TY - JOUR T1 - Rotating methadone to other opioids: a lesson in the mechanisms of opioid tolerance and opioid-induced pain. AN - 67891475; 16629581 JF - Journal of palliative medicine AU - Prommer, Eric AD - UCLA School of Medicine, Division of Hematology/Oncology, VIP Palliative Care Program, Greater Los Angeles Healthcare, 90073, USA. Eric.prommer@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 488 EP - 493 VL - 9 IS - 2 SN - 1096-6218, 1096-6218 KW - Narcotics KW - 0 KW - Receptors, N-Methyl-D-Aspartate KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - United States KW - Drug Tolerance KW - Humans KW - Adult KW - Hyperalgesia KW - Male KW - Methadone -- therapeutic use KW - Pain -- chemically induced KW - Narcotics -- therapeutic use KW - Narcotics -- adverse effects KW - Narcotics -- administration & dosage KW - Narcotics -- poisoning KW - Methadone -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67891475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+palliative+medicine&rft.atitle=Rotating+methadone+to+other+opioids%3A+a+lesson+in+the+mechanisms+of+opioid+tolerance+and+opioid-induced+pain.&rft.au=Prommer%2C+Eric&rft.aulast=Prommer&rft.aufirst=Eric&rft.date=2006-04-01&rft.volume=9&rft.issue=2&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Journal+of+palliative+medicine&rft.issn=10966218&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-12 N1 - Date created - 2006-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk of mortality associated with antipsychotic and other neuropsychiatric drugs in pneumonia patients. AN - 67887401; 16633149 AB - To evaluate the use of typical and atypical antipsychotic medications and associated in-hospital mortality in a group of Veterans Administration (VA) patients with pneumonia. Our cohort consisted of 14,057 VA patients admitted for pneumonia in fiscal year (FY) 2003. Exposure to typical and atypical antipsychotics and other neuropsychiatric drugs was based on a prescription within 120 days preceding admission. Multivariate models determined the odds of mortality associated with each drug class and risk adjusted for comorbidity, admission source, demographic factors, and concurrent mental health conditions. The referent group for each analysis was pneumonia patients not receiving neuropsychiatric drugs. In adjusted analyses, the odds of in-hospital mortality for VA patients admitted with pneumonia was higher for recent exposure to typical antipsychotics (OR = 1.51, 95% CI = 1.04-2.19; P = 0.03) when compared to patients not receiving neuropsychiatric medications. Patients exposed to atypical antipsychotics (OR = 1.20, 95% CI = 0.96-1.50, P = .10), tricyclic antidepressants (OR = 1.20, 95% CI = 0.44-1.55; P = 0.15), other antidepressants (OR = 1.07, 95% CI = 0.93-1.23; P = 0.37), or mood stabilizers (OR = 0.91, 95% CI = 0.73-1.14; P = 0.41) had no significant difference in in-hospital mortality. In spite of recent safety concerns for atypical antipsychotics, we found no increased risk of mortality in acutely ill pneumonia patients. Rather, we found a higher adjusted mortality rate for patients taking typical antipsychotics. The contrasting mortality risks for patients taking typical and atypical antipsychotics may represent unmeasured severity of illness or comorbidity. Regardless, any antipsychotics should be used with caution and the efficacy and safety of alternative agents should be considered. JF - Journal of clinical psychopharmacology AU - Barnett, Mitchell J AU - Perry, Paul J AU - Alexander, Bruce AU - Kaboli, Peter J AD - The Center for Research in the Implementation of Innovative Strategies in Practice, Iowa City Veterans Administration Hospital, Iowa City, IA 52246, USA. barnettm@mail.medicine.uiowa.edu Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 182 EP - 187 VL - 26 IS - 2 SN - 0271-0749, 0271-0749 KW - Antidepressive Agents, Tricyclic KW - 0 KW - Antipsychotic Agents KW - Tranquilizing Agents KW - Index Medicus KW - United States KW - Length of Stay KW - United States Department of Veterans Affairs KW - Risk Factors KW - Humans KW - Hospital Mortality KW - Cohort Studies KW - Aged KW - Male KW - Female KW - Survival Analysis KW - Pneumonia -- mortality KW - Antipsychotic Agents -- therapeutic use KW - Antidepressive Agents, Tricyclic -- therapeutic use KW - Antidepressive Agents, Tricyclic -- adverse effects KW - Tranquilizing Agents -- therapeutic use KW - Tranquilizing Agents -- adverse effects KW - Pneumonia -- drug therapy KW - Antipsychotic Agents -- adverse effects KW - Health Services for the Aged UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67887401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Risk+of+mortality+associated+with+antipsychotic+and+other+neuropsychiatric+drugs+in+pneumonia+patients.&rft.au=Barnett%2C+Mitchell+J%3BPerry%2C+Paul+J%3BAlexander%2C+Bruce%3BKaboli%2C+Peter+J&rft.aulast=Barnett&rft.aufirst=Mitchell&rft.date=2006-04-01&rft.volume=26&rft.issue=2&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-04 N1 - Date created - 2006-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Case report: lack of control of diabetes and weight gain in a patient on initiation and rechallenge of therapy with olanzapine. AN - 67881348; 16623611 AB - The following is a case report analysis intended to draw attention to the need for better care coordination by describing the observed relationship of olanzapine to metabolic changes manifested as uncontrolled diabetes mellitus and weight gain. A 47-year-old male with bipolar I disorder/hallucinations presented to the Veterans Affairs Medical Center (VAMC) with suicidal ideations. He was referred to the psychiatry service where he was treated with olanzapine. He was followed exclusively by the psychiatry service for more than a year. During that time,weight issues and diabetes status were not addressed. Upon presenting to the primary care service a year and a half later, the patient was taking 40 mg per day of olanzapine and had gained 62 pounds, a 30% increase in body weight; glycosylated hemoglobin (A1c) was 11.1%. The patient was enrolled in a weight-loss clinic, and his diabetes medications were adjusted.Subsequently, olanzapine was discontinued because of weight gain and uncontrolled diabetes. Blood sugar and A1c were finally stabilized one month after discontinuation of olanzapine (A1c,6.9%). The patient experienced a relapse in his bipolar disorder,and olanzapine was restarted at 20 to 40 mg per day. His blood sugar became uncontrolled, he gained 13 pounds, and his A1c increased to 9.4%. JF - Journal of managed care pharmacy : JMCP AU - Schwetschenau, Kristen H AD - Department of Veterans Affairs, Cincinnati, OH 45220, USA. Kristen.Schwetschenau@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 260 EP - 262 VL - 12 IS - 3 SN - 1083-4087, 1083-4087 KW - Antipsychotic Agents KW - 0 KW - Hypoglycemic Agents KW - Benzodiazepines KW - 12794-10-4 KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - Hypoglycemic Agents -- therapeutic use KW - Benzodiazepines -- adverse effects KW - Humans KW - Middle Aged KW - Male KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Weight Gain -- drug effects KW - Hyperglycemia -- chemically induced KW - Diabetes Mellitus, Type 2 -- complications KW - Bipolar Disorder -- drug therapy KW - Antipsychotic Agents -- adverse effects KW - Bipolar Disorder -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67881348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+managed+care+pharmacy+%3A+JMCP&rft.atitle=Case+report%3A+lack+of+control+of+diabetes+and+weight+gain+in+a+patient+on+initiation+and+rechallenge+of+therapy+with+olanzapine.&rft.au=Schwetschenau%2C+Kristen+H&rft.aulast=Schwetschenau&rft.aufirst=Kristen&rft.date=2006-04-01&rft.volume=12&rft.issue=3&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Journal+of+managed+care+pharmacy+%3A+JMCP&rft.issn=10834087&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-22 N1 - Date created - 2006-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Black patients with chronic hepatitis C have a lower sustained viral response rate than non-Blacks with genotype 1, but the same with genotypes 2/3, and this is not explained by more frequent dose reductions of interferon and ribavirin*. AN - 67862466; 16611190 AB - In previous hepatitis C virus (HCV) treatment studies, Black patients not only had a lower sustained viral response (SVR) rate to interferon and ribavirin (RBV) than non-Black patients but also a higher frequency of HCV genotype 1 (GT-1) infection. The aim of this community-based study was to determine whether Black patients have a lower SVR rate independent of genotype. We prospectively enrolled 785 patients (24.8% Black, 71.5% White, 3.7% others) who received interferon alpha-2b 3 MU three times weekly + RBV 1000-1200 mg/day for 24 weeks (GT-2/3) or 48 weeks (GT-1). Black patients were more commonly infected with GT-1 (86.8%vs 64.8%, P < 0.001) and less frequently had an SVR compared with non-Black patients (8.4%vs 21.6%, P < 0.001). Within GT-1, Black patients had a lower SVR rate than non-Black patients (6.1%vs 14.1%, P = 0.004) but not within GT-2/3 (50.0%vs 36.5%, P = 0.47). Black patients had lower baseline haemoglobin levels (14.8 vs 15.3 g/dL, P < 0.001) and neutrophil counts (2900 vs 4100/mm(3), P < 0.001) and required more frequent dose reductions of RBV (29.8%vs 18.5%, P < 0.001) and interferon (4.7%vs 1.6%, P = 0.012). However, dose reductions were not associated with lower SVR rates while early treatment discontinuations were (2.9%vs 25.7%, P < 0.001). Independent predictors of SVR were GT-1 [odds ratio (OR) 0.33; 95% confidence interval (CI) 0.20-0.55; P < 0.001], Black race (OR 0.45; 95% CI 0.22-0.93; P = 0.030), and advanced fibrosis, stages 3 + 4 (OR 0.53; 95% CI 0.31-0.92; P = 0.023). In conclusion, Black patients infected with HCV GT-1 (but not GT-2/3) have a lower SVR rate than non-Black patients. This is not explained by their lower baseline haemoglobin levels and neutrophil counts that lead to higher rates of ribavirin and interferon dose reductions. JF - Journal of viral hepatitis AU - Bräu, N AU - Bini, E J AU - Currie, S AU - Shen, H AU - Schmidt, W N AU - King, P D AU - Ho, S B AU - Cheung, R C AU - Hu, K-Q AU - Anand, B S AU - Simon, F R AU - Aytaman, A AU - Johnson, D P AU - Awad, J A AU - Ahmad, J AU - Mendenhall, C L AU - Pedrosa, M C AU - Moseley, R H AU - Hagedorn, C H AU - Waters, B AU - Chang, K-M AU - Morgan, T R AU - Rossi, S J AU - Jeffers, L J AU - Wright, T L AU - VA-HCV-001 Study Group AD - Veteran Affairs Medical Centers, Bronx, NY 10468, USA. norbert.brau@med.va.gov ; VA-HCV-001 Study Group Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 242 EP - 249 VL - 13 IS - 4 SN - 1352-0504, 1352-0504 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - RNA, Viral KW - Ribavirin KW - 49717AWG6K KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Liver Cirrhosis -- pathology KW - Dose-Response Relationship, Drug KW - Humans KW - Biopsy KW - Multivariate Analysis KW - Genotype KW - Alanine Transaminase -- blood KW - Prospective Studies KW - Logistic Models KW - European Continental Ancestry Group KW - Middle Aged KW - Female KW - Male KW - RNA, Viral -- blood KW - Antiviral Agents -- administration & dosage KW - Interferon-alpha -- adverse effects KW - Interferon-alpha -- administration & dosage KW - Hepatitis C, Chronic -- blood KW - Hepacivirus -- genetics KW - Hepatitis C, Chronic -- drug therapy KW - Hepatitis C, Chronic -- virology KW - Ribavirin -- administration & dosage KW - Antiviral Agents -- adverse effects KW - African Continental Ancestry Group KW - Ribavirin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67862466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+viral+hepatitis&rft.atitle=Black+patients+with+chronic+hepatitis+C+have+a+lower+sustained+viral+response+rate+than+non-Blacks+with+genotype+1%2C+but+the+same+with+genotypes+2%2F3%2C+and+this+is+not+explained+by+more+frequent+dose+reductions+of+interferon+and+ribavirin*.&rft.au=Br%C3%A4u%2C+N%3BBini%2C+E+J%3BCurrie%2C+S%3BShen%2C+H%3BSchmidt%2C+W+N%3BKing%2C+P+D%3BHo%2C+S+B%3BCheung%2C+R+C%3BHu%2C+K-Q%3BAnand%2C+B+S%3BSimon%2C+F+R%3BAytaman%2C+A%3BJohnson%2C+D+P%3BAwad%2C+J+A%3BAhmad%2C+J%3BMendenhall%2C+C+L%3BPedrosa%2C+M+C%3BMoseley%2C+R+H%3BHagedorn%2C+C+H%3BWaters%2C+B%3BChang%2C+K-M%3BMorgan%2C+T+R%3BRossi%2C+S+J%3BJeffers%2C+L+J%3BWright%2C+T+L%3BVA-HCV-001+Study+Group&rft.aulast=Br%C3%A4u&rft.aufirst=N&rft.date=2006-04-01&rft.volume=13&rft.issue=4&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Journal+of+viral+hepatitis&rft.issn=13520504&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-06 N1 - Date created - 2006-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A randomized clinical trial of a new behavioral treatment for drug abuse in people with severe and persistent mental illness. AN - 67828892; 16585472 AB - Drug abuse by people with severe mental disorder is a significant public health problem for which there is no empirically validated treatment. To evaluate the efficacy of a new behavioral treatment for drug abuse in this population: Behavioral Treatment for Substance Abuse in Severe and Persistent Mental Illness (BTSAS). Participants were randomly assigned to 6 months of treatment in either BTSAS or a manualized control condition: Supportive Treatment for Addiction Recovery (STAR). Treatment was conducted in community-based outpatient clinics and a Veterans Affairs medical center in Baltimore, Md. Participants were 129 stabilized outpatients meeting DSM criteria for drug dependence (cocaine, heroin, or cannabis) and serious mental illness: 39.5% met DSM-IV criteria for schizophrenia or schizoaffective disorder; 55.8%, for major affective disorders; and the remainder met criteria for severe and persistent mental illness and other Axis I disorders. Both treatments were administered by trained health care professionals in small groups, twice a week for 6 months. The BTSAS program is a social learning intervention that includes motivational interviewing, a urinalysis contingency, and social skills training. The control condition, STAR, is a supportive group discussion treatment. Main Outcome Measure The primary outcome measure was urinalysis results from twice-weekly treatment sessions. The BTSAS program was significantly more effective than STAR in percentage of clean urine test results, survival in treatment, and attendance at sessions. The BTSAS program also had significant effects on important community-functioning variables, including hospitalization; money available for living expenses; and quality of life. The BTSAS program is an efficacious treatment. Further work needs to be done to increase the proportion of eligible patients who are able to become engaged in treatment. JF - Archives of general psychiatry AU - Bellack, Alan S AU - Bennett, Melanie E AU - Gearon, Jean S AU - Brown, Clayton H AU - Yang, Ye AD - University of Maryland School of Medicine and Veterans Affairs Capitol Health Care Network Mental Illness Research, Education, Baltimore, 21201, USA. alan.bellack@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 426 EP - 432 VL - 63 IS - 4 SN - 0003-990X, 0003-990X KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Depressive Disorder, Major -- diagnosis KW - Psychotic Disorders -- therapy KW - Humans KW - Schizophrenia -- diagnosis KW - Diagnosis, Dual (Psychiatry) KW - Quality of Life KW - Depressive Disorder, Major -- epidemiology KW - Depressive Disorder, Major -- therapy KW - Outcome Assessment (Health Care) KW - Schizophrenia -- therapy KW - Psychotic Disorders -- epidemiology KW - Community Mental Health Services KW - Comorbidity KW - Ambulatory Care KW - Psychotherapy, Group KW - Psychiatric Status Rating Scales KW - Substance Abuse Detection KW - Treatment Outcome KW - Middle Aged KW - Schizophrenia -- epidemiology KW - Psychotic Disorders -- diagnosis KW - Female KW - Male KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Mental Disorders -- diagnosis KW - Mental Disorders -- epidemiology KW - Behavior Therapy -- methods KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67828892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=A+randomized+clinical+trial+of+a+new+behavioral+treatment+for+drug+abuse+in+people+with+severe+and+persistent+mental+illness.&rft.au=Bellack%2C+Alan+S%3BBennett%2C+Melanie+E%3BGearon%2C+Jean+S%3BBrown%2C+Clayton+H%3BYang%2C+Ye&rft.aulast=Bellack&rft.aufirst=Alan&rft.date=2006-04-01&rft.volume=63&rft.issue=4&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-11 N1 - Date created - 2006-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Randomized trial of onsite versus referral primary medical care for veterans in addictions treatment. AN - 67799653; 16565634 AB - Patients presenting for treatment of substance use disorders (SUDs) often exhibit medical comorbidities that affect functional health status and healthcare costs. Providing primary care within addictions clinics (onsite care) may improve medical and SUD treatment outcomes in this population. The objective of this study was to compare outcomes among Veterans' Administration (VA) patients who receive medical care within the SUD clinic and those referred to a general medicine clinic at the same facility. Veterans entering SUD treatment with a chronic medical condition and no current primary care were randomized to receive primary medical care: 1) onsite in the VA SUD clinic (n = 358), or 2) in the VA general internal medicine clinic (n = 362). Subjects were assessed at baseline and at 3, 6, and 12 months postrandomization. Intention-to-treat analyses used random-effects regression. Measures included SF-36 Physical and Mental Component Summaries (PCS, MCS), VA service utilization, SUD treatment retention, Addiction Severity Index (ASI) scores, 30-day abstinence, and total VA healthcare costs. Over the study year, patients assigned to onsite care were more likely to attend primary care (adjusted odds ratio [OR] = 2.20; 95% confidence interval [CI] = 1.53-3.15) and to remain engaged in SUD treatment at 3 months (adjusted OR = 1.36; 1.00-1.84). Overall, outcomes on the MCS (but not the PCS) and the ASI improved significantly over time but did not differ by treatment condition. Total VA healthcare costs did not differ reliably across conditions. Compared with referral care, providing primary care within a VA addiction clinic increased primary care access and initial SUD treatment retention but showed no effect on overall health status or costs. JF - Medical care AU - Saxon, Andrew J AU - Malte, Carol A AU - Sloan, Kevin L AU - Baer, John S AU - Calsyn, Donald A AU - Nichol, Paul AU - Chapko, Michael K AU - Kivlahan, Daniel R AD - VA Puget Sound Health Care System, Seattle, Washington 98108, USA. Andrew.Saxon@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 334 EP - 342 VL - 44 IS - 4 SN - 0025-7079, 0025-7079 KW - Index Medicus KW - Continuity of Patient Care -- organization & administration KW - Odds Ratio KW - Washington KW - Humans KW - Internal Medicine KW - Outcome Assessment (Health Care) KW - Comorbidity KW - Patient Satisfaction -- statistics & numerical data KW - Patient Compliance KW - Adult KW - Treatment Outcome KW - Confidence Intervals KW - Middle Aged KW - Female KW - Male KW - Substance-Related Disorders -- therapy KW - Primary Health Care -- utilization KW - Veterans -- psychology KW - Referral and Consultation KW - Hospitals, Veterans -- organization & administration KW - Substance-Related Disorders -- economics KW - Substance Abuse Treatment Centers -- economics KW - Hospitals, Veterans -- utilization KW - Substance Abuse Treatment Centers -- utilization KW - Primary Health Care -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67799653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=Randomized+trial+of+onsite+versus+referral+primary+medical+care+for+veterans+in+addictions+treatment.&rft.au=Saxon%2C+Andrew+J%3BMalte%2C+Carol+A%3BSloan%2C+Kevin+L%3BBaer%2C+John+S%3BCalsyn%2C+Donald+A%3BNichol%2C+Paul%3BChapko%2C+Michael+K%3BKivlahan%2C+Daniel+R&rft.aulast=Saxon&rft.aufirst=Andrew&rft.date=2006-04-01&rft.volume=44&rft.issue=4&rft.spage=334&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=00257079&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-27 N1 - Date created - 2006-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sweet intake, sweet-liking, urges to eat, and weight change: relationship to alcohol dependence and abstinence. AN - 67780176; 15990241 AB - Linkages between alcohol dependence (AD) and abstinence and aspects of food ingestion and preference have been described in animals and humans, including (1) eating sweets decreases urges to drink alcohol; (2) preferences for highly sweet tastants is associated with alcohol dependence; and (3) food deprivation leads to increased alcohol intake. We randomly assigned AD subjects in early abstinence to 3 different sets of dietary instructions (eat sweets for alcohol urges; eat a balanced diet; avoid sweets). We compared the groups on urges for alcohol, alcohol consumption, weight, and sweet preference at baseline, one, and six months. We also compared these AD subjects with light-drinking C's and compared AD subjects who remained abstinent for 6 month follow-up with nonabstinent AD subjects. Recruited AS subjects, 38 of 68, completed 6 month follow-up; 27 of 36 C's completed the follow-up. 21 AD's were abstinent while 17 were non-abstinent. There was no effect of dietary recommendations on urges to drink or alcohol consumption. AD's were more likely than C's to prefer highly sweet tastants. The proportion of AD's preferring the sweetest tastant decreased over time. AD's gained more weight than C's over the 6-month follow-up. While the use of sweets did not affect urges to drink or drinking, important relationships between sweet preference, weight gain, and alcohol dependence or abstinence were identified. JF - Addictive behaviors AU - Krahn, Dean AU - Grossman, Jennifer AU - Henk, Henry AU - Mussey, Mary AU - Crosby, Ross AU - Gosnell, Blake AD - Wm. S. Middleton Memorial Veterans Hospital, Psychiatry Service, 2500 Overlook Terrace, and University of Wisconsin Medical School, Madison, Wisconsin 53705, United States. dean.krahn@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 622 EP - 631 VL - 31 IS - 4 SN - 0306-4603, 0306-4603 KW - Dietary Sucrose KW - 0 KW - Sucrose KW - 57-50-1 KW - Index Medicus KW - Food Preferences -- psychology KW - Motivation KW - Humans KW - Aged KW - Taste KW - Appetite KW - Dietary Sucrose -- administration & dosage KW - Adult KW - Temperance -- psychology KW - Alcohol Drinking -- physiopathology KW - Alcohol Drinking -- psychology KW - Middle Aged KW - Sucrose -- administration & dosage KW - Male KW - Diet -- psychology KW - Candy KW - Eating -- psychology KW - Alcoholism -- physiopathology KW - Weight Gain -- physiology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67780176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Sweet+intake%2C+sweet-liking%2C+urges+to+eat%2C+and+weight+change%3A+relationship+to+alcohol+dependence+and+abstinence.