was maximal at low stimulus intensities, suggesting that it may function as a gain control center. In the right temporal lobe, the location of the maximal response varied with the intensity, but not with the frequency of the stimuli. In the left temporal lobe, there was evidence for tonotopic organization: a site lateral to the left primary auditory cortex was activated equally by both tones while a second site in primary auditory cortex was more responsive to the higher frequency. Infratentorial activations were contralateral to the stimulated ear and included the lateral cerebellum, the lateral pontine tegmentum, the midbrain and the medial geniculate. Contrary to predictions based on cochlear membrane mechanics, at each intensity, 4.0 kHz stimuli were more potent activators of the brain than the 0.5 kHz stimuli. JF - Cerebral Cortex AU - Lockwood, A H AU - Salvi, Richard J AU - Coad, M L AU - Arnold, S A AU - Wack, D S AU - Murphy, B W AU - Burkard, R F AD - Centers for Positron Emission Tomography, Veterans Administration Western New York Health Care System, and State University of New York, University at Buffalo, 14215, USA.; Department of Communicative Disorders and Sciences, College of Arts and Sciences, State University of New York at Buffalo PY - 1999 SP - 65 EP - 76 VL - 9 IS - 1 SN - 1047-3211, 1047-3211 KW - Reference Values KW - Support, U.S. Gov't, P.H.S. KW - In Vitro KW - Audiometry KW - Auditory Pathways KW - Human KW - Animal KW - Cerebrovascular Circulation KW - Nerve Net KW - Comparative Study KW - Excitatory Postsynaptic Potentials KW - Adult KW - Support, Non-U.S. Gov't KW - Tomography, Emission-Computed KW - Acoustic Stimulation KW - Male KW - Female KW - Brain Mapping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85219271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cerebral+Cortex&rft.atitle=The+functional+anatomy+of+the+normal+human+auditory+system%3A+responses+to+0.5+and+4.0+kHz+tones+at+varied+intensities.&rft.au=Lockwood%2C+A+H%3BSalvi%2C+Richard+J%3BCoad%2C+M+L%3BArnold%2C+S+A%3BWack%2C+D+S%3BMurphy%2C+B+W%3BBurkard%2C+R+F&rft.aulast=Lockwood&rft.aufirst=A&rft.date=1999-01-01&rft.volume=9&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Cerebral+Cortex&rft.issn=10473211&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Commentary on "Gemcitabine: single-agent and combination therapy in non-small cell lung cancer". The Oncologist 1999;4:241-251. AN - 69870579; 10394592 JF - The oncologist AU - Edelman, M J AD - Veterans Administration, Northern California Healthcare System, Martinez 94553-4612, USA. mjedelman@ucdavis.edu Y1 - 1999 PY - 1999 DA - 1999 SP - 252 EP - 255 VL - 4 IS - 3 SN - 1083-7159, 1083-7159 KW - Antimetabolites, Antineoplastic KW - 0 KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Humans KW - Treatment Outcome KW - Practice Guidelines as Topic KW - Clinical Trials as Topic KW - Research -- trends KW - Cisplatin -- administration & dosage KW - Deoxycytidine -- analogs & derivatives KW - Lung Neoplasms -- drug therapy KW - Deoxycytidine -- therapeutic use KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Deoxycytidine -- pharmacology KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Antimetabolites, Antineoplastic -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69870579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=Commentary+on+%22Gemcitabine%3A+single-agent+and+combination+therapy+in+non-small+cell+lung+cancer%22.+The+Oncologist+1999%3B4%3A241-251.&rft.au=Edelman%2C+M+J&rft.aulast=Edelman&rft.aufirst=M&rft.date=1999-01-01&rft.volume=4&rft.issue=3&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-08-17 N1 - Date created - 1999-08-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Oncologist. 1999;4(3):241-51 [10394591] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development and preliminary validation of a Satz-Mogel short form of the WAIS-III in a sample of persons with substance abuse disorders. AN - 69860224; 10395365 AB - We developed a Satz-Mogel short form of the WAIS-III and evaluated its accuracy for predicting IQs of 50 men with substance abuse disorders. Means for age, education, and Full Scale IQ were 44.20 years (SD = 7.23), 12.82years (SD = 1.53), and 98.06 (SD = 11.93). Correlations between the forms were significant for the 11 subtests (all rs> or =.79) and three IQs (all rs> or =.93). Short form estimated Verbal, Performance, and Full scale IQs were within +/-6 points of the WAIS-III 92% 80% and 90% of the time. The abbreviation may be used to estimate general intelligence, but interpretation of short-form-based IQ discrepancies should be avoided. The short form detected reliable WAIS-III Verbal-Performance IQ discrepancies only 67% of the time. JF - The International journal of neuroscience AU - Ryan, J J AU - Lopez, S J AU - Werth, T R AD - Dwight D. Eisenhower Veterans Affairs Medical Center, Leavenworth, KS 66048-5055, USA. Ryan.Joseph_J@Topeka.med.va.gov Y1 - 1999 PY - 1999 DA - 1999 SP - 131 EP - 140 VL - 98 IS - 1-2 SN - 0020-7454, 0020-7454 KW - Index Medicus KW - Severity of Illness Index KW - Reproducibility of Results KW - Humans KW - Adult KW - Male KW - Wechsler Scales KW - Substance-Related Disorders -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69860224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+neuroscience&rft.atitle=Development+and+preliminary+validation+of+a+Satz-Mogel+short+form+of+the+WAIS-III+in+a+sample+of+persons+with+substance+abuse+disorders.&rft.au=Ryan%2C+J+J%3BLopez%2C+S+J%3BWerth%2C+T+R&rft.aulast=Ryan&rft.aufirst=J&rft.date=1999-01-01&rft.volume=98&rft.issue=1-2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+neuroscience&rft.issn=00207454&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-10-26 N1 - Date created - 1999-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interactions of cocaine with nimodipine: a brief report. AN - 69671062; 10189518 AB - This double blind, placebo controlled study of acute calcium channel antagonist use during cocaine administration in five patients found that 60 mg of nimodipine treatment attenuated the systolic, but not diastolic, blood pressure effects of cocaine. In three subjects, a 90 mg dose of nimodipine showed a greater attenuation than that of 60 mg. Subjective effects of cocaine were not altered by either dose of nimodipine. JF - The American journal on addictions AU - Kosten, T R AU - Woods, S W AU - Rosen, M I AU - Pearsall, H R AD - Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA. kosten.thomas@west-haven.va.gov Y1 - 1999 PY - 1999 DA - 1999 SP - 77 EP - 81 VL - 8 IS - 1 SN - 1055-0496, 1055-0496 KW - Calcium Channel Blockers KW - 0 KW - Nimodipine KW - 57WA9QZ5WH KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Drug Interactions KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Calcium Channel Blockers -- metabolism KW - Nimodipine -- metabolism KW - Cocaine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69671062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Interactions+of+cocaine+with+nimodipine%3A+a+brief+report.&rft.au=Kosten%2C+T+R%3BWoods%2C+S+W%3BRosen%2C+M+I%3BPearsall%2C+H+R&rft.aulast=Kosten&rft.aufirst=T&rft.date=1999-01-01&rft.volume=8&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-07-16 N1 - Date created - 1999-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Course of substance abuse in patients with and without schizophrenia. AN - 69669620; 10189515 AB - The authors compared the course of Substance Use Disorders (SUD) in patients with SUD plus schizophrenia (SCZ) with those having SUD only. Data were obtained through diagnostic interviews and questionnaires on consecutive out-patients and in-patients referred for SUD to two university medical centers with alcohol-drug programs. This study revealed the SCZ-SUD patients (n = 29) had demographic characteristics, onset of their substance use, course of use/abuse, and lifetime SUD diagnoses that closely resembled those with SUD-only (n = 296). The marked similarities argue for a course of SUD in schizophrenic patients that is fully as morbid as that in SUD-only patients. The few differences in course appear linked to the following: (1) patients with SCZ using caffeine early, perhaps to relieve prodromal manifestations of schizophrenia, (2) patients with SCZ-SUD later using less or avoiding use of substances that exacerbate symptoms of schizophrenia (e.g., caffeine, cocaine, opiates), and (3) using tobacco more often to ameliorate the symptoms of schizophrenia or the side effects of medications used to treat schizophrenia. Contrary to expectation, those with comorbid SCZ-SUD employed self-help to deal with SUD as often as did the SUD-only patients. JF - The American journal on addictions AU - Westermeyer, J J AU - Schneekloth, T D AD - Department of Psychiatry, University of Minnesota/Minneapolis VAMC, USA. westermeyer.joseph@minneapolis.va.gov Y1 - 1999 PY - 1999 DA - 1999 SP - 55 EP - 64 VL - 8 IS - 1 SN - 1055-0496, 1055-0496 KW - Index Medicus KW - Severity of Illness Index KW - Age Factors KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Disease Progression KW - Diagnosis, Dual (Psychiatry) KW - Smoking -- psychology KW - Time Factors KW - Male KW - Female KW - Substance-Related Disorders -- diagnosis KW - Substance-Related Disorders -- complications KW - Schizophrenia -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69669620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Course+of+substance+abuse+in+patients+with+and+without+schizophrenia.&rft.au=Westermeyer%2C+J+J%3BSchneekloth%2C+T+D&rft.aulast=Westermeyer&rft.aufirst=J&rft.date=1999-01-01&rft.volume=8&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-07-16 N1 - Date created - 1999-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical conference on management dilemmas: progressive pneumonia in a patient receiving long-term steroid therapy. AN - 69570645; 9925094 JF - Chest AU - Schnader, J AU - Pina, E M AU - Baughman, R P AU - Glassroth, J AU - Adebonojo, S AD - Department of Medicine, Wright State University School of Medicine, Dayton VA Medical Center, OH 45428, USA. schnader.j@dayton.va.gov Y1 - 1999/01// PY - 1999 DA - January 1999 SP - 260 EP - 266 VL - 115 IS - 1 SN - 0012-3692, 0012-3692 KW - Anti-Inflammatory Agents KW - 0 KW - Antitubercular Agents KW - Prednisone KW - VB0R961HZT KW - Abridged Index Medicus KW - Index Medicus KW - Tuberculosis, Pulmonary -- pathology KW - Diagnosis, Differential KW - Humans KW - Tomography, X-Ray Computed KW - Aged KW - Biopsy KW - Lung -- pathology KW - Tuberculosis, Pulmonary -- surgery KW - Endoscopy KW - Drug Therapy, Combination KW - Thoracoscopy KW - Antitubercular Agents -- administration & dosage KW - Long-Term Care KW - Male KW - Lung Diseases, Obstructive -- pathology KW - Prednisone -- adverse effects KW - Opportunistic Infections -- pathology KW - Opportunistic Infections -- surgery KW - Histoplasmosis -- surgery KW - Lung Diseases, Fungal -- surgery KW - Lung Diseases, Fungal -- pathology KW - Histoplasmosis -- pathology KW - Anti-Inflammatory Agents -- adverse effects KW - Anti-Inflammatory Agents -- administration & dosage KW - Prednisone -- administration & dosage KW - Lung Diseases, Obstructive -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69570645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=proceeding&rft.jtitle=Chest&rft.atitle=Clinical+conference+on+management+dilemmas%3A+progressive+pneumonia+in+a+patient+receiving+long-term+steroid+therapy.&rft.au=Schnader%2C+J%3BPina%2C+E+M%3BBaughman%2C+R+P%3BGlassroth%2C+J%3BAdebonojo%2C+S&rft.aulast=Schnader&rft.aufirst=J&rft.date=1999-01-01&rft.volume=115&rft.issue=1&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-02-05 N1 - Date created - 1999-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effect of converting from pravastatin to simvastatin on the pharmacodynamics of warfarin. AN - 69570486; 9987704 AB - Forty-six adult patients maintained on warfarin therapy were converted from pravastatin to simvastatin. Mean international normalized ratio (INR) significantly increased from 2.42 to 2.74, p = 0.002. Although warfarin doses were reduced in 7 patients and increased in 4 patients following the post-conversion INR measurements, the pre- and postconversion median weekly warfarin dose of all 46 patients did not differ significantly. The number of patients with an INR > 3.0 increased significantly from 6 to 16 following the conversion. There was no report of unusual episodes of bleeding. The results indicate that antihyperlipidemic therapy can be changed safely from pravastatin to simvastatin in patients who are taking warfarin concomitantly. Additional anticoagulation monitoring is not necessary in institutions where patients are followed in formal anticoagulation clinics. JF - Journal of clinical pharmacology AU - Lin, J C AU - Ito, M K AU - Stolley, S N AU - Morreale, A P AU - Marcus, D B AD - Cardiovascular Pharmacodynamics Laboratory, Veterans Administration Healthcare System, San Diego, California, USA. Y1 - 1999/01// PY - 1999 DA - January 1999 SP - 86 EP - 90 VL - 39 IS - 1 SN - 0091-2700, 0091-2700 KW - Anticholesteremic Agents KW - 0 KW - Anticoagulants KW - Warfarin KW - 5Q7ZVV76EI KW - Simvastatin KW - AGG2FN16EV KW - Pravastatin KW - KXO2KT9N0G KW - Index Medicus KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Humans KW - International Normalized Ratio KW - Cohort Studies KW - Retrospective Studies KW - Clinical Trials as Topic KW - Aged KW - Middle Aged KW - Time Factors KW - Male KW - Female KW - Pravastatin -- pharmacology KW - Anticoagulants -- pharmacology KW - Anticholesteremic Agents -- pharmacology KW - Simvastatin -- pharmacology KW - Warfarin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69570486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pharmacology&rft.atitle=The+effect+of+converting+from+pravastatin+to+simvastatin+on+the+pharmacodynamics+of+warfarin.&rft.au=Lin%2C+J+C%3BIto%2C+M+K%3BStolley%2C+S+N%3BMorreale%2C+A+P%3BMarcus%2C+D+B&rft.aulast=Lin&rft.aufirst=J&rft.date=1999-01-01&rft.volume=39&rft.issue=1&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-04-27 N1 - Date created - 1999-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transrectal ultrasound appearance of squamous cell carcinoma involving the prostate. AN - 69368498; 10592504 AB - This report describes the transrectal ultrasound appearance of squamous cell carcinoma of the prostate. One case of squamous cell carcinoma involving the prostate by extension from a primary urethral carcinoma and a second case of radiation-induced primary prostatic squamous cell carcinoma are presented and the ultrasound findings discussed. In these 2 cases, squamous cell carcinomas involving the prostate exhibited similar transrectal ultrasound appearances. Both lesions demonstrated an irregular, anterior, relatively hyperechoic appearance. Copyright 1999 S. Karger AG, Basel JF - Urologia internationalis AU - Terris, M K AD - Section of Urology, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. mkt@icon.palo-alto.med.va.gov Y1 - 1999 PY - 1999 DA - 1999 SP - 133 EP - 135 VL - 63 IS - 2 SN - 0042-1138, 0042-1138 KW - Index Medicus KW - Neoplasms, Radiation-Induced -- diagnostic imaging KW - Rectum KW - Humans KW - Aged KW - Middle Aged KW - Urethral Neoplasms -- pathology KW - Ultrasonography KW - Male KW - Carcinoma, Squamous Cell -- diagnostic imaging KW - Prostatic Neoplasms -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69368498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urologia+internationalis&rft.atitle=Transrectal+ultrasound+appearance+of+squamous+cell+carcinoma+involving+the+prostate.&rft.au=Terris%2C+M+K&rft.aulast=Terris&rft.aufirst=M&rft.date=1999-01-01&rft.volume=63&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Urologia+internationalis&rft.issn=00421138&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-01-27 N1 - Date created - 2000-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Social resources and social function in comorbid eating and substance disorder: a matched-pairs study. AN - 69360317; 10598216 AB - To assess social resources and function among patients with comorbid Eating Disorder (ED) and substance abuse/dependence, referred to here as Substance Related Disorder (SRD). Descriptive, cross-sectional, comparative. A university medical center with an Alcohol-Drug Program located within a Department of Psychiatry. 70 patients with Substance Related Disorder and Eating Disorder (SRD-ED), matched for gender, age, and race-ethnicity with 70 SRD-only patients. A research associate assessed current social resources and social function based on data obtained from patients and collateral sources while blind to the ED status of the patient. Addiction psychiatrists made the diagnoses of SRD and ED and conducted assessments for axis 4 psychosocial stressors and axis 5 psychosocial function. SRD-ED patients had more advantageous social resources than SRD-only patients, including residence with family or friends, more education, higher socioeconomic status, and larger social networks. However, SRD-ED patients manifested martial status, employment, stressors, and coping levels similar to SRD-only patients. Several alternative explanations exist for these expected though unusual findings. Further analyses will be required to understand this lack of articulation between social resources and social function across two diagnostic groups. JF - The American journal on addictions AU - Westermeyer, J AU - Specker, S AD - Department of Psychiatry, Minneapolis Veterans Administration Medical Center, Minn. 55417, USA. Y1 - 1999 PY - 1999 DA - 1999 SP - 332 EP - 336 VL - 8 IS - 4 SN - 1055-0496, 1055-0496 KW - Index Medicus KW - Minnesota KW - Bulimia -- psychology KW - Humans KW - Bulimia -- rehabilitation KW - Comorbidity KW - Anorexia Nervosa -- psychology KW - Anorexia Nervosa -- rehabilitation KW - Cross-Sectional Studies KW - Adult KW - Bulimia -- epidemiology KW - Anorexia Nervosa -- epidemiology KW - Adolescent KW - Male KW - Female KW - Feeding and Eating Disorders -- psychology KW - Social Adjustment KW - Social Support KW - Feeding and Eating Disorders -- epidemiology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Feeding and Eating Disorders -- rehabilitation KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69360317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Social+resources+and+social+function+in+comorbid+eating+and+substance+disorder%3A+a+matched-pairs+study.&rft.au=Westermeyer%2C+J%3BSpecker%2C+S&rft.aulast=Westermeyer&rft.aufirst=J&rft.date=1999-01-01&rft.volume=8&rft.issue=4&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-01-28 N1 - Date created - 2000-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Approaches to enhance expression after adenovirus-mediated gene transfer to the carotid artery. AN - 69357714; 10599561 AB - The goal of this study was to enhance transgene expression after adenoviral-mediated gene transfer to the carotid artery. We used an adenoviral vector with a transgene that expresses beta-galactosidase, driven by the human cytomegalovirus (CMV) promoter/enhancer. The CMV promoter drives constitutive expression, and response elements within the enhancer allow inducible expression through binding of active transcription factors, such as cAMP response element binding protein (CREB) and nuclear factor kappa B (NFkappaB). Rings of rabbit carotid artery were incubated ex vivo with a replication-deficient adenovirus that expresses beta-galactosidase (AdCMV-betagal). Virus was removed from the medium, and forskolin or phorbol-12-myristate-13-acetate (PMA), which can induce activation of CREB or NFkappaB, respectively, were added to the medium. Pyrrolidine dithiocarbamate (PDTC) was used to inhibit activation of NFkappaB. Following incubation for 24 hours, beta-galactosidase activity was assessed by chemiluminescent reporter assay. Forskolin and PMA enhanced transgene expression in the carotid artery. Activity increased from 56+/-13 mU/mg protein (mean+/-SE) in rings of carotid treated with virus alone (10(9) pfu) to 159+/-23 mU/mg protein (P<0.05) in rings treated with forskolin, and to 189+/-40 mU/mg protein (P<0.05) in rings treated with PMA. Phorbol didecanoate, an inactive phorbol, did not affect expression of beta-galactosidase. After pre-incubation with PDTC prior to PMA, expression of beta-galactosidase was less than in rings incubated with PMA alone (29+/-11, P<0.05). Histochemical staining of carotid artery for beta-galactosidase demonstrated enhanced endothelial expression following administration of PMA. These findings suggest that expression after gene transfer to the carotid artery using an adenoviral vector with the CMV promoter/enhancer may be enhanced by PMA and forskolin, perhaps by activation of transcription factors. JF - Endothelium : journal of endothelial cell research AU - Christenson, S D AU - Lund, D AU - Ooboshi, H AU - Faraci, F M AU - Beverly AU - Davidson, L AU - Heistad, D D AD - Department of Internal Medicine and Center on Aging University of Iowa College of Medicine and Veterans Administration Medical Center Iowa City, 52242, USA. Y1 - 1999 PY - 1999 DA - 1999 SP - 75 EP - 82 VL - 7 IS - 1 SN - 1062-3329, 1062-3329 KW - Activating Transcription Factor 1 KW - 0 KW - DNA-Binding Proteins KW - NF-kappa B KW - Transcription Factors KW - Colforsin KW - 1F7A44V6OU KW - beta-Galactosidase KW - EC 3.2.1.23 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Endothelium, Vascular -- enzymology KW - Endothelium, Vascular -- cytology KW - Gene Transfer Techniques KW - Transcription Factors -- metabolism KW - Humans KW - Rabbits KW - Tissue Distribution KW - Transcription Factors -- genetics KW - Colforsin -- pharmacology KW - Promoter Regions, Genetic KW - beta-Galactosidase -- metabolism KW - Transcription Factors -- drug effects KW - Cytomegalovirus -- genetics KW - Tetradecanoylphorbol Acetate -- pharmacology KW - beta-Galactosidase -- genetics KW - NF-kappa B -- metabolism KW - Gene Expression -- drug effects KW - Carotid Arteries -- enzymology KW - Carotid Arteries -- cytology KW - Adenoviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69357714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endothelium+%3A+journal+of+endothelial+cell+research&rft.atitle=Approaches+to+enhance+expression+after+adenovirus-mediated+gene+transfer+to+the+carotid+artery.&rft.au=Christenson%2C+S+D%3BLund%2C+D%3BOoboshi%2C+H%3BFaraci%2C+F+M%3BBeverly%3BDavidson%2C+L%3BHeistad%2C+D+D&rft.aulast=Christenson&rft.aufirst=S&rft.date=1999-01-01&rft.volume=7&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Endothelium+%3A+journal+of+endothelial+cell+research&rft.issn=10623329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-01-05 N1 - Date created - 2000-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intra- and inter-individual correlations between cholecystokinin and corticotropin-releasing hormone concentrations in human cerebrospinal fluid. AN - 69289892; 10569131 AB - Despite strong evidence of a physiologic relationship between cholecystokinin (CCK) and corticotropin-releasing hormone (CRH) in the rat central nervous system (CNS), evidence of such a relationship between the two hormones in the human CNS is lacking. A post hoc analysis of serial concentrations of immunoreactive CCK and CRH, obtained every ten minutes from CSF continuously collected over six hours, was performed. A total of 30 subjects were studied: 15 normal volunteers, 10 patients with major depression, and 5 recently-abstinent, alcohol-dependent patients. Overall, we observed an average intra-subject correlation of +.273 (P < 0.001) between CSF CRH and CCK. Inter-subject correlations between mean CSF levels of CRH and CCK were +.948 (P = 0.0001) and +.959 (P = 0.005) in the depressed and abstinent alcoholic patients, respectively. These inter-individual correlations were significantly greater than that seen within the group of normal volunteers (r = +.318, n.s.). The present data suggest that interactions between CCK and CRH are significant in the human CNS, particularly perhaps in depressed and alcoholic patients, and that CSF samples may be used to assess elements of the relationship between these hormones. JF - Depression and anxiety AU - Geracioti, T D AU - Ekhator, N N AU - Nicholson, W E AU - Arndt, S AU - Loosen, P T AU - Orth, D N AD - Psychiatry Service, Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA. thomas.geracioti@med.va.gov Y1 - 1999 PY - 1999 DA - 1999 SP - 77 EP - 80 VL - 10 IS - 2 SN - 1091-4269, 1091-4269 KW - Cholecystokinin KW - 9011-97-6 KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - Index Medicus KW - Depressive Disorder, Major -- cerebrospinal fluid KW - Humans KW - Alcoholism -- cerebrospinal fluid KW - Adult KW - Anxiety Disorders -- cerebrospinal fluid KW - Temperance KW - Alcoholism -- psychology KW - Corticotropin-Releasing Hormone -- cerebrospinal fluid KW - Brain -- metabolism KW - Cholecystokinin -- cerebrospinal fluid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69289892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+anxiety&rft.atitle=Intra-+and+inter-individual+correlations+between+cholecystokinin+and+corticotropin-releasing+hormone+concentrations+in+human+cerebrospinal+fluid.&rft.au=Geracioti%2C+T+D%3BEkhator%2C+N+N%3BNicholson%2C+W+E%3BArndt%2C+S%3BLoosen%2C+P+T%3BOrth%2C+D+N&rft.aulast=Geracioti&rft.aufirst=T&rft.date=1999-01-01&rft.volume=10&rft.issue=2&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Depression+and+anxiety&rft.issn=10914269&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-12-13 N1 - Date created - 1999-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modeling Physical Health and Functional Health Status: The Role of Combat Exposure, Posttraumatic Stress Disorder, and Personal Resource Attributes AN - 61675914; 199905274 AB - To examine associations of combat exposure & posttraumatic stress disorder (PTSD) with physical health conditions, incorporating hardiness & social support as mediators, & using functional health status as an outcome, data were obtained from 1,632 male & female Vietnam veterans who participated in the National Vietnam Veterans Readjustment Study. Path analysis revealed that hardiness & social support operated primarily as intermediary variables between combat exposure & PTSD, & PTSD emerged as the pivotal variable explaining physical health conditions & functional health status. Gender-based differences in means & patterns of associations among variables were found. Results stress the importance of assessing trauma in clinical settings as a meaningful determinant of health outcomes. 4 Tables, 2 Figures, 68 References. Adapted from the source document. JF - Journal of Traumatic Stress AU - Taft, Casey T AU - Stern, Amy S AU - King, Lynda A AU - King, Daniel W AD - c/o Lynda King -- Boston Dept of Veterans Affairs Medical Center (116B-3), 150 South Huntington Ave, Boston, MA 02130 Y1 - 1999/01// PY - 1999 DA - January 1999 SP - 3 EP - 23 VL - 12 IS - 1 SN - 0894-9867, 0894-9867 KW - Veterans KW - Vietnam War KW - Males KW - Health Problems KW - Combat KW - Sex Differences KW - Social Support KW - Health KW - Females KW - Posttraumatic Stress Disorder KW - article KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61675914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Traumatic+Stress&rft.atitle=Modeling+Physical+Health+and+Functional+Health+Status%3A+The+Role+of+Combat+Exposure%2C+Posttraumatic+Stress+Disorder%2C+and+Personal+Resource+Attributes&rft.au=Taft%2C+Casey+T%3BStern%2C+Amy+S%3BKing%2C+Lynda+A%3BKing%2C+Daniel+W&rft.aulast=Taft&rft.aufirst=Casey&rft.date=1999-01-01&rft.volume=12&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Traumatic+Stress&rft.issn=08949867&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Health; Social Support; Combat; Sex Differences; Health Problems; Vietnam War; Veterans; Males; Females ER - TY - JOUR T1 - Alcohol and Crime among Religious Youth AN - 61664452; 200005809 AB - Questionnaire data were collected from 528 adolescents who regularly attend churches affiliated with primary Protestant denominations in a midwestern state to determine whether the delinquency syndrome argument has more validity in a religious sample than in the general population of youth. Findings support the delinquency syndrome argument in this sample of religious youth, showing that religiosity is relevant to alcohol use & not to crime. 2 Tables, 54 References. Adapted from the source document. JF - Alcoholism Treatment Quarterly AU - Rodell, Daniel E AU - Benda, Brent B AD - Social Work Service, Veterans Administration Medical Center-North Little Rock Division, AR Y1 - 1999///0, PY - 1999 DA - 0, 1999 SP - 53 EP - 66 VL - 17 IS - 4 SN - 0734-7324, 0734-7324 KW - Protestantism KW - Alcohol Abuse KW - Crime KW - Midwestern States KW - Juvenile Delinquency KW - Religiosity KW - Adolescents KW - Youth KW - article KW - 6129: addiction KW - 6146: crime & corrections UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61664452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism+Treatment+Quarterly&rft.atitle=Alcohol+and+Crime+among+Religious+Youth&rft.au=Rodell%2C+Daniel+E%3BBenda%2C+Brent+B&rft.aulast=Rodell&rft.aufirst=Daniel&rft.date=1999-01-01&rft.volume=17&rft.issue=4&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Alcoholism+Treatment+Quarterly&rft.issn=07347324&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Youth; Alcohol Abuse; Adolescents; Religiosity; Juvenile Delinquency; Crime; Midwestern States; Protestantism ER - TY - JOUR T1 - Structure and Implementation of Comprehensive State Preadmission Screening Programs for Nursing Home Applicants: 1978-1994 AN - 61640040; 200005384 AB - Examines the structure & implementation of comprehensive state preadmission screening (PAS) programs for nursing home applicants, 1978-1994, in all 50 states & the District of Columbia. A state was considered to have comprehensive PAS if a majority of nursing home applicants were screened in-person by state or contract agency staff. By 1994, 26 states had implemented these programs, with the most growth occurring during the 1980s. The primary changes in program structure were an increased reliance on private providers to screen a subset of applicants & a higher % of states screening private pay applicants. All programs but one referred or authorized the use of community-based services, while most programs diverted well over 10% of nursing home applicants. 4 Tables, 19 References. Adapted from the source document. JF - Home Health Care Services Quarterly AU - Curtis, Michael P AU - Harrington, Charlene AD - Veterans Administration Puget Sound Health Care System, Seattle, WA Y1 - 1999///0, PY - 1999 DA - 0, 1999 SP - 61 EP - 74 VL - 18 IS - 1 SN - 0162-1424, 0162-1424 KW - Admissions KW - Nursing Homes KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61640040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Home+Health+Care+Services+Quarterly&rft.atitle=Structure+and+Implementation+of+Comprehensive+State+Preadmission+Screening+Programs+for+Nursing+Home+Applicants%3A+1978-1994&rft.au=Curtis%2C+Michael+P%3BHarrington%2C+Charlene&rft.aulast=Curtis&rft.aufirst=Michael&rft.date=1999-01-01&rft.volume=18&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Home+Health+Care+Services+Quarterly&rft.issn=01621424&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Nursing Homes; Admissions ER - TY - JOUR T1 - Increasing Adherence to Substance Abuse Aftercare Group Therapy AN - 1761716473; 199903837 AB - To examine whether feedback & prompts are an effective means of increasing adherence to substance abuse aftercare group therapy beyond that found when orientation & adherence contracts are completed, 41 substance-dependent male patients completing inpatient or intensive outpatient treatment at a Veterans Affairs Medical Center in Salem, VA, were assigned to receive either attendance feedback & prompts to attend aftercare, or no feedback & no prompts. Participants who received the feedback & prompts were more likely to begin aftercare & to attend more weekly aftercare sessions. They were also less likely to be readmitted to the hospital. The clinical utility of prompts & feedback are discussed. 1 Table, 22 References. Adapted from the source document. JF - Journal of Substance Abuse Treatment AU - Lash, Steven J AU - Blosser, Sharon L AD - Substance Abuse Treatment Program (116A4), Veterens Affairs Medical Center, Salem, VA 24153 lash.s@salem.va.gov Y1 - 1999/01// PY - 1999 DA - January 1999 SP - 55 EP - 60 VL - 16 IS - 1 SN - 0740-5472, 0740-5472 KW - Relapse KW - Substance Abuse KW - Virginia KW - After Care KW - Treatment Compliance KW - Group Therapy KW - Treatment KW - Treatment Methods KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761716473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Increasing+Adherence+to+Substance+Abuse+Aftercare+Group+Therapy&rft.au=Lash%2C+Steven+J%3BBlosser%2C+Sharon+L&rft.aulast=Lash&rft.aufirst=Steven&rft.date=1999-01-01&rft.volume=16&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Substance Abuse; Group Therapy; Treatment Compliance; After Care; Treatment Methods; Treatment; Virginia; Relapse ER - TY - JOUR T1 - Multivalent group A streptococcal vaccine designed to optimize the immunogenicity of six tandem M protein fragments AN - 17108234; 4419828 AB - One of the major challenges in the development of group A streptococcal M protein-based vaccines is the multiplicity of M types expressed by these organisms. Previous studies have shown that multivalent vaccines containing as many as eight M protein fragments in tandem were immunogenic and evoked opsonic antibodies. It was also noted that the C-terminal fragments of these hybrid proteins were often not immunogenic or evoked only low levels of opsonic antibodies, suggesting that the C-terminus of the molecule may have been preferentially degraded or altered in vivo. In the present studies, we designed a hexavalent vaccine containing protective M protein peptides from types 24, 5, 6, 19, 1, and 3 group A streptococci. In order to "protect" the carboxy-terminal components, the amino-terminal M24 fragment was reiterated on the carboxy-terminal end of the construct. The hexavalent vaccine was immunogenic in laboratory animals and evoked high titers of antibodies against each of the native M proteins represented in the vaccine and bactericidal antibodies against all six stereotypes of group A streptococci. The vaccine was equally immunogenic when delivered in alum or in complete Freund's adjuvant. None of the immune sera contained antibodies that crossreacted with human heart tissue. Our results show that complex multivalent group A streptococcal vaccines can be designed in such a way that each M protein fragment is immunogenic and evokes protective antibodies. JF - Vaccine AU - Dale, J B AD - Veterans Affairs Research Service and the Department of Medicine, University of Tennessee, Memphis, TN 38104, USA, dale.james_b+@memphis.med.va.gov Y1 - 1999 PY - 1999 DA - 1999 SP - 193 EP - 200 VL - 17 IS - 2 SN - 0264-410X, 0264-410X KW - Streptococcus pyogenes KW - double prime M protein KW - man KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Antibody response KW - Vaccines KW - J 02834:Vaccination and immunization KW - F 06807:Active immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17108234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Multivalent+group+A+streptococcal+vaccine+designed+to+optimize+the+immunogenicity+of+six+tandem+M+protein+fragments&rft.au=Dale%2C+J+B&rft.aulast=Dale&rft.aufirst=J&rft.date=1999-01-01&rft.volume=17&rft.issue=2&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pyogenes; Vaccines; Antibody response ER - TY - JOUR T1 - Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice. AN - 69098065; 9864372 AB - Simple epithelia express keratins 8 (K8) and 18 (K18) as their major intermediate filament (IF) proteins. One important physiologic function of K8/18 is to protect hepatocytes from drug-induced liver injury. Although the mechanism of this protection is unknown, marked K8/18 hyperphosphorylation occurs in association with a variety of cell stresses and during mitosis. This increase in keratin phosphorylation involves multiple sites including human K18 serine-(ser)52, which is a major K18 phosphorylation site. We studied the significance of keratin hyperphosphorylation and focused on K18 ser52 by generating transgenic mice that overexpress a human genomic K18 ser52--> ala mutant (S52A) and compared them with mice that overexpress, at similar levels, wild-type (WT) human K18. Abrogation of K18 ser52 phosphorylation did not affect filament organization after partial hepatectomy nor the ability of mouse livers to regenerate. However, exposure of S52A-expressing mice to the hepatotoxins, griseofulvin or microcystin, which are associated with K18 ser52 and other keratin phosphorylation changes, resulted in more dramatic hepatotoxicity as compared with WT K18-expressing mice. Our results demonstrate that K18 ser52 phosphorylation plays a physiologic role in protecting hepatocytes from stress-induced liver injury. Since hepatotoxins are associated with increased keratin phosphorylation at multiple sites, it is likely that unique sites aside from K18 ser52, and phosphorylation sites on other IF proteins, also participate in protection from cell stress. JF - The Journal of cell biology AU - Ku, N O AU - Michie, S A AU - Soetikno, R M AU - Resurreccion, E Z AU - Broome, R L AU - Omary, M B AD - Department of Medicine, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA. Y1 - 1998/12/28/ PY - 1998 DA - 1998 Dec 28 SP - 2023 EP - 2032 VL - 143 IS - 7 SN - 0021-9525, 0021-9525 KW - Microcystins KW - 0 KW - Peptides, Cyclic KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Griseofulvin KW - 32HRV3E3D5 KW - Keratins KW - 68238-35-7 KW - microcystin KW - 77238-39-2 KW - Index Medicus KW - 3T3 Cells KW - Animals KW - Actin Cytoskeleton -- ultrastructure KW - Humans KW - Protein Processing, Post-Translational KW - Mice KW - Griseofulvin -- toxicity KW - Liver Regeneration KW - Mice, Transgenic KW - Phosphorylation KW - Hepatectomy KW - Point Mutation KW - Okadaic Acid -- pharmacology KW - Peptides, Cyclic -- toxicity KW - Genetic Predisposition to Disease KW - Amino Acid Substitution KW - Keratins -- metabolism KW - Keratins -- genetics KW - Chemical and Drug Induced Liver Injury -- genetics KW - Keratins -- chemistry KW - Intermediate Filaments -- ultrastructure KW - Intermediate Filaments -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69098065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+cell+biology&rft.atitle=Mutation+of+a+major+keratin+phosphorylation+site+predisposes+to+hepatotoxic+injury+in+transgenic+mice.&rft.au=Ku%2C+N+O%3BMichie%2C+S+A%3BSoetikno%2C+R+M%3BResurreccion%2C+E+Z%3BBroome%2C+R+L%3BOmary%2C+M+B&rft.aulast=Ku&rft.aufirst=N&rft.date=1998-12-28&rft.volume=143&rft.issue=7&rft.spage=2023&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+cell+biology&rft.issn=00219525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-02-04 N1 - Date created - 1999-02-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1979 Sep;76(9):4350-4 [388439] Curr Opin Cell Biol. 1995 Feb;7(1):118-25 [7538772] Cell. 1982 Nov;31(1):11-24 [6186379] Mol Cell Biol. 1983 Sep;3(9):1552-61 [6633533] Differentiation. 1986;33(1):61-8 [2434380] Exp Cell Res. 1995 Aug;219(2):348-57 [7543850] Biochem Biophys Res Commun. 1995 Oct 4;215(1):368-76 [7575615] J Cell Biol. 1995 Dec;131(5):1291-301 [8522590] J Cell Biol. 1995 Dec;131(5):1303-14 [8522591] J Cell Biol. 1996 Apr;133(2):345-57 [8609167] J Clin Invest. 1996 Aug 15;98(4):1034-46 [8770877] J Biol Chem. 1996 Nov 29;271(48):30404-9 [8940004] Electrophoresis. 1996 Nov;17(11):1671-6 [8982599] J Clin Invest. 1997 Jan 1;99(1):19-23 [9011570] J Cell Sci. 1997 Jan;110 ( Pt 1):23-33 [9010781] Cancer Metastasis Rev. 1996 Dec;15(4):429-44 [9034602] J Biol Chem. 1997 Mar 14;272(11):7556-64 [9054461] J Biochem. 1997 Mar;121(3):407-14 [9133607] Hepatology. 1997 May;25(5):1043-8 [9141415] Nat Genet. 1997 Jun;16(2):184-7 [9171831] J Biol Chem. 1997 Jul 11;272(28):17565-73 [9211903] J Cell Biol. 1997 Sep 22;138(6):1379-94 [9298992] Crit Rev Toxicol. 1997 Sep;27(5):495-537 [9347226] Am J Pathol. 1997 Dec;151(6):1673-83 [9403718] J Biol Chem. 1997 Dec 26;272(52):33197-203 [9407108] Science. 1998 Jan 23;279(5350):514-9 [9438837] N Engl J Med. 1998 Mar 26;338(13):873-8 [9516222] J Cell Biol. 1998 Mar 23;140(6):1441-51 [9508776] EMBO J. 1998 Apr 1;17(7):1892-906 [9524113] Hepatology. 1998 Jul;28(1):116-28 [9657104] Subcell Biochem. 1998;31:105-40 [9932491] Cancer Res. 1953 Jan;13(1):80-5 [13032955] Cancer Res. 1953 Jan;13(1):86-92 [13032956] Nature. 1970 Aug 15;227(5259):680-5 [5432063] Gastroenterology. 1976 Jun;70(6):1141-3 [131731] Differentiation. 1986;33(1):69-85 [2434381] Methods Enzymol. 1986;134:355-71 [2434826] J Pediatr. 1988 Jun;112(6):987-91 [3373408] Annu Rev Biochem. 1988;57:593-625 [3052284] J Cell Biol. 1990 Sep;111(3):1197-206 [1697294] Life Sci. 1990;47(10):859-63 [1699103] Cell. 1991 Jan 25;64(2):365-80 [1703046] Cell. 1991 Sep 20;66(6):1301-11 [1717157] Methods Enzymol. 1991;201:110-49 [1943760] Science. 1991 Nov 22;254(5035):1202-5 [1720261] J Biol Chem. 1992 Feb 25;267(6):3901-6 [1371281] Nature. 1992 Mar 19;356(6366):244-6 [1372711] Carcinogenesis. 1992 Dec;13(12):2443-7 [1282096] J Biol Chem. 1993 Feb 25;268(6):4465-72 [7680039] Genes Dev. 1993 Jul;7(7A):1191-202 [7686525] J Cell Biochem. 1993 Oct;53(2):161-8 [7693732] J Cell Biol. 1994 Oct;127(1):161-71 [7523419] Annu Rev Biochem. 1994;63:345-82 [7979242] Genes Dev. 1994 Dec 15;8(24):2964-73 [7528156] J Cell Biol. 1995 Jan;128(1-2):157-69 [7529766] Nature. 1980 Jan 17;283(5744):249-256 [7188712] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The combined effects of chronic ethanol/desipramine treatment on beta-adrenoceptor density and coupling efficiency in rat brain. AN - 69126043; 9881595 AB - Both ethanol and desipramine influence beta-adrenoceptor regulation. We reported previously that ethanol partially counteracted desipramine's effects on beta-adrenoceptor. Previous studies utilized beta-adrenoceptor radioligands that also bind to 5-HT1B receptors, thus, changes in 5-HT1B receptors could have confounded the results. The effects of chronic ethanol, desipramine and ethanol/desipramine treatment on beta-adrenoceptor coupling efficiency to Gs protein in rat brain were examined using 125I-iodocyanopindolol after blocking binding to 5-HT1B receptors. In the frontal cortex, ethanol uncoupled beta-adrenoceptor from GS. Desipramine decreased beta-adrenoceptor density, particularly in the high-conformational state, with no effect on coupling. In combined treatment, desipramine prevented ethanol-induced uncoupling. In the hippocampus, desipramine enhanced beta-adrenoceptor coupling, but ethanol had no effect. In combination with desipramine, ethanol enhanced desipramine-induced decrease in beta-adrenoceptor density in the high-conformational state, but uncoupled beta-adrenoceptors, an effect not observed with ethanol alone. These results suggest a complex interplay between ethanol and antidepressants in modulating beta-adrenoceptor function. JF - European journal of pharmacology AU - Gurguis, G N AU - Turkka, J AU - Karanian, J AU - Linnoila, M AD - Department of Veterans Affairs Medical Center, Dallas, TX 75216, USA. gurguis.george@dallas.va.gov Y1 - 1998/12/18/ PY - 1998 DA - 1998 Dec 18 SP - 241 EP - 251 VL - 363 IS - 2-3 SN - 0014-2999, 0014-2999 KW - Adrenergic Uptake Inhibitors KW - 0 KW - Adrenergic beta-Agonists KW - Adrenergic beta-Antagonists KW - Central Nervous System Depressants KW - Receptors, Adrenergic, beta KW - Ethanol KW - 3K9958V90M KW - Iodocyanopindolol KW - 83498-72-0 KW - Isoproterenol KW - L628TT009W KW - Desipramine KW - TG537D343B KW - Index Medicus KW - Animals KW - Cerebral Cortex -- drug effects KW - Drug Interactions KW - Cerebral Cortex -- metabolism KW - Hippocampus -- metabolism KW - Isoproterenol -- pharmacology KW - Hippocampus -- drug effects KW - Rats KW - Iodocyanopindolol -- pharmacology KW - Rats, Sprague-Dawley KW - Adrenergic beta-Agonists -- pharmacology KW - Binding, Competitive KW - Adrenergic beta-Antagonists -- pharmacology KW - Male KW - Receptors, Adrenergic, beta -- metabolism KW - Central Nervous System Depressants -- pharmacology KW - Desipramine -- pharmacology KW - Ethanol -- pharmacology KW - Adrenergic Uptake Inhibitors -- pharmacology KW - Brain -- drug effects KW - Receptors, Adrenergic, beta -- drug effects KW - Brain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69126043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=The+combined+effects+of+chronic+ethanol%2Fdesipramine+treatment+on+beta-adrenoceptor+density+and+coupling+efficiency+in+rat+brain.&rft.au=Gurguis%2C+G+N%3BTurkka%2C+J%3BKaranian%2C+J%3BLinnoila%2C+M&rft.aulast=Gurguis&rft.aufirst=G&rft.date=1998-12-18&rft.volume=363&rft.issue=2-3&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-03-25 N1 - Date created - 1999-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanism of the synergistic induction of CYP2H by isopentanol plus ethanol: comparison to glutethimide and relation to induction of 5-aminolevulinate synthase. AN - 70111734; 9851836 AB - We had previously found that combined treatment with isopentanol and ethanol synergistically induced CYP2H protein and activity in cultured chick nepatoytes. Here we investigated the mechanism of induction of CYP2H by the alcohols and whether they caused a coordinate induction of 5-aminolevulinate synthase (ALAS) mRNA. Treatment with isopentanol alone or in combination with ethanol resulted in coordinate increases in CYP2H1 and ALAS mRNAs. With isopentanol alone, the amounts of CYP2H1 and ALAS mRNAs at 4 to 6 h were similar to those observed after treatment with the alcohol combination, but declined by 11 h. Readdition of isopentanol at 11 h again increased the expression of both mRNAs, indicating that the decreases at 11 h were due to limiting amounts of inducer. Similar results were observed in cells exposed to low concentrations of glutethimide. In the combined alcohol treatment, increases in CYP2H1 and ALAS mRNAs were sustained from 4 h to 11 h after addition of the alcohols, but decreased to control levels by 24 h. Using pulse labeling to measure de novo synthesis of CYP2H1/2 protein, we found that the increases in CYP2H1/2 protein reflected the increases in CYP2H1 mRNA. The half-life of CYP2H1/2 protein, measured from pulse-chase experiments, was approximately twofold greater than the half-life of CYP2H1 mRNA. Our results indicate that the alcohols and glutethimide coordinately increase ALAS and CYP2H1 mRNA, and that increases in CYP2H1/2 protein arise from increases in its mRNA. Copyright 1998 Academic Press. JF - Archives of biochemistry and biophysics AU - Louis, C A AU - Wood, S G AU - Walton, H S AU - Sinclair, P R AU - Sinclair, J F AD - Veterans Administration Medical Center, White River Junction, Vermont, 05009, USA. Y1 - 1998/12/15/ PY - 1998 DA - 1998 Dec 15 SP - 239 EP - 247 VL - 360 IS - 2 SN - 0003-9861, 0003-9861 KW - Pentanols KW - 0 KW - Ethanol KW - 3K9958V90M KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Glutethimide KW - C8I4BVN78E KW - isopentyl alcohol KW - DEM9NIT1J4 KW - 5-Aminolevulinate Synthetase KW - EC 2.3.1.37 KW - Index Medicus KW - Protein Biosynthesis -- drug effects KW - Animals KW - Liver -- enzymology KW - Liver -- cytology KW - Half-Life KW - Enzyme Induction -- drug effects KW - Liver -- drug effects KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Chick Embryo KW - Enzyme Stability -- drug effects KW - Drug Synergism KW - Time Factors KW - Pentanols -- pharmacology KW - Glutethimide -- metabolism KW - Glutethimide -- pharmacology KW - Ethanol -- pharmacology KW - Cytochrome P-450 Enzyme System -- genetics KW - 5-Aminolevulinate Synthetase -- biosynthesis KW - Cytochrome P-450 Enzyme System -- biosynthesis KW - 5-Aminolevulinate Synthetase -- genetics KW - Pentanols -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70111734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+biochemistry+and+biophysics&rft.atitle=Mechanism+of+the+synergistic+induction+of+CYP2H+by+isopentanol+plus+ethanol%3A+comparison+to+glutethimide+and+relation+to+induction+of+5-aminolevulinate+synthase.&rft.au=Louis%2C+C+A%3BWood%2C+S+G%3BWalton%2C+H+S%3BSinclair%2C+P+R%3BSinclair%2C+J+F&rft.aulast=Louis&rft.aufirst=C&rft.date=1998-12-15&rft.volume=360&rft.issue=2&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Archives+of+biochemistry+and+biophysics&rft.issn=00039861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-01-20 N1 - Date created - 1999-01-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lateral asymmetries of pupillary responses. AN - 85418756; pmid-9872377 AB - We wanted to learn if pupillary changes induced by looking and attending to stimuli on the right and left are asymmetrical. In humans, there are hemispheric asymmetries in the control of attention-arousal systems. Because attention and arousal may influence pupil size, asymmetric pupillary responses may be seen when looking and attending in different directions. Twelve right-handed, healthy volunteers served as subjects. Using infrared pupillography, we recorded changes of pupillary diameter while subjects were looking and attending to the stimuli on the right and left sides of space. For the one second following a saccade, there are three phasic pupillary responses, an initial constriction (C1) then a dilation (D1), followed by constriction (C2). Evaluation of these three responses revealed right-left asymmetries with more pupil dilation (D1) when looking to the stimulus on the right. Our results suggest that subjects are more aroused when looking to the right than when looking to the left. JF - Cortex; a journal devoted to the study of the nervous system and behavior AU - Kim, M AU - Barrett, A M AU - Heilman, K M AD - Department of Neurology, University of Florida College of Medicine, Veterans Administration Medical Center, Gainesville, USA. Y1 - 1998/12// PY - 1998 DA - December 1998 SP - 753 EP - 762 VL - 34 IS - 5 SN - 0010-9452, 0010-9452 KW - Index Medicus KW - National Library of Medicine KW - Photic Stimulation KW - Humans KW - Adult KW - Cues KW - Arousal -- physiology KW - Pattern Recognition, Visual -- physiology KW - Reaction Time -- physiology KW - Female KW - Fixation, Ocular -- physiology KW - Male KW - Reflex, Pupillary -- physiology KW - Functional Laterality -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85418756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.atitle=Lateral+asymmetries+of+pupillary+responses.&rft.au=Kim%2C+M%3BBarrett%2C+A+M%3BHeilman%2C+K+M&rft.aulast=Kim&rft.aufirst=M&rft.date=1998-12-01&rft.volume=34&rft.issue=5&rft.spage=753&rft.isbn=&rft.btitle=&rft.title=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.issn=00109452&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Inhibition of cell proliferation in head and neck squamous cell carcinoma cell lines with antisense cyclin D1. AN - 85415170; pmid-9852531 AB - Cyclin D1 and cyclin G are essential regulatory factors in the progression of the cell cycle from G0 through G1 and S phase. Aberrations in expression of these cyclins may lead to dysregulated cellular proliferation that could result in neoplasia. Amplification and overexpression of cyclin D1 have been observed in many human cancers, whereas cyclin G is a new cyclin recently described in osteosarcoma cells. This study was performed to determine whether these cyclins were amplified in head and neck squamous cell carcinoma (HNSCC) tumors. Polymerase chain reaction of DNA extracted from 22 HNSCC primary tumors and three HNSCC cell lines did not reveal amplification of cyclin D1 in any of the tumor samples. Southern blot analysis identified amplification of cyclin D1 in a single tumor. Amplification of cyclin G was not observed in any of the tumors by Southern blot hybridization with a cyclin G probe. HNSCC cell lines transfected with antisense cyclin D1 were tested for cell proliferation by the incorporation of 3H-thymidine into cells grown in serum-free media. By 72 hours of incubation, there was a greater than 30% reduction in proliferation of cells transfected with antisense cyclin D1 as compared with non-transfected control cells. The results indicate that cyclin D1 may play an important role in the growth and proliferation of HNSCC cells. JF - Otolaryngology and head and neck surgery AU - Wang, M B AU - Billings, K R AU - Venkatesan, N AU - Hall, F L AU - Srivatsan, E S AD - Division of Head and Neck Surgery, UCLA School of Medicine, West Los Angeles Veterans Administration Medical Center, USA. Y1 - 1998/12// PY - 1998 DA - December 1998 SP - 593 EP - 599 VL - 119 IS - 6 SN - 0194-5998, 0194-5998 KW - Index Medicus KW - National Library of Medicine KW - Polymerase Chain Reaction KW - Blotting, Western KW - Tumor Cells, Cultured KW - Neoplasm Staging KW - Blotting, Southern KW - Humans KW - Adult KW - Cell Division -- physiology KW - Aged KW - Middle Aged KW - DNA, Neoplasm -- analysis KW - Male KW - Female KW - Cyclin D1 -- metabolism KW - Carcinoma, Squamous Cell -- pathology KW - Head and Neck Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85415170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology+and+head+and+neck+surgery&rft.atitle=Inhibition+of+cell+proliferation+in+head+and+neck+squamous+cell+carcinoma+cell+lines+with+antisense+cyclin+D1.&rft.au=Wang%2C+M+B%3BBillings%2C+K+R%3BVenkatesan%2C+N%3BHall%2C+F+L%3BSrivatsan%2C+E+S&rft.aulast=Wang&rft.aufirst=M&rft.date=1998-12-01&rft.volume=119&rft.issue=6&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Otolaryngology+and+head+and+neck+surgery&rft.issn=01945998&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Heparin-induced skin necrosis: nurses beware. AN - 79614649; 10670317 AB - As the prophylactic use of heparin continues to increase, nurses must be aware that heparin use may cause heparin-induced skin necrosis--a rare but serious complication. Although even more severe complications may occur from heparin use, this discussion will focus on skin necrosis caused by subcutaneous heparin. Should heparin-induced skin necrosis develop, heparin therapy must be discontinued immediately. This case presentation illustrates one patient's reaction to this complication. JF - Dermatology nursing AU - Sanchez, M N AU - Barker, C AU - Brosnan, J AD - West Los Angeles Veterans Administration Medical Center, CA, USA. Y1 - 1998/12// PY - 1998 DA - December 1998 SP - 419 EP - 23, 429 VL - 10 IS - 6 SN - 1060-3441, 1060-3441 KW - Anticoagulants KW - 0 KW - Heparin KW - 9005-49-6 KW - Nursing KW - Causality KW - Patient Education as Topic KW - Necrosis KW - Humans KW - Injections, Subcutaneous KW - Heparin -- administration & dosage KW - Anticoagulants -- adverse effects KW - Skin Diseases -- pathology KW - Skin Diseases -- prevention & control KW - Skin Diseases -- chemically induced KW - Skin Diseases -- nursing KW - Heparin -- adverse effects KW - Anticoagulants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79614649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dermatology+nursing&rft.atitle=Heparin-induced+skin+necrosis%3A+nurses+beware.&rft.au=Sanchez%2C+M+N%3BBarker%2C+C%3BBrosnan%2C+J&rft.aulast=Sanchez&rft.aufirst=M&rft.date=1998-12-01&rft.volume=10&rft.issue=6&rft.spage=419&rft.isbn=&rft.btitle=&rft.title=Dermatology+nursing&rft.issn=10603441&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-02-17 N1 - Date created - 2000-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of phosphorylation sites in the G protein-coupled receptor for parathyroid hormone. Receptor phosphorylation is not required for agonist-induced internalization. AN - 70114934; 9849959 AB - In some G protein-coupled receptors (GPCRs), agonist-dependent phosphorylation by specific GPCR kinases (GRKs) is an important mediator of receptor desensitization and endocytosis. Phosphorylation and the subsequent events that it triggers, such as arrestin binding, have been suggested to be regulatory mechanisms for a wide variety of GPCRs. In the present study, we investigated whether agonist-induced phosphorylation of the PTH receptor, a class II GPCR, also regulates receptor internalization. Upon agonist stimulation, the PTH receptor was exclusively phosphorylated on serine residues. Phosphoamino acid analysis of a number of receptor mutants in which individual serine residues had been replaced by threonine identified serine residues in positions 485, 486, and 489 of the cytoplasmic tail as sites of phosphorylation after agonist treatment. When serine residues at positions 483, 485, 486, 489, 495, and 498 were simultaneously replaced by alanine residues, the PTH receptor was no longer phosphorylated either basally or in response to PTH. The substitution of these serine residues by alanine affected neither the number of receptors expressed on the cell surface nor the ability of the receptor to signal via Gs. Overexpression of GRK2, but not GRK3, enhanced PTH-stimulated receptor phosphorylation, and this phosphorylation was abolished by alanine mutagenesis of residues 483, 485, 486, 489, 495, and 498. Thus, phosphorylation of the PTH receptor by the endogenous kinase in HEK-293 cells occurs on the same residues targeted by overexpressed GRK2. Strikingly, the rate and extent of PTH-stimulated internalization of mutated PTH receptors lacking phosphorylation sites were identical to that observed for the wild-type PTH receptor. Moreover, overexpressed GRK2, while enhancing the phosphorylation of the wild-type PTH receptor, had no affect on the rate or extent of receptor internalization in response to PTH. Thus, the agonist-occupied PTH receptor is phosphorylated by a kinase similar or identical to GRK2 in HEK-293 cells, but this phosphorylation is not requisite for efficient receptor endocytosis. JF - Molecular endocrinology (Baltimore, Md.) AU - Malecz, N AU - Bambino, T AU - Bencsik, M AU - Nissenson, R A AD - Veterans Administration Medical Center and the Department of Medicine, University of California, San Francisco 94121, USA. Y1 - 1998/12// PY - 1998 DA - December 1998 SP - 1846 EP - 1856 VL - 12 IS - 12 SN - 0888-8809, 0888-8809 KW - Arrestin KW - 0 KW - Parathyroid Hormone KW - Receptors, Parathyroid Hormone KW - Phosphoserine KW - 17885-08-4 KW - Receptor Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - ADRBK2 protein, human KW - EC 2.7.11.15 KW - G-Protein-Coupled Receptor Kinase 3 KW - beta-Adrenergic Receptor Kinases KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Index Medicus KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - Animals KW - Arrestin -- metabolism KW - Receptor Protein-Tyrosine Kinases -- genetics KW - Humans KW - Gene Expression KW - Cyclic AMP-Dependent Protein Kinases -- genetics KW - Receptor Protein-Tyrosine Kinases -- metabolism KW - Phosphoserine -- analysis KW - Phosphoserine -- metabolism KW - Binding Sites KW - Mutagenesis, Site-Directed KW - Endocytosis KW - Parathyroid Hormone -- pharmacology KW - Cattle KW - Phosphorylation KW - Immunosorbent Techniques KW - Cell Line KW - Opossums KW - Receptors, Parathyroid Hormone -- genetics KW - Receptors, Parathyroid Hormone -- metabolism KW - Receptors, Parathyroid Hormone -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70114934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Identification+of+phosphorylation+sites+in+the+G+protein-coupled+receptor+for+parathyroid+hormone.+Receptor+phosphorylation+is+not+required+for+agonist-induced+internalization.&rft.au=Malecz%2C+N%3BBambino%2C+T%3BBencsik%2C+M%3BNissenson%2C+R+A&rft.aulast=Malecz&rft.aufirst=N&rft.date=1998-12-01&rft.volume=12&rft.issue=12&rft.spage=1846&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-02-05 N1 - Date created - 1999-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes. AN - 70110699; 9843158 AB - Astroglial swelling occurs in acute hyperammonemic states, including acute hepatic encephalopathy. In these conditions, the peripheral-type benzodiazepine receptor (PBR), a receptor associated with neurosteroidogenesis, is up-regulated. This study examined the potential involvement of PBRs and neurosteroids in ammonia-induced astrocyte swelling in culture. At low micromolar concentrations, the PBR antagonist PK 11195, atrial natriuretic peptide, and protoporhyrin IX, which are known to interact with the PBR, attenuated (16-100%) the effects of ammonia, whereas the PBR agonists Ro5-4864, diazepam binding inhibitor (DBI51-70), and octadecaneuropeptide exacerbated (10-15%) the effects of ammonia. At micromolar concentrations, diazepam, which interacts with both the PBR and the central-type benzodiazepine receptor (CBR), increased swelling by 11%, whereas flumazenil, a CBR antagonist, had no effect. However, at 100 nM diazepam and flumazenil abrogated ammonia-induced swelling. The neurosteroids dehydroepiandrosterone sulfate, tetrahydroprogesterone, pregnenolone sulfate, and tetrahydrodeoxycorticosterone (THDOC), products of PBR stimulation, at micromolar concentrations significantly enhanced (70%) ammonia-induced swelling. However, at nanomolar concentrations, these neurosteroids, with exception of THDOC, blocked ammonia-induced swelling. We conclude that neurosteroids and agents that interact with the PBR influence ammonia-induced swelling. These agents may represent novel therapies for acute hyperammonemic syndromes and other conditions associated with brain edema and astrocyte swelling. JF - Journal of neuroscience research AU - Bender, A S AU - Norenberg, M D AD - Veterans Administration Medical Center, Department of Pathology, University of Miami School of Medicine, Florida 33101, USA. Y1 - 1998/12/01/ PY - 1998 DA - 1998 Dec 01 SP - 673 EP - 680 VL - 54 IS - 5 SN - 0360-4012, 0360-4012 KW - Benzodiazepinones KW - 0 KW - Diazepam Binding Inhibitor KW - GABA-A Receptor Agonists KW - GABA-A Receptor Antagonists KW - Isoquinolines KW - Nerve Tissue Proteins KW - Neuropeptides KW - Peptide Fragments KW - Protoporphyrins KW - Receptors, GABA-A KW - Steroids KW - diazepam binding inhibitor (33-50) KW - diazepam-binding inhibitor (51-70) KW - pregnenolone sulfate KW - 04Y4D91RG0 KW - Benzodiazepines KW - 12794-10-4 KW - 4'-chlorodiazepam KW - 2QW0IK1742 KW - Desoxycorticosterone KW - 40GP35YQ49 KW - Flumazenil KW - 40P7XK9392 KW - tetrahydrodeoxycorticosterone KW - 4AB717DP4A KW - Dehydroepiandrosterone Sulfate KW - 57B09Q7FJR KW - Clonazepam KW - 5PE9FDE8GB KW - Pregnenolone KW - 73R90F7MQ8 KW - Ammonia KW - 7664-41-7 KW - Atrial Natriuretic Factor KW - 85637-73-6 KW - atrial natriuretic factor prohormone (103-126) KW - 97793-28-7 KW - Pregnanolone KW - BXO86P3XXW KW - protoporphyrin IX KW - C2K325S808 KW - Diazepam KW - Q3JTX2Q7TU KW - PK 11195 KW - YNF83VN1RL KW - Index Medicus KW - Pregnenolone -- pharmacology KW - Neuropeptides -- pharmacology KW - Protoporphyrins -- pharmacology KW - Diazepam -- pharmacology KW - Atrial Natriuretic Factor -- pharmacology KW - Pregnanolone -- pharmacology KW - Clonazepam -- pharmacology KW - Flumazenil -- pharmacology KW - Cell Size -- drug effects KW - Desoxycorticosterone -- analogs & derivatives KW - Isoquinolines -- pharmacology KW - Dehydroepiandrosterone Sulfate -- pharmacology KW - Brain Edema -- chemically induced KW - Up-Regulation -- drug effects KW - Peptide Fragments -- pharmacology KW - Desoxycorticosterone -- pharmacology KW - Benzodiazepinones -- pharmacology KW - Brain Edema -- prevention & control KW - Nerve Tissue Proteins -- physiology KW - Ammonia -- pharmacology KW - Receptors, GABA-A -- physiology KW - Nerve Tissue Proteins -- agonists KW - Astrocytes -- ultrastructure KW - Astrocytes -- drug effects KW - Receptors, GABA-A -- biosynthesis KW - Steroids -- pharmacology KW - Nerve Tissue Proteins -- biosynthesis KW - Nerve Tissue Proteins -- antagonists & inhibitors KW - Benzodiazepines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70110699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+research&rft.atitle=Effect+of+benzodiazepines+and+neurosteroids+on+ammonia-induced+swelling+in+cultured+astrocytes.&rft.au=Bender%2C+A+S%3BNorenberg%2C+M+D&rft.aulast=Bender&rft.aufirst=A&rft.date=1998-12-01&rft.volume=54&rft.issue=5&rft.spage=673&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+research&rft.issn=03604012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-03-11 N1 - Date created - 1999-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acupuncture: a review of its history, theories, and indications. AN - 70108388; 9853723 AB - The National Institutes of Health recently recommended acupuncture as an effective tool for the treatment of various health problems. Acupuncture is an old technique but has been popular in the United States only since 1972. Its history, theories, and indications are not well known to the medical community. We reviewed the literature to gather information on the history, techniques, physiology, indications, adverse effects, and opposing views to acupuncture. The mechanism by which acupuncture works involves neurotransmitters and adrenocorticotropic hormones. It appears to be effective in the treatment of pain, nausea, and drug detoxification and in stroke victims. Studies suggest acupuncture is no more effective than placebo. Acupuncture side effects have rarely been reported. Acupuncture appears to be a safe and effective alternative medical therapy for certain health problems. More controlled research is necessary to better understand the range of its clinical application. JF - Southern medical journal AU - Ceniceros, S AU - Brown, G R AD - Department of Psychiatry, East Tennessee State University, James H. Quillen College of Medicine, and James H. Quillen Veterans Administration Medical Center, Johnson City 37614, USA. Y1 - 1998/12// PY - 1998 DA - December 1998 SP - 1121 EP - 1125 VL - 91 IS - 12 SN - 0038-4348, 0038-4348 KW - Adrenal Cortex Hormones KW - 0 KW - Neurotransmitter Agents KW - Placebos KW - Abridged Index Medicus KW - Index Medicus KW - History of medicine KW - United States KW - Pain Management KW - Inactivation, Metabolic KW - History, 20th Century KW - Neurotransmitter Agents -- physiology KW - Nausea -- therapy KW - Humans KW - National Institutes of Health (U.S.) KW - History, Ancient KW - Cerebrovascular Disorders -- therapy KW - Adrenal Cortex Hormones -- physiology KW - Acupuncture Therapy -- history KW - Acupuncture Therapy -- methods KW - Acupuncture Therapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70108388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Acupuncture%3A+a+review+of+its+history%2C+theories%2C+and+indications.&rft.au=Ceniceros%2C+S%3BBrown%2C+G+R&rft.aulast=Ceniceros&rft.aufirst=S&rft.date=1998-12-01&rft.volume=91&rft.issue=12&rft.spage=1121&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-12-23 N1 - Date created - 1998-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Images in psychiatry. Marie Nyswander, 1919-1986. AN - 70100259; 9842790 JF - The American journal of psychiatry AU - Kosten, T R AD - VA Connecticut Healthcare System, Department of Psychiatry, West Haven, CT 06516, USA. Kosten.Thomas_R@West-Haven.VA.Gov Y1 - 1998/12// PY - 1998 DA - December 1998 SP - 1766 VL - 155 IS - 12 SN - 0002-953X, 0002-953X KW - Methadone KW - UC6VBE7V1Z KW - Abridged Index Medicus KW - Index Medicus KW - History of medicine KW - Nyswander KW - United States KW - History, 20th Century KW - Humans KW - Female KW - Methadone -- history KW - Heroin Dependence -- history KW - Psychiatry -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70100259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Images+in+psychiatry.+Marie+Nyswander%2C+1919-1986.&rft.au=Kosten%2C+T+R&rft.aulast=Kosten&rft.aufirst=T&rft.date=1998-12-01&rft.volume=155&rft.issue=12&rft.spage=1766&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-12-15 N1 - Date created - 1998-12-15 N1 - Date revised - 2017-01-13 N1 - People - Nyswander N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Nyswander ER - TY - JOUR T1 - Comorbidity and course of psychiatric disorders in a community sample of former prisoners of war. AN - 70091501; 9842785 AB - The authors assessed DSM-III-R disorders among American former prisoners of war. Comorbidity, time of onset, and the relationship of trauma severity to complicated versus uncomplicated posttraumatic stress disorder (PTSD) were examined. A community sample (N=262) of men exposed to combat and imprisonment was assessed by clinicians using the Structured Clinical Interview for DSM-III-R. The rates of comorbidity among the men with PTSD were lower than rates from community samples assessed by lay interviewers. Over one-third of the cases of lifetime PTSD were uncomplicated by another axis I disorder; over one-half of the cases of current PTSD were uncomplicated. PTSD almost always emerged soon after exposure to trauma. Lifetime PTSD was associated with increased risk of lifetime panic disorder, major depression, alcohol abuse/dependence, and social phobia. Current PTSD was associated with increased risk of current panic disorder, dysthymia, social phobia, major depression, and generalized anxiety disorder. Relative to PTSD, the onset of the comorbid disorders was as follows: major depression, predominantly secondary; alcohol abuse/dependence and agoraphobia, predominantly concurrent (same year); social phobia, equal proportions primary and concurrent; and panic disorder, equal proportions concurrent and secondary. Trauma exposure was comparable in the subjects with complicated and uncomplicated PTSD. The types of comorbid diagnoses and their patterns of onset were comparable to the diagnoses and patterns observed in other community samples. The findings support the validity of the PTSD construct; PTSD can be distinguished from comorbid disorders. Uncomplicated PTSD may be more common than previous studies suggest, particularly in clinician-assessed subjects exposed to severe trauma. JF - The American journal of psychiatry AU - Engdahl, B AU - Dikel, T N AU - Eberly, R AU - Blank, A AD - Psychology Service, VA Medical Center, Minneapolis, MN 55417, USA. engdahl.brian@minneapolis.va.gov Y1 - 1998/12// PY - 1998 DA - December 1998 SP - 1740 EP - 1745 VL - 155 IS - 12 SN - 0002-953X, 0002-953X KW - Abridged Index Medicus KW - Index Medicus KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Agoraphobia -- diagnosis KW - Reproducibility of Results KW - Alcoholism -- diagnosis KW - Humans KW - Comorbidity KW - Dysthymic Disorder -- epidemiology KW - Depressive Disorder -- epidemiology KW - Dysthymic Disorder -- diagnosis KW - Panic Disorder -- epidemiology KW - Alcoholism -- epidemiology KW - Life Change Events KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Depressive Disorder -- diagnosis KW - Agoraphobia -- epidemiology KW - Psychiatric Status Rating Scales -- statistics & numerical data KW - Male KW - Prevalence KW - Panic Disorder -- diagnosis KW - Warfare KW - Mental Disorders -- diagnosis KW - Mental Disorders -- epidemiology KW - Prisoners -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70091501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Comorbidity+and+course+of+psychiatric+disorders+in+a+community+sample+of+former+prisoners+of+war.&rft.au=Engdahl%2C+B%3BDikel%2C+T+N%3BEberly%2C+R%3BBlank%2C+A&rft.aulast=Engdahl&rft.aufirst=B&rft.date=1998-12-01&rft.volume=155&rft.issue=12&rft.spage=1740&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-12-15 N1 - Date created - 1998-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Monoclonal and polyclonal antibodies recognizing acetaldehyde-protein adducts. AN - 70076854; 9827586 AB - Studies have investigated the hypothesis that metabolically derived acetaldehyde (AA) is capable of complexing with liver cell proteins to form AA-protein adducts that are capable of acting as antigens and inducing an immune response, as detected by the formation of unique antibodies. In an effort to better characterize and describe these adducts, mouse monoclonal and rabbit polyclonal antibodies specific for antigens prepared with AA under non-reducing (physiologic) and reducing (presence of sodium cyanoborohydride) conditions have been prepared. Two monoclonal antibodies were developed. The first antibody was RT1.1, which is specific to N-ethyl lysine (NEL); it is of the IgG2b isotype and recognizes all proteins modified with AA under reducing conditions. The other monoclonal antibody, NR-1, was of the IgG3 isotype; it recognizes proteins modified with AA under non-reducing conditions and cannot be inhibited by NEL. Affinity-purified and/or absorbed polyclonal antibodies were also produced to these epitopes. Using this panel of monoclonal and affinity-purified polyclonal antibodies, unique antigen-antibody binding occurred that: (1) detected only NEL; (2) reacted with the alpha-amino group on proteins prepared under reducing conditions; and (3) detected adducts on proteins prepared under non-reducing conditions. However, the only antibodies that recognized antigen(s) from alcohol-fed rat livers were those that were not specific to NEL or the alpha-amino group modified under reducing conditions. These data indicate that the relevant adduct in alcohol-fed rat livers is not NEL, and that it presumably is related to proteins modified with AA under non-reducing conditions. JF - Biochemical pharmacology AU - Thiele, G M AU - Tuma, D J AU - Miller, J A AU - Wegter, K M AU - McDonald, T L AU - Klassen, L W AD - Veterans Administration Alcohol Research Center, Omaha Veterans Administration Medical Center, NE 68105, USA. lthiele@juno.com Y1 - 1998/12/01/ PY - 1998 DA - 1998 Dec 01 SP - 1515 EP - 1523 VL - 56 IS - 11 SN - 0006-2952, 0006-2952 KW - Antibodies KW - 0 KW - Antibodies, Monoclonal KW - Antigens KW - Proteins KW - Acetaldehyde KW - GO1N1ZPR3B KW - Lysine KW - K3Z4F929H6 KW - Index Medicus KW - Animals KW - Cytosol -- metabolism KW - Alcoholism -- metabolism KW - Mice KW - Rabbits KW - Mice, Inbred BALB C KW - Antigens -- analysis KW - Rats KW - Antibody Specificity KW - Rats, Sprague-Dawley KW - Liver -- metabolism KW - Acetaldehyde -- metabolism KW - Acetaldehyde -- analysis KW - Proteins -- metabolism KW - Proteins -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70076854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Monoclonal+and+polyclonal+antibodies+recognizing+acetaldehyde-protein+adducts.&rft.au=Thiele%2C+G+M%3BTuma%2C+D+J%3BMiller%2C+J+A%3BWegter%2C+K+M%3BMcDonald%2C+T+L%3BKlassen%2C+L+W&rft.aulast=Thiele&rft.aufirst=G&rft.date=1998-12-01&rft.volume=56&rft.issue=11&rft.spage=1515&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-12-07 N1 - Date created - 1998-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol abuse, alcoholism, and damage to the immune system--a review. AN - 69133245; 9884135 AB - Chronic alcohol abuse exacts a major social and medical toll in the United States and other Western countries. One of the least appreciated medical complications of alcohol abuse is altered immune regulation leading to immunodeficiency and autoimmunity. The consequences of the immunodeficiency include increased susceptibility to bacterial pneumonia, tuberculosis, and other infectious diseases. In addition, the chronic alcoholic often has circulating autoantibodies, and recent investigations indicate that the most destructive complications of alcoholism, such as liver disease and liver failure, may have a component of autoimmunity. Current research on altered cytokine balance produced by alcohol is leading to new insights on the regulation of the immune system in the chronic alcoholic. There is also recent development of exciting new techniques designed to improve or restore immune function by manipulation of cytokine balance. Although much remains to be learned, both in the abnormalities produced by alcohol and in the techniques to reverse those abnormalities, current progress reflects a rapidly improving understanding of the basic immune disorders of the alcoholic. JF - Alcoholism, clinical and experimental research AU - Cook, R T AD - Department of Pathology, Veterans Administration Medical Center, and the University of Iowa, Iowa City 52246, USA. Y1 - 1998/12// PY - 1998 DA - December 1998 SP - 1927 EP - 1942 VL - 22 IS - 9 SN - 0145-6008, 0145-6008 KW - Cytokines KW - 0 KW - Index Medicus KW - Immune Tolerance -- drug effects KW - Animals KW - Humans KW - Immunity, Cellular -- drug effects KW - Immune Tolerance -- immunology KW - Immunity, Cellular -- immunology KW - Cytokines -- blood KW - Alcoholism -- immunology KW - Alcohol-Related Disorders -- immunology KW - Autoimmune Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69133245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Alcohol+abuse%2C+alcoholism%2C+and+damage+to+the+immune+system--a+review.&rft.au=Cook%2C+R+T&rft.aulast=Cook&rft.aufirst=R&rft.date=1998-12-01&rft.volume=22&rft.issue=9&rft.spage=1927&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-03-29 N1 - Date created - 1999-03-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment of Multiple Sclerosis with the Interferon-betas: Comparative Risks and Benefits AN - 19375872; 7478526 AB - Several inteferons (IFNs) have recently been introduced for the treatment of multiple sclerosis (MS). These are IFNbeta-1b (Betaseron) and 2 IFNbeta-1a preparations (Avonex and Rebif). All 3 drugs reduce the number of acute exacerbations in relapsing remitting MS by about one-third but, because of differences in the trials and trial design, direct comparison of efficacy is difficult. Only the IFNbeta-1a preparations have been demonstrated to have an effect in slowing disability. Possible reasons for disparate results with the 3 IFNbetas include substantial differences in trial design, antigenicity, route of administration and bioavailability. Adverse effects differ among the various preparations. Avonex, which is given intramuscularly once weekly, has the fewest adverse effects and the lowest incidence of neutralising antibody formation at 5 to 7%. IFNbeta-1b has the highest incidence at 30 to 39%, and Rebif is intermediate at 13 to 24%. Additionally, IFNbeta-1b and Rebif often cause significant skin reactions, and the former causes occasional skin necrosis at injection sites, a problem not seen with Avonex. On the basis of the available information, the IFNbeta-1a preparations are preferred in terms of tolerability, effects on exacerbation rate and disability, less frequent antibody formation and convenience. The available preparations, Avonex and Rebif, have shown similar effectiveness although dose, route of administration and dosage regimens differ. The administered dose of IFNbeta-1b and Rebif appears to be somewhat higher than that of Avonex, but the differences in effect are small. Further information regarding the effect of different doses and dosage regimens with the various preparations is expected to become available over the next few years. JF - BioDrugs AU - Herndon, R M AD - G.V. (Sonny) Montgomery Veterans Administration Medical Center, Jackson, and the University of Mississippi Medical Center, Jackson, Mississippi, USA Y1 - 1998/12/01/ PY - 1998 DA - 1998 Dec 01 SP - 463 EP - 470 PB - Adis International Ltd., 41 Centorian Drive Private Bay 65901, Mairangi Bay Auckland 10 New Zealand, [mailto:sportsmed@adis.co.nz], [URL:http://www.adis.com] VL - 10 IS - 6 SN - 1173-8804, 1173-8804 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Reviews-on-treatment KW - Multiple-sclerosis, treatment KW - Interferon-beta-1B-Chiron-Schering, therapeutic-us KW - Research-and-development KW - Interferon-beta-1A-Serono, therapeutic-use KW - Interferon-beta-1A, therapeutic-use KW - Biotechnology KW - Neuroprotectants, therapeutic-use KW - Cost-benefit analysis KW - beta -Interferon KW - Interferon KW - Bioavailability KW - Antibodies KW - Necrosis KW - Skin KW - Multiple sclerosis KW - Antigenicity KW - Drug development KW - Side effects KW - F 06955:Immunomodulation & Immunopharmacology KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19375872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioDrugs&rft.atitle=Treatment+of+Multiple+Sclerosis+with+the+Interferon-betas%3A+Comparative+Risks+and+Benefits&rft.au=Herndon%2C+R+M&rft.aulast=Herndon&rft.aufirst=R&rft.date=1998-12-01&rft.volume=10&rft.issue=6&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=BioDrugs&rft.issn=11738804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - beta -Interferon; Cost-benefit analysis; Bioavailability; Interferon; Necrosis; Antibodies; Skin; Antigenicity; Multiple sclerosis; Drug development; Side effects ER - TY - JOUR T1 - Antibacterial effects of levofloxacin, erythromycin, and rifampin in a human monocyte system against Legionella pneumophila AN - 17126310; 4430662 AB - The antibacterial activities of levofloxacin, erythromycin, and rifampin against intracellular Legionella pneumophila L-1033, serogroup 1, were studied. In an in vitro system utilizing adherent human monocytes, L. pneumophila L-1033, a phagocytosis time period of 1 h, and antibiotic (levofloxacin, erythromycin, and/or rifampin) at 1 to 10 times the MIC, the CFU/ml values for the monocyte lysate were determined during 0- to 4-day time periods. The decrease in CFU/ml with levofloxacin at pH 7.4 was rapid, occurring within 24 h, and was drug concentration dependent (P < 0.01). The decrease in CFU with rifampin was first observed at 48 h (P < 0.01), while only a minimal decrease in CFU/ml was observed with erythromycin. Combination of levofloxacin and rifampin and of levofloxacin and erythromycin at ten times their MICs significantly decreased the CFU/ml value (P < 0.01), to the value attained by levofloxacin alone, while combination of rifampin and erythromycin did not. Removal of levofloxacin after 24 h of incubation resulted in regrowth of L. pneumophila L-1033, while a continued slow decrease in CFU/ml was seen following rifampin removal; CFU/ml values were unaffected by the removal of erythromycin. At 4 days, and even in assays performed following antibiotic removal, the CFU/ml value continued to be lower in the levofloxacin and rifampin assays than in the assays with erythromycin. Levofloxacin had a significantly higher bactericidal activity against L. pneumophila L-1033 than erythromycin or rifampin. In these assays, the addition of erythromycin or rifampin did not affect the antibacterial activity of levofloxacin. JF - Antimicrobial Agents & Chemotherapy AU - Baltch, AL AU - Smith, R P AU - Franke, MA AU - Michelsen, P B AD - Infectious Diseases (111D), Stratton VA Medical Center, 113 Holland Ave., Albany, NY 12208, USA, baltch.aldona@albany.va.gov Y1 - 1998/12// PY - 1998 DA - Dec 1998 SP - 3153 EP - 3156 VL - 42 IS - 12 SN - 0066-4804, 0066-4804 KW - erythromycin KW - levofloxacin KW - rifampin KW - Microbiology Abstracts B: Bacteriology KW - Legionella pneumophila KW - Antibiotics KW - Monocytes KW - Antibacterial agents KW - J 02806:Quinones, quinolones and quinolines KW - J 02783:Antibiotics: General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17126310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Antibacterial+effects+of+levofloxacin%2C+erythromycin%2C+and+rifampin+in+a+human+monocyte+system+against+Legionella+pneumophila&rft.au=Baltch%2C+AL%3BSmith%2C+R+P%3BFranke%2C+MA%3BMichelsen%2C+P+B&rft.aulast=Baltch&rft.aufirst=AL&rft.date=1998-12-01&rft.volume=42&rft.issue=12&rft.spage=3153&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Legionella pneumophila; Antibacterial agents; Antibiotics; Monocytes ER - TY - JOUR T1 - In vitro activities of several diaminomethylpyridopyrimidines against Mycobacterium avium complex AN - 17122765; 4430684 AB - Three recently synthesized dihydrofolate reductase (DHFR) inhibitors designated SoRI 8890, 8895, and 8897 were evaluated for their in vitro activities against 25 isolates of Mycobacterium avium complex. The MICs at which 50 and 90% of isolates were inhibited were 1 and 2, 4 and 8, and 4 and 8 mu g/ml for SoRI 8890, 8895, and 8897, respectively. Although the addition of dapsone at 0.5 mu g/ml did not significantly enhance the in vitro activities of these compounds, their activities alone were comparable to, if not better than, results seen with other DHFR inhibitors, such as pyrimethamine or WR99210. JF - Antimicrobial Agents & Chemotherapy AU - Shoen, C M AU - Choromanska, O AU - Reynolds, R C AU - Piper, J R AU - Johnson, CA AU - Cynamon, M H AD - VAMC, 800 Irving Ave., Syracuse, NY 13210, USA, Cynamon.Michael@syracuse.VA.Gov Y1 - 1998/12// PY - 1998 DA - Dec 1998 SP - 3315 EP - 3316 VL - 42 IS - 12 SN - 0066-4804, 0066-4804 KW - diaminomethylpyridopyrimidine KW - diaminomethylpyridopyrimidines KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Antimycobacterial agents KW - Mycobacterium avium KW - Antibacterial agents KW - A 01065:Antimycobacterial KW - J 02812:Antibacterial Agents: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17122765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+vitro+activities+of+several+diaminomethylpyridopyrimidines+against+Mycobacterium+avium+complex&rft.au=Shoen%2C+C+M%3BChoromanska%2C+O%3BReynolds%2C+R+C%3BPiper%2C+J+R%3BJohnson%2C+CA%3BCynamon%2C+M+H&rft.aulast=Shoen&rft.aufirst=C&rft.date=1998-12-01&rft.volume=42&rft.issue=12&rft.spage=3315&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium avium; Antimycobacterial agents; Antibacterial agents ER - TY - JOUR T1 - In situ hybridization analysis of immunoglobulin heavy chain variable gene expression with family specific oligonucleotide probes AN - 16518331; 4412674 AB - We have developed an improved in situ hybridization (ISH) technique for the analysis of human immunoglobulin heavy chain variable (V sub(H)) gene family expression in suspensions of human B lymphocytes. Oligonucleotide probes specific for framework region (FR) consensus germline sequences for each of the seven human V sub(H) gene families were designed and hybridization conditions were developed to accommodate the greatest degree of V sub(H) gene variation, maximize the sensitivity of transcript detection, and assure the specificity of the technique. The hybridization parameters were rigorously characterized by Southern hybridization to a panel of 30 V sub(H) cDNA clones and by ISH to 17 B cell lines expressing characterized V sub(H) genes. Results obtained with ISH using V sub(H) gene family and isotype-specific gene probes correlated well with histochemical measures of Ig gene product expression. Profiles of cellular V sub(H) gene expression were generated for mitogen stimulated peripheral blood B lymphocytes from six normal subjects. When compared with estimates of frequency of V sub(H) genes in the human germline, the results were consistent with a random pattern of V sub(H) family utilization. JF - Journal of Immunological Methods AU - Rundle, CH AU - Schroeder, HW Jr AU - Koopman, W J AD - The Birmingham Veterans Administration Medical Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA Y1 - 1998/11/13/ PY - 1998 DA - 1998 Nov 13 SP - 31 EP - 52 PB - Elsevier Science B.V. VL - 218 IS - 1-2 SN - 0022-1759, 0022-1759 KW - heavy chains KW - in situ hybridization KW - oligonucleotides KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - F 06713:Physicochemical methods KW - W3 33243:Molecular methods KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16518331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=In+situ+hybridization+analysis+of+immunoglobulin+heavy+chain+variable+gene+expression+with+family+specific+oligonucleotide+probes&rft.au=Rundle%2C+CH%3BSchroeder%2C+HW+Jr%3BKoopman%2C+W+J&rft.aulast=Rundle&rft.aufirst=CH&rft.date=1998-11-13&rft.volume=218&rft.issue=1-2&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Clozapine effects on force control in schizophrenic patients. AN - 70061767; 9824875 AB - We previously reported significant differences in force control (FC) function between schizophrenics treated with typical antipsychotic drugs (APD) and those treated with clozapine. Clozapine treatment was associated with an attenuation of the capacity for fine motor control. We now report that a test-retest study with 41 treatment-refractory patients confirms our earlier finding; the FC deficit is due primarily to clozapine treatment. An additional comparison was made with 10 patients who were administered the FC test repeatedly through the initial clozapine titration interval of 6-8 weeks. The results suggest that two distinct clozapine effects can be distinguished, an initial transient stage characterized by 'drowsiness' and a subsequent stage with dose-dependent emerging myoclonic features. JF - Schizophrenia research AU - Vrtunski, P B AU - Konicki, P E AU - Jaskiw, G E AU - Brescan, D W AU - Kwon, K Y AU - Jurjus, G AD - Cleveland VA Medical Center, Brecksville, OH 44141, USA. vrtunski.p_bart@cleveland.va.gov Y1 - 1998/11/09/ PY - 1998 DA - 1998 Nov 09 SP - 39 EP - 48 VL - 34 IS - 1-2 SN - 0920-9964, 0920-9964 KW - Antipsychotic Agents KW - 0 KW - Clozapine KW - J60AR2IKIC KW - Index Medicus KW - Analysis of Variance KW - Epilepsies, Myoclonic -- chemically induced KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Male KW - Female KW - Psychomotor Performance -- drug effects KW - Schizophrenia -- drug therapy KW - Clozapine -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Schizophrenia -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70061767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+research&rft.atitle=Clozapine+effects+on+force+control+in+schizophrenic+patients.&rft.au=Vrtunski%2C+P+B%3BKonicki%2C+P+E%3BJaskiw%2C+G+E%3BBrescan%2C+D+W%3BKwon%2C+K+Y%3BJurjus%2C+G&rft.aulast=Vrtunski&rft.aufirst=P&rft.date=1998-11-09&rft.volume=34&rft.issue=1-2&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+research&rft.issn=09209964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-02-02 N1 - Date created - 1999-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment of a Case of Phonological Alexia with Agraphia Using the Auditory Discrimination in Depth (ADD) Program AN - 85694412; 9911518 AB - Phonological alexia & agraphia are acquired disorders characterized by an impaired ability to convert graphemes to phonemes (alexia) or phonemes to graphemes (agraphia). These disorders result in phonological errors typified by adding, omitting, shifting, or repeating phonemes in words during reading or graphemes when spelling. In developmental dyslexia, similar phonological errors are believed to result from deficient phonological awareness, an oral language skill that manifests itself in the ability to notice, think about, or manipulate the individual sounds in words. The Auditory Discrimination in Depth (ADD) program has been reported to train phonological awareness in developmental dyslexia & dysgraphia. A multiple-probe design was used to evaluate the ADD program's effectiveness with a patient with a mild phonological alexia & mixed agraphia following a left-hemisphere infarction. Large gains in phonological awareness, reading & spelling nonwords, & reading & spelling real words were demonstrated. A follow-up reassessment, 2 months posttreatment, found the patient had maintained treatment gains in phonological awareness & reading, & attained additional improvement in real word reading. 5 Tables, 2 Figures, 66 References. Adapted from the source document JF - Journal of the International Neuropsychological Society AU - Conway, Tim W AU - Heilman, Patricia AU - Rothi, Leslie J G AU - Alexander, Ann W AU - Adair, John AU - Crosson, Bruce A AU - Heilman, Kenneth M AD - c/o Rothi-Audiology & Speech Pathology Service (126), Veterans Affairs Medical Center, 1601 SW Archer Rd, Gainesville, FL 32608 gonzalez-rothi.leslie_j@forum.va.gov Y1 - 1998/11// PY - 1998 DA - November 1998 SP - 608 EP - 620 VL - 4 IS - 6 SN - 1355-6177, 1355-6177 KW - Phonological Awareness (64970) KW - Grapheme Phoneme Correspondence (29250) KW - Phonological Processing (65110) KW - Writing Disorders (98650) KW - Dyslexia (20250) KW - article KW - 6511: learning disabilities; reading disabilities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85694412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society&rft.atitle=Treatment+of+a+Case+of+Phonological+Alexia+with+Agraphia+Using+the+Auditory+Discrimination+in+Depth+%28ADD%29+Program&rft.au=Conway%2C+Tim+W%3BHeilman%2C+Patricia%3BRothi%2C+Leslie+J+G%3BAlexander%2C+Ann+W%3BAdair%2C+John%3BCrosson%2C+Bruce+A%3BHeilman%2C+Kenneth+M&rft.aulast=Conway&rft.aufirst=Tim&rft.date=1998-11-01&rft.volume=4&rft.issue=6&rft.spage=608&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society&rft.issn=13556177&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JINSF9 N1 - SubjectsTermNotLitGenreText - Dyslexia (20250); Writing Disorders (98650); Phonological Processing (65110); Grapheme Phoneme Correspondence (29250); Phonological Awareness (64970) ER - TY - JOUR T1 - Gait in patients with cerebellar ataxia. AN - 85418052; pmid-9827622 AB - The gait pattern in 10 patients with cerebellar degenerations was studied and the results were compared with 10 matched normal subjects, seeking the principal patterns in this disorder. Gait at natural speed was studied in a biomechanics laboratory using a video-based kinematic data acquisition system for measuring body movements. Patients showed a reduced step and stride length with a trend to reduced cadence. Heel off time, toe off time, and time of peak flexion of the knee in swing were all delayed. Range of motion of ankle, knee, and hip were all reduced, but only ankle range of motion reached significance. Multijoint coordination was impaired, as indicated by a relatively greater delay of plantar flexion of the ankle compared with flexion of the knee and a relatively late knee flexion compared with hip flexion at the onset of swing. The patients also showed increased variability of almost all measures. Although some of the deviations from normal were simply the result of slowness of walking, the gait pattern of patients with cerebellar degeneration shows incoordination similar to that previously described for their multijoint limb motion. JF - Movement disorders : official journal of the Movement Disorder Society AU - Palliyath, S AU - Hallett, M AU - Thomas, S L AU - Lebiedowska, M K AD - Veterans' Administration Medical Center, New Orleans, Louisiana, USA. Y1 - 1998/11// PY - 1998 DA - November 1998 SP - 958 EP - 964 VL - 13 IS - 6 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Videotape Recording KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Biomechanics KW - Female KW - Male KW - Cerebellar Ataxia -- physiopathology KW - Gait UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85418052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Gait+in+patients+with+cerebellar+ataxia.&rft.au=Palliyath%2C+S%3BHallett%2C+M%3BThomas%2C+S+L%3BLebiedowska%2C+M+K&rft.aulast=Palliyath&rft.aufirst=S&rft.date=1998-11-01&rft.volume=13&rft.issue=6&rft.spage=958&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Human esophageal epithelial cells possess an Na+/H+ exchanger for H+ extrusion. AN - 85415462; pmid-9820376 AB - OBJECTIVE: The human esophagus is regularly exposed to refluxed gastric acid. Therefore, its epithelial cells require for survival a means of extruding excess H+ from the cytoplasm. Because Na+/H+ exchange activity has been observed in many mammalian cell types, including that of rabbit esophagus, we sought its presence in human esophageal epithelium. METHODS: Human esophageal epithelial cells derived from endoscopic biopsy specimens or surgical esophagectomy specimens were grown in primary culture and loaded with the fluorescent dye, 2'7'-bis(carboxyethyl)-5(6)-carboxyfluorescein, to monitor intracellular pH (pHi). RESULTS: Resting pHi in bicarbonate-free N'-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid was 7.5 +/- 0.03 (n = 50). Acidification using the NH4Cl prepulse technique lowered pHi by 0.6 +/- 0.02 pH units, with recovery ensuing at an initial rate of 0.09 +/- 0.04 pH units/min. Notably, the rate of recovery was faster the more acidic the pHi, and recovery was abolished by amiloride or replacement with an Na+-free buffer. Acidification by lowering pHo with HCl resulted in a similarly rapid rate of return as with the NH4Cl technique, and resting cells acidified by 0.17 +/- 0.02 pH units/5 min upon exposure to amiloride. CONCLUSIONS: Human esophageal cells possess an H+-extruding mechanism consistent with an Na+/H+ exchanger. This mechanism is active in resting cells, adapts to the degree of pHi lowering, and extrudes H+ efficiently whether loaded by intracellular or extracellular means, making it well suited for epithelial defense against acid injury. JF - The American journal of gastroenterology AU - Tobey, N A AU - Koves, G AU - Orlando, R C AD - Department of Medicine, Tulane University School of Medicine, and the Veterans Administration Medical Center, New Orleans, Louisiana, USA. Y1 - 1998/11// PY - 1998 DA - November 1998 SP - 2075 EP - 2081 VL - 93 IS - 11 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Hydrogen-Ion Concentration KW - Aged KW - Fluorescent Dyes KW - Epithelial Cells -- metabolism KW - Aged, 80 and over KW - Cells, Cultured KW - Fluoresceins -- diagnostic use KW - Adult KW - Hydrogen -- metabolism KW - Middle Aged KW - Male KW - Female KW - Esophagus -- metabolism KW - Sodium-Hydrogen Antiporter -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85415462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Human+esophageal+epithelial+cells+possess+an+Na%2B%2FH%2B+exchanger+for+H%2B+extrusion.&rft.au=Tobey%2C+N+A%3BKoves%2C+G%3BOrlando%2C+R+C&rft.aulast=Tobey&rft.aufirst=N&rft.date=1998-11-01&rft.volume=93&rft.issue=11&rft.spage=2075&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - During treatment changes in substance abuse patients with posttraumatic stress disorder. The influence of specific interventions and program environments. AN - 70114701; 9845869 AB - Male substance abuse patients with posttraumatic stress disorder (PTSD) (SA-PTSD; N = 140) were compared to patients with only substance use disorders (SA-only; N = 1,262), and those with other Axis I diagnoses (SA-PSY; N = 228) on changes during substance abuse treatment. Diagnoses were determined by chart review, and patients completed questionnaires assessing coping, cognitions, and psychological distress. Although SA-PTSD patients improved on outcomes during treatment, they showed less benefit relative to SA-only patients. At discharge, SA-PTSD patients reported less use of effective coping styles, and endorsed more positive beliefs about substance use than SA-only patients. They had more psychological distress than SA-only and SA-PSY patients. More counseling sessions devoted to substance abuse and family problems, and increased involvement in 12-step activities partially counteracted the negative effects of having a PTSD diagnosis on several outcomes. SA-PTSD patients reported fewer psychological symptoms at discharge in programs that were high in support and order/organization. JF - Journal of substance abuse treatment AU - Ouimette, P C AU - Ahrens, C AU - Moos, R H AU - Finney, J W AD - Program Evaluation, Veterans Affairs Palo Alto Health Care System, CA, USA. Ouimette@boris.icon.palo-alto.med.va.gov PY - 1998 SP - 555 EP - 564 VL - 15 IS - 6 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Veterans KW - Adaptation, Psychological KW - Humans KW - Chi-Square Distribution KW - Adult KW - Treatment Outcome KW - Surveys and Questionnaires KW - Counseling KW - Male KW - Cognition KW - Stress Disorders, Post-Traumatic -- therapy KW - Stress Disorders, Post-Traumatic -- psychology KW - Stress Disorders, Post-Traumatic -- complications KW - Patient Participation KW - Substance-Related Disorders -- complications KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70114701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=During+treatment+changes+in+substance+abuse+patients+with+posttraumatic+stress+disorder.+The+influence+of+specific+interventions+and+program+environments.&rft.au=Ouimette%2C+P+C%3BAhrens%2C+C%3BMoos%2C+R+H%3BFinney%2C+J+W&rft.aulast=Ouimette&rft.aufirst=P&rft.date=1998-11-01&rft.volume=15&rft.issue=6&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-03-16 N1 - Date created - 1999-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Factors associated with lapses to heroin use during methadone maintenance. AN - 70095920; 9839144 AB - This prospective, observational study investigated factors predicting a lapse to heroin use in 74 heroin-abstinent methadone maintenance patients. After baseline data collection, participants were assessed twice per week for 7 weeks and again at 6 months after baseline. Proportional hazards regression and logistic regression were used to investigate the effects of study predictors on heroin use. A goal of absolute heroin abstinence consistently predicted a lower risk of a lapse, whereas marijuana use was associated with a greater risk. Stress variables were not predictive. The abstinence goal and stress results were consistent with the authors' previous studies of other drug treatment samples. This line of research suggests that factors influencing lapses are similar across drug treatment populations and the role of stress in precipitating relapse remains unresolved. JF - Drug and alcohol dependence AU - Wasserman, D A AU - Weinstein, M G AU - Havassy, B E AU - Hall, S M AD - Department of Psychiatry, University of California, San Francisco 94143, USA. WASSERMAN.DAVID_A@SANFRANCISCO.VA.GOV Y1 - 1998/11/01/ PY - 1998 DA - 1998 Nov 01 SP - 183 EP - 192 VL - 52 IS - 3 SN - 0376-8716, 0376-8716 KW - Psychotropic Drugs KW - 0 KW - Street Drugs KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Street Drugs -- pharmacokinetics KW - Regression Analysis KW - Prospective Studies KW - Humans KW - Adult KW - Psychotropic Drugs -- pharmacokinetics KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Stress, Psychological -- complications KW - Methadone -- therapeutic use KW - Substance Abuse Detection KW - Heroin Dependence -- rehabilitation KW - Heroin Dependence -- psychology KW - Treatment Refusal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70095920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Factors+associated+with+lapses+to+heroin+use+during+methadone+maintenance.&rft.au=Wasserman%2C+D+A%3BWeinstein%2C+M+G%3BHavassy%2C+B+E%3BHall%2C+S+M&rft.aulast=Wasserman&rft.aufirst=D&rft.date=1998-11-01&rft.volume=52&rft.issue=3&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-02-26 N1 - Date created - 1999-02-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence of hypertension in chronic cocaine users. AN - 70079313; 9832169 AB - The association of cocaine and acute hypertension is well known; however, cocaine use has not generally been linked to chronic hypertension. We hypothesized that chronic use of cocaine over time would increase the prevalence of hypertension and that cocaine induced vasoconstriction would result in urine protein leakage, manifested by microalbuminuria. Therefore, we studied a population of predominantly black male patients admitted for addiction treatment whose drug of dependence was cocaine. A urine toxicology screen was considered positive if cocaine was detected within 24 h prior to or during admission to the hospital. A total of 301 patients with normal renal function were observed over their 2 week hospitalization. The majority (62%) of the patients were normotensive regardless of the status of their initial urine toxicology screen. Twenty percent of the population had acutely elevated blood pressure that normalized within 1 day, whereas 18% had blood pressure chronically >140/90 mm Hg (chronic hypertension). Levels of systolic and diastolic blood pressures were examined at age deciles and compared to the NHANES III (Third National Health and Nutrition Examination Survey) data for a predominantly black population. There was no significant difference in blood pressure with age in the cocaine users compared to the NHANES groups. Random urine samples were screened for the presence of microalbuminuria and no significant elevation was detected in any of the samples tested. We conclude that chronic cocaine use is associated with acute but not chronic hypertension in middle-aged black males. Cocaine use does not cause microalbuminuria. JF - American journal of hypertension AU - Brecklin, C S AU - Gopaniuk-Folga, A AU - Kravetz, T AU - Sabah, S AU - Singh, A AU - Arruda, J A AU - Dunea, G AD - Veterans Administration Chicago Healthcare System, Westside Division, University of Illinois at Chicago, 60612-7315, USA. Y1 - 1998/11// PY - 1998 DA - November 1998 SP - 1279 EP - 1283 VL - 11 IS - 11 Pt 1 SN - 0895-7061, 0895-7061 KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Blood Pressure -- drug effects KW - Albuminuria -- chemically induced KW - Male KW - Female KW - Prevalence KW - Kidney Diseases -- chemically induced KW - Hypertension -- chemically induced KW - Hypertension -- epidemiology KW - Cocaine-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70079313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hypertension&rft.atitle=Prevalence+of+hypertension+in+chronic+cocaine+users.&rft.au=Brecklin%2C+C+S%3BGopaniuk-Folga%2C+A%3BKravetz%2C+T%3BSabah%2C+S%3BSingh%2C+A%3BArruda%2C+J+A%3BDunea%2C+G&rft.aulast=Brecklin&rft.aufirst=C&rft.date=1998-11-01&rft.volume=11&rft.issue=11+Pt+1&rft.spage=1279&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hypertension&rft.issn=08957061&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-01-28 N1 - Date created - 1999-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatotoxicity related to intracavernous pharmacotherapy with papaverine. AN - 70030655; 9801111 AB - To determine the incidence of hepatotoxicity related to self-administration of intracavernous papaverine or papaverine/phentolamine (bimix). From October 1994 through June 1996, we retrospectively reviewed the medical records of 71 consecutive patients diagnosed with organic erectile dysfunction (ED) and receiving intracavernous injection therapy. Inclusion criteria were documentation of normal baseline liver function tests (LFTs), a minimum of 6 months of follow-up that included LFTs, at least one self-injection every 2 weeks, and no other prior or concurrent treatment for ED. Thirty evaluable patients satisfied the inclusion criteria and formed group 1. Mean age was 63 years (range 40 to 77), mean follow-up was 18 months (range 6 to 32), and mean number of injections per month was 5.7 (range 3 to 12). An age-matched population of 20 patients (mean age 69 years, range 46 to 90) without ED but with similar comorbid risk factors formed the control group (group 2). All patients in group 2 had routine long-term follow-up of LFTs (mean 52 months, range 10 to 1 14). Two patients (6.67%) from group 1 had elevated LFTs during treatment: one experienced a mild elevation in alanine aminotransferase and the other developed transient elevations of total bilirubin and aspartate aminotransferase 6 months after beginning therapy. Both patients reported a history of alcohol abuse. Both patients remained asymptomatic. Neither patient required discontinuation of therapy. One patient (5%) from group 2 developed an elevation of total bilirubin at a follow-up of 12 months. Routine monitoring of LFTs is probably unnecessary during intracavernous pharmacotherapy. Patients with a history of alcohol abuse or liver disease, however, should be followed up more closely when papaverine is selected for intracavernous injection. In these patients, LFTs should be obtained before initiating treatment and at 6-month intervals. JF - Urology AU - Brown, S L AU - Haas, C A AU - Koehler, M AU - Bodner, D R AU - Seftel, A D AD - Department of Urology, Cleveland Veterans Administration Medical Center, University Hospital of Cleveland, Case Western Reserve University, Ohio 44106, USA. Y1 - 1998/11// PY - 1998 DA - November 1998 SP - 844 EP - 847 VL - 52 IS - 5 SN - 0090-4295, 0090-4295 KW - Vasodilator Agents KW - 0 KW - Papaverine KW - DAA13NKG2Q KW - Phentolamine KW - Z468598HBV KW - Index Medicus KW - Humans KW - Erectile Dysfunction -- drug therapy KW - Adult KW - Retrospective Studies KW - Incidence KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Penis KW - Male KW - Chemical and Drug Induced Liver Injury -- etiology KW - Papaverine -- adverse effects KW - Chemical and Drug Induced Liver Injury -- epidemiology KW - Phentolamine -- adverse effects KW - Vasodilator Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70030655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urology&rft.atitle=Hepatotoxicity+related+to+intracavernous+pharmacotherapy+with+papaverine.&rft.au=Brown%2C+S+L%3BHaas%2C+C+A%3BKoehler%2C+M%3BBodner%2C+D+R%3BSeftel%2C+A+D&rft.aulast=Brown&rft.aufirst=S&rft.date=1998-11-01&rft.volume=52&rft.issue=5&rft.spage=844&rft.isbn=&rft.btitle=&rft.title=Urology&rft.issn=00904295&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-12-01 N1 - Date created - 1998-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transrectal ultrasound appearance of radiation-induced prostatic sarcoma. AN - 69998855; 9792135 AB - Delayed development of prostatic sarcoma is a rare complication of prostatic pelvic irradiation. The transrectal ultrasound appearance of this lesion has not been previously described. Three cases of radiation-induced prostatic sarcoma are presented, with emphasis on the transrectal ultrasound findings. An irregular, hypoechoic prostatic mass with an anechoic area consistent with the echogenicity of muscle and/or necrosis was found in all 3 patients. This appearance is distinctly dissimilar from prostatic adenocarcinoma. The sonographic finding of an irregular, hypoechoic prostatic mass with an anechoic area should raise suspicion for prostatic sarcoma in patients with a history of pelvic irradiation who develop an abnormal prostate on rectal examination and/or worsening voiding symptoms despite a normal serum prostate-specific antigen level. JF - The Prostate AU - Terris, M K AD - Section of Urology, Palo Alto Veterans Affairs Health Care System, California 94304, USA. mkt@icon.palo-alto.med.va.gov Y1 - 1998/11/01/ PY - 1998 DA - 1998 Nov 01 SP - 182 EP - 186 VL - 37 IS - 3 SN - 0270-4137, 0270-4137 KW - Index Medicus KW - Fatal Outcome KW - Rectum KW - Aged, 80 and over KW - Pelvis -- radiation effects KW - Humans KW - Ultrasonography -- methods KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Neoplasms, Radiation-Induced -- diagnostic imaging KW - Sarcoma -- diagnostic imaging KW - Prostatic Neoplasms -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69998855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Prostate&rft.atitle=Transrectal+ultrasound+appearance+of+radiation-induced+prostatic+sarcoma.&rft.au=Terris%2C+M+K&rft.aulast=Terris&rft.aufirst=M&rft.date=1998-11-01&rft.volume=37&rft.issue=3&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=The+Prostate&rft.issn=02704137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-11-12 N1 - Date created - 1998-11-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A second phase III multicenter placebo controlled study of 2 dosages of modified release tamsulosin in patients with symptoms of benign prostatic hyperplasia. United States 93-01 Study Group. AN - 69983438; 9783935 AB - In a double-blind, phase III clinical trial we evaluate the safety and efficacy of 0.4 and 0.8 mg. tamsulosin daily for the treatment of patients with symptoms of moderate to severe benign prostatic hyperplasia. Patients meeting the basic requirements of the study underwent a 4-week single-blind placebo evaluation period. A total of 735 patients were randomized to double-blind therapy with tamsulosin or placebo. Treatment duration was 13 weeks. Efficacy and safety were evaluated at 5 visits during the double-blind treatment period. When efficacy data between baseline and end point were compared there was a significant reduction in total American Urological Association symptom score (25%) in each tamsulosin group compared with placebo (p = 0.01) and the percentage of patients with a 30% or more reduction in peak urinary flow rate was significantly greater in the tamsulosin versus placebo group (p <0.05). Improvements in American Urological Association symptom scores and maximum flow rate occurred at 1 week of treatment. None of the patients experienced a first dose effect. There were no significant changes in blood pressure on standing at any visit during the study except for a decrease in systolic blood pressure of 20 mm. Hg or more between the 0.8 mg. dose and placebo groups at visit 4 (p = 0.036). Positive orthostatic tests were significantly more frequent in the 0.8 mg. group compared with placebo at visit 4 (p = 0.012). The treatment groups did not differ significantly in incidence of electrocardiogram abnormalities at each post-baseline visit and at end point. Tamsulosin was safe and effective, and clinically and statistically superior to placebo in relieving symptoms of benign prostatic hyperplasia in men with moderate to severe symptoms at baseline. There was no evidence of a first dose effect and no clinically significant orthostatic hypertension. In addition, response to treatment was rapid. JF - The Journal of urology AU - Narayan, P AU - Tewari, A AD - Division of Urology, University of Florida and Veterans Administration Medical Center, Gainesville 32610-0247, USA. Y1 - 1998/11// PY - 1998 DA - November 1998 SP - 1701 EP - 1706 VL - 160 IS - 5 SN - 0022-5347, 0022-5347 KW - Adrenergic alpha-Antagonists KW - 0 KW - Sulfonamides KW - tamsulosin KW - G3P28OML5I KW - Abridged Index Medicus KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Prostatic Hyperplasia -- drug therapy KW - Sulfonamides -- adverse effects KW - Sulfonamides -- administration & dosage KW - Adrenergic alpha-Antagonists -- administration & dosage KW - Adrenergic alpha-Antagonists -- adverse effects KW - Prostatic Hyperplasia -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69983438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=A+second+phase+III+multicenter+placebo+controlled+study+of+2+dosages+of+modified+release+tamsulosin+in+patients+with+symptoms+of+benign+prostatic+hyperplasia.+United+States+93-01+Study+Group.&rft.au=Narayan%2C+P%3BTewari%2C+A&rft.aulast=Narayan&rft.aufirst=P&rft.date=1998-11-01&rft.volume=160&rft.issue=5&rft.spage=1701&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-11-17 N1 - Date created - 1998-11-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Urol. 1998 Nov;160(5):1707-8 [9783936] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Helicobacter pylori containing only cytoplasmic urease is susceptible to acid AN - 17125023; 4433357 AB - Helicobacter pylori, an important etiologic agent in a variety of gastroduodenal diseases, produces large amounts of urease as an essential colonization factor. We have demonstrated previously that urease is located within the cytoplasm and on the surface of H. pylori both in vivo and in stationary-phase culture. The purpose of the present study was to assess the relative contributions of cytoplasmic and surface-localized urease to the ability of H. pylori to survive exposure to acid in the presence of urea. Toward this end, we compared the acid resistance in vitro of H. pylori cells which possessed only cytoplasmic urease to that of bacteria which possessed both cytoplasmic and surface-localized or extracellular urease. Bacteria with only cytoplasmic urease activity were generated by using freshly subcultured bacteria or by treating repeatedly subcultured H. pylori with flurofamide (1 mu M), a potent, but poorly diffusible urease inhibitor. H. pylori with cytoplasmic and surface-located urease activity survived in an acid environment when 5 mM urea was present. In contrast, H. pylori with only cytoplasmic urease shows significantly reduced survival when exposed to acid in the presence of 5 mM urea. Similarly, Escherichia coli SE5000 expressing H. pylori urease and the Ni super(2+) transport protein NixA, which expresses cytoplasmic urease activity at levels similar to those in wild-type H. pylori, survived minimally when exposed to acid in the presence of 5 to 50 mM urea. We conclude that cytoplasmic urease activity alone is not sufficient (although cytoplasmic urease activity is likely to be necessary) to allow survival of H. pylori in acid; the activity of surface-localized urease is essential for resistance of H. pylori to acid under the assay conditions used. Therefore, the mechanism whereby urease becomes associated with the surface of H. pylori, which involves release of the enzyme from bacteria due to autolysis followed by adsorption of the enzyme to the surface of intact bacteria ('altruistic autolysis'), is essential for survival of H. pylori in an acid environment. The ability of H. pylori to survive exposure to low pH is likely to depend on a combination of both cytoplasmic and surface-associated urease activities. JF - Infection and Immunity AU - Krishnamurthy, P AU - Parlow, M AU - Zitzer, J B AU - Vakil, N B AU - Mobley, HLT AU - Levy, M AU - Phadnis, SH AU - Dunn, B E AD - Clement J. Zablocki VA Medical Center, Pathology and Laboratory Medicine Service (113), 5000 West National Ave., Milwaukee, WI 53295-1000, USA, Bruce.Dunn@med.va.gov Y1 - 1998/11// PY - 1998 DA - Nov 1998 SP - 5060 EP - 5066 VL - 66 IS - 11 SN - 0019-9567, 0019-9567 KW - Furofamide KW - NixA protein KW - Urea KW - surfaces KW - Microbiology Abstracts B: Bacteriology KW - Helicobacter pylori KW - Cytoplasm KW - Acids KW - Escherichia coli KW - Urease KW - J 02728:Enzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17125023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Helicobacter+pylori+containing+only+cytoplasmic+urease+is+susceptible+to+acid&rft.au=Krishnamurthy%2C+P%3BParlow%2C+M%3BZitzer%2C+J+B%3BVakil%2C+N+B%3BMobley%2C+HLT%3BLevy%2C+M%3BPhadnis%2C+SH%3BDunn%2C+B+E&rft.aulast=Krishnamurthy&rft.aufirst=P&rft.date=1998-11-01&rft.volume=66&rft.issue=11&rft.spage=5060&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Helicobacter pylori; Urease; Acids; Cytoplasm ER - TY - JOUR T1 - Processing and recognition of facial affect in schizophrenia. AN - 85414277; pmid-9842589 AB - A deficit in the recognition of facial affect has been well documented in people with schizophrenia. Our 1995 research with normal subjects showed that hemispheric bias for processing facial affect is related to accuracy of recognition of facial affect. We tested whether this relationship holds in a sample of 25 people with schizophrenia who completed tasks of identification of facial affect and chimeric facial affect. Subjects with a left visual-field bias were significantly more accurate in identifying one facial emotion (sad) than were other subjects. Individual differences in hemispheric advantage for processing affect appears to be an important variable related to functional brain capacity within different populations. JF - Perceptual and motor skills AU - Federman, E J AU - Drebing, C E AU - Zaref, J I AU - Oepen, G AD - Psychology Service (116B), ENRM VA Medical Center, Bedford, MA 01730, USA. federman.ed@bedford.va.gov Y1 - 1998/10// PY - 1998 DA - October 1998 SP - 484 EP - 486 VL - 87 IS - 2 SN - 0031-5125, 0031-5125 KW - Index Medicus KW - National Library of Medicine KW - Social Perception KW - Humans KW - Visual Fields -- physiology KW - Middle Aged KW - Functional Laterality -- physiology KW - Male KW - Facial Expression KW - Schizophrenia -- diagnosis KW - Schizophrenic Psychology KW - Affect KW - Visual Perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85414277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+motor+skills&rft.atitle=Processing+and+recognition+of+facial+affect+in+schizophrenia.&rft.au=Federman%2C+E+J%3BDrebing%2C+C+E%3BZaref%2C+J+I%3BOepen%2C+G&rft.aulast=Federman&rft.aufirst=E&rft.date=1998-10-01&rft.volume=87&rft.issue=2&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+motor+skills&rft.issn=00315125&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Temporal processing in the aging auditory system. AN - 85304389; pmid-10491702 AB - Measures of monaural temporal processing and binaural sensitivity were obtained from 12 young (mean age = 26.1 years) and 12 elderly (mean age = 70.9 years) adults with clinically normal hearing (pure-tone thresholds < or = 20 dB HL from 250 to 6000 Hz). Monaural temporal processing was measured by gap detection thresholds. Binaural sensitivity was measured by interaural time difference (ITD) thresholds. Gap and ITD thresholds were obtained at three sound levels (4, 8, or 16 dB above individual threshold). Subjects were also tested on two measures of speech perception, a masking level difference (MLD) task, and a syllable identification/discrimination task that included phonemes varying in voice onset time (VOT). Elderly listeners displayed poorer monaural temporal analysis (higher gap detection thresholds) and poorer binaural processing (higher ITD thresholds) at all sound levels. There were significant interactions between age and sound level, indicating that the age difference was larger at lower stimulus levels. Gap detection performance was found to correlate significantly with performance on the ITD task for young, but not elderly adult listeners. Elderly listeners also performed more poorly than younger listeners on both speech measures; however, there was no significant correlation between psychoacoustic and speech measures of temporal processing. Findings suggest that age-related factors other than peripheral hearing loss contribute to temporal processing deficits of elderly listeners. JF - The Journal of the Acoustical Society of America AU - Strouse, A AU - Ashmead, D H AU - Ohde, R N AU - Grantham, D W AD - Division of Hearing and Speech Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA. anne.strouse@med.va.gov Y1 - 1998/10// PY - 1998 DA - October 1998 SP - 2385 EP - 2399 VL - 104 IS - 4 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Auditory Threshold -- physiology KW - Reference Values KW - Audiometry, Pure-Tone KW - Humans KW - Cochlear Nerve -- physiology KW - Aged KW - Dichotic Listening Tests KW - Reaction Time -- physiology KW - Speech Perception -- physiology KW - Adult KW - Neurons -- physiology KW - Psychoacoustics KW - Middle Aged KW - Male KW - Female KW - Aging -- physiology KW - Time Perception -- physiology KW - Auditory Perception -- physiology KW - Functional Laterality -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85304389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Temporal+processing+in+the+aging+auditory+system.&rft.au=Strouse%2C+A%3BAshmead%2C+D+H%3BOhde%2C+R+N%3BGrantham%2C+D+W&rft.aulast=Strouse&rft.aufirst=A&rft.date=1998-10-01&rft.volume=104&rft.issue=4&rft.spage=2385&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-01-15 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Role of Ca2+/calmodulin-dependent phosphatase 2B in thrombin-induced endothelial cell contractile responses. AN - 73976479; 9755112 AB - Thrombin-induced Ca2+ mobilization, activation of Ca2+/calmodulin-dependent myosin light chain (MLC) kinase (MLCK), and increased phosphorylation of MLCs precede and are critical to endothelial cell (EC) barrier dysfunction. Net MLC dephosphorylation after thrombin is nearly complete by 60 min and involves type 1 phosphatase (PPase 1) activity. We now report that thrombin does not alter total PPase 1 activity in EC homogenates but rather decreases myosin-associated PPase 1 activity. The PPase 1 inhibitor calyculin fails to prevent thrombin-induced MLC dephosphorylation. However, thrombin significantly increased the activity of Ca2+-dependent PPase 2B in EC homogenates (approximately 1.5- to 2-fold), with PPase 2B activation correlating with phosphorylation of the PPase 2B catalytic subunit. Western immunoblotting revealed PPase 2B to be present in cytoskeletal EC fractions, with specific PPase 2B inhibitors such as cyclosporin (200 nM) and deltamethrin (100 nM to 1 microM) attenuating thrombin-induced cytoskeletal protein dephosphorylation, including EC MLC dephosphorylation. These results suggest a model whereby thrombin-inducible contraction is determined by the phosphorylation status of EC MLC regulated by the balance between EC MLCK, PPase 1 (constitutive), and PPase 2B (inducible) activities. JF - The American journal of physiology AU - Verin, A D AU - Cooke, C AU - Herenyiova, M AU - Patterson, C E AU - Garcia, J G AD - Departments of Medicine, Physiology, and Biophysics, Indiana University School of Medicine, Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA. Y1 - 1998/10// PY - 1998 DA - October 1998 SP - L788 EP - L799 VL - 275 IS - 4 Pt 1 SN - 0002-9513, 0002-9513 KW - Enzyme Inhibitors KW - 0 KW - Myosin Light Chains KW - Nitriles KW - Oxazoles KW - Pyrethrins KW - decamethrin KW - 2JTS8R821G KW - Ionomycin KW - 56092-81-0 KW - calyculin A KW - 7D07U14TK3 KW - Myosin-Light-Chain Kinase KW - EC 2.7.11.18 KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - Thrombin KW - EC 3.4.21.5 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Pyrethrins -- pharmacology KW - Ionomycin -- pharmacology KW - Calcium -- metabolism KW - Cattle KW - Pulmonary Artery KW - Oxazoles -- pharmacology KW - Phosphorylation KW - Cells, Cultured KW - Kinetics KW - Enzyme Inhibitors -- pharmacology KW - Myosin Light Chains -- metabolism KW - Phosphoprotein Phosphatases -- antagonists & inhibitors KW - Myosin-Light-Chain Kinase -- metabolism KW - Endothelium, Vascular -- drug effects KW - Endothelium, Vascular -- cytology KW - Thrombin -- pharmacology KW - Phosphoprotein Phosphatases -- metabolism KW - Endothelium, Vascular -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73976479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Role+of+Ca2%2B%2Fcalmodulin-dependent+phosphatase+2B+in+thrombin-induced+endothelial+cell+contractile+responses.&rft.au=Verin%2C+A+D%3BCooke%2C+C%3BHerenyiova%2C+M%3BPatterson%2C+C+E%3BGarcia%2C+J+G&rft.aulast=Verin&rft.aufirst=A&rft.date=1998-10-01&rft.volume=275&rft.issue=4+Pt+1&rft.spage=L788&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-11-23 N1 - Date created - 1998-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic hyponatremia exacerbates ammonia-induced brain edema in rats after portacaval anastomosis. AN - 70069078; 9824268 AB - Abnormalities in brain organic osmolytes are associated with hepatic encephalopathy and with chronic hyponatremia. In spite of the high frequency of hyponatremia in acute and chronic hepatic failure, its role in the development of neurological complications in liver disease is poorly understood. We aimed to study the effect of prior hyponatremia on the development of ammonia-induced brain edema in rats after portacaval anastomosis. In this model, brain swelling is mediated in part through an increase in brain glutamine, an organic osmolyte. Hyponatremia was induced in rats with 1-desamino-8-D-arginine vasopressin (DDAVP) administered through an osmotic minipump for 1 week. This was followed by performance of a portacaval anastomosis and ammonia infusion. At the end of the infusion, brain water (density gradient) and key brain organic osmolytes (HPLC) were measured. Rats with hyponatremia showed a decrease in all three brain organic osmolytes measured: glutamine, myo-inositol and taurine. Hyperammonemia resulted in the expected rise in glutamine, with a reduction of myo-inositol and taurine. In the combined group (hyponatremia plus hyperammonemia), the rise in brain glutamine induced by ammonia infusion was attenuated (10.6+/-0.9 mM/kg vs. 15.5+/-0.8 mM/kg hyperammonemia alone; p<0.05). In spite of this limited rise in brain glutamine, ammonia infusion to hyponatremic rats exacerbated brain swelling (82.3+/-0.3% vs. 80.6+/-0.1%; p<0.05). Hyponatremia worsens brain swelling in a model of ammonia-induced brain edema. The decrease in the concentration of brain organic osmolytes induced by hyponatremia does not protect the brain from the development of ammonia-induced brain edema. JF - Journal of hepatology AU - Córdoba, J AU - Gottstein, J AU - Blei, A T AD - Department of Medicine, Veterans Administration Lakeside Medical Center and Northwestern University, Chicago, IL 60611, USA. Y1 - 1998/10// PY - 1998 DA - October 1998 SP - 589 EP - 594 VL - 29 IS - 4 SN - 0168-8278, 0168-8278 KW - Ammonia KW - 7664-41-7 KW - Index Medicus KW - Rats KW - Portacaval Shunt, Surgical KW - Animals KW - Rats, Sprague-Dawley KW - Chronic Disease KW - Brain -- metabolism KW - Hepatic Encephalopathy -- metabolism KW - Male KW - Hyponatremia -- complications KW - Brain Edema -- etiology KW - Ammonia -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70069078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=Chronic+hyponatremia+exacerbates+ammonia-induced+brain+edema+in+rats+after+portacaval+anastomosis.&rft.au=C%C3%B3rdoba%2C+J%3BGottstein%2C+J%3BBlei%2C+A+T&rft.aulast=C%C3%B3rdoba&rft.aufirst=J&rft.date=1998-10-01&rft.volume=29&rft.issue=4&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=01688278&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-01-07 N1 - Date created - 1999-01-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impairment of semantic and figural memory by acute ethanol: age-dependent effects. AN - 70017856; 9802525 AB - Alcohol drinking is prevalent among young adults in the U.S. Moreover, heavy drinking is acknowledged by a substantial percentage of young adults in both college and military subpopulations, despite the known cognitive demands associated with these endeavors and the cognitive impairments associated with alcohol usage. We assessed the acute effects of ethanol (0.6 g/kg) on the acquisition of both semantic and figural memory in a sample of young adults from 21 to 29 years of age using a repeated-measures, placebo-controlled experimental design. Ethanol significantly impaired memory acquisition in both domains. In addition, the effect of ethanol on three of the four memory measures assessed was dependent on the age of the subjects. Subjects in a young subgroup (21 to 24 years of age) were significantly more impaired in memory measures than those in the subgroup that was 25 to 29 years of age. These results indicate a divergence of the potency of ethanol against memory acquisition across a narrow age range in early adulthood. Whereas these data are preliminary, and should be generalized cautiously, they are also consistent with a growing literature using animal models that indicates that acute ethanol is a more potent antagonist of memory and memory-related hippocampal activity in adolescent animals compared with adults. JF - Alcoholism, clinical and experimental research AU - Acheson, S K AU - Stein, R M AU - Swartzwelder, H S AD - Department of Psychiatry, Duke University Medical Center, Veterans Administration Medical Center, Durham, North Carolina, USA. Y1 - 1998/10// PY - 1998 DA - October 1998 SP - 1437 EP - 1442 VL - 22 IS - 7 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Age Factors KW - Humans KW - Adult KW - Male KW - Female KW - Pattern Recognition, Visual -- drug effects KW - Ethanol -- adverse effects KW - Alcoholic Intoxication -- psychology KW - Verbal Learning -- drug effects KW - Mental Recall -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70017856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Impairment+of+semantic+and+figural+memory+by+acute+ethanol%3A+age-dependent+effects.&rft.au=Acheson%2C+S+K%3BStein%2C+R+M%3BSwartzwelder%2C+H+S&rft.aulast=Acheson&rft.aufirst=S&rft.date=1998-10-01&rft.volume=22&rft.issue=7&rft.spage=1437&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-02-04 N1 - Date created - 1999-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Water soluble antioxidants in mammalian aqueous humor: interaction with UV B and hydrogen peroxide. AN - 70014567; 9797984 AB - HPLC/electrochemical detection was used to identify five major low MW water soluble electrochemically active molecules from the aqueous humor of three species of mammals: New Zealand White rabbits and humans (diurnal) and Sprague-Dawley rats (nocturnal). These molecules are L-cysteine (CYS), L-ascorbic acid (AA), glutathione (GSH), uric acid (UA) and L-tyrosine (TYR); all of these molecules have known antioxidant properties. Nocturnal rat aqueous humor is concentrated in two thiols: GSH (125 microM; n = 24 pooled eyes) and CYS (63 microM), in contradistinction to diurnal species which have high concentrations of AA. No deterioration of any of these antioxidants occurs in a synthetic aqueous humor mixture irradiated with a physiologically relevant spectral UV B dose of 30 mJ/cm2/h (5.5 UV equivalent sunlight hours). The same result occurred with addition of the endogenous aqueous humor UV B photosensitizer L-tryptophan. In a second set of experiments, human synthetic aqueous humor was subjected to hydrogen peroxide induced oxidant stress. The decay of antioxidants was CYS > GSH > AA > UA > TYR. The second highest concentrated antioxidant in human aqueous humor is TYR. Yet TYR failed to protect AA against H2O2-induced free radical damage in a synthetic aqueous humor model system (P = 0.10; ANOVA). The existence of multiple electrochemically active constituents and their thermodynamic interactions must be recognized when choosing animal models to evaluate human aqueous humor antioxidant defense. JF - Vision research AU - Richer, S P AU - Rose, R C AD - Department of Veteran Affairs Medical Center, Eye Clinic, North Chicago, IL 60064-3095, USA. Richer,s@n-chicago.va.gov Y1 - 1998/10// PY - 1998 DA - October 1998 SP - 2881 EP - 2888 VL - 38 IS - 19 SN - 0042-6989, 0042-6989 KW - Antioxidants KW - 0 KW - Oxidants KW - Uric Acid KW - 268B43MJ25 KW - Tyrosine KW - 42HK56048U KW - Tryptophan KW - 8DUH1N11BX KW - Hydrogen Peroxide KW - BBX060AN9V KW - Glutathione KW - GAN16C9B8O KW - Cysteine KW - K848JZ4886 KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Animals KW - Tryptophan -- pharmacology KW - Analysis of Variance KW - Oxidants -- pharmacology KW - Mammals KW - Humans KW - Cysteine -- analysis KW - Hydrogen Peroxide -- pharmacology KW - Aged KW - Disease Models, Animal KW - Rabbits KW - Ascorbic Acid -- analysis KW - Chromatography, High Pressure Liquid KW - Tyrosine -- analysis KW - Rats KW - Cataract -- metabolism KW - Rats, Sprague-Dawley KW - Uric Acid -- analysis KW - Glutathione -- analysis KW - Female KW - Antioxidants -- analysis KW - Aqueous Humor -- drug effects KW - Aqueous Humor -- chemistry KW - Ultraviolet Rays -- adverse effects KW - Aqueous Humor -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70014567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vision+research&rft.atitle=Water+soluble+antioxidants+in+mammalian+aqueous+humor%3A+interaction+with+UV+B+and+hydrogen+peroxide.&rft.au=Richer%2C+S+P%3BRose%2C+R+C&rft.aulast=Richer&rft.aufirst=S&rft.date=1998-10-01&rft.volume=38&rft.issue=19&rft.spage=2881&rft.isbn=&rft.btitle=&rft.title=Vision+research&rft.issn=00426989&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-11-10 N1 - Date created - 1998-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bupropion treatment in veterans with posttraumatic stress disorder: an open study. AN - 69998991; 9790155 AB - This study was designed to investigate the efficacy of the antidepressant drug bupropion in the treatment of posttraumatic stress disorder (PTSD). Seventeen male combat veterans with chronic PTSD were treated with bupropion in an open-label fashion for 6 weeks. Patients were evaluated with the Clinical Global Impressions Scale for Improvement (CGI-I) at follow-up and rated blindly at baseline and posttreatment with the Clinician Administered PTSD Scale (CAPS), the Hamilton Rating Scale for Depression (HAM-D), and the Hamilton Rating Scale for Anxiety. Three patients discontinued bupropion prematurely because of side effects. Of the remaining 14 patients, 10 were classified as treatment responders by the CGI-I. HAM-D scores decreased significantly from baseline to follow-up. The improvement seen in hyperarousal symptoms was significant but was less significant than the change in depressive symptoms. There was no significant change in Intrusion, Avoidance, or total CAPS scores. It was concluded that bupropion was well tolerated. Patients who had experienced sexual dysfunction with selective serotonin reuptake inhibitors reported no complaints during bupropion treatment. Bupropion decreased depressive symptoms and most patients reported global improvement, although PTSD symptoms remained mostly unchanged. Controlled trials should further clarify the role of bupropion in the treatment of PTSD. JF - Journal of clinical psychopharmacology AU - Cañive, J M AU - Clark, R D AU - Calais, L A AU - Qualls, C AU - Tuason, V B AD - VA Medical Center and the University of New Mexico Health Sciences Center, Albuquerque, 87108, USA. CANIVE_JOSE_M@Albuquerque.VA.GOV Y1 - 1998/10// PY - 1998 DA - October 1998 SP - 379 EP - 383 VL - 18 IS - 5 SN - 0271-0749, 0271-0749 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Bupropion KW - 01ZG3TPX31 KW - Index Medicus KW - Personality Inventory -- statistics & numerical data KW - Humans KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Chronic Disease KW - Psychometrics KW - Male KW - Combat Disorders -- psychology KW - Antidepressive Agents, Second-Generation -- adverse effects KW - Combat Disorders -- drug therapy KW - Antidepressive Agents, Second-Generation -- administration & dosage KW - Veterans -- psychology KW - Combat Disorders -- diagnosis KW - Bupropion -- adverse effects KW - Bupropion -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69998991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Bupropion+treatment+in+veterans+with+posttraumatic+stress+disorder%3A+an+open+study.&rft.au=Ca%C3%B1ive%2C+J+M%3BClark%2C+R+D%3BCalais%2C+L+A%3BQualls%2C+C%3BTuason%2C+V+B&rft.aulast=Ca%C3%B1ive&rft.aufirst=J&rft.date=1998-10-01&rft.volume=18&rft.issue=5&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-01-29 N1 - Date created - 1999-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Monoclonal antibodies in the treatment of human B-cell malignancies. AN - 69099154; 9869188 AB - Monoclonal antibody technology emerged in the 1970's and was greeted by a wave of optimism. Many believed this new form of therapy would be effective in the treatment of human cancers. Early clinical trials in B-cell lymphomas demonstrated both the potential and limitations of unlabeled murine monoclonal antibody therapy, and taught us valuable lessons regarding the importance of the antibody structure, and nature of the targeted antigen. Since that time modifications in antibody structure and careful selection of target antigen have improved the clinical efficacy of these agents. Clinical trials using humanized antibodies have demonstrated that human/mouse chimeric antibodies and humanized antibodies have enhanced anti-tumor activity, decreased immunogenicity, and a very favorable toxicity profile. Radiolabeled monoclonal antibodies can induce durable remissions in lymphoma with toxicity limited largely to bone marrow suppression. Clinical trials with immunotoxins have demonstrated anti-tumor activity but also have been associated with significant toxicity. Standard treatment options for B-cell lymphoma will soon include antibody-based therapies. Further basic and clinical research is needed so we can understand more thoroughly the mechanisms responsible for the observed anti-tumor effects, and explore more extensively the best approach to their clinical use. JF - Leukemia & lymphoma AU - Link, B K AU - Weiner, G J AD - Department of Internal Medicine, University of Iowa College of Medicine and the Iowa City Veterans Administration Medical Center, USA. Y1 - 1998/10// PY - 1998 DA - October 1998 SP - 237 EP - 249 VL - 31 IS - 3-4 SN - 1042-8194, 1042-8194 KW - Antibodies, Neoplasm KW - 0 KW - Immunotoxins KW - Index Medicus KW - Humans KW - Lymphoma, B-Cell -- therapy KW - Lymphoma, B-Cell -- immunology KW - Immunotherapy KW - Antibodies, Neoplasm -- therapeutic use KW - Immunotoxins -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69099154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+%26+lymphoma&rft.atitle=Monoclonal+antibodies+in+the+treatment+of+human+B-cell+malignancies.&rft.au=Link%2C+B+K%3BWeiner%2C+G+J&rft.aulast=Link&rft.aufirst=B&rft.date=1998-10-01&rft.volume=31&rft.issue=3-4&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Leukemia+%26+lymphoma&rft.issn=10428194&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-03-03 N1 - Date created - 1999-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of restriction enzyme analysis, arbitrarily primed PCR, and protein profile analysis typing for epidemiologic investigation of an ongoing Clostridium difficile outbreak AN - 17126835; 4436441 AB - During an outbreak of diarrhea in a general hospital in 1992, 166 Clostridium difficile isolates from 102 patients were typed by restriction enzyme analysis (REA), arbitrarily primed PCR (AP-PCR), and protein profile analysis (PP) techniques. A total of 18 types and 5 subtypes were identified by REA, 32 types were identified by AP-PCR, and 9 types were identified by PP. Analysis of the data indicated the presence of a predominant strain among 76, 75, and 84% of the isolates by REA, AP-PCR, and PP, respectively. Subsequently, 45 C. difficile isolates which had been collected in 1990 from 33 patients in the same hospital following a significant increase in the number of cases of diarrhea caused by C. difficile were studied by REA, AP-PCR, and PP typing techniques. Thirteen types and one subtype were identified by REA, 12 types were identified by AP-PCR, and 5 types were identified by PP. As with the isolates from 1992, a dominant strain was identified. This strain was represented by 53, 64, and 70% of the total number of isolates when the strains were typed by REA, AP-PCR, and PP, respectively. Every isolate (210 of 211) from both 1990 and 1992 that was available for typing was typeable by all three methods. Furthermore, the same dominant strain was identified in both 1990 and 1992 by each method. This study demonstrates that each of the three typing methods can be useful in epidemiologic investigations of C. difficile outbreaks and that one strain can be dominant in an institution over a number of years. JF - Journal of Clinical Microbiology AU - Rafferty, ME AU - Baltch, AL AU - Smith, R P AU - Bopp, L H AU - Rheal, C AU - Tenover, F C AU - Killgore, GE AU - Lyerly, D M AU - Wilkins, T D AU - Schoonmaker, D J AU - Hannett, GE AU - Shayegani, M AD - Infectious Disease Section, 111D, Stratton VA Medical Center, 113 Holland Ave., Albany, NY 12208, USA, Baltch.Aldona@Albany.VA.gov Y1 - 1998/10// PY - 1998 DA - Oct 1998 SP - 2957 EP - 2963 VL - 36 IS - 10 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Diarrhea KW - Epidemiology KW - Protein composition KW - Restriction endonuclease mapping KW - Polymerase chain reaction KW - Clostridium difficile KW - J 02846:Gastrointestinal tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17126835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Comparison+of+restriction+enzyme+analysis%2C+arbitrarily+primed+PCR%2C+and+protein+profile+analysis+typing+for+epidemiologic+investigation+of+an+ongoing+Clostridium+difficile+outbreak&rft.au=Rafferty%2C+ME%3BBaltch%2C+AL%3BSmith%2C+R+P%3BBopp%2C+L+H%3BRheal%2C+C%3BTenover%2C+F+C%3BKillgore%2C+GE%3BLyerly%2C+D+M%3BWilkins%2C+T+D%3BSchoonmaker%2C+D+J%3BHannett%2C+GE%3BShayegani%2C+M&rft.aulast=Rafferty&rft.aufirst=ME&rft.date=1998-10-01&rft.volume=36&rft.issue=10&rft.spage=2957&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Clostridium difficile; Protein composition; Polymerase chain reaction; Restriction endonuclease mapping; Diarrhea; Epidemiology ER - TY - JOUR T1 - Comparison of inhibitory and bactericidal activities and postantibiotic effects of LY333328 and ampicillin used singly and in combination against vancomycin-resistant Enterococcus faecium AN - 17123142; 4433330 AB - One hundred ninety-five individual vancomycin-resistant Enterococcus faecium (VRE) isolates from five upstate New York hospitals were studied for antimicrobial susceptibilities to LY333328, quinupristin-dalfopristin, teicoplanin, ampicillin, and gentamicin. LY333328 was the most active antibiotic against VRE. The effect of media and methods on the antibacterial activity of LY333328, its synergy with ampicillin, and the post-antibiotic effects (PAE) of LY333328 and ampicillin were evaluated. In microdilution tests, the MIC of LY333328 at which 90% of the isolates were inhibited (MIC sub(90)) was 2 mu g/ml in Mueller-Hinton II (MH II) broth and 1 mu g/ml in brain heart infusion (BHI) broth. In contrast, on MH II agar the MIC sub(90) was 4 mu g/ml and on BHI agar it was >16 mu g/ml. Bactericidal activity was observed for most strains at concentrations from 8 to greater than or equal to 133 times the MIC of the tube macrodilution in MH II broth. A bactericidal effect of LY333328 plus ampicillin was demonstrated in time-kill studies, but there was great strain-to-strain variability. By the MH II agar dilution method, bacteristatic synergy (defined as a fractional inhibitory concentration of <0.5) with LY333328 and ampicillin was demonstrated for 61% of the strains tested. Under similar conditions, there was synergy with LY333328 and quinupristin-dalfopristin or gentamicin for 27 and 15% of the strains tested, respectively. The PAE of LY333328 was prolonged (23.0 h at 10 times the MIC). However, 50% normal pooled human serum decreased the PAE to 12.2 h at 10 times the MIC. Test conditions and media had a considerable effect on VRE susceptibilities to LY333328. The prolonged PAE of LY333328, a potent new bactericidal glycopeptide, and its synergy with ampicillin in a large proportion of strains suggest that further evaluation of this drug in pharmacokinetic studies and experimental infections, including those with VRE, is warranted. JF - Antimicrobial Agents & Chemotherapy AU - Baltch, AL AU - Smith, R P AU - Ritz, W J AU - Bopp, L H AD - Infectious Disease Section, 111D, Stratton VA Medical Center, 113 Holland Ave., Albany, NY 12208, USA, BALTCH.ALDONA@Albany.va.gov Y1 - 1998/10// PY - 1998 DA - Oct 1998 SP - 2564 EP - 2568 VL - 42 IS - 10 SN - 0066-4804, 0066-4804 KW - LY-333328 KW - Quinupristin KW - dalfopristin KW - glycoproteins KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Teicoplanin KW - Enterococcus faecium KW - Bactericides KW - Vancomycin KW - Antibiotic resistance KW - Synergism KW - Ampicillin KW - Minimum inhibitory concentration KW - Gentamicin KW - J 02785:Beta-lactam antibiotics KW - A 01064:Microbial resistance KW - J 02787:Peptide and protein antibiotics KW - A 01074:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17123142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Comparison+of+inhibitory+and+bactericidal+activities+and+postantibiotic+effects+of+LY333328+and+ampicillin+used+singly+and+in+combination+against+vancomycin-resistant+Enterococcus+faecium&rft.au=Baltch%2C+AL%3BSmith%2C+R+P%3BRitz%2C+W+J%3BBopp%2C+L+H&rft.aulast=Baltch&rft.aufirst=AL&rft.date=1998-10-01&rft.volume=42&rft.issue=10&rft.spage=2564&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Enterococcus faecium; Bactericides; Gentamicin; Antibiotic resistance; Vancomycin; Ampicillin; Teicoplanin; Minimum inhibitory concentration; Synergism ER - TY - JOUR T1 - NT-3 attenuates functional and structural disorders in sensory nerves of galactose-fed rats. AN - 73890788; 9737543 AB - The present study investigated the effect of NT-3, a neurotrophin expressed in nerve and skeletal muscle, on myelinated fiber disorders of galactose-fed rats. Adult, female Sprague-Dawley rats were fed diets containing complete micronutrient supplements and either 0% D-galactose (control) or 40% D-galactose. Treated controls received 20 mg/kg NT-3 and treated galactose-fed rats received 1, 5, or 20 mg/kg NT-3 three times per week by subcutaneous injections. After 2 months, sciatic and saphenous sensory nerve conduction velocity (SNCV) and sciatic motor nerve conduction velocity (MNCV) were measured and the sciatic, sural, peroneal and saphenous nerves and dorsal and ventral roots processed for light microscopy. Treatment of control animals with NT-3 had no effect on any functional or structural parameter. Compared to control values, galactose feeding induced a sensory and motor nerve conduction deficit and a reduction in axonal caliber. Treatment with 5 and 20 mg/kg NT-3 ameliorated deficits in sciatic and saphenous SNCV in galactose-fed rats but had no effect on the MNCV deficit. NT-3 treatment also attenuated the decrease in mean axonal caliber in the dorsal root and sural nerve but not in the saphenous nerve, ventral root and peroneal nerve. These observations show that NT-3 can selectively attenuate the sensory conduction deficit of galactose neuropathy in a dose-dependent manner that depends only in part on restoration of axonal caliber of large-fiber sensory neurons. JF - Journal of neuropathology and experimental neurology AU - Mizisin, A P AU - Kalichman, M W AU - Bache, M AU - Dines, K C AU - DiStefano, P S AD - Department of Pathology, University of California, San Diego, the Veterans Administration Medical Center, La Jolla 92093-0612, USA. Y1 - 1998/09// PY - 1998 DA - September 1998 SP - 803 EP - 813 VL - 57 IS - 9 SN - 0022-3069, 0022-3069 KW - Nerve Growth Factors KW - 0 KW - Neurotrophin 3 KW - Recombinant Proteins KW - Galactose KW - X2RN3Q8DNE KW - Index Medicus KW - Animals KW - Motor Neurons -- physiology KW - Recombinant Proteins -- pharmacology KW - Axons -- drug effects KW - Humans KW - Sciatic Nerve -- physiology KW - Sciatic Nerve -- physiopathology KW - Sciatic Nerve -- drug effects KW - Neurons, Afferent -- physiology KW - Peroneal Nerve -- physiopathology KW - Axons -- physiology KW - Rats KW - Motor Neurons -- pathology KW - Rats, Sprague-Dawley KW - Food, Fortified KW - Injections, Subcutaneous KW - Peroneal Nerve -- drug effects KW - Neurons, Afferent -- drug effects KW - Peroneal Nerve -- physiology KW - Motor Neurons -- drug effects KW - Recombinant Proteins -- administration & dosage KW - Female KW - Neurons, Afferent -- pathology KW - Spinal Nerve Roots -- drug effects KW - Spinal Nerves -- drug effects KW - Spinal Nerves -- physiology KW - Nerve Growth Factors -- pharmacology KW - Galactose -- administration & dosage KW - Neural Conduction -- drug effects KW - Galactose -- toxicity KW - Nerve Growth Factors -- physiology KW - Spinal Nerves -- physiopathology KW - Neural Conduction -- physiology KW - Spinal Nerve Roots -- pathology KW - Spinal Nerve Roots -- physiology KW - Galactose -- antagonists & inhibitors KW - Nerve Growth Factors -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73890788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuropathology+and+experimental+neurology&rft.atitle=NT-3+attenuates+functional+and+structural+disorders+in+sensory+nerves+of+galactose-fed+rats.&rft.au=Mizisin%2C+A+P%3BKalichman%2C+M+W%3BBache%2C+M%3BDines%2C+K+C%3BDiStefano%2C+P+S&rft.aulast=Mizisin&rft.aufirst=A&rft.date=1998-09-01&rft.volume=57&rft.issue=9&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuropathology+and+experimental+neurology&rft.issn=00223069&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-09-25 N1 - Date created - 1998-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The TE promoter element of the histone H1t gene is essential for transcription in transgenic mouse primary spermatocytes. AN - 73871409; 9716572 AB - Transcriptional activation of the testis-specific histone H1t gene occurs in pachytene primary spermatocytes during spermatogenesis. Specific binding of testis nuclear proteins to a rat histone H1t promoter sequence, designated the H1t/TE element, correlates with the onset of transcription. This element, located between the H1t/AC box and the H1t/CCAAT box, contains inverted repeats of a shorter element. When the native rat H1t gene along with flanking sequences, including 2453 base pairs (bp) upstream and 3784 bp downstream from the coding region, was microinjected into mouse embryos, the offspring of the resulting transgenic mice transcribed the transgene in a tissue-specific manner and only in primary spermatocytes. In the present study the TE promoter element was deleted and replaced with a heterologous stuffer DNA fragment. When the mutant rat DNA fragment was used to create transgenic mice, offspring of the mice bearing the promoter mutation did not transcribe the rat H1t gene in any tissue. On the other hand, transcription of the rat H4t transgene, which is located approximately 1.5 kilobases downstream from the H1t gene, occurred in these animals. Therefore, these studies support the hypothesis that the TE element is essential for enhanced testis-specific transcription of the H1t gene in primary spermatocytes. JF - Biology of reproduction AU - vanWert, J M AU - Panek, H R AU - Wolfe, S A AU - Grimes, S R AD - Research Service (151), Overton Brooks Veterans Administration Medical Center, Shreveport, Louisiana 71101-4295, USA. Y1 - 1998/09// PY - 1998 DA - September 1998 SP - 704 EP - 710 VL - 59 IS - 3 SN - 0006-3363, 0006-3363 KW - Histones KW - 0 KW - RNA, Messenger KW - Index Medicus KW - Animals KW - Testis -- metabolism KW - Humans KW - Mice KW - Mice, Transgenic KW - Gene Deletion KW - Mutagenesis KW - Rats KW - Base Sequence KW - RNA, Messenger -- metabolism KW - Molecular Sequence Data KW - Repetitive Sequences, Nucleic Acid KW - TATA Box KW - Male KW - Promoter Regions, Genetic KW - Spermatocytes -- metabolism KW - Transcription, Genetic KW - Histones -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73871409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+reproduction&rft.atitle=The+TE+promoter+element+of+the+histone+H1t+gene+is+essential+for+transcription+in+transgenic+mouse+primary+spermatocytes.&rft.au=vanWert%2C+J+M%3BPanek%2C+H+R%3BWolfe%2C+S+A%3BGrimes%2C+S+R&rft.aulast=vanWert&rft.aufirst=J&rft.date=1998-09-01&rft.volume=59&rft.issue=3&rft.spage=704&rft.isbn=&rft.btitle=&rft.title=Biology+of+reproduction&rft.issn=00063363&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-10-05 N1 - Date created - 1998-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toxic effects of capsaicin on keratinocytes and fibroblasts. AN - 69994469; 9789176 AB - Pain management for partial-thickness burns and split-thickness skin graft donor sites remains a persistent problem. Topical capsaicin (trans-b-methyl-N-vanillyl-noneamide) has been successful for pain relief in postherpetic neuralgia, arthritis, and diabetic neuropathy. It is thought to work by inhibiting type C cutaneous factors and by releasing substance P, which is essential for wound healing. To evaluate the effects of topical capsaicin treatment on burn wounds and donor sites, an in vitro study was designed to consider cytotoxic effects of commercial concentrations of capsaicin on keratinocytes and fibroblasts. Human keratinocytes and human fibroblasts were grown in tissue culture and exposed to varying concentrations of capsaicin (0.025% weight/volume to 0.2% weight/volume). In addition, fibroblast-seeded collagen matrixes were exposed to capsaicin to evaluate the compound's ability to cause cytotoxic effects beneath the surface. Keratinocyte growth was reduced 21% to 31% in commercial concentrations of capsaicin 0.025% to 0.20% weight/volume. Fibroblasts were reduced 5% to 10% during the first 6 hours of exposure to capsaicin and 30% after 24 hours across the full range of concentrations tested. At concentrations of at least 0.1% weight/volume, capsaicin penetrated the collagen matrixes, resulting in fibroblast degeneration not only on the surface but also in the inner layers. On the basis of the fact that capsaicin was demonstrated to be cytotoxic to keratinocytes and fibroblasts and on the basis of its known detrimental effect on wound healing, it does not appear that topical capsaicin is indicated for the treatment of burns. JF - The Journal of burn care & rehabilitation AU - Ko, F AU - Diaz, M AU - Smith, P AU - Emerson, E AU - Kim, Y J AU - Krizek, T J AU - Robson, M C AD - Bay Pines Veterans Administration Medical Center, Institute of Tissue Regeneration, Repair and Rehabilitation, FL 33744, USA. PY - 1998 SP - 409 EP - 413 VL - 19 IS - 5 SN - 0273-8481, 0273-8481 KW - Substance P KW - 33507-63-0 KW - Collagen KW - 9007-34-5 KW - Capsaicin KW - S07O44R1ZM KW - Index Medicus KW - Rats KW - Extracellular Matrix -- drug effects KW - Collagen -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Pain -- drug therapy KW - Cells, Cultured KW - Wound Healing -- drug effects KW - Humans KW - Substance P -- drug effects KW - Burns -- physiopathology KW - Fibroblasts -- drug effects KW - Capsaicin -- toxicity KW - Keratinocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69994469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+burn+care+%26+rehabilitation&rft.atitle=Toxic+effects+of+capsaicin+on+keratinocytes+and+fibroblasts.&rft.au=Ko%2C+F%3BDiaz%2C+M%3BSmith%2C+P%3BEmerson%2C+E%3BKim%2C+Y+J%3BKrizek%2C+T+J%3BRobson%2C+M+C&rft.aulast=Ko&rft.aufirst=F&rft.date=1998-09-01&rft.volume=19&rft.issue=5&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+burn+care+%26+rehabilitation&rft.issn=02738481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-12-21 N1 - Date created - 1998-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enterococcus faecalis endocarditis presenting as meningitis AN - 19606463; 8597896 AB - AlthoughEnterococcus faecalis is a relatively common cause of infective endocarditis, it rarely causes meningitis. A case ofEnterococcus faecalis endocarditis presenting as meningitis in a 74-year-old diabetic man on chronic hemodialysis is reported. A review of the literature showed that the association of enterococcal meningitis and endocarditis has rarely reported. This clinical association may be more common than previously recognized and it is suggested that echocardiography be considered for all patients with enterococcal hematogenous meningitis in order to rule out endocarditis. JF - Infection AU - Lin, D P AU - Wada, S AU - Jimenez-Lucho, V AD - Northport Veterans Administration Medical Center, 79 Middleville Road, 11768-2290, Northport, NY, USA Y1 - 1998/09// PY - 1998 DA - Sep 1998 SP - 304 EP - 305 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 26 IS - 5 SN - 0300-8126, 0300-8126 KW - Microbiology Abstracts B: Bacteriology KW - Diabetes mellitus KW - Echocardiography KW - Enterococcus faecalis KW - Hemodialysis KW - Endocarditis KW - Meningitis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19606463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection&rft.atitle=Enterococcus+faecalis+endocarditis+presenting+as+meningitis&rft.au=Lin%2C+D+P%3BWada%2C+S%3BJimenez-Lucho%2C+V&rft.aulast=Lin&rft.aufirst=D&rft.date=1998-09-01&rft.volume=26&rft.issue=5&rft.spage=304&rft.isbn=&rft.btitle=&rft.title=Infection&rft.issn=03008126&rft_id=info:doi/10.1007%2FBF02962253 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Echocardiography; Hemodialysis; Meningitis; Endocarditis; Enterococcus faecalis DO - http://dx.doi.org/10.1007/BF02962253 ER - TY - JOUR T1 - Vaccination with BV8S2 Protein Amplifies TCR- Specific Regulation and Protection Against Experimental Autoimmune Encephalomyelitis in TCR BV8S2 Transgenic Mice AN - 16527452; 4368503 AB - TCR determinants overexpressed by autopathogenic Th1 cells can naturally induce a second set of TCR-specific regulatory T cells. We addressed the question of whether immune regulation could be induced naturally in a genetically restricted model in which a major portion of TCR-specific regulatory T cells expressed the same target TCR BV8S2 chain as the pathogenic T cells specific for myelin basic protein (MBP). We found vigorous T cell responses to BV8S2 determinants in naive mice that could be further potentiated by vaccination with heterologous BV8S2 proteins, resulting in the selective inhibition of MBP-specific Th1 cells and protection against experimental encephalomyelitis. Moreover, coculture with BV8S2- specific T cells or their supernatants reduced proliferation, IFN- gamma secretion, and encephalitogenic activity of MBP-specific T cells. These results suggest that immune regulation occurs through a nondeletional cytokine-driven suppressive mechanism. JF - Journal of Immunology AU - Offner, H AU - Adlard, K AU - Bebo, B F AU - Schuster, J AU - Burrows, G G AU - Buenafe, A C AU - Vandenbark, A A AD - Neuroimmunology Research R&D-31, Protland Veterans Affairs Medical Center, 3710 SW Veterans Hospital Road, Portland, OR 97201 USA, offner.halina@portland.va.gov Y1 - 1998/09/01/ PY - 1998 DA - 1998 Sep 01 SP - 2178 EP - 2186 VL - 161 IS - 5 SN - 0022-1767, 0022-1767 KW - BV8S2 protein KW - transgenic mice KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - F 06872:EAE (multiple sclerosis) KW - W3 33190:Therapy: Other KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16527452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Vaccination+with+BV8S2+Protein+Amplifies+TCR-+Specific+Regulation+and+Protection+Against+Experimental+Autoimmune+Encephalomyelitis+in+TCR+BV8S2+Transgenic+Mice&rft.au=Offner%2C+H%3BAdlard%2C+K%3BBebo%2C+B+F%3BSchuster%2C+J%3BBurrows%2C+G+G%3BBuenafe%2C+A+C%3BVandenbark%2C+A+A&rft.aulast=Offner&rft.aufirst=H&rft.date=1998-09-01&rft.volume=161&rft.issue=5&rft.spage=2178&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. AN - 73896944; 9721099 AB - Glutamatergic abnormalities have been associated with several psychiatric disorders, including schizophrenia and addiction. Group II metabotropic glutamate receptors were targeted to normalize glutamatergic disruptions associated with an animal model of schizophrenia, the phencyclidine model. An agonist of this group of receptors, at a dose that was without effects on spontaneous activity and corticolimbic dopamine neurotransmission, attenuated the disruptive effects of phencyclidine on working memory, stereotypy, locomotion, and cortical glutamate efflux. This behavioral reversal occurred in spite of sustained dopamine hyperactivity. Thus, targeting this group of receptors may present a nondopaminergic therapeutic strategy for treatment of psychiatric disorders. JF - Science (New York, N.Y.) AU - Moghaddam, B AU - Adams, B W AD - Department of Psychiatry, Yale University School of Medicine, Veterans Administration Medical Center 116A/2, West Haven, CT 06516, USA. Y1 - 1998/08/28/ PY - 1998 DA - 1998 Aug 28 SP - 1349 EP - 1352 VL - 281 IS - 5381 SN - 0036-8075, 0036-8075 KW - Bridged Bicyclo Compounds KW - 0 KW - Excitatory Amino Acid Agonists KW - Receptors, Metabotropic Glutamate KW - metabotropic glutamate receptor 2 KW - Glutamic Acid KW - 3KX376GY7L KW - Phencyclidine KW - J1DOI7UV76 KW - eglumetad KW - ONU5A67T2S KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Glutamic Acid -- metabolism KW - Prefrontal Cortex -- metabolism KW - Memory -- drug effects KW - Nucleus Accumbens -- drug effects KW - Synaptic Transmission -- drug effects KW - Disease Models, Animal KW - Dopamine -- metabolism KW - Stereotyped Behavior -- drug effects KW - Prefrontal Cortex -- drug effects KW - Rats KW - Rats, Sprague-Dawley KW - Nucleus Accumbens -- metabolism KW - Motor Activity -- drug effects KW - Male KW - Bridged Bicyclo Compounds -- pharmacology KW - Schizophrenia -- metabolism KW - Excitatory Amino Acid Agonists -- therapeutic use KW - Receptors, Metabotropic Glutamate -- metabolism KW - Phencyclidine -- pharmacology KW - Excitatory Amino Acid Agonists -- pharmacology KW - Excitatory Amino Acid Agonists -- administration & dosage KW - Bridged Bicyclo Compounds -- therapeutic use KW - Schizophrenia -- drug therapy KW - Schizophrenia -- chemically induced KW - Receptors, Metabotropic Glutamate -- agonists KW - Bridged Bicyclo Compounds -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73896944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Reversal+of+phencyclidine+effects+by+a+group+II+metabotropic+glutamate+receptor+agonist+in+rats.&rft.au=Moghaddam%2C+B%3BAdams%2C+B+W&rft.aulast=Moghaddam&rft.aufirst=B&rft.date=1998-08-28&rft.volume=281&rft.issue=5381&rft.spage=1349&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-09-09 N1 - Date created - 1998-09-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Science. 1998 Aug 28;281(5381):1264-5 [9735037] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The failing flap in facial plastic and reconstructive surgery: role of the medicinal leech. AN - 85409754; pmid-9707230 AB - OBJECTIVE: To review the use of the medicinal leech, Hirudo medicinalis, in salvaging the failing, venous-congested flap. A protocol for the use of leeches is presented. Four illustrative cases of failing flaps (pectoralis major, midline forehead, and temporalis) are presented. STUDY DESIGN: Literature review comprised of MEDLINE search 1965 to present. Retrospective review of four cases involving the management of the failing, venous-congested flap. METHODS: A retrospective review of four cases of failing, venous-congested flaps was performed. RESULTS: The authors' experience, as well as the data from the reviewed medical literature, demonstrates the importance of early intervention in order to salvage the failing, venous-congested flap. Leeches are an immediate and efficacious treatment option. CONCLUSIONS: 1. Review of the literature indicates that the survival of the compromised, venous-congested flap is improved by early intervention with the medicinal leech. H medicinalis injects salivary components that inhibit both platelet aggregation and the coagulation cascade. The flap is decongested initially as the leech extracts blood and is further decongested as the bite wound oozes after the leech detaches. 2. When a flap begins to fail, salvage of that flap demands early recognition of reversible processes, such as venous congestion. The surgeon must be familiar with the use of leeches and should consider their use early, since flaps demonstrate significantly decreased survival after 3 hours if venous congestion is not relieved. In the four cases presented, a standardized protocol facilitated early leech use and provided for the psychological preparation of the patient, availability of leeches, and an antibiotic prophylaxis regimen. 3. The complications associated with leech use can be minimized with antibiotic therapy, wound care, and hematocrit monitoring. 4. The use of the medicinal leech for salvage of the venous-congested flap is a safe, efficacious, economical, and well-tolerated intervention. JF - The Laryngoscope AU - Utley, D S AU - Koch, R J AU - Goode, R L AD - Division of Otolaryngology/Head and Neck Surgery, Facial Plastic and Reconstructive Surgery, Stanford University Medical Center, Palo Alto Veterans Administration Health Care System, California 94305-5328, USA. utley64@leland.stanford.edu Y1 - 1998/08// PY - 1998 DA - August 1998 SP - 1129 EP - 1135 VL - 108 IS - 8 Pt 1 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Graft Survival KW - Humans KW - Retrospective Studies KW - Aged KW - Otorhinolaryngologic Surgical Procedures KW - Middle Aged KW - Reconstructive Surgical Procedures KW - Male KW - Leeches KW - Surgical Flaps KW - Face -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85409754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=The+failing+flap+in+facial+plastic+and+reconstructive+surgery%3A+role+of+the+medicinal+leech.&rft.au=Utley%2C+D+S%3BKoch%2C+R+J%3BGoode%2C+R+L&rft.aulast=Utley&rft.aufirst=D&rft.date=1998-08-01&rft.volume=108&rft.issue=8+Pt+1&rft.spage=1129&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Sensitivity of aerosol bolus behavior to methacholine-induced bronchoconstriction. AN - 85246140; pmid-9726722 AB - STUDY OBJECTIVES: Airway narrowing causes alterations in the shape of an exhaled aerosol bolus that can serve as indexes of airway changes during bronchoprovocation. We compared the sensitivities of aerosol bolus behavior and specific airway conductance (SGaw) during bronchoprovocation in normal subjects. DESIGN AND PARTICIPANTS: Fifteen normal, nonsmoking subjects were studied. Doubling methacholine (MCh) concentrations were delivered during tidal breathing. After each dose, SGaw was determined followed by inhalation of narrow pulses of 1-microm particles introduced into 1-L breaths. Inhaled and exhaled particle concentrations were measured with light scattering photometry. Using plots of concentration vs volume, the exhaled bolus was compared with the inhaled bolus for measurements of volumetric change in mode location (modal shift), particle deposition, and dispersion. To determine baseline intrasubject variability, sham studies using buffer solution were performed on five subjects. RESULTS: MCh caused a proximal modal shift, and increased dispersion and deposition of the exhaled bolus. At most doses, a greater percentage of subjects showed significant change (p<0.05) from baseline for modal shift and deposition than for SGaw. Aerosol bolus behavior displayed less intrasubject variability than did SGaw during sham studies. CONCLUSION: Aerosol bolus behavior is at least as sensitive as SGaw in detecting MCh-induced airway constriction in normal subjects and exhibits less intrasubject variability. JF - Chest AU - Hardy, K G AU - Gann, L P AU - Tennal, K B AU - Walls, R AU - Hiller, F C AU - Anderson, P J AD - Division of Pulmonary and Critical Care Medicine, John L. McClellan Veterans Administration Medical Center and the University of Arkansas for Medical Sciences, Little Rock 72205, USA. PY - 1998 SP - 404 EP - 410 VL - 114 IS - 2 SN - 0012-3692, 0012-3692 KW - Sensitivity and Specificity KW - Respiratory Function Tests KW - Aerosols KW - Reference Values KW - Bronchoconstrictor Agents KW - Bronchial Provocation Tests KW - Human KW - Comparative Study KW - Lung KW - Adult KW - Methacholine Chloride KW - Bronchoconstriction KW - Support, U.S. Gov't, Non-P.H.S. KW - Administration, Inhalation KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85246140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Sensitivity+of+aerosol+bolus+behavior+to+methacholine-induced+bronchoconstriction.&rft.au=Hardy%2C+K+G%3BGann%2C+L+P%3BTennal%2C+K+B%3BWalls%2C+R%3BHiller%2C+F+C%3BAnderson%2C+P+J&rft.aulast=Hardy&rft.aufirst=K&rft.date=1998-08-01&rft.volume=114&rft.issue=2&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Reliability and acceptability of psychiatric diagnosis via telecommunication and audiovisual technology. AN - 73855536; 9712219 AB - The reliability of psychiatric diagnoses made remotely by telecommunication was examined. Two trained interviewers each interviewed the same 30 psychiatric inpatients using the Structured Clinical Interview for DSM-III-R. Fifteen subjects had two in-person interviews, and 15 subjects had one in-person and one remote interview via telecommunication. Interrater reliability was calculated for the four most common diagnoses: major depression, bipolar disorder, panic disorder, and alcohol dependence. For each diagnosis, interrater reliability (kappa statistic) was identical or almost identical for the patients who had two in-person interviews and those who had an in-person and a remote interview, suggesting that reliable psychiatric diagnoses can be made via telecommunication. JF - Psychiatric services (Washington, D.C.) AU - Ruskin, P E AU - Reed, S AU - Kumar, R AU - Kling, M A AU - Siegel, E AU - Rosen, M AU - Hauser, P AD - Baltimore Veterans Affairs Medical Center, Maryland 21201, USA. ruskin.paul@baltimore.va.gov Y1 - 1998/08// PY - 1998 DA - August 1998 SP - 1086 EP - 1088 VL - 49 IS - 8 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - Bipolar Disorder -- diagnosis KW - Reproducibility of Results KW - Patient Satisfaction KW - Alcoholism -- diagnosis KW - Humans KW - Depressive Disorder -- diagnosis KW - Panic Disorder -- diagnosis KW - Mental Disorders -- diagnosis KW - Telemedicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73855536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Reliability+and+acceptability+of+psychiatric+diagnosis+via+telecommunication+and+audiovisual+technology.&rft.au=Ruskin%2C+P+E%3BReed%2C+S%3BKumar%2C+R%3BKling%2C+M+A%3BSiegel%2C+E%3BRosen%2C+M%3BHauser%2C+P&rft.aulast=Ruskin&rft.aufirst=P&rft.date=1998-08-01&rft.volume=49&rft.issue=8&rft.spage=1086&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-10-14 N1 - Date created - 1998-10-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Difficult, dangerous, and drug seeking: the 3D way to better patient care. AN - 73855180; 9702164 JF - American journal of public health AU - Carlson, M J AU - Baker, L H AD - Portland VA Medical Center, OR 97201, USA. michael.carlson@med.va.gov Y1 - 1998/08// PY - 1998 DA - August 1998 SP - 1250 EP - 1252 VL - 88 IS - 8 SN - 0090-0036, 0090-0036 KW - Abridged Index Medicus KW - Index Medicus KW - Patient Care Team -- trends KW - Health Services Misuse -- economics KW - Humans KW - Regional Health Planning -- economics KW - Aged KW - Oregon KW - Patient Care Planning -- trends KW - Adult KW - Middle Aged KW - Cost-Benefit Analysis -- trends KW - Patient Care Team -- economics KW - Male KW - Patient Care Planning -- economics KW - Health Services Misuse -- trends KW - Dangerous Behavior KW - Veterans -- psychology KW - Delivery of Health Care -- trends KW - Public Health -- trends KW - Substance-Related Disorders -- economics KW - Delivery of Health Care -- economics KW - Substance-Related Disorders -- rehabilitation KW - Treatment Refusal KW - Public Health -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73855180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Difficult%2C+dangerous%2C+and+drug+seeking%3A+the+3D+way+to+better+patient+care.&rft.au=Carlson%2C+M+J%3BBaker%2C+L+H&rft.aulast=Carlson&rft.aufirst=M&rft.date=1998-08-01&rft.volume=88&rft.issue=8&rft.spage=1250&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-08-20 N1 - Date created - 1998-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol screening questionnaires in women: a critical review. AN - 80010010; 9669791 AB - To describe the performance of alcohol screening questionnaires in female patients. We searched MEDLINE from 1966 to July 1997 for alcoholism or alcohol-drinking and for CAGE, AUDIT, BMAST, TWEAK, T-ACE, MAST, SMAST, or SAAST; Citations Indexes for newer screening questionnaires and those without acronyms; and MEDLINE from 1996 to July 1997 for alcoholism or alcohol-drinking and screening. Reviewed studies presented data for women comparing brief alcohol screening questionnaires with valid criterion standards for heavy drinking (> or =2 drinks per day) or alcohol abuse or dependence in US general clinical populations. Sensitivities, specificities, and areas under receiver operating characteristic curves (AUROCs) were extracted. Thirteen articles (9 studies) were reviewed. The CAGE questionnaire had AUROCs of 0.84 to 0.92 for alcohol abuse and dependence in predominantly black populations of women, but using the traditional cut point of 2 or more resulted in low sensitivities (38%-50%) in predominantly white female populations. The TWEAK and Alcohol Use Disorders Identification Test (AUDIT) questionnaires had high AUROCs (0.87-0.93) for past-year alcohol abuse or dependence in black or white women, but had sensitivities less than 80% at traditional cut points. For detecting heavy drinking, the AUDIT questionnaire had AUROCs of at least 0.87 in female primary care patients. The TWEAK and T-ACE questionnaires had higher AUROCs (0.84-0.87) than the CAGE questionnaire (0.76-0.78) for detecting heavy drinking before pregnancy was recognized in black obstetric patients. The CAGE questionnaire was relatively insensitive in predominantly white female populations. The TWEAK and AUDIT questionnaires have performed adequately in black or white women, using lower cut points than usual. JF - JAMA AU - Bradley, K A AU - Boyd-Wickizer, J AU - Powell, S H AU - Burman, M L AD - Health Services Research and Development, Medicine Service, VA Puget Sound Health Care System (Seattle Division), WA 98108, USA. bradley.katharineva@seattle.va.gov Y1 - 1998/07/08/ PY - 1998 DA - 1998 Jul 08 SP - 166 EP - 171 VL - 280 IS - 2 SN - 0098-7484, 0098-7484 KW - Abridged Index Medicus KW - Index Medicus KW - Sensitivity and Specificity KW - Mass Screening KW - ROC Curve KW - Humans KW - European Continental Ancestry Group KW - Adult KW - African Americans KW - United States -- epidemiology KW - Male KW - Female KW - Surveys and Questionnaires KW - Alcoholism -- ethnology KW - Alcoholism -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80010010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Alcohol+screening+questionnaires+in+women%3A+a+critical+review.&rft.au=Bradley%2C+K+A%3BBoyd-Wickizer%2C+J%3BPowell%2C+S+H%3BBurman%2C+M+L&rft.aulast=Bradley&rft.aufirst=K&rft.date=1998-07-08&rft.volume=280&rft.issue=2&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-07-22 N1 - Date created - 1998-07-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: ACP J Club. 1999 Jan-Feb;130(1):17 JAMA. 1998 Dec 9;280(22):1904-5 [9851461] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intestinal pseudoobstruction in acute Lyme disease: a case report AN - 807279489; 13786304 AB - We report here a case of acute Lyme disease in a 61-yr-old man who developed a facial nerve paralysis and a relentless intestinal pseudoobstruction 2 wk after the initial prodrome. Both the facial nerve paralysis and pseudoobstruction persisted for a month until the patient sought medical attention. Both lesions resolved only after treatment for Lyme disease was initiated. The temporal association of the pseudoobstruction with the somatic cranial neuropathy and the response of both to specific therapy for Lyme disease suggest that the former was likely the result of a reversible autonomic neuropathy or dysfunction.American Journal of Gastroenterology (1998) 93, 1179-1180; doi:10.1111/j.1572-0241.1998.00361.x JF - American Journal of Gastroenterology AU - Chatila, Rajaa AU - Kapadia, Cyrus R AD - [1] 1 Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut, USA [2] 2 The Connecticut Veterans Administration Health Care System, West Haven, Connecticut USA Y1 - 1998/07// PY - 1998 DA - Jul 1998 SP - 1179 EP - 1180 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 93 IS - 7 SN - 0002-9270, 0002-9270 KW - Microbiology Abstracts B: Bacteriology KW - Attention KW - Borrelia KW - Lyme disease KW - J:02400 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807279489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Gastroenterology&rft.atitle=Intestinal+pseudoobstruction+in+acute+Lyme+disease%3A+a+case+report&rft.au=Chatila%2C+Rajaa%3BKapadia%2C+Cyrus+R&rft.aulast=Chatila&rft.aufirst=Rajaa&rft.date=1998-07-01&rft.volume=93&rft.issue=7&rft.spage=1179&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/10.1111%2Fj.1572-0241.1998.00361.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Lyme disease; Borrelia DO - http://dx.doi.org/10.1111/j.1572-0241.1998.00361.x ER - TY - JOUR T1 - An ascending single-dose safety and tolerance study of an oral formulation of rabeprazole (E3810). AN - 80059986; 9701531 AB - Proton pump inhibitors such as omeprazole produce a long-lasting inhibition of gastric acid secretion associated with significant increases in plasma gastrin. Rabeprazole (E3810) is a new substituted benzimidazole H+,K+ ATPase inhibitor. It acts as an irreversible, non-competitive inhibitor of the H+,K+ ATPase and preliminary studies demonstrate that rabeprazole produces a potent and long-lasting inhibition of gastric acid secretion and a low level of hypergastrinaemia. This randomized, double-blind, placebo-controlled study was performed to further examine the effects of different single doses of rabeprazole on gastric acid secretion and serum gastrin. In this study, four groups of 10 healthy, non-smoking Helicobacter pylori-negative men (mean age 22.5 +/- 3.9 years) received single oral doses of 10, 20, 30 and 40 mg of rabeprazole. Two of the 10 volunteers in each group received placebo as part of the double-blind study design. All volunteers who entered into the study had a normal gastric acid secretory capacity as evaluated by pentagastrin challenge. Prior to administration of the first dose of test drug, volunteers underwent an inpatient 24-h measurement of baseline intragastric pH. One week later, volunteers received the test drug and again underwent an inpatient 24-h measurement of intragastric pH. During both periods, plasma samples were collected at specified intervals over 48 h and were sent for analysis of rabeprazole and gastrin levels. Administration of rabeprazole resulted in a dose-dependent increase in the duration and extent of intragastric pH elevation. The response among all volunteers receiving drug was significantly different from placebo, with greater acid inhibition occurring in the 30 and 40 mg groups. In addition, there was also a dose-related increase in plasma gastrin. The pharmacokinetics of rabeprazole were similar to those of other proton pump inhibitors with a t1/2 of between 0.7 and 1.0 h. There were no clinically significant effects on patient laboratory tests or serious adverse events. The results of this study suggest that rabeprazole is as potent as omeprazole and lansoprazole in inhibiting gastric acid secretion. JF - Alimentary pharmacology & therapeutics AU - Lew, E A AU - Barbuti, R C AU - Kovacs, T O AU - Sytnic, B AU - Humphries, T J AU - Walsh, J H AD - CURE/UCLA/Digestive Disease Research Center, Department of Medicine, West Los Angeles Veterans Administration Medical Center, Los Angeles, CA 90073, USA. Y1 - 1998/07// PY - 1998 DA - July 1998 SP - 667 EP - 672 VL - 12 IS - 7 SN - 0269-2813, 0269-2813 KW - 2-Pyridinylmethylsulfinylbenzimidazoles KW - 0 KW - Anti-Ulcer Agents KW - Benzimidazoles KW - Gastrins KW - Proton Pump Inhibitors KW - Rabeprazole KW - 32828355LL KW - Omeprazole KW - KG60484QX9 KW - Index Medicus KW - Administration, Oral KW - Area Under Curve KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Humans KW - Hydrogen-Ion Concentration KW - Half-Life KW - Adult KW - Omeprazole -- analogs & derivatives KW - Male KW - Anti-Ulcer Agents -- pharmacokinetics KW - Anti-Ulcer Agents -- adverse effects KW - Benzimidazoles -- adverse effects KW - Benzimidazoles -- administration & dosage KW - Gastrins -- blood KW - Anti-Ulcer Agents -- administration & dosage KW - Benzimidazoles -- pharmacokinetics KW - Gastric Acid -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80059986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alimentary+pharmacology+%26+therapeutics&rft.atitle=An+ascending+single-dose+safety+and+tolerance+study+of+an+oral+formulation+of+rabeprazole+%28E3810%29.&rft.au=Lew%2C+E+A%3BBarbuti%2C+R+C%3BKovacs%2C+T+O%3BSytnic%2C+B%3BHumphries%2C+T+J%3BWalsh%2C+J+H&rft.aulast=Lew&rft.aufirst=E&rft.date=1998-07-01&rft.volume=12&rft.issue=7&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=Alimentary+pharmacology+%26+therapeutics&rft.issn=02692813&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-10-20 N1 - Date created - 1998-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The uses and misuses of skepticism: epidemiology and its critics. AN - 80018570; 9672569 JF - Public health reports (Washington, D.C. : 1974) AU - Ozonoff, D AD - Boston Veterans Administration Medical Center, MA, USA. dozonoff@bu.edu PY - 1998 SP - 321 EP - 323 VL - 113 IS - 4 SN - 0033-3549, 0033-3549 KW - Carcinogens KW - 0 KW - Water Pollutants, Chemical KW - Chloroform KW - 7V31YC746X KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Maximum Allowable Concentration KW - Humans KW - United States Environmental Protection Agency KW - Epidemiology KW - Water Pollutants, Chemical -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80018570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.atitle=The+uses+and+misuses+of+skepticism%3A+epidemiology+and+its+critics.&rft.au=Ozonoff%2C+D&rft.aulast=Ozonoff&rft.aufirst=D&rft.date=1998-07-01&rft.volume=113&rft.issue=4&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Public+health+reports+%28Washington%2C+D.C.+%3A+1974%29&rft.issn=00333549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-07-29 N1 - Date created - 1998-07-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 1998 Jan;148(1):137-47 [9465273] Am J Public Health. 1992 Jul;82(7):955-63 [1535181] Comment On: Public Health Rep. 1998 Jul-Aug;113(4):312-20 [9672568] Public Health Rep. 1998 Jul-Aug;113(4):290 [9672557] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - First evidence of otoprotection against carboplatin-induced hearing loss with a two-compartment system in patients with central nervous system malignancy using sodium thiosulfate. AN - 80008144; 9655844 AB - Sodium thiosulfate (STS) provides protection against carboplatin-induced ototoxicity in an animal model. The purpose of this study was to determine the STS dose required for otoprotection, in patients with malignant brain tumors treated with carboplatin in conjunction with osmotic blood-brain barrier disruption. Twenty-nine patients received STS intravenously 2 hr after carboplatin. Doses were escalated from 4 g/m2 to 8, 12, 16 and 20 g/m2 on consecutive months. Audiologic assessment was performed at baseline and monthly. The audiograms were compared with those of 19 similarly treated historical control patients who did not receive STS. The incidence of ototoxicity in the historical control group of patients was 79% (15/19). This group had an average loss of 20.8 +/- 5.9 dB (n = 19) at 8 kHz after one treatment with carboplatin, whereas the STS treatment group lost only 3.7 +/- 2 dB (n = 15) after one treatment. This difference was statistically significant as assessed by Student's t test (P < .05). Furthermore, patients in the STS treatment group with excellent base-line hearing showed little change in hearing thresholds at 8 kHz after the second treatment (8.0 +/- 8.3 dB) (n = 5) compared with the historical control patients with excellent base-line hearing, (40.5 +/- 8.6 dB) (n = 11). Our data support that doses of 16 or 20 g/m2 of STS decrease carboplatin-induced hearing loss without central nervous system entry. Clinical demonstration of an otoprotective effect with a two-compartment system to prevent drug-induced hearing loss, while preserving central nervous system cytotoxicity, has not been reported previously. JF - The Journal of pharmacology and experimental therapeutics AU - Neuwelt, E A AU - Brummett, R E AU - Doolittle, N D AU - Muldoon, L L AU - Kroll, R A AU - Pagel, M A AU - Dojan, R AU - Church, V AU - Remsen, L G AU - Bubalo, J S AD - Oregon Health Sciences University and Veterans Administration, Portland, USA. Y1 - 1998/07// PY - 1998 DA - July 1998 SP - 77 EP - 84 VL - 286 IS - 1 SN - 0022-3565, 0022-3565 KW - Antineoplastic Agents KW - 0 KW - Blood Glucose KW - Thiosulfates KW - Carboplatin KW - BG3F62OND5 KW - sodium thiosulfate KW - HX1032V43M KW - Index Medicus KW - Blood-Brain Barrier -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Middle Aged KW - Child KW - Blood Glucose -- analysis KW - Adolescent KW - Male KW - Female KW - Brain Neoplasms -- drug therapy KW - Thiosulfates -- adverse effects KW - Hearing Disorders -- prevention & control KW - Thiosulfates -- pharmacokinetics KW - Hearing Disorders -- chemically induced KW - Thiosulfates -- therapeutic use KW - Carboplatin -- adverse effects KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80008144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=First+evidence+of+otoprotection+against+carboplatin-induced+hearing+loss+with+a+two-compartment+system+in+patients+with+central+nervous+system+malignancy+using+sodium+thiosulfate.&rft.au=Neuwelt%2C+E+A%3BBrummett%2C+R+E%3BDoolittle%2C+N+D%3BMuldoon%2C+L+L%3BKroll%2C+R+A%3BPagel%2C+M+A%3BDojan%2C+R%3BChurch%2C+V%3BRemsen%2C+L+G%3BBubalo%2C+J+S&rft.aulast=Neuwelt&rft.aufirst=E&rft.date=1998-07-01&rft.volume=286&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-08-03 N1 - Date created - 1998-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Susceptibility of heterozygous MnSOD gene-knockout mice to oxygen toxicity. AN - 79981173; 9651187 AB - Recent studies have shown that homozygous Mn superoxide dismutase (Sod2) gene-knockout mice (Sod2(-/-)) die shortly after birth with extensive myocardial injury, whereas heterozygous mutants (Sod2(+/-)) are phenotypically normal in room air. In the current study, we showed that Sod2(+/-) mice with approximately 50% of normal pulmonary MnSOD activity and normal levels of lung CuZnSOD, catalase, and glutathione peroxidase activities were not substantially more susceptible to 100% O2 toxicity than their normal Sod2(+/+) littermates. The mean (+/- SD) survival of Sod2(+/-) mice in 100% O2 was 101.4 +/- 14.8 h (n = 20) versus 103.2 +/- 11.3 h (n = 20) for Sod2(+/+) littermates (P > 0.60). In addition, Sod2(+/-) mice with approximately 50% of normal heart MnSOD activity and Sod2(+/+) mice did not develop any ultrastructural abnormalities in the myocardium at 75 h or 90 h after 100% O2 exposure. These results suggest that in mice, only 50% of MnSOD activity may be sufficient for normal resistance to 100% O2 toxicity. JF - American journal of respiratory cell and molecular biology AU - Tsan, M F AU - White, J E AU - Caska, B AU - Epstein, C J AU - Lee, C Y AD - Research and Laboratory Services, Samuel S. Stratton Department of Veterans Affairs Medical Center, Albany, NY, USA. TSAN.MIN-FU@ALBANY.VA.GOV Y1 - 1998/07// PY - 1998 DA - July 1998 SP - 114 EP - 120 VL - 19 IS - 1 SN - 1044-1549, 1044-1549 KW - Catalase KW - EC 1.11.1.6 KW - Glutathione Peroxidase KW - EC 1.11.1.9 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Space life sciences KW - Catalase -- metabolism KW - Animals KW - Glutathione Peroxidase -- metabolism KW - Heterozygote KW - Mice, Inbred C57BL KW - Mice KW - Mice, Knockout KW - Hyperoxia -- pathology KW - Oxygen -- toxicity KW - Myocardium -- pathology KW - Myocardium -- enzymology KW - Lung -- ultrastructure KW - Superoxide Dismutase -- metabolism KW - Superoxide Dismutase -- genetics KW - Myocardium -- ultrastructure KW - Lung -- enzymology KW - Lung -- pathology KW - Hyperoxia -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79981173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Susceptibility+of+heterozygous+MnSOD+gene-knockout+mice+to+oxygen+toxicity.&rft.au=Tsan%2C+M+F%3BWhite%2C+J+E%3BCaska%2C+B%3BEpstein%2C+C+J%3BLee%2C+C+Y&rft.aulast=Tsan&rft.aufirst=M&rft.date=1998-07-01&rft.volume=19&rft.issue=1&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-07-23 N1 - Date created - 1998-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Basic mechanisms of disease progression in the failing heart: the role of excessive adrenergic drive. AN - 73849798; 9715817 AB - This review examines experimental evidence that suggests that excessive adrenergic stimulation of the heart may actually contribute to the untoward natural history of congestive heart failure. The basic mechanisms for catecholamine-mediated cardiac toxicity are discussed, as well as relatively new evidence that catecholamine-mediated toxicity is the result of beta-adrenoceptor-mediated cyclic adenosine monophosphate-dependent calcium overload of the cardiac myocyte. The studies reviewed herein provide a plausible biological rationale for the use of beta-adrenergic blocking agents in patients with heart failure. JF - Progress in cardiovascular diseases AU - Mann, D L AD - Department of Medicine, Veterans Administration Medical Center, and Baylor College of Medicine, Houston, TX 77030, USA. PY - 1998 SP - 1 EP - 8 VL - 41 IS - 1 Suppl 1 SN - 0033-0620, 0033-0620 KW - Catecholamines KW - 0 KW - Receptors, Adrenergic KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Myocardium -- pathology KW - Humans KW - Disease Progression KW - Hemodynamics KW - Myocardium -- metabolism KW - Neurosecretory Systems -- physiopathology KW - Receptors, Adrenergic -- metabolism KW - Heart Failure -- etiology KW - Catecholamines -- metabolism KW - Heart Failure -- metabolism KW - Heart Failure -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73849798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+cardiovascular+diseases&rft.atitle=Basic+mechanisms+of+disease+progression+in+the+failing+heart%3A+the+role+of+excessive+adrenergic+drive.&rft.au=Mann%2C+D+L&rft.aulast=Mann&rft.aufirst=D&rft.date=1998-07-01&rft.volume=41&rft.issue=1+Suppl+1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Progress+in+cardiovascular+diseases&rft.issn=00330620&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-09-04 N1 - Date created - 1998-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of seroconversion in confirming cure of Helicobacter pylori infection AN - 16549442; 4375751 AB - Context. - The role of serologic testing to confirm cure of Helicobacter pylori infection after antimicrobial therapy is not completely defined. Objective. - To determine the utility of serologic testing in confirming cure of H pylori infection more than 1 year after therapy. Design. - A prospective, before-after interventional trial. Setting. - An outpatient clinical research laboratory in an academic, urban Veterans Affairs medical center. Participants. - Twenty-three otherwise healthy men and women with active H pylori infection demonstrated by gastric biopsy and with positive H pylori serologic findings. Intervention. - A 14-day course of bismuth, tetracycline, and metronidazole. Main Outcome Measures. - Determination of IgG serum antibodies to H pylori at baseline, 1 month, 3 months, and approximately 18 months after completion of therapy compared with serial gastric mucosal biopsy specimens with stains for H pylori and for histologic examination as the criterion standard. Results. - Fifteen (65%) of 23 subjects were cured of their H pylori infection as assessed by gastric biopsy, with elimination of gastritis; median antibody levels declined from 92.5 U/mL at baseline to undetectable levels at 18 months. The other 8 subjects (35%) were not cured and had persistent gastritis at 18 months; median antibody levels declined from 130.6 U/ml at baseline to 89.7 U/ml at 18 months. Sensitivity and specificity of seroconversion (from a positive to negative test result) in detecting cure of H pylori infection were 60% and 100%, respectively. Conclusion. - Undetectable antibody levels beyond the first year of therapy accurately confirm cure of H pylori infection in initially seropositive healthy subjects with reasonable sensitivity. JF - Journal of the American Medical Association AU - Feldman, M AU - Cryer, B AU - Lee, E AU - Peterson, W L AD - Medical Service (111), Dallas VA Medical Center, 4500 S Lancaster Rd., Dallas, TX 75216, USA, feldman.mark@dallas.va.gov Y1 - 1998/07// PY - 1998 DA - Jul 1998 SP - 363 EP - 365 VL - 280 IS - 4 SN - 0098-7484, 0098-7484 KW - man KW - Microbiology Abstracts B: Bacteriology KW - Helicobacter pylori KW - Chemotherapy KW - Seroconversion KW - Antibiotics KW - J 02846:Gastrointestinal tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16549442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Association&rft.atitle=Role+of+seroconversion+in+confirming+cure+of+Helicobacter+pylori+infection&rft.au=Feldman%2C+M%3BCryer%2C+B%3BLee%2C+E%3BPeterson%2C+W+L&rft.aulast=Feldman&rft.aufirst=M&rft.date=1998-07-01&rft.volume=280&rft.issue=4&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Helicobacter pylori; Chemotherapy; Antibiotics; Seroconversion ER - TY - JOUR T1 - CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus AN - 16518067; 4347669 AB - Bacterial DNA causes B cell proliferation, immunoglobulin secretion, and Th1-like cytokine secretion, due to unmethylated CpG dinucleotides in particular base contexts (CpG motifs), which are far more common in bacterial DNA than in vertebrate DNA. Synthetic oligodeoxynucleotides (ODN) containing CpG motifs also trigger immune activation, suggesting possible utility as vaccine enhancers. Mice systemically primed with formalin-inactivated influenza virus mixed with CpG ODN, generated virus-specific serum antibodies at titres approximately seven times higher than mice immunized without CpG; the titres were further increased following an identical second injection. To determine whether CpG could be absorbed through mucosae and enhance vaccination responses, mice were immunized intranasally (IN) with the same preparation of virus with or without CpG ODN or Escherichia coli DNA. Following IN immunization, CpG ODN or E. coli DNA promoted increased production of influenza-specific antibodies in serum, saliva and the genital tract, compared with the control groups. These studies indicate that stimulatory CpG ODN are promising new immune enhancers for vaccination applications. JF - Vaccine AU - Moldoveanu, Z AU - Love-Homan, L AU - Huang, Wen Qiang AU - Krieg, A M AD - Veterans Administration Medical Center, Iowa City, IA 52246, USA, arthur-krieg@uiowa.edu Y1 - 1998/07// PY - 1998 DA - Jul 1998 SP - 1216 EP - 1224 VL - 16 IS - 11-12 SN - 0264-410X, 0264-410X KW - DNA vaccines KW - Escherichia coli KW - Influenza virus KW - influenza virus KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - F 06807:Active immunization KW - V 22097:Immunization: Vaccines & vaccination: Human KW - W3 33345:DNA vaccines KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16518067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=CpG+DNA%2C+a+novel+immune+enhancer+for+systemic+and+mucosal+immunization+with+influenza+virus&rft.au=Moldoveanu%2C+Z%3BLove-Homan%2C+L%3BHuang%2C+Wen+Qiang%3BKrieg%2C+A+M&rft.aulast=Moldoveanu&rft.aufirst=Z&rft.date=1998-07-01&rft.volume=16&rft.issue=11-12&rft.spage=1216&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Genetic diversity among strains of Moraxella catarrhalis: analysis using multiple DNA probes and a single-locus PCR-restriction fragment length polymorphism method AN - 16463539; 4380245 AB - Moraxella (Branhamella) catarrhalis, a causative agent of otitis media, sinusitis, and exacerbation of bronchitis, has acquired widespread ability to produce beta -lactamase and can be nosocomially transmitted. The typing methods used in epidemiological analyses of M. catarrhalis are not optimal for genetic analyses. Two methods, a multiple-locus Southern blot (SB) method and a single-locus PCR-restriction fragment length polymorphism (RFLP) method, were developed and used to assess genetic diversity and potential clinical and geographic relationships in M. catarrhalis. Nine randomly cloned M. catarrhalis DNA fragments were used as probes of SBs containing DNA from 54 geographically and clinically diverse strains. For comparison, a PCR-RFLP method was developed as a quick, inexpensive, and discriminating alternative. A highly variable 3.7-kb genomic region (M46) was cloned and sequenced, and 3.5 kb of the cloned DNA was targeted for PCR amplification. DNAs from the 54 strains were subjected to PCR-RFLP. SB analysis distinguished all strains that had no apparent epidemiological linkage (40 of 54), and PCR-RFLP distinguished fewer strains (21 of 54). Epidemiologically linked strains appeared genetically identical by both methods. PCR-RFLP was compared to pulsed-field gel electrophoresis (PFGE) for 8 of the 54 strains and 23 additional strains. PCR-RFLP distinguished fewer strains than PFGE typing (16 of 31 versus 20 of 31 strains), but PCR-RFLP was more useful for inferring interstrain relatedness. Separate cluster analyses of multilocus SB and single locus PCR-RFLP data showed high genetic diversity within and across geographic locations and clinical presentations. The resultant dendrograms were not entirely concordant, but both methods often gave similar strain clusters at the terminal branches. High genetic diversity, nonconcordance of cluster analyses from different genetic loci, and shared genotypes among epidemiologically linked strains support a hypothesis of high recombination relative to spread of clones. Single-locus PCR-RFLP may be suitable for short-term epidemiological studies, but the SB data demonstrate that greater strain discrimination may be obtained by sampling variation at multiple genomic sites. JF - Journal of Clinical Microbiology AU - Walker, E S AU - Preston, R A AU - Post, JCh AU - Ehrlich, G D AU - Kalbfleisch, J H AU - Klingman, K L AD - Department of Veterans Affairs Medical Center (11C), Johnson City, P.O. Box 4000, Mountain Home, TN 37684-4000, USA, walker.elaine@mtn-home.va.gov Y1 - 1998/07// PY - 1998 DA - Jul 1998 SP - 1977 EP - 1983 VL - 36 IS - 7 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - J 02704:Enumeration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16463539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Genetic+diversity+among+strains+of+Moraxella+catarrhalis%3A+analysis+using+multiple+DNA+probes+and+a+single-locus+PCR-restriction+fragment+length+polymorphism+method&rft.au=Walker%2C+E+S%3BPreston%2C+R+A%3BPost%2C+JCh%3BEhrlich%2C+G+D%3BKalbfleisch%2C+J+H%3BKlingman%2C+K+L&rft.aulast=Walker&rft.aufirst=E&rft.date=1998-07-01&rft.volume=36&rft.issue=7&rft.spage=1977&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Physicians disciplined by a state medical board. AN - 79946176; 9634260 AB - State medical boards discipline several thousand physicians each year. Although certain subgroups, such as those disciplined for malpractice, substance use, or sexual abuse, have been studied, little is known about disciplined physicians as a group. To assess the offenses, contributing factors, and type of discipline of a consecutive series of disciplined physicians. Case-control study on publicly available data matching 375 disciplined physicians with 2 groups of control physicians, one matched solely by locale, and a second matched for sex, type of practice, and locale. All disciplined physicians publicly reported by the Medical Board of California from October 1995 through April 1997. Characteristics of disciplined physicians, offenses leading to discipline, and type of discipline. A total of 375 physicians licensed by the Medical Board of California (approximately 0.24% per year) were disciplined for 465 offenses. The most frequent causes for discipline were negligence or incompetence (34%), abuse of alcohol or other drugs (14%), inappropriate prescribing practices (11%), inappropriate contact with patients (10%), and fraud (9%). Discipline imposed was revocation of medical license (21%), actual suspension of license (13%), stayed suspension of license (45%), and reprimand (21%). Type of offense was significantly associated with severity of discipline (P=.03). In logistic regression models comparing disciplined physicians with controls matched by locale, board discipline was significantly associated with physicians' sex (odds ratio [OR] for women, 0.44; 95% confidence interval [CI], 0.28-0.70) and involvement in direct patient care (OR, 2.56; 95% CI, 1.75-3.75). In the regression model with additional matching criteria, disciplinary action was negatively associated with specialty board certification (OR, 0.42; 95% CI, 0.29-0.60) and positively associated with being in practice more than 20 years (OR, 2.02; 95% CI, 1.39-2.92). A small but substantial proportion of physicians is disciplined each year for a variety of offenses. Further study of disciplined physicians is necessary to identify physicians at high risk for offenses leading to disciplinary action and to develop effective interventions to prevent these offenses. JF - JAMA AU - Morrison, J AU - Wickersham, P AD - Department of Veterans Affairs Medical Center Coatesville, PA 19320, USA. Morrison.James@coatesville.va.gov Y1 - 1998/06/17/ PY - 1998 DA - 1998 Jun 17 SP - 1889 EP - 1893 VL - 279 IS - 23 SN - 0098-7484, 0098-7484 KW - Abridged Index Medicus KW - Bioethics KW - Index Medicus KW - Medical Board of California KW - Empirical Approach KW - Legal Approach KW - Bioethics and Professional Ethics KW - Professional Patient Relationship KW - Humans KW - Punishment KW - Specialization KW - Sex Offenses -- prevention & control KW - Sex Offenses -- statistics & numerical data KW - Logistic Models KW - Substance-Related Disorders KW - Case-Control Studies KW - Ethics, Medical KW - Medicine KW - United States -- epidemiology KW - California -- epidemiology KW - Malpractice -- statistics & numerical data KW - Female KW - Male KW - Physicians -- statistics & numerical data KW - Physicians -- classification KW - Physicians -- standards KW - Government Regulation KW - Licensure, Medical -- statistics & numerical data KW - Professional Misconduct UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79946176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Physicians+disciplined+by+a+state+medical+board.&rft.au=Morrison%2C+J%3BWickersham%2C+P&rft.aulast=Morrison&rft.aufirst=J&rft.date=1998-06-17&rft.volume=279&rft.issue=23&rft.spage=1889&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-06-26 N1 - Date created - 1998-06-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: JAMA. 1998 Jun 17;279(23):1915-6 [9634266] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NeuroSPECT findings in patients with posttraumatic anosmia: a quantitative analysis. AN - 85419304; pmid-9582179 AB - OBJECTIVE: To investigate quantitative neuroSPECT findings, particularly from orbital frontal cortex, in patients rendered totally anosmic from head injury. SETTING: Veterans Administration (VA) Medical Center. SUBJECTS: Eighteen patients with head injury resulting in severe anosmia and five normal controls. All 18 patients had sustained their head injuries at least 5 years prior to involvement in the study. MEASURES: Quantitative neuroSPECT (count density) from sagittal regions of interest (ROIs) ranging circumferentially from orbital frontal cortex to occipital pole. RESULTS: Quantitative evaluation of neuroSPECT findings for anosmic patients as a group showed substantial orbital frontal hypoperfusion compared with controls, with 67% of individual anosmic patients showing orbital frontal hypoperfusion at a level two or more standard deviations below that of the worst control subject. By contrast, there were no between-group differences for five other ROIs (inferior frontal pole, superior frontal pole, posterior superior frontal lobe, the parasagittal region, and occipital pole), and individual abnormalities were infrequent in these areas. In addition, orbital frontal count was significantly correlated with ratings of outcome, the only ROI to have such a relationship. CONCLUSIONS: Findings strongly suggest that posttraumatic anosmia and the neuropsychological deficits typically associated with posttraumatic anosmia are closely and specifically associated with hypoperfusion in orbital frontal cortex. The results also underscore the importance of posttraumatic anosmia as a clinical sign of orbital frontal damage, which is particularly important in patients with mild head injury who have normal computed tomography and magnetic resonance imaging scans. JF - The Journal of head trauma rehabilitation AU - Varney, N R AU - Bushnell, D AD - Veterans Administration Medical Center, University of Iowa, Iowa City, Iowa 52246-2208, USA. Y1 - 1998/06// PY - 1998 DA - June 1998 SP - 63 EP - 72 VL - 13 IS - 3 SN - 0885-9701, 0885-9701 KW - Index Medicus KW - National Library of Medicine KW - Sensitivity and Specificity KW - Humans KW - Adult KW - Frontal Lobe -- radionuclide imaging KW - Neuropsychological Tests KW - Female KW - Male KW - Olfaction Disorders -- etiology KW - Cerebral Cortex -- radionuclide imaging KW - Tomography, Emission-Computed, Single-Photon KW - Craniocerebral Trauma -- complications KW - Olfaction Disorders -- radionuclide imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85419304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+head+trauma+rehabilitation&rft.atitle=NeuroSPECT+findings+in+patients+with+posttraumatic+anosmia%3A+a+quantitative+analysis.&rft.au=Varney%2C+N+R%3BBushnell%2C+D&rft.aulast=Varney&rft.aufirst=N&rft.date=1998-06-01&rft.volume=13&rft.issue=3&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+head+trauma+rehabilitation&rft.issn=08859701&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Persistent dysphagia and dysphonia following cervical spine surgery. AN - 85408267; pmid-9674321 AB - Persistent dysphagia and dysphonia following anterior cervical spine surgery have been underdiagnosed. Understanding the physiologic mechanism resulting in post-surgical dysphagia and dysphonia is essential to providing appropriate treatment. Two cases of protracted dysphagia and dysphonia following left anterior cervical corpectomy were reviewed. Videofluoroscopic evaluation, videostroboscopic assessment and laryngeal nerve-conduction testing were used to determine swallowing, vocal fold and cranial nerve integrity; to assess the ability to achieve oral nutrition; and to direct therapy and surgical procedures to improve swallowing and voice. With a multidisciplinary approach, the physiologic problems of post-surgical dysphagia and dysphonia can be addressed and therapeutic and/or surgical treatments initiated promptly. JF - Ear, nose, & throat journal AU - Daniels, S K AU - Mahoney, M C AU - Lyons, G D AD - Speech Pathology Section, VA Medical Center, New Orleans, LA 70146, USA. daniels.stephanie_k@new-orleans.med.va.gov Y1 - 1998/06// PY - 1998 DA - June 1998 SP - 470 VL - 77 IS - 6 SN - 0145-5613, 0145-5613 KW - Index Medicus KW - National Library of Medicine KW - Voice Disorders -- complications KW - Voice Disorders -- diagnosis KW - Electromyography -- methods KW - Humans KW - Disease Progression KW - Middle Aged KW - Deglutition Disorders -- diagnosis KW - Fluoroscopy -- methods KW - Male KW - Deglutition Disorders -- complications KW - Cervical Vertebrae -- surgery KW - Postoperative Complications -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85408267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear%2C+nose%2C+%26+throat+journal&rft.atitle=Persistent+dysphagia+and+dysphonia+following+cervical+spine+surgery.&rft.au=Daniels%2C+S+K%3BMahoney%2C+M+C%3BLyons%2C+G+D&rft.aulast=Daniels&rft.aufirst=S&rft.date=1998-06-01&rft.volume=77&rft.issue=6&rft.spage=470&rft.isbn=&rft.btitle=&rft.title=Ear%2C+nose%2C+%26+throat+journal&rft.issn=01455613&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Observations on control of N2 and N3 neck disease in squamous cell carcinoma of the head and neck by intra-arterial chemoradiation. AN - 85404784; pmid-9628492 AB - Patients with head and neck squamous cell cancer with N2 and N3 neck disease have a poor prognosis and are at risk to fail regionally despite combined surgery and radiation. Twenty-two patients with N2 and N3 neck disease (and T3-4 primaries) were treated with intra-arterial, high-dose cisplatin (CDDP), 150 mg/m2 per week for 4 weeks, and concurrent radiation. All patients were followed for at least 2 years or until death from any cause. Twenty patients had a complete response at the primary site. Two of the 20 with a complete response later had a neck recurrence and died. Five patients with palpable nodes after treatment underwent fine-needle aspiration (FNA), one of which was positive and two suggestive of cancer. Six neck dissections were performed in this group, only two of which had positive nodes. This chemoradiation protocol may offer reasonable control of N2 and N3 neck disease in advanced head and neck squamous cell cancer. Neck dissection appeared to be necessary in only those patients with nodes 8 weeks after treatment in whom FNA was positive or suggestive of cancer. Because of the relatively small size of this series, additional accrual and monitoring of such patients is planned. JF - The Laryngoscope AU - Weisman, R A AU - Christen, R D AU - Jones, V E AU - Kerber, C W AU - Seagren, S L AU - Orloff, L A AU - Glassmeyer, S L AU - Howell, S B AU - Robbins, K T AD - Division of Otolaryngology-Head and Neck Surgery, University of California, San Diego, and the San Diego Veterans Administration Medical Center, 92103-8891, USA. Y1 - 1998/06// PY - 1998 DA - June 1998 SP - 800 EP - 805 VL - 108 IS - 6 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Magnetic Resonance Imaging KW - Infusions, Intra-Arterial KW - Neoplasm Staging KW - Combined Modality Therapy KW - Lymphatic Metastasis KW - Humans KW - Retrospective Studies KW - Aged KW - Biopsy, Needle KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Adolescent KW - Female KW - Male KW - Carcinoma, Squamous Cell -- secondary KW - Head and Neck Neoplasms -- radiotherapy KW - Head and Neck Neoplasms -- pathology KW - Carcinoma, Squamous Cell -- radiotherapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Head and Neck Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85404784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Observations+on+control+of+N2+and+N3+neck+disease+in+squamous+cell+carcinoma+of+the+head+and+neck+by+intra-arterial+chemoradiation.&rft.au=Weisman%2C+R+A%3BChristen%2C+R+D%3BJones%2C+V+E%3BKerber%2C+C+W%3BSeagren%2C+S+L%3BOrloff%2C+L+A%3BGlassmeyer%2C+S+L%3BHowell%2C+S+B%3BRobbins%2C+K+T&rft.aulast=Weisman&rft.aufirst=R&rft.date=1998-06-01&rft.volume=108&rft.issue=6&rft.spage=800&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Conference report on stroke mortality in the southeastern United States. AN - 79927141; 9622131 AB - A workshop to describe and then seek possible causes for the increased stroke mortality in the southeastern United States briefly considered 30 suspected correlates and discussed in more detail the 10 thought to be most likely. Recent age-adjusted stroke mortality rates in adults from industrialized countries reveal marked geographic differences. Age-adjusted statewide stroke mortality rates also differ, and they are higher in the Southeast than elsewhere in the United States. For five southeastern coastal states in the heart of the "Stroke Belt," excess stroke mortality has been present at least since 1930. In a 20-year follow-up of 10,000 veterans, the Stroke Belt had a 25% increase in all-cause mortality and congestive heart failure. A potential cause of increased fatal stroke included hypertension, which was more frequent in the Stroke Belt. No consistent patterns of lifestyle differences or of differences in potassium or calcium intake seemed to explain the higher rates of fatal strokes in the Stroke Belt; however, detailed investigations of smaller populations in localized areas seem warranted. Some data suggest a relationship between socioeconomic status and the Stroke Belt effect. Other differences in the Southeast that could explain, at least partially, the Stroke Belt effect include presence of soft water throughout most of the area, decreased antioxidant intake, and differences in the use of medical care and in the response to antihypertensive drugs. On the basis of available information, the three most likely explanations or partial explanations for the Stroke Belt are increased levels of blood pressure, localized differences in socioeconomic status, and toxic environmental factor(s). Two major recommendations were made: (1) to encourage both patient and caregiver to use all currently available means of decreasing morbidity and mortality by controlling blood pressures at or below normal levels and by reducing other risk factors and (2) to seek precise information about relationships of identified possible causes of increased morbidity and mortality in the Stroke Belt. JF - Hypertension (Dallas, Tex. : 1979) AU - Perry, H M AU - Roccella, E J AD - Department of Veterans Affairs and Washington University School of Medicine, St Louis, MO, USA. perry.h mitchell jr@st-louis.va.gov Y1 - 1998/06// PY - 1998 DA - June 1998 SP - 1206 EP - 1215 VL - 31 IS - 6 SN - 0194-911X, 0194-911X KW - Antihypertensive Agents KW - 0 KW - Calcium, Dietary KW - Potassium, Dietary KW - Index Medicus KW - Multicenter Studies as Topic KW - Humans KW - Calcium, Dietary -- administration & dosage KW - African Americans -- statistics & numerical data KW - Water Supply KW - European Continental Ancestry Group -- statistics & numerical data KW - Aged KW - Multivariate Analysis KW - Veterans KW - Potassium, Dietary -- administration & dosage KW - Cardiovascular Diseases -- epidemiology KW - Social Class KW - Adult KW - Antihypertensive Agents -- therapeutic use KW - Adolescent KW - Male KW - Sex Factors KW - Southeastern United States -- epidemiology KW - Hypertension -- genetics KW - Hypertension -- drug therapy KW - Socioeconomic Factors KW - Hypertension -- complications KW - Life Style KW - Risk Factors KW - Heart Failure -- epidemiology KW - Middle Aged KW - Environmental Pollution KW - United States -- epidemiology KW - Female KW - South Carolina -- epidemiology KW - Cerebrovascular Disorders -- mortality KW - Cerebrovascular Disorders -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79927141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Conference+report+on+stroke+mortality+in+the+southeastern+United+States.&rft.au=Perry%2C+H+M%3BRoccella%2C+E+J&rft.aulast=Perry&rft.aufirst=H&rft.date=1998-06-01&rft.volume=31&rft.issue=6&rft.spage=1206&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=0194911X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-06-19 N1 - Date created - 1998-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ammonia and manganese increase arginine uptake in cultured astrocytes. AN - 79832615; 9572676 AB - Recent work has suggested a possible role for nitric oxide (NO) in the development of hepatic encephalopathy (HE). In this study, we examined the effect of ammonia and manganese, factors implicated in the pathogenesis of HE, on the transport of arginine (a precursor of NO) into primary cultures of astrocytes. Treatment with 5 mM ammonia for 1-4 days produced a maximal (53%) increase in L-arginine uptake at 3 days when compared to untreated cells. Kinetic analysis following 4-day treatment with 5 mM ammonia revealed an 82% increase in the Vmax and a 61% increase in the Km value. Similar analysis with 100 microM manganese showed a 101% increase in Vmax and a 131% increase in the Km value. These results suggest that both manganese and ammonia alter L-arginine uptake by modifying the transporter for arginine. A decrease of 32% in the non-saturable component of L-arginine transport was also observed following treatment with ammonia. When cultures were treated separately with 5 mM ammonia and 100 microM manganese for 2 days, the uptake of L-arginine increased by 41% and 57%, respectively. Combined exposure led to no further increase in uptake. Our results suggest that ammonia and manganese may contribute to the pathogenesis of HE by influencing arginine transport and thus possibly NO synthesis in astrocytes. JF - Neurochemical research AU - Hazell, A S AU - Norenberg, M D AD - Laboratory of Neuropathology, Veterans Administration Medical Center, University of Miami School of Medicine, FL 33101, USA. Y1 - 1998/06// PY - 1998 DA - June 1998 SP - 869 EP - 873 VL - 23 IS - 6 SN - 0364-3190, 0364-3190 KW - Nitric Oxide KW - 31C4KY9ESH KW - Ammonia KW - 7664-41-7 KW - Arginine KW - 94ZLA3W45F KW - Index Medicus KW - Rats KW - Cerebral Cortex -- cytology KW - Animals, Newborn KW - Animals KW - Cerebral Cortex -- drug effects KW - Cerebral Cortex -- metabolism KW - Cells, Cultured KW - Manganese Poisoning KW - Arginine -- metabolism KW - Astrocytes -- drug effects KW - Ammonia -- toxicity KW - Nitric Oxide -- physiology KW - Astrocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79832615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+research&rft.atitle=Ammonia+and+manganese+increase+arginine+uptake+in+cultured+astrocytes.&rft.au=Hazell%2C+A+S%3BNorenberg%2C+M+D&rft.aulast=Hazell&rft.aufirst=A&rft.date=1998-06-01&rft.volume=23&rft.issue=6&rft.spage=869&rft.isbn=&rft.btitle=&rft.title=Neurochemical+research&rft.issn=03643190&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-05-29 N1 - Date created - 1998-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lysostaphin treatment of experimental methicillin-resistant Staphylococcus aureus aortic valve endocarditis AN - 16465933; 4380173 AB - The emergence of clinical isolates of methicillin-resistant Staphylococcus aureus with reduced susceptibility to vancomycin has prompted a search for new and novel therapeutic agents active against S. aureus. Lysostaphin, a peptidase produced by Staphylococcus simulans, specifically cleaves the glycine-glycine bonds unique to the interpeptide cross-bridge of the S. aureus cell wall. The effectiveness of various regimens of dosing with intravenous lysostaphin was compared to that of vancomycin in the rabbit model of aortic valve endocarditis caused by a clinical methicillin-resistant S. aureus isolate. All animals were treated for a total of 3 days. The most active regimen, lysostaphin given three times daily, produced sterile vegetations in 10 of 11 treated rabbits, with a mean reduction in vegetation bacterial counts of 8.5 log sub(10) CFU/g compared to the counts in the untreated controls. In contrast, vancomycin given twice daily sterilized no vegetations and reduced vegetation bacterial counts by only 4.8 log sub(10) CFU/g. Lysostaphin given once daily was less effective, reducing mean vegetation bacterial counts by only 3.6 log sub(10) CFU/g, but the combination of lysostaphin once daily and vancomycin twice daily reduced the mean vegetation bacterial density by 7.5 log sub(10) CFU/g, a result that was significantly better than that for either regimen alone (P < 0.05). Lysostaphin was well tolerated by the rabbits, with no evidence of immunological reactions following up to 9 weeks of intravenous administration. We conclude that lysostaphin given alone or in combination with vancomycin is more effective in the treatment of experimental methicillin-resistant S. aureus aortic valve endocarditis than vancomycin alone. JF - Antimicrobial Agents & Chemotherapy AU - Climo, M W AU - Patron, R L AU - Goldstein, B P AU - Archer, G L AD - McGuire Veterans Affairs Medical Center, 1201 Broad Rock Blvd., Section 111-C, Richmond, VA 23249, USA, CLIMO.MICHAEL@RICHMOND.VA.GOV Y1 - 1998/06// PY - 1998 DA - Jun 1998 SP - 1355 EP - 1360 VL - 42 IS - 6 SN - 0066-4804, 0066-4804 KW - Lysostaphin KW - Microbiology Abstracts B: Bacteriology KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16465933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Lysostaphin+treatment+of+experimental+methicillin-resistant+Staphylococcus+aureus+aortic+valve+endocarditis&rft.au=Climo%2C+M+W%3BPatron%2C+R+L%3BGoldstein%2C+B+P%3BArcher%2C+G+L&rft.aulast=Climo&rft.aufirst=M&rft.date=1998-06-01&rft.volume=42&rft.issue=6&rft.spage=1355&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Subunit stoichiometry of the epithelial sodium channel. AN - 79875384; 9593680 AB - The epithelial Na+ Channel (ENaC) mediates Na+ reabsorption in a variety of epithelial tissues. ENaC is composed of three homologous subunits, termed alpha, beta, and gamma. All three subunits participate in channel formation as the absence of any one subunit results in a significant reduction or complete abrogation of Na+ current expression in Xenopus oocytes. To determine the subunit stoichiometry, a biophysical assay was employed utilizing mutant subunits that display significant differences in sensitivity to channel blockers from the wild type channel. Our results indicate that ENaC is a tetrameric channel with an alpha2 beta gamma stoichiometry, similar to that reported for other cation selective channels, such as Kv, Kir, as well as voltage-gated Na+ and Ca2+ channels that have 4-fold internal symmetry. JF - The Journal of biological chemistry AU - Kosari, F AU - Sheng, S AU - Li, J AU - Mak, D O AU - Foskett, J K AU - Kleyman, T R AD - Departments of Medicine and Physiology, University of Pennsylvania and Veterans Administration Medical Center, Philadelphia, Pennsylvania 19104, USA. Y1 - 1998/05/29/ PY - 1998 DA - 1998 May 29 SP - 13469 EP - 13474 VL - 273 IS - 22 SN - 0021-9258, 0021-9258 KW - Recombinant Proteins KW - 0 KW - Sodium Channels KW - Index Medicus KW - Animals KW - Recombinant Proteins -- metabolism KW - Xenopus KW - Mice KW - Epithelium -- metabolism KW - Recombinant Proteins -- chemistry KW - Recombinant Proteins -- genetics KW - Mutagenesis KW - Sodium Channels -- genetics KW - Sodium Channels -- metabolism KW - Sodium Channels -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79875384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Subunit+stoichiometry+of+the+epithelial+sodium+channel.&rft.au=Kosari%2C+F%3BSheng%2C+S%3BLi%2C+J%3BMak%2C+D+O%3BFoskett%2C+J+K%3BKleyman%2C+T+R&rft.aulast=Kosari&rft.aufirst=F&rft.date=1998-05-29&rft.volume=273&rft.issue=22&rft.spage=13469&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-07-01 N1 - Date created - 1998-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Functional magnetic resonance imaging of alprazolam-induced changes in humans with familial alcoholism. AN - 73928317; 9754450 AB - This study sought to identify whether subjects with a family history (FH + ) of alcoholism had changes in regional cerebral blood volume (rCBV) after an alprazolam challenge which distinguished them from subjects without a family history (FH -) of alcoholism using functional MRI (fMRI). Twelve FH + and eight FH - subjects were challenged with 1 mg of alprazolam or placebo in a double-blind crossover design. FMRI scans were obtained at baseline, 1 and 2 h after the challenge using the dynamic susceptibility contrast method with gadolinium. Mood scales, the Tufts Addiction Research Center Inventory-Morphine Benzedrine Group Scale and the drug liking scale, were administered every 30 min to assess drug effects. Global analysis of CBV showed a treatment by time decrease on alprazolam relative to placebo, but no effect by family history. The FH + group showed rCBV decreases at 1 h in the left caudate and left inferior prefrontal region, while the FH - group showed rCBV decreases at 2 h in the right inferior prefrontal region and anterior cingulate in response to alprazolam relative to placebo. FH + subjects reported more mood enhancement with alprazolam. This fMRI technique detected global and regional CBV changes induced by alprazolam. The location and rate of alprazolam-induced rCBV changes differed between FH + and FH - subjects. These changes may be related to the increased mood enhancement found in subjects genetically predisposed to alcoholism. JF - Psychiatry research AU - Streeter, C C AU - Ciraulo, D A AU - Harris, G J AU - Kaufman, M J AU - Lewis, R F AU - Knapp, C M AU - Ciraulo, A M AU - Maas, L C AU - Ungeheuer, M AU - Szulewski, S AU - Renshaw, P F AD - Department of Psychiatry/116A, Outpatient Clinic, Boston National Institute on Drug Abuse/Veterans Administration Medication Development Research Unit, MA 02114, USA. streeter.chris@boston.va.gov Y1 - 1998/05/20/ PY - 1998 DA - 1998 May 20 SP - 69 EP - 82 VL - 82 IS - 2 SN - 0165-1781, 0165-1781 KW - Anti-Anxiety Agents KW - 0 KW - Alprazolam KW - YU55MQ3IZY KW - Index Medicus KW - Affect -- drug effects KW - Double-Blind Method KW - Humans KW - Adult KW - Cross-Over Studies KW - Male KW - Functional Laterality KW - Female KW - Echo-Planar Imaging KW - Anti-Anxiety Agents -- pharmacology KW - Brain -- blood supply KW - Alprazolam -- pharmacology KW - Alcoholism -- metabolism KW - Brain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73928317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Functional+magnetic+resonance+imaging+of+alprazolam-induced+changes+in+humans+with+familial+alcoholism.&rft.au=Streeter%2C+C+C%3BCiraulo%2C+D+A%3BHarris%2C+G+J%3BKaufman%2C+M+J%3BLewis%2C+R+F%3BKnapp%2C+C+M%3BCiraulo%2C+A+M%3BMaas%2C+L+C%3BUngeheuer%2C+M%3BSzulewski%2C+S%3BRenshaw%2C+P+F&rft.aulast=Streeter&rft.aufirst=C&rft.date=1998-05-20&rft.volume=82&rft.issue=2&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-11-25 N1 - Date created - 1998-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol-mediated increases in acetaminophen hepatotoxicity: role of CYP2E and CYP3A. AN - 79951963; 9633991 AB - This commentary focuses on the roles of CYP3A and CYP2E in alcohol-mediated increases in acetaminophen hepatotoxicity. CYP2E has been considered to be the main form of P450 responsible for such toxicity in animals and humans. However, CYP3A, which is also induced by alcohol, has been shown to have a greater affinity for acetaminophen than CYP2E. Previous experiments implicating CYP2E in alcohol-mediated increases in acetaminophen hepatotoxicity have used inhibitors of this form of P450 that are now proving to be non-specific. Triacetyloleandomycin (TAO) is a potent inhibitor of CYP3A that maintains specificity in vitro over a large concentration range. In rats treated with ethanol or the combination of ethanol and isopentanol, the major higher chain alcohol in alcoholic beverages, TAO protects animals from increases in acetaminophen hepatotoxicity, suggesting a major role of CYP3A. CYP2E may not have a major role due to the rapid loss of induced levels in the absence of continued exposure to ethanol. Knockout mice, which are being used to define the role of particular proteins in biological responses, have been developed for CYP2E1 and CYP1A2 but not CYP3A. Cyp2e1(-/-) and Cyp1a2(-/-) mice are more resistant to acetaminophen hepatotoxicity than wild-type strains, even though the amounts of the other forms of P450s are unaltered in the liver. These findings suggest that the relative amounts of P450s and not just kinetic characteristics determine their role in acetaminophen hepatotoxicity. The clinical implications of the findings that CYP3A can have a major role in acetaminophen-mediated hepatotoxicity are discussed. JF - Biochemical pharmacology AU - Sinclair, J AU - Jeffery, E AU - Wrighton, S AU - Kostrubsky, V AU - Szakacs, J AU - Wood, S AU - Sinclair, P AD - Veterans Administration Medical Center, White River Junction, VT 05009, USA. Y1 - 1998/05/15/ PY - 1998 DA - 1998 May 15 SP - 1557 EP - 1565 VL - 55 IS - 10 SN - 0006-2952, 0006-2952 KW - Cytochrome P-450 CYP2E1 Inhibitors KW - 0 KW - Cytochrome P-450 Enzyme Inhibitors KW - Enzyme Inhibitors KW - Acetaminophen KW - 362O9ITL9D KW - Ethanol KW - 3K9958V90M KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP3A KW - Oxidoreductases, N-Demethylating KW - EC 1.5.- KW - Index Medicus KW - Animals KW - Substance Withdrawal Syndrome KW - Biotransformation KW - Enzyme Inhibitors -- pharmacology KW - Drug Synergism KW - Ethanol -- adverse effects KW - Acetaminophen -- pharmacokinetics KW - Liver -- drug effects KW - Ethanol -- pharmacology KW - Acetaminophen -- adverse effects KW - Cytochrome P-450 Enzyme System -- metabolism KW - Oxidoreductases, N-Demethylating -- antagonists & inhibitors KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Oxidoreductases, N-Demethylating -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79951963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Alcohol-mediated+increases+in+acetaminophen+hepatotoxicity%3A+role+of+CYP2E+and+CYP3A.&rft.au=Sinclair%2C+J%3BJeffery%2C+E%3BWrighton%2C+S%3BKostrubsky%2C+V%3BSzakacs%2C+J%3BWood%2C+S%3BSinclair%2C+P&rft.aulast=Sinclair&rft.aufirst=J&rft.date=1998-05-15&rft.volume=55&rft.issue=10&rft.spage=1557&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-07-02 N1 - Date created - 1998-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Activation of NF- Kappa B via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells AN - 16511996; 4290295 AB - Cystic fibrosis (CF) is an autosomal recessive disorder, the most common lethal genetic disease in Caucasians. Respiratory disease is the major cause of morbidity and mortality. Indeed, 95% of CF patients die of respiratory failure. Pseudomonas aeruginosa, an opportunistic pathogen, chronically infects the lungs of over 85% of CF patients. It is ineradicable by antibiotics and responsible for airway mucus overproduction that contributes to airway obstruction and death. The molecular mechanisms underlying this pathology are unknown. Here we show that P. aeruginosa activates a c-Src-Ras-MEK1/2-MAPK-pp90rsk signaling pathway that leads to activation of nuclear factor NF- Kappa B (p65/p50). Activated NF- Kappa B binds to a Kappa B site in the 5'-flanking region of the MUC2 gene and activates MUC2 mucin transcription. These studies bring new insight into bacterial-epithelial interactions and more specifically into the molecular pathogenesis of cystic fibrosis. Understanding these signaling and gene regulatory mechanisms opens up new therapeutic targets for cystic fibrosis. JF - Proceedings of the National Academy of Sciences, USA AU - Li, J AU - Feng, W AU - Gallup, M AU - Kim, J AU - Gum, J AU - Kim, Y AU - Basbaum, C AD - Department of Anatomy, Program in Biomedical Sciences, and Cardiovascular Research Institute, Metabolic Research Unit, and Department of Medicine and Veterans Administration Medical Center, University of California, San Francisco, CA 94143, cbas@itsa.ucsf.edu Y1 - 1998/05/12/ PY - 1998 DA - 1998 May 12 SP - 5718 EP - 5723 VL - 95 IS - 10 SN - 0027-8424, 0027-8424 KW - MAPK kinase KW - MEK1 proein KW - MUC2 gene KW - NF- Kappa B protein KW - Ras protein KW - c-Src protein KW - mucin KW - mucins KW - rsk protein KW - transmembrane conductance regulator KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16511996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Activation+of+NF-+Kappa+B+via+a+Src-dependent+Ras-MAPK-pp90rsk+pathway+is+required+for+Pseudomonas+aeruginosa-induced+mucin+overproduction+in+epithelial+cells&rft.au=Li%2C+J%3BFeng%2C+W%3BGallup%2C+M%3BKim%2C+J%3BGum%2C+J%3BKim%2C+Y%3BBasbaum%2C+C&rft.aulast=Li&rft.aufirst=J&rft.date=1998-05-12&rft.volume=95&rft.issue=10&rft.spage=5718&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Incidence and severity of acute allograft rejection in liver transplant recipients treated with alfa interferon AN - 902337130; 11807127 AB - Interferon alfa-2b (IFN-) therapy has been shown to be effective in the treatment of viral hepatitis B (HBV) or viral hepatitis C (HCV) in patients who did not undergo transplantation. However, in allograft recipients, treatment with IFN- often leads to allograft rejection. The aim of the present study was to determine if IFN- therapy increases the incidence or severity of acute rejection in human liver allograft recipients. One hundred five orthotopic liver transplant (OLT) recipients with HBV (n = 32), HCV (n = 58), or Non A Non B Non C (n = 15) viral infections were treated with a 6-month course of IFN-, 5 million U subcutaneously three times a week, which began 2 to 97 months after transplantation. The mean hepatitis activity index (HAI) at the beginning of the therapy was 10.1 ± 3.0. The baseline immunosuppression was achieved by tacrolimus in 77 patients and by cyclosporine A (CyA) in 28 patients. Contemporaneous controls consisted of 132 OLT patients (100 who received tacrolimus and 32 who received CyA) who did not receive IFN-. A retrospective analysis was performed on this group of patients. The incidence of rejection and the baseline immunosuppression were compared. All biopsies were reviewed without knowledge of clinical data and scored for HAI and for rejection activity index (RAI). The biochemical response to IFN- was also examined. The mean baseline maintenance dose of prednisone was greater by 2 mg daily in patients who received IFN- with tacrolimus compared with control patients who did not receive IFN- with tacrolimus (IFN- 5.3 ± 5.2 mg daily vcontrols 3.3 ± 4.9 mg daily; P .05). Similarly, the mean maintenance dose of prednisone was greater by 2.5 mg daily in patients who received IFN- compared with controls who received CyA-based immunosuppression (IFN- 9.8 ± 3.1 mg daily vcontrols 7.3 ± 3.3 mg daily; P= .01). Acute rejection episodes were detected in 10.5% (n = 11) of IFN-treated patients compared with 8.8% of controls for the similar time period from OLT and period of exposure to risk of rejection. Mean RAI was 2.0 ± 2.4 for the IFN-treated group and 2.1 ± 1.7 for controls. Rejection episodes with IFN- treatment were mild and responded to steroid therapy. In OLT recipients, the risk of acute rejection was not increased by the introduction of IFN-. However, in this study, patients were exposed to greater levels of immunosuppression. JF - Liver Transplantation AU - Ashokkumar Jain, AU - Demetris, Anthony J AU - Manez, Rafael AU - Tsamanadas, Athanassisos C AU - Van Thiel, David AU - Rakela, Jorge AU - Starzl, Thomas E AU - Fung, John J AD - Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center and the Veterans Administration Medical Center, Pittsburgh, PA Y1 - 1998/05// PY - 1998 DA - May 1998 SP - 197 EP - 203 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 4 IS - 3 SN - 1527-6465, 1527-6465 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Biopsy KW - Cyclosporins KW - Data processing KW - Graft rejection KW - Hepatitis B KW - Hepatitis C KW - Immunosuppression KW - Infection KW - Interferon KW - Liver transplantation KW - Prednisone KW - Steroid hormones KW - Tacrolimus KW - Hepatitis B virus KW - Hepatitis C virus KW - W 30940:Products KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902337130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Liver+Transplantation&rft.atitle=Incidence+and+severity+of+acute+allograft+rejection+in+liver+transplant+recipients+treated+with+alfa+interferon&rft.au=Ashokkumar+Jain%2C%3BDemetris%2C+Anthony+J%3BManez%2C+Rafael%3BTsamanadas%2C+Athanassisos+C%3BVan+Thiel%2C+David%3BRakela%2C+Jorge%3BStarzl%2C+Thomas+E%3BFung%2C+John+J&rft.aulast=Ashokkumar+Jain&rft.aufirst=&rft.date=1998-05-01&rft.volume=4&rft.issue=3&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Liver+Transplantation&rft.issn=15276465&rft_id=info:doi/10.1002%2Flt.500040315 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-01-25 N1 - SubjectsTermNotLitGenreText - Prednisone; Data processing; Graft rejection; Biopsy; Tacrolimus; Steroid hormones; Infection; Cyclosporins; Liver transplantation; Interferon; Hepatitis B; Hepatitis C; Immunosuppression; Hepatitis C virus; Hepatitis B virus DO - http://dx.doi.org/10.1002/lt.500040315 ER - TY - JOUR T1 - Regional cerebral blood flow during acute and chronic abstinence from combined cocaine-alcohol abuse. AN - 79978023; 9649971 AB - Regional cerebral blood flow (rCBF) was assessed using SPECT and HMPAO in ten cocaine abusers within 72 h of last cocaine use and then after 21 days of abstinence. In comparison to normals the cocaine abusers had significantly reduced rCBF in 11 of 14 brain regions with the largest reductions in the frontal and parietal cortex and greater rCBF in the brain stem. These perfusion defects appeared to be primarily due to combined alcohol and cocaine abuse and frontal but not parietal defects appeared to resolve partially during 21 days of abstinence. JF - Drug and alcohol dependence AU - Kosten, T R AU - Cheeves, C AU - Palumbo, J AU - Seibyl, J P AU - Price, L H AU - Woods, S W AD - Division of Substance Abuse, Yale University School of Medicine, New Haven, CT, USA. Kosten.Thomas_R@West-Haven.VA.Gov Y1 - 1998/05/01/ PY - 1998 DA - 1998 May 01 SP - 187 EP - 195 VL - 50 IS - 3 SN - 0376-8716, 0376-8716 KW - Central Nervous System Depressants KW - 0 KW - Central Nervous System Stimulants KW - Vasoconstrictor Agents KW - Ethanol KW - 3K9958V90M KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Drug Interactions KW - Tomography, Emission-Computed, Single-Photon KW - Frontal Lobe -- drug effects KW - Brain -- blood supply KW - Brain -- drug effects KW - Frontal Lobe -- diagnostic imaging KW - Humans KW - Parietal Lobe -- blood supply KW - Longitudinal Studies KW - Brain -- diagnostic imaging KW - Frontal Lobe -- blood supply KW - Remission, Spontaneous KW - Single-Blind Method KW - Parietal Lobe -- diagnostic imaging KW - Adult KW - Case-Control Studies KW - Temperance KW - Time Factors KW - Male KW - Female KW - Parietal Lobe -- drug effects KW - Ethanol -- adverse effects KW - Substance Withdrawal Syndrome -- physiopathology KW - Central Nervous System Depressants -- adverse effects KW - Cerebrovascular Circulation -- drug effects KW - Vasoconstrictor Agents -- adverse effects KW - Central Nervous System Stimulants -- adverse effects KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79978023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Regional+cerebral+blood+flow+during+acute+and+chronic+abstinence+from+combined+cocaine-alcohol+abuse.&rft.au=Kosten%2C+T+R%3BCheeves%2C+C%3BPalumbo%2C+J%3BSeibyl%2C+J+P%3BPrice%2C+L+H%3BWoods%2C+S+W&rft.aulast=Kosten&rft.aufirst=T&rft.date=1998-05-01&rft.volume=50&rft.issue=3&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-09-28 N1 - Date created - 1998-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hydromorphone-naloxone combinations in opioid-dependent humans under a naloxone novel-response discrimination procedure. AN - 79911334; 9608349 AB - Naloxone-hydromorphone combinations were tested in participants trained to discriminate naloxone from placebo under a novel-response drug discrimination procedure while maintained on methadone. Naloxone alone produced dose-related increases in naloxone-appropriate responding, little or no "novel"-appropriate responding, and increases in opioid antagonist adjective ratings (n = 5). Hydromorphone alone produced dose-related increases in novel-appropriate responding, little or no naloxone-appropriate responding, and increases in opioid agonist adjective ratings (n = 6). When combined with naloxone, hydromorphone produced dose-related decreases in naloxone-appropriate responding and antagonist adjective ratings (n = 6). These findings are consistent with nonhuman data and suggest that this procedure may be useful as a human laboratory model of opioid withdrawal. JF - Experimental and clinical psychopharmacology AU - Oliveto, A H AU - Rosen, M I AU - Kosten, T A AU - Hameedi, F A AU - Woods, S W AU - Kosten, T R AD - Department of Psychiatry, Yale University School of Medicine, USA. oliveto.alison_h@west-haven.va.gov Y1 - 1998/05// PY - 1998 DA - May 1998 SP - 169 EP - 178 VL - 6 IS - 2 SN - 1064-1297, 1064-1297 KW - Naloxone KW - 36B82AMQ7N KW - Hydromorphone KW - Q812464R06 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Methadone -- therapeutic use KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Male KW - Female KW - Discrimination Learning -- drug effects KW - Naloxone -- administration & dosage KW - Opioid-Related Disorders -- psychology KW - Hydromorphone -- administration & dosage KW - Opioid-Related Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79911334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Hydromorphone-naloxone+combinations+in+opioid-dependent+humans+under+a+naloxone+novel-response+discrimination+procedure.&rft.au=Oliveto%2C+A+H%3BRosen%2C+M+I%3BKosten%2C+T+A%3BHameedi%2C+F+A%3BWoods%2C+S+W%3BKosten%2C+T+R&rft.aulast=Oliveto&rft.aufirst=A&rft.date=1998-05-01&rft.volume=6&rft.issue=2&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-07-30 N1 - Date created - 1998-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clozapine for dopaminergic-induced paraphilias in Parkinson's disease. AN - 79906583; 9613761 JF - Movement disorders : official journal of the Movement Disorder Society AU - Fernandez, H H AU - Durso, R AD - Department of Neurology, Boston University School of Medicine, Boston Veterans Administration Medical Center, Massachusetts, USA. Y1 - 1998/05// PY - 1998 DA - May 1998 SP - 597 EP - 598 VL - 13 IS - 3 SN - 0885-3185, 0885-3185 KW - Antipsychotic Agents KW - 0 KW - Pergolide KW - 24MJ822NZ9 KW - Clozapine KW - J60AR2IKIC KW - Carbidopa KW - MNX7R8C5VO KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Aged, 80 and over KW - Humans KW - Aged KW - Male KW - Pergolide -- adverse effects KW - Carbidopa -- administration & dosage KW - Paraphilic Disorders -- chemically induced KW - Clozapine -- therapeutic use KW - Antipsychotic Agents -- therapeutic use KW - Pergolide -- administration & dosage KW - Paraphilic Disorders -- drug therapy KW - Carbidopa -- adverse effects KW - Clozapine -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Parkinson Disease -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79906583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Clozapine+for+dopaminergic-induced+paraphilias+in+Parkinson%27s+disease.&rft.au=Fernandez%2C+H+H%3BDurso%2C+R&rft.aulast=Fernandez&rft.aufirst=H&rft.date=1998-05-01&rft.volume=13&rft.issue=3&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-08-10 N1 - Date created - 1998-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase I trial of retinoic acid and cis-platinum for advanced squamous cell cancer of the head and neck based on experimental evidence of drug synergism. AN - 79869399; 9591856 AB - Cis-platinum and 13-cis-retinoic acid have received much attention in the treatment of head and neck squamous cell cancer. Even though they have different mechanisms of action, little information is available on their interaction. This paper reviews experimental evidence for retinoic acid-cis-platinum synergy and presents toxicity data from patients with stage IV head and neck squamous cell cancer participating in a phase I trial combining 13-cis-retinoic acid and cis-platinum. Patients were given 13-cis-retinoic acid orally daily for 7 days before and daily during high-dose (150 mg/m2 per week for 4 weeks) intraarterial cis-platinum treatment with concurrent radiation. Toxicity was scored with use of the cancer and leukemia group B scale. In the phase I clinical trial, 15 patients were treated to determine a maximum tolerated dosage for 13-cis-retinoic acid of 20 mg/day. Grade 4 hematologic toxicity was dose limiting in 3 of 8 patients treated with 40 mg/day and in 1 patient treated with 60 mg/day. There were no deaths caused by toxicity; 12 of the 15 patients received all four weekly doses and the remaining 3 received three doses. Of 10 patients with fully evaluable data, all achieved a complete response at the primary site and 9 had a complete response in the neck. One patient had persistent neck disease after chemoradiation, and this tumor was removed with neck dissection. 13-Cis-retinoic acid and cis-platinum are strongly synergistic against head and neck squamous cell cancer in vitro. Pretreatment with retinoic acid results in stronger synergy than concurrent drug exposure alone. Preliminary clinical experience with combined retinoic acid and cis-platinum in a design that parallels the in vitro study indicates that toxicity is acceptable with 13-cis-retinoic acid dosages of 20 mg/day in a high-dose-intensity intraarterial chemoradiation regimen. JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery AU - Weisman, R A AU - Christen, R AU - Los, G AU - Jones, V AU - Kerber, C AU - Seagren, S AU - Glassmeyer, S AU - Orloff, L A AU - Wong, W AU - Kirmani, S AU - Howell, S AD - Department of Surgery, University of California, San Diego, San Diego Veterans Administration Medical Center, USA. Y1 - 1998/05// PY - 1998 DA - May 1998 SP - 597 EP - 602 VL - 118 IS - 5 SN - 0194-5998, 0194-5998 KW - Antineoplastic Agents KW - 0 KW - Isotretinoin KW - EH28UP18IF KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Administration, Oral KW - Drug Administration Schedule KW - Neoplasm Staging KW - Injections, Intra-Arterial KW - Humans KW - Aged KW - Radiotherapy, Adjuvant KW - Survival Rate KW - Adult KW - Cohort Studies KW - Treatment Outcome KW - Middle Aged KW - Drug Synergism KW - Female KW - Male KW - Remission Induction KW - Antineoplastic Agents -- administration & dosage KW - Head and Neck Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Head and Neck Neoplasms -- drug therapy KW - Antineoplastic Agents -- adverse effects KW - Cisplatin -- administration & dosage KW - Isotretinoin -- administration & dosage KW - Carcinoma, Squamous Cell -- surgery KW - Carcinoma, Squamous Cell -- pathology KW - Isotretinoin -- adverse effects KW - Head and Neck Neoplasms -- radiotherapy KW - Cisplatin -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Head and Neck Neoplasms -- surgery KW - Carcinoma, Squamous Cell -- drug therapy KW - Carcinoma, Squamous Cell -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79869399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=Phase+I+trial+of+retinoic+acid+and+cis-platinum+for+advanced+squamous+cell+cancer+of+the+head+and+neck+based+on+experimental+evidence+of+drug+synergism.&rft.au=Weisman%2C+R+A%3BChristen%2C+R%3BLos%2C+G%3BJones%2C+V%3BKerber%2C+C%3BSeagren%2C+S%3BGlassmeyer%2C+S%3BOrloff%2C+L+A%3BWong%2C+W%3BKirmani%2C+S%3BHowell%2C+S&rft.aulast=Weisman&rft.aufirst=R&rft.date=1998-05-01&rft.volume=118&rft.issue=5&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-06-02 N1 - Date created - 1998-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Marital Equality: What Does It Mean? AN - 61602062; 9815727 AB - Married men & women's perceptions of & adherence to marital equality are investigated to identify explanations for the discrepancy between men & women's beliefs in egalitarian relationships & the persistence of marital inequality in contemporary relationships. During structured interviews, 41 white, middle-/upper-middle-class respondents in dual-career marriages living in or near major northeastern metropolitan areas provided information about demographics, attitudes toward marital equality, household task division, reciprocity & commitment, decision making, economic resources, the influence of children, & the benefits & consequences of egalitarian marriages. Though male & female respondents advocated marital equality as ideal & as significant within their respective marriages, women indicated that relationship equality was less important to men than men's perceptions of equality; men perceived marital egalitarianism as more important to women than female respondents indicated. A majority of male & female respondents perceived marital equality as advantageous to both genders, but a significant minority emphasized marriage's costs to men & benefits to women. 2 Tables, 32 References. Adapted from the source document. JF - Journal of Family Issues AU - Rosenbluth, Susan C AU - Steil, Janice M AU - Whitcomb, Juliet H AD - Dept Veterans' Affairs Medical Center Psychology Service, 630/116B 423 East 23rd St New York NY 10010 tel: 212-686-7500; fax: 212-951-6357; ,susan@forum.va.gov rosenbluth Y1 - 1998/05// PY - 1998 DA - May 1998 SP - 227 EP - 244 VL - 19 IS - 3 SN - 0192-513X, 0192-513X KW - Marital Relations KW - Dual Career Family KW - Middle Class KW - Perceptions KW - Marriage KW - Whites KW - Sexual Inequality KW - Housework KW - Sex Differences KW - Beliefs KW - Sexual Division of Labor KW - Equality KW - Spouses KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61602062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Issues&rft.atitle=Marital+Equality%3A+What+Does+It+Mean%3F&rft.au=Rosenbluth%2C+Susan+C%3BSteil%2C+Janice+M%3BWhitcomb%2C+Juliet+H&rft.aulast=Rosenbluth&rft.aufirst=Susan&rft.date=1998-05-01&rft.volume=19&rft.issue=3&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Issues&rft.issn=0192513X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JFISDT N1 - SubjectsTermNotLitGenreText - Sexual Inequality; Spouses; Equality; Marital Relations; Perceptions; Beliefs; Sex Differences; Dual Career Family; Sexual Division of Labor; Whites; Middle Class; Housework; Marriage ER - TY - JOUR T1 - Long and Short Forms of the Speech-Sounds Perception Test: Item Analysis and Age and Education Corrections AN - 58375952; 9902006 AB - An item analysis of the long & short forms of the Speech-Sounds Perception Test (SSPT) was conducted on the following groups: normal controls, two groups of diffusely brain-damaged patients, & a heterogenous group of patients sent for neuropsychological assessment (total N = 632). It is largely the % of correct responses on the SSPT items that differentiate the groups. The discrimination indices showed that 83% of the test items are good. A regression equation for estimating the long-form SSPT from the short-form SSPT is provided along with age- & education-correction for the SSPT long & short forms. 9 References. Adapted from the source document JF - The Clinical Neuropsychologist AU - Charter, Richard A AU - Dobbs, Sharon M AD - Dept Veterans Affairs Medical Center, Long Beach CA 90822 charter,richarda@long-beach.VA.gov Y1 - 1998/05// PY - 1998 DA - May 1998 SP - 213 EP - 216 VL - 12 IS - 2 SN - 1385-4046, 1385-4046 KW - Speech Perception (82700) KW - Brain Damage (09400) KW - Speech Tests (83100) KW - article KW - 6910: psychometrics; psychometrics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58375952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Clinical+Neuropsychologist&rft.atitle=Long+and+Short+Forms+of+the+Speech-Sounds+Perception+Test%3A+Item+Analysis+and+Age+and+Education+Corrections&rft.au=Charter%2C+Richard+A%3BDobbs%2C+Sharon+M&rft.aulast=Charter&rft.aufirst=Richard&rft.date=1998-05-01&rft.volume=12&rft.issue=2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=The+Clinical+Neuropsychologist&rft.issn=13854046&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CLNEEC N1 - SubjectsTermNotLitGenreText - Speech Tests (83100); Speech Perception (82700); Brain Damage (09400) ER - TY - JOUR T1 - Stages of Lexical Retrieval AN - 85517649; 200004532 AB - Beginning with a consideration of visual confrontation naming, models requiring an intervening construct between semantic input & phonological access are distinguished from those which permit direct activation of phonology on visual identification of a picture. Discrete stage models are also distinguished from nondiscrete models. In considering how various types of aphasic naming errors may be reconciled with different models of naming, it was concluded that semantic substitutions are readily accommodated by a variety of models, but that phonological errors of the type characteristic of aphasics are most easily dealt with by spreading activation models. A discussion of lexical access in free discourse emphasized not only the absence of any stages related to visual processing, but the different character of the semantic activity that leads to phonological activation in running speech, in contrast to the canonical semantic representations of picture naming & naming to description. 37 References. Adapted from the source document JF - Aphasiology AU - Goodglass, Harold AD - Veterans Administration Medical Center, Boston, MA Y1 - 1998/04// PY - 1998 DA - April 1998 SP - 287 EP - 298 VL - 12 IS - 4-5 SN - 0268-7038, 0268-7038 KW - Aphasia (03400) KW - Phonological Processing (65110) KW - Language Pathology (43250) KW - Lexical Access (46630) KW - article KW - 4016: psycholinguistics; verbal learning: paired associate, serial learning, memory, recognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85517649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Stages+of+Lexical+Retrieval&rft.au=Goodglass%2C+Harold&rft.aulast=Goodglass&rft.aufirst=Harold&rft.date=1998-04-01&rft.volume=12&rft.issue=4-5&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - Lexical Access (46630); Phonological Processing (65110); Aphasia (03400); Language Pathology (43250) ER - TY - JOUR T1 - The development of dysplasia and adenocarcinoma during endoscopic surveillance of Barrett's esophagus. AN - 85420586; pmid-9576444 AB - OBJECTIVE: Periodic endoscopic surveillance is generally recommended for patients with Barrett's esophagus. The optimal follow-up strategy for uncomplicated Barrett's esophagus is controversial, in part because of limited data on the rate of neoplastic progression (through the sequence of metaplasia-dysplasia-carcinoma) during endoscopic surveillance. This study aims to quantify the development of dysplasia in patients with uncomplicated Barrett's esophagus and to explore clinical risk factors associated with the development of dysplastic lesions. METHODS: We identified 102 patients with endoscopic evidence of Barrett's esophagus and the presence of specialized columnar epithelium who had received endoscopic surveillance for adenocarcinoma at our medical center between 1970 and 1994. We abstracted endoscopic and histologic data from the medical record. All specimens that showed any degree of atypia (per report) were reexamined in blinded fashion by a team of study pathologists who indicated the grade of dysplasia. Time to first diagnosis of dysplasia was plotted using Kaplan-Meier survival curves, and risk factors for development of dysplasia were assessed using Cox regression. RESULTS: During 563 patient-yr of endoscopic follow-up, three patients developed adenocarcinoma at least 4 yr after initial diagnosis (one developed adenocarcinoma of the cardia, which was incidentally detected during surveillance for Barrett's esophagus). At some point during follow-up, 19 patients developed new onset, low grade dysplasia and four developed high grade dysplasia. None of the patients who had received antireflux surgery developed dysplasia. CONCLUSION: If confirmed by larger follow-up studies, our results suggest that surveillance endoscopy can be safely deferred for at least 2 yr following an initial biopsy that is negative or indeterminate for dysplasia. Adoption of this approach would substantially reduce the cost of surveillance for adenocarcinoma. Future trials should explore the role of antireflux surgery in protecting against neoplastic transformation of Barrett's esophagus. JF - The American journal of gastroenterology AU - Katz, D AU - Rothstein, R AU - Schned, A AU - Dunn, J AU - Seaver, K AU - Antonioli, D AD - Department of Medicine, Veterans Administration Medical Center, White River Junction, Vermont, USA. Y1 - 1998/04// PY - 1998 DA - April 1998 SP - 536 EP - 541 VL - 93 IS - 4 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Survival Rate KW - Gastroesophageal Reflux -- surgery KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Barrett Esophagus -- complications KW - Barrett Esophagus -- pathology KW - Adenocarcinoma -- etiology KW - Barrett Esophagus -- mortality KW - Esophageal Neoplasms -- etiology KW - Esophagoscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85420586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=The+development+of+dysplasia+and+adenocarcinoma+during+endoscopic+surveillance+of+Barrett%27s+esophagus.&rft.au=Katz%2C+D%3BRothstein%2C+R%3BSchned%2C+A%3BDunn%2C+J%3BSeaver%2C+K%3BAntonioli%2C+D&rft.aulast=Katz&rft.aufirst=D&rft.date=1998-04-01&rft.volume=93&rft.issue=4&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Nasal flow volume loop as measurement of response to intranasal drug therapy. AN - 85420379; pmid-9581395 JF - Ear, nose, & throat journal AU - Baum, M B AU - Koyal, S N AU - Klaustermeyer, W B AD - Allergy and Immunology Section, West Los Angeles Veterans Administration Medical Center, Los Angeles, California 90073, USA. Y1 - 1998/04// PY - 1998 DA - April 1998 SP - 286 EP - 288 VL - 77 IS - 4 SN - 0145-5613, 0145-5613 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Aged KW - Forced Expiratory Volume KW - Glucocorticoids KW - Masks KW - Equipment Design KW - Pulmonary Ventilation KW - Administration, Intranasal KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Male KW - Female KW - Rhinitis, Allergic, Perennial -- drug therapy KW - Triamcinolone -- administration & dosage KW - Spirometry -- instrumentation KW - Beclomethasone -- administration & dosage KW - Anti-Inflammatory Agents -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85420379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear%2C+nose%2C+%26+throat+journal&rft.atitle=Nasal+flow+volume+loop+as+measurement+of+response+to+intranasal+drug+therapy.&rft.au=Baum%2C+M+B%3BKoyal%2C+S+N%3BKlaustermeyer%2C+W+B&rft.aulast=Baum&rft.aufirst=M&rft.date=1998-04-01&rft.volume=77&rft.issue=4&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Ear%2C+nose%2C+%26+throat+journal&rft.issn=01455613&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The reliability of a self-reported measure of disease, impairment, and function in persons with spinal cord dysfunction. AN - 85225330; pmid-9552102 AB - OBJECTIVE: To develop a self-report instrument that would provide information about the different levels of the disablement process, and that (1) was suitable for persons with spinal cord disease (SCD), (2) could be completed quickly, (3) could be mailed, (4) had acceptable reliability, and (5) would be clinically useful. STUDY DESIGN: Test-retest using a convenience sample. METHODS: Review of the literature and an expert panel were used to develop the instrument. It was mailed to 49,458 individuals in June 1995 and a second mailing was done in August 1995. A subset of 725 individuals who responded to both mailings was used to examine the instrument's test-retest reliability. RESULTS: The instrument has a 4th grade reading level and has questions on causal disease, disease severity, impairment, activities of daily living (including a self-reported version of the Functional Independence Measure, the SRFM), and resource utilization. Individual item test-retest reliability was high for a mailed questionnaire; all kappa coefficients were near or above .60 and most were over .70. Intraclass correlation coefficient for the SRFM was .90 and internal consistency (Chronbach's alpha) was .96. CONCLUSION: This instrument provides a new, rapid way to obtain information relative to the differing levels of the disablement process. JF - Archives of Physical Medicine and Rehabilitation AU - Hoenig, H AU - McIntyre, L AU - Sloane, R AU - Branch, L G AU - Truncali, A AU - Horner, R D AD - Durham Veterans Administration Medical Center and Duke University Medical Center, NC 27705, USA. PY - 1998 SP - 378 EP - 387 VL - 79 IS - 4 SN - 0003-9993, 0003-9993 KW - Spinal Cord Injuries KW - Questionnaires KW - Support, U.S. Gov't, P.H.S. KW - Reproducibility of Results KW - Spinal Cord Diseases KW - Human KW - Support, Non-U.S. Gov't KW - Support, U.S. Gov't, Non-P.H.S. KW - Health Status Indicators KW - Activities of Daily Living UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85225330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=The+reliability+of+a+self-reported+measure+of+disease%2C+impairment%2C+and+function+in+persons+with+spinal+cord+dysfunction.&rft.au=Hoenig%2C+H%3BMcIntyre%2C+L%3BSloane%2C+R%3BBranch%2C+L+G%3BTruncali%2C+A%3BHorner%2C+R+D&rft.aulast=Hoenig&rft.aufirst=H&rft.date=1998-04-01&rft.volume=79&rft.issue=4&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Modulation of monocyte chemotactic protein-1 production by hyperoxia: importance of RNA stability in control of cytokine production. AN - 79782220; 9533939 AB - Pulmonary oxygen toxicity occurs after prolonged administration of increased fractions of inspired oxygen. Lung damage in this setting manifests as diffuse alveolar damage. In animals exposed to hyperoxia, increased numbers of alveolar macrophages are noted 72 h after initiation of high concentrations of oxygen. Monocyte chemotactic protein-1 (MCP-1) is a cytokine released by a number of cell types that has potent chemotactic activity for monocytes, precursor cells for alveolar macrophages. In the current study, we examined whether MCP-1 production was increased in response to hyperoxia. We used the monocyte/ histiocytic U937 cell line and exposed these cells to hyperoxia for variable amounts of time, then determined MCP-1 concentrations by enzyme-linked immunosorbent assay and MCP-1 mRNA levels by Northern blot analysis. We also examined the effects of dexamethasone on the response of U937 cells to hyperoxia. Finally, as a potential mechanism for regulation of U937 MCP-1 production, we examined effects of hyperoxia on MCP-1 mRNA stability. The results demonstrate that hyperoxia stimulates MCP-1 production after 6 and 24 h of exposure. MCP-1 mRNA levels are also increased after initiation of hyperoxia in part through effects on MCP-1 transcript stability. Dexamethasone significantly reduces MCP-1 production and mRNA levels also in part through effects on transcript stability. These studies suggest monocytes may be attracted to hyperoxia-exposed lungs through enhanced MCP-1 production. MCP-1 production appears to be upregulated in part through post-transcriptional processes in this setting. JF - American journal of respiratory cell and molecular biology AU - Cooper, J A AU - Fuller, J M AU - McMinn, K M AU - Culbreth, R R AD - Pulmonary Sections, Birmingham Veterans Administration Medical Center and the University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. Y1 - 1998/04// PY - 1998 DA - April 1998 SP - 521 EP - 525 VL - 18 IS - 4 SN - 1044-1549, 1044-1549 KW - Chemokine CCL2 KW - 0 KW - Cytokines KW - Glucocorticoids KW - RNA, Messenger KW - Dexamethasone KW - 7S5I7G3JQL KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Gene Expression -- drug effects KW - Drug Stability KW - Tumor Cells, Cultured KW - Gene Expression -- genetics KW - Humans KW - Dexamethasone -- pharmacology KW - RNA, Messenger -- chemistry KW - RNA, Messenger -- physiology KW - Cytokines -- metabolism KW - RNA, Messenger -- genetics KW - Gene Expression -- physiology KW - Glucocorticoids -- pharmacology KW - Chemokine CCL2 -- genetics KW - Oxygen -- pharmacology KW - Chemokine CCL2 -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79782220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Modulation+of+monocyte+chemotactic+protein-1+production+by+hyperoxia%3A+importance+of+RNA+stability+in+control+of+cytokine+production.&rft.au=Cooper%2C+J+A%3BFuller%2C+J+M%3BMcMinn%2C+K+M%3BCulbreth%2C+R+R&rft.aulast=Cooper&rft.aufirst=J&rft.date=1998-04-01&rft.volume=18&rft.issue=4&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-04-30 N1 - Date created - 1998-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabotropic glutamate receptors limit adenylyl cyclase-mediated effects in rat hippocampus via protein kinase C. AN - 79824024; 9572595 AB - Glutamate receptors of the metabotropic type (mGluRs) activate protein kinase C in hippocampus, but few physiological functions of this pathway are known. The present data show that mGluRs utilize protein kinase C to inhibit another second messenger system, the adenylyl cyclase pathway, in neurons of the CA1 area of hippocampus. Activation of mGluRs prevented beta-adrenergic receptors, which couple to adenylyl cyclase, from blocking the slow Ca2+-dependent afterhyperpolarization (AHP). Since the afterhyperpolarization modulates neuronal responsiveness, crosstalk between protein kinase C and the adenylyl cyclase pathway is likely to have physiological consequences. Moreover, mGluRs themselves block the afterhyperpolarization, so the observed interference with the beta-adrenergic response constitutes a hierarchical relationship in which mGluRs are dominant over beta-adrenergic receptors. JF - Neuroscience letters AU - Nouranifar, R AU - Blitzer, R D AU - Wong, T AU - Landau, E AD - Psychiatry Service, Bronx Veterans Administration Medical Center, NY 10468, USA. Y1 - 1998/03/13/ PY - 1998 DA - 1998 Mar 13 SP - 101 EP - 105 VL - 244 IS - 2 SN - 0304-3940, 0304-3940 KW - Receptors, Adrenergic, beta KW - 0 KW - Receptors, Metabotropic Glutamate KW - Cycloleucine KW - 0TQU7668EI KW - 1-amino-1,3-dicarboxycyclopentane KW - 111900-32-4 KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Bucladesine KW - 63X7MBT2LQ KW - Protein Kinase C KW - EC 2.7.11.13 KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Isoproterenol KW - L628TT009W KW - Index Medicus KW - Rats KW - Animals KW - Second Messenger Systems KW - Rats, Sprague-Dawley KW - Receptors, Adrenergic, beta -- physiology KW - Models, Neurological KW - Bucladesine -- pharmacology KW - Male KW - Phorbol 12,13-Dibutyrate -- pharmacology KW - Protein Kinase C -- metabolism KW - Hippocampus -- physiology KW - Cycloleucine -- pharmacology KW - Neurons -- drug effects KW - Neurons -- physiology KW - Cycloleucine -- analogs & derivatives KW - Adenylyl Cyclases -- metabolism KW - Receptors, Metabotropic Glutamate -- physiology KW - Receptors, Metabotropic Glutamate -- agonists KW - Isoproterenol -- pharmacology KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79824024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Metabotropic+glutamate+receptors+limit+adenylyl+cyclase-mediated+effects+in+rat+hippocampus+via+protein+kinase+C.&rft.au=Nouranifar%2C+R%3BBlitzer%2C+R+D%3BWong%2C+T%3BLandau%2C+E&rft.aulast=Nouranifar&rft.aufirst=R&rft.date=1998-03-13&rft.volume=244&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-06-16 N1 - Date created - 1998-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tracheostomy for long-term laryngeal experimentation. AN - 85420143; pmid-9527120 AB - To perform laryngeal research involving long-term survival surgery, a permanent tracheostomy is often necessary. For experiments using a long-term induced canine phonation model, we required a tracheostomy that was placed as low as possible, to maximize the subglottic space superior to the stoma. The ideal experimental tracheostomy would also be safe and easy to perform, require no tracheostomy tube, and be low maintenance, requiring minimal cleaning or suctioning. Tracheostomies were performed in 37 dogs based on previously published methods. If the stoma was placed below the twelfth tracheal ring, the perioperative mortality rate was 57% because of kinking of the trachea and subsequent airway obstruction. When the tracheostomy was performed above this level, the mortality rate was reduced to 3%. A number of significant modifications in technique were made to achieve this improvement and resulted in the last 12 dogs having no complications. Several of the tracheostomies were maintained for more than 18 months. The method derived meets the above criteria for the ideal experimental tracheostomy and also meets our needs for a long-term induced phonation model. JF - Otolaryngology and head and neck surgery AU - Dahm, J D AU - Paniello, R C AD - Department of Otolaryngology-Head and Neck Surgery, Washington University, and the Veterans Administration Medical Center, St. Louis, Missouri, USA. Y1 - 1998/03// PY - 1998 DA - March 1998 SP - 376 EP - 380 VL - 118 IS - 3 Pt 1 SN - 0194-5998, 0194-5998 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Postoperative Complications KW - Intubation, Intratracheal KW - Dogs KW - Time Factors KW - Female KW - Tracheostomy -- methods KW - Models, Biological KW - Phonation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85420143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology+and+head+and+neck+surgery&rft.atitle=Tracheostomy+for+long-term+laryngeal+experimentation.&rft.au=Dahm%2C+J+D%3BPaniello%2C+R+C&rft.aulast=Dahm&rft.aufirst=J&rft.date=1998-03-01&rft.volume=118&rft.issue=3+Pt+1&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Otolaryngology+and+head+and+neck+surgery&rft.issn=01945998&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The interaction of alcoholic liver disease and hepatitis C. AN - 79954386; 9638402 AB - The following article reviews available data of the interaction of alcohol related liver disease and hepatitis C viral infection as well as special considerations for the treatment of these patients. Alcohol worsens the degree and accelerates the progression of hepatic injury, enhances the risk of developing hepatocellular carcinoma and decreases response to interferon therapy. Patients with hepatitis C should avoid alcohol ingestion. JF - Hepato-gastroenterology AU - Marsano, L S AU - Peña, L R AD - Department of Internal Medicine, Lexington Veterans Administration Medical Center, Kentucky, USA. PY - 1998 SP - 331 EP - 339 VL - 45 IS - 20 SN - 0172-6390, 0172-6390 KW - Antiviral Agents KW - 0 KW - Interferons KW - 9008-11-1 KW - Index Medicus KW - Antiviral Agents -- therapeutic use KW - Risk Factors KW - Humans KW - Liver Neoplasms -- epidemiology KW - Interferons -- therapeutic use KW - Carcinoma, Hepatocellular -- epidemiology KW - Hepatitis C -- therapy KW - Liver Diseases, Alcoholic -- therapy KW - Hepatitis C -- complications KW - Hepatitis C -- epidemiology KW - Liver Diseases, Alcoholic -- complications KW - Liver Diseases, Alcoholic -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79954386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepato-gastroenterology&rft.atitle=The+interaction+of+alcoholic+liver+disease+and+hepatitis+C.&rft.au=Marsano%2C+L+S%3BPe%C3%B1a%2C+L+R&rft.aulast=Marsano&rft.aufirst=L&rft.date=1998-03-01&rft.volume=45&rft.issue=20&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Hepato-gastroenterology&rft.issn=01726390&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-09-03 N1 - Date created - 1998-09-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multiple giant cell tumors in a patient with Gulf War syndrome. AN - 79785725; 9542862 AB - "Persian Gulf syndrome" refers to a group of clinical findings found in military personnel who served in the Persian Gulf War. The most commonly reported symptoms include chronic fatigue, headache, and neurologic disorders. Recently, new information has linked Whipple's disease and Ki-1 anaplastic large cell lymphoma to this syndrome. Presented here is an unusual case of multiple giant cell tumors of the hand in a patient with documented Persian Gulf syndrome. The epidemiologic significance between these two entities is unclear, because this is a single reported case. However, the practical message is clear. Physicians must meticulously evaluate patients who are veterans of the Persian Gulf conflict to further our understanding and confirm the existence of this syndrome. JF - Military medicine AU - Cannova, J V AD - Ralph H. Johnson Veterans Administration Medical Center, Department of Surgery, Charleston, SC 29401, USA. Y1 - 1998/03// PY - 1998 DA - March 1998 SP - 184 EP - 185 VL - 163 IS - 3 SN - 0026-4075, 0026-4075 KW - Index Medicus KW - Veterans KW - United States KW - Humans KW - Middle Aged KW - Male KW - Persian Gulf Syndrome -- complications KW - Neoplasms, Multiple Primary -- complications KW - Hand KW - Giant Cell Tumors -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79785725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+medicine&rft.atitle=Multiple+giant+cell+tumors+in+a+patient+with+Gulf+War+syndrome.&rft.au=Cannova%2C+J+V&rft.aulast=Cannova&rft.aufirst=J&rft.date=1998-03-01&rft.volume=163&rft.issue=3&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Military+medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-04-29 N1 - Date created - 1998-04-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The neurotoxicity of amyloid beta protein in aged primates. AN - 79748994; 9546999 AB - Amyloid beta protein deposition is a universal feature of Alzheimer's disease brain. To investigate the effects of amyloid beta protein in aged primates, intracerebral microinjections of solubilized amyloid beta (A beta (1-40)) and control peptides were made into the frontal cortex of 7 primates under stereotactic guidance. Control injections consisted of vehicle alone, a 37 amino acid non toxic peptide (A37), scrambled peptide (CA4), and reverse peptide (A beta (40-1)). Amyloid beta peptide produced dose-dependent cortical lesions that were significantly larger than those produced by vehicle or by isomolar control peptides (3.28 and 2.20 fold larger respectively) (p = < 0.005). In 5 aged primates, the cortex surrounding the amyloid beta lesions contained argyrophilic, thioflavine S fluorescent, Alz 50 and ubiquitin immunoreactive neurons and perikarya. The number of Alz 50 immunoreactive neurons surrounding the amyloid beta injections was significantly greater (mean 127 +/- 39) than the number found surrounding reverse peptide injections (mean 20 +/- 13) and other control peptides (mean 0.8 +/- 0.3) (p < 0.05). Neuronal and neuritic alterations were not found adjacent to the amyloid beta peptide lesions in young monkeys and control injections produced insignificant Alz 50 neuronal positivity. These findings suggest that amyloid beta peptide is neurotoxic in primate brain and that the cytoskeletal response to amyloid beta protein is specific and age-related. JF - Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis AU - McKee, A C AU - Kowall, N W AU - Schumacher, J S AU - Beal, M F AD - Geriatric Research Educational and Clinical Center, Bedford Veterans Administration Medical Center, MA 01730, USA. Y1 - 1998/03// PY - 1998 DA - March 1998 SP - 1 EP - 9 VL - 5 IS - 1 SN - 1350-6129, 1350-6129 KW - Alzheimer's disease antigen KW - 0 KW - Amyloid beta-Peptides KW - Antigens KW - Peptide Fragments KW - Thiazoles KW - Ubiquitins KW - amyloid beta-protein (1-40) KW - thioflavin T KW - 2390-54-7 KW - Index Medicus KW - Animals KW - Age Factors KW - Analysis of Variance KW - Ubiquitins -- analysis KW - Microinjections KW - Antigens -- analysis KW - Haplorhini KW - Neurons -- pathology KW - Microscopy, Fluorescence KW - Ubiquitins -- immunology KW - Thiazoles -- metabolism KW - Brain -- pathology KW - Neurons -- immunology KW - Antigens -- immunology KW - Immunohistochemistry KW - Female KW - Male KW - Peptide Fragments -- toxicity KW - Amyloid beta-Peptides -- toxicity KW - Alzheimer Disease -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79748994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Amyloid+%3A+the+international+journal+of+experimental+and+clinical+investigation+%3A+the+official+journal+of+the+International+Society+of+Amyloidosis&rft.atitle=The+neurotoxicity+of+amyloid+beta+protein+in+aged+primates.&rft.au=McKee%2C+A+C%3BKowall%2C+N+W%3BSchumacher%2C+J+S%3BBeal%2C+M+F&rft.aulast=McKee&rft.aufirst=A&rft.date=1998-03-01&rft.volume=5&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Amyloid+%3A+the+international+journal+of+experimental+and+clinical+investigation+%3A+the+official+journal+of+the+International+Society+of+Amyloidosis&rft.issn=13506129&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-04-16 N1 - Date created - 1998-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Postoperative accelerated radiotherapy in high-risk squamous cell carcinoma of the head and neck: long-term results of a prospective trial. AN - 79699199; 9484942 AB - For patients treated with combination resection and postoperative radiotherapy, the interval between surgery and completion of radiotherapy represents an opportunity for tumor repopulation and treatment failure. A prospective trial to test the feasibility and efficacy of accelerated postoperative radiotherapy was concluded in August of 1990. Thirty-two patients with high-risk pathologic findings were treated with 63 Gy in 35 fractions of 1.8 Gy over 5.2 weeks using a modified concomitant-boost technique. Acute mucosal and skin reactions were increased but tolerable. At a median follow-up of 6 years, the crude in-field recurrence rate for the entire group was 10/32 (31%), with 0/10 (0%) recurrences in patients commencing accelerated radiotherapy within 4 weeks of surgery and 10/22 (45%) recurrences in patients with a delay of more than 4 weeks (p = .006). The rate of late complications appears similar to that seen with conventional radiotherapy, with possibly a higher rate of "consequential"-type late effects. This pilot study suggests that prompt application of accelerated postoperative radiotherapy significantly improves local-regional control and supports the concept of rapid tumor repopulation in the postoperative setting. Various strategies to overcome tumor repopulation are discussed. JF - Head & neck AU - Trotti, A AU - Klotch, D AU - Endicott, J AU - Ridley, M AU - Cantor, A AD - Division of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, James A. Haley Veterans Administration Medical Center at the University of South Florida, Tampa 33612, USA. Y1 - 1998/03// PY - 1998 DA - March 1998 SP - 119 EP - 123 VL - 20 IS - 2 SN - 1043-3074, 1043-3074 KW - Index Medicus KW - Treatment Failure KW - Disease-Free Survival KW - Postoperative Care KW - Neoplasm Staging KW - Dose Fractionation KW - Humans KW - Mouth Mucosa -- radiation effects KW - Pilot Projects KW - Longitudinal Studies KW - Cause of Death KW - Radiotherapy -- adverse effects KW - Neoplasm Recurrence, Local -- prevention & control KW - Feasibility Studies KW - Skin -- radiation effects KW - Radiotherapy, Adjuvant KW - Prospective Studies KW - Logistic Models KW - Risk Factors KW - Radiotherapy Dosage KW - Follow-Up Studies KW - Time Factors KW - Neoplasm Recurrence, Local -- pathology KW - Carcinoma, Squamous Cell -- surgery KW - Carcinoma, Squamous Cell -- secondary KW - Carcinoma, Squamous Cell -- pathology KW - Head and Neck Neoplasms -- radiotherapy KW - Head and Neck Neoplasms -- pathology KW - Head and Neck Neoplasms -- surgery KW - Carcinoma, Squamous Cell -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79699199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Head+%26+neck&rft.atitle=Postoperative+accelerated+radiotherapy+in+high-risk+squamous+cell+carcinoma+of+the+head+and+neck%3A+long-term+results+of+a+prospective+trial.&rft.au=Trotti%2C+A%3BKlotch%2C+D%3BEndicott%2C+J%3BRidley%2C+M%3BCantor%2C+A&rft.aulast=Trotti&rft.aufirst=A&rft.date=1998-03-01&rft.volume=20&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Head+%26+neck&rft.issn=10433074&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-03-27 N1 - Date created - 1998-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Presynaptic nicotinic receptors facilitate monoaminergic transmission. AN - 79691570; 9465015 AB - Nicotine is reported to increase arousal and attention and to elevate mood, effects that are most often associated with changes in the function of monoaminergic neuromodulatory systems (Feldman et al., 1997). Recent studies have shown a nicotinic receptor-mediated presynaptic enhancement of fast glutamatergic (McGehee et al., 1995; Gray et al., 1996) and GABAergic (Lena and Changeux, 1997) transmission. However, the mechanism of nicotinic effects on metabotropic-mediated transmission in general, and on monoaminergic transmission in particular, is less well understood. We have examined nicotinic effects on dorsal raphe neurons of rats using whole-cell current and voltage-clamp recording techniques in vitro. In the majority of these neurons, activation of presynaptic nicotinic receptors induced a depolarization mediated by norepinephrine acting on alpha1 receptors. Blockade of this response revealed a hyperpolarization mediated by serotonin acting on 5-HT1A receptors. Because the norepinephrine effect was sensitive to methyllycaconitine (100 nM), it is concluded that nicotinic receptors with an alpha7 subunit can facilitate release of norepinephrine to activate metabotropic receptors. In contrast, methyllycaconitine-insensitive nicotinic receptors can induce 5-HT release in the dorsal raphe nucleus. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Li, X AU - Rainnie, D G AU - McCarley, R W AU - Greene, R W AD - Harvard Medical School and Brockton Veterans Administration Medical Center, Neuroscience Laboratory, Brockton, Massachusetts 02401, USA. Y1 - 1998/03/01/ PY - 1998 DA - 1998 Mar 01 SP - 1904 EP - 1912 VL - 18 IS - 5 SN - 0270-6474, 0270-6474 KW - Receptors, Adrenergic, alpha-1 KW - 0 KW - Receptors, Nicotinic KW - Receptors, Presynaptic KW - Receptors, Serotonin KW - Receptors, Serotonin, 5-HT1 KW - Serotonin KW - 333DO1RDJY KW - Tetrodotoxin KW - 4368-28-9 KW - Calcium KW - SY7Q814VUP KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Receptors, Serotonin -- drug effects KW - Receptors, Serotonin -- physiology KW - Animals KW - Raphe Nuclei -- physiology KW - Receptors, Adrenergic, alpha-1 -- drug effects KW - Calcium -- pharmacology KW - Raphe Nuclei -- drug effects KW - Receptors, Adrenergic, alpha-1 -- physiology KW - Rats KW - Patch-Clamp Techniques KW - In Vitro Techniques KW - Tetrodotoxin -- pharmacology KW - Brain Stem -- drug effects KW - Norepinephrine -- metabolism KW - Receptors, Presynaptic -- physiology KW - Receptors, Nicotinic -- drug effects KW - Synaptic Transmission -- physiology KW - Receptors, Nicotinic -- physiology KW - Brain Stem -- physiology KW - Serotonin -- metabolism KW - Receptors, Presynaptic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79691570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Presynaptic+nicotinic+receptors+facilitate+monoaminergic+transmission.&rft.au=Li%2C+X%3BRainnie%2C+D+G%3BMcCarley%2C+R+W%3BGreene%2C+R+W&rft.aulast=Li&rft.aufirst=X&rft.date=1998-03-01&rft.volume=18&rft.issue=5&rft.spage=1904&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-03-04 N1 - Date created - 1998-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical and microbiological assessment of Mycobacterium simiae isolates from a single laboratory in Southern Arizona AN - 16550966; 4367604 AB - Mycobacterium simiae was the third most common mycobacterium identified over a 2-year period from a single clinical laboratory in southern Arizona. Thirty-three isolates from 25 patients were identified over 1 year. The isolation of M. simiae was considered clinically significant for only two of 23 evaluable patients. None of five patients with human immunodeficiency virus infection had clinical disease associated with M. simiae. Twenty isolates were available for detailed study. All but one of the 20 isolates were niacin-negative, and 11 were nonphotochromogenic. All 20 isolates had a triple-cluster pattern consistent with M. simiae by high-performance liquid chromatography, and restriction fragment patterns were identical for 16 isolates. Analysis of 16S rDNA confirmed the identity of all the tested isolates as M. simiae. In this study, M. simiae was a frequent clinical isolate but was rarely associated with disease. The organisms isolated were confirmed to be M. simiae but appeared to be phenotypically distinct strains of low virulence. JF - Clinical Infectious Diseases AU - Rynkiewicz, D L AU - Cage, G D AU - Butler, W R AU - Ampel, N M AD - Medical Service (111), Veterans Administration Medical Center, 3601 South Sixth Avenue, Tucson, AZ 85723, USA Y1 - 1998/03// PY - 1998 DA - Mar 1998 SP - 625 EP - 630 VL - 26 IS - 3 SN - 1058-4838, 1058-4838 KW - USA, Arizona KW - clinical isolates KW - man KW - Microbiology Abstracts B: Bacteriology KW - Mycobacterium simiae KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16550966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Clinical+and+microbiological+assessment+of+Mycobacterium+simiae+isolates+from+a+single+laboratory+in+Southern+Arizona&rft.au=Rynkiewicz%2C+D+L%3BCage%2C+G+D%3BButler%2C+W+R%3BAmpel%2C+N+M&rft.aulast=Rynkiewicz&rft.aufirst=D&rft.date=1998-03-01&rft.volume=26&rft.issue=3&rft.spage=625&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium simiae ER - TY - JOUR T1 - Cadmium decreases SGLT1 messenger RNA in mouse kidney cells AN - 16409321; 4325812 AB - Mouse renal cortical tubule cells in primary culture exposed to cadmium (Cd super(2+)) develop decreased Na super(+)-glucose cotransport activity as measured by uptake of the glucose analogue alpha -methylglucoside. RNA was isolated from kidney cell cultures, and after reversed transcription, the DNA was amplified with primers to rat SGLT1 (the high affinity isoform of the sodium glucose cotransporter) and mouse beta -actin. Only one product was identified after amplification with the rat SGLT1 primers, which on sequencing was 96% identical to rat SGLT1. Compared to beta -actin, the intensity of the SGLT1 message declined progressively as CdCl sub(2) concentration in the medium increased from 0 to 10 mu M. Similar decreases in SGLT1 mRNA were also observed as media zinc (Zn super(2+)) concentrations rose from 0 to 75 mu M or as copper (Cu) concentrations increased from 0 to 150 mu M. Exposure to 8 mu M Cd as Cd-metallothionein (Cd sub(7)-MT) also caused a fall in relative SGLT1 mRNA abundance, and at nearly identical internal Cd concentrations of 40-43 pmol/ mu g DNA, both Cd sub(7)-MT and CdCl sub(2) reduced SGLT1 mRNA to 33% of control. In general, the fall in SGLT1 mRNA was more rapid than the decline in Na super(+)-dependent glucose uptake after cells were exposed to Cd super(2+). These findings suggest that the effects of Cd super(2+) and other metals on renal glucose transport are related to decreased expression of SGLT1 message. JF - Toxicology and Applied Pharmacology AU - Blumenthal, S S AU - Ren, L AU - Lewand, D L AU - Krezoski, S K AU - Petering, D H AD - Department of Medicine, Medical College of Wisconsin, Section of Nephrology/111K, Zablocki Veterans Administration Medical Center, 5000 West National Avenue, Milwaukee, WI 53295, USA Y1 - 1998/03// PY - 1998 DA - Mar 1998 SP - 49 EP - 54 VL - 149 IS - 1 SN - 0041-008X, 0041-008X KW - cadmium KW - glucose transporter KW - mRNA KW - mice KW - Toxicology Abstracts KW - X 24165:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16409321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Cadmium+decreases+SGLT1+messenger+RNA+in+mouse+kidney+cells&rft.au=Blumenthal%2C+S+S%3BRen%2C+L%3BLewand%2C+D+L%3BKrezoski%2C+S+K%3BPetering%2C+D+H&rft.aulast=Blumenthal&rft.aufirst=S&rft.date=1998-03-01&rft.volume=149&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Enhanced gamma -glutamyl transpeptidase expression and selective loss of CuZn superoxide dismutase in hepatic iron overload AN - 16394208; 4308377 AB - Liver injury caused by iron overload is presumed to involve lipid peroxidation and the formation of products such as 4-hydroxynonenal (4HNE), which has been implicated in hepatic fibrogenesis. Cellular antioxidants that modulate the formation and detoxification of compounds such as 4HNE may represent important protective mechanisms involved in the response to iron overload. This study examines the relationship between 4HNE, collagen content, and antioxidant defenses in the livers of rats fed carbonyl iron for 10 weeks. Iron-loading resulted in significant increases in iron (8.8-fold), 4HNE (1.7-fold), and hydroxyproline (1.5-fold). Total glutathione content was unchanged by iron, but gamma -glutamyl transpeptidase activity (GGT) increased sixfold and CuZn superoxide dismutase (CuZnSOD) activity decreased >90%. GGT colocalized with iron deposition and was associated with increased GGT mRNA. Decreased CuZnSOD activity was paralleled by a reduction in CuZnSOD protein on Western blot and immunohistochemistry, but no decrease in CuZnSOD mRNA. Glutathione S-transferase (GST) and Mn superoxide dismutase (Mn SOD) activities were also significantly increased by iron loading. These results demonstrate that iron overload significantly alters the expression of antioxidant enzymes associated with glutathione (GGT and GST) and superoxide metabolism (CuZnSOD and MnSOD). Furthermore, the localized induction of GGT may enhance detoxification of lipid peroxidation-derived aldehydes via glutathione-dependent pathways in iron-loaded hepatocytes. These alterations in antioxidant defenses may represent an adaptive response, limiting accumulation 4HNE, and thus, stimulation of collagen synthesis, accounting for the mild fibrogenic response seen in this model of iron overload. JF - Free Radical Biology & Medicine AU - Brown, KE AU - Kinter, M T AU - Oberley, T D AU - Freeman, M L AU - Frierson, H F AU - Ridnour, LA AU - Tao, Y AU - Oberley, L W AU - Spitz AD - Division of Gastroenterology and Hepatology, St. Louis University Health Sciences Center, Box 15250, St. Louis, MO 63110-0250, USA, brown.kyle_e@st-louis.va.gov Y1 - 1998/03/01/ PY - 1998 DA - 1998 Mar 01 SP - 545 EP - 555 VL - 24 IS - 4 SN - 0891-5849, 0891-5849 KW - 4-hydroxynonenal KW - gamma -Glutamyltransferase KW - copper KW - rats KW - zinc KW - Toxicology Abstracts KW - X 24165:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16394208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+Radical+Biology+%26+Medicine&rft.atitle=Enhanced+gamma+-glutamyl+transpeptidase+expression+and+selective+loss+of+CuZn+superoxide+dismutase+in+hepatic+iron+overload&rft.au=Brown%2C+KE%3BKinter%2C+M+T%3BOberley%2C+T+D%3BFreeman%2C+M+L%3BFrierson%2C+H+F%3BRidnour%2C+LA%3BTao%2C+Y%3BOberley%2C+L+W%3BSpitz&rft.aulast=Brown&rft.aufirst=KE&rft.date=1998-03-01&rft.volume=24&rft.issue=4&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Free+Radical+Biology+%26+Medicine&rft.issn=08915849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Formation of zinc protoporphyrin in cultured hepatocytes: Effects of ferrochelatase inhibition, iron chelation or lead AN - 16393444; 4307446 AB - The formation of zinc protoporphyrin in response to lead or iron depletion has previously been investigated in erythroid systems. Because of its possible metabolic role in non-erythroid tissue, we investigated the formation of zinc protoporphyrin in cultured hepatocytes. The effects of lead and inhibitors of ferrochelatase, the iron insertion step of heme synthesis, on the conversion of 5-aminolevulinic acid to zinc protoporphyrin, protoporphyrin and heme were compared in rat and chick embryo hepatocyte cultures. In rat cultures, zinc protoporphyrin was synthesized enzymatically by ferrochelatase, since N-methylmesoporphyrin, an inhibitor of ferrochelatase, caused 40% or greater decreases in both heme and zinc protoporphyrin accumulation and markedly stimulated protoporphyrin accumulation. In addition, chelation of ferrous iron with 2,2'-dipyridyl decreased heme accumulation by 50%, but increased ZPP accumulation by 200%. Zinc protoporphyrin formation in chick embryo hepatocytes required the addition of zinc as well as 5-aminolevulinic acid and apparently was non-enzymatic, since it was not inhibited by N-methylmesoporphyrin nor increased by iron chelation. In the presence of 5-aminolevulinic acid, lead had no effect on zinc protoporphyrin, protoporphyrin or heme accumulation in chick hepatocytes, but decreased all three in rat hepatocytes, with the decrease in protoporphyrin being far greater than that of zinc protoporphyrin or heme. These findings indicate that, in contrast to the effect of lead in erythroid tissue, it did not specifically increase zinc protoporphyrin accumulation or alter iron availability in cultured hepatocytes. JF - Toxicology AU - Jacobs, J M AU - Sinclair, PR AU - Sinclair, J F AU - Gorman, N AU - Walton, H S AU - Wood, S G AU - Nichols, C AD - Veterans Administration Medical Center, Research 151, White River Junction, VT 05009, USA Y1 - 1998/02/06/ PY - 1998 DA - 1998 Feb 06 SP - 95 EP - 105 VL - 125 IS - 2-3 SN - 0300-483X, 0300-483X KW - chelating agents KW - protoporphyrin KW - zinc KW - Toxicology Abstracts KW - X 24165:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16393444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Formation+of+zinc+protoporphyrin+in+cultured+hepatocytes%3A+Effects+of+ferrochelatase+inhibition%2C+iron+chelation+or+lead&rft.au=Jacobs%2C+J+M%3BSinclair%2C+PR%3BSinclair%2C+J+F%3BGorman%2C+N%3BWalton%2C+H+S%3BWood%2C+S+G%3BNichols%2C+C&rft.aulast=Jacobs&rft.aufirst=J&rft.date=1998-02-06&rft.volume=125&rft.issue=2-3&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Ipsilateral neglect: reversal of bias or exaggerated cross-over phenomenon? AN - 85421178; pmid-9534001 AB - When right brain injury produces contralesional neglect (CN), patients typically misbisect lines to the right. However, others demonstrate so-called "ipsilateral neglect" (IN) with misbisection to the left of midpoint. Paradoxically, most patients with CN also demonstrate a 'cross-over' phenomenon whereby they misbisect short lines to the left. It is not known whether patients with IN actually have a contralesional bias opposite the ipsilesional bias observed with CN, or if their performance reflects an exaggerated cross-over. These alternatives can be distinguished by power function analysis which evaluates the relationship between magnitude of perception and stimulus magnitude. Using line bisection tasks to derive a power function, an IN patient showed a reduced exponent (beta = 0.841), falling outside 95% confidence intervals (CI) for controls but within the CI for CN patients. The IN patient showed a greatly increased constant (K = 7.82), extending outside the CI for both controls and CN patients. The results suggest that the anomalous leftward misbisection with IN is associated with an exaggerated cross-over point and not simply reversal of spatial bias. JF - Cortex; a journal devoted to the study of the nervous system and behavior AU - Adair, J C AU - Chatterjee, A AU - Schwartz, R L AU - Heilman, K M AD - Department of Neurology, University of New Mexico Health Sciences Center, USA. Adair.John@Albuquerque.VA.Gov Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 147 EP - 153 VL - 34 IS - 1 SN - 0010-9452, 0010-9452 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Adult KW - Tomography, X-Ray Computed KW - Neuropsychological Tests KW - Male KW - Cerebral Infarction -- radiography KW - Cognition Disorders -- psychology KW - Functional Laterality -- physiology KW - Cerebral Infarction -- psychology KW - Cognition Disorders -- radiography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85421178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.atitle=Ipsilateral+neglect%3A+reversal+of+bias+or+exaggerated+cross-over+phenomenon%3F&rft.au=Adair%2C+J+C%3BChatterjee%2C+A%3BSchwartz%2C+R+L%3BHeilman%2C+K+M&rft.aulast=Adair&rft.aufirst=J&rft.date=1998-02-01&rft.volume=34&rft.issue=1&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.issn=00109452&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Variability and correlated noise in the discharge of neurons in motor and parietal areas of the primate cortex. AN - 85219186; pmid-9437036 AB - We analyzed the magnitude and interneuronal correlation of the variability in the activity of single neurons that were recorded simultaneously using a multielectrode array in the primary motor cortex and parietal areas 2/5 in rhesus monkeys. The animals were trained to move their arms in one of eight directions as instructed by a visual target. The relationship between variability (SD) and mean of the discharge rate was described by a power function with a similar exponent ( approximately 0.57), regardless of the cortical area or the behavioral condition. We examined whether the deviation from mean activity between target onset and the end of the movement was correlated on a trial-by-trial basis with variability in activity during the hold period before target onset. In both cortical areas, for about a quarter of the neurons, the neuronal noise of these two periods was positively correlated, whereas significant negative correlations were seldom observed. Overall, neurons with higher signal correlation (i.e., similar directional pattern) showed higher noise correlation in both cortical areas. On the other hand, when the data were divided according to the distance between the electrode tips from which the neurons were recorded, a consistent relationship between the signal and noise correlations was found only for pairs of neurons recorded through the same electrode. These results suggest that nearby neurons with similar directional tuning carry primarily redundant messages, whereas neurons in separate cortical columns perform more independent processing. JF - The Journal of Neuroscience AU - Lee, D AU - Port, N L AU - Kruse, W AU - Georgopoulos, A P AD - Brain Sciences Center, Veterans Administration Medical Center, Minneapolis, Minnesota 55417, USA. PY - 1998 SP - 1161 EP - 1170 VL - 18 IS - 3 SN - 0270-6474, 0270-6474 KW - Motor Cortex KW - Artifacts KW - Support, U.S. Gov't, P.H.S. KW - Neurons KW - Neural Pathways KW - Animal KW - Action Potentials KW - Support, Non-U.S. Gov't KW - Macaca mulatta KW - Electrophysiology KW - Parietal Lobe KW - Primates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85219186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Neuroscience&rft.atitle=Variability+and+correlated+noise+in+the+discharge+of+neurons+in+motor+and+parietal+areas+of+the+primate+cortex.&rft.au=Lee%2C+D%3BPort%2C+N+L%3BKruse%2C+W%3BGeorgopoulos%2C+A+P&rft.aulast=Lee&rft.aufirst=D&rft.date=1998-02-01&rft.volume=18&rft.issue=3&rft.spage=1161&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Role of IGF-I in normal mammary development. AN - 79740485; 9516076 AB - Growth hormone (GH) is now believed to be the pituitary factor that is responsible for mammary ductal morphogenesis. Mammary development at puberty occurs because of synergy between GH and estrogen on formation of terminal end buds (TEBs). TEBs extend into the substance of the mammary gland fat pad, resulting in ductal morphogenesis. Ultimately, the whole mammary fat pad accommodates a complex network of ducts. IGF-I or des(1-3) IGF-I mimic the actions of GH on TEB formation in hypophysectomized, gonadectomized rats. Since GH stimulates IGF-I mRNA within the mammary gland synergistically, we hypothesize that IGF-I partially mediates actions of GH in mammary gland development. Studies in transgenic mice overexpressing IGF-I, des(1-3) IGF-I, or IGFBP-3 show that IGF-I causes ductal hypertrophy in the lactating mouse and prevention of post-lactational mammary gland involution. One of the mechanisms for this effect involves apoptosis. The potential role of GH or IGF-I in mammary carcinogenesis, and the applicability of animal studies to humans, are discussed. JF - Breast cancer research and treatment AU - Kleinberg, D L AD - Veterans Administration and New York University Medical Centers, New York, NY 10010, USA. Kleind02@popmail.med.nyu.edu Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 201 EP - 208 VL - 47 IS - 3 SN - 0167-6806, 0167-6806 KW - Insulin-Like Growth Factor II KW - 67763-97-7 KW - Index Medicus KW - Rats KW - Animals KW - Mice KW - Female KW - Insulin-Like Growth Factor II -- physiology KW - Mammary Glands, Animal -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79740485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+cancer+research+and+treatment&rft.atitle=Role+of+IGF-I+in+normal+mammary+development.&rft.au=Kleinberg%2C+D+L&rft.aulast=Kleinberg&rft.aufirst=D&rft.date=1998-02-01&rft.volume=47&rft.issue=3&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Breast+cancer+research+and+treatment&rft.issn=01676806&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-05-04 N1 - Date created - 1998-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Active and passive roles of astrocytes in neurologic disease: commentary on forum position paper. AN - 79727117; 9498216 JF - Neurotoxicology AU - Norenberg, M D AD - Laboratory of Neuropathology, Veterans Administration Medical Center, Miami, FL 33101, USA. Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 23 EP - 6; discussion 37-8 VL - 19 IS - 1 SN - 0161-813X, 0161-813X KW - Index Medicus KW - Animals KW - Humans KW - Nervous System Diseases -- etiology KW - Astrocytes -- physiology KW - Nervous System Diseases -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79727117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Active+and+passive+roles+of+astrocytes+in+neurologic+disease%3A+commentary+on+forum+position+paper.&rft.au=Norenberg%2C+M+D&rft.aulast=Norenberg&rft.aufirst=M&rft.date=1998-02-01&rft.volume=19&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-04-21 N1 - Date created - 1998-04-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Neurotoxicology. 1998 Feb;19(1):7-17; discussion 37-8 [9498214] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. Myeloma Aredia Study Group. AN - 79682429; 9469347 AB - To determine the efficacy and safety of 21 monthly cycles of pamidronate therapy in patients with advanced multiple myeloma. Patients with stage III myeloma and at least one lytic lesion received either placebo or pamidronate 90 mg intravenously administered as a 4-hour infusion monthly for 21 cycles. At study entry, the patients were stratified according to whether they were to receive first-line (stratum 1) or second-line (stratum 2) antimyeloma chemotherapy. Skeletal events (pathologic fracture, radiation or surgery to bone, and spinal cord compression) and hypercalcemia were assessed monthly. The results of the first nine previously reported cycles are extended to 21 cycles. Of the 392 randomized patients, efficacy could be evaluated in 198 who received pamidronate and 179 who received placebo. After 21 cycles, the proportion of patients who developed any skeletal event was lower in the pamidronate-group (P = .015). The mean number of skeletal events per year was less in the pamidronate-group (1.3) than in placebo-treated patients (2.2; P = .008). Although survival was not different between the pamidronate-treated group and placebo patients overall, stratum 2 patients who received pamidronate lived longer than those who received placebo (14 v 21 months, P = .041). Pamidronate was safe and well tolerated during the 21 cycles of therapy. Long-term monthly infusions of pamidronate as an adjunct to chemotherapy are superior to chemotherapy alone in reducing skeletal events in stage III multiple myeloma patients, and may improve the survival of patients on salvage therapy. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Berenson, J R AU - Lichtenstein, A AU - Porter, L AU - Dimopoulos, M A AU - Bordoni, R AU - George, S AU - Lipton, A AU - Keller, A AU - Ballester, O AU - Kovacs, M AU - Blacklock, H AU - Bell, R AU - Simeone, J F AU - Reitsma, D J AU - Heffernan, M AU - Seaman, J AU - Knight, R D AD - West Los Angeles Veterans Affairs Medical Center and the Jonsson Comprehensive Cancer Center, University of California, 90073, USA. berenson.james@west-la.va.gov Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 593 EP - 602 VL - 16 IS - 2 SN - 0732-183X, 0732-183X KW - Diphosphonates KW - 0 KW - pamidronate KW - OYY3447OMC KW - Index Medicus KW - Drug Administration Schedule KW - Double-Blind Method KW - Infusions, Intravenous KW - Humans KW - Spinal Fractures -- etiology KW - Fractures, Spontaneous -- prevention & control KW - Fractures, Spontaneous -- etiology KW - Spinal Fractures -- prevention & control KW - Survival Rate KW - Middle Aged KW - Female KW - Male KW - Survival Analysis KW - Diphosphonates -- adverse effects KW - Multiple Myeloma -- drug therapy KW - Diphosphonates -- administration & dosage KW - Osteolysis -- etiology KW - Multiple Myeloma -- complications KW - Osteolysis -- prevention & control KW - Multiple Myeloma -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79682429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Long-term+pamidronate+treatment+of+advanced+multiple+myeloma+patients+reduces+skeletal+events.+Myeloma+Aredia+Study+Group.&rft.au=Berenson%2C+J+R%3BLichtenstein%2C+A%3BPorter%2C+L%3BDimopoulos%2C+M+A%3BBordoni%2C+R%3BGeorge%2C+S%3BLipton%2C+A%3BKeller%2C+A%3BBallester%2C+O%3BKovacs%2C+M%3BBlacklock%2C+H%3BBell%2C+R%3BSimeone%2C+J+F%3BReitsma%2C+D+J%3BHeffernan%2C+M%3BSeaman%2C+J%3BKnight%2C+R+D&rft.aulast=Berenson&rft.aufirst=J&rft.date=1998-02-01&rft.volume=16&rft.issue=2&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-03-02 N1 - Date created - 1998-03-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Oncol. 1998 Jul;16(7):2572-3 [9667282] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Psychotherapeutic agents in older adults. Commonly prescribed and over-the-counter remedies: causes of confusion. AN - 79680778; 9456338 AB - Acute confusion is associated with significant morbidity and mortality among older persons. Among the common causes of confusion, medications are at the top of the list. Since virtually any drug can cause confusion, it is helpful for the clinician to know which patients are at risk and which medications are risky. At particular risk are patients with dementia and patients whose pharmacokinetics or pharmacodynamics have been impaired by the aging process or diseases. The list of medications that can cause confusion is a long one, yet it can be remembered by the mnemonic ACUTE CHANGE IN MS (mental status). In addition to recognizing the offending agent, it is prudent for clinicians to prevent the chance of drug-induced confusion. One of the safest ways to do this is to avoid too many medications since the risk of adverse drug events rises exponentially with the number of medications prescribed. JF - Clinics in geriatric medicine AU - Flaherty, J H AD - Geriatric Research Education and Clinical Center, St. Louis Veterans Administration, Louis, Missouri 63104, USA. Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 101 EP - 127 VL - 14 IS - 1 SN - 0749-0690, 0749-0690 KW - Nonprescription Drugs KW - 0 KW - Index Medicus KW - Drug Interactions KW - Age Factors KW - Delirium -- chemically induced KW - Humans KW - Polypharmacy KW - Aged KW - Nonprescription Drugs -- adverse effects KW - Confusion -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79680778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+geriatric+medicine&rft.atitle=Psychotherapeutic+agents+in+older+adults.+Commonly+prescribed+and+over-the-counter+remedies%3A+causes+of+confusion.&rft.au=Flaherty%2C+J+H&rft.aulast=Flaherty&rft.aufirst=J&rft.date=1998-02-01&rft.volume=14&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Clinics+in+geriatric+medicine&rft.issn=07490690&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-03-19 N1 - Date created - 1998-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Resilience-Recovery Factors in Post-Traumatic Stress Disorder among Female and Male Vietnam Veterans: Hardiness, Postwar Social Support, and Additional Stressful Life Events AN - 61511561; 9905834 AB - Structural equation modeling procedures were used to examine relationships among several war zone stressor dimensions, resilience- recovery factors, & post-traumatic stress disorder symptoms in a national sample of 1,632 Vietnam veterans (26% women & 74% men). A 9-factor measurement model was specified on a mixed-gender subsample of the data & then replicated on separate subsamples of female & male veterans. For both genders, the structural models supported strong mediation effects for the intrapersonal resource characteristic of hardiness, postwar structural & functional social support, & additional negative life events in the postwar period. Support for moderator effects or buffering in terms of interactions between war zone stressor level & resilience-recovery factors was minimal. 4 Tables, 3 Figures, 105 References. [Reprinted with permission from the American Psychological Association] JF - Journal of Personality and Social Psychology AU - King, Lynda A AU - King, Daniel W AU - Fairbank, John A AU - Keane, Terence M AU - Adams, Gary A AD - National Center Post-Traumatic Stress Disorder Women's Health Sciences Division Boston Dept Veterans Affairs Medical Center, 150 South Huntington Ave MA 02130 king.lynda@boston.va.gov Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 420 EP - 434 VL - 74 IS - 2 SN - 0022-3514, 0022-3514 KW - Veterans KW - Rehabilitation KW - Vietnam War KW - Males KW - Stress KW - United States of America KW - Social Support KW - Females KW - Posttraumatic Stress Disorder KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61511561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Personality+and+Social+Psychology&rft.atitle=Resilience-Recovery+Factors+in+Post-Traumatic+Stress+Disorder+among+Female+and+Male+Vietnam+Veterans%3A+Hardiness%2C+Postwar+Social+Support%2C+and+Additional+Stressful+Life+Events&rft.au=King%2C+Lynda+A%3BKing%2C+Daniel+W%3BFairbank%2C+John+A%3BKeane%2C+Terence+M%3BAdams%2C+Gary+A&rft.aulast=King&rft.aufirst=Lynda&rft.date=1998-02-01&rft.volume=74&rft.issue=2&rft.spage=420&rft.isbn=&rft.btitle=&rft.title=Journal+of+Personality+and+Social+Psychology&rft.issn=00223514&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JPSPB2 N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Vietnam War; Veterans; Females; Males; Rehabilitation; United States of America; Social Support; Stress ER - TY - RPRT T1 - Final record of decision for the Defense Reutilization and Marketing Office Yard (AOC 32) and Petroleum, Oil, and Lubricants Storage Area (AOC 43A) Fort Devens, Massachusetts AN - 52416669; 2000-000543 AB - This decision document presents the U.S. Army's selected remedial actions for AOCs 32 DRMO Yard, including Underground Storage Tank (UST Number 13), and 43A (the POL Storage Area) at Devens, MA. It was developed in accordance with the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of 1980 as amended, 42 United States Code (U.S.C.) 9601 et seq., and the National Oil and Hazardous Substances Pollution Contingency Plan (NCP) as amended, 40 Code of Federal Regulations (CFR) Part 300, to the extent practicable. The Devens Base Realignment and Closure (BRAC) Environmental Coordinator; the Installation Commander; and the Director of the Waste Management Division, U.S. Environmental Protection Agency (USEPA) New England have been delegated the authority to approve this Record of Decision (ROD). This ROD is based on the Administrative Record that has been developed in accordance with Section 113(k) of CERCLA. The Administrative Record is available for public review at the Devens BRAC Environmental Office, Building P-l2, Devens, MA, and the Ayer Town Hall, Main Street, Ayer, MA. The Administrative Record Index (appendix A of this ROD) identifies each of the items considered during the selection of the remedial actions. JF - Final record of decision for the Defense Reutilization and Marketing Office Yard (AOC 32) and Petroleum, Oil, and Lubricants Storage Area (AOC 43A) Fort Devens, Massachusetts Y1 - 1998/02// PY - 1998 DA - February 1998 SP - 193 KW - United States KW - hazardous waste KW - medical geology KW - regulations KW - reclamation KW - government agencies KW - environmental analysis KW - remediation KW - ground water KW - waste management KW - controls KW - Massachusetts KW - decontamination KW - Fort Devens Massachusetts KW - soils KW - leaking underground storage tanks KW - monitoring KW - underground storage KW - markets KW - pollutants KW - U. S. Environmental Protection Agency KW - pollution KW - decision-making KW - petroleum products KW - organic compounds KW - underground installations KW - hydrocarbons KW - military facilities KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52416669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1998-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Final+record+of+decision+for+the+Defense+Reutilization+and+Marketing+Office+Yard+%28AOC+32%29+and+Petroleum%2C+Oil%2C+and+Lubricants+Storage+Area+%28AOC+43A%29+Fort+Devens%2C+Massachusetts&rft.title=Final+record+of+decision+for+the+Defense+Reutilization+and+Marketing+Office+Yard+%28AOC+32%29+and+Petroleum%2C+Oil%2C+and+Lubricants+Storage+Area+%28AOC+43A%29+Fort+Devens%2C+Massachusetts&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from NTIS database, National Technical Information Service, Springfield, VA, United States N1 - Date revised - 2000-01-01 N1 - Availability - National Technical Information Service, (703)605-6000, order number ADA349259NEG, Springfield, VA, United States N1 - SuppNotes - Final report; Contract DAAA15-94-D-0012 N1 - Last updated - 2012-06-07 ER - TY - RPRT T1 - Stereotactic Pallidotomy for Treatment of Parkinson's Disease. Technology Assessment Program. Report 8 AN - 20187320; 4465950 AB - The Veterans Health Administration, Office of Research and Development, Management Decision and Research Center, Technology Assessment Program assessed the effectiveness and appropriateness of stereotactic pallidotomy for the treatment of Parkinson's disease by systematically reviewing the published research. AU - Kottler, A AU - Hayes, D AU - Adams, E J AU - Alligood, E C AU - Flynn, K L Y1 - 1998/02// PY - 1998 DA - Feb 1998 SP - 38 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; CSA Neurosciences Abstracts KW - Neurodegenerative diseases KW - Movement disorders KW - Parkinson's disease KW - pallidotomy KW - A 01490:Miscellaneous KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20187320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Industrial+and+Applied+Microbiology+Abstracts+%28Microbiology+A%29&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Kottler%2C+A%3BHayes%2C+D%3BAdams%2C+E+J%3BAlligood%2C+E+C%3BFlynn%2C+K+L&rft.aulast=Kottler&rft.aufirst=A&rft.date=1998-02-01&rft.volume=&rft.issue=&rft.spage=38&rft.isbn=&rft.btitle=Stereotactic+Pallidotomy+for+Treatment+of+Parkinson%27s+Disease.+Technology+Assessment+Program.+Report+8&rft.title=Stereotactic+Pallidotomy+for+Treatment+of+Parkinson%27s+Disease.+Technology+Assessment+Program.+Report+8&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - SuppNotes - Report: MTA-98-012. Available from: NTIS, 5285 Port Royal Rd, Springfield, VA 22161, USA. 1-800- 553-NTIS or 1-703-605-6000 or orders[at]ntis.fedworld.gov. NTIS accession number: PB99106452. N1 - Last updated - 2015-03-27 ER - TY - JOUR T1 - Oxidized heme proteins in an animal model of hemochromatosis. AN - 79657026; 9433898 AB - Hemichrome formation resulting from oxidation of heme proteins has been proposed as sensitive indicator of iron-induced oxidative stress. The Heme Protein Spectra Analysis Program was used to quantitate oxidized heme proteins (OHP) in chronic hepatic iron overload in vivo. Rats were fed a diet containing carbonyl iron for 14 months with or without vitamin E supplementation. A 30-fold increase in hepatic iron concentration was observed in rats fed the iron-containing diet. At baseline, total OHP and TBARS were significantly elevated in iron-loaded livers but no increase in hemichrome was seen. During 3 h of spontaneous oxidation, hemichrome formation increased significantly in iron-loaded livers compared to controls. Although supplemental vitamin E was associated with lower levels of OHP and TBARS in iron-loaded livers at baseline, it did not significantly inhibit hemichrome formation during in vitro oxidation. In conclusion, an increase in hemichrome formation in iron-loaded livers was observed only during oxidation in vitro. These results suggest that total OHP is more sensitive than hemichrome formation as an indicator of oxidative stress in this in vivo model of iron overload. JF - Free radical biology & medicine AU - Brown, K E AU - Knudsen, C A AD - John Cochran Veterans Administration Medical Center, Department of Internal Medicine, St. Louis University School of Medicine, MO, USA. Y1 - 1998/01/15/ PY - 1998 DA - 1998 Jan 15 SP - 239 EP - 244 VL - 24 IS - 2 SN - 0891-5849, 0891-5849 KW - Hemeproteins KW - 0 KW - Thiobarbituric Acid Reactive Substances KW - hemichrome KW - Vitamin E KW - 1406-18-4 KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Animals KW - Vitamin E -- metabolism KW - Liver -- metabolism KW - Vitamin E -- blood KW - Iron -- metabolism KW - Oxidation-Reduction KW - Rats KW - Thiobarbituric Acid Reactive Substances -- metabolism KW - Rats, Sprague-Dawley KW - Iron -- administration & dosage KW - Kinetics KW - Diet KW - Vitamin E -- administration & dosage KW - Male KW - Hemeproteins -- metabolism KW - Hemochromatosis -- chemically induced KW - Hemochromatosis -- metabolism KW - Disease Models, Animal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79657026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Oxidized+heme+proteins+in+an+animal+model+of+hemochromatosis.&rft.au=Brown%2C+K+E%3BKnudsen%2C+C+A&rft.aulast=Brown&rft.aufirst=K&rft.date=1998-01-15&rft.volume=24&rft.issue=2&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-02-19 N1 - Date created - 1998-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - "Speech problem" subsequent to carbon monoxide exposure? I the jury. AN - 85417870; pmid-9519393 AB - Exposure to carbon monoxide can damage the nervous system. Sometimes that damage disrupts speech, and sometimes it does not. And, when it does, not all of what one hears may have an organic basis. Coming to grips with altered speech can alter people in different ways--consciously and unconsciously. Finding out what is real and what is not is a good reason for getting up in the morning. It's my job. I'm a speech pathologist. JF - Seminars in speech and language AU - Wertz, R T AD - Veterans Administration Medical Center, Nashville, TN 37212, USA. Y1 - 1998 PY - 1998 DA - 1998 SP - 59 EP - 69 VL - 19 IS - 1 SN - 0734-0478, 0734-0478 KW - Index Medicus KW - National Library of Medicine KW - Apraxias -- therapy KW - Humans KW - Speech Therapy KW - Female KW - Apraxias -- diagnosis KW - Aphasia -- etiology KW - Aphasia -- diagnosis KW - Carbon Monoxide Poisoning -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85417870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+speech+and+language&rft.atitle=%22Speech+problem%22+subsequent+to+carbon+monoxide+exposure%3F+I+the+jury.&rft.au=Wertz%2C+R+T&rft.aulast=Wertz&rft.aufirst=R&rft.date=1998-01-01&rft.volume=19&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Seminars+in+speech+and+language&rft.issn=07340478&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Receptor-targeted delivery of an intracellular toxin to outer hair cells by fibroblast growth factor. AN - 85417230; pmid-9472743 AB - The presence and distribution of functional, high-affinity receptors for fibroblast growth factors (FGFs) in the neonatal organ of Corti were probed using the intracellular toxin saporin conjugated to basic FGF (FGF-2). FGFs that bind to high-affinity FGF receptors are internalized as part of the normal process of receptor inactivation. The receptor can thus be used for the targeted delivery of molecules conjugated to FGF into the cytoplasm. Incubation of postnatal day 5 (P5) rat organ of Corti cultures with FGF-saporin caused a dose dependent destruction of outer hair cells, Deiters cells and outer pillar cells. Inner hair cells and other cells were unaffected. Organ of Corti cultures at P0 and P10 showed much less damage than at P5. The results suggest that outer hair cells and adjacent supporting cells in the organ of Corti transiently express high-affinity FGF receptors, and that these receptors can mediate the intracellular delivery of bioactive molecules. JF - Hearing research AU - Dazert, S AU - Baird, A AU - Ryan, A F AD - Department of Surgery/Otolaryngology, UCSD School of Medicine and Veterans Administration Medical Center, La Jolla, CA 92093-0666, USA. Y1 - 1998/01// PY - 1998 DA - Jan 1998 SP - 143 EP - 148 VL - 115 IS - 1-2 SN - 0378-5955, 0378-5955 KW - National Library of Medicine KW - Animals KW - Animals, Newborn KW - Cytoplasm: drug effects KW - Cytoplasm: metabolism KW - Drug Carriers KW - Fibroblast Growth Factor 2: chemistry KW - *Fibroblast Growth Factor 2: toxicity KW - *Hair Cells, Auditory, Outer: drug effects KW - Hair Cells, Auditory, Outer: metabolism KW - Hair Cells, Auditory, Outer: pathology KW - *Immunotoxins: toxicity KW - *N-Glycosyl Hydrolases KW - Organ Culture Techniques KW - Organ of Corti: growth & development KW - *Organ of Corti: metabolism KW - Plant Proteins: chemistry KW - *Plant Proteins: toxicity KW - Rats KW - Rats, Sprague-Dawley KW - *Receptor Protein-Tyrosine Kinases: drug effects KW - Receptor, Fibroblast Growth Factor, Type 2 KW - *Receptors, Fibroblast Growth Factor: drug effects KW - Ribosome Inactivating Proteins, Type 1 KW - Vestibular Nucleus, Lateral: drug effects KW - Vestibular Nucleus, Lateral: pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85417230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hearing+research&rft.atitle=Receptor-targeted+delivery+of+an+intracellular+toxin+to+outer+hair+cells+by+fibroblast+growth+factor.&rft.au=Dazert%2C+S%3BBaird%2C+A%3BRyan%2C+A+F&rft.aulast=Dazert&rft.aufirst=S&rft.date=1998-01-01&rft.volume=115&rft.issue=1-2&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Hearing+research&rft.issn=03785955&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2012-06-11 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The role of epidermal growth factor (EGF) and its receptor in mucosal protection, adaptation to injury, and ulcer healing: involvement of EGF-R signal transduction pathways. AN - 85414650; pmid-9872493 AB - Growth factors and their receptors are known to play important roles in normal cell proliferation, morphogenesis, tissue repair, and ulcer healing. Epidermal growth factor (EGF) inhibits acid secretion, exerts a trophic effect on gastroduodenal mucosa, protects gastric mucosa against injury, mediates mucosal adaptation, and accelerates gastroduodenal ulcer healing by stimulating cell migration and proliferation. EGF exerts its actions by binding to its receptor, EGF-R, a transmembrane protein tyrosine kinase, which triggers receptor dimerization, autophosphorylation, and recruitment of kinase substrates. These events result in Ras (GTP-binding protein) activation of the Ras/Raf/MAP kinase pathway, leading to phosphorylation of regulatory proteins and transcription factors and culminating in cell proliferation. Other pathways potentially activated by EGF include the phosphatidylinositol pathway and the JAK/STAT signaling pathway. Recent studies demonstrated that EGF-R-associated tyrosine kinase plays an essential role in regulating gastric mucosal cell proliferation after acute injury and further demonstrated activation of the EGF-R gene, EGF-R phosphorylation, and increased MAP kinase activity during early stages of experimental gastric ulcer healing. Finally, experimental data indicate that Helicobacter pylori vacuolating cytotoxin inhibits healing of experimental gastric ulcers, cell proliferation, binding of EGF to its receptor, EGF-induced EGF-R phosphorylation, and MAP kinase (ERK-2) activation. These H. pylori actions can explain its interference with the ulcer healing process. JF - Journal of clinical gastroenterology AU - Tarnawski, A S AU - Jones, M K AD - Veterans Administration Medical Center, Long Beach, California 90822, USA. Y1 - 1998 PY - 1998 DA - 1998 SP - S12 EP - S20 VL - 27 Suppl 1 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Wound Healing KW - Helicobacter pylori -- physiology KW - Helicobacter Infections -- physiopathology KW - Stomach Ulcer -- physiopathology KW - Gastric Mucosa -- physiopathology KW - Receptor, Epidermal Growth Factor -- physiology KW - Gastric Mucosa -- injuries KW - Signal Transduction KW - Epidermal Growth Factor -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85414650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=The+role+of+epidermal+growth+factor+%28EGF%29+and+its+receptor+in+mucosal+protection%2C+adaptation+to+injury%2C+and+ulcer+healing%3A+involvement+of+EGF-R+signal+transduction+pathways.&rft.au=Tarnawski%2C+A+S%3BJones%2C+M+K&rft.aulast=Tarnawski&rft.aufirst=A&rft.date=1998-01-01&rft.volume=27+Suppl+1&rft.issue=&rft.spage=S12&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-01-14 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Affective Prosodic Disturbance Subsequent to Right Hemisphere Stroke: A Clinical Application AN - 85333990; llba-9810597 AB - The hypothesis of E. D. Ross (1981) regarding the disruption of affective prosody subsequent to right hemisphere brain damage is examined. Patients who had suffered a right hemisphere stroke (N = 20) were compared with normal, non-brain-damaged subjects ([Ss] N = 18) for affective prosody in spontaneous speech, gesturing accompanying spontaneous speech, repetition of affective prosody, comprehension of affective prosody, & comprehension of affective gestures. In addition, right-hemisphere-damage Ss were classified with Ross' prosodic taxonomy. All right-hemisphere-damage Ss displayed affective prosodic disturbance in spontaneous speech. Only one normal S was judged mildly dysprosodic. The right-hemisphere-damage group had significantly more difficulty in repeating affective prosody & comprehending affective gestures. There were no significant group differences in gestures accompanying spontaneous speech or comprehending affective prosody. Classification on Ross' taxonomy was not systematically relatable to site of lesion. Dysprosody without coexisting dysarthria was present in three right-hemisphere-damage Ss, but 17 displayed a coexisting dysarthria. It is concluded that affective dysprosody is common after right hemisphere damage but that relationship between classification of dysprosody & site of lesion or the contribution of coexisting dysarthria to dysprosody is not clear. 7 Tables, 30 References. Adapted from the source document JF - Journal of Neurolinguistics AU - Wertz, Robert T AU - Henschel, Constance R AU - Auther, Linda L AU - Ashford, John R AU - Kirshner, Howard S AD - Veterans Administration Medical Center, 1310 24th Ave South Nashville TN 37212 Y1 - 1998/01// PY - 1998 DA - Jan 1998 SP - 89 EP - 102 VL - 11 IS - 1-2 SN - 0911-6044, 0911-6044 KW - *Suprasegmentals (85750) KW - *Emotions (21600) KW - *Cerebral Dominance (11500) KW - *Brain Damage (09400) KW - *Gestures (27950) KW - article KW - 4411: semantics; pragmatics KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85333990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurolinguistics&rft.atitle=Affective+Prosodic+Disturbance+Subsequent+to+Right+Hemisphere+Stroke%3A+A+Clinical+Application&rft.au=Wertz%2C+Robert+T%3BHenschel%2C+Constance+R%3BAuther%2C+Linda+L%3BAshford%2C+John+R%3BKirshner%2C+Howard+S&rft.aulast=Wertz&rft.aufirst=Robert&rft.date=1998-01-01&rft.volume=11&rft.issue=1-2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurolinguistics&rft.issn=09116044&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2003-10-01 N1 - Last updated - 2014-06-17 N1 - CODEN - JONEE8 N1 - SubjectsTermNotLitGenreText - *Suprasegmentals (85750); *Brain Damage (09400); *Cerebral Dominance (11500); *Emotions (21600); *Gestures (27950) ER - TY - JOUR T1 - Nurses, indirect trauma, and prevention. AN - 79807560; 9549948 AB - To begin examining the nature of vicarious or indirect trauma and to discuss risk factors and prevention strategies. Despite the fact that many nurses are traumatized indirectly, few recognize the insidious development of such trauma. The dynamics of indirect trauma are relevant to nursing as are risk factors and prevention strategies. Brief review of the literature (1974-1997) on vicarious trauma, compassion fatigue, secondary traumatic stress disorder, and traumatic countertransference using short vignettes for illustration. Nurses who are informed about vicarious trauma and who actively maintain a balanced personal and professional life are in the best position to bring themselves and their clients through the many hazards of trauma work. The implications of vicarious or indirect trauma for nurses and clients are serious and complex requiring thoughtful analysis and research to clarify its effects. JF - Image--the journal of nursing scholarship AU - Clark, M L AU - Gioro, S AD - Veterans Administration Medical and Regional Office Center, Togus, Maine 04330, USA. Y1 - 1998 PY - 1998 DA - 1998 SP - 85 EP - 87 VL - 30 IS - 1 SN - 0743-5150, 0743-5150 KW - Index Medicus KW - Nursing KW - Risk Factors KW - Humans KW - Countertransference (Psychology) KW - Anxiety Disorders -- prevention & control KW - Anxiety Disorders -- psychology KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- psychology KW - Stress Disorders, Post-Traumatic -- nursing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79807560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Image--the+journal+of+nursing+scholarship&rft.atitle=Nurses%2C+indirect+trauma%2C+and+prevention.&rft.au=Clark%2C+M+L%3BGioro%2C+S&rft.aulast=Clark&rft.aufirst=M&rft.date=1998-01-01&rft.volume=30&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Image--the+journal+of+nursing+scholarship&rft.issn=07435150&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-05-08 N1 - Date created - 1998-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of clozapine therapy in schizophrenic individuals at risk for tardive dyskinesia. AN - 79782454; 9541336 AB - Neuroleptics were the first modern class of pharmacotherapeutic agents available for the treatment of schizophrenia. Although they were effective in reducing florid psychotic symptoms, up to 90% of treated individuals subsequently developed extrapyramidal symptoms (EPS) (akathisia, dystonia, or parkinsonism), and about 20% developed tardive dyskinesia (TD). When clozapine became commercially available for treatment-resistant and treatment-intolerant (i.e., prone to EPS and TD) schizophrenic individuals, it became apparent that an antipsychotic need not induce motor side effects to be efficacious in reducing the symptomatology of schizophrenia. Sociodemographic, behavioral, and clinical predictors of TD are useful in identifying a subset of schizophrenic individuals who would benefit from treatment with clozapine, the prototype atypical antipsychotic whose efficacy and motor side effect profile are superior to those of chlorpromazine. This favorable motor side effect profile of clozapine contributes to improved patient outcomes by reducing noncompliance, substance abuse, and suicide, resulting in improved quality of life and savings on health care costs. JF - The Journal of clinical psychiatry AU - Casey, D E AD - Mental Illness Research, Education & Clinical Center, Veterans Administration Medical Center, and the Oregon Health Sciences University, Portland 97201, USA. Y1 - 1998 PY - 1998 DA - 1998 SP - 31 EP - 37 VL - 59 Suppl 3 SN - 0160-6689, 0160-6689 KW - Clozapine KW - J60AR2IKIC KW - Index Medicus KW - Age Factors KW - Humans KW - Aged KW - Suicide -- statistics & numerical data KW - Substance-Related Disorders -- prevention & control KW - Risk Factors KW - Treatment Outcome KW - Substance-Related Disorders -- drug therapy KW - Middle Aged KW - Treatment Refusal KW - Basal Ganglia Diseases -- epidemiology KW - Female KW - Male KW - Suicide -- prevention & control KW - Basal Ganglia Diseases -- chemically induced KW - Prevalence KW - Clozapine -- therapeutic use KW - Dyskinesia, Drug-Induced -- epidemiology KW - Schizophrenia -- drug therapy KW - Dyskinesia, Drug-Induced -- etiology KW - Clozapine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79782454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Effects+of+clozapine+therapy+in+schizophrenic+individuals+at+risk+for+tardive+dyskinesia.&rft.au=Casey%2C+D+E&rft.aulast=Casey&rft.aufirst=D&rft.date=1998-01-01&rft.volume=59+Suppl+3&rft.issue=&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-04-10 N1 - Date created - 1998-04-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of neonatal sympathectomy on the development of structural vascular changes in angiotensin II-treated rats. AN - 79769750; 9533420 AB - In a previous study, we found that neonatal sympathectomy prevented the development of angiotensin II (ANG II)-induced hypertension but not the development of structural changes in small mesenteric arteries. To investigate further the dissociation between hypertension and structural vascular changes in sympathectomized ANG II-treated rats by extending morphometric measurements to include all segments of the mesenteric arterial tree. Neonatally sympathectomized and sham-sympathectomized male Sprague-Dawley rats, aged 34 months, were administered 200 ng/kg per min ANG II subcutaneously for 4 weeks. Sham-operated sympathectomized and sham-sympathectomized rats were controls. At the end of the treatment period the mesenteric circulation of rats was perfusion-fixed for morphometric measurements. Tail systolic blood pressure in ANG II-treated sham-sympathectomized rats increased by 47 mmHg (P < 0.001); the increase of systolic blood pressure (11 mmHg) in ANG II-treated sympathectomized rats did not attain statistical significance. Sympathectomy alone increased the lumen and reduced the wall : lumen ratio of first- and second-order branches of the superior mesenteric artery (hypotrophic outward remodeling). ANG II treatment increased the dimensions, wall thickness, and wall area of first- and second-order arteries (hypertrophic outward remodeling) and the wall : lumen ratio of small resistance arteries in sham-sympathectomized rats. Neonatal sympathectomy attenuated the development of structural changes in large arteries but had no effect on the development of structural changes in small arteries of ANG II-treated rats. Hypertension and sympathetic innervation appear to be contributing to the development of structural changes in large arteries of ANG II-treated rats because sympathectomy attenuated these changes. Structural changes in small arteries, on the other hand, appear to be due to a direct trophic effect of ANG II. JF - Journal of hypertension AU - Simon, G AU - Csiky, B AD - Department of Medicine, Veterans Administration Medical Center and University of Minnesota, Minneapolis 55417, USA. Y1 - 1998/01// PY - 1998 DA - January 1998 SP - 77 EP - 84 VL - 16 IS - 1 SN - 0263-6352, 0263-6352 KW - Angiotensin II KW - 11128-99-7 KW - Index Medicus KW - Rats KW - Animals, Newborn KW - Animals KW - Rats, Sprague-Dawley KW - Hypertrophy KW - Blood Pressure -- drug effects KW - Male KW - Hypertension -- chemically induced KW - Sympathetic Nervous System -- physiology KW - Hypertension -- prevention & control KW - Hypertension -- pathology KW - Mesenteric Arteries -- physiopathology KW - Mesenteric Arteries -- drug effects KW - Angiotensin II -- pharmacology KW - Sympathectomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79769750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hypertension&rft.atitle=Effect+of+neonatal+sympathectomy+on+the+development+of+structural+vascular+changes+in+angiotensin+II-treated+rats.&rft.au=Simon%2C+G%3BCsiky%2C+B&rft.aulast=Simon&rft.aufirst=G&rft.date=1998-01-01&rft.volume=16&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Journal+of+hypertension&rft.issn=02636352&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-05-28 N1 - Date created - 1998-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Benefits and drawbacks to hormone replacement therapy among nursing home patients. AN - 79731533; 9504039 JF - Women's health issues : official publication of the Jacobs Institute of Women's Health AU - Bosworth, H B AU - Bastian, L A AU - Siegler, I C AD - Durham Veterans Administration, Department of Medicine, North Carolina, USA. PY - 1998 SP - 53 EP - 59 VL - 8 IS - 1 SN - 1049-3867, 1049-3867 KW - Index Medicus KW - Age Factors KW - Attitude of Health Personnel KW - Attitude to Health KW - Humans KW - Patient Advocacy KW - Aged KW - Pilot Projects KW - Pharmacists KW - Coronary Disease -- prevention & control KW - Endometrial Neoplasms -- chemically induced KW - Aged, 80 and over KW - Risk Factors KW - Middle Aged KW - Long-Term Care KW - Breast Neoplasms -- chemically induced KW - Osteoporosis, Postmenopausal -- prevention & control KW - Female KW - Memory Disorders -- prevention & control KW - Estrogen Replacement Therapy -- adverse effects KW - Nursing Homes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79731533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+health+issues+%3A+official+publication+of+the+Jacobs+Institute+of+Women%27s+Health&rft.atitle=Benefits+and+drawbacks+to+hormone+replacement+therapy+among+nursing+home+patients.