&rft.au=Krahn%2C+Dean%3BGrossman%2C+Jennifer%3BHenk%2C+Henry%3BMussey%2C+Mary%3BCrosby%2C+Ross%3BGosnell%2C+Blake&rft.aulast=Krahn&rft.aufirst=Dean&rft.date=2006-04-01&rft.volume=31&rft.issue=4&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-05 N1 - Date created - 2006-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Majority of patients with hepatitis C express physical, mental, and social difficulties with antiviral treatment. AN - 67749863; 16538109 AB - The hepatitis C virus can be successfully treated in up to 60% of infected patients. However, treatment is long and is associated with significant side-effects. We investigated difficulties with this treatment as it is an important factor in patient adherence. Patients receiving hepatitis C treatment in a tertiary referral center were enrolled in a cross-sectional study. Demographic data, functional and emotional status, and co-morbidities were collected from patients or abstracted from the medical records. All participants underwent a semistructured interview, which was analysed by blinded coders. A total of 65 patients (mean age 46.1 years; 38.5% women) were enrolled. Fifty-two (80%) described moderate to severe problems attributed to treatment, with a predominance of physical difficulties (fatigue 74% of cases; flu-like symptoms 32%). Approximately one third of patients (38%) experienced depression during treatment. In 31% of cases, physical or emotional problems forced patients to quit their jobs or reduce employment. One fifth attributed deteriorating relationships with friends and family to adverse treatment effects. Necessary lifestyle adjustments, such as alcohol abstinence, caused frictions with friends in 22% of the participants. Our findings show a high prevalence of significant adverse effects in patients undergoing antiviral therapy. Whereas the nature and severity of these adverse reactions is consistent with earlier reports, we identified implications with worsening private and professional relationships. To encourage appropriate levels of adherence, healthcare providers should seek information about these indirect treatment effects as they monitor their patients on therapy. JF - European journal of gastroenterology & hepatology AU - Zickmund, Susan L AU - Bryce, Cindy L AU - Blasiole, Julie A AU - Shinkunas, Laura AU - LaBrecque, Douglas R AU - Arnold, Robert M AD - Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. susan.zickmund@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 381 EP - 388 VL - 18 IS - 4 SN - 0954-691X, 0954-691X KW - Antiviral Agents KW - 0 KW - Index Medicus KW - Analysis of Variance KW - Humans KW - Interpersonal Relations KW - Activities of Daily Living KW - Quality of Life -- psychology KW - Comorbidity KW - Cross-Sectional Studies KW - Patient Compliance KW - Adult KW - Middle Aged KW - Midwestern United States KW - Female KW - Male KW - Prevalence KW - Depression -- etiology KW - Hepatitis C, Chronic -- psychology KW - Hepatitis C, Chronic -- drug therapy KW - Hepatitis C, Chronic -- complications KW - Fatigue -- etiology KW - Antiviral Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67749863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+gastroenterology+%26+hepatology&rft.atitle=Majority+of+patients+with+hepatitis+C+express+physical%2C+mental%2C+and+social+difficulties+with+antiviral+treatment.&rft.au=Zickmund%2C+Susan+L%3BBryce%2C+Cindy+L%3BBlasiole%2C+Julie+A%3BShinkunas%2C+Laura%3BLaBrecque%2C+Douglas+R%3BArnold%2C+Robert+M&rft.aulast=Zickmund&rft.aufirst=Susan&rft.date=2006-04-01&rft.volume=18&rft.issue=4&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=European+journal+of+gastroenterology+%26+hepatology&rft.issn=0954691X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-09 N1 - Date created - 2006-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An emerging role for calcineurin Aalpha in the development and function of the kidney. AN - 67731577; 16527922 AB - For many years, calcineurin has been a familiar molecule as a target of the immunosuppressive agents cyclosporin A and FK-506. Calcineurin inhibition interferes with T cell signaling by preventing activation of the transcription factor NFATc. However, calcineurin is expressed in most tissues in the body, and calcineurin inhibition undoubtedly alters many other cellular processes. As a result, serious side effects of calcineurin inhibitors regularly occur, including hypertension and renal dysfunction. Because nephrotoxicity is often a barrier to continued clinical use of calcineurin inhibitors, understanding the role of calcineurin in the kidney is of particular importance. Recent work has demonstrated that the two main isoforms of the catalytic subunit of calcineurin, Aalpha and Abeta, may have distinct functions, particularly in the kidney. Calcineurin isoforms may be differentially expressed, and/or the activity of each may be differentially regulated, leading to tissue-specific functions. Differences between the action of the two isoforms are most evident in knockout mice lacking each isoform. Mice lacking the beta-isoform are characterized principally by altered development and function of immune cells. alpha-Knockout mice, in contrast, can still be immune suppressed by cyclosporin A but display pervasive developmental defects, including renal dysfunction. Therefore, it is intriguing to consider that while the beta-isoform may be responsible for calcineurin action in T cells, the alpha-isoform may be the predominant catalytic isoform in the kidney. This conclusion, if correct, may have substantial clinical implication for novel strategies to selectively target calcineurin action in T cells without associated nephrotoxicity. JF - American journal of physiology. Renal physiology AU - Gooch, Jennifer L AD - Department of Medicine/Division of Nephrology, Emory University School of Medicine, and Atlanta Veterans Administration Medical Center, Atlanta, Georgia 30322, USA. jgooch@emory.edu Y1 - 2006/04// PY - 2006 DA - April 2006 SP - F769 EP - F776 VL - 290 IS - 4 SN - 1931-857X, 1931-857X KW - Calcineurin Inhibitors KW - 0 KW - Protein Isoforms KW - Calcineurin KW - EC 3.1.3.16 KW - Index Medicus KW - Animals KW - Humans KW - Molecular Sequence Data KW - Mice KW - Amino Acid Sequence KW - T-Lymphocytes KW - Mice, Knockout KW - Catalysis KW - Calcineurin -- physiology KW - Kidney -- growth & development KW - Kidney -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67731577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Renal+physiology&rft.atitle=An+emerging+role+for+calcineurin+Aalpha+in+the+development+and+function+of+the+kidney.&rft.au=Gooch%2C+Jennifer+L&rft.aulast=Gooch&rft.aufirst=Jennifer&rft.date=2006-04-01&rft.volume=290&rft.issue=4&rft.spage=F769&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Renal+physiology&rft.issn=1931857X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2006-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Does Expressive Writing Reduce Health Care Utilization? A Meta-Analysis of Randomized Trials AN - 57219766; 200612649 AB - This meta-analysis examined whether writing about stressful experiences affects health care utilization (HCU) compared with writing on neutral topics or no-writing control groups. Randomized controlled trials of 30 independent samples representing 2,294 participants were located that contained sufficient information to calculate effect sizes. After omitting one study as an outlier, the effects were combined within 3 homogeneous groups: healthy samples (13 studies), samples with preexisting medical conditions (6 studies), & samples prescreened for psychological criteria (10 studies). Combined effect sizes, Hedges's g (95% confidence interval), with random effects estimation were 0.16 (0.02, 0.31), 0.21 (-0.02, 0.43), & 0.06 (-0.12, 0.24), respectively. Writing about stressful experiences reduces HCU in healthy samples but not in samples defined by medical diagnoses or exposure to stress or other psychological factors. The significance of these effects for individuals' health is unknown. 4 Tables, 1 Figure, 53 References. [Copyright 2006 American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Harris, Alex H S AD - Center Health Care Evaluation, U.S. Dept Veterans Affairs, Menlo Park, CA Alexander.Harris2@va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 243 EP - 252 PB - American Psychological Association, Washington DC VL - 74 IS - 2 SN - 0022-006X, 0022-006X KW - writing, written expression, health care utilization, meta-analysis, health KW - Users KW - Health care KW - Writing KW - Meta-analysis KW - Stressful events KW - Health behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57219766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=Does+Expressive+Writing+Reduce+Health+Care+Utilization%3F+A+Meta-Analysis+of+Randomized+Trials&rft.au=Harris%2C+Alex+H+S&rft.aulast=Harris&rft.aufirst=Alex+H&rft.date=2006-04-01&rft.volume=74&rft.issue=2&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2F0022-006X.74.2.243 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Writing; Stressful events; Meta-analysis; Health behaviour; Health care; Users DO - http://dx.doi.org/10.1037/0022-006X.74.2.243 ER - TY - JOUR T1 - Taking Charge: A Pilot Curriculum of Self-Defense and Personal Safety Training for Female Veterans with PTSD Because of Military Sexual Trauma AN - 57110481; 200704592 AB - The authors describe an overview of the pilot project Taking Charge, a 36-hour comprehensive behavioral intervention involving psychoeducation, personal safety, & self-defense training for 12 female veterans with posttraumatic stress disorder (PTSD) from military sexual trauma. Self-defense training can incorporate the benefits of repeated exposure while teaching proactive cognitive & behavioral responses to the feared stimuli, & thus facilitate emotional & physical rescripting of & mastery over the trauma. Results up to 6 months follow-up indicate significant reductions in behavioral avoidance, PTSD hyperarousal, & depression, with significant increases in interpersonal, activity, & self-defense self-efficacy. The authors propose that this therapeutic self-defense curriculum provides an enhanced exposure therapy paradigm that may be a potent therapeutic tool in the treatment of PTSD. Tables, References. [Reprinted by permission of Sage Publications Inc., copyright 2006.] JF - Journal of Interpersonal Violence AU - David, Wendy S AU - Simpson, Tracy L AU - Cotton, Ann J AD - VA Puget Sound Health Care System, Seattle, WA wendy.david@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 555 EP - 565 PB - Sage Publications, Thousand Oaks CA VL - 21 IS - 4 SN - 0886-2605, 0886-2605 KW - posttraumatic stress disorder KW - women veterans KW - personal safety KW - self-defense KW - Veterans KW - Posttraumatic stress disorder KW - Exposure therapy KW - Behaviour therapy KW - Women KW - Selfdefence training KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57110481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interpersonal+Violence&rft.atitle=Taking+Charge%3A+A+Pilot+Curriculum+of+Self-Defense+and+Personal+Safety+Training+for+Female+Veterans+with+PTSD+Because+of+Military+Sexual+Trauma&rft.au=David%2C+Wendy+S%3BSimpson%2C+Tracy+L%3BCotton%2C+Ann+J&rft.aulast=David&rft.aufirst=Wendy&rft.date=2006-04-01&rft.volume=21&rft.issue=4&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interpersonal+Violence&rft.issn=08862605&rft_id=info:doi/10.1177%2F0886260505285723 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-05-30 N1 - Last updated - 2016-09-27 N1 - CODEN - JIVIEI N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Women; Veterans; Selfdefence training; Exposure therapy; Behaviour therapy DO - http://dx.doi.org/10.1177/0886260505285723 ER - TY - JOUR T1 - IL-4-Induced Peroxisome Proliferator-Activated Receptor gamma Activation Inhibits NF- Kappa B Trans Activation in Central Nervous System (CNS) Glial Cells and Protects Oligodendrocyte Progenitors under Neuroinflammatory Disease Conditions: Implication for CNS-Demyelinating Diseases AN - 20240986; 6748737 AB - Th2 phenotype cytokine, IL-4, plays an important role in the regulation of Th1 cell responses and spontaneous remission of inflammatory CNS demyelinating diseases such as multiple sclerosis (MS). In this study we demonstrate IL-4-induced down-regulation of inducible NO synthase (iNOS) expression and survival of differentiating oligodendrocyte progenitors (OPs) in proinflammatory cytokine (Cyt-Mix)-treated CNS glial cells, which is a condition similar to that observed in the brain of a patient with MS. IL-4 treatment of Cyt-Mix-treated CNS glial cells significantly decreased iNOS expression/NO release with a parallel increase in survival of differentiating OPs. IL-4 effects were concentration-dependent and could be reversed by anti-IL-4R Abs. The use of inhibitors for Akt, p38 MAPK, and peroxisome proliferator-activated receptor gamma (PPAR- gamma ) antagonist revealed that inhibition of Cyt-Mix-induced iNOS expression and survival of differentiating OPs by IL-4 is via PPAR- gamma activation. There was a coordinate increase in the expression of both PPAR- gamma and its natural ligand-producing enzyme 12/15-lipoxygenase (12/15-LOX) in IL-4-treated cells. Next, EMSA, immunoblots, and transient cotransfection studies with reporter plasmids (pNF- Kappa B-Luc and pTK-PPREx3-Luc) and 12/15-LOX small interfering RNA revealed that IL-4-induced PPAR- gamma activation antagonizes NF- Kappa B transactivation in Cyt-Mix-treated astrocytes. In support of this finding, similarly treated 12/15-LOX super(-/-) CNS glial cells further corroborated the result. Furthermore, there was reversal of IL-4 inductive effects in the brain of LPS-challenged 12/15-LOX super(-/-) mice when compared with LPS-challenged wild-type mice. Together, these data for the first time demonstrate the inhibition of Cyt-Mix-induced NF- Kappa B transactivation in CNS glial cells by IL-4 via PPAR- gamma activation, hence its implication for the protection of differentiating OPs during MS and other CNS demyelinating diseases. JF - Journal of Immunology AU - Paintlia, Ajaib S AU - Paintlia, Manjeet K AU - Singh, Inderjit AU - Singh, Avtar K AD - Department of Pediatrics and Department of Pathology and Laboratory Medicine, Medical University of South Carolina and Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC 29425 Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 SP - 4385 EP - 4398 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 176 IS - 7 SN - 0022-1767, 0022-1767 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Cell survival KW - Central nervous system KW - Interleukin 4 KW - Astrocytes KW - Peroxisome proliferator-activated receptors KW - Oligodendrocytes KW - Glial cells KW - Helper cells KW - Arachidonate 12-lipoxygenase KW - Demyelinating diseases KW - NF- Kappa B protein KW - Glial stem cells KW - Inflammatory diseases KW - AKT protein KW - Lymphocytes T KW - MAP kinase KW - Data processing KW - Multiple sclerosis KW - Brain KW - Remission KW - Enzymes KW - Plasmids KW - Inflammation KW - Nitric-oxide synthase KW - siRNA KW - Nitric oxide KW - W 30940:Products KW - F 06326:Multiple Sclerosis: Clinical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20240986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=IL-4-Induced+Peroxisome+Proliferator-Activated+Receptor+gamma+Activation+Inhibits+NF-+Kappa+B+Trans+Activation+in+Central+Nervous+System+%28CNS%29+Glial+Cells+and+Protects+Oligodendrocyte+Progenitors+under+Neuroinflammatory+Disease+Conditions%3A+Implication+for+CNS-Demyelinating+Diseases&rft.au=Paintlia%2C+Ajaib+S%3BPaintlia%2C+Manjeet+K%3BSingh%2C+Inderjit%3BSingh%2C+Avtar+K&rft.aulast=Paintlia&rft.aufirst=Ajaib&rft.date=2006-04-01&rft.volume=176&rft.issue=7&rft.spage=4385&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Central nervous system; Interleukin 4; Oligodendrocytes; Peroxisome proliferator-activated receptors; Astrocytes; Helper cells; Glial cells; Arachidonate 12-lipoxygenase; Demyelinating diseases; NF- Kappa B protein; Glial stem cells; Inflammatory diseases; Lymphocytes T; AKT protein; MAP kinase; Data processing; Multiple sclerosis; Brain; Enzymes; Remission; Plasmids; Inflammation; Nitric-oxide synthase; siRNA; Nitric oxide ER - TY - JOUR T1 - Microarray analysis of gene expression during the inflammation and endochondral bone formation stages of rat femur fracture repair AN - 20078351; 6843080 AB - Microarray analysis of gene expression was performed in the healing femur fractures of 13-week-old male rats during the inflammatory stage of repair, at 3 days post-fracture, and the endochondral bone formation stage of repair, at 11 days post-fracture. Multiple replicate pairs of fracture tissues paired with unfractured tissues, and unfractured control bones that had the stabilizing K-wire were introduced. This approach normalized the marrow contributions to the RNA repertoire. We identified 6555 genes with significant changes in expression in fracture tissues at 3 days and 11 days healing. The repertoire of growth factor genes expressed was also surprisingly restricted at both post-fracture intervals. The large number of Expressed Sequence Tags (ESTs) expressed at both post-fracture times indicates that several molecular pathways yet to be identified regulate fracture repair. The number of genes expressed during immune responses and inflammatory processes was restricted with higher expression largely during the early post-fracture analysis. Several of the genes identified in this study have been associated with regulation of cell and extracellular matrix interactions during scarless healing of fetal skin wounds. These observations suggest that these genes might also regulate the scarless healing characteristic of bone regeneration by similar mechanisms. JF - Bone AU - Rundle, CH AU - Wang, H AU - Yu, H AU - Chadwick, R B AU - Davis, E I AU - Wergedal, JE AU - Lau, KHW AU - Mohan, S AU - Ryaby, J T AU - Baylink, D J AD - Jerry L. Pettis V. A. Medical Center, Loma Linda, CA 92357, USA, William.Lau@med.va.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 521 EP - 529 PB - Elsevier Inc. VL - 38 IS - 4 SN - 8756-3282, 8756-3282 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Skin KW - Fractures KW - Bone growth KW - Femur KW - expressed sequence tags KW - DNA microarrays KW - Fetuses KW - Inflammation KW - Wounds KW - Gene expression KW - Bone healing KW - RNA KW - Extracellular matrix KW - Regeneration KW - Growth factors KW - Immune response KW - Osteogenesis KW - T 20031:Fractures and bone healing KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20078351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bone&rft.atitle=Microarray+analysis+of+gene+expression+during+the+inflammation+and+endochondral+bone+formation+stages+of+rat+femur+fracture+repair&rft.au=Rundle%2C+CH%3BWang%2C+H%3BYu%2C+H%3BChadwick%2C+R+B%3BDavis%2C+E+I%3BWergedal%2C+JE%3BLau%2C+KHW%3BMohan%2C+S%3BRyaby%2C+J+T%3BBaylink%2C+D+J&rft.aulast=Rundle&rft.aufirst=CH&rft.date=2006-04-01&rft.volume=38&rft.issue=4&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Bone&rft.issn=87563282&rft_id=info:doi/10.1016%2Fj.bone.2005.09.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Skin; Bone growth; Fractures; DNA microarrays; expressed sequence tags; Femur; Fetuses; Wounds; Inflammation; Bone healing; Gene expression; RNA; Extracellular matrix; Regeneration; Immune response; Growth factors; Osteogenesis DO - http://dx.doi.org/10.1016/j.bone.2005.09.015 ER - TY - JOUR T1 - Infectious arthritis: clinical features, laboratory findings and treatment AN - 19839662; 6761904 AB - An infection of native joints leads generally to suppurative arthritis, which may be of one joint (monarticular) or several joints (oligoarticular). Bacteria that produce symptoms in multiple joints during bacteraemia, such as Neisseria gonorrhoeae, may also induce inflammation in the neighbouring tendon sheaths. Viral infections frequently involve multiple joints and produce inflammation without suppuration. Chronic granulomatous monarticular arthritis may occur because of infection with either mycobacteria or fungi, which must be differentiated from other causes of chronic monarticular arthritis. A sterile arthritis may occur early in infection (as with hepatitis B), or later (as with a post-infectious arthritis). Any patient presenting with an inflamed joint should have infection as a diagnostic possibility and appropriate cultures must be performed. JF - Clinical Microbiology and Infection AU - Smith, J W AU - Chalupa, P AU - Shabaz Hasan, M AD - University of Texas Southwestern Medical Center Dallas, Department of Medicine, Division of Infectious Diseases, and North Texas Veterans Healthcare Systems, Dallas, TX, USA, jameswilliam.smith@med.va.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 309 EP - 314 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 12 IS - 4 SN - 1198-743X, 1198-743X KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Arthritis KW - bacterial infection KW - fungal infection KW - review KW - viral infection KW - Reviews KW - Fungi KW - Chronic infection KW - Joint diseases KW - Hepatitis B KW - Bacteremia KW - Sheaths KW - Neisseria gonorrhoeae KW - Tendons KW - Inflammation KW - J 02855:Human Bacteriology: Others KW - V 22350:Immunology KW - K 03400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19839662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+and+Infection&rft.atitle=Infectious+arthritis%3A+clinical+features%2C+laboratory+findings+and+treatment&rft.au=Smith%2C+J+W%3BChalupa%2C+P%3BShabaz+Hasan%2C+M&rft.aulast=Smith&rft.aufirst=J&rft.date=2006-04-01&rft.volume=12&rft.issue=4&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+and+Infection&rft.issn=1198743X&rft_id=info:doi/10.1111%2Fj.1469-0691.2006.01366.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - SuppNotes - Tables, 5; references, 24. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Fungi; Reviews; Arthritis; Chronic infection; Hepatitis B; Joint diseases; Bacteremia; Sheaths; Tendons; Inflammation; Neisseria gonorrhoeae DO - http://dx.doi.org/10.1111/j.1469-0691.2006.01366.x ER - TY - JOUR T1 - Unmet medical needs in antibacterial therapy AN - 19769012; 6699430 AB - The innate and evolutionary resourcefulness of bacterial pathogens virtually guarantees that there will always be important areas in which antimicrobial therapy can be improved. Current areas of need, or ones that are anticipated to be problematic in the near future include nosocomial infections caused by multi- resistant Gram-negative bacteria, where the variety and prevalence of multidrug efflux pumps provides a particular challenge to the designers of new drugs. In the community setting, the current prevalence of ampicillin and trimethoprim- sulfamethoxazole resistance, and the growing prevalence of fluoroquinolone resistance in Escherichia coli portend a need for new classes of oral agents to address this important need. On the Gram-positive side, the rapid increase in virulent community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections as a cause of pneumonia emphasizes the importance of developing more agents that are active against MRSA and that are effective for treating pneumonia. Finally, the importance of indwelling devices as a nidus for nosocomial infections emphasizes the need for effective agents for treating biofilm-associated device infection both inside and outside of the hospital. JF - Biochemical Pharmacology AU - Rice, Louis B AD - Louis Stokes Cleveland VA Medical Center and Case Western Reserve University, Medical Service 111(W), 10701 East Blvd., Cleveland, OH 44106, USA, louis.rice@med.va.gov Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 SP - 991 EP - 995 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 71 IS - 7 SN - 0006-2952, 0006-2952 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Antimicrobial agents KW - Efflux pumps KW - Porins KW - Biofilms KW - Resistance KW - Sulfamethoxazole KW - Fluoroquinolones KW - Drug resistance KW - Ampicillin KW - Pathogens KW - Gram-negative bacteria KW - Nosocomial infection KW - Escherichia coli KW - Staphylococcus aureus KW - Pneumonia KW - Evolution KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19769012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Pharmacology&rft.atitle=Unmet+medical+needs+in+antibacterial+therapy&rft.au=Rice%2C+Louis+B&rft.aulast=Rice&rft.aufirst=Louis&rft.date=2006-03-30&rft.volume=71&rft.issue=7&rft.spage=991&rft.isbn=&rft.btitle=&rft.title=Biochemical+Pharmacology&rft.issn=00062952&rft_id=info:doi/10.1016%2Fj.bcp.2005.09.