&rft.au=Bosworth%2C+H+B%3BBastian%2C+L+A%3BSiegler%2C+I+C&rft.aulast=Bosworth&rft.aufirst=H&rft.date=1998-01-01&rft.volume=8&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Women%27s+health+issues+%3A+official+publication+of+the+Jacobs+Institute+of+Women%27s+Health&rft.issn=10493867&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-03-27 N1 - Date created - 1998-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of the fixed combination of enalapril/diltiazem ER and their monotherapies in stage 1 to 3 essential hypertension. AN - 79726983; 9504446 AB - The safety and efficacy of two fixed dose combinations of enalapril and diltiazem extended release formation (ER) (E/D) were compared with their monotherapies and placebo in patients with stage 1 to 3 hypertension. The trial design was a multicenter, randomized, double blind, placebo controlled, parallel group, 12 week treatment phase, followed by a 36 week, open label phase. A total of 891 patients with sitting diastolic blood pressure (SiDBP) between 95 and 115 mm Hg were randomly assigned to enalapril 5 mg, diltiazem ER 120 mg, diltiazem ER 180 mg, enalapril 5 mg/diltiazem ER 120 mg (E5/D120), enalapril 5 mg/ diltiazem ER 180 mg (E5/D180), or placebo. In the open label phase, 562 patients received the fixed combination, titrated as needed to control SiDBP < 90 mm Hg. Efficacy was determined with trough (24 +/- 2 h postdose) sitting blood pressure measurements at week 12 and at the end of the open label part of the study. Safety was evaluated based on patient symptoms, clinical laboratories, and electrocardiograms (ECG). E5/D120 and E5/D180 significantly reduced trough SiDBP (-7.6 and -8.3 mm Hg, respectively; P < .05) versus their monotherapies. E5/D120 and E5/D180 significantly reduced trough sitting systolic blood pressure (-7.9 and -9.0, respectively; P < .05) versus both diltiazem ER monotherapies. All active treatments significantly decreased SiDBP and SiSBP versus placebo. E/D effectively lowered SiDBP and SiSBP during the open label extension. No significant difference was seen among treatment groups for the overall incidence of adverse events. The most common drug related adverse events were headache, edema/swelling, dizziness, asthenia/fatigue, cough, rash, and impotence. The event frequency for the combinations were similar to those seen with the monotherapies. Fixed combinations of E/D were generally well tolerated, with an increased blood pressure lowering effect as compared with the individual components in patients with stage I to III hypertension. JF - American journal of hypertension AU - Cushman, W C AU - Cohen, J D AU - Jones, R P AU - Marbury, T C AU - Rhoades, R B AU - Smith, L K AD - University of Tennessee College of Medicine, Veterans Affairs Medical Center, Memphis 38104-2193, USA. cushman@memphis.va.gov Y1 - 1998/01// PY - 1998 DA - January 1998 SP - 23 EP - 30 VL - 11 IS - 1 Pt 1 SN - 0895-7061, 0895-7061 KW - Antihypertensive Agents KW - 0 KW - Drug Combinations KW - Enalapril KW - 69PN84IO1A KW - Diltiazem KW - EE92BBP03H KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Adult KW - Aged KW - Outcome Assessment (Health Care) KW - Middle Aged KW - Blood Pressure -- drug effects KW - Male KW - Female KW - Diltiazem -- administration & dosage KW - Enalapril -- therapeutic use KW - Antihypertensive Agents -- adverse effects KW - Antihypertensive Agents -- therapeutic use KW - Antihypertensive Agents -- administration & dosage KW - Enalapril -- adverse effects KW - Enalapril -- administration & dosage KW - Diltiazem -- therapeutic use KW - Hypertension -- drug therapy KW - Diltiazem -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79726983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hypertension&rft.atitle=Comparison+of+the+fixed+combination+of+enalapril%2Fdiltiazem+ER+and+their+monotherapies+in+stage+1+to+3+essential+hypertension.&rft.au=Cushman%2C+W+C%3BCohen%2C+J+D%3BJones%2C+R+P%3BMarbury%2C+T+C%3BRhoades%2C+R+B%3BSmith%2C+L+K&rft.aulast=Cushman&rft.aufirst=W&rft.date=1998-01-01&rft.volume=11&rft.issue=1+Pt+1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hypertension&rft.issn=08957061&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-04-08 N1 - Date created - 1998-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In situ hybridization in the study of remodeling in proliferative glomerulonephritis. AN - 79723082; 9502386 AB - In situ hybridization combined with immunohistochemistry provides a powerful tool to study the temporal and spatial relationships between cellular sources of mRNA and localization of translated protein in normal biologic and pathologic processes. In this symposium, techniques in probe selection for the detection of mRNA in normal kidney and renal disease were discussed. Examples of the application of in situ hybridization in the study of renal disease were demonstrated using a model of proliferative glomerulonephritis induced by habu snake venom. This model follows an accelerated course of remodeling involving mesangial cell migration, proliferation, and extracellular matrix synthesis. The cellular sources and temporal expression of 2 adhesive proteins, fibronectin and thrombospondin, known to have a role in cell remodeling during embryogenesis and wound healing, were examined and compared to mesangial cell behaviors during the course of habu venom-induced glomerulonephritis. Mesangial cell migration in early lesions was associated with thrombospondin and fibronectin derived from platelets or macrophages. Thrombospondin mRNA and protein peaked at 48 hr after habu venom and were associated with mesangial cell proliferation; but thrombospondin mRNA and protein declined at 72 hr when expression of collagen type IV and laminin mRNA and protein peaked. Mesangial cell expression of fibronectin first appeared at 48 hr, and peaked at 72 hr after habu venom. Thus, mesangial cell migration was associated with exogenous fibronectin and thrombospondin derived from platelets or macrophages. Mesangial cell expression of thrombospondin was associated with migration and proliferation, whereas, expression of fibronectin was associated with proliferation and matrix synthesis. These results suggest distinctive temporal and spatial roles for thrombospondin and fibronectin in remodeling during glomerulonephritis and illustrate the utility of in situ hybridization and immunohistochemistry in the detection of cellular sources of translated proteins. JF - Toxicologic pathology AU - Barnes, J L AD - The Medical Research Service, Audie Murphy Memorial Veterans Administration Hospital, San Antonio, Texas 78284, USA. PY - 1998 SP - 43 EP - 51 VL - 26 IS - 1 SN - 0192-6233, 0192-6233 KW - Crotalid Venoms KW - 0 KW - Fibronectins KW - RNA, Messenger KW - Thrombospondins KW - Index Medicus KW - Animals KW - Cell Division -- drug effects KW - Thrombospondins -- genetics KW - Fibronectins -- metabolism KW - Fibronectins -- genetics KW - Immunohistochemistry -- methods KW - Thrombospondins -- metabolism KW - Extracellular Matrix -- drug effects KW - Rats KW - Trimeresurus KW - RNA, Messenger -- metabolism KW - Crotalid Venoms -- toxicity KW - Cell Movement -- drug effects KW - Glomerulonephritis, Membranoproliferative -- pathology KW - In Situ Hybridization -- methods KW - Glomerular Mesangium -- pathology KW - Glomerular Mesangium -- drug effects KW - Kidney Glomerulus -- drug effects KW - Glomerulonephritis, Membranoproliferative -- chemically induced KW - Glomerular Mesangium -- metabolism KW - Kidney Glomerulus -- pathology KW - Kidney Glomerulus -- metabolism KW - Glomerulonephritis, Membranoproliferative -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79723082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=In+situ+hybridization+in+the+study+of+remodeling+in+proliferative+glomerulonephritis.&rft.au=Barnes%2C+J+L&rft.aulast=Barnes&rft.aufirst=J&rft.date=1998-01-01&rft.volume=26&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-04-09 N1 - Date created - 1998-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Indinavir-associated hepatitis in patients with advanced HIV infection. AN - 79703077; 9518018 JF - International journal of STD & AIDS AU - Vergis, E AU - Paterson, D L AU - Singh, N AD - Veterans Administration Medical Center, Pittsburgh, Pennsylvania 15240, USA. Y1 - 1998/01// PY - 1998 DA - January 1998 SP - 53 VL - 9 IS - 1 SN - 0956-4624, 0956-4624 KW - Anti-HIV Agents KW - 0 KW - Indinavir KW - 5W6YA9PKKH KW - Index Medicus KW - AIDS/HIV KW - Humans KW - Middle Aged KW - Male KW - HIV Infections -- complications KW - Chemical and Drug Induced Liver Injury KW - HIV Infections -- drug therapy KW - Anti-HIV Agents -- adverse effects KW - Indinavir -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79703077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+STD+%26+AIDS&rft.atitle=Indinavir-associated+hepatitis+in+patients+with+advanced+HIV+infection.&rft.au=Vergis%2C+E%3BPaterson%2C+D+L%3BSingh%2C+N&rft.aulast=Vergis&rft.aufirst=E&rft.date=1998-01-01&rft.volume=9&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=International+journal+of+STD+%26+AIDS&rft.issn=09564624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-03-24 N1 - Date created - 1998-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Resistance to thyroid hormone: implications for neurodevelopmental research on the effects of thyroid hormone disruptors. AN - 79680114; 9460171 AB - Thyroid hormones are essential for normal behavioral, intellectual, and neurological development. Congenital hypothyroidism, if not treated, can result in irreversible mental retardation, whereas thyroid diseases with more moderate impairment of thyroid function, such as resistance to thyroid hormone, cause less severe intellectual and behavioral abnormalities, including attention deficit hyperactivity disorder. There is increasing evidence that exposure to certain synthetic compounds, including dioxins and polychlorinated biphenyls (PCBs), during the perinatal period can also impair learning, memory, and attentional processes in offspring. Animal and human studies suggest that exposure to these environmental toxicants impair normal thyroid function. Although the precise mechanisms of action of the adverse effects these toxicants have on neurodevelopment have not yet been elucidated, it is possible that they are partially or predominantly mediated by alterations in hormone binding to the thyroid hormone receptor. The convergence of studies that examine the neurodevelopmental consequences of moderate impairment of thyroid function, such as is found in resistance to thyroid hormone, with those studies that demonstrate the adverse behavioral and cognitive effects of perinatal exposure to dioxins and PCBs serves to generate new hypotheses to test in a research setting. Such studies may provide new insights into the basic pathogenesis of developmental neurotoxicity following exposure to thyroid-disrupting synthetic compounds. JF - Toxicology and industrial health AU - Hauser, P AU - McMillin, J M AU - Bhatara, V S AD - Department of Psychiatry, University of Maryland Medical Center, Baltimore, USA. Hauser.Peter@Baltimore.va.gov PY - 1998 SP - 85 EP - 101 VL - 14 IS - 1-2 SN - 0748-2337, 0748-2337 KW - Dioxins KW - 0 KW - Thyroid Hormones KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Rats KW - Infant KW - Animals KW - Humans KW - Infant, Newborn KW - Child Development -- drug effects KW - Neurosecretory Systems -- growth & development KW - Attention Deficit Disorder with Hyperactivity -- etiology KW - Female KW - Prenatal Exposure Delayed Effects KW - Pregnancy KW - Child, Preschool KW - Dioxins -- adverse effects KW - Thyroid Hormones -- pharmacology KW - Thyroid Gland -- drug effects KW - Child Behavior Disorders -- etiology KW - Thyroid Hormone Resistance Syndrome -- etiology KW - Thyroid Hormones -- metabolism KW - Thyroid Hormone Resistance Syndrome -- physiopathology KW - Polychlorinated Biphenyls -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79680114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=Resistance+to+thyroid+hormone%3A+implications+for+neurodevelopmental+research+on+the+effects+of+thyroid+hormone+disruptors.&rft.au=Hauser%2C+P%3BMcMillin%2C+J+M%3BBhatara%2C+V+S&rft.aulast=Hauser&rft.aufirst=P&rft.date=1998-01-01&rft.volume=14&rft.issue=1-2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-03-04 N1 - Date created - 1998-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - All-trans retinoic acid blocks the antiproliferative prodifferentiating actions of 1,25-dihydroxyvitamin D3 in normal human keratinocytes. AN - 79628350; 9397150 AB - 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] and all-trans retinoic acid (RA), the active metabolites of vitamins D and A respectively, regulate the proliferation and differentiation of keratinocytes. Both the vitamin D receptor (VDR) and the retinoic acid receptor family (RAR) bind to DNA response elements as heterodimers with the retinoic X receptor (RXR), suggesting that there are pathways of action that are shared by both compounds. Therefore, we examined the interactions of 1,25(OH)2D3 and RA upon the proliferation and differentiation of normal human keratinocytes (NHK) and of a squamous cell carcinoma cell line, SCC4. Although both 1,25(OH)2D3 and RA were each able to inhibit NHK proliferation in a dose-dependent manner, when they were administered in combination, proliferation was stimulated, suggesting mutual antagonism. In contrast, SCC4 cells proved insensitive in terms of proliferation to 1,25(OH)2D3 and to all but the highest concentration (10(-6) M) of RA. 1,25(OH)2D3 exerted a biphasic effect on transglutaminase (TGase) and involucrin (INV) mRNA levels, with maximal stimulation at 10(-9) M. RA inhibited TGase and INV mRNA levels and antagonized the stimulation by 1,25(OH)2D3. A similar pattern was observed for TGase protein, but, RA, which, by itself, reduced INV, markedly enhanced the ability of 1,25(OH)2D3 to raise INV levels, possibly by inhibiting 1,25(OH)2D3-stimulated TGase activity and cross-linking of soluble INV into the insoluble cornified envelope (CE). Thus, in NHK cells, RA antagonizes the antiproliferative prodifferentiating actions of 1,25(OH)2D3, but assessment of a single marker, such as INV protein, may be misleading. JF - Journal of cellular physiology AU - Gibson, D F AU - Bikle, D D AU - Harris, J AD - Department of Dermatology, Veterans Administration Medical Center, San Francisco, California, USA. Y1 - 1998/01// PY - 1998 DA - January 1998 SP - 1 EP - 8 VL - 174 IS - 1 SN - 0021-9541, 0021-9541 KW - Keratolytic Agents KW - 0 KW - Tretinoin KW - 5688UTC01R KW - Calcitriol KW - FXC9231JVH KW - Index Medicus KW - Cells, Cultured KW - Humans KW - Cell Division -- drug effects KW - Drug Antagonism KW - Cell Differentiation -- drug effects KW - Tretinoin -- pharmacology KW - Keratinocytes -- drug effects KW - Keratolytic Agents -- pharmacology KW - Keratinocytes -- cytology KW - Calcitriol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79628350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=All-trans+retinoic+acid+blocks+the+antiproliferative+prodifferentiating+actions+of+1%2C25-dihydroxyvitamin+D3+in+normal+human+keratinocytes.&rft.au=Gibson%2C+D+F%3BBikle%2C+D+D%3BHarris%2C+J&rft.aulast=Gibson&rft.aufirst=D&rft.date=1998-01-01&rft.volume=174&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=00219541&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-12-30 N1 - Date created - 1997-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sertraline treatment of mood disorder associated with prednisone: a case report. AN - 70124777; 9853693 AB - The use of corticosteroids, particularly high-potency steroids, for the treatment of various inflammatory conditions has been frequently associated with mood disturbance and psychosis. We report on a 12-year-old white boy treated with high doses of prednisone chronically for 7 years who presented with severe depression, irritability, violence, and psychosis. Sertraline was used to treat depressive as well as psychotic symptoms without the use of antipsychotics. This successful treatment of steroid-induced mood disorder and psychosis with a serotonin reuptake inhibitor is consistent with the literature describing a decrease in central and peripheral serotonin secretion due to steroids, as well as a possible relationship between mood and psychotic symptoms and low cerebrospinal fluid serotonin levels. JF - Journal of child and adolescent psychopharmacology AU - Beshay, H AU - Pumariega, A J AD - James H. Quillen College of Medicine, East Tennessee State University, Quillen/Mountain Home Veterans Administration Medical Center, Johnson City 37684, USA. Y1 - 1998 PY - 1998 DA - 1998 SP - 187 EP - 193 VL - 8 IS - 3 SN - 1044-5463, 1044-5463 KW - Anti-Inflammatory Agents KW - 0 KW - Antidepressive Agents, Second-Generation KW - Sertraline KW - QUC7NX6WMB KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Psychoses, Substance-Induced -- drug therapy KW - Psychiatric Status Rating Scales KW - Humans KW - Psychoses, Substance-Induced -- psychology KW - Child KW - Colitis, Ulcerative -- drug therapy KW - Male KW - Prednisone -- adverse effects KW - Sertraline -- therapeutic use KW - Antidepressive Agents, Second-Generation -- therapeutic use KW - Prednisone -- therapeutic use KW - Anti-Inflammatory Agents -- adverse effects KW - Anti-Inflammatory Agents -- therapeutic use KW - Mood Disorders -- drug therapy KW - Mood Disorders -- chemically induced KW - Mood Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70124777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+child+and+adolescent+psychopharmacology&rft.atitle=Sertraline+treatment+of+mood+disorder+associated+with+prednisone%3A+a+case+report.&rft.au=Beshay%2C+H%3BPumariega%2C+A+J&rft.aulast=Beshay&rft.aufirst=H&rft.date=1998-01-01&rft.volume=8&rft.issue=3&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Journal+of+child+and+adolescent+psychopharmacology&rft.issn=10445463&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-03-16 N1 - Date created - 1999-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of LAAM dose on opiate use in opioid-dependent patients. A pilot study. AN - 70045224; 9809131 AB - The authors conducted a 16-week study with nine opioid-dependent individuals (six male; four white/two African American/three Hispanic; age 36.8 +/- 2.2 years). Participants were assigned to either a low-dose (165 mg/week; n = 5) or high-dose (330 mg/week; n = 4) Levo-alpha-acetylmethadol (LAAM) condition according to a randomized, double-blind, within-subjects crossover design, such that they were inducted onto one maintenance dose for 4 weeks and then were crossed over to receive the converse for 4 weeks. Subsequently, individuals underwent detoxification from LAAM. Eight of nine participants completed the study protocol. The proportion of urine samples positive for opiates was 0.22 +/- 0.08 and 0.53 +/- 0.12, under the high- and low-dose conditions, respectively (F = 11.8; P = 0.01). These results show that LAAM dose regimen affects the degree of abstinence from opioids. JF - The American journal on addictions AU - Oliveto, A H AU - Farren, C AU - Kosten, T R AD - Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA. oliveto.alison_h@west-haven.va.gov Y1 - 1998 PY - 1998 DA - 1998 SP - 272 EP - 282 VL - 7 IS - 4 SN - 1055-0496, 1055-0496 KW - Narcotics KW - 0 KW - Methadyl Acetate KW - L59OC40KWJ KW - Index Medicus KW - Substance Withdrawal Syndrome KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Pilot Projects KW - Male KW - Female KW - Methadyl Acetate -- administration & dosage KW - Narcotics -- urine KW - Narcotics -- therapeutic use KW - Narcotics -- administration & dosage KW - Methadyl Acetate -- therapeutic use KW - Opioid-Related Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70045224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Effect+of+LAAM+dose+on+opiate+use+in+opioid-dependent+patients.+A+pilot+study.&rft.au=Oliveto%2C+A+H%3BFarren%2C+C%3BKosten%2C+T+R&rft.aulast=Oliveto&rft.aufirst=A&rft.date=1998-01-01&rft.volume=7&rft.issue=4&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1999-01-29 N1 - Date created - 1999-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanism of acid-induced mesenteric hyperemia in rats. AN - 70029913; 9806218 AB - The mesenteric hyperemia induced by intraduodenal application of hydrochloric acid (HCl) is mediated in part by capsaicin-sensitive afferent nerves. Antagonist of capsaicin-sensitive receptors (capsazepine) and blocker of capsaicin-sensitive cation channels (ruthenium red) have been described. We employed these tools to dissect the mechanism of regulation of mesenteric hyperemia induced by intraduodenal administration of HCl. Subcutaneous 100 micromol/kg capsazepine or intraduodenal 0.1% ruthenium red was administered to pentobarbital anesthetized rats. Then, 2.5 ml/kg of 640 microM capsaicin or 0.1 N HCl was administered intraduodenally. The mesenteric hyperemic responses were recorded. The results demonstrated that in a dose that decreased the mesenteric hyperemia induced by intraduodenal capsaicin, capsazepine failed to attenuate the mesenteric vasodilatory effect of intraduodenal HCl. Ruthenium red significantly attenuated the mesenteric hyperemia after intraduodenal capsaicin and HCl. These in vivo data provide the first functional evidence for the existence of capsazepine-sensitive capsaicin receptors and cation channel complexes in the rat duodenal and intestinal mucosa. The capsaicin- and HCl-sensitive receptors are unlikely to be functionally identical in these locations. The ruthenium red-sensitive cation channels appear to mediate the capsaicin- and HCl-induced mesenteric hyperemia. JF - Life sciences AU - Seno, K AU - Iwata, F AU - Lam, K AU - Leung, J W AU - Leung, F W AD - Research and Medical Services, Sepulveda Veterans Administration Medical Center, California 91343, USA. Y1 - 1998 PY - 1998 DA - 1998 SP - 1653 EP - 1662 VL - 63 IS - 18 SN - 0024-3205, 0024-3205 KW - Ruthenium Red KW - 11103-72-3 KW - capsazepine KW - LFW48MY844 KW - Hydrochloric Acid KW - QTT17582CB KW - Capsaicin KW - S07O44R1ZM KW - Index Medicus KW - Animals KW - Blood Pressure -- physiology KW - Hydrochloric Acid -- antagonists & inhibitors KW - Duodenum -- blood supply KW - Laser-Doppler Flowmetry KW - Capsaicin -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Ruthenium Red -- pharmacology KW - Capsaicin -- analogs & derivatives KW - Capsaicin -- antagonists & inhibitors KW - Male KW - Regional Blood Flow -- physiology KW - Hyperemia -- chemically induced KW - Hyperemia -- prevention & control KW - Mesenteric Arteries -- physiopathology KW - Hyperemia -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70029913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Mechanism+of+acid-induced+mesenteric+hyperemia+in+rats.&rft.au=Seno%2C+K%3BIwata%2C+F%3BLam%2C+K%3BLeung%2C+J+W%3BLeung%2C+F+W&rft.aulast=Seno&rft.aufirst=K&rft.date=1998-01-01&rft.volume=63&rft.issue=18&rft.spage=1653&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-11-16 N1 - Date created - 1998-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Stepfamilies in Later Life: Relationships between the Generations T2 - International Sociological Association AN - 61746467; 98S36414 AB - Examines the long-term consequences of remarriage on intergenerational relationships, drawing on in-depth interviews with biological & stepmothers & fathers of adult children from previous marriages (N = 36 families). Within a life-course framework, each spouse looked back on the structural & emotional histories of their relationships with children & stepchildren. Analysis suggested factors implicated in patterns of intergenerational relationships in older stepfamilies, eg, older fathers' lack of engagement with their "ex-children" from previous marriages, stepmothers' behavior as "family carpenters" for damaged relationships, older stepfathers' extreme stances toward their adult stepchildren, & older mothers' retention of close intergenerational ties. The families illustrate the complexity, diversity, difficulty, & resiliency inherent in the stepfamily experience. JF - International Sociological Association AU - Vinick, Barbara H Y1 - 1998///0, PY - 1998 DA - 0, 1998 KW - Intergenerational Relations KW - Stepfamily KW - Parent Child Relations KW - proceeding KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61746467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=International+Sociological+Association&rft.atitle=Stepfamilies+in+Later+Life%3A+Relationships+between+the+Generations&rft.au=Vinick%2C+Barbara+H&rft.aulast=Vinick&rft.aufirst=Barbara&rft.date=1998-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+Sociological+Association&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2009-03-10 N1 - Publication note - 1998 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Ventilator-associated pneumonia AN - 17299220; 4560914 AB - Mechanically ventilated patients are at a substantially higher risk for developing nosocomial pneumonia. Overall, there is a relatively constant 1&!TN!150; 3% risk per day of developing pneumonia while receiving mechanical ventilation. The sensitivity and specificity of clinical criteria alone for diagnosis of ventilator-associated pneumonias (VAP) is low. Several techniques have been developed to sample and quantitate the lower respiratory tract to improve the diagnostic yield. Gram-negative bacillary pneumonias account for the majority of the VAP. Strategies for prevention of VAP such as use of sucralfate for stress ulcer prophylaxis and selective decontamination of the digestive tract have been the focus of many clinical studies. Cost-effective preventive measures are needed to combat the increasing antimicrobial resistance, growing population of immunocompromised patients and increasing number of mechanically ventilated patients. JF - International Journal of Antimicrobial Agents AU - Visnegarwala, F AU - Iyer, NG AU - Hamill, R J AD - Section of Infectious Diseases (111G), Veterans Affairs Medical Center, 2002 Holcombe Blvd., Houston, TX 77030-4211, USA, hamill.richard_j@houston.va.gov Y1 - 1998 PY - 1998 DA - 1998 SP - 191 EP - 205 VL - 10 IS - 3 SN - 0924-8579, 0924-8579 KW - man KW - ventilators KW - Microbiology Abstracts B: Bacteriology KW - Diagnosis KW - Digestive tract KW - Gram-negative bacilli KW - Nosocomial infection KW - Pneumonia KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17299220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Antimicrobial+Agents&rft.atitle=Ventilator-associated+pneumonia&rft.au=Visnegarwala%2C+F%3BIyer%2C+NG%3BHamill%2C+R+J&rft.aulast=Visnegarwala&rft.aufirst=F&rft.date=1998-01-01&rft.volume=10&rft.issue=3&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Antimicrobial+Agents&rft.issn=09248579&rft_id=info:doi/10.1016%2FS0924-8579%2898%2900037-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Digestive tract; Nosocomial infection; Gram-negative bacilli; Diagnosis; Pneumonia DO - http://dx.doi.org/10.1016/S0924-8579(98)00037-5 ER - TY - JOUR T1 - Successful treatment of primary Actinomyces viscosus endocarditis with third-generation cephalosporins AN - 16540859; 4350781 JF - Clinical Infectious Diseases AU - Hamed, KA AD - Section of Infectious Diseases, Bay Pines Veterans Administration Medical Center 111J, 10,000 Veterans Boulevard, Bay Pines, FL 33744, USA Y1 - 1998/01// PY - 1998 DA - Jan 1998 SP - 211 EP - 212 VL - 26 IS - 1 SN - 1058-4838, 1058-4838 KW - beta -Lactam antibiotics KW - cephalosporins KW - man KW - Microbiology Abstracts B: Bacteriology KW - Endocarditis KW - Heart diseases KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16540859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Successful+treatment+of+primary+Actinomyces+viscosus+endocarditis+with+third-generation+cephalosporins&rft.au=Hamed%2C+KA&rft.aulast=Hamed&rft.aufirst=KA&rft.date=1998-01-01&rft.volume=26&rft.issue=1&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Heart diseases; Endocarditis ER - TY - JOUR T1 - Synchronous adenomas in a colonic interposition graft and the native colon. AN - 85213862; pmid-9399777 JF - The American Journal of Gastroenterology AU - Kovacs, B J AU - Griffin, R A AU - Chen, Y K AD - Division of Gastroenterology, Jerry L. Pettis Veterans Administration Medical Center and Loma Linda University School of Medicine, California 92350, USA. PY - 1997 SP - 2303 EP - 2304 VL - 92 IS - 12 SN - 0002-9270, 0002-9270 KW - Anastomosis, Surgical KW - Colon KW - Esophagectomy KW - Esophageal Stenosis KW - Human KW - Colonic Polyps KW - Aged KW - Case Report KW - Adenoma KW - Colonic Neoplasms KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85213862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Synchronous+adenomas+in+a+colonic+interposition+graft+and+the+native+colon.&rft.au=Kovacs%2C+B+J%3BGriffin%2C+R+A%3BChen%2C+Y+K&rft.aulast=Kovacs&rft.aufirst=B&rft.date=1997-12-01&rft.volume=92&rft.issue=12&rft.spage=2303&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Paclitaxel, cisplatin, and 5-fluorouracil in patients with advanced or recurrent squamous cell carcinoma of the head and neck: a preliminary report. AN - 79499383; 9427265 AB - The combination of 5-fluorouracil (5-FU) and cisplatin is considered the most active chemotherapy for patients with recurrent squamous cell carcinoma of the head and neck (SCCHN), with an overall response rate of 30%. Paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) has demonstrated activity in SCCHN and synergy with cisplatin. To augment the activity of the combination of 5-FU and cisplatin, a pilot study was designed to determine the feasibility of combining 3-hour infusional paclitaxel with 5-FU and cisplatin. To be eligible, patients had to have recurrent or advanced SCCHN with measurable or evaluable disease and no prior chemotherapy. A minimum of three courses had to be delivered to determine cumulative toxicity. The starting dose level consisted of paclitaxel 135 mg/m2 on day 1, cisplatin 75 mg/m2 on day 2, and 5-FU 1 g/m2 on days 2 through 6. The first treated patient developed grade 4 mucositis, which resulted in reducing dose level 1 of 5-FU to 800 mg/m2/d on days 2 through 6 (seven patients); subsequently, the 5-FU dose was adjusted to 1 g/m2/d on days 2 through 5 (nine patients). To date, 17 patients have been enrolled, with a median age of 62 years (range, 48 to 75 years). Of the 17 patients, nine had recurrent disease following prior surgery and/or radiotherapy and eight had previously untreated advanced SCCHN. Major toxicities were neutropenia and mucositis. There were four early deaths (two treatment-related and two cancer-related). Forty-seven courses of therapy were delivered, with a median of two (range, one to five). The overall response rate in 14 response-evaluable patients was 71% (10 of 14 patients; eight partial and two complete responses). Five of seven response-evaluable patients with recurrent disease had major responses (one complete and four partial responses). At the current dose, the combination of paclitaxel/5-FU/cisplatin is feasible and shows very encouraging activity, particularly in patients with recurrent SCCHN. JF - Seminars in oncology AU - Hussain, M AU - Salwen, W AU - Kucuk, O AU - Ensley, J AD - Department of Surgery, Veterans Administration Medical Center, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA. Y1 - 1997/12// PY - 1997 DA - December 1997 SP - S19 EP - 43-S19-45 VL - 24 IS - 6 Suppl 19 SN - 0093-7754, 0093-7754 KW - Paclitaxel KW - P88XT4IS4D KW - Cisplatin KW - Q20Q21Q62J KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Drug Administration Schedule KW - Humans KW - Aged KW - Pilot Projects KW - Cisplatin -- administration & dosage KW - Fluorouracil -- administration & dosage KW - Paclitaxel -- toxicity KW - Fluorouracil -- toxicity KW - Cisplatin -- toxicity KW - Middle Aged KW - Neoplasm Recurrence, Local KW - Female KW - Male KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Head and Neck Neoplasms -- drug therapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79499383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+oncology&rft.atitle=Paclitaxel%2C+cisplatin%2C+and+5-fluorouracil+in+patients+with+advanced+or+recurrent+squamous+cell+carcinoma+of+the+head+and+neck%3A+a+preliminary+report.&rft.au=Hussain%2C+M%3BSalwen%2C+W%3BKucuk%2C+O%3BEnsley%2C+J&rft.aulast=Hussain&rft.aufirst=M&rft.date=1997-12-01&rft.volume=24&rft.issue=6+Suppl+19&rft.spage=S19&rft.isbn=&rft.btitle=&rft.title=Seminars+in+oncology&rft.issn=00937754&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-01-28 N1 - Date created - 1998-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of halothane on the phrenic nerve responses to carbon dioxide mediated by carotid body chemoreceptors in vagotomized dogs. AN - 79495977; 9416729 AB - Previous studies in dogs showed that the phrenic nerve response to an acute hypoxic stimulus was dose dependently depressed by 0.5-2.0 minimum alveolar concentration (MAC) of halothane but not abolished. Because a carbon dioxide stimulus is transduced by a different mechanism in the carotid body chemoreceptors (CBCRs) than is a hypoxic stimulus, inhalational anesthetics may preferentially depress one of these transduction processes, the central neuronal processing, or both, of the integrated responses to these two types of inputs. Carotid body chemoreceptor stimulation was produced by short (1-1.5 s), bilateral, 100% carbon dioxide in saline infusions into the carotid arteries during neural inspiration in unpremedicated, halothane-anesthetized, paralyzed, vagotomized dogs during constant mechanical ventilation. The phrenic neurogram quantified the neural inspiratory response. Four protocols were performed in the study: (1) the dose-dependent effects of halothane anesthesia (0.5-2.0 MAC) during hyperoxic hypercapnia on phrenic nerve activity, (2) the effects of three background levels of the partial pressure of carbon dioxide (PaCO2) on the magnitude of the carbon dioxide infusion responses at 1 MAC halothane, (3) the effects of anesthetic type on the magnitude of the carbon dioxide infusion response, and (4) the effects of CBCR denervation. Peak phrenic nerve activity (PPA) increased significantly during the carbon dioxide-stimulated phrenic burst in protocols 1-3; after denervation there was no response (protocol 4). Halothane produced a dose-dependent reduction in the PPA of control and carbon dioxide infusion-stimulated phrenic bursts and in the net carbon dioxide response. The net PPA responses for the different PaCO2 background levels were not different but were somewhat larger for sodium thiopental anesthesia than for 1.0 MAC halothane. The phrenic nerve response to an acute, severe carbon dioxide stimulus was dose dependently depressed by surgical doses of halothane. The observed responses to carbon dioxide infusion were mediated by the CBCRs because they were eliminated by CBCR denervation. These results suggest that the CBCR transduction and central transmission of the carbon dioxide signal in terms of inspiratory excitatory drive are not abolished at surgical levels of halothane anesthesia. JF - Anesthesiology AU - Stuth, E A AU - Dogas, Z AU - Krolo, M AU - Kampine, J P AU - Hopp, F A AU - Zuperku, E J AD - Department of Anesthesiology, Medical College of Wisconsin and Zablocki Veterans Administration Medical Center, Milwaukee 53295, USA. Y1 - 1997/12// PY - 1997 DA - December 1997 SP - 1440 EP - 1449 VL - 87 IS - 6 SN - 0003-3022, 0003-3022 KW - Anesthetics, Inhalation KW - 0 KW - Carbon Dioxide KW - 142M471B3J KW - Halothane KW - UQT9G45D1P KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Vagotomy KW - Dogs KW - Halothane -- pharmacology KW - Phrenic Nerve -- drug effects KW - Carotid Body -- physiology KW - Anesthetics, Inhalation -- pharmacology KW - Carotid Body -- drug effects KW - Phrenic Nerve -- physiology KW - Carbon Dioxide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79495977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesiology&rft.atitle=Effects+of+halothane+on+the+phrenic+nerve+responses+to+carbon+dioxide+mediated+by+carotid+body+chemoreceptors+in+vagotomized+dogs.&rft.au=Stuth%2C+E+A%3BDogas%2C+Z%3BKrolo%2C+M%3BKampine%2C+J+P%3BHopp%2C+F+A%3BZuperku%2C+E+J&rft.aulast=Stuth&rft.aufirst=E&rft.date=1997-12-01&rft.volume=87&rft.issue=6&rft.spage=1440&rft.isbn=&rft.btitle=&rft.title=Anesthesiology&rft.issn=00033022&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-01-15 N1 - Date created - 1998-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Metabolic differences and their impact on human disease: sulfotransferase and colorectal cancer AN - 17345068; 4562424 AB - Gene-environment interaction is an important aspect of human cancer risk. Genetic polymorphisms in acetylation and N-oxidation have previously been described regarding their impact on the heterocyclic amine-induced risk for colon cancer. Here, we report that another enzyme involved in the metabolism of food-borne carcinogens, sulfotransferase (ST1A3 measured by 2-naphthol activity), may function as a potential protective factor for colon cancer in humans. Initially characterized in human liver and colon (Chou et al., 1995), TS-PST activity can also be measured in platelets. A simple microtiter-based colorimetric technique was developed for use in this case-control study. African-Americans had a higher mean ST activity than Caucasians (2.32 plus or minus 0.24 versus 1.77 plus or minus 0.09 nmols/min per mg cytosolic protein, P = 0.036). Furthermore, the slow ST phenotype (ST less than or equal to 1.53) was more frequently associated with colon cancer than controls (57 versus 40%, P = 0.026). These data suggest that the ST1A3 isoform may play a role in the differential risk for colorectal cancer. JF - Environmental Toxicology and Pharmacology AU - Frame, L T AU - Gatlin, T L AU - Kadlubar, F F AU - Lang, N P Y1 - 1997/12// PY - 1997 DA - Dec 1997 SP - 277 EP - 281 PB - Elsevier Science Ltd., P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 4 IS - 3-4 KW - man KW - metabolic differences KW - sulfotransferase KW - Toxicology Abstracts KW - Genetics KW - Food KW - Colorectal KW - Carcinogens KW - Cancer KW - X 24120:Food, additives & contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17345068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Pharmacology&rft.atitle=Metabolic+differences+and+their+impact+on+human+disease%3A+sulfotransferase+and+colorectal+cancer&rft.au=Frame%2C+L+T%3BGatlin%2C+T+L%3BKadlubar%2C+F+F%3BLang%2C+N+P&rft.aulast=Frame&rft.aufirst=L&rft.date=1997-12-01&rft.volume=4&rft.issue=3-4&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Pharmacology&rft.issn=13826689&rft_id=info:doi/10.1016%2FS1382-6689%2897%2910023-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1016/S1382-6689(97)10023-0 ER - TY - JOUR T1 - Differential induction of Th1 versus Th2 cytokines by group A streptococcal toxic shock syndrome isolates AN - 16253132; 4233789 AB - The majority of group A streptococcal (GAS) isolates from patients with streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis (NF) express numerous virulence factors, including several superantigens (SAgs). Purified SAgs are potent inducers of inflammatory (Th1) cytokines that contribute to the pathogenesis of severe infections. However, GAS-infected individuals are likely to be exposed to a mixture of GAS SAgs as well as other virulence factors produced by the bacteria, and therefore, our goal was to characterize the mitogenic and cytokine induction profiles of this mixture. All GAS isolates tested had brisk mitogenic activity and induced potent cytokine responses, with higher frequencies of Th1 than Th2 cytokine-producing cells. The mitogenic activity produced in culture supernatants of three selected clinical GAS isolates was significantly different, but no marked difference was found in their overall cytokine induction profiles. However, significant differences (P < 0.0062) were noted in the induction of Th2 cytokines between GAS supernatants and recombinant streptococcal pyrogenic exotoxin A (rSpeA), suggesting that the presence of other SAgs and/or the production of additional virulence factors may alter the overall cytokine induction profile of SAgs. A significant individual variation in the level of proliferative and cytokine responses to the same GAS culture supernatants or to rSpeA was noted. Individuals with higher frequencies of cells producing Th2 cytokines mounted lower levels of Th1 cytokine responses, and vice versa. Furthermore, quantification of the intensity and cell area of interleukin-1 beta (IL-1 beta )-producing cells by image analysis revealed that individuals with higher Th2 responses had significantly lower IL-1 beta production (P < 0.0001) than the individual with a strong Th1 response. Differences in the ability to induce Th1 versus Th2 cytokines, as well as the individual variations in cytokine responses to streptococcal SAgs, may play a central role in determining the severity of invasive GAS infections. JF - Infection and Immunity AU - Norrby-Teglund, A AU - Lustig, R AU - Kotb, M AD - Veterans Administration Medical Center, Research Service 151, 1030 Jefferson Ave., Memphis, TN 38104, USA Y1 - 1997/12// PY - 1997 DA - Dec 1997 SP - 5209 EP - 5215 VL - 65 IS - 12 SN - 0019-9567, 0019-9567 KW - Streptococcus KW - cytokines KW - necrotizing fasciitis KW - toxic shock syndrome KW - virulence KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16253132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Differential+induction+of+Th1+versus+Th2+cytokines+by+group+A+streptococcal+toxic+shock+syndrome+isolates&rft.au=Norrby-Teglund%2C+A%3BLustig%2C+R%3BKotb%2C+M&rft.aulast=Norrby-Teglund&rft.aufirst=A&rft.date=1997-12-01&rft.volume=65&rft.issue=12&rft.spage=5209&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - An N-linked glycosylation motif from the noncleaving luteinizing hormone receptor substituted for the homologous region (Gly367 to Glu369) of the thyrotropin receptor prevents cleavage at its second, downstream site. AN - 79385316; 9353284 AB - The thyrotropin receptor (TSHR) exists in two forms (single polypeptide and two subunits), whereas the lutropin/chorionic gonadotropin receptor (LH/CGR) is a single chain. Recent data suggest that the TSHR cleaves at two sites. We mutagenized selected chimeric TSH-LH/CGR to localize the cleavage sites in the TSHR. All 23 receptors mutated in the estimated vicinity of the upstream site cleaved into two subunits as determined by 125I-TSH cross-linking to intact cells. In contrast, in a series of mutations homologous to the noncleaving LH/CGR, the downstream TSHR cleavage site localized to three amino acids (GQE367-369). Remarkably, group substitution of these residues, but not substitution of individual residues, abolished cleavage. Moreover, the mutation that prevented cleavage (GQE367-369NET) transposed a motif (NET291-293) that is glycosylated in the LH/CGR. TSHR cleavage or noncleavage after substitution of GQE367-369 with other triplets (AAA, NQE, and NQT) was consistent with a role for N-linked glycosylation at this site. In summary, our data (i) support the concept that the TSHR cleaves at two sites, (ii) relate TSHR residues GQE367-369 to cleavage at the second, downstream site, and (iii) suggest that cleavage or noncleavage at site two is related to N-linked glycosylation. These findings provide new insight into the evolutionary divergence of two closely related receptors. JF - The Journal of biological chemistry AU - Kakinuma, A AU - Chazenbalk, G D AU - Tanaka, K AU - Nagayama, Y AU - McLachlan, S M AU - Rapoport, B AD - Thyroid Molecular Biology Unit, Veterans Administration Medical Center and the University of California, San Francisco, California 94121, USA. Y1 - 1997/11/07/ PY - 1997 DA - 1997 Nov 07 SP - 28296 EP - 28300 VL - 272 IS - 45 SN - 0021-9258, 0021-9258 KW - Receptors, LH KW - 0 KW - Receptors, Thyrotropin KW - Recombinant Fusion Proteins KW - Glutamine KW - 0RH81L854J KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Recombinant Fusion Proteins -- metabolism KW - Mutagenesis, Site-Directed KW - Animals KW - Cattle KW - Glutamine -- metabolism KW - Glycine -- metabolism KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Glycosylation KW - Amino Acid Substitution KW - Recombinant Fusion Proteins -- chemistry KW - Protein Conformation KW - Receptors, Thyrotropin -- metabolism KW - Receptors, Thyrotropin -- chemistry KW - Receptors, LH -- chemistry KW - Receptors, LH -- genetics KW - Receptors, LH -- metabolism KW - Receptors, Thyrotropin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79385316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=An+N-linked+glycosylation+motif+from+the+noncleaving+luteinizing+hormone+receptor+substituted+for+the+homologous+region+%28Gly367+to+Glu369%29+of+the+thyrotropin+receptor+prevents+cleavage+at+its+second%2C+downstream+site.&rft.au=Kakinuma%2C+A%3BChazenbalk%2C+G+D%3BTanaka%2C+K%3BNagayama%2C+Y%3BMcLachlan%2C+S+M%3BRapoport%2C+B&rft.aulast=Kakinuma&rft.aufirst=A&rft.date=1997-11-07&rft.volume=272&rft.issue=45&rft.spage=28296&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-12-12 N1 - Date created - 1997-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical Assessment of Swallowing and Prediction of Dysphagia Severity AN - 85693696; 200003178 AB - A study to evaluate noninvasive methods for determining post-stroke patients' risk of developing aspiration is presented. Assessments of six clinical features via oropharyngeal exam & a water swallow test were compared to the results of videofluoroscopic swallow studies of patients (N = 59, aged 41-88). Results indicate that the presence of at least two of the six clinical features (dysphonia, dysarthria, abnormal volitional cough, abnormal gag reflex, cough after swallow, & voice change after swallow) accurately predicted increased risk of aspiration by distinguishing patients with moderate to severe dysphagia from those with less severe or no swallowing dysfunction. It is concluded that these data support the notion that clinical screening can provide objective criteria in order to assess the need for videofluoroscopic swallow studies in acute stroke patients. 1 Table, 1 Figure, 1 Appendix, 30 References. T. Rosenberg JF - American Journal of Speech-Language Pathology AU - Daniels, Stephanie K AU - McAdam, Colleen P AU - Brailey, Kevin AU - Foundas, Anne L AD - Dept Veteran Affairs Medical Center, New Orleans, LA daniels.stephanie_k@new-orleans.med.va.gov Y1 - 1997/11// PY - 1997 DA - November 1997 SP - 17 EP - 24 VL - 6 IS - 4 SN - 1058-0360, 1058-0360 KW - Respiratory System (73100) KW - Brain Damage (09400) KW - Speech Tests (83100) KW - Voice Disorders (95150) KW - Aspiration (05150) KW - Speech Therapy (83200) KW - article KW - 6210: hearing and speech physiology; hearing and speech physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85693696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Speech-Language+Pathology&rft.atitle=Clinical+Assessment+of+Swallowing+and+Prediction+of+Dysphagia+Severity&rft.au=Daniels%2C+Stephanie+K%3BMcAdam%2C+Colleen+P%3BBrailey%2C+Kevin%3BFoundas%2C+Anne+L&rft.aulast=Daniels&rft.aufirst=Stephanie&rft.date=1997-11-01&rft.volume=6&rft.issue=4&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Speech-Language+Pathology&rft.issn=10580360&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJSPFZ N1 - SubjectsTermNotLitGenreText - Voice Disorders (95150); Speech Tests (83100); Aspiration (05150); Brain Damage (09400); Respiratory System (73100); Speech Therapy (83200) ER - TY - JOUR T1 - Evidence that human Fc gamma receptor IIA (CD32) subtypes are not receptors for oxidized LDL. AN - 79491733; 9409319 AB - Several lines of evidence suggest that clearance of oxidized LDL (oxLDL) immune complexes by macrophage IgG Fc receptors (Fc gamma Rs) plays a role in atherogenesis. Ox-LDL may also be cleared directly by Fc gamma Rs, as shown for murine Fc gamma RII-B2. In humans, the homologous Fc gamma R is Fc gamma RIIA (CD32), which is abundantly expressed on monocytes and macrophages and shares 60% sequence identity with murine Fc gamma RII-B2. As murine Fc gamma RII-B2 and human Fc gamma RIIA also share similar IgG ligand-binding properties, the purpose of this study was to test the hypothesis that human CD32 is a receptor for oxLDL. For these studies we used transfected Chinese hamster ovary (CHO) cells, monocytes, and cell lines that functionally express either of two Fc gamma RIIA subtypes (R131 or H131) and assayed binding or degradation of several preparations of oxLDL. The integrity of all oxLDL preparations was checked by studying their ability to react with CHO cells expressing human type I scavenger receptors and by other characteristics of lipoprotein oxidation. Although we showed that each preparation of oxLDL could recognize class A or class B scavenger receptors, we did not detect any differences in the binding or degradation of any type of oxLDL preparation among control versus CHO cell transfectants. Using monocytes that express Fc gamma RIIA and CD36, we showed that the binding of oxLDL was inhibited by antibodies to CD36, but not by Fc gamma RIIA antibodies. Thus, the data do not support the hypothesis that human Fc gamma RIIA is by itself a receptor for oxLDL. We conclude that human CD32 can mediate uptake of lipoprotein immune complexes, but does not mediate uptake of oxLDL in the absence of anti-oxLDL antibodies. OxLDL may interact with human mononuclear phagocytes directly via other types of receptors, such as class A and class B scavenger receptors or CD68. JF - Arteriosclerosis, thrombosis, and vascular biology AU - Morganelli, P M AU - Groveman, D S AU - Pfeiffer, J R AD - Veterans Administration Hospital, White River Junction, VT 05009, USA. Peter.Morganelli@Dartmouth.edu Y1 - 1997/11// PY - 1997 DA - November 1997 SP - 3248 EP - 3254 VL - 17 IS - 11 SN - 1079-5642, 1079-5642 KW - Antigen-Antibody Complex KW - 0 KW - Antigens, CD36 KW - Lipoproteins, LDL KW - Membrane Proteins KW - Oxidants KW - Receptors, IgG KW - Receptors, Immunologic KW - Receptors, Lipoprotein KW - Receptors, Scavenger KW - Recombinant Fusion Proteins KW - SCARB1 protein, human KW - Scarb1 protein, mouse KW - Scavenger Receptors, Class A KW - Scavenger Receptors, Class B KW - oxidized low density lipoprotein KW - Copper KW - 789U1901C5 KW - Index Medicus KW - Animals KW - Cricetulus KW - Oxidants -- pharmacology KW - Humans KW - Antigen-Antibody Complex -- metabolism KW - Copper -- pharmacology KW - Protein Binding KW - Lipid Peroxidation KW - Recombinant Fusion Proteins -- metabolism KW - Oxidation-Reduction KW - Tumor Cells, Cultured KW - Transfection KW - Cells, Cultured KW - Receptors, Immunologic -- metabolism KW - Monocytes -- metabolism KW - CHO Cells KW - Cricetinae KW - Receptors, IgG -- classification KW - Receptors, IgG -- metabolism KW - Lipoproteins, LDL -- metabolism KW - Lipoproteins, LDL -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79491733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.atitle=Evidence+that+human+Fc+gamma+receptor+IIA+%28CD32%29+subtypes+are+not+receptors+for+oxidized+LDL.&rft.au=Morganelli%2C+P+M%3BGroveman%2C+D+S%3BPfeiffer%2C+J+R&rft.aulast=Morganelli&rft.aufirst=P&rft.date=1997-11-01&rft.volume=17&rft.issue=11&rft.spage=3248&rft.isbn=&rft.btitle=&rft.title=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.issn=10795642&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-01-22 N1 - Date created - 1998-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Liver LDL receptor mRNA expression is decreased in human ApoB/CETP double transgenic mice and is regulated by diet as well as the cytokine oncostatin M. AN - 79487268; 9409281 AB - We have investigated liver LDL receptor mRNA expression in nontransgenic, human cholesteryl ester transfer protein (CETP) transgenic, and human apolipoprotein (Apo) B/CETP double transgenic mice fed a normal chow diet and a high fat, high cholesterol diet (HFHC). Three weeks of HFHC feeding increased total serum cholesterol 1.5-fold in the nontransgenic, 3.1-fold in the CETP transgenic, and 3.4-fold in the ApoB/CETP double transgenic mice. To examine the liver LDL receptor mRNA expression among the different groups of mice fed the normal diet or fed the HFHC diet, we developed a quantitative reverse-transcribed polymerase chain reaction assay in which the LDL receptor mRNA level was normalized with the beta-actin mRNA. The results show that on the normal chow diet, the LDL receptor mRNA expression levels were lower in the ApoB/CETP mice than in the nontransgenic mice and the human CETP transgenic mice. Liver LDL receptor gene expression was lower in all groups of mice fed the HFHC diet, with the lowest level of expression in the ApoB/CETP mice. Similar results were obtained by Northern blot analysis. In addition, we have previously shown that the cytokine oncostatin M (OM) increases LDL receptor gene expression in HepG2 cells. In this study, we used the ApoB/CETP mice as the model system to examine the in vivo activity of OM on liver LDL receptor gene expression. Our data show that OM increased the level of liver LDL receptor mRNA up to 80% to 90% when the animals were fed the HFHC diet. The results from these studies demonstrate that the expression of the liver LDL receptor in the ApoB/CETP mice is suppressed compared with nontransgenic mice and that the expression of the hepatic LDL receptor gene in these mice is subjected to the normal cholesterol feedback regulation. In addition, LDL receptor gene expression in these mice is also inducible by a positive regulator. JF - Arteriosclerosis, thrombosis, and vascular biology AU - Liu, J AU - Zhang, Y L AU - Spence, M J AU - Vestal, R E AU - Wallace, P M AU - Grass, D S AD - Department of Veterans Affairs Medical Center, Boise, Idaho, USA. Liu@icon.Palo-Alto.med.VA.gov Y1 - 1997/11// PY - 1997 DA - November 1997 SP - 2948 EP - 2954 VL - 17 IS - 11 SN - 1079-5642, 1079-5642 KW - Apolipoproteins B KW - 0 KW - CETP protein, human KW - Carrier Proteins KW - Cholesterol Ester Transfer Proteins KW - Cholesterol, Dietary KW - Glycoproteins KW - OSM protein, human KW - Osm protein, mouse KW - Peptides KW - RNA, Messenger KW - Receptors, LDL KW - Recombinant Proteins KW - Oncostatin M KW - 106956-32-5 KW - Cholesterol KW - 97C5T2UQ7J KW - Index Medicus KW - Animals KW - Recombinant Proteins -- pharmacology KW - Humans KW - Hypercholesterolemia -- etiology KW - Mice KW - Mice, Transgenic KW - Hypercholesterolemia -- metabolism KW - Genotype KW - Polymerase Chain Reaction KW - Cholesterol -- blood KW - Animal Feed KW - Mice, Inbred C57BL KW - Feedback KW - Hypercholesterolemia -- genetics KW - Male KW - Carrier Proteins -- genetics KW - Apolipoproteins B -- physiology KW - Liver -- metabolism KW - Peptides -- pharmacology KW - Receptors, LDL -- genetics KW - RNA, Messenger -- biosynthesis KW - Gene Expression Regulation -- genetics KW - Apolipoproteins B -- genetics KW - Cholesterol, Dietary -- toxicity KW - Carrier Proteins -- physiology KW - Gene Expression Regulation -- drug effects KW - Cholesterol, Dietary -- pharmacology KW - Receptors, LDL -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79487268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.atitle=Liver+LDL+receptor+mRNA+expression+is+decreased+in+human+ApoB%2FCETP+double+transgenic+mice+and+is+regulated+by+diet+as+well+as+the+cytokine+oncostatin+M.&rft.au=Liu%2C+J%3BZhang%2C+Y+L%3BSpence%2C+M+J%3BVestal%2C+R+E%3BWallace%2C+P+M%3BGrass%2C+D+S&rft.aulast=Liu&rft.aufirst=J&rft.date=1997-11-01&rft.volume=17&rft.issue=11&rft.spage=2948&rft.isbn=&rft.btitle=&rft.title=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.issn=10795642&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-01-22 N1 - Date created - 1998-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Erysipelothrix rhusiopathiae endocarditis: clinical features of an occupational disease. AN - 79439022; 9386061 AB - Erysipelothrix rhusiopathiae is becoming more commonly recognized in humans and has the potential for significant morbidity and mortality. In this article, we describe one patient's clinical symptoms after occupational exposure to E rhusiopathiae and its sequela. We discuss the natural history of the organism, three major categories of human disease, and treatment options. JF - Southern medical journal AU - Hill, D C AU - Ghassemian, J N AD - Fayetteville Veterans Administration Medical Center, NC 28301, USA. Y1 - 1997/11// PY - 1997 DA - November 1997 SP - 1147 EP - 1148 VL - 90 IS - 11 SN - 0038-4348, 0038-4348 KW - Abridged Index Medicus KW - Index Medicus KW - Occupational Exposure KW - Lung Diseases -- diagnosis KW - Animals KW - Humans KW - Lung Diseases -- microbiology KW - Middle Aged KW - Food-Processing Industry KW - Endocarditis, Bacterial -- diagnosis KW - Male KW - Swine KW - Occupational Diseases -- diagnosis KW - Erysipelothrix Infections -- physiopathology KW - Erysipelothrix Infections -- diagnosis KW - Meat-Packing Industry KW - Occupational Diseases -- physiopathology KW - Erysipelothrix Infections -- classification KW - Occupational Diseases -- therapy KW - Erysipelothrix Infections -- therapy KW - Occupational Diseases -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79439022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Erysipelothrix+rhusiopathiae+endocarditis%3A+clinical+features+of+an+occupational+disease.&rft.au=Hill%2C+D+C%3BGhassemian%2C+J+N&rft.aulast=Hill&rft.aufirst=D&rft.date=1997-11-01&rft.volume=90&rft.issue=11&rft.spage=1147&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-12-18 N1 - Date created - 1997-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prediction of myelotoxicity using semi-quantitative marrow image scores. AN - 79424570; 9374345 AB - Marrow radiation with resultant myelosuppression is usually dose-limiting in radioimmunotherapy (RIT). This study evaluated the relationship between a semiquantitative score of radiolabeled antibody marrow uptake obtained by imaging and subsequent decrease in peripheral blood cell counts in a patient population in whom marrow malignancy is common. Semiquantitative scores were assigned to lumbar marrow images of 18 patients acquired 0, 6, 24 and 48 hr after the first therapy dose of 131I-Lym-1. Scores were adjusted for injected dose (GBq) and body surface area (m2), and correlated with post-therapy blood counts. A well-defined scale, where 0 and 4 represented least to highest marrow uptake when compared to background, was used to assign marrow image scores. Injected doses of 131I-Lym-1 ranged from 1.1-8.2 GBq (29-222 mCi). Linear regression of summed marrow scores (0-24 hr after injection) versus decrease in cell counts produced correlation coefficients of 0.76, 0.44, 0.58 and 0.46 for platelets, granulocytes, white blood cells (WBC) and hematocrit, respectively. Scores for individual and other combinations of images obtained immediately up to 24 hr after injection were also predictive. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Lim, S AU - DeNardo, G L AU - DeNardo, D A AU - O'Donnell, R T AU - Yuan, A AU - DeNardo, S J AD - University of California Davis Medical Center; and Veterans Administration Northern California Health Care System, Sacramento 95816, USA. Y1 - 1997/11// PY - 1997 DA - November 1997 SP - 1749 EP - 1753 VL - 38 IS - 11 SN - 0161-5505, 0161-5505 KW - Iodine Radioisotopes KW - 0 KW - Index Medicus KW - Iodine Radioisotopes -- therapeutic use KW - Blood Cell Count -- radiation effects KW - Feasibility Studies KW - Radiotherapy Dosage KW - Humans KW - Linear Models KW - Iodine Radioisotopes -- adverse effects KW - Dose-Response Relationship, Radiation KW - Time Factors KW - Radionuclide Imaging KW - Radioimmunotherapy -- adverse effects KW - Bone Marrow -- diagnostic imaging KW - Bone Marrow -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79424570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Prediction+of+myelotoxicity+using+semi-quantitative+marrow+image+scores.&rft.au=Lim%2C+S%3BDeNardo%2C+G+L%3BDeNardo%2C+D+A%3BO%27Donnell%2C+R+T%3BYuan%2C+A%3BDeNardo%2C+S+J&rft.aulast=Lim&rft.aufirst=S&rft.date=1997-11-01&rft.volume=38&rft.issue=11&rft.spage=1749&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-12-11 N1 - Date created - 1997-12-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Nucl Med. 1997 Nov;38(11):1753-4 [9374346] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Posttraumatic Stress Disorder in a Community Group of Former Prisoners of War: A Normative Response to Severe Trauma AN - 61598083; 9815859 AB - Draws on psychological assessments of 262 US combat & prisoner of war veterans (WWII & the Korean War) who live in MN, WI, & ND, investigating the long-term nature & normative manifestations of posttraumatic stress disorder (PTSD). Diagnostic interviews & psychodiagnostic testing were used to determine subjects' psychopathology & assess influential factors. Results showed that 50+% suffered lifetime PTSD, with 29% meeting current PTSD criteria. Prisoners held by the Japanese represented the most traumatized group, with exceptionally high lifetime & current forms of the disorder. Regression analysis revealed that age at capture, severity of trauma, & postmilitary social support were moderately predictive of PTSD. It is concluded that PTSD is a persistent, normative, & primary consequence of exposure to severe trauma. 2 Tables, 48 References. Adapted from the source document. JF - The American Journal of Psychiatry AU - Engdahl, Brian AU - Dikel, Thomas N AU - Eberly, Raina AU - Blank, Arthur, Jr AD - Psychology Service Veterans Affairs Medical Center, One Veterans Dr Minneapolis MN 55417 engdahl.brian@minneapolis.va.gov Y1 - 1997/11// PY - 1997 DA - November 1997 SP - 1576 EP - 1581 VL - 154 IS - 11 SN - 0002-953X, 0002-953X KW - Veterans KW - North Dakota KW - Minnesota KW - Prisoners of War KW - United States of America KW - Wisconsin KW - Posttraumatic Stress Disorder KW - article KW - 0623: complex organization; military sociology KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61598083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Posttraumatic+Stress+Disorder+in+a+Community+Group+of+Former+Prisoners+of+War%3A+A+Normative+Response+to+Severe+Trauma&rft.au=Engdahl%2C+Brian%3BDikel%2C+Thomas+N%3BEberly%2C+Raina%3BBlank%2C+Arthur%2C+Jr&rft.aulast=Engdahl&rft.aufirst=Brian&rft.date=1997-11-01&rft.volume=154&rft.issue=11&rft.spage=1576&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Prisoners of War; United States of America; Veterans; Minnesota; Wisconsin; North Dakota ER - TY - JOUR T1 - Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor. AN - 79315053; 9323204 AB - Substance P is released in the spinal cord in response to painful stimuli, but its role in nociceptive signaling remains unclear. When a conjugate of substance P and the ribosome-inactivating protein saporin was infused into the spinal cord, it was internalized and cytotoxic to lamina I spinal cord neurons that express the substance P receptor. This treatment left responses to mild noxious stimuli unchanged, but markedly attenuated responses to highly noxious stimuli and mechanical and thermal hyperalgesia. Thus, lamina I spinal cord neurons that express the substance P receptor play a pivotal role in the transmission of highly noxious stimuli and the maintenance of hyperalgesia. JF - Science (New York, N.Y.) AU - Mantyh, P W AU - Rogers, S D AU - Honore, P AU - Allen, B J AU - Ghilardi, J R AU - Li, J AU - Daughters, R S AU - Lappi, D A AU - Wiley, R G AU - Simone, D A AD - Molecular Neurobiology Laboratory (151), Veterans Administration Medical Center, Minneapolis, MN 55417, USA. manty001@maroon.tc.umn.edu Y1 - 1997/10/10/ PY - 1997 DA - 1997 Oct 10 SP - 275 EP - 279 VL - 278 IS - 5336 SN - 0036-8075, 0036-8075 KW - Immunotoxins KW - 0 KW - Plant Proteins KW - Receptors, Neurokinin-1 KW - Ribosome Inactivating Proteins, Type 1 KW - Substance P KW - 33507-63-0 KW - N-Glycosyl Hydrolases KW - EC 3.2.2.- KW - saporin KW - EC 3.2.2.22 KW - Capsaicin KW - S07O44R1ZM KW - Index Medicus KW - Animals KW - Pain -- physiopathology KW - Plant Proteins -- pharmacology KW - Pain Measurement KW - Plant Proteins -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Cells, Cultured KW - Injections, Spinal KW - Cell Membrane -- metabolism KW - Fluorescent Antibody Technique KW - Signal Transduction KW - Pain Management KW - Neurons -- metabolism KW - Receptors, Neurokinin-1 -- biosynthesis KW - Spinal Cord -- metabolism KW - Substance P -- metabolism KW - Receptors, Neurokinin-1 -- metabolism KW - Substance P -- pharmacology KW - Hyperalgesia -- physiopathology KW - Hyperalgesia -- therapy KW - Neurons -- cytology KW - Spinal Cord -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79315053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Inhibition+of+hyperalgesia+by+ablation+of+lamina+I+spinal+neurons+expressing+the+substance+P+receptor.&rft.au=Mantyh%2C+P+W%3BRogers%2C+S+D%3BHonore%2C+P%3BAllen%2C+B+J%3BGhilardi%2C+J+R%3BLi%2C+J%3BDaughters%2C+R+S%3BLappi%2C+D+A%3BWiley%2C+R+G%3BSimone%2C+D+A&rft.aulast=Mantyh&rft.aufirst=P&rft.date=1997-10-10&rft.volume=278&rft.issue=5336&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-23 N1 - Date created - 1997-10-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Science. 1997 Oct 10;278(5336):239-40 [9340772] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improved resolution for PET volume imaging through three-dimensional iterative reconstruction. AN - 85271438; pmid-9379203 AB - It has been demonstrated that in two-dimensional iterative reconstruction, a resolution model can improve image resolution while controlling noise. With the lower noise levels of three-dimensional PET volume imaging, these iterative reconstruction advantages may be extended to three dimensions to further improve the reconstructed image resolution. METHODS: We have implemented three-dimensional versions of iterative filtered backprojection (IFBP) and the maximum likelihood by expectation maximization (ML-EM) reconstruction algorithms and applied them to three-dimensional PET volume datasets. The results were compared to images obtained using the standard three-dimensional reprojection reconstruction (3DRP) algorithm. RESULTS: For IFBP with 15 iterations and no regularization compared to 3DRP, both using a ramp filter, the transaxial resolution improved 52%, and the axial resolution improved 39%. With a strong regularization, the transaxial and axial resolution improvements were reduced to 6% and 5%, respectively. If a Hanning roll-off is applied to the ramp filter in the transaxial direction, the transaxial resolution for IFBP without regularization improved 35% compared to 3DRP; with regularization the improvement dropped to 19%. The axial resolution for IFBP and 3DRP was unaffected by this transaxial smoothing in the reconstruction filter. With the same Hanning roll-off, the noise for IFBP without regularization increased by a factor of 6 compared to 3DRP; with regularization the noise was increased only by a factor of 3. Compared to IFBP, the three-dimensional ML-EM reconstruction produced similar resolution improvements with a much smaller increase in noise and slower convergence. Resolution improvements from both IFBP and ML-EM reconstructions are visually apparent in three-dimensional FDG brain images and result in increased activation signals in a three-dimensional [15O]water functional activation study. CONCLUSION: Our results demonstrate that resolution improvement is possible for IFBP and ML-EM compared to 3DRP with or without noise increase. JF - Journal of Nuclear Medicine AU - Liow, J S AU - Strother, S C AU - Rehm, K AU - Rottenberg, D A AD - Veterans Administration Medical Center, Minneapolis, Minnesota 55147, USA. PY - 1997 SP - 1623 EP - 1631 VL - 38 IS - 10 SN - 0161-5505, 0161-5505 KW - Comparative Study KW - Support, U.S. Gov't, P.H.S. KW - Radiopharmaceuticals KW - Oxygen Radioisotopes KW - Fludeoxyglucose F 18 KW - Human KW - Fluorine Radioisotopes KW - Brain KW - Tomography, Emission-Computed KW - Time Factors KW - Image Processing, Computer-Assisted KW - Water KW - Algorithms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85271438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nuclear+Medicine&rft.atitle=Improved+resolution+for+PET+volume+imaging+through+three-dimensional+iterative+reconstruction.&rft.au=Liow%2C+J+S%3BStrother%2C+S+C%3BRehm%2C+K%3BRottenberg%2C+D+A&rft.aulast=Liow&rft.aufirst=J&rft.date=1997-10-01&rft.volume=38&rft.issue=10&rft.spage=1623&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Attentional systems and the allocation of cerebral resources in reading and grammatical tasks. AN - 85257018; pmid-9394230 AB - To evaluate the possible role of attentional centers as modulators of neural networks that mediate visual tasks involving reading and grammatical manipulations of verbs, we measured cerebral blood flow (CBF) using positron emission tomography (PET), and reaction times as subjects read verbs, "nonce verbs" such as jelt or brep, and formed past tenses of regular, irregular and nonce verbs after viewing their stems. Statistical parametric maps (SPMs) showed significant activation of the pulvinar in the read verb irregular, and generate nonce past tense tasks, compared to rest. This was confirmed by a post hoc ANOVA of CBF values from a discrete locus in the pulvinar (p = .0000417). Functional links between the pulvinar and other brain regions were shown by high correlations of CBF in the pulvinar with CBF in brain regions known to have anatomical connections to the pulvinar, particularly those mediating vision. There was also a significant relationship between task-specific reaction times and rest minus task CBF differences in a multiple regression analysis that included CBF values from the pulvinar, superior colliculus plus reticular formation, and the anterior cingulate, known attentional centers (p = .021, r2 = 0.99). Regression analyses relating reaction time to the amount of brain activated (pixels in the SPMs) and the degree of activation of the pixels (mean Z score) yielded p values of .078 and .074, respectively. Our data provide direct experimental evidence to support the hypothesis that attentional centers are activated in proportion to the complexity of visually mediated language tasks and that the centers that mediate attention modulate the activity of task-specific neural networks. JF - The International Journal of Neuroscience AU - Lockwood, A H AU - Murphy, B W AU - Khalak, H AD - Center for Positron Emission Tomography, Mabie Laboratory for Behavioral Neuroscience, Western New York Veterans Administration Healthcare System, Buffalo 14215, USA. PY - 1997 SP - 241 EP - 252 VL - 91 IS - 3-4 SN - 0020-7454, 0020-7454 KW - Human KW - Adult KW - Brain KW - Support, Non-U.S. Gov't KW - Support, U.S. Gov't, Non-P.H.S. KW - Tomography, Emission-Computed KW - Cerebrovascular Circulation KW - Attention KW - Male KW - Reaction Time KW - Reading KW - Language UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85257018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+Journal+of+Neuroscience&rft.atitle=Attentional+systems+and+the+allocation+of+cerebral+resources+in+reading+and+grammatical+tasks.&rft.au=Lockwood%2C+A+H%3BMurphy%2C+B+W%3BKhalak%2C+H&rft.aulast=Lockwood&rft.aufirst=A&rft.date=1997-10-01&rft.volume=91&rft.issue=3-4&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=The+International+Journal+of+Neuroscience&rft.issn=00207454&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Eating changes in mild-stage Alzheimer's disease: a pilot study. AN - 85233430; pmid-9294942 AB - Eating impairment is well documented in the late stage of Alzheimer's disease (AD) but when these eating changes actually begin in the disease process is not known. Eating was defined as consisting of two components, self-feeding and swallowing. Self-feeding and swallowing of healthy elderly were compared with a group of individuals with mild AD. AD subjects received significantly more partner-initiated cues or direct assistance than controls. In addition, subject-initiated cued behaviors occurred more frequently in the AD group. AD subjects demonstrated significantly prolonged swallow durations for the oral transit duration (cookie), pharyngeal response duration (liquid), and total swallow duration (liquid). This pilot study suggests that self-feeding and swallowing changes may occur early in the course of AD. JF - Dysphagia AU - Priefer, B A AU - Robbins, J AD - Geriatric Research, Education, and Clinical Center, Wm. S. Middleton Memorial Veterans Administration Hospital Madison, Wisconsin 53705, USA. PY - 1997 SP - 212 EP - 221 VL - 12 IS - 4 SN - 0179-051X, 0179-051X KW - Deglutition Disorders KW - Comparative Study KW - Human KW - Alzheimer Disease KW - Aged KW - Support, Non-U.S. Gov't KW - Pilot Projects KW - Feeding Behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85233430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dysphagia&rft.atitle=Eating+changes+in+mild-stage+Alzheimer%27s+disease%3A+a+pilot+study.&rft.au=Priefer%2C+B+A%3BRobbins%2C+J&rft.aulast=Priefer&rft.aufirst=B&rft.date=1997-10-01&rft.volume=12&rft.issue=4&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=Dysphagia&rft.issn=0179051X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Selective effects on prefrontal cortex serotonin by dopamine D3 receptor agonism: interaction with low-dose haloperidol. AN - 79510329; 9421827 AB - 1. Negative symptoms of schizophrenia are characterized by amotivation, anhedonia and anergia. These aspects of the symptom profile can be modeled by D3 agonism in animal behavioral models. 2. Serotonergic systems have been implicated in pathophysiologic substrates for this disorder; most notably, in deficit state schizophrenia, as newer 'atypical' neuroleptics which are especially efficacious for treating this syndrome antagonize central 5-HT2 receptors. 3. FC regions may also be important in chronic negative symptoms, as hypofrontality has been associated with these schizophrenic features. 4. The author examined effects of a behaviorally-active dose of the D3 agonist, 7OH, on 5-HT metabolism in FC, and the ability of a low-dose neuroleptic treatment to antagonize this biochemical effect. 5. Acute administration of 7OH induced a selective decrease of 5-HT turnover in the FC without affecting metabolism of this transmitter in more subcortical DA regions. 6. Hal, which has previously been demonstrated to antagonize electrophysiologic, biochemical and behavioral effects of 7OH, was without effect on agonist-induced decreases in 5-HT turnover. 7. The biochemical association between D3 agonism and reductions of FC 5-HT may be significant for pathophysiologic mechanisms of negative symptoms, and antagonism of this effect may differ for neuroleptics with varying efficacy in alleviating these symptoms. JF - Progress in neuro-psychopharmacology & biological psychiatry AU - Lynch, M R AD - Research Service, Veterans Administration Medical Center, Syracuse, New York, USA. Y1 - 1997/10// PY - 1997 DA - October 1997 SP - 1141 EP - 1153 VL - 21 IS - 7 SN - 0278-5846, 0278-5846 KW - Antipsychotic Agents KW - 0 KW - Dopamine Agonists KW - Serotonin KW - 333DO1RDJY KW - Haloperidol KW - J6292F8L3D KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Prefrontal Cortex -- physiology KW - Prefrontal Cortex -- drug effects KW - Male KW - Dopamine Agonists -- pharmacology KW - Antipsychotic Agents -- pharmacology KW - Haloperidol -- pharmacology KW - Schizophrenia -- drug therapy KW - Dopamine Agonists -- administration & dosage KW - Serotonin -- metabolism KW - Schizophrenia -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79510329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+neuro-psychopharmacology+%26+biological+psychiatry&rft.atitle=Selective+effects+on+prefrontal+cortex+serotonin+by+dopamine+D3+receptor+agonism%3A+interaction+with+low-dose+haloperidol.&rft.au=Lynch%2C+M+R&rft.aulast=Lynch&rft.aufirst=M&rft.date=1997-10-01&rft.volume=21&rft.issue=7&rft.spage=1141&rft.isbn=&rft.btitle=&rft.title=Progress+in+neuro-psychopharmacology+%26+biological+psychiatry&rft.issn=02785846&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-01-28 N1 - Date created - 1998-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acute effects of ski waxing on pulmonary function. AN - 79356259; 9346171 AB - The objective of this study was to determine whether pulmonary function is acutely affected by moderate exposure to ski waxing. Ten healthy nonsmoking young adult volunteers were exposed to 45 min of ski waxing in a small unventilated room. The exposure occurred in pairs with one individual performing the waxing while the other overlooked the waxing process. During the period of waxing, two pairs of cross-country skis were waxed with a paraffin wax and then scraped and brushed, and two pairs of cross-country skis were waxed with a fluorinated wax and then brushed. Spirometry and single-breath carbon monoxide lung diffusion capacity (DLCO) were measured immediately before and after exposure to ski waxing, and again 5-6 h after waxing. A subset of five subjects repeated the measurements on a separate day without receiving exposure to ski waxing. Data were analyzed with repeated measures ANOVA. Exposure to ski waxing induced no significant changes in spirometry and DLCO measurements. We conclude that moderate exposure to ski waxing has no significant acute effect on lung function. JF - Medicine and science in sports and exercise AU - Hoffman, M D AU - Clifford, P S AU - Varkey, B AD - Department of Physical Medicine and Rehabilitation, Medical College of Wisconsin and VA Medical Center, Milwaukee 53295, USA. hoffman.martin_d@milwaukee.va.gov Y1 - 1997/10// PY - 1997 DA - October 1997 SP - 1379 EP - 1382 VL - 29 IS - 10 SN - 0195-9131, 0195-9131 KW - Fluorocarbon Polymers KW - 0 KW - Hydrocarbons, Fluorinated KW - Waxes KW - Paraffin KW - 8002-74-2 KW - Index Medicus KW - Space life sciences KW - Fluorocarbon Polymers -- adverse effects KW - Analysis of Variance KW - Spirometry KW - Humans KW - Adult KW - Paraffin -- adverse effects KW - Lung Volume Measurements KW - Hydrocarbons, Fluorinated -- adverse effects KW - Pulmonary Diffusing Capacity KW - Waxes -- adverse effects KW - Skiing KW - Sports Equipment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79356259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicine+and+science+in+sports+and+exercise&rft.atitle=Acute+effects+of+ski+waxing+on+pulmonary+function.&rft.au=Hoffman%2C+M+D%3BClifford%2C+P+S%3BVarkey%2C+B&rft.aulast=Hoffman&rft.aufirst=M&rft.date=1997-10-01&rft.volume=29&rft.issue=10&rft.spage=1379&rft.isbn=&rft.btitle=&rft.title=Medicine+and+science+in+sports+and+exercise&rft.issn=01959131&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-11-25 N1 - Date created - 1997-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - HIV and occupational risk. Evolving ways to protect healthcare workers. AN - 79343598; 9336603 AB - HIV has significantly altered the face of healthcare and the lives of virtually everyone in our communities. The risk of transmission, particularly through needlestick injuries, continues to be a major concern for all of us working in healthcare services. Dr Thurn reviews new information about modes of HIV transmission, ways to reduce risks, and guidelines for managing exposures, should they occur. JF - Postgraduate medicine AU - Thurn, J R AD - Infectious Disease Section, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA. Thurn.Joseph_R(STF)@Minneapolis.VA.gov Y1 - 1997/10// PY - 1997 DA - October 1997 SP - 155 EP - 161 VL - 102 IS - 4 SN - 0032-5481, 0032-5481 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - United States KW - Risk Factors KW - Needlestick Injuries -- prevention & control KW - Humans KW - Health Personnel KW - Infection Control KW - HIV Infections -- transmission KW - Occupational Diseases -- prevention & control KW - HIV Infections -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79343598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+medicine&rft.atitle=HIV+and+occupational+risk.+Evolving+ways+to+protect+healthcare+workers.&rft.au=Thurn%2C+J+R&rft.aulast=Thurn&rft.aufirst=J&rft.date=1997-10-01&rft.volume=102&rft.issue=4&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Postgraduate+medicine&rft.issn=00325481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-11-05 N1 - Date created - 1997-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of an ion-trap and a quadrupole mass spectrometer using diazepam as a model compound. AN - 79324217; 9323524 AB - Recent innovations in mass spectrometry (MS) have led to the development of instruments with increased capabilities, smaller footprints, and relatively low cost. The traditional MS in most toxicology laboratories is a quadrupole system equipped with electron impact ionization. Recently, an ion trap with electron impact, positive chemical ionization, negative chemical ionization, and tandem MS capabilities was introduced by Finnigan MAT. This paper compares the sensitivity and precision of ion-ratio measurements between a Finnigan GCQ ion-trap mass spectrometer (ITMS) and a Hewlett Packard quadrupole mass spectrometer (QMS) using electron impact ionization with diazepam as the model compound. Additionally, the sensitivity and precision of ion ratio measurements are evaluated for the ITMS using positive chemical ionization, negative chemical ionization and tandem MS modes of analysis. In the full scan mode (m/z 50-650, 1 Hz), the ITMS had an average signal-to-noise ratio (S/N) of 1400 for a 2-ng injection of diazepam (10 injections per day for 5 days), within-run ion ratio precision had coefficients of variation from 5 to 11%. Using similar full scan conditions, a 10-ng injection of diazepam on the QMS had an average S/N ratio of 160, and precision of ion ratio measurements varied from 5 to 13%. In the selected ion mode (SIM) of analysis (three ions, 2 Hz), the ITMS had an average S/N of 14,000 for a 2-ng injection and ion-ratio precision ranging from 6 to 15%. Using similar SIM conditions, a 2-ng injection in the QMS had an average S/N of 3000 with ion ratio standard deviations of 0.67 to 2.9%. Overall, the ITMS provided at greater S/N, equivalent precision in full scan, but was 5- to 10-fold less precise in measuring ion ratios in the SIM mode as compared with the QMS. JF - Journal of analytical toxicology AU - Fitzgerald, R L AU - O'Neal, C L AU - Hart, B J AU - Poklis, A AU - Herold, D A AD - Veterans Administration Medical Center San Diego, California 92161, USA. rlfitzgerald@vapop.ucsd.edu Y1 - 1997/10// PY - 1997 DA - October 1997 SP - 445 EP - 450 VL - 21 IS - 6 SN - 0146-4760, 0146-4760 KW - Anti-Anxiety Agents KW - 0 KW - Cross-Linking Reagents KW - Diazepam KW - Q3JTX2Q7TU KW - Index Medicus KW - Forensic Medicine KW - Humans KW - Mass Spectrometry -- instrumentation KW - Anti-Anxiety Agents -- analysis KW - Mass Spectrometry -- methods KW - Diazepam -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79324217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Comparison+of+an+ion-trap+and+a+quadrupole+mass+spectrometer+using+diazepam+as+a+model+compound.&rft.au=Fitzgerald%2C+R+L%3BO%27Neal%2C+C+L%3BHart%2C+B+J%3BPoklis%2C+A%3BHerold%2C+D+A&rft.aulast=Fitzgerald&rft.aufirst=R&rft.date=1997-10-01&rft.volume=21&rft.issue=6&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=01464760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-11-19 N1 - Date created - 1997-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of inhibitors of signal transduction pathways on transforming growth factor beta1 and osteogenic protein-1-induced insulinlike growth factor binding protein-3 expression in human bone cells. AN - 79322184; 9326446 AB - Signal transduction initiated by TGFbeta1 and OP-1 was studied in MG63 human osteosarcoma cells and in normal human bone cells (HBCs) in the presence of inhibitors of signal transduction events, using insulinlike growth factor binding protein-3 (IGFBP-3) production as an end point. Treatment of serum-free MG63 cells and normal HBCs with TGFbeta1 increased IGFBP-3 protein level several fold in the conditioned medium. This effect of TGFbeta1 was mediated by increased de novo synthesis because mRNA level increased to the same extent as protein level and TGFbeta1 treatment had very little effect on IGFBP-3 protease activity. The stimulatory effect of TGFbeta1 on IGFBP-3 production was inhibited in a dose-dependent manner by pretreatment with staurosporine, a protein kinase C inhibitor, or with vanadate, a phosphotyrosyl protein phosphatase inhibitor in both MG63 cells and normal HBCs. In addition, pretreatment with okadoic acid, an inhibitor of serine/threonine protein phosphatase, counteracted TGFbeta1 induction of IGFBP-3 production. Interestingly, pretreatment of MG63 cells or HBCs with staurosporine, vanadate, or okadoic acid augmented OP-1 stimulation of IGFBP3 production. Staurosporine- or vanadate-induced changes in IGFBP-3 protein levels in the presence of TGFbeta1 and OP-1 were associated with corresponding changes in IGFBP-3 mRNA levels in MG63 cells. These findings are consistent with the hypothesis that TGFbeta1 and OP-1 increase IGFBP-3 expression via distinct intracellular signal transduction pathways. JF - Journal of cellular physiology AU - Srinivasan, N AU - Baylink, D J AU - Sampath, K AU - Mohan, S AD - Department of Medicine, Loma Linda University, The Mineral Metabolism, Jerry L. Pettis Veterans Administration Medical Center, California 92357, USA. Y1 - 1997/10// PY - 1997 DA - October 1997 SP - 28 EP - 35 VL - 173 IS - 1 SN - 0021-9541, 0021-9541 KW - BMP7 protein, human KW - 0 KW - Bone Morphogenetic Protein 7 KW - Bone Morphogenetic Proteins KW - Culture Media, Conditioned KW - Insulin-Like Growth Factor Binding Protein 3 KW - Isoflavones KW - RNA, Messenger KW - Transforming Growth Factor beta KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Vanadates KW - 3WHH0066W5 KW - Genistein KW - DH2M523P0H KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - Protein Tyrosine Phosphatases KW - EC 3.1.3.48 KW - Staurosporine KW - H88EPA0A3N KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Phosphoprotein Phosphatases -- antagonists & inhibitors KW - Isoflavones -- pharmacology KW - Vanadates -- pharmacology KW - Humans KW - Protein-Serine-Threonine Kinases -- antagonists & inhibitors KW - Gene Expression Regulation -- genetics KW - Protein-Tyrosine Kinases -- antagonists & inhibitors KW - Staurosporine -- pharmacology KW - Protein Kinase C -- antagonists & inhibitors KW - Tumor Cells, Cultured KW - RNA, Messenger -- metabolism KW - Cells, Cultured KW - Okadaic Acid -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Protein Tyrosine Phosphatases -- antagonists & inhibitors KW - Osteoblasts -- metabolism KW - Osteoblasts -- drug effects KW - Insulin-Like Growth Factor Binding Protein 3 -- genetics KW - Transforming Growth Factor beta -- pharmacology KW - Insulin-Like Growth Factor Binding Protein 3 -- biosynthesis KW - Bone Morphogenetic Proteins -- pharmacology KW - Signal Transduction -- drug effects KW - Bone and Bones -- metabolism KW - Bone and Bones -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79322184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=Effects+of+inhibitors+of+signal+transduction+pathways+on+transforming+growth+factor+beta1+and+osteogenic+protein-1-induced+insulinlike+growth+factor+binding+protein-3+expression+in+human+bone+cells.&rft.au=Srinivasan%2C+N%3BBaylink%2C+D+J%3BSampath%2C+K%3BMohan%2C+S&rft.aulast=Srinivasan&rft.aufirst=N&rft.date=1997-10-01&rft.volume=173&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=00219541&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-23 N1 - Date created - 1997-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Homeless Mentally Ill Veterans: Race, Service Use, and Treatment Outcomes AN - 61553854; 199802894 AB - Compares service use & treatment outcomes for 145 black & 236 white homeless veterans with mental disorders, drawing on 1987/88 interview data collected by a veteran's program at 9 US sites; follow-up data were collected approximately 7-9 months following program recruitment. Analyses showed few differences between outcomes by racial group. A greater improvement in psychiatric symptoms & alcohol problems among white than black veterans did not hold true when black veterans had participated in the residential treatment component of the program. Implications of the findings for the successful treatment of homeless black veterans are discussed. 4 Tables, 21 References. Adapted from the source document. JF - American Journal of Orthopsychiatry AU - Rosenheck, Robert AU - Leda, Catherine AU - Frisman, Linda AU - Gallup, Peggy AD - Northeast Program Evaluation Center Veterans Administration Medical Center, 950 Campbell Ave West Haven CT 06516 Y1 - 1997/10// PY - 1997 DA - October 1997 SP - 632 EP - 638 VL - 67 IS - 4 SN - 0002-9432, 0002-9432 KW - Veterans KW - Treatment Outcomes KW - Black White Differences KW - Treatment Programs KW - Residential Institutions KW - Mental Illness KW - Health Care Utilization KW - Homelessness KW - article KW - 6141: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61553854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Orthopsychiatry&rft.atitle=Homeless+Mentally+Ill+Veterans%3A+Race%2C+Service+Use%2C+and+Treatment+Outcomes&rft.au=Rosenheck%2C+Robert%3BLeda%2C+Catherine%3BFrisman%2C+Linda%3BGallup%2C+Peggy&rft.aulast=Rosenheck&rft.aufirst=Robert&rft.date=1997-10-01&rft.volume=67&rft.issue=4&rft.spage=632&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Orthopsychiatry&rft.issn=00029432&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Homelessness; Mental Illness; Veterans; Treatment Outcomes; Health Care Utilization; Black White Differences; Treatment Programs; Residential Institutions ER - TY - JOUR T1 - Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice. AN - 79279075; 9294099 AB - The purpose of this study was to determine the relative importance of the metabolic effects of insulin for diabetes prevention by administering insulin or an inactive insulin analog by daily subcutaneous injections to prediabetic mice. A recombinant monomeric human insulin analog, which does not bind to the insulin receptor as a consequence of an alteration of a single amino acid at position 25 of the B chain, was shown to be equally effective at diabetes prevention as was intact insulin. In contrast to native insulin, the insulin analog did not cause hypoglycemia after subcutaneous injection. The insulin analog, however, protected young adult mice from diabetes, even when it was initiated after the onset of extensive lymphocytic infiltration of the islets. Thus, preventative therapy by daily subcutaneous injections of insulin does not require the hypoglycemic response, or binding to the insulin receptor to prevent the onset of type I diabetes. JF - The Journal of clinical investigation AU - Karounos, D G AU - Bryson, J S AU - Cohen, D A AD - Department of Internal Medicine, Veterans Administration Medical Center and University of Kentucky College of Medicine, Lexington, Kentucky 40536-0084, USA. dkaroun@pop.uky.edu Y1 - 1997/09/15/ PY - 1997 DA - 1997 Sep 15 SP - 1344 EP - 1348 VL - 100 IS - 6 SN - 0021-9738, 0021-9738 KW - Insulin KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Pancreas -- pathology KW - Animals KW - Mice, Inbred NOD KW - Injections, Subcutaneous KW - Autoimmunity -- drug effects KW - Mice KW - Lymphocytes -- physiology KW - Hypoglycemia -- chemically induced KW - Time Factors KW - Female KW - Diabetes Mellitus, Type 1 -- prevention & control KW - Prediabetic State -- prevention & control KW - Insulin -- analogs & derivatives KW - Insulin -- administration & dosage KW - Diabetes Mellitus, Type 1 -- pathology KW - Insulin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79279075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Metabolically+inactive+insulin+analog+prevents+type+I+diabetes+in+prediabetic+NOD+mice.&rft.au=Karounos%2C+D+G%3BBryson%2C+J+S%3BCohen%2C+D+A&rft.aulast=Karounos&rft.aufirst=D&rft.date=1997-09-15&rft.volume=100&rft.issue=6&rft.spage=1344&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-12-08 N1 - Date created - 1997-12-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Diabetes Care. 1990 Sep;13(9):923-54 [2226110] Diabetes. 1990 Sep;39(9):1085-90 [2200729] Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10252-6 [1946445] Diabet Med. 1991 Nov;8(9):839-47 [1663018] Diabetes. 1994 Mar;43(3):505-9 [8314025] J Clin Invest. 1995 Feb;95(2):628-34 [7860747] J Autoimmun. 1994 Dec;7(6):833-43 [7888039] Curr Opin Immunol. 1994 Dec;6(6):900-6 [7710714] Eur J Immunol. 1995 Apr;25(4):1056-62 [7537670] Diabetes. 1995 Jul;44(7):859-62 [7789655] Diabetes. 1995 Aug;44(8):906-10 [7621995] Am J Pathol. 1995 Nov;147(5):1193-9 [7485382] Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):956-60 [8570667] J Immunol. 1983 Aug;131(2):701-5 [6190938] Diabetes. 1983 Aug;32(8):712-7 [6347768] J Immunol. 1987 Dec 1;139(11):3622-9 [2445817] Diabetes. 1988 Mar;37(3):351-8 [3286334] Diabetes. 1988 Nov;37(11):1587-90 [3053305] Diabetes. 1989 Oct;38(10):1326-8 [2676661] Diabet Med. 1990 May;7(4):327-30 [2140085] Diabetes. 1990 Jun;39(6):697-701 [2189761] Diabetes. 1990 Aug;39(8):933-7 [2197139] Diabetes. 1991 Nov;40(11):1488-95 [1657669] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular basis for the interaction of [Nle4,D-Phe7]melanocyte stimulating hormone with the human melanocortin-1 receptor. AN - 79275891; 9287296 AB - The melanocortin-1 receptor (MC1R) is a seven-transmembrane (TM) G-protein-coupled receptor whose natural ligands are the melanocortin peptides, adrenocorticotropic hormone, and alpha-, beta-, and gamma- melanocyte stimulating hormone (MSH). To test a previously constructed three-dimensional model of the molecular interaction between the long-acting, superpotent alpha-MSH analog [Nle4,D-Phe7]MSH (NDP-MSH) and the human MC1R we examined the effects of site-directed receptor mutagenesis on the binding affinity and potency of NDP-MSH. In addition, we also examined the effects of these same mutations on the binding affinity and potency of the structurally related agonists alpha-MSH, gamma-MSH, and Ac-Nle4-cyclic-[Asp5,His6,D-Phe7,Arg8,Trp9,Lys10]NH2 (MT-II). Mutagenesis of acidic receptor residues Glu94 in TM2 and Asp117 or Asp121 in TM3 significantly altered the binding affinity and potency of all four agonists suggesting that these receptor residues are important to the ligand-receptor interactions of all. A disproportionate change in agonist potency versus affinity observed with simultaneous mutation of these acidic residues (mutant constructs D117A/D121A or E94A/D117A/D121A) or introduction of a single positive charge (mutant construct D121K) also implicates these residues in receptor activation. In addition, results from the individual mutation of aromatic receptor residues Phe175, Phe196, and Phe257, and simultaneous mutation of multiple TM4, -5, and -6 tyrosine and phenylalanine residues suggests that aromatic-aromatic ligand-receptor interactions also participate in binding these melanocortins to the MC1R. These experiments appear to have identified some of the critical receptor residues involved in the ligand-receptor interactions between these melanocortins and the hMC1R. JF - The Journal of biological chemistry AU - Yang, Y k AU - Dickinson, C AU - Haskell-Luevano, C AU - Gantz, I AD - Department of Internal Medicine, University of Michigan Medical School and Veterans Administration Medical Center, Ann Arbor, Michigan 48109-0682, USA. Y1 - 1997/09/12/ PY - 1997 DA - 1997 Sep 12 SP - 23000 EP - 23010 VL - 272 IS - 37 SN - 0021-9258, 0021-9258 KW - Ligands KW - 0 KW - Receptors, Corticotropin KW - Receptors, Melanocortin KW - alpha-MSH KW - 581-05-5 KW - MSH, 4-Nle-7-Phe-alpha- KW - 75921-69-6 KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Models, Molecular KW - Humans KW - DNA Mutational Analysis KW - Cyclic AMP -- analysis KW - Binding Sites -- genetics KW - Structure-Activity Relationship KW - Receptors, Corticotropin -- genetics KW - alpha-MSH -- metabolism KW - alpha-MSH -- analogs & derivatives KW - Receptors, Corticotropin -- metabolism KW - Receptors, Corticotropin -- agonists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79275891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Molecular+basis+for+the+interaction+of+%5BNle4%2CD-Phe7%5Dmelanocyte+stimulating+hormone+with+the+human+melanocortin-1+receptor.&rft.au=Yang%2C+Y+k%3BDickinson%2C+C%3BHaskell-Luevano%2C+C%3BGantz%2C+I&rft.aulast=Yang&rft.aufirst=Y&rft.date=1997-09-12&rft.volume=272&rft.issue=37&rft.spage=23000&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-01 N1 - Date created - 1997-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mode of chemotherapy does not affect complications with an implantable venous access device. AN - 79300224; 9307199 AB - Few reports have been made regarding the long term safety of implantable venous access devices used for the delivery of chemotherapeutic agents. The authors' goals were to determine the frequency of complications in patients receiving chemotherapy with these devices; to determine whether complications were associated with the mode of chemotherapy delivery (push/bolus or infusional regimens); and to evaluate the influence of other risk factors, including home-based versus hospital-based administration. A total of 152 oncology patients at the John L. McClellan Memorial Veterans Administration Medical Center in Little Rock, Arkansas (ages 26-81 years; mean age, 62 years), who underwent surgical placement of an Infus-a-Port (Strato, Inc., Beverly, MA) between May 1, 1992 and May 31, 1994, were evaluated retrospectively for postplacement device complications, such as infection, thrombosis, and mechanical failure. Twenty-seven patients experienced 1 complication each: 17 episodes of device-related sepsis, cellulitis, or fever of unknown origin; 8 episodes of thrombosis or catheter occlusion; 1 episode of drug extravasation; and 1 mechanical failure. Patient age, frequency of port accession, mode of chemotherapy delivery, tumor type, and neutropenia were evaluated as risk factors, but none was statistically significant. Complications were more frequent during the first 90 days after implantation, but they continued to occur throughout the observation period. Complications attributable to an implantable venous access device were infrequent in this patient population. No differences in complications for patients receiving home-based versus hospital-based chemotherapy administration were noted, opening the possibility of significant time and cost savings with home treatment. JF - Cancer AU - Brown, D F AU - Muirhead, M J AU - Travis, P M AU - Vire, S R AU - Weller, J AU - Hauer-Jensen, M AD - Department of Pharmacy, John L. McClellan Memorial Veterans Administration Medical Center, Little Rock, Arkansas 72205, USA. Y1 - 1997/09/01/ PY - 1997 DA - 1997 Sep 01 SP - 966 EP - 972 VL - 80 IS - 5 SN - 0008-543X, 0008-543X KW - Antineoplastic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Equipment Contamination KW - Thrombophlebitis -- etiology KW - Neutropenia -- etiology KW - Humans KW - Retrospective Studies KW - Aged KW - Extravasation of Diagnostic and Therapeutic Materials -- etiology KW - Equipment Failure KW - Home Infusion Therapy -- adverse effects KW - Sepsis -- etiology KW - Aged, 80 and over KW - Oncology Service, Hospital KW - Adult KW - Fever of Unknown Origin -- etiology KW - Sepsis -- microbiology KW - Middle Aged KW - Statistics as Topic KW - Cellulitis -- etiology KW - Female KW - Male KW - Survival Analysis KW - Catheterization, Central Venous -- adverse effects KW - Antineoplastic Agents -- administration & dosage KW - Infusion Pumps, Implantable -- adverse effects KW - Catheterization, Central Venous -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79300224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Mode+of+chemotherapy+does+not+affect+complications+with+an+implantable+venous+access+device.&rft.au=Brown%2C+D+F%3BMuirhead%2C+M+J%3BTravis%2C+P+M%3BVire%2C+S+R%3BWeller%2C+J%3BHauer-Jensen%2C+M&rft.aulast=Brown&rft.aufirst=D&rft.date=1997-09-01&rft.volume=80&rft.issue=5&rft.spage=966&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-08 N1 - Date created - 1997-10-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Construction and characterization of an OHIO-1 beta-lactamase bearing Met69Ile and Gly238Ser mutations. AN - 79291088; 9303389 AB - Amino acid changes that influence activity and resistance to beta-lactams and beta-lactamase inhibitors were explored by constructing the Gly238Ser and Met69Ile-Gly238Ser mutants of the OHIO-1 beta-lactamase, a class A enzyme of the SHV family. The Km values of cefotaxime and ceftazidime for OHIO-1 and Met69Ile beta-lactamases were > or = 500 microM. The Km of cefotaxime for the Gly238Ser beta-lactamase was 26 microM, and that of ceftazidime was 105 microM. The Km of cefotaxime for the Met69Ile-Gly238Ser beta-lactamase was 292 microM, and that of ceftazidime was 392 microM. For the beta-lactamase inhibitors clavulanate and sulbactam, the apparent Ki values for the Met69Ile-Gly238Ser enzyme were 0.03 and 0.15 microM, respectively. Relative Vmax values indicate that the Met69Ile-Gly238Ser mutant of the OHIO-1 beta-lactamase possesses cephalosporinase activity similar to that of the Gly238Ser mutant but diminished penicillinase activity. In an Escherichia coli DH5alpha strain that possesses a Met69Ile beta-lactamase of the OHIO-1 family, the added Gly238Ser mutation resulted in a phenotype with qualities that confer resistance to expanded-spectrum cephalosporins and, to a lesser extent, beta-lactamase inhibitors. JF - Antimicrobial agents and chemotherapy AU - Bonomo, R A AU - Knox, J R AU - Rudin, S D AU - Shlaes, D M AD - Research Service, U.S. Department of Veterans Affairs Medical Center, and Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA. rab14@po.cwru.edu Y1 - 1997/09// PY - 1997 DA - September 1997 SP - 1940 EP - 1943 VL - 41 IS - 9 SN - 0066-4804, 0066-4804 KW - Enzyme Inhibitors KW - 0 KW - Isoleucine KW - 04Y7590D77 KW - Serine KW - 452VLY9402 KW - Methionine KW - AE28F7PNPL KW - beta-Lactamases KW - EC 3.5.2.6 KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Phenotype KW - Mutagenesis, Site-Directed KW - Isoleucine -- genetics KW - Methionine -- genetics KW - Glycine -- genetics KW - beta-Lactam Resistance KW - Kinetics KW - Glycine -- metabolism KW - Methionine -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Cephalosporin Resistance KW - Isoleucine -- metabolism KW - Serine -- metabolism KW - Serine -- genetics KW - beta-Lactamases -- biosynthesis KW - Mutation KW - beta-Lactamases -- metabolism KW - beta-Lactamases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79291088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Construction+and+characterization+of+an+OHIO-1+beta-lactamase+bearing+Met69Ile+and+Gly238Ser+mutations.&rft.au=Bonomo%2C+R+A%3BKnox%2C+J+R%3BRudin%2C+S+D%3BShlaes%2C+D+M&rft.aulast=Bonomo&rft.aufirst=R&rft.date=1997-09-01&rft.volume=41&rft.issue=9&rft.spage=1940&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-31 N1 - Date created - 1997-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antimicrob Agents Chemother. 1997 Jun;41(6):1322-5 [9174192] Antimicrob Agents Chemother. 1995 Dec;39(12):2593-601 [8592985] Biotechniques. 1989 Mar;7(3):282-9 [2698649] Antimicrob Agents Chemother. 1990 Aug;34(8):1570-6 [2121093] Mol Microbiol. 1990 Oct;4(10):1615-20 [2077352] Biochem J. 1991 May 15;276 ( Pt 1):269-70 [2039479] Biochemistry. 1992 Apr 21;31(15):3847-52 [1567841] FEMS Microbiol Lett. 1992 Mar 1;70(2):113-7 [1316862] Biochem J. 1992 Jun 1;284 ( Pt 2):411-5 [1599426] FEMS Microbiol Lett. 1992 Apr 1;71(1):79-82 [1320587] J Antimicrob Chemother. 1992 Oct;30(4):449-62 [1490918] J Biol Chem. 1993 Feb 15;268(5):3690-7 [8429044] Antimicrob Agents Chemother. 1993 Oct;37(10):2059-63 [8257123] Biochemistry. 1994 May 17;33(19):5728-38 [8180199] Antimicrob Agents Chemother. 1994 May;38(5):1085-9 [8067742] J Biol Chem. 1994 Sep 23;269(38):23444-50 [8089110] J Mol Biol. 1994 Dec 16;244(5):625-39 [7990143] Biochim Biophys Acta. 1995 Jan 19;1246(2):109-27 [7819278] Biochim Biophys Acta. 1995 Feb 22;1247(1):113-20 [7873579] Biochim Biophys Acta. 1995 Feb 22;1247(1):121-5 [7873581] Antimicrob Agents Chemother. 1995 Feb;39(2):427-30 [7726509] J Biol Chem. 1995 Aug 4;270(31):18240-5 [7629142] Antimicrob Agents Chemother. 1995 Jun;39(6):1211-33 [7574506] Antimicrob Agents Chemother. 1995 Nov;39(11):2478-83 [8585729] Methods Enzymol. 1987;154:367-82 [3323813] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The glial glutamate transporter in hyperammonemia and hepatic encephalopathy: relation to energy metabolism and glutamatergic neurotransmission. AN - 79279994; 9298855 AB - Abnormalities in glutamate metabolism and glutamatergic neurotransmission appear to play a major role in the pathogenesis of hyperammonemia and hepatic encephalopathy. Astrocytes may be involved in these derangements as ammonia has been shown to impair the ability of these cells to take up glutamate. This study presents a northern blot analysis of the GLT-1 glutamate transporter in hyperammonemic rats, and in rats with thioacetamide-induced acute liver failure. Our findings demonstrate a downregulation of GLT-1 mRNA in both conditions. This article examines the potential impact of deficits in glutamate uptake on energy metabolism and glutamatergic neurotransmission in the context of abnormalities in glial-neuronal interactions. We propose that an ammonia-induced abnormality in astroglial glutamate uptake constitutes a critical aspect in the pathogenesis of hepatic encephalopathy and other hyperammonemic conditions. JF - Glia AU - Norenberg, M D AU - Huo, Z AU - Neary, J T AU - Roig-Cantesano, A AD - Veterans Administration Medical Center and the Department of Pathology, University of Miami School of Medicine, Florida 33101, USA. mnorenbe@mednet.med.miami.edu Y1 - 1997/09// PY - 1997 DA - September 1997 SP - 124 EP - 133 VL - 21 IS - 1 SN - 0894-1491, 0894-1491 KW - Amino Acid Transport System X-AG KW - 0 KW - RNA, Messenger KW - Thioacetamide KW - 075T165X8M KW - Glutamic Acid KW - 3KX376GY7L KW - Ammonia KW - 7664-41-7 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Biological Transport KW - Transcription, Genetic KW - Models, Chemical KW - Energy Metabolism KW - RNA, Messenger -- biosynthesis KW - Citric Acid Cycle KW - Astrocytes -- metabolism KW - Neurons -- metabolism KW - Glutamic Acid -- metabolism KW - ATP-Binding Cassette Transporters -- metabolism KW - Brain -- metabolism KW - Hepatic Encephalopathy -- metabolism KW - Brain -- physiology KW - Neuroglia -- physiology KW - Hepatic Encephalopathy -- chemically induced KW - Brain -- physiopathology KW - Neuroglia -- metabolism KW - Ammonia -- metabolism KW - Neurons -- physiology KW - ATP-Binding Cassette Transporters -- biosynthesis KW - Glutamic Acid -- physiology KW - Synaptic Transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79279994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glia&rft.atitle=The+glial+glutamate+transporter+in+hyperammonemia+and+hepatic+encephalopathy%3A+relation+to+energy+metabolism+and+glutamatergic+neurotransmission.&rft.au=Norenberg%2C+M+D%3BHuo%2C+Z%3BNeary%2C+J+T%3BRoig-Cantesano%2C+A&rft.aulast=Norenberg&rft.aufirst=M&rft.date=1997-09-01&rft.volume=21&rft.issue=1&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=Glia&rft.issn=08941491&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-23 N1 - Date created - 1997-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Isolated tricuspid valve endocarditis in nonaddicted patients: a diagnostic challenge. AN - 79276700; 9298048 AB - Isolated native nonrheumatic tricuspid valve endocarditis rarely is described in the absence of intravenous drug use, intracardiac catheters, or cardiac anomalies. We diagnosed tricuspid valve endocarditis in two elderly nonaddicted patients with recurrent pulmonary infiltrates, anemia, and microscopic hematuria that occurred during several months and was caused by Gemella morbillorum and Candida glabrata, respectively. We have reviewed 27 other cases of nonaddicted patients with tricuspid valve endocarditis from the literature and discussed etiology, clinical characteristics, and outcome. Mean age was 53.5 years (range, 22 to 74 years old), and 72% had underlying medical conditions. Staphylococcus oureus, Streptococcus bovis, and candida species were the causative organisms in 70% of the cases. Average duration of infection before diagnosis was 9.3 months. We conclude that isolated tricuspid valve endocarditis in nonaddicted patients occurs mainly in the middle-aged and older persons, mimicking chronic illness and community-acquired pneumonia. In the absence of a history of intravenous drug use, diagnostic delays are common. We suggest that right-sided endocarditis must be considered in any patient with the "Tricuspid Syndrome," consisting of recurrent pulmonary events, anemia, and microscopic hematuria. Careful evaluation of prior medical records and clinical course can be very helpful. Echocardiography and serial blood cultures provide the key to diagnosis. JF - The American journal of the medical sciences AU - Nandakumar, R AU - Raju, G AD - Department of Medicine, Veterans Administration New Jerssey Health Care System, Lyons 07939-9998, USA. Y1 - 1997/09// PY - 1997 DA - September 1997 SP - 207 EP - 212 VL - 314 IS - 3 SN - 0002-9629, 0002-9629 KW - Abridged Index Medicus KW - Index Medicus KW - Blood -- microbiology KW - Humans KW - Electrocardiography KW - Streptococcal Infections -- diagnosis KW - Candidiasis -- diagnosis KW - Aged KW - Middle Aged KW - Endocarditis, Bacterial -- diagnosis KW - Liver Diseases, Alcoholic -- complications KW - Male KW - Heart Valve Diseases -- diagnosis KW - Heart Valve Diseases -- complications KW - Tricuspid Valve -- pathology KW - Endocarditis -- diagnosis KW - Endocarditis -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79276700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Isolated+tricuspid+valve+endocarditis+in+nonaddicted+patients%3A+a+diagnostic+challenge.&rft.au=Nandakumar%2C+R%3BRaju%2C+G&rft.aulast=Nandakumar&rft.aufirst=R&rft.date=1997-09-01&rft.volume=314&rft.issue=3&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-08 N1 - Date created - 1997-10-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Redox buffering by melanin and Fe(II) in Cryptococcus neoformans. AN - 79259276; 9286986 AB - Melanin is a fungal extracellular redox buffer which, in principle, can neutralize antimicrobial oxidants generated by immunologic effector cells, but its source of reducing equivalents is not known. We wondered whether Fe(II) generated by the external ferric reductase of fungi might have the physiologic function of reducing fungal melanin and thereby promoting pathogenesis. We observed that exposure of a melanin film electrode to reductants decreased the open-circuit potential (OCP) and reduced the area of a cyclic voltammetric reduction wave whereas exposure to oxidants produced the opposite effects. Exposure to 10, 100, 1,000 or 10,000 microM Fe(II) decreased the OCP of melanin by 0.015, 0.038, 0.100, and 0.120 V, respectively, relative to a silver-silver chloride standard, and decreased the area of the cyclic voltammetric reduction wave by 27, 35, 50, and 83%, respectively. Moreover, exposure to Fe(II) increased the buffering capacity by 44%, while exposure to millimolar dithionite did not increase the buffering capacity. The ratio of the amount of bound iron to the amount of the incremental increase in the following oxidation wave was approximately 1.0, suggesting that bound iron participates in buffering. Light absorption by melanin suspensions was decreased 14% by treatment with Fe(II), consistent with reduction of melanin. Light absorption by suspensions of melanized Cryptococcus neoformans was decreased 1.3% by treatment with Fe(II) (P < 0.05). Cultures of C. neoformans generated between 2 and 160 microM Fe(II) in culture supernatant, depending upon the strain and the conditions [the higher values were achieved by a constitutive ferric reductase mutant in high concentrations of Fe(III)]. We infer that Fe(II) can reduce melanin under physiologic conditions; moreover, it binds to melanin and cooperatively increases redox buffering. The data support a model for physiologic redox cycling of fungal melanin, whereby electrons exported by the yeast to form extracellular Fe(II) maintain the reducing capacity of the extracellular redox buffer. JF - Journal of bacteriology AU - Jacobson, E S AU - Hong, J D AD - Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USA. jacobson.eric_s@richmond.va.gov Y1 - 1997/09// PY - 1997 DA - September 1997 SP - 5340 EP - 5346 VL - 179 IS - 17 SN - 0021-9193, 0021-9193 KW - Ferric Compounds KW - 0 KW - Ferrous Compounds KW - Ketoglutaric Acids KW - Melanins KW - Oxidants KW - Reducing Agents KW - Dithionite KW - 14844-07-6 KW - 3-Hydroxyanthranilic Acid KW - 1UQB1BT4OT KW - alpha-ketoglutaric acid KW - 8ID597Z82X KW - Index Medicus KW - Oxidation-Reduction KW - Oxidants -- pharmacology KW - Ketoglutaric Acids -- chemistry KW - Ferric Compounds -- chemistry KW - 3-Hydroxyanthranilic Acid -- chemistry KW - Reducing Agents -- pharmacology KW - Electrochemistry KW - Cryptococcus neoformans -- chemistry KW - Ferrous Compounds -- chemistry KW - Melanins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79259276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Redox+buffering+by+melanin+and+Fe%28II%29+in+Cryptococcus+neoformans.&rft.au=Jacobson%2C+E+S%3BHong%2C+J+D&rft.aulast=Jacobson&rft.aufirst=E&rft.date=1997-09-01&rft.volume=179&rft.issue=17&rft.spage=5340&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-09-30 N1 - Date created - 1997-09-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1995 Dec;63(12):4944-5 [7591162] Infect Immun. 1995 Aug;63(8):3131-6 [7622240] Arch Biochem Biophys. 1960 Feb;86:225-30 [14422053] Free Radic Biol Med. 1988;4(5):285-93 [2834276] Infect Immun. 1990 Sep;58(9):2919-22 [2117574] J Bacteriol. 1991 Jan;173(1):401-3 [1898925] Ann Neurol. 1992;32 Suppl:S69-75 [1510383] J Med Vet Mycol. 1992;30(6):443-50 [1287163] J Bacteriol. 1993 Nov;175(21):7102-4 [8226653] Life Sci. 1967 Dec 15;6(24):2605-12 [4295440] Mol Pharmacol. 1971 Jul;7(4):429-33 [5000218] Br J Dermatol. 1977 Jul;97(1):109-12 [889693] N Engl J Med. 1978 Mar 23;298(12):659-68 [24176] J Bacteriol. 1982 Jun;150(3):1414-21 [6804444] Biochim Biophys Acta. 1986 Aug 6;883(1):162-7 [3015231] J Med Vet Mycol. 1987 Apr;25(2):97-106 [3598824] J Gen Microbiol. 1987 Nov;133(11):3229-36 [3328775] Infect Immun. 1994 Jul;62(7):3004-7 [8005689] Infect Immun. 1997 Feb;65(2):434-8 [9009293] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Obsessive-compulsive disorder following bilateral globus pallidus infarction. AN - 79241193; 9276081 JF - Biological psychiatry AU - Rodrigo Escalona, P AU - Adair, J C AU - Roberts, B B AU - Graeber, D A AD - Albuquerque Veterans Administration Medical Center, New Mexico 87108, USA. Y1 - 1997/09/01/ PY - 1997 DA - 1997 Sep 01 SP - 410 EP - 412 VL - 42 IS - 5 SN - 0006-3223, 0006-3223 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Suicide, Attempted KW - Humans KW - Adult KW - Carbon Monoxide Poisoning -- complications KW - Carbon Monoxide Poisoning -- psychology KW - Male KW - Globus Pallidus -- pathology KW - Obsessive-Compulsive Disorder -- etiology KW - Cerebral Infarction -- pathology KW - Obsessive-Compulsive Disorder -- pathology KW - Cerebral Infarction -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79241193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Obsessive-compulsive+disorder+following+bilateral+globus+pallidus+infarction.&rft.au=Rodrigo+Escalona%2C+P%3BAdair%2C+J+C%3BRoberts%2C+B+B%3BGraeber%2C+D+A&rft.aulast=Rodrigo+Escalona&rft.aufirst=P&rft.date=1997-09-01&rft.volume=42&rft.issue=5&rft.spage=410&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-17 N1 - Date created - 1997-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - c-fms mRNA is regulated posttranscriptionally by 1,25(OH)2D3 in HL-60 cells. AN - 79227148; 9262511 AB - Macrophage colony-stimulating factor (MCSF) is required for normal osteoclast and macrophage development. The receptor for MCSF (c-fms) is expressed on the pluripotent precursor and mature osteoclasts and macrophages. We have previously shown in myelomonocytic HL-60 cells that phorbol myristate acetate (PMA) upregulates c-fms mRNA expression. This induction of c-fms is inhibited by 1,25(OH)2D3. The major regulatory control of c-fms mRNA levels by PMA has been identified as posttranscriptional. However, a role of transcript elongation in controlling levels of c-fms mRNA has also been suggested. To better understand the 1,25(OH)2D3 regulation of c-fms mRNA expression we studied nuclear run on, mRNA stability, and transcript elongation in HL-60 cells treated with 10 ng/ml phorbol myristate acetate, 10 nM 1,25(OH)2D3 alone or combined. We demonstrated by nuclear run on that c-fms was constitutively transcribed in 1,25(OH)2D3 as well as control and PMA-treated cells. Transcript elongation was evaluated by RT-PCR for exon 2 or exon 3. Both exons were minimally expressed in control and 1,25(OH)2D3-treated cells, and increased in PMA-treated cells; this increased expression was inhibited by the addition of 1,25(OH)2D3. These results fail to show differential transcript elongation. Measurement of mRNA stability demonstrated decreased mRNA half-life to 5 hours in cells treated with PMA and 1,25(OH)2D3 compared with a half-life of 8 hours in cells treated with PMA alone. Our findings demonstrate that c-fms is regulated by 1,25(OH)2D3 at the posttranscriptional level by changes in mRNA stability. This gives the cell the ability to respond to local signals with rapid changes in c-fms levels altering the ability of the cell to respond to MCSF. JF - Calcified tissue international AU - Biskobing, D M AU - Fan, D AU - Rubin, J AD - Department of Medicine, Emory Uiversity Medical School and Veterans Administration Medical Center, Atlanta, Georgia 30033, USA. Y1 - 1997/09// PY - 1997 DA - September 1997 SP - 205 EP - 209 VL - 61 IS - 3 SN - 0171-967X, 0171-967X KW - Mitogens KW - 0 KW - RNA, Messenger KW - Receptor, Macrophage Colony-Stimulating Factor KW - EC 2.7.10.1 KW - Calcitriol KW - FXC9231JVH KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Mitogens -- pharmacology KW - Transcription, Genetic -- drug effects KW - HL-60 Cells KW - Humans KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Receptor, Macrophage Colony-Stimulating Factor -- genetics KW - RNA Processing, Post-Transcriptional -- drug effects KW - Calcitriol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79227148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Calcified+tissue+international&rft.atitle=c-fms+mRNA+is+regulated+posttranscriptionally+by+1%2C25%28OH%292D3+in+HL-60+cells.&rft.au=Biskobing%2C+D+M%3BFan%2C+D%3BRubin%2C+J&rft.aulast=Biskobing&rft.aufirst=D&rft.date=1997-09-01&rft.volume=61&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Calcified+tissue+international&rft.issn=0171967X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-22 N1 - Date created - 1997-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Unmethylated CpG-containing oligodeoxynucleotides inhibit apoptosis in WEHI 231 B lymphocytes induced by several agents: evidence for blockade of apoptosis at a distal signalling step. AN - 79391827; 9378499 AB - Certain oligodeoxynucleotides (ODN) containing cytosine followed by guanosine (CpG) protect B cells from apoptosis, and induce B-cell proliferation and cytokine production. We investigated the effect of phosphorothioate CpG-containing ODNs (5'-ATAATCGACGTTCAAGCAAG-3' or 5'-TCCATGACGTTCCTGACGTT-3') and control ODNs (which did not contain CpG) on apoptosis and cell growth in WEHI 231 murine B lymphoma cells. Anti-surface (alpha-s)IgM antibody induces 40-60% DNA degradation and growth arrest of WEHI 231 cells in 24 h. Both of these effects were substantially reversed by 30 ng/ml CpG-ODN added up to 8 hr after alpha-sIgM. Control ODNs not containing the CpG motif were without effect. We explored various hypotheses to account for these effects. The phorbol ester, 12-O-tetradecanoyl phorbol-13-acetate, inhibits apoptosis induced by alpha-sIgM, but the anti-apoptotic effect of CpG-ODN was not affected by inhibitors of protein kinase C, indicating that CpG-ODN does not act via protein kinase C. CpG-ODN inhibited apoptosis and growth arrest induced by C2- and C8-ceramide, sphingomyelinase and an intracellular Ca2+ pump inhibitor thapsigargin, indicating that inhibition is not mediated via suppression of the ceramide cycle or suppression of Ca2+ mobilization. CpG-ODN partially inhibited apoptosis induced by okadaic acid, a protein phosphatase inhibitor, and by menadione, a free radical generator. CpG-ODN also inhibited apoptosis and growth arrest induced by ultraviolet-irradiation, glucocorticoid, vinca alkaloids, and doxorubicin. CpG-ODN significantly protected cells from DNA fragmentation induced by alpha-sIgM in the presence of cycloheximide, but cycloheximide itself induces apoptosis which was unaffected by CpG-ODN. These results suggest that CpG-ODNs powerfully modulate the process by which immune cells are committed to death or proliferation by a mechanism acting on distal cell signalling events. CpG-ODNs may be able to decrease immunosuppression in patients undergoing cancer chemotherapy. JF - Immunology AU - Macfarlane, D E AU - Manzel, L AU - Krieg, A M AD - Department of Medicine, Veterans Administration Hospital, USA. Y1 - 1997/08// PY - 1997 DA - August 1997 SP - 586 EP - 593 VL - 91 IS - 4 SN - 0019-2805, 0019-2805 KW - Antineoplastic Agents KW - 0 KW - Oligonucleotides KW - Protein Synthesis Inhibitors KW - Sphingomyelins KW - Vitamin K KW - 12001-79-5 KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Thapsigargin KW - 67526-95-8 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Index Medicus KW - Thapsigargin -- pharmacology KW - Okadaic Acid -- antagonists & inhibitors KW - Animals KW - Tumor Cells, Cultured KW - Protein Synthesis Inhibitors -- pharmacology KW - Sphingomyelins -- immunology KW - Vitamin K -- pharmacology KW - DNA Fragmentation -- drug effects KW - Mice KW - Protein Kinase C -- immunology KW - Antineoplastic Agents -- antagonists & inhibitors KW - B-Lymphocytes -- drug effects KW - Oligonucleotides -- pharmacology KW - Oligonucleotides -- chemistry KW - CpG Islands -- immunology KW - Signal Transduction -- drug effects KW - Apoptosis -- drug effects KW - B-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79391827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology&rft.atitle=Unmethylated+CpG-containing+oligodeoxynucleotides+inhibit+apoptosis+in+WEHI+231+B+lymphocytes+induced+by+several+agents%3A+evidence+for+blockade+of+apoptosis+at+a+distal+signalling+step.&rft.au=Macfarlane%2C+D+E%3BManzel%2C+L%3BKrieg%2C+A+M&rft.aulast=Macfarlane&rft.aufirst=D&rft.date=1997-08-01&rft.volume=91&rft.issue=4&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=Immunology&rft.issn=00192805&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-11-07 N1 - Date created - 1997-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1995 May 4;375(6526):78-81 [7536900] Nature. 1995 Apr 6;374(6522):546-9 [7700380] Eur J Immunol. 1995 May;25(5):1352-7 [7539757] Blood Rev. 1995 Mar;9(1):53-6 [7540904] J Immunol. 1995 Jul 1;155(1):66-75 [7602123] Science. 1995 Nov 24;270(5240):1326-31 [7481820] Blood. 1996 Jan 1;87(1):202-10 [8547643] Science. 1996 Apr 5;272(5258):50-3 [8600536] J Immunol. 1996 Apr 1;156(7):2345-8 [8786287] Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2879-83 [8610135] Nature. 1996 Jun 27;381(6585):751-8 [8657279] Trends Microbiol. 1996 Feb;4(2):73-6 [8820571] J Immunol. 1996 Dec 1;157(11):4918-25 [8943396] J Immunol. 1981 Jun;126(6):2466-9 [6785356] J Immunol. 1984 Jan;132(1):38-42 [6317746] J Pathol. 1984 Jan;142(1):67-77 [6422024] Cell Immunol. 1985 Jun;93(1):124-31 [3922631] J Immunol. 1991 Sep 15;147(6):1759-64 [1890302] Microbiol Immunol. 1992;36(9):983-97 [1281260] J Immunol. 1993 Sep 15;151(6):2965-73 [8376764] Cell. 1993 Oct 22;75(2):241-51 [7503812] J Cell Biochem. 1993 Nov;53(3):222-33 [8263039] Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):73-7 [8278410] J Biol Chem. 1994 Feb 4;269(5):3125-8 [8106344] J Immunol. 1994 Mar 15;152(6):2821-9 [7511629] Exp Cell Res. 1994 May;212(1):84-92 [8174645] Exp Cell Res. 1994 Jul;213(1):100-6 [8020578] Science. 1995 Mar 10;267(5203):1445-9 [7878463] Eur J Immunol. 1995 Apr;25(4):1032-8 [7537668] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Conduct disorder and antisocial personality in adult primary care patients. AN - 79217634; 9267374 AB - Conduct disorder has been linked to substance use disorders in clinical populations. This study examined the relationships of conduct disorder and antisocial personality (ASP) disorder to substance use, substance abuse problems, depression, and demographic factors in primary care settings. As part of a larger clinical trial, a survey of 1898 patients in the offices of 64 primary care physicians was conducted using a self-administered health habits questionnaire. Childhood conduct disorder and adult antisocial personality disorder were assessed using criteria from the Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised. Eight percent of men and 3.1% of women met criteria for a diagnosis of ASP disorder. The frequency of a history of childhood conduct disorders was higher, with 13.4% for men and 4% for women. Antisocial personality disorder was predicted by male sex, being unmarried (single, separated, divorced), lifetime history of depression, binge drinking, self-reported history of drug problems, current smoking, and younger age. The predictors of a history of child conduct disorder were similar to those of ASP. Primary care physicians treat many patients who have personality disorders and other conditions such as alcohol problems and depression. These patients need to be identified because of the high potential for comorbidity and the barriers to treatment inherent in these disorders. JF - The Journal of family practice AU - Barry, K L AU - Fleming, M F AU - Manwell, L B AU - Copeland, L A AD - Veterans Administration, Serious Mental Illness Treatment Research and Evaluation Center, Ann Arbor, MI 48113-0170, USA. Y1 - 1997/08// PY - 1997 DA - August 1997 SP - 151 EP - 158 VL - 45 IS - 2 SN - 0094-3509, 0094-3509 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Retrospective Studies KW - Aged KW - Child KW - Alcohol Drinking KW - Demography KW - Smoking KW - Cross-Sectional Studies KW - Aged, 80 and over KW - Wisconsin -- epidemiology KW - Adult KW - Substance-Related Disorders -- complications KW - Middle Aged KW - Child Behavior Disorders -- complications KW - Adolescent KW - Male KW - Child Behavior Disorders -- epidemiology KW - Female KW - Substance-Related Disorders -- epidemiology KW - Prevalence KW - Antisocial Personality Disorder -- epidemiology KW - Antisocial Personality Disorder -- complications KW - Family Practice -- statistics & numerical data KW - Mental Disorders -- epidemiology KW - Mental Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79217634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+family+practice&rft.atitle=Conduct+disorder+and+antisocial+personality+in+adult+primary+care+patients.&rft.au=Barry%2C+K+L%3BFleming%2C+M+F%3BManwell%2C+L+B%3BCopeland%2C+L+A&rft.aulast=Barry&rft.aufirst=K&rft.date=1997-08-01&rft.volume=45&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+family+practice&rft.issn=00943509&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-09-08 N1 - Date created - 1997-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanisms of drug-induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo. AN - 79207560; 9259423 AB - T cells treated with DNA methylation inhibitors overexpress lymphocyte function-associated antigen 1 (LFA-1), which results in autoreactivity, and the autoreactive cells cause a lupus-like disease in vivo, suggesting a mechanism by which some agents may cause drug-induced lupus. This study compared the effects of procainamide (Pca) and hydralazine (Hyd) with those of structural analogs, to determine if the degree of LFA-1 overexpression and T cell autoreactivity correlated with the ability of the agents to induce autoimmunity. Cloned murine T helper 2 cells were treated with Pca, N-acetylprocainamide, Hyd, Phthalazine, or hydroxyurea (HU). The treated cells were then compared for LFA-1 overexpression, autoreactivity, and the ability to induce autoimmunity in vivo. Pca and Hyd were more potent than their analogs or HU in all 3 assays. The results support a relationship between LFA-1 overexpression, T cell autoreactivity, and autoimmunity, and suggest a mechanism by which Pca and Hyd, but not the analogs, may cause drug-induced lupus. JF - Arthritis and rheumatism AU - Yung, R AU - Chang, S AU - Hemati, N AU - Johnson, K AU - Richardson, B AD - University of Michigan, Ann Arbor, and the Ann Arbor Veterans Administration Hospital, 48109-0531, USA. Y1 - 1997/08// PY - 1997 DA - August 1997 SP - 1436 EP - 1443 VL - 40 IS - 8 SN - 0004-3591, 0004-3591 KW - Autoantibodies KW - 0 KW - Lymphocyte Function-Associated Antigen-1 KW - Hydralazine KW - 26NAK24LS8 KW - Procainamide KW - L39WTC366D KW - Hydroxyurea KW - X6Q56QN5QC KW - Abridged Index Medicus KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Lymphocyte Function-Associated Antigen-1 -- genetics KW - Procainamide -- adverse effects KW - Lymphocyte Function-Associated Antigen-1 -- biosynthesis KW - Antibody Formation KW - Autoantibodies -- immunology KW - Autoimmunity KW - Mice KW - Hydroxyurea -- adverse effects KW - Lymphocyte Activation -- drug effects KW - T-Lymphocytes -- metabolism KW - Mice, Inbred NZB KW - DNA Methylation -- drug effects KW - Hydralazine -- adverse effects KW - T-Lymphocytes -- immunology KW - Mice, Inbred AKR KW - Male KW - Female KW - Lupus Vulgaris -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79207560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+and+rheumatism&rft.atitle=Mechanisms+of+drug-induced+lupus.+IV.+Comparison+of+procainamide+and+hydralazine+with+analogs+in+vitro+and+in+vivo.&rft.au=Yung%2C+R%3BChang%2C+S%3BHemati%2C+N%3BJohnson%2C+K%3BRichardson%2C+B&rft.aulast=Yung&rft.aufirst=R&rft.date=1997-08-01&rft.volume=40&rft.issue=8&rft.spage=1436&rft.isbn=&rft.btitle=&rft.title=Arthritis+and+rheumatism&rft.issn=00043591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-09-08 N1 - Date created - 1997-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An open trial of transdermal nicotine replacement therapy for smoking cessation among alcohol- and drug-dependent inpatients. AN - 79402111; 9368209 AB - An open trial of transdermal nicotine replacement for smoking cessation was conducted. Over a 7-month period, all patients admitted to the inpatient alcohol and drug treatment unit of the Seattle Veterans Affairs Medical Center, (n = 207) were offered the opportunity to participate in an open trial of transdermal nicotine replacement for smoking cessation. Forty-nine (23.7%) elected to attempt cessation with transdermal nicotine during their inpatient treatment episodes. These subjects received no psychosocial treatments directed specifically at smoking cessation. They smoked a mean of 28.5 (SD = 16.4) cigarettes per day and obtained a mean score of 8.3 (SD = 1.9) on the Fagerstrom Test for Nicotine Dependence. Subjects remained on transdermal nicotine an average of 18.8 (SD = 8.2) days with desire to resume smoking the major reason for discontinuation. Seven subjects (14.3%) self-reported tobacco abstinence at 21 days, and 5 (10.2%) self-reported abstinence as outpatients at 6 weeks. These results show that a substantial proportion of alcohol- and drug-dependent patients entering inpatient treatment are willing to attempt alcohol and illicit drug cessation and tobacco cessation simultaneously and that transdermal nicotine holds promise as a treatment modality in this population. JF - Journal of substance abuse treatment AU - Saxon, A J AU - McGuffin, R AU - Walker, R D AD - VA Puget Sound Health Care System, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, USA. Saxon.Andrew_J+@Seattle.VA.Gov PY - 1997 SP - 333 EP - 337 VL - 14 IS - 4 SN - 0740-5472, 0740-5472 KW - Nicotinic Agonists KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Administration, Cutaneous KW - Humans KW - Adult KW - Smoking -- psychology KW - Male KW - Female KW - Nicotine -- therapeutic use KW - Smoking Cessation -- psychology KW - Nicotinic Agonists -- therapeutic use KW - Nicotine -- adverse effects KW - Smoking Cessation -- methods KW - Nicotine -- administration & dosage KW - Substance-Related Disorders -- complications KW - Nicotinic Agonists -- adverse effects KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Alcoholism -- complications KW - Nicotinic Agonists -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79402111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=An+open+trial+of+transdermal+nicotine+replacement+therapy+for+smoking+cessation+among+alcohol-+and+drug-dependent+inpatients.&rft.au=Saxon%2C+A+J%3BMcGuffin%2C+R%3BWalker%2C+R+D&rft.aulast=Saxon&rft.aufirst=A&rft.date=1997-07-01&rft.volume=14&rft.issue=4&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-01-07 N1 - Date created - 1998-01-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thermal epiglottitis in adults: a new complication of illicit drug use. AN - 79248444; 9279700 AB - Four cases of acute epiglottitis due to thermal injury were identified in a larger study of 407 cases of epiglottitis in Rhode Island from 1975 through 1992. All occurred in young adults (aged 22-33 yr) and were caused by the inhalation of heated objects when smoking illicit drugs (a tip of a marijuana cigarette in 1 case and metal pieces from crack cocaine pipes in 3 cases). Symptoms, signs, and X-ray and laryngoscopic findings were similar to infectious epiglottitis. All recovered with observation and intravenous antibiotics; none required intubation. Emergency physicians should be aware of this etiology when managing young adults who present with acute epiglottitis. JF - The Journal of emergency medicine AU - Mayo-Smith, M F AU - Spinale, J AD - Veterans Administration Medical Center, Manchester, New Hampshire 03104, USA. PY - 1997 SP - 483 EP - 485 VL - 15 IS - 4 SN - 0736-4679, 0736-4679 KW - Crack Cocaine KW - 0 KW - Index Medicus KW - Humans KW - Adult KW - Retrospective Studies KW - Female KW - Burns, Inhalation -- etiology KW - Marijuana Smoking -- adverse effects KW - Epiglottitis -- etiology KW - Substance-Related Disorders -- complications KW - Foreign Bodies KW - Burns, Inhalation -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79248444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+emergency+medicine&rft.atitle=Thermal+epiglottitis+in+adults%3A+a+new+complication+of+illicit+drug+use.&rft.au=Mayo-Smith%2C+M+F%3BSpinale%2C+J&rft.aulast=Mayo-Smith&rft.aufirst=M&rft.date=1997-07-01&rft.volume=15&rft.issue=4&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+emergency+medicine&rft.issn=07364679&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-10-22 N1 - Date created - 1997-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Successful hand revascularization with urokinase following a crush injury. AN - 79149736; 9229101 AB - Acute hand ischemia is a medical emergency requiring immediate treatment. We report a case of acute hand ischemia due to a crush injury of the wrist. Management with urokinase was successful in reestablishing flow to the ulnar artery and the digital vessels. In the setting of acute trauma with extensive thrombosis of the vessels of the hand, thrombolytic therapy may offer a better treatment option than surgical exploration with bypass grafting. JF - Annals of plastic surgery AU - Wheatley, M J AU - Swift, R AD - Department of Surgery, Oregon Health Sciences University, Portland Veterans Administration Medical Center 97201-3098, USA. Y1 - 1997/07// PY - 1997 DA - July 1997 SP - 94 EP - 96 VL - 39 IS - 1 SN - 0148-7043, 0148-7043 KW - Urokinase-Type Plasminogen Activator KW - EC 3.4.21.73 KW - Index Medicus KW - Radial Artery -- diagnostic imaging KW - Animals KW - Ulnar Artery -- diagnostic imaging KW - Combined Modality Therapy KW - Humans KW - Bone Wires KW - Postoperative Complications -- surgery KW - Angiography KW - Joint Dislocations -- diagnostic imaging KW - Ulnar Artery -- injuries KW - Middle Aged KW - Joint Dislocations -- surgery KW - Radial Artery -- injuries KW - Female KW - Postoperative Complications -- diagnostic imaging KW - Thrombolytic Therapy KW - Urokinase-Type Plasminogen Activator -- administration & dosage KW - Ischemia -- diagnostic imaging KW - Ischemia -- surgery KW - Wrist Injuries -- surgery KW - Horses KW - Emergencies KW - Hand -- blood supply KW - Hand Injuries -- surgery KW - Bites and Stings -- surgery KW - Hand Injuries -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79149736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+plastic+surgery&rft.atitle=Successful+hand+revascularization+with+urokinase+following+a+crush+injury.&rft.au=Wheatley%2C+M+J%3BSwift%2C+R&rft.aulast=Wheatley&rft.aufirst=M&rft.date=1997-07-01&rft.volume=39&rft.issue=1&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=Annals+of+plastic+surgery&rft.issn=01487043&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-08-19 N1 - Date created - 1997-08-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Deoxycytidine in human plasma: potential for protecting leukemic cells during chemotherapy. AN - 79110344; 9215860 AB - Degradation of DNA produces deoxycytidine. Metabolism of deoxycytidine to dCTP inhibits phosphorylation of cytosine arabinoside (araC), fludarabine (FaraA) and 2-chlorodeoxyadenosine (CdA) by deoxycytidine kinase. This study measured plasma deoxycytidine in healthy adults and two leukemia patients and then determined how clinically relevant deoxycytidine levels would affect drug toxicity in human leukemia and lymphoma cells. Deoxycytidine was well below 0.05 microM in ten healthy persons. In the leukemia patients it was <0.05 and 0.44 microM before chemotherapy, rising to 10.3 and 5.5 microM during treatment. A broad range of clinically relevant deoxycytidine levels were high enough to profoundly decrease araC, FaraA and CdA toxicity in MOLT3, CA46 and HL60 leukemia/lymphoma cells and to change dCTP, DNA synthesis and drug incorporation into DNA in a manner consistent with prior mechanistic studies. Varying deoxycytidine levels could be an important factor influencing leukemia therapy. JF - Cancer letters AU - Cohen, J D AU - Strock, D J AU - Teik, J E AU - Katz, T B AU - Marcel, P D AD - Division of Medical Oncology, University of Colorado Health Sciences Center and Denver Veterans Administration Medical Center, 80262, USA. Y1 - 1997/06/24/ PY - 1997 DA - 1997 Jun 24 SP - 167 EP - 175 VL - 116 IS - 2 SN - 0304-3835, 0304-3835 KW - Deoxycytosine Nucleotides KW - 0 KW - Cytarabine KW - 04079A1RDZ KW - Deoxycytidine KW - 0W860991D6 KW - 2'-deoxycytidine 5'-triphosphate KW - 2056-98-6 KW - Cladribine KW - 47M74X9YT5 KW - Vidarabine KW - FA2DM6879K KW - fludarabine KW - P2K93U8740 KW - Index Medicus KW - Vidarabine -- metabolism KW - Deoxycytosine Nucleotides -- metabolism KW - Vidarabine -- analogs & derivatives KW - Vidarabine -- toxicity KW - Cladribine -- metabolism KW - Cladribine -- toxicity KW - Humans KW - Cytarabine -- toxicity KW - Adult KW - Cytarabine -- metabolism KW - Middle Aged KW - Male KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- blood KW - Deoxycytidine -- blood KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79110344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Deoxycytidine+in+human+plasma%3A+potential+for+protecting+leukemic+cells+during+chemotherapy.&rft.au=Cohen%2C+J+D%3BStrock%2C+D+J%3BTeik%2C+J+E%3BKatz%2C+T+B%3BMarcel%2C+P+D&rft.aulast=Cohen&rft.aufirst=J&rft.date=1997-06-24&rft.volume=116&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-07-28 N1 - Date created - 1997-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - External beam radiation therapy for squamous cell carcinoma of the soft palate. AN - 85280653; pmid-9231673 AB - PURPOSE: External beam radiation therapy for carcinoma of the soft palate aims to achieve loco-regional control with normal speech, nasal function, swallowing mechanism, and minimal side effects such as nasal speech and regurgitation of food into the nasopharynx. In this report we present our results of radiotherapy in the treatment of 24 patients with squamous cell carcinoma of the soft palate. METHODS AND MATERIALS: A total of 24 patients with squamous cell carcinoma of the soft palate were treated at the Veterans Administration Medical Center Minneapolis, MN, between February 1977 and May 1992. Of the 24 patients 2 had T1, 19 T2, 1 T3, and 2 had T4 lesions. Nineteen patients did not have clinical nodal disease, stage (N0), 1 had N1, 2 N2, and 2 N3 disease (Table 1). All the patients were treated by 4 MeV linear accelerator. A 1.75 Gy median dose was administered per fraction to a total of 70 Gy median dose. Bilateral opposed compensated shrinking fields technique was used. RESULTS: The 3-year disease free survival rate after external beam radiation therapy was 100% (1 out of 1), 64.7% (11 out of 17), 100% (1 out of 1), and 0%, for patients with T1, T2, T3, and T4 disease, respectively. Salvage surgery for recurrent disease was successful in 57.1% (4 out of 7 patients (Table 2). The ultimate 3-year disease free survival rate for the entire group, including surgical salvage, was 81% (17 out of 21) (Fig 1). CONCLUSION: Radiation therapy alone in our institution resulted in tumor control and survival rates compare favorably to previously published reports in the literature. Surgery can be reserved as salvage procedure. JF - International Journal of Radiation Oncology, Biology, Physics AU - Medini, E AU - Medini, A AU - Gapany, M AU - Levitt, S H AD - Department of Radiation Oncology and Otolaryngology, University of Minnesota, and Veterans Administration Medical Center, Minneapolis 55417, USA. PY - 1997 SP - 507 EP - 511 VL - 38 IS - 3 SN - 0360-3016, 0360-3016 KW - Neoplasm Staging KW - Human KW - Salvage Therapy KW - Aged KW - Middle Age KW - Follow-Up Studies KW - Carcinoma, Squamous Cell KW - Male KW - Palatal Neoplasms KW - Palate, Soft UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85280653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics&rft.atitle=External+beam+radiation+therapy+for+squamous+cell+carcinoma+of+the+soft+palate.&rft.au=Medini%2C+E%3BMedini%2C+A%3BGapany%2C+M%3BLevitt%2C+S+H&rft.aulast=Medini&rft.aufirst=E&rft.date=1997-06-01&rft.volume=38&rft.issue=3&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics&rft.issn=03603016&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Malignant transformation in a duodenal villous adenoma of the afferent limb of Billroth II anastomosis. AN - 85207045; pmid-9252865 JF - Journal of Clinical Gastroenterology AU - Kapur, A AU - Demian, S AU - Heinzelmann, E J AU - al-Assaad, Z AU - Howden, C W AU - Vasudeva, R AD - Department of Medicine, Dorn Veterans' Administration Hospital, Columbia, South Carolina. PY - 1997 SP - 290 EP - 291 VL - 24 IS - 4 SN - 0192-0790, 0192-0790 KW - Duodenal Neoplasms KW - Adenoma, Villous KW - Human KW - Gastrointestinal Hemorrhage KW - Aged KW - Case Report KW - Adenocarcinoma KW - Time Factors KW - Male KW - Anemia, Iron-Deficiency KW - Gastroenterostomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85207045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Malignant+transformation+in+a+duodenal+villous+adenoma+of+the+afferent+limb+of+Billroth+II+anastomosis.&rft.au=Kapur%2C+A%3BDemian%2C+S%3BHeinzelmann%2C+E+J%3Bal-Assaad%2C+Z%3BHowden%2C+C+W%3BVasudeva%2C+R&rft.aulast=Kapur&rft.aufirst=A&rft.date=1997-06-01&rft.volume=24&rft.issue=4&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Sincalide: a cholecystokinin agonist as an aid in endoscopic retrograde cholangiopancreatography--a prospective assessment. AN - 85205599; pmid-9252846 AB - Although several approaches to overcome difficult bile duct cannulation and gain free biliary access have been popularized, the use of gastrointestinal peptide hormonal agents such as sincalide, a cholecystokinin agonist, as an alternative method has not been evaluated. I have carried out a prospective, nonrandomized assessment of the use of sincalide for diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). Overall, sincalide was used in 23% (32/136) of ERCPs in 26.6% (29/109) patients. Sincalide was successfully used to (a) obtain a cholangiogram after initial failure using only a standard catheter in 12 of 19 patients; (b) precisely locate the papilla and bile duct orifice in five of five patients; (c) locate the bile duct opening to obtain a cholangiogram and free cannulation during needle-knife papillotomy or weeks later in five of seven and three of three patients, respectively; and (d) gain free access (deep cannulation) to the bile duct after a cholangiogram in 5 of 10 patients. The selected use of sincalide appears to enhance the success of diagnostic and therapeutic ERCP; however, perseverance alone may account for some of this success. Controlled, randomized trials comparing sincalide or nothing, sincalide or a sphincterotome, or sincalide or glide or guide wire in patients in whom initial attempts to obtain a cholangiogram are unsuccessful are warranted. JF - Journal of Clinical Gastroenterology AU - Weston, A P AD - Gastroenterology Section (111C), Veterans Administration Medical Center, Kansas City, MO 64128, USA. PY - 1997 SP - 227 EP - 230 VL - 24 IS - 4 SN - 0192-0790, 0192-0790 KW - Sincalide KW - Prospective Studies KW - Cholecystokinin KW - Biliary Tract Diseases KW - Human KW - Support, U.S. Gov't, Non-P.H.S. KW - Cholangiopancreatography, Endoscopic Retrograde UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85205599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Sincalide%3A+a+cholecystokinin+agonist+as+an+aid+in+endoscopic+retrograde+cholangiopancreatography--a+prospective+assessment.&rft.au=Weston%2C+A+P&rft.aulast=Weston&rft.aufirst=A&rft.date=1997-06-01&rft.volume=24&rft.issue=4&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Red cell age by flow cytometry. AN - 79171930; 9247886 AB - A method is presented for the use of red cell markers to assess the age of red cells in clinical samples. The reticulocyte count and its variants are already in clinical use to measure the number of young circulating red cells, but tools have not been put into place for studying the overall distribution of red cell age. These data could be of significant value, not merely for hematologic investigations, but as a part of infectious disease, renal, and toxicologic studies. JF - Medical hypotheses AU - Nusbaum, N J AD - Department of Medicine, Tulane University, School of Medicine, New Orleans VA Medical Center, USA. nusbaum.neil@new-orleans.va.gov Y1 - 1997/06// PY - 1997 DA - June 1997 SP - 469 EP - 472 VL - 48 IS - 6 SN - 0306-9877, 0306-9877 KW - Hemoglobin A, Glycosylated KW - 0 KW - Index Medicus KW - Humans KW - Hemoglobin A, Glycosylated -- metabolism KW - Cell Separation -- methods KW - Erythrocytes -- cytology KW - Erythrocyte Aging KW - Erythrocytes -- metabolism KW - Flow Cytometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79171930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+hypotheses&rft.atitle=Red+cell+age+by+flow+cytometry.&rft.au=Nusbaum%2C+N+J&rft.aulast=Nusbaum&rft.aufirst=N&rft.date=1997-06-01&rft.volume=48&rft.issue=6&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Medical+hypotheses&rft.issn=03069877&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-09-29 N1 - Date created - 1997-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Schwann cell changes induced as early as one week after galactose intoxication. AN - 79072097; 9194901 AB - In galactose neuropathy, aldose reductase inhibitor (ARI)-preventable Schwann cell injury has been reported in studies in which galactose feeding continued over a period of months. Given the link between these morphologic changes and polyol pathway flux, polyol accumulation after just days of galactose feeding points to the possibility that structural changes occur much earlier than previously reported. The aim of this study was to examine rat sciatic nerve after 7 days of galactose feeding for evidence of myelinated fiber injury and establish whether it is related to polyol accumulation. Compared to control or ARI-treated galactose-fed rats, nerves from untreated galactose-fed rats had increased water (P < 0.05) ad dulcitol (P < 0.008) content and decreased amounts of myo-inositol (P < 0.01). Electron microscopy revealed reactive Schwann cell changes in myelinated fibers characterized by increased cytoplasmic volume, and the occurrence of lipid droplets pi granules of Reich and enlarged mitochondria. Dystrophic accumulation of intermediate filaments was also observed in the inner glial loop. Degenerative changes included periaxonal swelling, enlarged mitochondria without recognizable cristae, lysis of Schwann cell cytoplasm and demyelination. Reactive (P < 0.05) and degenerative (P < 0.01) changes as well as the number of redundant basal lamina profiles (P < 0.05) were significantly more frequent in untreated galactose-fed rats compared to controls. ARI treatment attenuated these changes. Consistent with the initial stages of onion-bulb formation, profiles with imbricate Schwann cells were also seen only in untreated galactose-fed rats. The findings suggest that short-term increases in polyol pathway activity can have deleterious effects Schwann cells of myelinated fibers. JF - Acta neuropathologica AU - Mizisin, A P AU - Powell, H C AD - Veterans Administration Medical Center, San Diego, La Jolla, CA, USA. amizisin@ucsd.edu Y1 - 1997/06// PY - 1997 DA - June 1997 SP - 611 EP - 618 VL - 93 IS - 6 SN - 0001-6322, 0001-6322 KW - Aldehyde Reductase KW - EC 1.1.1.21 KW - Galactose KW - X2RN3Q8DNE KW - Index Medicus KW - Rats KW - Diabetic Neuropathies -- chemically induced KW - Administration, Oral KW - Animals KW - Sciatic Nerve -- ultrastructure KW - Rats, Sprague-Dawley KW - Drug Administration Schedule KW - Diabetic Neuropathies -- pathology KW - Aldehyde Reductase -- antagonists & inhibitors KW - Sciatic Nerve -- pathology KW - Time Factors KW - Sciatic Nerve -- drug effects KW - Female KW - Schwann Cells -- ultrastructure KW - Schwann Cells -- drug effects KW - Galactose -- toxicity KW - Schwann Cells -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79072097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+neuropathologica&rft.atitle=Schwann+cell+changes+induced+as+early+as+one+week+after+galactose+intoxication.&rft.au=Mizisin%2C+A+P%3BPowell%2C+H+C&rft.aulast=Mizisin&rft.aufirst=A&rft.date=1997-06-01&rft.volume=93&rft.issue=6&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Acta+neuropathologica&rft.issn=00016322&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-08-05 N1 - Date created - 1997-08-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence and risk factors for posttraumatic stress disorder among chemically dependent adolescents. AN - 79025922; 9167501 AB - This study ascertained the prevalence of posttraumatic stress disorder (PTSD) among chemically dependent adolescents and identified factors that influence the risk of PTSD after a qualifying trauma. The study group consisted of 297 adolescents aged 15-19 years who met the DSM-III-R criteria for dependence on alcohol or other drugs and who were receiving treatment in seven publicly funded Massachusetts facilities. PTSD and other axis I diagnoses were assessed by the Diagnostic Interview Schedule. Data on risk factors were collected by a specially constructed interview schedule. The lifetime prevalence of PTSD was 29.6% (24.3% for males and 45.3% for females), and the current prevalence was 19.2% (12.2% for males and 40.0% for females). These prevalences reflect a high occurrence of traumatic exposures and a high case rate among those who experienced trauma. The risk of PTSD varied with the nature of the trauma, the number of traumas experienced, psychiatric comorbidity, and familial characteristics. The higher rate of PTSD among females was due to a greater frequency of rape, which carries a high risk of PTSD development, and to a high rate of comorbid conditions. The lifetime prevalence of PTSD among these chemically dependent adolescents is five times that reported for a community sample of adolescents. This extremely high rate provides new understanding of the etiologic connection between PTSD and chemical dependence and has implications for their treatment. JF - The American journal of psychiatry AU - Deykin, E Y AU - Buka, S L AD - Department of Psychiatry, Harvard Medical School, Boston, USA. Deykin.Eva_Y@Boston.VA.-Gov or Dandeykin@aol.com Y1 - 1997/06// PY - 1997 DA - June 1997 SP - 752 EP - 757 VL - 154 IS - 6 SN - 0002-953X, 0002-953X KW - Abridged Index Medicus KW - Index Medicus KW - Age Factors KW - Sex Factors KW - Rape -- statistics & numerical data KW - Humans KW - Mental Disorders -- epidemiology KW - Comorbidity KW - Life Change Events KW - Risk Factors KW - Adult KW - Family KW - Adolescent KW - Female KW - Male KW - Prevalence KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Stress Disorders, Post-Traumatic -- psychology KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79025922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Prevalence+and+risk+factors+for+posttraumatic+stress+disorder+among+chemically+dependent+adolescents.&rft.au=Deykin%2C+E+Y%3BBuka%2C+S+L&rft.aulast=Deykin&rft.aufirst=E&rft.date=1997-06-01&rft.volume=154&rft.issue=6&rft.spage=752&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-06-18 N1 - Date created - 1997-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A phase II study of topotecan in patients with recurrent head and neck cancer. Identification of an active new agent. AN - 79013907; 9167758 AB - This study evaluated the efficacy and safety of topotecan, a topoisomerase I inhibitor, in patients with advanced squamous cell cancer of the head and neck. Topotecan was administered intravenously (over 30 min) daily for 5 days every 3 weeks at a starting dose of 1.5 mg/m2/day. Eligibility required no prior chemotherapy, measurable disease, and performance status of < or = 2. Quality of life (QOL) assessment was performed at specified time points using the Spitzer QOL index and the symptom distress scale. Of 26 patients entered into the study, 23 and 22 patients were assessable for toxicity and response, respectively. One complete and two partial responses were observed, with response durations of 9, 4, and 1.5 months, respectively. Six patients had stable disease, including one patient with a 45% tumor shrinkage. The median survival for all patients entered was 4 months. Neutropenia was the major dose-limiting side effect, with grade 4 toxicity observed in 42% of all cycles of treatment. Grade 3 anemia occurred in 16% of all cycles, and nine patients required blood transfusions. Nonhematologic toxicities were infrequent and mild to moderate. QOL assessment revealed no significant change of total scores between each assessment point. Topotecan is a well-tolerated new agent with similar single-agent activity to that of cisplatin, 5-fluorouracil, and methotrexate in advanced head and neck cancer. Further investigation of this agent with other chemotherapeutic drugs and with concurrent radiation therapy is appropriate. JF - American journal of clinical oncology AU - Robert, F AU - Soong, S J AU - Wheeler, R H AD - Birmingham Veterans Administration Medical Center, Alabama, USA. Y1 - 1997/06// PY - 1997 DA - June 1997 SP - 298 EP - 302 VL - 20 IS - 3 SN - 0277-3732, 0277-3732 KW - Antineoplastic Agents KW - 0 KW - Topotecan KW - 7M7YKX2N15 KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Neoplasm Staging KW - Humans KW - Anemia -- chemically induced KW - Adult KW - Quality of Life KW - Neutropenia -- chemically induced KW - Aged KW - Middle Aged KW - Male KW - Female KW - Survival Analysis KW - Remission Induction KW - Neoplasm Recurrence, Local -- drug therapy KW - Camptothecin -- analogs & derivatives KW - Camptothecin -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Head and Neck Neoplasms -- drug therapy KW - Carcinoma, Squamous Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79013907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+clinical+oncology&rft.atitle=A+phase+II+study+of+topotecan+in+patients+with+recurrent+head+and+neck+cancer.+Identification+of+an+active+new+agent.&rft.au=Robert%2C+F%3BSoong%2C+S+J%3BWheeler%2C+R+H&rft.aulast=Robert&rft.aufirst=F&rft.date=1997-06-01&rft.volume=20&rft.issue=3&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=American+journal+of+clinical+oncology&rft.issn=02773732&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-06-26 N1 - Date created - 1997-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - End-of-Life Decisionmaking in the Veterans Health Administration AN - 61435334; 9810378 AB - Three case studies that came before the Consultation Service of the Ethics Advisory Committee at the New York Dept of Veterans Affairs Medical Center are used to illustrate the influence of Veterans Health Administration ethics policies regarding withholding or withdrawal of life-sustaining treatment, do-not-resuscitate protocols, & informed consent on end-of-life decision making. The studies illustrate that the administration tends to use a preponderance of evidence standard to determine patients' wishes in cases where the patients lack decisional capacity, but also allows a best interest line of reasoning in the absence of clear evidence. Veterns Health Administration procedures concerning acceptable surrogate decisionmakers also are outlined. Although the administration allows terminally ill patients to decide when life-sustaining treatment should be withheld or withdrawn, its policy does not allow physician-assisted suicide. 19 References. Adapted from the source document. JF - HEC Forum AU - Berkowitz, Kenneth A AD - Medical Service New York Veterans Administration Medical Center, NY 10010 Y1 - 1997/06// PY - 1997 DA - June 1997 SP - 169 EP - 181 VL - 9 IS - 2 SN - 0956-2737, 0956-2737 KW - Veterans KW - Bioethics KW - Informed Consent KW - Termination of Treatment KW - Euthanasia KW - Medical Decision Making KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61435334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=HEC+Forum&rft.atitle=End-of-Life+Decisionmaking+in+the+Veterans+Health+Administration&rft.au=Berkowitz%2C+Kenneth+A&rft.aulast=Berkowitz&rft.aufirst=Kenneth&rft.date=1997-06-01&rft.volume=9&rft.issue=2&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=HEC+Forum&rft.issn=09562737&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - HEFOE8 N1 - SubjectsTermNotLitGenreText - Veterans; Medical Decision Making; Termination of Treatment; Informed Consent; Euthanasia; Bioethics ER - TY - JOUR T1 - The Efficacy of Computer-Provided Reading Treatment for Chronic Aphasic Adults AN - 58377679; 9807779 AB - The language performance of chronic aphasic subjects ([Ss] N = 63, aged 48-83) was examined for change over time resulting from a computer reading treatment. Ss were divided into a computer reading treatment group, a computer stimulation group, & a no-treatment group. The computer stimulation group was used to evaluate the effect of computer stimulation alone on language performance. The custom-designed software used in the computer reading treatment condition consisted of word & letter matching activities & reading comprehension activities. The computer stimulation software consisted of games & cognitive rehabilitation software that did not overtly require the use of language abilities. The Porch Index of Communicative Ability & the Western Aphasia Battery were used to establish baseline language performance at entry & at 3- & 6-month intervals. Data suggested that language improvement resulted from the language content of the software & not just computer stimulation. This computer reading treatment was found to be efficacious for the treatment of aphasia. 5 Tables, 7 Figures, 60 References. D. Taylor JF - Journal of Speech, Language, and Hearing Research AU - Katz, Richard C AU - Wertz, Robert T AD - Audiology & Speech Pathology Veterans Affairs Medical Center, 650 East Indian School Road Phoenix AZ 85012-1892 katz.richard@phoenix.va.gov Y1 - 1997/06// PY - 1997 DA - June 1997 SP - 493 EP - 507 VL - 40 IS - 3 SN - 1092-4388, 1092-4388 KW - Computer Software (14360) KW - Aphasia (03400) KW - Computer Applications (14150) KW - Remedial Reading (72900) KW - Adults (00600) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58377679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=The+Efficacy+of+Computer-Provided+Reading+Treatment+for+Chronic+Aphasic+Adults&rft.au=Katz%2C+Richard+C%3BWertz%2C+Robert+T&rft.aulast=Katz&rft.aufirst=Richard&rft.date=1997-06-01&rft.volume=40&rft.issue=3&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Adults (00600); Computer Applications (14150); Computer Software (14360); Remedial Reading (72900) ER - TY - JOUR T1 - Is the Addiction Severity Index a Reliable and Valid Assessment Instrument among Clients with Severe and Persistent Mental Illness and Substance Abuse Disorders? AN - 1761704345; 199703972 AB - A total of 62 clients with a severe & persistent mental illness & concurrent substance abuse disorders, enrolled in a publicly funded community mental health center, volunteered to participate in an interobserver & test-retest reliability study of the Addiction Severity Index. Spearman-Brown & Pearson correlation coefficients were calculated to examine the extent of agreement among client responses. As a whole, the interobserver reliability of the composite index scores was satisfactory. However, there was more variance in the stability of client responses, with four composite scores producing test-retest reliability coefficients below .65. Findings suggest that the index has a number of limitations in assessing the problems of clients with severe & persistent mental illness; however, it is likely that other similar instruments would also encounter these limitations. 2 Tables, 18 References. Adapted from the source document. JF - Community Mental Health Journal AU - Zanis, David A AU - McLellan, A Thomas AU - Corse, Sara AD - Philadelphia Veterans Administration Medical Center, Bldg #7 Mail Code 116-D University & Woodland Aves PA 19104 Y1 - 1997/06// PY - 1997 DA - June 1997 SP - 213 EP - 227 VL - 33 IS - 3 SN - 0010-3853, 0010-3853 KW - clients with severe mental illness/subtance abuse disorder, addiction severity index reliability/validity KW - volunteer test data KW - Drug Addiction KW - Diagnosis KW - Indexes (Measures) KW - Community Mental Health Centers KW - Mental Illness KW - article KW - 6129: addiction KW - 6142: mental & emotional problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761704345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=Is+the+Addiction+Severity+Index+a+Reliable+and+Valid+Assessment+Instrument+among+Clients+with+Severe+and+Persistent+Mental+Illness+and+Substance+Abuse+Disorders%3F&rft.au=Zanis%2C+David+A%3BMcLellan%2C+A+Thomas%3BCorse%2C+Sara&rft.aulast=Zanis&rft.aufirst=David&rft.date=1997-06-01&rft.volume=33&rft.issue=3&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Diagnosis; Mental Illness; Drug Addiction; Indexes (Measures); Community Mental Health Centers ER - TY - JOUR T1 - Interferon-gamma is necessary for the expression of hypersensitivity pneumonitis. AN - 79002203; 9153280 AB - Farmers lung disease is a common form of hypersensitivity pneumonitis (HP) and is characterized by inflammation and granuloma formation in the lung. Interferon-gamma is important for the expression of granulomatous diseases caused by infectious agents; however, the role this mediator in regulating expression of the granulomatous response to inhaled antigen is not known. To evaluate this, we compared the response to inhaled antigen of mice that do not express the gene coding for interferon-gamma (GKO) with that of their normal littermates (WT). GKO and WT mice on a BALB/c background were exposed to 150 microg of the thermophilic bacteria Saccharopolyspora rectivirgula or saline alone, for three consecutive days a week, for 3 wk. After exposure to antigen, WT mice developed a marked granulomatous inflammation associated with an increase in lung weight and numbers of cells in bronchoalveolar lavage fluid (BAL). Although GKO mice also exhibited an increase in lung weight and numbers of cells in BAL fluid, they developed minimal inflammation and no granulomas after a similar exposure to antigen. To further evaluate if the lack of a response to antigen in GKO mice was due to lack of IFN-gamma, we replaced this mediator via intraperitoneal injections. When given replacement IFN-gamma, the GKO mice developed granulomatous inflammation in the lung. These studies show that IFN-gamma is essential for the expression of hypersensitivity pneumonitis. JF - The Journal of clinical investigation AU - Gudmundsson, G AU - Hunninghake, G W AD - University of Iowa College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242, USA. gunnar-gudmundsson@uiowa.edu Y1 - 1997/05/15/ PY - 1997 DA - 1997 May 15 SP - 2386 EP - 2390 VL - 99 IS - 10 SN - 0021-9738, 0021-9738 KW - Antigens, Bacterial KW - 0 KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Alveolitis, Extrinsic Allergic -- therapy KW - Animals KW - Reference Values KW - Exons KW - Immunotherapy KW - Alveolitis, Extrinsic Allergic -- immunology KW - Mice KW - Mice, Inbred BALB C KW - Alveolitis, Extrinsic Allergic -- pathology KW - Organ Size KW - Mice, Knockout KW - Inflammation KW - Body Weight KW - Bronchoalveolar Lavage Fluid -- cytology KW - Farmer's Lung -- immunology KW - Female KW - Interferon-gamma -- genetics KW - Interferon-gamma -- therapeutic use KW - Interferon-gamma -- deficiency KW - Interferon-gamma -- physiology KW - Antigens, Bacterial -- immunology KW - Lung -- pathology KW - Lung -- physiopathology KW - Saccharopolyspora -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79002203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Interferon-gamma+is+necessary+for+the+expression+of+hypersensitivity+pneumonitis.&rft.au=Gudmundsson%2C+G%3BHunninghake%2C+G+W&rft.aulast=Gudmundsson&rft.aufirst=G&rft.date=1997-05-15&rft.volume=99&rft.issue=10&rft.spage=2386&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-06-17 N1 - Date created - 1997-06-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1991 Oct 11;254(5029):279-82 [1681588] Science. 1991 Oct 11;254(5029):277-9 [1925582] Am J Respir Cell Mol Biol. 1992 Feb;6(2):183-9 [1540381] Clin Chest Med. 1992 Jun;13(2):303-9 [1511555] Clin Chest Med. 1992 Jun;13(2):311-28 [1511556] Clin Exp Allergy. 1992 Aug;22(8):783-92 [1525698] Radiol Clin North Am. 1992 Nov;30(6):1219-30 [1410310] Am Rev Respir Dis. 1992 Aug;146(2):479-84 [1489144] Chest. 1993 Feb;103(2 Suppl):139S-143S [8094047] Chest. 1993 Feb;103(2 Suppl):145S [8428542] Science. 1993 Mar 19;259(5102):1739-42 [8456300] Int Arch Allergy Immunol. 1993;101(1):47-51 [8499773] J Exp Med. 1993 Oct 1;178(4):1435-40 [8376946] J Exp Med. 1993 Dec 1;178(6):2243-7 [8245795] J Exp Med. 1993 Dec 1;178(6):2249-54 [7504064] Respir Med. 1993 Oct;87(7):495-501 [8265836] West J Med. 1993 Nov;159(5):570-8 [8279154] Exp Lung Res. 1993 Nov-Dec;19(6):631-52 [8281911] Eur Respir J. 1993 Oct;6(9):1276-81 [8287943] Biochemistry. 1979 Nov 27;18(24):5294-9 [518835] Immunology. 1981 Mar;42(3):409-17 [7203528] J Clin Immunol. 1982 Jan;2(1):46-54 [6212593] J Immunol. 1982 Nov;129(5):2160-3 [6811659] J Immunol. 1986 Apr 1;136(7):2348-57 [2419430] Thorax. 1986 Jan;41(1):28-33 [3704964] Exp Pathol. 1986;29(2):95-102 [3486777] Am J Respir Crit Care Med. 1994 Apr;149(4 Pt 1):989-93 [8143065] J Exp Med. 1994 Apr 1;179(4):1367-71 [7908325] J Allergy Clin Immunol. 1994 Aug;94(2 Pt 2):304-9 [8077583] Am J Respir Crit Care Med. 1994 Oct;150(4):1038-48 [7921434] Semin Respir Infect. 1995 Jun;10(2):96-106 [7569404] J Allergy Clin Immunol. 1996 Apr;97(4):1027-30 [8655880] J Allergy Clin Immunol. 1988 Feb;81(2):391-400 [3339196] J Immunol. 1988 Jun 15;140(12):4245-52 [2967332] Science. 1990 Jun 8;248(4960):1230-4 [2161559] J Immunol. 1990 Jun 15;144(12):4651-6 [1972164] Am J Respir Cell Mol Biol. 1992 Jan;6(1):68-74 [1728297] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structural determinants for agonist binding affinity to thromboxane/prostaglandin endoperoxide (TP) receptors. Analysis of chimeric rat/human TP receptors. AN - 78998966; 9139686 AB - The two most extensively characterized thromboxane/prostaglandin endoperoxide (TP) receptors, from human platelets and rat vascular smooth muscle, exhibit thromboxane agonist [15-(1alpha,2beta(5Z), 3alpha-(1E,3S), 4alpha)]-7-[3-hydroxy-4-(p-iodophenoxy)-1-butenyl-7-oxabi cyclohepteno ic acid (I-BOP) binding affinities that differ by an order of magnitude, rat TP having the higher affinity. We utilized this difference in I-BOP affinity to identify structural determinants of TP receptor heterogeneity. No significant difference was found in the rank order of affinities for a series of thromboxane receptor ligands to bind to cloned human TPalpha versus rat TP, indicating that these represent species homologs, not distinct TP subtypes. Structural determinants for observed differences in I-BOP binding Kd were localized by creating chimeric human/rat TP followed by mutational substitution of specific critical amino acids. Initially, seven chimeric receptors with splice sites in transmembranes 1, 2, 4, or 7 were constructed and expressed in HEK293 cells for analysis of ligand binding properties. Substitution of any part except the carboxyl tail of the human TP into the rat TP resulted in a receptor with I-BOP binding affinity intermediate between the two. Analysis of chimeras in which only the extracellular amino terminus and a portion of transmembrane 1 were switched localized the determinant of high affinity binding to the region between amino acids 3 and 40. Using this chimera, amino acids in the human portion (extracellular amino terminus and part of transmembrane 1) were replaced with analogous amino acids from rat TP to regain high affinity I-BOP binding. Only when amino acid Val37 and either Val36 or Ala40 were reverted to their respective rat TP counterparts (Ala36, Leu37, and Gly40, respectively) was high affinity I-BOP binding recovered. The mechanism for the increased I-BOP affinity may be the lengthening of the amino acid side chain at position 37, thus extending this group further into the putative I-BOP binding pocket, with compensatory shortening of side chains in spatially adjacent amino acids. JF - The Journal of biological chemistry AU - Dorn, G W AU - Davis, M G AU - D'Angelo, D D AD - University of Cincinnati and the Cincinnati Veterans Administration Medical Center, Cincinnati, Ohio 45267-0542, USA. Y1 - 1997/05/09/ PY - 1997 DA - 1997 May 09 SP - 12399 EP - 12405 VL - 272 IS - 19 SN - 0021-9258, 0021-9258 KW - Bridged Bicyclo Compounds, Heterocyclic KW - 0 KW - Fatty Acids, Unsaturated KW - Hydrazines KW - Receptors, Prostaglandin KW - Receptors, Thromboxane KW - Recombinant Fusion Proteins KW - prostaglandin endoperoxide receptor KW - 7-(3-(3-hydroxy-4-(4'-iodophenoxy)-1-butenyl)-7-oxabicyclo(2.2.1)heptan-2-yl)-5-heptenoic acid KW - 124924-85-2 KW - SQ 29548 KW - 98299-61-7 KW - Index Medicus KW - Rats KW - Mutagenesis, Site-Directed KW - Animals KW - Fatty Acids, Unsaturated -- metabolism KW - Models, Molecular KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Bridged Bicyclo Compounds, Heterocyclic -- metabolism KW - Hydrazines -- metabolism KW - Structure-Activity Relationship KW - Recombinant Fusion Proteins -- metabolism KW - Receptors, Prostaglandin -- metabolism KW - Receptors, Prostaglandin -- chemistry KW - Receptors, Thromboxane -- metabolism KW - Receptors, Thromboxane -- chemistry KW - Recombinant Fusion Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78998966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Structural+determinants+for+agonist+binding+affinity+to+thromboxane%2Fprostaglandin+endoperoxide+%28TP%29+receptors.+Analysis+of+chimeric+rat%2Fhuman+TP+receptors.&rft.au=Dorn%2C+G+W%3BDavis%2C+M+G%3BD%27Angelo%2C+D+D&rft.aulast=Dorn&rft.aufirst=G&rft.date=1997-05-09&rft.volume=272&rft.issue=19&rft.spage=12399&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-06-16 N1 - Date created - 1997-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CO2 provocation of panic: symptomatic and manometric evaluation in patients with noncardiac chest pain. AN - 85232910; pmid-9149197 AB - OBJECTIVES: Occult panic disorder (PD) may underlie 10-43% of chest pain syndromes in patients with normal coronary arteries. A variety of agents, such as intravenous lactate, oral caffeine, and inhaled CO2, has been identified that may provoke panic attacks in susceptible patients. The aims of this study were (1) to better define the relationship between noncardiac chest pain syndromes and panic disorder; and (2) to assess the diagnostic utility of PD provocative testing with inhaled CO2 in eliciting chest pain and/or esophageal manometric disturbances. METHODS: Fourteen patients with chest pain syndromes and negative coronary angiograms or stress thallium tests were evaluated for PD and underwent (1) standard esophageal manometry followed by continuous manometric recording; (2) inhalation by face mask of room air or 35% CO2, single blinded, in random order; (3) a previously validated Acute Panic Inventory questionnaire administered before and immediately after each inhalation; and (4) Tensilon 10 mg i.v. administration. RESULTS: Of 14 patients, 8 met DSM-IIIR criteria for panic disorder. Mean Acute Panic Inventory scores (reflecting panic symptoms) increased significantly after CO2 inhalation relative to room air in all patients. Of 14 patients, 8 (4 PD, 4 non-PD) experienced chest pain after CO2 inhalation, whereas no patient had chest pain after room air inhalation. Of 14 patients, 5 had pain with Tensilon (4 of 5 whom responded to CO2). No specific manometric abnormalities occurred during any chest pain episode. CONCLUSION: CO2 inhalation is as effective as Tensilon in provoking chest pain in patients with noncardiac chest pain. The high prevalence of PD in such patients suggests that CO2 inhalation, a known panicogen, may be useful in evaluating such patients. The mechanism of CO2 induced chest pain remains unknown, but does not appear to be attributable to demonstrable esophageal motility abnormalities. JF - The American Journal of Gastroenterology AU - Stollman, N H AU - Bierman, P S AU - Ribeiro, A AU - Rogers, A I AU - Ribiero, A AD - University of Miami School of Medicine and Veterans Administration Medical Center, Florida, USA. PY - 1997 SP - 839 EP - 842 VL - 92 IS - 5 SN - 0002-9270, 0002-9270 KW - Esophagus KW - Diagnosis, Differential KW - Human KW - Aged KW - Predictive Value of Tests KW - Chest Pain KW - Esophageal Motility Disorders KW - Panic Disorder KW - Adult KW - Support, Non-U.S. Gov't KW - Middle Age KW - Manometry KW - Administration, Inhalation KW - Male KW - Female KW - Carbon Dioxide KW - Psychological Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85232910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=CO2+provocation+of+panic%3A+symptomatic+and+manometric+evaluation+in+patients+with+noncardiac+chest+pain.&rft.au=Stollman%2C+N+H%3BBierman%2C+P+S%3BRibeiro%2C+A%3BRogers%2C+A+I%3BRibiero%2C+A&rft.aulast=Stollman&rft.aufirst=N&rft.date=1997-05-01&rft.volume=92&rft.issue=5&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Mucosa-associated lymphoid tissue (MALT) in Barrett's esophagus: prospective evaluation and association with gastric MALT, MALT lymphoma, and Helicobacter pylori. AN - 85231235; pmid-9149188 AB - OBJECTIVES: Prospective evaluation of the prevalence of mucosa-associated lymphoid tissue (MALT) within Barrett's esophagus and its association with gastric MALT, gastric MALT lymphoma, and H. pylori infection. METHODS: From Barrett's esophagus patients, a minimum of six gastric biopsies were obtained, in addition to Barrett's surveillance biopsies. Additional gastric biopsies were taken from any ulcer(s), nodule(s), polyp(s), or other lesions. Patients with gastroesophageal reflux symptoms without Barrett's esophagus served as controls. RESULTS: One hundred and thirty-nine Barrett's patients were included in the study. One hundred and twenty-two of these patients had gastric biopsies for gastric MALT and H. pylori determination. H. pylori was noted in the stomach of 48 patients and within Barrett's mucosa in 14. Barrett's MALT was noted in seven cases, gastric MALT in 16, and gastric MALT lymphoma in two. None of the 101 control patients had esophageal MALT. Two of the seven patients with Barrett's MALT had gastric MALT. Barrett's MALT was associated with esophageal H. pylori in 57.1% cases and gastric H. pylori in 71.4%. The prevalence of gastric and esophageal H. pylori in patients with Barrett's MALT was significantly higher compared to patients with Barrett's without MALT (p < 0.0001 and p < 0.007, respectively). Barrett's MALT was very focal and its esophageal location variable. CONCLUSIONS: Barrett's MALT was associated with both esophageal and gastric H. pylori colonization. Esophageal MALT was associated with Barrett's esophagus. Gastric biopsy sampling is warranted in any patient with Barrett's MALT to detect gastric MALT and H. pylori, which, if found, should be eradicated. JF - The American Journal of Gastroenterology AU - Weston, A P AU - Cherian, R AU - Horvat, R T AU - Lawrinenko, V AU - Dixon, A AU - McGregor, D AD - Veterans Administration Medical Center, Kansas City, Missouri 64128, USA. PY - 1997 SP - 800 EP - 804 VL - 92 IS - 5 SN - 0002-9270, 0002-9270 KW - Prospective Studies KW - Lymphoma, Mucosa-Associated Lymphoid Tissue KW - Human KW - Adult KW - Middle Age KW - Support, U.S. Gov't, Non-P.H.S. KW - Aged KW - Barrett Esophagus KW - Helicobacter Infections KW - Stomach KW - Male KW - Female KW - Prevalence KW - Helicobacter pylori UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85231235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Mucosa-associated+lymphoid+tissue+%28MALT%29+in+Barrett%27s+esophagus%3A+prospective+evaluation+and+association+with+gastric+MALT%2C+MALT+lymphoma%2C+and+Helicobacter+pylori.&rft.au=Weston%2C+A+P%3BCherian%2C+R%3BHorvat%2C+R+T%3BLawrinenko%2C+V%3BDixon%2C+A%3BMcGregor%2C+D&rft.aulast=Weston&rft.aufirst=A&rft.date=1997-05-01&rft.volume=92&rft.issue=5&rft.spage=800&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Complexity of the outward K+ current of the rat megakaryocyte. AN - 79044940; 9176143 AB - Megakaryocytes isolated from rat bone marrow express a voltage-dependent, outward K+ current with complex kinetics of activation and inactivation. We found that this current could be separated into at least two components based on differential responses to K+ channel blockers. One component, which exhibited features of the "transient" or "A-type" K+ current of excitable cells, was more strongly blocked by 4-aminopyridine (4-AP) than by tetrabutylammonium (TBA). This current, which we designated as "4-AP-sensitive" current, activated rapidly at potentials more positive than -40 mV and subsequently underwent rapid voltage-dependent inactivation. A separate current that activated slowly was blocked much more effectively by TBA than by 4-AP. This "TBA-sensitive" component, which resembled a typical delayed rectifier current, was much more resistant to voltage-dependent inactivation. The relative contribution of each of these components varied from cell to cell. The effect of charybdotoxin was similar to that of 4-AP. Our data indicate that the voltage-dependent K+ current of resting megakaryocytes is more complex than heretofore believed and support the emerging concept that megakaryocytes possess intricate electrophysiological properties. JF - The American journal of physiology AU - Romero, E AU - Sullivan, R AD - Medical Service, Veterans Administration Medical Center, Houston, Texas, USA. Y1 - 1997/05// PY - 1997 DA - May 1997 SP - C1525 EP - C1531 VL - 272 IS - 5 Pt 1 SN - 0002-9513, 0002-9513 KW - Potassium Channels KW - 0 KW - Quaternary Ammonium Compounds KW - Charybdotoxin KW - 115422-61-2 KW - 4-Aminopyridine KW - BH3B64OKL9 KW - tetrabutylammonium KW - CBU2X6BBJR KW - Index Medicus KW - Rats KW - Animals KW - Electric Conductivity KW - 4-Aminopyridine -- pharmacology KW - Kinetics KW - Rats, Wistar KW - Electrophysiology KW - Quaternary Ammonium Compounds -- pharmacology KW - Charybdotoxin -- pharmacology KW - Potassium Channels -- classification KW - Megakaryocytes -- physiology KW - Potassium Channels -- physiology KW - Potassium Channels -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79044940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Complexity+of+the+outward+K%2B+current+of+the+rat+megakaryocyte.&rft.au=Romero%2C+E%3BSullivan%2C+R&rft.aulast=Romero&rft.aufirst=E&rft.date=1997-05-01&rft.volume=272&rft.issue=5+Pt+1&rft.spage=C1525&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-07-08 N1 - Date created - 1997-07-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Myosin light chain kinase in endothelium: molecular cloning and regulation. AN - 79028987; 9160829 AB - The phosphorylation of myosin light chains by myosin light chain kinase (MLCK) is a key event in agonist-mediated endothelial cell gap formation and vascular permeability. We now report the cloning and expression of a nonmuscle MLCK isoform in cultured endothelium. Screening of a human endothelial cell cDNA library identified a 7.7 kb cDNA with substantial (> 95%) homology to the coding region of the rabbit and bovine smooth muscle (SM) MLCK (amino acid #923-1913) as well as with the reported avian nonmuscle MLCK (65-70% homology). Sequence analysis also identified, however, a 5' stretch of novel sequence (amino acids #1-922) which is not contained in the open reading frame of mammalian SM MLCK, and is only 58% homologous to the avian fibroblast MLCK sequence. Immunoprecipitation with NH2-specific antisera revealed a 214 kD high molecular weight MLCK in bovine and human endothelium which exhibits MLC phosphorylation properties. Amino acid sequence analysis revealed endothelial MLCK consensus sequences for a variety of protein kinases including highly conserved potential phosphorylation sites for cAMP-dependent protein kinase A (PKA) in the CaM-binding region. Augmentation of intracellular cAMP levels markedly enhanced MLCK phosphorylation (2.5-fold increase) and reduced kinase activity in MLCK immunoprecipitates (4-fold decrease). These data suggest potentially novel mechanisms of endothelial cell contraction and barrier regulation. JF - American journal of respiratory cell and molecular biology AU - Garcia, J G AU - Lazar, V AU - Gilbert-McClain, L I AU - Gallagher, P J AU - Verin, A D AD - Department of Medicine, Indiana University School of Medicine, and Richard Roudebush Veterans Administration Center, Indianapolis, USA. Y1 - 1997/05// PY - 1997 DA - May 1997 SP - 489 EP - 494 VL - 16 IS - 5 SN - 1044-1549, 1044-1549 KW - DNA, Complementary KW - 0 KW - Cholera Toxin KW - 9012-63-9 KW - Cyclic AMP KW - E0399OZS9N KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - Myosin-Light-Chain Kinase KW - EC 2.7.11.18 KW - Index Medicus KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - Animals KW - DNA, Complementary -- genetics KW - Enzyme Activation KW - Humans KW - Cholera Toxin -- pharmacology KW - Amino Acid Sequence KW - Molecular Weight KW - Cloning, Molecular KW - Pulmonary Artery KW - Cattle KW - Phosphorylation KW - Cells, Cultured KW - Umbilical Veins KW - Cyclic AMP -- metabolism KW - Molecular Sequence Data KW - Sequence Homology, Amino Acid KW - Species Specificity KW - Myosin-Light-Chain Kinase -- chemistry KW - Myosin-Light-Chain Kinase -- metabolism KW - Endothelium, Vascular -- enzymology KW - Myosin-Light-Chain Kinase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79028987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Myosin+light+chain+kinase+in+endothelium%3A+molecular+cloning+and+regulation.&rft.au=Garcia%2C+J+G%3BLazar%2C+V%3BGilbert-McClain%2C+L+I%3BGallagher%2C+P+J%3BVerin%2C+A+D&rft.aulast=Garcia&rft.aufirst=J&rft.date=1997-05-01&rft.volume=16&rft.issue=5&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-06-17 N1 - Date created - 1997-06-17 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - U48959; GENBANK N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men. AN - 78958423; 9131844 AB - Relapsed alcoholic individuals frequently report that negative emotional states trigger their return to drinking. A parametric laboratory study was conducted to assess the separate and combined effects of exposure to alcohol-related stimuli and induced negative moods in abstinent alcoholic persons. The authors also sought to determine if reactivity to alcohol cues or reactivity to negative mood induction predicted relapse soon after treatment. Men with alcoholism (N = 50) undergoing inpatient treatment participated in a guided imagery procedure designed to induce negative moods and were then exposed to either their favorite alcoholic beverage or to spring water. Results indicated that both alcoholic beverage presentation and negative affect imagery led to increased subjective reporting of desire to drink. These effects were additive but not multiplicative (i.e., the interaction of mood state with beverage type was not significant). Reported urge to drink during the trial that combined negative mood imagery with alcoholic beverage exposure predicted time to relapse after inpatient discharge. JF - Journal of abnormal psychology AU - Cooney, N L AU - Litt, M D AU - Morse, P A AU - Bauer, L O AU - Gaupp, L AD - Psychology Service, VA Connecticut Healthcare System, West Haven 06516, USA. cooney.ned@west-haven.va.gov Y1 - 1997/05// PY - 1997 DA - May 1997 SP - 243 EP - 250 VL - 106 IS - 2 SN - 0021-843X, 0021-843X KW - Index Medicus KW - Motivation KW - Humans KW - Adult KW - Alcohol Drinking -- psychology KW - Middle Aged KW - Alcohol Drinking -- prevention & control KW - Recurrence KW - Male KW - Alcoholism -- rehabilitation KW - Arousal KW - Depression -- psychology KW - Cues KW - Alcoholic Beverages KW - Depression -- diagnosis KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78958423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+abnormal+psychology&rft.atitle=Alcohol+cue+reactivity%2C+negative-mood+reactivity%2C+and+relapse+in+treated+alcoholic+men.&rft.au=Cooney%2C+N+L%3BLitt%2C+M+D%3BMorse%2C+P+A%3BBauer%2C+L+O%3BGaupp%2C+L&rft.aulast=Cooney&rft.aufirst=N&rft.date=1997-05-01&rft.volume=106&rft.issue=2&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Journal+of+abnormal+psychology&rft.issn=0021843X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-06-12 N1 - Date created - 1997-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - C2 region-derived peptides of beta-protein kinase C regulate cardiac Ca2+ channels. AN - 78948057; 9130453 AB - We have previously shown that alpha1-adrenergic activation inhibited beta-adrenergic-stimulated L-type Ca2+ current (I(Ca)). To determine the role of protein kinase C (PKC) in this regulation, the inositol trisphosphate pathway was bypassed by direct activation of PKC with 4beta-phorbol 12-myristate 13-acetate (PMA). To minimize Ca2+-induced Ca2+ inactivation, Ba2+ current (I(Ba)) was recorded through Ca2+ channels in adult rat ventricular myocytes. We found that PMA (0.1 micromol/L) consistently inhibited basal I(Ba) by 40.5+/-7.4% and isoproterenol (ISO, 0.1 micromol/L)-stimulated I(Ba) by 48.9+/-7.8%. These inhibitory effects were not observed with the inactive phorbol ester analogue alpha-phorbol 12,13-didecanoate (0.1 micromol/L). To identify the PKC isozymes that mediate these PMA effects, we intracellularly applied peptide inhibitors of a subclass of PKC isozymes, the C2-containing cPKCs. These peptides (betaC2-2 and betaC2-4) specifically inhibit the translocation and function of C2-containing isozymes (alpha-PKC, betaI-PKC, and betaII-PKC), but not the C2-less isozymes (delta-PKC and epsilon-PKC). We first used the pseudosubstrate peptide (0.1 micromol/L in the pipette), which inhibits the catalytic activity of all the PKC isozymes, and found that PMA-induced inhibition of ISO-stimulated I(Ba) was reduced to 16.8+/-7.4% but was not affected by the scrambled pseudosubstrate peptide. The effects of PMA on basal and ISO-stimulated I(Ba) were then determined in the presence of C2-derived peptides or control peptides. When the pipette contained 0.1 micromol/L of betaC2-2 or betaC2-4, PMA-induced inhibition of basal I(Ba) was 26.1+/-4.5% and 23.6+/-2.2%, respectively. Similarly, ISO-stimulated I(Ba) was inhibited by 29.9+/-6.6% and 29.3+/-7.8% in the presence of betaC2-2 and betaC2-4, respectively. In contrast, there was no significant change in the effect of PMA in the presence of control peptides, scrambled betaC2-4, or pentalysine. Finally, PMA-induced inhibition of basal and ISO-stimulated I(Ba) was almost completely abolished in cells dialyzed with both betaC2-2 and betaC2-4. Together, these data suggest a role for C2-containing isozymes in mediating PMA-induced inhibition of L-type Ca2+ channel activity. JF - Circulation research AU - Zhang, Z H AU - Johnson, J A AU - Chen, L AU - El-Sherif, N AU - Mochly-Rosen, D AU - Boutjdir, M AD - Department of Medicine, State University of New York, Health Science Center, and the Veterans Administration Medical Center, Brooklyn 11209, USA. Y1 - 1997/05// PY - 1997 DA - May 1997 SP - 720 EP - 729 VL - 80 IS - 5 SN - 0009-7330, 0009-7330 KW - Adrenergic beta-Agonists KW - 0 KW - Calcium Channels KW - Dihydropyridines KW - Isoenzymes KW - Peptides KW - Receptors, Adrenergic KW - Protein Kinase C KW - EC 2.7.11.13 KW - Isoproterenol KW - L628TT009W KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Dihydropyridines -- pharmacology KW - Amino Acid Sequence KW - Receptors, Adrenergic -- physiology KW - Heart Ventricles -- cytology KW - Isoproterenol -- pharmacology KW - Stimulation, Chemical KW - Rats KW - Adrenergic beta-Agonists -- pharmacology KW - Blotting, Western KW - Patch-Clamp Techniques KW - In Vitro Techniques KW - Molecular Sequence Data KW - Rats, Wistar KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Isoenzymes -- antagonists & inhibitors KW - Protein Kinase C -- drug effects KW - Myocardium -- cytology KW - Protein Kinase C -- antagonists & inhibitors KW - Calcium Channels -- physiology KW - Calcium Channels -- metabolism KW - Isoenzymes -- physiology KW - Calcium Channels -- drug effects KW - Protein Kinase C -- physiology KW - Isoenzymes -- drug effects KW - Peptides -- physiology KW - Myocardium -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78948057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation+research&rft.atitle=C2+region-derived+peptides+of+beta-protein+kinase+C+regulate+cardiac+Ca2%2B+channels.&rft.au=Zhang%2C+Z+H%3BJohnson%2C+J+A%3BChen%2C+L%3BEl-Sherif%2C+N%3BMochly-Rosen%2C+D%3BBoutjdir%2C+M&rft.aulast=Zhang&rft.aufirst=Z&rft.date=1997-05-01&rft.volume=80&rft.issue=5&rft.spage=720&rft.isbn=&rft.btitle=&rft.title=Circulation+research&rft.issn=00097330&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-16 N1 - Date created - 1997-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) decreases glutamate uptake in cultured astrocytes. AN - 78942977; 9109551 AB - The deleterious effect of the parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on dopaminergic neurons of the substantia nigra is well established. In addition, increased glutamatergic drive to basal ganglia output nuclei is considered a likely contributor to the pathogenesis of Parkinson's disease. One possibility for the increased excitatory tone may be related to an impairment in glutamate uptake. As astrocytes possess efficient transport mechanisms for both MPTP and glutamate, we have examined the effect of this agent on D-aspartate uptake into these cells. Treatment of cultures with 50 microM MPTP for 24 h decreased uptake by 39%. Kinetic analysis revealed that this effect was due to a 35% decrease in Vmax with no change in the Km. Treatment with deprenyl, a monoamine oxidase B inhibitor, produced a complete reversal of MPTP-induced uptake inhibition, but was ineffective following exposure of cells to the MPTP metabolite, 1-methyl-4-phenylpyridinium (MPP+). Removal of MPTP from cultures resulted in a complete restoration of glutamate uptake after 24 h. These results show that MPTP reversibly compromises glutamate uptake in cultured astrocytes, which is dependent on the conversion of MPTP to MPP+. Such findings suggest that the glutamate transporter in astrocytes plays an important role in MPTP-induced neurotoxicity and possibly in parkinsonism. JF - Journal of neurochemistry AU - Hazell, A S AU - Itzhak, Y AU - Liu, H AU - Norenberg, M D AD - Veterans Administration Medical Center, Department of Pathology, University of Miami School of Medicine, Florida, U.S.A. Y1 - 1997/05// PY - 1997 DA - May 1997 SP - 2216 EP - 2219 VL - 68 IS - 5 SN - 0022-3042, 0022-3042 KW - Dopamine Agents KW - 0 KW - Glutamic Acid KW - 3KX376GY7L KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - 1-Methyl-4-phenylpyridinium KW - R865A5OY8J KW - Index Medicus KW - Rats KW - Osmolar Concentration KW - Animals KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - 1-Methyl-4-phenylpyridinium -- pharmacology KW - Glutamic Acid -- pharmacokinetics KW - Astrocytes -- drug effects KW - Dopamine Agents -- pharmacology KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine -- pharmacology KW - Astrocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78942977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=1-Methyl-4-phenyl-1%2C2%2C3%2C6-tetrahydropyridine+%28MPTP%29+decreases+glutamate+uptake+in+cultured+astrocytes.&rft.au=Hazell%2C+A+S%3BItzhak%2C+Y%3BLiu%2C+H%3BNorenberg%2C+M+D&rft.aulast=Hazell&rft.aufirst=A&rft.date=1997-05-01&rft.volume=68&rft.issue=5&rft.spage=2216&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-15 N1 - Date created - 1997-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma. AN - 78940558; 9108420 AB - Bacterial DNA and synthetic oligodeoxynucleotides containing the CpG motif (CpG ODN) can activate various immune cell subsets, including natural killer cells and macrophages. We evaluated whether the combination of CpG ODN and antitumor monoclonal antibody is effective at preventing tumor growth in an immunocompetent murine lymphoma model. CpG ODN-activated murine splenocytes induced lysis of tumor targets more effectively than unactivated splenocytes. These effector cells were also superior to unactivated splenocytes or cells activated with a control methylated ODN at inducing antibody-mediated lysis of 38C13 murine lymphoma cells. In vivo, CpG ODN alone had no effect on survival of mice inoculated with 38C13 cells. However, a single injection of CpG ODN enhanced the antitumor response to antitumor monoclonal antibody therapy. Ninety percent of mice treated with monoclonal antibody alone developed tumor compared with 20% of mice treated with antibody and CpG ODN. These antitumor effects were less pronounced when treatment consisted of an identical ODN containing methylated CpG dinucleotides. A single dose of CpG ODN appeared to be as effective as multiple doses of interleukin-2 at inhibiting tumor growth when combined with antitumor monoclonal antibody. We conclude that immunostimulatory CpG ODN can enhance antibody dependent cellular cytotoxicity and warrant further evaluation as potential immunotherapeutic reagents in cancer. JF - Blood AU - Wooldridge, J E AU - Ballas, Z AU - Krieg, A M AU - Weiner, G J AD - Iowa City Veterans Administration, the Department of Internal Medicine, The University of Iowa College of Medicine, USA. Y1 - 1997/04/15/ PY - 1997 DA - 1997 Apr 15 SP - 2994 EP - 2998 VL - 89 IS - 8 SN - 0006-4971, 0006-4971 KW - Adjuvants, Immunologic KW - 0 KW - Antibodies, Monoclonal KW - Antibodies, Neoplasm KW - Interleukin-2 KW - Oligodeoxyribonucleotides KW - Proto-Oncogene Proteins c-bcl-2 KW - Abridged Index Medicus KW - Index Medicus KW - Neoplasm Transplantation KW - Injections, Intraperitoneal KW - Drug Screening Assays, Antitumor KW - Animals KW - Interleukin-2 -- administration & dosage KW - Interleukin-2 -- therapeutic use KW - Mice, Inbred C3H KW - Mice KW - Proto-Oncogene Proteins c-bcl-2 -- genetics KW - Drug Synergism KW - Female KW - Lymphoma, B-Cell -- therapy KW - Immunotherapy KW - Antibodies, Neoplasm -- therapeutic use KW - Antibodies, Neoplasm -- immunology KW - Antibodies, Neoplasm -- administration & dosage KW - Antibodies, Monoclonal -- administration & dosage KW - Oligodeoxyribonucleotides -- administration & dosage KW - Antibodies, Monoclonal -- immunology KW - Antibodies, Monoclonal -- therapeutic use KW - Adjuvants, Immunologic -- administration & dosage KW - Oligodeoxyribonucleotides -- therapeutic use KW - Lymphoma, B-Cell -- immunology KW - CpG Islands KW - Adjuvants, Immunologic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78940558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Immunostimulatory+oligodeoxynucleotides+containing+CpG+motifs+enhance+the+efficacy+of+monoclonal+antibody+therapy+of+lymphoma.&rft.au=Wooldridge%2C+J+E%3BBallas%2C+Z%3BKrieg%2C+A+M%3BWeiner%2C+G+J&rft.aulast=Wooldridge&rft.aufirst=J&rft.date=1997-04-15&rft.volume=89&rft.issue=8&rft.spage=2994&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-19 N1 - Date created - 1997-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aphasia in African-Americans and Caucasians: Severity, Improvement, and Rate of Improvement AN - 85338253; llba-200005899 AB - Initial severity, amount of improvement, & rate of improvement of aphasia were compared in African-Americans & Caucasians. Study patients were aphasic subsequent to a first, left hemisphere, thromboembolic infarct, & all were entered in a 44-week treatment trial designed to provide 6-8 hours of treatment each week between 4 & 48 weeks post-onset. There was no significant difference between African-Americans & Caucasians in severity of aphasia on the Porch Index of Communicative Ability, a word fluency measure, or the Token Test prior to the initiation of treatment at 4 weeks post-onset. At 48 weeks post-onset, African-Americans performed significantly lower on the Porch Index of Communicative Ability Gestural & Graphic modality scores. Both African-American & Caucasian aphasic patients displayed significant improvement in aphasia during the 44-week treatment trial, & there were no significant differences between groups in the amount or rate of improvement. Thus, our samples of African-American & Caucasian aphasic patients displayed essentially the same initial severity, amount of improvement, & rate of improvement of aphasia during the first year post-onset. 4 Tables, 29 References. Adapted from the source document JF - Aphasiology AU - Wertz, Robert T AU - Auther, L L AU - Ross, K B AD - Veterans Administration Medical Center, Nashville, TN Y1 - 1997/04// PY - 1997 DA - Apr 1997 SP - 533 EP - 542 VL - 11 IS - 4-5 SN - 0268-7038, 0268-7038 KW - *Language Therapy (44400) KW - *Aphasia (03400) KW - *Black Americans (09100) KW - *Whites (96870) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85338253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Aphasia+in+African-Americans+and+Caucasians%3A+Severity%2C+Improvement%2C+and+Rate+of+Improvement&rft.au=Wertz%2C+Robert+T%3BAuther%2C+L+L%3BRoss%2C+K+B&rft.aulast=Wertz&rft.aufirst=Robert&rft.date=1997-04-01&rft.volume=11&rft.issue=4-5&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2003-10-01 N1 - Last updated - 2014-06-17 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - *Aphasia (03400); *Black Americans (09100); *Whites (96870); *Language Therapy (44400) ER - TY - JOUR T1 - Roles of GTP and phospholipase C in the potentiation of Ca(2+)-induced insulin secretion by glucose in rat pancreatic islets. AN - 78992190; 9135570 AB - Glucose can augment insulin secretion independently of K+ channel closure, provided cytoplasmic free Ca2+ concentration is elevated. A role for phospholipase C (PLC) in this phenomenon has been both claimed and refuted. Recently, we have shown a role for GTP in the secretory effect of glucose as well as in glucose-induced PLC activation, using islets pre-treated with GTP synthesis inhibitors such as mycophenolic acid (MPA). Therefore, in the current studies, we examined first, whether glucose augments Ca(2+)-induced PLC activation and second, whether GTP is required for this effect, when K+(ATP) channels are kept open using diazoxide. Isolated rat islets pre-labeled with [3H]myo-inositol were studied with or without first priming with glucose. There was a 98% greater augmentation of insulin secretion by 16.7 mM glucose (in the presence of diazoxide and 40 mM K+) in primed islets; however, the ability of high glucose to augment PLC activity bore no relationship to the secretory response. MPA markedly inhibited PLC in both conditions; however, insulin secretion was only inhibited (by 46%) in primed islets. None of these differences were attributable to alterations in labeling of phosphoinositides or levels of GTP or ATP. These data indicate that an adequate level of GTP is critical for glucose's potentiation of Ca(2+)-induced insulin secretion in primed islets but that PLC activation can clearly be dissociated from insulin secretion and therefore cannot be the major cause of glucose's augmentation of Ca(2+)-induced insulin secretion. JF - The Journal of endocrinology AU - Vadakekalam, J AU - Rabaglia, M E AU - Metz, S A AD - William S Middleton Veterans' Administration Hospital, Department of Medicine, University of Wisconsin-Madison 53792, USA. Y1 - 1997/04// PY - 1997 DA - April 1997 SP - 61 EP - 71 VL - 153 IS - 1 SN - 0022-0795, 0022-0795 KW - Insulin KW - 0 KW - Phosphatidylinositols KW - Potassium Channels KW - Guanosine Triphosphate KW - 86-01-1 KW - Type C Phospholipases KW - EC 3.1.4.- KW - Glucose KW - IY9XDZ35W2 KW - Diazoxide KW - O5CB12L4FN KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats KW - Phosphatidylinositols -- metabolism KW - Animals KW - Rats, Sprague-Dawley KW - Culture Techniques KW - Enzyme Activation KW - Potassium Channels -- drug effects KW - Drug Synergism KW - Diazoxide -- pharmacology KW - Male KW - Calcium -- metabolism KW - Glucose -- pharmacology KW - Islets of Langerhans -- drug effects KW - Insulin -- secretion KW - Islets of Langerhans -- secretion KW - Type C Phospholipases -- metabolism KW - Guanosine Triphosphate -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78992190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+endocrinology&rft.atitle=Roles+of+GTP+and+phospholipase+C+in+the+potentiation+of+Ca%282%2B%29-induced+insulin+secretion+by+glucose+in+rat+pancreatic+islets.&rft.au=Vadakekalam%2C+J%3BRabaglia%2C+M+E%3BMetz%2C+S+A&rft.aulast=Vadakekalam&rft.aufirst=J&rft.date=1997-04-01&rft.volume=153&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+endocrinology&rft.issn=00220795&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-19 N1 - Date created - 1997-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Patterns of content, contextual, and working memory impairments in schizophrenia and nonamnesic alcoholism. AN - 78966045; 9110327 AB - This study used tests of content memory (item recognition of words and abstract designs), context memory (order recognition of verbal and nonverbal items), and working memory (recognition at a short retention interval) to examine patterns of performance in 27 schizophrenic patients, 52 chronic alcoholic patients, and 66 healthy control participants. When performance was age- and IQ-adjusted the schizophrenia group was significantly impaired in item and order recognition of verbal and nonverbal material; the alcoholic group was impaired only in order recognition for both material types. Item- and order-recognition deficits in the schizophrenia group were greatest at the shortest retention intervals, a pattern previously observed in patients with Parkinson's disease, suggesting a prominence of a working memory deficit in schizophrenia. JF - Neuropsychology AU - Sullivan, E V AU - Shear, P K AU - Zipursky, R B AU - Sagar, H J AU - Pfefferbaum, A AD - Veterans Affairs Palo Alto Health Care System, California, USA. edie@alois.icon.palo-alto.med.va.gov Y1 - 1997/04// PY - 1997 DA - April 1997 SP - 195 EP - 206 VL - 11 IS - 2 SN - 0894-4105, 0894-4105 KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Schizophrenic Psychology KW - Memory -- physiology KW - Language KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78966045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychology&rft.atitle=Patterns+of+content%2C+contextual%2C+and+working+memory+impairments+in+schizophrenia+and+nonamnesic+alcoholism.&rft.au=Sullivan%2C+E+V%3BShear%2C+P+K%3BZipursky%2C+R+B%3BSagar%2C+H+J%3BPfefferbaum%2C+A&rft.aulast=Sullivan&rft.aufirst=E&rft.date=1997-04-01&rft.volume=11&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Neuropsychology&rft.issn=08944105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-06-27 N1 - Date created - 1997-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tornado disasters and stress responses. AN - 78957347; 9110538 AB - Each year, a number of tornados rip through Kentucky, leaving fear, destruction, and human injury in their path. Persons who endure these catastrophes often experience a variety of stress responses. The psychological and medical sequelae include depression, acute and post-traumatic stress disorders, substance abuse, anxiety, and somatization. It is especially important for the Kentucky practitioner to be able to recognize and screen for pathology following a tornado disaster in order to provide leadership in ascertaining treatment for such stress responses. JF - The Journal of the Kentucky Medical Association AU - Godleski, L S AD - VA Mental Health Clinic, Veterans Administration Medical Center, Louisville, KY 40223, USA. Y1 - 1997/04// PY - 1997 DA - April 1997 SP - 145 EP - 148 VL - 95 IS - 4 SN - 0023-0294, 0023-0294 KW - Index Medicus KW - Rats KW - Animals KW - Psychiatric Status Rating Scales KW - Risk Factors KW - Humans KW - Kentucky KW - Primary Health Care KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Anxiety Disorders -- etiology KW - Depression -- therapy KW - Stress Disorders, Post-Traumatic -- therapy KW - Depression -- etiology KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Anxiety Disorders -- therapy KW - Anxiety Disorders -- diagnosis KW - Substance-Related Disorders -- etiology KW - Disasters KW - Depression -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78957347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Kentucky+Medical+Association&rft.atitle=Tornado+disasters+and+stress+responses.&rft.au=Godleski%2C+L+S&rft.aulast=Godleski&rft.aufirst=L&rft.date=1997-04-01&rft.volume=95&rft.issue=4&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Kentucky+Medical+Association&rft.issn=00230294&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-12 N1 - Date created - 1997-05-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Impact of the Homecoming Reception on the Development of Posttraumatic Stress Disorder: The West Haven Homecoming Stress Scale (WHHSS) AN - 61549085; 9800767 AB - Describes the development of a self-report measure of the homecoming experience among Vietnam veterans with posttraumatic stress disorder (PTSD). The West Haven Homecoming Stress Scale (WHHSS), measuring frequency of events, intensity of feelings, & level of support during the first 6 months after return from overseas, & within the past 6 months, was collected from 247 male veterans who were receiving inpatient treatment for PTSD at a Veterans Administration Medical Center in West Haven, CT, 1992-1994. Homecoming stress was the most significant predictor of current PTSD symptomatology, superseding combat exposure, childhood & civilian traumas, & stressful life events. A factor analysis resulted in four orthogonal factors: shame, negative interpersonal interaction, social withdrawal, & resentment. Homecoming stress was unchanged over the course of a 4-month inpatient program. 6 Tables, 30 References. Adapted from the source document. JF - Journal of Traumatic Stress AU - Johnson, David Read AU - Lubin, Hadar AU - Rosenheck, Robert AU - Fontana, Alan AU - Southwick, Steven AU - Charney, Dennis AD - Psychology Service 116B Veterans Administration Medical Center, 950 Campbell Ave West Haven CT 06516 Y1 - 1997/04// PY - 1997 DA - April 1997 SP - 259 EP - 277 VL - 10 IS - 2 SN - 0894-9867, 0894-9867 KW - Veterans KW - Methodology (Data Collection) KW - Family Relations KW - Vietnam War KW - Males KW - Scales KW - Posttraumatic Stress Disorder KW - Home Environment KW - Connecticut KW - article KW - 0623: complex organization; military sociology KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61549085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Traumatic+Stress&rft.atitle=The+Impact+of+the+Homecoming+Reception+on+the+Development+of+Posttraumatic+Stress+Disorder%3A+The+West+Haven+Homecoming+Stress+Scale+%28WHHSS%29&rft.au=Johnson%2C+David+Read%3BLubin%2C+Hadar%3BRosenheck%2C+Robert%3BFontana%2C+Alan%3BSouthwick%2C+Steven%3BCharney%2C+Dennis&rft.aulast=Johnson&rft.aufirst=David&rft.date=1997-04-01&rft.volume=10&rft.issue=2&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Journal+of+Traumatic+Stress&rft.issn=08949867&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JTSTEB N1 - SubjectsTermNotLitGenreText - Vietnam War; Veterans; Posttraumatic Stress Disorder; Scales; Family Relations; Methodology (Data Collection); Home Environment; Males; Connecticut ER - TY - JOUR T1 - Role of CYP3A in ethanol-mediated increases in acetaminophen hepatotoxicity AN - 16101848; 4205985 AB - CYP2E is considered the only form of cytochrome P450 responsible for ethanol-mediated increases in acetaminophen hepatotoxicity. However, in experimental systems used for investigating ethanol-mediated increases in acetaminophen hepatotoxicity, animals are withdrawn from ethanol for 16 to 24 hr before the administration of acetaminophen to ensure the clearance of ethanol from the circulation. In rats, CYP2E has been shown to decrease to control levels after this time period of withdrawal from ethanol. We have previously shown in cultured human and rat hepatocytes, and in intact rats, that ethanol induces CYP3A in addition to CYP2E. To determine if there might be a role for CYP3A in ethanol-mediated APAP hepatotoxicity in addition to the recognized role for CYP2E, we investigated the effect of triacetyloleandomycin (TAO) on acetaminophen hepatotoxicity in ethanol-pretreated rats, as well as the effect of 11 hr withdrawal from ethanol on hepatic levels of CYP3A and CYP2E. TAO was dissolved in saline instead of dimethylsulfoxide, the solvent most usually employed, since dimethylsulfoxide inhibits CYP2E. Rats were administered 6.3% ethanol as part of the Lieber-DeCarli diet for 7 days, followed by replacement of the liquid diet with water for 11 hr. This 11-hr withdrawal from ethanol resulted in a decrease in hepatic levels of ethanol-induced CYP2E; however, considerable induction was still evident. There was no significant decrease in CYP3A. TAO completely prevented the histologically observed liver damage from acetaminophen in ethanol-pretreated rats, but did not prevent the increase in serum levels of AST. In ethanol-pretreated rats, exposure to APAP in the absence of TAO was associated with a 75% decrease in CYP3A, compared to animals exposed to APAP in the presence of TAO. These results suggest that CYP3A may have been suicidally inactivated by acetaminophen in the absence of TAO. Our findings suggest that CYP3A has a major role in ethanol-mediated increases in acetaminophen hepatotoxicity. JF - Toxicology and Applied Pharmacology AU - Kostrubsky, V E AU - Szakacs, J G AU - Jeffery, E H AU - Wood, S G AU - Bement, W J AU - Wrighton, SA AU - Sinclair, PR AU - Sinclair, J F AD - Research 151, Veterans Administration Medical Center, White River Junction, VT 05009, USA Y1 - 1997/04// PY - 1997 DA - Apr 1997 SP - 315 EP - 323 VL - 143 IS - 2 SN - 0041-008X, 0041-008X KW - acetaminophen KW - ethanol KW - cytochrome P450 KW - Toxicology Abstracts KW - analgesics KW - liver KW - X 24112:Chronic exposure KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16101848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Role+of+CYP3A+in+ethanol-mediated+increases+in+acetaminophen+hepatotoxicity&rft.au=Kostrubsky%2C+V+E%3BSzakacs%2C+J+G%3BJeffery%2C+E+H%3BWood%2C+S+G%3BBement%2C+W+J%3BWrighton%2C+SA%3BSinclair%2C+PR%3BSinclair%2C+J+F&rft.aulast=Kostrubsky&rft.aufirst=V&rft.date=1997-04-01&rft.volume=143&rft.issue=2&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - analgesics; liver ER - TY - JOUR T1 - Esophageal wall thickening: a CT finding in diffuse esophageal spasm. AN - 85267298; pmid-9071309 AB - We report three patients with esophageal wall thickening, incidentally found at CT, in whom further evaluation led to the diagnosis of diffuse esophageal spasm (DES). All cases showed smooth, symmetric, circumferential wall thickening of the distal two-thirds of the esophagus with normal periesophageal fat. No lung parenchymal abnormalities suggestive of aspiration were seen. DES, although uncommon, is another benign condition that should be included in the differential diagnosis of esophageal wall thickening detected by CT. JF - Journal of Computer Assisted Tomography AU - Nino-Murcia, M AU - Stark, P AU - Triadafilopoulos, G AD - Radiology Service, Veterans Administration Palo Alto Health Care System, CA 94304, USA. PY - 1997 SP - 318 EP - 321 VL - 21 IS - 2 SN - 0363-8715, 0363-8715 KW - Esophagus KW - Esophageal Spasm, Diffuse KW - Human KW - Aged KW - Middle Age KW - Case Report KW - Female KW - Male KW - Tomography, X-Ray Computed UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85267298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Computer+Assisted+Tomography&rft.atitle=Esophageal+wall+thickening%3A+a+CT+finding+in+diffuse+esophageal+spasm.&rft.au=Nino-Murcia%2C+M%3BStark%2C+P%3BTriadafilopoulos%2C+G&rft.aulast=Nino-Murcia&rft.aufirst=M&rft.date=1997-03-01&rft.volume=21&rft.issue=2&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Journal+of+Computer+Assisted+Tomography&rft.issn=03638715&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Prospective long-term endoscopic and histological follow-up of short segment Barrett's esophagus: comparison with traditional long segment Barrett's esophagus. AN - 85213899; pmid-9068459 AB - OBJECTIVES: Barrett's esophagus is associated with adenocarcinoma of the cardia and esophagus, regardless of its extent. The aim of this study was to compare the prevalence and incidence of dysplasia and adenocarcinoma in short segment and traditional long segment Barrett's esophagus. METHODS: Seventy-four patients with short segment Barrett's and 78 with traditional Barrett's entered the study. RESULTS: There were no significant differences in age or gender between the two groups of patients with Barrett's esophagus. A greater percentage of patients with short segment barrett's were black (p = 0.04). The prevalence of dysplasia at diagnosis in patients with short segment Barrett's was 8.1% versus 24.4% in patients with traditional Barrett's (p < 0.007). Adenocarcinoma was noted at diagnosis only in patients with traditional Barrett's (p < 0.0005). Twenty-six patients with short segment Barrett's and 29 with traditional Barrett's were followed prospectively for 12-40 months. Dysplasia developed during follow-up in two patients with short segment Barrett's and in six patients with traditional Barrett's (p < 0.05). Neither high grade dysplasia nor cancer developed in any patients with short segment Barrett's. High grade dysplasia did develop in two patients with traditional Barrett's esophagus, and mucosal adenocarcinoma developed in one. The frequency of dysplasia on the latest surveillance examination continued to be significantly higher for patients with traditional Barrett's (p = 0.03). Follow-up surveillance biopsy specimens of Barrett's mucosa frequently demonstrated an absence of goblet cells in patients with short segment Barrett's compared with patients with traditional Barrett's (p < 0.0001). CONCLUSIONS: The prevalence of dysplasia or adenocarcinoma and the incidence of dysplasia in patients with traditional Barrett's esophagus are significantly higher than in patients with short segment Barrett's esophagus. Further prospective surveillance is required to determine whether the incidence of adenocarcinoma in patients with short segment Barrett's esophagus is significantly lower. JF - The American Journal of Gastroenterology AU - Weston, A P AU - Krmpotich, P T AU - Cherian, R AU - Dixon, A AU - Topalosvki, M AD - Veterans Administration Medical Center, Kansas City, Missouri, USA. PY - 1997 SP - 407 EP - 413 VL - 92 IS - 3 SN - 0002-9270, 0002-9270 KW - Esophagus KW - Age Factors KW - Negroid Race KW - Sex Factors KW - Esophageal Neoplasms KW - Human KW - Biopsy KW - Longitudinal Studies KW - Prospective Studies KW - Comparative Study KW - Stomach Neoplasms KW - Mucous Membrane KW - Cardia KW - Middle Age KW - Incidence KW - Esophagogastric Junction KW - Support, U.S. Gov't, Non-P.H.S. KW - Follow-Up Studies KW - Epithelium KW - Barrett Esophagus KW - Adenocarcinoma KW - Cell Transformation, Neoplastic KW - Female KW - Male KW - Prevalence KW - Esophagoscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85213899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Prospective+long-term+endoscopic+and+histological+follow-up+of+short+segment+Barrett%27s+esophagus%3A+comparison+with+traditional+long+segment+Barrett%27s+esophagus.&rft.au=Weston%2C+A+P%3BKrmpotich%2C+P+T%3BCherian%2C+R%3BDixon%2C+A%3BTopalosvki%2C+M&rft.aulast=Weston&rft.aufirst=A&rft.date=1997-03-01&rft.volume=92&rft.issue=3&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Resistance to mineralocorticoids in Wistar-Furth rats. AN - 78903413; 9087624 AB - Wistar-Furth rats (WF) do not develop hypertension when treated with salt and mineralocorticoids and therefore may be useful for investigating the mechanisms of mineralocorticoid action and hypertension. In the present studies, we determined vascular and renal responses of WF to mineralocorticoids. Control Wistar rats (W) developed deoxycorticosterone acetate (DOCA)-NaCl and dexamethasone hypertension, whereas WF rats developed dexamethasone hypertension only. Aldosterone treatment of vascular smooth muscle cells cultured from WF resulted in 82% less upregulation of angiotensin II radioligand binding, 50% less induction of angiotensin II AT1a receptor mRNA, and 76% less potentiation of angiotensin II-stimulated inositol phosphates than did aldosterone treatment of cells from W. Similarly, DOCA-NaCl potentiated angiotensin II- and phenylephrine-stimulated contractions in aortic rings from W but not from WF. Although DOCA-NaCl treatment affected hypokalemia to an equal degree in WF and W, increases in renal citrate synthase activity (a specific renal mineralocorticoid response) were greater in W than in WF. WF manifest a partial defect in mineralocorticoid responsiveness in vascular smooth muscle and, possibly, in the kidney. JF - The American journal of physiology AU - Ullian, M E AU - Islam, M M AU - Robinson, C J AU - Fitzgibbon, W R AU - Tobin, E T AU - Paul, R V AD - Ralph H. Johnson Veterans Administration Medical Center and Medical University of South Carolina, Charleston 29425, USA. Y1 - 1997/03// PY - 1997 DA - March 1997 SP - H1454 EP - H1461 VL - 272 IS - 3 Pt 2 SN - 0002-9513, 0002-9513 KW - RNA, Messenger KW - 0 KW - Receptor, Angiotensin, Type 1 KW - Receptors, Angiotensin KW - Sodium, Dietary KW - Angiotensin II KW - 11128-99-7 KW - Desoxycorticosterone KW - 40GP35YQ49 KW - Aldosterone KW - 4964P6T9RB KW - Dexamethasone KW - 7S5I7G3JQL KW - Citrate (si)-Synthase KW - EC 2.3.3.1 KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Animals KW - Aorta KW - Aldosterone -- pharmacology KW - Transcription, Genetic KW - RNA, Messenger -- biosynthesis KW - Rats KW - Cells, Cultured KW - Rats, Inbred WF KW - Body Weight -- drug effects KW - Potassium -- urine KW - Potassium -- blood KW - Rats, Wistar KW - Citrate (si)-Synthase -- metabolism KW - Up-Regulation KW - Time Factors KW - Species Specificity KW - Hypertension -- chemically induced KW - Angiotensin II -- metabolism KW - Hypertension -- physiopathology KW - Dexamethasone -- pharmacology KW - Muscle, Smooth, Vascular -- drug effects KW - Desoxycorticosterone -- pharmacology KW - Muscle, Smooth, Vascular -- metabolism KW - Blood Pressure -- drug effects KW - Receptors, Angiotensin -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78903413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Resistance+to+mineralocorticoids+in+Wistar-Furth+rats.&rft.au=Ullian%2C+M+E%3BIslam%2C+M+M%3BRobinson%2C+C+J%3BFitzgibbon%2C+W+R%3BTobin%2C+E+T%3BPaul%2C+R+V&rft.aulast=Ullian&rft.aufirst=M&rft.date=1997-03-01&rft.volume=272&rft.issue=3+Pt+2&rft.spage=H1454&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-04-28 N1 - Date created - 1997-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - HCl-induced cell edema in primary cultured rabbit esophageal epithelium. AN - 78850128; 9041246 AB - In a prior study, esophageal epithelial cells within intact epithelium were observed to swell after exposure to low extracellular pH (pHo) caused by activation of a bumetanide-sensitive NaK2Cl cotransporter. Because these results were obtained by correlation of tissue wet-weight gain with morphological evidence of cell swelling, another method was selected to confirm and extend these findings. Primary cultured rabbit esophageal cells were loaded with the fluorescent dye 2'-7'-bis(carboxyethyl)-5,6-carboxyfluorescein so that changes in intracellular pH (pHi) and cell volume could be simultaneously monitored by microfluorimetry. Cells exposed to low pHo in both bicarbonate-free and bicarbonate-containing buffers produced a decline in pHi to as low as 6.5, but this occurred without change in volume. However, when pHo was lowered to < or = 2, pHi declined to <6.5 and volume increased by 25% in 3 minutes. Removal of Na+, K+, or Cl- or adding bumetanide inhibited acid-induced swelling. Also, swelling was inhibited when cells were acidified in Ca2+-free media and eliminated by adding 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid to Ca2+-free media. Esophageal cells swell when low pHo reduces pHi to <6.5. At pHi <6.5, swelling occurs through excess osmolyte (and consequently water) uptake via a bumetanide-sensitive NaK2Cl cotransporter. Activation of this enzyme at low pHi seems to be mediated by increases in cell Ca2+. JF - Gastroenterology AU - Tobey, N A AU - Koves, G AU - Orlando, R C AD - Department of Medicine, Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, Louisiana, USA. Y1 - 1997/03// PY - 1997 DA - March 1997 SP - 847 EP - 854 VL - 112 IS - 3 SN - 0016-5085, 0016-5085 KW - Carrier Proteins KW - 0 KW - Sodium-Potassium-Chloride Symporters KW - Hydrochloric Acid KW - QTT17582CB KW - Calcium KW - SY7Q814VUP KW - Abridged Index Medicus KW - Index Medicus KW - Calcium -- metabolism KW - Animals KW - Cells, Cultured KW - Hydrogen-Ion Concentration KW - Carrier Proteins -- physiology KW - Rabbits KW - Esophagus -- drug effects KW - Edema -- chemically induced KW - Esophagus -- metabolism KW - Hydrochloric Acid -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78850128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=HCl-induced+cell+edema+in+primary+cultured+rabbit+esophageal+epithelium.&rft.au=Tobey%2C+N+A%3BKoves%2C+G%3BOrlando%2C+R+C&rft.aulast=Tobey&rft.aufirst=N&rft.date=1997-03-01&rft.volume=112&rft.issue=3&rft.spage=847&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-20 N1 - Date created - 1997-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sex-Role Egalitarianism Scale: Development, Psychometric Properties, and Recommendations for Future Research AN - 61453200; 9800429 AB - Examines the Sex-Role Egalitarianism Scale, which was developed to measure attitudes toward the equality of women & men across content domains representing marital, parental, employment, social-interpersonal-heterosexual, & educational roles. The instrument exists in four versions: two alternate 95-item full forms & two alternate 25-item abbreviated forms. Reliability indices derived from a classical test-theory approach, multifaceted generalizability procedures, & an item-response theory-based analysis all support consistence of precision of measurement. Evidence for convergent, discriminant & nomological validity is presented, along with a series of recommendations for future psychometric & substantive research using the scale. 1 Table, 1 Appendix, 48 References. Adapted from the source document. JF - Psychology of Women Quarterly AU - King, Lynda A AU - King, Daniel W AD - National Center PTSD Boston Veterans Affairs Medical Center, 150 South Huntington Ave MA 02130 king.lynda@boston.va.gov Y1 - 1997/03// PY - 1997 DA - March 1997 SP - 71 EP - 87 VL - 21 IS - 1 SN - 0361-6843, 0361-6843 KW - Scales KW - Sex Differences KW - Attitude Measures KW - Sex Role Attitudes KW - Egalitarianism KW - article KW - 0312: social psychology; personality & social roles (individual traits, social identity, adjustment, conformism, & deviance) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61453200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Women+Quarterly&rft.atitle=Sex-Role+Egalitarianism+Scale%3A+Development%2C+Psychometric+Properties%2C+and+Recommendations+for+Future+Research&rft.au=King%2C+Lynda+A%3BKing%2C+Daniel+W&rft.aulast=King&rft.aufirst=Lynda&rft.date=1997-03-01&rft.volume=21&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Women+Quarterly&rft.issn=03616843&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - PWOQDY N1 - SubjectsTermNotLitGenreText - Sex Role Attitudes; Sex Differences; Egalitarianism; Attitude Measures; Scales ER - TY - JOUR T1 - Recovery of pituitary function after treatment with a targeted cytotoxic analog of luteinizing hormone-releasing hormone. AN - 78815216; 9037068 AB - Recently, we developed a targeted cytotoxic analog AN-207 of luteinizing hormone-releasing hormone (LH-RH), consisting of an intensely potent derivative of doxorubicin, 2-pyrrolinodoxorubicin (AN-201) conjugated to carrier agonist [D-Lys6]LH-RH. In this study, we investigated the effects of cytotoxic analog AN-207, designed for targeted chemotherapy and radical AN-201 on pituitary function in rats. A selective damage to the pituitary gonadotroph cells was found at 1 week after a single i.v. injection of 150 nmol/kg AN-207, as evidenced by a 63% decrease in the LH-RH-stimulated release of LH in vitro. The release of growth hormone (GH) and thyrotropin (TSH), stimulated by GH-releasing hormone (GH-RH) and TSH-releasing hormone (TRH), respectively, was reduced by only 11-12%. In contrast, even a smaller dose of 75 nmol/kg of AN-201 nonselectively damaged pituitary function, reducing the stimulated release of LH, GH, and TSH by 57%, 74%, and 67%, respectively. Two weeks after administration, the LH-RH-stimulated LH release in vivo entirely normalized in the AN-207-treated rats, and only a 13% decrease in the LH response was found in the group given AN-201. GH and TSH responses to receptor-mediated stimuli with GH-RH and TRH were normal at 2 weeks in both treated groups. Neither cytotoxic compound caused changes in the concentration of pituitary LH, GH, or TSH, as determined by RIA at 1 week and 7 weeks after treatment. This study demonstrates that the cytotoxic LH-RH analog AN-207 exerts highly selective effects on the gonadotroph cells containing LH-RH receptors and is less toxic for other cells. Conversely, its cytotoxic radical AN-201 nonselectively damages the pituitary cells. The damaging effect of both cytotoxic compounds on pituitary functions is reversible. In view of its high selectivity and reduced toxicity, AN-207 could be a potential therapeutic agent for the treatment of tumors that possess receptors for LH-RH such as prostatic, mammary, ovarian, and endometrial cancers. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Kovacs, M AU - Schally, A V AU - Nagy, A AU - Koppan, M AU - Groot, K AD - Endocrine, Polypeptide, and Cancer Institute, Veterans Administration Medical Center, Tulane University School of Medicine, New Orleans, LA 70146, USA. Y1 - 1997/02/18/ PY - 1997 DA - 1997 Feb 18 SP - 1420 EP - 1425 VL - 94 IS - 4 SN - 0027-8424, 0027-8424 KW - Antineoplastic Agents KW - 0 KW - Cytotoxins KW - Pyrroles KW - AN 204 KW - 175795-76-3 KW - AN 207 KW - 179910-83-9 KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Doxorubicin KW - 80168379AG KW - Luteinizing Hormone KW - 9002-67-9 KW - Thyrotropin KW - 9002-71-5 KW - Growth Hormone KW - 9002-72-6 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Pituitary Function Tests KW - Body Weight -- drug effects KW - Growth Hormone -- analysis KW - Menstrual Cycle -- drug effects KW - Pyrroles -- pharmacology KW - Luteinizing Hormone -- analysis KW - Female KW - Thyrotropin -- analysis KW - Antineoplastic Agents -- adverse effects KW - Pituitary Gland, Anterior -- drug effects KW - Doxorubicin -- analogs & derivatives KW - Doxorubicin -- pharmacology KW - Cytotoxins -- pharmacology KW - Gonadotropin-Releasing Hormone -- pharmacology KW - Gonadotropin-Releasing Hormone -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78815216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Recovery+of+pituitary+function+after+treatment+with+a+targeted+cytotoxic+analog+of+luteinizing+hormone-releasing+hormone.&rft.au=Kovacs%2C+M%3BSchally%2C+A+V%3BNagy%2C+A%3BKoppan%2C+M%3BGroot%2C+K&rft.aulast=Kovacs&rft.aufirst=M&rft.date=1997-02-18&rft.volume=94&rft.issue=4&rft.spage=1420&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-27 N1 - Date created - 1997-03-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Endocrinology. 1993 May;132(5):1991-2000 [8477650] Pharmacol Ther. 1991;49(3):293-309 [2052627] Prostate. 1993;23(2):165-78 [8378189] Cancer Res. 1993 Nov 15;53(22):5439-46 [8221683] J Clin Endocrinol Metab. 1993 Dec;77(6):1458-64 [8263128] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7090-4 [7518926] Anticancer Drugs. 1994 Apr;5(2):115-30 [8049494] Hum Reprod. 1994 Jul;9(7):1364-79 [7962452] Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2464-9 [8637897] Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7269-73 [8692981] Eur J Endocrinol. 1996 Aug;135(2):135-43 [8810721] Breast Cancer Res Treat. 1996;40(2):129-39 [8879679] Nat New Biol. 1972 Jan 5;235(53):17-9 [4502404] Anal Biochem. 1976 May 7;72:248-54 [942051] Science. 1977 Aug 5;197(4303):527-32 [877572] Science. 1982 Jul 16;217(4556):248-50 [7089561] Nature. 1985 Jan 17-23;313(5999):231-3 [2982100] Prostate. 1989;14(3):191-208 [2471961] J Clin Lab Anal. 1989;3(3):137-47 [2569034] J Natl Cancer Inst. 1989 Oct 4;81(19):1455-63 [2550658] Br J Cancer. 1990 Jul;62(1):96-9 [2117967] Cancer Res. 1991 May 15;51(10):2577-81 [2021939] Biomed Pharmacother. 1992;46(10):465-71 [1363977] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comments on "Aphasia Treatment in the Early Postonset Period: Managing Our Resources Effectively" AN - 85643149; 9804678 AB - A response to Robert C. Marshall (1997 [see abstract 9804670]) concerning aphasia treatment decisions in the early postonset period. Several studies cited by Marshall concerning the benefits of early vs later aphasia treatment are examined, & Marshall's conclusions based on their results are questioned because of a lack of valid subject selection criteria & needed methodological controls. Likewise, studies cited by Marshall regarding type of treatment are noted as not providing the data necessary to make decisions about type of treatment. It is asserted that the literature does not provide sufficient empirical evidence to give direction for changes in early aphasia care. 30 References. D. Taylor JF - American Journal of Speech-Language Pathology AU - Wertz, Robert T AD - Audiology & Speech Pathology Veterans Administration Medical Center, 1310 24th Ave South Nashville TN 37212 Y1 - 1997/02// PY - 1997 DA - February 1997 SP - 12 EP - 18 VL - 6 IS - 1 SN - 1058-0360, 1058-0360 KW - Language Therapy (44400) KW - Aphasia (03400) KW - Research Design (72950) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85643149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Speech-Language+Pathology&rft.atitle=Comments+on+%22Aphasia+Treatment+in+the+Early+Postonset+Period%3A+Managing+Our+Resources+Effectively%22&rft.au=Wertz%2C+Robert+T&rft.aulast=Wertz&rft.aufirst=Robert&rft.date=1997-02-01&rft.volume=6&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Speech-Language+Pathology&rft.issn=10580360&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJSPFZ N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Language Therapy (44400); Research Design (72950) ER - TY - JOUR T1 - Phase I trial of etoposide, carboplatin, and GM-CSF in extensive small-cell lung cancer: a Cancer and Leukemia Group B study (CALGB 8832). AN - 85253663; pmid-9020283 AB - The maximum tolerated dose (MTD) of etoposide and carboplatin without growth factor support was previously defined by Cancer and Leukemia Group B (CALGB) as 200 and 125 mg/m2/day x 3, respectively, given every 28 days to previously untreated patients who have extensive, small-cell lung cancer (SCLC). Myelosuppression was dose-limiting. The purpose of this phase I trial was to determine if granulocyte macrophage colony-stimulating factor (GM-CSF) support allows the dosage of the combination of etoposide and carboplatin to be increased above the previously determined MTD. In this CALGB study of 44 evaluable patients with performance status 0-2, cohorts were treated with etoposide and carboplatin given intravenously on days 1-3 followed by GM-CSF (molgramostim) given subcutaneously on days 4-18. Four dose levels of bacteria-derived recombinant GM-CSF (5, 10, 20 microg/kg/day and 5 microg/kg every 12 h), three dose levels of etoposide (200, 250, and 300 mg/m2/day x 3), and two dose levels of carboplatin (125 and 150 mg/m2/day x 3) were evaluated. There was no chemotherapy dose escalation in individual patients. With 5 microg/kg/d GM-CSF, the first etoposide and carboplatin cycle of 300 and 150 mg/m2/day x 3, respectively, could be administered with acceptable toxicity. However, GM-CSF did not allow repeated administration of this dose-escalated regimen every 21 days, since delayed platelet and/or neutrophil recovery was dose limiting in later cycles. These results demonstrate that GM-CSF alone has limited capability to support the repeated administration of high doses of etoposide and carboplatin. CALGB currently is testing the ability of interleukin (IL)-6 given with GM-CSF to ameliorate the cumulative myelosuppression of this intense regimen. JF - American Journal of Clinical Oncology: The Official Publication of the American Radium Society AU - Luikart, S D AU - Herndon, J E AU - Hollis, D R AU - MacDonald, M AU - Maurer, L H AU - Crawford, J AU - Clamon, G H AU - Wright, J AU - Perry, M C AU - Ozer, H AU - Green, M R AD - Veterans Administration Medical Center and the University of Minnesota Medical Center, Minneapolis 55417, USA. PY - 1997 SP - 24 EP - 30 VL - 20 IS - 1 SN - 0277-3732, 0277-3732 KW - Drug Administration Schedule KW - Support, U.S. Gov't, P.H.S. KW - Dose-Response Relationship, Drug KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - Human KW - Aged KW - Carboplatin KW - Carcinoma, Small Cell KW - Lung Neoplasms KW - Adult KW - Antineoplastic Combined Chemotherapy Protocols KW - Middle Age KW - Etoposide KW - Male KW - Female KW - Remission Induction KW - Survival Analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85253663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Oncology%3A+The+Official+Publication+of+the+American+Radium+Society&rft.atitle=Phase+I+trial+of+etoposide%2C+carboplatin%2C+and+GM-CSF+in+extensive+small-cell+lung+cancer%3A+a+Cancer+and+Leukemia+Group+B+study+%28CALGB+8832%29.&rft.au=Luikart%2C+S+D%3BHerndon%2C+J+E%3BHollis%2C+D+R%3BMacDonald%2C+M%3BMaurer%2C+L+H%3BCrawford%2C+J%3BClamon%2C+G+H%3BWright%2C+J%3BPerry%2C+M+C%3BOzer%2C+H%3BGreen%2C+M+R&rft.aulast=Luikart&rft.aufirst=S&rft.date=1997-02-01&rft.volume=20&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Oncology%3A+The+Official+Publication+of+the+American+Radium+Society&rft.issn=02773732&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Medical therapy for intracerebral hematoma with the gamma-aminobutyric acid-A agonist muscimol. AN - 78843172; 9040695 AB - No therapy has been rigorously proven effective for intracerebral hematoma, although surgery is frequently used for some types of lobar hemorrhages. Since intracerebral mass causes significant ischemia in surrounding brain, we reasoned that anti-ischemia therapy might improve outcome after experimental hematoma. We stereotaxically injected varying doses of bacterial collagenase into the caudate nucleus of rats. Four hours later we administered intravenously 2 mg/kg muscimol, a potent agonist of the gamma-aminobutyric acid-A receptor (n = 20); 1 mg/kg MK-801, an antagonist of the N-methyl-D-aspartate receptor (n = 17); or saline (n = 28). Forty-eight hours after collagenase injection we rated each animal using a standard rodent neurological examination. The ratings were compared with the amounts of injected collagenase by the quantal bioassay procedure. Brains were then prepared for histomorphometry and brain volumes estimated. We found that the ED50 for collagenase (amount of enzyme that renders 50% of the subjects abnormal) was 0.77 +/- 0.09 U in saline-treated subjects. Treatment with muscimol significantly increased the ED50 to 1.2 +/- 0.21 U, for a potency ratio of 1.55 +/- 0.34 (t = 1.7, P < .05). MK-801 did not affect outcome. Volume of hematoma was significantly correlated with amount of injected collagenase (n = 33, r = .64, P < .001). Volumes of basal ganglia and white matter were significantly reduced by hemorrhage, and muscimol partially ameliorated this. We conclude that muscimol significantly improves neurological outcome after intracerebral hematoma. JF - Stroke AU - Lyden, P D AU - Jackson-Friedman, C AU - Lonzo-Doktor, L AD - Neurology and Research Services of the San Diego Veterans Administration Medical Center, USA. Y1 - 1997/02// PY - 1997 DA - February 1997 SP - 387 EP - 391 VL - 28 IS - 2 SN - 0039-2499, 0039-2499 KW - GABA Antagonists KW - 0 KW - GABA-A Receptor Antagonists KW - Neuroprotective Agents KW - Muscimol KW - 2763-96-4 KW - Collagenases KW - EC 3.4.24.- KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Caudate Nucleus -- pathology KW - Collagenases -- toxicity KW - Drug Evaluation, Preclinical KW - Male KW - Cerebral Hemorrhage -- chemically induced KW - Cerebral Hemorrhage -- drug therapy KW - GABA Antagonists -- pharmacology KW - Hematoma -- pathology KW - Neuroprotective Agents -- pharmacology KW - GABA Antagonists -- therapeutic use KW - Cerebral Hemorrhage -- pathology KW - Muscimol -- therapeutic use KW - Neuroprotective Agents -- therapeutic use KW - Hematoma -- drug therapy KW - Hematoma -- chemically induced KW - Muscimol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78843172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stroke&rft.atitle=Medical+therapy+for+intracerebral+hematoma+with+the+gamma-aminobutyric+acid-A+agonist+muscimol.&rft.au=Lyden%2C+P+D%3BJackson-Friedman%2C+C%3BLonzo-Doktor%2C+L&rft.aulast=Lyden&rft.aufirst=P&rft.date=1997-02-01&rft.volume=28&rft.issue=2&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Stroke&rft.issn=00392499&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-20 N1 - Date created - 1997-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nitric oxide and the neurotoxic effects of methamphetamine and 3,4-methylenedioxymethamphetamine. AN - 78816946; 9023310 AB - The role of nitric oxide (NO) in the long-term, amine-depleting effects of methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA) was investigated in the rodent central nervous system. The NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) antagonized the dopamine- and serotonin-depleting effects of both METH and MDMA. The protective actions of L-NAME in METH-treated mice were reversed by prior administration of the NO generator isosorbide dinitrate. However, pretreatment with N(G)-monomethyl-L-arginine or N(G)-nitro-L-arginine, two other NO synthase inhibitors, failed to block the neurotoxic effects of METH or MDMA. L-NAME was also the only NO synthase inhibitor that antagonized the hyperthermic effects of METH, reducing colonic temperatures in mice by a mean of 3 degrees C, in comparison with control. Moreover, if the hypothermic effects of L-NAME in METH-treated mice were prevented by raising the ambient room temperature, the dopamine-depleting actions of the stimulant were fully restored. The latter findings suggest that it is the hypothermic actions of L-NAME, rather than its NO inhibitory properties, that are responsible for the prevention of neurotoxicity. Together with the results of the N(G)-monomethyl-L-arginine and N(G)-nitro-L-arginine experiments, the data suggest that NO plays little or no role in the toxic mechanism of action of METH or MDMA. JF - The Journal of pharmacology and experimental therapeutics AU - Taraska, T AU - Finnegan, K T AD - Department of Psychiatry, University of Utah School of Medicine, Veterans Administration Medical Center, Salt Lake City 84148, USA. Y1 - 1997/02// PY - 1997 DA - February 1997 SP - 941 EP - 947 VL - 280 IS - 2 SN - 0022-3565, 0022-3565 KW - Catecholamines KW - 0 KW - Neurotoxins KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - Nitroarginine KW - 2149-70-4 KW - Nitric Oxide KW - 31C4KY9ESH KW - Serotonin KW - 333DO1RDJY KW - Methamphetamine KW - 44RAL3456C KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Isosorbide Dinitrate KW - IA7306519N KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Dopamine KW - VTD58H1Z2X KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Body Temperature -- drug effects KW - Corpus Striatum -- metabolism KW - Hydroxyindoleacetic Acid -- metabolism KW - Hippocampus -- metabolism KW - Dopamine -- metabolism KW - Mice KW - Homovanillic Acid -- metabolism KW - Rats KW - Mice, Inbred Strains KW - Rats, Sprague-Dawley KW - 3,4-Dihydroxyphenylacetic Acid -- metabolism KW - Nitric Oxide Synthase -- antagonists & inhibitors KW - Frontal Lobe -- metabolism KW - Male KW - NG-Nitroarginine Methyl Ester -- pharmacology KW - Catecholamines -- metabolism KW - Brain -- drug effects KW - Nitroarginine -- pharmacology KW - N-Methyl-3,4-methylenedioxyamphetamine -- toxicity KW - Nitric Oxide -- pharmacology KW - Nitric Oxide -- physiology KW - Brain -- metabolism KW - Serotonin -- metabolism KW - Isosorbide Dinitrate -- pharmacology KW - Methamphetamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78816946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Nitric+oxide+and+the+neurotoxic+effects+of+methamphetamine+and+3%2C4-methylenedioxymethamphetamine.&rft.au=Taraska%2C+T%3BFinnegan%2C+K+T&rft.aulast=Taraska&rft.aufirst=T&rft.date=1997-02-01&rft.volume=280&rft.issue=2&rft.spage=941&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-17 N1 - Date created - 1997-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulation of glycosylphosphatidylinositol-specific phospholipase D secretion from beta TC3 cells. AN - 78798830; 9003020 AB - Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) is abundant in mammalian serum, but the source of the circulating enzyme is unknown. Pancreatic islets have been reported to contain and secrete GPI-PLD. In this report we examined the regulation of GPI-PLD secretion from beta TC3 cells, a mouse insulinoma cell line. In the absence of glucose, phorbol myristic acid (0.1 microM) stimulated insulin secretion by 2.5-fold and GPI-PLD secretion by 2-fold. Carbachol (5 microM), glucagon-like peptide I-(7-36) amide (0.1 microM), and isobutylmethylxanthine (0.1 mM) had no significant effect on insulin or GPI-PLD secretion in the absence of glucose. Glucose (16.7 mM) stimulated both GPI-PLD and insulin secretion from beta TC3 cells by 55% and 235%, respectively. In addition, glucose potentiated the secretagogue effect of isobutylmethylxanthine, phorbol myristic acid, and glucagon-like peptide I on both insulin and GPI-PLD secretion. By immunohistochemistry and confocal microscopy, beta TC3 cells contain both insulin and GPI-PLD, which generally colocalized intracellularly. However, GPI-PLD secretion differed from insulin secretion by a higher rate of basal release (2.8% vs. 0.23%/h), a lower magnitude of response to secretagogues, and a more prolonged period of increased secretion. These results demonstrate that beta TC3 cells secrete GPI-PLD in response to insulin secretagogues and suggest that GPI-PLD may be secreted via the regulated pathway in these cells. JF - Endocrinology AU - Deeg, M A AU - Verchere, C B AD - Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA. deeg.mark@indianapolis.va.gov Y1 - 1997/02// PY - 1997 DA - February 1997 SP - 819 EP - 826 VL - 138 IS - 2 SN - 0013-7227, 0013-7227 KW - Insulin KW - 0 KW - Peptide Fragments KW - glucagon-like peptide 1 (7-36)amide KW - 119637-73-9 KW - Glucagon-Like Peptides KW - 62340-29-8 KW - Glucagon-Like Peptide 1 KW - 89750-14-1 KW - Carbachol KW - 8Y164V895Y KW - Glucagon KW - 9007-92-5 KW - Cycloheximide KW - 98600C0908 KW - Phospholipase D KW - EC 3.1.4.4 KW - glycoprotein phospholipase D KW - EC 3.1.4.50 KW - Glucose KW - IY9XDZ35W2 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - 1-Methyl-3-isobutylxanthine KW - TBT296U68M KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Insulin -- analysis KW - Mice KW - Insulin -- secretion KW - Tumor Cells, Cultured KW - Glucose -- pharmacology KW - Cycloheximide -- pharmacology KW - Kinetics KW - Peptide Fragments -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - 1-Methyl-3-isobutylxanthine -- pharmacology KW - Carbachol -- pharmacology KW - Immunohistochemistry KW - Insulinoma -- enzymology KW - Islets of Langerhans -- drug effects KW - Phospholipase D -- analysis KW - Pancreatic Neoplasms -- enzymology KW - Islets of Langerhans -- enzymology KW - Phospholipase D -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78798830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Regulation+of+glycosylphosphatidylinositol-specific+phospholipase+D+secretion+from+beta+TC3+cells.&rft.au=Deeg%2C+M+A%3BVerchere%2C+C+B&rft.aulast=Deeg&rft.aufirst=M&rft.date=1997-02-01&rft.volume=138&rft.issue=2&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-02-18 N1 - Date created - 1997-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Posttraumatic Stress Disorder Associated with Peacekeeping Duty in Somalia for U.S. Military Personnel AN - 61427337; 9712858 AB - To examine the prevalence of posttraumatic stress disorder associated with military peacekeeping duty, scale data were collected from 3,461 US armed services members who had served in the humanitarian relief mission in Somalia. Military experiences were rated more positively than humanitarian experiences, with African American & Hispanic soldiers valuing the humanitarian mission more than Caucasian soldiers. Gender & racial differences in posttraumatic stress disorder were not statistically significant. 4 Tables, 32 References. B. Persky JF - The American Journal of Psychiatry AU - Litz, Brett T AU - Orsillo, Susan M AU - Friedman, Matthew AU - Ehlich, Peter AU - Batres, Alfonso AD - National Center Post-Traumatic Stress Disorder Veterans Administration Medical Center, 150 South Huntington Ave Boston MA 02130 litz.brett@boston.va.gov Y1 - 1997/02// PY - 1997 DA - February 1997 SP - 178 EP - 184 VL - 154 IS - 2 SN - 0002-953X, 0002-953X KW - posttraumatic stress disorder, US military personnel, peacekeeping duty, Somalia, gender/race differences KW - scale data KW - Black Americans KW - Hispanic Americans KW - Humanitarianism KW - Military Personnel KW - Sex Differences KW - United States of America KW - Racial Differences KW - Posttraumatic Stress Disorder KW - Somalia KW - article KW - 0623: complex organization; military sociology KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61427337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Posttraumatic+Stress+Disorder+Associated+with+Peacekeeping+Duty+in+Somalia+for+U.S.+Military+Personnel&rft.au=Litz%2C+Brett+T%3BOrsillo%2C+Susan+M%3BFriedman%2C+Matthew%3BEhlich%2C+Peter%3BBatres%2C+Alfonso&rft.aulast=Litz&rft.aufirst=Brett&rft.date=1997-02-01&rft.volume=154&rft.issue=2&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Somalia; Humanitarianism; Posttraumatic Stress Disorder; Military Personnel; Hispanic Americans; Sex Differences; Racial Differences; Black Americans; United States of America ER - TY - JOUR T1 - A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect. AN - 85252319; pmid-9024173 AB - BACKGROUND: The effects of anesthetic drugs on electroencephalograms (EEG) have been studied to develop the EEG as a measure of anesthetic depth. Bispectral analysis is a new quantitative technique that measures the consistency of the phase and power relationships and returns a single measure, the bispectral index. The purpose of this study was to compare the performance of the bispectral index, version 1.1, with other spectral analysis EEG measures of drug effect for three commonly used anesthetic drugs. METHODS: The EEG waveforms from 31 adults receiving infusions of alfentanil, propofol, or midazolam were analyzed. The time course of spectral edge (SE95), relative power in delta band, and bispectral index were related to the estimated effect-site concentration with use of a sigmoidal Emax model to estimate the potency (IC50) and the plasma effect-site equilibration rate constant (Ke0) for each measure. The performance of the fitting was assessed by the coefficient of correlation between predicted and observed effect. RESULTS: Alfentanil induced a high-amplitude low-frequency EEG response. Propofol induced a biphasic response. At low concentrations, both frequency and amplitude increased. When the concentration increased, the EEG slowed and the amplitude decreased. High concentration produced burst suppression. Midazolam increased EEG frequency and amplitude. Bispectral index, SE95, and delta power yield similar estimates of IC50 and ke0. Except for alfentanil, the performance of the modeling with the bispectral index was as good that with SE95 or delta power. CONCLUSION: Bispectral analysis can be used as a measure of the EEG effects of anesthetic drugs. JF - Clinical Pharmacology and Therapeutics AU - Billard, V AU - Gambus, P L AU - Chamoun, N AU - Stanski, D R AU - Shafer, S L AD - Palo Alto Veterans Administration Medical Center, Calif, USA. PY - 1997 SP - 45 EP - 58 VL - 61 IS - 1 SN - 0009-9236, 0009-9236 KW - Anesthetics, Intravenous KW - Human KW - Electroencephalography KW - Retrospective Studies KW - Aged KW - Alfentanil KW - Midazolam KW - Comparative Study KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Middle Age KW - Support, Non-U.S. Gov't KW - Propofol KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85252319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Pharmacology+and+Therapeutics&rft.atitle=A+comparison+of+spectral+edge%2C+delta+power%2C+and+bispectral+index+as+EEG+measures+of+alfentanil%2C+propofol%2C+and+midazolam+drug+effect.&rft.au=Billard%2C+V%3BGambus%2C+P+L%3BChamoun%2C+N%3BStanski%2C+D+R%3BShafer%2C+S+L&rft.aulast=Billard&rft.aufirst=V&rft.date=1997-01-01&rft.volume=61&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Clinical+Pharmacology+and+Therapeutics&rft.issn=00099236&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Parenting influences on the development of alcohol abuse and dependence. AN - 79649993; 15706770 AB - Both alcohol-specific and non-alcohol-specific parenting influences affect the development of alcohol abuse and dependence in the offspring. Alcohol-specific influences (e.g., the modeling of parental drinking behavior, the development of alcohol expectancies, and certain aspects of the parent-child relationship) are particularly relevant to the development of alcohol abuse and dependence in children of alcoholics. In contrast, non-alcohol-specific influences generally promote deviant behavior, including alcohol problems, in the offspring and affect children of alcoholics and nonalcoholics equally. These influences, which include inadequate parenting and other parent-child interaction patterns that promote aggressive, antisocial behavior in children, increase the offspring's risk of an alcoholism subtype associated with antisocial personality disorder. A different set of non-alcohol-specific family influences may contribute to an alcoholism subtype that emerges after the onset of depression. JF - Alcohol health and research world AU - Jacob, T AU - Johnson, S AD - Palo Alto Veterans Administration Health Care System, Palo Alto, California, USA. Y1 - 1997 PY - 1997 DA - 1997 SP - 204 EP - 209 VL - 21 IS - 3 SN - 0090-838X, 0090-838X KW - Index Medicus KW - Humans KW - Child KW - Sibling Relations KW - Alcoholism -- epidemiology KW - Parenting -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79649993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+health+and+research+world&rft.atitle=Parenting+influences+on+the+development+of+alcohol+abuse+and+dependence.&rft.au=Jacob%2C+T%3BJohnson%2C+S&rft.aulast=Jacob&rft.aufirst=T&rft.date=1997-01-01&rft.volume=21&rft.issue=3&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Alcohol+health+and+research+world&rft.issn=0090838X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-03-17 N1 - Date created - 2005-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of endothelial cell injury by cigarette smoke. AN - 79594444; 9588817 AB - Cigarette smoke contains different populations of free radicals which may be responsible for endothelial cell (EC) injury of smokers. The purpose of this study was to examine the effects of gas-phase cigarette smoke on EC endothelium-derived relaxing factor (EDRF)/NO-guanylate cyclase (GC)-cGMP pathway and on EC detachment-type injury after incubation with smoke. Furthermore, we examined whether different kind of antioxidants can prevent smoke-caused EC injury. We measured cGMP pathway using direct (sodium nitroprusside, SNP) and indirect (A23187, the calcium ionophore and bradykinin, BK) activators of GC. Directly and indirectly stimulated EC cGMP production dose-dependently decreased and EC detachment increased after incubation with smoke. Externally added thiols (glutathione, GSH; D-Penicillamine, DP; N-acetylcysteine, NAC) protected EC from damage of cGMP production and cell detachment. Other antioxidants (catalase, deferoxamine and superoxide dismutase) were ineffective. These results suggest that the thiol containing GC in EC is destroyed or inactivated or thiol like species responsible for activation of GC is incomplete in EC after incubation with smoke. It is also possible that externally added thiols bind an unknown component of smoke and this way, EC is protected. EC injury may contribute to vascular diseases associated with cigarette smoking. JF - Endothelium : journal of endothelial cell research AU - Nagy, J AU - Demaster, E G AU - Wittmann, I AU - Shultz, P AU - Raij, L AD - University of Minnesota, School of Medicine and Veterans Administration Medical Center, Minneapolis 55417, USA. Y1 - 1997 PY - 1997 DA - 1997 SP - 251 EP - 263 VL - 5 IS - 4 SN - 1062-3329, 1062-3329 KW - Antioxidants KW - 0 KW - Free Radicals KW - Gases KW - Ionophores KW - Smoke KW - Sulfhydryl Compounds KW - Nitroprusside KW - 169D1260KM KW - Formaldehyde KW - 1HG84L3525 KW - Nitric Oxide KW - 31C4KY9ESH KW - Calcimycin KW - 37H9VM9WZL KW - Guanylate Cyclase KW - EC 4.6.1.2 KW - Glutathione KW - GAN16C9B8O KW - Cyclic GMP KW - H2D2X058MU KW - Bradykinin KW - S8TIM42R2W KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Swine KW - Animals KW - Dose-Response Relationship, Drug KW - Sulfhydryl Compounds -- pharmacology KW - Glutathione -- metabolism KW - Aorta KW - Nitric Oxide -- metabolism KW - Calcimycin -- pharmacology KW - Formaldehyde -- analysis KW - Guanylate Cyclase -- metabolism KW - Cyclic GMP -- metabolism KW - Ionophores -- pharmacology KW - Antioxidants -- pharmacology KW - Cells, Cultured KW - Calcium -- physiology KW - Bradykinin -- pharmacology KW - Nitroprusside -- pharmacology KW - Cell Adhesion -- drug effects KW - Plants, Toxic KW - Smoke -- adverse effects KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Endothelium, Vascular -- pathology KW - Smoke -- analysis KW - Tobacco -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79594444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endothelium+%3A+journal+of+endothelial+cell+research&rft.atitle=Induction+of+endothelial+cell+injury+by+cigarette+smoke.&rft.au=Nagy%2C+J%3BDemaster%2C+E+G%3BWittmann%2C+I%3BShultz%2C+P%3BRaij%2C+L&rft.aulast=Nagy&rft.aufirst=J&rft.date=1997-01-01&rft.volume=5&rft.issue=4&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Endothelium+%3A+journal+of+endothelial+cell+research&rft.issn=10623329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-07-16 N1 - Date created - 1998-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Overview of potential treatment medications for cocaine dependence. AN - 79561183; 9467792 JF - NIDA research monograph AU - McCance, E F AD - Veterans Administration Connecticut Health Care System, West Haven 06516, USA. Y1 - 1997 PY - 1997 DA - 1997 SP - 36 EP - 72 VL - 175 SN - 1046-9516, 1046-9516 KW - Dopamine Agents KW - 0 KW - Narcotics KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Dopamine Agents -- therapeutic use KW - Humans KW - Substance-Related Disorders -- drug therapy KW - Cocaine -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79561183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Overview+of+potential+treatment+medications+for+cocaine+dependence.&rft.au=McCance%2C+E+F&rft.aulast=McCance&rft.aufirst=E&rft.date=1997-01-01&rft.volume=175&rft.issue=&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-03-17 N1 - Date created - 1998-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phenotypic characterization of mononuclear cells from gingiva associated with periodontitis and peri-implantitis. AN - 79559915; 9477856 AB - The purpose of this study was to compare the phenotypic distribution of resident gingival mononuclear inflammatory cells from tissues associated with peri-implantitis and periodontitis. Inflamed gingiva was obtained from six patients during surgical removal of failed dental implants. Similarly, inflamed gingiva around teeth was obtained from eight patients with moderate to advanced periodontitis. Monoclonal antibodies were used to identify membrane antigens from CD4+ T-lymphocytes, CD4+/CD8(+)-activated T-lymphocytes, tissue macrophages, CD20+ B-lymphocytes, and MHC class II (Ia) antigens. Gingival inflammation associated with both dental implants and natural teeth was characterized by substantial numbers of CD4+ T-lymphocytes, resident macrophages, and B-lymphocytes. In addition, there was an abundance of HLA class II-positive mononuclear cells throughout most specimens. These results suggest that the gingival mononuclear inflammatory response in peri-implantitis and periodontitis is similar and support the hypothesis that similar inflammatory mechanisms are associated with both conditions. JF - The Journal of oral implantology AU - Talarico, G M AU - Neiders, M E AU - Comeau, R L AU - Cohen, R E AD - Veterans Administration Medical Center, Buffalo, NY, USA. Y1 - 1997 PY - 1997 DA - 1997 SP - 5 EP - 11 VL - 23 IS - 1-2 SN - 0160-6972, 0160-6972 KW - Antigens, CD20 KW - 0 KW - Dental Implants KW - Histocompatibility Antigens Class II KW - Dentistry KW - AIDS/HIV KW - Macrophages -- immunology KW - Humans KW - Adult KW - Dental Restoration Failure KW - Middle Aged KW - Histocompatibility Antigens Class II -- immunology KW - CD4-CD8 Ratio KW - Immunophenotyping KW - Female KW - Antigens, CD20 -- immunology KW - Gingiva -- immunology KW - Leukocytes, Mononuclear -- immunology KW - Periodontitis -- etiology KW - Periodontitis -- immunology KW - Dental Implants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79559915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+oral+implantology&rft.atitle=Phenotypic+characterization+of+mononuclear+cells+from+gingiva+associated+with+periodontitis+and+peri-implantitis.&rft.au=Talarico%2C+G+M%3BNeiders%2C+M+E%3BComeau%2C+R+L%3BCohen%2C+R+E&rft.aulast=Talarico&rft.aufirst=G&rft.date=1997-01-01&rft.volume=23&rft.issue=1-2&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+oral+implantology&rft.issn=01606972&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-03-17 N1 - Date created - 1998-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment effectiveness score as an outcome measure in clinical trials. AN - 79556270; 9467800 JF - NIDA research monograph AU - Ling, W AU - Shoptaw, S AU - Wesson, D AU - Rawson, R A AU - Compton, M AU - Klett, C J AD - West Los Angeles Veterans Administration Medical Center, CA 90073, USA. Y1 - 1997 PY - 1997 DA - 1997 SP - 208 EP - 220 VL - 175 SN - 1046-9516, 1046-9516 KW - Narcotics KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Humans KW - Substance-Related Disorders -- drug therapy KW - Outcome Assessment (Health Care) KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79556270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NIDA+research+monograph&rft.atitle=Treatment+effectiveness+score+as+an+outcome+measure+in+clinical+trials.&rft.au=Ling%2C+W%3BShoptaw%2C+S%3BWesson%2C+D%3BRawson%2C+R+A%3BCompton%2C+M%3BKlett%2C+C+J&rft.aulast=Ling&rft.aufirst=W&rft.date=1997-01-01&rft.volume=175&rft.issue=&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=NIDA+research+monograph&rft.issn=10469516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-03-17 N1 - Date created - 1998-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The use of risperidone for psychosis and agitation in demented patients with Parkinson's disease. AN - 79537570; 9447503 AB - This pilot study investigated effectiveness and tolerability of risperidone for the treatment of psychosis and agitation in 9 inpatients with Parkinson's disease and dementia. Investigators found risperidone to be effective and safe, without worsening extrapyramidal symptoms or further impairing cognition. JF - The Journal of neuropsychiatry and clinical neurosciences AU - Workman, R H AU - Orengo, C A AU - Bakey, A A AU - Molinari, V A AU - Kunik, M E AD - Veterans Affairs Medical Center, Houston, Texas 77030, USA. workman.richardvhvjr@houston.va.gov Y1 - 1997 PY - 1997 DA - 1997 SP - 594 EP - 597 VL - 9 IS - 4 SN - 0895-0172, 0895-0172 KW - Antipsychotic Agents KW - 0 KW - Risperidone KW - L6UH7ZF8HC KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Humans KW - Aged KW - Pilot Projects KW - Male KW - Female KW - Psychomotor Agitation -- drug therapy KW - Psychomotor Agitation -- psychology KW - Dementia -- psychology KW - Antipsychotic Agents -- therapeutic use KW - Psychomotor Agitation -- etiology KW - Dementia -- complications KW - Parkinson Disease -- complications KW - Risperidone -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Risperidone -- therapeutic use KW - Parkinson Disease -- psychology KW - Dementia -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79537570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuropsychiatry+and+clinical+neurosciences&rft.atitle=The+use+of+risperidone+for+psychosis+and+agitation+in+demented+patients+with+Parkinson%27s+disease.&rft.au=Workman%2C+R+H%3BOrengo%2C+C+A%3BBakey%2C+A+A%3BMolinari%2C+V+A%3BKunik%2C+M+E&rft.aulast=Workman&rft.aufirst=R&rft.date=1997-01-01&rft.volume=9&rft.issue=4&rft.spage=594&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuropsychiatry+and+clinical+neurosciences&rft.issn=08950172&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-03-05 N1 - Date created - 1998-03-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Neuropsychiatry Clin Neurosci. 1998 Fall;10(4):473-5 [9813797] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of hydroxyl radical (OH.) on sphincter of Oddi motility. AN - 79441243; 9383636 AB - Antioxidant enzymes are present in sphincter of Oddi nerves and regulate sphincter of Oddi motor function mediated by NO-releasing nerves. Oxygen free radicals (O2-.) produce hydrogen peroxide (H2O2) by the action of superoxide dismutase (SOD). Hydroxyl radical (OH.) has been shown to play an important role as a mediator of H2O2 toxicity. The aims of our study were to determine the effects of H2O2 on sphincter of Oddi motility and if these effects are mediated by OH.. Adult opossums were sacrificed and the sphincter of Oddi removed and placed in a tissue bath containing oxygenated Krebs solution. Force transducers recorded tension in a transverse orientation at two sites along the sphincter of Oddi specimen. H2O2 was added into the tissue bath at concentrations from 0.01 to 0.5%. O2-. radicals were inhibited by the addition of SOD, while OH. was scavenged by the addition of alcohol (ETOH) or dimethyl sulfoxide (DMSO). H2O2 produced a dose-dependent increase in baseline amplitude, frequency, and peak amplitude of contractions. The effect of 0.01% H2O2 on sphincter of Oddi contractile frequency was inhibited by 0.2% ETOH and DMSO, but not by SOD. We conclude that H2O2 has profound effects on sphincter of Oddi motility and that the actions of H2O2 are probably mediated through OH.. JF - Digestion AU - Cullen, J J AU - Ledlow, A AU - Murray, J A AU - Conklin, J L AD - Surgical Service, Veterans Administration Medical Center, Iowa City, Iowa, USA. Y1 - 1997 PY - 1997 DA - 1997 SP - 452 EP - 457 VL - 58 IS - 5 SN - 0012-2823, 0012-2823 KW - Free Radical Scavengers KW - 0 KW - Hydroxyl Radical KW - 3352-57-6 KW - Ethanol KW - 3K9958V90M KW - Hydrogen Peroxide KW - BBX060AN9V KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Index Medicus KW - Dimethyl Sulfoxide -- pharmacology KW - Animals KW - Superoxide Dismutase -- pharmacology KW - Ethanol -- pharmacology KW - Dose-Response Relationship, Drug KW - Muscle Contraction -- drug effects KW - Male KW - Free Radical Scavengers -- pharmacology KW - Female KW - Opossums KW - Hydrogen Peroxide -- pharmacology KW - Hydroxyl Radical -- pharmacology KW - Sphincter of Oddi -- drug effects KW - Sphincter of Oddi -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79441243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestion&rft.atitle=Effect+of+hydroxyl+radical+%28OH.%29+on+sphincter+of+Oddi+motility.&rft.au=Cullen%2C+J+J%3BLedlow%2C+A%3BMurray%2C+J+A%3BConklin%2C+J+L&rft.aulast=Cullen&rft.aufirst=J&rft.date=1997-01-01&rft.volume=58&rft.issue=5&rft.spage=452&rft.isbn=&rft.btitle=&rft.title=Digestion&rft.issn=00122823&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-01-02 N1 - Date created - 1998-01-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effects of opiates on the lung. AN - 79392219; 9358989 JF - Clinical reviews in allergy & immunology AU - Lao, P N AD - Division of Critical Care Medicine, West Palm Beach VAMC, FL 33410, USA. Lao.Paul_N@West-Palm.Va.Gov Y1 - 1997 PY - 1997 DA - 1997 SP - 291 EP - 305 VL - 15 IS - 3 SN - 1080-0549, 1080-0549 KW - Narcotics KW - 0 KW - Index Medicus KW - Humans KW - Lung Diseases -- chemically induced KW - Opioid-Related Disorders -- complications KW - Narcotics -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79392219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+reviews+in+allergy+%26+immunology&rft.atitle=The+effects+of+opiates+on+the+lung.&rft.au=Lao%2C+P+N&rft.aulast=Lao&rft.aufirst=P&rft.date=1997-01-01&rft.volume=15&rft.issue=3&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Clinical+reviews+in+allergy+%26+immunology&rft.issn=10800549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-12-31 N1 - Date created - 1997-12-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Personal construct psychotherapy of addictions. AN - 79120856; 9218235 AB - Personal construct psychotherapy and its utility in understanding and treating addictions is explored. Several clinical phenomena related to chemical dependency are discussed from the perspective of constructivism. Framed within the context of Prochaska, DiClemente, & Norcross' (1992) stages of change model, several psychotherapeutic techniques are outlined. These concepts and techniques are offered as theoretically based heuristics and are intended to illustrate the potential utility of a clinical approach based upon personal construct theory. JF - Journal of substance abuse treatment AU - Klion, R E AU - Pfenninger, D T AD - Psychology Service, Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA. PY - 1997 SP - 37 EP - 43 VL - 14 IS - 1 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Psychological Theory KW - Humans KW - Interpersonal Relations KW - Role KW - Self Concept KW - Behavior, Addictive -- psychology KW - Psychotherapy -- methods KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79120856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Personal+construct+psychotherapy+of+addictions.&rft.au=Klion%2C+R+E%3BPfenninger%2C+D+T&rft.aulast=Klion&rft.aufirst=R&rft.date=1997-01-01&rft.volume=14&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-09-04 N1 - Date created - 1997-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Increased risk in esophageal obstruction with slow-release medications. AN - 79043370; 9167415 AB - Although medication-induced (pill) esophagitis has been recognized for a long time, little data are available on the risk of recently introduced slow-release medications. These formulations may have an obstructive capability (undissolved medication blocking an obstructed lumen) or may cause tissue irritation (continuous leakage from a slowly disintegrating pill). We observed a patient with esophageal carcinoma who developed complete obstruction when three Procardia XL (nifedipine) extended-release tablets blocked the narrowed lumen. An intact Procardia XL tablet and a washed shell as a control were implanted subcutaneously in a rat. The intact pill produced a large inflammatory mass: in contrast, no inflammatory response was noted at the control site implanted with a washed shell. In vitro testing of seven different slow-release medications revealed a wide difference in their solubility at a neutral pH and in gastric juice of pH 1.8 (simulation of esophageal or gastric environment). Theolair-SR (anhydrous theophylline, sustained-release) tablets had the highest obstructive, but no irritating potential. Cardizem SR (diltiazem hydrochloride) sustained-release capsules dissolved promptly without obstructive potential. Adalat CC (nifedipine) extended-release tablets also dissolved early at both pH values. Cardizem CD (diltiazem hydrochloride) extended-release capsules and Calan SR (verapamil hydrochloride) sustained-release oral caplets disintegrated into granules that had a low obstructive potential, but their prolonged presence increased the risk of tissue irritation. Ecotrin (enteric-coated aspirin) tablets had a high obstructive and no irritating potential in the first 24 hours, after which they disintegrated and directly contacted the tissue. Procardia XL extended-release tablets had an insoluble shell that continued to leak a tissue-irritating content even after 48 hours, generating a prolonged obstructive and irritating condition. In conclusion, slow-release medications greatly increase the risk of esophageal injury. Their obstructive and tissue-irritating potentials differ widely. Slow-release formulations should be contraindicated in patients who have obstructive esophageal and gastric disorders. JF - Journal of the Association for Academic Minority Physicians : the official publication of the Association for Academic Minority Physicians AU - Simko, V AU - Joseph, D AU - Michael, S AD - Section of Gastroenterology, Brooklyn Veterans Administration Medical Center, NY 11209, USA. Y1 - 1997 PY - 1997 DA - 1997 SP - 38 EP - 42 VL - 8 IS - 2 SN - 1048-9886, 1048-9886 KW - Delayed-Action Preparations KW - 0 KW - Nifedipine KW - I9ZF7L6G2L KW - Index Medicus KW - Animals KW - Drug Stability KW - Fatal Outcome KW - Delayed-Action Preparations -- adverse effects KW - Humans KW - Hydrogen-Ion Concentration KW - Skin -- pathology KW - Aged KW - Disease Models, Animal KW - Gastric Juice -- drug effects KW - Rats KW - In Vitro Techniques KW - Carcinoma, Squamous Cell -- drug therapy KW - Male KW - Esophageal Neoplasms -- drug therapy KW - Esophagus KW - Esophageal Stenosis -- diagnosis KW - Nifedipine -- administration & dosage KW - Esophageal Stenosis -- chemically induced KW - Foreign Bodies -- etiology KW - Nifedipine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/79043370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Association+for+Academic+Minority+Physicians+%3A+the+official+publication+of+the+Association+for+Academic+Minority+Physicians&rft.atitle=Increased+risk+in+esophageal+obstruction+with+slow-release+medications.&rft.au=Simko%2C+V%3BJoseph%2C+D%3BMichael%2C+S&rft.aulast=Simko&rft.aufirst=V&rft.date=1997-01-01&rft.volume=8&rft.issue=2&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Association+for+Academic+Minority+Physicians+%3A+the+official+publication+of+the+Association+for+Academic+Minority+Physicians&rft.issn=10489886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-06-19 N1 - Date created - 1997-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Focus formation of C3H/10T1/2 cells and exposure to a 836.55 MHz modulated radiofrequency field. AN - 78903752; 9096842 AB - Disruption of communication between transformed cells and normal cells is involved in tumor promotion. We have tested the hypothesis that exposures to radiofrequency (RF) fields using a form of digital modulation (TDMA) and a chemical tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), are copromoters that enhance focus formation of transformed cells in coculture with parental C3H/10T1/2 murine fibroblasts. RF field exposures did not influence TPA's dose-dependent promotion of focus formation in coculture. Cell cultures were exposed to an 836.55 MHz TDMA-modulated field in TEM transmission line chambers, with incident energies that simulated field intensities at a user's head. Specific absorption rates (SARs) of 0.15, 1.5, and 15 muW/g were used during each digital packet, and the packet frequency was 50/s. The TEM chambers were placed in a commercial incubator at 37 degrees C and 95% humidity/5% CO2. The RF field exposures were in a repeating cycle, 20 min on, 20 min off, 24 h/day for 28 days. At 1.5 muW/g, TPA-induced focus formation (at 10, 30, and 50 ng/ml) was not significantly different in RF-exposed cultures compared to parallel sham-exposed cultures in ten independent experiments in terms of the number, density, and area of foci. Similarly, at 0.15 and 15.0 muW/g, in two and four experiments, respectively, RF exposure did not alter TPA-induced focus formation. The findings support a conclusion that repeated exposures to this RF field do not influence tumor promotion in vitro, based on the RF field's inability to enhance TPA-induced focus formation. JF - Bioelectromagnetics AU - Cain, C D AU - Thomas, D L AU - Adey, W R AD - Jerry L. Pettis Memorial Veterans Administration Medical Center, Loma Linda, California 92357, USA. Y1 - 1997 PY - 1997 DA - 1997 SP - 237 EP - 243 VL - 18 IS - 3 SN - 0197-8462, 0197-8462 KW - Carcinogens KW - 0 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Tetradecanoylphorbol Acetate -- toxicity KW - Coculture Techniques KW - Animals KW - Analysis of Variance KW - Microscopy, Video KW - Dose-Response Relationship, Drug KW - Mice, Inbred C3H KW - Carcinogens -- toxicity KW - Mice KW - Cell Line KW - Fibroblasts KW - Radio Waves KW - Electromagnetic Fields KW - Cell Transformation, Neoplastic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78903752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioelectromagnetics&rft.atitle=Focus+formation+of+C3H%2F10T1%2F2+cells+and+exposure+to+a+836.55+MHz+modulated+radiofrequency+field.&rft.au=Cain%2C+C+D%3BThomas%2C+D+L%3BAdey%2C+W+R&rft.aulast=Cain&rft.aufirst=C&rft.date=1997-01-01&rft.volume=18&rft.issue=3&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Bioelectromagnetics&rft.issn=01978462&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-06-09 N1 - Date created - 1997-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Paracellular phosphate absorption in rat colon: a mechanism for enema-induced hyperphosphatemia. AN - 78866677; 9058363 AB - The mechanism of colonic phosphate absorption is not well defined. We measured unidirectional phosphate fluxes across rat distal colon epithelium in the absence of transepithelial electrochemical gradients. Steady-state mucosal-to-serosal flux (Jms) was not different from the serosal-to-mucosal flux (Jsm), generating no net flux (Jnet = Jms - Jsm, was not different from "0'). Simultaneous fluxes of mannitol, a paracellular probe, exhibited an identical flux pattern, suggesting that phosphate flux across the colonic epithelium may be mediated through the paracellular pathway. Tight junction permeability was increased with mucosal addition of taurodeoxycholate (TDC, 2 mM) which caused a prompt increase in transepithelial conductance from 7.03 +/- 0.35 to 13.88 +/- 0.35 mS/cm2 (p < 0.001). This was associated with an increase in Jsm, but no change in Jms, for mannitol, resulting in a net flux in the secretary direction. Identical TDC-induced changes were observed in phosphate fluxes, again suggesting phosphate permeation through the intercellular, mannitol pathway. A significant correlation was observed between the permeability of phosphate and the permeability of mannitol, measured both in the mucosal-to-serosal and the serosal-to-mucosal directions and under both control and experimental (mucosal TDC) conditions. Thus, colonic phosphate transport is mediated through the paracellular pathway and enema with high phosphate concentrations (1,760 times blood concentration), can trigger rapid and massive phosphate absorption through this diffusive pathway. JF - Mineral and electrolyte metabolism AU - Hu, M S AU - Kayne, L H AU - Jamgotchian, N AU - Ward, H J AU - Lee, D B AD - Medical and Research Services, Veterans Health Administration Medical Center, Sepulveda, Calif., USA. Y1 - 1997 PY - 1997 DA - 1997 SP - 7 EP - 12 VL - 23 IS - 1 SN - 0378-0392, 0378-0392 KW - Phosphates KW - 0 KW - Mannitol KW - 3OWL53L36A KW - Taurodeoxycholic Acid KW - 516-50-7 KW - Index Medicus KW - Rats KW - Permeability KW - Animals KW - Rats, Wistar KW - Taurodeoxycholic Acid -- pharmacology KW - Male KW - Tight Junctions -- metabolism KW - Mannitol -- pharmacokinetics KW - Phosphates -- pharmacokinetics KW - Phosphates -- blood KW - Colon -- metabolism KW - Intestinal Absorption KW - Enema -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78866677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mineral+and+electrolyte+metabolism&rft.atitle=Paracellular+phosphate+absorption+in+rat+colon%3A+a+mechanism+for+enema-induced+hyperphosphatemia.&rft.au=Hu%2C+M+S%3BKayne%2C+L+H%3BJamgotchian%2C+N%3BWard%2C+H+J%3BLee%2C+D+B&rft.aulast=Hu&rft.aufirst=M&rft.date=1997-01-01&rft.volume=23&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Mineral+and+electrolyte+metabolism&rft.issn=03780392&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-09 N1 - Date created - 1997-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug-induced lung disease. AN - 78827572; 9048121 AB - Pulmonary reactions to drugs are a significant clinical problem and serve as a model for lung injury owing to other causes. Pulmonary reactions to certain drugs, such as bleomycin, carmustine, and amiodarone, greatly limit the use of these drugs. If research can distinguish the toxic from the therapeutic mechanisms of these and other drugs perhaps more effective therapies can be designed. JF - Advances in internal medicine AU - Copper, J A AD - Pulmonary Section, Birmingham Veterans Administration Medical Center, Alabama, USA. Y1 - 1997 PY - 1997 DA - 1997 SP - 231 EP - 268 VL - 42 SN - 0065-2822, 0065-2822 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Diagnosis, Differential KW - Syndrome KW - Humans KW - Bronchial Spasm -- chemically induced KW - Antineoplastic Agents -- adverse effects KW - Lung Diseases, Interstitial -- diagnosis KW - Lung Diseases, Interstitial -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78827572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+internal+medicine&rft.atitle=Drug-induced+lung+disease.&rft.au=Copper%2C+J+A&rft.aulast=Copper&rft.aufirst=J&rft.date=1997-01-01&rft.volume=42&rft.issue=&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Advances+in+internal+medicine&rft.issn=00652822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-01 N1 - Date created - 1997-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol and cocaine interactions and aggressive behaviors. AN - 78815267; 9122499 AB - This chapter presents (1) a review of several studies on the relationship between violent/aggressive behavior and the use of cocaine and/or the use of alcohol; and (2) findings from our study of cocaine-dependent men, illustrating deviant and violent behavior before and during cocaine addiction careers. As had been found in previous research, use of alcohol and cocaine seemed to increase the likelihood of the cocaine users in our sample engaging in deviant or violent behaviors. The extent of deviant or violent behavior, in our sample, during periods of cocaine use, periods of cocaine-alcohol use, periods of alcohol use only, and periods of abstinence for both alcohol and cocaine are discussed. Changes in the nature of the deviant or violent behaviors prior to and after the onset of cocaine addiction are also described. JF - Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism AU - Denison, M E AU - Paredes, A AU - Booth, J B AD - Laboratory for the Study of Addictions, West Los Angeles Veterans Administration, California 90073, USA. Y1 - 1997 PY - 1997 DA - 1997 SP - 283 EP - 303 VL - 13 SN - 0738-422X, 0738-422X KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Causality KW - Patient Admission KW - Sex Factors KW - Humans KW - Veterans -- psychology KW - Alcohol Drinking -- adverse effects KW - Retrospective Studies KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Alcoholic Intoxication -- rehabilitation KW - Opioid-Related Disorders -- epidemiology KW - Alcoholic Intoxication -- psychology KW - Alcoholic Intoxication -- epidemiology KW - Violence -- statistics & numerical data KW - Opioid-Related Disorders -- psychology KW - Aggression -- psychology KW - Violence -- prevention & control KW - Opioid-Related Disorders -- rehabilitation KW - Cocaine -- adverse effects KW - Violence -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78815267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Recent+developments+in+alcoholism+%3A+an+official+publication+of+the+American+Medical+Society+on+Alcoholism%2C+the+Research+Society+on+Alcoholism%2C+and+the+National+Council+on+Alcoholism&rft.atitle=Alcohol+and+cocaine+interactions+and+aggressive+behaviors.&rft.au=Denison%2C+M+E%3BParedes%2C+A%3BBooth%2C+J+B&rft.aulast=Denison&rft.aufirst=M&rft.date=1997-01-01&rft.volume=13&rft.issue=&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Recent+developments+in+alcoholism+%3A+an+official+publication+of+the+American+Medical+Society+on+Alcoholism%2C+the+Research+Society+on+Alcoholism%2C+and+the+National+Council+on+Alcoholism&rft.issn=0738422X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-04-22 N1 - Date created - 1997-04-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Medications that may contribute to sexual disorders. A guide to assessment and treatment in family practice. AN - 78805906; 9010369 AB - Approximately 15% to 25% of family practice patients have concerns about sexual function and are most comfortable discussing these issues with their family physician. While many physicians have avoided this topic in the past, citing lack of knowledge and skill, the family practice setting is ideal for a preliminary evaluation of sexual dysfunction and treatment for certain etiologies. This especially is true for changes in sexual function secondary to medication effects. This article provides basic guidelines designed to assist physicians in evaluating the effects of medications and other substances on sexual function. Also included are lists of medications known or suspected to have adverse effects on sexual function. Physicians are encouraged to address the sexual concerns of their patients and to incorporate these guidelines and the medication lists into their evaluation. JF - The Journal of family practice AU - Finger, W W AU - Lund, M AU - Slagle, M A AD - Mountain Home Veterans Affairs Medical Center, Johnson City, Tennessee, USA. finger.william@mtn-home.va.gov Y1 - 1997/01// PY - 1997 DA - January 1997 SP - 33 EP - 43 VL - 44 IS - 1 SN - 0094-3509, 0094-3509 KW - Antihypertensive Agents KW - 0 KW - Nonprescription Drugs KW - Psychotropic Drugs KW - Street Drugs KW - Abridged Index Medicus KW - Index Medicus KW - Nonprescription Drugs -- adverse effects KW - Humans KW - Street Drugs -- adverse effects KW - Antihypertensive Agents -- adverse effects KW - Substance-Related Disorders -- complications KW - Psychotropic Drugs -- adverse effects KW - Family Practice KW - Sexual Dysfunction, Physiological -- etiology KW - Sexual Dysfunction, Physiological -- therapy KW - Sexual Dysfunction, Physiological -- chemically induced KW - Sexual Dysfunction, Physiological -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78805906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+family+practice&rft.atitle=Medications+that+may+contribute+to+sexual+disorders.+A+guide+to+assessment+and+treatment+in+family+practice.&rft.au=Finger%2C+W+W%3BLund%2C+M%3BSlagle%2C+M+A&rft.aulast=Finger&rft.aufirst=W&rft.date=1997-01-01&rft.volume=44&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+family+practice&rft.issn=00943509&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-02-19 N1 - Date created - 1997-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of Taxol on cytochrome P450 3A and acetaminophen toxicity in cultured rat hepatocytes: comparison to dexamethasone. AN - 78803186; 9007036 AB - The purpose of this study was to determine if Taxol induced CYP3A in primary cultures of rat hepatocytes and, if so, whether induction of CYP3A would increase acetaminophen toxicity. Taxol caused a concentration-dependent increase in the amount of immunoreactive CYP3A and in the steady-state levels of CYP3A1/DEX but not CYP3A2 mRNA. Similar concentration-dependent increases in toxicity as measured by a decrease in protein synthesis were observed after exposure of cells to acetaminophen for 7 hr whether cells were pretreated with Taxol or dexamethasone. Increased release of lactate dehydrogenase occured after 24 hr exposure to acetaminophen, with no further decreases in protein synthesis than those observed at 7 hr. Increases in acetaminophen toxicity correlated with increased covalent binding of acetaminophen to cellular proteins. Triacetyloleandomycin, a selective inhibitor of CYP3A, completely protected the cells against acetaminophen toxicity in both Taxol- and dexamethasone-pretreated cells and prevented the increase in covalent binding of acetaminophen to cellular proteins. These results demonstrate that Taxol, like dexamethasone, induces CYP3A and that increases in this P450 are responsible for increased acetaminophen toxicity. JF - Toxicology and applied pharmacology AU - Kostrubsky, V E AU - Lewis, L D AU - Wood, S G AU - Sinclair, P R AU - Wrighton, S A AU - Sinclair, J F AD - Veterans Administration Medical Center, White River Junction, Vermont 05009, USA. Y1 - 1997/01// PY - 1997 DA - January 1997 SP - 79 EP - 86 VL - 142 IS - 1 SN - 0041-008X, 0041-008X KW - Cytochrome P-450 Enzyme Inhibitors KW - 0 KW - Enzyme Inhibitors KW - RNA, Messenger KW - Acetaminophen KW - 362O9ITL9D KW - Dexamethasone KW - 7S5I7G3JQL KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Troleandomycin KW - C4DZ64560D KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Cyp3a1 protein, rat KW - Cytochrome P-450 CYP3A KW - Oxidoreductases, N-Demethylating KW - EC 1.5.- KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Troleandomycin -- pharmacology KW - Enzyme Induction -- drug effects KW - Dexamethasone -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Drug Synergism KW - RNA, Messenger -- biosynthesis KW - Male KW - Biotransformation -- drug effects KW - Oxidoreductases, N-Demethylating -- genetics KW - Acetaminophen -- pharmacokinetics KW - Liver -- enzymology KW - Cytochrome P-450 Enzyme System -- genetics KW - Cytochrome P-450 Enzyme System -- biosynthesis KW - Cytochrome P-450 Enzyme System -- metabolism KW - Paclitaxel -- pharmacology KW - Oxidoreductases, N-Demethylating -- biosynthesis KW - Liver -- drug effects KW - Oxidoreductases, N-Demethylating -- antagonists & inhibitors KW - Oxidoreductases, N-Demethylating -- metabolism KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78803186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Effect+of+Taxol+on+cytochrome+P450+3A+and+acetaminophen+toxicity+in+cultured+rat+hepatocytes%3A+comparison+to+dexamethasone.&rft.au=Kostrubsky%2C+V+E%3BLewis%2C+L+D%3BWood%2C+S+G%3BSinclair%2C+P+R%3BWrighton%2C+S+A%3BSinclair%2C+J+F&rft.aulast=Kostrubsky&rft.aufirst=V&rft.date=1997-01-01&rft.volume=142&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-02-24 N1 - Date created - 1997-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Protection of ethanol-mediated acetaminophen hepatotoxicity by triacetyloleandomycin, a specific inhibitor of CYP3A. AN - 78786029; 8997458 AB - Cytochrome P450 2E (CYP2E) is considered responsible for ethanol-mediated increases in acetaminophen (APAP) hepatotoxicity. However, it has been shown in cultured human and rat hepatocytes and intact rats that ethanol induces CYP3A in addition to CYP2E. Therefore, an investigation was made in rats to see whether or not an inhibitor of CYP3A, triacetyloleandomycin (TAO), would protect against ethanol-mediated increases in APAP hepatotoxicity. Rats, treated with 6.3 percent ethanol in the Lieber-DeCarli diet for 7 days, were administered APAP (lg/kg, i.g.) 11 hrs after removal of the diet. Triacetyloleandomycin (500 mg/kg, saline solution) was injected i.p. 2 hrs before the administration of APAP. In rats pretreated with ethanol, treatment with APAP for 7 hrs resulted in focal centrilobular congestion and steatosis. Triacetyloleandomycin completely prevented the histological liver damage in all 8 animals. These results suggest that, in ethanol-treated rats, CYP3A plays a major role in increasing APAP hepatotoxicity. JF - Annals of clinical and laboratory science AU - Kostrubsky, V E AU - Szakacs, J G AU - Jeffery, E H AU - Woods, S G AU - Bement, W J AU - Wrighton, S A AU - Sinclair, P R AU - Sinclair, J F AD - Veterans Administration Medical Center, White River Junction, VT 05009, USA. PY - 1997 SP - 57 EP - 62 VL - 27 IS - 1 SN - 0091-7370, 0091-7370 KW - Cytochrome P-450 Enzyme Inhibitors KW - 0 KW - Enzyme Inhibitors KW - Acetaminophen KW - 362O9ITL9D KW - Ethanol KW - 3K9958V90M KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Troleandomycin KW - C4DZ64560D KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP3A KW - Oxidoreductases, N-Demethylating KW - EC 1.5.- KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Enzyme Inhibitors -- pharmacology KW - Cytochrome P-450 Enzyme System -- metabolism KW - Histocytochemistry KW - Male KW - Liver -- cytology KW - Troleandomycin -- pharmacology KW - Liver -- injuries KW - Ethanol -- pharmacology KW - Liver -- metabolism KW - Oxidoreductases, N-Demethylating -- antagonists & inhibitors KW - Oxidoreductases, N-Demethylating -- metabolism KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78786029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+clinical+and+laboratory+science&rft.atitle=Protection+of+ethanol-mediated+acetaminophen+hepatotoxicity+by+triacetyloleandomycin%2C+a+specific+inhibitor+of+CYP3A.&rft.au=Kostrubsky%2C+V+E%3BSzakacs%2C+J+G%3BJeffery%2C+E+H%3BWoods%2C+S+G%3BBement%2C+W+J%3BWrighton%2C+S+A%3BSinclair%2C+P+R%3BSinclair%2C+J+F&rft.aulast=Kostrubsky&rft.aufirst=V&rft.date=1997-01-01&rft.volume=27&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Annals+of+clinical+and+laboratory+science&rft.issn=00917370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-26 N1 - Date created - 1997-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cigarette smoke increases gastric ulcer size in part by an angiotensin II-mediated mechanism in rats. AN - 78784004; 9009118 AB - To assess the mechanism of the effect of cigarette smoke on ulcer disease we employed a rat model in which cigarette smoke increases the size of acetic acid-induced gastric ulcer and decreases the hyperemia at the ulcer margin. We postulate that cigarette smoke increases angiotensin II (a vasoconstrictor) in ulcer tissue. Since direct measurement of angiotensin II in small tissue samples is problematic, we compared the messenger ribonucleic acid (mRNA) for its precursors (angiotensinogen and renin) in ulcer and normal gastric tissue. We also evaluated the effect of enalapril, which blocks the conversion of angiotensin I to angiotensin II on ulcer size. In the ulcer tissue, cigarette smoke produced a significant increase in mRNA for angiotensinogen but not for renin. Enalapril decreased the size of the gastric ulcer in rats exposed to cigarette smoke. The data support the possibility that in ulcer tissue cigarette smoke stimulates an angiotensin II-mediated mechanism, which may in part be responsible for the impairment of ulcer margin hyperemia and aggravation of ulcer size. JF - Digestive diseases and sciences AU - Seno, K AU - Zhu, J H AU - Barrett, J D AU - Eggena, P AU - Scremin, O U AU - Lam, K AU - Leung, J W AU - Leung, F W AD - Gastroenterology Laboratory, Sepulveda and West Los Angeles Veterans Administration Medical Center California, 91343, USA. Y1 - 1997/01// PY - 1997 DA - January 1997 SP - 74 EP - 78 VL - 42 IS - 1 SN - 0163-2116, 0163-2116 KW - Angiotensin-Converting Enzyme Inhibitors KW - 0 KW - Platelet-Derived Growth Factor KW - RNA, Messenger KW - Somatomedins KW - Transforming Growth Factor beta KW - Angiotensin II KW - 11128-99-7 KW - Enalapril KW - 69PN84IO1A KW - Renin KW - EC 3.4.23.15 KW - Abridged Index Medicus KW - Index Medicus KW - Transforming Growth Factor beta -- analysis KW - Somatomedins -- analysis KW - Rats KW - Renin -- analysis KW - Immunoblotting KW - Animals KW - Rats, Sprague-Dawley KW - RNA, Messenger -- analysis KW - Platelet-Derived Growth Factor -- analysis KW - Enalapril -- pharmacology KW - Male KW - Angiotensin-Converting Enzyme Inhibitors -- pharmacology KW - Angiotensin II -- metabolism KW - Angiotensin II -- physiology KW - Smoking -- adverse effects KW - Stomach Ulcer -- metabolism KW - Stomach Ulcer -- pathology KW - Stomach Ulcer -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78784004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Cigarette+smoke+increases+gastric+ulcer+size+in+part+by+an+angiotensin+II-mediated+mechanism+in+rats.&rft.au=Seno%2C+K%3BZhu%2C+J+H%3BBarrett%2C+J+D%3BEggena%2C+P%3BScremin%2C+O+U%3BLam%2C+K%3BLeung%2C+J+W%3BLeung%2C+F+W&rft.aulast=Seno&rft.aufirst=K&rft.date=1997-01-01&rft.volume=42&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-02-19 N1 - Date created - 1997-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of oxidants in microbial pathophysiology. AN - 78766991; 8993856 AB - Reactive oxidant species (superoxide, hydrogen peroxide, hydroxyl radical, hypohalous acid, and nitric oxide) are involved in many of the complex interactions between the invading microorganism and its host. Regardless of the source of these compounds or whether they are produced under normal conditions or those of oxidative stress, these oxidants exhibit a broad range of toxic effects to biomolecules that are essential for cell survival. Production of these oxidants by microorganisms enables them to have a survival advantage in their environment. Host oxidant production, especially by phagocytes, is a counteractive mechanism aimed at microbial killing. However, this mechanism may be contribute to a deleterious consequence of oxidant exposure, i.e., inflammatory tissue injury. Both the host and the microorganism have evolved complex adaptive mechanisms to deflect oxidant-mediated damage, including enzymatic and nonenzymatic oxidant-scavenging systems. This review discusses the formation of reactive oxidant species in vivo and how they mediate many of the processes involved in the complex interplay between microbial invasion and host defense. JF - Clinical microbiology reviews AU - Miller, R A AU - Britigan, B E AD - Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, Iowa, USA. Y1 - 1997/01// PY - 1997 DA - January 1997 SP - 1 EP - 18 VL - 10 IS - 1 SN - 0893-8512, 0893-8512 KW - Oxidants KW - 0 KW - Superoxides KW - 11062-77-4 KW - Nitric Oxide KW - 31C4KY9ESH KW - Hydrogen Peroxide KW - BBX060AN9V KW - Iron KW - E1UOL152H7 KW - Peroxidase KW - EC 1.11.1.7 KW - Index Medicus KW - Bacteria -- metabolism KW - Animals KW - Fungi -- metabolism KW - Oxidants -- pharmacology KW - Viruses -- metabolism KW - Parasites -- metabolism KW - Humans KW - Peroxidase -- metabolism KW - Immunity, Innate KW - Phagocytosis KW - Iron -- metabolism KW - Nitric Oxide -- toxicity KW - Hydrogen Peroxide -- metabolism KW - Mycoses -- metabolism KW - Nitric Oxide -- metabolism KW - Nitric Oxide -- physiology KW - Parasitic Diseases -- metabolism KW - Hydrogen Peroxide -- toxicity KW - Bacterial Infections -- metabolism KW - Superoxides -- metabolism KW - Bacterial Infections -- prevention & control KW - Mycoses -- prevention & control KW - Parasitic Diseases -- prevention & control KW - Virus Diseases -- prevention & control KW - Virus Diseases -- metabolism KW - Superoxides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78766991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+microbiology+reviews&rft.atitle=Role+of+oxidants+in+microbial+pathophysiology.&rft.au=Miller%2C+R+A%3BBritigan%2C+B+E&rft.aulast=Miller&rft.aufirst=R&rft.date=1997-01-01&rft.volume=10&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Clinical+microbiology+reviews&rft.issn=08938512&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-04-08 N1 - Date created - 1997-04-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Biochem Biophys. 1992 Aug 1;296(2):547-55 [1321589] Eur J Clin Invest. 1992 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Each adolescent & a collateral informant (usually a parent) were interviewed while in treatment using the Customary Drinking & Drug Use Record & the Conduct Disorder Questionnaire. Analysis indicators that non-Hispanic Caucasian adolescents were three times as likely to be diagnosed with conduct disorder prior to onset of substance involvement than their Hispanic peers. Hispanic adolescents were more likely to have been involved in a gang. The conduct disorder behaviors of Hispanic adolescents were more highly correlated with their substance involvement compared to non-Hispanic Caucasian adolescents: conduct disorder behaviors were predictive of drug involvement & dependence symptoms at the time of treatment entry for Hispanic teens, while they did not predict substance involvement for non-Hispanic Caucasian teens. Results suggest (1) ethnic differences in the developmental course of conduct problems & substance involvement among adolescents in treatment for substance abuse & (2) different etiologic pathways to alcohol & drug abuse across ethnic groups. 4 Tables, 38 References. Adapted from the source document. JF - Journal of Child & Adolescent Substance Abuse AU - Stewart, David G AU - Brown, Sandra A AU - Myers, Mark G AD - c/o Brown -- Psychology Service Veterans Administration Medical Center, San Diego CA 92161 Y1 - 1997///0, PY - 1997 DA - 0, 1997 SP - 1 EP - 22 VL - 6 IS - 4 SN - 1067-828X, 1067-828X KW - Whites KW - Alcohol Abuse KW - Substance Abuse KW - Hispanic Americans KW - Racial Differences KW - Deviant Behavior KW - Treatment KW - Adolescents KW - Drug Abuse KW - article KW - 6129: social welfare KW - 6142: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61519833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+%26+Adolescent+Substance+Abuse&rft.atitle=Antisocial+Behavior+and+Psychoactive+Substance+Involvement+among+Hispanic+and+Non-Hispanic+Caucasian+Adolescents+in+Substance+Abuse+Treatment&rft.au=Stewart%2C+David+G%3BBrown%2C+Sandra+A%3BMyers%2C+Mark+G&rft.aulast=Stewart&rft.aufirst=David&rft.date=1997-01-01&rft.volume=6&rft.issue=4&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+%26+Adolescent+Substance+Abuse&rft.issn=1067828X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Treatment; Deviant Behavior; Hispanic Americans; Adolescents; Whites; Racial Differences; Substance Abuse; Drug Abuse; Alcohol Abuse ER - TY - JOUR T1 - Visualization of the Cerebral Circulation Using Three-dimensional Transcranial Power Doppler Ultrasound Imaging AN - 1780517286; PQ0002825738 AB - The purpose of this study was to evaluate the anatomy of the cerebral circulation, particularly the circle of Willis, using three-dimensional ultrasound (3DUS) imaging. Image data were obtained through the right transtemporal window from 8 young, healthy volunteers by acquiring gray-scale and color Doppler spectral (CDI) and energy (CDE) images using two-dimensional ultrasound equipment with a 2-MHz probe. Images and transducer position coordinates were fed into a graphics workstation, reprojected, analyzed to extract the blood flow signal, volume rendered, and displayed interactively. The architecture of the cerebral circulation was evaluated from multiple orientations using stereo viewing glasses and rotation to enhance the understanding of vessel position. The primary vessels of the cerebral circulation including the circle of Willis and bilateral views of the branching arteries (middle, anterior, and posterior cerebral arteries and internal carotid artery) could be imaged readily with 3DUS through one transtemporal window. Acquisition time was typically less than 30 seconds. Volume-rendering methods greatly assisted in showing the overall spatial relationships and continuity of cranial vessels. Secondary branches of the cerebral arteries were seen in 2 patients. Color data from two-dimensional ultrasound imaging that otherwise might be identified as artifact was found to represent continuous small vessels on three-dimensional viewing. 3DUS facilitates imaging of cranial vascular anatomy by clarifying overall spatial relationships and enhancing comprehension, compared to two-dimensional ultrasound methods. The method is rapid and the circle of Willis can be visualized from one side of the head. JF - Journal of Neuroimaging AU - Lyden, Patrick D AU - Nelson, Thomas R AD - Department of Neurosciences University of California, San Diego La Jolla, CA Research and Neurology Services Veterans Administration Medical Center-San Diego San Diego, CA. Y1 - 1997/01// PY - 1997 DA - January 1997 SP - 35 EP - 39 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 7 IS - 1 SN - 1051-2284, 1051-2284 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Neuroimaging KW - Data processing KW - Head KW - Doppler effect KW - Probes KW - Color KW - Skull KW - Energy KW - Computed tomography KW - Carotid artery KW - Ultrasound KW - Cerebral blood flow KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780517286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroimaging&rft.atitle=Visualization+of+the+Cerebral+Circulation+Using+Three-dimensional+Transcranial+Power+Doppler+Ultrasound+Imaging&rft.au=Lyden%2C+Patrick+D%3BNelson%2C+Thomas+R&rft.aulast=Lyden&rft.aufirst=Patrick&rft.date=1997-01-01&rft.volume=7&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroimaging&rft.issn=10512284&rft_id=info:doi/10.1111%2Fjon19977135 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Data processing; Head; Skull; Doppler effect; Energy; Computed tomography; Probes; Carotid artery; Ultrasound; Cerebral blood flow; Color DO - http://dx.doi.org/10.1111/jon19977135 ER - TY - JOUR T1 - Hospice Organizations' Role in Health Care Improvement AN - 1761704561; 199701392 AB - It is proposed that hospice organizations shift their thinking about their role in the health care system. Hospices should (1) view their work as processes that can be impacted by many entities in the system; (2) measure the outcomes of this work against the needs of patients, families, & health care providers; & (3) consider implications for hospice organizations. Using this new understanding, hospice organizations can both broaden their impact on care for larger numbers of dying patients & position themselves to move forward in that system as the financial base & structure of health care change. 2 Figures, 2 References. Adapted from the source document. JF - The Hospice Journal AU - Goodlin, Sarah J AD - Geriatrics & Extended Care White River Junction Veterans Administration Medical Center, VT 05009 Y1 - 1997///0, PY - 1997 DA - 0, 1997 SP - 71 EP - 80 VL - 12 IS - 2 SN - 0742-969X, 0742-969X KW - health care improvement, hospice organizations' role change proposal KW - Health Care KW - Health Services KW - Hospices KW - Quality of Health Care KW - Delivery Systems KW - article KW - 6140: illness & health care KW - 6124: health care promotion/education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761704561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Hospice+Journal&rft.atitle=Hospice+Organizations%27+Role+in+Health+Care+Improvement&rft.au=Goodlin%2C+Sarah+J&rft.aulast=Goodlin&rft.aufirst=Sarah&rft.date=1997-01-01&rft.volume=12&rft.issue=2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=The+Hospice+Journal&rft.issn=0742969X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Hospices; Health Services; Health Care; Delivery Systems; Quality of Health Care ER - TY - JOUR T1 - The Perceived Availability, Quality, and Cost of Long-Term Care Services in America AN - 1761694911; 199802754 AB - Investigates the patterns & predictors of home-based, community-based, & institutional long-term care services for older adults residing in the US, drawing on 1994 semistructured survey data from a stratified random sample of 153 policymakers & agency representatives. Descriptive analyses revealed significant differences in perceived access, use, quality, & costs of care by service type & agency affiliation. Results present an interesting dilemma for policymakers -- many of the most widely available & highest-quality services were too costly. Implications for public policy & suggestions for further research are highlighted. 4 Tables, 1 Figure, 26 References. Adapted from the source document. JF - Journal of Aging & Social Policy AU - Rabiner, Donna J AU - Arcury, Thomas A AU - Howard, Hilda A AU - Copeland, Kristen A AD - National Center for Health Promotion Veterans Administration Medical Center, 508 Fulton St Durham NC 27705 Y1 - 1997///0, PY - 1997 DA - 0, 1997 SP - 43 EP - 65 VL - 9 IS - 3 SN - 0895-9420, 0895-9420 KW - long-term care KW - Health Services KW - Quality of Health Care KW - Elderly KW - United States of America KW - Community Services KW - Health Policy KW - Health Care Costs KW - article KW - 7211: health policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761694911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aging+%26+Social+Policy&rft.atitle=The+Perceived+Availability%2C+Quality%2C+and+Cost+of+Long-Term+Care+Services+in+America&rft.au=Rabiner%2C+Donna+J%3BArcury%2C+Thomas+A%3BHoward%2C+Hilda+A%3BCopeland%2C+Kristen+A&rft.aulast=Rabiner&rft.aufirst=Donna&rft.date=1997-01-01&rft.volume=9&rft.issue=3&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aging+%26+Social+Policy&rft.issn=08959420&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - United States of America; Health Care Costs; Quality of Health Care; Community Services; Elderly; Health Policy; Health Services ER - TY - JOUR T1 - Use of a Screening Instrument in Women's Health Care: Detecting Relationships among Victimization History, Psychological Distress, and Medical Complaints AN - 1761692779; 199802791 AB - Examines the utility of a brief screening measure in detecting psychological factors in female patients at a primary care facility, drawing on sexual assault & lifestyle histories from 108 women, ages 22-91, screened at a women's health clinic, 1994/95. A history of trauma was reported by 69% & 49% reported having been sexually harassed. Women who were treated for gynecological problems were more likely to be victims of sexual assault & to report a history of childhood sexual abuse. Further, women seeking specialized health care reported increased rates of stress. Relationships among victimization histories substance use, & eating disturbances were also found. These results suggest the importance of assessing psychological disturbances & trauma histories as part of a comprehensive medical evaluation. 2 Tables, 49 References. Adapted from the source document. JF - Women and Health AU - Read, Jennifer P AU - Stern, Amy Leventhal AU - Wolfe, Jessica AU - Ouimette, Paige Crosby AD - c/o Stern -- Dept Veterans Affairs Medical Center National Center Post-Traumatic Stress Disorder, 150 South Huntington Ave Boston MA 02130 Y1 - 1997///0, PY - 1997 DA - 0, 1997 SP - 1 EP - 17 VL - 25 IS - 3 SN - 0363-0242, 0363-0242 KW - Diagnosis KW - Sexual Assault KW - Health Problems KW - Psychological Distress KW - Womens Health Care KW - Victimization KW - article KW - 6148: problems of minority groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761692779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women+and+Health&rft.atitle=Use+of+a+Screening+Instrument+in+Women%27s+Health+Care%3A+Detecting+Relationships+among+Victimization+History%2C+Psychological+Distress%2C+and+Medical+Complaints&rft.au=Read%2C+Jennifer+P%3BStern%2C+Amy+Leventhal%3BWolfe%2C+Jessica%3BOuimette%2C+Paige+Crosby&rft.aulast=Read&rft.aufirst=Jennifer&rft.date=1997-01-01&rft.volume=25&rft.issue=3&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Women+and+Health&rft.issn=03630242&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Womens Health Care; Sexual Assault; Psychological Distress; Diagnosis; Victimization; Health Problems ER - TY - JOUR T1 - Quantitative detection of hepatitis C virus RNA in patients undergoing hemodialysis AN - 15937667; 271366 AB - To quantitatively detect hepatitis C virus (HCV)-RNA, 88 patients undergoing maintenance hemodialysis were evaluated. Anti-HCV was determined by enzyme linked immunosorbent assay (ELISA) which was confirmed by four antigen strip immunoblot assay. HCV-RNA was quantified directly in the human sera with a branched DNA (bDNA) signal amplification assay. HCV-RNA by bDNA assay was proven to be a sensitive, specific, and simple test that can be used in association with antibody assays and a PCR based assay to study the prevalence and management of HCV infection in the dialysis setting. JF - ASAIO Journal AU - De Medina, Maria AU - LaRue, Silvia AU - Hill, Mary AU - O'Sullivan, Howard AU - Pennell, JPhillip AU - Leclercq, B AU - Li, Xiuming AU - Jeffers, Lennox AU - Parker, Talley AU - Reddy, KRajender AU - Schiff, Eugene R AU - Perez, Guido O AD - Veterans Administration Medical Cent, Miami, FL, USA Y1 - 1997 PY - 1997 DA - 1997 SP - 19 EP - 22 PB - LIPPINCOTT-RAVEN PUBL, HAGERSTOWN, MD, (USA) VL - 43 IS - 1 SN - 1058-2916, 1058-2916 KW - Antigen strip immunoblot assay KW - Antigen-antibody reactions KW - Bioassay KW - Enzyme linked immunosorbent assay (ELISA) KW - Hemodialysis KW - Living systems studies KW - Patient monitoring KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Blood KW - Dialysis KW - RNA KW - Immunology KW - W4 461.2:BIOLOGICAL MATERIALS KW - W4 462.2:HOSPITALS, EQUIPMENT AND SUPPLIES KW - W4 461.6:MEDICINE KW - W4 461.9:BIOLOGY KW - W4 461.1:BIOMEDICAL ENGINEERING KW - W4 461.9.1:IMMUNOLOGY KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15937667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ASAIO+Journal&rft.atitle=Quantitative+detection+of+hepatitis+C+virus+RNA+in+patients+undergoing+hemodialysis&rft.au=De+Medina%2C+Maria%3BLaRue%2C+Silvia%3BHill%2C+Mary%3BO%27Sullivan%2C+Howard%3BPennell%2C+JPhillip%3BLeclercq%2C+B%3BLi%2C+Xiuming%3BJeffers%2C+Lennox%3BParker%2C+Talley%3BReddy%2C+KRajender%3BSchiff%2C+Eugene+R%3BPerez%2C+Guido+O&rft.aulast=De+Medina&rft.aufirst=Maria&rft.date=1997-01-01&rft.volume=43&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=ASAIO+Journal&rft.issn=10582916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Blood; Dialysis; RNA; Immunology ER - TY - JOUR T1 - Radiation therapy in early carcinoma of the glottic larynx T1N0M0. AN - 85278676; pmid-8985045 AB - PURPOSE: The Purpose of this report is to present the local control rate and survival of patients treated by radiation therapy for T1N0M0 squamous cell carcinoma of the glottic larynx. METHODS AND MATERIALS: A total of 41 patients with squamous cell carcinoma of the glottis were treated at the Veterans Administration Medical Center Minneapolis, MN, between 1976 and 1990. Of the 41 patients, 40 are available for retrospective analysis with a minimum of a 2-year follow-up and a median follow-up of 5.8 years. Treatment was given to all the patients by a 4 MeV linear accelerator. The vast majority of the patients were treated with bilateral laryngeal opposed wedged 6 x 6 cm fields with a dose of 1.75 Gy per fraction to a total of 70 Gy in 40 fractions over 56 elapsed treatment days. RESULTS: The data indicated local control and survival of 92.3 % at 2 years and 91.8 % at 3 years, post irradiation, with ultimate disease-free survival after surgical salvage of 97.4 % and 97.2 % at 2 years and 3 years, respectively. These local control and survival rates are comparable to those published in the literature when a higher fractional dose was given. No patients developed notable complications with our technique. CONCLUSIONS: A dose of 1.75 Gy to 1.8 Gy per fraction to a total of 70 Gy in 56 elapsed treatment days is well tolerated and yields ultimate disease free-survival of 97.2% at 3 years. This time-dose fractionation could be used safely for treating patients who demonstrate low tolerance to irradiation with a risk of laryngitis, laryngeal edema, or difficulty of swallowing, with a higher fractional dose. JF - International Journal of Radiation Oncology, Biology, Physics AU - Medini, E AU - Medini, A AU - Gapany, M AU - Levitt, S H AD - Department of Radiation Oncology and Otolaryngology Veterans Administration Medical Center and University of Minnesota, Minneapolis 55417, USA. PY - 1996 SP - 1211 EP - 1213 VL - 36 IS - 5 SN - 0360-3016, 0360-3016 KW - Aged, 80 and over KW - Human KW - Radiotherapy Dosage KW - Adult KW - Aged KW - Middle Age KW - Laryngeal Neoplasms KW - Carcinoma, Squamous Cell KW - Male KW - Glottis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85278676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics&rft.atitle=Radiation+therapy+in+early+carcinoma+of+the+glottic+larynx+T1N0M0.&rft.au=Medini%2C+E%3BMedini%2C+A%3BGapany%2C+M%3BLevitt%2C+S+H&rft.aulast=Medini&rft.aufirst=E&rft.date=1996-12-01&rft.volume=36&rft.issue=5&rft.spage=1211&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics&rft.issn=03603016&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Inhibitory gating of an evoked response to repeated auditory stimuli in schizophrenic and normal subjects. Human recordings, computer simulation, and an animal model. AN - 85259555; pmid-8956677 AB - BACKGROUND: Altered sensory response is a prominent feature of schizophrenia. Inhibitory gatting mechanisms, shown by diminished P50 evoked responses to repeated auditory stimuli, seem to be deficient in schizophrenic persons. These inhibitory mechanisms usually are studied by averaging the electroencephalographic responses to many presentations of pairs of stimuli. Although averaging increases signal-to-noise ratio, it may obscure trial-to-trial differences. We compared differences between schizophrenic and normal persons in single trials and averages of P50 response. METHODS: Recordings from 10 schizophrenic patients and 10 normal subjects were analyzed using conventional averaging and single-trial measurements. A computer simulation of both methods examined their ability to extract evoked responses from background activity. Related single-neuron activity in the hippocampus in an animal model also was studied, because neuronal action potentials can be reliably identified in single trials. RESULTS: Averaged evoked potentials showed significant suppression of the P50 response to the second stimulus of the pair in normal patients, but not in schizophrenic patients. Single-trial analysis did not detect a response above background activity. Computer simulations gave similar results, suggesting that failure to detect suppression in single trials comes from inadequate differentiation of signal from noise. Recordings in animals confirmed almost complete suppression of the response of hippocampal pyramidal neurons to the second stimulus. CONCLUSIONS: The normal inhibition of response to repeated auditory stimuli seems to be compromised in schizophrenia. This loss of inhibitory gating could reflect a physiological deficit of hippocampal interneurons that is consonant with other evidence for interneuron pathologic defects in schizophrenia. JF - Archives of General Psychiatry AU - Freedman, R AU - Adler, L E AU - Myles-Worsley, M AU - Nagamoto, H T AU - Miller, C AU - Kisley, M AU - McRae, K AU - Cawthra, E AU - Waldo, M AD - Department of Psychiatry, Denver Veterans Administration Medical Center, Colo, USA. PY - 1996 SP - 1114 EP - 1121 VL - 53 IS - 12 SN - 0003-990X, 0003-990X KW - Support, U.S. Gov't, P.H.S. KW - Computer Simulation KW - Hippocampus KW - Human KW - Animal KW - Action Potentials KW - Schizophrenia KW - Rats KW - Rats, Sprague-Dawley KW - Conditioning (Psychology) KW - Adult KW - Middle Age KW - Support, U.S. Gov't, Non-P.H.S. KW - Acoustic Stimulation KW - Male KW - Female KW - Reaction Time KW - Electroencephalography KW - Evoked Potentials, Auditory KW - Neural Inhibition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85259555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+General+Psychiatry&rft.atitle=Inhibitory+gating+of+an+evoked+response+to+repeated+auditory+stimuli+in+schizophrenic+and+normal+subjects.+Human+recordings%2C+computer+simulation%2C+and+an+animal+model.&rft.au=Freedman%2C+R%3BAdler%2C+L+E%3BMyles-Worsley%2C+M%3BNagamoto%2C+H+T%3BMiller%2C+C%3BKisley%2C+M%3BMcRae%2C+K%3BCawthra%2C+E%3BWaldo%2C+M&rft.aulast=Freedman&rft.aufirst=R&rft.date=1996-12-01&rft.volume=53&rft.issue=12&rft.spage=1114&rft.isbn=&rft.btitle=&rft.title=Archives+of+General+Psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Five primary synchronous neoplasms of the gastrointestinal tract. AN - 85206196; pmid-8957731 AB - Multiple primary malignant neoplasms in a single patient have been well documented in the literature over the past hundred years. The lesions can be limited to a single organ or involve multiple organ systems. It is relatively common for patients with colorectal carcinoma or carcinoid tumors to have more than one primary neoplasm. Colonic lesions can be synchronous or metachronous in presentation and colonic or extracolonic in location. We present a patient with five primary synchronous neoplasms of the gastrointestinal tract, involving the stomach, small bowel, and colon. The patient had no evidence of metastatic disease and underwent resection of all the lesions. This case illustrates the need for a thorough search for additional neoplasms in the treatment of patients with cancer. JF - Journal of Clinical Gastroenterology AU - Mitchell, M E AU - Johnson, J A AU - Wilton, P B AD - Department of Surgery, Veterans Administration Medical Center, Jackson, Mississippi, USA. PY - 1996 SP - 284 EP - 288 VL - 23 IS - 4 SN - 0192-0790, 0192-0790 KW - Ileal Neoplasms KW - Human KW - Stomach Neoplasms KW - Aged KW - Carcinoid Tumor KW - Case Report KW - Adenocarcinoma KW - Colonic Neoplasms KW - Carcinoma, Signet Ring Cell KW - Male KW - Neoplasms, Multiple Primary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85206196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Five+primary+synchronous+neoplasms+of+the+gastrointestinal+tract.&rft.au=Mitchell%2C+M+E%3BJohnson%2C+J+A%3BWilton%2C+P+B&rft.aulast=Mitchell&rft.aufirst=M&rft.date=1996-12-01&rft.volume=23&rft.issue=4&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Asymptomatic carotid stenosis and stroke during neck surgery. AN - 85201760; pmid-8969764 JF - Otolaryngology--Head and Neck Surgery AU - Sprung, J AU - Jones, F D AU - Rosen, J S AU - Thomas, P AU - Bourke, D L AD - Department of Anesthesiology and Surgical Services, Veterans Administration Medical Center, Baltimore, Maryland, USA. PY - 1996 SP - 568 EP - 572 VL - 115 IS - 6 SN - 0194-5998, 0194-5998 KW - Carotid Stenosis KW - Endarterectomy KW - Fatal Outcome KW - Carotid Artery, Internal KW - Human KW - Aged KW - Brain Ischemia KW - Case Report KW - Brain Edema KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85201760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--Head+and+Neck+Surgery&rft.atitle=Asymptomatic+carotid+stenosis+and+stroke+during+neck+surgery.&rft.au=Sprung%2C+J%3BJones%2C+F+D%3BRosen%2C+J+S%3BThomas%2C+P%3BBourke%2C+D+L&rft.aulast=Sprung&rft.aufirst=J&rft.date=1996-12-01&rft.volume=115&rft.issue=6&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Structure-function relationships in the heparin-binding C-terminal region of insulin-like growth factor binding protein-3. AN - 78629078; 8971549 AB - IGFBP-3 contains a carboxyterminal basic region which, when present as an isolated 18 amino acid peptide (P3), binds heparin, associates with cultured endothelial cells and stimulates glucose uptake. The P3 molecule has now been modified relative to charge, amino acid sequence and size to determine structure-function relationships relative to four properties of P3: affinity for heparin; inhibition of IGFBP-3 binding; stimulation of glucose uptake; and displacement of bFGF from the extracellular matrix of endothelial cells. Results indicate: (1) the presence or absence of heparin binding was concordant with the presence/absence of the other three properties; (2) the number of basic amino acids was an important, if not limiting, factor for each property; (3) the order of potency of the basic amino acids was arginine = lysine > > histidine; (4) the unrelated, basic protein, protamine, mimics all properties of P3; and (5) the putative consensus heparin-binding sequence of P3 was not essential for any of the P3 activities. JF - Growth regulation AU - Booth, B A AU - Boes, M AU - Dake, B L AU - Linhardt, R J AU - Caldwell, E E AU - Weiler, J M AU - Bar, R S AD - Veterans Administration Medical Center, Department of Internal Medicine, Iowa City, Iowa 52246, USA. Y1 - 1996/12// PY - 1996 DA - December 1996 SP - 206 EP - 213 VL - 6 IS - 4 SN - 0956-523X, 0956-523X KW - Anticoagulants KW - 0 KW - Antimetabolites KW - Insulin-Like Growth Factor Binding Protein 3 KW - Recombinant Proteins KW - Fibroblast Growth Factors KW - 62031-54-3 KW - Heparin KW - 9005-49-6 KW - Deoxyglucose KW - 9G2MP84A8W KW - Index Medicus KW - Animals KW - Endothelium, Vascular -- metabolism KW - Extracellular Matrix -- metabolism KW - Recombinant Proteins -- pharmacology KW - Sequence Homology, Nucleic Acid KW - Humans KW - Amino Acid Sequence KW - Fibroblast Growth Factors -- metabolism KW - Structure-Activity Relationship KW - Cattle KW - Antimetabolites -- metabolism KW - Cells, Cultured KW - Molecular Sequence Data KW - Deoxyglucose -- metabolism KW - Anticoagulants -- metabolism KW - Heparin -- metabolism KW - Insulin-Like Growth Factor Binding Protein 3 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78629078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Growth+regulation&rft.atitle=Structure-function+relationships+in+the+heparin-binding+C-terminal+region+of+insulin-like+growth+factor+binding+protein-3.&rft.au=Booth%2C+B+A%3BBoes%2C+M%3BDake%2C+B+L%3BLinhardt%2C+R+J%3BCaldwell%2C+E+E%3BWeiler%2C+J+M%3BBar%2C+R+S&rft.aulast=Booth&rft.aufirst=B&rft.date=1996-12-01&rft.volume=6&rft.issue=4&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Growth+regulation&rft.issn=0956523X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-19 N1 - Date created - 1997-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diminished platelet binding in vitro by Staphylococcus aureus is associated with reduced virulence in a rabbit model of infective endocarditis. AN - 78576375; 8945526 AB - The direct binding of platelets by bacteria is a postulated central mechanism in the pathogenesis of endocarditis. To address the role of binding more definitively, we employed Tn551 insertional mutagenesis of Staphylococcus aureus parental strain ISP479 to generate an isogenic variant (strain PS12) that bound platelets minimally. As compared with the binding of ISP479, the binding of PS12 to platelet monolayers was reduced by 67.2%. Similarly, the binding of PS12 to platelets in suspension was reduced by 71.3%, as measured by flow cytometry. The low-binding phenotype was transducible into both ISP479 and S. aureus Newman. Southern blotting indicated that a single copy of Tn551 was inserted within the chromosomes of PS12 and the transductants. When tested in a rabbit model, animals inoculated with PS12 were significantly less likely to develop endocarditis and had lower densities of organisms (CFU per gram) within vegetations and a decreased incidence of renal abscess formation, as compared with animals inoculated with the parental strain. The diminished virulence of PS12 was not attributable to a reduction in the initial attachment of organisms to the damaged endocardium, since 30 min after inoculation, PS12-infected animals had microbial densities on the valve surface comparable to those seen with the parental strain. These results indicate that the direct binding of Staphylococcus aureus to platelets is a major determinant of virulence in the pathogenesis of endocarditis. Staphylococcus-platelet binding appears to be critical for pathogenetic events occurring after the initial colonization of the valve surface, such as vegetation formation and septic embolization. JF - Infection and immunity AU - Sullam, P M AU - Bayer, A S AU - Foss, W M AU - Cheung, A L AD - Department of Medicine, Veterans Affairs Medical Center and University of California, San Francisco 94121, USA. sullam@sanfrancisco.va.gov Y1 - 1996/12// PY - 1996 DA - December 1996 SP - 4915 EP - 4921 VL - 64 IS - 12 SN - 0019-9567, 0019-9567 KW - Index Medicus KW - Virulence KW - Animals KW - Bacterial Adhesion KW - Rabbits KW - Endocarditis, Bacterial -- microbiology KW - Blood Platelets -- microbiology KW - Endocarditis, Bacterial -- blood KW - Staphylococcus aureus -- pathogenicity KW - Staphylococcal Infections -- microbiology KW - Staphylococcal Infections -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78576375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Diminished+platelet+binding+in+vitro+by+Staphylococcus+aureus+is+associated+with+reduced+virulence+in+a+rabbit+model+of+infective+endocarditis.&rft.au=Sullam%2C+P+M%3BBayer%2C+A+S%3BFoss%2C+W+M%3BCheung%2C+A+L&rft.aulast=Sullam&rft.aufirst=P&rft.date=1996-12-01&rft.volume=64&rft.issue=12&rft.spage=4915&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-01-08 N1 - Date created - 1997-01-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Exp Pathol. 1972 Feb;53(1):44-9 [5014243] J Bacteriol. 1996 Aug;178(15):4563-70 [8755885] Proc Natl Acad Sci U S A. 1979 Jan;76(1):400-4 [284355] J Bacteriol. 1983 Apr;154(1):479-87 [6300037] J Infect Dis. 1985 Jan;151(1):157-65 [3965588] Vet Pathol. 1986 Nov;23(6):780-2 [3811145] Infect Immun. 1987 Aug;55(8):1743-50 [3112008] Infect Immun. 1989 Aug;57(8):2306-12 [2545622] Infect Immun. 1990 Nov;58(11):3802-6 [2228249] Methods Enzymol. 1991;204:587-636 [1658572] Infect Immun. 1992 Mar;60(3):1202-9 [1541535] J Infect Dis. 1992 Jul;166(1):65-73 [1318911] Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6462-6 [1321441] J Infect Dis. 1993 Feb;167(2):312-22 [8421166] Infect Immun. 1993 Apr;61(4):1593-5 [8454370] J Infect Dis. 1993 Oct;168(4):910-4 [8376837] Infect Immun. 1994 May;62(5):1719-25 [8168933] Antimicrob Agents Chemother. 1994 Apr;38(4):729-32 [8031037] Coron Artery Dis. 1994 Apr;5(4):339-45 [7519107] J Clin Invest. 1994 Nov;94(5):1815-22 [7962526] Antimicrob Agents Chemother. 1994 Jul;38(7):1460-5 [7979272] Infect Immun. 1995 Feb;63(2):663-71 [7822036] Infect Immun. 1995 Sep;63(9):3628-33 [7642300] Infect Immun. 1995 Sep;63(9):3634-41 [7642301] J Bacteriol. 1996 Jan;178(2):418-23 [8550461] J Pathol. 1975 Feb;115(2):81-9 [1151519] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Two-Year Outcome of Social Skills Training and Group Psychotherapy for Outpatients with Schizophrenia AN - 61502469; 9714549 AB - To study the effects of social skills training & supportive group therapy on the social adjustment & risk of psychotic relapse of schizophrenic subjects, 80 male patients at a Veterans Administration hospital in Los Angeles, CA, were pharmaceutically stabilized & randomly assigned to receive either social skills training or supportive group therapy twice a week for 6 months & then weekly for 18 months. Results indicate that this intervention resulted in improved personal well-being & scores on a social adjustment scale. The greatest social outcome improvements occurred when social skills training was combined with active drug supplementation at the time psychotic symptoms were first observed. 3 Tables, 1 Appendix, 25 References. M. Greenberg JF - The American Journal of Psychiatry AU - Marder, Stephen R AU - Wirshing, William C AU - Mintz, Jim AU - McKenzie, Joanne AU - Johnston, Kathleen AU - Eckman, Thad A AU - Lebell, Malca AU - Zimmerman, Karin AU - Liberman, Robert P AD - Psychiatry Service West Los Angeles Veterans Administration Medical Center, 11301 Wilshire Blvd CA 90073 marder@ucla.edu Y1 - 1996/12// PY - 1996 DA - December 1996 SP - 1585 EP - 1592 VL - 153 IS - 12 SN - 0002-953X, 0002-953X KW - social adjustment/psychotic relapse risk, male schizophrenic patients KW - social skills training, group therapy, pharmaceutical treatment KW - scale data KW - hospital, Los Angeles, California KW - Schizophrenia KW - Outpatients KW - Treatment Outcomes KW - Mental Patients KW - Medications KW - Social Competence KW - Group Therapy KW - Adjustment KW - Treatment Methods KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61502469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Two-Year+Outcome+of+Social+Skills+Training+and+Group+Psychotherapy+for+Outpatients+with+Schizophrenia&rft.au=Marder%2C+Stephen+R%3BWirshing%2C+William+C%3BMintz%2C+Jim%3BMcKenzie%2C+Joanne%3BJohnston%2C+Kathleen%3BEckman%2C+Thad+A%3BLebell%2C+Malca%3BZimmerman%2C+Karin%3BLiberman%2C+Robert+P&rft.aulast=Marder&rft.aufirst=Stephen&rft.date=1996-12-01&rft.volume=153&rft.issue=12&rft.spage=1585&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Outpatients; Schizophrenia; Social Competence; Group Therapy; Adjustment; Treatment Methods; Treatment Outcomes; Medications; Mental Patients ER - TY - JOUR T1 - In vitro assessment of neurotrophic activity from the striatum of aging rats. AN - 78577651; 8945752 AB - Neurotrophic factors are produced in the striatum following trauma and have a demonstrable effect on in vitro bioassays and on in vivo graft survival. We have previously measured the in vitro effect of these factors following trauma to the striatum of young rats. However, the effect of age on this neurotrophic response has not been evaluated. In this study we report on the in vitro effects of extracts (obtained from gelfoam) removed from striatal cavities 7 days following trauma. Gelfoam extract from aged rats (18-24 months) had a reduced neurite-promoting response in dorsal root ganglia (DRG) and SH-SY5Y (a dopamine-producing neuroblastoma cell line) assays, compared to gelfoam from young rats (2-3 months). In contrast, extracts from both young and old rats showed significant neuroprotection of SH-SY5Y cells from the dopaminergic neurotoxins N-methy-4phenylpyridinium ion (MPP +) and 6-hydroxydopamine (6-OHDA). The results suggest that the striatum of aged individuals may have (1) a diminished capacity of neurite promotion and/ or (2) that neurite outgrowth and neuroprotection may be influenced by different factors or different levels of the same factors. The direct implication is that aged animals would be the most appropriate models to study experimental therapies for Parkinson's disease. JF - Neuroscience letters AU - Kaseloo, P A AU - Lis, A AU - Asada, H AU - Barone, T A AU - Plunkett, R J AD - Department of Neurosurgery, Buffalo Veterans Administration Medical Center, NY, USA. Y1 - 1996/11/08/ PY - 1996 DA - 1996 Nov 08 SP - 157 EP - 160 VL - 218 IS - 3 SN - 0304-3940, 0304-3940 KW - Cell Extracts KW - 0 KW - Dopamine Agents KW - Nerve Growth Factors KW - Sympatholytics KW - Oxidopamine KW - 8HW4YBZ748 KW - 1-Methyl-4-phenylpyridinium KW - R865A5OY8J KW - Index Medicus KW - Animals KW - Cell Extracts -- pharmacology KW - Cell Line -- drug effects KW - Chick Embryo KW - Dopamine Agents -- pharmacology KW - Disease Models, Animal KW - Cells, Cultured -- drug effects KW - Neurites -- physiology KW - Cell Line -- physiology KW - Neurons -- ultrastructure KW - Oxidopamine -- pharmacology KW - Sympatholytics -- pharmacology KW - Rats KW - Ganglia, Spinal -- cytology KW - Ciliary Body -- cytology KW - Rats, Sprague-Dawley KW - Neurites -- drug effects KW - Craniocerebral Trauma -- physiopathology KW - Neurons -- cytology KW - Neurons -- physiology KW - Nerve Regeneration -- physiology KW - Cells, Cultured -- physiology KW - Female KW - 1-Methyl-4-phenylpyridinium -- pharmacology KW - Aging -- physiology KW - Neostriatum -- physiology KW - Neostriatum -- cytology KW - Nerve Growth Factors -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78577651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=In+vitro+assessment+of+neurotrophic+activity+from+the+striatum+of+aging+rats.&rft.au=Kaseloo%2C+P+A%3BLis%2C+A%3BAsada%2C+H%3BBarone%2C+T+A%3BPlunkett%2C+R+J&rft.aulast=Kaseloo&rft.aufirst=P&rft.date=1996-11-08&rft.volume=218&rft.issue=3&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-04 N1 - Date created - 1997-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A negative regulatory region in the intracellular domain of the human interferon-alpha receptor. AN - 78514702; 8910507 AB - Interferon-alpha (IFN-alpha)-mediated intracellular signaling is initiated by ligand-induced receptor dimerization, tyrosine phosphorylation of the Tyk2 and Jak1 tyrosine kinases, and subsequent phosphorylation of the Stat1 and Stat2 proteins. The IFN-alpha receptor consists of at least two distinct subunits. One subunit, IFNAR1, has low affinity binding for interferon yet is required for signal transduction. We introduced mutations in the cytoplasmic domain of human IFNAR1 in order to identify residues involved in the mediation of biological responses. We took advantage of the species specificity of the interferon receptors by analyzing human IFN-alpha-induced major histocompatibility complex class I antigen expression in mouse L929 cells stably transfected with mutant human receptors. The membrane proximal 60-amino acids were insufficient to signal a biological response even though within these residues Tyk2 and Stat2 binding sites have been identified. IFN-alpha-induced receptor tyrosine phosphorylation was not critical for signaling because mutation of Tyr residues to Phe did not prevent the biological response to IFN-alpha. The deletion of a 16-amino acid region highly homologous between species created a receptor which signals an enhanced response. Tyrosine dephosphorylation is a component of this enhanced response as mutation of the Tyr residues within this region to Phe resulted in a receptor with increased sensitivity to IFN. The known signaling molecules that interact with IFNAR1 are positive regulators of IFN-alpha function. The presence of this domain in the COOH-terminal region suggests that the receptor may interact with signaling molecules that negatively regulate interferon responses. JF - The Journal of biological chemistry AU - Gibbs, V C AU - Takahashi, M AU - Aguet, M AU - Chuntharapai, A AD - Department of Surgery, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA. gibbs.verna@sanfrancisco.va.gov Y1 - 1996/11/08/ PY - 1996 DA - 1996 Nov 08 SP - 28710 EP - 28716 VL - 271 IS - 45 SN - 0021-9258, 0021-9258 KW - Receptors, Interferon KW - 0 KW - Receptor, Interferon alpha-beta KW - 156986-95-7 KW - Tyrosine KW - 42HK56048U KW - Phenylalanine KW - 47E5O17Y3R KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - Phenylalanine -- metabolism KW - Phosphorylation KW - Transfection KW - Humans KW - Fibroblasts -- chemistry KW - Mice KW - Tyrosine -- metabolism KW - Structure-Activity Relationship KW - Receptors, Interferon -- genetics KW - Receptors, Interferon -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78514702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=A+negative+regulatory+region+in+the+intracellular+domain+of+the+human+interferon-alpha+receptor.&rft.au=Gibbs%2C+V+C%3BTakahashi%2C+M%3BAguet%2C+M%3BChuntharapai%2C+A&rft.aulast=Gibbs&rft.aufirst=V&rft.date=1996-11-08&rft.volume=271&rft.issue=45&rft.spage=28710&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-30 N1 - Date created - 1996-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Microvascular access in the multiply operated neck: thoracodorsal transposition. AN - 85190270; pmid-8914917 JF - The Laryngoscope AU - Dolan, R AU - Gooey, J AU - Cho, Y J AU - Fuleihan, N AD - Veterans Administration Medical Center, Jamaica Plains, Boston, USA. PY - 1996 SP - 1436 EP - 1437 VL - 106 IS - 11 SN - 0023-852X, 0023-852X KW - Human KW - Aged KW - Cutaneous Fistula KW - Case Report KW - Surgical Flaps KW - Neck KW - Pharyngeal Diseases KW - Male KW - Fistula UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85190270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Microvascular+access+in+the+multiply+operated+neck%3A+thoracodorsal+transposition.