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Fluoroquinolones; Sulfamethoxazole; Drug resistance; Gram-negative bacteria; Nosocomial infection; Ampicillin; Pathogens; Evolution; Pneumonia; Antimicrobial agents; Hospitals; Escherichia coli; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.bcp.2005.09.018 ER - TY - JOUR T1 - Sustained virological response rates and health-related quality of life after interferon and ribavirin therapy in patients with chronic hepatitis C virus infection and persistently normal alanine aminotransferase levels. AN - 67775667; 16556180 AB - Few studies have evaluated interferon and ribavirin therapy in hepatitis C virus-infected patients with persistently normal alanine aminotransferase (ALT) levels. To determine the efficacy and safety of combination therapy in this population, and to evaluate the impact of treatment on health-related quality of life. Forty-six hepatitis C virus-infected patients with persistently normal ALT levels and 92 matched subjects with elevated ALT levels were treated with interferon-alpha2b plus ribavirin for up to 48 weeks. Health-related quality of life was measured prior to therapy and 24 weeks after completion of treatment using the Hepatitis Quality of Life Questionnaire. Overall, 32.6% of patients with normal ALT levels and 28.3% of those with elevated ALT levels had undetectable hepatitis C virus RNA at 24 weeks after completion of treatment (P = 0.60). Three patients in the normal ALT group had mild transient ALT elevations during therapy. Compared with baseline, treatment was associated with significant improvements in nearly all domains of health-related quality of life in both groups of patients. In hepatitis C virus-infected patients with persistently normal ALT levels, interferon-alpha and ribavirin therapy is efficacious, safe, and associated with significant improvements in health-related quality of life. JF - Alimentary pharmacology & therapeutics AU - Bini, E J AU - Mehandru, S AD - Department of Medicine and Division of Gastroenterology, VA New York Harbor Healthcare System and NYU School of Medicine, New York, NY 10010, USA. edmund.bini@med.va.gov Y1 - 2006/03/15/ PY - 2006 DA - 2006 Mar 15 SP - 777 EP - 785 VL - 23 IS - 6 SN - 0269-2813, 0269-2813 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - RNA, Viral KW - Recombinant Proteins KW - interferon alfa-2b KW - 43K1W2T1M6 KW - Ribavirin KW - 49717AWG6K KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Genotype KW - Drug Therapy, Combination KW - Hepacivirus -- genetics KW - Humans KW - Hepacivirus -- isolation & purification KW - Treatment Outcome KW - Middle Aged KW - Male KW - Hepacivirus -- drug effects KW - Female KW - RNA, Viral -- analysis KW - Antiviral Agents -- therapeutic use KW - Ribavirin -- therapeutic use KW - Interferon-alpha -- therapeutic use KW - Interferon-alpha -- adverse effects KW - Hepatitis C -- virology KW - Hepatitis C -- drug therapy KW - Alanine Transaminase -- blood KW - Hepatitis C -- blood KW - Quality of Life KW - Antiviral Agents -- adverse effects KW - Ribavirin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67775667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alimentary+pharmacology+%26+therapeutics&rft.atitle=Sustained+virological+response+rates+and+health-related+quality+of+life+after+interferon+and+ribavirin+therapy+in+patients+with+chronic+hepatitis+C+virus+infection+and+persistently+normal+alanine+aminotransferase+levels.&rft.au=Bini%2C+E+J%3BMehandru%2C+S&rft.aulast=Bini&rft.aufirst=E&rft.date=2006-03-15&rft.volume=23&rft.issue=6&rft.spage=777&rft.isbn=&rft.btitle=&rft.title=Alimentary+pharmacology+%26+therapeutics&rft.issn=02692813&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-29 N1 - Date created - 2006-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Pregnancy Complications as Risk Factors for Cardiac and All-Cause Mortality T2 - 55th Annual Scientific Session of the American College of Cardiology AN - 40151608; 4156297 JF - 55th Annual Scientific Session of the American College of Cardiology AU - Biswas, Mimi S AU - Chireau, Monique AU - Honeycutt, Emily F AU - Brown, Haywood AU - Newby, L Kristin AU - Bastian, Lori A Y1 - 2006/03/11/ PY - 2006 DA - 2006 Mar 11 KW - Mortality KW - Pregnancy complications KW - Heart KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40151608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.atitle=Pregnancy+Complications+as+Risk+Factors+for+Cardiac+and+All-Cause+Mortality&rft.au=Biswas%2C+Mimi+S%3BChireau%2C+Monique%3BHoneycutt%2C+Emily+F%3BBrown%2C+Haywood%3BNewby%2C+L+Kristin%3BBastian%2C+Lori+A&rft.aulast=Biswas&rft.aufirst=Mimi&rft.date=2006-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B47BF60AC-8EA4-4311-9EB4-E9AC 186092DC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The CYBA Genotype is Associated with Altered NADPH Oxidase Activity in Patients with Cardiovascular Disease T2 - 55th Annual Scientific Session of the American College of Cardiology AN - 40093216; 4154514 JF - 55th Annual Scientific Session of the American College of Cardiology AU - Wang, Shaoshan S AU - Mehranpour, Payam AU - Li, Wei AU - Dikalov, Sergey AU - Austin, Harland AU - Zafari, A Maziar Y1 - 2006/03/11/ PY - 2006 DA - 2006 Mar 11 KW - Cardiovascular diseases KW - NADPH oxidase KW - Genotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40093216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.atitle=The+CYBA+Genotype+is+Associated+with+Altered+NADPH+Oxidase+Activity+in+Patients+with+Cardiovascular+Disease&rft.au=Wang%2C+Shaoshan+S%3BMehranpour%2C+Payam%3BLi%2C+Wei%3BDikalov%2C+Sergey%3BAustin%2C+Harland%3BZafari%2C+A+Maziar&rft.aulast=Wang&rft.aufirst=Shaoshan&rft.date=2006-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B47BF60AC-8EA4-4311-9EB4-E9AC 186092DC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Anticholinergic agents in asthma and COPD. AN - 67723907; 16488410 AB - Anticholinergic agents have important uses as bronchodilators for the treatment of obstructive airway diseases, both asthma and, more particularly, chronic obstructive pulmonary disease (COPD). Those in approved clinical use are synthetic quaternary ammonium congeners of atropine, and include ipratropium bromide, oxitropium bromide, and tiotropium bromide, each of which is very poorly absorbed when given by inhalation. Ipratropium and oxitropium have relatively short durations of action (4-8 h). They have been widely used for many years, either alone or in combination with short-acting beta-adrenergic agents such as albuterol and fenoterol, for both maintenance treatment of stable disease and for acute exacerbations of airway obstruction. Tiotropium, which was introduced in the early 2000s, has a duration of action of at least 1-2 days making it suitable for once-daily maintenance treatment of COPD. All of the above agents have a wide therapeutic margin and are safe and well tolerated by patients. JF - European journal of pharmacology AU - Gross, Nicholas J AD - Stritch-Loyola School of Medicine, Voluntary Attending Physician, Hines VA Hospital, Chicago, Hines, IL 60141, USA. Nicholas.gross@med.va.gov Y1 - 2006/03/08/ PY - 2006 DA - 2006 Mar 08 SP - 36 EP - 39 VL - 533 IS - 1-3 SN - 0014-2999, 0014-2999 KW - Bronchodilator Agents KW - 0 KW - Cholinergic Antagonists KW - Scopolamine Derivatives KW - oxitropium KW - 8G15T83E6I KW - Ipratropium KW - GR88G0I6UL KW - Tiotropium Bromide KW - XX112XZP0J KW - Index Medicus KW - Ipratropium -- adverse effects KW - Scopolamine Derivatives -- therapeutic use KW - Humans KW - Scopolamine Derivatives -- adverse effects KW - Clinical Trials as Topic KW - Ipratropium -- therapeutic use KW - Asthma -- drug therapy KW - Bronchodilator Agents -- therapeutic use KW - Cholinergic Antagonists -- therapeutic use KW - Pulmonary Disease, Chronic Obstructive -- drug therapy KW - Cholinergic Antagonists -- adverse effects KW - Bronchodilator Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67723907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Anticholinergic+agents+in+asthma+and+COPD.&rft.au=Gross%2C+Nicholas+J&rft.aulast=Gross&rft.aufirst=Nicholas&rft.date=2006-03-08&rft.volume=533&rft.issue=1-3&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-11 N1 - Date created - 2006-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A Study of the Association between Retrospective Appraisal of Childhood Reactivity and Post-Discharge Traumatic Stress in Combat Veterans AN - 877592337; 13617237 AB - A small-scale exploratory study (Ginsberg, Ayers, Burriss, & Powell, 2004) was extended to include additional participants. Results of the two studies showed a high degree of agreement and, taken together, indicate that retrospective appraisal of low magnitude adverse experiences in childhood (before age 17) may be significantly associated with post-discharge traumatic stress (PTS) in combat veterans. The number of adverse childhood experiences per individual veteran was not found to be significantly associated with PTS or other psychological outcome (state anxiety, trait anxiety, or depression). However, ratings of fear of physical effects from childhood adversity were positively and significantly correlated with PTS, and of equal significance with combat exposure in explaining PTS variance. Increased ratings of fear of childhood adversity also were significantly associated with chronicity of PTS in all participants. These results support a conclusion that retrospectively assessed childhood reactivity may represent a marker of vulnerability to chronic PTS among veterans. Further research that overcomes methodological weaknesses, explores possible mechanisms of instatement of childhood reactivity, and elaborates the relationship between reactivity and stable personality traits is needed. Practice implications manifestly include assessment and prognostication of chronic traumatic stress reactions as well as sensitivity to and incorporation of early life issues into treatment approaches. JF - Traumatology AU - Ginsberg, J P AU - Ayres, ED AU - Burriss, L B AU - Powell, DA AD - Neurobiology and PTSD Program, Shirley L. Buchanan Neuroscience Lab, Dorn VAMC, Columbia, SC, jay.ginsberg@med.va.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 61 EP - 82 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 12 IS - 1 SN - 1534-7656, 1534-7656 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877592337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traumatology&rft.atitle=A+Study+of+the+Association+between+Retrospective+Appraisal+of+Childhood+Reactivity+and+Post-Discharge+Traumatic+Stress+in+Combat+Veterans&rft.au=Ginsberg%2C+J+P%3BAyres%2C+ED%3BBurriss%2C+L+B%3BPowell%2C+DA&rft.aulast=Ginsberg&rft.aufirst=J&rft.date=2006-03-01&rft.volume=12&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Traumatology&rft.issn=15347656&rft_id=info:doi/10.1177%2F153476560601200105 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1177/153476560601200105 ER - TY - JOUR T1 - Homogeneity of the 18 QuickSIN lists. AN - 85386454; pmid-16646276 AB - The purpose of this study was to determine the list equivalency of the 18 QuickSIN (Quick Speech in Noise test) lists. Individuals with normal hearing (n = 24) and with sensorineural hearing loss (n = 72) were studied. Mean recognition performances on the 18 lists by the listeners with normal hearing were 2.8 to 4.3 dB SNR (signal-to-noise ratio), whereas the range was 10.0 to 14.3 dB SNR for the listeners with hearing loss. The psychometric functions for each list showed high performance variability across lists for listeners with hearing loss but not for listeners with normal hearing. For listeners with hearing loss, Lists 4, 5, 13, and 16 fell outside of the critical difference. The data from this study suggest nine lists that provide homogenous results for listeners with and without hearing loss. Finally, there was an 8.7 dB difference in performances between the two groups indicating a more favorable signal-to-noise ratio required by the listeners with hearing loss to obtain equal performance. JF - Journal of the American Academy of Audiology AU - McArdle, Rachel A AU - Wilson, Richard H AD - The Bay Pines VA Healthcare System, Bay Pines, Florida 33744, USA. Rachel.mcardle@med.va.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 157 EP - 167 VL - 17 IS - 3 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Acoustic Stimulation KW - Adult KW - Age Factors KW - Aged KW - *Audiometry, Speech: methods KW - Female KW - *Hearing Loss, High-Frequency: diagnosis KW - *Hearing Loss, Sensorineural: diagnosis KW - Humans KW - Male KW - *Noise: adverse effects KW - Sensitivity and Specificity KW - *Speech Perception: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85386454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Organization+of+the+membrane+domain+of+the+human+liver+sodium%2Fbile+acid+cotransporter.&rft.au=Hall%C3%A9n%2C+S%3BMareninova%2C+O%3BBr%C3%A4nd%C3%A9n%2C+M%3BSachs%2C+G&rft.aulast=Hall%C3%A9n&rft.aufirst=S&rft.date=2002-06-11&rft.volume=41&rft.issue=23&rft.spage=7253&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: J Am Acad Audiol. 2006 Sep;17(8):617-8[16999256] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Practical and theoretical considerations in designing rehabilitation trials: the DVBIC cognitive-didactic versus functional-experiential treatment study experience. AN - 85385468; pmid-16569991 AB - This is a descriptive article outlining issues in the development and implementation of a multisite randomized rehabilitation trial for brain injury treatment. The goal of this article is to present practical and theoretical considerations in designing and conducting multicenter rehabilitation trials. Practical issues discussed include (a) treatment setting, (b) patient accessibility in determining the research question of interest, as well as inclusion and exclusion criteria, (c) research protocol development in the context of rehabilitation standard of care, and (d) protocol treatments in the context of realistic cost-benefits analysis. Rehabilitation theory is discussed as playing an important role designing the specifics of the protocol interventions. The Defense and Veterans Brain Injury Center Veterans Health Administration cognitive-didactic versus functional-experiential study methodology is used for illustrative purposes. This study evaluated 2 alternative approaches to treatment: one focusing on underlying cognitive processes and the second on errorless learning in everyday functional situations. Lessons learned over the course of completing the treatment trial are discussed. JF - The Journal of head trauma rehabilitation AU - Vanderploeg, Rodney D AU - Collins, Rose C AU - Sigford, Barbara AU - Date, Elaine AU - Schwab, Karen AU - Warden, Deborah AD - James A. Haley Veterans Affairs Medical Center, FL 33612, USA. rodney.vanderploeg@va.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 179 EP - 193 VL - 21 IS - 2 SN - 0885-9701, 0885-9701 KW - Index Medicus KW - National Library of Medicine KW - *Brain Injuries: rehabilitation KW - Clinical Protocols KW - *Cognitive Therapy KW - Humans KW - Patient Selection KW - *Randomized Controlled Trials as Topic: methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85385468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+head+trauma+rehabilitation&rft.atitle=Practical+and+theoretical+considerations+in+designing+rehabilitation+trials%3A+the+DVBIC+cognitive-didactic+versus+functional-experiential+treatment+study+experience.&rft.au=Vanderploeg%2C+Rodney+D%3BCollins%2C+Rose+C%3BSigford%2C+Barbara%3BDate%2C+Elaine%3BSchwab%2C+Karen%3BWarden%2C+Deborah&rft.aulast=Vanderploeg&rft.aufirst=Rodney&rft.date=2006-03-01&rft.volume=21&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+head+trauma+rehabilitation&rft.issn=08859701&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Sleep quality and the role of sleep medications for veterans with chronic pain. AN - 67900954; 16634723 AB - The purpose of this study was to investigate the nature of sleep problems in veterans presenting to a pain clinic, factors that predict likelihood of being prescribed a sleep medication, types of medications prescribed, and the relationships between sleep medication use and sleep quality, pain, and depression. Participants were 201 consecutive patients referred to a Veterans Affairs outpatient pain clinic. They were administered the Pittsburgh Sleep Quality Index, Multidimensional Pain Inventory, and Beck Depression Inventory at intake and 2-month follow-up. Sleep and opioid medication prescriptions were also monitored. Pain severity did not predict global sleep quality; global sleep quality was not predictive of pain severity. Greater depression predicted both more severe pain and more sleep impairment. Having previously been prescribed such medications was the only significant predictor of being prescribed a sleep medication at the time of the 2-month assessment. For the 45% of participants on sleep medications, these medications were not associated with any significant change in pain factors or depression. However, sleep medication use was associated with worse global sleep quality, sleep duration, and sleep efficiency. Opioid prescription was not a significant predictor of sleep factors, pain-related variables, or depression symptoms. Results suggest depression may contribute more significantly to sleep problems than pain-related variables in this population. The data suggest the need for controlled, prospective studies of sleep medication to further investigate the impact of sleep medications on sleep components in patients with chronic pain. JF - Pain medicine (Malden, Mass.) AU - Chapman, Judith B AU - Lehman, Cassandra L AU - Elliott, Janette AU - Clark, J David AD - Psychology Service--116B, Department of Veterans Affairs, Palo Alto Health Care System, 3801 Miranda Avenue, California 94304, USA. judith.chapman@med.va.gov PY - 2006 SP - 105 EP - 114 VL - 7 IS - 2 SN - 1526-2375, 1526-2375 KW - Hypnotics and Sedatives KW - 0 KW - Narcotics KW - Index Medicus KW - Sleep -- physiology KW - Humans KW - Aged KW - Narcotics -- adverse effects KW - Pain Measurement KW - Predictive Value of Tests KW - Sleep -- drug effects KW - Aged, 80 and over KW - Adult KW - Pain Threshold -- drug effects KW - Treatment Outcome KW - Surveys and Questionnaires KW - Chronic Disease -- drug therapy KW - Middle Aged KW - Pain Threshold -- physiology KW - Neuropsychological Tests KW - Female KW - Male KW - Pain, Intractable -- psychology KW - Hypnotics and Sedatives -- therapeutic use KW - Veterans -- statistics & numerical data KW - Sleep Wake Disorders -- drug therapy KW - Depressive Disorder -- psychology KW - Depressive Disorder -- etiology KW - Veterans -- psychology KW - Sleep Wake Disorders -- psychology KW - Sleep Wake Disorders -- etiology KW - Pain, Intractable -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67900954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain+medicine+%28Malden%2C+Mass.%29&rft.atitle=Sleep+quality+and+the+role+of+sleep+medications+for+veterans+with+chronic+pain.&rft.au=Chapman%2C+Judith+B%3BLehman%2C+Cassandra+L%3BElliott%2C+Janette%3BClark%2C+J+David&rft.aulast=Chapman&rft.aufirst=Judith&rft.date=2006-03-01&rft.volume=7&rft.issue=2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Pain+medicine+%28Malden%2C+Mass.%29&rft.issn=15262375&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-09 N1 - Date created - 2006-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Geriatric alcoholism: pathophysiology and dental implications. AN - 67807652; 16570466 AB - The authors reviewed the clinical features, epidemiology, diagnosis, medical treatment, orofacial findings and dental treatment of geriatric patients with alcoholism. The authors conducted MEDLINE searches for the period 1995 through 2004 using the terms "alcoholism," "geriatric," "pathophysiology," "treatment" and "dentistry." They selected reports published in English in peer-reviewed journals for further review. Physiological changes associated with aging permit the harmful effects of drinking alcohol to arise at lower levels of consumption than in younger people. Excessive use of alcohol exacerbates the medical and emotional problems associated with aging and predisposes the person to adverse drug reactions with medications controlling these illnesses. The incidence of dental disease in this population is extensive because of diminished salivary flow and a disinterest in performing appropriate oral hygiene techniques. Concurrent abuse of tobacco products worsens dental disease and heightens the risk of developing oral cancer. Identification of patients who abuse alcohol, a cancer-screening examination, preventive dental education, and use of saliva substitutes and anticaries agents are indicated. Clinicians must take precautions when performing surgery and when prescribing or administering analgesics, antibiotics or sedative agents that are likely to have an adverse interaction with alcohol. JF - Journal of the American Dental Association (1939) AU - Friedlander, Arthur H AU - Norman, Dean C AD - VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, Calif. 90073, USA. friedlander@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 330 EP - 338 VL - 137 IS - 3 SN - 0002-8177, 0002-8177 KW - Dentistry KW - Index Medicus KW - Age Factors KW - Humans KW - Aging KW - Aged KW - Alcoholism -- epidemiology KW - Alcoholic Beverages -- adverse effects KW - Dental Care for Aged -- methods KW - Alcoholism -- physiopathology KW - Mouth Diseases -- etiology KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67807652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Geriatric+alcoholism%3A+pathophysiology+and+dental+implications.&rft.au=Friedlander%2C+Arthur+H%3BNorman%2C+Dean+C&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2006-03-01&rft.volume=137&rft.issue=3&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-16 N1 - Date created - 2006-03-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Opioid substitution treatment reduces substance use equivalently in patients with and without posttraumatic stress disorder. AN - 67783021; 16562404 AB - The purpose of this study was to determine whether opioid-dependent patients with diagnosed posttraumatic stress disorder (PTSD) have poorer long-term outcomes in opioid substitution treatment than do patients without PTSD. This prospective observational study examined outcomes of 255 opioid-dependent patients (men = 248) entering opioid substitution treatment at eight clinics in the Veterans Health Administration (VHA). Subjects were interviewed at treatment entry, 6 months, and 1 year about substance use and related problems, health status, treatment satisfaction, and non-VHA health care utilization. Medical records were reviewed to obtain toxicology results, health care utilization data, and diagnoses. Medical record review identified a diagnosis of PTSD in 71 (28%) patients. Substance-use and mental-health outcomes and health care utilization in the first year following treatment entry were compared between patients with and without a diagnosis of PTSD. Patients with and without PTSD had similar treatment responses. Although patients with PTSD had longer histories of drug use at intake, at 1-year follow-up they showed reductions in heroin, cocaine, and alcohol use, comparable to patients without the disorder. PTSD patients received higher doses of opiate medication, attended more psychosocial treatment sessions for substance-use disorder, and had better treatment retention. Psychiatric symptoms for patients with PTSD were more severe at intake and showed little improvement throughout treatment. Opioid substitution therapy is as effective at reducing substance use in PTSD patients as it is in patients without the disorder, but additional services are needed for treatment of psychological problems that are largely unchanged by treatment for addiction. JF - Journal of studies on alcohol AU - Trafton, Jodie A AU - Minkel, Jared AU - Humphreys, Keith AD - Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System, California, USA. Jodie.Trafton@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 228 EP - 235 VL - 67 IS - 2 SN - 0096-882X, 0096-882X KW - Narcotics KW - 0 KW - Street Drugs KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Alcoholism -- rehabilitation KW - Humans KW - Cocaine-Related Disorders -- psychology KW - Prognosis KW - Aged KW - Cocaine-Related Disorders -- epidemiology KW - Alcoholism -- psychology KW - Comorbidity KW - Health Status Indicators KW - Alcoholism -- epidemiology KW - Heroin Dependence -- epidemiology KW - Substance Abuse Detection KW - Risk Factors KW - Marijuana Abuse -- rehabilitation KW - Adult KW - Treatment Outcome KW - Heroin Dependence -- rehabilitation KW - Middle Aged KW - Marijuana Abuse -- psychology KW - Marijuana Abuse -- epidemiology KW - Follow-Up Studies KW - Heroin Dependence -- psychology KW - Male KW - Female KW - Opioid-Related Disorders -- epidemiology KW - Combat Disorders -- psychology KW - Opioid-Related Disorders -- psychology KW - Veterans -- psychology KW - Opioid-Related Disorders -- rehabilitation KW - Narcotics -- administration & dosage KW - Combat Disorders -- rehabilitation KW - Methadone -- administration & dosage KW - Combat Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67783021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.atitle=Lexical+and+talker+effects+on+word+recognition+among+native+and+non-native+listeners+with+normal+and+impaired+hearing.&rft.au=Takayanagi%2C+Sumiko%3BDirks%2C+Donald+D%3BMoshfegh%2C+Anahita&rft.aulast=Takayanagi&rft.aufirst=Sumiko&rft.date=2002-06-01&rft.volume=45&rft.issue=3&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.issn=10924388&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-08 N1 - Date created - 2006-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The cost-effectiveness of strategies to reduce mortality from an intentional release of aerosolized anthrax spores. AN - 67733999; 16525172 AB - Intentional exposures to aerosolized Bacillus anthracis spores have caused fatalities. To evaluate the cost-effectiveness of strategies to reduce mortality from future inhalational anthrax exposures. Computer cohort simulation of a 100,000-person single-site exposure (worst-case scenario) and a 100-person multiple-site exposure (resembling the recent US attack). For each scenario, universal vaccination and an emergency surveillance and response (ESR) system were compared with a default strategy that assumed eventual discovery of the exposure. If an exposure was unlikely to occur or was small in scale, neither vaccination nor an ESR system was cost-effective. If an exposure was certain and large in scale, an ESR system was more cost-effective than vaccination ($73 v. $29,600 per life-year saved), and a rapid response saved more lives than improved surveillance. Strategies to reduce deaths from anthrax attacks are cost-effective only if large exposures are certain. A faster response is more beneficial than enhanced surveillance. JF - Medical decision making : an international journal of the Society for Medical Decision Making AU - Braithwaite, R Scott AU - Fridsma, Douglas AU - Roberts, Mark S AD - Section of General Internal Medicine, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA. ronald.braithwaite@med.va.gov PY - 2006 SP - 182 EP - 193 VL - 26 IS - 2 SN - 0272-989X, 0272-989X KW - Aerosol Propellants KW - 0 KW - Index Medicus KW - Computer Simulation KW - Inhalation Exposure KW - Humans KW - Emergency Medical Services -- economics KW - Cost-Benefit Analysis KW - Bacillus anthracis -- pathogenicity KW - Vaccination KW - United States -- epidemiology KW - Population Surveillance KW - Bioterrorism -- economics KW - Anthrax -- prevention & control KW - Anthrax -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67733999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+decision+making+%3A+an+international+journal+of+the+Society+for+Medical+Decision+Making&rft.atitle=The+cost-effectiveness+of+strategies+to+reduce+mortality+from+an+intentional+release+of+aerosolized+anthrax+spores.&rft.au=Braithwaite%2C+R+Scott%3BFridsma%2C+Douglas%3BRoberts%2C+Mark+S&rft.aulast=Braithwaite&rft.aufirst=R&rft.date=2006-03-01&rft.volume=26&rft.issue=2&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Medical+decision+making+%3A+an+international+journal+of+the+Society+for+Medical+Decision+Making&rft.issn=0272989X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-16 N1 - Date created - 2006-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Management of hepatitis C disease among VA patients with schizophrenia and substance use disorders. AN - 67729954; 16525001 AB - Rates of hepatitis C (HCV) infection, testing, and treatment were compared among patients with schizophrenia, a substance use disorder, or co-occurring schizophrenia or schizoaffective disorder and a substance use disorder and a control group. Information about 293,445 patients of the Northwest Veterans Healthcare Administration was obtained. The substance use disorder group constituted 13.6 percent of the sample; the schizophrenia group, 1.6 percent; and the co-occurring-disorders group, 1.4 percent. Respectively, these groups were approximately four, two, and six times as likely as the control group to receive HCV testing and about seven, two, and eight times as likely to be infected. The rate of interferon (IFN) therapy was significantly lower for the substance use group and the group with co-occurring disorders. However, the magnitude of the differences was not substantial, suggesting that these high-risk groups were not excluded from IFN therapy. JF - Psychiatric services (Washington, D.C.) AU - Huckans, Marilyn S AU - Blackwell, Aaron D AU - Harms, Todd A AU - Hauser, Peter AD - Northwest Hepatitis C Resource Center, Portland Veterans Affairs Medical Center, and Department of Psychiatry at Oregon Health and Science University 97239, USA. marilyn.huckans@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 403 EP - 406 VL - 57 IS - 3 SN - 1075-2730, 1075-2730 KW - Interferons KW - 9008-11-1 KW - Index Medicus KW - United States KW - Oregon KW - United States Department of Veterans Affairs KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Schizophrenic Psychology KW - Psychotic Disorders -- diagnosis KW - Veterans KW - Hepatitis C -- drug therapy KW - Hepatitis C -- diagnosis KW - Substance-Related Disorders -- drug therapy KW - Schizophrenia -- diagnosis KW - Schizophrenia -- drug therapy KW - Substance-Related Disorders -- psychology KW - Interferons -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67729954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Management+of+hepatitis+C+disease+among+VA+patients+with+schizophrenia+and+substance+use+disorders.&rft.au=Huckans%2C+Marilyn+S%3BBlackwell%2C+Aaron+D%3BHarms%2C+Todd+A%3BHauser%2C+Peter&rft.aulast=Huckans&rft.aufirst=Marilyn&rft.date=2006-03-01&rft.volume=57&rft.issue=3&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sodium oxybate for cataplexy. AN - 67729651; 16507620 AB - To review the pharmacology, pharmacokinetics, clinical efficacy, adverse effects, drug interactions, precautions, dosing recommendations, and patient counseling of sodium oxybate for the treatment of cataplexy in patients with narcolepsy. OVID and PubMed databases were searched (1966-January 2006) using the key words sodium oxybate, gamma-hydroxybutyrate, narcolepsy, and cataplexy. Only English-language articles were selected. All information on sodium oxybate related to narcolepsy and cataplexy was considered. Study selection included human trials evaluating safety and efficacy of sodium oxybate for the treatment of cataplexy. Sodium oxybate is approved by the Food and Drug Administration for the treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy. In placebo-controlled trials, sodium oxybate demonstrated efficacy in reducing the number of cataplexy attacks. The dosing regimen includes a split dose given at bedtime and 2.5-4 hours later due to its short elimination half-life. The drug is generally well tolerated, with headache, nausea, dizziness, pain, and somnolence being the most common adverse events. Sodium oxybate is safe and effective for the treatment of cataplexy. Potential disadvantages include a multiple dosing regimen, abuse potential, cost, and a closed distribution system. Potential advantages demonstrated in clinical trials include significant decreases in the number of weekly cataplexy attacks, improvement in daytime sleepiness, and improvement in the Clinical Global Impression of Change score and nighttime awakenings. Overall, sodium oxybate provides a new option for the treatment of cataplexy. JF - The Annals of pharmacotherapy AU - Lemon, Michael D AU - Strain, Joe D AU - Farver, Debra K AD - College of Pharmacy, South Dakota State University; Veterans Affairs Black Hills Health Care System, Fort Meade, 57741, USA. Michael.lemon@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 433 EP - 40; quiz 581-2 VL - 40 IS - 3 SN - 1060-0280, 1060-0280 KW - Sodium Oxybate KW - 7G33012534 KW - Index Medicus KW - Sleep -- drug effects KW - Humans KW - Databases, Factual KW - Clinical Trials as Topic KW - Narcolepsy -- complications KW - Cataplexy -- drug therapy KW - Sodium Oxybate -- therapeutic use KW - Cataplexy -- complications KW - Sodium Oxybate -- pharmacokinetics KW - Sodium Oxybate -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67729651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Sodium+oxybate+for+cataplexy.&rft.au=Lemon%2C+Michael+D%3BStrain%2C+Joe+D%3BFarver%2C+Debra+K&rft.aulast=Lemon&rft.aufirst=Michael&rft.date=2006-03-01&rft.volume=40&rft.issue=3&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-26 N1 - Date created - 2006-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quetiapine for insomnia associated with refractory depression exacerbated by phenelzine. AN - 67729149; 16478812 AB - To report the successful treatment of phenelzine-associated insomnia with low-dose quetiapine in a patient with refractory depression. A 42-year-old white man with severe major depression unresponsive to selective serotonin-reuptake inhibitors, bupropion, and tricyclic antidepressants improved following treatment with the monoamine oxidase inhibitor (MAOI) phenelzine. Insomnia, present to a moderate degree prior to antidepressant therapy, worsened markedly following phenelzine treatment and failed to respond to diphenhydramine, temazepam, triazolam, clonazepam, zolpidem, or trazodone given at high therapeutic doses. Sleep disturbance resolved with low-dose (50 mg) adjunctive quetiapine, with no adverse effects. Major depression refractory to standard therapy is a common and serious condition. Some cases respond to MAOIs; however, orthostatic hypotension and insomnia frequently occur. Potentially serious MAOI interactions with psychotropic drugs have raised concerns about combining these agents. In this case, a failure of a number of other medications known to treat MAOI-associated insomnia safely prompted a trial of quetiapine. Despite the possibility that enhanced serotonergic activity might have resulted in serotonin syndrome, no adverse interactions between phenelzine and quetiapine were noted. The use of low-dose, once-daily quetiapine, along with its unique binding properties, may account for its increased safety in combination with phenelzine. This case illustrates that low-dose quetiapine may be an alternative treatment for phenelzine-associated insomnia. Further case reports are needed to establish the safety and effectiveness of combining these agents. JF - The Annals of pharmacotherapy AU - Sokolski, Kenneth N AU - Brown, Brenda J AD - Mood Disorders Clinic, Veterans Affairs Long Beach Healthcare System, Long Beach, CA 90822, USA. kenneth.sokolski@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 567 EP - 570 VL - 40 IS - 3 SN - 1060-0280, 1060-0280 KW - Antipsychotic Agents KW - 0 KW - Dibenzothiazepines KW - Monoamine Oxidase Inhibitors KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Phenelzine KW - O408N561GF KW - Index Medicus KW - Humans KW - Adult KW - Male KW - Phenelzine -- adverse effects KW - Monoamine Oxidase Inhibitors -- adverse effects KW - Sleep Initiation and Maintenance Disorders -- drug therapy KW - Depressive Disorder, Major -- complications KW - Antipsychotic Agents -- therapeutic use KW - Sleep Initiation and Maintenance Disorders -- chemically induced KW - Dibenzothiazepines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67729149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Quetiapine+for+insomnia+associated+with+refractory+depression+exacerbated+by+phenelzine.&rft.au=Sokolski%2C+Kenneth+N%3BBrown%2C+Brenda+J&rft.aulast=Sokolski&rft.aufirst=Kenneth&rft.date=2006-03-01&rft.volume=40&rft.issue=3&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-26 N1 - Date created - 2006-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pretreatment and during treatment risk factors for dropout among patients with substance use disorders. AN - 67698685; 15979244 AB - The aim of this study was to use pretreatment and treatment factors to predict dropout from residential substance use disorder program and to examine how the treatment environment modifies the risk for dropout. This study assessed 3649 male patients at entry to residential substance use disorder treatment and obtained information about their perceptions of the treatment environment. Baseline factors that predicted dropout included younger age, greater cognitive dysfunction, more drug use, and lower severity of alcohol dependence. Patients in treatment environments appraised as low in support or high in control also were more likely to drop out. Further, patients at high risk of dropout were especially likely to dropout when treated in a highly controlling treatment environment. Better screening of risk factors for dropout and efforts to create a less controlling treatment environment may result in increased retention in substance use disorder treatment. JF - Addictive behaviors AU - McKellar, John AU - Kelly, John AU - Harris, Alex AU - Moos, Rudolf AD - Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System and Stanford University School of Medicine, (152), 795 Willow Road, Menlo Park, CA 94025, USA. John.McKellar@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 450 EP - 460 VL - 31 IS - 3 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Patient Satisfaction KW - Logistic Models KW - Risk Factors KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Predictive Value of Tests KW - Middle Aged KW - Male KW - Social Environment KW - Patient Dropouts -- statistics & numerical data KW - Patient Dropouts -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67698685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Pretreatment+and+during+treatment+risk+factors+for+dropout+among+patients+with+substance+use+disorders.&rft.au=McKellar%2C+John%3BKelly%2C+John%3BHarris%2C+Alex%3BMoos%2C+Rudolf&rft.aulast=McKellar&rft.aufirst=John&rft.date=2006-03-01&rft.volume=31&rft.issue=3&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-13 N1 - Date created - 2006-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gatifloxacin interference with opiate urine drug screen. AN - 67697521; 16503726 AB - A 48-year-old man participating in a residential treatment program was treated with gatifloxacin for a urinary tract infection. While taking the antibiotic, two urine screens were positive for opiates; results of previous urine opiate screens had been negative. Confirmatory tests using a different assay method, however, gave negative results for opiates. Two weeks after completing gatifloxacin therapy, the patient's urine screen was negative for opiates. Application of the Naranjo adverse drug reaction probability scale indicated that gatifloxacin probably was associated with this patient's positive urine opiate screen. Fluoroquinolones as a class are among several compounds that have demonstrated a propensity to cross-react with enzyme immunoassay urine drug screens for opiates. Occurrence of cross-reactivity appears to vary among individual assays. The mechanism by which fluoroquinolones cross-react with the immunoassay is unknown. Falsepositive results could have negative effects on patient care, and ramifications of a positive drug screen include possible dismissal from a substance abuse treatment program. Confirmatory analysis using a different assay method is therefore necessary to verify the presence of the target drug. JF - Pharmacotherapy AU - Straley, Craig M AU - Cecil, Eric J AU - Herriman, Mark P AD - Department of Pharmacy Practice, College of Pharmacy, Ferris State University, Big Rapids, Michigan, USA. craig.straley@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 435 EP - 439 VL - 26 IS - 3 SN - 0277-0008, 0277-0008 KW - Anti-Bacterial Agents KW - 0 KW - Fluoroquinolones KW - Narcotics KW - gatifloxacin KW - L4618BD7KJ KW - Index Medicus KW - Urinary Tract Infections -- drug therapy KW - Anti-Bacterial Agents -- therapeutic use KW - Humans KW - Gas Chromatography-Mass Spectrometry KW - Opioid-Related Disorders -- rehabilitation KW - Opioid-Related Disorders -- urine KW - Male KW - Immunoassay KW - False Positive Reactions KW - Fluoroquinolones -- therapeutic use KW - Narcotics -- urine KW - Substance Abuse Detection -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67697521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Gatifloxacin+interference+with+opiate+urine+drug+screen.&rft.au=Straley%2C+Craig+M%3BCecil%2C+Eric+J%3BHerriman%2C+Mark+P&rft.aulast=Straley&rft.aufirst=Craig&rft.date=2006-03-01&rft.volume=26&rft.issue=3&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-01 N1 - Date created - 2006-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential effects of alcohol consumption and withdrawal on circadian temperature and activity rhythms in Sprague-Dawley, Lewis, and Fischer male and female rats. AN - 67689012; 16499484 AB - Hypothalamic synthesis and secretion of corticotropin-releasing hormone (CRH), a putative mediator of various behavioral and physiological responses to ethanol (EtOH), is defective in inbred Lewis (LEW) rats in comparison with their genetically related inbred Fischer 344 (F344) and outbred Sprague-Dawley (S-D) strains. We aimed to characterize the effects of continuous EtOH consumption and withdrawal on circadian patterns of body temperature and spontaneous locomotor activity in males and females of these 3 strains. Adult LEW, F344, and S-D males and randomly cycling females were fed an EtOH-containing liquid diet or the control (pair-fed or lab chow and water) diet for 14 days. Biotelemetric body temperature data for the last 3 days of EtOH diet feeding and the first 3 days of withdrawal were subjected to cosinor analysis of the circadian rhythm parameters of midline-estimating statistic of rhythm (MESOR), amplitude, and acrophase. Mean dark-phase activity during these periods was also computed. In the control diet condition, the MESORs and amplitudes of LEW males were lower than those of F344 males. MESORs of rhythms of LEW females were lower than those of both F344 and S-D females. Ethanol consumption caused hypothermia with reduced MESORs and amplitudes of LEW and F344 males and amplitudes of F344 and S-D females. Upon withdrawal, MESORs of the males increased during each day as the amplitudes decreased, reflective of their initial withdrawal-induced dark-phase hypothermia, which was most pronounced in the LEW males, followed by light-phase hyperthermia. MESORs of females were not affected by withdrawal; their amplitudes were differentially affected. Acrophase of LEW males shifted from dark to light on the first day of withdrawal. All rats responded to EtOH exposure with a reduction of dark-phase spontaneous locomotor activity and an immediate increase upon withdrawal. Body temperature rhythms of the males were generally more affected by EtOH consumption and withdrawal than the females; within each sex, LEW and F344 rats differed significantly. The specific hormonal factors that mediate the differential temperature responses remain to be defined. JF - Alcoholism, clinical and experimental research AU - Taylor, Anna N AU - Tio, Delia L AU - Bando, Jennifer K AU - Romeo, Horacio E AU - Prolo, Paolo AD - Veterans Administration Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, California, USA. ataylor@mednet.ucla.edu Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 438 EP - 447 VL - 30 IS - 3 SN - 0145-6008, 0145-6008 KW - Central Nervous System Depressants KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Rats, Inbred Lew KW - Rats, Inbred F344 KW - Sex Characteristics KW - Telemetry KW - Body Weight -- drug effects KW - Motor Activity -- drug effects KW - Species Specificity KW - Male KW - Female KW - Ethanol -- adverse effects KW - Central Nervous System Depressants -- pharmacology KW - Substance Withdrawal Syndrome -- physiopathology KW - Central Nervous System Depressants -- adverse effects KW - Body Temperature -- drug effects KW - Ethanol -- pharmacology KW - Circadian Rhythm -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67689012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Differential+effects+of+alcohol+consumption+and+withdrawal+on+circadian+temperature+and+activity+rhythms+in+Sprague-Dawley%2C+Lewis%2C+and+Fischer+male+and+female+rats.