&rft.au=Dolan%2C+R%3BGooey%2C+J%3BCho%2C+Y+J%3BFuleihan%2C+N&rft.aulast=Dolan&rft.aufirst=R&rft.date=1996-11-01&rft.volume=106&rft.issue=11&rft.spage=1436&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Differential effects of ethanol in adolescent and adult rats. AN - 78586921; 8947309 AB - Alcohol use in children and adolescents is widespread. However, very little is known about the effects of alcohol exposure during this period of postnatal development. The goal of the present study was to compare the relative sensitivity to the sedative effects of alcohol in periadolescent and adult rats. After treatment with either 4 or 5 g/kg ethanol, both 20- and 30-day-old rats regained their righting reflex significantly earlier than 60-day old rats. In 30-day-old rats, serum ethanol concentrations (SECs) were significantly greater at the time of the recovery of the righting reflex than 60-day-old rats. Developmental differences in the effects of ethanol on locomotor activity were also observed. In 60-day-old rats, 2.5 g/kg ethanol generally decreased locomotor activity. Ethanol did not significantly alter locomotor activity in 20- and 30-day-old rats. Finally there were significant developmental differences in the pharmacokinetics of ethanol with a significant delay in the time to peak SECs in 60-day-old rats relative to 20- and 30-day-old rats. These findings indicate that peri-adolescent rats are less sensitive to the sedative effects of ethanol as they recovered their righting reflex earlier and at significantly higher SECs than adult rats. JF - Alcoholism, clinical and experimental research AU - Little, P J AU - Kuhn, C M AU - Wilson, W A AU - Swartzwelder, H S AD - Department of Pharmacology, Veterans Administration Medical Center, Durham , North Carolina, USA. Y1 - 1996/11// PY - 1996 DA - November 1996 SP - 1346 EP - 1351 VL - 20 IS - 8 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Reaction Time -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Age Factors KW - Metabolic Clearance Rate -- physiology KW - Male KW - Ethanol -- pharmacokinetics KW - Reflex -- drug effects KW - Ethanol -- toxicity KW - Motor Activity -- drug effects KW - Postural Balance -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78586921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Differential+effects+of+ethanol+in+adolescent+and+adult+rats.&rft.au=Little%2C+P+J%3BKuhn%2C+C+M%3BWilson%2C+W+A%3BSwartzwelder%2C+H+S&rft.aulast=Little&rft.aufirst=P&rft.date=1996-11-01&rft.volume=20&rft.issue=8&rft.spage=1346&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-18 N1 - Date created - 1997-03-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Truncation of the amino terminus of PTH alters its anabolic activity on bone in vivo. AN - 78547328; 8922645 AB - In vitro studies of parathyroid hormone (PTH) structure and function have suggested that the anabolic effect of PTH on bone requires the presence of amino acid residues 28-34 (domains for protein kinase C activation and mitogenic activity), but not amino acid residues 1-7 (adenylate cyclase activation domain). We have tested this hypothesis with in vivo studies of human PTH (hPTH) analogs. Serum biomarkers and selected histomorphometric parameters of bone formation and resorption were assessed in adult, female, Sprague-Dawley rats following 19 daily injections of vehicle, 10 micrograms/kg body weight (bw) of hPTH(1-38), or a dose range of 10, 40, and 100 micrograms/100 g bw of hPTH(2-38) or hPTH(3-38). Treatment with hPTH(1-38) increased serum osteocalcin, the percentage of osteoblast surface, percentage of osteoid surface, percentage of bone volume, trabecular thickness, and bone formation rate, while it decreased the percentage of osteoclast surface. The hPTH(2-38) fragment exhibited 10%-25% of the in vivo anabolic activity of hPTH(1-38), while it had no effect on the percentage of osteoclast surface. The hPTH(3-38) fragment exhibited no biological activity on bone. In contrast, serum INS-PTH (intact-N-terminal specific PTH) levels were similarly and significantly increased above control in rats treated with hPTH(1-38), hPTH(2-38), or hPTH(3-38) at the same dose. This preliminary finding suggests that the differential activity of these peptides on bone is not due to differences in the circulating level of immunoreactive PTH (intact and amino-terminal fragments of PTH from endogenous and exogenous sources) several hours after PTH injection. However, we can draw no conclusion regarding the relative clearance rates of these peptides. Last, because hPTH(3-38) was without any detectable biological activity on rat bone in vivo, its mitogenic activity was confirmed in two osteoblast-like cell lines. In summary, the anabolic effect of hPTH(1-38) on bone in vivo was (1) diminished by removal of amino acid residue 1, and (2) abolished by the removal of amino acid residues 1 and 2. Although these findings suggest that the therapeutic benefits of exogenous PTH administration may depend upon activation of not only protein kinase C, but also adenylate cyclase, they do not rule out a differential PTH response due to other causes, e.g., metabolic inactivation. JF - Bone AU - Hilliker, S AU - Wergedal, J E AU - Gruber, H E AU - Bettica, P AU - Baylink, D J AD - Jerry L. Pettis Veterans' Administration Medical Center, Loma Linda, CA, USA. Y1 - 1996/11// PY - 1996 DA - November 1996 SP - 469 EP - 477 VL - 19 IS - 5 SN - 8756-3282, 8756-3282 KW - Biomarkers KW - 0 KW - Mitogens KW - Parathyroid Hormone KW - Osteocalcin KW - 104982-03-8 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Bone Resorption -- prevention & control KW - Humans KW - Mitogens -- toxicity KW - Osteoblasts -- cytology KW - Osteocalcin -- blood KW - Rats KW - Protein Kinase C -- metabolism KW - Osteoblasts -- drug effects KW - Rats, Sprague-Dawley KW - Tumor Cells, Cultured KW - Body Weight -- drug effects KW - Enzyme Activation -- drug effects KW - Cell Differentiation -- drug effects KW - Female KW - Bone Density -- drug effects KW - Parathyroid Hormone -- pharmacology KW - Bone Development -- drug effects KW - Parathyroid Hormone -- toxicity KW - Parathyroid Hormone -- blood KW - Biomarkers -- blood KW - Parathyroid Hormone -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78547328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bone&rft.atitle=Truncation+of+the+amino+terminus+of+PTH+alters+its+anabolic+activity+on+bone+in+vivo.&rft.au=Hilliker%2C+S%3BWergedal%2C+J+E%3BGruber%2C+H+E%3BBettica%2C+P%3BBaylink%2C+D+J&rft.aulast=Hilliker&rft.aufirst=S&rft.date=1996-11-01&rft.volume=19&rft.issue=5&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Bone&rft.issn=87563282&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-02-20 N1 - Date created - 1997-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Retardation of Aging by Caloric Restriction: Studies in Rodents and Primates AN - 755136284; 13645786 AB - Caloric restriction (CR), which has been investigated by gerontologists for more than 60 yr, provides the only intervention tested to date in mammals (typically mice and rats) that repeatedly and strongly increases maximum life span while retarding the appearance of age-associated pathologic and biologic changes. Although the large majority of rodent studies have initiated CR early in life (1-3 mo of age), CR started in midadulthood (at 12 mo) also extends maximum life span in mice. Two main questions now face gerontologists investigating CR. By what mechanisms does CR retard aging and disease processes in rodents? There is evidence to suggest that age-associated increases in oxidative damage may represent a primary aging process that is attenuated by CR. Will CR exert similar actions in primates? Studies in rhesus monkeys subjected to CR and limited human epidemiological data support the notion of human translatability. However, no matter what the answers are to these questions, the prolongation of the health span and life span of rodents by CR has major implications for many disciplines, including Toxicologic Pathology, and raises important questions about the desirability of ad libitum feeding. JF - Toxicologic Pathology AU - Weindruch, Richard AD - Department of Medicine, University of Wisconsin, and Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center 2500 Overlook Terrace, Madison, Wisconsin 53705, rhweindr@facstaff.wisc.edu Y1 - 1996/11// PY - 1996 DA - Nov 1996 SP - 742 EP - 745 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 24 IS - 6 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755136284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=The+Retardation+of+Aging+by+Caloric+Restriction%3A+Studies+in+Rodents+and+Primates&rft.au=Weindruch%2C+Richard&rft.aulast=Weindruch&rft.aufirst=Richard&rft.date=1996-11-01&rft.volume=24&rft.issue=6&rft.spage=742&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F019262339602400618 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1177/019262339602400618 ER - TY - JOUR T1 - Attitudes of Oregon Psychiatrists toward Physician-Assisted Suicide AN - 61442081; 9705341 AB - Psychiatrists' attitudes toward physician-assisted suicide (PAS) & the factors affecting & the influence of those attitudes on their professional behavior were examined through mail survey data from 321 licensed psychiatrists in OR. Of respondents (Rs), 18% viewed PAS as never morally acceptable, 13% viewed it as not personally morally acceptable, but a manner for the affected individual to decide, & 69% viewed PAS as probably morally acceptable under certain circumstances. Over 50% of Rs favored passage of OR's assisted-suicide initiative, & nearly 75% reported they might consider a physician-assisted suicide option if threatened with a terminal illness. Psychiatrists' position on legalization of assisted suicide influenced the likelihood that they would agree to evaluate patients requesting assisted suicide & clinical practice with a patient desiring assisted suicide. Only 6% believed that a single evaluation would allow them to make a definitive determination about the impact of a psychiatric disorder on the judgment of a patient requesting assisted suicide. 4 Tables, 21 References. Adapted from the source document. JF - The American Journal of Psychiatry AU - Ganzini, Linda AU - Fenn, Darien S AU - Lee, Melinda A AU - Heintz, Ronald T AU - Bloom, Joseph D AD - Psychiatry Service Portland Veterans Administration Medical Center, PO Box 1034 OR 97207 ganzinil@ohsu.edu Y1 - 1996/11// PY - 1996 DA - November 1996 SP - 1469 EP - 1475 VL - 153 IS - 11 SN - 0002-953X, 0002-953X KW - physician-assisted suicide, psychiatrists' attitudes, Oregon KW - survey KW - Professional Ethics KW - Oregon KW - Morality KW - Bioethics KW - Psychiatrists KW - Euthanasia KW - article KW - 2499: policy, planning, forecasting; sociology of ethics & ethical decision making KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61442081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Attitudes+of+Oregon+Psychiatrists+toward+Physician-Assisted+Suicide&rft.au=Ganzini%2C+Linda%3BFenn%2C+Darien+S%3BLee%2C+Melinda+A%3BHeintz%2C+Ronald+T%3BBloom%2C+Joseph+D&rft.aulast=Ganzini&rft.aufirst=Linda&rft.date=1996-11-01&rft.volume=153&rft.issue=11&rft.spage=1469&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Euthanasia; Psychiatrists; Morality; Bioethics; Professional Ethics; Oregon ER - TY - JOUR T1 - A Low Vision Reading Comprehension Test AN - 58347359; 9711101 AB - The development of the Low Vision Reading Comprehension Assessment (LVRCA) for those with macular degeneration & reading with magnification is described. The test, an 18-sentence, 9-minute, cloze task (2 equivalent forms), was designed to measure understanding of print reading, taking into account visual, structural, & contextual criteria. Font (Palatino) sizes varied from 9 to 24 point, & content was arranged in order of difficulty according to reading levels & conceptual difficulty. To determine validity & reliability of the LVRCA, subjects with macular degeneration (N = 50, aged 28-86) were given a test battery that included the LVRCA. A high level of reliability was found. 1 Table, 3 Figures, 19 References. Adapted from the source document JF - Journal of Visual Impairment and Blindness AU - Watson, Gale R AU - Wright, Valjean AU - Long, Sharon AU - De L'Aune, William AD - Research & Development Center Atlanta Veterans Administration Medical Center, 1670 Clairmont Rd Decatur GA 30033 GW1@delph.com Y1 - 1996/11// PY - 1996 DA - November 1996 SP - 486 EP - 494 VL - 90 IS - 6 SN - 0145-482X, 0145-482X KW - Low Vision Reading Comprehension Assessment descriptions KW - test battery KW - macular degeneration adults KW - Reading Tests (71550) KW - Vision Disorders (94350) KW - Test Validity and Reliability (88800) KW - article KW - 4120: applied linguistics; reading testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58347359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Visual+Impairment+and+Blindness&rft.atitle=A+Low+Vision+Reading+Comprehension+Test&rft.au=Watson%2C+Gale+R%3BWright%2C+Valjean%3BLong%2C+Sharon%3BDe+L%27Aune%2C+William&rft.aulast=Watson&rft.aufirst=Gale&rft.date=1996-11-01&rft.volume=90&rft.issue=6&rft.spage=486&rft.isbn=&rft.btitle=&rft.title=Journal+of+Visual+Impairment+and+Blindness&rft.issn=0145482X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JVIBDM N1 - SubjectsTermNotLitGenreText - Vision Disorders (94350); Reading Tests (71550); Test Validity and Reliability (88800) ER - TY - JOUR T1 - Evidence against the influence of aging on distortion-product otoacoustic emissions. AN - 85245995; pmid-8898270 AB - Previous research has reported reduced otoacoustic emission amplitude as a function of age. In each study, however, interpretation of findings was confounded by age-related hearing loss. The present study was designed to re-evaluate the contribution of age and peripheral hearing loss on the prevalence and amplitude of distortion-product otoacoustic emissions (DPOAEs) by controlling for degree of peripheral hearing loss. Twenty subjects were divided into four age ranges. All subjects in each group had 15 dB HL or better thresholds from 0.25 through 8 kHz and normal immittance findings. DPOAE audiograms recorded at three intensity levels and input/output functions recorded at six discrete frequencies showed no significant differences in amplitude or noise level between age groups. Findings indicate that when the degree of peripheral hearing loss is adequately controlled, there is no direct effect of advanced age on DPOAE measures. Clinical implications are discussed. JF - Journal of the American Academy of Audiology AU - Strouse, A L AU - Ochs, M T AU - Hall, J W AD - Veterans' Administration Medical Center, Mountain Home, Tennessee 37684, USA.; Department of Otolaryngology-Head and Neck Surgery, University of Texas Medical School, Houston. PY - 1996 SP - 339 EP - 345 VL - 7 IS - 5 SN - 1050-0545, 1050-0545 KW - Cochlea KW - Age Factors KW - Comparative Study KW - Hair Cells KW - Audiometry KW - Auditory Threshold KW - Human KW - Adult KW - Middle Age KW - Aged KW - Male KW - Female KW - Aging KW - Acoustic Stimulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85245995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Evidence+against+the+influence+of+aging+on+distortion-product+otoacoustic+emissions.&rft.au=Strouse%2C+A+L%3BOchs%2C+M+T%3BHall%2C+J+W&rft.aulast=Strouse&rft.aufirst=A&rft.date=1996-10-01&rft.volume=7&rft.issue=5&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Feeding patterns of rats chronically ingesting an ethanol-containing liquid diet. AN - 78517923; 8904982 AB - We compared the feeding patterns of rats ingesting a 36% ethanol-containing liquid diet for 30 days with those of rats pair-fed an isocaloric liquid control diet or provided control diet or ground rat chow ad libitum. Ethanol-fed rats consumed fewer calories per day and gained less body weight than rats fed control diets ad libitum. Daily caloric intakes were approximately 50% lower during the first 10 days and 20% thereafter. Lower intakes in ethanol-fed rats occurred through a decrease in mean meal size rather than number of meals per day, although meals were more evenly distributed diurnally. Pair-fed rats ingested most of their food in one or two meals within a few hours of presentation. In a related experiment, a 4-hr duodenal infusion of ethanol at a rate comparable to that of ethanol ingestion resulted in plasma ethanol levels of 28 +/- 4 mM and suppressed 5-hr intake by approximately 40% by increasing the mean postmeal interval and satiety ratio. These results suggest that the suppressive effect of ethanol ingestion on food intake may be mediated in part by a post-gastric mechanism of ethanol action. JF - Alcoholism, clinical and experimental research AU - Reidelberger, R D AU - Tuma, D J AU - Woltman, T A AU - Donohue, T M AD - Alcohol Research Center, Veterans Administration Medical Center, Omaha, Nebraska 68105, USA. Y1 - 1996/10// PY - 1996 DA - October 1996 SP - 1275 EP - 1282 VL - 20 IS - 7 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Body Weight -- drug effects KW - Energy Intake -- drug effects KW - Male KW - Satiety Response -- drug effects KW - Ethanol -- pharmacokinetics KW - Ethanol -- toxicity KW - Alcoholism -- physiopathology KW - Feeding Behavior -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78517923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Feeding+patterns+of+rats+chronically+ingesting+an+ethanol-containing+liquid+diet.&rft.au=Reidelberger%2C+R+D%3BTuma%2C+D+J%3BWoltman%2C+T+A%3BDonohue%2C+T+M&rft.aulast=Reidelberger&rft.aufirst=R&rft.date=1996-10-01&rft.volume=20&rft.issue=7&rft.spage=1275&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-03 N1 - Date created - 1997-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Efficacy and safety of repeated intravenous doses of ibutilide for rapid conversion of atrial flutter or fibrillation. Ibutilide Repeat Dose Study Investigators. AN - 78383887; 8840852 AB - Currently available antiarrhythmic drugs have limited efficacy for acute termination of atrial fibrillation and flutter, especially if the arrhythmia is not of recent onset. The purpose of this multicenter study was to determine the efficacy and safety of repeated doses of intravenous ibutilide, a class III antiarrhythmic drug, in terminating atrial fibrillation or flutter. Two hundred sixty-six patients with sustained atrial fibrillation (n = 133) or flutter (n = 133), with an arrhythmia duration of 3 hours to 45 days, were randomized to receive up to two 10-minute infusions, separated by 10 minutes, of ibutilide (1.0 and 0.5 mg or 1.0 and 1.0 mg) or placebo. The conversion rate was 47% after ibutilide and 2% after placebo (P < .0001). The two ibutilide dosing regimens did not differ in conversion efficacy (44% versus 49%). Efficacy was higher in atrial flutter than fibrillation (63% versus 31%, P < .0001). In atrial fibrillation but not flutter, conversion rates were higher in patients with a shorter arrhythmia duration or a normal left atrial size. Arrhythmia termination occurred a mean of 27 minutes after start of the infusion. Of 180 ibutilide-treated patients, 15 (8.3%) developed polymorphic ventricular tachycardia during or soon after the infusion. The arrhythmia required cardioversion in 3 patients (1.7%) and was nonsustained in 12 patients (6.7%). Intravenous ibutilide given in repeated doses is effective in rapidly terminating atrial fibrillation and flutter and under monitored conditions is an alternative to current cardioversion options. JF - Circulation AU - Stambler, B S AU - Wood, M A AU - Ellenbogen, K A AU - Perry, K T AU - Wakefield, L K AU - VanderLugt, J T AD - West Roxbury Veterans Administration Medical Center, Cardiology Section, MA 02132, USA. Y1 - 1996/10/01/ PY - 1996 DA - 1996 Oct 01 SP - 1613 EP - 1621 VL - 94 IS - 7 SN - 0009-7322, 0009-7322 KW - Anti-Arrhythmia Agents KW - 0 KW - Sulfonamides KW - ibutilide KW - 2436VX1U9B KW - Abridged Index Medicus KW - Index Medicus KW - Hemodynamics -- drug effects KW - Double-Blind Method KW - Injections, Intravenous KW - Dose-Response Relationship, Drug KW - Humans KW - Aged KW - Prospective Studies KW - Tachycardia, Ventricular -- chemically induced KW - Treatment Outcome KW - Forecasting KW - Middle Aged KW - Female KW - Male KW - Electrocardiography -- drug effects KW - Sulfonamides -- adverse effects KW - Atrial Flutter -- drug therapy KW - Atrial Fibrillation -- drug therapy KW - Atrial Flutter -- physiopathology KW - Sulfonamides -- administration & dosage KW - Atrial Fibrillation -- physiopathology KW - Sulfonamides -- therapeutic use KW - Anti-Arrhythmia Agents -- adverse effects KW - Anti-Arrhythmia Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78383887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation&rft.atitle=Efficacy+and+safety+of+repeated+intravenous+doses+of+ibutilide+for+rapid+conversion+of+atrial+flutter+or+fibrillation.+Ibutilide+Repeat+Dose+Study+Investigators.&rft.au=Stambler%2C+B+S%3BWood%2C+M+A%3BEllenbogen%2C+K+A%3BPerry%2C+K+T%3BWakefield%2C+L+K%3BVanderLugt%2C+J+T&rft.aulast=Stambler&rft.aufirst=B&rft.date=1996-10-01&rft.volume=94&rft.issue=7&rft.spage=1613&rft.isbn=&rft.btitle=&rft.title=Circulation&rft.issn=00097322&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-11-29 N1 - Date created - 1996-11-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Circulation. 1996 Oct 1;94(7):1499-502 [8840835] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Is Prefrontal Cortex Involved in Cued Recall? A Neuropsychological Test of PET Findings AN - 58314754; 9700144 AB - The role of the frontal lobes in memory is investigated using a cued recall task. Based on evidence from positron emission tomography (PET) studies, E. Tulving et al (1994) have proposed that the left prefrontal cortex is involved in encoding novel information for episodic memory, whereas the right prefrontal cortex is involved in episodic memory retrieval. The predictions of this hypothesis were tested on patients with right & left frontal lesions & control Ss (N = 16, 5, & 15, respectively, aged 20-78). All Ss were presented with study lists of words & instructed to indicate if they represented living vs nonliving or abstract vs concrete objects. This was followed by a stem completion task in which 50% of the items could be completed with words from the study list. The following results were found: (1) Both controls & patients showed repetition priming effects. (2) In cued recall, right frontal Ss performed as well as controls, whereas left frontal Ss were impaired in the first but not the second experiment. It is suggested that the activation of prefrontal cortex in PET experiments, in contrast with the lack of impairment of right frontal Ss in cued recall tasks, could have various explanations including the use of different encoding tasks, & reliance on familiarity rather than explicit recall by the frontal Ss, or brain reorganization in the frontal Ss. The regions of prefrontal cortex activated in PET studies are concluded to be unnecessary for the performance of cued recall tasks by frontal patients. 6 Tables, 2 Figures, 45 References. S. Casey JF - Neuropsychologia AU - Swick, Diane AU - Knight, Robert T AD - Dept Neurology VA Medical Center, 150 Muir Rd Martinez CA 94553 [Fax: 510-229-2315; mailto:diane@marva4.ncsc.med.va.gov] Y1 - 1996/10// PY - 1996 DA - October 1996 SP - 1019 EP - 1028 VL - 34 IS - 10 SN - 0028-3932, 0028-3932 KW - cued recall, frontal lobe role KW - semantic category/stem completion tasks KW - brain-damaged patients KW - Cerebral Dominance (11500) KW - Brain Damage (09400) KW - Aided Recall (01250) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58314754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychologia&rft.atitle=Is+Prefrontal+Cortex+Involved+in+Cued+Recall%3F+A+Neuropsychological+Test+of+PET+Findings&rft.au=Swick%2C+Diane%3BKnight%2C+Robert+T&rft.aulast=Swick&rft.aufirst=Diane&rft.date=1996-10-01&rft.volume=34&rft.issue=10&rft.spage=1019&rft.isbn=&rft.btitle=&rft.title=Neuropsychologia&rft.issn=00283932&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - NUPSA6 N1 - SubjectsTermNotLitGenreText - Cerebral Dominance (11500); Brain Damage (09400); Aided Recall (01250) ER - TY - JOUR T1 - Effect of the stress level achieved during symptom-limited exercise technetium-99m sestamibi myocardial tomography on the detection of coronary artery disease AN - 21081615; 11283143 AB - Background: The stress level achieved during exercise thallium-201 myocardial imaging may influence its sensitivity for detecting coronary artery disease (CAD). The effect of exercise adequacy on the accuracy of technetium-99m sestamibi (MIBI) imaging has not been studied. Hypothesis: The study was undertaken to assess the effect of exercise level achieved on sensitivity for detecting CAD. Methods: A consecutive series of 250 patients (mean age 60 ± 10 years) with CAD by angiography underwent symptom-limited exercise MIBI single-photon emission computed tomography. Single-vessel CAD was found in 66 patients, double-vessel CAD in 84, triple-vessel CAD in 80, and left main disease in 20. Results: No significant differences were found in sensitivities of an abnormal MIBI scan or a reversible defect among 102 patients reaching 85% of age-predicted heart rate and 148 who did not (82 vs. 89% and 66 vs. 70%, respectively, p = NS). Patients (n = 128) able to exercise 6 min had a higher incidence of abnormal scans and reversible defects than 122 patients with a greater exercise duration (91 vs. 82% and 75 vs. 61 %, respectively, both p6 min (89 vs. 66%, p6 min is associated with a significantly higher MIBI abnormality rate than a duration of >6 min, possibly reflecting the effect of myocardial ischemic burden on exercise ventricular function. Regardless of level of stress or its duration, exercise MIBI tomography improves the sensitivity for CAD detection compared with stress-induced ischemic ST depression. JF - Clinical Cardiology (Hoboken) AU - Stratmann, Henry G AU - Younis, Liwa T AU - Wittry, Mark D AU - Amato, Maryellen AU - Mark, Alexander L AU - Miller, D Douglas AD - Department of Internal Medicine, Division of Cardiology, St. Louis Veterans Administration Medical Center and St. Louis University Health Sciences Center, St. Louis, Missouri, USA Y1 - 1996/10// PY - 1996 DA - Oct 1996 SP - 787 EP - 792 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 19 IS - 10 SN - 0160-9289, 0160-9289 KW - Physical Education Index KW - Exercise (duration) KW - Scanning KW - Heart rate KW - Stress KW - Patients KW - Exercise (effects) KW - Diseases KW - Exercise KW - Circulatory system KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21081615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cardiology+%28Hoboken%29&rft.atitle=Effect+of+the+stress+level+achieved+during+symptom-limited+exercise+technetium-99m+sestamibi+myocardial+tomography+on+the+detection+of+coronary+artery+disease&rft.au=Stratmann%2C+Henry+G%3BYounis%2C+Liwa+T%3BWittry%2C+Mark+D%3BAmato%2C+Maryellen%3BMark%2C+Alexander+L%3BMiller%2C+D+Douglas&rft.aulast=Stratmann&rft.aufirst=Henry&rft.date=1996-10-01&rft.volume=19&rft.issue=10&rft.spage=787&rft.isbn=&rft.btitle=&rft.title=Clinical+Cardiology+%28Hoboken%29&rft.issn=01609289&rft_id=info:doi/10.1002%2Fclc.4960191006 LA - English DB - Physical Education Index N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Scanning; Exercise (duration); Heart rate; Stress; Patients; Exercise; Diseases; Exercise (effects); Circulatory system DO - http://dx.doi.org/10.1002/clc.4960191006 ER - TY - JOUR T1 - Utilization of Acute Inpatient Services for Alcohol Detoxification AN - 1761709962; 199700391 AB - Investigates the appropriateness of intensive inpatient alcohol detoxification for Veterans Affairs (VA) patients, drawing on medical record data from a national random sample of 144 alcoholism-related medical admissions to 35 VA inpatient medical & surgical units. Results indicate that the majority of patients could have been treated on an outpatient or less-intensive basis. However, inpatient medical detoxification services appear to be appropriate for those at risk for potential life-threatening complications of withdrawal, eg, delirium tremens, or those with concurrent associated medical conditions, eg, pancreatitis, gastrointestinal bleeding, or cirrhosis. 1 Table, 27 References. Adapted from the source document. JF - The Journal of Mental Health Administration AU - Booth, Brenda M AU - Blow, Frederic C AU - Ludke, Robert L AU - Ross, Robin L AD - HSR&D Field Program Mental Health Veterans Administration Medical Center, 2200 Fort Roots Dr North Little Rock AR 72114 Y1 - 1996/10// PY - 1996 DA - October 1996 SP - 366 EP - 374 VL - 23 IS - 4 SN - 0092-8623, 0092-8623 KW - alcohol detoxification treatment, inpatient service appropriateness KW - medical records KW - Veterans Affairs admissions KW - Detoxification KW - Alcoholism KW - Treatment Methods KW - Health Care Utilization KW - article KW - 6129: addiction KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761709962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Mental+Health+Administration&rft.atitle=Utilization+of+Acute+Inpatient+Services+for+Alcohol+Detoxification&rft.au=Booth%2C+Brenda+M%3BBlow%2C+Frederic+C%3BLudke%2C+Robert+L%3BRoss%2C+Robin+L&rft.aulast=Booth&rft.aufirst=Brenda&rft.date=1996-10-01&rft.volume=23&rft.issue=4&rft.spage=366&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Mental+Health+Administration&rft.issn=00928623&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Detoxification; Alcoholism; Health Care Utilization; Treatment Methods ER - TY - JOUR T1 - Open pilot study of the addition of sulfasalazine to methotrexate in patients with rheumatoid arthritis inadequately controlled with methotrexate alone. AN - 1037660499; 19078078 AB - The safety and efficacy of the sequential addition of sulfasalazine to baseline methotrexate was assessed in patients with active rheumatoid arthritis inadequately controlled by methotrexate alone. Nineteen patients were recruited in a pilot, prospective, open label, uncontrolled clinical trial. One patient was lost to follow-up, four dropped out due to toxicity, one dropped out due to inefficacy, and five violated the protocol. A modified intent-to-treat analysis was performed by carrying forward the clinical data before drop-out or protocol violation to the final visit for the 18 evaluable patients. Swollen and tender joint counts, physicians's and patient's global scores were significantly improved (p /= 20% improvement and 26% (5/19) showed >/= 50% improvement in 4 or more clinical parameters at 6 month's follow-up. Rheumatoid factor negative patients were more likely (p < 0.025) to complete the trial. A controlled clinical trial will be necessary to determine the effectiveness of this combination and the value of sequential addition chemotherapy in patients with recalcitrant rheumatoid arthritis. JF - Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases AU - Liang, G C AU - Lessard, J AU - Pope, R M AD - Division of Arthritis-Connective Tissue Diseases, Department of Medicine, Northwestern University, and the Veterans Administration Lakeside Medical Center, Chicago, Illinois (G.C.L., R.M.P.), and the Division of Rheumatology, Department of Medicine, Grand Forks Clinic, and the University of North Dakota, Grand Forks, North Dakota (J.L.). Y1 - 1996/10// PY - 1996 DA - October 1996 SP - 244 EP - 250 VL - 2 IS - 5 SN - 1076-1608, 1076-1608 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1037660499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+rheumatology+%3A+practical+reports+on+rheumatic+%26+musculoskeletal+diseases&rft.atitle=Open+pilot+study+of+the+addition+of+sulfasalazine+to+methotrexate+in+patients+with+rheumatoid+arthritis+inadequately+controlled+with+methotrexate+alone.&rft.au=Liang%2C+G+C%3BLessard%2C+J%3BPope%2C+R+M&rft.aulast=Liang&rft.aufirst=G&rft.date=1996-10-01&rft.volume=2&rft.issue=5&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+rheumatology+%3A+practical+reports+on+rheumatic+%26+musculoskeletal+diseases&rft.issn=10761608&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Systemic absorption and toxicity from topically administered lidocaine during transesophageal echocardiography. AN - 78472598; 8887875 AB - This report describes the cases of three patients who had central nervous system toxicity from locally administered lidocaine during transesophageal echocardiography. Parenteral sedation was not employed. Serum levels of lidocaine were obtained after the procedure in all three patients, who recovered spontaneously and suffered no permanent ill effects. Medical conditions such as congestive heart failure and diminished hepatic function or concomitant use of lidocaine analogs may predispose patients to the toxic side effects of locally administered lidocaine. Extreme care and close monitoring of patients are warranted when topical lidocaine anesthetic is employed in the setting of delayed lidocaine clearance. JF - Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography AU - Sharma, S C AU - Rama, P R AU - Miller, G L AU - Coccio, E B AU - Coulter, L J AD - Department of Medicine, Veterans Administration Medical Center, Brown University School of Medicine, Providence, RI, USA. PY - 1996 SP - 710 EP - 711 VL - 9 IS - 5 SN - 0894-7317, 0894-7317 KW - Anesthetics, Local KW - 0 KW - Lidocaine KW - 98PI200987 KW - Index Medicus KW - Humans KW - Aged KW - Male KW - Female KW - Administration, Topical KW - Lidocaine -- administration & dosage KW - Echocardiography, Transesophageal KW - Anesthetics, Local -- administration & dosage KW - Anesthetics, Local -- toxicity KW - Lidocaine -- toxicity KW - Anesthetics, Local -- pharmacokinetics KW - Lidocaine -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78472598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Echocardiography+%3A+official+publication+of+the+American+Society+of+Echocardiography&rft.atitle=Systemic+absorption+and+toxicity+from+topically+administered+lidocaine+during+transesophageal+echocardiography.&rft.au=Sharma%2C+S+C%3BRama%2C+P+R%3BMiller%2C+G+L%3BCoccio%2C+E+B%3BCoulter%2C+L+J&rft.aulast=Sharma&rft.aufirst=S&rft.date=1996-09-01&rft.volume=9&rft.issue=5&rft.spage=710&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Echocardiography+%3A+official+publication+of+the+American+Society+of+Echocardiography&rft.issn=08947317&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-02-12 N1 - Date created - 1997-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol use in retirement communities. AN - 78296810; 8790236 AB - Anecdotal reports and two previous studies suggest that retirement communities have a particularly high prevalence of heavy drinking. The objective of this study was to verify or refute this finding and to identify characteristics associated with heavy drinking in retirement communities. This cross-sectional study used a mailed survey to gather information from three retirement communities in suburban Milwaukee, Wisconsin. The questionnaire included alcohol use questions adapted from the Khavari questionnaire and the CAGE questionnaire to screen for alcohol abuse. Three hundred seventeen of 454 independent residents of the retirement communities completed and returned surveys for a response rate of 70%. Mean age of respondents was 83 +/- 6 years, 100% were white, 77% were female. Forty-seven percent used some alcohol, 15% had one to six drinks per week, 8% had seven or more drinks per week. Only two people screened positive on the CAGE questionnaire for abusive drinking. The majority of drinkers had decreased alcohol use since moving to the community. Male sex, socialization, lack of religious affiliation, and smoking were factors whose percentages increased significantly with increasing alcohol use. Although drinkers were more likely to smoke cigarettes, no indicators suggested that they were less healthy than abstainers. Despite the advanced age of this population, regular alcohol use was prevalent. In contrast to previous reports from retirement communities, heavy and abusive drinking were uncommon by our measures, perhaps because of the older age and female predominance of the sample. Drinking appears to be associated with more social contacts and, possibly, better health status. JF - Journal of the American Geriatrics Society AU - Adams, W L AD - Medical College of Wisconsin, Zablocki, Veterans Administration Medical Center, Milwaukee, USA. Y1 - 1996/09// PY - 1996 DA - September 1996 SP - 1082 EP - 1085 VL - 44 IS - 9 SN - 0002-8614, 0002-8614 KW - Index Medicus KW - Humans KW - Suburban Health KW - Health Status KW - Aged KW - Population Surveillance KW - Cross-Sectional Studies KW - Aged, 80 and over KW - Risk Factors KW - Wisconsin -- epidemiology KW - Surveys and Questionnaires KW - Female KW - Male KW - Prevalence KW - Housing for the Elderly KW - Alcoholism -- epidemiology KW - Alcohol Drinking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78296810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Alcohol+use+in+retirement+communities.&rft.au=Adams%2C+W+L&rft.aulast=Adams&rft.aufirst=W&rft.date=1996-09-01&rft.volume=44&rft.issue=9&rft.spage=1082&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-10-18 N1 - Date created - 1996-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns. AN - 78285369; 8781481 AB - We have previously developed a canine in vivo model of the long QT syndrome (LQTS) using the neurotoxin anthopleurin A (AP-A), which acts by slowing sodium channel inactivation. The recent discovery of a genetic mutation in the cardiac sodium channel in some patients with the congenital LQTS, resulting in abnormal gating behavior similar to sodium channels exposed to AP-A, provides a strong endorsement of this animal model as a valid surrogate to the clinical syndrome of LQTS. In the present study, we conducted high-resolution tridimensional isochronal mapping of both activation and repolarization patterns in puppies exposed to AP-A that developed LQTS and polymorphic ventricular tachyarrhythmias (VTs). To map repolarization, we measured activation-recovery intervals (ARIs) using multiple unipolar extracellular electrograms. We demonstrated, for the first time in vivo, the existence of spatial dispersion of repolarization in the ventricular wall and differences in regional recovery in response to cycle-length changes that were markedly exaggerated after AP-A administration. Analysis of tridimensional activation patterns showed that the initial beat of polymorphic VT consistently arose as focal activity from a subendocardial site, whereas subsequent beats were due to successive subendocardial focal activity, reentrant excitation, or a combination of both mechanisms. Reentrant excitation was due to infringement of a focal activity on the spatial dispersion of repolarization, resulting in functional conduction block and circulating wave fronts. The polymorphic QRS configuration of VT in the LQTS was due to either changing the site of origin of focal activity, resulting in varying activation patterns, or varying orientations of circulating wave fronts. JF - Circulation research AU - el-Sherif, N AU - Caref, E B AU - Yin, H AU - Restivo, M AD - Department of Medicine, State University of New York Health Science Center, Brooklyn 11203, USA. el-sherif.nabil@brooklyn.va.gov Y1 - 1996/09// PY - 1996 DA - September 1996 SP - 474 EP - 492 VL - 79 IS - 3 SN - 0009-7330, 0009-7330 KW - Cardiotonic Agents KW - 0 KW - Peptides KW - anthopleurin-A KW - 60880-63-9 KW - Index Medicus KW - Animals KW - Electrocardiography KW - Dogs KW - Heart -- drug effects KW - Cardiotonic Agents -- pharmacology KW - Electrophysiology KW - Peptides -- pharmacology KW - Tachycardia, Ventricular -- physiopathology KW - Long QT Syndrome -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78285369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation+research&rft.atitle=The+electrophysiological+mechanism+of+ventricular+arrhythmias+in+the+long+QT+syndrome.+Tridimensional+mapping+of+activation+and+recovery+patterns.&rft.au=el-Sherif%2C+N%3BCaref%2C+E+B%3BYin%2C+H%3BRestivo%2C+M&rft.aulast=el-Sherif&rft.aufirst=N&rft.date=1996-09-01&rft.volume=79&rft.issue=3&rft.spage=474&rft.isbn=&rft.btitle=&rft.title=Circulation+research&rft.issn=00097330&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-10-24 N1 - Date created - 1996-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - RPRT T1 - Clinical assessment and treatment of PTSD related to mustard gas test exposure: revised conceptual framework and practical recommendations AN - 42404809; 13810 AB - Summarizes results from studies of veterans with mustard gas and Lewisite exposure (MGE), conducted by the Department of Veterans Affairs National Center for PTSD and Office of Public Health and Environmental Hazards. Implications of these studies and observations from clinical work with veterans diagnosed with PTSD due to gas testing are presented in the form of practice guidelines for mental health clinicians. Topics include: identifying MGE veterans with undetected PTSD; intensive multimodal assessment of MGE-related PTSD; special issues in psychological assessment with MGE veterans; individualized treatment of MGE-related PTSD; resources for treatment in the Department of Veterans Affairs. [Adapted from Text] JF - White River Junction, Vermont: National Center for PTSD, September 1996. 1 pp. AU - United States Department of Veterans Affairs PY - 1996 SP - 1 PB - National Center for PTSD KW - Aged KW - Americans KW - Assessment KW - Chemical Warfare KW - Males KW - PTSD (DSM-IV) KW - Somatic Symptoms KW - Survivors KW - Toxic Contamination KW - Treatment KW - Veterans KW - United States Department of Veterans Affairs KW - Practice Guideline UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42404809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PILOTS%3A+Published+International+Literature+On+Traumatic+Stress&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=United+States+Department+of+Veterans+Affairs&rft.aulast=United+States+Department+of+Veterans+Affairs&rft.aufirst=&rft.date=1996-09-01&rft.volume=&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=Clinical+assessment+and+treatment+of+PTSD+related+to+mustard+gas+test+exposure%3A+revised+conceptual+framework+and+practical+recommendations&rft.title=Clinical+assessment+and+treatment+of+PTSD+related+to+mustard+gas+test+exposure%3A+revised+conceptual+framework+and+practical+recommendations&rft.issn=&rft_id=info:doi/ LA - English DB - PILOTS: Published International Literature On Traumatic Stress N1 - Date revised - 2016-09-15 N1 - Last updated - 2016-09-15 ER - TY - JOUR T1 - Novel role for Sp1 in phorbol ester enhancement of human platelet thromboxane receptor gene expression. AN - 78273053; 8702673 AB - Expression of platelet thromboxane receptors is transcriptionally increased during megakaryocytic differentiation stimulated by phorbol 12-myristate 13-acetate (PMA). We previously cloned and characterized the promoter region of the human thromboxane receptor gene and localized PMA-responsive elements to a region between 1.84 and 1.95 kilobase pairs (kb) 5' of the transcription initiation site (D'Angelo, D. D., Davis, M. G., Houser, W. A., Eubank, J. J., Ritchie, M. E., and Dorn, G. W., II (1995) Circ. Res. 77, 466-474). Herein we report the localization of the PMA response element to a 14-nucleotide C-rich sequence, flanked by an octanucleotide inverted repeat, located -1.938 to -1.925 kb 5' of the transcription start site of this gene. We further identify the PMA-responsive enhancer factor that binds to this C-rich sequence as Sp1. Heterologous thromboxane receptor gene promoter/thymidilate kinase reporter constructs transfected into K562 cells exhibited PMA responsiveness when the C-rich element was included with additional 3' sequence from -1.924 to -1.84 kb. However, mutations of the C-rich element that disrupted a GC box located on the inverse strand eliminated PMA responsiveness and, in gel mobility shift assays, eliminated binding of Sp1. PMA treatment of K562 cells significantly increased, by 5-fold, Sp1 binding to the C-rich element and increased both phosphorylated and nonphosphorylated Sp1 protein levels by 2-fold. Furthermore, PMA treatment transiently increased Sp1 mRNA levels prior to increasing thromboxane receptor mRNA, suggesting that up-regulation of Sp1 contributes to up-regulation of thromboxane receptors. Finally, we have detected an unidentified K562 nuclear protein that binds specifically to the sense strand of the C-rich sequence overlapping the Sp1 binding site and that, by stabilizing a double stem-loop conformation of this DNA segment, may also play a role in Sp1 regulation of this gene. These studies are the first to describe regulatory and regulated roles for Sp1 in PMA-responsive gene expression and suggest that modulation of Sp1 levels controls thromboxane receptor expression during megakaryocytic differentiation. JF - The Journal of biological chemistry AU - D'Angelo, D D AU - Oliver, B G AU - Davis, M G AU - McCluskey, T S AU - Dorn, G W AD - University of Cincinnati and the Cincinnati Veterans Administration Medical Center, Cincinnati, Ohio 45267-0542, USA. Y1 - 1996/08/16/ PY - 1996 DA - 1996 Aug 16 SP - 19696 EP - 19704 VL - 271 IS - 33 SN - 0021-9258, 0021-9258 KW - DNA Primers KW - 0 KW - DNA-Binding Proteins KW - Nuclear Proteins KW - Receptors, Thromboxane KW - Sp1 Transcription Factor KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Promoter Regions, Genetic KW - Base Sequence KW - Base Composition KW - Tumor Cells, Cultured KW - Humans KW - Molecular Sequence Data KW - Transcription, Genetic KW - Nuclear Proteins -- metabolism KW - Nucleic Acid Conformation KW - DNA-Binding Proteins -- metabolism KW - DNA Primers -- chemistry KW - Binding Sites KW - Receptors, Thromboxane -- genetics KW - Sp1 Transcription Factor -- physiology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Gene Expression Regulation -- drug effects KW - Protein Kinase C -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78273053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Novel+role+for+Sp1+in+phorbol+ester+enhancement+of+human+platelet+thromboxane+receptor+gene+expression.&rft.au=D%27Angelo%2C+D+D%3BOliver%2C+B+G%3BDavis%2C+M+G%3BMcCluskey%2C+T+S%3BDorn%2C+G+W&rft.aulast=D%27Angelo&rft.aufirst=D&rft.date=1996-08-16&rft.volume=271&rft.issue=33&rft.spage=19696&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-10-03 N1 - Date created - 1996-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance. AN - 78276789; 8770864 AB - The hexosamine biosynthetic pathway has been hypothesized to be involved in mediating some of the toxic effects of hyperglycemia. Glutamine:fructose-6-phosphate amidotransferase (GFA), the first and rate limiting enzyme of the hexosamine biosynthetic pathway, was overexpressed in skeletal muscle and adipose tissue of transgenic mice. A 2.4-fold increase of GFA activity in muscle of the transgenic mice led to weight-dependent hyperinsulinemia in random-fed mice. The hyperinsulinemic-euglycemic clamp technique confirmed that transgenic mice develop insulin resistance, with a glucose disposal rate of 68.5 +/- 3.5 compared with 129.4 +/- 9.4 mg/kg per min (P < 0.001) for littermate controls. The decrease in the glucose disposal rate of the transgenic mice is accompanied by decreased protein but not mRNA levels of the insulin-stimulated glucose transporter (GLUT4). These data support the hypothesis that excessive flux through the hexosamine biosynthesis pathway mediates adverse regulatory and metabolic effects of hyperglycemia, specifically insulin resistance of glucose disposal. These mice can serve as a model system to study the mechanism for the regulation of glucose homeostasis by hexosamines. JF - The Journal of clinical investigation AU - Hebert, L F AU - Daniels, M C AU - Zhou, J AU - Crook, E D AU - Turner, R L AU - Simmons, S T AU - Neidigh, J L AU - Zhu, J S AU - Baron, A D AU - McClain, D A AD - Veterans Administration Medical Center, Jackson, Mississippi, USA. Y1 - 1996/08/15/ PY - 1996 DA - 1996 Aug 15 SP - 930 EP - 936 VL - 98 IS - 4 SN - 0021-9738, 0021-9738 KW - Glucose Transporter Type 4 KW - 0 KW - Hemoglobin A, Glycosylated KW - Hemoglobins KW - Hexosamines KW - Monosaccharide Transport Proteins KW - Muscle Proteins KW - RNA, Messenger KW - Slc2a4 protein, mouse KW - Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) KW - EC 2.6.1.16 KW - Glucose KW - IY9XDZ35W2 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Glucose -- metabolism KW - Muscles -- metabolism KW - Gene Expression KW - Mice KW - Transgenes -- genetics KW - RNA, Messenger -- genetics KW - Adipose Tissue -- metabolism KW - Hemoglobins -- metabolism KW - Hemoglobin A, Glycosylated -- metabolism KW - Monosaccharide Transport Proteins -- genetics KW - Female KW - Male KW - Hexosamines -- metabolism KW - Insulin Resistance KW - Mice, Transgenic KW - Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78276789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Overexpression+of+glutamine%3Afructose-6-phosphate+amidotransferase+in+transgenic+mice+leads+to+insulin+resistance.&rft.au=Hebert%2C+L+F%3BDaniels%2C+M+C%3BZhou%2C+J%3BCrook%2C+E+D%3BTurner%2C+R+L%3BSimmons%2C+S+T%3BNeidigh%2C+J+L%3BZhu%2C+J+S%3BBaron%2C+A+D%3BMcClain%2C+D+A&rft.aulast=Hebert&rft.aufirst=L&rft.date=1996-08-15&rft.volume=98&rft.issue=4&rft.spage=930&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-10-10 N1 - Date created - 1996-10-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1970 Aug 15;227(5259):680-5 [5432063] J Biol Chem. 1992 Jun 15;267(17):11673-6 [1601840] Diabetes Res. 1991 Jan;16(1):37-40 [1818796] Diabetes. 1992 Apr;41(4):465-75 [1535055] J Biol Chem. 1992 Aug 25;267(24):16911-21 [1512232] Diabetes. 1992 Nov;41(11):1436-45 [1397719] Endocr Rev. 1992 Aug;13(3):415-31 [1425483] Diabetes. 1993 Sep;42(9):1289-96 [8349040] Diabetes. 1993 Sep;42(9):1333-46 [8349045] Mol Endocrinol. 1993 Aug;7(8):1041-8 [8232303] Adv Exp Med Biol. 1993;334:129-50 [8249678] Biochem Med Metab Biol. 1993 Dec;50(3):292-300 [8123294] Diabetes. 1994 Oct;43(10):1173-9 [7926284] J Clin Invest. 1995 Jan;95(1):429-32 [7814644] Anal Biochem. 1994 Oct;222(1):224-30 [7856853] Diabetes. 1995 Mar;44(3):314-20 [7883119] Hum Genet. 1995 Jul;96(1):99-101 [7607664] Diabetes. 1995 Nov;44(11):1266-73 [7589822] Diabetes. 1995 Dec;44(12):1438-46 [7589852] Biochemistry. 1979 Nov 27;18(24):5294-9 [518835] Metabolism. 1985 Aug;34(8):702-11 [4021802] J Biol Chem. 1987 Jan 5;262(1):189-97 [3539929] Diabetes Care. 1990 Jun;13(6):610-30 [2192847] J Clin Invest. 1990 Aug;86(2):542-7 [2384600] Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1701-5 [2000378] J Biol Chem. 1991 Mar 15;266(8):4706-12 [2002019] Diabetologia. 1991 Oct;34(10):763-5 [1959709] Am J Physiol. 1991 Dec;261(6 Pt 1):E782-8 [1767839] J Clin Invest. 1992 Feb;89(2):701-5 [1737857] Diabetes Care. 1992 Mar;15(3):396-417 [1559408] J Biol Chem. 1992 May 15;267(14):9718-23 [1577807] Anal Chem. 1971 Jun;43(7):880-2 [5576608] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Relationship between Objective Measures and Listeners' Judgments of the Communicative Informativeness of the Connected Discourse of Adults with Aphasia AN - 85643353; 9710140 AB - The judgment of normal listeners (N = 11) regarding the ability of subjects [Ss] with aphasia (N = 25, mean age 65.44) to communicate information during connected discourse was compared to objective measures of communicative competence. Objective measures consisted of correct information units & accurate & complete main concepts. A correct information unit was defined as an individual word that is "accurate, relevant, & informative relative to the eliciting stimulus," (Nicholas, L. E., & Brookshire, R. H., 1993 [see abstract 9411902]). An accurate & complete main concept was defined as a statement that contains "one & only one main verb" & provides "essential information portrayed in the stimulus pictures or steps in the procedures" (Nicholas & Brookshire, 1995 [see abstract 9604597]). Connected discourse samples were elicited using four pictures, two picture sequences, & two requests for procedural information (Nicolas & Brookshire, 1993). Listeners were instructed in a direct magnitude estimation method for judging aphasic Ss' discourse. All measures were strongly & positively correlated with listeners' judgments. The measure of correct information unit quantity was controlled for aphasia severity & was the most accurate predictor of perceived "informativeness." 5 Tables, 3 Figures, 17 References. D. Taylor JF - American Journal of Speech-Language Pathology AU - Doyle, Patrick J AU - Tsironas, Dina AU - Goda, Amy J AU - Kalinyak, Michelene AD - Aphasia Rehabilitation Research Laboratory & Clinic Veterans Administration Medical Center, 7180 Highland Dr Pittsburgh PA 15206 Y1 - 1996/08// PY - 1996 DA - August 1996 SP - 53 EP - 60 VL - 5 IS - 3 SN - 1058-0360, 1058-0360 KW - aphasics' connected discourse information communication KW - discourse samples, listeners' judgments KW - aphasics, mean age 65.44 KW - Aphasia (03400) KW - Communicative Competence (13650) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85643353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Speech-Language+Pathology&rft.atitle=The+Relationship+between+Objective+Measures+and+Listeners%27+Judgments+of+the+Communicative+Informativeness+of+the+Connected+Discourse+of+Adults+with+Aphasia&rft.au=Doyle%2C+Patrick+J%3BTsironas%2C+Dina%3BGoda%2C+Amy+J%3BKalinyak%2C+Michelene&rft.aulast=Doyle&rft.aufirst=Patrick&rft.date=1996-08-01&rft.volume=5&rft.issue=3&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Speech-Language+Pathology&rft.issn=10580360&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJSPFZ N1 - SubjectsTermNotLitGenreText - Communicative Competence (13650); Aphasia (03400) ER - TY - JOUR T1 - Astrocytic-ammonia interactions in hepatic encephalopathy. AN - 78655545; 8989810 JF - Seminars in liver disease AU - Norenberg, M D AD - Laboratory of Neuropathology, Veterans Administration Medical Center, Miami, Florida, USA. Y1 - 1996/08// PY - 1996 DA - August 1996 SP - 245 EP - 253 VL - 16 IS - 3 SN - 0272-8087, 0272-8087 KW - Ammonia KW - 7664-41-7 KW - Index Medicus KW - Humans KW - Brain Edema -- etiology KW - Brain Edema -- physiopathology KW - Ammonia -- metabolism KW - Hepatic Encephalopathy -- etiology KW - Ammonia -- adverse effects KW - Hepatic Encephalopathy -- physiopathology KW - Astrocytes -- chemistry KW - Astrocytes -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78655545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+liver+disease&rft.atitle=Astrocytic-ammonia+interactions+in+hepatic+encephalopathy.&rft.au=Norenberg%2C+M+D&rft.aulast=Norenberg&rft.aufirst=M&rft.date=1996-08-01&rft.volume=16&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Seminars+in+liver+disease&rft.issn=02728087&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-25 N1 - Date created - 1997-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Opioid analgesic drugs in the elderly. AN - 78405094; 8853941 AB - Much is known about opioid metabolism, which is critical in administering these agents to the elderly. Fear of addiction and tolerance are the major barriers to their use among patients as well as health-care professionals. Addressing these issues early in the initiation opioid therapy will help to alleviate these concerns. Once therapy with an opioid is initiated, the role of renal function is critical. Because many metabolites of the opioids are renally cleared and have activity either in analgesia or as undesired side effects, it is critical to be aware of the creatinine clearance (not just serum creatinine) in the elderly. The initiating doses of the opioids can be equal to that of younger patients, but the clinician should anticipate using a longer frequency of dosing interval or smaller doses during the course of therapy. Methadone, propoxyphene, and meperidine are not recommended for use in elderly people, because of the toxicity of their metabolites. Of all the unwanted effects of the opioids, the most difficult to deal with is that of constipation. Here, an aggressive approach using bowel stimulating laxatives is critical in order to prevent this problem. It is anticipated that a variety of newly formulated opioids will shortly be available for clinical use. Finally, as a better understanding of the neurophysiology of pain is gained, the clinician can anticipate having more analgesic opioids that target their receptors without agonist or antagonist effect on other opioid receptors. This will allow the clinician to better relieve pain with a minimum of unwanted side effects. JF - Clinics in geriatric medicine AU - Forman, W B AD - Albuquerque Veterans Administration Medical Center, New Mexico, USA. Y1 - 1996/08// PY - 1996 DA - August 1996 SP - 489 EP - 500 VL - 12 IS - 3 SN - 0749-0690, 0749-0690 KW - Analgesics, Opioid KW - 0 KW - Index Medicus KW - Humans KW - Aged KW - Pain -- drug therapy KW - Analgesics, Opioid -- pharmacology KW - Aging -- drug effects KW - Analgesics, Opioid -- therapeutic use KW - Analgesics, Opioid -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78405094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+geriatric+medicine&rft.atitle=Opioid+analgesic+drugs+in+the+elderly.&rft.au=Forman%2C+W+B&rft.aulast=Forman&rft.aufirst=W&rft.date=1996-08-01&rft.volume=12&rft.issue=3&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Clinics+in+geriatric+medicine&rft.issn=07490690&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-31 N1 - Date created - 1996-12-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Uncertain clinical significance of duodenal mucosal abnormalities in HIV-infected individuals. Results of a case-control study. AN - 85207539; pmid-8835891 AB - Previous research has described abnormalities of duodenal mucosal morphology in human immunodeficiency virus (HIV)-infected individuals. We wanted to determine the frequency of disturbed villus architecture and investigate its relationship to HIV-related chronic diarrhea. We conducted a case-control study of 120 HIV-infected men, 63 with and 57 without chronic diarrhea. Stools were cultured for bacteria and examined for ova and parasites; esophagogastroduodenoscopy and flexible sigmoidoscopy with mucosal biopsies were performed. Biopsy tissue was examined using light and electron microscopy to detect enteric pathogens and to evaluate mucosal morphology. The mean CD4+ cell count was 143/min3, and enteric pathogens were detected in 56 of 120 men (47%). In approximately half the study sample (57%), duodenal villus architecture was normal; complete villus flattening was not observed. We detected no association between chronic diarrhea and altered villus architecture. Although further study is needed to clarify the pathogenesis of altered duodenal mucosal morphology, our results suggest that the clinical significance of the abnormalities may be small. JF - Journal of Clinical Gastroenterology AU - Rabeneck, L AU - Genta, R M AU - Risser, J M AU - Bailey, M E AU - Clarridge, J E AU - Gyorkey, F AD - Veterans Administration Medical Center, Houston, TX 77030, USA. PY - 1996 SP - 11 EP - 14 VL - 23 IS - 1 SN - 0192-0790, 0192-0790 KW - Comparative Study KW - Duodenum KW - Nutrition Assessment KW - Human KW - HIV Enteropathy KW - Adult KW - Case-Control Studies KW - Microscopy, Electron KW - Biopsy KW - Microvilli KW - Intestinal Mucosa KW - CD4 Lymphocyte Count KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85207539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Gastroenterology&rft.atitle=Uncertain+clinical+significance+of+duodenal+mucosal+abnormalities+in+HIV-infected+individuals.+Results+of+a+case-control+study.&rft.au=Rabeneck%2C+L%3BGenta%2C+R+M%3BRisser%2C+J+M%3BBailey%2C+M+E%3BClarridge%2C+J+E%3BGyorkey%2C+F&rft.aulast=Rabeneck&rft.aufirst=L&rft.date=1996-07-01&rft.volume=23&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Attention deficit disorder in adults and nicotine dependence: psychobiological factors in resistance to recovery? AN - 78485035; 8895108 AB - The addictive nature of nicotine appears to depend on a number of psychobiological factors. This study explores the psychoactive effects of nicotine in relationship to the particular dysphoric aspects of Attention Deficit Disorder as a coincident factor in nicotine dependence and resistance to treatment. The psychological and behavioral effects of nicotine directly correspond to reduction in symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) and the neurochemical effects of nicotine are qualitatively similar to stimulant medications used to treat ADHD. Aspects of the treatment of nicotine or other addictions in such comorbid situations are discussed in the context of self-medication. JF - Journal of psychoactive drugs AU - Coger, R W AU - Moe, K L AU - Serafetinides, E A AD - Veterans Administration Medical Center, West Los Angeles, California 90077, USA. PY - 1996 SP - 229 EP - 240 VL - 28 IS - 3 SN - 0279-1072, 0279-1072 KW - Nicotinic Agonists KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Humans KW - Adult KW - Attention Deficit Disorder with Hyperactivity -- psychology KW - Nicotine -- pharmacology KW - Tobacco Use Disorder -- psychology KW - Nicotinic Agonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78485035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=Attention+deficit+disorder+in+adults+and+nicotine+dependence%3A+psychobiological+factors+in+resistance+to+recovery%3F&rft.au=Coger%2C+R+W%3BMoe%2C+K+L%3BSerafetinides%2C+E+A&rft.aulast=Coger&rft.aufirst=R&rft.date=1996-07-01&rft.volume=28&rft.issue=3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-02-18 N1 - Date created - 1997-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determinants of ammonia clearance by hemodialysis. AN - 78371317; 8828772 AB - Ammonia toxicity appears to contribute to the genesis of brain edema, a leading cause of death in fulminant hepatic failure. Because dialysis has been recommended for acute hyperammonemia in other conditions, we have conducted a study to analyze the determinants of ammonia clearance with the use of a single-pass dialyzer. We have used an ionic solution with a constant concentration of ammonia to estimate clearance at different blood flow rates, at dialysate flow rates, and with different dialyzer surfaces. Once hemodialysis had been optimized, we estimated ammonia, glutamine, and urea removal by using a single-compartment model. Our results show that the clearance of ammonia is blood flow dependent and is also influenced by dialysate flow rate and dialyzer surface. At clinically feasible conditions, ammonia can be extracted by more than 80% by setting the dialysate flow at a high rate. In addition to ammonia removal, hemodialysis allows the clearance of urea and glutamine, molecules that can be regarded as ammonia equivalents and that also undergo flow-dependent elimination. JF - Artificial organs AU - Cordoba, J AU - Blei, A T AU - Mujais, S AD - Department of Medicine, Lakeside Veterans Administration Medical Center, Chicago, IL 60611, USA. Y1 - 1996/07// PY - 1996 DA - July 1996 SP - 800 EP - 803 VL - 20 IS - 7 SN - 0160-564X, 0160-564X KW - Dialysis Solutions KW - 0 KW - Glutamine KW - 0RH81L854J KW - Ammonia KW - 7664-41-7 KW - Urea KW - 8W8T17847W KW - Index Medicus KW - Blood Flow Velocity -- physiology KW - Humans KW - In Vitro Techniques KW - Glutamine -- blood KW - Dialysis Solutions -- metabolism KW - Urea -- blood KW - Brain Edema -- therapy KW - Brain Edema -- metabolism KW - Ammonia -- blood KW - Brain Edema -- mortality KW - Hepatic Encephalopathy -- physiopathology KW - Hepatic Encephalopathy -- therapy KW - Renal Dialysis KW - Hepatic Encephalopathy -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78371317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Artificial+organs&rft.atitle=Determinants+of+ammonia+clearance+by+hemodialysis.&rft.au=Cordoba%2C+J%3BBlei%2C+A+T%3BMujais%2C+S&rft.aulast=Cordoba&rft.aufirst=J&rft.date=1996-07-01&rft.volume=20&rft.issue=7&rft.spage=800&rft.isbn=&rft.btitle=&rft.title=Artificial+organs&rft.issn=0160564X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-12 N1 - Date created - 1996-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Amphotericin B-associated hypertension. AN - 78357459; 8826557 AB - To report two cases of hypertension related to amphotericin B infusion. A 63-year-old woman with Candida albicans bacteremia and an 84-year-old man with Aspergillus fumigatus pneumonia developed hypertension within minutes of amphotericin B administration. Both patients' blood pressure returned to baseline soon after the infusion of amphotericin B was stopped. Neither patient was rechallenged. A causal relationship may exist between the administration of amphotericin B and these hypertensive episodes. Blood pressure in both patients normalized without treatment on discontinuation of the infusion. The mechanism of amphotericin B-associated hypertension is unclear but could include vasoconstricting properties of the drug or the administration of intravenous NaCl 0.9% prior to amphotericin B infusion. We recommend that intravenous NaCl 0.9% be administered following amphotericin B infusion and that the infusion be stopped if hypertensive episodes arise. Both acute hypertension and hypotension can occur in patients receiving amphotericin B for systemic fungal infections. JF - The Annals of pharmacotherapy AU - Le, Y AU - Rana, K Z AU - Dudley, M N AD - Department of Pharmacy, Veterans Administration Medical Center, Providence, RI, USA. PY - 1996 SP - 765 EP - 767 VL - 30 IS - 7-8 SN - 1060-0280, 1060-0280 KW - Antifungal Agents KW - 0 KW - Cephamycins KW - Itraconazole KW - 304NUG5GF4 KW - Sodium Chloride KW - 451W47IQ8X KW - Cefoxitin KW - 6OEV9DX57Y KW - Amphotericin B KW - 7XU7A7DROE KW - Index Medicus KW - Cephamycins -- administration & dosage KW - Cefoxitin -- administration & dosage KW - Humans KW - Aged KW - Pneumonia -- drug therapy KW - Itraconazole -- administration & dosage KW - Male KW - Female KW - Sodium Chloride -- pharmacology KW - Candidiasis -- drug therapy KW - Hypertension -- chemically induced KW - Antifungal Agents -- adverse effects KW - Aspergillus fumigatus KW - Aspergillosis -- drug therapy KW - Amphotericin B -- adverse effects KW - Antifungal Agents -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78357459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Amphotericin+B-associated+hypertension.&rft.au=Le%2C+Y%3BRana%2C+K+Z%3BDudley%2C+M+N&rft.aulast=Le&rft.aufirst=Y&rft.date=1996-07-01&rft.volume=30&rft.issue=7-8&rft.spage=765&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-13 N1 - Date created - 1996-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Both the 5' and 3' noncoding regions of the thyrotropin receptor messenger ribonucleic acid influence the level of receptor protein expression in transfected mamalian cells. AN - 78279460; 8770884 AB - The molecular basis for the difference in the bioresponsiveness of TSH receptor cell lines from two different laboratories has been investigated. We modified our 4-kb TSH receptor complementary DNA (cDNA) by deleting either the 5' untranslated region (UTR), the 3'UTR, or both UTRs. The 5'UTR contains two false AUG initiation codons followed by a stop codon. The cDNAs in the eukaryotic expression vector pSV2-NEO-ECE, as well as the 5'3'UTR-truncated cDNA in pSVL, were stably transfected into Chinese hamster ovary cells. Pools of more than 100 colonies were studied in order to minimize insertion site-dependent variation in the level of expression. Scatchard analysis of TSH binding indicated that the number of receptors on the surface of Chinese hamster ovary cells expressing the wild-type transcript (approximately 16,000/cell) increased approximately 2-fold with 5'UTR deletion, approximately 5-fold with 3'UTR deletion, and approximately 10-fold with both 5'UTR and 3'UTR deletion. TSH binding affinities of all constructs were in the range of 2-5 x 10(-10) M. No significant difference was evident between the 5'3'UTR truncated cDNAs in the two different vectors, pSV2-NEO-ECE and pSVL. The increase in the amplitude of the cAMP response to TSH stimulation was commensurate with the number of receptors expressed on the surface of the different cell lines. Truncation of the 5'UTR did not alter TSH receptor messenger RNA (mRNA) levels relative to the wild-type mRNA. In contrast, the level of the 3'UTR-truncated transcript, as well as the 5'3'UTR-deleted transcript, increased approximately 4-fold independent of the expression vector used. In summary, both the 5'UTR and 3'UTR of the human TSH receptor mRNA influence the level of receptor expression on transfected mammalian cells. In particular, the 3'UTR has a destabilizing influence on the MRNA. These data explain the greater level of TSH receptor expression in cell lines that are transfected with cDNA lacking these regions of the mRNA transcript. JF - Endocrinology AU - Kakinuma, A AU - Chazenbalk, G AU - Filetti, S AU - McLachlan, S M AU - Rapoport, B AD - Thyroid Molecular Biology Unit, Veterans' Administration Medical Center, San Francisco, California 94121, USA. Y1 - 1996/07// PY - 1996 DA - July 1996 SP - 2664 EP - 2669 VL - 137 IS - 7 SN - 0013-7227, 0013-7227 KW - Codon KW - 0 KW - DNA Primers KW - RNA, Messenger KW - Receptors, Thyrotropin KW - Recombinant Proteins KW - Thyrotropin KW - 9002-71-5 KW - Cyclic AMP KW - E0399OZS9N KW - Abridged Index Medicus KW - Index Medicus KW - Protein Biosynthesis KW - Animals KW - Recombinant Proteins -- biosynthesis KW - Humans KW - Mutagenesis, Site-Directed KW - Polymerase Chain Reaction KW - Base Sequence KW - Transfection KW - Recombinant Proteins -- metabolism KW - Kinetics KW - Cyclic AMP -- metabolism KW - Molecular Sequence Data KW - Point Mutation KW - CHO Cells KW - Sequence Deletion KW - Cricetinae KW - Receptors, Thyrotropin -- metabolism KW - Thyrotropin -- pharmacology KW - Receptors, Thyrotropin -- biosynthesis KW - RNA, Messenger -- metabolism KW - RNA, Messenger -- chemistry KW - Thyrotropin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78279460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Both+the+5%27+and+3%27+noncoding+regions+of+the+thyrotropin+receptor+messenger+ribonucleic+acid+influence+the+level+of+receptor+protein+expression+in+transfected+mamalian+cells.&rft.au=Kakinuma%2C+A%3BChazenbalk%2C+G%3BFiletti%2C+S%3BMcLachlan%2C+S+M%3BRapoport%2C+B&rft.aulast=Kakinuma&rft.aufirst=A&rft.date=1996-07-01&rft.volume=137&rft.issue=7&rft.spage=2664&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-10-10 N1 - Date created - 1996-10-10 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - S82807; GENBANK N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Case reports: trimethoprim-sulfamethoxazole-induced meningitis in patients with HIV infection. AN - 78208459; 8686726 AB - Meningitis is a frequent complication of the human immunodeficiency infection. Possible causes include bacterial, fungal, mycobacterial, syphilitic, and vital pathogens (including the human immunodeficiency virus). Drugs must also be considered in the differential diagnosis. Two patients with probable trimethoprim-sulfamethoxazole-induced meningitis are described in the setting of human immunodeficiency virus infection. JF - The American journal of the medical sciences AU - Jurado, R AU - Carpenter, S L AU - Rimland, D AD - Department of Medicine, Atlanta Veterans Administration Medical Center, Decatur, Georgia 30033, USA. Y1 - 1996/07// PY - 1996 DA - July 1996 SP - 27 EP - 29 VL - 312 IS - 1 SN - 0002-9629, 0002-9629 KW - Anti-Infective Agents KW - 0 KW - Trimethoprim, Sulfamethoxazole Drug Combination KW - 8064-90-2 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS/HIV KW - Pneumonia, Pneumocystis -- prevention & control KW - Humans KW - Adult KW - Male KW - Meningitis, Aseptic -- chemically induced KW - Anti-Infective Agents -- adverse effects KW - HIV Infections -- complications KW - Trimethoprim, Sulfamethoxazole Drug Combination -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78208459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Case+reports%3A+trimethoprim-sulfamethoxazole-induced+meningitis+in+patients+with+HIV+infection.&rft.au=Jurado%2C+R%3BCarpenter%2C+S+L%3BRimland%2C+D&rft.aulast=Jurado&rft.aufirst=R&rft.date=1996-07-01&rft.volume=312&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-08-20 N1 - Date created - 1996-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment Costs and Use of Community Mental Health Services for Schizophrenia by Age Cohorts AN - 61428612; 9705335 AB - The types of mental health services (MHSs) used & their costs for several age-defined cohorts of schizophrenia patients in a large community MHS are examined. The data covered all adult patients in the San Diego County, CA, mental health billing information system in 1986 & 1990. Community MHS use & codes were modeled as a function of patient demographic characteristics, diagnosis, & age. The costs for schizophrenia were higher than for other psychiatric disorders, & were also age dependent -- higher for the youngest & oldest cohorts. The economic burden of late-life schizophrenia to the public MHS is at least as high as that of schizophrenia in younger adults. 3 Tables, 1 Figure, 38 References. Adapted from the source document. JF - The American Journal of Psychiatry AU - Cuffel, Brian J AU - Jeste, Dilip V AU - Halpain, Maureen AU - Pratt, Carter AU - Tarke, Henry AU - Patterson, Thomas L AD - c/o Jeste -- Psychiatry Service 116A-1 San Diego Veterans Administration Medical Center, 3550 La Jolla Village Dr CA 92161 Y1 - 1996/07// PY - 1996 DA - July 1996 SP - 870 EP - 876 VL - 153 IS - 7 SN - 0002-953X, 0002-953X KW - schizophrenia, mental health services costs, age-defined cohorts KW - 1986/1990 billing data KW - San Diego County, California KW - Schizophrenia KW - San Diego, California KW - Mental Health Services KW - Age Differences KW - Health Care Utilization KW - Health Care Costs KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61428612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Treatment+Costs+and+Use+of+Community+Mental+Health+Services+for+Schizophrenia+by+Age+Cohorts&rft.au=Cuffel%2C+Brian+J%3BJeste%2C+Dilip+V%3BHalpain%2C+Maureen%3BPratt%2C+Carter%3BTarke%2C+Henry%3BPatterson%2C+Thomas+L&rft.aulast=Cuffel&rft.aufirst=Brian&rft.date=1996-07-01&rft.volume=153&rft.issue=7&rft.spage=870&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Schizophrenia; Mental Health Services; Health Care Costs; Health Care Utilization; San Diego, California; Age Differences ER - TY - JOUR T1 - Acoustic Characteristics of Less-Masculine-Sounding Male Speech AN - 85528116; 200204357 AB - This study compared samples of less-masculine-sounding (LMS) & more-masculine-sounding (MMS) male speech to identify acoustic characteristics, other than fundamental frequency, that might contribute to the perception of these categories. In the first phase, audiorecorded speech samples provided by 35 males were presented to 35 female listeners in a paired-comparison perceptual experiment. Nineteen of the male speech samples were judged reliably to fall within the LMS or MMS categories. Within those 19 samples, 8 speakers (4 LMS & 4 MMS) exhibited similar distributions of habitual fundamental frequency values in connected speech & in sustained phonation. In the second phase of the experiment, various acoustic measures of these 8 connected speech samples were conducted. Significant differences between measures of fundamental frequency contours, vowel formant midpoint values, & in the first, third & fourth spectral moments of two fricatives were revealed. These findings may be useful in creating stylized synthetic speech that varies on the dimension of masculinity, & they may have clinical relevance for patients wishing to modify the perception of masculinity invoked by their speech. Adapted from the source document JF - The Journal of the Acoustical Society of America AU - Avery, Jack D AU - Liss, Julie M AD - Speech Pathology Section, Veterans Administration Medical Center, Minneapolis, MN Y1 - 1996/06// PY - 1996 DA - June 1996 SP - 3738 EP - 3748 VL - 99 IS - 6 SN - 0001-4966, 0001-4966 KW - Social Perception (79950) KW - Speech Synthesis (82900) KW - Speech Perception (82700) KW - Formants (25300) KW - Acoustic Phonetics (00150) KW - Males (50830) KW - Language Styles (43930) KW - Voice Quality (95200) KW - Fundamental Frequency (26600) KW - article KW - 4017: psycholinguistics; psychoacoustics KW - 6110: phonetics; phonetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85528116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Acoustic+Characteristics+of+Less-Masculine-Sounding+Male+Speech&rft.au=Avery%2C+Jack+D%3BLiss%2C+Julie+M&rft.aulast=Avery&rft.aufirst=Jack&rft.date=1996-06-01&rft.volume=99&rft.issue=6&rft.spage=3738&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JASMAN N1 - SubjectsTermNotLitGenreText - Voice Quality (95200); Males (50830); Acoustic Phonetics (00150); Language Styles (43930); Fundamental Frequency (26600); Formants (25300); Speech Synthesis (82900); Speech Perception (82700); Social Perception (79950) ER - TY - JOUR T1 - Methods of managing levodopa-induced dyskinesias. AN - 78373696; 8828014 AB - Levodopa-induced dyskinesias result in considerable functional impairment for patients and formidable therapeutic challenges for physicians. A practical method of treating such dyskinesias is first to classify the levodopa dyskinesias according to their temporal profile after drug administration, namely, into predictable (interdose, biphasic and 'off-period') and unpredictable ('on-off') dyskinesias. Treatment of each type of dyskinesia requires a different and relatively specific therapeutic strategy. With progression of Parkinson's disease, the threshold for interdose dyskinesia lowers, while the threshold for antiparkinsonian efficacy is unchanged; therefore, the strategy is to maintain levodopa concentrations between these 2 thresholds and avoid high concentrations. Frequent small doses of liquid levodopa preparations may be indicated. Clozapine appears to increase the threshold for dyskinesia. However, its usefulness is limited primarily by dose-related sedation and by dose-unrelated agranulocytosis. Buspirone and fluoxetine may have specific antidyskinetic benefit. Surgical treatment may aid selected patients, although criteria for selection are not fully established. The biphasic dyskinesias occur just before and just after an oral dose of levodopa. They result when levodopa concentrations fall below or rise above the threshold for therapeutic efficacy; therefore, the strategy is to maintain concentrations as nearly constant as possible above that threshold. Dopamine agonists such as subcutaneous apomorphine combined with domperidone may be particularly helpful. Thalamic stimulation can also benefit selected patients. 'Off-period' dyskinesias occur at times of predicted low concentrations of levodopa. The treatment strategy is to provide sufficient levodopa or dopaminergic stimulation during those intervals. Dopamine agonists (e.g. bromocriptine at night) may help the characteristic early foot dystonia. Anticholinergic agents may also help. The unpredictable ('on-off') dyskinesias are first analysed to establish a pattern of response. Then, on the basis of that pattern, they are treated by maintaining levodopa concentrations or dopaminergic tone during the periods that would ordinarily be 'off.' Administration of liquid levodopa preparations, addition of dopaminergic agents, restriction of treatment during the morning hours as well as restriction of the majority of dietary protein in the evening meal may provide a period of predictable good function early in the day. Clozapine, even early in treatment, appears to reduce the incidence of these dyskinesias. Rescue with apomorphine during a malignant prolonged 'off' phase is particularly valuable. JF - Drug safety AU - Giron, L T AU - Koller, W C AD - Neurology Service, Department of Veterans Affairs Medical Center, Kansas City, Missouri, USA. GIRON.LOUIS_T+@KANSAS-CITY.VA.GOV Y1 - 1996/06// PY - 1996 DA - June 1996 SP - 365 EP - 374 VL - 14 IS - 6 SN - 0114-5916, 0114-5916 KW - Antiparkinson Agents KW - 0 KW - Levodopa KW - 46627O600J KW - Index Medicus KW - Humans KW - Dyskinesia, Drug-Induced -- therapy KW - Antiparkinson Agents -- adverse effects KW - Dyskinesia, Drug-Induced -- physiopathology KW - Levodopa -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78373696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=Methods+of+managing+levodopa-induced+dyskinesias.&rft.au=Giron%2C+L+T%3BKoller%2C+W+C&rft.aulast=Giron&rft.aufirst=L&rft.date=1996-06-01&rft.volume=14&rft.issue=6&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=01145916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-16 N1 - Date created - 1996-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemical synthesis, structural analysis, and decomposition of N-nitroso bile acid conjugates. AN - 78359271; 8818239 AB - N-nitrosoamides of 7 beta-hydroxylated bile acid conjugates, particularly of the ursodeoxycholic acid family have been synthesized. The products and synthetic intermediates were fully characterized by the results of high-resolution 1H NMR, FT-IR, FABMS and ESI-MS studies. The compounds, N-nitrosoglycoursodeoxycholic acid (NOGUDCA), N-nitrosoglycoursocholic acid (NOGUCA) and N-nitrosoglycodeoxycholic acid (NOGDCA) decomposed between pH 6 and 9 in aqueous buffer solutions, indicating a t1/2 of 5-7 h while N-nitrosotauroursodeoxycholic acid (NOTUDCA) indicated a much longer t1/2 of 15-17 h. These results suggest that the compounds are relatively stable and may enter the enterohepatic circulation. Their decomposition is similar to that of other N-nitrosamides, which generate alkylating agents and thereby act as DNA mutagens. JF - Bioorganic & medicinal chemistry AU - Dayal, B AU - Bhojawala, J AU - Rapole, K R AU - Pramanik, B N AU - Ertel, N H AU - Shefer, S AU - Salen, G AD - Medical Service, Veterans Administration Medical Center, East Orange, NJ 07019, USA. Y1 - 1996/06// PY - 1996 DA - June 1996 SP - 885 EP - 890 VL - 4 IS - 6 SN - 0968-0896, 0968-0896 KW - Bile Acids and Salts KW - 0 KW - Nitroso Compounds KW - Deoxycholic Acid KW - 005990WHZZ KW - Index Medicus KW - Half-Life KW - Spectrometry, Mass, Fast Atom Bombardment KW - Magnetic Resonance Spectroscopy KW - Nitroso Compounds -- chemistry KW - Deoxycholic Acid -- chemical synthesis KW - Bile Acids and Salts -- chemistry KW - Deoxycholic Acid -- analogs & derivatives KW - Bile Acids and Salts -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78359271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry&rft.atitle=Chemical+synthesis%2C+structural+analysis%2C+and+decomposition+of+N-nitroso+bile+acid+conjugates.&rft.au=Dayal%2C+B%3BBhojawala%2C+J%3BRapole%2C+K+R%3BPramanik%2C+B+N%3BErtel%2C+N+H%3BShefer%2C+S%3BSalen%2C+G&rft.aulast=Dayal&rft.aufirst=B&rft.date=1996-06-01&rft.volume=4&rft.issue=6&rft.spage=885&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry&rft.issn=09680896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-02-12 N1 - Date created - 1997-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Monitoring theophylline therapy to prevent toxicity. AN - 78273872; 8725203 JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Lubischer, A V AU - Lucas, L M AD - Pharmacy Service, Veterans Affairs Medical Center (VAMC), Portland, OR 97207, USA. lubischer.anne_v@portland.va.gov Y1 - 1996/06/01/ PY - 1996 DA - 1996 Jun 01 SP - 1292 EP - 1294 VL - 53 IS - 11 SN - 1079-2082, 1079-2082 KW - Theophylline KW - C137DTR5RG KW - Index Medicus KW - Oregon KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Drug Utilization KW - Education, Medical, Continuing KW - Lung Diseases, Obstructive -- drug therapy KW - Hospitals, Veterans KW - Theophylline -- adverse effects KW - Pharmacy Service, Hospital -- organization & administration KW - Iatrogenic Disease -- prevention & control KW - Pharmacy and Therapeutics Committee KW - Theophylline -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78273872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Monitoring+theophylline+therapy+to+prevent+toxicity.&rft.au=Lubischer%2C+A+V%3BLucas%2C+L+M&rft.aulast=Lubischer&rft.aufirst=A&rft.date=1996-06-01&rft.volume=53&rft.issue=11&rft.spage=1292&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-03-21 N1 - Date created - 1997-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of prostaglandins on deoxyribonucleic acid and aggrecan synthesis in the RCJ 3.1C5.18 chondrocyte cell line: role of second messengers. AN - 78029918; 8641167 AB - PGs play an important role in regulating articular chondrocyte function in both normal and pathological states. However, the mechanisms of the effects of PG on chondrocyte function remain undefined. We, therefore, examined the effects of PGE1, PGE2, and PGE2 alpha on second messenger generation in relation to DNA and aggrecan synthesis in the nontransformed rat RCJ 3.1C5.18 (RCJ) chondrocyte cell line. RCJ cells were grown under minimal attachment conditions on a composite collagen-agarose (0.15%/0.8%) gel to maintain a differentiated phenotype. PGE1 and PGE2 (0.001-100 microM) produced a similar dose-related increase in cAMP accumulation, with a maximal 8-fold increase over basal values, whereas PGF2 alpha produced a minimal 1.3-fold increase in cAMP levels only at 100 microM. On the other hand, both PGE2 and PGE2 alpha raised the intracellular free calcium ([Ca2+]i) concentration, derived primarily from extracellular sources, whereas PGE1 was without effect on [Ca2+]i. These three PGs also had divergent effects on DNA synthesis, as measured by [3H]thymidine ([3H]TdR) incorporation. PGF2 alpha (0.001-5 microM) produced a dose-related increase in [3H]TdR incorporation, with a maximal 1.6-fold increase over baseline values at 5 microM and a slight decline to below maximal levels at 10 microM. PGE2 exhibited a contrasting inverse biphasic response, with an initial small suppressive effect that was maximal at 0.1 microM and a secondary stimulatory phase producing a small increase over control values at 5 microM. PGE1 had a uniformly suppressive effect, producing a 30% decrease at 10 microM. Despite the divergent effects of PGE1, PGE2, and PGE2 alpha on second messenger generation and DNA synthesis, all three PGs produced a dose-related stimulation of aggrecan synthesis. PGF2 alpha was the most potent, producing significant stimulation at 0.001 microM and a maximal 104% increase at 5 microM. PGE1 and PGE2 were approximately equipotent and approximately 60% as effective as PGF2 alpha in stimulating aggrecan synthesis. Northern analysis demonstrated that the effects of PG on aggrecan synthesis were not accompanied by changes in aggrecan core protein steady state messenger RNA levels. Thus, the effects of PG on aggrecan production in RCJ cells appear to be regulated at the posttranscriptional level. Forskolin and (Bu)2cAMP mimicked the suppressive effects of PGE1 on [3H]TdR incorporation, as well as the stimulatory effect of PGE1 on aggrecan synthesis. In addition, the phorbol ester 12-O-tetradecanoyl phorbol acetate mimicked PGF2 alpha stimulation of [3H]TdR incorporation and aggrecan synthesis, and the effects of PGE2 alpha on these processes were blocked by protein kinase C inhibitors. Therefore, it appears that in mammalian chondrocytes, PGE1 primarily activates the cAMP-protein kinase A second messenger system, PGE2 alpha affects primarily the Ca2(+)-protein kinase C system, and PGE2 activates both pathways. Moreover, PG posttranscriptional regulation of aggrecan synthesis in chondrocytes involves both the cAMP-protein kinase A and Ca2(+)-protein kinase C second messenger systems. JF - Endocrinology AU - Lowe, G N AU - Fu, Y H AU - McDougall, S AU - Polendo, R AU - Williams, A AU - Benya, P D AU - Hahn, T J AD - Department of Medicine, West Los Angeles Veterans Administration Medical Center, California 90073, USA. Y1 - 1996/06// PY - 1996 DA - June 1996 SP - 2208 EP - 2216 VL - 137 IS - 6 SN - 0013-7227, 0013-7227 KW - Agc1 protein, rat KW - 0 KW - Aggrecans KW - Extracellular Matrix Proteins KW - Lectins, C-Type KW - Prostaglandins KW - Proteoglycans KW - Colforsin KW - 1F7A44V6OU KW - Bucladesine KW - 63X7MBT2LQ KW - DNA KW - 9007-49-2 KW - Dinoprost KW - B7IN85G1HY KW - Cyclic AMP KW - E0399OZS9N KW - Protein Kinase C KW - EC 2.7.11.13 KW - Alprostadil KW - F5TD010360 KW - Dinoprostone KW - K7Q1JQR04M KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Abridged Index Medicus KW - Index Medicus KW - Alprostadil -- pharmacology KW - Animals KW - Dinoprostone -- pharmacology KW - Dinoprost -- pharmacology KW - Bucladesine -- pharmacology KW - Rats KW - Calcium -- metabolism KW - Protein Kinase C -- metabolism KW - Colforsin -- pharmacology KW - Cyclic AMP -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Line KW - Second Messenger Systems KW - Proteoglycans -- biosynthesis KW - Cartilage -- metabolism KW - Prostaglandins -- pharmacology KW - DNA -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78029918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Effects+of+prostaglandins+on+deoxyribonucleic+acid+and+aggrecan+synthesis+in+the+RCJ+3.1C5.18+chondrocyte+cell+line%3A+role+of+second+messengers.&rft.au=Lowe%2C+G+N%3BFu%2C+Y+H%3BMcDougall%2C+S%3BPolendo%2C+R%3BWilliams%2C+A%3BBenya%2C+P+D%3BHahn%2C+T+J&rft.aulast=Lowe&rft.aufirst=G&rft.date=1996-06-01&rft.volume=137&rft.issue=6&rft.spage=2208&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-07-18 N1 - Date created - 1996-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of high affinity epidermal growth factor binding in the aorta of Dahl hypertensive rats fed with high salt diet. AN - 77926032; 10968197 AB - Dahl salt sensitive rats (DS) developed severe hypertension on four weeks of high salt feeding while the Dahl salt resistant rats (DR) remained normotensive under the same conditions. The specific maximal binding of epidermal growth factor (EGF) in the freshly prepared kidney membranes of high salt fed DS rats was higher than those from DR rats (5.3 +/- 1.9 vs. 1.6 +/- 0.62 fmoles/mg protein, p<0.001). Scatchard analysis of EGF binding in the kidney showed one class of receptors in the DR (K(d) = 0.75 +/- 0.05 nM) as well as in the DS rats (K(d)=0.69 +/- 0.06 nM). The EGF binding in the aortic membranes of DS rats was also high compared to DR rats (24.98 +/- 5.52 vs. 13.20 +/- 4.10 fmoles/mg protein, p < 0.001). Scatchard analysis of EGF binding in the aorta showed one class of receptors in the DR aorta with a K(d) of 0.70 +/- 0.06 nM. On the other hand, in the DS rat aorta two classes of receptors, a high affinity form (K(d)=0.05 +/- 0.01 nM) and a low affinity form (K(d)=3.5 +/- 0.3 nM) were noted. The induction of a high affinity species of EGF receptors in the aorta, appears to be a mechanism unique to the salt fed DS rats. JF - Hypertension research : official journal of the Japanese Society of Hypertension AU - Swaminathan, N AU - Sambhi, M P AD - Department of Medicine Veterans Administration Medical Center & UCLA School of Medicine, CA, USA. Y1 - 1996/06// PY - 1996 DA - June 1996 SP - 65 EP - 68 VL - 19 IS - 2 SN - 0916-9636, 0916-9636 KW - RNA, Messenger KW - 0 KW - Sodium Chloride, Dietary KW - Epidermal Growth Factor KW - 62229-50-9 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Kidney -- metabolism KW - Receptor, Epidermal Growth Factor -- metabolism KW - Rats, Inbred Dahl KW - Protein Processing, Post-Translational -- physiology KW - RNA, Messenger -- analysis KW - Myocardium -- metabolism KW - Rats KW - Protein Binding -- physiology KW - Receptor, Epidermal Growth Factor -- genetics KW - Kinetics KW - Protein Binding -- drug effects KW - Blood Pressure -- drug effects KW - Gene Expression -- physiology KW - Male KW - Aorta -- metabolism KW - Hypertension -- chemically induced KW - Sodium Chloride, Dietary -- pharmacology KW - Epidermal Growth Factor -- pharmacology KW - Epidermal Growth Factor -- metabolism KW - Hypertension -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77926032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+research+%3A+official+journal+of+the+Japanese+Society+of+Hypertension&rft.atitle=Induction+of+high+affinity+epidermal+growth+factor+binding+in+the+aorta+of+Dahl+hypertensive+rats+fed+with+high+salt+diet.&rft.au=Swaminathan%2C+N%3BSambhi%2C+M+P&rft.aulast=Swaminathan&rft.aufirst=N&rft.date=1996-06-01&rft.volume=19&rft.issue=2&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Hypertension+research+%3A+official+journal+of+the+Japanese+Society+of+Hypertension&rft.issn=09169636&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-09-21 N1 - Date created - 2000-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Attention and regional cerebral blood flow in posttraumatic stress disorder patients with substance abuse histories. AN - 78338533; 8797239 AB - Performance on an attentional task was assessed in posttraumatic stress disorder patients with substance abuse histories (PTSD-SA). Positron emission tomography (PET) was used to measure concurrent regional cerebral blood flow (rCBF). Eight male PTSD-SA patients and eight normal subjects each received three serial PET scans with 15O-labeled water under the following conditions: (1) resting, (2) auditory continuous performance task (ACPT1), and (3) repeat auditory task (ACPT2). PTSD-SA patients made more errors of commission on the ACPT than normal subjects. Examination of right frontal and parietal cortex ACPT task substrates revealed decreased parietal blood flow in PTSD-SA, which may represent a pathophysiology for poor attentional task performance in PTSD-SA. Attentional problems may underlie other symptomatology in PTSD. JF - Psychiatry research AU - Semple, W E AU - Goyer, P F AU - McCormick, R AU - Compton-Toth, B AU - Morris, E AU - Donovan, B AU - Muswick, G AU - Nelson, D AU - Garnett, M L AU - Sharkoff, J AU - Leisure, G AU - Miraldi, F AU - Schulz, S C AD - Cleveland Veterans Administration Medical Center (11B), Brecksville, OH 44141, USA. Y1 - 1996/05/31/ PY - 1996 DA - 1996 May 31 SP - 17 EP - 28 VL - 67 IS - 1 SN - 0165-1781, 0165-1781 KW - Index Medicus KW - Humans KW - Adult KW - Tomography, Emission-Computed KW - Task Performance and Analysis KW - Middle Aged KW - Male KW - Functional Laterality KW - Auditory Perception KW - Prefrontal Cortex -- diagnostic imaging KW - Cognition -- physiology KW - Stress Disorders, Post-Traumatic -- complications KW - Parietal Lobe -- diagnostic imaging KW - Prefrontal Cortex -- physiology KW - Prefrontal Cortex -- blood supply KW - Substance-Related Disorders -- complications KW - Parietal Lobe -- blood supply KW - Regional Blood Flow KW - Parietal Lobe -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78338533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Attention+and+regional+cerebral+blood+flow+in+posttraumatic+stress+disorder+patients+with+substance+abuse+histories.&rft.au=Semple%2C+W+E%3BGoyer%2C+P+F%3BMcCormick%2C+R%3BCompton-Toth%2C+B%3BMorris%2C+E%3BDonovan%2C+B%3BMuswick%2C+G%3BNelson%2C+D%3BGarnett%2C+M+L%3BSharkoff%2C+J%3BLeisure%2C+G%3BMiraldi%2C+F%3BSchulz%2C+S+C&rft.aulast=Semple&rft.aufirst=W&rft.date=1996-05-31&rft.volume=67&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-11-22 N1 - Date created - 1996-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Semantic Processing and Orthographic Specificity in Hemispatial Neglect AN - 85619190; 9700135 AB - Priming from lexical information was examined in two sets of experiments (total N = 10 patients diagnosed with unilateral right hemisphere infarction exhibiting contralesional hemispatial neglect, aged 64-76, & 20 normal controls, aged 59-73) consisting of priming & discrimination tasks on lexical targets presented to the left (LVF) or right visual field (RVF) following semantically or orthographically related primes. Results indicated that although patients were unable to discriminate words presented in LVF (performance was at chance level for all tasks), priming was significantly higher when LVF primes were followed by semantically related (vs unrelated) targets; significant negative priming occurred for targets preceded by LVF primes that were orthographically similar to a semantically related word. It is concluded that semantic processing of neglected lexical information is based on fully specified perceptual & orthographic information, & a lateral inhibitory mechanism is proposed to account for negative priming that maximizes the probability that neglected primes will reach awareness, though the retrieval mechanism ultimately fails. 5 Tables, 2 Figures, 22 References. Adapted from the source document JF - Journal of Cognitive Neuroscience AU - McGlinchey-Berroth, Regina AU - Milberg, William P AU - Verfaellie, Mieke AU - Grande, Laura AU - D'Esposito, Mark AU - Alexander, Michael AD - GRECC Veterans Administration Medical Center, 1400 VFW Parkway West Roxbury MA 02132 Y1 - 1996/05// PY - 1996 DA - May 1996 SP - 291 EP - 304 VL - 8 IS - 3 SN - 0898-929X, 0898-929X KW - visual word discrimination, semantic priming effect KW - experiments KW - right-hemisphere-damaged adults aged 64-76 KW - Elderly (21350) KW - Brain Damage (09400) KW - Letter Recognition (46400) KW - Familiarity (23800) KW - Word Recognition (98200) KW - Semantic Processing (76760) KW - article KW - 4018: psycholinguistics; neurolinguistics KW - 4014: psycholinguistics; semantic processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85619190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cognitive+Neuroscience&rft.atitle=Semantic+Processing+and+Orthographic+Specificity+in+Hemispatial+Neglect&rft.au=McGlinchey-Berroth%2C+Regina%3BMilberg%2C+William+P%3BVerfaellie%2C+Mieke%3BGrande%2C+Laura%3BD%27Esposito%2C+Mark%3BAlexander%2C+Michael&rft.aulast=McGlinchey-Berroth&rft.aufirst=Regina&rft.date=1996-05-01&rft.volume=8&rft.issue=3&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cognitive+Neuroscience&rft.issn=0898929X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCONEO N1 - SubjectsTermNotLitGenreText - Semantic Processing (76760); Word Recognition (98200); Letter Recognition (46400); Brain Damage (09400); Familiarity (23800); Elderly (21350) ER - TY - JOUR T1 - Short segment Barrett's esophagus: clinical and histological features, associated endoscopic findings, and association with gastric intestinal metaplasia. AN - 85231188; pmid-8633592 AB - OBJECTIVES: To prospectively determine the clinical features, associated esophageal endoscopic lesions, associated gastric intestinal metaplasia, and prevalence of dysplasia and adenocarcinoma of short segment Barrett's. METHODS: All patients undergoing upper endoscopy over a 5-month period were scrutinized for endoscopic features suggestive of short segment Barrett's, and, if present, multiple biopsies were obtained from the suspicious areas. Prevalence of gastric intestinal metaplasia was determined by obtaining biopsies from the antrum, body, and cardia. RESULTS: Two hundred thirty seven patients were examined. Short segment Barrett's was suspected in only 42 patients, and traditional Barrett's was noted in 45 patients. Short segment Barrett's was confirmed by biopsy in 48%. Clinical presentation of short segment Barrett's was that of typical or complicated gastroesophageal reflux disease in 53%. A hiatal hernia was the most common associated esophageal endoscopic finding; however, none of the endoscopic findings differed significantly from findings of patients who did not have short segment Barrett's. Diagnosis of short segment Barrett's required histological analysis. A significant difference was noted in the prevalence of intestinal metaplasia between the esophagus and stomach in patients with Barrett's. No dysplasia or adenocarcinoma was detected in patients with short segment Barrett's. CONCLUSIONS: Short segment Barrett's is a frequent finding in patients undergoing upper endoscopy. All patients with short tongues or patches of red mucosa lying less than 2 cm above the esophagogastric junction should be biopsied to exclude short segment Barrett's. Large scale endoscopic and histological surveillance studies along with long-term follow-up are required to clarify short segment Barrett's prevalence and cancer risk. JF - The American Journal of Gastroenterology AU - Weston, A P AU - Krmpotich, P AU - Makdisi, W F AU - Cherian, R AU - Dixon, A AU - McGregor, D H AU - Banerjee, S K AD - Veterans Administration Medical Center, Kansas City, Missouri, USA. PY - 1996 SP - 981 EP - 986 VL - 91 IS - 5 SN - 0002-9270, 0002-9270 KW - Esophageal Neoplasms KW - Human KW - Aged KW - Prospective Studies KW - Intestines KW - Metaplasia KW - Adult KW - Middle Age KW - Barrett Esophagus KW - Adenocarcinoma KW - Male KW - Stomach KW - Female KW - Gastroscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85231188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Short+segment+Barrett%27s+esophagus%3A+clinical+and+histological+features%2C+associated+endoscopic+findings%2C+and+association+with+gastric+intestinal+metaplasia.&rft.au=Weston%2C+A+P%3BKrmpotich%2C+P%3BMakdisi%2C+W+F%3BCherian%2C+R%3BDixon%2C+A%3BMcGregor%2C+D+H%3BBanerjee%2C+S+K&rft.aulast=Weston&rft.aufirst=A&rft.date=1996-05-01&rft.volume=91&rft.issue=5&rft.spage=981&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Effect of clozapine on motor function in schizophrenic patients. AN - 78306061; 8794509 AB - It is well established that clozapine is less likely than typical antipsychotic drugs to cause clinically discernible extrapyramidal side-effects. There is a paucity of data, however, on clozapine's motor effects. In this report we compare normal controls to groups of chronic schizophrenic patients treated with either typical antipsychotic drugs or with clozapine. Motor function was measured with a target-matching task, a test relying on submaximal sustained force control. Results indicated that patients on clozapine performed with significantly lower accuracy (greater variability) of force control. Even though the clozapine patients were treatment resistant to typical antipsychotic drugs, and many had a history of tardive dyskinesia, we postulate that the observed deficit is likely due to clozapine treatment rather than to earlier treatments or other factors. The observed force control deficit may be the result of an increase in myoclonus and a generally lower level of overall motor activity. JF - Schizophrenia research AU - Vrtunski, P B AU - Konicki, P E AU - Kwon, K Y AU - Jurjus, G AU - Jaskiw, G E AU - Jaskiw, G J AD - Cleveland VA Medical Center, Brecksville, OH 44141, USA. vrtunski.bart@cleveland.va.gov Y1 - 1996/05// PY - 1996 DA - May 1996 SP - 187 EP - 198 VL - 20 IS - 1-2 SN - 0920-9964, 0920-9964 KW - Antipsychotic Agents KW - 0 KW - Clozapine KW - J60AR2IKIC KW - Index Medicus KW - Kinesthesis -- drug effects KW - Humans KW - Adult KW - Neurologic Examination -- drug effects KW - Infant, Newborn KW - Middle Aged KW - Male KW - Antipsychotic Agents -- administration & dosage KW - Clozapine -- administration & dosage KW - Psychomotor Performance -- drug effects KW - Schizophrenia -- diagnosis KW - Hand Strength KW - Schizophrenic Psychology KW - Schizophrenia -- drug therapy KW - Clozapine -- adverse effects KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78306061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+research&rft.atitle=Effect+of+clozapine+on+motor+function+in+schizophrenic+patients.&rft.au=Vrtunski%2C+P+B%3BKonicki%2C+P+E%3BKwon%2C+K+Y%3BJurjus%2C+G%3BJaskiw%2C+G+E%3BJaskiw%2C+G+J&rft.aulast=Vrtunski&rft.aufirst=P&rft.date=1996-05-01&rft.volume=20&rft.issue=1-2&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+research&rft.issn=09209964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-05 N1 - Date created - 1996-12-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Schizophr Res 1996 Dec 15;22(3):269 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of glutamate antagonists on methamphetamine and 3,4-methylenedioxymethamphetamine-induced striatal dopamine release in vivo. AN - 78283649; 8780022 AB - Several amphetamine analogues are reported to increase striatal glutamate efflux in vivo, whereas other data indicate that glutamate is capable of stimulating the efflux of dopamine (DA) in the striatum via a glutamate receptor-dependent mechanism. Based on these findings, it has been proposed that the ability of glutamate receptor-blocking drugs to antagonize the effects of amphetamine may be explained by their capacity to inhibit DA release induced by glutamate. To examine this possibility further, we investigated in vivo the ability of glutamate antagonists to inhibit DA release induced by either methamphetamine (METH) or 3,4-methylenedioxymethamphetamine (MDMA). Both METH and MDMA increased DA efflux in the rat striatum and, in animals killed 1 week later, induced persistent depletions of DA and serotonin in tissue. Pretreatment with MK-801 or CGS 19755 blocked the neurotoxic effects of METH and MDMA but did not significantly alter striatal DA efflux induced by either stimulant. Infusion of 6-cyano-7-nitro-quinoxaline-2,3-dione into the striatum likewise did not alter METH-induced DA overflow, and none of the glutamatergic antagonists affected the basal release of DA when given alone. The findings suggest that the neuroprotective effects of NMDA antagonists do not involve an inhibition of DA release, nor do the data support the proposal that glutamate tonically stimulates striatal DA efflux in vivo. Whether phasic increases in glutamate content might stimulate DA release, however, remains to be determined. JF - Journal of neurochemistry AU - Finnegan, K T AU - Taraska, T AD - Psychiatry Service, Veterans Administration Medical Center, Salt Lake City, Utah 84148, USA. Y1 - 1996/05// PY - 1996 DA - May 1996 SP - 1949 EP - 1958 VL - 66 IS - 5 SN - 0022-3042, 0022-3042 KW - Amines KW - 0 KW - Excitatory Amino Acid Antagonists KW - Pipecolic Acids KW - Methamphetamine KW - 44RAL3456C KW - selfotel KW - 4VGJ4A41L2 KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - 6-Cyano-7-nitroquinoxaline-2,3-dione KW - 6OTE87SCCW KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Pipecolic Acids -- pharmacology KW - 6-Cyano-7-nitroquinoxaline-2,3-dione -- pharmacology KW - Amines -- antagonists & inhibitors KW - Male KW - Dizocilpine Maleate -- pharmacology KW - Corpus Striatum -- metabolism KW - Methamphetamine -- pharmacology KW - Dopamine -- metabolism KW - N-Methyl-3,4-methylenedioxyamphetamine -- pharmacology KW - Excitatory Amino Acid Antagonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78283649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Effects+of+glutamate+antagonists+on+methamphetamine+and+3%2C4-methylenedioxymethamphetamine-induced+striatal+dopamine+release+in+vivo.&rft.au=Finnegan%2C+K+T%3BTaraska%2C+T&rft.aulast=Finnegan&rft.aufirst=K&rft.date=1996-05-01&rft.volume=66&rft.issue=5&rft.spage=1949&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-01-14 N1 - Date created - 1997-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical prediction rules to optimize cytotoxin testing for Clostridium difficile in hospitalized patients with diarrhea. AN - 78066276; 8644759 AB - Although routine testing of hospitalized patients with diarrhea for Clostridium difficile cytotoxin has been advocated as a high-yield procedure, the rationale for this practice has been questioned. To target a low-yield subgroup for whom routine testing could be deferred, we derived a clinical decision rule for predicting results of the C difficile cytotoxin assay in hospitalized adults with diarrhea. We hypothesized a priori that two variables, antibiotic use (within 30 days prior to testing) and history of significant diarrhea (new onset of > 3 partially formed or watery stools per 24 hour period), would be highly predictive of cytotoxin results, and obtained these data on 480 consecutive patients who underwent diagnostic testing for C difficile at a university hospital and affiliated Veterans Affairs medical center. For more detailed modelling, we recorded symptoms, signs, comorbidity, and other potential causes of diarrhea for 68 test positive patients (cases) and 265 randomly selected test negative patients (controls) within the study cohort. The overall prevalence of positive cytotoxin assays was 14%. Prior antibiotic therapy (OR = 9.0, 95% CI 2.1-38.4), significant diarrhea (OR = 2.2, 95% CI 1.1-4.7), and abdominal pain (OR = 1.9, 95% CI 0.96-3.7) were independent predictors of cytotoxin assay results. The model discriminated patients with positive and negative assays with a receiver operating characteristic (ROC) area of 0.68; observed and predicted probabilities of a positive cytotoxin assay were well correlated over the entire range of observed probabilities (r2 = 0.86). A decision rule (defined as positive if prior antibiotic use and either significant diarrhea or abdominal pain are present) demonstrated sensitivity and specificity of 86 and 45%. When applied to the entire dataset (N = 480), a simplified a priori rule, defined as positive if both prior antibiotic use and history of significant diarrhea are present, demonstrated sensitivity, specificity, positive and negative predictive value of 80, 45, 18 and 94%, respectively (6% of those predicted to be cytotoxin-negative actually tested positive). Use of this rule would have averted 39% of cytotoxin assays in our study population. Patients without prior antibiotic use and either significant diarrhea or abdominal pain are unlikely to have positive C difficile cytotoxin assay results, and may not routinely require cytotoxin testing. JF - The American journal of medicine AU - Katz, D A AU - Lynch, M E AU - Littenberg, B AD - Department of Medicine, White River Junction Veterans Administration Medical Center, Lebanon, New Hampshire, USA. Y1 - 1996/05// PY - 1996 DA - May 1996 SP - 487 EP - 495 VL - 100 IS - 5 SN - 0002-9343, 0002-9343 KW - Anti-Bacterial Agents KW - 0 KW - Cytotoxins KW - Abridged Index Medicus KW - Index Medicus KW - Sensitivity and Specificity KW - Feces -- microbiology KW - Probability KW - Anti-Bacterial Agents -- therapeutic use KW - Odds Ratio KW - Abdominal Pain -- etiology KW - Humans KW - Anti-Bacterial Agents -- adverse effects KW - Prognosis KW - Aged KW - Hospitalization KW - Cells, Cultured KW - Adult KW - Neutralization Tests KW - Data Interpretation, Statistical KW - Middle Aged KW - Adolescent KW - Time Factors KW - Male KW - Female KW - Enterocolitis, Pseudomembranous -- diagnosis KW - Clostridium difficile -- isolation & purification KW - Clostridium difficile -- metabolism KW - Clostridium Infections -- diagnosis KW - Diarrhea -- etiology KW - Diarrhea -- diagnosis KW - Cytotoxins -- biosynthesis KW - Enterocolitis, Pseudomembranous -- chemically induced KW - Cytotoxins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78066276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+medicine&rft.atitle=Clinical+prediction+rules+to+optimize+cytotoxin+testing+for+Clostridium+difficile+in+hospitalized+patients+with+diarrhea.&rft.au=Katz%2C+D+A%3BLynch%2C+M+E%3BLittenberg%2C+B&rft.aulast=Katz&rft.aufirst=D&rft.date=1996-05-01&rft.volume=100&rft.issue=5&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+medicine&rft.issn=00029343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-07-15 N1 - Date created - 1996-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cost-effective models for flutamide for prostate carcinoma patients: are they helpful to policy makers? AN - 78025428; 8646685 AB - More than 50,000 male patients received hormonal therapy for metastatic prostate carcinoma in 1995. Nonsteroidal antiandrogens, such as flutamide, when used in conjunction with castration, are effective in prolonging the time to progression of disease and survival. Only one-third of newly diagnosed patients with metastatic prostate carcinoma receive flutamide. Physicians may be reluctant to prescribe flutamide because of quality of life, toxicity, and cost considerations. Physician focus groups evaluated quality of life factors for metastatic prostate cancer. Using quality of life estimates with the National Cancer Institute's (NCI) 0036 clinical trial results, our revised model of flutamide use predicted that, for minimal disease, survival increased by 4.33 quality adjusted months (QAMs) at an incremental cost of $25,000 per quality adjusted life year (QALY) saved and for severe disease, survival increased by 4.11 QAM at a cost of $18,000 per QALY saved. However, if quality of life estimates are used in conjunction with the Prostate Cancer Trialists' Collaborative Group (PCTCG) meta-analysis estimates, survival increased by 2.1 QAM at an incremental cost of $41,000 per QALY saved for persons with severe disease and increased by 2.6 QAM at an incremental cost of $53,700 per QALY saved for persons with minimal disease. Using NCI 0036 trial data, flutamide has an incremental cost-effectiveness more favorable than most therapies, while estimates based on the PCTCG found a less favorable outcome for the drug. Concerns about out-of-pocket expenditures and efficacy limit flutamide utilization; quality of life considerations are less cogent. JF - Cancer AU - Bennett, C L AU - Matchar, D AU - McCrory, D AU - McLeod, D G AU - Crawford, E D AU - Hillner, B E AD - Lakeside Veterans Administration Medical Center, Chicago, Illinois 60601, USA. Y1 - 1996/05/01/ PY - 1996 DA - 1996 May 01 SP - 1854 EP - 1861 VL - 77 IS - 9 SN - 0008-543X, 0008-543X KW - Androgen Antagonists KW - 0 KW - Antineoplastic Agents, Hormonal KW - Flutamide KW - 76W6J0943E KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Multicenter Studies as Topic KW - Policy Making KW - Humans KW - Disease Progression KW - Quality of Life KW - Value of Life KW - Health Care Costs KW - Orchiectomy KW - Focus Groups KW - Survival Rate KW - Cost-Benefit Analysis KW - National Institutes of Health (U.S.) KW - Treatment Outcome KW - Meta-Analysis as Topic KW - Male KW - Carcinoma -- secondary KW - Androgen Antagonists -- therapeutic use KW - Prostatic Neoplasms -- drug therapy KW - Models, Economic KW - Androgen Antagonists -- economics KW - Androgen Antagonists -- adverse effects KW - Flutamide -- economics KW - Carcinoma -- drug therapy KW - Flutamide -- therapeutic use KW - Antineoplastic Agents, Hormonal -- economics KW - Flutamide -- adverse effects KW - Antineoplastic Agents, Hormonal -- adverse effects KW - Antineoplastic Agents, Hormonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78025428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Cost-effective+models+for+flutamide+for+prostate+carcinoma+patients%3A+are+they+helpful+to+policy+makers%3F&rft.au=Bennett%2C+C+L%3BMatchar%2C+D%3BMcCrory%2C+D%3BMcLeod%2C+D+G%3BCrawford%2C+E+D%3BHillner%2C+B+E&rft.aulast=Bennett&rft.aufirst=C&rft.date=1996-05-01&rft.volume=77&rft.issue=9&rft.spage=1854&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-07-22 N1 - Date created - 1996-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabolic Abnormalities in Offspring of NIDDM Patients with a Family History of Diabetes Mellitus AN - 1815693068; PQ0002414638 AB - NIDDM appears to be an inherited condition. Our aim was to identify early metabolic abnormalities in non-diabetic offspring with one NIDDM parent and with a strongly positive (n=58, age 27.8 plus or minus 7.0 years) or a negative family history (n=38, age 27.4 plus or minus 6.7 years) of diabetes. These were compared with 31 offspring of non-diabetic parents (age 26.9 plus or minus 5.5 years). After an overnight fast, blood was taken for glucose, insulin, C-peptide, insulin receptors, and lipids. All the subjects underwent a 75g oral glucose tolerance test. The positive family history group had significantly higher fasting levels of triglycerides (1.09 plus or minus 0.24 vs control subjects: CS: 0.93 plus or minus 0.16mmoll super(-1), p<0.001), insulin (102.8 plus or minus 46.4 vs CS: 77.5 plus or minus 32.4 pmoll super(-1), p<0.01) and C-peptide (0.69 plus or minus 0.22 vs CS: 0.61 plus or minus 0.19nmoll super(-1), p<0.05) and lower numbers of insulin receptors per red cell (9.110 super(3) (4.5-18.1, 95% confidence intervals) vs CS: (11.210 super(3) (6.3-19.9)), p<0.01, despite similar blood glucose levels. After a glucose challenge (120min), the increases in both insulin and C-peptide concentrations were significantly greater in the positive family history group (289.2 plus or minus 214.1 pmoll super(-1), 2.23 plus or minus 1.48nmoll super(-1)), respectively, than in CS (192.4 plus or minus 170.3pmoll super(-1), p<0.05) (1.54 plus or minus 0.99nmoll super(-1) p<0.01), respectively. No significant differences were found in fasting and post-challenge glucose levels. The negative family history group had significantly lower numbers of insulin receptors 9.410 super(3) (4.1-15.2) compared with CS (p<0.05). Insulin sensitivity was significantly reduced in the positive family history group (41.6%) compared with control subjects (51.9%), p<0.01. The results strongly support the familial basis of the disease. JF - Diabetic Medicine AU - Migdalis, IN AU - Zachariadis, D AU - Kalogeropoulou, K AU - Nounopoulos, C AU - Bouloukos, A AU - Samartzis, M AD - Department of Diabetes and Medicine, NIMTS Veterans Administration Hospital, Athens, Greece. Y1 - 1996/05// PY - 1996 DA - May 1996 SP - 434 EP - 440 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 13 IS - 5 SN - 0742-3071, 0742-3071 KW - Toxicology Abstracts KW - Diabetes mellitus KW - Blood KW - Age KW - Lipids KW - Triglycerides KW - Glucose tolerance KW - Progeny KW - Fasting KW - Insulin receptors KW - Insulin KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815693068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetic+Medicine&rft.atitle=Metabolic+Abnormalities+in+Offspring+of+NIDDM+Patients+with+a+Family+History+of+Diabetes+Mellitus&rft.au=Migdalis%2C+IN%3BZachariadis%2C+D%3BKalogeropoulou%2C+K%3BNounopoulos%2C+C%3BBouloukos%2C+A%3BSamartzis%2C+M&rft.aulast=Migdalis&rft.aufirst=IN&rft.date=1996-05-01&rft.volume=13&rft.issue=5&rft.spage=434&rft.isbn=&rft.btitle=&rft.title=Diabetic+Medicine&rft.issn=07423071&rft_id=info:doi/10.1002%2F%28SICI%291096-9136%28199605%2913%3A53.0.CO%3B2-R LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Blood; Age; Triglycerides; Lipids; Glucose tolerance; Progeny; Fasting; Insulin receptors; Insulin DO - http://dx.doi.org/10.1002/(SICI)1096-9136(199605)13:5<434::AID-DIA102>3.0.CO;2-R ER - TY - JOUR T1 - Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase. AN - 78012819; 8621627 AB - Human neutrophil microbicidal activity is largely mediated by reactive species generated by the oxygen-dependent myeloperoxidase (MPO) system. Peroxidase-negative neutrophils from many patients with hereditary MPO deficiency possess a 90-kDa MPO-related protein. We recently identified a missense mutation, R569W, in the MPO gene of many subjects with MPO deficiency. In these studies we examined the consequences of R569W on MPO biosynthesis and processing, using stably transfected K562 cells expressing normal MPO or the R569W mutation. K562 cells expressing normal MPO mimicked faithfully many features of MPO biosynthesis in myeloid cells. 1) apopro-MPO was synthesized; 2) a functional heme group was inserted into apopro-MPO, and enzymatically active pro-MPO was thereby generated; 3) pro-MPO underwent proteolytic processing to mature MPO; and 4) hemin augmented the processing of pro-MPO. pREP-R569W cells synthesized apopro-MPO, but heme was not inserted. Neither enzymatically active pro-MPO nor mature MPO was synthesized by transfectants expressing mutated cDNA, confirming our hypothesis that the R569W mutation results in a form of apopro-MPO which does not undergo post-translational processing to enzymatically active MPO species. In addition, these data support previous suggestions that heme insertion into apopro-MPO is necessary for its subsequent proteolytic processing into mature MPO subunits. JF - The Journal of biological chemistry AU - Nauseef, W M AU - Cogley, M AU - McCormick, S AD - Department of Medicine, Veterans Administration Medical Center, Iowa City, Iowa 52242, USA. Y1 - 1996/04/19/ PY - 1996 DA - 1996 Apr 19 SP - 9546 EP - 9549 VL - 271 IS - 16 SN - 0021-9258, 0021-9258 KW - DNA Primers KW - 0 KW - DNA, Complementary KW - Recombinant Proteins KW - Heme KW - 42VZT0U6YR KW - Peroxidase KW - EC 1.11.1.7 KW - Index Medicus KW - Recombinant Proteins -- biosynthesis KW - Blood Bactericidal Activity KW - Humans KW - Protein Processing, Post-Translational KW - Heme -- pharmacology KW - Amino Acid Sequence KW - Mutagenesis, Site-Directed KW - Polymerase Chain Reaction KW - Base Sequence KW - Leukemia, Erythroblastic, Acute KW - Transfection KW - Recombinant Proteins -- metabolism KW - Molecular Sequence Data KW - Cell Line KW - Peroxidase -- genetics KW - Peroxidase -- metabolism KW - Point Mutation KW - Neutrophils -- enzymology KW - Neutrophils -- physiology KW - Peroxidase -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78012819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Effect+of+the+R569W+missense+mutation+on+the+biosynthesis+of+myeloperoxidase.&rft.au=Nauseef%2C+W+M%3BCogley%2C+M%3BMcCormick%2C+S&rft.aulast=Nauseef&rft.aufirst=W&rft.date=1996-04-19&rft.volume=271&rft.issue=16&rft.spage=9546&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-06-18 N1 - Date created - 1996-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Translational initiation factor eIF-4E. A link between cardiac load and protein synthesis. AN - 78030730; 8626533 AB - To define the coupling mechanism between cardiac load and the rate of protein synthesis, changes in the extent of eIF-4E phosphorylation were measured after imposition of a load. Electrically stimulated contraction of adult feline cardiocytes increased eIF-4E phosphorylation to 34% after 4 h, as compared with 8% phosphorylation in quiescent controls. However, eIF-4E phosphorylation did not increase upon electrical stimulation in the presence of 7.5 mM 2,3-butanedione monoxime, an inhibitor of actin-myosin cross-bridge cycling and active tension development. Treatment of adult cardiocytes with either 0.1 microM insulin or 0.1 microM phorbol 12-myristate 13-acetate increased eIF-4E phosphorylation to 23 and 64%, respectively, but these increases were not blocked by 2,3-butanedione monoxime. In canine models of acute hemodynamic overload in vivo, eIF-4E phosphorylation increased to 23% in response to left ventricular pressure overload as compared with 7% phosphorylation in controls. Acute volume overload had no effect on eIF-4E phosphorylation. These changes in eIF-4E phosphorylation account for differences in anabolic responses to acute pressure versus acute volume overload. These data suggest that eIF-4E phosphorylation is a mechanism by which increased cardiac load is coupled to accelerated rates of protein synthesis. JF - The Journal of biological chemistry AU - Wada, H AU - Ivester, C T AU - Carabello, B A AU - Cooper, G AU - McDermott, P J AD - Department of Medicine, Gazes Cardiac Research Institute and Veterans Administration Medical Center, Charleston, South Carolina 29401-5799, USA. Y1 - 1996/04/05/ PY - 1996 DA - 1996 Apr 05 SP - 8359 EP - 8364 VL - 271 IS - 14 SN - 0021-9258, 0021-9258 KW - Eukaryotic Initiation Factor-4E KW - 0 KW - Insulin KW - Muscle Proteins KW - Peptide Initiation Factors KW - Phosphoproteins KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Space life sciences KW - Protein Biosynthesis KW - Animals KW - Blood Pressure KW - Humans KW - Insulin -- pharmacology KW - Electric Stimulation KW - Phosphorylation KW - Myocardial Contraction KW - Stress, Mechanical KW - Cats KW - Dogs KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Stroke Volume KW - Cardiomegaly -- metabolism KW - Phosphoproteins -- metabolism KW - Peptide Initiation Factors -- metabolism KW - Heart -- physiology KW - Myocardium -- metabolism KW - Muscle Proteins -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78030730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Translational+initiation+factor+eIF-4E.+A+link+between+cardiac+load+and+protein+synthesis.&rft.au=Wada%2C+H%3BIvester%2C+C+T%3BCarabello%2C+B+A%3BCooper%2C+G%3BMcDermott%2C+P+J&rft.aulast=Wada&rft.aufirst=H&rft.date=1996-04-05&rft.volume=271&rft.issue=14&rft.spage=8359&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-06-21 N1 - Date created - 1996-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adenomatous polyposis coli presenting as adenocarcinoma of the appendix. AN - 85233422; pmid-8677956 JF - The American Journal of Gastroenterology AU - Parker, G M AU - Stollman, N H AU - Rogers, A AD - Department of Medicine, Division of Gastroenterology, Veterans Administration Hospital, University of Miami School of Medicine, Florida 33125, USA. PY - 1996 SP - 801 EP - 802 VL - 91 IS - 4 SN - 0002-9270, 0002-9270 KW - Appendectomy KW - Colonoscopy KW - Adenomatous Polyposis Coli KW - Human KW - Neoplasms, Multiple Primary KW - Appendix KW - Middle Age KW - Case Report KW - Adenocarcinoma KW - Appendiceal Neoplasms KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85233422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Adenomatous+polyposis+coli+presenting+as+adenocarcinoma+of+the+appendix.&rft.au=Parker%2C+G+M%3BStollman%2C+N+H%3BRogers%2C+A&rft.aulast=Parker&rft.aufirst=G&rft.date=1996-04-01&rft.volume=91&rft.issue=4&rft.spage=801&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - ICI 204,636, an atypical antipsychotic: efficacy and safety in a multicenter, placebo-controlled trial in patients with schizophrenia. U.S. SEROQUEL Study Group. AN - 78124896; 8690831 AB - ICI 204,636 is a new, potentially atypical antipsychotic. In early phase II trials, the antipsychotic was well tolerated and results suggested efficacy in the treatment of the positive and negative symptoms of schizophrenia. The efficacy and safety of ICI 204,636 were evaluated on a larger scale in a 6-week, multicenter, double-blind trial. Hospitalized patients who met DSM-III-R criteria for chronic or subchronic schizophrenia with acute exacerbation, as well as other criteria, were randomized to ICI 204,636 (75 to 750 mg daily) (N = 54) or placebo (N = 55). Patients were assessed weekly by use of the Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Negative Symptoms (SANS), and Clinical Global Impression Scale (CGI) for efficacy and the Simpson Scale and Abnormal Involuntary Movement Scale for extrapyramidal side effects (EPS). Significant differences (p < or = 0.05) between treatment groups, which favored ICI 204,636, were identified throughout the trial. Endpoint differences were significant (by analysis of covariance) for BPRS factor IV (activation) and SANS scores and were marginally significant for total BPRS, BPRS factor III (thought disturbance), BPRS positive-symptom cluster, and CGI Severity of Illness item scores (p = 0.07, 0.09, 0.06, and 0.09, respectively). ICI 204,636 was well tolerated, although it was associated with mild transient increases in alanine aminotransferase and a higher incidence of somnolence and anticholinergic effects compared with placebo. In the dose range studied, treatment with ICI 204,636 did not induce EPS as determined by analysis of Simpson Scale total scores and lack of treatment-emergent acute dystonic reactions. Furthermore, ICI 204,636 did not produce sustained levels of prolactin; the mean change from baseline at endpoint (-7.2 micrograms/L) was comparable (p = 0.44) to that for placebo (-8.2 micrograms/L). These findings distinguish ICI 204,636 from standard antipsychotics and confirm preclinical predictions that ICI 204,636 is an atypical antipsychotic. JF - Journal of clinical psychopharmacology AU - Borison, R L AU - Arvanitis, L A AU - Miller, B G AD - Psychiatry Service, Augusta Veterans Administration Medical Center, GA 30910, USA. Y1 - 1996/04// PY - 1996 DA - April 1996 SP - 158 EP - 169 VL - 16 IS - 2 SN - 0271-0749, 0271-0749 KW - Antipsychotic Agents KW - 0 KW - Dibenzothiazepines KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Index Medicus KW - Acute Disease KW - Psychiatric Status Rating Scales KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Dibenzothiazepines -- adverse effects KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenic Psychology KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects KW - Dibenzothiazepines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78124896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=ICI+204%2C636%2C+an+atypical+antipsychotic%3A+efficacy+and+safety+in+a+multicenter%2C+placebo-controlled+trial+in+patients+with+schizophrenia.+U.S.+SEROQUEL+Study+Group.&rft.au=Borison%2C+R+L%3BArvanitis%2C+L+A%3BMiller%2C+B+G&rft.aulast=Borison&rft.aufirst=R&rft.date=1996-04-01&rft.volume=16&rft.issue=2&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-08-29 N1 - Date created - 1996-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Physiological origins and functional correlates of EEG rhythmic activities: implications for self-regulation. AN - 78383982; 8833314 AB - Recent neurophysiological findings in relation to thalamocortical mechanisms for sensory processing, together with established anatomical and expanding functional evidence, have provided a rational theoretical framework for the interpretation of normal and abnormal EEG rhythmic activities. This perspective is integrated here with earlier animal studies which were the foundation for many current applications of EEG self-regulation as a clinical tool. Basic evidence concerning the origins, frequency modulation, and functional significance of normal EEG rhythmic activities is reviewed here in an effort to provide guiding principles for the interpretation of clinical abnormalities and their remediation with EEG feedback training. JF - Biofeedback and self-regulation AU - Sterman, M B AD - Veterans Administration Medical Center, Sepulveda, CA 91343, USA. Y1 - 1996/03// PY - 1996 DA - March 1996 SP - 3 EP - 33 VL - 21 IS - 1 SN - 0363-3586, 0363-3586 KW - Index Medicus KW - Substance-Related Disorders -- physiopathology KW - Animals KW - Epilepsy -- physiopathology KW - Biofeedback, Psychology -- physiology KW - Humans KW - Psychomotor Performance -- physiology KW - Attention Deficit Disorder with Hyperactivity -- physiopathology KW - Cognition -- physiology KW - Thalamus -- physiology KW - Conditioning, Operant -- physiology KW - Electroencephalography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78383982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biofeedback+and+self-regulation&rft.atitle=Physiological+origins+and+functional+correlates+of+EEG+rhythmic+activities%3A+implications+for+self-regulation.&rft.au=Sterman%2C+M+B&rft.aulast=Sterman&rft.aufirst=M&rft.date=1996-03-01&rft.volume=21&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Biofeedback+and+self-regulation&rft.issn=03633586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-05-22 N1 - Date created - 1997-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The quest for the autoantibody immunodominant region on thyroid peroxidase: guided mutagenesis based on a hypothetical three-dimensional model. AN - 77972434; 8603566 AB - Thyroid peroxidase (TPO), a cell surface glycoprotein, is the major autoantigen in autoimmune thyroiditis in humans. The molecular cloning and expression of Ig genes from thyroid-infiltrating B cells has generated a large repertoire of human TPO Fab that have been used to map an immunodominant region on TPO. However, the topological site of this region, consisting of a cluster of highly conformational epitopes, remains unknown. Using the recently elucidated three-dimensional structure of myeloperoxidase as a model, we stably expressed on the surface of eukaryotic cells eight "guided" mutants of the TPO molecule. The sites of these mutations were strategically located to alter the surface contour of the molecule with minimal disruption to its core structure. Remarkably, in the present study (in contrast to previous unguided TPO mutagenesis studies), all eight TPO mutants retained recognition by the TPO Fab. These results support the validity of the model used for mutagenesis. Although not identifying the immunodominant region on TPO in thyroid autoimmunity, our data provide evidence against the involvement of certain topological segments and may help to narrow the search for this region. The most open region remaining as a candidate location is the antero-inferior portion of the molecule. JF - Endocrinology AU - Nishikawa, T AU - Rapoport, B AU - McLachlan, S M AD - Thyroid Molecular Biology Unit, Veterans Administration Medical Center, San Francisco, California 94121, USA. Y1 - 1996/03// PY - 1996 DA - March 1996 SP - 1000 EP - 1006 VL - 137 IS - 3 SN - 0013-7227, 0013-7227 KW - Autoantibodies KW - 0 KW - Immunodominant Epitopes KW - Iodide Peroxidase KW - EC 1.11.1.8 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Base Sequence KW - Thyroid Gland -- pathology KW - Models, Molecular KW - Humans KW - Molecular Sequence Data KW - Thyroid Gland -- enzymology KW - CHO Cells KW - Amino Acid Sequence KW - Mutagenesis KW - Cricetinae KW - Iodide Peroxidase -- immunology KW - Iodide Peroxidase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77972434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=The+quest+for+the+autoantibody+immunodominant+region+on+thyroid+peroxidase%3A+guided+mutagenesis+based+on+a+hypothetical+three-dimensional+model.&rft.au=Nishikawa%2C+T%3BRapoport%2C+B%3BMcLachlan%2C+S+M&rft.aulast=Nishikawa&rft.aufirst=T&rft.date=1996-03-01&rft.volume=137&rft.issue=3&rft.spage=1000&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-05-14 N1 - Date created - 1996-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Social Support Networks of Confidants to People with AIDS AN - 61562259; 199601836 AB - AIDS (acquired immune deficiency syndrome) has a devastating impact on the social support networks of those most closely involved with the person with AIDS (PWA). Here, the social support networks of confidants to PWAs are reported, based on the findings of intensive, semistructured interviews. Numerous changes were observed in the confidants' supportive resources, network structure, & functioning. Implications for social work practice are discussed. 21 References. Adapted from the source document. JF - Social Work AU - Jankowski, Stephen AU - Videka-Sherman, Lynn AU - Laquidara-Dickinson, Karen AD - Mental Health Clinic Stratton Veterans' Administration Medical Center, 113 Holland Ave Albany NY 12208 Y1 - 1996/03// PY - 1996 DA - March 1996 SP - 206 EP - 213 VL - 41 IS - 2 SN - 0037-8046, 0037-8046 KW - social support networks, confidants of persons with acquired immune deficiency syndrome KW - interviews KW - Friendship KW - Caregivers KW - Support Networks KW - Acquired Immune Deficiency Syndrome KW - Social Support KW - article KW - 6126: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61562259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work&rft.atitle=Social+Support+Networks+of+Confidants+to+People+with+AIDS&rft.au=Jankowski%2C+Stephen%3BVideka-Sherman%2C+Lynn%3BLaquidara-Dickinson%2C+Karen&rft.aulast=Jankowski&rft.aufirst=Stephen&rft.date=1996-03-01&rft.volume=41&rft.issue=2&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Social+Work&rft.issn=00378046&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Social Support; Support Networks; Acquired Immune Deficiency Syndrome; Caregivers; Friendship ER - TY - JOUR T1 - Phonological Processing and the Role of Strategy in Silent Reading: Behavioral and Electrophysiological Evidence AN - 85618161; 9604921 AB - The role of phonological processing in silent reading was examined. Undergraduates (N = 51, aged 19-29) performed semantic relatedness tasks on word pairs (homophonically, orthographically, or semantically related, or unrelated) & sentence acceptability judgement tasks on sentences with homophones (congruent or incongruent with the target word along the parameters of the semantic relatedness tasks). Results of analyses of variance on behavioral (reaction times & error rates) & electrophysiological (event related potentials indexed via electroencephalograph at negative polarity peaks between poststimulus latencies of 200 & 400 msecs) measures are discussed: (1) Both measures suggest semantic judgments made during silent reading utilize phonological information. (2) Electrophysiological data evidences differentiation of semantic processes from orthographic & phonological processes. (3) Behavioral data demonstrate the use of phonological information to be dependent on the nature of the task & stimulus. (4) Stimulus-driven processes (orthographic & phonological) are found to dominate in early processing stages, strategy-driven processes (semantic) in later stages. 1 Table, 8 Figures, 76 References. S. Novak JF - Brain and Language AU - Niznikiewicz, Margaret AU - Squires, Nancy K AD - Veterans Administration Medical Center, 940 Belmont St Brockton MA 02401 Y1 - 1996/02// PY - 1996 DA - February 1996 SP - 342 EP - 364 VL - 52 IS - 2 SN - 0093-934X, 0093-934X KW - silent reading, phonological processing role KW - semantic relatedness /sentence acceptability judgment tasks, behavioral /electrophysiological measures KW - undergraduates aged 19-29 KW - Phonological Processing (65110) KW - Evoked Responses (23450) KW - Silent Reading (78800) KW - Orthography (61750) KW - Semantic Processing (76760) KW - Reading Processes (71150) KW - article KW - 4019: psycholinguistics; phonological processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85618161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+Language&rft.atitle=Phonological+Processing+and+the+Role+of+Strategy+in+Silent+Reading%3A+Behavioral+and+Electrophysiological+Evidence&rft.au=Niznikiewicz%2C+Margaret%3BSquires%2C+Nancy+K&rft.aulast=Niznikiewicz&rft.aufirst=Margaret&rft.date=1996-02-01&rft.volume=52&rft.issue=2&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=Brain+and+Language&rft.issn=0093934X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRLGAZ N1 - SubjectsTermNotLitGenreText - Evoked Responses (23450); Silent Reading (78800); Reading Processes (71150); Phonological Processing (65110); Semantic Processing (76760); Orthography (61750) ER - TY - JOUR T1 - Prostaglandin E2 induces Egr-1 mRNA in MC3T3-E1 osteoblastic cells by a protein kinase C-dependent pathway. AN - 78112590; 8848429 AB - Prostaglandin E2 (PGE2) plays an important role in the regulation of osteoblast metabolism. However, the nuclear signal transduction mechanisms involved in the actions of PGE2 have not been clearly defined. One mechanism may involve induction of immediate early genes such as the transcription factor Egr-1. In the present study, we examined the effects of PGE2 on induction of Egr-1 mRNA in MC3T3-E1 osteoblasts. Time course studies with 2 microM PGE2 showed maximal induction of Egr-1 mRNA at 30 min. In cells pretreated with cycloheximide (CHX), induction of Egr-1 mRNA reached a maximum at 60 min and remained elevated for at least 240 min. Preincubation with CHX was associated with superinduction of Egr-1. Inhibition of protein kinase C activity by pretreatment with 1 microM chelerythrine chloride or by prolonged stimulation with 50 ng/ml tetradecanoyl phorbol acetate (TPA) attenuated the induction of Egr-1 mRNA by 2 microM PGE2. These data indicate that in MC3T3-E1 cells, PGE2 increase Egr-1 mRNA levels via a protein kinase C-dependent pathway. JF - Prostaglandins, leukotrienes, and essential fatty acids AU - Fang, M A AU - Noguchi, G M AU - McDougall, S AD - Geriatric Research, Education and Clinical Center, Veterans Health Administration Medical Center, West Los Angeles, CA, USA. Y1 - 1996/02// PY - 1996 DA - February 1996 SP - 109 EP - 114 VL - 54 IS - 2 SN - 0952-3278, 0952-3278 KW - Alkaloids KW - 0 KW - Benzophenanthridines KW - DNA-Binding Proteins KW - Early Growth Response Protein 1 KW - Egr1 protein, mouse KW - Enzyme Inhibitors KW - Immediate-Early Proteins KW - Phenanthridines KW - RNA, Messenger KW - Transcription Factors KW - Cycloheximide KW - 98600C0908 KW - chelerythrine KW - E3B045W6X0 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Dinoprostone KW - K7Q1JQR04M KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Blotting, Northern KW - RNA, Messenger -- drug effects KW - Transcription, Genetic KW - Mice KW - Down-Regulation KW - RNA, Messenger -- metabolism KW - Cycloheximide -- pharmacology KW - Phenanthridines -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Protein Kinase C -- metabolism KW - Osteoblasts -- drug effects KW - Dinoprostone -- pharmacology KW - DNA-Binding Proteins -- biosynthesis KW - Transcription Factors -- biosynthesis KW - Protein Kinase C -- pharmacology KW - Bone and Bones -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78112590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prostaglandins%2C+leukotrienes%2C+and+essential+fatty+acids&rft.atitle=Prostaglandin+E2+induces+Egr-1+mRNA+in+MC3T3-E1+osteoblastic+cells+by+a+protein+kinase+C-dependent+pathway.&rft.au=Fang%2C+M+A%3BNoguchi%2C+G+M%3BMcDougall%2C+S&rft.aulast=Fang&rft.aufirst=M&rft.date=1996-02-01&rft.volume=54&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Prostaglandins%2C+leukotrienes%2C+and+essential+fatty+acids&rft.issn=09523278&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-10-23 N1 - Date created - 1996-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Noncompetitive NMDA channel blockade during waking intensely stimulates NREM delta. AN - 78050375; 8632344 AB - We previously found that subanesthetic doses of ketamine administered during the dark (active) period (DP) in rats strongly increased the integrated amplitude of the delta (1-4 Hz) electroencephalogram (EEG) in subsequent nonrapid eye movement (NREM) sleep. Here, we injected MK-801 into adult male Sprague-Dawley rats to test the hypothesis that such delta stimulation is characteristic of drugs that noncompetitively block the cation channel gated by the N-methyl-D-aspartate (NMDA) receptor. Injections of 0.3 and 0.5 mg/kg MK-801 in the middle of the DP produced waking intoxication for approximately 3 hr. In the following light period, NREM delta integrated amplitude was markedly increased in every rat (mean 55% increase after 0.5 mg/kg). A separate control experiment with 3-hr sleep deprivation in the mid-DP showed that the delta stimulation could not be attributed to sleep loss during MK-801 intoxication. Mechanisms by which NMDA cation channel blockade might stimulate NREM delta include a compensatory (homeostatic) sleep response to the metabolic, receptor or other neuronal effects of cation channel blockade; pathologic EEG slowing caused by neurotoxicity (in which case NREM delta might provide a noninvasive index of neurotoxic vacuolization); or a persistent, direct action of the drug or its metabolites on delta-generating systems. Questions of mechanism gain interest because of the magnitude of these pharmacologic effects on the sleep EEG component (delta) thought to be correlated with brain recuperative processes. In addition, our findings add to growing evidence implicating excitatory amino acid systems in sleep regulation. JF - The Journal of pharmacology and experimental therapeutics AU - Campbell, I G AU - Feinberg, I AD - Veterans Administration Northern California System of Clinics, Davis, USA. Y1 - 1996/02// PY - 1996 DA - February 1996 SP - 737 EP - 742 VL - 276 IS - 2 SN - 0022-3565, 0022-3565 KW - Excitatory Amino Acid Antagonists KW - 0 KW - Receptors, N-Methyl-D-Aspartate KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Wakefulness KW - Male KW - Sleep Stages -- physiology KW - Delta Rhythm -- drug effects KW - Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors KW - Excitatory Amino Acid Antagonists -- pharmacology KW - Dizocilpine Maleate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78050375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Noncompetitive+NMDA+channel+blockade+during+waking+intensely+stimulates+NREM+delta.&rft.au=Campbell%2C+I+G%3BFeinberg%2C+I&rft.aulast=Campbell&rft.aufirst=I&rft.date=1996-02-01&rft.volume=276&rft.issue=2&rft.spage=737&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-07-03 N1 - Date created - 1996-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cocaine concentration-effect relationship in the presence and absence of lidocaine: evidence of competitive binding between cocaine and lidocaine. AN - 78038728; 8632323 AB - To better understand the interaction between cocaine and lidocaine, we studied the cocaine's concentration-effect relationship for action potential duration (APD) and the rate of rise of phase 0 of the action potential (Vmax) of canine papillary muscle in the presence and absence of lidocaine. We measured APD and Vmax during programmed stimulation and superfusion with normal Tyrode's, 30 microM cocaine and 30 microM cocaine + 30 microM lidocaine. Using two microelectrodes, we simultaneously recorded action potentials from two sites during programmed stimulation and measured the conduction velocity and effective refractory period during exposure to normal Tyrode's, cocaine and cocaine + lidocaine. Cocaine with or without lidocaine delayed the plateau of the APD restitution curve. At 1000 msec cycle length, the addition of 30 microM lidocaine to the superfusate containing 30 microM cocaine shortened the time constant for reactivation of Vmax from 514 +/- 63 to 234 +/- 28 msec (P 100 microM, APD progressively shortened. The addition of lidocaine to the superfusate with cocaine > 100 microM tended to attenuate the progressive APD shortening due to cocaine. Lidocaine shifted the curve correlating cocaine concentration and reduction of Vmax rightward, but preserved Emax at cocaine concentration > 225 microM. These findings suggest competitive antagonism between cocaine and lidocaine at a single sodium channel receptor. lidocaine displaces cocaine from the sodium channel receptor through competitive binding. Lidocaine may prove to be beneficial in reversing cocaine-induced slowing of ventricular conduction. JF - The Journal of pharmacology and experimental therapeutics AU - Liu, D AU - Hariman, R J AU - Bauman, J L AD - Department of Medicine, Veterans Administration Hospital, Hines, Illinois, USA. Y1 - 1996/02// PY - 1996 DA - February 1996 SP - 568 EP - 577 VL - 276 IS - 2 SN - 0022-3565, 0022-3565 KW - Anesthetics, Local KW - 0 KW - Sodium Channels KW - Lidocaine KW - 98PI200987 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Drug Interactions KW - Refractory Period, Electrophysiological -- drug effects KW - Dose-Response Relationship, Drug KW - Action Potentials -- drug effects KW - Heart Conduction System -- drug effects KW - Binding, Competitive KW - In Vitro Techniques KW - Dogs KW - Papillary Muscles -- physiology KW - Papillary Muscles -- drug effects KW - Female KW - Male KW - Lidocaine -- metabolism KW - Anesthetics, Local -- pharmacology KW - Sodium Channels -- metabolism KW - Lidocaine -- pharmacology KW - Cocaine -- pharmacology KW - Cocaine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78038728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Cocaine+concentration-effect+relationship+in+the+presence+and+absence+of+lidocaine%3A+evidence+of+competitive+binding+between+cocaine+and+lidocaine.&rft.au=Liu%2C+D%3BHariman%2C+R+J%3BBauman%2C+J+L&rft.aulast=Liu&rft.aufirst=D&rft.date=1996-02-01&rft.volume=276&rft.issue=2&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-07-03 N1 - Date created - 1996-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aging impairs afferent nerve function in rat intestine. Reduction of mesenteric hyperemia induced by intraduodenal capsaicin and acid. AN - 77966062; 8601381 AB - The high incidence of peptic ulcer disease despite decreased acid secretion in the elderly suggests an impairment of mucosal defense mechanism with aging. Stimulation of the intestinal mucosal afferent nerves by intraduodenal application of capsaicin or hydrochloric acid (HCl) increases superior mesenteric artery (SMA) blood flow and protects the duodenal mucosa against deep damage. We tested the hypothesis that the intestinal hyperemia induced by intraduodenal capsaicin or HCL is significantly reduced in older (12 months) rats compared with younger (2 months) rats. Mesenteric blood flow was measured by pulsed Doppler flowmetry in anesthetized rats with the flow probe around the SMA. Two milliliters per kilogram of 160 microM capsaicin or 0.1 N HCl administered intraduodenally increased SMA blood flow significantly in both age groups. The peak response in SMA blood flow, however, was significantly smaller in the older rats than in the younger rats. These observations support the hypothesis that impairment of afferent nerve function occurs with aging in the rat intestine. JF - Digestive diseases and sciences AU - Seno, K AU - Lam, K AU - Leung, J W AU - Leung, F W AD - Research and Medical Services, Sepulveda Veterans Administration Medical Center, California 91343, USA. Y1 - 1996/02// PY - 1996 DA - February 1996 SP - 346 EP - 351 VL - 41 IS - 2 SN - 0163-2116, 0163-2116 KW - Hydrochloric Acid KW - QTT17582CB KW - Capsaicin KW - S07O44R1ZM KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Afferent Pathways -- physiology KW - Intestinal Mucosa -- drug effects KW - Male KW - Hydrochloric Acid -- administration & dosage KW - Aging -- physiology KW - Duodenum -- physiology KW - Duodenum -- drug effects KW - Duodenum -- innervation KW - Hyperemia -- chemically induced KW - Hydrochloric Acid -- pharmacology KW - Capsaicin -- administration & dosage KW - Hyperemia -- physiopathology KW - Mesenteric Artery, Superior -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77966062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Aging+impairs+afferent+nerve+function+in+rat+intestine.+Reduction+of+mesenteric+hyperemia+induced+by+intraduodenal+capsaicin+and+acid.&rft.au=Seno%2C+K%3BLam%2C+K%3BLeung%2C+J+W%3BLeung%2C+F+W&rft.aulast=Seno&rft.aufirst=K&rft.date=1996-02-01&rft.volume=41&rft.issue=2&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-05-07 N1 - Date created - 1996-05-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Dig Dis Sci. 1998 Dec;43(12):2771 [9881513] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Outcome of risperidone therapy in elderly patients with chronic psychosis. AN - 78630222; 8976471 AB - This report reviews the efficacy and tolerability of risperidone therapy in elderly patients with chronic psychosis. A computer search was conducted for all patients who were sixty-five years or older at the time of risperidone therapy at the Cleveland VAMC. Data collected included psychiatric diagnosis, risperidone dosage/side effects, concurrent medications, comorbid medical diagnosis, and response to treatment. Treatment response was quantified on a graduated scale. Twenty-six patients age sixty-five or older were included in this sample. Mean age of the group was 70.4 years. Mean risperidone dosage was 3.8 mg/day for a mean duration of 251 days. Eighteen of twenty-six patients (69%) had schizophrenia, two of twenty-six (8%) had schizoaffective disorder, two of twenty-six (8%) had bipolar disorder, and four of twenty-six (15%) had other psychotic disorders. Patients had a mean of 2.4 medical diagnoses in addition to their primary psychiatric diagnosis. Twenty-two of twenty-six patients (85%) had clinical improvement on risperidone, and twenty of twenty-six (77%) had improvement that was either marked or moderate. Risperidone therapy was very well tolerated in this elderly population with nineteen of twenty-six patients (73%) remaining on risperidone therapy at completion of this study. Medical illness did not appear to be worsened or complicated by risperidone therapy. Risperidone appears to be an effective and well tolerated antipsychotic for elderly patients with chronic psychosis. JF - International journal of psychiatry in medicine AU - Sajatovic, M AU - Ramirez, L F AU - Vernon, L AU - Brescan, D AU - Simon, M AU - Jurjus, G AD - Cleveland Veterans Administration Medical Center, USA. Y1 - 1996 PY - 1996 DA - 1996 SP - 309 EP - 317 VL - 26 IS - 3 SN - 0091-2174, 0091-2174 KW - Antipsychotic Agents KW - 0 KW - Risperidone KW - L6UH7ZF8HC KW - Index Medicus KW - Aged -- physiology KW - Aged, 80 and over KW - Humans KW - Retrospective Studies KW - Inpatients -- psychology KW - Chronic Disease KW - Male KW - Psychotic Disorders -- complications KW - Antipsychotic Agents -- administration & dosage KW - Antipsychotic Agents -- therapeutic use KW - Risperidone -- administration & dosage KW - Risperidone -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Risperidone -- therapeutic use KW - Psychotic Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78630222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+psychiatry+in+medicine&rft.atitle=Outcome+of+risperidone+therapy+in+elderly+patients+with+chronic+psychosis.&rft.au=Sajatovic%2C+M%3BRamirez%2C+L+F%3BVernon%2C+L%3BBrescan%2C+D%3BSimon%2C+M%3BJurjus%2C+G&rft.aulast=Sajatovic&rft.aufirst=M&rft.date=1996-01-01&rft.volume=26&rft.issue=3&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=International+journal+of+psychiatry+in+medicine&rft.issn=00912174&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-04-04 N1 - Date created - 1997-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characteristics of posttraumatic stress disorder-alcohol abuse comorbidity in women. AN - 78561327; 8934438 AB - Trauma characteristics and symptoms were examined in 12 women diagnosed with posttraumatic stress disorder (PTSD) and alcohol abuse (AA), 13 women with PTSD only, and 22 controls. Participants served during the Vietnam era. Women completed diagnostic interviews and a questionnaire battery. Results showed that PTSD-AA women reported more childhood sexual abuse and sexual victimization during wartime service than the other two groups. Groups did not differ on other childhood trauma variables, nor on adult physical assault and traditional wartime stressor exposure. PTSD-AA women reported more PTSD, dissociation, and borderline personality traits than the other two groups. These results suggest that trauma type, specifically sexual victimization across the life span, is an important factor in dual diagnosis in women, and that women with PTSD-AA have a particularly severe level of symptoms relative to women with only PTSD and controls. JF - Journal of substance abuse AU - Ouimette, P C AU - Wolfe, J AU - Chrestman, K R AD - Boston VA Medical Center/Tufts University School of Medicine, USA. Ouimette.Paige_J@Palo-Alto.va.gov Y1 - 1996 PY - 1996 DA - 1996 SP - 335 EP - 346 VL - 8 IS - 3 SN - 0899-3289, 0899-3289 KW - Index Medicus KW - Rape -- psychology KW - Humans KW - Child KW - Personality Inventory KW - Combat Disorders -- epidemiology KW - Comorbidity KW - Vietnam KW - Child Abuse, Sexual -- psychology KW - Combat Disorders -- psychology KW - Risk Factors KW - Adult KW - Combat Disorders -- diagnosis KW - Middle Aged KW - Female KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Alcoholism -- epidemiology KW - Stress Disorders, Post-Traumatic -- psychology KW - Alcoholism -- diagnosis KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78561327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse&rft.atitle=Characteristics+of+posttraumatic+stress+disorder-alcohol+abuse+comorbidity+in+women.&rft.au=Ouimette%2C+P+C%3BWolfe%2C+J%3BChrestman%2C+K+R&rft.aulast=Ouimette&rft.aufirst=P&rft.date=1996-01-01&rft.volume=8&rft.issue=3&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse&rft.issn=08993289&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-04-02 N1 - Date created - 1997-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of mitoxantrone and tetracycline as pleural sclerosing agents in rabbits. AN - 78474647; 8887932 AB - Bleomycin is the antineoplastic agent used most commonly for the treatment of malignant pleural effusion. It is absorbed rapidly from the pleural space and does not elicit pleurodesis in the normal rabbit pleura. Mitoxantrone is a new antineoplastic that differs from bleomycin in that it binds to membranes. Accordingly it might remain in the pleural space for a longer period and produce a pleurodesis. The objective of this project was to determine whether mitoxantrone is an effective sclerosant in an experimental model in rabbits. The following medications were instilled intrapleurally in anesthetized male rabbits: 35 mg/kg tetracycline or 0.5, 1.0, or 2.0 mg/kg mitoxantrone. The animals were killed at 28 days and the pleural spaces assessed grossly for pleurodesis and microscopically for fibrosis and inflammation. The mean degree of gross pleurodesis did not differ significantly in the rabbits that received tetracycline (3.8 +/- 0.4) and in the rabbits that received 2 mg/kg mitoxantrone (3.2 +/- 1.3). The degree of pleural and lung inflammation was significantly greater after mitoxantrone than after tetracycline, both ipsilaterally and contralaterally. The mortality after the highest dose of mitoxantrone was 50%. From this study we conclude that the intrapleural administration of mitoxantrone in rabbits can produce a pleurodesis. The histologic picture after mitoxantrone administration differs markedly from that after tetracycline injection. After mitoxantrone injection there are many more inflammatory cells present on the side that received the injection, and there is much more fibrosis and inflammation in the contralateral pleura and lung. The model of pleural fibrosis following intrapleural mitoxantrone may be useful for the study of pleural fibrosis. JF - Lung AU - Light, R W AU - Wang, N S AU - Despars, J A AU - Gruer, S E AU - Sassoon, C AU - Vargas, F S AD - Department of Medicine of the Veterans Administration Medical Center Long Beach, California 90822, USA. Y1 - 1996 PY - 1996 DA - 1996 SP - 373 EP - 381 VL - 174 IS - 6 SN - 0341-2040, 0341-2040 KW - Antineoplastic Agents KW - 0 KW - Protein Synthesis Inhibitors KW - Sclerosing Solutions KW - Mitoxantrone KW - BZ114NVM5P KW - Tetracycline KW - F8VB5M810T KW - Index Medicus KW - Animals KW - Fibrosis -- pathology KW - Dose-Response Relationship, Drug KW - Lethal Dose 50 KW - Rabbits KW - Male KW - Sclerosing Solutions -- pharmacology KW - Protein Synthesis Inhibitors -- toxicity KW - Protein Synthesis Inhibitors -- pharmacology KW - Mitoxantrone -- toxicity KW - Tetracycline -- toxicity KW - Pleura -- drug effects KW - Antineoplastic Agents -- toxicity KW - Mitoxantrone -- pharmacology KW - Pleurodesis KW - Pleura -- pathology KW - Tetracycline -- pharmacology KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78474647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lung&rft.atitle=Comparison+of+mitoxantrone+and+tetracycline+as+pleural+sclerosing+agents+in+rabbits.&rft.au=Light%2C+R+W%3BWang%2C+N+S%3BDespars%2C+J+A%3BGruer%2C+S+E%3BSassoon%2C+C%3BVargas%2C+F+S&rft.aulast=Light&rft.aufirst=R&rft.date=1996-01-01&rft.volume=174&rft.issue=6&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Lung&rft.issn=03412040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-02-21 N1 - Date created - 1997-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tumours of the skin. AN - 78445423; 8875259 JF - IARC scientific publications AU - Ghadially, F N AU - Ghadially, R AD - Department of Dermatology, University of California at San Francisco, Veterans Administration Medical Center, USA. Y1 - 1996 PY - 1996 DA - 1996 SP - 1 EP - 43 IS - 126 SN - 0300-5038, 0300-5038 KW - Index Medicus KW - Animals KW - Skin Physiological Phenomena KW - Cricetinae KW - Melanoma -- ultrastructure KW - Melanoma -- chemically induced KW - Soft Tissue Neoplasms -- pathology KW - Skin -- anatomy & histology KW - Skin Neoplasms -- pathology KW - Neoplasms, Glandular and Epithelial -- veterinary KW - Neoplasms, Glandular and Epithelial -- chemically induced KW - Neoplasms, Glandular and Epithelial -- pathology KW - Melanoma -- veterinary KW - Melanoma -- pathology KW - Skin Neoplasms -- chemically induced KW - Soft Tissue Neoplasms -- chemically induced KW - Soft Tissue Neoplasms -- veterinary KW - Skin Neoplasms -- veterinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78445423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IARC+scientific+publications&rft.atitle=Tumours+of+the+skin.&rft.au=Ghadially%2C+F+N%3BGhadially%2C+R&rft.aulast=Ghadially&rft.aufirst=F&rft.date=1996-01-01&rft.volume=&rft.issue=126&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=IARC+scientific+publications&rft.issn=03005038&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-01-14 N1 - Date created - 1997-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of HIV-1 infectivity by low molecular weight heparin. Results of in vitro studies and a pilot clinical trial in patients with advanced AIDS. AN - 78418912; 8856366 AB - Several sulfated polysaccharides have been shown to have anti-HIV activity in vitro. However, many of these compounds are not suited for use in vivo because they present an increased risk of bleeding or cannot be administered chronically. We tested the anti-HIV effects of low molecular weight heparin (LMW-heparin) (Enoxaparin) in vitro using a model system of HIV infectivity because LMW-heparin can be given to patients on a long-term basis with little risk. In vitro, LMW-heparin was shown to inhibit HIV-1 production from a T cell lymphoma line (H9) and phytohemagglutinin-stimulated lymphoblasts. Inhibition of infectivity was dose dependent at concentrations achievable in vivo. We then performed a pilot clinical trial in 13 patients with advanced AIDS of 6 months of chronic, self-administered Enoxaparin given in standard prophylactic doses. CD4 counts appeared to stabilize or increase in most patients during the first 3 months of treatment, then remained stable or declined after 6 months. There was no appreciable change in serum p24 levels. There was no evidence of drug toxicity and no bleeding episodes. These findings demonstrate that a commercially available, relatively non-toxic form of LMW-heparin is a potent inhibitor of HIV-1 production in cultured cells and that it is feasible to treat patients with AIDS with LMW-heparin on a long-term basis. Definitive clinical trials of LMW-heparins and related compounds as experimental anti-viral agents in patients with HIV infection are indicated. JF - International journal of clinical & laboratory research AU - Howell, A L AU - Taylor, T H AU - Miller, J D AU - Groveman, D S AU - Eccles, E H AU - Zacharski, L R AD - Veterans Administration Medical Center, White River Junction, VT 05009, USA. Y1 - 1996 PY - 1996 DA - 1996 SP - 124 EP - 131 VL - 26 IS - 2 SN - 0940-5437, 0940-5437 KW - Anti-HIV Agents KW - 0 KW - Heparin, Low-Molecular-Weight KW - Index Medicus KW - AIDS/HIV KW - Tumor Cells, Cultured KW - Virus Replication -- drug effects KW - Cells, Cultured KW - Humans KW - Adult KW - Treatment Outcome KW - Pilot Projects KW - Retreatment KW - Male KW - Female KW - Anti-HIV Agents -- therapeutic use KW - Heparin, Low-Molecular-Weight -- therapeutic use KW - Acquired Immunodeficiency Syndrome -- drug therapy KW - HIV-1 -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78418912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+clinical+%26+laboratory+research&rft.atitle=Inhibition+of+HIV-1+infectivity+by+low+molecular+weight+heparin.+Results+of+in+vitro+studies+and+a+pilot+clinical+trial+in+patients+with+advanced+AIDS.&rft.au=Howell%2C+A+L%3BTaylor%2C+T+H%3BMiller%2C+J+D%3BGroveman%2C+D+S%3BEccles%2C+E+H%3BZacharski%2C+L+R&rft.aulast=Howell&rft.aufirst=A&rft.date=1996-01-01&rft.volume=26&rft.issue=2&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=International+journal+of+clinical+%26+laboratory+research&rft.issn=09405437&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-01-02 N1 - Date created - 1997-01-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Local cerebral glucose metabolism in patients with long-term behavioral and cognitive deficits following mild traumatic brain injury. AN - 78416634; 8854305 AB - A retrospective study of 20 patients with mild traumatic brain injury (MTBI) examined brain regions of interest by comparing [18F]-2-deoxyglucose PET, neuropsychological test results, and continuing behavioral dysfunction. Abnormal local cerebral metabolic rates (rLCMs) were most prominent in midtemporal, anterior cingulate, precuneus, anterior temporal, frontal white, and corpus callosum brain regions. Abnormal rLCMs were significantly correlated statistically with 1) overall clinical complaints, most specifically with inconsistent attention/concentration and 2) overall neuropsychological test results. The authors conclude that 1) even mild TBI may result in continuing brain behavioral deficits; 2) PET can help elucidate dysfunctional brain circuitry in neurobehavioral disorders; and 3) specific brain areas may correlate with deficits in daily neurobehavioral functioning and neuropsychological test findings. JF - The Journal of neuropsychiatry and clinical neurosciences AU - Gross, H AU - Kling, A AU - Henry, G AU - Herndon, C AU - Lavretsky, H AD - Psychiatry Service, Sepulveda Veterans Administration Medical Center, California, USA. Y1 - 1996 PY - 1996 DA - 1996 SP - 324 EP - 334 VL - 8 IS - 3 SN - 0895-0172, 0895-0172 KW - Antimetabolites KW - 0 KW - Deoxyglucose KW - 9G2MP84A8W KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Humans KW - Retrospective Studies KW - Child KW - Mood Disorders -- etiology KW - Adult KW - Tomography, Emission-Computed KW - Middle Aged KW - Adolescent KW - Neuropsychological Tests KW - Female KW - Male KW - Mood Disorders -- psychology KW - Cognition Disorders -- metabolism KW - Glucose -- metabolism KW - Brain Injuries -- psychology KW - Mental Disorders -- psychology KW - Mental Disorders -- metabolism KW - Cognition Disorders -- psychology KW - Brain Injuries -- metabolism KW - Brain Chemistry -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78416634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuropsychiatry+and+clinical+neurosciences&rft.atitle=Local+cerebral+glucose+metabolism+in+patients+with+long-term+behavioral+and+cognitive+deficits+following+mild+traumatic+brain+injury.&rft.au=Gross%2C+H%3BKling%2C+A%3BHenry%2C+G%3BHerndon%2C+C%3BLavretsky%2C+H&rft.aulast=Gross&rft.aufirst=H&rft.date=1996-01-01&rft.volume=8&rft.issue=3&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuropsychiatry+and+clinical+neurosciences&rft.issn=08950172&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-01-03 N1 - Date created - 1997-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hazards to the orthopaedic trauma surgeon: occupational exposure to tuberculosis. Risk reduction, testing, and treatment (a review article). AN - 78339987; 8814582 AB - Infection with tuberculosis (TB) in the United States has risen over the last decade. In the past 5 years, health care worker exposure to multidrug-resistant TB has lead to more than 100 skin-test conversions, 17 cases of active TB, and at least six deaths. As with human immunodeficiency virus, hepatitis B virus, and hepatitis C virus, the orthopaedic traumatologist is at risk of exposure and infection because, in many cases, the medical histories of patients encountered in the trauma bay cannot be determined until well into the course of care. Risk depends principally on two factors: (a) likelihood of exposure (large urban settings, prisons, concentration of persons from countries with high TB prevalence), and (b) immune status of the surgeon. Prompt recognition, isolation, and appropriate treatment of patients with infectious TB; engineering controls; and the use of personal protective respiratory equipment can help prevent the transmission of TB to health care workers. JF - Journal of orthopaedic trauma AU - Esterhai, J L AU - Reynolds, M R AU - Chou, L AD - Department of Orthopedic Surgery, Veterans Administration Hospital, Philadelphia, Pennsylvania, USA. Y1 - 1996 PY - 1996 DA - 1996 SP - 366 EP - 370 VL - 10 IS - 5 SN - 0890-5339, 0890-5339 KW - Index Medicus KW - AIDS/HIV KW - United States KW - Protective Clothing KW - Risk Factors KW - Humans KW - Incidence KW - Guidelines as Topic KW - Tuberculosis -- therapy KW - Orthopedics KW - Occupational Exposure -- adverse effects KW - Infectious Disease Transmission, Patient-to-Professional -- prevention & control KW - Tuberculosis -- transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78339987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+orthopaedic+trauma&rft.atitle=Hazards+to+the+orthopaedic+trauma+surgeon%3A+occupational+exposure+to+tuberculosis.+Risk+reduction%2C+testing%2C+and+treatment+%28a+review+article%29.