&rft.au=Taylor%2C+Anna+N%3BTio%2C+Delia+L%3BBando%2C+Jennifer+K%3BRomeo%2C+Horacio+E%3BProlo%2C+Paolo&rft.aulast=Taylor&rft.aufirst=Anna&rft.date=2006-03-01&rft.volume=30&rft.issue=3&rft.spage=438&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-12 N1 - Date created - 2006-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Brain metabolite concentrations and neurocognition during short-term recovery from alcohol dependence: Preliminary evidence of the effects of concurrent chronic cigarette smoking. AN - 67688390; 16499496 AB - Longitudinal studies of brain tissue metabolite recovery in short-term abstinent alcoholics have primarily investigated the frontal lobes and cerebellum with variable results. Preliminary proton magnetic resonance spectroscopic imaging (1H MRSI) suggested that chronic cigarette smoking exacerbates alcohol-induced brain injury in 1-week abstinent alcoholics. However, the potential effects of chronic cigarette smoking on the recovery of alcohol-induced brain injury have not been studied. Multislice short-echo time 1H MRSI was used to measure longitudinal changes in common brain metabolites in 25 recovering alcohol-dependent individuals (RA), retrospectively assigned to smoking (n = 14) and nonsmoking (n = 11) subgroups. Recovering alcohol-dependent individuals in longitudinal analyses were studied after approximately 7 and 34 days of abstinence from alcohol. In cross-sectional analyses, 36 RA (19 smokers, 17 nonsmokers) with approximately 34 days of sobriety were compared with 29 light drinkers (LD). Relationships between neurocognition and metabolite concentrations in abstinent RA were also examined. Over 1 month of abstinence from alcohol, RA, as a group, showed significant increases of regional N-acetylaspartate (NAA; marker of neuronal viability) and choline-containing compounds (Cho; marker of cell membrane synthesis/turnover) primarily in frontal and parietal lobes. These increases appeared to be driven by nonsmoking RA. Cross-sectional results indicate that metabolite levels in RA at 35 days of sobriety are not significantly different from those in LD in most regions, except for lower NAA and Cho in parietal WM and subcortical structures. However, metabolite levels at that time appear to be strongly modulated by smoking status. The patterns of metabolite-neurocognition relationships were different for nonsmoking and smoking RA. Within the first weeks of sobriety, regional brain NAA and Cho levels increased, but metabolite levels did not normalize in all brain regions after 35 days of sobriety. Neurobiologic recovery in RA appeared to be adversely affected by chronic smoking. Greater consideration of the effects of continued cigarette smoking on the neurobiologic and neurocognitive recovery of alcohol-dependent individuals is warranted. JF - Alcoholism, clinical and experimental research AU - Durazzo, Timothy C AU - Gazdzinski, Stefan AU - Rothlind, Johannes C AU - Banys, Peter AU - Meyerhoff, Dieter J AD - San Francisco Veterans Administration Medical Center, San Francisco, California 94121, USA. timothy.durazzo@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 539 EP - 551 VL - 30 IS - 3 SN - 0145-6008, 0145-6008 KW - Aspartic Acid KW - 30KYC7MIAI KW - N-acetylaspartate KW - 997-55-7 KW - Choline KW - N91BDP6H0X KW - Index Medicus KW - Magnetic Resonance Imaging KW - Aspartic Acid -- metabolism KW - Cerebral Cortex -- metabolism KW - Memory -- drug effects KW - Humans KW - Choline -- metabolism KW - Learning -- drug effects KW - Erythrocytes -- metabolism KW - Longitudinal Studies KW - Cross-Sectional Studies KW - Thalamus -- metabolism KW - Psychiatric Status Rating Scales KW - Aspartic Acid -- analogs & derivatives KW - Psychomotor Performance -- drug effects KW - Adult KW - Data Interpretation, Statistical KW - Middle Aged KW - Image Processing, Computer-Assisted KW - Male KW - Female KW - Intelligence Tests KW - Cognition -- drug effects KW - Brain Chemistry -- drug effects KW - Smoking -- metabolism KW - Alcoholism -- metabolism KW - Smoking -- psychology KW - Alcoholism -- psychology KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67688390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Brain+metabolite+concentrations+and+neurocognition+during+short-term+recovery+from+alcohol+dependence%3A+Preliminary+evidence+of+the+effects+of+concurrent+chronic+cigarette+smoking.&rft.au=Durazzo%2C+Timothy+C%3BGazdzinski%2C+Stefan%3BRothlind%2C+Johannes+C%3BBanys%2C+Peter%3BMeyerhoff%2C+Dieter+J&rft.aulast=Durazzo&rft.aufirst=Timothy&rft.date=2006-03-01&rft.volume=30&rft.issue=3&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-12 N1 - Date created - 2006-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cell phones for ecological momentary assessment with cocaine-addicted homeless patients in treatment. AN - 67682102; 16490673 AB - This is the first study to examine whether cell phones could be used to collect ecological momentary assessment (EMA) data with homeless crack cocaine-addicted adults in treatment. The study adapted an EMA method to examine behavior in real time using cell phones and computer-automated telephone interviewing. Participants treated in an intensive outpatient treatment program were given cell phones for a 2-week period to record current states of cocaine craving and using episodes. Results showed cell phone technology could reliably deliver a computerized survey; this homeless population would use a cell phone to report craving and using episodes, and drug use reported via EMA was in agreement with urine toxicology results for 73% of participants. Of 30 participants, 24 (80%) completed the full 2-week protocol. Participants indicated the survey made them more aware of phenomena leading to cravings and use, suggesting the usefulness of EMA as a potential intervention. JF - Journal of substance abuse treatment AU - Freedman, Michelle J AU - Lester, Kristin M AU - McNamara, Cecelia AU - Milby, Jesse B AU - Schumacher, Joseph E AD - Department of Psychology, University of Alabama at Birmingham, 35294, USA. michelle.freedman@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 105 EP - 111 VL - 30 IS - 2 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Disruptive, Impulse Control, and Conduct Disorders -- epidemiology KW - Community Mental Health Services -- supply & distribution KW - Humans KW - Adult KW - Time Factors KW - Male KW - Female KW - Ambulatory Care KW - Environment KW - Homeless Persons -- statistics & numerical data KW - Surveys and Questionnaires KW - Cocaine-Related Disorders -- epidemiology KW - Cell Phones KW - Cocaine-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67682102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Cell+phones+for+ecological+momentary+assessment+with+cocaine-addicted+homeless+patients+in+treatment.&rft.au=Freedman%2C+Michelle+J%3BLester%2C+Kristin+M%3BMcNamara%2C+Cecelia%3BMilby%2C+Jesse+B%3BSchumacher%2C+Joseph+E&rft.aulast=Freedman&rft.aufirst=Michelle&rft.date=2006-03-01&rft.volume=30&rft.issue=2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2006-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of rosiglitazone on lipids, adipokines, and inflammatory markers in nondiabetic patients with low high-density lipoprotein cholesterol and metabolic syndrome. AN - 67664200; 16357312 AB - PPAR-gamma agonists improve insulin sensitivity and glycemic control in type 2 diabetes and may reduce atherosclerosis progression. Thus, PPAR-gamma agonists may be an effective therapy for metabolic syndrome. However, the full spectrum of potentially antiatherogenic mechanisms of PPAR-gamma agonists have not been fully tested in nondiabetic patients with metabolic syndrome. We performed a prospective, double-blinded, placebo-controlled study of 60 nondiabetic subjects with low high-density lipoprotein cholesterol (HDL-C) level and metabolic syndrome to rosiglitazone 8 mg daily or placebo for 12 weeks. We found no significant effect of rosiglitazone on HDL-C (+5.5% versus +5.8%, P=0.89), and an increase in total cholesterol (+8% versus -1%; P=0.03). Nevertheless, rosiglitazone significantly increased adiponectin (+168% versus +25%; P<0.001), and lowered resistin (-6% versus +4%; P=0.009), C-reactive protein (-32% versus +36%, P=0.002), interleukin (IL)-6 (-22% versus +4%, P<0.001), and soluble tumor-necrosis factor-alpha receptor-2 (-5% versus +7%, P<0.001). These findings suggest that rosiglitazone, presumably through its PPAR-gamma agonist properties, has direct effects on inflammatory markers and adipokines in the absence of favorable lipid effects. These findings may help explain the mechanism underlying the possible antiatherosclerotic effects of rosiglitazone. JF - Arteriosclerosis, thrombosis, and vascular biology AU - Samaha, Frederick F AU - Szapary, Philippe O AU - Iqbal, Nayyar AU - Williams, Monica M AU - Bloedon, LeAnne T AU - Kochar, Arshneel AU - Wolfe, Megan L AU - Rader, Daniel J AD - Cardiovascular Division, Department of Medicine, Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA, USA. rick.samaha@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 624 EP - 630 VL - 26 IS - 3 KW - Adiponectin KW - 0 KW - Apolipoproteins B KW - Biomarkers KW - Cholesterol, HDL KW - Fatty Acids, Nonesterified KW - Hypoglycemic Agents KW - Interleukin-6 KW - PPAR gamma KW - RETN protein, human KW - Receptors, Tumor Necrosis Factor, Type II KW - Resistin KW - Thiazolidinediones KW - rosiglitazone KW - 05V02F2KDG KW - C-Reactive Protein KW - 9007-41-4 KW - Index Medicus KW - Humans KW - Resistin -- blood KW - Aged KW - Receptors, Tumor Necrosis Factor, Type II -- blood KW - Interleukin-6 -- blood KW - Adult KW - Body Weight -- drug effects KW - Middle Aged KW - Insulin Resistance KW - Blood Pressure -- drug effects KW - Adolescent KW - Apolipoproteins B -- blood KW - Fatty Acids, Nonesterified -- blood KW - Biomarkers -- blood KW - Male KW - Adiponectin -- blood KW - C-Reactive Protein -- metabolism KW - Female KW - PPAR gamma -- agonists KW - Cholesterol, HDL -- blood KW - Hypoglycemic Agents -- administration & dosage KW - Thiazolidinediones -- adverse effects KW - Hypoglycemic Agents -- adverse effects KW - Metabolic Syndrome X -- immunology KW - Metabolic Syndrome X -- blood KW - Metabolic Syndrome X -- drug therapy KW - Thiazolidinediones -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67664200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.atitle=Effects+of+rosiglitazone+on+lipids%2C+adipokines%2C+and+inflammatory+markers+in+nondiabetic+patients+with+low+high-density+lipoprotein+cholesterol+and+metabolic+syndrome.&rft.au=Samaha%2C+Frederick+F%3BSzapary%2C+Philippe+O%3BIqbal%2C+Nayyar%3BWilliams%2C+Monica+M%3BBloedon%2C+LeAnne+T%3BKochar%2C+Arshneel%3BWolfe%2C+Megan+L%3BRader%2C+Daniel+J&rft.aulast=Samaha&rft.aufirst=Frederick&rft.date=2006-03-01&rft.volume=26&rft.issue=3&rft.spage=624&rft.isbn=&rft.btitle=&rft.title=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.issn=1524-4636&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-24 N1 - Date created - 2006-02-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1413-4 [16709957] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mantram repetition for stress management in veterans and employees: a critical incident study AN - 57106590; 200705821 AB - Aim. This paper reports a study assessing the usefulness of a mantram repetition programme. Background. Complementary/alternative therapies are becoming commonplace, but more research is needed to assess their benefits. A 5-week programme teaching a 'mind-body-spiritual' technique of silently repeating a mantram - a word or phrase with spiritual meaning - to manage stress was developed. A mantram was chosen by individuals, who were taught to repeat it silently throughout the day or night to interrupt unwanted thoughts and elicit the relaxation response. Methods. Participants who attended a 5-week course were invited to participate in the study. Of those who consented, a randomly selected subset (n = 66) was contacted approximately 3 months after the course for a telephone interview using the critical incident interviewing technique. Participants were asked whether the intervention was helpful or not, and if helpful, to identify situations where it was applied. Interviews were transcribed and incidents were identified and categorized to create a taxonomy of uses. The data were collected in 2001-2002. Results. Participants included 30 veterans, mostly males (97%), and 36 hospital employees, mostly females (86%). Mean age was 56 years (sd = 12.94). Fifty-five participants (83.3%) practiced the technique and reported 147 incidents where the programme was helpful. Outcomes were organized into a taxonomy of incidents using four major categories that included managing: (a) emotions other than stress (51%); (b) stress (23.8%); (c) insomnia (12.9%); and (d) unwanted thoughts (12.3%). A group of raters reviewed the categories for inter-rater reliability. Conclusions. The majority of participants from two distinct samples reported that the mantram programme was helpful in a variety of situations. The critical incident interviewing method was found to be practical, efficient, and thorough in collecting and analyzing data. Such qualitative methods contribute to understanding the benefits of mind-body complementary therapies. Tables, Figures, y. Adapted from the source document. JF - Journal of Advanced Nursing AU - Bormann, Jill E AU - Oman, Doug AU - Kemppainen, Jeanne K AU - Becker, Sheryl AU - Gershwin, Madeline AU - Kelly, Ann AD - Nursing & Patient Care Services, VA San Diego Healthcare System, CA jill.bormann@va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 502 EP - 512 PB - Blackwell Publishing, Oxford UK VL - 53 IS - 5 SN - 0309-2402, 0309-2402 KW - alternative/complementary therapy KW - critical incident technique KW - mantram repetition KW - nursing KW - spirituality KW - stress management KW - Veterans KW - Relaxation training KW - Mind and body KW - Nurses KW - Stress management KW - Alternative medicine KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57106590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Advanced+Nursing&rft.atitle=Mantram+repetition+for+stress+management+in+veterans+and+employees%3A+a+critical+incident+study&rft.au=Bormann%2C+Jill+E%3BOman%2C+Doug%3BKemppainen%2C+Jeanne+K%3BBecker%2C+Sheryl%3BGershwin%2C+Madeline%3BKelly%2C+Ann&rft.aulast=Bormann&rft.aufirst=Jill&rft.date=2006-03-01&rft.volume=966&rft.issue=&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-05-30 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nurses; Veterans; Alternative medicine; Mind and body; Relaxation training; Stress management DO - http://dx.doi.org/10.1111/j.1365-2648.2006.03752.x ER - TY - JOUR T1 - Obesity Is a Risk Factor for Reporting Homebound Status among Community-Dwelling Older Persons AN - 20719741; 6814666 AB - OBJECTIVE: To test the a priori hypothesis that obesity is a predictor of risk for reporting homebound status. RESEARCH METHODS AND PROCEDURES: A longitudinal cohort study was conducted with 21,645 community-dwelling men and women 65 to 97 years old. A nutrition risk screen was administered baseline between 1994 and 1999 and again 3 to 4 years later. Univariate analyses identified baseline variables associated with subsequent reporting of homebound status. Multivariable logistic regression models were created to identify baseline variables that were significant independent predictors of reporting homebound status. RESULTS: At baseline, 24% of the cohort had BMI greater than or equal to 30. There were 12,834 (45% men) respondents at follow-up (68% response). Non-responders at follow-up differed little from responders except for greater baseline age (72.2 plus or minus 6.2 vs. 71.4 plus or minus 5.6 years, p < 0.001) and reporting of any functional limitations (9.2% vs. 4.9%, p < 0.001). At follow-up, those who reported homebound status (n = 169) were significantly (p < 0.001) older (80.3 plus or minus 7.3 vs. 75.1 plus or minus 5.5 years) and more likely to report functional limitations (83.4% vs. 10.8%). Univariate analyses identified 16 baseline variables that were eliminated stepwise until five significant independent predictors remained: age greater than or equal to 75 years (2.21, 1.55 to 3.15/odds ratio, 95% confidence interval), BMI greater than or equal to 35 (1.75, 1.04 to 2.96), poor appetite (2.50, 1.29 to 4.86), low income (1.59, 1.00 to 2.56), and any functional limitation (10.67, 7.36 to 15.46). DISCUSSION: Obesity remained a significant independent predictor for reporting homebound status and should be considered in screening of older populations and in the planning, implementation, and evaluation of services for homebound older persons. JF - Obesity Research AU - Jensen, Gordon L AU - Silver, Heidi J AU - Roy, Marie-Andree AU - Callahan, Eve AU - Still, Christopher AU - Dupont, William AD - Vanderbilt Center for Human Nutrition, Clinical Nutrition Research Unit, Veterans Administration Tennessee Valley Geriatric Research Education and Clinical Centers, and. Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee. Geisinger Medical Center, Danville, Pennsylvania Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 509 EP - 517 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 14 IS - 3 SN - 1071-7323, 1071-7323 KW - Physical Education Index; Risk Abstracts KW - Obesity KW - Age KW - research methods KW - Men KW - Women KW - obesity KW - Gerontology KW - Nutrition KW - Evaluation KW - income KW - Analysis KW - Risk factors KW - Planning KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20719741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Obesity+Is+a+Risk+Factor+for+Reporting+Homebound+Status+among+Community-Dwelling+Older+Persons&rft.au=Jensen%2C+Gordon+L%3BSilver%2C+Heidi+J%3BRoy%2C+Marie-Andree%3BCallahan%2C+Eve%3BStill%2C+Christopher%3BDupont%2C+William&rft.aulast=Jensen&rft.aufirst=Gordon&rft.date=2006-03-01&rft.volume=14&rft.issue=3&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Evaluation; Obesity; Men; Risk factors; Analysis; Planning; Women; Gerontology; Nutrition; Age; research methods; income; obesity ER - TY - JOUR T1 - Duration of Colonization with Methicillin-Resistant Staphylococcus aureus Among Patients in the Intensive Care Unit: Implications for Intervention AN - 19649587; 7399758 AB - OBJECTIVES. To determine the duration of methicillin-resistant Staphylococcus aureus (MRSA) colonization or infection before entry and during hospitalization in the intensive care unit (ICU) and the characteristics of patients who tested positive for MRSA. DESIGN. Prospective observational cohort survey. SETTING. A combined medical and coronary care ICU with 16 single-bed rooms in a 427-bed tertiary care Veteran Affairs Medical Center, PATIENTS. A total of 720 ICU patients associated with 845 ICU admissions were followed up for the detection of MRSA from January 13, 2003, to October 12, 2003. MRSA colonization was detected in patients by using active surveillance cultures (ASCs) of nasal swab specimens obtained within 48 hours of ICU entry and 3 times weekly thereafter. The duration of colonization during ICU stay and before ICU entry was calculated after a review of surveillance culture results, clinical culture results, and medical history. RESULTS. Ninety-three (11.0%) of 845 ICU admissions involved patients who were colonized with MRSA at the time of ICU entry, and 21 admissions (2.5%) involved patients who acquired MRSA during ICU stay. ASCs were positive for MRSA in 84 (73.6%) of the 114 admissions associated with MRSA positivity and were the sole means of identifying MRSA in 50 cases (43.8%). More than half of the MRSA-associated admissions involved patients who were transferred from hospital wards. The total bed-days of care for 38 admissions involving patients who tested positive for MRSA before ICU entry (1131 days) was nearly 20% higher than the total bed-days of care for all admissions associated with MRSA positivity (970 days). Admissions involving MRSA-positive patients were associated with a longer length of hospitalization before ICU entry (P< .001), longer length of ICU stay(P< .001), longer overall length of hospitalization(P< .001), and greater inpatient mortality than admissions involving MRSA-negative patients (P< .001). A total of 22.8% of all bed-care days were dedicated to MRSA-positive patients in the ICU, and 55 (48.2%) of 114 admissions associated with MRSA positivity involved patients who were colonized for the duration of their ICU stay. CONCLUSIONS. In our unit, ASCs were an effective means to identify MRSA colonization among patients admitted to the ICU. Unfortunately, the majority of identified patients had long durations of stay in our own hospital before ICU entry, with prolonged MRSA colonization. Enhanced efforts to control MRSA will have to account for the prevalence of MRSA within hospital wards and to direct control efforts at these patients in the future. JF - Infection Control and Hospital Epidemiology AU - Ridenour, G A AU - Wong, E S AU - Call, MA AU - Climo, M W AD - McGuire VAMC, 1201 Broad Rock Boulevard, Section 111-C, Richmond, VA 23249, USA, michael.climo@med.va.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 271 EP - 278 VL - 27 IS - 3 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology KW - Colonization KW - Mortality KW - Intensive care units KW - Drug resistance KW - Staphylococcus aureus KW - Infection KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19649587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Duration+of+Colonization+with+Methicillin-Resistant+Staphylococcus+aureus+Among+Patients+in+the+Intensive+Care+Unit%3A+Implications+for+Intervention&rft.au=Ridenour%2C+G+A%3BWong%2C+E+S%3BCall%2C+MA%3BClimo%2C+M+W&rft.aulast=Ridenour&rft.aufirst=G&rft.date=2006-03-01&rft.volume=27&rft.issue=3&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mortality; Colonization; Intensive care units; Drug resistance; Infection; Hospitals; Staphylococcus aureus ER - TY - JOUR T1 - Television Viewing Practices and Obesity Among Women Veterans AN - 19442954; 6772345 AB - BACKGROUND: Obesity is epidemic in the U.S. and has been associated with television viewing. OBJECTIVE: To describe the association between obesity and television viewing practices among women veterans. DESIGN, SETTING AND PARTICIPANTS: Cross-sectional, mailed survey completed by 1,555 female veterans enrolled at the VA Puget Sound Health Care System in 2000. MEASUREMENTS AND METHODS: We used bivariate and multivariate analyses to assess the association of obesity (body mass index >30 kg-m super(2) based on self-reported height and weight) with self-reported number of hours of television or videos viewed per day, and frequency of eating meals or snacking while watching television, controlling for other covariates. RESULTS: Watching television >2 hours per typical day on week days and-or weekends was associated with obesity (P2 hours per day and eating or snacking while watching television were each associated with obesity (odds ratio [OR] 1.4, 95% confidence interval [CI] 1.1 to 1.8; and OR 1.3, 95% CI 1.0 to 1.7, respectively), after adjusting for demographic variables, smoking, physical activity, and depression. Results were similar when posttraumatic stress disorder was included in the model instead of depression. Women who both watched >2 hours of television per day and ate or snacked while viewing were almost twice as likely to be obese (OR 1.9, 95% CI 1.4 to 2.6). CONCLUSION: Watching television over 2 hours per day and eating while watching television were each associated with obesity among female VA patients and may be modifiable risk factors for obesity. JF - Journal of General Internal Medicine AU - Johnson, Kay M AU - Nelson, Karin M AU - Bradley, Katharine A AD - Dr. Johnson: VA Puget Sound Health Care System, Mailstop S-111-GIMC, 1660 S. Columbian Way, Seattle, WA, 98108, Kay.Johnson2@med.va.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - S76 EP - S81 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 21 IS - S3 SN - 0884-8734, 0884-8734 KW - Physical Education Index KW - Obesity KW - Measurement KW - Videotape KW - Depression KW - Eating disorders KW - Body mass KW - Women KW - Diet (weight control) KW - Height KW - Stress KW - Surveys KW - Health KW - Patients KW - Exercise KW - Demographics KW - Smoking KW - Analysis KW - Risk factors KW - Television KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19442954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+General+Internal+Medicine&rft.atitle=Television+Viewing+Practices+and+Obesity+Among+Women+Veterans&rft.au=Johnson%2C+Kay+M%3BNelson%2C+Karin+M%3BBradley%2C+Katharine+A&rft.aulast=Johnson&rft.aufirst=Kay&rft.date=2006-03-01&rft.volume=21&rft.issue=S3&rft.spage=S76&rft.isbn=&rft.btitle=&rft.title=Journal+of+General+Internal+Medicine&rft.issn=08848734&rft_id=info:doi/10.1111%2Fj.1525-1497.2006.00379.x LA - English DB - Physical Education Index N1 - Date revised - 2007-06-01 N1 - SuppNotes - Tables, 4; references, 37. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Measurement; Obesity; Videotape; Depression; Eating disorders; Body mass; Women; Diet (weight control); Surveys; Stress; Height; Patients; Health; Exercise; Demographics; Smoking; Risk factors; Analysis; Television DO - http://dx.doi.org/10.1111/j.1525-1497.2006.00379.x ER - TY - JOUR T1 - Antipsychotic-associated neuronal changes in the brain: Toxic, therapeutic, or irrelevant to the long-term outcome of schizophrenia? AN - 17078218; 6692814 AB - The increasingly wide-spread use of antipsychotics in both adults and children calls for a detailed examination of antipsychotic-associated neuronal changes in the brain, and whether these changes are toxic, therapeutic, or perhaps irrelevant to the outcome of major psychiatric disorders, especially schizophrenia. In this review we will examine the extensive evidence demonstrating both acute and longer-term antipsychotic-associated neurotoxicity and neuroplasticity, as well as the more specific cellular changes that appear to underlie these phenomena. These include changes in proteins affecting cell survival, impairment of the mitochondrial respiratory chain, increases in DNA fragmentation, injury to dendritic microtubules, increases in dopamine-generated reactive oxygen species, changes in cell morphology, and rapid induction of apoptosis. We shall also examine the correlation between these changes and alterations in gross brain structure. There appears to be a disjunction between the widespread cellular and gross structural brain changes in schizophrenia, and the duration of illness, expression of symptoms, and response to treatment. We shall explore possible explanations for this apparent paradox. JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry AU - Dean, Charles E AD - Tardive Dyskinesia Assessment Clinic, Minneapolis VA Medical Center, One Veterans Drive, Minneapolis Minnesota 55417, USA, charles.dean@med.va.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 174 EP - 189 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 30 IS - 2 SN - 0278-5846, 0278-5846 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Antipsychotics KW - Atypical antipsychotics KW - Neuroplasticity KW - Neurotoxicity KW - Schizophrenia KW - Structural brain changes KW - Cell survival KW - Microtubules KW - Apoptosis KW - Injuries KW - Brain KW - Mitochondria KW - Children KW - Disjunction KW - DNA fragmentation KW - Mental disorders KW - Reactive oxygen species KW - Reviews KW - Neuroleptics KW - Cytology KW - Plasticity (dendritic) KW - Electron transport KW - X 24310:Pharmaceuticals KW - N3 11047:Neuropsychobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17078218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+Neuro-Psychopharmacology+and+Biological+Psychiatry&rft.atitle=Antipsychotic-associated+neuronal+changes+in+the+brain%3A+Toxic%2C+therapeutic%2C+or+irrelevant+to+the+long-term+outcome+of+schizophrenia%3F&rft.au=Dean%2C+Charles+E&rft.aulast=Dean&rft.aufirst=Charles&rft.date=2006-03-01&rft.volume=30&rft.issue=2&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Progress+in+Neuro-Psychopharmacology+and+Biological+Psychiatry&rft.issn=02785846&rft_id=info:doi/10.1016%2Fj.pnpbp.2005.08.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Microtubules; Apoptosis; Injuries; Brain; Mitochondria; Children; Disjunction; Schizophrenia; DNA fragmentation; Mental disorders; Reactive oxygen species; Neuroleptics; Reviews; Neurotoxicity; Cytology; Plasticity (dendritic); Electron transport DO - http://dx.doi.org/10.1016/j.pnpbp.2005.08.019 ER - TY - JOUR T1 - Brief communication: Better ways to question patients about adverse medical events: a randomized, controlled trial. AN - 67675703; 16490911 AB - There is no standard method of identifying adverse events in clinical trials. To determine whether 3 different methods of questioning patients about adverse events in a clinical trial affect the frequency of reported events. Randomized, single-blind, controlled trial. A Veterans Administration medical center, San Francisco, California. Men 50 years of age or older who had benign prostatic hyperplasia. Frequency of self-reported medical problems. The authors randomly assigned 214 men who were undergoing a 1-month, single-blind, placebo run-in period during an existing clinical trial to 3 groups to test different self-administered methods of assessing medical problems at the end of the run-in period. The first group was asked an open-ended question; the second group was asked an open-ended, defined question; and the third group was given a checklist of 53 common side effects. All 214 patients completed the study. Patients assigned to the checklist group reported a total of 238 adverse events; in comparison, patients who were asked an open-ended question or an open-ended, defined question reported 11 and 14 adverse events, respectively (P < 0.001). The percentage of patients reporting any adverse event was also much higher in the group assigned to the checklist (77%) than in the first group (14%) or second group (13%) (P < 0.001). The study included only relatively healthy, well-educated, middle-aged men and assessed only self-reported medical problems after the participants had taken placebo for 1 month. All personnel overseeing the study were aware of the group assignments. Different methods of collecting patient data regarding adverse events lead to large differences in the reported rates of adverse events in clinical trials, potentially reducing the validity of comparisons between the side effect profiles of drugs and other interventions. JF - Annals of internal medicine AU - Bent, Stephen AU - Padula, Amy AU - Avins, Andrew L AD - University of California and San Francisco Veterans Administration Medical Center, San Francisco, California 94121, USA. bent@itsa.ucsf.edu Y1 - 2006/02/21/ PY - 2006 DA - 2006 Feb 21 SP - 257 EP - 261 VL - 144 IS - 4 KW - Abridged Index Medicus KW - Index Medicus KW - Single-Blind Method KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Surveys and Questionnaires -- standards KW - Drug-Related Side Effects and Adverse Reactions KW - Randomized Controlled Trials as Topic -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67675703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Brief+communication%3A+Better+ways+to+question+patients+about+adverse+medical+events%3A+a+randomized%2C+controlled+trial.&rft.au=Bent%2C+Stephen%3BPadula%2C+Amy%3BAvins%2C+Andrew+L&rft.aulast=Bent&rft.aufirst=Stephen&rft.date=2006-02-21&rft.volume=144&rft.issue=4&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-14 N1 - Date created - 2006-02-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Intern Med. 2006 Feb 21;144(4):298-300 [16490917] Erratum In: Ann Intern Med. 2006 Jul 18;145(2):156 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transposome mutagenesis of an integral membrane transporter in Corynebacterium matruchotii AN - 17077591; 6710511 AB - A transposon-5 insertion library of Corynebacterium matruchotii ATCC14266 was generated and screened for mutants with altered corynomycolic acid content. One of these designated 319 mutants showed an interruption of a gene encoding an integral membrane protein. MALDI mass spectra of trehalose monocorynomycolate (TMCM), trehalose dicorynomycolate, and methyl corynomycolates derived from cell wall arabinogalactan-corynomycolate showed that these lipids from the mutant contained a lower amount of short-chain (C sub(2) sub(4) to C sub(3) sub(4)) and much greater amount of long-chain (primarily C sub(3) sub(6) sub(:) sub(2)) corynomycolic acids than the wild type. An analysis of mRNA demonstrated that the integral membrane protein and ATP-binding cassette transporter are transcriptionally coupled. These results suggested that the proteins/enzymes encoded by the membrane transporter gene locus preferably move short-chain corynomycolic acids from the cytoplasm across the membrane bilayer to the periplasmic space where the synthesis of TMCM is thought to occur. This is the first evidence linking corynomycolic acid to a transporter gene locus. JF - Biochemical and Biophysical Research Communications AU - Wang, C AU - Hayes, B AU - Vestling, M M AU - Takayama, K AD - William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA, Kuni.Takayama@med.va.gov Y1 - 2006/02/17/ PY - 2006 DA - 2006 Feb 17 SP - 953 EP - 960 VL - 340 IS - 3 SN - 0006-291X, 0006-291X KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Periplasmic space KW - Lipids KW - ATP-binding protein KW - Cytoplasm KW - Transcription KW - Enzymes KW - Corynebacterium matruchotii KW - Trehalose KW - Membrane proteins KW - Cell walls KW - Mutagenesis KW - N 14810:Methods KW - G 07770:Bacteria KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17077591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Transposome+mutagenesis+of+an+integral+membrane+transporter+in+Corynebacterium+matruchotii&rft.au=Wang%2C+C%3BHayes%2C+B%3BVestling%2C+M+M%3BTakayama%2C+K&rft.aulast=Wang&rft.aufirst=C&rft.date=2006-02-17&rft.volume=340&rft.issue=3&rft.spage=953&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2005.12.097 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Periplasmic space; Cytoplasm; ATP-binding protein; Lipids; Enzymes; Transcription; Membrane proteins; Trehalose; Mutagenesis; Cell walls; Corynebacterium matruchotii DO - http://dx.doi.org/10.1016/j.bbrc.2005.12.097 ER - TY - CPAPER T1 - Success Under Pressure: Strategies to Reduce Musculoskeletal Injuries in the Hospital Setting T2 - 10th Annual Meeting of the Biofeedback Foundation of Europe AN - 39933566; 4158792 JF - 10th Annual Meeting of the Biofeedback Foundation of Europe AU - Frobish, Candy AU - Peper, Erik Y1 - 2006/02/14/ PY - 2006 DA - 2006 Feb 14 KW - Musculoskeletal system KW - Hospitals KW - Injuries KW - Pressure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39933566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Annual+Meeting+of+the+Biofeedback+Foundation+of+Europe&rft.atitle=Success+Under+Pressure%3A+Strategies+to+Reduce+Musculoskeletal+Injuries+in+the+Hospital+Setting&rft.au=Frobish%2C+Candy%3BPeper%2C+Erik&rft.aulast=Frobish&rft.aufirst=Candy&rft.date=2006-02-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Annual+Meeting+of+the+Biofeedback+Foundation+of+Europe&rft.issn=&rft_id=info:doi/ L2 - http://www.bfe.org/meeting/SCIENTIFIC%20PROGRAM%20ON%20WEB.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dlk1 and MNDA Protein Expression in Myeloid Progenitors: Utility of Dlk1 as an Immunohistochemical Marker of the Megakaryocytic Lineage T2 - 95th Annual Meeting of the United States and Canadian Academy of Pathology AN - 39826522; 4102365 JF - 95th Annual Meeting of the United States and Canadian Academy of Pathology AU - McClintock-Treep, S A AU - Jagasia, M H AU - Goodman, S A AU - Briggs, R C AU - Head, D R Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Stem cells KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39826522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Dlk1+and+MNDA+Protein+Expression+in+Myeloid+Progenitors%3A+Utility+of+Dlk1+as+an+Immunohistochemical+Marker+of+the+Megakaryocytic+Lineage&rft.au=McClintock-Treep%2C+S+A%3BJagasia%2C+M+H%3BGoodman%2C+S+A%3BBriggs%2C+R+C%3BHead%2C+D+R&rft.aulast=McClintock-Treep&rft.aufirst=S&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.uscap.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Outcomes of clinical trial: tinnitus masking versus tinnitus retraining therapy. AN - 85388740; pmid-16640064 AB - A controlled clinical study was conducted to evaluate prospectively the clinical efficacy of tinnitus masking (TM) and tinnitus retraining therapy (TRT) in military veterans having clinically significant tinnitus. Qualifying patients were placed into the two groups in an alternating manner (to avoid selection bias), and treatment was administered at 0, 3, 6, 12, and 18 months. Outcomes of treatment were evaluated using three self-administered tinnitus questionnaires (Tinnitus Handicap Inventory, Tinnitus Handicap Questionnaire, Tinnitus Severity Index) and the verbally administered TRT interview forms. Findings are presented from the three written questionnaires, and from two of the interview questions (percentage time aware of, and annoyed by, tinnitus). Outcomes were analyzed on an intent-to-treat basis, using a multilevel modeling approach. Of the 123 patients enrolled, 118 were included in the analysis. Both groups showed significant declines (improvements) on these measures, with the TRT decline being significantly greater than for TM. The greater declines in TRT compared to TM occurred most strongly in patients who began treatment with a "very big" tinnitus problem. When patients began treatment with a "moderate" tinnitus problem, the benefits of TRT compared to TM were more modest. JF - Journal of the American Academy of Audiology AU - Henry, James A AU - Schechter, Martin A AU - Zaugg, Tara L AU - Griest, Susan AU - Jastreboff, Pawel J AU - Vernon, Jack A AU - Kaelin, Christine AU - Meikle, Mary B AU - Lyons, Karen S AU - Stewart, Barbara J AD - VA RR&D National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Oregon, USA. james.henry@med.va.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 104 EP - 132 VL - 17 IS - 2 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - *Acoustic Stimulation KW - Analysis of Variance KW - Female KW - Follow-Up Studies KW - Humans KW - Male KW - Middle Aged KW - *Perceptual Masking KW - Predictive Value of Tests KW - Prospective Studies KW - Questionnaires KW - *Tinnitus: therapy KW - Treatment Outcome KW - Veterans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85388740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Outcomes+of+clinical+trial%3A+tinnitus+masking+versus+tinnitus+retraining+therapy.&rft.au=Henry%2C+James+A%3BSchechter%2C+Martin+A%3BZaugg%2C+Tara+L%3BGriest%2C+Susan%3BJastreboff%2C+Pawel+J%3BVernon%2C+Jack+A%3BKaelin%2C+Christine%3BMeikle%2C+Mary+B%3BLyons%2C+Karen+S%3BStewart%2C+Barbara+J&rft.aulast=Henry&rft.aufirst=James&rft.date=2006-02-01&rft.volume=17&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Effects of oxandrolone, an anabolic steroid, on hemostasis. AN - 70715366; 16432848 AB - This study evaluated the short-term effects of oxandrolone, an anabolic androgenic synthetic steroid, on blood coagulation and the hemostatic/fibrinolytic system in healthy individuals. Subjects (n = 14) were administered oxandrolone (10 mg twice daily) for 14 days. Blood was obtained on days 0, 1, 3, 7, 9, 14, and then at day 42 (28 days after discontinuation of the drug). Samples were analyzed for the plasma plasminogen, plasminogen activator inhibitor (PAI-1), fibrinogen, and coagulation factors (II, V, VII, VIII, and X). After 7 days of administration of oxandrolone, the plasma plasminogen level significantly increased [100% +/- 21% to 174% +/- 21% (P < 0.0001)]. PAI-1 was significantly decreased at day 3 [16 +/- 9 to 7 +/- 4 mg/dL (P < 0.01)]. Coagulation factors II and V significantly increased at day 14 [88 +/- 15 to 122 +/- 11 (P < 0.005) and 105 +/- 21 to 179 +/- 36% (P < 0.0001)], respectively. Factor VII level decreased by day 3 [91% +/- 26% to 83% +/- 18%, NS], but after 14 days factor VII level returned to baseline (91% +/- 26% to 93% +/- 19%, NS). The increase of factor VIII level was not significant (111% +/- 64% to 125% +/- 55%, NS). Factor X increased steadily over 14 days of drug treatment [96% +/- 11% to 107% +/- 25%, NS] and after discontinuation, decreased and returned to baseline by day 42 [107% +/- 25% to 89% +/- 25%, NS]. Fibrinogen decreased by 22% +/- 12%, (NS). Administration of oxandrolone, to healthy young men was associated with a significant increase in select blood coagulation factors and plasminogen. These changes create a state of potential hypercoagulability that appears to be counterbalanced by increased fibrinolytic activity to maintain homeostasis. 2006 Wiley-Liss, Inc. JF - American journal of hematology AU - Kahn, Nighat N AU - Sinha, Asru K AU - Spungen, Ann M AU - Bauman, William A AD - Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA. nighat.kahn@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 95 EP - 100 VL - 81 IS - 2 SN - 0361-8609, 0361-8609 KW - Anabolic Agents KW - 0 KW - Biomarkers KW - Blood Coagulation Factors KW - Plasminogen Activator Inhibitor 1 KW - SERPINE1 protein, human KW - Steroids KW - Oxandrolone KW - 7H6TM3CT4L KW - Plasminogen KW - 9001-91-6 KW - Index Medicus KW - Humans KW - Adult KW - Plasminogen Activator Inhibitor 1 -- blood KW - Fibrinolysis -- drug effects KW - Steroids -- pharmacology KW - Steroids -- administration & dosage KW - Middle Aged KW - Blood Coagulation Factors -- analysis KW - Thrombophilia -- chemically induced KW - Plasminogen -- analysis KW - Biomarkers -- blood KW - Male KW - Anabolic Agents -- pharmacology KW - Oxandrolone -- administration & dosage KW - Hemostasis -- drug effects KW - Oxandrolone -- pharmacology KW - Anabolic Agents -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70715366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hematology&rft.atitle=Effects+of+oxandrolone%2C+an+anabolic+steroid%2C+on+hemostasis.&rft.au=Kahn%2C+Nighat+N%3BSinha%2C+Asru+K%3BSpungen%2C+Ann+M%3BBauman%2C+William+A&rft.aulast=Kahn&rft.aufirst=Nighat&rft.date=2006-02-01&rft.volume=81&rft.issue=2&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hematology&rft.issn=03618609&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-14 N1 - Date created - 2006-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The efficacy of olanzapine for decreasing cue-elicited craving in individuals with schizophrenia and cocaine dependence: a preliminary report. AN - 70695304; 16415698 AB - Although a growing body of research suggests that atypical neuroleptic medications are efficacious in the treatment of cocaine addiction among individuals with schizophrenia, more rigorously controlled trials are needed. To extend this research, we performed a 6-week double-blind study comparing olanzapine to haloperidol with the primary objective of reducing cue-elicited cocaine craving and the secondary aims of decreasing substance use, improving psychiatric symptoms, and determining an effect size for future studies. Thirty-one subjects with cocaine dependence and schizophrenia were randomized to olanzapine or haloperidol, underwent a cue-exposure procedure, and completed psychiatric and substance abuse ratings. Individuals in the olanzapine group who completed the study had a significant reduction on the energy subscale of the Voris Cocaine Craving Scale at study completion compared with individuals in the haloperidol group. The olanzapine-treated group also had lower, but not statistically significant, PANSS General Psychopathology Subscale scores and fewer positive urine toxicology screens compared with those in the haloperidol group. This small, but rigorously controlled, pilot trial provides additional evidence for the use of atypical antipsychotics for the treatment of individuals with co-occurring schizophrenia and cocaine dependence. Reductions in craving were associated with medium to large effect sizes. JF - Journal of clinical psychopharmacology AU - Smelson, David A AU - Ziedonis, Douglas AU - Williams, John AU - Losonczy, Miklos F AU - Williams, Jill AU - Steinberg, Marc L AU - Kaune, Maureen AD - Department of Veterans Affairs, New Jersey Health Care System, Lyons, NJ 07939-5000, USA. David.Smelson@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 9 EP - 12 VL - 26 IS - 1 SN - 0271-0749, 0271-0749 KW - Antipsychotic Agents KW - 0 KW - Benzodiazepines KW - 12794-10-4 KW - Haloperidol KW - J6292F8L3D KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - Haloperidol -- therapeutic use KW - Benzodiazepines -- therapeutic use KW - Psychiatric Status Rating Scales KW - Double-Blind Method KW - Humans KW - Adult KW - Cues KW - Pilot Projects KW - Behavior, Addictive -- drug therapy KW - Antipsychotic Agents -- therapeutic use KW - Cocaine-Related Disorders -- drug therapy KW - Schizophrenia -- drug therapy KW - Schizophrenia -- complications KW - Cocaine-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70695304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=The+efficacy+of+olanzapine+for+decreasing+cue-elicited+craving+in+individuals+with+schizophrenia+and+cocaine+dependence%3A+a+preliminary+report.&rft.au=Smelson%2C+David+A%3BZiedonis%2C+Douglas%3BWilliams%2C+John%3BLosonczy%2C+Miklos+F%3BWilliams%2C+Jill%3BSteinberg%2C+Marc+L%3BKaune%2C+Maureen&rft.aulast=Smelson&rft.aufirst=David&rft.date=2006-02-01&rft.volume=26&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-03 N1 - Date created - 2006-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oxymorphone: a review. AN - 70689841; 16317569 AB - Oxymorphone (oxymorphone hydrochloride) (14-hydroxy-dihydromorphinone), a semisynthetic mu-opioid agonist, was first approved by the US Food and Drug Administration in 1959. Oxymorphone is considered a more potent opioid than its parent compound, morphine. Recently, an immediate-release and long-acting oral formulation of this drug was developed that makes oxymorphone a new option in treating moderate to severe pain. This article reviews the pharmacodynamics, pharmacology, and clinical efficacy for this new option in treating moderate to severe pain. JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer AU - Prommer, Eric AD - VIP Palliative Care Program Greater Los Angeles Healthcare, Division of Hematology/Oncology, UCLA School of Medicine, 11301 Wilshire 111-H, Los Angeles, CA, USA. eric.prommer@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 109 EP - 115 VL - 14 IS - 2 SN - 0941-4355, 0941-4355 KW - Analgesics, Opioid KW - 0 KW - Oxymorphone KW - 9VXA968E0C KW - Index Medicus KW - Drug Interactions KW - Drug Administration Schedule KW - Neoplasms -- complications KW - Humans KW - Oxymorphone -- adverse effects KW - Pain -- drug therapy KW - Oxymorphone -- pharmacokinetics KW - Analgesics, Opioid -- pharmacology KW - Oxymorphone -- pharmacology KW - Analgesics, Opioid -- therapeutic use KW - Oxymorphone -- therapeutic use KW - Oxymorphone -- administration & dosage KW - Analgesics, Opioid -- pharmacokinetics KW - Analgesics, Opioid -- adverse effects KW - Analgesics, Opioid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70689841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.atitle=Oxymorphone%3A+a+review.