&rft.au=Esterhai%2C+J+L%3BReynolds%2C+M+R%3BChou%2C+L&rft.aulast=Esterhai&rft.aufirst=J&rft.date=1996-01-01&rft.volume=10&rft.issue=5&rft.spage=366&rft.isbn=&rft.btitle=&rft.title=Journal+of+orthopaedic+trauma&rft.issn=08905339&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-04 N1 - Date created - 1996-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Essential and reactive alcoholism: a review. AN - 78060973; 8682916 AB - Methodological characteristics and substantive findings of investigations of essential and reactive alcoholics were reviewed. The data base was comprised of approximately 12 studies published between 1951-1992, most of which employed small samples of hospitalized male alcoholics. Psychometric properties of the Essential-Reactive Alcoholism Questionnaire, the instrument generally used to assess the essential-reactive dimensions, rarely were examined. The weight of the evidence suggests that essential alcoholics have earlier onset and greater severity of alcoholism, lower levels of occupational and educational achievement, more interpersonal conflict, fewer long-term friendships, more antisocial attitudes and conduct, greater density of familial alcoholism, more impaired neuropsychological functioning, and lower resting blood pressure than do reactive alcoholics. Research is needed to assess the prognostic utility of the essential-reactive typology and the degree to which the distinction may facilitate patient-treatment matching. JF - Journal of clinical psychology AU - Walker, R D AU - Howard, M O AU - Walker, P S AU - Lambert, M D AU - Maloy, F AU - Suchinsky, R T AD - DATSEP, Veterans Administration Medical Center, Seattle, WA 98108, USA. Y1 - 1996/01// PY - 1996 DA - January 1996 SP - 80 EP - 95 VL - 52 IS - 1 SN - 0021-9762, 0021-9762 KW - Index Medicus KW - Patient Admission KW - Social Adjustment KW - Humans KW - Child of Impaired Parents -- psychology KW - Prognosis KW - Personality Development KW - Personality Assessment KW - Neuropsychological Tests KW - Male KW - Alcoholism -- rehabilitation KW - Alcoholism -- diagnosis KW - Alcoholism -- classification KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/78060973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychology&rft.atitle=Essential+and+reactive+alcoholism%3A+a+review.&rft.au=Walker%2C+R+D%3BHoward%2C+M+O%3BWalker%2C+P+S%3BLambert%2C+M+D%3BMaloy%2C+F%3BSuchinsky%2C+R+T&rft.aulast=Walker&rft.aufirst=R&rft.date=1996-01-01&rft.volume=52&rft.issue=1&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychology&rft.issn=00219762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-08-16 N1 - Date created - 1996-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rusty peritoneal dialysis fluid after intravenous administration of iron dextran. AN - 77898082; 8546131 AB - Rusty-colored peritoneal dialysate fluid was observed after intravenous administration of iron dextran to a patient with peritonitis being treated with vancomycin and rifampicin. The discoloration gradually cleared over a 24-hour period. Analysis of the fluid demonstrated that the discoloration could not be explained by the presence of erythrocytes or free hemoglobin. Iron (52 micrograms/dL) was detected in the fluid and decreased to undetectable levels as the discoloration cleared. Addition of iron dextran to an unused bag of peritoneal dialysis fluid to achieve an iron concentration of 52 micrograms/dL resulted in no discoloration. Addition of rifampicin at a clinically relevant serum concentration (10 micrograms/dL) to a different unused bag caused a light orange discoloration. Addition of iron dextran and rifampicin simultaneously in the concentrations mentioned to an unused bag caused a rusty discoloration almost as dark as that observed in our patient. We postulate, therefore, that a combination of iron and rifampicin caused the marked discoloration of our patient's peritoneal effluent. JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Carter, T B AU - Garris, A G AU - Ullian, M E AD - Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC, USA. Y1 - 1996/01// PY - 1996 DA - January 1996 SP - 147 EP - 150 VL - 27 IS - 1 SN - 0272-6386, 0272-6386 KW - Iron-Dextran Complex KW - 9004-66-4 KW - Index Medicus KW - Injections, Intravenous KW - Humans KW - Middle Aged KW - Male KW - Ascitic Fluid KW - Peritoneal Dialysis KW - Iron-Dextran Complex -- adverse effects KW - Iron-Dextran Complex -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77898082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Rusty+peritoneal+dialysis+fluid+after+intravenous+administration+of+iron+dextran.&rft.au=Carter%2C+T+B%3BGarris%2C+A+G%3BUllian%2C+M+E&rft.aulast=Carter&rft.aufirst=T&rft.date=1996-01-01&rft.volume=27&rft.issue=1&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=02726386&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-02-09 N1 - Date created - 1996-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Implementation of Computerized Social Work Data Base/Assessments AN - 61552817; 199700435 AB - The Social Work Information Management System (SWIMS), designed, developed & implemented by the Dept of Veterans Affairs' Social Work Service in Danville, IL, provides for the collection & reporting of both administrative & clinical information. The implementation of one component of SWIMS, the automated Social Work Data Base/Assessment, is discussed, detailing the implementation process & issues encountered in the implementation of a computerized documentation system. 1 Figure, 15 References. Adapted from the source document. JF - Social Work in Health Care AU - Breeding, William AU - Grishman, Melanie H AU - Moreland, Michael AD - Social Work Service Veterans Administration Medical Center, Danville IL Y1 - 1996///0, PY - 1996 DA - 0, 1996 SP - 81 EP - 98 VL - 23 IS - 2 SN - 0098-1389, 0098-1389 KW - computerized Social Work Information Management System, development/implementation, Department of Veterans Affairs KW - Computers KW - Data Banks KW - Social Work KW - Implementation KW - article KW - 6150: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61552817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=Implementation+of+Computerized+Social+Work+Data+Base%2FAssessments&rft.au=Breeding%2C+William%3BGrishman%2C+Melanie+H%3BMoreland%2C+Michael&rft.aulast=Breeding&rft.aufirst=William&rft.date=1996-01-01&rft.volume=23&rft.issue=2&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Implementation; Social Work; Data Banks; Computers ER - TY - JOUR T1 - Anorexia Nervosa and Bulimia Nervosa in Alcohol-Dependent Men and Women and Their Relatives AN - 61526350; 9609908 AB - Evaluates the relationship between alcohol dependence & eating disorders, drawing on structured interview conducted in 1994 with 4,265 alcohol-dependent men & women & their relatives (as well as a comparison group). Data on drug abuse & dependence, psychiatric disorders, & symptoms of anorexia & bulimia reveal very little correlation between either primary or secondary alcoholism & eating disorders. 4 Tables, 47 References. Adapted from the source document. JF - The American Journal of Psychiatry AU - Schuckit, Marc A AU - Tipp, Jayson E AU - Anthenelli, Robert M AU - Bucholz, Kathleen K AU - Hesselbrock, Victor M AU - Nurnberger, John I, Jr AD - Dept Psychiatry Veterans Administration Medical Center, 3350 La Jolla Village Dr San Diego CA 92161-2002 Y1 - 1996/01// PY - 1996 DA - January 1996 SP - 74 EP - 82 VL - 153 IS - 1 SN - 0002-953X, 0002-953X KW - alcohol dependence-eating disorder link KW - 1994 interview data KW - alcohol-dependent people/their relatives KW - Alcohol Abuse KW - Bulimia KW - Alcoholism KW - Anorexia Nervosa KW - Psychopathology KW - Eating Disorders KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61526350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Anorexia+Nervosa+and+Bulimia+Nervosa+in+Alcohol-Dependent+Men+and+Women+and+Their+Relatives&rft.au=Schuckit%2C+Marc+A%3BTipp%2C+Jayson+E%3BAnthenelli%2C+Robert+M%3BBucholz%2C+Kathleen+K%3BHesselbrock%2C+Victor+M%3BNurnberger%2C+John+I%2C+Jr&rft.aulast=Schuckit&rft.aufirst=Marc&rft.date=1996-01-01&rft.volume=153&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Eating Disorders; Alcoholism; Bulimia; Alcohol Abuse; Psychopathology; Anorexia Nervosa ER - TY - JOUR T1 - Late-Life Problem Drinking: Personal and Environmental Risk Factors for 4-Year Functioning Outcomes and Treatment Seeking AN - 61466391; 9714588 AB - Older problem drinkers (N = 581, ages 55-60, in the US) completed a battery of measures at initial assessment & at 1- & 4-year follow-ups in a prospective study of predictors of alcohol consumption, drinking problems, depression, & treatment seeking. Associated with heavier consumption at the 4-year follow-up were early onset of problem drinking & friends who approved of drinking. Independent predictors were heavier baseline consumption & male gender. More subsequent drinking problems were predicted by more baseline & earlier-onset drinking problems. Depression was associated with higher baseline levels of depressive symptoms, female gender, unmarried status, use of avoidance coping, & more negative life events & chronic health stressors. Initial help seeking & more chronic health & spouse stressors independently predicted greater 4-year treatment seeking, which also correlated with being female, being single, & using avoidance coping. Interactions between baseline & environmental factors are discussed. 1 Table, 2 Figures, 36 References. Adapted from the source document. JF - Journal of Substance Abuse AU - Brennan, Penny L AU - Moos, Rudolf H AD - Center Health Care Evaluation Veterans Administration Health Care System, 3801 Miranda Ave Palo Alto CA 94304 Y1 - 1996///0, PY - 1996 DA - 0, 1996 SP - 167 EP - 180 VL - 8 IS - 2 SN - 0899-3289, 0899-3289 KW - drinking problems/depression/treatment seeking, older adults, personal/environmental predictors KW - longitudinal assessment data KW - US KW - Help Seeking Behavior KW - Alcohol Abuse KW - Depression (Psychology) KW - Middle Aged Adults KW - Treatment KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61466391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse&rft.atitle=Late-Life+Problem+Drinking%3A+Personal+and+Environmental+Risk+Factors+for+4-Year+Functioning+Outcomes+and+Treatment+Seeking&rft.au=Brennan%2C+Penny+L%3BMoos%2C+Rudolf+H&rft.aulast=Brennan&rft.aufirst=Penny&rft.date=1996-01-01&rft.volume=8&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse&rft.issn=08993289&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSABEU N1 - SubjectsTermNotLitGenreText - Alcohol Abuse; Depression (Psychology); Help Seeking Behavior; Treatment; Middle Aged Adults ER - TY - JOUR T1 - Homelessness among Older American Indians, Los Angeles, 1987-1989 AN - 60074960; 9711906 AB - Structured interview data collected 1987-1989 from 335 older American Indians in Los Angeles County (CA) revealed that 16% were homeless. Compared to domiciled older American Indians, homeless older American Indians were younger, yet reported higher rates of physical & mental health problems, including hypertension, shortness of breath, diabetes, chest pains, alcoholism, depression, sadness, & loneliness. Of homeless elders who reported usual habitat, all those age 60+ lived on the street year-round; in contrast, 30% age 60 or less at least occasionally rented rooms for shelter. Institutional & cultural barriers prevented some homeless from accessing social & welfare services. 3 Tables, 80 References. Adapted from the source document. JF - Human Organization AU - Kramer, B Josea AU - Barker, Judith C AD - Geriatric Research Education & Clinical Center Veterans Administration Medical Center, 16111 Plummer Sepulveda CA 91343 Y1 - 1996/01// PY - 1996 DA - January 1996 SP - 396 EP - 408 VL - 55 IS - 4 SN - 0018-7259, 0018-7259 KW - homelessness rate, older American Indians, health problems/welfare services access, Los Angeles County (California) KW - 1987-1989 interviews KW - Los Angeles, California KW - Urban Areas KW - Elderly KW - American Indians KW - Homelessness KW - article KW - 2793: studies in poverty; homelessness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60074960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Organization&rft.atitle=Homelessness+among+Older+American+Indians%2C+Los+Angeles%2C+1987-1989&rft.au=Kramer%2C+B+Josea%3BBarker%2C+Judith+C&rft.aulast=Kramer&rft.aufirst=B&rft.date=1996-01-01&rft.volume=55&rft.issue=4&rft.spage=396&rft.isbn=&rft.btitle=&rft.title=Human+Organization&rft.issn=00187259&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-10-30 N1 - Last updated - 2016-09-28 N1 - CODEN - HUORAY N1 - SubjectsTermNotLitGenreText - American Indians; Homelessness; Elderly; Los Angeles, California; Urban Areas ER - TY - JOUR T1 - The influence of food, beverages and NSAIDs on gastric acid secretion and mucosal integrity. AN - 20313536; 8929201 AB - Gastric acid secretion is stimulated by all foods, especially proteins, and many beverages, the most potent beverages are milk and fermented substances such as beer and wine. The effects of food on mucosal integrity have been little studied, whereas non-steroidal anti-inflammatory drugs are well known to induce tissue injury. JF - Yale Journal of Biology and Medicine AU - Peterson, W L AD - Department of Internal Medicine, University of Texas Southwestern Medical School at Dallas, USA., peterson.w@dallas.va.gov Y1 - 1996 PY - 1996 DA - 1996 SP - 81 EP - 84 PB - Yale Journal of Biology and Medicine, Inc., 333 Cedar St, PO Box 208000 VL - 69 IS - 1 SN - 0044-0086, 0044-0086 KW - Biotechnology and Bioengineering Abstracts KW - Beer KW - Beverages KW - Milk KW - Injuries KW - Food KW - Secretion KW - Mucosa KW - Vitaceae KW - Nonsteroidal antiinflammatory drugs KW - Wine KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20313536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Yale+Journal+of+Biology+and+Medicine&rft.atitle=The+influence+of+food%2C+beverages+and+NSAIDs+on+gastric+acid+secretion+and+mucosal+integrity.&rft.au=Peterson%2C+W+L&rft.aulast=Peterson&rft.aufirst=W&rft.date=1996-01-01&rft.volume=69&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Yale+Journal+of+Biology+and+Medicine&rft.issn=00440086&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Beer; Milk; Beverages; Injuries; Secretion; Food; Mucosa; Wine; Nonsteroidal antiinflammatory drugs; Vitaceae ER - TY - JOUR T1 - Using Interactive Multimedia to Educate High-Risk Patients about AIDS and Sexually Transmitted Diseases AN - 1761697601; 199703245 AB - Military veterans (N = 161) in a Palo Alto, CA, residential program for homelessness & substance dependence received education regarding acquired immune deficiency syndrome (AIDS) & sexually transmitted diseases via interactive videodisc or a didactic class. Questionnaire data revealed that knowledge increased with both methods, with no difference found between methods for either course. Similarly, with both methods, attitude ratings reflected some increased tolerance toward persons with AIDS. Participants rated both courses highly, with no clear preference indicated for either method. Although some problems exist with interactive multimedia technology (eg, variable quality of software), it appears to be a viable method for educating high-risk patients about AIDS & sexually transmitted diseases. 3 Tables, 23 References. Adapted from the source document. JF - Computers in Human Services AU - Seidner, Andrea L AU - Burling, Thomas A AU - Marshall, Gary D AD - Domiciliary Services 180D Palo Alto Veterans Administration Health Care System, 3801 Miranda Ave Palo Alto CA 94304 Y1 - 1996///0, PY - 1996 DA - 0, 1996 SP - 1 EP - 15 VL - 13 IS - 4 SN - 0740-445X, 0740-445X KW - acquired immune deficiency syndrome/sexually transmitted disease risks, interactive multimedia education method KW - questionnaire KW - homeless/substance abusing veterans, residential program, Palo Alto, California KW - California KW - Veterans KW - Substance Abuse KW - Acquired Immune Deficiency Syndrome KW - Sex Information KW - Venereal Diseases KW - Computer Assisted Instruction KW - Health Education KW - Homelessness KW - Teaching Methods KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761697601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computers+in+Human+Services&rft.atitle=Using+Interactive+Multimedia+to+Educate+High-Risk+Patients+about+AIDS+and+Sexually+Transmitted+Diseases&rft.au=Seidner%2C+Andrea+L%3BBurling%2C+Thomas+A%3BMarshall%2C+Gary+D&rft.aulast=Seidner&rft.aufirst=Andrea&rft.date=1996-01-01&rft.volume=13&rft.issue=4&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Computers+in+Human+Services&rft.issn=0740445X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health Education; Acquired Immune Deficiency Syndrome; Teaching Methods; Computer Assisted Instruction; Venereal Diseases; Sex Information; Homelessness; Substance Abuse; Veterans; California ER - TY - JOUR T1 - Effects of cocaine on human platelet aggregation in vitro AN - 15833822; 4007868 AB - Background: A temporal relationship has been established between cocaine ingestion and myocardial infarction, and a cocaine-induced increase in platelet aggregation has been suggested as a possible explanation. However, the mechanisms of cocaine associated coronary thrombosis have yet to be completely elucidated. For this reason, we examined the in vitro effect of cocaine and its metabolites on platelet aggregation. Methods: Platelet aggregation was tested by obtaining platelet rich plasma from 42 healthy volunteers and incubating the platelet rich plasma in six concentrations of cocaine (ranging from 1.47 to 2940 nmol) for 10 minutes prior to aggregation with ADP 1 mu M. The same procedure was used to test the effect of two cocaine metabolites, benzoylecgonine and ecgonine methyl ester, on platelet aggregation. Abnormal results were confirmed by inducing aggregation with ADP at higher concentrations (2.4 and 10 mu M) and with arachidonic acid (624 mu M). Results: At increasing concentrations, cocaine progressively inhibited ADP and arachidonic acid induced platelet aggregation. No effect was seen with benzoyl ecgonine or ecgonine methyl ester as compared to saline. Conclusions: These data suggest that under certain conditions cocaine may negatively affect hemostasis by decreasing platelet aggregation. JF - Journal of Toxicology: Clinical Toxicology AU - Heesch, C M AU - Steiner, M AU - Hernandez, JA AU - Ashcraft, J AU - Eichhorn, E J AD - Cardiac Catheterization Laboratory (III A2), University of Texas Southwestern and Dallas Veterans Administration Medical Centers, 4500 S. Lancaster Road, Dallas, TX 75216, USA Y1 - 1996 PY - 1996 DA - 1996 SP - 673 EP - 684 VL - 34 IS - 6 SN - 0731-3810, 0731-3810 KW - in vitro KW - normal subjects KW - man KW - cocaine KW - benzoylecgonine KW - ecgonine methyl ester KW - Toxicology Abstracts KW - myocardial infarction KW - platelet aggregation KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15833822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology%3A+Clinical+Toxicology&rft.atitle=Effects+of+cocaine+on+human+platelet+aggregation+in+vitro&rft.au=Heesch%2C+C+M%3BSteiner%2C+M%3BHernandez%2C+JA%3BAshcraft%2C+J%3BEichhorn%2C+E+J&rft.aulast=Heesch&rft.aufirst=C&rft.date=1996-01-01&rft.volume=34&rft.issue=6&rft.spage=673&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology%3A+Clinical+Toxicology&rft.issn=07313810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - platelet aggregation; myocardial infarction ER - TY - JOUR T1 - Human wrist motors: biomechanical design and application to tendon transfers AN - 15701147; 208094 AB - Moment arm, muscle architecture, and tendon compliance in cadaveric human forearms were determined and used to model the wrist torque-joint angle relation (i.e. wrist torque profile). Instantaneous moment arms were calculated by differentiating tendon excursion with respect to joint rotation. Maximum isometric tension of each wrist muscle-tendon unit was predicted based on muscle physiological cross-sectional area. Muscle forces were subsequently adjusted for sarcomere length changes resulting from joint rotation and tendon strain. Torque profiles were then calculated for each prime wrist motor (i.e. muscle-tendon unit operating through the corresponding moment arm). Influences of moment arm, muscle force, and tendon compliance on the torque profile of each motor were quantified. Wrist extensor motor torque varied considerably throughout the range of motion. The contours of the extensor torque profiles were determined primarily by the moment arm-joint angle relations. In contrast, wrist flexor motors produced near-maximal torque over the entire range of motion. Flexor torque profiles were less influenced by moment arm and more dependent on muscle force variations with wrist rotation and with tendon strain. These data indicate that interactions between the joint, muscle, and tendon yield a unique torque profile for each wrist motor. This information has significant implications for biomechanical modeling and surgical tendon transfer. JF - Journal of Biomechanics AU - Loren, G J AU - Shoemaker, S D AU - Burkholder, T J AU - Jacobson, MD AU - Friden, J AU - Lieber, R L AD - Univ of California and Veterans Administration Medical Cent, San Diego, La Jolla, USA Y1 - 1996 PY - 1996 DA - 1996 SP - 331 EP - 342 PB - PERGAMON PRESS LTD, OXFORD, (ENGL) VL - 29 IS - 3 SN - 0021-9290, 0021-9290 KW - Cadaveric experiments KW - Calculations KW - Human wrist motors KW - Joints (anatomy) KW - Moment arm KW - Muscle KW - Muscle architecture KW - Sarcomere length KW - Torque KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Physiology KW - Rotation KW - Strain KW - Tendons KW - W4 461.2:BIOLOGICAL MATERIALS KW - W4 461.3:BIOMECHANICS KW - W4 461.1:BIOMEDICAL ENGINEERING KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15701147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanics&rft.atitle=Human+wrist+motors%3A+biomechanical+design+and+application+to+tendon+transfers&rft.au=Loren%2C+G+J%3BShoemaker%2C+S+D%3BBurkholder%2C+T+J%3BJacobson%2C+MD%3BFriden%2C+J%3BLieber%2C+R+L&rft.aulast=Loren&rft.aufirst=G&rft.date=1996-01-01&rft.volume=29&rft.issue=3&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomechanics&rft.issn=00219290&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Physiology; Rotation; Strain; Tendons ER - TY - JOUR T1 - In vivo suppression of the renal Na super(+)/P sub(i) cotransporter by antisense oligonucleotides AN - 15570158; 3907229 AB - A 20-mer phosphorothioate oligonucleotide (AS1) was designed to hybridize to the message for the rat kidney sodium phosphate cotransporter NaPi-2 close to the translation initiation site. Single intravenous doses of this oligonucleotide were given to rats maintained on a low phosphorus diet to increase NaPi-2 expression. At 3 days after oligonucleotide infusion, rats receiving 2.5 mu mol of AS1 exhibited a reduction in renal NaPi-2 to cyclophilin mRNA ratio by 40% plus or minus 17%, and rats receiving 7.5 mu mol of AS1 exhibited a reduction in NaPi-2 to cyclophilin mRNA ratio by 46% plus or minus 21%. Reversed-sequence AS1 was without effect. The higher dose of 7.5 mu mol of AS1 also reduced the rate of phosphate uptake into renal brush border membrane vesicles and the expression of NaPi-2 protein detected by Western blotting in these vesicles. Reversed sequence AS1 was again without effect on these parameters. These results suggest that systemically infused oligonucleotides can exert antisense effects in the renal proximal tubule. JF - Proceedings of the National Academy of Sciences, USA AU - Oberbauer, R AU - Schreiner, G F AU - Biber, J AU - Murer, H AU - Meyer, T W AD - Dep. Med., Palo Alto Veterans Administration Med. Cent. and Stanford Univ., Palo Alto, CA 94303, USA Y1 - 1996 PY - 1996 DA - 1996 SP - 4903 EP - 4906 VL - 93 IS - 10 SN - 0027-8424, 0027-8424 KW - Na super(+)/P sub(i) cotransporter KW - cyclophilin KW - oligodeoxyribonucleotides KW - rats KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - antisense KW - RNA KW - N 14250:Biological properties KW - W 30965:Miscellaneous, Reviews KW - W3 33380:Antisense UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15570158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=In+vivo+suppression+of+the+renal+Na+super%28%2B%29%2FP+sub%28i%29+cotransporter+by+antisense+oligonucleotides&rft.au=Oberbauer%2C+R%3BSchreiner%2C+G+F%3BBiber%2C+J%3BMurer%2C+H%3BMeyer%2C+T+W&rft.aulast=Oberbauer&rft.aufirst=R&rft.date=1996-01-01&rft.volume=93&rft.issue=10&rft.spage=4903&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - antisense; RNA ER - TY - JOUR T1 - A noninvasive stable-isotope method to simultaneously assess pancreatic exocrine function and small bowel absorption. AN - 85226159; pmid-8540512 AB - OBJECTIVE: To determine if a single-step noninvasive stable isotope method of assessing digestive function could separate normal subjects from subjects with pancreatic insufficiency (maldigestion) or small bowel dysfunction (malabsorption) and to see if subjects with maldigestion could be simultaneously separated from subjects with malabsorption. METHODS: Forty (40) normal volunteers, 18 adults with cystic fibrosis and four adults with celiac sprue, ingested a liquid test meal along with bentiromide, [13C6]PABA, and xylose (PABAX test). Serum was collected at 1 h and analyzed for PABA, [13C6]PABA, and xylose by stable isotope dilution methods using gas chromatography mass spectrometry. RESULTS: All subjects with cystic fibrosis had abnormal pancreatic function test results, whereas three of four adults with sprue had normal values of pancreatic function. All subjects with sprue had abnormal small bowel absorption tests, whereas all adults with cystic fibrosis had apparently normal intestinal function. CONCLUSION: The one-step, 1-h PABAX test can reliably separate normal subjects from those with either maldigestion or malabsorption and can also separate subjects with maldigestion from those with malabsorption. JF - The American Journal of Gastroenterology AU - Deutsch, J C AU - Santhosh-Kumar, C R AU - Kolli, V R AD - Veterans Administration Hospital, Denver, Colorado, USA. PY - 1995 SP - 2182 EP - 2185 VL - 90 IS - 12 SN - 0002-9270, 0002-9270 KW - Reference Values KW - Xylose KW - Support, U.S. Gov't, P.H.S. KW - Diagnosis, Differential KW - Human KW - Pancreas KW - Pancreatic Insufficiency KW - Intestinal Diseases KW - 4-Aminobenzoic Acid KW - Cystic Fibrosis KW - Adult KW - Intestine, Small KW - Absorption KW - Malabsorption Syndromes KW - Support, U.S. Gov't, Non-P.H.S. KW - Celiac Disease KW - Carbon Isotopes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85226159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=A+noninvasive+stable-isotope+method+to+simultaneously+assess+pancreatic+exocrine+function+and+small+bowel+absorption.&rft.au=Deutsch%2C+J+C%3BSanthosh-Kumar%2C+C+R%3BKolli%2C+V+R&rft.aulast=Deutsch&rft.aufirst=J&rft.date=1995-12-01&rft.volume=90&rft.issue=12&rft.spage=2182&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Age-dependent inhibition of long-term potentiation by ethanol in immature versus mature hippocampus. AN - 77886228; 8749814 AB - The goal of this study was to assess the effects of ethanol on the induction of long-term potentiation (LTP) in hippocampal slices from immature versus mature rats. Population excitatory postsynaptic potentials (pEPSPs) were recorded from stratum radiatum of area CA1 of hippocampal slices using electrical stimulation of the Schaffer collateral/commissural fiber pathway. The slices were prepared from rats aged 15 to 25 or from 70 to 100 days. Long-term potentiation (LTP) of the pEPSP slope was induced using a single, theta-burst stimulus train in the presence or absence of 60 mM ethanol. Under control conditions, the stimulus train induced LTP in slices from both immature and mature animals. However, the magnitude of LTP was greater in slices from immature rats. When ethanol was present during the stimulus train, the magnitude of LTP in slices from mature animals did not differ significantly from the magnitude of LTP in control slices. However, ethanol virtually blocked the induction of LTP in slices from immature animals. These results indicate that memory-related synaptic plasticity in the hippocampus is attenuated by ethanol to a greater degree in immature versus mature animals. JF - Alcoholism, clinical and experimental research AU - Swartzwelder, H S AU - Wilson, W A AU - Tayyeb, M I AD - Neurobiology Research Laboratory, Veterans Administration Medical Center, Durham, North Carolina 27705, USA. Y1 - 1995/12// PY - 1995 DA - December 1995 SP - 1480 EP - 1485 VL - 19 IS - 6 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Nerve Fibers -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Culture Techniques KW - Age Factors KW - Synapses -- drug effects KW - Neuronal Plasticity -- drug effects KW - Membrane Potentials -- drug effects KW - Male KW - Long-Term Potentiation -- drug effects KW - Ethanol -- toxicity KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77886228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Age-dependent+inhibition+of+long-term+potentiation+by+ethanol+in+immature+versus+mature+hippocampus.&rft.au=Swartzwelder%2C+H+S%3BWilson%2C+W+A%3BTayyeb%2C+M+I&rft.aulast=Swartzwelder&rft.aufirst=H&rft.date=1995-12-01&rft.volume=19&rft.issue=6&rft.spage=1480&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-09-26 N1 - Date created - 1996-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epidermal growth factor induces Egr-1 messenger RNA and protein in mouse osteoblastic cells. AN - 77812679; 8581878 AB - The nuclear signaling events activated when epidermal growth factor (EGF) interacts with osteoblasts to produce effects on growth and differentiation are not clearly understood, and may include induction of immediate early genes such as Egr-1, a zinc finger transcription factor. In the present study, Northern analyses were performed to define the effects of EGF on the expression of Egr-1 mRNA in MC3T3-E1 mouse osteoblastic cells. Following treatment of quiescent, subconfluent MC3T3-E1 cells with 0.1-100 ng/ml EGF for various periods, maximal induction of Egr-1 mRNA occurred when cells were treated for 30-60 minutes with 1-10 ng/ml EGF. Inhibition of protein kinase C activity by pretreatment with 1 microM chelerythrine chloride or by prolonged stimulation with 50 ng/ml tetradecanoyl phorbol acetate (TPA) partially diminished the induction of Egr-1 by EGF. Using an immunohistochemical approach, 10 ng/ml EGF was observed to induce Egr-1 protein within 30-60 minutes and this induction was localized to the nucleus. These observations indicate that EGF induces Egr-1 mRNA and protein via protein kinase C and other signaling pathways, and that Egr-1 may be part of the regulatory network mediating the actions of EGF on growth and differentiation of osteoblasts. JF - Calcified tissue international AU - Fang, M A AU - Noguchi, G M AU - McDougall, S AD - Geriatric Research, Education and Clinical Center, Veterans Health Administration Medical Center, Los Angeles, California 90073, USA. Y1 - 1995/12// PY - 1995 DA - December 1995 SP - 450 EP - 455 VL - 57 IS - 6 SN - 0171-967X, 0171-967X KW - DNA-Binding Proteins KW - 0 KW - Early Growth Response Protein 1 KW - Egr1 protein, mouse KW - Immediate-Early Proteins KW - Protein Synthesis Inhibitors KW - RNA, Messenger KW - Transcription Factors KW - Epidermal Growth Factor KW - 62229-50-9 KW - DNA KW - 9007-49-2 KW - Cycloheximide KW - 98600C0908 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Base Sequence KW - Protein Synthesis Inhibitors -- pharmacology KW - Cycloheximide -- pharmacology KW - Molecular Sequence Data KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Mice KW - Cell Line KW - Osteoblasts -- metabolism KW - Osteoblasts -- drug effects KW - RNA, Messenger -- metabolism KW - DNA-Binding Proteins -- genetics KW - DNA-Binding Proteins -- biosynthesis KW - Epidermal Growth Factor -- pharmacology KW - Transcription Factors -- genetics KW - Transcription Factors -- biosynthesis KW - Osteoblasts -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77812679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Calcified+tissue+international&rft.atitle=Epidermal+growth+factor+induces+Egr-1+messenger+RNA+and+protein+in+mouse+osteoblastic+cells.&rft.au=Fang%2C+M+A%3BNoguchi%2C+G+M%3BMcDougall%2C+S&rft.aulast=Fang&rft.aufirst=M&rft.date=1995-12-01&rft.volume=57&rft.issue=6&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Calcified+tissue+international&rft.issn=0171967X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-03-19 N1 - Date created - 1996-03-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hostility and Erosion of Marital Quality during Early Marriage AN - 61494621; 9609715 AB - Draws on scale & inventory data to examine the association between hostility & longitudinal changes in marital quality in a sample of 53 newlywed couples who were in their first marriages & were without children. Spouses' reports of marital quality were assessed initially at an average of 5 months into marriage &, thereafter, at 3 follow-up points approximately 1, 2, & 3 years subsequent to the date of marriage. Individual growth models were computed to assess the rate of change of marital quality. Hostility among husbands was significantly associated with linear decreases in their own, & their wives', reports of marital quality, even after controlling for the passage of time & the correlated variable of neuroticism. Results are consistent with T. W. Smith's (1992) psychosocial vulnerability model of hostility & illness, which posits that associations between hostility & heightened risk for morbidity & mortality are partially mediated by poor-quality relationships that develop as a consequence of the abrasive interpersonal properties of hostility. 3 Tables, 40 References. Adapted from the source document. JF - Journal of Behavioral Medicine AU - Newton, Tamara L AU - Kiecolt-Glaser, Janice K AD - National Center Posttraumatic Stress Disorder Veterans Administration Medical Center, 116B-3 50 South Huntington St Boston MA 02130 Y1 - 1995/12// PY - 1995 DA - December 1995 SP - 601 EP - 619 VL - 18 IS - 6 SN - 0160-7715, 0160-7715 KW - marital quality decline-hostility relationship, newlywed couples KW - scale/inventory data KW - Husbands KW - Marital Relations KW - Wives KW - Hostility KW - Marriage KW - Marital Satisfaction KW - Spouses KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61494621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Medicine&rft.atitle=Hostility+and+Erosion+of+Marital+Quality+during+Early+Marriage&rft.au=Newton%2C+Tamara+L%3BKiecolt-Glaser%2C+Janice+K&rft.aulast=Newton&rft.aufirst=Tamara&rft.date=1995-12-01&rft.volume=18&rft.issue=6&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Medicine&rft.issn=01607715&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JBMEDD N1 - SubjectsTermNotLitGenreText - Marital Relations; Hostility; Spouses; Marriage; Marital Satisfaction; Husbands; Wives ER - TY - JOUR T1 - Naming Ability across the Adult Life Span AN - 58320414; 9607571 AB - Longitudinal performance on the Boston Naming Test was evaluated in normal Ss (N = 53, aged 30-79) who were tested three times over a seven-year span. Naming performance showed a significant decline over time that was greatest for the oldest Ss. It is concluded that decline in naming is a real phenomenon in normal aging that is not primarily attributable to cohort effects & reflects more than simply a breakdown in lexical retrieval, as perceptual & semantic processing may be implicated. 5 Tables, 5 Figures, 29 References. Adapted from the source document JF - Aging and Cognition AU - Au, Rhoda AU - Joung, Philip AU - Nicholas, Marjorie AU - Obler, Loraine K AU - Kass, Robin AU - Albert, Martin L AD - c/o Nicholas-Audiology & Speech Pathology Service Dept Veterans Affairs Medical Center, 150 South Huntington Ave Boston MA 02130 [Tel: 617-232-9500; mailto:nicholas.marjorie@boston.va.gov] Y1 - 1995/12// PY - 1995 DA - December 1995 SP - 300 EP - 311 VL - 2 IS - 4 SN - 0928-9917, 0928-9917 KW - naming ability KW - age difference KW - Boston Naming Test KW - adults aged 30-79 KW - 7-year longitudinal study KW - Age Differences (01150) KW - Longitudinal Studies (49900) KW - Semantic Processing (76760) KW - article KW - 4012: psycholinguistics; language and cognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58320414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aging+and+Cognition&rft.atitle=Naming+Ability+across+the+Adult+Life+Span&rft.au=Au%2C+Rhoda%3BJoung%2C+Philip%3BNicholas%2C+Marjorie%3BObler%2C+Loraine+K%3BKass%2C+Robin%3BAlbert%2C+Martin+L&rft.aulast=Au&rft.aufirst=Rhoda&rft.date=1995-12-01&rft.volume=2&rft.issue=4&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=Aging+and+Cognition&rft.issn=09289917&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AGCOEW N1 - SubjectsTermNotLitGenreText - Semantic Processing (76760); Age Differences (01150); Longitudinal Studies (49900) ER - TY - JOUR T1 - Acute hepatotoxicity of acetaminophen in rats treated with ethanol plus isopentanol. AN - 77743182; 8615851 AB - Acetaminophen (APAP) hepatotoxicity was investigated in rats fed ethanol and isopentanol alone or in combination in a liquid diet for 7 days. Serum levels of aspartate aminotransferase (AST) and histological examination of liver slices were used to assess hepatotoxicity. At 7 hr after intragastric administration of 0.5 or 1.0 g APAP/kg, there was no significant increase in serum levels of AST in rats treated with APAP alone, or in rats pretreated with ethanol or isopentanol alone followed by APAP. There was mild central lobular congestion in the livers of rats pretreated with ethanol alone followed by APAP. In contrast, in rats pretreated with the combination of ethanol and isopentanol, administration of APAP caused a dramatic increase in serum levels of AST, along with marked central lobular necrosis, including steatosis and ischemic changes. Hepatic glutathione levels were decreased to 40-50% of control values in APAP-treated rats that had been pretreated with ethanol either alone or in combination with isopentanol. The serum concentrations of APAP were significantly lower in rats pretreated with the combination of ethanol and isopentanol followed by 1 g APAP/kg than in rats treated with APAP alone, suggesting a greater rate of APAP metabolism. We had reported previously that combined treatment of rats with ethanol and isopentanol resulted in additive to synergistic increases in CYP3A, with no further increases in CYP2E than that caused by ethanol alone. CYP3A may, therefore, be responsible for the increased APAP hepatotoxicity caused by the combined alcohol treatment. JF - Biochemical pharmacology AU - Kostrubsky, V E AU - Wood, S G AU - Bush, M D AU - Szakacs, J AU - Bement, W J AU - Sinclair, P R AU - Jeffery, E H AU - Sinclair, J F AD - Veterans Administration Medical Center, White River Junction, VT 05009, USA. Y1 - 1995/11/27/ PY - 1995 DA - 1995 Nov 27 SP - 1743 EP - 1748 VL - 50 IS - 11 SN - 0006-2952, 0006-2952 KW - Pentanols KW - 0 KW - Acetaminophen KW - 362O9ITL9D KW - Ethanol KW - 3K9958V90M KW - isopentyl alcohol KW - DEM9NIT1J4 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Rats KW - Aspartate Aminotransferases -- blood KW - Animals KW - Rats, Inbred F344 KW - Necrosis KW - Liver -- pathology KW - Drug Interactions KW - Liver -- drug effects KW - Glutathione -- metabolism KW - Liver -- metabolism KW - Time Factors KW - Male KW - Chemical and Drug Induced Liver Injury -- etiology KW - Chemical and Drug Induced Liver Injury -- pathology KW - Pentanols -- administration & dosage KW - Ethanol -- administration & dosage KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77743182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Acute+hepatotoxicity+of+acetaminophen+in+rats+treated+with+ethanol+plus+isopentanol.&rft.au=Kostrubsky%2C+V+E%3BWood%2C+S+G%3BBush%2C+M+D%3BSzakacs%2C+J%3BBement%2C+W+J%3BSinclair%2C+P+R%3BJeffery%2C+E+H%3BSinclair%2C+J+F&rft.aulast=Kostrubsky&rft.aufirst=V&rft.date=1995-11-27&rft.volume=50&rft.issue=11&rft.spage=1743&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-06-06 N1 - Date created - 1996-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acute renal failure after administration of intravenous immunoglobulin: review of the literature and case report. AN - 77853158; 8602385 AB - Within in last 7 years the literature has published several reports of acute renal failure after the administration of intravenous immunoglobulin. Review of these cases finds that all occurrences in the United States except one involved a sucrose-containing immunoglobulin preparation, leading to the suspicion that sucrose may be the cause of the renal failure. Further investigation found that approximately 50 years ago, when sucrose was used as an osmotic diuretic, investigators reported acute renal failure in humans after intravenous infusions of 50 g or more. A patient at our institution developed acute renal failure similar to that described in published case reports after being administered a sucrose-containing immunoglobulin. JF - Pharmacotherapy AU - Winward, D B AU - Brophy, M T AD - Section of Clinical Pharmacy, Veterans Administration Medical Center, Boston, Massachusetts, USA. PY - 1995 SP - 765 EP - 772 VL - 15 IS - 6 SN - 0277-0008, 0277-0008 KW - Immunoglobulins, Intravenous KW - 0 KW - Sucrose KW - 57-50-1 KW - Index Medicus KW - United States KW - Humans KW - Aged KW - Gingival Hemorrhage -- complications KW - Male KW - Sucrose -- chemistry KW - Sucrose -- adverse effects KW - Acute Kidney Injury -- chemically induced KW - Immunoglobulins, Intravenous -- chemistry KW - Immunoglobulins, Intravenous -- adverse effects KW - Immunoglobulins, Intravenous -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77853158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Acute+renal+failure+after+administration+of+intravenous+immunoglobulin%3A+review+of+the+literature+and+case+report.&rft.au=Winward%2C+D+B%3BBrophy%2C+M+T&rft.aulast=Winward&rft.aufirst=D&rft.date=1995-11-01&rft.volume=15&rft.issue=6&rft.spage=765&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-05-09 N1 - Date created - 1996-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anti-neutrophil serum attenuates dextran sulfate sodium-induced colonic damage in the rat. AN - 77824674; 8578169 AB - The role of neutrophils in experimental colonic damage induced by dextran sulfate sodium is uncertain. We test the hypothesis that neutrophils are of pathogenic significance and anti-neutrophil serum will attenuate the colonic damage induced by oral dextran sulfate sodium in rats. Rabbit anti-rat neutrophil serum (anti-neutrophil serum) or control rabbit serum was administered to, and circulating neutrophil count was monitored in, rats before and during feeding of dextran sulfate sodium or regular rat diet for 2 weeks. Histologic features of mucosal damage were evaluated in hematoxylin and eosin-stained proximal and distal colonic sections by a blinded observer. Oral dextran sulfate sodium induces weight loss, diarrhea, peripheral neutrophilia, and colonic damage. Anti-neutrophil serum induced neutropenia and significantly attenuated the weight loss, the neutrophil infiltration in the colon, and the mucosal necrosis and pathologic index in the distal colon. The data showing that anti-neutrophil serum attenuates distal colonic mucosal injury induced by dextran sulfate sodium support the hypothesis that neutrophils play a pathogenic role in this model of colonic mucosal damage. JF - Scandinavian journal of gastroenterology AU - Domek, M J AU - Iwata, F AU - Blackman, E I AU - Kao, J AU - Baker, M AU - Vidrich, A AU - Leung, F W AD - Research Service, Sepulveda Veterans Administration Medical Center, CA 91343, USA. Y1 - 1995/11// PY - 1995 DA - November 1995 SP - 1089 EP - 1094 VL - 30 IS - 11 SN - 0036-5521, 0036-5521 KW - Immune Sera KW - 0 KW - Dextran Sulfate KW - 9042-14-2 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Necrosis KW - Intestinal Mucosa -- pathology KW - Rabbits KW - Male KW - Leukocyte Count KW - Colonic Diseases -- chemically induced KW - Neutrophils -- immunology KW - Colonic Diseases -- pathology KW - Neutrophils -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77824674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+journal+of+gastroenterology&rft.atitle=Anti-neutrophil+serum+attenuates+dextran+sulfate+sodium-induced+colonic+damage+in+the+rat.&rft.au=Domek%2C+M+J%3BIwata%2C+F%3BBlackman%2C+E+I%3BKao%2C+J%3BBaker%2C+M%3BVidrich%2C+A%3BLeung%2C+F+W&rft.aulast=Domek&rft.aufirst=M&rft.date=1995-11-01&rft.volume=30&rft.issue=11&rft.spage=1089&rft.isbn=&rft.btitle=&rft.title=Scandinavian+journal+of+gastroenterology&rft.issn=00365521&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-03-11 N1 - Date created - 1996-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dose-dependent effect of continuous subcutaneous verapamil infusion on experimental acute pancreatitis in mice. AN - 77708572; 7587813 AB - Calcium antagonists may limit experimental tissue injury by membrane stabilization. We studied the effects of verapamil on pancreatic ultrastructure and zymogen extraction during diet-induced acute pancreatitis. Acute pancreatitis was induced in female Swiss-Webster mice by feeding a choline- and methionine-deficient diet (CD) supplemented with 1% ethionine (CDE). Varying doses of verapamil in normal saline were infused continuously at a rate of 0.5 microliter/hr for 96 hr through subcutaneously implanted osmotic pumps. The pancreata were examined blindly by light microscopy and by electron microscopy. Zymogen extracted from pancreatic tissue was measured and expressed per gram of protein. Mean histological scores, calculated according to a formula that incorporates the extent of necrosis, inflammation, acidophilia, and edema, were 14.1 +/- 4, 10.3 +/- 2, 9.9 +/- 4, 5.9 +/- 7, 12.5 +/- 4, and 12.7 +/- 4 for CDE-fed animals receiving 0, 0.14, 0.28, 0.56, 0.84, and 1.12 microM verapamil daily, respectively. Animals fed normal diet or CD had scores of 0 +/- 0. Histological scores were significantly lower in animals treated with 0.56 microns verapamil compared to animals who received no verapamil (p < 0.05) and was associated with reduced dissolution of the zymogen granule membrane on EM. Mean extracted trypsinogen and chymotrypsinogen content were reduced in the CD- and CDE-fed mice. The reduction in mean trypsinogen content reached statistical significance in CDE-fed mice treated with verapamil 0.56 microM daily. Mean chymotrypsinogen content was also significantly reduced CD-mice and in mice treated with 0.56 microns and 0.84 microM of verapamil daily. Increasing doses of verapamil protect against diet-induced pancreatitis in mice.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Digestive diseases and sciences AU - Lake-Bakaar, G AU - Lyubsky, S AD - Department of Medicine, Veterans Administration Medical Center, Northport, New York, USA. Y1 - 1995/11// PY - 1995 DA - November 1995 SP - 2349 EP - 2355 VL - 40 IS - 11 SN - 0163-2116, 0163-2116 KW - Calcium Channel Blockers KW - 0 KW - Enzyme Precursors KW - Methionine KW - AE28F7PNPL KW - Verapamil KW - CJ0O37KU29 KW - Choline KW - N91BDP6H0X KW - Ethionine KW - WX1BN24WZT KW - Abridged Index Medicus KW - Index Medicus KW - Acute Disease KW - Cytoplasmic Granules -- ultrastructure KW - Animals KW - Enzyme Precursors -- metabolism KW - Dose-Response Relationship, Drug KW - Pancreas -- metabolism KW - Infusion Pumps, Implantable KW - Mice KW - Pancreas -- ultrastructure KW - Female KW - Pancreatitis -- pathology KW - Verapamil -- administration & dosage KW - Calcium Channel Blockers -- pharmacology KW - Calcium Channel Blockers -- administration & dosage KW - Pancreatitis -- metabolism KW - Verapamil -- pharmacology KW - Pancreatitis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77708572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Dose-dependent+effect+of+continuous+subcutaneous+verapamil+infusion+on+experimental+acute+pancreatitis+in+mice.&rft.au=Lake-Bakaar%2C+G%3BLyubsky%2C+S&rft.aulast=Lake-Bakaar&rft.aufirst=G&rft.date=1995-11-01&rft.volume=40&rft.issue=11&rft.spage=2349&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-12-28 N1 - Date created - 1995-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationship between intact 1-84 parathyroid hormone and bone histomorphometric parameters in dialysis patients without aluminum toxicity. AN - 77645666; 7485142 AB - With the markedly reduced usage of aluminum salts in renal failure, parathyroid hormone (PTH) has become the major determinant of currently seen bone disease. Clinicians now must consider what PTH level should be sought. Too low a level may lead to the aplastic bone lesion (low turnover bone), and too high a level may cause osteitis fibrosa. Furthermore, conventional normal PTH levels may not be a suitable target because of the well-known resistance to PTH in uremic patients. In this report, we derive the PTH levels that best distinguish patients with low and high bone formation states from those with normal bone formation in a group of 175 dialysis patients without aluminum toxicity. Using bone histological parameters, we propose that ideally PTH levels should be maintained between 10 pmol/L (100 pg/mL) and 20 to 30 pmol/L (200 to 300 pg/mL) in chronic dialysis patients, levels two to four times the upper limit of values found in normal subjects. JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Wang, M AU - Hercz, G AU - Sherrard, D J AU - Maloney, N A AU - Segre, G V AU - Pei, Y AD - Department of Medicine, Veterans Administration Hospital, Seattle, WA, USA. Y1 - 1995/11// PY - 1995 DA - November 1995 SP - 836 EP - 844 VL - 26 IS - 5 SN - 0272-6386, 0272-6386 KW - Parathyroid Hormone KW - 0 KW - Osteocalcin KW - 104982-03-8 KW - Aluminum KW - CPD4NFA903 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Index Medicus KW - Chronic Kidney Disease-Mineral and Bone Disorder -- blood KW - ROC Curve KW - Chronic Kidney Disease-Mineral and Bone Disorder -- pathology KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Alkaline Phosphatase -- blood KW - Male KW - Female KW - Osteocalcin -- blood KW - Peritoneal Dialysis -- adverse effects KW - Bone and Bones -- pathology KW - Renal Dialysis KW - Aluminum -- poisoning KW - Parathyroid Hormone -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77645666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Relationship+between+intact+1-84+parathyroid+hormone+and+bone+histomorphometric+parameters+in+dialysis+patients+without+aluminum+toxicity.&rft.au=Wang%2C+M%3BHercz%2C+G%3BSherrard%2C+D+J%3BMaloney%2C+N+A%3BSegre%2C+G+V%3BPei%2C+Y&rft.aulast=Wang&rft.aufirst=M&rft.date=1995-11-01&rft.volume=26&rft.issue=5&rft.spage=836&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=02726386&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-12-05 N1 - Date created - 1995-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Non-Hodgkin's lymphoma associated with the acquired immunodeficiency syndrome. AN - 77904065; 8924158 AB - Patients with the Acquired Immunodeficiency Syndrome (AIDS) have an increased risk of developing Non-Hodgkin's Lymphomas (NHL). It is estimated that 8-27% of newly diagnosed NHL are associated with AIDS. The majority of these lymphomas are of intermediate or high grade histology. We retrospectively analyzed the clinical manifestations and response to different chemotherapy regimens in patients with AIDS NHL in the San Juan City and San Juan Veterans Administration Hospitals from 1990-1993. Eleven patients (10 M/1F) with an average age of 46 (range 31-68) were analyzed. 64% (7/11) of patients had a prior diagnosis of AIDS before the diagnosis of NHL. Pathology was diffuse large cell in 6, Burkitt's in 4 and immunoblastic in 1.73% of patients presented with Stage III/IV. Sites included gastrointestinal tract (2), skin/soft tissue (2), paranasal sinus (1), kidneys (1). The most common treatment regimen was the modified m-BACOD (64%). Complete response (CR) occurred in 46% (5/11) and partial response (PR) in 27% (3/11). 36% of patients developed opportunistic or bacterial infections during treatment. Median survival was 8 months. Two patients are long-time survivors at 24+, 29+ without evidence of NHL at present. This group of patients demonstrate the usual characteristics of NHL in AIDS patients and corroborate that conventional chemotherapy programs are only moderately effective in these patients. It is clear from this data and from other reports that further work will be required to ascertain optimal therapy for the patient with AIDS-related Non-Hodgkin's Lymphoma. JF - Boletin de la Asociacion Medica de Puerto Rico AU - Cáceres, W AD - Department of Hematology-Oncology, San Juan Veterans Administration Hospital, Puerto Rico, USA. PY - 1995 SP - 158 EP - 161 VL - 87 IS - 10-12 SN - 0004-4849, 0004-4849 KW - Bleomycin KW - 11056-06-7 KW - Vincristine KW - 5J49Q6B70F KW - Dexamethasone KW - 7S5I7G3JQL KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Leucovorin KW - Q573I9DVLP KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - AIDS/HIV KW - Humans KW - Retrospective Studies KW - Aged KW - Skin Neoplasms -- complications KW - Lymphoma, Large B-Cell, Diffuse -- complications KW - Cyclophosphamide -- therapeutic use KW - Vincristine -- therapeutic use KW - Adult KW - Paranasal Sinus Neoplasms -- complications KW - Kidney Neoplasms -- complications KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Bleomycin -- therapeutic use KW - Time Factors KW - Male KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- complications KW - Dexamethasone -- therapeutic use KW - Soft Tissue Neoplasms -- complications KW - Gastrointestinal Neoplasms -- complications KW - Survival Rate KW - Burkitt Lymphoma -- complications KW - Methotrexate -- therapeutic use KW - Doxorubicin -- therapeutic use KW - Middle Aged KW - Female KW - Leucovorin -- therapeutic use KW - Lymphoma, Non-Hodgkin -- drug therapy KW - Acquired Immunodeficiency Syndrome -- complications KW - Lymphoma, Non-Hodgkin -- mortality KW - Lymphoma, Non-Hodgkin -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77904065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Boletin+de+la+Asociacion+Medica+de+Puerto+Rico&rft.atitle=Non-Hodgkin%27s+lymphoma+associated+with+the+acquired+immunodeficiency+syndrome.&rft.au=C%C3%A1ceres%2C+W&rft.aulast=C%C3%A1ceres&rft.aufirst=W&rft.date=1995-10-01&rft.volume=87&rft.issue=10-12&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Boletin+de+la+Asociacion+Medica+de+Puerto+Rico&rft.issn=00044849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-10-25 N1 - Date created - 1996-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of 96-hour infusion fluorouracil plus cisplatin in combination with alpha interferon for patients with advanced squamous cell carcinoma of the head and neck: a Southwest Oncology Group study. AN - 77862254; 8630903 AB - Recurrent cancer of the head and neck after primary therapy is almost always fatal. The combination of 5-fluorouracil (5-FU) and cisplatin is considered the best available therapy but complete response rates remain too low to affect survival. This study was designed to evaluate the complete response rate and toxicity of 5-FU, cisplatin, and alpha-interferon (alpha-IFN) in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). Fifty eligible patients with recurrent or metastatic SCCHN and no prior chemotherapy (40 men, 10 women; age range, 26-77 years; median, 59 years; 82% white; 88% had prior surgery and 92% had prior radiation therapy) were treated every 21 days with 96-hour infusion of 5-FU 1000 mg/m2/day; cisplatin 100 mg/m2, day 1; and alpha-IFN 5 x 10(6) units/day, days 1-4. One hundred fifty-seven courses of chemotherapy were administered, with a median of three courses. Thirty-seven patients experienced Grade 3 or 4 toxicity. Of the 17 patients with Grade 4 toxicity; 12 had hematologic toxicity, 3 stomatitis, and 2 vomiting. Two additional patients died of myelosuppression-related sepsis. Of the 50 patients, 3 (6%) achieved a complete response, five (10%) had a partial response, 3 (6%) had unconfirmed response (1 complete and 2 partial), 10 (20%) had stable disease, 17 (34%) progressed, and 12 (24%) were considered nonresponders owing to early death (6) or inadequate assessment (6). The median survival was 5 months. The complete response rate of patients with recurrent or metastatic SCCHN treated with 5-FU, cisplatin, and alpha-IFN does not appear to be superior to that observed for 5-FU and cisplatin. Alpha-interferon appears to augment hematologic and gastrointestinal toxicities associated with this combination. JF - Cancer AU - Hussain, M AU - Benedetti, J AU - Smith, R E AU - Rodriguez, G I AU - Schuller, D AU - Ensley, J AD - Veterans Administration Medical Center, Allen Park, Michigan, USA. Y1 - 1995/10/01/ PY - 1995 DA - 1995 Oct 01 SP - 1233 EP - 1237 VL - 76 IS - 7 SN - 0008-543X, 0008-543X KW - Immunologic Factors KW - 0 KW - Interferon-alpha KW - Recombinant Proteins KW - interferon alfa-2a KW - 47RRR83SK7 KW - Cisplatin KW - Q20Q21Q62J KW - Fluorouracil KW - U3P01618RT KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Drug Administration Schedule KW - Infusions, Intravenous KW - Combined Modality Therapy KW - Humans KW - Aged KW - Cisplatin -- administration & dosage KW - Fluorouracil -- administration & dosage KW - Fluorouracil -- adverse effects KW - Survival Rate KW - Adult KW - Middle Aged KW - Cisplatin -- adverse effects KW - Female KW - Male KW - Remission Induction KW - Interferon-alpha -- therapeutic use KW - Interferon-alpha -- adverse effects KW - Head and Neck Neoplasms -- therapy KW - Immunologic Factors -- therapeutic use KW - Carcinoma, Squamous Cell -- mortality KW - Head and Neck Neoplasms -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Head and Neck Neoplasms -- drug therapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Immunologic Factors -- adverse effects KW - Carcinoma, Squamous Cell -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77862254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Evaluation+of+96-hour+infusion+fluorouracil+plus+cisplatin+in+combination+with+alpha+interferon+for+patients+with+advanced+squamous+cell+carcinoma+of+the+head+and+neck%3A+a+Southwest+Oncology+Group+study.&rft.au=Hussain%2C+M%3BBenedetti%2C+J%3BSmith%2C+R+E%3BRodriguez%2C+G+I%3BSchuller%2C+D%3BEnsley%2C+J&rft.aulast=Hussain&rft.aufirst=M&rft.date=1995-10-01&rft.volume=76&rft.issue=7&rft.spage=1233&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-07-03 N1 - Date created - 1996-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toxic neuropathies. AN - 77787498; 8542042 AB - Current publications describe neurotoxic effects of metals, pharmaceutical products, and environmental, biological and experimental substances. Agents such as lead remain the object of new epidemiological methods to identify victims. The use of methylcobalamin to ameliorate acrylamide toxicity is being explored. Antiarrhythmic and antilipidemic drugs continue to be associated with neuropathic effects but appear to be amenable to adjustments in dosage. To help control the neurotoxic effects of the chemotherapeutic drugs taxol and cisplatin analogs of adrenocorticotropic hormone and neurotrophic factors are being used. A new immunosuppressant, FK 506, has replaced cyclosporin to facilitate organ transplantation, but unwanted effects, including peripheral neuropathy, have been documented in some patients. In experimental studies, FK 506 has been reported to accelerate the rate of nerve regeneration. Botulinum toxin for the treatment of localized spastic disorders is a useful therapy, but training and supervision has been recommended by the American Academy of Neurology. Experimental toxins, such as imminodipropionitrile, continue to provide useful insights into physiologic mechanisms, including the axonal transport of cytoskeletal components. JF - Current opinion in neurology AU - Mizisin, A P AU - Powell, H C AD - Veterans Administration Medical Center, San Diego, California, USA. Y1 - 1995/10// PY - 1995 DA - October 1995 SP - 367 EP - 371 VL - 8 IS - 5 SN - 1350-7540, 1350-7540 KW - Environmental Pollutants KW - 0 KW - Neurotoxins KW - Index Medicus KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Neurotoxins -- adverse effects KW - Environmental Pollutants -- adverse effects KW - Peripheral Nervous System Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77787498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+neurology&rft.atitle=Toxic+neuropathies.&rft.au=Mizisin%2C+A+P%3BPowell%2C+H+C&rft.aulast=Mizisin&rft.aufirst=A&rft.date=1995-10-01&rft.volume=8&rft.issue=5&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+neurology&rft.issn=13507540&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-02-14 N1 - Date created - 1996-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Patient perceptions of self-induced water intoxication. AN - 77583900; 7487171 AB - This study comprehensively examines self-induced water intoxication (SIWI) from a patient perspective including demographics, reasons for seeking fluids, patterns/behaviors of fluid seeking, and symptoms frequently experienced while in a state of SIWI. The subjects were 45 of an original convenience sample of 62 individuals with a serious mental illness (SMI), hospitalized in a long-term state psychiatric facility, who engaged in self-induced water intoxication. All participants were interviewed in a structured format to complete a 40-item Likert-type questionnaire developed for the study, titled the Self-induced Water Intoxication Questionnaire (SIWIQ). In the study, the majority of participants were smokers, and reported no past problem with alcohol. SIWI occurred more in males than females, and was more predominant in those participants who had longer hospital stays. Anger and vomiting were found to be the two most predominant symptoms experienced when excess fluid consumption occurred. Behaviors of drinking from the shower, the toilet, and one's own urine are consistent with findings of previous studies and illustrate the difficulty in keeping individuals with SIWI from fluids. Data show that participants with SIWI experience considerable anxiety and cognitive difficulties and express these as reasons for engaging in excess fluid consumption. Boredom, obtaining a high, and sad mood were also predominant reasons identified for excess fluid drinking. Significant relationships were found and discussed. The findings provide support for the position that SIWI represents an attempt at treatment by the dysfunctional individual and is pursued for anxiolytic effects and alleviation of boredom. The data support the idea of approaching the problem from a dysfunctional coping framework, realizing that SIWI is a very complex problem, needing examination and intervention at multiple levels, beyond exclusive focus on fluid control. JF - Archives of psychiatric nursing AU - May, D L AD - Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA. Y1 - 1995/10// PY - 1995 DA - October 1995 SP - 295 EP - 304 VL - 9 IS - 5 SN - 0883-9417, 0883-9417 KW - Index Medicus KW - Nursing KW - Interview, Psychological KW - Length of Stay KW - Adaptation, Psychological KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Pilot Projects KW - Middle Aged KW - Sex Distribution KW - Male KW - Female KW - Self-Injurious Behavior -- psychology KW - Motivation KW - Attitude to Health KW - Water Intoxication -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77583900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+psychiatric+nursing&rft.atitle=Patient+perceptions+of+self-induced+water+intoxication.&rft.au=May%2C+D+L&rft.aulast=May&rft.aufirst=D&rft.date=1995-10-01&rft.volume=9&rft.issue=5&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Archives+of+psychiatric+nursing&rft.issn=08839417&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-12-08 N1 - Date created - 1995-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparative responsiveness of HL-60, HL-60R, and HL-60R+ (LRARSN) cells to retinoic acid, calcitriol, 9 cis-retinoic acid, and sodium butyrate. AN - 77497975; 7670094 AB - In HL-60 cells, retinoic acid (RA) and 9 cis-RA induce granulocytic differentiation, and calcitriol and sodium butyrate induce monocytic differentiation. To study the role of retinoid resistance on the response to these agents, we investigated their effects in HL-60 cells, retinoid-resistant HL-60R cells, and HL-60R+ cells in which retinoid sensitivity has been restored. In HL-60 cells, cathepsin D (ctsd) mRNA levels are increased by these agents and by cholera toxin after pretreatment with each agent. Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA). Pretreatment of HL-60 cells with all of the agents confers inducibility of cathepsin L (ctsl) mRNA by TPA in previously unresponsive cells. In HL-60R cells, none of the agents alone or in combination significantly enhances the expression of the ctsd, IL-8, or ctsl mRNAs. Retinoid stimulation (either alone or in combination with the other agents) of the three mRNAs is partially restored in the HL-60R+ cells. Calcitriol does not alter the expression of any of these mRNAs, and only the stimulation of IL-8 mRNA by sodium butyrate is recovered. Treatment with all of the agents inhibits proliferation and stimulates differentiation of the HL-60 cells. RA and calcitriol are unable to inhibit proliferation of the HL-60R cells, whereas only calcitriol fails to inhibit proliferation of the HL-60R+ cells. None of the agents induces differentiation in either the HL-60R or HL-60R+ cells. Therefore, the mutation of the RA receptor alpha is insufficient to account for the altered responses of the HL-60R cells, and there are likely defects in other signaling pathways in these cells. These cells may prove useful in examining the mechanism of cross-resistance between various differentiating agents. JF - Blood AU - Atkins, K B AU - Troen, B R AD - Department of Internal Medicine, Veterans Administration Medical Center, Ann Arbor, MI, USA. Y1 - 1995/10/01/ PY - 1995 DA - 1995 Oct 01 SP - 2475 EP - 2480 VL - 86 IS - 7 SN - 0006-4971, 0006-4971 KW - Butyrates KW - 0 KW - Interleukin-8 KW - RNA, Messenger KW - Butyric Acid KW - 107-92-6 KW - Tretinoin KW - 5688UTC01R KW - Cathepsins KW - EC 3.4.- KW - Endopeptidases KW - Cysteine Endopeptidases KW - EC 3.4.22.- KW - CTSL1 protein, human KW - EC 3.4.22.15 KW - Cathepsin L KW - Cathepsin D KW - EC 3.4.23.5 KW - Calcitriol KW - FXC9231JVH KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Cathepsin D -- genetics KW - Gene Expression -- drug effects KW - Humans KW - Drug Resistance KW - Cathepsins -- genetics KW - Tumor Cells, Cultured KW - RNA, Messenger -- metabolism KW - Interleukin-8 -- genetics KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Differentiation -- drug effects KW - Tretinoin -- pharmacology KW - Butyrates -- pharmacology KW - Leukemia, Promyelocytic, Acute -- metabolism KW - Leukemia, Promyelocytic, Acute -- pathology KW - Calcitriol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77497975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Comparative+responsiveness+of+HL-60%2C+HL-60R%2C+and+HL-60R%2B+%28LRARSN%29+cells+to+retinoic+acid%2C+calcitriol%2C+9+cis-retinoic+acid%2C+and+sodium+butyrate.&rft.au=Atkins%2C+K+B%3BTroen%2C+B+R&rft.aulast=Atkins&rft.aufirst=K&rft.date=1995-10-01&rft.volume=86&rft.issue=7&rft.spage=2475&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-10-19 N1 - Date created - 1995-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Motor and mental aspects of extrapyramidal syndromes. AN - 77940225; 8866772 AB - Neuroleptic-induced extrapyramidal syndromes (EPS) are major limitations to effective antipsychotic therapy. There are both motor (objective) and mental (subjective) components to EPS, which must be considered in the evaluation and differential diagnosis of treatment-related adverse events. In addition to causing motor impairment, these syndromes can also produce irritability, anxiousness and secondary negative symptoms of slow thinking and emotional blunting. The EPS of akathisia, dystonia, and parkinsonism have unique characteristics that are influenced by patient, drug and temporal aspects. With the advent of new and novel antipsychotic drugs that have low EPS liability, patients will have fewer side effects, be less non-compliant and more able to benefit from rehabilitation efforts. JF - International clinical psychopharmacology AU - Casey, D E AD - Veterans Administration Medical Center and Oregon Health Sciences University, Portland, USA. Y1 - 1995/09// PY - 1995 DA - September 1995 SP - 105 EP - 114 VL - 10 Suppl 3 SN - 0268-1315, 0268-1315 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Schizophrenic Psychology KW - Basal Ganglia Diseases -- diagnosis KW - Antipsychotic Agents -- pharmacology KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77940225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+clinical+psychopharmacology&rft.atitle=Motor+and+mental+aspects+of+extrapyramidal+syndromes.&rft.au=Casey%2C+D+E&rft.aulast=Casey&rft.aufirst=D&rft.date=1995-09-01&rft.volume=10+Suppl+3&rft.issue=&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=International+clinical+psychopharmacology&rft.issn=02681315&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-12-13 N1 - Date created - 1996-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethnicity and psychotherapy. A component in the treatment of cocaine addiction in African Americans. AN - 77689474; 8545270 AB - With a focus on the use of psychotherapy as a component in the comprehensive treatment of African Americans addicted to cocaine, this article reviews the literature on ethnicity and psychotherapy and discusses the main problems relevant to the planning of mental health and substance abuse services to minority populations in the United States. Some of the more salient areas are the relationship of cultural factors and substance abuse, the culturally determined possibilities and constraints in the treatment of substance abuse, the establishment of a culturally responsive psychotherapeutic approach that takes into account notions such as ethnic consciousness and self-esteem, and the therapist's effects on the proximal treatment situation. Research issues also are discussed, among them therapist-matching strategies, therapist's clinical skills, culturally responsive adaptations of psychotherapeutic frames and processes, and their effect on outcome. JF - The Psychiatric clinics of North America AU - Foulks, E F AU - Peña, J M AD - Veterans Administration Medical Center, New Orleans, Louisiana, USA. Y1 - 1995/09// PY - 1995 DA - September 1995 SP - 607 EP - 620 VL - 18 IS - 3 SN - 0193-953X, 0193-953X KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Self Concept KW - Humans KW - Substance-Related Disorders -- therapy KW - Culture KW - Psychotherapy KW - African Americans -- psychology KW - Ethnic Groups -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77689474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Psychiatric+clinics+of+North+America&rft.atitle=Ethnicity+and+psychotherapy.+A+component+in+the+treatment+of+cocaine+addiction+in+African+Americans.&rft.au=Foulks%2C+E+F%3BPe%C3%B1a%2C+J+M&rft.aulast=Foulks&rft.aufirst=E&rft.date=1995-09-01&rft.volume=18&rft.issue=3&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=The+Psychiatric+clinics+of+North+America&rft.issn=0193953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-02-14 N1 - Date created - 1996-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adenocarcinoma of the colon presenting as Streptococcus sanguis bacteremia. AN - 85226770; pmid-7639245 JF - The American Journal of Gastroenterology AU - Fass, R AU - Alim, A AU - Kaunitz, J D AD - Medical, Radiology, and Research Services, West Los Angeles Veterans Administration Medical Center, California, USA. PY - 1995 SP - 1343 EP - 1345 VL - 90 IS - 8 SN - 0002-9270, 0002-9270 KW - Streptococcal Infections KW - Human KW - Sigmoid Neoplasms KW - Aged KW - Bacteremia KW - Middle Age KW - Support, U.S. Gov't, Non-P.H.S. KW - Case Report KW - Adenocarcinoma KW - Colonic Neoplasms KW - Female KW - Streptococcus sanguis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85226770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Adenocarcinoma+of+the+colon+presenting+as+Streptococcus+sanguis+bacteremia.&rft.au=Fass%2C+R%3BAlim%2C+A%3BKaunitz%2C+J+D&rft.aulast=Fass&rft.aufirst=R&rft.date=1995-08-01&rft.volume=90&rft.issue=8&rft.spage=1343&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Malignant mesothelioma associated with low pulmonary tissue asbestos burdens: a light and scanning electron microscopic analysis of 18 cases. AN - 77587063; 8532693 AB - Most malignant mesothelioma cases are associated with pulmonary asbestos body (AB) counts significantly greater than those of the general population. However, the question remains whether malignant mesothelioma cases associated with "normal" AB counts (i.e., indistinguishable from the general population) represent background incidence levels or are, actually, asbestos related. We performed AB counts (by light microscopy) and mineral fiber analysis (by scanning electron microscopy) in 18 mesothelioma cases with AB counts within our normal range (0 to 20 AB/G wet lung) and in 19 "control" cases. Our study demonstrated that approximately one-third (6 of 18) of the mesothelioma cases have asbestos fiber burdens greater than 95% of the control levels. These results suggest that these six mesothelioma cases may be asbestos related despite AB counts similar to those of the general population. An asbestos etiology was suggested in three additional cases, but too few amphibole fibers were identified in these cases to be certain of a value above background. The remaining nine cases showed no evidence of an asbestos etiology. Electron microscopic analysis of pulmonary mineral fibers may be required to differentiate asbestos-related mesotheliomas from non-asbestos-related cases when AB counts are within the range of background values. JF - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc AU - Srebro, S H AU - Roggli, V L AU - Samsa, G P AD - Department of Pathology, Durham Veterans' Administration, North Carolina, USA. Y1 - 1995/08// PY - 1995 DA - August 1995 SP - 614 EP - 621 VL - 8 IS - 6 SN - 0893-3952, 0893-3952 KW - Mineral Fibers KW - 0 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Mineral Fibers -- analysis KW - Aged, 80 and over KW - Humans KW - Adult KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Microscopy, Electron, Scanning KW - Asbestos -- analysis KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- chemistry KW - Mesothelioma -- etiology KW - Lung -- chemistry KW - Mesothelioma -- pathology KW - Mesothelioma -- chemistry KW - Asbestos -- adverse effects KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77587063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Modern+pathology+%3A+an+official+journal+of+the+United+States+and+Canadian+Academy+of+Pathology%2C+Inc&rft.atitle=Malignant+mesothelioma+associated+with+low+pulmonary+tissue+asbestos+burdens%3A+a+light+and+scanning+electron+microscopic+analysis+of+18+cases.&rft.au=Srebro%2C+S+H%3BRoggli%2C+V+L%3BSamsa%2C+G+P&rft.aulast=Srebro&rft.aufirst=S&rft.date=1995-08-01&rft.volume=8&rft.issue=6&rft.spage=614&rft.isbn=&rft.btitle=&rft.title=Modern+pathology+%3A+an+official+journal+of+the+United+States+and+Canadian+Academy+of+Pathology%2C+Inc&rft.issn=08933952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-02-01 N1 - Date created - 1996-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aerobic inactivation of fumarate reductase from Escherichia coli by mutation of the [3Fe-4S]-quinone binding domain. AN - 77459134; 7642483 AB - Fumarate reductase from Escherichia coli functions both as an anaerobic fumarate reductase and as an aerobic succinate dehydrogenase. A site-directed mutation of E. coli fumarate reductase in which FrdB Pro-159 was replaced with a glutamine or histidine residue was constructed and overexpressed in a strain of E. coli lacking a functional copy of the fumarate reductase or succinate dehydrogenase complex. The consequences of these mutations on bacterial growth, assembly of the enzyme complex, and enzymatic activity were investigated. Both mutations were found to have no effect on anaerobic bacterial growth or on the ability of the enzyme to reduce fumarate compared with the wild-type enzyme. The FrdB Pro-159-to-histidine substitution was normal in its ability to oxidize succinate. In contrast, however, the FrdB Pro-159-to-Gln substitution was found to inhibit aerobic growth of E. coli under conditions requiring a functional succinate dehydrogenase, and furthermore, the aerobic activity of the enzyme was severely inhibited upon incubation in the presence of its substrate, succinate. This inactivation could be prevented by incubating the mutant enzyme complex in an anaerobic environment, separating the catalytic subunits of the fumarate reductase complex from their membrane anchors, or blocking the transfer of electrons from the enzyme to quinones. The results of these studies suggest that the succinate-induced inactivation occurs by the production of hydroxyl radicals generated by a Fenton-type reaction following introduction of this mutation into the [3Fe-4S] binding domain. Additional evidence shows that the substrate-induced inactivation requires quinones, which are the membrane-bound electron acceptors and donors for the succinate dehydrogenase and fumarate reductase activities. These data suggest that the [3Fe-4S] cluster is intimately associated with one of the quinone binding sites found n fumarate reductase and succinate dehydrogenase. JF - Journal of bacteriology AU - Cecchini, G AU - Sices, H AU - Schröder, I AU - Gunsalus, R P AD - Molecular Biology Division, Veterans Administration Medical Center, San Francisco, California 94121, USA. Y1 - 1995/08// PY - 1995 DA - August 1995 SP - 4587 EP - 4592 VL - 177 IS - 16 SN - 0021-9193, 0021-9193 KW - frdB KW - Bacterial Proteins KW - 0 KW - Iron-Sulfur Proteins KW - Membrane Proteins KW - Quinones KW - Succinate Dehydrogenase KW - EC 1.3.99.1 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Membrane Proteins -- metabolism KW - Membrane Proteins -- biosynthesis KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Membrane Proteins -- genetics KW - Binding Sites -- genetics KW - Aerobiosis KW - Sequence Homology, Amino Acid KW - Anaerobiosis KW - Succinate Dehydrogenase -- genetics KW - Bacterial Proteins -- genetics KW - Escherichia coli -- metabolism KW - Bacterial Proteins -- biosynthesis KW - Bacterial Proteins -- metabolism KW - Iron-Sulfur Proteins -- biosynthesis KW - Iron-Sulfur Proteins -- genetics KW - Escherichia coli -- genetics KW - Escherichia coli -- enzymology KW - Quinones -- metabolism KW - Iron-Sulfur Proteins -- metabolism KW - Succinate Dehydrogenase -- biosynthesis KW - Succinate Dehydrogenase -- metabolism KW - Escherichia coli -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77459134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Aerobic+inactivation+of+fumarate+reductase+from+Escherichia+coli+by+mutation+of+the+%5B3Fe-4S%5D-quinone+binding+domain.&rft.au=Cecchini%2C+G%3BSices%2C+H%3BSchr%C3%B6der%2C+I%3BGunsalus%2C+R+P&rft.aulast=Cecchini&rft.aufirst=G&rft.date=1995-08-01&rft.volume=177&rft.issue=16&rft.spage=4587&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-09-18 N1 - Date created - 1995-09-18 N1 - Date revised - 2017-01-13 N1 - Gene symbol - frdB N1 - SuppNotes - Cited By: Arch Microbiol. 1990;154(4):386-93 [2244791] J Biol Chem. 1990 Sep 25;265(27):16330-6 [2168888] J Biol Chem. 1991 Jul 25;266(21):13572-9 [1856194] J Biol Chem. 1992 Feb 5;267(4):2474-9 [1370822] Biochemistry. 1992 Mar 17;31(10):2703-12 [1312345] Biochim Biophys Acta. 1992 Jun 19;1100(3):235-41 [1351746] Biochemistry. 1992 Sep 22;31(37):8947-53 [1390681] Curr Genet. 1992 Aug;22(2):117-21 [1423716] J Biol Chem. 1993 Jan 15;268(2):815-22 [8419359] Annu Rev Biochem. 1993;62:797-821 [8352601] Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10771-8 [7971961] J Bacteriol. 1994 Dec;176(24):7653-8 [8002590] Eur J Biochem. 1972 Mar 27;26(2):267-78 [4339950] J Biol Chem. 1973 Jun 10;248(11):3987-96 [4708097] Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 [271968] Biochim Biophys Acta. 1978 Oct 23;505(2):129-45 [363147] J Biol Chem. 1979 Sep 10;254(17):8590-3 [381310] Biochim Biophys Acta. 1981 Apr 28;668(2):277-89 [7225412] Biochem J. 1980 Dec 15;192(3):769-81 [6263261] J Gen Microbiol. 1981 Feb;122(2):171-9 [6274999] Eur J Biochem. 1982 Aug;126(1):211-6 [6751816] J Bacteriol. 1982 Dec;152(3):1126-31 [6754697] J Biol Chem. 1983 Jan 10;258(1):508-22 [6848518] Methods Enzymol. 1983;101:20-78 [6310323] Biochem J. 1984 Sep 1;222(2):519-34 [6383359] Biochem J. 1984 Oct 15;223(2):507-17 [6388571] J Biol Chem. 1986 Feb 5;261(4):1808-14 [3511050] Proc Natl Acad Sci U S A. 1986 Dec;83(23):8898-902 [3538014] J Bacteriol. 1987 Feb;169(2):864-73 [3027051] Biochemistry. 1987 Jun 30;26(13):3776-81 [2820475] Methods Enzymol. 1987;154:367-82 [3323813] FEBS Lett. 1988 May 23;232(2):298-302 [2837411] J Biol Chem. 1988 Oct 15;263(29):14732-8 [2844784] Arch Microbiol. 1988;150(5):499-503 [2849923] Arch Biochem Biophys. 1989 Jan;268(1):26-34 [2643383] J Biol Chem. 1989 Aug 15;264(23):13599-604 [2668268] Free Radic Res Commun. 1990;8(4-6):307-15 [2162312] Proc Natl Acad Sci U S A. 1990 Nov;87(22):8965-9 [2174169] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Patterns of care for and outcomes of Pneumocystis carinii pneumonia among persons with transfusion-acquired AIDS. AN - 77435654; 7631408 AB - The most common human immunodeficiency virus (HIV)-related cause of death in persons with transfusion-acquired (TA) AIDS has been Pneumocystis carinii pneumonia (PCP). While better treatment for PCP accounts for improved survival among HIV-infected homosexual or bisexual men, the extent to which others have benefitted from these developments is unknown. Patterns of PCP care among persons with TA-AIDS, intravenous drug users, and homosexual or bisexual men are compared. TA-AIDS patients were older (mean, 46 years vs. 48.5 torr vs. 41% of others, p 80% for others, p < 0.05), more likely to be intubated (22% vs. 9-13% of others, p < 0.05), and more likely to die in-hospital (26% vs. 13-22% of others, p < 0.05). After controlling for differences in severity of illness, insurance, age, and hospital characteristics, TA-AIDS patients were 45 percent as likely to have early PCP therapy (95% CI, 22%, 91%) as were persons in high-risk groups. For persons whose only risk factor was transfusion, recognition of the HIV infection and its complications appears to be problematic, which may help explain poorer outcomes in persons with HIV-related PCP. JF - Transfusion AU - Bennett, C L AU - Horner, R D AU - Aboulafia, D AU - Weinstein, R A AD - Division of Health Services Research, Lakeside Veterans Administration Hospital, USA. Y1 - 1995/08// PY - 1995 DA - August 1995 SP - 674 EP - 678 VL - 35 IS - 8 SN - 0041-1132, 0041-1132 KW - Index Medicus KW - AIDS/HIV KW - Regression Analysis KW - Sex Factors KW - Humans KW - Bisexuality KW - Continental Population Groups KW - Adult KW - Substance-Related Disorders KW - Middle Aged KW - Homosexuality KW - Time Factors KW - Male KW - Female KW - Multivariate Analysis KW - Acquired Immunodeficiency Syndrome -- therapy KW - Acquired Immunodeficiency Syndrome -- complications KW - Blood Transfusion -- adverse effects KW - Pneumonia, Pneumocystis -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77435654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Patterns+of+care+for+and+outcomes+of+Pneumocystis+carinii+pneumonia+among+persons+with+transfusion-acquired+AIDS.&rft.au=Bennett%2C+C+L%3BHorner%2C+R+D%3BAboulafia%2C+D%3BWeinstein%2C+R+A&rft.aulast=Bennett&rft.aufirst=C&rft.date=1995-08-01&rft.volume=35&rft.issue=8&rft.spage=674&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-09-05 N1 - Date created - 1995-09-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of heavy alcohol intake in the absence of liver disease on bone mass in black and white men. AN - 77427915; 7629250 AB - Previous studies have shown that bone mass is significantly decreased in chronic alcoholic white patients, especially those with evidence of liver involvement. However, liver disease is an independent risk factor for bone loss. In vitro studies have shown that alcohol has a direct effect on osteoblasts. The effects of chronic alcohol consumption on bone mass in the absence of liver disease are not known. In addition, the effect of alcohol on bone in black alcoholic subjects has not been examined previously. In the present study, we evaluated the effects of prolonged heavy alcohol intake on bone mass in both black (n = 21) and white (n = 19) male subjects without significant liver disease. Bone mineral density (BMD) of the lumbar spine and hip and various markers of bone metabolism in alcoholic subjects were compared with those in respective age-matched controls (n = 16 blacks and 14 whites). Mean values for BMD of the lumbar spine, total hip, and femoral neck were not significantly different between alcoholic subjects and their respective controls among either blacks or whites. In white subjects, age and duration of alcohol were noted to have significant independent effects on BMD, whereas in blacks, age was the only factor that significantly affected bone mass independently. In the absence of liver disease, prolonged heavy alcohol intake results in bone loss in white subjects. The skeleton of black subjects may be less affected by alcohol. JF - The Journal of clinical endocrinology and metabolism AU - Odvina, C V AU - Safi, I AU - Wojtowicz, C H AU - Barengolts, E I AU - Lathon, P AU - Skapars, A AU - Desai, P N AU - Kukreja, S C AD - Section of Endocrinology and Nuclear Medicine Service, Veterans Administration West Side Medical Center, Chicago, Illinois 60612, USA. Y1 - 1995/08// PY - 1995 DA - August 1995 SP - 2499 EP - 2503 VL - 80 IS - 8 SN - 0021-972X, 0021-972X KW - Biomarkers KW - 0 KW - Parathyroid Hormone KW - Serum Albumin KW - Osteocalcin KW - 104982-03-8 KW - Phosphorus KW - 27YLU75U4W KW - Testosterone KW - 3XMK78S47O KW - Luteinizing Hormone KW - 9002-67-9 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Calcifediol KW - P6YZ13C99Q KW - Bilirubin KW - RFM9X3LJ49 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Regression Analysis KW - Reference Values KW - Serum Albumin -- analysis KW - Humans KW - African Americans KW - Parathyroid Hormone -- blood KW - Alkaline Phosphatase -- blood KW - Femur KW - Osteocalcin -- blood KW - Phosphorus -- blood KW - Calcifediol -- blood KW - Testosterone -- blood KW - Adult KW - Cohort Studies KW - Bilirubin -- blood KW - Luteinizing Hormone -- blood KW - Pelvic Bones KW - Biomarkers -- blood KW - Male KW - Lumbar Vertebrae KW - European Continental Ancestry Group KW - Bone Density KW - Alcoholism -- physiopathology KW - African Continental Ancestry Group UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77427915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=Effect+of+heavy+alcohol+intake+in+the+absence+of+liver+disease+on+bone+mass+in+black+and+white+men.&rft.au=Odvina%2C+C+V%3BSafi%2C+I%3BWojtowicz%2C+C+H%3BBarengolts%2C+E+I%3BLathon%2C+P%3BSkapars%2C+A%3BDesai%2C+P+N%3BKukreja%2C+S+C&rft.aulast=Odvina&rft.aufirst=C&rft.date=1995-08-01&rft.volume=80&rft.issue=8&rft.spage=2499&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-09-07 N1 - Date created - 1995-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Observations on delta homeostasis, the one-stimulus model of NREM-REM alternation and the neurobiologic implications of experimental dream studies. AN - 77637452; 7546323 AB - We first review the concept of delta homeostasis as formulated in our 1974 model and as developed quantitatively by Borbely and colleagues in several versions of the two-process model. We illustrate difficulties in the application of this quantitative model to the negative delta rebound in the rat and we put forward additional evidence that the negative rebound is a pathological rather than a homeostatic response to sleep deprivation. We next review experiments on rats in which the waking metabolic rate of limbic structures was increased by blockade of the NMDA-gated cation channel with ketamine and MK-801. As predicted by the 1974 homeostatic model, NREM delta increased during subsequent sleep. However, it remains to be shown that this powerful effect is actually caused by the metabolic change and that it is an intensification of physiological sleep rather than a non-specific increase in EEG slow waves caused by neurotoxicity. We then outline our one-stimulus model of NREM/REM alternation. In this model NREM sleep is induced by periodic (neuroendocrine?) pulses. These pulses increase delta EEG amplitude and density, depress arousal level and inhibit neural activity. When the strength of the pulsatile stimulus falls below a critical level, REM emerges as neuronal escape. Last, we discuss the neurobiologic implications of two robust findings in experimental dream studies: the relation of dream reports to arousal and the consistent failure of controlled studies to demonstrate qualitative differences between NREM and REM mentation. JF - Behavioural brain research AU - Feinberg, I AU - March, J D AD - Veterans Administration, Northern California System of Clinics, University of California at Davis 95616, USA. PY - 1995 SP - 97 EP - 108 VL - 69 IS - 1-2 SN - 0166-4328, 0166-4328 KW - Index Medicus KW - Rats KW - Animals KW - Humans KW - Brain Chemistry -- physiology KW - Sleep, REM -- physiology KW - Delta Rhythm KW - Homeostasis -- physiology KW - Dreams -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77637452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+brain+research&rft.atitle=Observations+on+delta+homeostasis%2C+the+one-stimulus+model+of+NREM-REM+alternation+and+the+neurobiologic+implications+of+experimental+dream+studies.&rft.au=Feinberg%2C+I%3BMarch%2C+J+D&rft.aulast=Feinberg&rft.aufirst=I&rft.date=1995-07-01&rft.volume=69&rft.issue=1-2&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Behavioural+brain+research&rft.issn=01664328&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-11-22 N1 - Date created - 1995-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13. AN - 77384456; 7607664 AB - It has been previously shown that some toxic effects of high concentrations of glucose are mediated by the hexosamine biosynthesis pathway and its rate-limiting enzyme glutamine:fructose-6-phosphate amidotransferase (GFA). We have used the cloned human GFA cDNA to study the chromosomal localization of the gene and tissue distribution of mRNA. The human GFA gene is on chromosome 2, band p13 as determined by fluorescence in situ hybridization. An 8-kb species of GFA mRNA was detected in all rat tissues tested with relatively high expression in testis and smooth muscle; a unique 3-kb mRNA species was found only in testis. JF - Human genetics AU - Zhou, J AU - Neidigh, J L AU - Espinosa, R AU - LeBeau, M M AU - McClain, D A AD - Veterans Administration Medical Center, Jackson, MS 39216, USA. Y1 - 1995/07// PY - 1995 DA - July 1995 SP - 99 EP - 101 VL - 96 IS - 1 SN - 0340-6717, 0340-6717 KW - RNA, Messenger KW - 0 KW - Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) KW - EC 2.6.1.16 KW - Index Medicus KW - Rats KW - Animals KW - In Situ Hybridization KW - Gene Expression -- genetics KW - Humans KW - Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) -- genetics KW - RNA, Messenger -- genetics KW - Chromosomes, Human, Pair 2 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77384456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+genetics&rft.atitle=Human+glutamine%3A+fructose-6-phosphate+amidotransferase%3A+characterization+of+mRNA+and+chromosomal+assignment+to+2p13.&rft.au=Zhou%2C+J%3BNeidigh%2C+J+L%3BEspinosa%2C+R%3BLeBeau%2C+M+M%3BMcClain%2C+D+A&rft.aulast=Zhou&rft.aufirst=J&rft.date=1995-07-01&rft.volume=96&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Human+genetics&rft.issn=03406717&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-08-17 N1 - Date created - 1995-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phorbol ester stimulated cathepsin L expression in U937 cells. AN - 77502512; 7669726 AB - Cathepsin L (ctsl) is a lysosomal cysteine proteinase, the synthesis and secretion of which is induced by transformation, growth factors, and tumor promoters. We studied the effect and the mechanism of action of phorbol ester (TPA) on the expression of ctsl mRNA in U937 histiocytic leukemia cells. TPA treatment induces ctsl mRNA in a manner that is dose-dependent, occurs at the level of transcription, and is ablated by cotreatment with cycloheximide but is unaffected by dexamethasone. Treatment with TPA plus staurosporine, a potent protein kinase C inhibitor, results in greater expression of ctsl mRNA than does treatment with TPA alone. Similar to TPA, staurosporine alone increases ctsl transcription, an effect that is inhibited by cycloheximide. Another PKC inhibitor, H7, exerted no effect upon the induction of ctsl mRNA by either TPA or staurosporine. Staurosporine and H7, however, inhibit the increase in c-jun mRNA by TPA. In contrast, the tyrosine kinase inhibitors herbimycin A and genistein inhibit the effect of TPA and staurosporine upon ctsl mRNA with little or no effect on c-jun expression. Pretreatment with sodium orthovanadate enhances the induction of ctsl expression by TPA and staurosporine. These data suggest that, in U937 cells, TPA-stimulated ctsl gene transcription is apparently activated by a protein kinase C-independent signal transduction pathway involving tyrosine kinase activation. JF - Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research AU - Atkins, K B AU - Troen, B R AD - Department of Internal Medicine, Veterans Administration Medical Center, University of Michigan, Ann Arbor 48109, USA. Y1 - 1995/06// PY - 1995 DA - June 1995 SP - 713 EP - 718 VL - 6 IS - 6 SN - 1044-9523, 1044-9523 KW - c-fos KW - c-jun KW - ctsL KW - Alkaloids KW - 0 KW - Isoquinolines KW - Neoplasm Proteins KW - Piperazines KW - Vanadates KW - 3WHH0066W5 KW - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine KW - 84477-87-2 KW - Cycloheximide KW - 98600C0908 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Cathepsins KW - EC 3.4.- KW - Endopeptidases KW - Cysteine Endopeptidases KW - EC 3.4.22.- KW - CTSL1 protein, human KW - EC 3.4.22.15 KW - Cathepsin L KW - Staurosporine KW - H88EPA0A3N KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Neoplasm Proteins -- biosynthesis KW - Drug Interactions KW - Vanadates -- pharmacology KW - Humans KW - Piperazines -- pharmacology KW - Isoquinolines -- pharmacology KW - Protein Kinase C -- antagonists & inhibitors KW - Tumor Cells, Cultured KW - Enzyme Induction -- drug effects KW - Cycloheximide -- pharmacology KW - Neoplasm Proteins -- genetics KW - Alkaloids -- pharmacology KW - Cell Differentiation -- drug effects KW - Cathepsins -- genetics KW - Cathepsins -- biosynthesis KW - Lymphoma, Large B-Cell, Diffuse -- pathology KW - Monocytes -- enzymology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Monocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77502512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+growth+%26+differentiation+%3A+the+molecular+biology+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Phorbol+ester+stimulated+cathepsin+L+expression+in+U937+cells.&rft.au=Atkins%2C+K+B%3BTroen%2C+B+R&rft.aulast=Atkins&rft.aufirst=K&rft.date=1995-06-01&rft.volume=6&rft.issue=6&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Cell+growth+%26+differentiation+%3A+the+molecular+biology+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10449523&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-10-19 N1 - Date created - 1995-10-19 N1 - Date revised - 2017-01-13 N1 - Gene symbol - c-fos; c-jun; ctsL N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Malignant mesothelioma and duration of asbestos exposure: correlation with tissue mineral fibre content. AN - 77354207; 7793754 AB - Among 441 cases of malignant mesothelioma in the author's files, there were 324 for whom reliable information was available regarding the duration of exposure to asbestos. Included were 298 pleural and 26 peritoneal mesotheliomas. The mean duration of exposure to asbestos was 23 +/- 14 years for all cases, and was not different for the pleural and peritoneal groups. Lung tissue was available for analysis of mineral fibre content in 94 cases. Linear regression analysis showed a significant correlation between duration of exposure and asbestos bodies per gramme of wet lung as determined by light microscopy, and between duration of exposure and total uncoated fibres (5 microns or greater in length) as well as commercial amphibole fibres per gramme as determined by scanning electron microscopy (P < 0.05). Individuals with direct exposures had on average higher asbestos contents than patients with indirect exposures. Furthermore, for each duration of exposure, shipyard workers had on average higher asbestos contents than non-shipyard workers (P < 0.05). Mesotheliomas are associated with a wide range of durations of exposure to asbestos and pulmonary asbestos burdens, and there is a rough correlation between duration of exposure and pulmonary commercial amphibole content. JF - The Annals of occupational hygiene AU - Roggli, V L AD - Department of Pathology, Durham Veterans Administration, NC 27710, USA. Y1 - 1995/06// PY - 1995 DA - June 1995 SP - 363 EP - 374 VL - 39 IS - 3 SN - 0003-4878, 0003-4878 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Adult KW - Lung -- ultrastructure KW - Aged KW - Middle Aged KW - Time Factors KW - Male KW - Female KW - Asbestos -- analysis KW - Mesothelioma -- etiology KW - Occupational Exposure -- adverse effects KW - Asbestos -- adverse effects KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77354207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Malignant+mesothelioma+and+duration+of+asbestos+exposure%3A+correlation+with+tissue+mineral+fibre+content.&rft.au=Roggli%2C+V+L&rft.aulast=Roggli&rft.aufirst=V&rft.date=1995-06-01&rft.volume=39&rft.issue=3&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-07-25 N1 - Date created - 1995-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulation of endothelial cell gap formation and barrier dysfunction: role of myosin light chain phosphorylation. AN - 77324408; 7775594 AB - Endothelial cell (EC) contraction results in intercellular gap formation and loss of the selective vascular barrier to circulating macromolecules. We tested the hypothesis that phosphorylation of regulatory myosin light chains (MLC) by Ca2+/calmodulin-dependent myosin light chain kinase (MLCK) is critical to EC barrier dysfunction elicited by thrombin. Thrombin stimulated a rapid (< 15 sec) increase in [Ca2+]i which preceded maximal MLC phosphorylation (60 sec) with a 6 to 8-fold increase above constitutive levels of phosphorylated MLC. Dramatic cellular shape changes indicative of contraction and gap formation were observed at 5 min with maximal increases in albumin permeability occurring by 10 min. Neither the Ca2+ ionophore, A23187, nor phorbol myristate acetate (PMA), a direct activator of protein kinase C (PKC), alone or in combination, produced MLC phosphorylation. The combination was synergistic, however, in stimulating EC contraction/gap formation and barrier dysfunction (3 to 4-fold increase). Down-regulation or inhibition of PKC activity attenuated thrombin-induced MLC phosphorylation (approximately 40% inhibition) and both thrombin- and PMA-induced albumin clearance (approximately 50% inhibition). Agents which augmented [cAMP]i partially blocked thrombin-induced MLC phosphorylation (approximately 50%) and completely inhibited both thrombin- and PMA-induced EC permeability (100% inhibition). Furthermore, cAMP produced significant reduction in the basal levels of constitutive MLC phosphorylation. Finally, MLCK inhibition (with either ML-7 or KT 5926) or Ca2+/calmodulin antagonism (with either trifluoperazine or W-7) attenuated thrombin-induced MLC phosphorylation and barrier dysfunction. These results suggest a model wherein EC contractile events, gap formation and barrier dysfunction occur via MLCK-dependent and independent mechanisms and are significantly modulated by both PKC and cAMP-dependent protein kinase A activities. JF - Journal of cellular physiology AU - Garcia, J G AU - Davis, H W AU - Patterson, C E AD - Department of Medicine, Indiana University School of Medicine, Richard L. Roudebush, Veterans Administration Medical Center, Indianapolis 46202, USA. Y1 - 1995/06// PY - 1995 DA - June 1995 SP - 510 EP - 522 VL - 163 IS - 3 SN - 0021-9541, 0021-9541 KW - Calmodulin KW - 0 KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Thrombin KW - EC 3.4.21.5 KW - Myosins KW - EC 3.6.4.1 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Calcium -- metabolism KW - Animals KW - Protein Kinase C -- antagonists & inhibitors KW - Cattle KW - Phosphorylation KW - Cells, Cultured KW - Humans KW - Calmodulin -- physiology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Intracellular Membranes -- metabolism KW - Cyclic AMP-Dependent Protein Kinases -- pharmacology KW - Biological Transport -- drug effects KW - Myosins -- metabolism KW - Gap Junctions -- physiology KW - Endothelium, Vascular -- cytology KW - Thrombin -- pharmacology KW - Capillary Permeability -- drug effects KW - Endothelium, Vascular -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77324408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=Regulation+of+endothelial+cell+gap+formation+and+barrier+dysfunction%3A+role+of+myosin+light+chain+phosphorylation.&rft.au=Garcia%2C+J+G%3BDavis%2C+H+W%3BPatterson%2C+C+E&rft.aulast=Garcia&rft.aufirst=J&rft.date=1995-06-01&rft.volume=163&rft.issue=3&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=00219541&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-07-11 N1 - Date created - 1995-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparative Conflict Resolution Patterns among Parent-Teen Dyads of Four Ethnic Groups in Hawaii AN - 61384580; 9514402 AB - High school students (N = 96) in HI reported their own behavior & the behavior of their parents in the resolution of conflicts during the previous year, using the Conflict Tactics Scale. Parent-teen dyadic aggression levels for Americans of European, Japanese, Polynesian, & Filipino ancestry were compared in a series of orthogonal contrasts. The adolescent children of Polynesian-American parents reported significantly higher parent aggression levels than did adolescents with parents of other ethnicity. Parent aggression was the best predictor of teen aggression directed toward parents. Ss reciprocated with counteraggression toward European-American parents significantly more often than toward parents of other ethnicity. Aggression by one parent was highly correlated with aggression by the other parent. Aggression by either parent was more highly correlated with teen aggression toward the mother, vs toward the father. 6 Tables, 39 References. Adapted from the source document. JF - Child Abuse and Neglect AU - Hartz, Diane T AD - Psychiatry Service Veterans Administration Medical Center, 4150 Clement St San Francisco CA 94121 Y1 - 1995/06// PY - 1995 DA - June 1995 SP - 681 EP - 689 VL - 19 IS - 6 SN - 0145-2134, 0145-2134 KW - conflict resolution, high school students/their parents, ethnic differences, Hawaii KW - scale KW - Ethnic Groups KW - Hawaii KW - Parent Child Relations KW - Aggression KW - Conflict Resolution KW - High School Students KW - Adolescents KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61384580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Abuse+and+Neglect&rft.atitle=Comparative+Conflict+Resolution+Patterns+among+Parent-Teen+Dyads+of+Four+Ethnic+Groups+in+Hawaii&rft.au=Hartz%2C+Diane+T&rft.aulast=Hartz&rft.aufirst=Diane&rft.date=1995-06-01&rft.volume=19&rft.issue=6&rft.spage=681&rft.isbn=&rft.btitle=&rft.title=Child+Abuse+and+Neglect&rft.issn=01452134&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - CABND3 N1 - SubjectsTermNotLitGenreText - Conflict Resolution; Hawaii; High School Students; Adolescents; Aggression; Parent Child Relations; Ethnic Groups ER - TY - JOUR T1 - Identification and mutational analysis of the glycosylation sites of human keratin 18. AN - 77264190; 7538124 AB - Keratin polypeptides 8 and 18 (K8/18) are intermediate filament phosphoglycoproteins that are expressed preferentially in glandular epithelia. We previously showed that K8/18 phosphorylation occurs on serine residues and that K8/18 glycosylation consists of O-linked single N-acetylglucosamines (O-GlcNAc) that are linked to Ser/Thr. Since the function of these modifications is unknown, we sought as a first step to identify the precise modification sites and asked if they play a role in keratin filament assembly. For this, we generated a panel of K18 Ser and Thr-->Ala mutants at potential glycosylation sites followed by expression in a baculovirus-insect cell system. We identified the major glycosylation sites of K18 by comparing the tryptic 3H-glycopeptide pattern of the panel of mutant and wild type K18 expressed in the insect cells with the glycopeptides of K18 in human colonic cells. The identified sites occur on three serines in the head domain of K18. The precise modified residues in human cells were verified using Edman degradation and confirmed further by the lack of glycosylation of a K18 construct that was mutated at the molecularly identified sites then transfected into NIH-3T3 cells. Partial or total K18 glycosylation mutants transfected into mammalian cells manifested nondistinguishable filament assembly to cells transfected with wild type K8/18. Our results show that K18 glycosylation sites share some features with other already identified O-GlcNAc sites and may together help predict glycosylation sites of other intermediate filament proteins. JF - The Journal of biological chemistry AU - Ku, N O AU - Omary, M B AD - Palo Alto Veterans Administration Medical Center, California 94304, USA. Y1 - 1995/05/19/ PY - 1995 DA - 1995 May 19 SP - 11820 EP - 11827 VL - 270 IS - 20 SN - 0021-9258, 0021-9258 KW - DNA, Complementary KW - 0 KW - Recombinant Fusion Proteins KW - Keratins KW - 68238-35-7 KW - Index Medicus KW - Recombinant Fusion Proteins -- metabolism KW - Mutagenesis, Site-Directed KW - Nucleopolyhedrovirus KW - Animals KW - DNA, Complementary -- genetics KW - Spodoptera KW - Transfection KW - Humans KW - Molecular Sequence Data KW - Mice KW - Amino Acid Sequence KW - Glycosylation KW - Sequence Homology, Amino Acid KW - Cell Line KW - Cricetinae KW - Keratins -- metabolism KW - Keratins -- genetics KW - Protein Processing, Post-Translational UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77264190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Identification+and+mutational+analysis+of+the+glycosylation+sites+of+human+keratin+18.&rft.au=Ku%2C+N+O%3BOmary%2C+M+B&rft.aulast=Ku&rft.aufirst=N&rft.date=1995-05-19&rft.volume=270&rft.issue=20&rft.spage=11820&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-06-12 N1 - Date created - 1995-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationship of biopsy and final specimens in evaluation of tumor thickness in floor of mouth carcinoma. AN - 85192267; pmid-7760664 AB - A number of studies have suggested that tumor thickness may be a valuable prognostic indicator in the evaluation of head and neck cancers. This study examined the relationship between tumor thickness measured in preliminary biopsy specimens with the final specimens obtained in 31 patients with floor of mouth epidermoid carcinoma. There was a significant statistical correlation between biopsy and final specimens. The Pearson's product-moment correlation coefficient was 0.58, which corresponded to a significance level of P < .0005. The results of this study showed that those patients who had biopsies with a thickness less than or equal to 1 mm were likely to have final specimens with a thickness less than 2 mm. All patients with a thickness greater than 2 mm had a final specimen with a thickness greater than 3.5 mm. Modification of current biopsy techniques may result in values more predictive of final thickness measurements. JF - The Laryngoscope AU - Karas, D E AU - Baredes, S AU - Chen, T S AU - Karas, S F AD - Veterans Administration Medical Center, East Orange, NJ, USA. PY - 1995 SP - 491 EP - 493 VL - 105 IS - 5 Pt 1 SN - 0023-852X, 0023-852X KW - Human KW - Mouth Floor KW - Prognosis KW - Retrospective Studies KW - Middle Age KW - Biopsy KW - Predictive Value of Tests KW - Carcinoma, Squamous Cell KW - Mouth Neoplasms KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85192267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Relationship+of+biopsy+and+final+specimens+in+evaluation+of+tumor+thickness+in+floor+of+mouth+carcinoma.&rft.au=Karas%2C+D+E%3BBaredes%2C+S%3BChen%2C+T+S%3BKaras%2C+S+F&rft.aulast=Karas&rft.aufirst=D&rft.date=1995-05-01&rft.volume=105&rft.issue=5+Pt+1&rft.spage=491&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Role of glycosylation in the expression of human procathepsin D. AN - 77486084; 7657720 AB - Human procathepsin D carries two N-linked glycosylation sites at asparagine residues 70 and 199, widely separated on the surface of the folded protein. We created monoglycosylated procathepsin D molecules by site-directed mutagenesis in vitro of the individual glycosylation sites. With only two exceptions, all 12 mutants of this type were expressed efficiently in mammalian cells. The expressed proteins were stable, targeted to the lysosome, and partially secreted into the medium. When both glycosylation sites were eliminated, however, the expressed proteins (9 different mutants) were stable but most were not secreted and targeted poorly to the lysosome. Mammalian fibroblasts appear to sort nascent procathepsin D efficiently only if it is N-glycosylated. Procathepsin D monoglycosylated at N70 is readily distinguished from the endogenous protein in transfected human cells and thus provides an excellent substrate for studying lysosomal targeting in an homologous system. JF - Journal of cell science AU - Fortenberry, S C AU - Schorey, J S AU - Chirgwin, J M AD - Research Service, Audie L. Murphy Memorial Veterans Administration Hospital, San Antonio, Texas, USA. Y1 - 1995/05// PY - 1995 DA - May 1995 SP - 2001 EP - 2006 VL - 108 ( Pt 5) SN - 0021-9533, 0021-9533 KW - Ren-1 KW - Ren-2 KW - c-myc KW - grp78 KW - Carrier Proteins KW - 0 KW - DNA, Complementary KW - Enzyme Precursors KW - Heat-Shock Proteins KW - Molecular Chaperones KW - Proto-Oncogene Proteins c-myc KW - Recombinant Fusion Proteins KW - molecular chaperone GRP78 KW - procathepsin D KW - EC 3.4.23.- KW - Cathepsin D KW - EC 3.4.23.5 KW - Index Medicus KW - Animals KW - Molecular Chaperones -- genetics KW - Carrier Proteins -- metabolism KW - DNA, Complementary -- genetics KW - Molecular Chaperones -- metabolism KW - Cricetulus KW - Carrier Proteins -- genetics KW - Humans KW - Recombinant Fusion Proteins -- secretion KW - Proto-Oncogene Proteins c-myc -- genetics KW - Lysosomes -- metabolism KW - Proto-Oncogene Proteins c-myc -- metabolism KW - Glycosylation KW - Fibroblasts -- metabolism KW - Recombinant Fusion Proteins -- metabolism KW - Mutagenesis, Site-Directed KW - Fibroblasts -- secretion KW - Transfection KW - Cell Compartmentation KW - CHO Cells KW - Species Specificity KW - Cricetinae KW - Cathepsin D -- metabolism KW - Cathepsin D -- genetics KW - Enzyme Precursors -- metabolism KW - Cathepsin D -- secretion KW - Protein Processing, Post-Translational KW - Enzyme Precursors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77486084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cell+science&rft.atitle=Role+of+glycosylation+in+the+expression+of+human+procathepsin+D.&rft.au=Fortenberry%2C+S+C%3BSchorey%2C+J+S%3BChirgwin%2C+J+M&rft.aulast=Fortenberry&rft.aufirst=S&rft.date=1995-05-01&rft.volume=108+%28+Pt+5%29&rft.issue=&rft.spage=2001&rft.isbn=&rft.btitle=&rft.title=Journal+of+cell+science&rft.issn=00219533&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-10-02 N1 - Date created - 1995-10-02 N1 - Date revised - 2017-01-13 N1 - Gene symbol - Ren-1; Ren-2; c-myc; grp78 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Urges to smoke during the first month of abstinence: relationship to relapse and predictors. AN - 77481036; 7659764 AB - The urges to smoke reported by 215 former smokers were measured 1 day, 7 days, 14 days and 30 days after they quit to examine: (a) the time course of smoking urges, (b) the relationship of urges to relapse, and (c) predictors of urges to smoke. Urges to smoke were strongest 1 day after quitting, and decreased at each subsequent measurement point. Urges were a powerful predictor of relapse. At each of the four assessment points, abstinent subjects who reported stronger urges to smoke were more likely to relapse by the next measurement point. Urges to smoke at a given day (e.g., day 1) were consistently the best predictors of the persistence of urges at the next assessment (e.g., day 7). Greater negative emotion (e.g., anxiety, sadness, anger, and confusion) and psychosocial stress also predicted stronger urges to smoke. Nicotine gum significantly reduced urges during week 1 post-cessation. Clinical implications of the findings are discussed. JF - Psychopharmacology AU - Doherty, K AU - Kinnunen, T AU - Militello, F S AU - Garvey, A J AD - Harvard School of Dental Medicine and Normative Aging Study, Veterans Administration Outpatient Clinic, Boston, MA, USA. Y1 - 1995/05// PY - 1995 DA - May 1995 SP - 171 EP - 178 VL - 119 IS - 2 SN - 0033-3158, 0033-3158 KW - Coffee KW - 0 KW - Index Medicus KW - Emotions KW - Probability KW - Humans KW - Social Behavior KW - Alcohol Drinking KW - Recurrence KW - Adult KW - Cues KW - Tobacco Use Disorder -- psychology KW - Stress, Psychological -- diagnosis KW - Tobacco Use Disorder -- prevention & control KW - Follow-Up Studies KW - Middle Aged KW - Time Factors KW - Female KW - Male KW - Stress, Psychological -- psychology KW - Smoking Cessation KW - Smoking -- psychology KW - Smoking -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77481036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Urges+to+smoke+during+the+first+month+of+abstinence%3A+relationship+to+relapse+and+predictors.&rft.au=Doherty%2C+K%3BKinnunen%2C+T%3BMilitello%2C+F+S%3BGarvey%2C+A+J&rft.aulast=Doherty&rft.aufirst=K&rft.date=1995-05-01&rft.volume=119&rft.issue=2&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-10-03 N1 - Date created - 1995-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lysine residues in the C-terminal lobe and lysosomal targeting of procathepsin D. AN - 77480047; 7657721 AB - A major pathway to the lysosome for soluble hydrolases involves the 6-phosphorylation of mannose residues. The initial step in this reaction is catalyzed by a phosphotransferase which recognizes lysosomal precursors. We constructed mutants of human procathepsin D whose targeting to the lysosome could be assayed directly in intact cells. Eight lysine residues were individually converted to glutamic acid on the surface of the carboxyl terminal lobe of the protein. Mutants with as many as four Lys to Glu mutations were normally targeted to the lysosome and processed to the mature form of the enzyme in transfected cells. We conclude that the C-terminal lobe of procathepsin D may not carry a determinant essential for lysosomal targeting in intact fibroblasts. JF - Journal of cell science AU - Schorey, J S AU - Fortenberry, S C AU - Chirgwin, J M AD - Research Service, Audie L. Murphy Memorial Veterans Administration Hospital, San Antonio, Texas, USA. Y1 - 1995/05// PY - 1995 DA - May 1995 SP - 2007 EP - 2015 VL - 108 ( Pt 5) SN - 0021-9533, 0021-9533 KW - Enzyme Precursors KW - 0 KW - Mannosephosphates KW - Proto-Oncogene Proteins c-myc KW - Recombinant Fusion Proteins KW - mannose-6-phosphate KW - 3672-15-9 KW - Phosphotransferases KW - EC 2.7.- KW - procathepsin D KW - EC 3.4.23.- KW - Renin KW - EC 3.4.23.15 KW - Cathepsin D KW - EC 3.4.23.5 KW - Lysine KW - K3Z4F929H6 KW - Index Medicus KW - Animals KW - Proto-Oncogene Proteins c-myc -- immunology KW - Cricetulus KW - Humans KW - Biological Transport KW - Proto-Oncogene Proteins c-myc -- genetics KW - Glycosylation KW - Phosphotransferases -- metabolism KW - Mutagenesis, Site-Directed KW - Renin -- metabolism KW - Phosphorylation KW - Cercopithecus aethiops KW - CHO Cells KW - Cell Line, Transformed KW - Mannosephosphates -- metabolism KW - Species Specificity KW - Female KW - Cricetinae KW - Recombinant Fusion Proteins -- metabolism KW - Cathepsin D -- metabolism KW - Cathepsin D -- genetics KW - Enzyme Precursors -- metabolism KW - Protein Processing, Post-Translational KW - Enzyme Precursors -- chemistry KW - Lysosomes -- metabolism KW - Cathepsin D -- chemistry KW - Protein Structure, Tertiary KW - Enzyme Precursors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77480047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cell+science&rft.atitle=Lysine+residues+in+the+C-terminal+lobe+and+lysosomal+targeting+of+procathepsin+D.&rft.au=Schorey%2C+J+S%3BFortenberry%2C+S+C%3BChirgwin%2C+J+M&rft.aulast=Schorey&rft.aufirst=J&rft.date=1995-05-01&rft.volume=108+%28+Pt+5%29&rft.issue=&rft.spage=2007&rft.isbn=&rft.btitle=&rft.title=Journal+of+cell+science&rft.issn=00219533&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-10-02 N1 - Date created - 1995-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aggravation of gastric mucosal lesions in rat stomach by tobacco cigarette smoke. AN - 77240075; 7729274 AB - In the model of gastric mucosal injury induced by 2 mol/liter hypertonic saline in rats, we tested the hypothesis that tobacco cigarette smoke aggravates gastric mucosal lesions by inhibition of injury-induced gastric mucosal hyperemia. Experimental rats were treated with tobacco cigarette smoke or nicotine-free smoke from nontobacco cigarettes, and controls breathed room air. Gastric mucosal blood flow was measured by hydrogen gas clearance before and during the intragastric administration of hypertonic saline. Tobacco cigarette smoke 3 and 18 ml/min, but not nicotine-free smoke, significantly attenuated the hyperemia and aggravated the hypertonic saline-induced lesion in a dose-dependent manner. We then tested the hypothesis that 18 ml/min of tobacco cigarette smoke, and the dose of intravenous nicotine previously shown to block injury-induced hyperemia and aggravate 2 mol/liter saline-induced gastric damage, will also adversely affect gastric lesions induced by acidified aspirin or acidified ethanol. The results confirm that tobacco cigarette smoke and intravenous nicotine indeed aggravate gastric mucosal damage in these two models. Taken together, the data suggest that the inhibition of injury-induced hyperemia by nicotine and tobacco cigarette smoke is an important predictor of their ability to increase the susceptibility of the gastric mucosa to noxious damage. Although limited in their experimental nature, these data provide one plausible explanation for the adverse effect of tobacco cigarette smoke on peptic ulcer disease. JF - Digestive diseases and sciences AU - Iwata, F AU - Zhang, X Y AU - Leung, F W AD - Research Service, Sepulveda Veterans Administration Medical Center, California 91343, USA. Y1 - 1995/05// PY - 1995 DA - May 1995 SP - 1118 EP - 1124 VL - 40 IS - 5 SN - 0163-2116, 0163-2116 KW - Smoke KW - 0 KW - Ethanol KW - 3K9958V90M KW - Sodium Chloride KW - 451W47IQ8X KW - Nicotine KW - 6M3C89ZY6R KW - Hydrogen KW - 7YNJ3PO35Z KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Ethanol -- adverse effects KW - Animals KW - Rats, Sprague-Dawley KW - Sodium Chloride -- adverse effects KW - Aspirin -- adverse effects KW - Nicotine -- pharmacology KW - Time Factors KW - Male KW - Plants, Toxic KW - Tobacco KW - Gastric Mucosa -- blood supply KW - Gastric Mucosa -- drug effects KW - Hyperemia -- physiopathology KW - Gastric Mucosa -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77240075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Aggravation+of+gastric+mucosal+lesions+in+rat+stomach+by+tobacco+cigarette+smoke.&rft.au=Iwata%2C+F%3BZhang%2C+X+Y%3BLeung%2C+F+W&rft.aulast=Iwata&rft.aufirst=F&rft.date=1995-05-01&rft.volume=40&rft.issue=5&rft.spage=1118&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-06-01 N1 - Date created - 1995-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cobras. AN - 77085234; 11995909 AB - Human encounters with cobras in Africa and Asia are common with substantial mortality and primarily respiratory paralysis in untreated cases. First aid includes maintaining calm, placing a lymphatic retardant on the bitten extremity, and transportation to a medical facility. Medical management is antivenin. Physiologic monitoring and the ability to manage the compromised airway are important. JF - Wilderness & environmental medicine AU - Davidson, T M AU - Schafer, S AU - Killfoil, J AD - Division of Otolartngology-Head and Neck Surgery, University of California Medical Center and Veterans Administration Medical Center, San Diego 92103-8895, USA. Y1 - 1995/05// PY - 1995 DA - May 1995 SP - 203 EP - 219 VL - 6 IS - 2 SN - 1080-6032, 1080-6032 KW - Antivenins KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Adult KW - Child KW - First Aid -- methods KW - Antivenins -- therapeutic use KW - Snake Bites -- diagnosis KW - Snake Bites -- therapy KW - Elapidae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77085234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wilderness+%26+environmental+medicine&rft.atitle=Cobras.&rft.au=Davidson%2C+T+M%3BSchafer%2C+S%3BKillfoil%2C+J&rft.aulast=Davidson&rft.aufirst=T&rft.date=1995-05-01&rft.volume=6&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Wilderness+%26+environmental+medicine&rft.issn=10806032&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-05 N1 - Date created - 2002-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Racial Differences in Rural Adults' Views on Adolescent Sexuality -- Revisited AN - 61411989; 9514357 AB - A randomly selected sample of 191 white & black adults from a rural NC county were surveyed about adolescent health & sexuality issues following a 3-year, community-wide adolescent health promotion campaign. These results are compared to findings of a survey conducted prior to the campaign (N = 835 adults). Analysis suggests that the campaign had little effect on Ss' attitudes toward these issues. Both before & after the campaign, white adults were less likely than blacks to believe public schools should provide primary health care services to teenagers but more likely to favor sexual experimentation by adolescents & to favor abortion. Informational campaigns targeted toward modifying attitudes on these issues may require more than 3 years to have an impact. 3 Tables, 9 References. Adapted from the source document. JF - Health Values AU - Horner, Ronnie D AU - Kolasa, Kathryn M AU - Irons, Thomas AD - HSR&D (152) Veterans Administration Medical Center, 508 Fulton St Durham NC 27858 Y1 - 1995/05// PY - 1995 DA - May 1995 SP - 5 EP - 11 VL - 19 IS - 3 SN - 0147-0353, 0147-0353 KW - adolescent health/sexuality issues, black vs white adults' attitudes, rural North Carolina KW - community-wide health promotion campaign KW - surveys KW - Sexual Behavior KW - Black White Differences KW - Social Attitudes KW - North Carolina KW - Health Behavior KW - Health Education KW - Adolescents KW - article KW - 0410: group interactions; social group identity & intergroup relations (groups based on race & ethnicity, age, & sexual orientation) KW - 1940: the family and socialization; sociology of sexual behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61411989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Values&rft.atitle=Racial+Differences+in+Rural+Adults%27+Views+on+Adolescent+Sexuality+--+Revisited&rft.au=Horner%2C+Ronnie+D%3BKolasa%2C+Kathryn+M%3BIrons%2C+Thomas&rft.aulast=Horner&rft.aufirst=Ronnie&rft.date=1995-05-01&rft.volume=19&rft.issue=3&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Health+Values&rft.issn=01470353&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - HEVAEC N1 - SubjectsTermNotLitGenreText - North Carolina; Adolescents; Health Behavior; Sexual Behavior; Health Education; Black White Differences; Social Attitudes ER - TY - JOUR T1 - Effect of Therapeutic Innovation on Perception of Disease and the Doctor-Patient Relationship: A History of General Paralysis of the Insane and Malaria Fever Therapy, 1910-1950 AN - 61409180; 9511834 AB - The impact of therapeutic innovation on the interpersonal style of physicians (MDs) is examined through historical analysis of the introduction of malaria fever therapy (MFT) for the treatment of general paralysis of the insane, conducted through review of Patton State Hospital (CA) records of 129 pre-MFT & MFT-era patients admitted 1910-1950. Contrary to the expectation that the introduction of MFT would result in MDs perceiving patients more as carriers of a disease & less as individuals suffering from illness, the MFT innovation resulted in MDs viewing their patients with greater empathy. The clinical optimism produced by the therapeutic innovation appeared to be the crucual factor in changing the MD's orientation & style. 23 References. D. Generoli JF - The American Journal of Psychiatry AU - Braslow, Joel T AD - Primary Ambulatory Care & Education Program Veterans Administration, 16111 Plummer St Sepulveda CA 91343 Y1 - 1995/05// PY - 1995 DA - May 1995 SP - 660 EP - 665 VL - 152 IS - 5 SN - 0002-953X, 0002-953X KW - physicians' interpersonal style KW - therapeutic innovations KW - historical case study KW - malaria fever therapy, 1910-1950 hospital patients, California KW - California KW - Peoples Republic of China KW - Mental Patients KW - Social History KW - Medicine KW - Physicians KW - Diseases KW - Innovations KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61409180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Effect+of+Therapeutic+Innovation+on+Perception+of+Disease+and+the+Doctor-Patient+Relationship%3A+A+History+of+General+Paralysis+of+the+Insane+and+Malaria+Fever+Therapy%2C+1910-1950&rft.au=Braslow%2C+Joel+T&rft.aulast=Braslow&rft.aufirst=Joel&rft.date=1995-05-01&rft.volume=152&rft.issue=5&rft.spage=660&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Peoples Republic of China; Physicians; Medicine; Innovations; Mental Patients; California; Diseases; Social History ER - TY - JOUR T1 - Withdrawal and Dependency Symptoms among Adolescent Alcohol and Drug Abusers AN - 61380952; 9514612 AB - Examines the withdrawal & dependency symptoms of 166 adolescents recruited from inpatient alcohol & drug treatment programs in the US, drawing on questionnaire & interview data. Adolescents were all multiple substance users with a life-time average of 4.27 drugs used in addition to alcohol. Amphetamines were the most frequently used drug (50% of sample) & the most prevalent withdrawal symptoms were those associated with central stimulant use. However, the number of different withdrawal symptoms (mean = 11.27) was greater than expected for uncomplicated stimulant withdrawal or withdrawal from any single substance. On average, participants reported more dependency symptoms than required by DSM-III-R criteria for the diagnosis of alcohol dependency, as well as dependency on their 2 most frequently used drugs. Heavy alcohol & cigarette use were found to exacerbate withdrawal symptoms of other drugs. 2 Tables, 39 References. Adapted from the source document. JF - Addiction AU - Stewart, David G AU - Brown, Sandra A AD - San Diego Psychology Service Veterans Administration Medical Center, 3350 La Jolla Village Dr CA 92161 Y1 - 1995/05// PY - 1995 DA - May 1995 SP - 627 EP - 635 VL - 90 IS - 5 SN - 0965-2140, 0965-2140 KW - withdrawal/dependency symptoms, adolescent substance abusers KW - questionnaire/interview data KW - inpatient treatment program participants, US KW - Detoxification KW - Symptoms KW - Drug Addiction KW - Treatment Programs KW - Alcoholism KW - United States of America KW - Adolescents KW - article KW - 1939: the family and socialization; adolescence & youth KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61380952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Withdrawal+and+Dependency+Symptoms+among+Adolescent+Alcohol+and+Drug+Abusers&rft.au=Stewart%2C+David+G%3BBrown%2C+Sandra+A&rft.aulast=Stewart&rft.aufirst=David&rft.date=1995-05-01&rft.volume=90&rft.issue=5&rft.spage=627&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Alcoholism; Drug Addiction; Adolescents; Detoxification; Symptoms; Treatment Programs; United States of America ER - TY - JOUR T1 - The propeptide is nonessential for the expression of human cathepsin D. AN - 77242775; 7730356 AB - When the 44-amino acid propeptide of human procathepsin D was deleted by mutagenesis in vitro, the mature protein was stably expressed and secreted from transfected mammalian cells. The secreted protein was correctly folded as judged by its binding to pepstatinylagarose. We were unable to detect lysosomal targeting of the propeptide-deleted protein, and targeting was not restored by the substitution of the propeptides from pepsin or renin. We conclude that its propeptide is not essential for the folding of nascent cathepsin D. Efficient lysosomal targeting in mammalian cells appears to require the precursor form of the molecule. JF - The Journal of biological chemistry AU - Fortenberry, S C AU - Chirgwin, J M AD - Research Service, Audie L. Murphy Veterans Administration Medical Center, San Antonio, Texas, USA. Y1 - 1995/04/28/ PY - 1995 DA - 1995 Apr 28 SP - 9778 EP - 9782 VL - 270 IS - 17 SN - 0021-9258, 0021-9258 KW - Enzyme Precursors KW - 0 KW - Peptides KW - Cathepsin D KW - EC 3.4.23.5 KW - Index Medicus KW - Animals KW - Humans KW - Protein Processing, Post-Translational KW - Peptides -- metabolism KW - CHO Cells KW - Lysosomes -- metabolism KW - Cell Line KW - Cricetinae KW - Cathepsin D -- metabolism KW - Cathepsin D -- genetics KW - Enzyme Precursors -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77242775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=The+propeptide+is+nonessential+for+the+expression+of+human+cathepsin+D.&rft.au=Fortenberry%2C+S+C%3BChirgwin%2C+J+M&rft.aulast=Fortenberry&rft.aufirst=S&rft.date=1995-04-28&rft.volume=270&rft.issue=17&rft.spage=9778&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-06-01 N1 - Date created - 1995-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Performance as a function of time: a study of three cochlear implant devices. AN - 85422069; pmid-7717630 AB - This study examines the relationship of time to cochlear implant patient performance and the effect of device design on patient performance over time. Data were collected for patients who were implanted with Nucleus 22, Smith & Nephew Richards Ineraid, or 3M/Vienna cochlear implants as part of the Veterans Administration study on cochlear implants. Patients were administered a comprehensive audiological test battery prior to implantation, at stimulation, and 3 months, 1 year, and 2 years poststimulation. Results show that patient performance improved over the course of the study, with performance levels with each multichannel implant being similar at the study end point. The Nucleus device produced maximum performance sooner than the Ineraid device did, and performance of the single-channel 3M was consistently below that of the multichannel devices. JF - The Annals of otology, rhinology & laryngology. Supplement AU - Weston, S C AU - Waltzman, S B AD - Department of Speech Pathology and Audiology, Veterans Administration Medical Center, Long Beach, California, USA. Y1 - 1995/04// PY - 1995 DA - April 1995 SP - 19 EP - 24 VL - 165 SN - 0096-8056, 0096-8056 KW - Index Medicus KW - National Library of Medicine KW - Equipment Design KW - Prospective Studies KW - Humans KW - Treatment Outcome KW - Deafness -- rehabilitation KW - Cochlear Implants KW - Deafness -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85422069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+otology%2C+rhinology+%26+laryngology.+Supplement&rft.atitle=Performance+as+a+function+of+time%3A+a+study+of+three+cochlear+implant+devices.&rft.au=Weston%2C+S+C%3BWaltzman%2C+S+B&rft.aulast=Weston&rft.aufirst=S&rft.date=1995-04-01&rft.volume=165&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+otology%2C+rhinology+%26+laryngology.+Supplement&rft.issn=00968056&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-02-28 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Change in the quality of life of adult cochlear implant patients. AN - 85420419; pmid-7717632 AB - Changes in the quality of life perceived by patients over a 24-month period were examined by means of three questionnaires: the Patient Quality of Life Form, the Index Relative Questionnaire Form, and the Performance Inventory for Profound Hearing Loss Answer Form. In addition, the relationships among the three questionnaires were examined as a function of age, length of deafness, and a battery of selected audiological tests. The results of the study indicate that a cochlear implant makes significant, positive changes in the quality of life of patients and in their ability to communicate. The patients and their relatives differ somewhat in their perceptions of these changes. The degree of improvement in quality of life perceived by a patient as the result of an implant is a function of the years of deafness. In general, the longer an individual has been deaf, the less improvement in quality of life that is perceived. JF - The Annals of otology, rhinology & laryngology. Supplement AU - Maillet, C J AU - Tyler, R S AU - Jordan, H N AD - Department of Speech Pathology and Audiology, Iowa City Veterans Administration Medical Center, Iowa, USA. Y1 - 1995/04// PY - 1995 DA - April 1995 SP - 31 EP - 48 VL - 165 SN - 0096-8056, 0096-8056 KW - Index Medicus KW - National Library of Medicine KW - Questionnaires KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Quality of Life KW - Cochlear Implants KW - Deafness -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85420419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+otology%2C+rhinology+%26+laryngology.+Supplement&rft.atitle=Change+in+the+quality+of+life+of+adult+cochlear+implant+patients.&rft.au=Maillet%2C+C+J%3BTyler%2C+R+S%3BJordan%2C+H+N&rft.aulast=Maillet&rft.aufirst=C&rft.date=1995-04-01&rft.volume=165&rft.issue=&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+otology%2C+rhinology+%26+laryngology.+Supplement&rft.issn=00968056&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2008-02-28 N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Combination chemotherapy extends the therapeutic window to 60 minutes after stroke. AN - 77427392; 7629868 AB - We sought to extend the therapeutic window for acute stroke therapy using the combination of a glutamate antagonist and a GABA agonist, which in prior studies was effective if given 5 min after stroke. We used a quantal bioassay to measure neuroprotective potency after injection of several thousand microspheres into the cerebral circulation of rats. The GABA-A agonist muscimol, but not MK-801, was effective if given 30, 45, or 60 min after embolization (potency ratio compared with saline of 3.0, 2.3, 1.8, respectively). If muscimol was combined with MK-801 at lower doses of each drug, the combination was neuroprotective (potency ratio of 4.2). Agonists of GABA-A, but not GABA-B, receptors blocked the toxic vacuolization seen in the cingulate and retrosplenial cortex after MK-801 treatment. Combination chemotherapy appears to extend the time window for acute stroke therapy in rats to 1 h and to result in fewer side effects. JF - Journal of neurotrauma AU - Lyden, P AU - Lonzo, L AU - Nunez, S AD - Department of Neurosciences, UCSD School of Medicine, Veterans Administration Medical Center, California, USA. Y1 - 1995/04// PY - 1995 DA - April 1995 SP - 223 EP - 230 VL - 12 IS - 2 SN - 0897-7151, 0897-7151 KW - Excitatory Amino Acid Antagonists KW - 0 KW - GABA Agonists KW - GABA-A Receptor Agonists KW - GABA-B Receptor Agonists KW - Neuroprotective Agents KW - Muscimol KW - 2763-96-4 KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - Index Medicus KW - Animals KW - Brain -- drug effects KW - Dizocilpine Maleate -- therapeutic use KW - Microspheres KW - Neuroprotective Agents -- pharmacology KW - Drug Therapy, Combination KW - Rats KW - Vacuoles -- ultrastructure KW - Rats, Sprague-Dawley KW - Brain -- pathology KW - Muscimol -- therapeutic use KW - Time Factors KW - Male KW - GABA Agonists -- therapeutic use KW - Cerebrovascular Disorders -- drug therapy KW - Cerebrovascular Disorders -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77427392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurotrauma&rft.atitle=Combination+chemotherapy+extends+the+therapeutic+window+to+60+minutes+after+stroke.&rft.au=Lyden%2C+P%3BLonzo%2C+L%3BNunez%2C+S&rft.aulast=Lyden&rft.aufirst=P&rft.date=1995-04-01&rft.volume=12&rft.issue=2&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurotrauma&rft.issn=08977151&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-09-01 N1 - Date created - 1995-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A double-blind, placebo-controlled study of nortriptyline and bromocriptine in male alcoholics subtyped by comorbid psychiatric disorders. AN - 77423658; 7625583 AB - This double-blind, placebo-controlled, 6-month follow-up treatment study investigated the efficacy of bromocriptine and nortriptyline in attenuating drinking behavior and psychiatric symptoms in 216 male alcoholic patients subtyped by comorbid psychiatric disorder(s). Three well-defined subtypes were examined: alcoholism only, alcoholism + affective/anxiety disorder, and alcoholism + antisocial personality disorder. It was hypothesized that both medications would relieve negative affective symptoms associated with alcohol use and would be particularly effective for the affective/anxiety subgroup. Contrary to our predictions, the only significant effects found were with the antisocial personality disorder patients who were receiving nortriptyline. One interpretation of the results was that nortriptyline may have reduced impulsive drinking in the antisocial personality disorder subgroup by actions on serotonergic neurotransmission. JF - Alcoholism, clinical and experimental research AU - Powell, B J AU - Campbell, J L AU - Landon, J F AU - Liskow, B I AU - Thomas, H M AU - Nickel, E J AU - Dale, T M AU - Penick, E C AU - Samuelson, S D AU - Lacoursiere, R B AD - Kansas City Veterans Administration Medical Center (151), Kansas City 64128, USA. Y1 - 1995/04// PY - 1995 DA - April 1995 SP - 462 EP - 468 VL - 19 IS - 2 SN - 0145-6008, 0145-6008 KW - Bromocriptine KW - 3A64E3G5ZO KW - Nortriptyline KW - BL03SY4LXB KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Double-Blind Method KW - Humans KW - Adult KW - Social Behavior KW - Personality Inventory KW - Middle Aged KW - Follow-Up Studies KW - Antisocial Personality Disorder -- rehabilitation KW - Antisocial Personality Disorder -- classification KW - Antisocial Personality Disorder -- psychology KW - Male KW - Comorbidity KW - Alcoholism -- rehabilitation KW - Bromocriptine -- adverse effects KW - Anxiety Disorders -- classification KW - Anxiety Disorders -- psychology KW - Depressive Disorder -- psychology KW - Bromocriptine -- therapeutic use KW - Nortriptyline -- adverse effects KW - Veterans -- psychology KW - Anxiety Disorders -- rehabilitation KW - Alcoholism -- psychology KW - Nortriptyline -- therapeutic use KW - Alcoholism -- classification KW - Depressive Disorder -- classification KW - Depressive Disorder -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77423658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=A+double-blind%2C+placebo-controlled+study+of+nortriptyline+and+bromocriptine+in+male+alcoholics+subtyped+by+comorbid+psychiatric+disorders.&rft.au=Powell%2C+B+J%3BCampbell%2C+J+L%3BLandon%2C+J+F%3BLiskow%2C+B+I%3BThomas%2C+H+M%3BNickel%2C+E+J%3BDale%2C+T+M%3BPenick%2C+E+C%3BSamuelson%2C+S+D%3BLacoursiere%2C+R+B&rft.aulast=Powell&rft.aufirst=B&rft.date=1995-04-01&rft.volume=19&rft.issue=2&rft.spage=462&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-08-29 N1 - Date created - 1995-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Misoprostol reverses the inhibition of gastric hyperemia and aggravation of gastric damage by tobacco cigarette smoke in the rat. AN - 77394829; 7610345 AB - Tobacco cigarette smoke attenuates injury-induced hyperemia, aggravates hypertonic saline-induced mucosal damage, inhibits ulcer margin hyperemia, and increases the size of the acetic acid-induced ulcer in the rat stomach. The inhibitory effect of tobacco cigarette smoke on gastric prostaglandin metabolism may be the basis for these observations. We have tested the hypothesis that exogenous prostaglandin (misoprostol) treatment will reverse these effects. Rats with these two types of gastric injury were treated with tobacco cigarette smoke or breathed room air and were given intragastric misoprostol or vehicle. Gastric mucosal blood flow was measured by hydrogen gas clearance, and lesion score or ulcer size was measured by image analysis. Tobacco cigarette smoke attenuated the hyperemia and significantly aggravated the mucosal lesions and increased ulcer size. Treatment with intragastric misoprostol preserved the hyperemia and significantly attenuated the exacerbation of mucosal damage or increase in ulcer size produced by tobacco cigarette smoke. These data are consistent with the hypothesis that the attenuation of injury-induced or ulcer margin hyperemia by tobacco cigarette smoke is mediated by the inhibition of endogenous prostaglandins. JF - Scandinavian journal of gastroenterology AU - Iwata, F AU - Leung, F W AD - Research Service, Sepulveda Veterans Administration Medical Center, CA 91343, USA. Y1 - 1995/04// PY - 1995 DA - April 1995 SP - 315 EP - 321 VL - 30 IS - 4 SN - 0036-5521, 0036-5521 KW - Acetates KW - 0 KW - Saline Solution, Hypertonic KW - Misoprostol KW - 0E43V0BB57 KW - Acetic Acid KW - Q40Q9N063P KW - Index Medicus KW - Rats KW - Animals KW - Analysis of Variance KW - Acetates -- adverse effects KW - Regional Blood Flow -- drug effects KW - Saline Solution, Hypertonic -- adverse effects KW - Male KW - Stomach Ulcer -- pathology KW - Stomach Ulcer -- chemically induced KW - Misoprostol -- pharmacology KW - Hyperemia -- pathology KW - Smoking -- adverse effects KW - Hyperemia -- prevention & control KW - Gastric Mucosa -- blood supply KW - Gastric Mucosa -- drug effects KW - Hyperemia -- physiopathology KW - Gastric Mucosa -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77394829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+journal+of+gastroenterology&rft.atitle=Misoprostol+reverses+the+inhibition+of+gastric+hyperemia+and+aggravation+of+gastric+damage+by+tobacco+cigarette+smoke+in+the+rat.&rft.au=Iwata%2C+F%3BLeung%2C+F+W&rft.aulast=Iwata&rft.aufirst=F&rft.date=1995-04-01&rft.volume=30&rft.issue=4&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Scandinavian+journal+of+gastroenterology&rft.issn=00365521&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-08-15 N1 - Date created - 1995-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adequacy of Social Work Practice: An Evaluative Framework AN - 61530018; 199800891 AB - Reviews five currently available frameworks for analyzing the adequacy of social work practice theories, & presents a new framework that provides practitioners with practical & comprehensive guidelines for selecting practice theories. This new framework allows for assignment of numerical values to theories, thereby providing a more empirical tool for evaluation & selection. It is recommended that research should establish validity & reliability of this framework & should include development of standardized scores for theories. 8 References. Adapted from the source document. JF - The Journal of Applied Social Sciences AU - Dixon, Danny AU - Holzhalb, Carol AU - Kelly, Tim AU - Leslie, Don AU - Sutphen, Richard AU - Kilpatrick, Allie AD - Social Work Service (122) Veterans Administration Medical Center, 1601 Brennen Ave Salisbury NC 28144 Y1 - 1995/04// PY - 1995 DA - April 1995 SP - 129 EP - 135 VL - 19 IS - 2 SN - 0146-4310, 0146-4310 KW - Theory Practice Relationship KW - Social Work KW - article KW - 6150: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61530018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Applied+Social+Sciences&rft.atitle=Adequacy+of+Social+Work+Practice%3A+An+Evaluative+Framework&rft.au=Dixon%2C+Danny%3BHolzhalb%2C+Carol%3BKelly%2C+Tim%3BLeslie%2C+Don%3BSutphen%2C+Richard%3BKilpatrick%2C+Allie&rft.aulast=Dixon&rft.aufirst=Danny&rft.date=1995-04-01&rft.volume=19&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Applied+Social+Sciences&rft.issn=01464310&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Social Work; Theory Practice Relationship ER - TY - RPRT T1 - VETERANS AFFAIRS MEDICAL AND REGIONAL OFFICE CENTER, TRIPLER ARMY MEDICAL CENTER, OAHU, HONOLULU COUNTY, HAWAII. AN - 36397380; 5066 AB - PURPOSE: The construction of a Department of Veterans Affairs (VA) medical and regional office center at Tripler Army Medical Center in Oahu, Hawaii, is proposed. The center would provide overall medical services to the growing veterans population in Hawaii. The VA does not have a hospital, nursing home, or state veterans home in Hawaii; as a result, services have been fragmented and dispersed among a variety of facilities scattered throughout the community. Two alternatives, including a No Action Alternative, are considered in this final EIS. Under the proposed action, the center would be designed to provide medical care for an estimated 91,800 outpatient visits annually by the year 2005. The major components of the new center would include the 105-bed Medical Center, a 60-bed nursing home, and the renovation of a present wing (E-wing) of the hospital to house the VA's regional office. The medical center would be housed in a new 326,800-square-foot, five-story structure that would function as the main medical facility, with three levels of ancillary/outpatient services and two inpatient levels. The medical center would be staffed by 704 full-time employees. The center for aging would be housed in a 42,700-square-foot, single-story building with 63 on-site parking spaces; it would employ 50 persons. Four of the five stories of the hospital's E-wing would be renovated to accommodate the VA's administrative and engineering offices, the Veterans Benefit Administration, vocational rehabilitation and counseling services, and various veterans service organizations. These activities are currently located in the Federal Building in downtown Honolulu. An estimated 230 persons would be employed in this portion of the facility. The project would also provide 979 parking spaces in several modes and locations to accommodate visitors, patients, and staff. The estimated construction costs of the project are $110.9 million. POSITIVE IMPACTS: The facility would consolidate, centralize, and expand the VA's health and benefit services in Hawaii. Sharing staff and services with Tripler Hospital would help to eliminate duplicative staff and services and reduce operating costs for both the VA and the Army. NEGATIVE IMPACTS: The facility would significantly increase traffic congestion at three key intersections. Perched ground water could be encountered at the project site during construction. Although dewatering activities would be minimal, implementation of control measures could be necessary in order to protect against the discharges of dewatering effluent. LEGAL MANDATES: Federal Water Pollution Control Act of 1972 (33 U.S.C. 1251 et seq.). PRIOR REFERENCES: For the abstract of the draft EIS, see 94-0346D, Volume 18, Number 4. JF - EPA number: 950072, 460 pages and maps, March 3, 1995 PY - 1995 KW - Urban and Social Programs KW - Buildings KW - Employment KW - Hospitals KW - Land Use KW - Parking KW - Traffic Analyses KW - Water Quality KW - Hawaii KW - Federal Water Pollution Control Act of 1972, NPDES Permits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36397380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1995-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=VETERANS+AFFAIRS+MEDICAL+AND+REGIONAL+OFFICE+CENTER%2C+TRIPLER+ARMY+MEDICAL+CENTER%2C+OAHU%2C+HONOLULU+COUNTY%2C+HAWAII.&rft.title=VETERANS+AFFAIRS+MEDICAL+AND+REGIONAL+OFFICE+CENTER%2C+TRIPLER+ARMY+MEDICAL+CENTER%2C+OAHU%2C+HONOLULU+COUNTY%2C+HAWAII.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Veterans Affairs, Veterans Health Administration, Washington, District of Columbia; VA N1 - Date revised - 2006-05-01 N1 - SuppNotes - Final. Preparation date: March 3, 1995 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Prenatal alcohol exposure and pineal response to isoproterenol, vasoactive intestinal polypeptide, and desmethylimipramine. AN - 77429634; 7629691 AB - Pineals from neonatal rats born to alcohol-fed mothers had lower unstimulated serotonin-N-acetyltransferase activity (NAT) and responded less to isoproterenol, vasoactive intestinal polypeptide, or desmethylimipramine challenge than did pineals from pups born to normal or pair-fed mothers. Group differences disappeared after the first week of life. Reduced NAT activity is coincident with elevated glucocorticoids in these pups. In contrast to these effects of chronic in utero ethanol exposure, acute ethanol addition to normal adult pineals in organ culture enhanced ISO but not VIP stimulation of NAT activity. The results suggest that the neonatal pineal is more affected by ethanol-induced activation of the adrenocortical axis during gestation than by the direct effect of ethanol on membrane fluidity. JF - Journal of pineal research AU - Yuwiler, A AU - Taylor, A N AD - Neurobiochemistry Laboratory T-85, West Los Angeles Veterans Administration Medical Center Brentwood Division, CA 90073, USA. Y1 - 1995/03// PY - 1995 DA - March 1995 SP - 57 EP - 61 VL - 18 IS - 2 SN - 0742-3098, 0742-3098 KW - Vasoactive Intestinal Peptide KW - 37221-79-7 KW - Ethanol KW - 3K9958V90M KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - Isoproterenol KW - L628TT009W KW - Desipramine KW - TG537D343B KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Random Allocation KW - Animals, Newborn -- growth & development KW - Animals, Newborn -- metabolism KW - Organ Culture Techniques KW - Arylamine N-Acetyltransferase -- metabolism KW - Male KW - Female KW - Pregnancy KW - Vasoactive Intestinal Peptide -- pharmacology KW - Desipramine -- pharmacology KW - Pineal Gland -- enzymology KW - Ethanol -- toxicity KW - Pineal Gland -- drug effects KW - Isoproterenol -- pharmacology KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77429634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pineal+research&rft.atitle=Prenatal+alcohol+exposure+and+pineal+response+to+isoproterenol%2C+vasoactive+intestinal+polypeptide%2C+and+desmethylimipramine.&rft.au=Yuwiler%2C+A%3BTaylor%2C+A+N&rft.aulast=Yuwiler&rft.aufirst=A&rft.date=1995-03-01&rft.volume=18&rft.issue=2&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Journal+of+pineal+research&rft.issn=07423098&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-09-07 N1 - Date created - 1995-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Group B streptococcal vertebral osteomyelitis with bacteremia. AN - 77169148; 7886535 AB - Group B streptococcal vertebral osteomyelitis is rare in adults. Osteomyelitis due to this organism is in general related to contiguous infections, recent surgery, or peripheral vascular disease. All reported cases of group B streptococcal vertebral osteomyelitis, however, have had no association with these predisposing factors and have usually been presumed to be of hematogenous origin, though bacteremia has never been demonstrated. Here we describe a 45-year-old intravenous drug abuser who had vertebral osteomyelitis and bacteremia. We conclude that the vertebral osteomyelitis in this patient was hematogenous, as shown by bacteremia, and most likely resulted from intravenous needle use. JF - Southern medical journal AU - Ganapathy, M E AU - Rissing, J P AD - Section of Infectious Diseases, Veterans Administration Medical Center, Augusta, Ga. 30904-6285. Y1 - 1995/03// PY - 1995 DA - March 1995 SP - 350 EP - 351 VL - 88 IS - 3 SN - 0038-4348, 0038-4348 KW - Abridged Index Medicus KW - Index Medicus KW - Bacteremia -- microbiology KW - Sacrum -- microbiology KW - Humans KW - Middle Aged KW - Radiography KW - Substance Abuse, Intravenous -- complications KW - Male KW - Lumbar Vertebrae -- microbiology KW - Spinal Diseases -- diagnostic imaging KW - Streptococcal Infections -- microbiology KW - Streptococcus agalactiae KW - Osteomyelitis -- diagnostic imaging KW - Osteomyelitis -- microbiology KW - Spinal Diseases -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77169148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Group+B+streptococcal+vertebral+osteomyelitis+with+bacteremia.&rft.au=Ganapathy%2C+M+E%3BRissing%2C+J+P&rft.aulast=Ganapathy&rft.aufirst=M&rft.date=1995-03-01&rft.volume=88&rft.issue=3&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-04-12 N1 - Date created - 1995-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An Organizational Analysis of the World Health Organization: Narrowing the Gap between Promise and Performance AN - 61385159; 9509371 AB - After forty-five years of easing world suffering, the World Health Organization (WHO) has grown into a complex bureaucracy with organizational inefficiencies, conflicting incentives, & a limiting medical paradigm. The impending crisus due to insufficient funding of WHO is discussed, exploring the options of increasing efficiencies or increasing funding. Analysis of the structure, culture, mission, & rules of WHO within a multidisciplinary framework reveals components of rational & natural system types. A new organizational structure, based on an open systems model, is proposed that would give more authority to WHO representatives & staff at the country level, define budget constraints & policy boundaries, close regional offices, & establish open public elections of the Director General. For the complex social & economic issues facing WHO today, increased technical diversity & professional competence are needed. Adapted from the source document. JF - Social Science and Medicine AU - Peabody, John W AD - General Internal Medicine Division Veterans Administration, West Los Angeles CA Y1 - 1995/03// PY - 1995 DA - March 1995 SP - 731 EP - 742 VL - 40 IS - 6 SN - 0277-9536, 0277-9536 KW - organizational structure, World Health Organization, funding crisis context KW - Financial Support KW - Health Care KW - Organizational Structure KW - United Nations KW - Organizational Effectiveness KW - article KW - 0624: complex organization; bureaucratic structure/organizational sociology KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61385159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+and+Medicine&rft.atitle=An+Organizational+Analysis+of+the+World+Health+Organization%3A+Narrowing+the+Gap+between+Promise+and+Performance&rft.au=Peabody%2C+John+W&rft.aulast=Peabody&rft.aufirst=John&rft.date=1995-03-01&rft.volume=40&rft.issue=6&rft.spage=731&rft.isbn=&rft.btitle=&rft.title=Social+Science+and+Medicine&rft.issn=02779536&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Health Care; United Nations; Financial Support; Organizational Structure; Organizational Effectiveness ER - TY - JOUR T1 - Okadaic acid stimulates glucose transport in rat adipocytes by increasing the externalization rate constant of GLUT4 recycling. AN - 77157917; 7876140 AB - GLUT4, the major insulin-responsive glucose transporter isoform in rat adipocytes, rapidly recycles between the cell surface and an intracellular pool with two first order rate constants, one for internalization (kin) and the other for externalization (kex). Insulin decreases kin by 2.8-fold and increases kex by 3.3-fold, thus increasing the steady-state cell surface GLUT4 level by approximately 8-fold (Jhun, B. H., Rampal, A. L., Liu, H., Lachaal, M., and Jung, C. (1992) J. Biol. Chem. 267, 17710-17715). To gain an insight into the biochemical mechanisms that modulate these rate constants, we studied the effects upon them of okadaic acid (OKA), a phosphatase inhibitor that exerts a insulin-like effect on glucose transport in adipocytes. OKA stimulated 3-O-methylglucose transport maximally 3.1-fold and increased the cell surface GLUT4 level 3.4-fold. When adipocytes were pulse-labeled with an impermeant, covalently reactive glucose analog, [3H]1,3-bis-(3-deoxy-D-glucopyranose-3-yloxy)-2-propyl 4-benzoylbenzoate, and the time course of labeled GLUT4 recycling was followed, the kex was found to increase 2.8-fold upon maximal stimulation by OKA, whereas the kin remained unchanged within experimental error. These findings demonstrate that OKA mimics the insulin effect on only GLUT4 externalization and suggest that insulin stimulates GLUT4 externalization by increasing the phosphorylation state of a serine/threonine phosphoprotein, probably by inhibiting protein phosphatase 1 or 2A. JF - The Journal of biological chemistry AU - Rampal, A L AU - Jhun, B H AU - Kim, S AU - Liu, H AU - Manka, M AU - Lachaal, M AU - Spangler, R A AU - Jung, C Y AD - Biophysical Laboratory, Veterans Administration Medical Center, Buffalo, New York. Y1 - 1995/02/24/ PY - 1995 DA - 1995 Feb 24 SP - 3938 EP - 3943 VL - 270 IS - 8 SN - 0021-9258, 0021-9258 KW - Ethers, Cyclic KW - 0 KW - Glucose Transporter Type 4 KW - Insulin KW - Monosaccharide Transport Proteins KW - Muscle Proteins KW - Slc2a4 protein, rat KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Animals KW - Cell Membrane -- drug effects KW - Biological Transport KW - Insulin -- pharmacology KW - Subcellular Fractions -- drug effects KW - Rats KW - Blotting, Western KW - Phosphorylation KW - Cells, Cultured KW - Kinetics KW - Subcellular Fractions -- metabolism KW - Cell Membrane -- metabolism KW - Monosaccharide Transport Proteins -- metabolism KW - Glucose -- metabolism KW - Adipocytes -- metabolism KW - Ethers, Cyclic -- pharmacology KW - Adipocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77157917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Okadaic+acid+stimulates+glucose+transport+in+rat+adipocytes+by+increasing+the+externalization+rate+constant+of+GLUT4+recycling.&rft.au=Rampal%2C+A+L%3BJhun%2C+B+H%3BKim%2C+S%3BLiu%2C+H%3BManka%2C+M%3BLachaal%2C+M%3BSpangler%2C+R+A%3BJung%2C+C+Y&rft.aulast=Rampal&rft.aufirst=A&rft.date=1995-02-24&rft.volume=270&rft.issue=8&rft.spage=3938&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-03-31 N1 - Date created - 1995-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Serotonin uptake inhibitors modulate intracellular Ca2+ mobilization in platelets. AN - 77309874; 7774682 AB - The serotonin uptake inhibitors sertraline, paroxetine and fluoxetine were compared with imipramine and the calmodulin antagonists N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7) and calmidazolium, for their effects on intracellular Ca2+ mobilization in human platelets. All serotonin uptake inhibitors and calmodulin antagonists augmented thrombin-mediated increases in intracellular Ca2+. Sertraline, calmidazolium and W-7 also caused large dose-dependent increases in baseline levels of intracellular Ca2+. There was a rough correlation between the ability to elevate intracellular Ca2+ and potencies for inhibition of calmodulin. Neomycin, an inhibitor of inositol trisphosphate (IP3) generation, significantly inhibited the effects of sertaline. This is consistent with a role of IP3 and calmodulin in the effects of these drugs. JF - European journal of pharmacology AU - Helmeste, D M AU - Tang, S W AU - Reist, C AU - Vu, R AD - Department of Psychiatry, Veterans Administration Medical Center, Long Beach, CA 90822, USA. Y1 - 1995/02/15/ PY - 1995 DA - 1995 Feb 15 SP - 373 EP - 377 VL - 288 IS - 3 SN - 0014-2999, 0014-2999 KW - Calmodulin KW - 0 KW - Serotonin Uptake Inhibitors KW - Fluoxetine KW - 01K63SUP8D KW - Paroxetine KW - 41VRH5220H KW - 1-Naphthylamine KW - 9753I242R5 KW - Imipramine KW - OGG85SX4E4 KW - Sertraline KW - QUC7NX6WMB KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Fluoxetine -- pharmacology KW - 1-Naphthylamine -- analogs & derivatives KW - Cells, Cultured KW - Humans KW - Imipramine -- pharmacology KW - 1-Naphthylamine -- pharmacology KW - Paroxetine -- pharmacology KW - Calmodulin -- pharmacology KW - Calcium -- metabolism KW - Blood Platelets -- drug effects KW - Serotonin Uptake Inhibitors -- pharmacology KW - Blood Platelets -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77309874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Serotonin+uptake+inhibitors+modulate+intracellular+Ca2%2B+mobilization+in+platelets.&rft.au=Helmeste%2C+D+M%3BTang%2C+S+W%3BReist%2C+C%3BVu%2C+R&rft.aulast=Helmeste&rft.aufirst=D&rft.date=1995-02-15&rft.volume=288&rft.issue=3&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-07-11 N1 - Date created - 1995-07-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Eur J Pharmacol 1995 Jul 18;290(2):173-4 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Small bowel obstruction in pregnancy. AN - 85222400; pmid-7847305 AB - OBJECTIVES: Small bowel obstruction (SBO) is an unusual complication of pregnancy. Our objective was to review our experience at two urban hospitals. METHODS: To this end, we conducted a retrospective chart review of all pregnant patients with a discharge diagnosis of intestinal obstruction at Grace Hospital, Detroit, MI (January 1, 1972 to January 1, 1992) and Hutzel Hospital, Detroit, MI (January 1, 1977 to January 1, 1992). RESULTS: During the study period, nine cases of SBO were identified and 150,386 deliveries occurred (one case per 16,709 deliveries). Patients' ages ranged from 16 to 37 yr. There were six primiparas. Cases of SBO by trimester: four in second, four in third, and one in puerperium. Previous abdominal surgery was documented in eight patients. Duration of symptoms before admission ranged from 3 h to 3 days. Primary symptoms were abdominal pain (89%), vomiting (89%), and obstipation (80%). At admission, only one patient was febrile, and four had hypoactive bowel sounds. Abdominal x-rays were compatible with SBO in seven patients. Ultrasound identified SBO in one of four cases. Patients were hospitalized 6 h to 23 days before surgery. The admission diagnosis was incorrect in four cases. One patient was treated conservatively and, at 36 wk, vaginally delivered a healthy infant. The eight surgical patients had lysis of adhesions, with one requiring resection of gangrenous small bowel. There were three fetal deaths (at 22, 24, and 30 wk of gestation). No maternal deaths occurred. CONCLUSION: SBO is a rare, but often catastrophic, complication during pregnancy and the puerperium. Clinical suspicion is critical and should be increased in a patient with an abdominal scar. If suspected, prompt abdominal x-rays, ultrasound, and surgical consultation are warranted. JF - The American Journal of Gastroenterology AU - Meyerson, S AU - Holtz, T AU - Ehrinpreis, M AU - Dhar, R AD - Veterans Administration Hospital, Wilmington, Delaware. PY - 1995 SP - 299 EP - 302 VL - 90 IS - 2 SN - 0002-9270, 0002-9270 KW - Medical Records KW - Human KW - Adult KW - Retrospective Studies KW - Incidence KW - Michigan KW - Hospitals, Urban KW - Adolescent KW - Female KW - Pregnancy Outcome KW - Pregnancy KW - Intestinal Obstruction KW - Pregnancy Complications KW - Intestine, Small UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85222400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Small+bowel+obstruction+in+pregnancy.&rft.au=Meyerson%2C+S%3BHoltz%2C+T%3BEhrinpreis%2C+M%3BDhar%2C+R&rft.aulast=Meyerson&rft.aufirst=S&rft.date=1995-02-01&rft.volume=90&rft.issue=2&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Problematic wandering behavior in the cognitively impaired elderly. A single-subject case study. AN - 77297687; 7769578 AB - Three psychosocial factors that may influence wandering behavior have been previously identified: lifelong patterns of coping with stress, previous work roles, and a need to search for persons or places associated with security. Strategies for managing wandering behavior include environmental modifications, planned activities, physical exercise, and attention to psychosocial history. However, limited attention has been given to testing psychosocial approaches that could be used by nursing home staff when interacting with residents who wander. The findings of this study suggest that providing sufficient staff time for interacting with residents, programs that address residents' needs for activity and rest, and appropriate environmental modifications should occur in conjunction with the decreased use of antipsychotic medications and physical restraints. JF - Journal of psychosocial nursing and mental health services AU - Goldsmith, S M AU - Hoeffer, B AU - Rader, J AD - Veterans Administration Medical Center, Portland, OR 97207, USA. Y1 - 1995/02// PY - 1995 DA - February 1995 SP - 6 EP - 12 VL - 33 IS - 2 SN - 0279-3695, 0279-3695 KW - Psychotropic Drugs KW - 0 KW - Index Medicus KW - Nursing KW - Homes for the Aged KW - Restraint, Physical KW - Intermediate Care Facilities KW - Nursing Assessment KW - Combined Modality Therapy KW - Nurse Clinicians KW - Humans KW - Activities of Daily Living -- psychology KW - Mental Status Schedule KW - Aged KW - Psychotropic Drugs -- adverse effects KW - Psychotropic Drugs -- administration & dosage KW - Nurse-Patient Relations KW - Nursing Homes KW - Male KW - Orientation KW - Motor Activity KW - Alzheimer Disease -- psychology KW - Behavior Therapy -- methods KW - Alzheimer Disease -- nursing KW - Social Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77297687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychosocial+nursing+and+mental+health+services&rft.atitle=Problematic+wandering+behavior+in+the+cognitively+impaired+elderly.+A+single-subject+case+study.&rft.au=Goldsmith%2C+S+M%3BHoeffer%2C+B%3BRader%2C+J&rft.aulast=Goldsmith&rft.aufirst=S&rft.date=1995-02-01&rft.volume=33&rft.issue=2&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychosocial+nursing+and+mental+health+services&rft.issn=02793695&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-07-06 N1 - Date created - 1995-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of an in vivo model to determine the effects of interleukin-1 on cells at different stages in the osteoclast lineage. AN - 77279538; 7754810 AB - In vitro model systems have been used extensively to study factors that affect osteoclast formation and to identify osteoclast precursors. However, in vitro systems do not examine the entire process of osteoclast differentiation simultaneously and lack accessory cells normally present in vivo. Additionally, the role that metabolism of the factor may play on its osteotropic activity in vivo is not addressed by these culture systems. Therefore, we have developed an in vivo model that permits us to examine simultaneously the effects of osteotropic factors on three distinct stages of osteoclast differentiation: (1) multipotent osteoclast precursors, the granulocyte-macrophage colony-forming unit (CFU-GM); (2) more differentiated marrow mononuclear osteoclast precursors; and (3) mature osteoclasts already present on bone surfaces. In the current study, we used interleukin-1 (IL-1) as a prototypic osteotropic factor to test the utility of this system to delineate the cellular mechanisms responsible for enhanced osteoclast activity stimulated by this cytokine. IL-1 induced hypercalcemia and enhanced the growth and differentiation of CFU-GM, increased the number of more committed mononuclear osteoclast precursors, and stimulated mature osteoclasts to resorb bone. These data demonstrate that this simple in vivo model permits the easy delineation of the stages of osteoclast development, in which osteotropic factors act to enhance bone turnover, and may be useful in understanding the mechanism of action of antiresorptive agents. JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research AU - Uy, H L AU - Dallas, M AU - Calland, J W AU - Boyce, B F AU - Mundy, G R AU - Roodman, G D AD - Audie Murphy Veterans Administration Hospital, San Antonio, Texas, USA. Y1 - 1995/02// PY - 1995 DA - February 1995 SP - 295 EP - 301 VL - 10 IS - 2 SN - 0884-0431, 0884-0431 KW - Interleukin-1 KW - 0 KW - Recombinant Proteins KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Specific Pathogen-Free Organisms KW - Animals KW - Analysis of Variance KW - Recombinant Proteins -- pharmacology KW - Spleen -- cytology KW - Calcium -- blood KW - Femur -- cytology KW - Hypercalcemia -- chemically induced KW - Mice KW - Mice, Inbred BALB C KW - Bone Marrow Cells KW - Femur -- metabolism KW - Cells, Cultured KW - Cell Differentiation -- drug effects KW - Colony-Forming Units Assay KW - Recombinant Proteins -- administration & dosage KW - Male KW - Stem Cells -- drug effects KW - Interleukin-1 -- pharmacology KW - Stem Cells -- cytology KW - Osteoclasts -- cytology KW - Interleukin-1 -- administration & dosage KW - Osteoclasts -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77279538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.atitle=Use+of+an+in+vivo+model+to+determine+the+effects+of+interleukin-1+on+cells+at+different+stages+in+the+osteoclast+lineage.&rft.au=Uy%2C+H+L%3BDallas%2C+M%3BCalland%2C+J+W%3BBoyce%2C+B+F%3BMundy%2C+G+R%3BRoodman%2C+G+D&rft.aulast=Uy&rft.aufirst=H&rft.date=1995-02-01&rft.volume=10&rft.issue=2&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.issn=08840431&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-06-19 N1 - Date created - 1995-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mast cell degranulation and blood-nerve barrier permeability in rat sciatic nerve after 7 days of hyperglycemia. AN - 77146655; 7864200 AB - The association between hyperglycemia and altered blood-nerve barrier permeability was examined after 7 days of experimental diabetes. In nerves of rats fed a diet of 40% galactose, permeability to [14C]mannitol [13.43 +/- 2.47 x 10(-5) (SD) ml.s-1.g dry wt-1] and water content [3.43 +/- 0.24 (SD) mg/mg dry wt] were significantly increased compared with control (9.24 +/- 2.09 x 10(-5) ml.s-1.g dry wt-1 and 2.15 +/- 0.28 mg/mg dry wt) and streptozotocin-diabetic animals (8.43 +/- 2.94 x 10(-5) ml.s.-1.g dry wt-1 and 2.35 +/- 0.56 mg/mg dry wt). Electron microscopy revealed significant increases in the number of degranulating perivascular mast cells and in an index of vasoconstriction in galactose-treated rats (3.8 +/- 1.6 and 0.160 +/- 0.062, respectively) compared with control (0.5 +/- 0.8 and 0.072 +/- 0.017, respectively) and diabetic animals (1.4 +/- 1.7 and 0.083 +/- 0.033, respectively). The data are consistent with a role for mast cells in permeability changes occurring after only 7 days of galactose intoxication. JF - The American journal of physiology AU - Kalichman, M W AU - Powell, H C AU - Calcutt, N A AU - Mizisin, A P AD - Veterans Administration Medical Center, San Diego, California. Y1 - 1995/02// PY - 1995 DA - February 1995 SP - H740 EP - H748 VL - 268 IS - 2 Pt 2 SN - 0002-9513, 0002-9513 KW - Mannitol KW - 3OWL53L36A KW - Streptozocin KW - 5W494URQ81 KW - Galactose KW - X2RN3Q8DNE KW - Index Medicus KW - Rats KW - Permeability KW - Animals KW - Rats, Sprague-Dawley KW - Nervous System -- metabolism KW - Microscopy, Electron KW - Galactose -- pharmacology KW - Time Factors KW - Female KW - Mannitol -- pharmacokinetics KW - Cell Degranulation KW - Hyperglycemia -- metabolism KW - Hyperglycemia -- chemically induced KW - Sciatic Nerve -- metabolism KW - Mast Cells -- physiology KW - Blood -- metabolism KW - Sciatic Nerve -- blood supply KW - Sciatic Nerve -- pathology KW - Hyperglycemia -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77146655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+physiology&rft.atitle=Mast+cell+degranulation+and+blood-nerve+barrier+permeability+in+rat+sciatic+nerve+after+7+days+of+hyperglycemia.&rft.au=Kalichman%2C+M+W%3BPowell%2C+H+C%3BCalcutt%2C+N+A%3BMizisin%2C+A+P&rft.aulast=Kalichman&rft.aufirst=M&rft.date=1995-02-01&rft.volume=268&rft.issue=2+Pt+2&rft.spage=H740&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+physiology&rft.issn=00029513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-03-20 N1 - Date created - 1995-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Expression of the extracellular domain of the thyrotropin receptor in the baculovirus system using a promoter active earlier than the polyhedrin promoter. Implications for the expression of functional highly glycosylated proteins. AN - 77135199; 7829482 AB - Conventional baculovirus vectors that utilize the very late polyhedrin promoter have not proved successful for expressing a thyrotropin (TSH) receptor capable of ligand and Graves' disease autoantibody binding comparable to the receptor produced in mammalian cells. Because of the clinical importance of high level expression of this protein, we reassessed the baculovirus system using a new transfer vector (pAcMP3) containing the late basic protein promoter, which functions earlier than the classical polyhedrin promoter. Maximal synthesis of the [35S]methionine-labeled TSH receptor extracellular domain, affinity-purified using a 6-histidine tag, occurred earlier (1 day after insect cell infection) than with a vector (pVL1393) containing the polyhedrin promoter. The pAcMP3-derived TSH receptor extracellular domain was larger (approximately 68 kDa) than the pVL1393-derived protein (approximately 63 kDa). Only the 68-kDa product was secreted, albeit in trace amounts detectable only by precursor labeling. Enzymatic deglycosylation reduced both 68- and 63-kDa cellular proteins to approximately 54 kDa, indicating that the pAcMP3 vector generated a protein with greater carbohydrate content. However, despite its greater degree of glycosylation, most of the 68-kDa protein remained within the cell, almost entirely in the particulate fraction. Remarkably, the trace amounts of 68-kDa receptor protein affinity-purified from the soluble cytosolic fraction of infected insect cells completely neutralized TSH receptor autoantibodies in patients' sera and partly inhibited TSH binding. In conclusion, a baculovirus vector with a promoter active earlier than the conventional polyhedrin promoter generates a more glycosylated and functional TSH receptor extracellular domain protein, albeit at low levels. These data carry important implications for the expression by baculovirus vectors of functional, highly glycosylated proteins. JF - The Journal of biological chemistry AU - Chazenbalk, G D AU - Rapoport, B AD - Thyroid Molecular Biology Unit, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1995/01/27/ PY - 1995 DA - 1995 Jan 27 SP - 1543 EP - 1549 VL - 270 IS - 4 SN - 0021-9258, 0021-9258 KW - DNA Primers KW - 0 KW - Receptors, Thyrotropin KW - Recombinant Fusion Proteins KW - Viral Proteins KW - Viral Structural Proteins KW - polyhedrin protein, Nucleopolyhedrovirus KW - Methionine KW - AE28F7PNPL KW - Index Medicus KW - Viral Proteins -- genetics KW - Recombinant Fusion Proteins -- biosynthesis KW - Animals KW - Spodoptera KW - Humans KW - Recombinant Fusion Proteins -- isolation & purification KW - Methionine -- metabolism KW - Glycosylation KW - Baculoviridae KW - Polymerase Chain Reaction KW - Base Sequence KW - Genetic Vectors KW - Kinetics KW - Restriction Mapping KW - Molecular Sequence Data KW - CHO Cells KW - Time Factors KW - Mutagenesis, Insertional KW - Sequence Deletion KW - Cricetinae KW - Promoter Regions, Genetic KW - Receptors, Thyrotropin -- biosynthesis KW - Transfection KW - Receptors, Thyrotropin -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77135199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Expression+of+the+extracellular+domain+of+the+thyrotropin+receptor+in+the+baculovirus+system+using+a+promoter+active+earlier+than+the+polyhedrin+promoter.+Implications+for+the+expression+of+functional+highly+glycosylated+proteins.&rft.au=Chazenbalk%2C+G+D%3BRapoport%2C+B&rft.aulast=Chazenbalk&rft.aufirst=G&rft.date=1995-01-27&rft.volume=270&rft.issue=4&rft.spage=1543&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-02-22 N1 - Date created - 1995-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone and parathyroid hormone-related protein contains positive and negative signals for endocytosis. AN - 77120398; 7814366 AB - The present studies were done to evaluate the role of the cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein (PTHrP) in the endocytosis of agonist-occupied receptors. PTH/PTHrP receptor mutants progressively truncated from the C terminus were expressed in COS-7 cells, and their ability to internalize 125I-PTHrP(1-34)amide was determined. Most of the C-terminal tail (91 of 127 residues) could be deleted without affecting internalization. However, further truncation removing residues 475-494 resulted in a 50-60% decrease in ligand internalization. A mutant with an internal deletion of these 20 amino acids showed a similar reduction in internalization, confirming the presence of a positive endocytic signal. No additional positive signals were found in the membrane-proximal region of the tail. However, alanine mutagenesis of the membrane-proximal residues 459-461 (EVQ-->AAA) resulted in a mutant PTH/PTHrP receptor displaying a 40% increase in ligand endocytosis, indicating that EVQ functions as a negative signal. Treatment of COS-7 cells with hypertonic sucrose (to disrupt clathrin lattices) markedly suppressed (by > 80%) PTH/PTHrP receptor internalization. These results demonstrate the presence of both positive and negative endocytic signals in the membrane-proximal cytoplasmic tail of the PTH/PTHrP receptor and suggest that these signals regulate the ability of the receptor to accumulate in clathrin-coated pits. JF - The Journal of biological chemistry AU - Huang, Z AU - Chen, Y AU - Nissenson, R A AD - Endocrine Research Unit, Veterans Administration Medical Center, San Francisco, California. Y1 - 1995/01/06/ PY - 1995 DA - 1995 Jan 06 SP - 151 EP - 156 VL - 270 IS - 1 SN - 0021-9258, 0021-9258 KW - Receptor, Parathyroid Hormone, Type 1 KW - 0 KW - Receptors, Parathyroid Hormone KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Index Medicus KW - Animals KW - Cattle KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Protein Binding KW - Mutation KW - Signal Transduction KW - Cell Line KW - Endocytosis KW - Cytoplasm -- metabolism KW - GTP-Binding Proteins -- metabolism KW - Receptors, Parathyroid Hormone -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77120398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=The+cytoplasmic+tail+of+the+G-protein-coupled+receptor+for+parathyroid+hormone+and+parathyroid+hormone-related+protein+contains+positive+and+negative+signals+for+endocytosis.&rft.au=Huang%2C+Z%3BChen%2C+Y%3BNissenson%2C+R+A&rft.aulast=Huang&rft.aufirst=Z&rft.date=1995-01-06&rft.volume=270&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-02-03 N1 - Date created - 1995-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Semantic Facilitation in Aphasia: Effects of Time and Expectancy AN - 85618637; 9509586 AB - Two auditory lexical decision semantic priming experiments examined the extent to which the automatic-controlled processing dichotomy can characterize lexical access deficits in Broca's & Wernicke's aphasics. In experiment 1 (N = 14 aphasics aged 43-78 & 20 normal controls), prime-target predictability was varied whereas the interval between prime & target (ISI) was held constant. In experiment 2 (N = 15 aphasics aged 43-78 & 20 normal controls), ISI was varied whereas prime-target predictability was held constant. Results of experiment 1 showed that Broca's aphasics were influenced by prime-target predictability; Wernicke's aphasics were not. In contrast, in experiment 2, manipulations of ISI at 150 & 2,000 msec did not affect patterns of semantic facilitation for either Broca's or Wernicke's aphasics, suggesting that Broca's aphasics use heuristic strategies more than old or young normal Ss. In addition, they seem to have an automatic processing deficit affecting the level of activation of lexical entries, with a spared time course of activation. Wernicke's aphasics show a pattern of results consistent with the view that their automatic processing is unimpaired, but they fail to use heuristic strategies in these tasks. 3 Tables, 5 Figures, 36 References. Adapted from the source document JF - Journal of Cognitive Neuroscience AU - Milberg, William AU - Blumstein, Sheila E AU - Katz, Donald AU - Gershberg, Felicia AU - Brown, Todd AD - GRECC Veterans Administration Medical Center, 1400 VFW Parkway West Roxbury MA 02132 Y1 - 1995/01// PY - 1995 DA - January 1995 SP - 33 EP - 50 VL - 7 IS - 1 SN - 0898-929X, 0898-929X KW - Broca's/Wernicke's aphasics' lexical access deficits characterization, automatic-controlled processing dichotomy use KW - time, expectancy KW - auditory lexical decision semantic priming experiments KW - aphasics aged 43-78, normal controls KW - Time (89850) KW - Aphasia (03400) KW - Language Pathology (43250) KW - Brocas Aphasia (09750) KW - Semantic Processing (76760) KW - Wernickes Aphasia (96250) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85618637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cognitive+Neuroscience&rft.atitle=Semantic+Facilitation+in+Aphasia%3A+Effects+of+Time+and+Expectancy&rft.au=Milberg%2C+William%3BBlumstein%2C+Sheila+E%3BKatz%2C+Donald%3BGershberg%2C+Felicia%3BBrown%2C+Todd&rft.aulast=Milberg&rft.aufirst=William&rft.date=1995-01-01&rft.volume=7&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cognitive+Neuroscience&rft.issn=0898929X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCONEO N1 - SubjectsTermNotLitGenreText - Language Pathology (43250); Aphasia (03400); Wernickes Aphasia (96250); Brocas Aphasia (09750); Semantic Processing (76760); Time (89850) ER - TY - JOUR T1 - Adenocarcinoma arising in an inlet patch of the esophagus. AN - 85230325; pmid-7801922 JF - The American Journal of Gastroenterology AU - Sperling, R M AU - Grendell, J H AD - San Francisco Veterans Administration Medical Center, California. PY - 1995 SP - 150 EP - 152 VL - 90 IS - 1 SN - 0002-9270, 0002-9270 KW - Human KW - Aged KW - Case Report KW - Constriction, Pathologic KW - Male KW - Esophageal Neoplasms KW - Adenocarcinoma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85230325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Adenocarcinoma+arising+in+an+inlet+patch+of+the+esophagus.&rft.au=Sperling%2C+R+M%3BGrendell%2C+J+H&rft.aulast=Sperling&rft.aufirst=R&rft.date=1995-01-01&rft.volume=90&rft.issue=1&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Prolonged benign pneumoperitoneum after percutaneous endoscopic gastrostomy. AN - 85229085; pmid-7801919 JF - The American Journal of Gastroenterology AU - Thirumahilmaran, S AU - Patel, N AU - Thomas, E AD - Department of Internal Medicine, Veterans Administration Medical Center, Johnson City, Tennessee. PY - 1995 SP - 147 EP - 148 VL - 90 IS - 1 SN - 0002-9270, 0002-9270 KW - Gastrostomy KW - Gastroscopy KW - Human KW - Aged KW - Case Report KW - Pneumoperitoneum KW - Time Factors KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85229085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Prolonged+benign+pneumoperitoneum+after+percutaneous+endoscopic+gastrostomy.&rft.au=Thirumahilmaran%2C+S%3BPatel%2C+N%3BThomas%2C+E&rft.aulast=Thirumahilmaran&rft.aufirst=S&rft.date=1995-01-01&rft.volume=90&rft.issue=1&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Clozapine therapy in patients with neurologic illness. AN - 77929062; 8822385 AB - This review will analyze the use of clozapine in patients with neurologic illness. A review of the literature was performed. Attention is focused particularly on patients with seizure disorder, head injury, mental retardation, Parkinson's disease, Huntington's disease, tardive dyskinesia, and selected other neurological disorders. This review discusses clinical difficulties/issues associated with clozapine therapy in patients with a variety of neurological disorders. Although clozapine therapy should be reserved for those patients who are refractory to conventional psychotropic medications, when used appropriately it may offer a safe and effective way of improving quality of life for patients with behavioral symptoms and neurologic illness. JF - International journal of psychiatry in medicine AU - Sajatovic, M AU - Ramirez, L AD - Cleveland Veterans Administration Medical Center, Brecksville, OH 44141, USA. Y1 - 1995 PY - 1995 DA - 1995 SP - 331 EP - 344 VL - 25 IS - 4 SN - 0091-2174, 0091-2174 KW - Antipsychotic Agents KW - 0 KW - Clozapine KW - J60AR2IKIC KW - Index Medicus KW - Humans KW - Treatment Outcome KW - Quality of Life KW - Nervous System Diseases -- drug therapy KW - Clozapine -- therapeutic use KW - Nervous System Diseases -- etiology KW - Antipsychotic Agents -- therapeutic use KW - Clozapine -- adverse effects KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77929062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+psychiatry+in+medicine&rft.atitle=Clozapine+therapy+in+patients+with+neurologic+illness.&rft.au=Sajatovic%2C+M%3BRamirez%2C+L&rft.aulast=Sajatovic&rft.aufirst=M&rft.date=1995-01-01&rft.volume=25&rft.issue=4&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=International+journal+of+psychiatry+in+medicine&rft.issn=00912174&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-11-15 N1 - Date created - 1996-11-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Absorption of iron dextran from the peritoneal cavity of rats. AN - 77733399; 8534738 AB - We investigated the absorption rate and acute toxicities of intraperitoneal iron dextran in rats. Eighteen Sprague-Dawley rats were divided into three groups (n = 6). The animals were given standard 1.5% Dianeal (group 1) or 1.5% Dianeal containing iron in a concentration of 2 mg/L (group 2) or 10 mg/L (group 3) as iron dextran. First, a predialysis blood sample was obtained, and 25 mL of the designated dialysis solution was instilled into the peritoneal cavity. After a 6-hour cycle the dialysate was drained, and a postdialysis blood sample and specimen of the peritoneum were obtained. The iron concentrations of the dialysis solution, the dialysate, and both serum samples were determined. Histological samples were processed by hematoxylin and eosin and Prussian blue stain. Results of the iron concentration (mg/L) of the dialysis solution, the dialysate, and the percent of the absorbed iron were as follows: group 1: 0.00, 0.20 +/- 0.15, N/A; group 2: 2.24, 0.66 +/- 2.8, 73.8 +/- 11.0; group 3: 9.84, 2.12 +/- 0.62, 80.8 +/- 5.7. The serum iron concentration did not change. No abnormal findings were found histologically. More than 70% of the iron dextran was absorbed from the peritoneal cavity of the rats during a 6-hour peritoneal dialysis exchange. Intraperitoneal iron dextran may be an alternative route of iron delivery. JF - Advances in peritoneal dialysis. Conference on Peritoneal Dialysis AU - Suzuki, K AU - Twardowski, Z J AU - Nolph, K D AU - Khanna, R AU - Moore, H L AD - Department of Medicine, Harry S. Truman Veterans Administration Hospital, Columbia, Missouri, USA. Y1 - 1995 PY - 1995 DA - 1995 SP - 57 EP - 59 VL - 11 SN - 1197-8554, 1197-8554 KW - Iron-Dextran Complex KW - 9004-66-4 KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Peritoneum -- drug effects KW - Absorption KW - Iron -- blood KW - Male KW - Peritoneal Cavity KW - Peritoneal Dialysis KW - Iron-Dextran Complex -- toxicity KW - Iron-Dextran Complex -- administration & dosage KW - Iron-Dextran Complex -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77733399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+peritoneal+dialysis.+Conference+on+Peritoneal+Dialysis&rft.atitle=Absorption+of+iron+dextran+from+the+peritoneal+cavity+of+rats.&rft.au=Suzuki%2C+K%3BTwardowski%2C+Z+J%3BNolph%2C+K+D%3BKhanna%2C+R%3BMoore%2C+H+L&rft.aulast=Suzuki&rft.aufirst=K&rft.date=1995-01-01&rft.volume=11&rft.issue=&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Advances+in+peritoneal+dialysis.+Conference+on+Peritoneal+Dialysis&rft.issn=11978554&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1996-02-02 N1 - Date created - 1996-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Type XI and II collagen-induced arthritis in rats: characterization of inbred strains of rats for arthritis-susceptibility and immune-responsiveness to type XI and II collagen. AN - 77726938; 7578876 AB - To determine the relationship between susceptibility to bovine type XI and II (BXI and BII) collagen-induced arthritis, we immunized 14 inbred and one outbred strains of rats with BXI and BII. Susceptibility to BXI-arthritis corresponded largely with susceptibility, or resistance, to BII-arthritis. LEW, BB, WF, DA, and WKY were readily susceptible to BXI- and BII-arthritis. Likewise, BII-resistant F344 and BN rats were BXI-resistant. Some strains responded differently to BXI and BII. BUF and COP, which are moderately susceptible to BII, were BXI-resistant, whereas the BII-resistant rats, DA.1N and WF.1N, were partially susceptible to BXI. (F344 x BN) F1 hybrids responded to both collagens suggesting gene complementation. Arthritis occurred in all strains producing the highest titer antisera (LEW, WF and BB). Antibody responses to BXI and BII were generally commensurate within individual strains. DA were susceptible to arthritis but produced low levels of antibody comparable to BN rats which were arthritis-resistant. BXI and BII-susceptibility was variable in rats producing intermediate antibody responses. Antibodies to RXI were detected in all BXI-immunized rats, whereas antibodies to RV and RII were uniformly weaker. DTH to RXI and RII was strong in both groups of rats, correlating poorly with arthritis and antibody responses. These studies show that phenotypic susceptibility to BXI- and BII-arthritis are largely concordant among inbred rat strains but clear differences exist in certain strains; multiple genes are likely involved. JF - Autoimmunity AU - Cremer, M A AU - Griffiths, M M AU - Terato, K AU - Kang, A H AD - Research Service, Veterans Administration Medical Center, University of Tennessee, Memphis 38104, USA. Y1 - 1995 PY - 1995 DA - 1995 SP - 153 EP - 161 VL - 20 IS - 3 SN - 0891-6934, 0891-6934 KW - Collagen KW - 9007-34-5 KW - Index Medicus KW - Animals KW - Rats, Inbred Lew KW - Rats, Inbred WKY KW - Antibody Formation KW - Disease Susceptibility -- immunology KW - Rats, Inbred ACI KW - Rats, Inbred BN KW - Rats, Inbred BUF KW - Hypersensitivity, Delayed -- immunology KW - Rats KW - Rats, Inbred F344 KW - Immunity, Cellular KW - Rats, Inbred WF KW - Rats, Wistar KW - Genetic Predisposition to Disease KW - Species Specificity KW - Female KW - Male KW - Arthritis -- genetics KW - Collagen -- immunology KW - Arthritis -- immunology KW - Arthritis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77726938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Autoimmunity&rft.atitle=Type+XI+and+II+collagen-induced+arthritis+in+rats%3A+characterization+of+inbred+strains+of+rats+for+arthritis-susceptibility+and+immune-responsiveness+to+type+XI+and+II+collagen.&rft.au=Cremer%2C+M+A%3BGriffiths%2C+M+M%3BTerato%2C+K%3BKang%2C+A+H&rft.aulast=Cremer&rft.aufirst=M&rft.date=1995-01-01&rft.volume=20&rft.issue=3&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Autoimmunity&rft.issn=08916934&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-12-26 N1 - Date created - 1995-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Atypical apoptotic cell death induced in L929 targets by exposure to tumor necrosis factor. AN - 77462783; 7648436 AB - The mechanism by which tumor necrosis factor (TNF) induces cytotoxicity of murine fibroblasts was investigated. Electrophoresis of DNA extracted from TNF-treated L929 targets showed fragmentation of DNA into a ladder-like pattern, typical of cells dying by apoptosis. Morphologic analysis also indicated apoptotic cell death, demonstrating clumping and crescentic condensation of chromatin. In contrast, chromatin condensation and ladder-like DNA fragmentation were not detected in L929 targets dying by necrosis from exposure to heat, repeated cycles of freeze-thaw, and sodium azide. Chromatin condensation was an early event, detected as early as 6 h of incubation. However, DNA fragmentation (assayed by double-stranded fragmentation assay and gel electrophoresis), as well as the apoptotic changes detected by Hoechst fluorescence, both occurred later and did not precede TNF cytotoxicity (membrane permeabilization detected by trypan blue or propidium iodide staining). This atypical pattern of apoptosis was a characteristic of L929 target cells rather than a generalized cytotoxic response to TNF because TNF-treated squamous cancer cells showed typical features of apoptosis (DNA fragmentation before cytotoxicity) and etoposide-treated L929 cells demonstrated the same atypical kinetics as TNF-treated cells. Zinc significantly inhibited TNF cytotoxicity as well as DNA fragmentation of L929. However, because DNA fragmentation occurred belatedly in TNF-treated targets, lagging behind cytotoxicity, the protection by zinc against TNF appears mediated by events that occur before the ultimate endonuclease-induced cleavage of DNA into small fragments. JF - Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research AU - Fady, C AU - Gardner, A AU - Jacoby, F AU - Briskin, K AU - Tu, Y AU - Schmid, I AU - Lichtenstein, A AD - Department of Medicine, Veterans Administration Wadsworth-University of California, Los Angeles Medical Center 90073, USA. Y1 - 1995/01// PY - 1995 DA - January 1995 SP - 71 EP - 80 VL - 15 IS - 1 SN - 1079-9907, 1079-9907 KW - Herpes Simplex Virus Protein Vmw65 KW - 0 KW - Tumor Necrosis Factor-alpha KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Animals KW - Zinc -- pharmacology KW - Tumor Cells, Cultured KW - Kinetics KW - Herpes Simplex Virus Protein Vmw65 -- pharmacology KW - Mice KW - Cell Line KW - Tumor Necrosis Factor-alpha -- toxicity KW - Apoptosis -- drug effects KW - Tumor Necrosis Factor-alpha -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77462783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+interferon+%26+cytokine+research+%3A+the+official+journal+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.atitle=Atypical+apoptotic+cell+death+induced+in+L929+targets+by+exposure+to+tumor+necrosis+factor.&rft.au=Fady%2C+C%3BGardner%2C+A%3BJacoby%2C+F%3BBriskin%2C+K%3BTu%2C+Y%3BSchmid%2C+I%3BLichtenstein%2C+A&rft.aulast=Fady&rft.aufirst=C&rft.date=1995-01-01&rft.volume=15&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Journal+of+interferon+%26+cytokine+research+%3A+the+official+journal+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.issn=10799907&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-09-28 N1 - Date created - 1995-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Localization of epidermal sphingolipid synthesis and serine palmitoyl transferase activity: alterations imposed by permeability barrier requirements. AN - 77359923; 7598529 AB - Sphingolipids, the predominant lipid species in mammalian stratum corneum play, a central role in permeability barrier homeostatis. Prior studies have shown that the epidermis synthesizes abundant sphingolipids, a process regulated by barrier requirements, and that inhibition of sphingolipid synthesis interferes with barrier homeostasis. To investigate further the relationship between epidermal sphingolipid metabolism and barrier function, we localized sphingolipid synthetic activity in murine epidermis under basal conditions, and following acute (acetone treatment) or chronic (essential fatty acid deficiency, EFAD) barrier perturbation, using dithiothreitol and/or the staphylococcal epidermolytic toxin to isolate the lower from the outer epidermis. Under basal conditions, both the activity of serine palmitoyl transferase (SPT), the rate-limiting enzyme of sphingolipid synthesis, and the rates of 3H-H2O incorporation into sphingolipids were nearly equivalent in the lower and the outer epidermis. Following acute barrier perturbation, SPT activity increased significantly in both the lower (35%; P < 0.05) and the outer epidermal layers (60%; P < 0.01). The rates of 3H-H2O incorporation into each major sphingolipid family, including ceramides, glucosylceramides and sphingomyelin, increased significantly in both the lower and the outer epidermis of treated flanks after acute barrier disruption. Finally, SPT activity was modestly elevated (20%; P < 0.01) in the lower but not in the outer epidermis of EFAD animals. These studies demonstrate the ability of both lower and outer epidermal cells to generate sphingolipids, and that permeability barrier homeostatic mechanisms appear to differentially regulate SPT activity and sphingolipid synthesis in the lower and the outer epidermis in response to acute and chronic barrier perturbation.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Archives of dermatological research AU - Holleran, W M AU - Gao, W N AU - Feingold, K R AU - Elias, P M AD - Dermatology Service, Veterans Administration Medical Center, San Francisco, CA 94121, USA. Y1 - 1995 PY - 1995 DA - 1995 SP - 254 EP - 258 VL - 287 IS - 3-4 SN - 0340-3696, 0340-3696 KW - Fatty Acids, Essential KW - 0 KW - Sphingolipids KW - Acetone KW - 1364PS73AF KW - Cholesterol KW - 97C5T2UQ7J KW - Acyltransferases KW - EC 2.3.- KW - Serine C-Palmitoyltransferase KW - EC 2.3.1.50 KW - Sptlc1 protein, mouse KW - Index Medicus KW - Permeability -- drug effects KW - Animals KW - Fatty Acids, Essential -- deficiency KW - Cholesterol -- biosynthesis KW - Mice KW - Mice, Hairless KW - Homeostasis KW - Male KW - Acetone -- toxicity KW - Epidermis -- drug effects KW - Epidermis -- metabolism KW - Sphingolipids -- biosynthesis KW - Acyltransferases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77359923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+dermatological+research&rft.atitle=Localization+of+epidermal+sphingolipid+synthesis+and+serine+palmitoyl+transferase+activity%3A+alterations+imposed+by+permeability+barrier+requirements.&rft.au=Holleran%2C+W+M%3BGao%2C+W+N%3BFeingold%2C+K+R%3BElias%2C+P+M&rft.aulast=Holleran&rft.aufirst=W&rft.date=1995-01-01&rft.volume=287&rft.issue=3-4&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Archives+of+dermatological+research&rft.issn=03403696&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-08-03 N1 - Date created - 1995-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effect of aluminum on the vanadium-mediated oxidation of NADH. AN - 77173165; 7891795 AB - Aluminum catalyzes the oxidation of NADH by vanadate both in the presence and absence of a reducing sugar. The effect of aluminum is concentration dependent and inhibitable with superoxide dismutase but not catalase. The fructose-6-phosphate-free reaction is characterized by an initial lag phase which can be eliminated by preincubating aluminum with NADH, but is not altered by preincubating aluminum with vanadate, suggesting that the effect of aluminum is not directly on vanadate. Aluminum also catalyzes vanadyl-mediated oxidation of NADH, and this effect is similarly inhibitable by superoxide dismutase as well as catalase. It is suggested that aluminum catalyzes the oxidation of NADH by vanadium though enhancing the production of superoxide radicals and that this effect may account in part of the biological toxicity associated with aluminum, particularly when associated with the accumulation of other trace elements such as vanadium. JF - Nephron AU - Adler, A J AU - Caruso, C AU - Berlyne, G M AD - Brooklyn Veterans Administration Medical Center, NY 11203. Y1 - 1995 PY - 1995 DA - 1995 SP - 34 EP - 40 VL - 69 IS - 1 SN - 1660-8151, 1660-8151 KW - Fructosephosphates KW - 0 KW - Reactive Oxygen Species KW - Vanadium Compounds KW - Vanadium KW - 00J9J9XKDE KW - NAD KW - 0U46U6E8UK KW - Vanadates KW - 3WHH0066W5 KW - fructose-6-phosphate KW - 6814-87-5 KW - vanadyl sulfate KW - 6DU9Y533FA KW - Hydrogen Peroxide KW - BBX060AN9V KW - Aluminum KW - CPD4NFA903 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Index Medicus KW - Vanadium Compounds -- chemistry KW - Animals KW - Reactive Oxygen Species -- metabolism KW - Drug Interactions KW - Fructosephosphates -- antagonists & inhibitors KW - Fructosephosphates -- chemistry KW - Vanadates -- pharmacology KW - Reactive Oxygen Species -- chemistry KW - Vanadates -- antagonists & inhibitors KW - Oxidation-Reduction KW - Fructosephosphates -- pharmacology KW - Cattle KW - Superoxide Dismutase -- chemistry KW - Hydrogen Peroxide -- chemistry KW - NAD -- chemistry KW - NAD -- metabolism KW - Aluminum -- metabolism KW - Aluminum -- chemistry KW - Aluminum -- toxicity KW - Vanadium -- metabolism KW - Vanadium -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77173165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nephron&rft.atitle=The+effect+of+aluminum+on+the+vanadium-mediated+oxidation+of+NADH.&rft.au=Adler%2C+A+J%3BCaruso%2C+C%3BBerlyne%2C+G+M&rft.aulast=Adler&rft.aufirst=A&rft.date=1995-01-01&rft.volume=69&rft.issue=1&rft.spage=34&rft.isbn=&rft.btitle=&rft.title=Nephron&rft.issn=16608151&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-04-18 N1 - Date created - 1995-04-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determinants of longitudinal changes in spirometric function among swine confinement operators and farmers. AN - 77121121; 7812571 AB - To assess whether working in a swine confinement facility causes an excess or accelerated decline in lung function, we conducted a population-based study to evaluate the determinants of longitudinal changes in airflow in a population of swine confinement operators. Spirometric measures of lung function were compared between swine confinement operators (N = 168) and neighborhood farmer control subjects (N = 127). Study subjects were randomly selected from a cohort of swine confinement operators in eastern Iowa. The control farming population was matched by geographic location, age, and sex to the swine confinement operators. On average, the follow-up time was approximately 2 yr, with a range of follow-up between 56 and 1,900 d. Although swine confinement operators and neighborhood farmers had similar demographic characteristics (age, gender, racial background, smoking history, and atopy status), swine confinement operators tended to have less farming experience and were more extensively followed (more measures of lung function and longer periods of observation) than the neighborhood farmer control group. Swine confinement operators were also exposed to higher environmental dust concentrations and other irritants than the farmer control subjects. Interestingly, the cross-sectional data indicated that swine confinement operators tended to have slightly lower measures of airflow and greater workshift declines in forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and mid-expiratory flow (FEF25-75) than the neighborhood farmer control group.(ABSTRACT TRUNCATED AT 250 WORDS) JF - American journal of respiratory and critical care medicine AU - Schwartz, D A AU - Donham, K J AU - Olenchock, S A AU - Popendorf, W J AU - Van Fossen, D S AU - Burmeister, L F AU - Merchant, J A AD - Department of Preventive Medicine, U.S. Department of Veterans Administration Medical Center, Iowa City, Iowa. Y1 - 1995/01// PY - 1995 DA - January 1995 SP - 47 EP - 53 VL - 151 IS - 1 SN - 1073-449X, 1073-449X KW - Abridged Index Medicus KW - Index Medicus KW - Swine KW - Regression Analysis KW - Animals KW - Random Allocation KW - Humans KW - Animal Husbandry -- statistics & numerical data KW - Adult KW - Spirometry -- statistics & numerical data KW - Middle Aged KW - Longitudinal Studies KW - Male KW - Iowa -- epidemiology KW - Female KW - Occupational Exposure -- statistics & numerical data KW - Lung Diseases -- diagnosis KW - Agricultural Workers' Diseases -- epidemiology KW - Agricultural Workers' Diseases -- diagnosis KW - Agricultural Workers' Diseases -- physiopathology KW - Occupational Exposure -- adverse effects KW - Lung Diseases -- physiopathology KW - Lung Diseases -- epidemiology KW - Lung -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77121121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Determinants+of+longitudinal+changes+in+spirometric+function+among+swine+confinement+operators+and+farmers.&rft.au=Schwartz%2C+D+A%3BDonham%2C+K+J%3BOlenchock%2C+S+A%3BPopendorf%2C+W+J%3BVan+Fossen%2C+D+S%3BBurmeister%2C+L+F%3BMerchant%2C+J+A&rft.aulast=Schwartz&rft.aufirst=D&rft.date=1995-01-01&rft.volume=151&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-02-09 N1 - Date created - 1995-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Current status of thrombolysis in acute myocardial infarction. I. Optimal selection and delivery of a thrombolytic drug. AN - 77115773; 7813283 JF - Chest AU - Habib, G B AD - Department of Medicine, Veterans Administration Medical Center, Houston. Y1 - 1995/01// PY - 1995 DA - January 1995 SP - 225 EP - 232 VL - 107 IS - 1 SN - 0012-3692, 0012-3692 KW - Anistreplase KW - 81669-57-0 KW - Streptokinase KW - EC 3.4.- KW - Tissue Plasminogen Activator KW - EC 3.4.21.68 KW - Abridged Index Medicus KW - Index Medicus KW - Tissue Plasminogen Activator -- therapeutic use KW - Anistreplase -- therapeutic use KW - Humans KW - Streptokinase -- therapeutic use KW - Thrombolytic Therapy -- adverse effects KW - Myocardial Infarction -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77115773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Current+status+of+thrombolysis+in+acute+myocardial+infarction.+I.+Optimal+selection+and+delivery+of+a+thrombolytic+drug.&rft.au=Habib%2C+G+B&rft.aulast=Habib&rft.aufirst=G&rft.date=1995-01-01&rft.volume=107&rft.issue=1&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-02-07 N1 - Date created - 1995-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Problem of Auditory Hallucinations in Combat PTSD AN - 759313488; 13617109 AB - In a study of 115 combat veterans with post-traumatic stress disorder, the majority (65%) reported hearing voices. These dissociative voices included command hallucinations to which the individuals responded with a feeling of automatic obedience. We describe an evolving series of psychological interventions that appear to diminish dissociation. These techniques teach the patient to objectively clarify, to conduct a dialogue with, and to negotiate with their voices.[1882 words] JF - Traumatology AU - Holmes, Douglas S AU - Tinnin, Louis W AD - The Louis A. Johnson Veterans Administration Medical Center, Clarksburg, West Virginia, and West Virginia University, Morgantown , West Virginia Y1 - 1995 PY - 1995 DA - 1995 SP - 1 EP - 7 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 1 IS - 2 SN - 1534-7656, 1534-7656 KW - Health & Safety Science Abstracts KW - posttraumatic stress disorder KW - Psychology KW - intervention KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759313488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traumatology&rft.atitle=The+Problem+of+Auditory+Hallucinations+in+Combat+PTSD&rft.au=Holmes%2C+Douglas+S%3BTinnin%2C+Louis+W&rft.aulast=Holmes&rft.aufirst=Douglas&rft.date=1995-01-01&rft.volume=1&rft.issue=2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Traumatology&rft.issn=15347656&rft_id=info:doi/10.1177%2F153476569500100201 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - posttraumatic stress disorder; Psychology; intervention DO - http://dx.doi.org/10.1177/153476569500100201 ER - TY - JOUR T1 - Attempted Suicide among Vietnam Veterans: A Model of Etiology in a Community Sample AN - 61626638; 199501403 AB - An etiological model of attempted suicide among Vietnam veterans was developed using national survey data collected 1986-1988 from a community sample of 1,198 veterans. Psychiatric disorder was the only factor found to directly relate to attempted suicide, though other factors, ie, participation in wartime atrocities, experience of nonmilitary trauma during military service, & premilitary family instability, were associated with incidence of psychiatric disorder. Exposure to combat, participation in atrocities, Hispanic ethnicity, low levels of support, & rejecting welcome after returning home were associated with posttraumatic stress disorder, which, along with substance abuse, was associated with attempted suicide, though not independently of psychiatric disorder. 3 Tables, 1 Figure, 39 References. Adapted from the source document. JF - The American Journal of Psychiatry AU - Fontana, Alan AU - Rosenheck, Robert AD - Northeast Program Evaluation Center Veterans Administration Medical Center, 950 Campbell Ave West Haven CT 06516 Y1 - 1995/01// PY - 1995 DA - January 1995 SP - 102 EP - 109 VL - 152 IS - 1 SN - 0002-953X, 0002-953X KW - attempted suicide, Vietnam veterans, etiological model KW - 1986-1988 national survey KW - Veterans KW - Etiology KW - Vietnam War KW - Suicide KW - Risk Assessment KW - article KW - 6144: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61626638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Attempted+Suicide+among+Vietnam+Veterans%3A+A+Model+of+Etiology+in+a+Community+Sample&rft.au=Fontana%2C+Alan%3BRosenheck%2C+Robert&rft.aulast=Fontana&rft.aufirst=Alan&rft.date=1995-01-01&rft.volume=152&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Vietnam War; Veterans; Suicide; Etiology; Risk Assessment ER - TY - JOUR T1 - Assessing the Implementation of a Case Management Intervention for the Homeless AN - 61423523; 9610187 AB - Describes some of the key characteristics of the implementation of a 1-year clinical case management intervention for 178 homeless veterans with substance abuse &/or psychiatric disorders, which consisted of up to 6 months of residential care with the balance being follow-up case management. Customary Veterans Administration services provided to a randomly assigned control group of 180 Ss were also assessed. Services intended, delivered, & received were evaluated using performance measurements & continuous quality indicators. Results confirm that the implementation was successful in 5 of 7 indicators in delivering the intended services based on the original program design. 4 Tables, 8 Figures, 13 References. Adapted from the source document. JF - Advances in Medical Sociology AU - Hultman, Cheryl I AU - Conrad, Kendon J AU - Pope, Annie R AU - Baxter, William C AU - Lisiecki, Joe AU - Elbaum, Phil AD - Midwest Center Health Services & Policy Research Hines Veterans Administration Medical Center, IL 60141 Y1 - 1995///0, PY - 1995 DA - 0, 1995 SP - 295 EP - 323 VL - 6 KW - case management intervention, homeless veterans with substance abuse/psychiatric disorders KW - empirical data KW - Veterans KW - Health Services KW - Substance Abuse KW - Delivery Systems KW - Social Services KW - Intervention KW - Residential Institutions KW - Mental Illness KW - Homelessness KW - article KW - 2187: social problems and social welfare; social service programs/delivery systems KW - 2793: studies in poverty; homelessness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61423523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+Medical+Sociology&rft.atitle=Assessing+the+Implementation+of+a+Case+Management+Intervention+for+the+Homeless&rft.au=Hultman%2C+Cheryl+I%3BConrad%2C+Kendon+J%3BPope%2C+Annie+R%3BBaxter%2C+William+C%3BLisiecki%2C+Joe%3BElbaum%2C+Phil&rft.aulast=Hultman&rft.aufirst=Cheryl&rft.date=1995-01-01&rft.volume=6&rft.issue=&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Advances+in+Medical+Sociology&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AMSOEI N1 - SubjectsTermNotLitGenreText - Homelessness; Veterans; Substance Abuse; Mental Illness; Social Services; Health Services; Delivery Systems; Residential Institutions; Intervention ER - TY - JOUR T1 - Recognition and Judgment of Facial Stimuli in Schizotypal Subjects AN - 58235070; 9512188 AB - A study exploring facial affect recognition (facial expression /reaction necessary in social functioning) by schizotypal & control Ss (N = 68 & 40, respectively). Ss viewed photographs depicting various facial expressions & rated them according to affects such as "happiness" & "unpleasantness." Ss also completed the Shipley Instit of Living Scale. Results do not support a hypothesis that impairment of facial affect recognition is a manifestation of all schizophrenia stages, but rather it is suggested that defects in emotional decoding may appear at a relatively late stage in the development of the disorder, or it may be associated with more severe levels of schizophrenia-spectrum symptomology. 1 Table, 45 References. Adapted from the source document JF - Journal of Communication Disorders AU - Toomey, Rosemary AU - Schuldberg, David AD - Psychiatry Service Brockton/West Roxbury Veterans Administration Medical Center 940 Belmont St Brockton MA 02401 Y1 - 1995///0, PY - 1995 DA - 0, 1995 SP - 193 EP - 203 VL - 28 IS - 3 SN - 0021-9924, 0021-9924 KW - facial emotions recognition, schizotypal/control subjects KW - empirical data KW - Emotions (21600) KW - Schizophrenia (75250) KW - Psychometric Analysis (69210) KW - Facial Expressions (23700) KW - article KW - 5810: nonverbal communication; human nonverbal language UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58235070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Communication+Disorders&rft.atitle=Recognition+and+Judgment+of+Facial+Stimuli+in+Schizotypal+Subjects&rft.au=Toomey%2C+Rosemary%3BSchuldberg%2C+David&rft.aulast=Toomey&rft.aufirst=Rosemary&rft.date=1995-01-01&rft.volume=28&rft.issue=3&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Journal+of+Communication+Disorders&rft.issn=00219924&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCDIAI N1 - SubjectsTermNotLitGenreText - Schizophrenia (75250); Facial Expressions (23700); Emotions (21600); Psychometric Analysis (69210) ER - TY - JOUR T1 - Policies and Services in Residential Substance Abuse Programs: Comparisons with Psychiatric Programs AN - 1761709458; 199603872 AB - Describes the Policy & Service Characteristics Inventory (PASCI), which assesses the policies & services of hospital- & community-based substance abuse & psychiatric residential programs for adults. Developed using data from 96 representative programs, the PASCI has 9 dimensions that have good internal consistency & are relatively independent & quite stable. In comparison to psychiatric programs (N = 43), substance abuse programs (N = 53): had more restrictive admissions policies & were less tolerant of problematic resident behavior; provided less individual choice & privacy, but more formal structures for resident control & policy clarity; & offered less daily living assistance. Compared to community-based substance abuse programs, hospital-based programs: had less restrictive admissions policies; provided residents with less choice & control, but more policy clarity; & offered more health, treatment, & social recreation services. The PASCI dimensions were related to substance abuse programs' organizational features -- eg, size & staffing -- & to program-level outcomes -- eg, the proportion of patients who successfully complete the program. Potential applications of the PASCI & the full inventory of which it is a part are discussed. 4 Tables, 1 Figure, 24 References. Adapted from the source document. JF - Journal of Substance Abuse AU - Timko, Christine AD - Veterans Administration Medical Center, 3801 Miranda Ave Palo Alto CA 94304 Y1 - 1995///0, PY - 1995 DA - 0, 1995 SP - 43 EP - 59 VL - 7 IS - 1 SN - 0899-3289, 0899-3289 KW - hospital-/community-based substance abuse/psychiatric residential programs, policies/services KW - Policy & Service Characteristics Inventory KW - Substance Abuse KW - Treatment Programs KW - Institutionalization (Persons) KW - Residential Institutions KW - Community Services KW - Mental Hospitals KW - Mental Illness KW - Hospitals KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761709458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse&rft.atitle=Policies+and+Services+in+Residential+Substance+Abuse+Programs%3A+Comparisons+with+Psychiatric+Programs&rft.au=Timko%2C+Christine&rft.aulast=Timko&rft.aufirst=Christine&rft.date=1995-01-01&rft.volume=7&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse&rft.issn=08993289&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Substance Abuse; Mental Illness; Institutionalization (Persons); Residential Institutions; Treatment Programs; Community Services; Mental Hospitals; Hospitals ER - TY - JOUR T1 - DSM-III-R Alcohol Dependence Criteria in Russian and American Men AN - 1761707566; 199604293 AB - Data on the alcohol drinking patterns of US & Russian men currently enrolled in alcohol treatment programs are described in terms of quantity of alcohol consumed, patterns of alcohol use, withdrawal symptoms, & biopsychological problems experienced. Using DSM-III-R criteria to determine alcohol dependence diagnoses as measured by the CIDI-SAM (Composite International Diagnostic Interview-Substance Abuse Module), it is shown that 99% of the US & 97% of the Russian sample met DSM-III-R dependence criteria. In general, these data offer some validity for use of the DSM-III-R criteria & CIDI-SAM to determine alcohol dependence in a Russian sample. Although differences in the patterns & symptoms of alcohol use were found, they may be reflective of cultural, social, & economic factors, in addition to methodological limitations. Adapted from the source document. JF - Journal of Substance Abuse AU - Zanis, David A AU - McLellan, A Thomas AU - Cacciola, John AU - Vrublevski, Andrey AD - Philadelphia Veterans Administration Medical Center, University & Woodland Aves PA 19104 Y1 - 1995///0, PY - 1995 DA - 0, 1995 SP - 253 EP - 261 VL - 7 IS - 2 SN - 0899-3289, 0899-3289 KW - DSM-III alcohol dependence criteria/validity, US/Russian men KW - alcohol use patterns/symptoms data KW - Diagnosis KW - Males KW - Alcoholism KW - Alcohol Use KW - United States of America KW - Russia KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761707566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse&rft.atitle=DSM-III-R+Alcohol+Dependence+Criteria+in+Russian+and+American+Men&rft.au=Zanis%2C+David+A%3BMcLellan%2C+A+Thomas%3BCacciola%2C+John%3BVrublevski%2C+Andrey&rft.aulast=Zanis&rft.aufirst=David&rft.date=1995-01-01&rft.volume=7&rft.issue=2&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse&rft.issn=08993289&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Alcohol Use; Alcoholism; Diagnosis; Russia; United States of America; Males ER - TY - JOUR T1 - An Impact Evaluation of a VA Geriatric Team Development Program AN - 1761702362; 199604057 AB - Describes the results of using a variety of evaluation methods, both quantitative & qualitative, to measure the long-term outcomes of a 4-year series of workshops designed to teach Veterans Administration employees of various disciplines the value of teamwork & consultation in caring for geriatric veterans. Implications of this impact evaluation that may be useful to education program planners & evaluators are presented. 12 References. Adapted from the source document. JF - Gerontology & Geriatrics Education AU - Walsh, Patrick L AU - Garbs, Carol A AU - Goodwin, Marsha AU - Wolff, Eliza M AD - Learning Resources Service Veterans Administration Medical Center, Salt Lake City UT 84148 Y1 - 1995///0, PY - 1995 DA - 0, 1995 SP - 19 EP - 35 VL - 15 IS - 3 SN - 0270-1960, 0270-1960 KW - employee teamwork/consultation training, Veterans Administration geriatic team, evaluation methods KW - Health Professions KW - Workshops (Courses) KW - Teamwork KW - Geriatrics KW - Program Evaluation KW - Job Training KW - article KW - 7220: evaluation research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761702362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gerontology+%26+Geriatrics+Education&rft.atitle=An+Impact+Evaluation+of+a+VA+Geriatric+Team+Development+Program&rft.au=Walsh%2C+Patrick+L%3BGarbs%2C+Carol+A%3BGoodwin%2C+Marsha%3BWolff%2C+Eliza+M&rft.aulast=Walsh&rft.aufirst=Patrick&rft.date=1995-01-01&rft.volume=15&rft.issue=3&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Gerontology+%26+Geriatrics+Education&rft.issn=02701960&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Program Evaluation; Teamwork; Health Professions; Geriatrics; Job Training; Workshops (Courses) ER - TY - JOUR T1 - MR VS CT in progressive supranuclear palsy AN - 15701304; 203640 AB - Nine progressive supranuclear palsy (PSP) patients were studied with computerized tomography (CT) and magnetic resonance (MR) in order to determine the efficacy of each in detecting atrophy of the brainstem. Three additional PSP patients were evaluated with MRI for quantitative (electronic) measurements of the colliculi, pons and midbrain tegmentum. Both CT and MRI were equally effective in demonstrating midbrain atrophy. The MR was able to utilize the sagittal view to visualize thinning of the collicular (quadrigeminal) plate, a useful sign in PSP. Atrophy of the thinned collicular plate is more pronounced in the superior colliculus, one of the most common sites of pathology in PSP. The MR is able to make quantitative measurements of the degree of atrophy of the colliculi, pons and midbrain tegmentum. JF - Computerized Medical Imaging and Graphics AU - Masucci, Elmo F AU - Borts, Frederick T AU - Perl, Stanley M AU - Wener, Louis AU - Schwankhaus, John AU - Kurtzke, John F AD - Veterans Administration Medical Cent, Washington, DC, USA Y1 - 1995 PY - 1995 DA - 1995 SP - 361 EP - 368 PB - PERGAMON PRESS INC, TARRYTOWN, NY, (USA) VL - 19 IS - 4 SN - 0895-6111, 0895-6111 KW - Brainslem atrophy KW - Colliculi KW - Electronic measurements KW - Midbrain tegmentum KW - Pathology KW - Pons KW - Progressive supranuclear palsy KW - Visualization KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Diagnosis KW - Magnetic resonance imaging KW - Brain KW - Computerized tomography KW - W4 461.2:BIOLOGICAL MATERIALS KW - W4 461.6:MEDICINE KW - W4 461.1:BIOMEDICAL ENGINEERING KW - W4 723.5:COMPUTER APPLICATIONS KW - W 30965:Miscellaneous, Reviews KW - W4 701.2:MAGNETISM: BASIC CONCEPTS AND PHENOMENA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/15701304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computerized+Medical+Imaging+and+Graphics&rft.atitle=MR+VS+CT+in+progressive+supranuclear+palsy&rft.au=Masucci%2C+Elmo+F%3BBorts%2C+Frederick+T%3BPerl%2C+Stanley+M%3BWener%2C+Louis%3BSchwankhaus%2C+John%3BKurtzke%2C+John+F&rft.aulast=Masucci&rft.aufirst=Elmo&rft.date=1995-01-01&rft.volume=19&rft.issue=4&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Computerized+Medical+Imaging+and+Graphics&rft.issn=08956111&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Diagnosis; Magnetic resonance imaging; Brain; Computerized tomography ER - TY - JOUR T1 - Cleavage of the thyrotropin receptor does not occur at a classical subtilisin-related proprotein convertase endoproteolytic site. AN - 76903517; 7798220 AB - The human thyrotropin receptor (TSHR) undergoes proteolytic cleavage closely upstream to amino acid 317. Between residues 261 and 313 are three clusters of positively charged amino acids, arginines (Arg) and lysines (Lys), which are potential subtilisin-related proprotein convertase sites. We used oligonucleotide-directed mutagenesis to perform conservative amino acid substitutions within these regions (Arg or Lys to glutamine, Gln). Chinese hamster ovary cells stably transfected with mutant receptor cDNA TSHR-CS1 (Gln261) and TSHR-CS3 (Gln312, Gln313) bound radiolabeled TSH with an affinity similar to the wild-type TSHR. Mutant cDNA TSHR-CS2 (Gln290, Gln291) and TSHR-CS4 (Gln261, Gln290, Gln291, Gln312, Gln313) did not express a protein on the cell surface capable of specific TSH binding. After covalent cross-linkage of radiolabeled TSH to TSHR-CS1 and TSHR-CS3, the mutant receptors dissociated into two subunits under reducing conditions. The most prominent cluster of basic amino acids in the TSHR extracellular region (residues 287-293) was studied in a second series of mutations designed to eliminate the classical proprotein convertase sites in this region and yet be compatible with TSHR function. All three mutant receptors, TSHR-CS5 (Gln290), TSHR-CS6 (Gln291), and TSHR-CS7 (Gln291, Gln293) bound TSH with an affinity similar to that of wild type, and none of these amino acid substitutions prevented proteolytic cleavage of the extracellular domains of the TSHR. Thus, cleavage of the TSHR extracellular domain does not involve a classical subtilisin-related proprotein convertase cleavage site, raising the possibility that TSHR cleavage occurs after processing and trafficking of the protein to the plasma membrane. JF - The Journal of biological chemistry AU - Chazenbalk, G D AU - Rapoport, B AD - Thyroid Molecular Biology Unit, Veterans Administration Medical Center, San Francisco, California. Y1 - 1994/12/23/ PY - 1994 DA - 1994 Dec 23 SP - 32209 EP - 32213 VL - 269 IS - 51 SN - 0021-9258, 0021-9258 KW - Receptors, Thyrotropin KW - 0 KW - Serine Endopeptidases KW - EC 3.4.21.- KW - Subtilisins KW - Index Medicus KW - Animals KW - Humans KW - Molecular Sequence Data KW - CHO Cells KW - Amino Acid Sequence KW - Mutation KW - Hydrolysis KW - Cricetinae KW - Binding Sites KW - Receptors, Thyrotropin -- metabolism KW - Serine Endopeptidases -- metabolism KW - Subtilisins -- metabolism KW - Receptors, Thyrotropin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76903517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Cleavage+of+the+thyrotropin+receptor+does+not+occur+at+a+classical+subtilisin-related+proprotein+convertase+endoproteolytic+site.&rft.au=Chazenbalk%2C+G+D%3BRapoport%2C+B&rft.aulast=Chazenbalk&rft.aufirst=G&rft.date=1994-12-23&rft.volume=269&rft.issue=51&rft.spage=32209&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-01-24 N1 - Date created - 1995-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic alcohol ingestion: nerve growth factor gene expression and neurotrophic activity in rat hippocampus. AN - 77803275; 7695032 AB - Chronic ethanol treatment induces memory deficits accompanied by anatomical and biochemical changes in basal forebrain and hippocampus. Cholinergic neurons in the septohippocampal pathway are especially vulnerable to alcohol neurotoxicity. Several studies showed that an adequate supply of neurotrophins, such as Nerve Growth Factor and Brain-Derived Neurotrophic Factor, is required for the normal function and survival of cholinergic neurons in basal forebrain and medial septal nuclei. We tested the hypothesis that chronic alcohol ingestion may alter the gene expression level of Nerve Growth Factor in hippocampus, the major source of neurotrophins to the cholinergic neurons in the septohippocampal pathway. We measured Nerve Growth Factor protein and Nerve Growth Factor mRNA contents using sensitive two-site ELISA and Northern analysis. We also tested the endogenous neurotrophic activity, including and excluding Nerve Growth Factor, contained in 5%, 2%, 1%, 0.5% and 0.1% (w/v) hippocampal tissue extracts on sympathetic ganglia neurons. Twenty-eight weeks of chronic ethanol treatment did not reduce Nerve Growth Factor protein, Nerve Growth Factor mRNA, or total neurotrophic activity contained in the rat hippocampus when measured on sympathetic ganglia neurons. JF - Alcoholism, clinical and experimental research AU - Baek, J K AU - Heaton, M B AU - Walker, D W AD - Gainesville Veterans Administration Medical Center. Y1 - 1994/12// PY - 1994 DA - December 1994 SP - 1368 EP - 1376 VL - 18 IS - 6 SN - 0145-6008, 0145-6008 KW - Brain-Derived Neurotrophic Factor KW - 0 KW - Nerve Growth Factors KW - Nerve Tissue Proteins KW - RNA, Messenger KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Blotting, Northern KW - Cholinergic Fibers -- pathology KW - Ganglia, Sympathetic -- pathology KW - Biological Assay KW - RNA, Messenger -- genetics KW - Neural Pathways -- pathology KW - Septum Pellucidum -- pathology KW - Rats KW - Ganglia, Sympathetic -- drug effects KW - Enzyme-Linked Immunosorbent Assay KW - Ethanol -- toxicity KW - Cholinergic Fibers -- drug effects KW - Male KW - Nerve Growth Factors -- genetics KW - Alcoholism -- pathology KW - Hippocampus -- pathology KW - Nerve Tissue Proteins -- genetics KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77803275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Chronic+alcohol+ingestion%3A+nerve+growth+factor+gene+expression+and+neurotrophic+activity+in+rat+hippocampus.&rft.au=Baek%2C+J+K%3BHeaton%2C+M+B%3BWalker%2C+D+W&rft.aulast=Baek&rft.aufirst=J&rft.date=1994-12-01&rft.volume=18&rft.issue=6&rft.spage=1368&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-04-26 N1 - Date created - 1995-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Profound hypotension in a tetraplegic patient following angiotensin-converting enzyme inhibitor lisinopril. Case report. AN - 77798774; 7708426 AB - We present the case of a 60 year old C6 complete tetraplegic patient who developed profound hypotension following initiation of the angiotensin-converting enzyme inhibitor lisinopril to control blood pressure. Other causes of hypotension, such as myocardial infarction and sepsis was ruled out. Inhibition of the renin-angiotensin-aldosterone system was the probable cause of hypotension. This case demonstrates the critical importance of the renin-angiotensin-aldosterone axis in the maintenance of blood pressure in tetraplegic patients, who may lack input from the brain to sympathetic neurons, and therefore have increased reliance on the renin-angiotensin-aldosterone axis for the maintenance of blood pressure. Angiotensin-converting enzyme inhibitors should be avoided in tetraplegic patients, unless other treatment modalities are ineffective. JF - Paraplegia AU - Schmitt, J K AU - Koch, K S AU - Midha, M AD - Department of Internal Medicine, Hunter Holmes McGuire Veterans Administration Medical Center, Richmond, Virginia 23249. Y1 - 1994/12// PY - 1994 DA - December 1994 SP - 871 EP - 874 VL - 32 IS - 12 SN - 0031-1758, 0031-1758 KW - Angiotensin-Converting Enzyme Inhibitors KW - 0 KW - Lisinopril KW - E7199S1YWR KW - Index Medicus KW - Humans KW - Middle Aged KW - Blood Pressure -- drug effects KW - Male KW - Obesity -- complications KW - Hypotension -- chemically induced KW - Lisinopril -- adverse effects KW - Hypotension -- complications KW - Quadriplegia -- complications KW - Angiotensin-Converting Enzyme Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77798774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Paraplegia&rft.atitle=Profound+hypotension+in+a+tetraplegic+patient+following+angiotensin-converting+enzyme+inhibitor+lisinopril.+Case+report.&rft.au=Schmitt%2C+J+K%3BKoch%2C+K+S%3BMidha%2C+M&rft.aulast=Schmitt&rft.aufirst=J&rft.date=1994-12-01&rft.volume=32&rft.issue=12&rft.spage=871&rft.isbn=&rft.btitle=&rft.title=Paraplegia&rft.issn=00311758&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-05-09 N1 - Date created - 1995-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Asbestos-related disease associated with exposure to asbestiform tremolite. AN - 77790841; 7892832 AB - Tremolite is nearly ubiquitous and represents the most common amphibole fiber in the lungs of urbanites. Tremolite asbestos is not mined or used commercially but is a frequent contaminant of chrysotile asbestos, vermiculite, and talc. Therefore, individuals exposed to these materials or to end-products containing these materials may be exposed to tremolite. We have had the opportunity to do asbestos body counts and mineral fiber analysis on pulmonary tissue from five mesothelioma cases and two asbestosis cases with pulmonary tremolite burdens greater than background levels. There were no uncoated amosite or crocidolite fibers detected in any of these cases. Three patients were occupationally exposed to chrysotile asbestos; two patients had environmental exposures (one to vermiculite and one to chrysotile and talc) and one was a household contact of a shipyard worker. The tremolite burdens for the asbestosis cases were one to two orders of magnitude greater than those for the mesothelioma cases. Our study confirms the relationship between tremolite exposure and the development of asbestos-associated diseases. Furthermore, the finding of relatively modest elevations of tremolite content in some of our mesothelioma cases suggests that, at least for some susceptible individuals, moderate exposures to tremolite-contaminated dust can produce malignant pleural mesothelioma. JF - American journal of industrial medicine AU - Srebro, S H AU - Roggli, V L AD - Department of Pathology, Durham Veterans' Administration Medical Center, Durham, NC. Y1 - 1994/12// PY - 1994 DA - December 1994 SP - 809 EP - 819 VL - 26 IS - 6 SN - 0271-3586, 0271-3586 KW - Asbestos, Amphibole KW - 0 KW - Asbestos KW - 1332-21-4 KW - tremolite KW - 14567-73-8 KW - Index Medicus KW - Humans KW - Asbestosis -- pathology KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Asbestosis -- etiology KW - Lung Neoplasms -- etiology KW - Mesothelioma -- etiology KW - Occupational Exposure -- adverse effects KW - Mesothelioma -- pathology KW - Asbestos -- adverse effects KW - Environmental Exposure -- adverse effects KW - Lung Neoplasms -- pathology KW - Asbestos, Amphibole -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77790841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Asbestos-related+disease+associated+with+exposure+to+asbestiform+tremolite.&rft.au=Srebro%2C+S+H%3BRoggli%2C+V+L&rft.aulast=Srebro&rft.aufirst=S&rft.date=1994-12-01&rft.volume=26&rft.issue=6&rft.spage=809&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-04-14 N1 - Date created - 1995-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Does asbestos or asbestosis cause carcinoma of the lung? AN - 77774942; 7892835 JF - American journal of industrial medicine AU - Roggli, V L AU - Hammar, S P AU - Pratt, P C AU - Maddox, J C AU - Legier, J AU - Mark, E J AU - Brody, A R AD - Department of Pathology, Durham Veterans Administration Medical Center, Durham, NC. Y1 - 1994/12// PY - 1994 DA - December 1994 SP - 835 EP - 838 VL - 26 IS - 6 SN - 0271-3586, 0271-3586 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Animals KW - Humans KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- epidemiology KW - Asbestosis -- epidemiology KW - Asbestosis -- complications KW - Asbestos -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77774942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Does+asbestos+or+asbestosis+cause+carcinoma+of+the+lung%3F&rft.au=Roggli%2C+V+L%3BHammar%2C+S+P%3BPratt%2C+P+C%3BMaddox%2C+J+C%3BLegier%2C+J%3BMark%2C+E+J%3BBrody%2C+A+R&rft.aulast=Roggli&rft.aufirst=V&rft.date=1994-12-01&rft.volume=26&rft.issue=6&rft.spage=835&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-04-14 N1 - Date created - 1995-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vitro synergism of concentrated Allium sativum extract and amphotericin B against Cryptococcus neoformans. AN - 76920197; 7809209 AB - Allium sativum (garlic) derived preparations are used alone or with amphotericin B in Asia to treat human systemic fungal infections and cryptococcal meningitis. To evaluate the scientific merit of using allicin-derived compounds as an anti-fungal drug, we prepared a concentrated A. sativum extract that contained 34% allicin, 44% total thiosulfinates, and 20% vinyldithiins. We found that the concentrated extract possessed potent in vitro fungistatic and fungicidal activity against 3 different isolates of Cryptococcus neoformans. The minimum inhibitory concentration of the concentrated garlic extract against 1 x 10(5) organisms of C. neoformans ranged from 6 to 12 micrograms/ml. In addition, in vitro synergistic fungistatic activity with amphotericin B was demonstrated against all isolates of C. neoformans. This study lends laboratory support for the treatment of cryptococcal infections with concentrated garlic extracts. JF - Planta medica AU - Davis, L E AU - Shen, J AU - Royer, R E AD - Neurology Service (127), Veterans Administration Medical Center, Albuquerque, NM 87108. Y1 - 1994/12// PY - 1994 DA - December 1994 SP - 546 EP - 549 VL - 60 IS - 6 SN - 0032-0943, 0032-0943 KW - Antifungal Agents KW - 0 KW - Plant Extracts KW - Amphotericin B KW - 7XU7A7DROE KW - Index Medicus KW - Drug Synergism KW - Plant Extracts -- pharmacology KW - Antifungal Agents -- pharmacology KW - Plants, Medicinal KW - Cryptococcus neoformans -- drug effects KW - Amphotericin B -- pharmacology KW - Garlic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76920197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Planta+medica&rft.atitle=In+vitro+synergism+of+concentrated+Allium+sativum+extract+and+amphotericin+B+against+Cryptococcus+neoformans.&rft.au=Davis%2C+L+E%3BShen%2C+J%3BRoyer%2C+R+E&rft.aulast=Davis&rft.aufirst=L&rft.date=1994-12-01&rft.volume=60&rft.issue=6&rft.spage=546&rft.isbn=&rft.btitle=&rft.title=Planta+medica&rft.issn=00320943&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-02-01 N1 - Date created - 1995-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of Na(+)-glucose cotransport in kidney cortical cells by cadmium and copper: protection by zinc. AN - 76880327; 7992308 AB - Properties of the inhibition of Na(+)-glucose cotransport by Cd2+ in mouse kidney cortical cells have been determined. In no case was any inhibition observed before 3 hr. The extent of inhibition was dependent upon both the concentration of Cd2+ and the length of exposure. Kinetic studies showed that metallothionein mRNA induction by Cd2+ was initiated within 1 hr after incubation with Cd2+ began and peaked by 3-6 hr. Metallothionein protein increased more slowly, beginning at 3 hr and continuing for at least 9 hr. The protein had both Cd2+ and Zn2+ bound to it throughout this period. Nevertheless, a pool of nonmetallothionein Cd2+ appeared after 3 hr, coinciding with the onset of inhibition of Na(+)-glucose cotransport, and increased over the next 9 hr. Pretreatment of cells with Zn2+ protected them from the effects of Cd2+ on Na(+)-glucose cotransport. It delayed the onset of inhibition of transport as well as the extent of inhibition. Detailed analysis of the distribution of Cd2+ and Zn2+ in the soluble fraction of these cells showed that the concentration of non-metallothionein bound Cd2+ was not suppressed by the presence of Zn-metallothionein after the onset of exposure to Cd2+. Incubation of cells with larger concentration of Zn2+ and Cu2+ also inhibited Na(+)-glucose cotransport. JF - Toxicology and applied pharmacology AU - Blumenthal, S AU - Lewand, D AU - Sochanik, A AU - Krezoski, S AU - Petering, D H AD - Department of Nephrology, Veterans Administration Medical Center, Milwaukee, Wisconsin 53295. Y1 - 1994/12// PY - 1994 DA - December 1994 SP - 177 EP - 187 VL - 129 IS - 2 SN - 0041-008X, 0041-008X KW - RNA, Messenger KW - 0 KW - Cadmium KW - 00BH33GNGH KW - Copper KW - 789U1901C5 KW - Metallothionein KW - 9038-94-2 KW - Sodium KW - 9NEZ333N27 KW - Glucose KW - IY9XDZ35W2 KW - Zinc KW - J41CSQ7QDS KW - Index Medicus KW - Biological Transport, Active -- drug effects KW - Animals KW - Metallothionein -- biosynthesis KW - Kidney Tubules, Proximal -- metabolism KW - Cells, Cultured KW - Kinetics KW - Mice, Inbred C57BL KW - Mice KW - RNA, Messenger -- biosynthesis KW - Male KW - Kidney Tubules, Proximal -- cytology KW - Zinc -- pharmacology KW - Kidney Cortex -- cytology KW - Glucose -- metabolism KW - Copper -- antagonists & inhibitors KW - Cadmium -- toxicity KW - Kidney Cortex -- metabolism KW - Copper -- toxicity KW - Cadmium -- antagonists & inhibitors KW - Sodium -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76880327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Inhibition+of+Na%28%2B%29-glucose+cotransport+in+kidney+cortical+cells+by+cadmium+and+copper%3A+protection+by+zinc.&rft.au=Blumenthal%2C+S%3BLewand%2C+D%3BSochanik%2C+A%3BKrezoski%2C+S%3BPetering%2C+D+H&rft.aulast=Blumenthal&rft.aufirst=S&rft.date=1994-12-01&rft.volume=129&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-01-06 N1 - Date created - 1995-01-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol Dependence and Anxiety Disorders: What Is the Relationship? AN - 1761712780; 199503813 AB - The relationship between alcohol dependence & major anxiety disorders was examined through critical review of journal articles published since 1975. The review revealed only slightly higher rates of panic disorder, general anxiety disorder, & social phobia among alcoholics than in the general population. Little support was found for higher risk of major diagnosable anxiety disorders among offspring of alcoholic parents. Some evidence existed for improvement of anxiety symptoms among the alcohol dependent with abstinence. Marked alcoholism was not found among patients with anxiety disorders, & family cross-over between alcoholism & anxiety disorder was not evident. Evidence of temporary, but at times severe, substance-induced anxiety syndromes was found. 5 Tables, 111 References. Adapted from the source document. JF - The American Journal of Psychiatry AU - Schuckit, Marc A AU - Hesselbrock, Victor AD - Veterans Administration Medical Center, 3350 La Jolla Village Dr San Diego CA 92161-9116 Y1 - 1994/12// PY - 1994 DA - December 1994 SP - 1723 EP - 1734 VL - 151 IS - 12 SN - 0002-953X, 0002-953X KW - alcohol dependence-anxiety disorders relationship KW - 1975-present journal articles KW - Alcohol Abuse KW - Anxiety KW - Alcoholism KW - article KW - 6142: mental & emotional problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761712780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Alcohol+Dependence+and+Anxiety+Disorders%3A+What+Is+the+Relationship%3F&rft.au=Schuckit%2C+Marc+A%3BHesselbrock%2C+Victor&rft.aulast=Schuckit&rft.aufirst=Marc&rft.date=1994-12-01&rft.volume=151&rft.issue=12&rft.spage=1723&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Alcohol Abuse; Anxiety; Alcoholism ER - TY - JOUR T1 - Word recognition in the human inferior temporal lobe. AN - 85164764; pmid-7969469 AB - Studies of primates and of patients with brain lesions have shown that the visual system represents the external world in regions and pathways specialized to compute visual features and attributes. For example, object recognition is performed by a ventral pathway located in the inferior portion of the temporal lobe. We studied visual processing of words and word-like stimuli (letter-strings) by recording field potentials directly from the human inferior temporal lobe. Our results showed that two discrete portions of the fusiform gyrus responded preferentially to letter-strings. A region of the posterior fusiform gyrus responded equally to words and non-words, and was unaffected by the semantic context in which words were presented. In contrast, a region of the anterior fusiform gyrus was sensitive to these stimulus dimensions. These regions were distinct from areas that responded to other types of complex visual stimuli, including faces and coloured patterns, and thus form a functionally specialized stream within the ventral visual pathway. JF - Nature AU - Nobre, A C AU - Allison, T AU - McCarthy, G AD - Neuropsychology Laboratory, Veterans Administration Medical Center, West Haven, Connecticut 06516. PY - 1994 SP - 260 EP - 263 VL - 372 IS - 6503 SN - 0028-0836, 0028-0836 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85164764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Word+recognition+in+the+human+inferior+temporal+lobe.&rft.au=Nobre%2C+A+C%3BAllison%2C+T%3BMcCarthy%2C+G&rft.aulast=Nobre&rft.aufirst=A&rft.date=1994-11-01&rft.volume=372&rft.issue=6503&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Longitudinal changes in lung function among asbestos-exposed workers. AN - 76791087; 7952547 AB - To prospectively identify the determinants of persistent or accelerated loss of lung function among workers occupationally exposed to asbestos and assess the relative contribution of cigarette smoking, asbestos-induced pleural fibrosis, and specific findings from bronchoalveolar lavage and high resolution CT scans, we examined the determinants of lung function changes in 117 subjects occupationally exposed to asbestos for at least 1 yr in a high exposure setting. A minimum of 20 yr was required between the first exposure to asbestos and entry into the study. Baseline studies included an independent assessment of dyspnea, lung volumes, diffusing capacity of carbon monoxide (DLCO), a chest radiograph, a high resolution CT (HRCT) scan, and bronchoalveolar lavage (BAL). Subjects were observed for an average of 2 yr (range, 0.5 to 4.0 yr), and lung function was measured on at least two separate occasions (mean, 4.1 separate tests). During the period of observation, there was an average 1.5% decrease in the TLC and a 2.5% decrease in the DLCO. In this longitudinal data set, after controlling for age, height, pack-years of cigarette smoking, and follow-up time, persistently lower measures of TLC were independently related to moderate to severe dyspnea (p = 0.005), diffuse pleural thickening (p = 0.007), and higher concentrations of fibronectin in BAL fluid (p = 0.01). Interstitial lung disease either on the chest radiograph or HRCT scan was not independently associated with persistently lower measures of TLC during the period of observation. However, none of the clinical variables we examined were associated with an accelerated decline in TLC.(ABSTRACT TRUNCATED AT 250 WORDS) JF - American journal of respiratory and critical care medicine AU - Schwartz, D A AU - Davis, C S AU - Merchant, J A AU - Bunn, W B AU - Galvin, J R AU - Van Fossen, D S AU - Dayton, C S AU - Hunninghake, G W AD - Department of Internal Medicine, Department of Veterans Administration Medical Center, Iowa City, Iowa. Y1 - 1994/11// PY - 1994 DA - November 1994 SP - 1243 EP - 1249 VL - 150 IS - 5 Pt 1 SN - 1073-449X, 1073-449X KW - Asbestos KW - 1332-21-4 KW - Abridged Index Medicus KW - Index Medicus KW - Lung -- diagnostic imaging KW - Vital Capacity KW - Humans KW - Pulmonary Diffusing Capacity KW - Tomography, X-Ray Computed KW - Total Lung Capacity KW - Forced Expiratory Volume KW - Longitudinal Studies KW - Asbestosis -- diagnosis KW - Smoking KW - Prospective Studies KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Middle Aged KW - Dyspnea -- etiology KW - Bronchoalveolar Lavage Fluid -- cytology KW - Male KW - Occupational Exposure KW - Respiratory Mechanics KW - Asbestos -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76791087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Longitudinal+changes+in+lung+function+among+asbestos-exposed+workers.&rft.au=Schwartz%2C+D+A%3BDavis%2C+C+S%3BMerchant%2C+J+A%3BBunn%2C+W+B%3BGalvin%2C+J+R%3BVan+Fossen%2C+D+S%3BDayton%2C+C+S%3BHunninghake%2C+G+W&rft.aulast=Schwartz&rft.aufirst=D&rft.date=1994-11-01&rft.volume=150&rft.issue=5+Pt+1&rft.spage=1243&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-12-13 N1 - Date created - 1994-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reliability and Validity of the Addiction Severity Index with a Homeless Sample AN - 1761716992; 199504645 AB - Examines the reliability & validity of the Addiction Severity Index (ASI) in a sample of 98 homeless substance users awaiting temporary housing placement. Test-retest reliability found the ASI to have moderate to high reliability coefficients in each of the 7 domains assessed. Both composite score & severity rating measures were found to be quite independent with low intercorrelations. Three of the 7 ASI composite scores -- alcohol, drug, & psychiatric -- were found to have moderate concurrent validity. Composite score interitem correlations were .70 or greater in each of the domains except for employment & family. These data suggest that the ASI has acceptable reliability & validity. 3 Tables, 23 References. Adapted from the source document. JF - Journal of Substance Abuse Treatment AU - Zanis, David A AU - McLellan, A Thomas AU - Cnaan, Ram A AU - Randall, Mary AD - Philadelphia Veterans Administration Medical Center, Bldg 7 University & Woodland Aves PA 19104 Y1 - 1994/11// PY - 1994 DA - November 1994 SP - 541 EP - 548 VL - 11 IS - 6 SN - 0740-5472, 0740-5472 KW - homeless substance users, Addiction Severity Index, reliability/validity tested KW - Substance Abuse KW - Reliability KW - Validity KW - Methodology (Data Analysis) KW - Homelessness KW - article KW - 6129: addiction KW - 6141: poverty & homelessness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761716992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Reliability+and+Validity+of+the+Addiction+Severity+Index+with+a+Homeless+Sample&rft.au=Zanis%2C+David+A%3BMcLellan%2C+A+Thomas%3BCnaan%2C+Ram+A%3BRandall%2C+Mary&rft.aulast=Zanis&rft.aufirst=David&rft.date=1994-11-01&rft.volume=11&rft.issue=6&rft.spage=541&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Reliability; Validity; Methodology (Data Analysis); Homelessness; Substance Abuse ER - TY - JOUR T1 - Activation of phospholipase D in human platelets by collagen and thrombin and its relationship to platelet aggregation. AN - 76792674; 7948037 AB - Stimulation of phospholipase D after activation of cell surface receptors has been reported in many cell types. We have investigated the mechanism of activation of this enzyme by collagen in the human platelet by assaying the release of [3H]methylcholine from [3H]methylphosphatidylcholine. Results from these studies suggest that phospholipase D activity is regulated by reversible phosphorylation. Phospholipase D activity was stimulated when platelet-rich plasma was preincubated with collagen and was not inhibited by aspirin. Among various aggregating agents tested, collagen and thrombin but not ADP activated phospholipase D activity (2- to 3-fold). The addition of sphingosine inhibited phospholipase D activity. Preincubation of platelet-rich plasma with sphingosine inhibited collagen- and thrombin-induced platelet aggregation and the release of ATP. The inhibitory effect of sphingosine on collagen- and thrombin- induced platelet aggregation and release of ATP was dose-dependent. The functional significance of phospholipase D activation was also tested by examining the effect of the product, phosphatidic acid, on collagen-induced platelet aggregation and release of ATP. Platelet shape change and the reversibility of platelet aggregation resulted by the addition of phosphatidic acid to platelet-rich plasma. Furthermore, the simultaneous addition of phosphatidic acid and collagen shortened the latency period but had no effect on platelet aggregation. Two platelet proteins (47 kDa and 22 kDa) increased in phosphorylation after the addition of 1 microM phosphatidic acid which did not cause platelet aggregation. These results suggest that collagen stimulates phospholipase D activity which plays a secondary role in platelet aggregation and the release reaction. JF - Biochimica et biophysica acta AU - Chiang, T M AD - Veterans Administration Medical Center, Memphis, TN 38104. Y1 - 1994/10/20/ PY - 1994 DA - 1994 Oct 20 SP - 147 EP - 155 VL - 1224 IS - 1 SN - 0006-3002, 0006-3002 KW - Arsenicals KW - 0 KW - Ethers, Cyclic KW - Platelet Aggregation Inhibitors KW - oxophenylarsine KW - 0HUR2WY345 KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Collagen KW - 9007-34-5 KW - Phospholipase D KW - EC 3.1.4.4 KW - Thrombin KW - EC 3.4.21.5 KW - Sphingosine KW - NGZ37HRE42 KW - Index Medicus KW - Humans KW - Enzyme Activation -- drug effects KW - Adenosine Triphosphate -- analysis KW - Arsenicals -- pharmacology KW - Sphingosine -- pharmacology KW - Platelet Aggregation Inhibitors -- pharmacology KW - Ethers, Cyclic -- pharmacology KW - Phospholipase D -- metabolism KW - Thrombin -- pharmacology KW - Blood Platelets -- drug effects KW - Blood Platelets -- enzymology KW - Thrombin -- antagonists & inhibitors KW - Collagen -- pharmacology KW - Platelet Aggregation -- drug effects KW - Collagen -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76792674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Activation+of+phospholipase+D+in+human+platelets+by+collagen+and+thrombin+and+its+relationship+to+platelet+aggregation.&rft.au=Chiang%2C+T+M&rft.aulast=Chiang&rft.aufirst=T&rft.date=1994-10-20&rft.volume=1224&rft.issue=1&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-12-07 N1 - Date created - 1994-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Syntactic Constructions Used by Agrammatic Speakers: Comparison with Conduction Aphasics and Normals AN - 85555615; 9501838 AB - This study addressed the syntactic structural features that distinguish the utterances of agrammatic speakers in free narrative from those of conduction aphasics & normals. Agrammatics' utterances were marked by a high proportion of single-constituent utterances & a preponderance of nouns over verbs in single-constituent utterances as well as in sentences, in comparison with both other groups. The number of sentential constituents per utterance was no less for agrammatics than for the other speakers, when the number of words per utterance was controlled. However, the constituents forming most of the utterances of agrammatics were those minimally required for a canonical syntactic sequence. Conduction aphasics had a significantly greater proportion of optional elaborations, in the form of adverbs & prepositional phrases, than did the agrammatics, & normal subjects had a significantly greater proportion than the conduction aphasics. 6 Tables, 4 Figures, 37 References. [Reprinted with permission from the American Psychological Association] JF - Neuropsychology AU - Goodglass, Harold AU - Christiansen, Julie Ann AU - Gallagher, Roberta E AD - Psychology Service Veterans Administration Medical Center, 150 South Huntington Ave Boston MA 02130 Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 598 EP - 613 VL - 8 IS - 4 SN - 0894-4105, 0894-4105 KW - agrammatic speech, syntactic structural features KW - free narrative analysis KW - agrammatic/conduction aphasic/normal subjects KW - Agrammatism (01200) KW - Aphasia (03400) KW - Language Pathology (43250) KW - Grammatical Analysis (28700) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85555615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychology&rft.atitle=Syntactic+Constructions+Used+by+Agrammatic+Speakers%3A+Comparison+with+Conduction+Aphasics+and+Normals&rft.au=Goodglass%2C+Harold%3BChristiansen%2C+Julie+Ann%3BGallagher%2C+Roberta+E&rft.aulast=Goodglass&rft.aufirst=Harold&rft.date=1994-10-01&rft.volume=8&rft.issue=4&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=Neuropsychology&rft.issn=08944105&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - NEUPEG N1 - SubjectsTermNotLitGenreText - Agrammatism (01200); Aphasia (03400); Language Pathology (43250); Grammatical Analysis (28700) ER - TY - JOUR T1 - Concurrent validity of the cognitive component of schizophrenia: relationship of PANSS scores to neuropsychological assessments. AN - 85266941; pmid-7701028 AB - Cognitive symptoms of schizophrenia may represent a separate component of the disorder that is distinct from positive or negative syndromes. In a previous study, we reported a factor analysis of the Positive and Negative Syndrome Scale (PANSS) that revealed five components, one of which we labeled the Cognitive component. In the present study, we explored the validity of the PANSS Cognitive component by examining correlations between neuropsychological measures and the five factor-analytically derived PANSS scores for 147 subjects with diagnoses of schizophrenia or schizoaffective disorder. Higher scores on the PANSS Cognitive component were significantly correlated with poorer performance on all neuropsychological tests, including the Wisconsin Card Sorting Test (WCST), the Digit Symbol Substitution Task, the Slosson Intelligence Test, and the Gorham Proverbs Test. Multiple regression revealed that these test scores explained 37% of the variance in the Cognitive component score. Neuropsychological tests have very limited associations with the other PANSS components. These results suggest that the Cognitive component of the PANSS is a valid measure of cognitive deficits in schizophrenia, and they support the hypothesis that Cognitive impairment is a distinctive feature of schizophrenia independent of positive and negative syndromes. JF - Psychiatry Research AU - Bell, M D AU - Lysaker, P H AU - Milstein, R M AU - Beam-Goulet, J L AD - Psychology Service, Veterans Administration Medical Center, West Haven, CT 06516, USA. PY - 1994 SP - 51 EP - 58 VL - 54 IS - 1 SN - 0165-1781, 0165-1781 KW - Schizophrenia KW - Emotions KW - Diagnosis, Differential KW - Reproducibility of Results KW - Human KW - Adult KW - Neuropsychological Tests KW - Psychometrics KW - Cognition KW - Female KW - Male KW - Schizophrenic Psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85266941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+Research&rft.atitle=Concurrent+validity+of+the+cognitive+component+of+schizophrenia%3A+relationship+of+PANSS+scores+to+neuropsychological+assessments.&rft.au=Bell%2C+M+D%3BLysaker%2C+P+H%3BMilstein%2C+R+M%3BBeam-Goulet%2C+J+L&rft.aulast=Bell&rft.aufirst=M&rft.date=1994-10-01&rft.volume=54&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Psychiatry+Research&rft.issn=01651781&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Prediction of occult neck disease in laryngeal cancer by means of a logistic regression statistical model. AN - 85189734; pmid-7934602 AB - The ability to accurately predict the presence of subclinical metastatic neck disease in clinically N0 patients with primary epidermoid cancer of the larynx would be of great value in determining whether to perform an elective neck dissection. We describe a statistical approach to estimating the probability of occult neck disease given pretreatment clinical parameters. A retrospective study was performed involving 736 clinically N0 patients with primary laryngeal cancer who were treated surgically with primary resection and ipsilateral neck dissection. Nodal involvement was determined histologically after surgical lymphadenectomy. A logistic regression model was used to derive an equation that calculated the probability of occult neck metastasis based on pretreatment T stage, tumor location, and histologic grade. The model has a sensitivity of 74%, a specificity of 87%, and can be entered into a programmable calculator. JF - The Laryngoscope AU - Ghouri, A F AU - Zamora, R L AU - Sessions, D G AU - Spitznagel, E L AU - Harvey, J E AD - Department of Surgery, Veterans Administration Medical Center, Des Moines. PY - 1994 SP - 1280 EP - 1284 VL - 104 IS - 10 SN - 0023-852X, 0023-852X KW - Probability KW - Lymphatic Metastasis KW - Human KW - Retrospective Studies KW - Aged KW - Laryngeal Neoplasms KW - Prospective Studies KW - Comparative Study KW - Aged, 80 and over KW - Head and Neck Neoplasms KW - Adult KW - Middle Age KW - Lymph Node Excision KW - Carcinoma, Squamous Cell KW - Male KW - Female KW - Neck Dissection KW - Logistic Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85189734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Prediction+of+occult+neck+disease+in+laryngeal+cancer+by+means+of+a+logistic+regression+statistical+model.&rft.au=Ghouri%2C+A+F%3BZamora%2C+R+L%3BSessions%2C+D+G%3BSpitznagel%2C+E+L%3BHarvey%2C+J+E&rft.aulast=Ghouri&rft.aufirst=A&rft.date=1994-10-01&rft.volume=104&rft.issue=10&rft.spage=1280&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Agranulocytosis in a hyperthyroid patient. AN - 76875443; 7990454 JF - Journal of the Tennessee Medical Association AU - Tisdale, J F AU - Kemp, W E AD - Veterans Administration Medical Center, Nashville. Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 433 EP - 434 VL - 87 IS - 10 SN - 0040-3318, 0040-3318 KW - Propylthiouracil KW - 721M9407IY KW - Index Medicus KW - Leukocyte Count -- drug effects KW - Bone Marrow -- pathology KW - Humans KW - Heart Failure -- chemically induced KW - Aged KW - Bone Marrow -- drug effects KW - Male KW - Propylthiouracil -- administration & dosage KW - Hyperthyroidism -- drug therapy KW - Propylthiouracil -- adverse effects KW - Agranulocytosis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76875443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Tennessee+Medical+Association&rft.atitle=Agranulocytosis+in+a+hyperthyroid+patient.&rft.au=Tisdale%2C+J+F%3BKemp%2C+W+E&rft.aulast=Tisdale&rft.aufirst=J&rft.date=1994-10-01&rft.volume=87&rft.issue=10&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Tennessee+Medical+Association&rft.issn=00403318&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-01-09 N1 - Date created - 1995-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization. AN - 76751034; 7523419 AB - There is ample in vitro evidence that phosphorylation of intermediate filaments, including keratins, plays an important role in filament reorganization. In order to gain a better understanding of the function of intermediate filament phosphorylation, we sought to identify the major phosphorylation site of human keratin polypeptide 18 (K18) and study its role in filament assembly or reorganization. We generated a series of K18 ser-->ala mutations at potential phosphorylation sites, followed by expression in insect cells and comparison of the tryptic 32PO4-labeled patterns of the generated constructs. Using this approach, coupled with Edman degradation of the 32PO4-labeled tryptic peptides, and comparison with tryptic peptides analyzed after labeling normal human colonic tissues, we identified ser-52 as the major K18 physiologic phosphorylation site. Ser-52 in K18 is not glycosylated and matches consensus sequences for phosphorylation by CAM kinase, S6 kinase and protein kinase C, and all these kinases can phosphorylate K18 in vitro predominantly at that site. Expression of K18 ser-52-->ala mutant in mammalian cells showed minimal phosphorylation but no distinguishable difference in filament assembly when compared with wild-type K18. In contrast, the ser-52 mutation played a clear but nonexclusive role in filament reorganization, based on analysis of filament alterations in cells treated with okadaic acid or arrested at the G2/M stage of the cell cycle. Our results show that ser-52 is the major physiologic phosphorylation site of human K18 in interphase cells, and that its phosphorylation may play an in vivo role in filament reorganization. JF - The Journal of cell biology AU - Ku, N O AU - Omary, M B AD - Palo Alto Veterans Administration Medical Center, CA 94304. Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 161 EP - 171 VL - 127 IS - 1 SN - 0021-9525, 0021-9525 KW - Ethers, Cyclic KW - 0 KW - Phosphopeptides KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Serine KW - 452VLY9402 KW - Keratins KW - 68238-35-7 KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - Index Medicus KW - Phosphoprotein Phosphatases -- antagonists & inhibitors KW - Animals KW - Spodoptera KW - Peptide Mapping KW - Phosphopeptides -- analysis KW - Humans KW - Amino Acid Sequence KW - Mice KW - Ethers, Cyclic -- pharmacology KW - Serine -- metabolism KW - Baculoviridae -- genetics KW - Phosphorylation KW - Mutation -- physiology KW - Molecular Sequence Data KW - Cell Line KW - Keratins -- metabolism KW - Keratins -- genetics KW - Intermediate Filaments -- metabolism KW - Protein-Serine-Threonine Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76751034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+cell+biology&rft.atitle=Identification+of+the+major+physiologic+phosphorylation+site+of+human+keratin+18%3A+potential+kinases+and+a+role+in+filament+reorganization.&rft.au=Ku%2C+N+O%3BOmary%2C+M+B&rft.aulast=Ku&rft.aufirst=N&rft.date=1994-10-01&rft.volume=127&rft.issue=1&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+cell+biology&rft.issn=00219525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-10-31 N1 - Date created - 1994-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Cell Biol. 1992 Feb;4(1):99-104 [1558758] Methods Enzymol. 1991;200:252-68 [1956321] Nature. 1992 Jun 4;357(6377):413-5 [1375708] Anal Biochem. 1992 Jan;200(1):81-8 [1595905] Cell. 1992 Jun 12;69(6):899-902 [1376637] Biochem Biophys Res Commun. 1992 Jul 15;186(1):524-30 [1321614] J Biol Chem. 1992 Aug 25;267(24):17216-24 [1324926] Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8736-40 [1382297] Trends Neurosci. 1991 Nov;14(11):501-6 [1726767] J Cell Biochem. 1992 Aug;49(4):378-93 [1331124] Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):11093-7 [1332069] Cancer Res. 1993 Mar 1;53(5):992-6 [7679949] J Biol Chem. 1993 Feb 25;268(6):4465-72 [7680039] Curr Opin Cell Biol. 1993 Feb;5(1):17-29 [7680567] Curr Opin Cell Biol. 1993 Feb;5(1):3-11 [8448027] Cell. 1993 Apr 9;73(1):23-33 [8462100] Cell. 1993 Apr 9;73(1):35-46 [8462101] J Cell Biol. 1993 Apr;121(2):387-95 [8468353] J Biol Chem. 1993 May 15;268(14):10416-24 [8486697] Genes Dev. 1993 Jul;7(7A):1191-202 [7686525] J Cell Sci. 1993 Jun;105 ( Pt 2):433-44 [7691841] Biochem Biophys Res Commun. 1993 Oct 15;196(1):115-23 [8216281] Neuron. 1994 Feb;12(2):389-405 [8110465] Exp Cell Res. 1994 Mar;211(1):24-35 [7510249] Nat Genet. 1994 Jan;6(1):6-7 [7511022] Curr Opin Cell Biol. 1994 Feb;6(1):25-33 [8167022] Nature. 1970 Aug 15;227(5259):680-5 [5432063] J Biol Chem. 1983 Mar 25;258(6):4019-25 [6339492] J Cell Biol. 1983 Nov;97(5 Pt 1):1429-34 [6195164] Nucleic Acids Res. 1983 Nov 11;11(21):7631-48 [6316266] J Cell Biol. 1984 Mar;98(3):1001-9 [6199361] Differentiation. 1986;33(1):61-8 [2434380] Methods Enzymol. 1986;134:355-71 [2434826] Nature. 1987 Aug 13-19;328(6131):649-52 [3039376] J Biol Chem. 1988 Apr 25;263(12):5970-8 [2833525] Eur J Cell Biol. 1988 Apr;46(1):152-60 [3294004] Annu Rev Biochem. 1988;57:593-625 [3052284] Biochem J. 1988 Nov 15;256(1):283-90 [2851982] Proc Natl Acad Sci U S A. 1989 Mar;86(6):1885-9 [2648386] J Cell Biol. 1989 Jun;108(6):2409-22 [2661562] Nucleic Acids Res. 1989 Sep 12;17(17):7110 [2780323] J Cell Biol. 1989 Oct;109(4 Pt 1):1665-76 [2477379] Cell Motil Cytoskeleton. 1989;14(3):309-31 [2684432] Methods Enzymol. 1991;200:62-81 [1956339] J Cell Biol. 1991 Dec;115(6):1661-74 [1721910] J Biol Chem. 1992 Feb 25;267(6):3901-6 [1371281] J Biol Chem. 1989 Dec 5;264(34):20620-4 [2511207] Biochem Biophys Res Commun. 1990 Mar 30;167(3):1316-25 [2108674] Mol Endocrinol. 1990 Mar;4(3):370-4 [1692965] Cell. 1990 May 18;61(4):579-89 [2344612] Proc Natl Acad Sci U S A. 1991 May 1;88(9):3812-6 [2023931] EMBO J. 1991 Jun;10(6):1535-44 [1851086] Eur J Biochem. 1991 Apr 23;197(2):281-90 [1709097] FEBS Lett. 1991 Apr 22;282(1):200-4 [1709119] J Cell Biol. 1991 Aug;114(4):787-97 [1714462] J Biol Chem. 1991 Aug 25;266(24):15555-8 [1651913] Cell Motil Cytoskeleton. 1991;19(2):67-79 [1878980] Methods Enzymol. 1991;201:110-49 [1943760] J Cell Biol. 1992 May;117(3):583-93 [1374067] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of antisecretory agents on parietal cell structure and H/K-ATPase levels in rabbit gastric mucosa in vivo. AN - 76742357; 7924730 AB - The effect of inhibition of acid secretion on parietal cell morphology and the concentration of H,K-ATPase alpha-subunit protein was determined by electron microscopy and western blotting. Omeprazole or famotidine alone or in combination were used. Control animals showed a morphological stimulation index (0 = resting, 1.0 = fully stimulated) of 0.60; omeprazole treatment (1 mg/kg, twice a day) resulted a stimulation index of 0.63, famotidine injection (20 mg/kg twice a day) an index of 0.11, famotidine infusion (0.2 mg/hr) for five days an index of 0.38, and the combination of omeprazole and famotidine injection twice a day gave an index of 0.02. No change in the frequency of degenerating or damaged parietal cells was observed in any of the groups. In control animals, the number of lysosomes was 0.9/cell, with famotidine 1.8 and with omeprazole 5.6/cell. H/K-ATPase levels fell by about 25% with omeprazole and rose by about 23% with famotidine. JF - Digestive diseases and sciences AU - Scott, D R AU - Besancon, M AU - Sachs, G AU - Helander, H AD - Laboratory of Membrane Biology, Veterans Administration Medical Center West Los Angeles, Wadsworth Division, California 90073. Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 2118 EP - 2126 VL - 39 IS - 10 SN - 0163-2116, 0163-2116 KW - Famotidine KW - 5QZO15J2Z8 KW - Cimetidine KW - 80061L1WGD KW - H(+)-K(+)-Exchanging ATPase KW - EC 3.6.3.10 KW - Omeprazole KW - KG60484QX9 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Drug Interactions KW - Blotting, Western KW - Rabbits KW - Microscopy, Electron KW - Cimetidine -- pharmacology KW - Male KW - Omeprazole -- pharmacology KW - Gastric Mucosa -- ultrastructure KW - Omeprazole -- administration & dosage KW - Gastric Acid -- secretion KW - Gastric Mucosa -- enzymology KW - Gastric Mucosa -- chemistry KW - Famotidine -- administration & dosage KW - Parietal Cells, Gastric -- drug effects KW - Parietal Cells, Gastric -- ultrastructure KW - Famotidine -- pharmacology KW - H(+)-K(+)-Exchanging ATPase -- drug effects KW - H(+)-K(+)-Exchanging ATPase -- metabolism KW - Gastric Mucosa -- drug effects KW - H(+)-K(+)-Exchanging ATPase -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76742357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+and+sciences&rft.atitle=Effects+of+antisecretory+agents+on+parietal+cell+structure+and+H%2FK-ATPase+levels+in+rabbit+gastric+mucosa+in+vivo.&rft.au=Scott%2C+D+R%3BBesancon%2C+M%3BSachs%2C+G%3BHelander%2C+H&rft.aulast=Scott&rft.aufirst=D&rft.date=1994-10-01&rft.volume=39&rft.issue=10&rft.spage=2118&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+and+sciences&rft.issn=01632116&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-11-10 N1 - Date created - 1994-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethnicity in the Elderly AN - 61410486; 9506972 AB - A review essay on seven books (see listings in IRPS No. 79) discussing issues of ethnicity among the elderly. The books are critiqued from the perspective of critical gerontology. Although the works reveal interesting cross-ethnic differences in health status, functioning, & life time opportunities, all adhere to a concept of ethnicity that treats each ethnic group as an entity unto itself. This concept is inadequate because: (1) it confuses ethnic with minority or socioeconomic class status; (2) it disregards heterogeneity within ethnic groups; & (3) it dismisses the importance of social discrimination in explaining some outcomes. Moreover, by eluding the dynamic qualities of culture & ethnicity, these contributions sidestep the advancement of theory & methodology in social gerontology. 24 References. R. Jaramillo JF - Journal of Cross-Cultural Gerontology AU - Kramer, B Josea AU - Barker, Judith C AD - Geriatric Research Evaluation & Clinical Center Veterans Administration Medical Center, 16111 Plummer St Sepulveda CA 93143 Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 403 EP - 417 VL - 9 IS - 4 SN - 0169-3816, 0169-3816 KW - elderly, ethnicity issues KW - 7-book review essay KW - Ethnic Groups KW - Ethnicity KW - Gerontology KW - Elderly KW - Health KW - article KW - 2143: social problems and social welfare; social gerontology KW - 0410: group interactions; social group identity & intergroup relations (groups based on race & ethnicity, age, & sexual orientation) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61410486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cross-Cultural+Gerontology&rft.atitle=Ethnicity+in+the+Elderly&rft.au=Kramer%2C+B+Josea%3BBarker%2C+Judith+C&rft.aulast=Kramer&rft.aufirst=B&rft.date=1994-10-01&rft.volume=9&rft.issue=4&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cross-Cultural+Gerontology&rft.issn=01693816&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JCCGEB N1 - SubjectsTermNotLitGenreText - Ethnicity; Elderly; Health; Ethnic Groups; Gerontology ER - TY - JOUR T1 - "I Prayed Real Hard, So I Know I'll Get In": Living with Randomization AN - 61392754; 9509832 AB - Practical difficulties encountered when using an experimental design involving human Ss with multiple serious needs are examined through case study of the implementation of a randomized clinical trial for homeless substance abusers at the New Haven Project in CT. Prior to implementation, the research staff & community services providers had the concern that randomization would produce a negative effect on usual care group Ss & a halo effect on experimental Ss. Ethnographic analysis of interviews with program participants (N = 182) determined that the randomization process did not have any uniform effect on program participants. It did, however, anger other community agencies, & produced a substantial slowing of referrals. Randomization also placed a strain on program staff & research staff & created tension between them. Changes in the randomization process were necessary to accommodate program participation, but these changes did not undermine the equivalence of the experimental & control groups. 4 References. Adapted from the source document. JF - New Directions for Program Evaluation AU - Lam, Julie A AU - Hartwell, Stephanie Wilson AU - Jekel, James F AD - Northeast Program Evaluation Center Veterans Administration Medical Center, 950 Campbell Ave West Haven CT 06516-2700 Y1 - 1994/10// PY - 1994 DA - October 1994 SP - 55 EP - 66 IS - 63 KW - randomized clinical trial, homeless substance abusers, New Haven, Connecticut KW - case study KW - Experiments KW - Substance Abuse KW - Program Implementation KW - Random Samples KW - Connecticut KW - Homelessness KW - article KW - 0104: methodology and research technology; research methods/tools UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61392754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+Directions+for+Program+Evaluation&rft.atitle=%22I+Prayed+Real+Hard%2C+So+I+Know+I%27ll+Get+In%22%3A+Living+with+Randomization&rft.au=Lam%2C+Julie+A%3BHartwell%2C+Stephanie+Wilson%3BJekel%2C+James+F&rft.aulast=Lam&rft.aufirst=Julie&rft.date=1994-10-01&rft.volume=&rft.issue=63&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=New+Directions+for+Program+Evaluation&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - NDPEEJ N1 - SubjectsTermNotLitGenreText - Random Samples; Experiments; Program Implementation; Homelessness; Substance Abuse; Connecticut ER - TY - JOUR T1 - Factors associated with employment among methadone patients. AN - 77751384; 7869465 AB - We examined the patient characteristics of 340 subjects in methadone treatment to determine if these characteristics could differentiate among three "stages" of work during the past year (stable unemployment, intermittent work, and stable employment). A multiple discriminant function analysis was able to classify correctly 14% of the cases beyond chance. Results of these analyses found lower depression scores, cocaine abstinence, education, and marital status correlated with stable employment conditions. Interventions designed to change these characteristics may improve employment conditions among methadone patients. JF - Journal of substance abuse treatment AU - Zanis, D A AU - Metzger, D S AU - McLellan, A T AD - Penn-VA Center for Studies of Addiction, Philadelphia Veterans Administration Medical Center 19104. PY - 1994 SP - 443 EP - 447 VL - 11 IS - 5 SN - 0740-5472, 0740-5472 KW - Cocaine KW - I5Y540LHVR KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - AIDS/HIV KW - Depressive Disorder -- psychology KW - Humans KW - Unemployment -- statistics & numerical data KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Longitudinal Studies KW - Comorbidity KW - Depressive Disorder -- epidemiology KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - HIV Seropositivity -- epidemiology KW - Philadelphia -- epidemiology KW - Female KW - Male KW - Substance-Related Disorders -- epidemiology KW - Depressive Disorder -- rehabilitation KW - Opioid-Related Disorders -- epidemiology KW - Methadone -- therapeutic use KW - Urban Population -- statistics & numerical data KW - Opioid-Related Disorders -- psychology KW - Rehabilitation, Vocational -- statistics & numerical data KW - Rehabilitation, Vocational -- psychology KW - Opioid-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77751384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Factors+associated+with+employment+among+methadone+patients.&rft.au=Zanis%2C+D+A%3BMetzger%2C+D+S%3BMcLellan%2C+A+T&rft.aulast=Zanis&rft.aufirst=D&rft.date=1994-09-01&rft.volume=11&rft.issue=5&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-03-28 N1 - Date created - 1995-03-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synthetic surfactant scavenges oxidants and protects against hyperoxic lung injury. AN - 77719915; 7836124 AB - Injury and mortality after exposure to 100% oxygen can be diminished by surfactants that may operate by mechanisms other than those responsible for surface tension effects. We tested the hypotheses that 1) synthetic surfactant and its components function as antioxidants in vitro and 2) decrements in hyperoxic injury after treatment with a surfactant and its components are associated with decreases in oxidative stress to the lung. A synthetic surfactant (Exosurf) and its non-surface-active components tyloxapol and cetyl alcohol were incubated in an iron-containing hydroxyl radical-generating system to determine their abilities to prevent oxidation of deoxyribose. Doses of tyloxapol, cetyl alcohol, and artificial surfactant diminished the absorbance of thiobarbituric acid-reactive products of deoxyribose. Similarly, tyloxapol, cetyl alcohol, and the surfactant decreased hydroxylated products of salicylate in the same system. Rats were instilled intratracheally with saline, tyloxapol, tyloxapol plus cetyl alcohol, or artificial surfactant and immediately exposed to air or 100% oxygen. After 61 h of oxygen exposure, pleural fluid volume and wet-to-dry lung weight ratios were decreased in animals treated with surfactant and/or its components. There were also decrements in thiobarbituric acid-reactive products of lung tissue. In separate experiments, mean survival of saline-treated rats exposed to 100% oxygen was 67.3 +/- 8.1 h and > 96 h for rats given the surfactant or its components. We conclude that tyloxapol, cetyl alcohol, and Exosurf can function as antioxidants in vitro and their in vivo instillation is associated with reduction in measures of hyperoxic injury, oxidized tissue products, and mortality. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Ghio, A J AU - Fracica, P J AU - Young, S L AU - Piantadosi, C A AD - Durham Veterans Administration Medical Center, North Carolina 27710. Y1 - 1994/09// PY - 1994 DA - September 1994 SP - 1217 EP - 1223 VL - 77 IS - 3 SN - 8750-7587, 8750-7587 KW - Free Radical Scavengers KW - 0 KW - Pulmonary Surfactants KW - Reactive Oxygen Species KW - Thiobarbituric Acid Reactive Substances KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Space life sciences KW - Thiobarbituric Acid Reactive Substances -- metabolism KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Oxidative Stress -- physiology KW - Oxygen -- toxicity KW - Male KW - Reactive Oxygen Species -- metabolism KW - Hyperoxia -- prevention & control KW - Hyperoxia -- metabolism KW - Hyperoxia -- mortality KW - Pulmonary Surfactants -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77719915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Synthetic+surfactant+scavenges+oxidants+and+protects+against+hyperoxic+lung+injury.&rft.au=Ghio%2C+A+J%3BFracica%2C+P+J%3BYoung%2C+S+L%3BPiantadosi%2C+C+A&rft.aulast=Ghio&rft.aufirst=A&rft.date=1994-09-01&rft.volume=77&rft.issue=3&rft.spage=1217&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-02-28 N1 - Date created - 1995-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Technetium 94m-labeled methoxyisobutyl isonitrile: dosimetry and resting cardiac imaging with positron emission tomography. AN - 77110442; 9420726 AB - Development of a positron-emitting form of technetium has allowed the imaging of technetium radiopharmaceuticals with positron emission tomography (PET). We used 94mTc to compare the distribution of the myocardial perfusion agent sestamibi at rest with the conventional PET perfusion tracer 13N-labeled ammonia (13N-ammonia). Dosimetry calculations were performed with the known whole-body distribution of 99mTc-labeled sestamibi. Dynamic PET imaging of 13N-ammonia and 94mTc-labeled sestamibi (94mTc-sestamibi) for 32 minutes was performed in eight patients with previous myocardial infarction. Initial myocardial and extramyocardial distribution of 94mTc-sestamibi was compared with that of 13N-ammonia by qualitative and quantitative analysis. Quantitative comparison of the two tracers was performed with region-of-interest analysis and circumferential profiles. Qualitatively, the cardiac distribution of the tracers was similar in normal and infarcted myocardium. A decrease in the definition of the epicardial and endocardial borders of the heart was seen with 94mTc-sestamibi, presumably because of the lower dose of radionuclide injected. Quantitatively, there was no difference in infarct size, defined prospectively as tracer activity less than 20% of maximum activity for the section, between the two tracers. Circumferential profile analysis with 12-degree radial sections similarly demonstrated no difference in regional cardiac distribution of the tracers. These results revealed no significant difference in myocardial uptake compared with 13N-ammonia suggesting that the myocardial uptake of sestamibi correlates with that of myocardial perfusion. JF - Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology AU - Stone, C K AU - Christian, B T AU - Nickles, R J AU - Perlman, S B AD - William S. Middleton Veterans Administration Hospital/University of Wisconsin Positron Emission Tomography Center, Madison, USA. PY - 1994 SP - 425 EP - 433 VL - 1 IS - 5 Pt 1 SN - 1071-3581, 1071-3581 KW - Nitrogen Radioisotopes KW - 0 KW - Ammonia KW - 7664-41-7 KW - Technetium Tc 99m Sestamibi KW - 971Z4W1S09 KW - Index Medicus KW - Radiation Dosage KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Heart -- diagnostic imaging KW - Myocardial Infarction -- diagnostic imaging KW - Tomography, Emission-Computed UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77110442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+cardiology+%3A+official+publication+of+the+American+Society+of+Nuclear+Cardiology&rft.atitle=Technetium+94m-labeled+methoxyisobutyl+isonitrile%3A+dosimetry+and+resting+cardiac+imaging+with+positron+emission+tomography.&rft.au=Stone%2C+C+K%3BChristian%2C+B+T%3BNickles%2C+R+J%3BPerlman%2C+S+B&rft.aulast=Stone&rft.aufirst=C&rft.date=1994-09-01&rft.volume=1&rft.issue=5+Pt+1&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+cardiology+%3A+official+publication+of+the+American+Society+of+Nuclear+Cardiology&rft.issn=10713581&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1998-01-22 N1 - Date created - 1998-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential effects of carbachol on calcium entry and release in CHO cells expressing the m3 muscarinic receptor. AN - 76950323; 7828172 AB - Calcium signalling was examined in CHO-k1 cells that stably express the m3 subtype of the muscarinic receptor. The calcium indicator Fura-2 was retained in these cells only in the presence of probenecid (1 mM), suggesting that Fura-2 efflux was mediated by an organic anion transporter. The addition of carbachol (CCh) to Fura-2 loaded cells in suspension caused a rapid transient increase in intracellular calcium [Ca]i followed by a smaller sustained plateau phase. The transient rise in [Ca]i was dose-dependent with a threshold response of 89 +/- 18 nM above baseline with 10 nM CCh and a maximum stimulation of 734 +/- 46 nM with 10 microM CCh. This phase was accompanied by a similar dose-dependent stimulation of total inositol phosphate production and was assumed to be generated by release from intracellular stores of the endoplasmic reticulum (ER). The sustained increase in [Ca]i was generated by entry from the extracellular bath since it was blocked by pretreatment with La3+ (1 microM) and was absent when bath calcium was chelated with EGTA. This phase was not dependent on CCh dose, and a stimulation of [Ca]i of approximately 90 nM above baseline was observed with CCh concentrations between 50 nM and 10 microM. With this dose range, the rate of Mn2+ quenching of Fura-2 at the Ca-insensitive excitation wavelength of 360 nm was likewise maximally stimulated. At lower CCh concentrations (10-50 nM), it was clear that the activation of Ca entry could not be dissociated from a threshold release of Ca from intracellular stores. The phorbol ester PMA, which uncouples the muscarinic receptor from phospholipase C, reduced the transient rise in [Ca]i by approximately 50% with little or no effect on Ca entry at higher CCh levels (> or = 1 microM). At lower CCh concentrations (< or = 100 nM) however, pretreatment with PMA completely blocked all Ca mobilization and supports the contention that Ca entry is coupled to Ca release from stores or to store depletion. The emptying of inositol trisphosphate-sensitive stores with thapsigargin (10 nM) stimulated Ca entry and also the rate of Mn2+ quenching. Store depletion by incubation in Ca-free media likewise stimulated Mn2+ uptake without a rise in [Ca]i. Our data are therefore consistent with a 'capacitative' coupling model, whereby the activation of the plasma membrane receptor leads to an InsP3-induced change in the degree of filling of the ER Ca pool.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Cell calcium AU - Edelman, J L AU - Kajimura, M AU - Woldemussie, E AU - Sachs, G AD - Department of Medicine, Wadsworth Veterans Administration Hospital, Irvine, California. Y1 - 1994/09// PY - 1994 DA - September 1994 SP - 181 EP - 193 VL - 16 IS - 3 SN - 0143-4160, 0143-4160 KW - Inositol Phosphates KW - 0 KW - Phorbol Esters KW - Receptors, Muscarinic KW - Carbachol KW - 8Y164V895Y KW - Calcium KW - SY7Q814VUP KW - Fura-2 KW - TSN3DL106G KW - Index Medicus KW - Phorbol Esters -- pharmacology KW - Animals KW - Second Messenger Systems KW - Inositol Phosphates -- biosynthesis KW - Dose-Response Relationship, Drug KW - CHO Cells KW - Models, Biological KW - Cricetinae KW - Calcium -- metabolism KW - Receptors, Muscarinic -- biosynthesis KW - Carbachol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76950323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+calcium&rft.atitle=Differential+effects+of+carbachol+on+calcium+entry+and+release+in+CHO+cells+expressing+the+m3+muscarinic+receptor.&rft.au=Edelman%2C+J+L%3BKajimura%2C+M%3BWoldemussie%2C+E%3BSachs%2C+G&rft.aulast=Edelman&rft.aufirst=J&rft.date=1994-09-01&rft.volume=16&rft.issue=3&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Cell+calcium&rft.issn=01434160&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-02-22 N1 - Date created - 1995-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lipoprotein lipase and hepatic lipase: the role of asparagine-linked glycosylation in the expression of a functional enzyme. AN - 76917883; 7806965 AB - Lipoprotein lipase (LPL) and hepatic lipase (HL) share two conserved asparagine-linked glycosylation sites, located at the amino- and carboxy-terminal domains of the protein. Human HL contains two additional sites, preceding each conserved site by 36 and 35 amino acids, respectively. The utilization of these sites for glycan-binding and the role of each glycan chain for the catalytic function of human LPL, rat HL, and human HL was investigated. To accomplish this aim, potential Asn glycosylation sites were changed to Gln by site-directed mutagenesis and the resulting constructs were expressed in a mammalian (COS) cell system. We demonstrate the following. 1) All potential glycosylation sites in human LPL, rat HL, and human HL are utilized. 2) Lack of glycosylation at the two non-conserved sites in human HL has no effect on enzyme expression. 3) Glycosylation at the conserved Asn sites in the N-terminal domain of LPL and HL is required for the synthesis of a fully active and secreted lipase. While this is an absolute requirement for LPL, a portion (approximately 25%) of HL molecules lacking glycosylation at this essential site still becomes active and secreted. However, the simultaneous elimination of both glycosylation sites at the N-terminal domain of human HL results in the virtual abolishment of enzymatic activity and secretion. 4) Glycosylation at the conserved sites in the C-terminal domain is not essential for the expression of active lipases. 5) Eliminating all glycosylation sites in LPL and HL results in the synthesis of inactive enzymes that are retained intracellularly; however, a small portion (2%) of unglycosylated rat HL was active and secreted. We conclude that glycosylation overall plays an important role in the formation of functional LPL and HL. JF - Journal of lipid research AU - Ben-Zeev, O AU - Stahnke, G AU - Liu, G AU - Davis, R C AU - Doolittle, M H AD - Veterans Administration Wadsworth Medical Center, Los Angeles, CA 90073. Y1 - 1994/09// PY - 1994 DA - September 1994 SP - 1511 EP - 1523 VL - 35 IS - 9 SN - 0022-2275, 0022-2275 KW - DNA Primers KW - 0 KW - Asparagine KW - 7006-34-0 KW - DNA KW - 9007-49-2 KW - Lipase KW - EC 3.1.1.3 KW - Lipoprotein Lipase KW - EC 3.1.1.34 KW - Index Medicus KW - Animals KW - DNA Primers -- genetics KW - Humans KW - Gene Expression KW - Glycosylation KW - Rats KW - Mutagenesis, Site-Directed KW - Base Sequence KW - DNA -- genetics KW - Molecular Sequence Data KW - Binding Sites -- genetics KW - Asparagine -- chemistry KW - Cell Line KW - Lipase -- chemistry KW - Liver -- enzymology KW - Lipoprotein Lipase -- metabolism KW - Lipoprotein Lipase -- genetics KW - Lipase -- genetics KW - Lipoprotein Lipase -- chemistry KW - Lipase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76917883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+lipid+research&rft.atitle=Lipoprotein+lipase+and+hepatic+lipase%3A+the+role+of+asparagine-linked+glycosylation+in+the+expression+of+a+functional+enzyme.&rft.au=Ben-Zeev%2C+O%3BStahnke%2C+G%3BLiu%2C+G%3BDavis%2C+R+C%3BDoolittle%2C+M+H&rft.aulast=Ben-Zeev&rft.aufirst=O&rft.date=1994-09-01&rft.volume=35&rft.issue=9&rft.spage=1511&rft.isbn=&rft.btitle=&rft.title=Journal+of+lipid+research&rft.issn=00222275&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-01-31 N1 - Date created - 1995-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aggression and its correlates in Vietnam veterans with and without chronic posttraumatic stress disorder. AN - 76892119; 7995030 AB - This study measured self-reported aggression, hostility, and anger in Vietnam combat veterans with (n = 27) and without (n = 15) posttraumatic stress disorder (PTSD). On the Buss-Durkee Hostility Inventory, Past Feelings and Acts of Violence Scale, Episodic Dyscontrol Scale, and State-Trait Anger Expression Inventory (STAXI), PTSD subjects scored significantly higher than non-PTSD subjects, whose scores fell in the range reported for normative, noncombat populations. The PTSD versus non-PTSD group differences were not explained by combat exposure, which did not correlate significantly with the psychometric aggression measures. These findings suggest that increased aggression in war veterans is more appropriately regarded as a property of PTSD, rather than a direct consequence of military combat. The association between compromised neurologic and neuropsychologic status and the psychometric measures was modest and explained little of the group differences. JF - Comprehensive psychiatry AU - Lasko, N B AU - Gurvits, T V AU - Kuhne, A A AU - Orr, S P AU - Pitman, R K AD - Veterans Administration Medical Center, Manchester, NH 03103. PY - 1994 SP - 373 EP - 381 VL - 35 IS - 5 SN - 0010-440X, 0010-440X KW - Index Medicus KW - Substance-Related Disorders -- diagnosis KW - Irritable Mood KW - Hostility KW - Personality Inventory -- statistics & numerical data KW - Personality Assessment -- statistics & numerical data KW - Alcoholism -- diagnosis KW - Humans KW - Adult KW - Middle Aged KW - Substance-Related Disorders -- psychology KW - Psychometrics KW - Alcoholism -- psychology KW - Male KW - Anger KW - Vietnam KW - Combat Disorders -- psychology KW - Aggression -- psychology KW - Veterans -- psychology KW - Combat Disorders -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76892119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comprehensive+psychiatry&rft.atitle=Aggression+and+its+correlates+in+Vietnam+veterans+with+and+without+chronic+posttraumatic+stress+disorder.&rft.au=Lasko%2C+N+B%3BGurvits%2C+T+V%3BKuhne%2C+A+A%3BOrr%2C+S+P%3BPitman%2C+R+K&rft.aulast=Lasko&rft.aufirst=N&rft.date=1994-09-01&rft.volume=35&rft.issue=5&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Comprehensive+psychiatry&rft.issn=0010440X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-01-19 N1 - Date created - 1995-01-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acute d-amphetamine challenge in schizophrenia: effects on cerebral glucose utilization and clinical symptomatology. AN - 76888213; 7993958 AB - The effects of d-amphetamine (0.5 mg/kg orally) on regional cerebral glucose utilization were measured with positron emission tomography (PET) in 17 schizophrenics (along with a placebo-control group of an additional six schizophrenic patients). The acute d-amphetamine challenge tended to decrease glucose utilization throughout much of the brain, with a regional effect that was statistically significant in the left temporal cortex. There was no apparent relationship between the effects of amphetamine-induced changes in regional cerebral metabolism and psychotic symptom exacerbation. An exploratory analysis suggested that features characteristic of Crow's type II syndrome were significant predictors of cerebral hyporesponsivity to stimulant challenge, however. JF - Biological psychiatry AU - Wolkin, A AU - Sanfilipo, M AU - Angrist, B AU - Duncan, E AU - Wieland, S AU - Wolf, A P AU - Brodie, J D AU - Cooper, T B AU - Laska, E AU - Rotrosen, J P AD - Psychiatry Service, New York Veterans Administration Medical Center, NY. Y1 - 1994/09/01/ PY - 1994 DA - 1994 Sep 01 SP - 317 EP - 325 VL - 36 IS - 5 SN - 0006-3223, 0006-3223 KW - Blood Glucose KW - 0 KW - Dextroamphetamine KW - TZ47U051FI KW - Index Medicus KW - Temporal Lobe -- drug effects KW - Dominance, Cerebral -- physiology KW - Dominance, Cerebral -- drug effects KW - Psychiatric Status Rating Scales KW - Double-Blind Method KW - Arousal -- drug effects KW - Humans KW - Arousal -- physiology KW - Male KW - Temporal Lobe -- diagnostic imaging KW - Cerebral Cortex -- drug effects KW - Blood Glucose -- metabolism KW - Schizophrenia -- diagnostic imaging KW - Schizophrenia -- diagnosis KW - Tomography, Emission-Computed KW - Schizophrenic Psychology KW - Schizophrenia -- chemically induced KW - Cerebral Cortex -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76888213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Acute+d-amphetamine+challenge+in+schizophrenia%3A+effects+on+cerebral+glucose+utilization+and+clinical+symptomatology.&rft.au=Wolkin%2C+A%3BSanfilipo%2C+M%3BAngrist%2C+B%3BDuncan%2C+E%3BWieland%2C+S%3BWolf%2C+A+P%3BBrodie%2C+J+D%3BCooper%2C+T+B%3BLaska%2C+E%3BRotrosen%2C+J+P&rft.aulast=Wolkin&rft.aufirst=A&rft.date=1994-09-01&rft.volume=36&rft.issue=5&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-01-19 N1 - Date created - 1995-01-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exogenous nitric oxide prevents endotoxin-induced glomerular thrombosis in rats. AN - 76884976; 7996792 AB - Nitric oxide (NO) synthesized from L-arginine is an endogenous vasodilator and inhibitor of platelet adhesion and aggregation. Gram-negative lipopolysaccharide (LPS) can induce NO synthesis, which may mediate the pathophysiologic effects of endotoxemia. In addition, our previous studies suggested that LPS-induced NO may protect against thrombosis in rats. In the present study, male Sprague-Dawley rats given LPS (0.1 mg/kg) i.p. increased their urinary excretion of NO2 + NO3 (stable end-products of NO) by 4.3-fold. Rats given 10 micrograms/kg/hr i.v. of nitroglycerin (GTN), an exogenous NO donor, showed a similar increase. L-NAME, an inhibitor of NO synthesis, abrogated the increase in urinary NO2 + NO3 in LPS-treated rats but not in rats given GTN. Glomerular thrombosis developed in rats given LPS + L-NAME (thrombosis score = 3.02 +/- 0.4), while those given LPS + L-NAME + GTN were largely protected (thrombosis score = 1.37 +/- 0.5, P < 0.05). Atrial natriuretic peptide (ANP), an NO-independent vasodilator, neither increased urinary NO2 + NO3 nor prevented glomerular thrombosis (thrombosis score = 2.68 +/- 0.5, NS). Hydralazine, another vasodilator without effects on NO or platelets, also failed to prevent glomerular thrombosis in rats given LPS + L-NAME. We conclude that in endotoxemia, the antithrombogenic properties of endogenously synthesized NO are important in preventing alomerular thrombosis. The exogenously NO donor, GTN, can substitute for the antithrombogenic effect of endogenous NO. Clinically, administration of NO synthesis inhibitors to treat endotoxic shock may need to be combined with concomitant administration of exogenous NO donors to prevent microvascular thrombosis. JF - Kidney international AU - Westberg, G AU - Shultz, P J AU - Raij, L AD - Department of Medicine, Veterans Administration Medical Center, Minneapolis, Minnesota. Y1 - 1994/09// PY - 1994 DA - September 1994 SP - 711 EP - 716 VL - 46 IS - 3 SN - 0085-2538, 0085-2538 KW - Lipopolysaccharides KW - 0 KW - Nitric Oxide KW - 31C4KY9ESH KW - Arginine KW - 94ZLA3W45F KW - Nitroglycerin KW - G59M7S0WS3 KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Nitroglycerin -- pharmacology KW - Blood Pressure KW - Arginine -- toxicity KW - Lipopolysaccharides -- toxicity KW - Arginine -- analogs & derivatives KW - Male KW - Thrombosis -- prevention & control KW - Kidney Diseases -- pathology KW - Thrombosis -- pathology KW - Nitric Oxide -- antagonists & inhibitors KW - Thrombosis -- etiology KW - Nitric Oxide -- pharmacology KW - Kidney Diseases -- prevention & control KW - Kidney Diseases -- etiology KW - Kidney Glomerulus -- pathology KW - Kidney Glomerulus -- blood supply UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76884976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Exogenous+nitric+oxide+prevents+endotoxin-induced+glomerular+thrombosis+in+rats.&rft.au=Westberg%2C+G%3BShultz%2C+P+J%3BRaij%2C+L&rft.aulast=Westberg&rft.aufirst=G&rft.date=1994-09-01&rft.volume=46&rft.issue=3&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-01-18 N1 - Date created - 1995-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - HIV infection and surgeons. AN - 76848338; 7975695 AB - The human immunodeficiency virus (HIV) causes acquired immunodeficiency syndrome, which remains uniformly fatal in affected individuals. A common route of HIV transmission is via inoculation of contaminated blood, which may occur during surgical procedures. Surgeons may estimate their risk of HIV infection over a 30-year surgical career based on HIV prevalence among surgical patients, percutaneous injury rate per operation, and seroconversion rate. Surgeons can reduce their risk by various means, but the most pragmatic is by reducing the rate of percutaneous injury through optimal surgical technique and proper precautions. JF - World journal of surgery AU - Lin, E Y AU - Brunicardi, F C AD - Department of Surgery, Veterans Administration Medical Center-West Los Angeles, CA 90073. PY - 1994 SP - 753 EP - 757 VL - 18 IS - 5 SN - 0364-2313, 0364-2313 KW - Index Medicus KW - AIDS/HIV KW - Acquired Immunodeficiency Syndrome -- epidemiology KW - Risk Factors KW - Humans KW - Health Personnel KW - Prevalence KW - Occupational Exposure KW - HIV Infections -- transmission KW - Infectious Disease Transmission, Patient-to-Professional KW - General Surgery KW - HIV Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76848338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=World+journal+of+surgery&rft.atitle=HIV+infection+and+surgeons.&rft.au=Lin%2C+E+Y%3BBrunicardi%2C+F+C&rft.aulast=Lin&rft.aufirst=E&rft.date=1994-09-01&rft.volume=18&rft.issue=5&rft.spage=753&rft.isbn=&rft.btitle=&rft.title=World+journal+of+surgery&rft.issn=03642313&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-12-29 N1 - Date created - 1994-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Randomized comparison trial of teicoplanin i.v., teicoplanin i.m., and cefazolin therapy for skin and soft tissue infections caused by gram-positive bacteria. AN - 76725200; 8091249 AB - Teicoplanin, a glycopeptide antibiotic chemically related to the vancomycin-ristocetin group of antibiotics, has potent activity against aerobic and anaerobic gram-positive bacteria. In this study, we examined the efficacy and safety of teicoplanin for parenteral treatment of skin and soft tissue infections caused by gram-positive bacteria. Ninety-six hospitalized adults with moderate to severe skin and soft tissue infections were randomized to receive either teicoplanin intravenously (i.v.) once a day, teicoplanin intramuscularly (i.m.) once a day, or cefazolin i.v. every 8 hours. We evaluated patients' clinical and microbiologic status and assessed clinical and laboratory adverse events. Of 76 clinically assessable patients, 26 of 26 (100%) given teicoplanin i.v., 21 of 22 (95%) given teicoplanin i.m., and 26 of 28 (93%) given cefazolin showed improvement or cure. Of 60 microbiologically assessable patients, 22 of 22 (100%) given teicoplanin i.v., 16 of 18 (89%) given teicoplanin i.m, and 18 of 20 (90%) given cefazolin were cured. Of 96 patients assessable for adverse events, 7 of 34 (21%) given teicoplanin i.v., 4 of 31 (13%) give teicoplanin i.m., and 1 of 31 (3%) given cefazolin had adverse events. In this study, once daily teicoplanin appeared to be safe and effective therapy for skin and soft tissue infections. JF - Southern medical journal AU - Chirurgi, V A AU - Edelstein, H AU - Oster, S E AU - Karp, R AU - Cassano, K B AU - Aiken, S AU - McCabe, R E AD - Medical Service, Veterans Administration Medical Center, Martinez, CA 94553. Y1 - 1994/09// PY - 1994 DA - September 1994 SP - 875 EP - 880 VL - 87 IS - 9 SN - 0038-4348, 0038-4348 KW - Teicoplanin KW - 61036-62-2 KW - Cefazolin KW - IHS69L0Y4T KW - Abridged Index Medicus KW - Index Medicus KW - Injections, Intravenous KW - Humans KW - Injections, Intramuscular KW - Treatment Outcome KW - Middle Aged KW - Male KW - Female KW - Skin Diseases, Bacterial -- drug therapy KW - Connective Tissue Diseases -- drug therapy KW - Teicoplanin -- therapeutic use KW - Teicoplanin -- adverse effects KW - Gram-Positive Bacterial Infections -- drug therapy KW - Cefazolin -- adverse effects KW - Cefazolin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76725200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Randomized+comparison+trial+of+teicoplanin+i.v.%2C+teicoplanin+i.m.%2C+and+cefazolin+therapy+for+skin+and+soft+tissue+infections+caused+by+gram-positive+bacteria.&rft.au=Chirurgi%2C+V+A%3BEdelstein%2C+H%3BOster%2C+S+E%3BKarp%2C+R%3BCassano%2C+K+B%3BAiken%2C+S%3BMcCabe%2C+R+E&rft.aulast=Chirurgi&rft.aufirst=V&rft.date=1994-09-01&rft.volume=87&rft.issue=9&rft.spage=875&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-10-18 N1 - Date created - 1994-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Research Champions: Translating Research and Reinventing Governmental Health Care AN - 61627285; 199502836 AB - The US federal government has played a key role in the evolution of health care research in the twentieth century, providing support for training investigators, building facilities, & conducting research into the causes & cures of diseases. However, only recently has there been significant work on the delivery of health care services. Here, a case study is presented of the role of active leadership in translating research results into improved health care at the US Dept of Veterans Affairs. 18 References. Adapted from the source document. JF - Science Communication AU - Meehan, Shirley AU - Valentine, John A AD - Health Services Research & Development Service Veterans Administration Central Office, 810 Vermont Ave NW Washington DC 20420 Y1 - 1994/09// PY - 1994 DA - September 1994 SP - 90 EP - 101 VL - 16 IS - 1 SN - 1075-5470, 1075-5470 KW - health care services, research contributions KW - case study KW - US Department of Veterans Affairs KW - Veterans KW - Health Care KW - Health Services KW - United States of America KW - Federal Government KW - article KW - 7211: social planning/policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61627285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+Communication&rft.atitle=Research+Champions%3A+Translating+Research+and+Reinventing+Governmental+Health+Care&rft.au=Meehan%2C+Shirley%3BValentine%2C+John+A&rft.aulast=Meehan&rft.aufirst=Shirley&rft.date=1994-09-01&rft.volume=16&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Science+Communication&rft.issn=10755470&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health Services; United States of America; Federal Government; Health Care; Veterans ER - TY - JOUR T1 - Developmental mechanics explains long bone scaling AN - 52869053; 1996-024993 JF - Journal of Vertebrate Paleontology AU - van der Meulen, Marjolein C H AU - Carter, Dennis R AU - Padian, Kevin Y1 - 1994/09// PY - 1994 DA - September 1994 SP - 50 EP - 51 PB - University of Oklahoma, Norman, OK VL - 14 IS - 3, Suppl. SN - 0272-4634, 0272-4634 KW - morphology KW - Chordata KW - biometry KW - strain KW - mechanics KW - mathematical models KW - biologic evolution KW - Vertebrata KW - extremities KW - concepts KW - geometry KW - 11:Vertebrate paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52869053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Vertebrate+Paleontology&rft.atitle=Developmental+mechanics+explains+long+bone+scaling&rft.au=van+der+Meulen%2C+Marjolein+C+H%3BCarter%2C+Dennis+R%3BPadian%2C+Kevin&rft.aulast=van+der+Meulen&rft.aufirst=Marjolein+C&rft.date=1994-09-01&rft.volume=14&rft.issue=3%2C+Suppl.&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Journal+of+Vertebrate+Paleontology&rft.issn=02724634&rft_id=info:doi/ L2 - http://www.bioone.org/loi/vrpa LA - English DB - GeoRef N1 - Conference title - Society of Vertebrate Paleontology, Fifty-fourth annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 1996-01-01 N1 - PubXState - OK N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - biologic evolution; biometry; Chordata; concepts; extremities; geometry; mathematical models; mechanics; morphology; strain; Vertebrata ER - TY - JOUR T1 - Comparison of the effectiveness of tetracycline and minocycline as pleural sclerosing agents in rabbits. AN - 77098400; 7774340 AB - Parenteral tetracycline, one of the most commonly used agents for producing pleurodesis, is no longer available because of stricter regulations governing the manufacturing process. The objective of this project was to determine whether minocycline, a tetracycline derivative, is an effective sclerosant in an experimental model in rabbits. We also studied the relationship of the dose and the volume injected to the degree of pleurodesis. The following medications were instilled intrapleurally in anesthetized male rabbits: tetracycline, 35 mg/kg; or minocycline, 4, 7, 10, or 20 mg/kg, diluted to a total volume of 1 or 2 ml of bacteriostatic saline solution; or minocycline, 40 mg/kg, diluted to a total volume of 2 ml of the solution. Twenty-eight days after the instillation, the animals were killed. The pleural spaces were assessed grossly for evidence of pleurodesis and microscopically for evidence of fibrosis and inflammation. The degree of pleurodesis grossly and microscopically after the injection of 7, 10, 20, or 40 mg/kg of minocycline was comparable to that after the injection of 35 mg/kg of tetracycline, while the dose of 4 mg/kg was less effective. In the animals who received the higher doses of minocycline intrapleurally (ie > or = 20 mg/kg), there was an excess mortality both early (chi 2 = 3.61, 0.05 or = 20 mg/kg) produce a high mortality that seems to be related to hemothorax. Since, in humans, a large experience confirms only 20 mg/kg of tetracycline is needed to produce adequate pleurodesis safely, we recommend a dose of 4 mg/kg of minocycline for the production of pleurodesis. JF - Chest AU - Light, R W AU - Wang, N S AU - Sassoon, C S AU - Gruer, S E AU - Vargas, F S AD - Department of Medicine, Veterans Administration Medical Center, Long Beach, Calif. 90822, USA. Y1 - 1994/08// PY - 1994 DA - August 1994 SP - 577 EP - 582 VL - 106 IS - 2 SN - 0012-3692, 0012-3692 KW - Tetracycline KW - F8VB5M810T KW - Minocycline KW - FYY3R43WGO KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Hemothorax -- etiology KW - Rabbits KW - Male KW - Minocycline -- administration & dosage KW - Tetracycline -- administration & dosage KW - Pleurodesis -- methods KW - Pleurodesis -- adverse effects KW - Minocycline -- adverse effects KW - Tetracycline -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77098400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Comparison+of+the+effectiveness+of+tetracycline+and+minocycline+as+pleural+sclerosing+agents+in+rabbits.&rft.au=Light%2C+R+W%3BWang%2C+N+S%3BSassoon%2C+C+S%3BGruer%2C+S+E%3BVargas%2C+F+S&rft.aulast=Light&rft.aufirst=R&rft.date=1994-08-01&rft.volume=106&rft.issue=2&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-07-11 N1 - Date created - 1995-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment of murine lupus with monoclonal antibodies to lymphocyte function-associated antigen-1: dose-dependent inhibition of autoantibody production and blockade of the immune response to therapy. AN - 76631041; 8050193 AB - Monoclonal antibodies (mAb) to lymphocyte function-associated antigen-1 (LFA-1) have been used successfully in vivo to inhibit immune responses and to block inflammatory reactions. To determine whether these effects of anti-LFA-1 could retard autoimmune disease, we treated lupus-prone NZB/NZW F1 (B/W) mice with a rat mAb to LFA-1 (anti-CD11a). Mice received high-dose therapy (500 micrograms twice weekly), low-dose therapy (40 micrograms thrice weekly), or phosphate-buffered saline from age 5 months to age 10 months. Treatment with high doses of anti-CD11a suppressed both the immune response to the rat mAb and the production of autoantibodies to double-stranded DNA. In contrast, treatment with low doses of anti-CD11a elicited an immune response to the rat mAb and did not suppress autoantibody production. The immunosuppressive effects of high doses of anti-CD11a were not due to target cell depletion. In fact, treatment induced a marked lymphocytosis which involved all lymphocyte subsets equally. Despite inhibiting autoantibody production, high-dose therapy had only modest effects on longevity. JF - Clinical immunology and immunopathology AU - Connolly, M K AU - Kitchens, E A AU - Chan, B AU - Jardieu, P AU - Wofsy, D AD - Arthritis/Immunology Section, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1994/08// PY - 1994 DA - August 1994 SP - 198 EP - 203 VL - 72 IS - 2 SN - 0090-1229, 0090-1229 KW - Antibodies, Monoclonal KW - 0 KW - Autoantibodies KW - Lymphocyte Function-Associated Antigen-1 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Immunotherapy KW - Lymphocytosis -- chemically induced KW - Autoimmune Diseases -- etiology KW - Lymphocyte Subsets -- drug effects KW - Disease Models, Animal KW - Mice KW - Rats KW - Mice, Inbred Strains KW - Autoimmunity -- physiology KW - Lymphocytosis -- immunology KW - DNA -- immunology KW - Lymphocyte Subsets -- immunology KW - Autoimmune Diseases -- immunology KW - Lymphocyte Function-Associated Antigen-1 -- immunology KW - Lupus Vulgaris -- therapy KW - Autoantibodies -- biosynthesis KW - Lymphocyte Function-Associated Antigen-1 -- physiology KW - Lupus Vulgaris -- immunology KW - Lymphocyte Function-Associated Antigen-1 -- pharmacology KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76631041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+immunology+and+immunopathology&rft.atitle=Treatment+of+murine+lupus+with+monoclonal+antibodies+to+lymphocyte+function-associated+antigen-1%3A+dose-dependent+inhibition+of+autoantibody+production+and+blockade+of+the+immune+response+to+therapy.&rft.au=Connolly%2C+M+K%3BKitchens%2C+E+A%3BChan%2C+B%3BJardieu%2C+P%3BWofsy%2C+D&rft.aulast=Connolly&rft.aufirst=M&rft.date=1994-08-01&rft.volume=72&rft.issue=2&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=Clinical+immunology+and+immunopathology&rft.issn=00901229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-09-02 N1 - Date created - 1994-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - RPRT T1 - VETERANS AFFAIRS MEDICAL AND REGIONAL OFFICE CENTER, TRIPLER ARMY MEDICAL CENTER, OAHU, HONOLULU COUNTY, HAWAII. AN - 36408606; 4726 AB - PURPOSE: The construction of a Veterans Affairs medical and regional office center at Tripler Army Medical Center in Oahu, Hawaii, is proposed. The center would provide overall medical services to the growing veteran population in Hawaii. The Department of Veterans Affairs (VA) does not have a hospital, nursing home, or state veterans home in Hawaii; as a result, services have been fragmented and dispersed among a variety of facilities scattered throughout the community. The center would provide medical care for an estimated 91,800 outpatient visits annually by the year 2005. The major components of the center would include the 105-bed medical center, a 60-bed nursing home, and the renovation of a present wing (E-wing) of Tripler Hospital in order to house the VA's regional office. The medical center would be housed in a 326,800-square-foot, five-story structure that would function as the main medical facility, with three levels of ancillary/outpatient services and two inpatient levels. The medical center would be staffed by 704 full-time employees. The Center for Aging would be housed in a 42,700-square-foot, single-story building with 63 on-site parking spaces; it would employ 50 persons. Four of the five stories of the hospital's E-wing would be renovated to accommodate the VA's administrative and engineering offices, the Veterans Benefit Administration, vocational rehabilitation and counseling services, and various veterans service organizations. These activities are currently located in a federal building in downtown Honolulu. An estimated 230 persons would be employed in this portion of the facility. The project would also provide 979 parking spaces in several modes and locations to accommodate visitors, patients, and staff. POSITIVE IMPACTS: The facility would consolidate, centralize, and expand the VA's health and benefit services in Hawaii. Sharing staff and services with Tripler Hospital would help to eliminate duplicative staff and services and reduce operating costs for both the VA and the Army. NEGATIVE IMPACTS: The facility would significantly increase traffic congestion at three key intersections. Perched ground water could be encountered at the project site during construction. Although dewatering activities would be minimal, the implementation of control measures could be necessary in order to protect against the discharges of dewatering effluent. LEGAL MANDATES: Federal Water Pollution Control Act of 1972 (33 U.S.C. 1251 et seq.). JF - EPA number: 940268, 355 pages and maps, July 7, 1994 PY - 1994 KW - Urban and Social Programs KW - Buildings KW - Employment KW - Hospitals KW - Land Use KW - Parking KW - Traffic Analyses KW - Water Quality KW - Hawaii KW - Tripler Army Medical Center, Hawaii KW - Federal Water Pollution Control Act of 1972, NPDES Permits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36408606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=1994-07-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=VETERANS+AFFAIRS+MEDICAL+AND+REGIONAL+OFFICE+CENTER%2C+TRIPLER+ARMY+MEDICAL+CENTER%2C+OAHU%2C+HONOLULU+COUNTY%2C+HAWAII.&rft.title=VETERANS+AFFAIRS+MEDICAL+AND+REGIONAL+OFFICE+CENTER%2C+TRIPLER+ARMY+MEDICAL+CENTER%2C+OAHU%2C+HONOLULU+COUNTY%2C+HAWAII.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Veterans Affairs, Veterans Health Administration, Washington, District of Columbia; VA N1 - Date revised - 2006-05-01 N1 - SuppNotes - Draft. Preparation date: July 7, 1994 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Healing of NSAID-induced gastric ulcers with a synthetic prostaglandin analog (enprostil). AN - 85226814; pmid-8017358 AB - OBJECTIVE: Conventional ulcer therapy has not been proven effective in healing gastric ulcers caused by nonsteroidal anti-inflammatory drugs (NSAIDs) if the NSAIDs are continued. Our objective in this study was to determine whether a prostaglandin analog is an effective treatment for such NSAID-induced lesions. METHODS: To make this determination, we conducted a 9-wk double-blind trial comparing placebo with enprostil 35 micrograms twice daily and three times daily. Use of antacids was not allowed. Three centers entered 145 patients with chronic inflammatory arthritis and osteoarthritis, mean age 63 yr, who required continuous fixed-dose NSAID therapy within the range of therapeutic dosage. The minimum entrance criterion was the presence of either four gastric erosions or one gastric ulcer. Two pretreatment endoscopies within a 2-wk interval were performed to establish the presence of stable baseline gastric lesions. Endoscopy was repeated at wk 6 and 9 during treatment. All groups were similar with regard to age distribution, sex, weight, height, smoking usage, and alcohol consumption. RESULTS: The ulcer healing rates were 14%, 57%, and 68% at 6 wk and 19%, 68%, and 74% at 9 wk for the groups receiving placebo, enprostil twice daily, and enprostil three times daily, respectively (p < 0.01). Complete mucosal healing of all erosions and ulcers at 9 wk occurred in 59% of enprostil-treated patients and in 10% of placebo-treated patients. Additional gastric erosions and gastric ulcers developed in 16% of placebo patients and 4% of the enprostil patients. Eighteen percent of enprostil patients withdrew early from the study due to adverse experiences, such as diarrhea and abdominal pain. CONCLUSION: We concluded that during continued NSAID therapy 1) enprostil 35 micrograms (taken either twice daily or three times daily) heals NSAID-induced gastric ulcers and erosions and protects the mucosa from further NSAID-induced gastric injury; 2) gastric ulcers and erosions rarely heal spontaneously, and 3) enprostil results in a high incidence of diarrhea. JF - The American Journal of Gastroenterology AU - Sontag, S J AU - Schnell, T G AU - Budiman-Mak, E AU - Adelman, K AU - Fleischmann, R AU - Cohen, S AU - Roth, S H AU - Ipe, D AU - Schwartz, K E AD - Department of Ambulatory Care, Veterans Administration Hospital, Hines, Illinois. PY - 1994 SP - 1014 EP - 1020 VL - 89 IS - 7 SN - 0002-9270, 0002-9270 KW - Stomach Ulcer KW - Double-Blind Method KW - Enprostil KW - Osteoarthritis KW - Human KW - Arthritis, Rheumatoid KW - Aged KW - Gastric Mucosa KW - Middle Age KW - Support, Non-U.S. Gov't KW - Anti-Inflammatory Agents, Non-Steroidal KW - Male KW - Female UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85226814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Healing+of+NSAID-induced+gastric+ulcers+with+a+synthetic+prostaglandin+analog+%28enprostil%29.&rft.au=Sontag%2C+S+J%3BSchnell%2C+T+G%3BBudiman-Mak%2C+E%3BAdelman%2C+K%3BFleischmann%2C+R%3BCohen%2C+S%3BRoth%2C+S+H%3BIpe%2C+D%3BSchwartz%2C+K+E&rft.aulast=Sontag&rft.aufirst=S&rft.date=1994-07-01&rft.volume=89&rft.issue=7&rft.spage=1014&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - High-risk behaviors for HIV: a comparison between crack-abusing and opioid-abusing African-American women. AN - 77713779; 7844652 AB - High rates of unprotected sexual behaviors and the exchange of sex for crack have been reported among female crack cocaine users. This subpopulation of drug users is at significant risk for contracting and transmitting HIV and AIDS. To date, there has been no research comparing crack- and opioid-abusing women, particularly regarding their involvement in high-risk behaviors and other key background indicators for different subgroups of drug-abusing women. Sixty-one crack-abusing African-American women who recently entered an intensive outpatient treatment program were compared to 64 matched women whose primary drug of abuse was heroin. The opioid subgroup represented both those who were involved in methadone maintenance and those who were out of treatment. Higher rates of high-risk sexual behaviors were reported by the crack subgroup, including prostitution, number of sexual partners, and infrequency of condom use. As expected, i.v. drug use and high-risk behaviors associated with needle use were much higher among the opioid subgroup. Other significant differences were found between the two groups across key indicators. Individuals in the crack subgroup were younger, cared for more children, were less employable, were less likely to be married, and had more extensive lifetime substance abuse. Quantitative and qualitative background and clinical data are also presented. The nature of crack versus heroin abuse is also discussed, particularly in relation to high-risk sexual behaviors. Finally, the impact of the findings on developing appropriate treatment interventions for both groups is addressed. JF - Journal of psychoactive drugs AU - Cohen, E AU - Navaline, H AU - Metzger, D AD - University of Pennsylvania/Veterans Administration Medical Center, Center for Studies of Addiction, Philadelphia 19104. PY - 1994 SP - 233 EP - 241 VL - 26 IS - 3 SN - 0279-1072, 0279-1072 KW - Crack Cocaine KW - 0 KW - Narcotics KW - Index Medicus KW - AIDS/HIV KW - United States KW - Socioeconomic Factors KW - Sexual Behavior KW - Contraception Behavior KW - Humans KW - Adult KW - Sex Work KW - Adolescent KW - Female KW - Substance Abuse, Intravenous -- psychology KW - Risk-Taking KW - HIV Infections -- transmission KW - African Americans -- psychology KW - Substance-Related Disorders -- psychology KW - HIV Infections -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77713779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=High-risk+behaviors+for+HIV%3A+a+comparison+between+crack-abusing+and+opioid-abusing+African-American+women.&rft.au=Cohen%2C+E%3BNavaline%2C+H%3BMetzger%2C+D&rft.aulast=Cohen&rft.aufirst=E&rft.date=1994-07-01&rft.volume=26&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-03-07 N1 - Date created - 1995-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mitotic arrest with anti-microtubule agents or okadaic acid is associated with increased glycoprotein terminal GlcNAc's. AN - 76866484; 7527049 AB - The two major intermediate filament glycoproteins in human simple epithelia are keratins 8 and 18 (K8/18). A dramatic increase in terminal N-acetylglucosamine (GlcNAc) residues in K8/18 was previously noted after arresting cells in G2/M using anti-microtubule agents. Here we use in vitro galactosylation to show that increased terminal GlcNAc's is a general phenomenon that occurs in glycoproteins isolated from nuclear and plasma membrane fractions after cells are arrested in mitosis using colcemid, nocodazole, or okadaic acid. All three agents also resulted in a hyperphosphorylated form of K8 as determined by phosphatase treatment and tryptic phosphopeptide mapping. The altered glycosylation was found to be independent of microtubule disassembly, and was not directly related to the G2/M phase of the cell cycle after aphidicolin synchronization. Staurosporine (1 microM) inhibited K8/18 phosphorylation in okadaic acid- or nocodazole-treated cells, and inhibited the increase in K8/18 glycosylation without inhibiting the increase in terminal GlcNAc's of membrane-associated glycoproteins. In contrast, brefeldin A resulted in a dramatic increase in terminal GlcNAc's of membrane-associated but not intermediate filament proteins. Golgi complex-related staining using anti-beta-COP antibody showed significant fragmentation under conditions associated with altered membrane protein glycosylation. Our results suggest that Golgi disruption may be involved in the observed increase in terminal GlcNAc's of membrane but not intermediate filament glycoproteins. The mechanism of increased glycoprotein terminal GlcNAc's in association with mitotic arrest appears to be distinct for intermediate filaments and membrane-associated proteins, and in the case of intermediate filament proteins, phosphorylation may play an important role. Some of the effects of agents that induce mitotic arrest may be mediated by glycosylation changes. JF - Journal of cell science AU - Chou, C F AU - Omary, M B AD - Palo Alto Veterans Administration Medical Center, CA. Y1 - 1994/07// PY - 1994 DA - July 1994 SP - 1833 EP - 1843 VL - 107 ( Pt 7) SN - 0021-9533, 0021-9533 KW - Alkaloids KW - 0 KW - Cyclopentanes KW - Ethers, Cyclic KW - Glycoproteins KW - Protein Synthesis Inhibitors KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Brefeldin A KW - 20350-15-6 KW - Aphidicolin KW - 38966-21-1 KW - Keratins KW - 68238-35-7 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Acid Phosphatase KW - EC 3.1.3.2 KW - Staurosporine KW - H88EPA0A3N KW - Nocodazole KW - SH1WY3R615 KW - Acetylglucosamine KW - V956696549 KW - Index Medicus KW - Acid Phosphatase -- pharmacology KW - HeLa Cells KW - Humans KW - Golgi Apparatus -- drug effects KW - Glycosylation KW - Nocodazole -- pharmacology KW - Aphidicolin -- pharmacology KW - Protein Kinase C -- antagonists & inhibitors KW - Cyclopentanes -- pharmacology KW - Protein Synthesis Inhibitors -- pharmacology KW - Colon KW - Golgi Apparatus -- ultrastructure KW - Alkaloids -- pharmacology KW - Epithelium -- metabolism KW - G2 Phase KW - Golgi Apparatus -- metabolism KW - Cell Cycle -- drug effects KW - Cell Line KW - Keratins -- metabolism KW - Glycoproteins -- metabolism KW - Glycoproteins -- chemistry KW - Acetylglucosamine -- analysis KW - Acetylglucosamine -- metabolism KW - Mitosis -- drug effects KW - Keratins -- chemistry KW - Microtubules -- drug effects KW - Ethers, Cyclic -- pharmacology KW - Mitosis -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76866484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cell+science&rft.atitle=Mitotic+arrest+with+anti-microtubule+agents+or+okadaic+acid+is+associated+with+increased+glycoprotein+terminal+GlcNAc%27s.&rft.au=Chou%2C+C+F%3BOmary%2C+M+B&rft.aulast=Chou&rft.aufirst=C&rft.date=1994-07-01&rft.volume=107+%28+Pt+7%29&rft.issue=&rft.spage=1833&rft.isbn=&rft.btitle=&rft.title=Journal+of+cell+science&rft.issn=00219533&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-01-04 N1 - Date created - 1995-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Asbestos content of bronchoalveolar lavage fluid. A comparison of light and scanning electron microscopic analysis. AN - 76605292; 8042413 AB - We studied the asbestos content of bronchoalveolar lavage fluid (BALF) from 9 patients with asbestosis, 17 asbestos exposed but without asbestosis, 15 with idiopathic pulmonary fibrosis (IPF) and 9 nonexposed volunteers. The cellular lavage pellet was digested and filtered for asbestos body (AB) quantification by light microscopy (LM) and analysis of numbers and types of uncoated fibers (UF) by scanning electron microscopy (SEM) and energy dispersive x-ray analysis. BALF of asbestosis patients had significantly higher AB content than that of the combined IPF and volunteer groups. The UF content as determined by SEM was similar in all four groups. Commercial amphiboles (amosite or crocidolite) were identified more frequently in BALF from patients with asbestosis than from the other groups. ABs were detected by SEM only in highly exposed individuals. We conclude that the findings of > 1 AB per 10(6) cells or 1 AB/mL BALF by LM and of ABs or commercial amphibole fibers by SEM are indicative of considerable exposure to asbestos in the majority of cases. JF - Acta cytologica AU - Roggli, V L AU - Coin, P G AU - MacIntyre, N R AU - Bell, D Y AD - Department of Pathology, Durham Veterans Administration, North Carolina. PY - 1994 SP - 502 EP - 510 VL - 38 IS - 4 SN - 0001-5547, 0001-5547 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Microscopy, Electron, Scanning KW - Asbestos -- analysis KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Lung Diseases, Interstitial -- diagnosis KW - Asbestosis -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76605292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+cytologica&rft.atitle=Asbestos+content+of+bronchoalveolar+lavage+fluid.+A+comparison+of+light+and+scanning+electron+microscopic+analysis.&rft.au=Roggli%2C+V+L%3BCoin%2C+P+G%3BMacIntyre%2C+N+R%3BBell%2C+D+Y&rft.aulast=Roggli&rft.aufirst=V&rft.date=1994-07-01&rft.volume=38&rft.issue=4&rft.spage=502&rft.isbn=&rft.btitle=&rft.title=Acta+cytologica&rft.issn=00015547&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-08-24 N1 - Date created - 1994-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Homeless Women, Disaffiliation and Social Agencies AN - 61372369; 9504549 AB - Explores the relationship between homelessness, gender, & social agencies via interviews with 102 homeless individuals staying in shelters in Chicago, IL. Perceived level of support from friends, family, & social agencies was rated using a Likert-type scale. Findings show a higher level of perceived support by males than by females, particularly from social agencies. Age, presence of psychiatric illness, & length of time homeless did not affect findings. Implications for public policy are discussed. 3 Tables, 23 References. Adapted from the source document. JF - The International Journal of Social Psychiatry AU - Stovall, Jeffrey AU - Flaherty, Joseph AD - Dept Psychiatry Westside Veterans Administration Medical Center, 820 South Damen Ave Chicago IL 60612 Y1 - 1994/07// PY - 1994 DA - July 1994 SP - 135 EP - 140 VL - 40 IS - 2 SN - 0020-7640, 0020-7640 KW - perceived social agency support, female vs male homeless KW - interview data KW - Chicago, Illinois KW - Perceptions KW - Social Agencies KW - Sex Differences KW - Social Support KW - Homelessness KW - article KW - 2793: studies in poverty; homelessness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61372369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+Journal+of+Social+Psychiatry&rft.atitle=Homeless+Women%2C+Disaffiliation+and+Social+Agencies&rft.au=Stovall%2C+Jeffrey%3BFlaherty%2C+Joseph&rft.aulast=Stovall&rft.aufirst=Jeffrey&rft.date=1994-07-01&rft.volume=40&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=The+International+Journal+of+Social+Psychiatry&rft.issn=00207640&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - IJSPAG N1 - SubjectsTermNotLitGenreText - Chicago, Illinois; Homelessness; Sex Differences; Social Agencies; Social Support; Perceptions ER - TY - JOUR T1 - Topological analysis of H+,K(+)-ATPase using in vitro translation. AN - 76537545; 8207013 AB - The membrane topology of the alpha subunit of the H+,K(+)-ATPase was investigated by using in vitro transcription/translation of DNA sequences encoding fusion proteins that contained possible membrane-spanning segments. The vectors consisted of DNA sequences encoding (a) either the first 101 (M0 vectors) or the first 139 (M1 vectors) amino acids of the N-terminal region of the alpha subunit of the ATPase, (b) a variable region, and then (c) the C-terminal 177 amino acids of the C-terminal region of the beta subunit, with five N-linked glycosylation sites. The variable region of the fusion protein contained the cDNA sequences representing the possible eight or 10 membrane-spanning segments either alone or in various combinations. Transcription/translation was performed in the presence of [35S]methionine using a coupled reticulocyte lysate in the absence and presence of microsomes. The fusion protein was identified by autoradiography following separation using SDS-polyacrylamide gel electrophoresis. Glycosylation of a translated sequence corresponded to membrane insertion and translocation of the C-terminal beta sequence. This method allowed analysis of signal anchor sequences using the M0 vector. The presence of a stop transfer sequence in the variable segment of the M1 vector resulted in inhibition of translocation of the C-terminal beta sequence. The sequences for the first four membrane segments could act as either signal anchor or stop transfer sequences. Therefore, this region of the alpha subunit has four membrane-spanning segments that are co-inserted with translation. The sequence corresponding to membrane segment M8 acted as a stop transfer sequence. The sequence corresponding to membrane segment M9 acted as a signal anchor sequence, and that corresponding to membrane segment M10 acted as a stop transfer sequence. The sequences representing the fifth, sixth, and seventh (M5, M6, and M7) membrane segments were unable to co-insert into the membrane. These data verify the first four and the eight membrane-spanning segments of the alpha subunit of the gastric H+,K(+)-ATPase and provide evidence for translational insertion of an additional pair of membrane-spanning segments, M9 and M10. It appears that insertion of membrane segments M5, M6, and M7 is determined differently from the other membrane-spanning segments. In combination with other methods, this in vitro transcription/translation method is useful for defining the membrane topology of the P type ATPases. JF - The Journal of biological chemistry AU - Bamberg, K AU - Sachs, G AD - Wadsworth Veterans Administration, Los Angeles, California 90073. Y1 - 1994/06/17/ PY - 1994 DA - 1994 Jun 17 SP - 16909 EP - 16919 VL - 269 IS - 24 SN - 0021-9258, 0021-9258 KW - DNA Primers KW - 0 KW - Macromolecular Substances KW - Recombinant Fusion Proteins KW - Recombinant Proteins KW - H(+)-K(+)-Exchanging ATPase KW - EC 3.6.3.10 KW - Index Medicus KW - Recombinant Fusion Proteins -- biosynthesis KW - Animals KW - Recombinant Proteins -- biosynthesis KW - Transcription, Genetic KW - Amino Acid Sequence KW - Rabbits KW - Recombinant Fusion Proteins -- chemistry KW - Binding Sites KW - Cloning, Molecular KW - Polymerase Chain Reaction KW - Base Sequence KW - Genetic Vectors KW - Restriction Mapping KW - Molecular Sequence Data KW - Recombinant Proteins -- chemistry KW - Mutagenesis, Insertional KW - Sequence Deletion KW - Protein Biosynthesis KW - Protein Structure, Secondary KW - Cell Membrane -- enzymology KW - H(+)-K(+)-Exchanging ATPase -- biosynthesis KW - Cell Membrane -- ultrastructure KW - H(+)-K(+)-Exchanging ATPase -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76537545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Topological+analysis+of+H%2B%2CK%28%2B%29-ATPase+using+in+vitro+translation.&rft.au=Bamberg%2C+K%3BSachs%2C+G&rft.aulast=Bamberg&rft.aufirst=K&rft.date=1994-06-17&rft.volume=269&rft.issue=24&rft.spage=16909&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-07-14 N1 - Date created - 1994-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic animal models of alcohol and drug abuse. AN - 76537135; 8209252 AB - Behavioral and pharmacological responses of selectively bred and inbred rodent lines have been analyzed to elucidate many features of drug sensitivity and the adverse effects of drugs, the underlying mechanisms of drug tolerance and dependence, and the motivational states underlying drug reward and aversion. Genetic mapping of quantitative trait loci (QTLs) has been used to identify provisional chromosomal locations of genes influencing such pharmacological responses. Recent advances in transgenic technology, representational difference analysis, and other molecular methods now make feasible the positional cloning of QTLs that influence sensitivity to drugs of abuse. This marks a new period of synthesis in pharmacogenetic research, in which networks of drug-related behaviors, their underlying pharmacological, physiological, and biochemical mechanisms, and particular genomic regions of interest are being identified. JF - Science (New York, N.Y.) AU - Crabbe, J C AU - Belknap, J K AU - Buck, K J AD - Research Service, Veterans Administration (VA) Medical Center, Portland, OR 97201. Y1 - 1994/06/17/ PY - 1994 DA - 1994 Jun 17 SP - 1715 EP - 1723 VL - 264 IS - 5166 SN - 0036-8075, 0036-8075 KW - Oligonucleotides, Antisense KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Reward KW - Genetic Techniques KW - Ethanol -- pharmacology KW - Oligonucleotides, Antisense -- pharmacology KW - Mice KW - Animals, Genetically Modified KW - Chromosome Mapping KW - Disease Models, Animal KW - Alcoholism -- genetics KW - Substance-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76537135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Genetic+animal+models+of+alcohol+and+drug+abuse.&rft.au=Crabbe%2C+J+C%3BBelknap%2C+J+K%3BBuck%2C+K+J&rft.aulast=Crabbe&rft.aufirst=J&rft.date=1994-06-17&rft.volume=264&rft.issue=5166&rft.spage=1715&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-07-12 N1 - Date created - 1994-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Striking a balance between safety and efficacy: experience with the SSRI sertraline. AN - 76816484; 7963450 AB - Depression is a widespread and serious disorder inflicting an immeasurable toll on the lives of millions of people and affecting their families and colleagues. It is the cause of countless suicides especially in those whose illness has not been detected or given appropriate care. Until recently, effective pharmacotherapeutic management of depression was hampered by the troublesome side effects associated with traditional methods of treatment. In an attempt to circumvent these adverse effects, many antidepressants were prescribed at less than therapeutic doses, resulting in a high probability of inadequate treatment, relapse, or recurrence. The development of the selective serotonin reuptake inhibitors (SSRIs) was guided by the need for an antidepressant that provided both safe and effective therapeutic benefit. Sertraline's potent and highly selective inhibition of serotonin accounts both for its efficacy in a broad spectrum of depression and for its high tolerability and ease of use. Its safety and tolerability have been demonstrated in acute and maintenance phases of treatment and establishes that sertraline provides a viable clinical alternative for acute and long-term care of depressed patients. JF - International clinical psychopharmacology AU - Casey, D E AD - Portland Oregon Veterans Administration Medical Center. Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 5 EP - 12 VL - 9 Suppl 3 SN - 0268-1315, 0268-1315 KW - Receptors, Serotonin KW - 0 KW - Serotonin Uptake Inhibitors KW - 1-Naphthylamine KW - 9753I242R5 KW - Sertraline KW - QUC7NX6WMB KW - Index Medicus KW - Receptors, Serotonin -- drug effects KW - Multicenter Studies as Topic KW - Cross-Sectional Studies KW - Randomized Controlled Trials as Topic KW - Humans KW - Brain -- drug effects KW - Adult KW - Treatment Outcome KW - Incidence KW - United States -- epidemiology KW - Depressive Disorder -- epidemiology KW - 1-Naphthylamine -- analogs & derivatives KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Depressive Disorder -- diagnosis KW - Depressive Disorder -- drug therapy KW - 1-Naphthylamine -- adverse effects KW - 1-Naphthylamine -- therapeutic use KW - Serotonin Uptake Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76816484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+clinical+psychopharmacology&rft.atitle=Striking+a+balance+between+safety+and+efficacy%3A+experience+with+the+SSRI+sertraline.