&rft.au=Prommer%2C+Eric&rft.aulast=Prommer&rft.aufirst=Eric&rft.date=2006-02-01&rft.volume=14&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.issn=09414355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-16 N1 - Date created - 2006-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatitis C and hospital outcomes in patients admitted with alcohol-related problems. AN - 70686874; 16226823 AB - Alcohol is known to act synergistically with chronic hepatitis C virus (HCV) infection to cause liver disease; however, their combined effect on outcomes in acutely hospitalized patients is less clear. We examined the impact of HCV infection on hospital mortality and length of stay among hospitalized patients with alcohol abuse problems. We retrospectively identified 6354 admissions to an urban, public hospital between July 1996 and January 2002 with discharge diagnoses related to alcohol dependence or abuse. Hepatitis C diagnosis and other information were extracted from a clinical database and tested for associations with death and length of hospital stay using multivariable regression techniques. The prevalence of diagnosed HCV infection in this sample of patients with alcohol abuse was 15%. Patients with HCV were about twice as likely to die during hospital admission (4.4 vs. 2.4%; P-value < 0.01), and there appeared to be a trend toward increased mortality even after adjustment for demographics, medical service, homelessness and comorbidities (fully adjusted OR 1.41; 95% CI: 0.97-2.04). Length of stay was significantly longer for patients with HCV (19% longer; 95% CI: 12-27% after adjustment) than those without. Patients admitted to the hospital with alcohol-related diagnoses have longer hospital stays and are more likely to die in hospital if they have a diagnosis of HCV. JF - Journal of hepatology AU - Tsui, Judith I AU - Pletcher, Mark J AU - Vittinghoff, Eric AU - Seal, Karen AU - Gonzales, Ralph AD - Division of General Medicine, General Internal Medicine Section (111A1), San Francisco Veteran Administration Medical Center, University of California, 4150 Clement Street, San Francisco, CA 94121, USA. judith.tsui@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 262 EP - 266 VL - 44 IS - 2 SN - 0168-8278, 0168-8278 KW - Index Medicus KW - Humans KW - Adult KW - Retrospective Studies KW - Prognosis KW - Middle Aged KW - California -- epidemiology KW - Male KW - Female KW - Prevalence KW - Length of Stay -- statistics & numerical data KW - Inpatients -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Hepatitis C, Chronic -- epidemiology KW - Hepatitis C, Chronic -- complications KW - Patient Admission -- statistics & numerical data KW - Hospital Mortality -- trends KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70686874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=Hepatitis+C+and+hospital+outcomes+in+patients+admitted+with+alcohol-related+problems.&rft.au=Tsui%2C+Judith+I%3BPletcher%2C+Mark+J%3BVittinghoff%2C+Eric%3BSeal%2C+Karen%3BGonzales%2C+Ralph&rft.aulast=Tsui&rft.aufirst=Judith&rft.date=2006-02-01&rft.volume=44&rft.issue=2&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=01688278&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-25 N1 - Date created - 2006-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug-associated renal dysfunction and injury. AN - 68791371; 16932399 AB - Renal dysfunction and injury secondary to medications are common, and can present as subtle injury and/or overt renal failure. Some drugs perturb renal perfusion and induce loss of filtration capacity. Others directly injure vascular, tubular, glomerular and interstitial cells, such that specific loss of renal function leads to clinical findings, including microangiopathy, Fanconi syndrome, acute tubular necrosis, acute interstitial nephritis, nephrotic syndrome, obstruction, nephrogenic diabetes insipidus, electrolyte abnormalities and chronic renal failure. Understanding the mechanisms involved, and recognizing the clinical presentations of renal dysfunction arising from use of commonly prescribed medications, are important if injury is to be detected early and prevented. This article reviews the clinical features and basic processes underlying renal injury related to the use of common drugs. JF - Nature clinical practice. Nephrology AU - Choudhury, Devasmita AU - Ahmed, Ziauddin AD - University of Texas Southwestern Medical Center, Dallas, TX, USA. devasmita.dev@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 80 EP - 91 VL - 2 IS - 2 SN - 1745-8323, 1745-8323 KW - Index Medicus KW - Humans KW - Renal Insufficiency -- chemically induced KW - Drug-Related Side Effects and Adverse Reactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68791371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+clinical+practice.+Nephrology&rft.atitle=Drug-associated+renal+dysfunction+and+injury.&rft.au=Choudhury%2C+Devasmita%3BAhmed%2C+Ziauddin&rft.aulast=Choudhury&rft.aufirst=Devasmita&rft.date=2006-02-01&rft.volume=2&rft.issue=2&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Nature+clinical+practice.+Nephrology&rft.issn=17458323&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-14 N1 - Date created - 2006-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lessons learned about implementing research evidence into clinical practice. Experiences from VA QUERI. AN - 67905777; 16637956 AB - The mission of the Veterans Health Administration's (VHA) quality enhancement research initiative (QUERI) is to enhance the quality of VHA health care by implementing clinical research findings into routine care. This paper presents lessons that QUERI investigators have learned through their initial attempts to pursue the QUERI mission. The lessons in this paper represent those that were common across multiple QUERI projects and were mutually agreed on as having substantial impact on the success of implementation. While the lessons are consistent with commonly recognized ingredients of successful implementation efforts, the examples highlight the fact that, even with a thorough knowledge of the literature and thoughtful planning, unexpected circumstances arise during implementation efforts that require flexibility and adaptability. The findings stress the importance of utilizing formative evaluation techniques to identify barriers to successful implementation and strategies to address these barriers. JF - Journal of general internal medicine AU - Hagedorn, Hildi AU - Hogan, Mary AU - Smith, Jeffrey L AU - Bowman, Candice AU - Curran, Geoffrey M AU - Espadas, Donna AU - Kimmel, Barbara AU - Kochevar, Laura AU - Legro, Marcia W AU - Sales, Anne E AD - Substance Use Disorders QUERI, Minneapolis VA Medical Center, Minneapolis, MN 55417, USA. Hildi.Hagedorn@va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - S21 EP - S24 VL - 21 Suppl 2 KW - Narcotics KW - 0 KW - Index Medicus KW - United States KW - Practice Patterns, Physicians' KW - United States Department of Veterans Affairs KW - Humans KW - Community Networks -- organization & administration KW - Narcotics -- therapeutic use KW - Narcotics -- agonists KW - Hospitals, Veterans -- standards KW - Benchmarking KW - Opioid-Related Disorders -- drug therapy KW - Practice Guidelines as Topic -- standards KW - Evidence-Based Medicine KW - Total Quality Management KW - Outcome Assessment (Health Care) -- methods KW - Health Services Research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67905777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+general+internal+medicine&rft.atitle=Lessons+learned+about+implementing+research+evidence+into+clinical+practice.+Experiences+from+VA+QUERI.&rft.au=Hagedorn%2C+Hildi%3BHogan%2C+Mary%3BSmith%2C+Jeffrey+L%3BBowman%2C+Candice%3BCurran%2C+Geoffrey+M%3BEspadas%2C+Donna%3BKimmel%2C+Barbara%3BKochevar%2C+Laura%3BLegro%2C+Marcia+W%3BSales%2C+Anne+E&rft.aulast=Hagedorn&rft.aufirst=Hildi&rft.date=2006-02-01&rft.volume=21+Suppl+2&rft.issue=&rft.spage=S21&rft.isbn=&rft.btitle=&rft.title=Journal+of+general+internal+medicine&rft.issn=1525-1497&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-09 N1 - Date created - 2006-04-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Jt Comm J Qual Patient Saf. 2005 Dec;31(12):700-7 [16430023] Milbank Q. 2004;82(4):581-629 [15595944] Worldviews Evid Based Nurs. 2004;1(2):129-39 [17129326] Worldviews Evid Based Nurs. 2004;1 Suppl 1:S33-40 [17129333] J Gen Intern Med. 2006 Feb;21 Suppl 2:S1-8 [16637954] Med Care. 2000 Jun;38(6 Suppl 1):I17-25 [10843267] Med Care. 2002 Dec;40(12):1270-82 [12458308] J Am Med Inform Assoc. 2004 Jan-Feb;11(1):50-9 [14527974] J Spinal Cord Med. 2003 Fall;26(3):210-8 [14997959] J Acquir Immune Defic Syndr. 2004 Mar 1;35(3):253-60 [15076239] Am J Med. 2004 Jun 1;116(11):732-9 [15144909] Drug Alcohol Depend. 2004 Jul 15;75(1):97-106 [15225893] J Am Med Inform Assoc. 2004 Sep-Oct;11(5):339-43 [15187071] J Am Med Inform Assoc. 2004 Sep-Oct;11(5):351-7 [15187073] Am J Med Qual. 2004 Jul-Aug;19(4):137-44 [15368778] Comment In: J Gen Intern Med. 2006 Feb;21 Suppl 2:S67-70 [16637964] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Palliative ethanol injections of unresectable advanced esophageal carcinoma combined with chemoradiation. AN - 67663950; 16479188 AB - Combined chemoradiation therapy has proven to be an effective treatment for unresectable esophageal cancer. Nonsurgical endoscopic palliation of local disease has become feasible with neodymium:yttrium-aluminum-garnet laser, BICAP tumor probe, and metallic stents. Alternatively, endoscopic injections of ethanol are safe, inexpensive, and useful for palliation of malignant dysphagia. Two patients with unresectable squamous cell carcinoma of the esophagus were treated with 1 mL of absolute (95 g/L) alcohol injections once a week for 4 weeks, followed by chemoradiation therapy consisting of concomitant 5-fluorouracil 300 mg/m/d and radiation therapy (total of 60 Gy over 6 weeks). One patient had a complete response but died of alcoholism 25 months after diagnosis without evidence of tumor recurrence. The other patient had a partial response but died 16 months after diagnosis from disease progression. We conclude that tumor ablation by ethanol injection for palliation combined with chemoradiation may be a low-cost alternative for advanced unresectable esophageal cancer. JF - The American journal of the medical sciences AU - Wadleigh, Robert G AU - Abbasi, Salah AU - Korman, Louis AD - Oncology Section, Department of Veterans Affairs Medical Center, Washington, DC, USA. Robert.Wadleigh@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 110 EP - 112 VL - 331 IS - 2 SN - 0002-9629, 0002-9629 KW - Antimetabolites, Antineoplastic KW - 0 KW - Ethanol KW - 3K9958V90M KW - Fluorouracil KW - U3P01618RT KW - Abridged Index Medicus KW - Index Medicus KW - Fluorouracil -- therapeutic use KW - Radiation Dosage KW - Fatal Outcome KW - Neoplasm Staging KW - Combined Modality Therapy KW - Humans KW - Aged KW - Middle Aged KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Male KW - Ethanol -- administration & dosage KW - Esophageal Neoplasms -- radiotherapy KW - Carcinoma, Squamous Cell -- radiotherapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Palliative Care -- methods KW - Ethanol -- therapeutic use KW - Esophageal Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67663950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Palliative+ethanol+injections+of+unresectable+advanced+esophageal+carcinoma+combined+with+chemoradiation.&rft.au=Wadleigh%2C+Robert+G%3BAbbasi%2C+Salah%3BKorman%2C+Louis&rft.aulast=Wadleigh&rft.aufirst=Robert&rft.date=2006-02-01&rft.volume=331&rft.issue=2&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-16 N1 - Date created - 2006-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Combination exposure to zidovudine plus sulfamethoxazole-trimethoprim diminishes B-lymphocyte immune responses to Pneumocystis murina infection in healthy mice. AN - 67644807; 16467325 AB - We have previously shown that zidovudine plus sulfamethoxazole-trimethoprim exposure decreases immune cell populations in the bone marrow of healthy mice by inducing apoptosis. The hypothesis of the current work was that this toxicity would have an adverse impact on the immune response. To determine this, BALB/c mice were treated with zidovudine, sulfamethoxazole-trimethoprim, the combination of both drugs, or vehicle only (control) via oral gavage for 21 days. On day 4 after dosing completion, the mice were infected intratracheally with 1x10(7) Pneumocystis murina organisms. Immune cell populations (in lung digest, bronchoalveolar lavage fluid, tracheobronchial lymph node, and bone marrow samples), the lung Pneumocystis burden, and serum Pneumocystis-specific antibody titers were determined at days 6, 10, and 20 postinfection. While total bone marrow cellularity was recovered by day 6 postinfection in the combination exposure group, B-cell numbers did not recover until 10 days postinfection, primarily due to the persistent depletion of the late pre-B-cell phenotype. The numbers of CD4+ and CD8+ T cells, as well as the numbers of total B cells and activated B cells in tracheobronchial lymph nodes, were decreased at days 10 and 20 as a result of zidovudine plus sulfamethoxazole-trimethoprim exposure compared to the numbers in the control group. No significant differences in lung lavage or lung digest cell populations were observed. There was a trend of a delay in Pneumocystis clearance in the combination treatment group, and Pneumocystis-specific serum immunoglobulin G titers were reduced at day 20 postinfection. Together, these data indicate that the combination of zidovudine and sulfamethoxazole-trimethoprim adversely affects the humoral immune response to Pneumocystis. JF - Clinical and vaccine immunology : CVI AU - Feola, David J AU - Garvy, Beth A AD - Department of Pharmacy Practice and Science, University of Kentucky Chandler Medical Center, and Veterans Administration Medical Center, Lexington, KY 40536-0298, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 193 EP - 201 VL - 13 IS - 2 SN - 1556-6811, 1556-6811 KW - Antibodies, Fungal KW - 0 KW - Immunoglobulin G KW - Zidovudine KW - 4B9XT59T7S KW - Trimethoprim, Sulfamethoxazole Drug Combination KW - 8064-90-2 KW - Index Medicus KW - Pneumocystis -- immunology KW - Lung -- immunology KW - Immunoglobulin G -- blood KW - Immune Tolerance -- drug effects KW - Animals KW - Drug Interactions KW - Mice KW - Antibodies, Fungal -- blood KW - Mice, Inbred BALB C KW - Bone Marrow -- drug effects KW - Lung -- microbiology KW - Trimethoprim, Sulfamethoxazole Drug Combination -- administration & dosage KW - B-Lymphocytes -- drug effects KW - Pneumonia, Pneumocystis -- immunology KW - Pneumonia, Pneumocystis -- drug therapy KW - Zidovudine -- toxicity KW - Pneumonia, Pneumocystis -- microbiology KW - B-Lymphocytes -- microbiology KW - Trimethoprim, Sulfamethoxazole Drug Combination -- toxicity KW - Zidovudine -- administration & dosage KW - B-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67644807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+vaccine+immunology+%3A+CVI&rft.atitle=Combination+exposure+to+zidovudine+plus+sulfamethoxazole-trimethoprim+diminishes+B-lymphocyte+immune+responses+to+Pneumocystis+murina+infection+in+healthy+mice.&rft.au=Feola%2C+David+J%3BGarvy%2C+Beth+A&rft.aulast=Feola&rft.aufirst=David&rft.date=2006-02-01&rft.volume=13&rft.issue=2&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Clinical+and+vaccine+immunology+%3A+CVI&rft.issn=15566811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-10 N1 - Date created - 2006-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet. 1989 Dec 2;2(8675):1294-8 [2574255] Health Phys. 1989;57 Suppl 1:405-9 [2606699] Science. 1990 Feb 2;247(4942):564-6 [2300816] N Engl J Med. 1990 Apr 5;322(14):941-9 [1969115] Ann Intern Med. 1990 May 15;112(10):727-37 [1970466] J Exp Med. 1990 Sep 1;172(3):937-45 [2117637] Drug Metab Dispos. 1990 Sep-Oct;18(5):784-7 [1981737] N Engl J Med. 1991 Apr 11;324(15):1018-25 [1672443] J Exp Med. 1991 May 1;173(5):1213-25 [1827140] Lancet. 1991 Aug 17;338(8764):431-3 [1678095] N Engl J Med. 1983 Jun 23;308(25):1535-6 [6222258] N Engl J Med. 1983 Aug 25;309(8):453-8 [6224088] JAMA. 1984 Mar 16;251(11):1447-9 [6608011] Ann Intern Med. 1984 Apr;100(4):495-9 [6230976] Ann Intern Med. 1984 May;100(5):663-71 [6231873] Am Rev Respir Dis. 1984 Dec;130(6):1174-6 [6508012] Clin Exp Pharmacol Physiol. 1995 Nov;22(11):851-4 [8593743] J Infect Dis. 1996 Apr;173(4):1034-7 [8603947] Med J Aust. 1996 Mar 4;164(5):290-5 [8628165] Infect Immun. 1996 Jun;64(6):1892-9 [8675284] Transplantation. 1996 Aug 27;62(4):517-25 [8781619] Infect Immun. 1996 Oct;64(10):3987-92 [8926059] Eur J Drug Metab Pharmacokinet. 1996 Jul-Sep;21(3):275-8 [8980928] J Clin Invest. 1997 May 1;99(9):2110-7 [9151783] AIDS Res Hum Retroviruses. 1997 Aug 10;13(12):1023-9 [9264289] Drug Metab Dispos. 1991 Sep-Oct;19(5):900-6 [1686233] J Protozool. 1991 Nov-Dec;38(6):44S-45S [1687826] J Clin Invest. 1992 Aug;90(2):673-8 [1353767] J Infect Dis. 1993 Jan;167(1):180-5 [8380290] Chest. 1993 Feb;103(2 Suppl):116S-118S [8094045] Clin Exp Immunol. 1993 Oct;94(1):21-5 [8403509] Am J Med. 1994 Jan;96(1):94-5 [8304370] Toxicol Appl Pharmacol. 1995 Mar;131(1):53-62 [7878678] Infect Immun. 1995 Jul;63(7):2391-5 [7790048] J Clin Pharmacol. 1995 Oct;35(10):957-66 [8568013] AIDS. 1999 Sep;13 Suppl 1:S49-59 [10546785] Toxicol Sci. 2000 Jun;55(2):335-42 [10828265] J Invest Dermatol. 2000 Jun;114(6):1164-73 [10844561] Ann Intern Med. 2000 Jul 4;133(1):35-9 [10877738] Comp Med. 2000 Feb;50(1):49-55 [10987669] J Immunol. 2000 Nov 15;165(10):5558-65 [11067910] Br J Pharmacol. 2001 May;133(2):295-305 [11350866] AIDS. 2001 Sep 7;15(13):1687-94 [11546944] J Clin Invest. 2001 Nov;108(10):1469-74 [11714738] N Engl J Med. 2002 Mar 14;346(11):811-20 [11893792] MMWR Recomm Rep. 2002 Jun 14;51(RR-8):1-52 [12081007] Mol Pharmacol. 2002 Sep;62(3):628-37 [12181439] MMWR CDC Surveill Summ. 1999 Apr 16;48(2):1-22 [12412613] J Mol Biol. 2003 May 23;329(1):45-57 [12742017] J Immunol. 2003 Jun 15;170(12):5965-72 [12794123] J Immunol. 2003 Aug 1;171(3):1423-30 [12874234] Infect Immun. 2003 Dec;71(12):6808-19 [14638767] Emerg Infect Dis. 2004 Oct;10(10):1713-20 [15504255] Chemotherapy. 1973;18(5):274-84 [4728201] Chemotherapy. 1974;20(6):321-30 [4442290] Antibiot Chemother (1971). 1974;18:148-98 [4463825] Infect Immun. 1997 Dec;65(12):5052-6 [9393795] BMJ. 1998 Apr 25;316(7140):1295-8 [9554902] J Clin Immunol. 1998 May;18(3):235-40 [9624583] Gen Pharmacol. 1998 Oct;31(4):531-8 [9792211] Lancet. 1998 Dec 12;352(9144):1919-22 [9863802] Br J Pharmacol. 1999 Mar;126(6):1393-407 [10217534] Int Immunopharmacol. 2005 Dec;5(13-14):1881-94 [16275623] J Pediatr. 1985 Sep;107(3):352-7 [4032129] Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7 [2430286] J Immunol. 1987 Jun 1;138(11):3720-4 [2953790] N Engl J Med. 1987 Jul 23;317(4):192-7 [3299090] Ann Intern Med. 1987 Oct;107(4):502-5 [3477107] Clin Exp Immunol. 1987 Jun;68(3):479-87 [3652522] Lab Invest. 1988 Mar;58(3):324-31 [3258045] J Clin Invest. 1988 Jun;81(6):1666-8 [2454947] Br J Haematol. 1988 Jul;69(3):299-304 [3261597] Exp Hematol. 1988 Dec;16(11):938-40 [3181343] J Infect Dis. 1988 Nov;158(5):983-90 [3183430] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hexosamines regulate sensitivity of glucose-stimulated insulin secretion in beta-cells. AN - 67616645; 16188910 AB - Hexosamines serve a nutrient-sensing function through enzymatic O-glycosylation of proteins. We previously characterized transgenic (Tg) mice with overexpression of the rate-limiting enzyme in hexosamine production, glutamine:fructose-6-phosphate amidotransferase, in beta-cells. Animals were hyperinsulinemic, resulting in peripheral insulin resistance. Glucose tolerance deteriorated with age, and males developed diabetes. We therefore examined islet function in these mice by perifusion in vitro. Young (2-mo-old) Tg animals had enhanced sensitivity to glucose of insulin secretion. Insulin secretion was maximal at 20 mM and half maximal at 9.9 +/- 0.5 mM glucose in Tg islets compared with maximal at 30 mM and half maximal at 13.5 +/- 0.7 mM glucose in wild type (WT; P < 0.005). Young Tg animals secreted more insulin in response to 20 mM glucose (Tg, 1,254 +/- 311; WT, 425 +/- 231 pg x islet(-1) x 35 min(-1); P < 0.01). Islets from older (8-mo-old) Tg mice became desensitized to glucose, with half-maximal secretion at 16.1 +/- 0.8 mM glucose, compared with 11.8 +/- 0.7 mM in WT (P < 0.05). Older Tg mice secreted less insulin in response to 20 mM glucose (Tg, 2,256 +/- 342; WT, 3,493 +/- 367 pg x islet(-1) x 35 min(-1); P < 0.05). Secretion in response to carbachol was similar in WT and Tg at both ages. Glucose oxidation was blunted in older Tg islets. At 5 mM glucose, islet CO2 production was comparable between Tg and WT. However, WT mice increased islet CO2 production 2.7 +/- 0.4-fold in 20 mM glucose, compared with only 1.4 +/- 0.1-fold in Tg (P < 0.02). Results demonstrate that hexosamines are involved in nutrient sensing for insulin secretion, acting at least in part by modulating glucose oxidation pathways. Prolonged excess hexosamine flux results in glucose desensitization and mimics glucose toxicity. JF - American journal of physiology. Endocrinology and metabolism AU - Cooksey, Robert C AU - Pusuluri, Sumitha AU - Hazel, Mark AU - McClain, Donald A AD - Veterans Administration Medical Center and Division of Endocrinology and Metabolism, University of Utah School of Medicine, 30 N. 2030 East, Salt Lake City, UT 84132, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - E334 EP - E340 VL - 290 IS - 2 SN - 0193-1849, 0193-1849 KW - Hexosamines KW - 0 KW - Insulin KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Mice, Transgenic -- metabolism KW - Animals KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Mice KW - Hexosamines -- metabolism KW - Hexosamines -- genetics KW - Insulin -- biosynthesis KW - Glucose -- metabolism KW - Insulin-Secreting Cells -- metabolism KW - Insulin Resistance -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67616645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Endocrinology+and+metabolism&rft.atitle=Hexosamines+regulate+sensitivity+of+glucose-stimulated+insulin+secretion+in+beta-cells.&rft.au=Cooksey%2C+Robert+C%3BPusuluri%2C+Sumitha%3BHazel%2C+Mark%3BMcClain%2C+Donald+A&rft.aulast=Cooksey&rft.aufirst=Robert&rft.date=2006-02-01&rft.volume=290&rft.issue=2&rft.spage=E334&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Endocrinology+and+metabolism&rft.issn=01931849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-22 N1 - Date created - 2006-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interdisciplinary Care Planning and the Written Care Plan in Nursing Homes: A Critical Review AN - 61403918; 200704602 AB - Purpose: This article is a critical review of the history, research evidence, & state-of-the-art technology in interdisciplinary care planning & the written plan of care in American nursing homes. Design and Methods: We reviewed educational & empirical literature. Results: Interdisciplinary care planning & the written care plan are mandated processes that are imbedded in the regulatory fabric & routines of the American nursing home. These processes evolved from the discipline of nursing, where care planning has had a long & controversial history. Implications: Practice implications are provided. References. Adapted from the source document. JF - The Gerontologist AU - Dellefield, Mary Ellen AD - VA San Diego Medical Center, CA mary.dellefield@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 128 EP - 133 PB - Gerontological Society of America, Washington DC VL - 46 IS - 1 SN - 0016-9013, 0016-9013 KW - Care plan, Clinical documentation, Interdisciplinary practice, Nursing home, Coordinating care KW - Documentation KW - Coordination KW - Planning KW - United States of America KW - Interdisciplinary Approach KW - Nursing Homes KW - Health Care Services KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61403918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=Interdisciplinary+Care+Planning+and+the+Written+Care+Plan+in+Nursing+Homes%3A+A+Critical+Review&rft.au=Dellefield%2C+Mary+Ellen&rft.aulast=Dellefield&rft.aufirst=Mary&rft.date=2006-02-01&rft.volume=46&rft.issue=1&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-11-01 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Nursing Homes; Health Care Services; Planning; Documentation; Interdisciplinary Approach; Coordination; United States of America ER - TY - JOUR T1 - Rasch Modeling of Revised Token Test Performance: Validity and Sensitivity to Change AN - 57122208; 200702393 AB - The purpose of this research was to examine the validity of the 55-item Revised Token Test (RTT) & to compare traditional & Rasch-based scores in their ability to detect group differences & change over time. The 55-item RTT was administered to 108 left- & right-hemisphere stroke survivors, & the data were submitted to Rasch analysis. Traditional & Rasch-based scores for a subsample of 60 stroke survivors were submitted to analyses of variance with group (left hemisphere with aphasia vs. right hemisphere) & time post onset (3 vs. 6 months post onset) as factors. The 2 scoring methods were compared using an index of relative precision. Forty-eight items demonstrated acceptable model fit. Misfitting items came primarily from Subtest IX. The Rasch model accounted for 71% of the variance in the responses to the remaining items. Intersubtest patterns of item difficulty were well predicted by item content, but unexpected within-subtest differences were found. Both traditional & Rasch person scores demonstrated significant group differences, but only the latter demonstrated statistically significant change over time. Analysis of relative precision, however, failed to confirm a significant difference between the 2 methods. The findings generally support the RTT's validity, but a minority of items appears to respond to a different construct. Also, within-subtest differences in item difficulty suggest the need for further examination of variability in impaired language performance. Finally, the results suggest an equivocal advantage for Rasch scores in detecting change over time. Tables, Figures, References. Adapted from the source document. JF - Journal of Speech, Language, and Hearing Research AU - Hula, William AU - Doyle, Patrick J AU - McNeil, Malcolm R AU - Mikolic, Joseph M AD - VA Pittsburgh Healthcare System, PA william.hula@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 27 EP - 46 PB - American Speech-Language-Hearing Association, Rockville MD VL - 49 IS - 1 SN - 1092-4388, 1092-4388 KW - assessment, aphasia, auditory comprehension, spoken language comprehension assessment, standardized assessment KW - Assessment KW - Rasch model KW - Language skills KW - Aphasia KW - Strokes KW - Validity studies KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57122208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=Rasch+Modeling+of+Revised+Token+Test+Performance%3A+Validity+and+Sensitivity+to+Change&rft.au=Hula%2C+William%3BDoyle%2C+Patrick+J%3BMcNeil%2C+Malcolm+R%3BMikolic%2C+Joseph+M&rft.aulast=Hula&rft.aufirst=William&rft.date=2006-02-01&rft.volume=49&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/10.1044%2F1092-4388%282006%2F003%29 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-02-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Validity studies; Rasch model; Aphasia; Strokes; Language skills; Assessment DO - http://dx.doi.org/10.1044/1092-4388(2006/003) ER - TY - JOUR T1 - Anti-Interleukin-15 Prevents Arthritis in Borrelia-Vaccinated and -Infected Mice AN - 19940783; 6718591 AB - We showed previously that interleukin-17 (IL-17) plays a significant role in the induction of arthritis associated with Borrelia vaccination and challenge. Little information, however, is available about the chain of immunologic events that leads to the release of IL-17. The production of IL-17 has been linked to stimulation of memory cells by IL-15. Therefore, we hypothesized that IL-15 is involved in the induction of arthritis associated with Borrelia vaccination and infection of mice. Here we present evidence that treatment of Borrelia-vaccinated and -infected mice with anti-IL-15 antibody prevents swelling of the hind paws. More importantly, both anti-IL-15 antibody- and recombinant IL-15 receptor alpha-treated Borrelia-vaccinated and -infected mice were free of major histopathologic indications of arthritis, including hyperplasia, hypertrophy, and vilus formation of the synovium. Similarly, the synovial space and perisynovium were free of inflammatory cells. By contrast, the synovium of nontreated Borrelia-vaccinated and -infected mice had overt hyperplasia, hypertrophy, and vilus formation. Moreover, the synovial space and perisynovium were infiltrated with neutrophils, macrophages, and lymphocytes. Finally, we show that recombinant IL-15 stimulates the release of IL-17 from lymph node cells obtained near the arthritic site. These results suggest that IL-15 plays a major role in orchestrating IL-17 induction of arthritis associated with Borrelia-vaccinated and -infected mice. JF - Clinical and Vaccine Immunology AU - Amlong, Corey A AU - Nardelli, Dean T AU - Peterson, Sara Heil AU - Warner, Thomas F AU - Callister, Steven M AU - Schell, Ronald F AD - Wisconsin State Laboratory of Hygiene. Department of Bacteriology. Department of Comparative Biomedical Sciences. Department of Medical Microbiology and Immunology, University of Wisconsin. Department of Pathology, Veterans Administration Hospital, Madison. Microbiology Research Laboratory and Section of Infectious Diseases, Gundersen Lutheran Medical Center, La Crosse, Wisconsin Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 289 EP - 296 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 13 IS - 2 SN - 1556-6811, 1556-6811 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Interleukin 15 receptors KW - Synovium KW - Memory cells KW - Leukocytes (neutrophilic) KW - Lymphocytes KW - Infection KW - Vaccination KW - Lymph nodes KW - Inflammation KW - Antibodies KW - Hypertrophy KW - Hyperplasia KW - Interleukin 15 KW - Arthritis KW - Interleukin 17 KW - Borrelia KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19940783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Anti-Interleukin-15+Prevents+Arthritis+in+Borrelia-Vaccinated+and+-Infected+Mice&rft.au=Amlong%2C+Corey+A%3BNardelli%2C+Dean+T%3BPeterson%2C+Sara+Heil%3BWarner%2C+Thomas+F%3BCallister%2C+Steven+M%3BSchell%2C+Ronald+F&rft.aulast=Amlong&rft.aufirst=Corey&rft.date=2006-02-01&rft.volume=13&rft.issue=2&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; Interleukin 15 receptors; Synovium; Leukocytes (neutrophilic); Memory cells; Lymphocytes; Infection; Vaccination; Lymph nodes; Inflammation; Hyperplasia; Hypertrophy; Antibodies; Interleukin 15; Interleukin 17; Arthritis; Borrelia ER - TY - JOUR T1 - Toll-Like Receptor 4 Protects against Lethal Leptospira interrogans Serovar Icterohaemorrhagiae Infection and Contributes to In Vivo Control of Leptospiral Burden AN - 17473333; 6660899 AB - The roles of innate immune responses in protection from or pathogenesis of severe leptospirosis remain unclear. We examined the role of Toll-like receptors (TLRs) in mouse infection and macrophage responses to LEPTOSPIRA: C3H/HeJ mice (TLR4 deficient) and C3H/HeJ-SCID mice, but not C3H/OuJ mice (TLR4 intact), died after intraperitoneal infection with Leptospira interrogans serovar Icterohaemorrhagiae. Death in both C3H/HeJ mouse strains was associated with jaundice and pulmonary hemorrhage, similar to the patient from whom the isolate was obtained. In chronic sublethal infection, TLR4-deficient mice harbored more leptospires in liver, lung, and kidney than control mice. Heat-killed Leptospira stimulated macrophages to secrete proinflammatory cytokines, tumor necrosis factor alpha, interleukin-6, and macrophage inflammatory protein 2 not inhibited by polymyxin B, suggesting that leptospiral lipopolysaccharide (LPS) did not drive these responses. Anti-TLR4 and anti-MD-2 but not anti-CD14 monoclonal antibodies inhibited cytokine production. Peritoneal macrophages from CD14 super(-/-) and TLR2 super(-/-) mice exhibited no defect in cytokine responses to Leptospira compared to controls. Macrophages from C3H/HeJ, TLR4 super(-/-), and MyD88 super(-/-) mice secreted far-lower levels of cytokines than wild-type macrophages in response to LEPTOSPIRA: TLR4 plays a crucial role in protection from acute lethal infection and control of leptospiral burden during sublethal chronic infection. Cytokine responses in macrophages correlated with leptospiral clearance. These TLR4-dependent but CD14/TLR2-independent responses are likely mediated by a leptospiral ligand(s) other than LPS. JF - Infection and Immunity AU - Viriyakosol, Suganya AU - Matthias, Michael A AU - Swancutt, Mark A AU - Kirkland, Theo N AU - Vinetz, Joseph M AD - Division of Infectious Diseases, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0640. Veterans Administration San Diego Healthcare System and Department of Pathology, University of California, San Diego, 3350 La Jolla Village Drive, La Jolla, California 92161 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 887 EP - 895 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 2 SN - 0019-9567, 0019-9567 KW - mice KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - macrophage inflammatory protein 2 KW - Leptospirosis KW - polymyxin B KW - Hemorrhage KW - Leptospira interrogans KW - Lung KW - Kidney KW - Lipopolysaccharides KW - Cytokines KW - Tumor necrosis factor- alpha KW - TLR4 protein KW - Toll-like receptors KW - F 06106:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17473333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Toll-Like+Receptor+4+Protects+against+Lethal+Leptospira+interrogans+Serovar+Icterohaemorrhagiae+Infection+and+Contributes+to+In+Vivo+Control+of+Leptospiral+Burden&rft.au=Viriyakosol%2C+Suganya%3BMatthias%2C+Michael+A%3BSwancutt%2C+Mark+A%3BKirkland%2C+Theo+N%3BVinetz%2C+Joseph+M&rft.aulast=Viriyakosol&rft.aufirst=Suganya&rft.date=2006-02-01&rft.volume=74&rft.issue=2&rft.spage=887&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; macrophage inflammatory protein 2; Leptospirosis; Lung; Kidney; Cytokines; Lipopolysaccharides; Tumor necrosis factor- alpha; polymyxin B; Hemorrhage; TLR4 protein; Toll-like receptors; Leptospira interrogans ER - TY - JOUR T1 - Pathogenesis of B-Cell Superantigen-Induced Immune Complex-Mediated Inflammation AN - 17465727; 6660857 AB - Staphylococcal protein A (SpA) is representative of a new class of antigens, the B-cell superantigens (SAgs). These antigens bind to the Fab regions of immunoglobulin molecules outside their complementarity-determining regions. SpA, the best-studied B-cell SAg, reacts with the Fabs of most V sub(H)3 super(+) immunoglobulins, which are expressed on 30 to 60% of human peripheral B cells. Therefore, B-cell SAgs like SpA have great potential to elicit inflammatory responses in vivo. We previously reported that the interaction of SpA with V sub(H)3 super(+) immunoglobulin molecules leads to activation of the complement cascade and produces a histologic pattern of inflammation in the skin of a rabbit indicative of immune complex injury. To elucidate the cellular and molecular events contributing to this type of unconventional immune complex-mediated inflammation, we established a mouse peritoneal Arthus reaction model. Mice treated intravenously with human polyclonal immunoglobulin G (IgG), followed by intraperitoneal injection of SpA, showed neutrophil influx into the peritoneal cavity with peak numbers appearing at 8 h. This inflammatory reaction was dependent on the interaction of SpA with V sub(H)3 super(+) IgG. Mast cells, Fc gamma RIII, complement components, and tumor necrosis factor alpha play obligatory roles, and the reaction is associated with the local release of the CXC chemokines macrophage inflammatory protein 2 and KC. The data provide further compelling evidence for the induction of immune complex-mediated injury by a B-cell SAg and highlight important factors contributing to the pathogenesis of this novel type of inflammatory reaction. JF - Infection and Immunity AU - Anderson, Amy L AU - Sporici, Romeo AU - Lambris, John AU - LaRosa, David AU - Levinson, Arnold I AD - Allergy and Immunology Section, Philadelphia Veterans' Administration Medical Center. Department of Laboratory Medicine and Pathology. Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 1196 EP - 1203 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 2 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Arthus reaction KW - macrophage inflammatory protein 2 KW - CXC chemokines KW - Lymphocytes B KW - Antigen-antibody complexes KW - Leukocytes (neutrophilic) KW - Mast cells KW - Inflammation KW - Complement activation KW - Immunoglobulin G KW - complementarity-determining region KW - Tumor necrosis factor- alpha KW - F 06106:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17465727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Pathogenesis+of+B-Cell+Superantigen-Induced+Immune+Complex-Mediated+Inflammation&rft.au=Anderson%2C+Amy+L%3BSporici%2C+Romeo%3BLambris%2C+John%3BLaRosa%2C+David%3BLevinson%2C+Arnold+I&rft.aulast=Anderson&rft.aufirst=Amy&rft.date=2006-02-01&rft.volume=74&rft.issue=2&rft.spage=1196&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Arthus reaction; CXC chemokines; macrophage inflammatory protein 2; Lymphocytes B; Antigen-antibody complexes; Complement activation; Leukocytes (neutrophilic); Immunoglobulin G; Mast cells; complementarity-determining region; Tumor necrosis factor- alpha; Inflammation ER - TY - JOUR T1 - Respiratory Syncytial Virus Induces TLR3 Protein and Protein Kinase R, Leading to Increased Double-Stranded RNA Responsiveness in Airway Epithelial Cells AN - 17458195; 6662059 AB - Respiratory syncytial virus (RSV) preferentially infects airway epithelial cells, causing bronchiolitis, upper respiratory infections, asthma exacerbations, chronic obstructive pulmonary disease exacerbations, and pneumonia in immunocompromised hosts. A replication intermediate of RSV is dsRNA. This is an important ligand for both the innate immune receptor, TLR3, and protein kinase R (PKR). One known effect of RSV infection is the increased responsiveness of airway epithelial cells to subsequent bacterial ligands (i.e., LPS). In this study, we examined a possible role for RSV infection in increasing amounts and responsiveness of another TLR, TLR3. These studies demonstrate that RSV infection of A549 and human tracheobronchial epithelial cells increases the amounts of TLR3 and PKR in a time-dependent manner. This leads to increased NF- Kappa B activity and production of the inflammatory cytokine IL-8 following a later exposure to dsRNA. Importantly, TLR3 was not detected on the cell surface at baseline but was detected on the cell surface after RSV infection. The data demonstrate that RSV, via an effect on TLR3 and PKR, sensitizes airway epithelial cells to subsequent dsRNA exposure. These findings are consistent with the hypothesis that RSV infection sensitizes the airway epithelium to subsequent viral and bacterial exposures by up-regulating TLRs and increasing their membrane localization. JF - Journal of Immunology AU - Groskreutz, Dayna J AU - Monick, Martha M AU - Powers, Linda S AU - Yarovinsky, Timur O AU - Look, Dwight C AU - Hunninghake, Gary W AD - Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242 Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 1733 EP - 1740 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 176 IS - 3 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Cell surface KW - Epithelial cells KW - eIF-2 kinase KW - Data processing KW - Replication KW - Double-stranded RNA KW - Asthma KW - Infection KW - Interleukin 8 KW - NF- Kappa B protein KW - Chronic obstructive pulmonary disease KW - Inflammation KW - Respiratory syncytial virus KW - TLR3 protein KW - protein kinase R KW - Immunocompromised hosts KW - Chronic infection KW - Lipopolysaccharides KW - Epithelium KW - Pneumonia KW - Toll-like receptors KW - Bronchopneumonia KW - Respiratory tract KW - V 22099:Immune response & immune mechanisms KW - F 06302:Clinical: Immediate KW - J 02350:Immunology KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17458195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Respiratory+Syncytial+Virus+Induces+TLR3+Protein+and+Protein+Kinase+R%2C+Leading+to+Increased+Double-Stranded+RNA+Responsiveness+in+Airway+Epithelial+Cells&rft.au=Groskreutz%2C+Dayna+J%3BMonick%2C+Martha+M%3BPowers%2C+Linda+S%3BYarovinsky%2C+Timur+O%3BLook%2C+Dwight+C%3BHunninghake%2C+Gary+W&rft.aulast=Groskreutz&rft.aufirst=Dayna&rft.date=2006-02-01&rft.volume=176&rft.issue=3&rft.spage=1733&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Cell surface; Data processing; eIF-2 kinase; Replication; Double-stranded RNA; Asthma; Infection; Interleukin 8; Inflammation; Chronic obstructive pulmonary disease; NF- Kappa B protein; protein kinase R; TLR3 protein; Immunocompromised hosts; Chronic infection; Lipopolysaccharides; Epithelium; Bronchopneumonia; Toll-like receptors; Pneumonia; Respiratory tract; Respiratory syncytial virus ER - TY - JOUR T1 - Lower Extremity Physical Performance and Use of Compensatory Strategies for Mobility AN - 17155027; 6764745 AB - OBJECTIVES: To compare measured lower extremity physical performance in the clinic with the methods used to carry out mobility tasks at home and to identify key factors influencing day-to-day task performance. DESIGN: Cross-sectional analysis of the Women's Health and Aging Study I. SETTING: Community-dwelling female residents of Baltimore, Maryland. PARTICIPANTS: One thousand two cognitively intact women aged 65 and older with moderate to severe physical limitations. MEASUREMENTS: Compensatory strategies reportedly used for mobility in the home, distinguishing between use of no compensatory strategies, behavioral changes only, durable medical equipment (DME) with or without behavioral change, and human help; measured lower extremity (LE) physical performance (gait speed, timed chair stands, balance). RESULTS: There was a statistically significant difference in LE physical performance between women using the four types of compensatory strategy (P<.001). Women who used DME for mobility in the home had worse performance than those using human help who in turn had worse performance than those with behavioral changes only; women reporting no compensatory strategies for in-home mobility performed best. Sequential multivariate logistic regressions identified several factors other than LE physical performance that were associated with use of specific compensatory strategies. Medical conditions, education, and environmental barriers influenced whether compensatory strategies were used at all, whereas income, contact with health providers, and availability of help in the home influenced the type of compensatory strategy. CONCLUSION: Physical abilities are an important factor influencing use of compensatory strategies for mobility, but several other factors also influence the ways that women adapt to mobility limitations. JF - Journal of the American Geriatrics Society AU - Hoenig, Helen AU - Ganesh, Shanti Portia AU - Taylor, Donald H AU - Pieper, Carl AU - Guralnik, Jack AU - Fried, Linda P AD - Helen Hoenig, Rehabilitation Service, 508 Fulton Street, Durham, NC 27705, helen.hoenig@med.va.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 262 EP - 269 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 54 IS - 2 SN - 0002-8614, 0002-8614 KW - Physical Education Index KW - disability measurement KW - mobility KW - assistive technology KW - history of medicine KW - activities of daily living KW - Measurement KW - Statistics KW - Home KW - Equipment KW - Barriers KW - Women KW - Strategy KW - Gerontology KW - Health KW - Legs KW - Movement KW - Education KW - Speed KW - Analysis KW - Geriatrics KW - Performance KW - Gait KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17155027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Lower+Extremity+Physical+Performance+and+Use+of+Compensatory+Strategies+for+Mobility&rft.au=Hoenig%2C+Helen%3BGanesh%2C+Shanti+Portia%3BTaylor%2C+Donald+H%3BPieper%2C+Carl%3BGuralnik%2C+Jack%3BFried%2C+Linda+P&rft.aulast=Hoenig&rft.aufirst=Helen&rft.date=2006-02-01&rft.volume=54&rft.issue=2&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2005.00588.x LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - SuppNotes - Figures, 2; tables, 4; references, 31. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Measurement; Barriers; Equipment; Home; Statistics; Strategy; Women; Gerontology; Legs; Health; Movement; Speed; Education; Analysis; Geriatrics; Performance; Gait DO - http://dx.doi.org/10.1111/j.1532-5415.2005.00588.x ER - TY - JOUR T1 - Toll-like receptors, inflammation and cancer AN - 17095567; 6722001 AB - Toll-like receptors (TLRs) play a crucial role in the host defense against invading microorganisms by recognizing pathogen-associated molecular patterns (PAMPs). The anti-cancer effects of a number of microbial components, that have been used as adjuvants for the immunotherapy of cancers, are mediated through TLR signaling. However, cancer immunotherapy is not always successful because of the immunosuppression associated with cancer progression. Recently, a number of endogenous molecules have been reported to be ligands of TLRs. It has been suggested that the release of these putative endogenous ligands of TLRs during cancer progression may cause chronic inflammation leading to the recruitment of myeloid suppressor cells and down-regulation of T-cell and natural killer (NK) cell receptor zeta ( direct sum ) chain resulting in T and NK cell dysfunction. However, the reported putative endogenous TLR ligands may have been contaminated with PAMPs. Further studies are necessary to define the existence of endogenous TLR ligands and their potential contribution to the immunosuppression in cancer. JF - Seminars in Cancer Biology AU - Tsan, M F AD - Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA, min-fu.tsan2@med.va.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 32 EP - 37 VL - 16 IS - 1 SN - 1044-579X, 1044-579X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Immunotherapy KW - Natural killer cells KW - Lymphocytes T KW - Microorganisms KW - Suppressor cells KW - Adjuvants KW - Toll-like receptors KW - Cancer KW - Inflammation KW - Immunosuppression KW - Signal transduction KW - A 01490:Miscellaneous KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17095567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Cancer+Biology&rft.atitle=Toll-like+receptors%2C+inflammation+and+cancer&rft.au=Tsan%2C+M+F&rft.aulast=Tsan&rft.aufirst=M&rft.date=2006-02-01&rft.volume=16&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Cancer+Biology&rft.issn=1044579X&rft_id=info:doi/10.1016%2Fj.semcancer.2005.07.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Immunotherapy; Microorganisms; Lymphocytes T; Natural killer cells; Suppressor cells; Adjuvants; Cancer; Toll-like receptors; Signal transduction; Immunosuppression; Inflammation DO - http://dx.doi.org/10.1016/j.semcancer.2005.07.004 ER - TY - JOUR T1 - Hypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the Research on Adverse Drug Events and Reports (RADAR) project. AN - 67600390; 16386683 AB - We undertook the review of all available cases of hypersensitivity reactions after placement of a drug-eluting stent (DES) and classified potential causes. Six months after the approval of the first DES, the Food and Drug Administration (FDA) reported 50 hypersensitivity reactions after stent placement but later concluded these were due to concomitantly prescribed medications such as clopidogrel. Nevertheless, the FDA continued to receive reports of hypersensitivity. Reports available from April 2003 through December 2004 for hypersensitivity-like reactions associated with the sirolimus-eluting stent (CYPHER, Cordis Corp., Miami Lakes, Florida) and paclitaxel-eluting stent (TAXUS, Boston Scientific Corp., Natick, Massachusetts) were reviewed. Sources of reports included the FDA's adverse-device-event database, the published literature, and investigators from the Research on Adverse Drug/Device events And Reports (RADAR) project. Causality was assessed using standardized World Health Organization criteria. Of 5,783 reports identified for the DES in the FDA database, 262 unique events included hypersensitivity symptoms. Of these reports, 2 were certainly and 39 unlikely caused by clopidogrel and 1 was certainly, 9 probably