&rft.au=Casey%2C+D+E&rft.aulast=Casey&rft.aufirst=D&rft.date=1994-06-01&rft.volume=9+Suppl+3&rft.issue=&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=International+clinical+psychopharmacology&rft.issn=02681315&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-12-07 N1 - Date created - 1994-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatic phosphatidylethanolamine methyltransferase activity is decreased by ethanol and increased by phosphatidylcholine. AN - 76777721; 7943660 AB - Phosphatidylethanolamine N-methyltransferase participates in the synthesis of membrane phosphatidylcholine. Its activity was reported to be decreased in patients with alcoholic cirrhosis, but it is not known whether this is a consequence of the cirrhosis or precedes it. This question was studied in a baboon model of alcohol-induced fibrosis. Phosphatidylethanolamine N-methyltransferase activity was measured in sequential percutaneous needle liver biopsies by the conversion of phosphatidylethanolamine to phosphatidylcholine, using radioactive S-adenosylmethionine as a methyl donor. Chronic alcohol consumption (1-6 years) significantly decreased hepatic phospholipid and phosphatidylcholine levels and reduced phosphatidyl-ethanolamine N-methyltransferase activity even before the development of fibrosis. These effects were prevented or attenuated by supplementing the diet with 2.8 g/1000 kcal of a preparation rich in dilinoleoyl phosphatidylcholine, a highly bioavailable phosphatidylcholine species. There were significant (p < 0.001) correlations between phosphatidylethanolamine N-methyltransferase activity and both hepatic phosphatidylcholine (r = 0.678) and total phospholipid (r = 0.662). 1. Alcohol consumption diminishes phosphatidylethanolamine N-methyltransferase activity prior to the development of cirrhosis and decreases the hepatic content of its product, namely phosphatidylcholine, a key component of cell membranes. This may promote hepatic injury and possibly trigger fibrosis. 2. Phosphatidylcholine administration ameliorates the ethanol-induced decrease in phosphatidylethanolamine N-methyltransferase activity and corrects phospholipid and phosphatidylcholine depletions, thereby possibly contributing to the protection against alcoholic liver injury. JF - Alcoholism, clinical and experimental research AU - Lieber, C S AU - Robins, S J AU - Leo, M A AD - Section of Liver Disease and Nutrition, Veterans Administration Medical Center, Bronx, NY 10468. Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 592 EP - 595 VL - 18 IS - 3 SN - 0145-6008, 0145-6008 KW - Membrane Lipids KW - 0 KW - Phosphatidylcholines KW - Phospholipids KW - Ethanol KW - 3K9958V90M KW - Methyltransferases KW - EC 2.1.1.- KW - Phosphatidylethanolamine N-Methyltransferase KW - EC 2.1.1.17 KW - Index Medicus KW - Papio KW - Animals KW - Phospholipids -- metabolism KW - Membrane Lipids -- metabolism KW - Biopsy KW - Male KW - Female KW - Liver -- pathology KW - Liver -- enzymology KW - Methyltransferases -- antagonists & inhibitors KW - Liver Cirrhosis, Alcoholic -- enzymology KW - Liver Cirrhosis, Alcoholic -- pathology KW - Phosphatidylcholines -- metabolism KW - Ethanol -- toxicity KW - Methyltransferases -- metabolism KW - Phosphatidylcholines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76777721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Hepatic+phosphatidylethanolamine+methyltransferase+activity+is+decreased+by+ethanol+and+increased+by+phosphatidylcholine.&rft.au=Lieber%2C+C+S%3BRobins%2C+S+J%3BLeo%2C+M+A&rft.aulast=Lieber&rft.aufirst=C&rft.date=1994-06-01&rft.volume=18&rft.issue=3&rft.spage=592&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-10-24 N1 - Date created - 1994-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of acute and chronic ethanol exposure on intestinal microvillus membrane lipid composition and fluidity. AN - 76775650; 7943655 AB - Chronic ethanol consumption produces nutrient malabsorption. The mechanisms by which this occurs are poorly understood. One potential mechanism is an alteration in microvillus membrane (MVM) composition and fluidity. The effects of in vivo ethanol exposure on MVM lipid composition and fluidity were determined in rats fed either a standard diet or 15% ethanol in water for 2 months. Acute jejunal exposure to 4% ethanol was also performed in vivo in each feeding group. Acute exposure to ethanol produced an increase in static and dynamic membrane fluidity associated with a decrease in MVM cholesterol regardless of prior ethanol exposure. Chronic ethanol feeding alone did not alter membrane fluidity. Changes in membrane fatty acid composition were minor and variable after both acute and chronic ethanol exposure. Prior chronic ethanol feeding did not prevent the acute effects of ethanol on MVM composition or fluidity. These data support the theory that ethanol acutely disrupts nutrient transport by changing MVM lipid fluidity. The absence of adaptive changes in membrane composition and fluidity may also explain the persistent absorptive defects seen with chronic alcoholism. JF - Alcoholism, clinical and experimental research AU - Bjorkman, D J AU - Jessop, L D AD - Division of Gastroenterology, Veterans Administration Medical Center, Salt Lake City, Utah. Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 560 EP - 565 VL - 18 IS - 3 SN - 0145-6008, 0145-6008 KW - Membrane Lipids KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Malabsorption Syndromes -- pathology KW - Intestinal Absorption -- physiology KW - Intestinal Absorption -- drug effects KW - Male KW - Alcoholic Intoxication -- pathology KW - Microvilli -- drug effects KW - Ethanol -- pharmacokinetics KW - Alcoholism -- pathology KW - Membrane Lipids -- metabolism KW - Membrane Fluidity -- drug effects KW - Intestinal Mucosa -- pathology KW - Intestinal Mucosa -- drug effects KW - Ethanol -- toxicity KW - Microvilli -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76775650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Effects+of+acute+and+chronic+ethanol+exposure+on+intestinal+microvillus+membrane+lipid+composition+and+fluidity.&rft.au=Bjorkman%2C+D+J%3BJessop%2C+L+D&rft.aulast=Bjorkman&rft.aufirst=D&rft.date=1994-06-01&rft.volume=18&rft.issue=3&rft.spage=560&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-10-24 N1 - Date created - 1994-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of clenbuterol on recovery of muscle mass and carcass protein content following experimental hyperthyroidism in old rats. AN - 76675607; 7914859 AB - The beta 2-adrenoceptor agonist, clenbuterol, has hastened the recovery of skeletal muscle and carcass weights and carcass protein stores lost during experimental hyperthyroidism in 24-month-old rats. Daily injection of 6.5 micrograms T3 per 100 g body weight for 2 weeks and 4.0 micrograms for the third week caused a 17-22% reduction in total body, carcass and combined hindlimb muscle weights, and a 16-21% reduction in carcass protein stores. Feeding diet containing 10 mg clenbuterol per kg during a 3-week recovery period caused complete restoration of these parameters to euthyroid control levels while the feeding control diet did not. JF - Comparative biochemistry and physiology. Comparative physiology AU - Carter, W J AU - Lynch, M E AD - Veterans Administration Medical Center, Little Rock, AR 72205. PY - 1994 SP - 387 EP - 394 VL - 108 IS - 2-3 KW - Proteins KW - 0 KW - Triiodothyronine KW - 06LU7C9H1V KW - Clenbuterol KW - XTZ6AXU7KN KW - Index Medicus KW - Rats KW - Hindlimb -- anatomy & histology KW - Eating -- drug effects KW - Animals KW - Rats, Inbred F344 KW - Triiodothyronine -- pharmacology KW - Body Weight -- drug effects KW - Hindlimb -- drug effects KW - Body Composition -- drug effects KW - Male KW - Organ Size -- drug effects KW - Muscles -- anatomy & histology KW - Clenbuterol -- pharmacology KW - Muscles -- metabolism KW - Hyperthyroidism -- metabolism KW - Diet KW - Proteins -- metabolism KW - Muscles -- drug effects KW - Hyperthyroidism -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76675607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comparative+biochemistry+and+physiology.+Comparative+physiology&rft.atitle=Effect+of+clenbuterol+on+recovery+of+muscle+mass+and+carcass+protein+content+following+experimental+hyperthyroidism+in+old+rats.&rft.au=Carter%2C+W+J%3BLynch%2C+M+E&rft.aulast=Carter&rft.aufirst=W&rft.date=1994-06-01&rft.volume=108&rft.issue=2-3&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Comparative+biochemistry+and+physiology.+Comparative+physiology&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-09-19 N1 - Date created - 1994-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Danger of corticosteroid administration in meningitis due to misdiagnosed agent. AN - 76667146; 8068165 AB - A 3 1/2-year-old child with acute tuberculous meningitis was misdiagnosed as having "partially treated" meningitis and was treated with ampicillin, chloramphenicol, and dexamethasone. She developed obstructive hydrocephalus and miliary spread of tuberculosis which led to death. It is likely that failure to consider alternative diagnoses promptly and the use of corticosteroids along with ineffective antibiotics contributed to the outcome. Although they may lessen some complications of bacterial meningitis, the indiscriminate use of corticosteroids in misdiagnosed bacterial meningitis may be detrimental. JF - Pediatric neurology AU - Davis, L E AD - Neurology Service, Veterans Administration Hospital, Albuquerque, New Mexico 87108. Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 338 EP - 339 VL - 10 IS - 4 SN - 0887-8994, 0887-8994 KW - Chloramphenicol KW - 66974FR9Q1 KW - Ampicillin KW - 7C782967RD KW - Dexamethasone KW - 7S5I7G3JQL KW - Index Medicus KW - Chloramphenicol -- therapeutic use KW - Meningitis, Bacterial -- diagnosis KW - Humans KW - Treatment Outcome KW - Drug Resistance, Microbial KW - Ampicillin -- therapeutic use KW - Mycobacterium tuberculosis -- drug effects KW - Diagnostic Errors KW - Meningitis, Bacterial -- drug therapy KW - Meningitis, Bacterial -- microbiology KW - Female KW - Child, Preschool KW - Dexamethasone -- therapeutic use KW - Dexamethasone -- adverse effects KW - Tuberculosis, Meningeal -- drug therapy KW - Tuberculosis, Meningeal -- microbiology KW - Tuberculosis, Meningeal -- diagnosis KW - Dexamethasone -- contraindications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76667146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+neurology&rft.atitle=Danger+of+corticosteroid+administration+in+meningitis+due+to+misdiagnosed+agent.&rft.au=Davis%2C+L+E&rft.aulast=Davis&rft.aufirst=L&rft.date=1994-06-01&rft.volume=10&rft.issue=4&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=Pediatric+neurology&rft.issn=08878994&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-09-23 N1 - Date created - 1994-09-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methods for the analysis of binary outcome results in the presence of missing data. AN - 76662333; 8063983 AB - An important, frequent, and unresolved problem in treatment research is deciding how to analyze outcome data when some of the data are missing. After a brief review of alternative procedures and the underlying models on which they are based, an approach is presented for dealing with the most common situation--comparing the outcome results in a 2-group, randomized design in the presence of missing data. The proposed analysis is based on the concept of "modeling our ignorance" by examining all possible outcomes, given a known number of missing results with a binary outcome, and then describing the distribution of those results. This method allows the researcher to define the range of all possible results that could have resulted had the missing data been observed. Extensions to more complex designs are discussed. JF - Journal of consulting and clinical psychology AU - Delucchi, K L AD - San Francisco Department of Veterans Administration Medical Center, California 94121. Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 569 EP - 575 VL - 62 IS - 3 SN - 0022-006X, 0022-006X KW - Index Medicus KW - Reproducibility of Results KW - Humans KW - Treatment Outcome KW - Patient Dropouts -- statistics & numerical data KW - Models, Statistical KW - Substance-Related Disorders -- rehabilitation KW - Bias (Epidemiology) KW - Psychology, Clinical -- statistics & numerical data KW - Randomized Controlled Trials as Topic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76662333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+consulting+and+clinical+psychology&rft.atitle=Methods+for+the+analysis+of+binary+outcome+results+in+the+presence+of+missing+data.&rft.au=Delucchi%2C+K+L&rft.aulast=Delucchi&rft.aufirst=K&rft.date=1994-06-01&rft.volume=62&rft.issue=3&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Journal+of+consulting+and+clinical+psychology&rft.issn=0022006X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-09-20 N1 - Date created - 1994-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pentoxifylline therapy for chronic claudication: are patients dependent on therapy? AN - 76518856; 8197567 AB - The purpose of this study was to evaluate the efficacy of long-term pentoxifylline therapy. Fifty consecutive patients on long-term pentoxifylline therapy entered a weaning program. The standard dose of 400 mg three times a day was reduced to 400 mg twice a day for 1 month, 400 mg daily for an additional month, and then withdrawn completely for 3 months. Subjective evaluation of each patient's symptoms and objective measurements (treadmill testing for initial claudication distance, maximum walking distance, and ankle/brachial indexes) were evaluated during treatment withdrawal. Twenty-seven patients tolerated withdrawal of therapy without symptomatic deterioration. Seven of nine patients who did not tolerate weaning had deterioration of treadmill ICD/MWD parameters; there was a significant absolute decrease (p = 0.016) in MWD from 430 +/- 78 to 221 +/- 23 feet. Patients with an initial low MWD were less likely to tolerate weaning. Sixty percent of the patients with successful weaning had clinically asymptomatic deterioration of treadmill ICD/MWD parameters. A substantial number of patients who have been on long-term successful pentoxifylline therapy for claudication can be weaned from the drug. Asymptomatic deterioration of treadmill test parameters is not an indication for resuming therapy. JF - Surgery AU - Johnson, W C AU - Watkins, M T AU - Hamilton, J AU - Baldwin, D AU - Walker, N AD - Department of Vascular Surgery, Boston Veterans Administration Medical Center Tufts University School of Medicine, Mass. Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 735 EP - 739 VL - 115 IS - 6 SN - 0039-6060, 0039-6060 KW - Pentoxifylline KW - SD6QCT3TSU KW - Abridged Index Medicus KW - Index Medicus KW - Exercise Test KW - Humans KW - Walking KW - Aged KW - Follow-Up Studies KW - Chronic Disease KW - Substance Withdrawal Syndrome KW - Pentoxifylline -- therapeutic use KW - Intermittent Claudication -- drug therapy KW - Pentoxifylline -- administration & dosage KW - Pentoxifylline -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76518856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Surgery&rft.atitle=Pentoxifylline+therapy+for+chronic+claudication%3A+are+patients+dependent+on+therapy%3F&rft.au=Johnson%2C+W+C%3BWatkins%2C+M+T%3BHamilton%2C+J%3BBaldwin%2C+D%3BWalker%2C+N&rft.aulast=Johnson&rft.aufirst=W&rft.date=1994-06-01&rft.volume=115&rft.issue=6&rft.spage=735&rft.isbn=&rft.btitle=&rft.title=Surgery&rft.issn=00396060&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-06-24 N1 - Date created - 1994-06-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dobutamine stress echocardiography: sensitivity, specificity, and predictive value for future cardiac events. AN - 76514123; 8197976 AB - We conducted a retrospective study to determine whether dobutamine stress echocardiography (DE) can be used for risk stratification of patients with known or suspected coronary artery disease (CAD). The study population consisted of 77 patients who underwent DE at our institution. The protocol consisted of an echocardiogram at baseline followed by imaging during intravenous dobutamine infusion starting at 10 micrograms/kg/min with increments of 10 micrograms/kg/min every 3 minutes to a maximum dose of 40 micrograms/kg/min. The reasons for performing DE included preoperative cardiac evaluation (30), chest pain (23), assessment of ischemia (18), and suspected restenosis (6). DE was classified according to wall motion response as normal (before and during DE), fixed abnormal (abnormal before with no change during DE), or ischemic (new wall-motion abnormality during DE). Mean duration of follow-up was 10 months. Cardiac events occurred in 14 patients. These included congestive heart failure in seven patients, myocardial infarction in six, and cardiac death in one. A normal wall-motion response (n = 40) was associated with a low incidence of cardiac events (5%), whereas 5 of 10 patients (50%) with an ischemic response had events. The risk of cardiac events was intermediate (26%) in patients with fixed abnormal wall motion. Overall sensitivity of DE for predicting future cardiac events was 85%. In 45 patients who underwent coronary angiography within 2 months of DE, the test detected CAD with a sensitivity of 71%. In conclusion, the wall-motion response during DE may be used for identifying patients at high risk for future cardiac events. JF - American heart journal AU - Afridi, I AU - Quiñones, M A AU - Zoghbi, W A AU - Cheirif, J AD - Department of Internal Medicine, Baylor College of Medicine, Veterans Administration Hospital, Houston, Texas. Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 1510 EP - 1515 VL - 127 IS - 6 SN - 0002-8703, 0002-8703 KW - Dobutamine KW - 3S12J47372 KW - Abridged Index Medicus KW - Index Medicus KW - Sensitivity and Specificity KW - Texas -- epidemiology KW - Coronary Angiography KW - Humans KW - Retrospective Studies KW - Aged KW - Predictive Value of Tests KW - Evaluation Studies as Topic KW - Confidence Intervals KW - Coronary Disease -- epidemiology KW - Incidence KW - Follow-Up Studies KW - Middle Aged KW - Coronary Disease -- diagnostic imaging KW - Male KW - Proportional Hazards Models KW - Echocardiography -- instrumentation KW - Echocardiography -- methods KW - Echocardiography -- statistics & numerical data KW - Dobutamine -- adverse effects KW - Exercise Test -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76514123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=Dobutamine+stress+echocardiography%3A+sensitivity%2C+specificity%2C+and+predictive+value+for+future+cardiac+events.&rft.au=Afridi%2C+I%3BQui%C3%B1ones%2C+M+A%3BZoghbi%2C+W+A%3BCheirif%2C+J&rft.aulast=Afridi&rft.aufirst=I&rft.date=1994-06-01&rft.volume=127&rft.issue=6&rft.spage=1510&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=00028703&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-06-29 N1 - Date created - 1994-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quality of Care in Public and Private Primary Health Care Facilities: Structural Comparisons in Jamaica AN - 61591991; 199503275 AB - Examines the types of health care provided by 366 public & 189 private primary care clinics in Jamaica. Findings of 1990 surveys & site visits (N = 555) indicate that public clinics provide better prenatal diagnosis & counseling, as well as more family planning services, than private clinics, while the latter tend to be in better condition, better equipped & supplied, & better able to provide timely lab tests. Urban clinics are better equipped & supplied, while rural clinics are typically in better repair. It is hoped that policymakers will use these findings to guide concrete interventions, since they summarize the structural elements of health care quality at different types of facilities & provide a less costly analysis of programs designed to improve primary health care services. 4 Tables, 7 Figures, 18 References. Adapted from the source document. JF - Bulletin of the Pan American Health Organization AU - Peabody, John W AU - Rahman, Omar AU - Fox, Kristin AU - Gertler, Paul AD - Veterans' Administration Hospital, West Los Angeles CA 90073-1002 Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 122 EP - 141 VL - 28 IS - 2 SN - 0085-4638, 0085-4638 KW - health care quality, public vs private clinics, Jamaica KW - 1990 survey/site visit data KW - Public Sector Private Sector Relations KW - Quality of Health Care KW - Primary Health Care KW - Clinics KW - Jamaica KW - article KW - 6140: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61591991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+the+Pan+American+Health+Organization&rft.atitle=Quality+of+Care+in+Public+and+Private+Primary+Health+Care+Facilities%3A+Structural+Comparisons+in+Jamaica&rft.au=Peabody%2C+John+W%3BRahman%2C+Omar%3BFox%2C+Kristin%3BGertler%2C+Paul&rft.aulast=Peabody&rft.aufirst=John&rft.date=1994-06-01&rft.volume=28&rft.issue=2&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+the+Pan+American+Health+Organization&rft.issn=00854638&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Quality of Health Care; Public Sector Private Sector Relations; Clinics; Jamaica; Primary Health Care ER - TY - JOUR T1 - Flight Simulator Performance of Older Aircraft Pilots: Effects of Age and Alcohol AN - 61372918; 9501639 AB - A comparative group study examined the effects of alcohol vs placebo in younger (N = 14 ages 21-34) & older (N = 13 ages 51-69) pilots at the time of acute intoxication (blood alcohol level at 0.10%) & 8 hours later. Ss completed a simulator flight task that they had not practiced in the previous 10 months. Alcohol had detrimental effects on performance at both times for both age groups. There was no significant difference between the performances of the younger & older age groups at either time. It is concluded that an 8-hour waiting period between drinking & flying is insufficient & that age differences in recollection of a previously learned task & in susceptibility to alcohol & alcohol hangover are negligible. 3 Tables, 1 Figure, 23 References. Adapted from the source document. JF - Journal of the American Geriatrics Society AU - Yesavage, Jerome A AU - Dolhert, Nancy AU - Taylor, Joy L AD - Psychiatry Service (151Y) Veterans Administration Medical Center, 3801 Miranda Ave Palo Alto CA 94304 Y1 - 1994/06// PY - 1994 DA - June 1994 SP - 577 EP - 582 VL - 42 IS - 6 SN - 0002-8614, 0002-8614 KW - flight performance, older vs younger pilots KW - alcohol KW - simulation data KW - Air Transportation KW - Alcohol Use KW - Job Performance KW - Age Differences KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61372918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Flight+Simulator+Performance+of+Older+Aircraft+Pilots%3A+Effects+of+Age+and+Alcohol&rft.au=Yesavage%2C+Jerome+A%3BDolhert%2C+Nancy%3BTaylor%2C+Joy+L&rft.aulast=Yesavage&rft.aufirst=Jerome&rft.date=1994-06-01&rft.volume=42&rft.issue=6&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JAGSAF N1 - SubjectsTermNotLitGenreText - Job Performance; Age Differences; Alcohol Use; Air Transportation ER - TY - JOUR T1 - Muscle Functional Deficits After Tourniquet Ischemia AN - 20077703; 10094195 AB - The contractile properties of the rabbit tibialis anterior muscle were studied 48 hours after an ischemic episode induced by pneumatic tourniquet compression of the thigh. Forty animals were divided into five groups, each of which had continuous ischemia of either 1, 2, or 4 hours, or a total of 2 or 4 hours of ischemia interrupted by 10 minutes of reperfusion at 1-hour intervals. Con tralateral limbs served as controls. Muscle contractile properties were tested by stimulation of the peroneal nerve distal to the site of tourniquet compression. Peak tetanic tension in the 1-hour group did not differ signifi cantly from controls. In the 2- and 4-hour groups, peak tetanic tensions were 31 % and 2% of controls, respec tively, and twitch tensions were 25% and 1 % of controls, respectively. Hourly reperfusion intervals had no sig nificant effect on maximum tetanic or twitch tension compared with continuous ischemia for either 2 or 4 hours.Clinically significant muscle dysfunction may be in duced by 2 or more hours of pneumatic tourniquet ap plication. Hourly reperfusion intervals may not improve skeletal muscle function distal to the tourniquet. How ever, reperfusion intervals could still affect muscle that is compressed beneath the cuff. Tourniquet-induced contractile deficits may interfere with postoperative functional recovery. JF - American Journal of Sports Medicine AU - Jacobson, Mark D AU - Pedowitz, Robert A AU - Oyama, Brian K AU - Tryon, Brian AU - Gershuni, David H AD - Department of Orthopaedic Surgery, Veterans Administration Medical Center, and the University of California, San Diego, California Y1 - 1994/06// PY - 1994 DA - Jun 1994 SP - 372 EP - 377 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 22 IS - 3 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - Muscles (function) KW - Blood flow KW - Recovery KW - Animal subjects KW - Muscles KW - Stimuli KW - Legs KW - Sports medicine KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20077703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Sports+Medicine&rft.atitle=Muscle+Functional+Deficits+After+Tourniquet+Ischemia&rft.au=Jacobson%2C+Mark+D%3BPedowitz%2C+Robert+A%3BOyama%2C+Brian+K%3BTryon%2C+Brian%3BGershuni%2C+David+H&rft.aulast=Jacobson&rft.aufirst=Mark&rft.date=1994-06-01&rft.volume=22&rft.issue=3&rft.spage=372&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Sports+Medicine&rft.issn=03635465&rft_id=info:doi/10.1177%2F036354659402200313 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Muscles (function); Recovery; Blood flow; Animal subjects; Muscles; Stimuli; Legs; Sports medicine DO - http://dx.doi.org/10.1177/036354659402200313 ER - TY - JOUR T1 - Computer simulations of the effects of different synaptic input systems on the steady-state input-output structure of the motoneuron pool. AN - 85241423; pmid-7914915 AB - 1. The effects of different types of synaptic input on the steady-state input-output relations of the mammalian motoneuron pool were investigated by the use of computer simulations. The properties of the simulated motor units and their synaptic inputs were based as closely as possible on the experimental data from studies in the cat hindlimb. 2. Three basic types of synaptic input systems were simulated: postsynaptic, presynaptic, and neuromodulatory. The effects of these inputs on three aspects of the system input-output structure were studied: gain, precision, and motor-unit type utilization. 3. The gain analyses were based on a simulation of the steady-state homonymous Ia input. The gain of this steady-state Ia "reflex" was found to be determined largely by the slope of the pool input-output function. Precision was evaluated in two ways, from the amplitudes of the quantal steps due to motor-unit recruitment and from the sensitivity of the input-output function to noise. The pattern of motor-unit type utilization allowed indirect assessment of fatigue resistance: the larger the percentage of force generated by FF units, the lower the fatigue resistance. 4. A uniformly distributed input (i.e., one that generates equal input in all motoneurons) generates outputs that are solely determined by the intrinsic properties of the motor units. Thus the gain, precision, and motor-unit type patterns generated by a uniform input were used as the basis with which the effects of all other input systems were compared. 5. Postsynaptic excitatory inputs with nonuniform distributions within the pool did influence gain. The greatest effect was the increase mediated by the rubrospinal excitatory input (27% increase at 30% of maximal force). However, this input also greatly decreased both fatigue resistance and precision, due to increased activation of FF units at low force levels. In contrast, the Ia input slightly decreased gain (12% decrease at 30% of maximum force) while slightly increasing fatigue resistance and precision. 6. The simulated neuromodulatory input was based on the monoaminergic reticulospinal effect on motoneurons. Gain was generally increased by the monoaminergic input. However, the magnitude of the increase strongly depended on whether the monoaminergic effects were largest on S units (giving a 20% increase at 30% of maximum force), equal on all types (52%), or largest on FF units (102%). Presynaptic inhibition reduced gain with no effect whatsoever on fatigue resistance or precision. 7. Therefore Ia reflex gain was modifiable by all three types of input: postsynaptic, presynaptic, and neuromodulatory.(ABSTRACT TRUNCATED AT 400 WORDS) JF - Journal of Neurophysiology AU - Heckman, C J AD - Veterans Administration, Lakeside Hospital, Chicago, Illinois. PY - 1994 SP - 1727 EP - 1739 VL - 71 IS - 5 SN - 0022-3077, 0022-3077 KW - Support, U.S. Gov't, P.H.S. KW - Hindlimb KW - Cats KW - Muscles KW - Animal KW - Membrane Potentials KW - Support, U.S. Gov't, Non-P.H.S. KW - Reflex, Stretch KW - Neurotransmitters KW - Muscle Contraction KW - Neural Inhibition KW - Recruitment (Neurology) KW - Synaptic Transmission KW - Motor Neurons KW - Computer Simulation KW - Models, Neurological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85241423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurophysiology&rft.atitle=Computer+simulations+of+the+effects+of+different+synaptic+input+systems+on+the+steady-state+input-output+structure+of+the+motoneuron+pool.&rft.au=Heckman%2C+C+J&rft.aulast=Heckman&rft.aufirst=C&rft.date=1994-05-01&rft.volume=71&rft.issue=5&rft.spage=1727&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurophysiology&rft.issn=00223077&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Is there a correlation between serum antifungal drug concentration and clinical outcome? AN - 76692010; 8077687 AB - Effective broad spectrum antifungal therapy has been available since the introduction of amphotericin B three decades ago. Amphotericin B must be given intravenously, and thus access to the bloodstream is assured. Because of the great toxicity of this agent, initial studies were directed at determining a dose which was tolerable and clinically effective. In part because of few data and in part because of major concerns with toxicity, there is at present no established relationship with amphotericin B serum concentrations and clinical outcome, and there is no clear indication for measurement of serum concentrations of this drug. More recently there has appeared a variety of orally administered antifungal azole derivatives. Oral absorption is affected by a variety of factors, and drug access to the blood stream is not readily predictable for some of these drugs. Serum concentrations have not been consistently assessed in clinical studies. Where they have been measured, there does appear to be a loose correlation of clinical response with the detection of some amount of drug in the bloodstream. However, beyond this 'threshold' concentration, there is no compelling evidence for a correlation of serum concentration and clinical outcome. While serum concentration of azoles may be useful in determining absorption of drug, at present there is no impetus for achieving a given concentration in the blood to improve chances of a good outcome. JF - The Journal of infection AU - Graybill, J R AD - Veterans Administration Hospital, San Antonio, TX 78284. Y1 - 1994/05// PY - 1994 DA - May 1994 SP - 17 EP - 24 VL - 28 Suppl 1 SN - 0163-4453, 0163-4453 KW - Antifungal Agents KW - 0 KW - Piperazines KW - Itraconazole KW - 304NUG5GF4 KW - Amphotericin B KW - 7XU7A7DROE KW - Ketoconazole KW - R9400W927I KW - Index Medicus KW - Administration, Oral KW - Amphotericin B -- blood KW - Injections, Intravenous KW - Humans KW - Amphotericin B -- pharmacokinetics KW - Amphotericin B -- administration & dosage KW - Liver -- metabolism KW - Ketoconazole -- pharmacokinetics KW - Piperazines -- pharmacokinetics KW - Itraconazole -- pharmacokinetics KW - Risk Factors KW - Treatment Outcome KW - Amphotericin B -- adverse effects KW - Microbial Sensitivity Tests KW - Mycoses -- drug therapy KW - Antifungal Agents -- blood KW - Mycoses -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76692010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infection&rft.atitle=Is+there+a+correlation+between+serum+antifungal+drug+concentration+and+clinical+outcome%3F&rft.au=Graybill%2C+J+R&rft.aulast=Graybill&rft.aufirst=J&rft.date=1994-05-01&rft.volume=28+Suppl+1&rft.issue=&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infection&rft.issn=01634453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-10-06 N1 - Date created - 1994-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synergistic increases in rat hepatic cytochrome P450s by ethanol and isopentanol. AN - 76483213; 8182553 AB - The purpose of this study was to determine if isopentanol alone or in combination with ethanol increased CYP2B1/2, CYP2E or CYP3A in the livers of rats. Increasing doses of isopentanol (0.5, 1, 2 or 3%) were administered in combination with 5.6% ethanol in the Lieber-DeCarli liquid diet for 7 days. Doses of 0.5 or 3% isopentanol were also administered alone. Isopentanol alone caused small increases in CYP2B1/2 and CYP3A. However, when isopentanol (2 or 3%) was combined with ethanol a synergistic increase in P4502B1/2 was observed. The combined alcohol treatment also resulted in a greater increase in immunoreactive CYP3A than either alcohol alone. Ethanol alone increased CYP2E 5-fold. Inclusion of isopentanol with ethanol resulted in either small or no additional increases in CYP2E. These results confirm our previous findings in cultured hepatocytes that when isopentanol is combined with ethanol, there is a synergistic increase in CYP2B1/2. Increases in CYP2B1/2, CYP2E and CYP3A protein moieties by ethanol, and by ethanol in combination with isopentanol, were associated with increases in their mRNAs. Blood isopentanol levels were 10-fold greater in rats administered 3% isopentanol in combination with ethanol compared to rats administered 3% isopentanol alone. From these results we suggest that isopentanol, a higher chain alcohol in alcoholic beverages, can contribute to increases in hepatic cytochrome P450 observed following consumption of alcoholic beverages. JF - The Journal of pharmacology and experimental therapeutics AU - Louis, C A AU - Wood, S G AU - Kostrubsky, V AU - Sinclair, P R AU - Sinclair, J F AD - Veterans Administration Medical Center, White River Junction, Vermont. Y1 - 1994/05// PY - 1994 DA - May 1994 SP - 838 EP - 845 VL - 269 IS - 2 SN - 0022-3565, 0022-3565 KW - Pentanols KW - 0 KW - RNA, Messenger KW - Ethanol KW - 3K9958V90M KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - isopentyl alcohol KW - DEM9NIT1J4 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Base Sequence KW - RNA, Messenger -- metabolism KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Enzyme Activation KW - RNA, Messenger -- drug effects KW - Molecular Sequence Data KW - Drug Synergism KW - Male KW - Pentanols -- pharmacology KW - Ethanol -- blood KW - Liver -- enzymology KW - Liver -- drug effects KW - Ethanol -- pharmacology KW - Cytochrome P-450 Enzyme System -- genetics KW - Cytochrome P-450 Enzyme System -- metabolism KW - Pentanols -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76483213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Synergistic+increases+in+rat+hepatic+cytochrome+P450s+by+ethanol+and+isopentanol.&rft.au=Louis%2C+C+A%3BWood%2C+S+G%3BKostrubsky%2C+V%3BSinclair%2C+P+R%3BSinclair%2C+J+F&rft.aulast=Louis&rft.aufirst=C&rft.date=1994-05-01&rft.volume=269&rft.issue=2&rft.spage=838&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-06-16 N1 - Date created - 1994-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk Factors for AMA Discharge from VA Inpatient Alcoholism Treatment Programs AN - 61582790; 199500909 AB - A review of the medical records for 186 male alcoholics who were discharged AMA (against medical advice) & 201 who completed treatment at a Veterans Administration hospital are used to explore risk factors associated with AMA discharge & underlying reasons for these discharges. Analysis indicates that comorbid medical diagnosis reduced the risk of AMA discharge by 25%, whereas court referral to treatment reduced the risk by 50%. A college education, vocational or other training, being employed, & having a history of previous AMA discharges significantly increased the risk. The most common reasons for AMA discharge, as perceived by treatment providers, were psychosocial problems, difficulties in the treatment program, & lack of interest in treatment. The clinical implications of these findings for the inpatient treatment of alcoholics are discussed. 5 Tables, 22 References. Adapted from the source document. JF - Journal of Substance Abuse Treatment AU - Cook, Cynthia A. Loveland AU - Booth, Brenda M AU - Blow, Frederic C AU - McAleenan, Kathleen A AU - Bunn, Janice Y AD - Health Services Research & Development Veterans Administration Medical Center, 1481 West 10th St Indianapolis IN 46202 Y1 - 1994/05// PY - 1994 DA - May 1994 SP - 239 EP - 245 VL - 11 IS - 3 SN - 0740-5472, 0740-5472 KW - against-medical-advice discharges, risk factors, Veterans Administration alcoholism treatment programs KW - medical record data KW - Veterans KW - Discharge KW - Risk KW - Males KW - Alcoholism KW - Termination of Treatment KW - Patients KW - Medical Decision Making KW - article KW - 6129: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61582790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Risk+Factors+for+AMA+Discharge+from+VA+Inpatient+Alcoholism+Treatment+Programs&rft.au=Cook%2C+Cynthia+A.+Loveland%3BBooth%2C+Brenda+M%3BBlow%2C+Frederic+C%3BMcAleenan%2C+Kathleen+A%3BBunn%2C+Janice+Y&rft.aulast=Cook&rft.aufirst=Cynthia+A.&rft.date=1994-05-01&rft.volume=11&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Medical Decision Making; Patients; Alcoholism; Discharge; Termination of Treatment; Risk; Veterans; Males ER - TY - JOUR T1 - Lipoprotein lipase domain function. AN - 76424230; 8144612 AB - Human lipoprotein lipase (LPL) monomer consists of two domains, a larger NH2-terminal domain that contains catalytic residues and a smaller COOH-terminal domain that modulates substrate specificity and is a major determinant of heparin binding. Analyses of NH2-terminal domain function were performed after site-directed mutagenesis of the putative active-site serine residue, while COOH-terminal domain function was assessed following reaction with a monoclonal antibody. The native enzyme and mutant LPL in which serine 132 was replaced with alanine, cysteine, or glycine were transiently expressed in COS-7 cells. Mutant proteins were synthesized and secreted at levels comparable to native LPL; however, none of the mutants retained enzymatic activity. The mutant with alanine replacing serine 132 was purified and shown to be inactive with both esterase and lipase substrates; however, binding to a 1,2-didodecanoyl-sn-glycero-3-phosphatidylcholine monolayer was comparable to native LPL. These results are consistent with a catalytic, and not a lipid binding, role for serine 132. To investigate the function of the smaller COOH-terminal domain, LPL lipolytic and esterolytic activities as well as heparin binding properties were determined after reaction with a monoclonal antibody specific for this domain. Lipolytic activity was inhibited by the monoclonal antibody, whereas esterolytic activity was only marginally affected, indicating that the LPL COOH-terminal domain is required for lipolysis, perhaps by promoting interaction with insoluble substrates. Also, the affinity of antibody-reacted LPL for heparin was not significantly different from that of LPL alone, suggesting that (i) the heparin-binding site is physically distinct from the COOH-terminal domain region required for lipolysis and (ii) binding of antibody did not cause dimer dissociation. A model is proposed for the two LPL domains fulfilling different roles in the lipolytic process. JF - The Journal of biological chemistry AU - Wong, H AU - Davis, R C AU - Thuren, T AU - Goers, J W AU - Nikazy, J AU - Waite, M AU - Schotz, M C AD - Lipid Research Laboratory, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073. Y1 - 1994/04/08/ PY - 1994 DA - 1994 Apr 08 SP - 10319 EP - 10323 VL - 269 IS - 14 SN - 0021-9258, 0021-9258 KW - DNA, Complementary KW - 0 KW - Serine KW - 452VLY9402 KW - Heparin KW - 9005-49-6 KW - Lipoprotein Lipase KW - EC 3.1.1.34 KW - Index Medicus KW - Animals KW - Cattle KW - Cells, Cultured KW - Humans KW - Heparin -- metabolism KW - Substrate Specificity KW - Mutation KW - Serine -- metabolism KW - Binding Sites KW - Lipoprotein Lipase -- metabolism KW - Lipoprotein Lipase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76424230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Lipoprotein+lipase+domain+function.&rft.au=Wong%2C+H%3BDavis%2C+R+C%3BThuren%2C+T%3BGoers%2C+J+W%3BNikazy%2C+J%3BWaite%2C+M%3BSchotz%2C+M+C&rft.aulast=Wong&rft.aufirst=H&rft.date=1994-04-08&rft.volume=269&rft.issue=14&rft.spage=10319&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-05-05 N1 - Date created - 1994-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Can you trust patient self-reports of drug use during treatment? AN - 76629968; 8055734 AB - This study compared two frequently used measures of drug use, urine testing and self-report in a sample of subjects currently enrolled in methadone treatment for a minimum of six months. A comparison between the percentage of positive opiate urine screens and subjects' self-reported opiate use indicated that more patients self-reported opiate use (80%) than had been detected by urinalysis (57%). Similar results were found for cocaine use. We present arguments that a more inclusive method of measuring drug use during treatment should include the combination of both urinalysis and self-reports. JF - Drug and alcohol dependence AU - Zanis, D A AU - McLellan, A T AU - Randall, M AD - Penn-VA Center for Studies of Addiction, Philadelphia Veterans Administration Medical Center 19104. Y1 - 1994/04// PY - 1994 DA - April 1994 SP - 127 EP - 132 VL - 35 IS - 2 SN - 0376-8716, 0376-8716 KW - Narcotics KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Humans KW - Adult KW - Treatment Outcome KW - Retrospective Studies KW - Narcotics -- pharmacokinetics KW - Middle Aged KW - Follow-Up Studies KW - Cocaine -- pharmacokinetics KW - Personality Assessment KW - Male KW - Female KW - Methadone -- therapeutic use KW - Opioid-Related Disorders -- psychology KW - Substance Abuse Detection -- psychology KW - Opioid-Related Disorders -- rehabilitation KW - Truth Disclosure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76629968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Can+you+trust+patient+self-reports+of+drug+use+during+treatment%3F&rft.au=Zanis%2C+D+A%3BMcLellan%2C+A+T%3BRandall%2C+M&rft.aulast=Zanis&rft.aufirst=D&rft.date=1994-04-01&rft.volume=35&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-09-12 N1 - Date created - 1994-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationship between treatment length and outcome in a therapeutic community. AN - 76590670; 8034382 AB - The present study examines the association between treatment length and treatment outcome among drug users treated in a therapeutic community. The therapeutic community employed in the present study recently had been changed from a 6-month to a 1-month program by external administrative mandate, but had undergone virtually no other changes. Twenty-two subjects who received 6 months of treatment and 22 who received 1 month were compared. The 6-month group had more subjects with successful outcome. These results support previous studies associating longer treatment programs with better outcome. JF - The International journal of the addictions AU - Bleiberg, J L AU - Devlin, P AU - Croan, J AU - Briscoe, R AD - Veterans Administration Medical Center, Washington, D.C. Y1 - 1994/04// PY - 1994 DA - April 1994 SP - 729 EP - 740 VL - 29 IS - 6 SN - 0020-773X, 0020-773X KW - Index Medicus KW - Severity of Illness Index KW - Substance Abuse Treatment Centers KW - Risk Factors KW - Humans KW - Adult KW - Treatment Outcome KW - African Americans KW - Male KW - Substance-Related Disorders -- therapy KW - Length of Stay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76590670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+the+addictions&rft.atitle=Relationship+between+treatment+length+and+outcome+in+a+therapeutic+community.&rft.au=Bleiberg%2C+J+L%3BDevlin%2C+P%3BCroan%2C+J%3BBriscoe%2C+R&rft.aulast=Bleiberg&rft.aufirst=J&rft.date=1994-04-01&rft.volume=29&rft.issue=6&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+the+addictions&rft.issn=0020773X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-08-18 N1 - Date created - 1994-08-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Partial versus total portacaval shunt in alcoholic cirrhosis. Results of a prospective, randomized clinical trial. AN - 76445619; 8161260 AB - Results of the first prospective randomized clinical trial comparing partial and total portacaval shunt for variceal hemorrhage are reported. Total portacaval shunts produce subnormal portal pressures, completely diverting hepatic portal flow. Partial shunts maintain higher pressures and preserve hepatopedal flow. No randomized trials of these two approaches have been performed. Alcoholic patients with cirrhosis (n = 30) and variceal hemorrhage treated at one institution were randomized to receive partial (8-mm diameter portacaval H grafts with collateral ablation, n = 14) or total shunts (16-mm diameter grafts, n = 16). Portography was performed after operation and then yearly. Investigators blinded to shunt type assessed encephalopathy; hospitalizations were reviewed. Child's class, age, and operative urgency were similar for the two groups. Two patients (with total shunts) died within 30 days. Hepatopedal flow was maintained in 13 partial and 0 total shunt patients (p < 0.0001). Shunt gradients were 16 +/- 5 compared with 6 +/- 3 cm saline after partial and total shunts (p < 0.0001). There were no shunt thromboses or variceal hemorrhages. Encephalopathy-free survival was significantly greater after partial shunts (p = 0.013; life table analysis). Five total compared with zero partial shunt patients required hospitalization for coma (p = 0.02). Long-term survival was not different for the two groups of patients. Partial shunts control variceal hemorrhage while maintaining hepatopedal flow and elevated portal pressures. By minimizing encephalopathy rates, partial shunts provide improved quality of survival compared with total shunts. JF - Annals of surgery AU - Sarfeh, I J AU - Rypins, E B AD - Surgical Service, Long Beach Veterans Administration Medical Center, California. Y1 - 1994/04// PY - 1994 DA - April 1994 SP - 353 EP - 361 VL - 219 IS - 4 SN - 0003-4932, 0003-4932 KW - Abridged Index Medicus KW - Index Medicus KW - Prospective Studies KW - Postoperative Complications KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Liver Cirrhosis, Alcoholic -- complications KW - Hemorrhage -- complications KW - Liver Cirrhosis, Alcoholic -- surgery KW - Hypertension, Portal -- complications KW - Hypertension, Portal -- surgery KW - Portacaval Shunt, Surgical -- methods KW - Hemorrhage -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76445619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+surgery&rft.atitle=Partial+versus+total+portacaval+shunt+in+alcoholic+cirrhosis.+Results+of+a+prospective%2C+randomized+clinical+trial.&rft.au=Sarfeh%2C+I+J%3BRypins%2C+E+B&rft.aulast=Sarfeh&rft.aufirst=I&rft.date=1994-04-01&rft.volume=219&rft.issue=4&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Annals+of+surgery&rft.issn=00034932&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-05-17 N1 - Date created - 1994-05-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Surg. 1967 Sep;166(3):437-55 [6068492] Am J Surg. 1993 May;165(5):566-71 [8488938] Am J Surg. 1978 Apr;135(4):584-8 [147633] Am J Surg. 1980 Jan;139(1):132-41 [7350837] Ann Surg. 1983 Apr;197(4):422-6 [6600914] Surgery. 1983 Aug;94(2):126-33 [6879434] Ann Surg. 1983 Sep;198(3):325-34 [6615055] J Surg Res. 1984 Aug;37(2):119-22 [6748631] Clin Gastroenterol. 1985 Jan;14(1):259-88 [3886215] Ann Surg. 1985 Jun;201(6):712-22 [3890781] J Hepatol. 1985;1(6):649-61 [4056359] Surgery. 1986 Jul;100(1):52-8 [3726761] Ann Surg. 1986 Oct;204(4):356-63 [3490229] Am J Surg. 1987 Jan;153(1):80-5 [3799896] Am J Surg. 1988 Jan;155(1):152-8 [3341529] Am J Surg. 1991 Jan;161(1):159-63; discussion 163-4 [1987851] Ann Intern Med. 1992 Feb 15;116(4):304-9 [1733385] Gastroenterol Clin North Am. 1992 Mar;21(1):197-213 [1568773] Surgery. 1992 Jun;111(6):610-6 [1595057] Am J Surg. 1992 Sep;164(3):225-7; discussion 227-8 [1415919] Am J Surg. 1993 Jan;165(1):27-32; discussion 32-3 [8418700] Hepatology. 1993 Jan;17(1):148-58 [8423036] Ann Surg. 1974 Feb;179(2):209-18 [4544047] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multiple-Stimulus Method for Rapid Collection of Auditory Brainstem Responses Using High-Frequency ((greater than or equal to) 8 kHz) Tone Bursts AN - 85575205; 9409330 AB - To meet the need for a reliable objective monitoring tool that will give the earliest possible warning of auditory damage caused by treatment with ototoxic agents, a multiple-stimulus method for evoking auditory brainstem response (ABR) with several high-frequency tone-burst stimuli is developed. A study (N = 10 normal-hearing adults) was performed where 4 high-frequency tone-burst stimuli were presented singly, then in a multiple-stimulus sequence with onsets separated by 10 msec. Wave V response latencies from the multiple-stimulus sequences are compared to those presented singly, with small but statistically significant longer latencies observed for all stimuli following the initial stimulus in the multiple sequence. Reliability of the multiple-stimulus sequencing technique is demonstrated here, as is the rapidity of test administration. Results strongly suggest that the multiple, high-frequency stimulus technique has significant potential for monitoring Ss receiving ototoxic agents for the purpose of early detection of hearing change. 4 Tables, 4 Figures, 44 References. Adapted from the source document JF - Journal of the American Academy of Audiology AU - Fausti, Stephen A AU - Mitchell, Curtin R AU - Frey, Richard H AU - Henry, James A AU - O'Connor, Jody L AD - Portland Veterans Administration Medical Center, PO Box 1034 [151J] OR 97207 Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 119 EP - 126 VL - 5 IS - 2 SN - 1050-0545, 1050-0545 KW - auditory brainstem response collection, high-frequency tone burst use KW - experiments KW - normal-hearing adults KW - Audiometry (05600) KW - Evoked Responses (23450) KW - Adults (00600) KW - article KW - 6311: hearing-pathological and normal; auditory perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85575205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Multiple-Stimulus+Method+for+Rapid+Collection+of+Auditory+Brainstem+Responses+Using+High-Frequency+%28%28greater+than+or+equal+to%29+8+kHz%29+Tone+Bursts&rft.au=Fausti%2C+Stephen+A%3BMitchell%2C+Curtin+R%3BFrey%2C+Richard+H%3BHenry%2C+James+A%3BO%27Connor%2C+Jody+L&rft.aulast=Fausti&rft.aufirst=Stephen&rft.date=1994-03-01&rft.volume=5&rft.issue=2&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JAAAE3 N1 - SubjectsTermNotLitGenreText - Evoked Responses (23450); Audiometry (05600); Adults (00600) ER - TY - JOUR T1 - Ursodeoxycholic therapy in chronic liver disease: a meta-analysis in primary biliary cirrhosis and in chronic hepatitis. AN - 85226297; pmid-8122652 AB - OBJECTIVES: to determine whether ursodeoxycholic acid (UDCA) is effective in improving primary biliary cirrhosis (PBC) or chronic hepatitis (CH). METHODS: Meta-analysis (MA) was performed on nine papers and three abstracts describing PBC and on nine papers and two abstracts with CH that were published between 1985 and 1992 and were identified through MEDLINE. Studies were included if they fulfilled established quality criteria and the patients had at least liver histology at the start and two to three relevant laboratory tests repeated after UDCA. A total of 800 patients with PBC were treated for 6-48 months. In CH, 285 patients were treated for 1-21 months. RESULTS: In PBC, an average daily UDCA of 13 mg/kg.day improved the liver tests AST, ALT, ALP, and GGT (all p < 0.001). The effect on serum bilirubin was too heterogeneous to evaluate. When evaluated individually, the studies showed an indeterminate effect on histologic progression and treatment failure. When pooled in MA, UDCA improved the liver histology (p < 0.001) and prevented treatment failure (p < 0.04). In CH, UDCA at an average of 11 mg/kg.day improved AST, ALT, GGT, and total bilirubin (all p < 0.001) and also ALP (p = 0.014). There was no effect on histology of CH and no data on treatment failure. CONCLUSIONS: MA confirmed a beneficial effect of UDCA in PBC on liver tests, histology, and treatment failure. In CH, there was an improvement in liver tests, but the evidence for histologic effect was sparse and insignificant. Future studies in PBC must explore the disease after UDCA is discontinued. Trials in CH should distinguish between the diagnostic subgroups, document patient compliance with UDCA, and include histology and treatment failure as end points. JF - The American Journal of Gastroenterology AU - Simko, V AU - Michael, S AU - Prego, V AD - Section of Gastroenterology, Brooklyn Veterans Administration Medical Center. PY - 1994 SP - 392 EP - 398 VL - 89 IS - 3 SN - 0002-9270, 0002-9270 KW - Hepatitis, Chronic KW - Human KW - Hepatitis, Alcoholic KW - Treatment Outcome KW - Liver Function Tests KW - Liver Cirrhosis, Biliary KW - Ursodeoxycholic Acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85226297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Ursodeoxycholic+therapy+in+chronic+liver+disease%3A+a+meta-analysis+in+primary+biliary+cirrhosis+and+in+chronic+hepatitis.&rft.au=Simko%2C+V%3BMichael%2C+S%3BPrego%2C+V&rft.aulast=Simko&rft.aufirst=V&rft.date=1994-03-01&rft.volume=89&rft.issue=3&rft.spage=392&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Splenic rupture: an unusual complication of colonoscopy. AN - 85221665; pmid-8122666 JF - The American Journal of Gastroenterology AU - Heath, B AU - Rogers, A AU - Taylor, A AU - Lavergne, J AD - Department of Medicine and Gastroenterology, Miami Veterans Administration Hospital, Florida. PY - 1994 SP - 449 EP - 450 VL - 89 IS - 3 SN - 0002-9270, 0002-9270 KW - Colonoscopy KW - Human KW - Tomography, X-Ray Computed KW - Aged KW - Spleen KW - Case Report KW - Splenic Rupture KW - Male UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85221665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Splenic+rupture%3A+an+unusual+complication+of+colonoscopy.&rft.au=Heath%2C+B%3BRogers%2C+A%3BTaylor%2C+A%3BLavergne%2C+J&rft.aulast=Heath&rft.aufirst=B&rft.date=1994-03-01&rft.volume=89&rft.issue=3&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Cigarette smoke aggravates acid-induced duodenal mucosal injury in the rat. Role of mesenteric vasoconstriction. AN - 76548686; 8209179 AB - In anesthetized rats we tested the hypothesis that cigarette smoke potentiates acid-induced duodenal mucosal injury by inducing mesenteric vasoconstriction. Rats inhaled room air or 6 or 12 ml/min cigarette smoke. Study 1: 0.1 N HCl-induced duodenal mucosal injury and H+ loss were assessed by histologic evaluation and titration, respectively. Study 2: Superior mesenteric artery blood flow was assessed by pulsed Doppler flowmetry before and during inhalation of cigarette smoke or room air. Twelve milliliter per minute of cigarette smoke aggravated 0.1 N HCl-induced duodenal mucosal injury by significantly increasing the number of villi with deep villous damage. The increased damage was associated with significantly greater loss of H+ from the duodenal lumen. Cigarette smoke produced a dose-related reduction in mesenteric blood flow. We conclude that the vasoconstrictive effect of cigarette smoke on mesenteric blood flow may be involved in the potentiation of acid-induced duodenal mucosal injury. JF - Scandinavian journal of gastroenterology AU - Zhang, X Y AU - Leung, F W AD - Research and Medical Services, Sepulveda Veterans Administration Medical Center, UCLA School of Medicine. Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 214 EP - 218 VL - 29 IS - 3 SN - 0036-5521, 0036-5521 KW - Hydrochloric Acid KW - QTT17582CB KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Intestinal Mucosa -- pathology KW - Regional Blood Flow KW - Male KW - Vasoconstriction -- physiology KW - Duodenal Ulcer -- chemically induced KW - Duodenal Ulcer -- physiopathology KW - Duodenal Ulcer -- etiology KW - Smoking -- adverse effects KW - Mesenteric Artery, Superior -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76548686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+journal+of+gastroenterology&rft.atitle=Cigarette+smoke+aggravates+acid-induced+duodenal+mucosal+injury+in+the+rat.+Role+of+mesenteric+vasoconstriction.&rft.au=Zhang%2C+X+Y%3BLeung%2C+F+W&rft.aulast=Zhang&rft.aufirst=X&rft.date=1994-03-01&rft.volume=29&rft.issue=3&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Scandinavian+journal+of+gastroenterology&rft.issn=00365521&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-07-13 N1 - Date created - 1994-07-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cell cycle arrest by prostaglandin A1 at the G1/S phase interface with up-regulation of oncogenes in S-49 cyc- cells. AN - 76540510; 8200906 AB - Our previous studies have implied that prostaglandins inhibit cell growth independent of cAMP. Recent reports, however, have suggested that prostaglandin arrest of the cell cycle may be mediated through protein kinase A. In this report, in order to eliminate the role of c-AMP in prostaglandin mediated cell cycle arrest, we use the -49 lymphoma variant (cyc-) cells that lack adenylate cyclase activity. We demonstrate that dimethyl prostaglandin A1 (dmPGA1) inhibits DNA synthesis and cell growth in cyc- cells. DNA synthesis is inhibited 42% by dmPGA1 (50 microM) despite the fact that this cell line lacks cellular components needed for cAMP generation. The ability to decrease DNA synthesis depends upon the specific prostaglandin structure with the most effective form possessing the alpha, beta unsaturated ketone ring. Dimethyl PGA1 is most effective in inhibiting DNA synthesis in cyc- cells, with prostaglandins PGE1 and PGB1 being less potent inhibitors of DNA synthesis. DmPGE2 caused a significant stimulation of DNA synthesis. S-49 cyc- variant cells exposed to (30-50 microns) dmPGA1, arrested in the G1 phase of the cell cycle within 24 h. This growth arrest was reversed when the prostaglandin was removed from the cultured cells; growth resumed within hours showing that this treatment is not toxic. The S-49 cyc- cells were chosen not only for their lack of adenylate cyclase activity, but also because their cell cycle has been extensively studied and time requirements for G1, S, G2, and M phases are known. Within hours after prostaglandin removal the cells resume active DNA synthesis, and cell number doubles within 15 h suggesting rapid entry into S-phase DNA synthesis from the G1 cell cycle block.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Journal of cellular biochemistry AU - Hughes-Fulford, M AD - Research Service, Veterans Administration Medical Center, San Francisco, California 94121. Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 265 EP - 272 VL - 54 IS - 3 SN - 0730-2312, 0730-2312 KW - c-fos KW - c-jun KW - c-myc KW - DNA, Neoplasm KW - 0 KW - Prostaglandins A, Synthetic KW - 16,16-dimethylprostaglandin A1 KW - 5668IJK40E KW - Cyclic AMP KW - E0399OZS9N KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Index Medicus KW - Space life sciences KW - NASA Discipline Cell Biology KW - Non-NASA Center KW - Animals KW - Tumor Cells, Cultured KW - Mice KW - Genes, myc -- drug effects KW - DNA, Neoplasm -- biosynthesis KW - DNA Replication -- drug effects KW - Structure-Activity Relationship KW - Prostaglandins A, Synthetic -- pharmacology KW - S Phase -- drug effects KW - Interphase -- drug effects KW - Genes, jun -- drug effects KW - Genes, fos -- drug effects KW - Cyclic AMP -- physiology KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Adenylyl Cyclases -- deficiency KW - Adenylyl Cyclases -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76540510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+biochemistry&rft.atitle=Cell+cycle+arrest+by+prostaglandin+A1+at+the+G1%2FS+phase+interface+with+up-regulation+of+oncogenes+in+S-49+cyc-+cells.&rft.au=Hughes-Fulford%2C+M&rft.aulast=Hughes-Fulford&rft.aufirst=M&rft.date=1994-03-01&rft.volume=54&rft.issue=3&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+biochemistry&rft.issn=07302312&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-07-05 N1 - Date created - 1994-07-05 N1 - Date revised - 2017-01-13 N1 - Gene symbol - c-fos; c-jun; c-myc N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Physiological changes due to age. Implications for respiratory drug therapy. AN - 76521311; 8199395 AB - The pulmonary system is modified in various ways over time and it is particularly vulnerable to environmental insults. Of particular interest are the implications of aging for therapy of respiratory illnesses. The changes in pulmonary structure and function due simply to aging, and changes due to diseases, should be distinguished from each other. The great reserve function of the lung permits reasonable physical capacity in healthy individuals despite aging changes. In principle, loss of function equivalent to more than one lung is necessary to impair aerobic capacity at any age. Elderly people are subject to the same respiratory diseases as younger adults but may manifest them differently. They may present in atypical ways such as in bacterial pneumonia, tuberculosis, and asthma, all modified by anatomical alterations or deterioration of immunological defence mechanisms. Accumulation of toxic substances over time such as cigarette smoke or environmental pollutants may give rise to chronic bronchitis, emphysema, bronchogenic carcinoma and interstitial lung disease. Changes in the number or function of airway receptors modulate responses to bronchodilator drugs. Chronic inflammation of the bronchial wall has blurred the distinction between traditional asthma and chronic bronchitis and emphysema, and similar drug therapy can be useful for all. Adverse reactions to respiratory drugs such as theophylline, oral corticosteroids, and isoniazid increase with age. As more data accumulate, drug therapy of respiratory diseases in older patients will become more effective and safer. JF - Drugs & aging AU - Morris, J F AD - Veterans Administration Medical Centre, Portland, Oregon. Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 207 EP - 220 VL - 4 IS - 3 SN - 1170-229X, 1170-229X KW - Index Medicus KW - Humans KW - Aged KW - Aging -- physiology KW - Respiratory Tract Diseases -- drug therapy KW - Aging -- pathology KW - Respiratory Tract Diseases -- physiopathology KW - Respiratory Physiological Phenomena UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76521311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drugs+%26+aging&rft.atitle=Physiological+changes+due+to+age.+Implications+for+respiratory+drug+therapy.&rft.au=Morris%2C+J+F&rft.aulast=Morris&rft.aufirst=J&rft.date=1994-03-01&rft.volume=4&rft.issue=3&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Drugs+%26+aging&rft.issn=1170229X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-07-05 N1 - Date created - 1994-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Emergencies caused by side effects of psychiatric medications. AN - 76439221; 8161398 AB - Psychiatric medications cause side effects in several organ systems that need emergency evaluation and treatment. Serious cardiovascular side effects include postural hypotension, cardiac conduction blockade, and SA mode dysfunction; serious neurological side effects include extrapyramidal reactions, seizures, delirium, catatonia, pseudotumor cerebri, ataxia, and glaucoma; serious genitourinary side effects include urinary retention, nephrotic syndrome, and priapism, and the serious hematological side effect of agranulocytosis. Also potentially fatal syndromes secondary to psychiatric drugs are the neuroleptic malignant syndrome, hyperandrenergic crisis, the serotonin syndrome, and lithium toxicity. Individual psychiatric drug classes most notorious for causing side effects with high morbidity and mortality are low potency neuroleptics, clozapine, tertiary tricyclics, monoamine oxidase inhibitors, and lithium. JF - The American journal of emergency medicine AU - Tueth, M J AD - Department of Psychiatry, Veterans Administration Medical Center, Gainesville, FL 32608. Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 212 EP - 216 VL - 12 IS - 2 SN - 0735-6757, 0735-6757 KW - Psychotropic Drugs KW - 0 KW - Index Medicus KW - Humans KW - Emergencies KW - Emergency Service, Hospital KW - Nervous System Diseases -- epidemiology KW - Psychotropic Drugs -- classification KW - Cardiovascular Diseases -- epidemiology KW - Nervous System Diseases -- therapy KW - Cardiovascular Diseases -- therapy KW - Agranulocytosis -- epidemiology KW - Cardiovascular Diseases -- chemically induced KW - Psychotropic Drugs -- adverse effects KW - Nervous System Diseases -- chemically induced KW - Cardiovascular Diseases -- diagnosis KW - Nervous System Diseases -- diagnosis KW - Agranulocytosis -- chemically induced KW - Agranulocytosis -- therapy KW - Agranulocytosis -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76439221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+emergency+medicine&rft.atitle=Emergencies+caused+by+side+effects+of+psychiatric+medications.&rft.au=Tueth%2C+M+J&rft.aulast=Tueth&rft.aufirst=M&rft.date=1994-03-01&rft.volume=12&rft.issue=2&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+emergency+medicine&rft.issn=07356757&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-05-20 N1 - Date created - 1994-05-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Experience with intracavernosal tri-mixture for the management of neurogenic erectile dysfunction. AN - 76391918; 8129578 AB - Using papaverine, papaverine/phentolamine, or prostaglandin E1 (PGE1), intracavernosal pharmacotherapy has been successful in treating erectile dysfunction. The limiting factor of using these medicines is intracorporeal fibrosis with the first two and a high cost with PGE1. Our experience with intracavernosal therapy in patients with impotence secondary to neurogenic disease has included 35 men, 30 of whom are spinal cord injured, 3 after radical prostatectomy, 1 with multiple sclerosis, and 1 with lower extremity weakness after surgery. Patients ranged in age from 22 to 59 years, with an average of 36.3 years; mean follow-up was 13.8 months. Intracavernosal therapy has been performed with a tri-mixture of papaverine hydrochloride (smooth muscle relaxant), phentolamine mesylate (alpha-adrenergic blocking agent) and alprostadil (PGE1- a vasodilator and smooth muscle relaxant). Of the patient population, all 35 patients were able to have adequate erections for sexual relations with minimal complications. Acting synergistically, the ingredients promote erectile activity using small doses and without a significant incidence of priapism or fibrosis. Techniques of injection, dosing and followup are discussed. JF - Archives of physical medicine and rehabilitation AU - Chao, R AU - Clowers, D E AD - Department of Urology and Spinal Cord Injury, Veterans Administration Medical Center, Seattle, WA. Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 276 EP - 278 VL - 75 IS - 3 SN - 0003-9993, 0003-9993 KW - Drug Combinations KW - 0 KW - Papaverine KW - DAA13NKG2Q KW - Alprostadil KW - F5TD010360 KW - Phentolamine KW - Z468598HBV KW - Abridged Index Medicus KW - Index Medicus KW - Patient Satisfaction KW - Fibrosis KW - Humans KW - Drug Costs KW - Penile Diseases -- pathology KW - Cost-Benefit Analysis KW - Adult KW - Drug Monitoring KW - Priapism -- chemically induced KW - Penile Diseases -- chemically induced KW - Follow-Up Studies KW - Middle Aged KW - Drug Synergism KW - Injections KW - Male KW - Alprostadil -- pharmacology KW - Phentolamine -- pharmacology KW - Multiple Sclerosis -- complications KW - Papaverine -- economics KW - Erectile Dysfunction -- drug therapy KW - Papaverine -- therapeutic use KW - Erectile Dysfunction -- etiology KW - Phentolamine -- economics KW - Alprostadil -- economics KW - Papaverine -- pharmacology KW - Spinal Cord Injuries -- complications KW - Prostatectomy -- adverse effects KW - Alprostadil -- therapeutic use KW - Erectile Dysfunction -- physiopathology KW - Penile Erection -- drug effects KW - Phentolamine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76391918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+physical+medicine+and+rehabilitation&rft.atitle=Experience+with+intracavernosal+tri-mixture+for+the+management+of+neurogenic+erectile+dysfunction.&rft.au=Chao%2C+R%3BClowers%2C+D+E&rft.aulast=Chao&rft.aufirst=R&rft.date=1994-03-01&rft.volume=75&rft.issue=3&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Archives+of+physical+medicine+and+rehabilitation&rft.issn=00039993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-04-12 N1 - Date created - 1994-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular characterization of human hepatic lipase deficiency. In vitro expression of two naturally occurring mutations. AN - 76376774; 8123642 AB - Individuals with hepatic lipase (HL) deficiency are often characterized by elevated levels of triglycerides and cholesterol and may be subject to premature atherosclerosis. Missense mutations in the HL gene have been identified in two affected families: substitutions of serine for phenylalanine at amino acid 267 and threonine for methionine at amino acid 383 (S267F and T383M, respectively). To confirm the role of S267F and T383M, respectively). To confirm the role of mutations separately into human HL cDNA by site-directed mutagenesis, and the resulting constructs were independently expressed in COS cells. HL activity and mass were measured and compared with wild-type HL transfectants to determine the effect of these mutations on lipase activity and secretion. Although similar amounts of HL protein were detected intracellularly after transfection with the wild-type and mutant constructs, S267F and T383M HL activity levels were markedly decreased: in S267F, no HL activity was detected, and activity levels in T383M were 38% of wild-type HL. Heparin-induced secretion of the two HL mutants was also severely affected: no detectable activity could be measured in the media of S267F, although some inactive mass (12% of wild-type HL) was secreted; mutant T383M secreted 4% and 20% of wild-type activity and mass, respectively. These results indicate that the single amino acid substitution present in HL S267F is sufficient to render the enzyme completely nonfunctional; in contrast, the T383M mutant retains partial activity but is poorly secreted. Thus, these defects appear capable of accounting for the HL-deficient phenotypes exhibited by individuals carrying the T383M and S267F mutations. JF - Arteriosclerosis and thrombosis : a journal of vascular biology AU - Durstenfeld, A AU - Ben-Zeev, O AU - Reue, K AU - Stahnke, G AU - Doolittle, M H AD - Lipid Research, Veterans Administration Wadsworth Medical Center, Los Angeles, CA 90073. Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 381 EP - 385 VL - 14 IS - 3 SN - 1049-8834, 1049-8834 KW - Lipase KW - EC 3.1.1.3 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Humans KW - Molecular Sequence Data KW - Mutation KW - Liver -- enzymology KW - Lipase -- genetics KW - Lipase -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76376774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arteriosclerosis+and+thrombosis+%3A+a+journal+of+vascular+biology&rft.atitle=Molecular+characterization+of+human+hepatic+lipase+deficiency.+In+vitro+expression+of+two+naturally+occurring+mutations.&rft.au=Durstenfeld%2C+A%3BBen-Zeev%2C+O%3BReue%2C+K%3BStahnke%2C+G%3BDoolittle%2C+M+H&rft.aulast=Durstenfeld&rft.aufirst=A&rft.date=1994-03-01&rft.volume=14&rft.issue=3&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Arteriosclerosis+and+thrombosis+%3A+a+journal+of+vascular+biology&rft.issn=10498834&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-04-12 N1 - Date created - 1994-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Are Older Pedestrians Allowed Enough Time to Cross Intersections Safely? AN - 61347556; 9411030 AB - To determine whether older pedestrians are at risk of injury at busy urban intersections, an experiment was conducted at the intersection of Third St & Fairfax Ave in Los Angeles, CA, involving all pedestrians (N = 1,229) who started to cross the intersection during the legally acceptable parts of the traffic cycle during 3 days of observation. Time taken in crossing the intersection was measured, & interviews were conducted with 139 pedestrians unable to meet the time limits. Out of 592 older pedestrians observed, 27% failed to reach the opposite curb before the light changed, with 25% of them stranded by at least a full traffic lane. Findings indicate that the timing of the pedestrian signal is inadequate for many older pedestrians to cross, placing them at potential risk. 2 Figures, 13 References. Adapted from the source document. JF - Journal of the American Geriatrics Society AU - Hoxie, Russell E AU - Rubenstein, Laurence Z AD - Veterans Administration Medical Center U California Los Angeles School Medicine, Sepulveda 91343 Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 241 EP - 244 VL - 42 IS - 3 SN - 0002-8614, 0002-8614 KW - busy urban intersection risks, elderly pedestrians KW - observation/interview data KW - Los Angeles, California KW - Risk KW - Accidents KW - Collective Behavior KW - Urban Areas KW - Elderly KW - Traffic KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61347556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Are+Older+Pedestrians+Allowed+Enough+Time+to+Cross+Intersections+Safely%3F&rft.au=Hoxie%2C+Russell+E%3BRubenstein%2C+Laurence+Z&rft.aulast=Hoxie&rft.aufirst=Russell&rft.date=1994-03-01&rft.volume=42&rft.issue=3&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JAGSAF N1 - SubjectsTermNotLitGenreText - Elderly; Collective Behavior; Accidents; Traffic; Los Angeles, California; Risk; Urban Areas ER - TY - JOUR T1 - A Model of Homelessness among Male Veterans of the Vietnam War Generation AN - 61335740; 9411410 AB - Using data from a 1986/87 national survey of Vietnam war veterans, a multifactorial model of homelessness among men (N = 1,460) who served in the US military 1964-1975 is constructed. Although none of the veterans were homeless at the time of the survey, 8.4% said they had been homeless for at least 1 month in the past. The findings indicate that the vulnerability to homelessness accumulates over time & involves multiple aspects of social isolation (having had a low level of support during the year after discharge & being unmarried), psychiatric illness, & antisocial conduct (especially drug use). Unexpectedly, childhood poverty & minority racial/ethnic status do not increase the vulnerability to homelessness. 2 Tables, 1 Figure, 31 References. M. Maguire JF - The American Journal of Psychiatry AU - Rosenheck, Robert AU - Fontana, Alan AD - Northeast Program Evaluation Center Veterans Administration Medical Center, 950 Campbell Ave West Haven CT 06516 Y1 - 1994/03// PY - 1994 DA - March 1994 SP - 421 EP - 427 VL - 151 IS - 3 SN - 0002-953X, 0002-953X KW - male Vietnam war veterans, multifactorial homelessness model KW - 1986/87 national survey data KW - Veterans KW - Vietnam War KW - Males KW - United States of America KW - Homelessness KW - article KW - 2793: studies in poverty; homelessness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61335740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=A+Model+of+Homelessness+among+Male+Veterans+of+the+Vietnam+War+Generation&rft.au=Rosenheck%2C+Robert%3BFontana%2C+Alan&rft.aulast=Rosenheck&rft.aufirst=Robert&rft.date=1994-03-01&rft.volume=151&rft.issue=3&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJPSAO N1 - SubjectsTermNotLitGenreText - Vietnam War; Veterans; Homelessness; Males; United States of America ER - TY - JOUR T1 - Activation of beta-isozyme of protein kinase C (PKC beta) is necessary and sufficient for phorbol ester-induced differentiation of HL-60 promyelocytes. Studies with PKC beta-defective PET mutant. AN - 76349980; 8308000 AB - 12-O-Tetradecanoylphorbol-13-acetate (TPA) induces growth arrest and differentiation of a number of leukemia cell lines including HL-60 human promyelocytic leukemia. We investigated the involvement of protein kinase C (PKC) isotypes in phorbol ester-induced differentiation using the phorbol ester-tolerant PET mutant of HL-60 cells, which (in contrast to the parent phorbol ester-sensitive (wild-type) S variant of HL-60 cells) does not growth-arrest, become adherent, or undergo apoptosis when exposed to TPA (Macfarlane, D. E., Gailani, D., and Vann, K. (1988) Br. J. Haematol. 68, 291-302). In comparison to S cells, we found that proliferating PET cells markedly underexpress mRNA for PKC beta, but do express PKC alpha and PKC delta. The PKC beta-selective activator 12-deoxyphorbol 13-phenylacetate 20-acetate induces growth arrest, adherence, surface expression of CD11a, and apoptosis in S cells, but not in PET cells. Expression of PKC beta in PET cells can be restored by exposing them to dihydroxyvitamin D3, and this treatment restores the ability of subsequently added 12-deoxyphorbol 13-phenylacetate 20-acetate or TPA to induce immediate cell adherence and growth arrest of PET cells. These data led us to conclude that activation of PKC beta is both necessary and sufficient for phorbol ester-induced growth arrest and adherence in these myeloid cells. JF - The Journal of biological chemistry AU - Macfarlane, D E AU - Manzel, L AD - Department of Medicine, Veterans Administration Hospital, Iowa City, Iowa. Y1 - 1994/02/11/ PY - 1994 DA - 1994 Feb 11 SP - 4327 EP - 4331 VL - 269 IS - 6 SN - 0021-9258, 0021-9258 KW - Isoenzymes KW - 0 KW - Lymphocyte Function-Associated Antigen-1 KW - Phorbol Esters KW - RNA, Messenger KW - Protein Kinase C KW - EC 2.7.11.13 KW - Calcitriol KW - FXC9231JVH KW - Index Medicus KW - Gene Expression -- drug effects KW - Lymphocyte Function-Associated Antigen-1 -- metabolism KW - DNA Damage KW - Enzyme Activation KW - Humans KW - Leukemia, Promyelocytic, Acute -- pathology KW - RNA, Messenger -- genetics KW - Calcitriol -- pharmacology KW - Isoenzymes -- metabolism KW - Tumor Cells, Cultured KW - Apoptosis -- drug effects KW - In Vitro Techniques KW - Cell Adhesion -- drug effects KW - Phorbol Esters -- pharmacology KW - Protein Kinase C -- deficiency KW - Protein Kinase C -- physiology KW - Cell Differentiation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76349980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Activation+of+beta-isozyme+of+protein+kinase+C+%28PKC+beta%29+is+necessary+and+sufficient+for+phorbol+ester-induced+differentiation+of+HL-60+promyelocytes.+Studies+with+PKC+beta-defective+PET+mutant.&rft.au=Macfarlane%2C+D+E%3BManzel%2C+L&rft.aulast=Macfarlane&rft.aufirst=D&rft.date=1994-02-11&rft.volume=269&rft.issue=6&rft.spage=4327&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-03-17 N1 - Date created - 1994-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determinants of survival in idiopathic pulmonary fibrosis. AN - 85273870; pmid-8306044 AB - To identify the determinants of survival in patients with idiopathic pulmonary fibrosis (IPF), we performed a survival analysis on 74 subjects with IPF. The study subjects were on average 64 yr of age (range, 25 to 83 yr), 62% were male, and 29% were never smokers. A tissue diagnosis was made in 67 (91%) of our study subjects. These subjects were followed for a mean period of 4 yr (range, 1.4 to 118.8 months) after the onset of pulmonary symptoms. During the period of observation, 41 subjects died (median survival = 28.2 months) and 33 continue to survive (median follow-up period = 60.9 months). A univariate analysis demonstrated that diminished survival was significantly associated with male gender (hazard ratio = 1.98; 95% confidence interval [CI] = 1.01-3.85), a higher FEV1/FVC ratio (hazard ratio = 1.82 [per 10% increase in the FEV1/FVC ratio]; 95% CI = 1.21-2.73), a lower percent predicted FVC (hazard ratio = 0.74; 95% CI = 0.60-0.91), a lower percent predicted total lung capacity (TLC) (hazard ratio = 0.75; 95% CI = 0.60-0.94), a lower percent predicted diffusing capacity of carbon monoxide (DLCO) (hazard ratio = 0.69; 95% CI = 0.53-0.89), a higher ILO profusion category on chest radiograph (hazard ratio = 3.52; 95% CI = 1.58-7.87), and an enhanced release of prostaglandin E2 (PGE2) by cultured alveolar macrophages (hazard ratio = 1.32 [per 10 pm/ml of PGE2]; 95% CI = 1.07-1.62).(ABSTRACT TRUNCATED AT 250 WORDS) JF - American Journal of Respiratory and Critical Care Medicine AU - Schwartz, D A AU - Helmers, R A AU - Galvin, J R AU - Van Fossen D S AU - Frees, K L AU - Dayton, C S AU - Burmeister, L F AU - Hunninghake, G W AD - Department of Internal Medicine, Department of Veterans Administration Medical Center, Iowa City, Iowa. PY - 1994 SP - 450 EP - 454 VL - 149 IS - 2 Pt 1 SN - 1073-449X, 1073-449X KW - Regression Analysis KW - Support, U.S. Gov't, P.H.S. KW - Sex Factors KW - Human KW - Predictive Value of Tests KW - Pulmonary Fibrosis KW - Smoking KW - Prospective Studies KW - Spirometry KW - Bronchoalveolar Lavage Fluid KW - Middle Age KW - Follow-Up Studies KW - Time Factors KW - Male KW - Female KW - Survival Analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85273870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Determinants+of+survival+in+idiopathic+pulmonary+fibrosis.&rft.au=Schwartz%2C+D+A%3BHelmers%2C+R+A%3BGalvin%2C+J+R%3BVan+Fossen+D+S%3BFrees%2C+K+L%3BDayton%2C+C+S%3BBurmeister%2C+L+F%3BHunninghake%2C+G+W&rft.aulast=Schwartz&rft.aufirst=D&rft.date=1994-02-01&rft.volume=149&rft.issue=2+Pt+1&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Forecasting the demand for inpatient services for specific chronic conditions. AN - 76670500; 8064208 AB - While the proposed forecasting methodology has a well-established record in evaluating economic time-series, there is minimal, if any, use of this technique in projecting hospitalizations for specific chronic conditions. Using an established taxonomy of disease codes for alcoholism and alcohol abuse in a national inpatient database, a monthly time-series of hospitalizations was modeled. The model derived in both statistically adequate and accurate in forecasting future monthly demand for inpatient hospitalizations. This type of model specifications could be used by hospital planners and policy makers in evaluating monthly resources for specific chronic conditions. JF - Journal of medical systems AU - Hisnanick, J J AD - U.S. Department of Veterans Affairs, National Center for Veterans Analysis & Statistics, Washington, DC 20420. Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 9 EP - 21 VL - 18 IS - 1 SN - 0148-5598, 0148-5598 KW - Index Medicus KW - Computer Simulation KW - Diagnosis-Related Groups KW - Humans KW - Alcoholism KW - Models, Statistical KW - Data Collection KW - Forecasting KW - Chronic Disease KW - Health Services Needs and Demand -- trends KW - Hospitalization -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76670500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medical+systems&rft.atitle=Forecasting+the+demand+for+inpatient+services+for+specific+chronic+conditions.&rft.au=Hisnanick%2C+J+J&rft.aulast=Hisnanick&rft.aufirst=J&rft.date=1994-02-01&rft.volume=18&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Journal+of+medical+systems&rft.issn=01485598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-09-22 N1 - Date created - 1994-09-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Detection of reduced acetaldehyde protein adducts using a unique monoclonal antibody. AN - 76519932; 8198215 AB - Acetaldehyde (AA), the major product of alcohol metabolism, has been shown to bind to proteins in vivo and form chemical adducts. These AA-protein adducts have been shown to alter protein structure and function and may result in tissue damage. Recent reports have shown that polyclonal antibodies can be produced that recognize proteins modified in vitro with AA in the presence of sodium cyanoborohydride (NaCNBH3), a strong reducing (R) agent. Antibodies prepared in this way have been shown to recognize proteins in the livers of rats fed alcohol chronically. Because multiple AA-protein adducts can be recognized by polyclonal antisera, and a variety of adducts may be formed in vitro or in vivo, this study was designed to develop monoclonal antibodies specific for proteins modified by AA. In addition, adducts formed under R conditions are probably chemically different than those formed under nonreducing (NR) conditions, and monoclonal antibodies may provide the specificity required to distinguish these chemical differences. Balb/c mice were immunized with bovine brain tubulin that was modified by treatment with 5 mM AA for 7 days under NR conditions. Sera from immunized animals were tested for antibody activity to the immunogen (protein-NR) and for cross-reactivity to protein-R and unmodified protein. Although the highest serum antibody titers were seen toward the NR adduct, antibodies to the R adduct were also detected. This activity difference was independent of the carrier protein, because NR and R bovine serum albumin, keyhole limpet hemocyanin, and actin also gave similar results when used as the adducted protein.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Alcoholism, clinical and experimental research AU - Klassen, L W AU - Tuma, D J AU - Sorrell, M F AU - McDonald, T L AU - DeVasure, J M AU - Thiele, G M AD - Alcohol Research Center, Omaha Veterans Administration Medical Center, Nebraska. Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 164 EP - 171 VL - 18 IS - 1 SN - 0145-6008, 0145-6008 KW - Antibodies, Monoclonal KW - 0 KW - Proteins KW - Serum Albumin, Bovine KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Animals KW - Cytosol -- metabolism KW - Alcoholism -- metabolism KW - Liver -- metabolism KW - Mice KW - Rabbits KW - Mice, Inbred BALB C KW - Rats KW - Antibody Specificity KW - Protein Binding -- physiology KW - Rats, Sprague-Dawley KW - Cattle KW - Serum Albumin, Bovine -- metabolism KW - Male KW - Acetaldehyde -- metabolism KW - Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76519932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Detection+of+reduced+acetaldehyde+protein+adducts+using+a+unique+monoclonal+antibody.&rft.au=Klassen%2C+L+W%3BTuma%2C+D+J%3BSorrell%2C+M+F%3BMcDonald%2C+T+L%3BDeVasure%2C+J+M%3BThiele%2C+G+M&rft.aulast=Klassen&rft.aufirst=L&rft.date=1994-02-01&rft.volume=18&rft.issue=1&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-06-30 N1 - Date created - 1994-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The alcohol withdrawal syndrome. AN - 76449514; 8161860 JF - Rhode Island medicine AU - Berard, R G AD - Substance Abuse Program, Veterans Administration Medical Center, Providence, Rhode Island. Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 47 EP - 48 VL - 77 IS - 2 SN - 1061-222X, 1061-222X KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Humans KW - Ethanol -- adverse effects KW - Substance Withdrawal Syndrome -- physiopathology KW - Substance Withdrawal Syndrome -- diagnosis KW - Substance Withdrawal Syndrome -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76449514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rhode+Island+medicine&rft.atitle=The+alcohol+withdrawal+syndrome.&rft.au=Berard%2C+R+G&rft.aulast=Berard&rft.aufirst=R&rft.date=1994-02-01&rft.volume=77&rft.issue=2&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Rhode+Island+medicine&rft.issn=1061222X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-05-24 N1 - Date created - 1994-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Elimination of the antianalgesic action of dynorphin A by spinal transsection in barbital-anesthetized mice. AN - 76369554; 7906735 AB - Previous studies in mice demonstrate that, when dynorphin A (1-17) (Dyn A) is administered intrathecally (i.t.) or released spinally (by administration of clonidine or midazolam i.c.v.), i.t. morphine-induced analgesia was reduced. The present aim was to determine whether this antianalgesic action of Dyn A was the result of a spinal or supraspinal site of action by performing studies in spinally transsected mice. The approach was to use anesthetized, acute spinally transsected mice rather than chronic spinally transsected animals to avoid the need for long-term special animal care. The first part of the study evaluated four nonvolatile general anesthetic agents in an attempt to obtain one that did not affect the antianalgesic action of Dyn A, the release of Dyn A, the analgesic action of i.t. morphine (inhibition of the tail-flick response) or the tail-flick latency by itself. alpha-Chloralose (120 mg/kg), urethane (1 g/kg) and pentobarbital (20 or 40 mg/kg) given i.p. did not meet one or more of these requirements. Barbital 400 mg/kg i.p. met the requirements. In the second part of the study, barbital combined with halothane anesthesia was used to perform acute spinal transsection experiments. As in sham controls, the analgesic action of i.t. morphine was undiminished in spinally transsected animals, which indicated that the inhibition of the tail-flick response produced by i.t. morphine was on a spinal reflex response. On the other hand, spinal transsection produced a loss of the action of i.t. Dyn A to antagonize i.t. morphine-induced analgesia.(ABSTRACT TRUNCATED AT 250 WORDS) JF - The Journal of pharmacology and experimental therapeutics AU - Wang, F S AU - Rady, J J AU - Fujimoto, J M AD - Department of Pharmacology and Toxicology, Veterans Administration Medical Center, Milwaukee, Wisconsin. Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 873 EP - 880 VL - 268 IS - 2 SN - 0022-3565, 0022-3565 KW - Chloralose KW - 238BZ29MUE KW - Urethane KW - 3IN71E75Z5 KW - Barbital KW - 5WZ53ENE2P KW - Dynorphins KW - 74913-18-1 KW - Pentobarbital KW - I4744080IR KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Chloralose -- pharmacology KW - Anesthesia KW - Mice KW - Urethane -- pharmacology KW - Male KW - Analgesia KW - Spinal Cord -- physiology KW - Dynorphins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76369554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Elimination+of+the+antianalgesic+action+of+dynorphin+A+by+spinal+transsection+in+barbital-anesthetized+mice.&rft.au=Wang%2C+F+S%3BRady%2C+J+J%3BFujimoto%2C+J+M&rft.aulast=Wang&rft.aufirst=F&rft.date=1994-02-01&rft.volume=268&rft.issue=2&rft.spage=873&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-03-28 N1 - Date created - 1994-03-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationship of positive and negative symptoms to cocaine abuse in schizophrenia. AN - 76350177; 8308528 AB - The prevalence of cocaine abuse by patients with schizophrenia has led researchers to investigate features of the disorder correlated with abuse. Although abuse has been found to be more common among patients with a diagnosis of paranoid subtype and a history of earlier and more frequent hospitalizations, it is unclear if it is related to any particular pattern of negative or positive symptoms. This study examines the severity of positive and negative symptoms for patients with and without histories of cocaine abuse. Subjects with a history of at least 2 months of cocaine abuse (N = 25), no lifetime substance abuse (N = 20), and 2 months of alcohol abuse with no other substance abuse (N = 23) are compared on five-factor analytically and three rationally derived scores from the Positive and Negative Syndrome Scale (PANSS). Following a multivariate analyses of variance (p < .01), univariate analyses indicated significant differences on the negative syndrome scales, with cocaine-abusing subjects exhibiting less severe negative symptoms than subjects with no substance-abuse history. Cocaine-abusing subjects were also found to have been younger at time of first psychiatric hospitalization and more likely to qualify for a diagnosis of the paranoid subtype. JF - The Journal of nervous and mental disease AU - Lysaker, P AU - Bell, M AU - Beam-Goulet, J AU - Milstein, R AD - Psychology Service 116-B, West Haven Veterans Administration Medical Center, Connecticut 06516. Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 109 EP - 112 VL - 182 IS - 2 SN - 0022-3018, 0022-3018 KW - Cocaine KW - I5Y540LHVR KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Analysis of Variance KW - Schizophrenia, Paranoid -- psychology KW - Schizophrenia, Paranoid -- diagnosis KW - Psychiatric Status Rating Scales KW - Psychotic Disorders -- psychology KW - Humans KW - Schizophrenia, Paranoid -- epidemiology KW - Psychotic Disorders -- diagnosis KW - Psychotic Disorders -- epidemiology KW - Comorbidity KW - Prevalence KW - Substance-Related Disorders -- diagnosis KW - Schizophrenia -- diagnosis KW - Schizophrenic Psychology KW - Schizophrenia -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76350177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nervous+and+mental+disease&rft.atitle=Relationship+of+positive+and+negative+symptoms+to+cocaine+abuse+in+schizophrenia.&rft.au=Lysaker%2C+P%3BBell%2C+M%3BBeam-Goulet%2C+J%3BMilstein%2C+R&rft.aulast=Lysaker&rft.aufirst=P&rft.date=1994-02-01&rft.volume=182&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nervous+and+mental+disease&rft.issn=00223018&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-03-15 N1 - Date created - 1994-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determinants of progression in idiopathic pulmonary fibrosis. AN - 76347028; 8306043 AB - Idiopathic pulmonary fibrosis (IPF) is a progressive form of lung disease with a median survival of less than 5 yr. To address the progressive nature of this disease process, we investigated the determinants of decrements in lung function in patients with IPF. We prospectively evaluated 39 subjects with IPF. Our study subjects were followed for an average of 2 yr (range, 49 to 1,883 days) and lung function was measured on at least two separate occasions (mean = 9.1 separate tests) during the follow-up period. Since IPF is characterized by reduced lung volume and abnormal gas exchange, our analysis focused on the determinants of total lung capacity (TLC) and diffusing capacity of carbon monoxide (DLCO) during the period of observation. Although, on average, there was a 5.3% increase in the TLC and a 9.8% increase in DLCO between the first and last measure of lung function, 25% of the study population experienced a decline in the TLC and 28% of the study population experienced a decline in the DLCO. Decrements in TLC were independently associated with severe dyspnea (p = 0.01) and treatment with cyclophosphamide (p = 0.03). Decrements in DLCO were significantly and independently associated with more pack-years of cigarette smoking (p = 0.02), moderate (p = 0.03) or severe (p = 0.02) dyspnea, and treatment with cyclophosphamide (p = 0.0002). These findings indicate that several clinical characteristics are independently associated with subsequent declines in TLC and DLCO in patients with IPF.(ABSTRACT TRUNCATED AT 250 WORDS) JF - American journal of respiratory and critical care medicine AU - Schwartz, D A AU - Van Fossen, D S AU - Davis, C S AU - Helmers, R A AU - Dayton, C S AU - Burmeister, L F AU - Hunninghake, G W AD - Department of Internal Medicine, Department of Veterans Administration Medical Center, Iowa City, Iowa. Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 444 EP - 449 VL - 149 IS - 2 Pt 1 SN - 1073-449X, 1073-449X KW - Cyclophosphamide KW - 8N3DW7272P KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Pulmonary Diffusing Capacity -- physiology KW - Smoking -- epidemiology KW - Multivariate Analysis KW - Spirometry KW - Cyclophosphamide -- therapeutic use KW - Prospective Studies KW - Total Lung Capacity -- physiology KW - Risk Factors KW - Follow-Up Studies KW - Middle Aged KW - Time Factors KW - Bronchoalveolar Lavage Fluid -- cytology KW - Female KW - Male KW - Pulmonary Fibrosis -- diagnosis KW - Pulmonary Fibrosis -- drug therapy KW - Pulmonary Fibrosis -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76347028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Determinants+of+progression+in+idiopathic+pulmonary+fibrosis.&rft.au=Schwartz%2C+D+A%3BVan+Fossen%2C+D+S%3BDavis%2C+C+S%3BHelmers%2C+R+A%3BDayton%2C+C+S%3BBurmeister%2C+L+F%3BHunninghake%2C+G+W&rft.aulast=Schwartz&rft.aufirst=D&rft.date=1994-02-01&rft.volume=149&rft.issue=2+Pt+1&rft.spage=444&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-03-17 N1 - Date created - 1994-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aflatoxin B1-adduct formation in rat and human small bowel enterocytes. AN - 76343623; 8299909 AB - Hepatic CYP3A enzymes have been implicated in the bioactivation of aflatoxin B1 (AFB1) to DNA binding metabolites. CYP3A enzymes are also abundant in the small bowel, and we therefore examined the ability of this tissue to form intracellular AFB1 adducts. Immunohistochemistry using a antibody to the stable AFB1-DNA adduct was performed on small bowel sections obtained from rats orally gavaged with AFB1 and on human small bowel biopsy specimens maintained in explant culture. 3H-AFB1 was instilled into a loop of small bowel of untreated rats and rats pretreated with the CYP3A inducer dexamethasone during vivisection. DNA was isolated from the loop 2 hours later and assayed for specific activity. In both rats and humans, AFB1-adducts were detected exclusively in mature enterocytes in a pattern similar to the distribution of CYP3A enzymes. Induction of enterocyte CYP3A in rats resulted in an increase in enterocyte immunoreactive AFB1 adducts and in a 1.8-fold increase in 3H-AFB1-nucleic acid adducts (P = 0.01). Intracellular AFB1 adducts are formed in the small intestine, and this reflects, at least in part, the catalytic activity of CYP3A enzymes. Because these AFB1 adducts should ultimately pass in stool, enterocyte CYP3A may represent a regulatable barrier to dietary aflatoxins. JF - Gastroenterology AU - Kolars, J C AU - Benedict, P AU - Schmiedlin-Ren, P AU - Watkins, P B AD - Department of Internal Medicine, Veterans Administration Medical Center, Ann Arbor, Michigan. Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 433 EP - 439 VL - 106 IS - 2 SN - 0016-5085, 0016-5085 KW - DNA Adducts KW - 0 KW - Isoenzymes KW - aflatoxin B1-DNA adduct KW - DNA KW - 9007-49-2 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Isoenzymes -- physiology KW - Cytochrome P-450 Enzyme System -- genetics KW - Humans KW - Cytochrome P-450 Enzyme System -- physiology KW - Immunohistochemistry KW - Female KW - Aflatoxin B1 -- metabolism KW - Intestine, Small -- cytology KW - DNA -- metabolism KW - Intestine, Small -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76343623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Aflatoxin+B1-adduct+formation+in+rat+and+human+small+bowel+enterocytes.&rft.au=Kolars%2C+J+C%3BBenedict%2C+P%3BSchmiedlin-Ren%2C+P%3BWatkins%2C+P+B&rft.aulast=Kolars&rft.aufirst=J&rft.date=1994-02-01&rft.volume=106&rft.issue=2&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-03-10 N1 - Date created - 1994-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ascitic fluid albumin and water flows in patients with alcoholic cirrhosis: effects of peritoneovenous shunting. AN - 76341221; 8301196 AB - Ascites labeled albumin and water kinetics were studied at steady state by intercompartmental clearances in cirrhotic patients whose ascites volumes ranged from 6.4 to 25.2 L. In 20 patients mean (+/- SD) ascitic fluid albumin clearance (equivalent to lymphatic absorption) was 3.5 +/- 1.9 L/day. In seven of them, lymphatic absorption was 3.4 +/- 0.8 L/day, total water absorption from ascitic fluid (outflow equals inflow at steady state) was 125.8 +/- 21.5 L/day. Vascular capillary water absorption (total minus lymphatic) was 122.4 +/- 21.4 L per 24 hours. Lymphatic absorption was less than 4% of total but accounted for all albumin absorbed (13.2 +/- 6.2 gm/day). Maximum lymphatic absorption was less than 10 L per 24 hours; peritoneovenous shunting augmented this function. Mean inflow water albumin concentration was 0.11 +/- 0.06 gm/L. If plasma albumin were diluted to concentration in ascites, calculated water inflow required would be 2.82 L/day. Actual inflow was 47 times that required. The major volume outflow path was through peritoneal venous capillaries; water and small-radius solute absorption through this route increased inflow water albumin concentration to ascites level. Concurrently, whole ascitic fluid was absorbed without sieving through lymphatics. Observed ascites albumin concentration in subjects with advanced cirrhosis was produced by water absorption from a large volume of dilute solution rather than dilution of a small inflow volume, in which albumin concentration originally was hyperoncotic to ascitic fluid. Large-volume transperitoneal water diversion from sources in high-pressure, extrahepatic splanchnic capillaries to absorption through parietal nonportal, low-pressure, peritoneal venous capillaries would significantly reduce portal plasma flow into liver and have deleterious systemic hemodynamic consequences. JF - The Journal of laboratory and clinical medicine AU - Stanley, M M AU - Belknap, S AU - Biliack, S A AU - Hartz, C E AU - Houk, J H AD - Hines Veterans Administration Hospital, IL. Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 206 EP - 217 VL - 123 IS - 2 SN - 0022-2143, 0022-2143 KW - Albumins KW - 0 KW - Iodine Radioisotopes KW - Serum Albumin, Radio-Iodinated KW - Tritium KW - 10028-17-8 KW - Abridged Index Medicus KW - Index Medicus KW - Lymphatic System -- metabolism KW - Humans KW - Absorption KW - Albumins -- metabolism KW - Liver Cirrhosis, Alcoholic -- metabolism KW - Liver Cirrhosis, Alcoholic -- surgery KW - Body Water -- metabolism KW - Ascitic Fluid -- metabolism KW - Peritoneovenous Shunt UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76341221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+laboratory+and+clinical+medicine&rft.atitle=Ascitic+fluid+albumin+and+water+flows+in+patients+with+alcoholic+cirrhosis%3A+effects+of+peritoneovenous+shunting.&rft.au=Stanley%2C+M+M%3BBelknap%2C+S%3BBiliack%2C+S+A%3BHartz%2C+C+E%3BHouk%2C+J+H&rft.aulast=Stanley&rft.aufirst=M&rft.date=1994-02-01&rft.volume=123&rft.issue=2&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+laboratory+and+clinical+medicine&rft.issn=00222143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-03-10 N1 - Date created - 1994-03-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Lab Clin Med. 1994 Sep;124(3):455-6 [8083589] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - HIV-Associated Psychosis: A Study of 20 Cases AN - 61621438; 199402990 AB - New-onset psychosis as a result of HIV (human immunodeficiency virus) infection was evaluated with 20 HIV-infected psychotic males in a San Diego, CA, research center, & with 20 HIV-infected nonpsychotic males matched on age, race, gender, level of education, & HIV stage. Psychiatric, neuropsychological, & physical data were obtained. The psychotic patients had a variety of diagnoses, & their clinical courses were variable. These patients tended to have greater global neuropsychological impairment, a higher mortality rate, & a higher lifetime prevlance of stimulant or sedative/hypnotic drug abuse or dependence. The explanation that psychosis is secondary to HIV encephalopathy was supported, while those positing psychosis as the result of brain damage from infectious agents secondary to HIV, or us a result of stress from HIV, were not supported. 1 Table, 37 References. M. Pflum JF - The American Journal of Psychiatry AU - Sewell, Daniel D AU - Jeste, Dilip V AU - Atkinson, J Hampton AU - Heaton, Robert K AU - Hesselink, John R AU - Wiley, Clayton AU - Thal, Leon AU - Chandler, James L AU - Grant, Igor AD - Veterans Administration Medical Center, 3350 La Jolla Village Dr San Diego CA 92161 Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 237 EP - 242 VL - 151 IS - 2 SN - 0002-953X, 0002-953X KW - human immunodeficiency virus-associated psychosis KW - medical records KW - males, California KW - California KW - Psychosis KW - Acquired Immune Deficiency Syndrome KW - article KW - 6126: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61621438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=HIV-Associated+Psychosis%3A+A+Study+of+20+Cases&rft.au=Sewell%2C+Daniel+D%3BJeste%2C+Dilip+V%3BAtkinson%2C+J+Hampton%3BHeaton%2C+Robert+K%3BHesselink%2C+John+R%3BWiley%2C+Clayton%3BThal%2C+Leon%3BChandler%2C+James+L%3BGrant%2C+Igor&rft.aulast=Sewell&rft.aufirst=Daniel&rft.date=1994-02-01&rft.volume=151&rft.issue=2&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; California; Psychosis ER - TY - JOUR T1 - Conducting Simultaneous Large Multi-Site Evaluations on Parallel Topics AN - 1761707827; 199504453 AB - Before implementing new systems for procurement & delivery of pharmaceuticals, the US Dept of Veterans Affairs (VA) tested two: the USXPRESS system, which uses national contracts to purchase frequently used pharmaceuticals at low cost; & the Prime Vendor system, which uses Federal Supply Schedule contracts to obtain the best price on pharmaceuticals in the local market. The Midwest Health Services Research & Development field program compared 31 VA hospitals using the USXPRESS system with 33 using the Prime Vendor system & 32 comparison sites. USXPRESS yielded savings in storage space, pharmacy inventory, & transportation costs as well as increased overall satisfaction. Prime Vendor yielded savings in storage space & out-of-stock situations, as well as increased satisfaction with procurement policies. Thus, the advantages of both programs seem to outweigh the disadvantages. 1 Table, 5 References. M. Maguire JF - Evaluation Practice AU - Weaver, Frances M AD - Health Services Reseach & Development Veterans Administration Hospital, Hines IL 60141 Y1 - 1994/02// PY - 1994 DA - February 1994 SP - 37 EP - 44 VL - 15 IS - 1 SN - 0886-1633, 0886-1633 KW - pharmaceutical procurement/delivery systems, US Department of Veterans affairs KW - field test KW - Veterans KW - Purchasing KW - Government Agencies KW - Delivery Systems KW - Medications KW - United States of America KW - article KW - 7220: evaluation research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761707827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Evaluation+Practice&rft.atitle=Conducting+Simultaneous+Large+Multi-Site+Evaluations+on+Parallel+Topics&rft.au=Weaver%2C+Frances+M&rft.aulast=Weaver&rft.aufirst=Frances&rft.date=1994-02-01&rft.volume=15&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Evaluation+Practice&rft.issn=08861633&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Medications; Purchasing; Delivery Systems; Government Agencies; United States of America; Veterans ER - TY - JOUR T1 - Topography of a binding site for small amnestic peptides deduced from structure-activity studies: relation to amnestic effect of amyloid beta protein. AN - 76330619; 8278398 AB - Four peptides homologous to amyloid beta protein containing the Val-Phe-Phe (VFF) sequence administered intracerebroventricularly after training caused amnesia for footshock active avoidance training in mice. Results with VFF and other peptides containing VFF or portions thereof were used to generate a topographic map for a hypothetical binding surface for amnestic peptides, termed Z. Effects on retention of footshock active avoidance training were rationalized in terms of fit to Z, making possible design of potential memory-modulating peptidic and nonpeptidic substances. Three peptides that neither improved nor impaired retention blocked the amnestic effects of beta-(12-28), a peptide homologous to amyloid beta protein, opening the way to development of substances that can antagonize the neurotoxic effects of amyloid beta protein on neural structures and thus attenuate symptoms and progression of Alzheimer disease. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Flood, J F AU - Roberts, E AU - Sherman, M A AU - Kaplan, B E AU - Morley, J E AD - Geriatric Research Education and Clinical Center (GRECC), Veterans Administration Medical Center, St. Louis, MO 63106. Y1 - 1994/01/04/ PY - 1994 DA - 1994 Jan 04 SP - 380 EP - 384 VL - 91 IS - 1 SN - 0027-8424, 0027-8424 KW - Amyloid beta-Peptides KW - 0 KW - Peptides KW - Index Medicus KW - Animals KW - Computer Simulation KW - Models, Molecular KW - Molecular Sequence Data KW - Peptides -- chemistry KW - Memory -- physiology KW - Mice KW - Amino Acid Sequence KW - Protein Structure, Tertiary KW - Peptides -- pharmacology KW - Amnesia KW - Structure-Activity Relationship KW - Avoidance Learning -- physiology KW - Amyloid beta-Peptides -- chemistry KW - Amyloid beta-Peptides -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76330619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Topography+of+a+binding+site+for+small+amnestic+peptides+deduced+from+structure-activity+studies%3A+relation+to+amnestic+effect+of+amyloid+beta+protein.&rft.au=Flood%2C+J+F%3BRoberts%2C+E%3BSherman%2C+M+A%3BKaplan%2C+B+E%3BMorley%2C+J+E&rft.aulast=Flood&rft.aufirst=J&rft.date=1994-01-04&rft.volume=91&rft.issue=1&rft.spage=380&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-02-04 N1 - Date created - 1994-02-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8130-4 [1381506] J Mol Biol. 1992 Nov 20;228(2):460-73 [1453457] Am J Physiol. 1993 Jan;264(1 Pt 1):C229-36 [8430771] Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1977-81 [8446617] Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7508-12 [7689220] Acta Biol Med Ger. 1982;41(7-8):647-52 [6183854] Science. 1983 Aug 19;221(4612):709-13 [6879170] Behav Neural Biol. 1986 Mar;45(2):230-9 [2421708] Peptides. 1990 Jan-Feb;11(1):163-7 [1692991] Peptides. 1990 Sep-Oct;11(5):933-8 [2178250] Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3363-6 [2014256] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The association of swallowing dysfunction and aspiration pneumonia. AN - 85156179; pmid-8131418 AB - The medical literature has emphasized that aspiration of gastric contents or oral bacteria is a common cause of aspiration pneumonia. Swallowing disorders have been implicated in this disease but not studied at the time that aspiration pneumonia was diagnosed. A significant difference was found in the incidence of videofluoroscopically confirmed oropharyngeal swallowing problems in a group of patients diagnosed with aspiration pneumonia (AP) when compared with patients with nonaspiration pneumonia (NAP). Six of the 9 patients in the AP group aspirated during the videofluoroscopic evaluation and 2 others were considered to be at risk for aspiration. None of the 7 NAP patients demonstrated swallowing problems or aspiration. A significant difference in oral transit time also occurred between the two groups. Liquid was found to have a significantly faster oral transit time than paste or a cookie. Pharyngeal transit times were not found to be significantly different. Although there were only a small number of patients who met the criteria for this pilot study, a strong association was found between swallowing dysfunction and aspiration pneumonia. JF - Dysphagia AU - Martin, B J AU - Corlew, M M AU - Wood, H AU - Olson, D AU - Golopol, L A AU - Wingo, M AU - Kirmani, N AD - Celement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI. PY - 1994 SP - 1 EP - 6 VL - 9 IS - 1 SN - 0179-051X, 0179-051X UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85156179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dysphagia&rft.atitle=The+association+of+swallowing+dysfunction+and+aspiration+pneumonia.&rft.au=Martin%2C+B+J%3BCorlew%2C+M+M%3BWood%2C+H%3BOlson%2C+D%3BGolopol%2C+L+A%3BWingo%2C+M%3BKirmani%2C+N&rft.aulast=Martin&rft.aufirst=B&rft.date=1994-01-01&rft.volume=9&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Dysphagia&rft.issn=0179051X&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Assessing depression in alcoholics with the BDI, SCL-90R, and DIS criteria. AN - 77811282; 7703706 AB - Depression was assessed in a sample of alcohol-dependent inpatients using the Beck Depression Inventory (BDI), Diagnostic Interview Schedule (DIS), and the SCL-90R. Initially, comparisons were made regarding the prevalence of depression among the three scales, and then regarding the relationship of each depression scale to symptoms of alcohol dependence and amount of drinking. Subjects were 59 inpatients enrolled in an alcohol-dependence treatment program at a university-affiliated health center. The prevalence of depression in the sample ranged from 20% with the DIS criteria to 42% with the SCL-90R. The relationship of depression to measures of alcohol dependence varied, depending upon the scale. Symptoms of alcohol dependence did not differ between depressed and nondepressed subjects using the DIS current or lifetime diagnosis, but symptoms of alcohol dependence were greater among those subjects considered depressed according to the other scales. Possible reasons for such differences are discussed, as are both clinical and research considerations. JF - Journal of substance abuse AU - Choquette, K A AD - Alcohol and Family Studies Laboratory, Brockton/West Roxbury Veterans Administration Medical Center, MA 02401. Y1 - 1994 PY - 1994 DA - 1994 SP - 295 EP - 304 VL - 6 IS - 3 SN - 0899-3289, 0899-3289 KW - Index Medicus KW - Reproducibility of Results KW - Humans KW - Adult KW - Middle Aged KW - Psychometrics KW - Male KW - Female KW - Comorbidity KW - Personality Inventory -- statistics & numerical data KW - Personality Assessment -- statistics & numerical data KW - Depressive Disorder -- psychology KW - Depressive Disorder -- diagnosis KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77811282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse&rft.atitle=Assessing+depression+in+alcoholics+with+the+BDI%2C+SCL-90R%2C+and+DIS+criteria.&rft.au=Choquette%2C+K+A&rft.aulast=Choquette&rft.aufirst=K&rft.date=1994-01-01&rft.volume=6&rft.issue=3&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse&rft.issn=08993289&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-05-09 N1 - Date created - 1995-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thrombin-induced alterations in endothelial cell cytoarchitectural and functional properties. AN - 77795149; 7899871 AB - alpha-Thrombin interacts with confluent bovine pulmonary artery endothelial cells to produce two types of actin microfilament rearrangements: (1) The loss of cortical actin correlates with interruption of barrier integrity, evident from increased permeability to 125I-albumin; and (2) an increase in actin stress fibers results in greater adherence of the cells to their extracellular substrate. Use of phallatoxin compounds that stabilize actin filaments and prevent their depolymerization prevents both the cytoarchitectural and functional changes resulting from thrombin challenge. JF - Seminars in thrombosis and hemostasis AU - Phillips, P G AD - Research Service, Stratton Veterans Administration Medical Center, Albany, NY 12208. Y1 - 1994 PY - 1994 DA - 1994 SP - 417 EP - 425 VL - 20 IS - 4 SN - 0094-6176, 0094-6176 KW - Actins KW - 0 KW - Amanitins KW - Fluorescent Dyes KW - Peptides, Cyclic KW - phallacidin KW - 26645-35-2 KW - 7-nitrobenz-2-oxa-1,3-diazole-phallacidin KW - 73413-78-2 KW - Thrombin KW - EC 3.4.21.5 KW - Index Medicus KW - Microscopy, Fluorescence KW - Animals KW - Cattle KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Actins -- ultrastructure KW - Cell Division -- drug effects KW - Amanitins -- metabolism KW - Actins -- drug effects KW - Cell Adhesion -- drug effects KW - Peptides, Cyclic -- pharmacology KW - Endothelium, Vascular -- drug effects KW - Thrombin -- pharmacology KW - Endothelium, Vascular -- ultrastructure KW - Endothelium, Vascular -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77795149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+thrombosis+and+hemostasis&rft.atitle=Thrombin-induced+alterations+in+endothelial+cell+cytoarchitectural+and+functional+properties.&rft.au=Phillips%2C+P+G&rft.aulast=Phillips&rft.aufirst=P&rft.date=1994-01-01&rft.volume=20&rft.issue=4&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Seminars+in+thrombosis+and+hemostasis&rft.issn=00946176&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-04-27 N1 - Date created - 1995-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Memory and forgetting: long-term and gradual changes in memory storage. AN - 77761726; 7883480 JF - International review of neurobiology AU - Squire, L R AD - Veterans Administration Medical Center, San Diego, California 92161. Y1 - 1994 PY - 1994 DA - 1994 SP - 243 EP - 69; discussion 285-8 VL - 37 SN - 0074-7742, 0074-7742 KW - Index Medicus KW - Learning KW - Brain Injuries -- physiopathology KW - Humans KW - Brain Injuries -- psychology KW - Alcohol Amnestic Disorder -- physiopathology KW - Hippocampus -- physiopathology KW - Alcohol Amnestic Disorder -- psychology KW - Brain -- physiopathology KW - Models, Psychological KW - Memory KW - Amnesia, Retrograde -- physiopathology KW - Models, Neurological KW - Brain -- physiology KW - Amnesia, Retrograde -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77761726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+review+of+neurobiology&rft.atitle=Memory+and+forgetting%3A+long-term+and+gradual+changes+in+memory+storage.&rft.au=Squire%2C+L+R&rft.aulast=Squire&rft.aufirst=L&rft.date=1994-01-01&rft.volume=37&rft.issue=&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=International+review+of+neurobiology&rft.issn=00747742&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-04-12 N1 - Date created - 1995-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cytotoxic effects of alpha- and gamma-interferon and tumor necrosis factor in human bladder tumor cell lines. AN - 77748683; 7871638 AB - We investigated the activity of alpha-interferon (alpha-IFN), gamma-interferon (gamma-IFN) and tumor necrosis factor-alpha (TNF-alpha) in a panel of ten human bladder tumor cell lines. All cytokines were tested at concentrations of 100-10,000 U/ml in a clonogenic assay system. We found that alpha-IFN was active against five of the ten lines while gamma-IFN was only active against one line. TNF was active against five of the ten lines. Maximum synergisms were obtained between the alpha-IFN and TNF, occurring in nine of the ten cell lines. We conclude that alpha-IFN and TNF are active as single agents and synergistic when used together in vitro in human bladder tumor cell lines. JF - Urological research AU - Niell, H B AU - Mauer, A M AU - Rademacher, D AD - Research Service at the Veterans-Administration Medical Center, Memphis, TN 38163. Y1 - 1994 PY - 1994 DA - 1994 SP - 247 EP - 250 VL - 22 IS - 4 SN - 0300-5623, 0300-5623 KW - Drug Combinations KW - 0 KW - Immunologic Factors KW - Interferon Type I KW - Recombinant Proteins KW - Tumor Necrosis Factor-alpha KW - Interferon-gamma KW - 82115-62-6 KW - Index Medicus KW - Tumor Cells, Cultured KW - Cell Survival -- drug effects KW - Humans KW - Urinary Bladder Neoplasms KW - Cell Division -- drug effects KW - Drug Synergism KW - Urinary Bladder -- pathology KW - Tumor Necrosis Factor-alpha -- toxicity KW - Interferon-gamma -- toxicity KW - Interferon Type I -- toxicity KW - Urinary Bladder -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77748683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urological+research&rft.atitle=Cytotoxic+effects+of+alpha-+and+gamma-interferon+and+tumor+necrosis+factor+in+human+bladder+tumor+cell+lines.&rft.au=Niell%2C+H+B%3BMauer%2C+A+M%3BRademacher%2C+D&rft.aulast=Niell&rft.aufirst=H&rft.date=1994-01-01&rft.volume=22&rft.issue=4&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Urological+research&rft.issn=03005623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-03-27 N1 - Date created - 1995-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparative neuropsychological approach to alcoholism and the brain. AN - 77136184; 8974348 AB - Comparative neuropsychology involves the study of brain-behavior relationships by applying experimental paradigms, used extensively in animal laboratories, for testing human clinical populations. Popular paradigms include delayed reaction tasks, discrimination and reversal learning tasks, and matching- and nonmatching-to-sample. Such tasks were perfected on experimental animals having well defined brain lesions, and adapted for the sensory and motor capabilities of human neurological patients. By holding task requirements constant for human and nonhuman primates, analogous measures can be made of neurobehavioral deficits associated with specific brain damage. Human and nonhuman primates solve many so-called animal-learning tasks, in similar ways. Moreover, many tasks, despite their apparent simplicity, already have proven to be sensitive to cognitive impairments after brain damage in humans and nonhumans alike. An important advantage of using paradigms from comparative neuropsychology, in conjunction with standard clinical neuropsychological assessments, is that the simplicity of the tasks makes them manageable for patients with severe cognitive impairments. In addition, since the tasks do not require linguistic strategies for performance, the problems can be solved by patients whose language skills are compromised. An example of the application of comparative neuropsychology to clinical populations is given: patients with a history of long term alcohol abuse were tested on delayed reaction paradigms, and the findings have been useful in clarifying the contribution of damaged frontal cortical-subcortical brains systems to their cognitive impairments. JF - Alcohol and alcoholism (Oxford, Oxfordshire). Supplement AU - Oscar-Berman, M AD - U.S. Department of Veterans Affairs, Boston, MA, USA. Y1 - 1994 PY - 1994 DA - 1994 SP - 281 EP - 289 VL - 2 SN - 1358-6173, 1358-6173 KW - Index Medicus KW - History of medicine KW - Animals KW - History, 20th Century KW - Brain Injuries -- physiopathology KW - Humans KW - Brain Injuries -- psychology KW - Neuropsychology -- history KW - Brain Injuries -- etiology KW - Primates KW - Brain -- physiopathology KW - Alcoholism -- physiopathology KW - Alcoholism -- psychology KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77136184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.atitle=A+comparative+neuropsychological+approach+to+alcoholism+and+the+brain.&rft.au=Oscar-Berman%2C+M&rft.aulast=Oscar-Berman&rft.aufirst=M&rft.date=1994-01-01&rft.volume=2&rft.issue=&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29.+Supplement&rft.issn=13586173&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-04-07 N1 - Date created - 1997-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clonazepam-related sexual dysfunction in male veterans with PTSD. AN - 77134832; 9160580 AB - Medication-induced sexual dysfunction can significantly interfere with patients' quality of life and lead to poor compliance. This retrospective study examined the records of 100 male veterans with post-traumatic stress disorder (PTSD) selected in alphabetical order from an active treatment file of 230 patients. Forty-two patients had received clonazepam (mean maximum dose: 3.4 +/- 1.6 mg/day) at some point during their treatment. Of these, 18 (42.9%) complained of significant sexual dysfunction (primarily erectile dysfunction). Eighty-four patients received diazepam (mean maximum dose: 52.1 +/- 29.7 mg/day), nine received alprazolam (mean maximum dose: 5.2 +/- 2.8 mg/day) and eight received lorazepam (mean maximum dose: 3.8 +/- 2.4 mg/day). None of these patients complained of sexual dysfunction during treatment with these three other benzodiazepines. Our findings suggest that benzodiazepines, particularly clonazepam in the current study, can be a cause of sexual dysfunction in many male patients. Prospective studies comparing the overall clinical utility of various benzodiazepines are indicated in this and other clinic populations. JF - Anxiety AU - Fossey, M D AU - Hamner, M B AD - Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC 29401, USA. PY - 1994 SP - 233 EP - 236 VL - 1 IS - 5 SN - 1070-9797, 1070-9797 KW - GABA Modulators KW - 0 KW - Clonazepam KW - 5PE9FDE8GB KW - Lorazepam KW - O26FZP769L KW - Diazepam KW - Q3JTX2Q7TU KW - Alprazolam KW - YU55MQ3IZY KW - Index Medicus KW - Diazepam -- therapeutic use KW - Diazepam -- adverse effects KW - Alprazolam -- therapeutic use KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Retrospective Studies KW - Middle Aged KW - Lorazepam -- therapeutic use KW - Alprazolam -- adverse effects KW - Male KW - Lorazepam -- adverse effects KW - Erectile Dysfunction -- chemically induced KW - GABA Modulators -- therapeutic use KW - Combat Disorders -- psychology KW - Clonazepam -- adverse effects KW - Erectile Dysfunction -- psychology KW - Combat Disorders -- drug therapy KW - GABA Modulators -- adverse effects KW - Veterans -- psychology KW - Combat Disorders -- diagnosis KW - Erectile Dysfunction -- diagnosis KW - Clonazepam -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77134832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anxiety&rft.atitle=Clonazepam-related+sexual+dysfunction+in+male+veterans+with+PTSD.&rft.au=Fossey%2C+M+D%3BHamner%2C+M+B&rft.aulast=Fossey&rft.aufirst=M&rft.date=1994-01-01&rft.volume=1&rft.issue=5&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Anxiety&rft.issn=10709797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1997-06-18 N1 - Date created - 1997-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of cytokines tumor necrosis factor alpha and interleukin 1 beta on endotoxin-mediated inhibition of endothelium-derived relaxing factor bioactivity and nitric oxide production in vascular endothelium. AN - 77087729; 7743332 AB - Endotoxemia results in the release of cytokines that exert complex effects on the cardiovascular system. The purpose of this study was to 1) determine if interleukin 1 beta (IL1 beta) and tumor necrosis factor alpha (TNF alpha) elicit the release of endothelium-derived relaxing factor (EDRF) and nitric oxide derived from the constitutive nitric oxide synthase present in vascular endothelium, and 2) determine if these cytokines alter endotoxin-mediated decreases in EDRF bioactivity and nitric oxide production. Cultured bovine aortic endothelial cells were directly exposed to endotoxin, human recombinant TNF alpha, interleukin 1 beta, or a combination of endotoxin and cytokine for 1 h, followed by a second hour without endotoxin. Subsequently, both basal as well as agonist-stimulated (bradykinin) EDRF bioactivity and nitric oxide (NO) content of the effluent were quantitated. In additional experiments, endothelial cells were exposed acutely over a 30-min assay period to either endotoxin alone, cytokine alone, or endotoxin and cytokine. Following the 2-h incubation, endotoxin alone markedly reduced basal EDRF bioactivity and NO production (44 +/- 13% control, 66 +/- 13% control, respectively) and decreased bradykinin-stimulated EDRF bioactivity and NO production (58 +/- 5% control, 55 +/- 4% control, respectively). TNF alpha and IL1 beta did not stimulate EDRF release or NO production either acutely or after prolonged exposure, nor did they alter agonist-stimulated EDRF bioactivity and NO production. Similarly co-incubation of endotoxin with TNF alpha or IL1 beta failed to significantly alter the inhibitory effects of endotoxin on EDRF bioactivity and NO production.(ABSTRACT TRUNCATED AT 250 WORDS) JF - Shock (Augusta, Ga.) AU - Myers, P R AU - Parker, J L AU - Tanner, M A AU - Adams, H R AD - Department of Medicine, College of Medicine, Harry S. Truman Memorial Veterans Administration Hospital, Columbia, Missouri, USA. Y1 - 1994/01// PY - 1994 DA - January 1994 SP - 73 EP - 78 VL - 1 IS - 1 SN - 1073-2322, 1073-2322 KW - Endotoxins KW - 0 KW - Interleukin-1 KW - Recombinant Proteins KW - Tumor Necrosis Factor-alpha KW - Nitric Oxide KW - 31C4KY9ESH KW - Bradykinin KW - S8TIM42R2W KW - Index Medicus KW - Shock, Septic -- complications KW - Animals KW - Cattle KW - Recombinant Proteins -- pharmacology KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Cells, Cultured KW - Humans KW - Hypotension -- etiology KW - Bradykinin -- pharmacology KW - Hypotension -- metabolism KW - Shock, Septic -- metabolism KW - Interleukin-1 -- pharmacology KW - Nitric Oxide -- antagonists & inhibitors KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Nitric Oxide -- biosynthesis KW - Endotoxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/77087729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Shock+%28Augusta%2C+Ga.%29&rft.atitle=Effects+of+cytokines+tumor+necrosis+factor+alpha+and+interleukin+1+beta+on+endotoxin-mediated+inhibition+of+endothelium-derived+relaxing+factor+bioactivity+and+nitric+oxide+production+in+vascular+endothelium.&rft.au=Myers%2C+P+R%3BParker%2C+J+L%3BTanner%2C+M+A%3BAdams%2C+H+R&rft.aulast=Myers&rft.aufirst=P&rft.date=1994-01-01&rft.volume=1&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Shock+%28Augusta%2C+Ga.%29&rft.issn=10732322&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1995-06-15 N1 - Date created - 1995-06-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Peripheral T-cell lymphoma of the scrotum. AN - 76573395; 8023648 AB - Primary lymphoma of the scrotum is rare. We report a case of primary immunoblastic lymphoma of the scrotum in a homosexual who was negative for antibodies to human immunodeficiency virus. Immunoperoxidase stains of paraffin-embedded tissue were consistent with a T-cell phenotype. Although complete remission was initially induced with surgical extirpation of the tumor and combination chemotherapy, isolated skin relapse developed which again responded to chemotherapy. JF - Acta haematologica AU - Doll, D C AU - Diaz-Arias, A A AD - Department of Medicine, Veterans Administration Hospital, Columbia, Mo 65201. Y1 - 1994 PY - 1994 DA - 1994 SP - 77 EP - 79 VL - 91 IS - 2 SN - 0001-5792, 0001-5792 KW - Vincristine KW - 5J49Q6B70F KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - AIDS/HIV KW - Cyclophosphamide -- administration & dosage KW - Humans KW - Vincristine -- administration & dosage KW - Hand KW - Doxorubicin -- administration & dosage KW - Neoplasms, Second Primary -- pathology KW - Middle Aged KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Chemotherapy, Adjuvant KW - Immunoenzyme Techniques KW - Male KW - Prednisone -- administration & dosage KW - Remission Induction KW - Genital Neoplasms, Male -- pathology KW - Skin Neoplasms -- surgery KW - Scrotum -- pathology KW - Genital Neoplasms, Male -- surgery KW - Lymphoma, T-Cell, Peripheral -- surgery KW - Lymphoma, T-Cell, Peripheral -- pathology KW - Skin Neoplasms -- pathology KW - Scrotum -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76573395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+haematologica&rft.atitle=Peripheral+T-cell+lymphoma+of+the+scrotum.&rft.au=Doll%2C+D+C%3BDiaz-Arias%2C+A+A&rft.aulast=Doll&rft.aufirst=D&rft.date=1994-01-01&rft.volume=91&rft.issue=2&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Acta+haematologica&rft.issn=00015792&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-08-04 N1 - Date created - 1994-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Class III antiarrhythmic drugs. AN - 76517339; 8199363 AB - Pharmacological therapy of cardiac arrhythmias continues to evolve, with an increasing shift from class I to class III compounds and beta-blockers. This is engendered by increasing concern that class I antiarrhythmic drugs might adversely affect mortality in patients with significant structural heart disease. The focus now is on complex molecules such as amiodarone and sotalol, as well as D-sotalol and structurally diverse newer class III agents (such as dofetilide, MK-499, ibutilide, almokalant, and MS-551 among many others), which act only by increasing the time course of myocardial repolarization. In the development of newer drugs, the main endpoint in clinical trials is also beginning to shift to mortality from surrogate endpoints such as those determined by Holter monitoring and programmed electrical stimulation. The advent of implantable devices allows the performance of clinical trials with a mortality endpoint in patients with manifest ventricular tachycardia and fibrillation while providing an alternative mode of therapy for these arrhythmias. In the case of manifest ventricular tachycardia and fibrillation and aborted sudden death, adequately designed, controlled trials can now be undertaken by the use of implantable devices. In such trials, implantable cardioverter-defibrillators may serve in lieu of the placebo arm of a randomized trial. Trials involving a comparison of implantable cardioverter-defibrillators and best medical therapy (for the present, amiodarone and sotalol) are currently in progress. To what extent the newer class III agents will meet the requirements of an ideal antifibrillatory agent that reduces mortality in patients with structural heart disease remains a continuing investigative challenge. JF - Current opinion in cardiology AU - Singh, B N AU - Ahmed, R AD - Section of Cardiology, Veterans Administration Medical Center, West Los Angeles, CA 90073. Y1 - 1994/01// PY - 1994 DA - January 1994 SP - 12 EP - 22 VL - 9 IS - 1 SN - 0268-4705, 0268-4705 KW - Anti-Arrhythmia Agents KW - 0 KW - Sotalol KW - A6D97U294I KW - Amiodarone KW - N3RQ532IUT KW - Index Medicus KW - Tachycardia, Ventricular -- mortality KW - Sotalol -- therapeutic use KW - Humans KW - Ventricular Fibrillation -- drug therapy KW - Amiodarone -- therapeutic use KW - Clinical Trials as Topic KW - Heart Conduction System -- physiopathology KW - Amiodarone -- adverse effects KW - Ventricular Fibrillation -- mortality KW - Tachycardia, Ventricular -- physiopathology KW - Tachycardia, Ventricular -- drug therapy KW - Survival Rate KW - Heart Conduction System -- drug effects KW - Ventricular Fibrillation -- physiopathology KW - Sotalol -- adverse effects KW - Electrocardiography -- drug effects KW - Arrhythmias, Cardiac -- mortality KW - Arrhythmias, Cardiac -- drug therapy KW - Arrhythmias, Cardiac -- physiopathology KW - Anti-Arrhythmia Agents -- adverse effects KW - Anti-Arrhythmia Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76517339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+cardiology&rft.atitle=Class+III+antiarrhythmic+drugs.&rft.au=Singh%2C+B+N%3BAhmed%2C+R&rft.aulast=Singh&rft.aufirst=B&rft.date=1994-01-01&rft.volume=9&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+cardiology&rft.issn=02684705&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-07-06 N1 - Date created - 1994-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - New protocols for perioperative management of podiatric patients taking oral anticoagulants. AN - 76448913; 8161987 AB - This article introduces new protocols for surgical intervention on patients who are taking oral anticoagulants. The authors review various drug interactions that can suppress the action of oral anticoagulants. Complications of oral anticoagulation therapy are presented, including "purple toe syndrome." JF - The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons AU - Lanzat, M AU - Danna, A T AU - Jacobson, D S AD - Podiatric Section, Veterans Administration Medical Center, West Los Angeles, California. PY - 1994 SP - 16 EP - 20 VL - 33 IS - 1 SN - 1067-2516, 1067-2516 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Anticoagulants KW - Warfarin KW - 5Q7ZVV76EI KW - Index Medicus KW - Administration, Oral KW - Risk KW - Drug Interactions KW - Humans KW - Hemostasis KW - Warfarin -- adverse effects KW - Warfarin -- administration & dosage KW - Thromboembolism -- prevention & control KW - Warfarin -- pharmacology KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology KW - Anticoagulants -- adverse effects KW - Anticoagulants -- pharmacology KW - Foot Diseases -- surgery KW - Anticoagulants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76448913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+foot+and+ankle+surgery+%3A+official+publication+of+the+American+College+of+Foot+and+Ankle+Surgeons&rft.atitle=New+protocols+for+perioperative+management+of+podiatric+patients+taking+oral+anticoagulants.&rft.au=Lanzat%2C+M%3BDanna%2C+A+T%3BJacobson%2C+D+S&rft.aulast=Lanzat&rft.aufirst=M&rft.date=1994-01-01&rft.volume=33&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+foot+and+ankle+surgery+%3A+official+publication+of+the+American+College+of+Foot+and+Ankle+Surgeons&rft.issn=10672516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-05-25 N1 - Date created - 1994-05-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Foot Ankle Surg. 1994 Sep-Oct;33(5):526 [7849681] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Radiolabeled antibody imaging of patients with potentially resectable colorectal adenocarcinoma. AN - 76392331; 8131088 AB - Thirty-two patients with potentially resectable recurrent colorectal adenocarcinoma were imaged with the radioimmunoconjugate 111In-satumomab pendetide to determine whether imaging supplies clinically relevant information relating to the extent of disease in patients with different presenting characteristics. Patients included 12 with increasing carcinoembryonic antigen (CEA) without anatomical evidence of recurrence, 13 with radiological abnormalities consistent with apparently isolated metastases, and 7 with recurrence and anatomical abnormalities of unclear significance. 111In-satumomab pendetide imaging detected extrahepatic abdominal and pelvic disease in 16 subjects. Imaging was most informative in patients with recurrent disease and anatomical abnormalities of unclear significance, but imaging of the liver was suboptimal owing to high levels of nonspecific uptake. We conclude 111In-satumomab pendetide imaging can supply clinically relevant information relating to the extent and location of recurrent colorectal adenocarcinoma in patients with extrahepatic abdominal and pelvic radiological abnormalities of unclear significance and in radiologically normal patients with high CEA levels. JF - Cancer investigation AU - Weiner, G J AU - Kahn, D AU - Jochimsen, P R AU - Bevering, C G AU - Kisker, M A AD - Department of Internal Medicine, Iowa City Veterans Administration, Iowa. Y1 - 1994 PY - 1994 DA - 1994 SP - 111 EP - 120 VL - 12 IS - 2 SN - 0735-7907, 0735-7907 KW - Antibodies, Monoclonal KW - 0 KW - Carcinoembryonic Antigen KW - Immunotoxins KW - Indium Radioisotopes KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Carcinoembryonic Antigen -- blood KW - Male KW - Female KW - Colorectal Neoplasms -- diagnostic imaging KW - Radioimmunodetection -- methods KW - Colorectal Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76392331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+investigation&rft.atitle=Radiolabeled+antibody+imaging+of+patients+with+potentially+resectable+colorectal+adenocarcinoma.&rft.au=Weiner%2C+G+J%3BKahn%2C+D%3BJochimsen%2C+P+R%3BBevering%2C+C+G%3BKisker%2C+M+A&rft.aulast=Weiner&rft.aufirst=G&rft.date=1994-01-01&rft.volume=12&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Cancer+investigation&rft.issn=07357907&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-04-21 N1 - Date created - 1994-04-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phosphoramidon augments contraction of guinea pig tracheal smooth muscle induced by histamine and leukotriene-D4. AN - 76360232; 8111247 AB - Our previous studies have shown that the inhibition of neutral endopeptidase, an enzyme which degrades tachykinins, increases anaphylactic contraction of guinea pig tracheal smooth muscle. Anaphylactic release of tachykinin-like substances was indicated. To investigate this observation further, we examined the effects of phosphoramidon, an inhibitor of a neutral endopeptidase, on contraction induced by mediators of anaphylaxis. Phosphoramidon significantly increased histamine- and leukotriene D4-induced contractions of tracheal rings from unsensitized animals (by 14 and 48%, respectively), but failed to alter the contractile responses to prostaglandins D2 and F2 alpha. In tracheal rings preincubated with tachykinin antagonist-[D-Pro4, D-Trp7,9]-substance P(4-11), or in capsaicin-desensitized tracheal rings, phosphoramidon did not change histamine- and leukotriene D4-induced contractions. In the second part of the study, performed on tracheal rings obtained from ovalbumin-sensitized guinea pigs, we examined the effects of phosphoramidon on contractile responses to histamine and leukotrienes which are released after antigen challenge. The incubation of tracheal rings with H1-histamine receptor antagonist (diphenhydramine HCl) or leukotriene receptor antagonist (ICI 198.615) prevented a phosphoramidon-dependent increase of antigen-induced contraction. These results indicate that histamine and leukotrienes may be involved in the anaphylactic release of tachykinin-like substances or other neutral endopeptidase substratum. JF - International archives of allergy and immunology AU - Tudorić, N AU - Coon, R L AU - Bosnjak, Z J AD - Department of Anesthesiology, Zablocki Veterans Administration Medical Center, Milwaukee, Wisc. Y1 - 1994 PY - 1994 DA - 1994 SP - 286 EP - 292 VL - 103 IS - 3 SN - 1018-2438, 1018-2438 KW - Antigens KW - 0 KW - Glycopeptides KW - Indazoles KW - SRS-A KW - ICI 198615 KW - 104448-53-5 KW - Leukotriene D4 KW - 73836-78-9 KW - Histamine KW - 820484N8I3 KW - Diphenhydramine KW - 8GTS82S83M KW - Dinoprost KW - B7IN85G1HY KW - Neprilysin KW - EC 3.4.24.11 KW - Prostaglandin D2 KW - RXY07S6CZ2 KW - phosphoramidon KW - T3G94E2LB1 KW - Index Medicus KW - SRS-A -- antagonists & inhibitors KW - Animals KW - Leukotriene D4 -- pharmacology KW - Guinea Pigs KW - Dinoprost -- pharmacology KW - Indazoles -- pharmacology KW - Trachea -- physiology KW - Antigens -- pharmacology KW - Prostaglandin D2 -- pharmacology KW - Anaphylaxis -- chemically induced KW - Histamine -- pharmacology KW - Diphenhydramine -- pharmacology KW - In Vitro Techniques KW - Muscle Contraction -- drug effects KW - Muscle, Smooth -- physiology KW - Glycopeptides -- pharmacology KW - Neprilysin -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76360232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+archives+of+allergy+and+immunology&rft.atitle=Phosphoramidon+augments+contraction+of+guinea+pig+tracheal+smooth+muscle+induced+by+histamine+and+leukotriene-D4.&rft.au=Tudori%C4%87%2C+N%3BCoon%2C+R+L%3BBosnjak%2C+Z+J&rft.aulast=Tudori%C4%87&rft.aufirst=N&rft.date=1994-01-01&rft.volume=103&rft.issue=3&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=International+archives+of+allergy+and+immunology&rft.issn=10182438&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-03-31 N1 - Date created - 1994-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Elevated levels of glucose and L-fucose reduce 22Na+ uptake and whole cell Na+ current in cultured neuroblastoma cells. AN - 76324330; 8263545 AB - Na+ flux was studied in cultured neuroblastoma cells grown in medium containing increased glucose or L-fucose concentrations. Chronic exposure of neuroblastoma cells to 30 mM glucose or 30 mM L-fucose caused a decrease in ouabain-sensitive and veratridine-stimulated 22Na+ uptake compared with cells cultured in unsupplemented medium. The Na+ current, determined by using whole-cell configuration of the patch clamp, was also decreased in these cells. Tetrodotoxin (3 microM), which blocked whole cell Na+ currents, also blocked veratridine-stimulated 22Na+ accumulation. Culturing cells in medium containing 30 mM fructose as an osmotic control had no effect on Na+ flux. Specific [3H]saxitoxin binding was not affected by 30 mM glucose or 30 mM L-fucose compared with cells grown in unsupplemented medium, suggesting that the number of Na+ channels was not decreased. These studies suggest that exposing cultured neuronal cells to conditions that occur in the diabetic milieu alters Na+ transport and Na(+)-channel activity. JF - Journal of neurochemistry AU - Yorek, M A AU - Stefani, M R AU - Wachtel, R E AD - Veterans Administration Medical Center, Department of Internal Medicine, Iowa City, IA 52246. Y1 - 1994/01// PY - 1994 DA - January 1994 SP - 63 EP - 69 VL - 62 IS - 1 SN - 0022-3042, 0022-3042 KW - Sodium Channels KW - 0 KW - Sodium Radioisotopes KW - Saxitoxin KW - 35523-89-8 KW - Fucose KW - 3713-31-3 KW - Ouabain KW - 5ACL011P69 KW - Veratridine KW - 71-62-5 KW - Sodium KW - 9NEZ333N27 KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Animals KW - Tumor Cells, Cultured KW - Kinetics KW - Mice KW - Membrane Potentials -- drug effects KW - Electric Stimulation KW - Veratridine -- pharmacology KW - Ouabain -- pharmacology KW - Saxitoxin -- metabolism KW - Cell Line KW - Cell Division KW - Glucose -- pharmacology KW - Fucose -- pharmacology KW - Sodium Channels -- physiology KW - Sodium Channels -- metabolism KW - Sodium Channels -- drug effects KW - Neuroblastoma -- metabolism KW - Sodium -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76324330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Elevated+levels+of+glucose+and+L-fucose+reduce+22Na%2B+uptake+and+whole+cell+Na%2B+current+in+cultured+neuroblastoma+cells.&rft.au=Yorek%2C+M+A%3BStefani%2C+M+R%3BWachtel%2C+R+E&rft.aulast=Yorek&rft.aufirst=M&rft.date=1994-01-01&rft.volume=62&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-01-24 N1 - Date created - 1994-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Service Utilization and Minority Elderly: Appropriateness, Accessibility and Acceptability AN - 61631010; 199501006 AB - Based on a review of research, patterns of utilization of emergency & community-based services, hospital stays, physician visits, & nursing home placements among minority elderly are described. Although ethnic elders have higher service needs based on medical problems & functional limitations, they have lower utilization rates of the services most important for geriatric populations. Structural & cultural barriers to service utilization are discussed. A framework for appropriate, accessible, & acceptable geriatric care provision for minority elders is presented. 3 Figures, 61 References. Adapted from the source document. JF - Gerontology & Geriatrics Education AU - Damron-Rodriguez, JoAnn AU - Wallace, Steven AU - Kington, Raynard AD - Geriatric Research/Education/Clinical Center West Los Angeles Veterans Administration Medical Center, Wilshire & Sawtelle Blvds CA 90024 Y1 - 1994///0, PY - 1994 DA - 0, 1994 SP - 45 EP - 63 VL - 15 IS - 1 SN - 0270-1960, 0270-1960 KW - service utilization patterns, minority elderly KW - research review KW - Minority Groups KW - Hospitalization KW - Health Problems KW - Elderly KW - Community Services KW - Nursing Homes KW - Health Care Utilization KW - article KW - 6127: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61631010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gerontology+%26+Geriatrics+Education&rft.atitle=Service+Utilization+and+Minority+Elderly%3A+Appropriateness%2C+Accessibility+and+Acceptability&rft.au=Damron-Rodriguez%2C+JoAnn%3BWallace%2C+Steven%3BKington%2C+Raynard&rft.aulast=Damron-Rodriguez&rft.aufirst=JoAnn&rft.date=1994-01-01&rft.volume=15&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Gerontology+%26+Geriatrics+Education&rft.issn=02701960&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Minority Groups; Elderly; Health Care Utilization; Hospitalization; Nursing Homes; Community Services; Health Problems ER - TY - JOUR T1 - A Model Curriculum for Tobacco Use Cessation and Prevention Intervention AN - 61616938; 199501522 AB - If oral health care providers are to play a more aggressive role in tobacco intervention, a tobacco-related curriculum must become institutionalized in dental schools across the nation. Outlined here are the goals, objective, & core content of a tobacco-related curriculum that could be presented in approximately eight hours. The curriculum presents a rationale for provider involvement & discusses the prevalence of tobacco use, the major health effects of tobacco use, the benefits & processes of cessation, appropriate strategies for intervention, & social policy issues. Implementation issues are also considered. 2 Figures, 4 References. M. Maguire JF - Health Values AU - Geboy, Michael J AU - Fried, Jacquelyn L AD - Veterans Administration Medical Center, 500 Highway 89 Prescott AZ 86313 Y1 - 1994/01// PY - 1994 DA - January 1994 SP - 96 EP - 101 VL - 18 IS - 1 SN - 0147-0353, 0147-0353 KW - tobacco-related curriculum, dental schools, goals/objective/content KW - Smoking KW - Curriculum KW - Dental Students KW - Intervention KW - article KW - 6122: social welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61616938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Values&rft.atitle=A+Model+Curriculum+for+Tobacco+Use+Cessation+and+Prevention+Intervention&rft.au=Geboy%2C+Michael+J%3BFried%2C+Jacquelyn+L&rft.aulast=Geboy&rft.aufirst=Michael&rft.date=1994-01-01&rft.volume=18&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Health+Values&rft.issn=01470353&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Smoking; Dental Students; Curriculum; Intervention ER - TY - JOUR T1 - Family Influences on the Course of Chronic Illness: A Cognitive-Behavioral Transactional Model AN - 61370803; 9501499 AB - Describes an integrative cognitive-behavioral transactional model of family functioning that informs research on the influence of the family on the course of chronic disease. A rapidly evolving literature in the area of chronic pain is offered as an example of work based in part on this model. Suggestions for generalization of the model across the chronic illness domain are made. 46 References. Adapted from the source document. JF - Annals of Behavioral Medicine AU - Kerns, Robert D AU - Weiss, Laura H AD - Psychology Service Veterans Administration Medical Center, 950 Campbell Ave West Haven CT 06516 Y1 - 1994///0, PY - 1994 DA - 0, 1994 SP - 116 EP - 121 VL - 16 IS - 2 SN - 0883-6612, 0883-6612 KW - chronic disease course, family influences, cognitive-behavioral transactional research model KW - Chronic Illness KW - Psychosocial Factors KW - Family Life KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61370803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Behavioral+Medicine&rft.atitle=Family+Influences+on+the+Course+of+Chronic+Illness%3A+A+Cognitive-Behavioral+Transactional+Model&rft.au=Kerns%2C+Robert+D%3BWeiss%2C+Laura+H&rft.aulast=Kerns&rft.aufirst=Robert&rft.date=1994-01-01&rft.volume=16&rft.issue=2&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Annals+of+Behavioral+Medicine&rft.issn=08836612&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ABMEEH N1 - SubjectsTermNotLitGenreText - Chronic Illness; Family Life; Psychosocial Factors ER - TY - JOUR T1 - Families and Health: The Negative Side of Social Ties AN - 61369455; 9501473 AB - Argues that the supportive & nonsupportive aspects of social relations need to be considered to understand the influence of family & other social ties on health. An examination of the literature illustrates how social support, particularly in the form of family ties, may increase risk for negative rather than positive health outcomes. A framework for research is provided. 117 References. Adapted from the source document. JF - Annals of Behavioral Medicine AU - Burg, Matthew M AU - Seeman, Teresa E AD - Health Psychology Section Veterans Administration Medical Center, 950 Campbell Ave West Haven CT 06516 Y1 - 1994///0, PY - 1994 DA - 0, 1994 SP - 109 EP - 115 VL - 16 IS - 2 SN - 0883-6612, 0883-6612 KW - health, family/social support impacts KW - literature review KW - Family Relations KW - Social Relations KW - Health Problems KW - Family Life KW - Illness KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61369455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Behavioral+Medicine&rft.atitle=Families+and+Health%3A+The+Negative+Side+of+Social+Ties&rft.au=Burg%2C+Matthew+M%3BSeeman%2C+Teresa+E&rft.aulast=Burg&rft.aufirst=Matthew&rft.date=1994-01-01&rft.volume=16&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Annals+of+Behavioral+Medicine&rft.issn=08836612&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ABMEEH N1 - SubjectsTermNotLitGenreText - Illness; Family Relations; Family Life; Health Problems; Social Relations ER - TY - JOUR T1 - Neuroimaging Studies of Cerebral "visceral Larva Migrans" Syndrome AN - 1785253288; PQ0002901864 AB - "Visceral larva migrans" syndrome is a zoonotic disease caused by the migration or presence in human tissue of nematode larva from lower-order animals. This syndrome includes generalized illness. eosino philia. and symptoms arising from larval invasions of different organs including the liver, lungs. eyes, and central nervous system. There has been only one case report of the computed tomographic (CT) and magnetic resonance imaging (MRI) appearances of cerebral toxocaral disease . Described here is a patient with cerebral toxocaral disease with a high eosinophil count and toxocaral titer in the serum and abnormal CT and MRI findings who had spontaneous recovery of the clinical symptoms. JF - Journal of Neuroimaging AU - Zachariah, Sally B AU - Zachariah, Babu AU - Varghese, Rachel AD - Department of Neurology University of South Florida College of Medicine H. Lee Moffitt Cancer Center Tampa, FL Veterans Administration Medical Center Bay Pines , FL. Y1 - 1994/01// PY - 1994 DA - January 1994 SP - 39 EP - 40 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 4 IS - 1 SN - 1051-2284, 1051-2284 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Central nervous system KW - Neuroimaging KW - Magnetic resonance imaging KW - Leukocytes (eosinophilic) KW - Migration KW - Leukocyte migration KW - Case reports KW - Lung KW - Computed tomography KW - Liver KW - Invasions KW - Spontaneous recovery KW - Nematoda KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785253288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroimaging&rft.atitle=Neuroimaging+Studies+of+Cerebral+%22visceral+Larva+Migrans%22+Syndrome&rft.au=Zachariah%2C+Sally+B%3BZachariah%2C+Babu%3BVarghese%2C+Rachel&rft.aulast=Zachariah&rft.aufirst=Sally&rft.date=1994-01-01&rft.volume=4&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroimaging&rft.issn=10512284&rft_id=info:doi/10.1111%2Fjon19944139 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Leukocyte migration; Central nervous system; Neuroimaging; Case reports; Lung; Magnetic resonance imaging; Computed tomography; Liver; Invasions; Leukocytes (eosinophilic); Spontaneous recovery; Migration; Nematoda DO - http://dx.doi.org/10.1111/jon19944139 ER - TY - JOUR T1 - Case Management Applications in Substance Use Disorders AN - 1761716920; 199504543 AB - Discusses the application of case management in services for people with alcohol & other drug dependence. The case management approach is appealing in part because it is flexible, & can be adapted to fit many different populations, problems, & settings. It is particularly useful when recipients of services demonstrate unusually complex or intransigent problems, or their problems persist over long periods of time. 18 References. Adapted from the source document. JF - Journal of Case Management AU - Willenbring, Mark L AD - 116A 4 Veterans Administration Medical Center, 1 Veterans Dr Minneapolis MN 55417 Y1 - 1994/01// PY - 1994 DA - January 1994 SP - 150 EP - 157 VL - 3 IS - 4 SN - 1061-3706, 1061-3706 KW - alcohol/drug dependence services, case management applications KW - Drug Addiction KW - Alcoholism KW - Delivery Systems KW - Social Work Cases KW - article KW - 6120: social work practice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761716920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Case+Management&rft.atitle=Case+Management+Applications+in+Substance+Use+Disorders&rft.au=Willenbring%2C+Mark+L&rft.aulast=Willenbring&rft.aufirst=Mark&rft.date=1994-01-01&rft.volume=3&rft.issue=4&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Journal+of+Case+Management&rft.issn=10613706&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Social Work Cases; Alcoholism; Drug Addiction; Delivery Systems ER - TY - JOUR T1 - Are Twelve Step Programs Appropriate for Disenfranchised Groups? Evidence from a Study of Posttreatment Mutual Help Involvement AN - 1761702197; 199601753 AB - To test the claim that 12-step mutual help programs for substance abusers appeal primarily to white, middle class men, interview data were collected from 558 persons at intake & 1 year following their admission to public substance abuse treatment programs in MI. Contrary to conventional wisdom, the 178 persons who were attending mutual help after treatment were not significantly different from the 380 who were not -- in terms of race, gender, education, employment pattern, or marital status. Supplemental analyses suggested that women were more likely to drop out of 12-step groups than men, & that African Americans who attended self-help after treatment had better outcomes on clinical & social measures than African Americans who did not attend. Overall, the findings suggest that 12-step programs both appeal to & benefit disenfranchised groups. 4 Tables, 12 References. Adapted from the source document. JF - Prevention in Human Services AU - Humphreys, Keith AU - Mavis, Brian E AU - Stoffelmayr, Bertram E AD - Center Health Care Evaluation Veterans Administration Medical Center, 795 Willow Rd #152 Menlo Park CA 94025 Y1 - 1994///0, PY - 1994 DA - 0, 1994 SP - 165 EP - 179 VL - 11 IS - 1 SN - 0270-3114, 0270-3114 KW - 12-step program value, disenfranchised (minority/female) substance abusers KW - interviews KW - Michigan KW - Treatment Outcomes KW - Black Americans KW - Substance Abuse KW - Self Help Groups KW - Females KW - article KW - 6123: self-help support groups/networks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761702197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prevention+in+Human+Services&rft.atitle=Are+Twelve+Step+Programs+Appropriate+for+Disenfranchised+Groups%3F+Evidence+from+a+Study+of+Posttreatment+Mutual+Help+Involvement&rft.au=Humphreys%2C+Keith%3BMavis%2C+Brian+E%3BStoffelmayr%2C+Bertram+E&rft.aulast=Humphreys&rft.aufirst=Keith&rft.date=1994-01-01&rft.volume=11&rft.issue=1&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Prevention+in+Human+Services&rft.issn=02703114&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Self Help Groups; Substance Abuse; Treatment Outcomes; Black Americans; Females; Michigan ER - TY - JOUR T1 - Treatment of murine lupus with CTLA4lg AN - 16947041; 176428 AB - The interaction of B7-related molecules on antigen-presenting cells with CD28 or CTLA-4 antigens on T cells provides a second signal for T cell activation. Selective inhibition of the B7-CD28 or B7-CTLA-4 interactions produces antigen-specific T cell unresponsiveness in vitro and suppresses immune function in vivo. To determine whether selective inhibition of the B7-CD28 or B7-CTLA-4 interactions could suppress spontaneous autoimmune disease, a B7-binding protein was generated by genetic fusion of the extracellular domain of murine CTLA-4 to the Fc portion of a mouse immunoglobulin G2a monoclonal antibody (muCTLA4lg). In lupus-prone NZB/NZW filial generation (F sub(1)) mice, treatment with muCTLA4lg blocked autoantibody production and prolonged life, even when treatment was delayed until the most advanced stage of clinical illness. These findings suggest a possible role for human CTLA4lg in the treatment of autoimmune diseases in humans. JF - Science (Washington) AU - Finck, Barbara K AU - Linsley, Peter S AU - Wofsy, David AD - Univ of California and Veterans Administration Medical Cent, San Francisco, CA, USA Y1 - 1994 PY - 1994 DA - 1994 SP - 1225 EP - 1227 PB - AMERICAN ASSOC FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC, (USA) VL - 265 IS - 5176 SN - 0036-8075, 0036-8075 KW - Autoantibody production blockers KW - Autoimmune diseases KW - Autoimmune response suppression KW - Drug products KW - Immunoglobulin monoclonal antibodies KW - Murine lupus treatment KW - Patient treatment KW - Selectively inhibited immune reactions KW - Systemic lupus erythematosus KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Prevention KW - Monoclonal antibodies KW - Genetic engineering KW - Immunology KW - W4 461.6:MEDICINE KW - W4 461.8.1:GENETIC ENGINEERING KW - W 30965:Miscellaneous, Reviews KW - W4 461.9.1:IMMUNOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16947041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=Treatment+of+murine+lupus+with+CTLA4lg&rft.au=Finck%2C+Barbara+K%3BLinsley%2C+Peter+S%3BWofsy%2C+David&rft.aulast=Finck&rft.aufirst=Barbara&rft.date=1994-01-01&rft.volume=265&rft.issue=5176&rft.spage=1225&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Prevention; Monoclonal antibodies; Immunology; Genetic engineering ER - TY - JOUR T1 - Role of isoprenoid metabolism in chemotactic peptide receptor-mediated G protein activation. AN - 76130023; 8267613 AB - The role of isoprenylation in formyl peptide receptor-mediated G protein activation was studied using plasma membranes isolated from normal HL-60 granulocytes and from cells in which isoprenylation was inhibited with mevastatin. Plasma membrane expression of formyl peptide receptors and G protein beta subunits, but not alpha i2 and alpha i3, was significantly reduced by inhibition of isoprenylation. This reduced expression resulted in impaired basal and fMet-Leu-Phe-stimulated G protein activation. JF - Biochemical and biophysical research communications AU - McLeish, K R AU - Lederer, E D AU - Klein, J B AD - Veterans Administration Medical Center, Louisville, KY. Y1 - 1993/12/15/ PY - 1993 DA - 1993 Dec 15 SP - 763 EP - 770 VL - 197 IS - 2 SN - 0006-291X, 0006-291X KW - Anticholesteremic Agents KW - 0 KW - Macromolecular Substances KW - Receptors, Formyl Peptide KW - Receptors, Immunologic KW - Receptors, Peptide KW - Virulence Factors, Bordetella KW - NAD KW - 0U46U6E8UK KW - mevastatin KW - 1UQM1K0W9X KW - Adenosine Diphosphate Ribose KW - 20762-30-5 KW - Guanosine 5'-O-(3-Thiotriphosphate) KW - 37589-80-3 KW - N-Formylmethionine Leucyl-Phenylalanine KW - 59880-97-6 KW - Guanosine Triphosphate KW - 86-01-1 KW - Cholera Toxin KW - 9012-63-9 KW - Lovastatin KW - 9LHU78OQFD KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Index Medicus KW - Humans KW - Cholera Toxin -- pharmacology KW - Anticholesteremic Agents -- pharmacology KW - Lovastatin -- pharmacology KW - Adenosine Diphosphate Ribose -- metabolism KW - Guanosine 5'-O-(3-Thiotriphosphate) -- pharmacology KW - Guanosine Triphosphate -- metabolism KW - Virulence Factors, Bordetella -- pharmacology KW - NAD -- metabolism KW - Virulence Factors, Bordetella -- metabolism KW - Tumor Cells, Cultured KW - Kinetics KW - Guanosine 5'-O-(3-Thiotriphosphate) -- metabolism KW - Cell Membrane -- metabolism KW - Lovastatin -- analogs & derivatives KW - Cholera Toxin -- metabolism KW - N-Formylmethionine Leucyl-Phenylalanine -- pharmacology KW - Receptors, Immunologic -- drug effects KW - Receptors, Peptide -- drug effects KW - Receptors, Peptide -- metabolism KW - Granulocytes -- metabolism KW - Receptors, Immunologic -- metabolism KW - GTP-Binding Proteins -- metabolism KW - GTP-Binding Proteins -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76130023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Role+of+isoprenoid+metabolism+in+chemotactic+peptide+receptor-mediated+G+protein+activation.&rft.au=McLeish%2C+K+R%3BLederer%2C+E+D%3BKlein%2C+J+B&rft.aulast=McLeish&rft.aufirst=K&rft.date=1993-12-15&rft.volume=197&rft.issue=2&rft.spage=763&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-01-25 N1 - Date created - 1994-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of spatial frequency in the processing of hierarchically organized stimuli. AN - 85187601; pmid-8134247 AB - Can spatial frequency differences between local and global forms account for differences in the way different levels of structure are analyzed? We examined this question by having subjects identify local or global forms of hierarchical stimuli that had been contrast balanced. Contrast balancing eliminates low spatial frequencies, so that both local and global forms must be identified on the basis of high spatial frequency information. Response times (RTs) to global (but not local) forms were slowed for contrast-balanced stimuli, suggesting that low spatial frequencies mediate the global RT advantage typically found. In contrast, interference between local and global forms was little affected by contrast balancing or by shifts of attention between local and global forms, suggesting that it does not result from inhibitory interactions between spatial frequency channels or from temporal precedence of low versus high spatial frequency information. Finally, shifts of attention between local and global forms were also little affected by contrast balancing, suggesting that they were not based on spatial frequency. JF - Perception and Psychophysics AU - Lamb, M R AU - Yund, E W AD - Veterans Administration Medical Center, Martinez, California 94553. PY - 1993 SP - 773 EP - 784 VL - 54 IS - 6 SN - 0031-5117, 0031-5117 KW - Photic Stimulation KW - Support, U.S. Gov't, P.H.S. KW - Contrast Sensitivity KW - Human KW - Adult KW - Support, U.S. Gov't, Non-P.H.S. KW - Middle Age KW - Adolescent KW - Visual Acuity KW - Male KW - Female KW - Reaction Time KW - Space Perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85187601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perception+and+Psychophysics&rft.atitle=The+role+of+spatial+frequency+in+the+processing+of+hierarchically+organized+stimuli.&rft.au=Lamb%2C+M+R%3BYund%2C+E+W&rft.aulast=Lamb&rft.aufirst=M&rft.date=1993-12-01&rft.volume=54&rft.issue=6&rft.spage=773&rft.isbn=&rft.btitle=&rft.title=Perception+and+Psychophysics&rft.issn=00315117&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Aluminum toxicity in patients with chronic renal failure. AN - 76250962; 8122300 AB - During the past two decades, in association with the commencement of chronic dialysis therapy and prolongation of the uremic state, aluminum toxicity has represented a major cause of morbidity and mortality in uremic patients. The uremic patient has been found to be at higher risk of aluminum loading and toxicity from various sources of parenteral exposure, enhanced gastrointestinal absorption, and compromised ability to eliminate any systemically administered aluminum due to renal impairment. However, the potential sources of aluminum exposure and loading resulting in toxicity in uremic patients have recently been identified. As a result, this toxicity can largely be prevented by eliminating aluminum from the water used to prepare the dialysate, substituting calcium-containing phosphate-binding agents for those containing aluminum, and strict avoidance of the concomitant use of citrate- and aluminum-containing compounds. Thus, in the future, aluminum toxicity should represent a rare and unusual side effect in dialyzed uremic patients. JF - Therapeutic drug monitoring AU - Alfrey, A C AD - Renal Section, Denver Veterans Administration Hospital, Colorado 80220. Y1 - 1993/12// PY - 1993 DA - December 1993 SP - 593 EP - 597 VL - 15 IS - 6 SN - 0163-4356, 0163-4356 KW - Dialysis Solutions KW - 0 KW - Aluminum KW - CPD4NFA903 KW - Index Medicus KW - Dialysis Solutions -- adverse effects KW - Humans KW - Nervous System Diseases -- chemically induced KW - Bone Diseases -- chemically induced KW - Aluminum -- adverse effects KW - Kidney Failure, Chronic -- metabolism KW - Aluminum -- metabolism KW - Kidney Failure, Chronic -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/76250962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Therapeutic+drug+monitoring&rft.atitle=Aluminum+toxicity+in+patients+with+chronic+renal+failure.&rft.au=Alfrey%2C+A+C&rft.aulast=Alfrey&rft.aufirst=A&rft.date=1993-12-01&rft.volume=15&rft.issue=6&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Therapeutic+drug+monitoring&rft.issn=01634356&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 1994-04-07 N1 - Date created - 1994-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER -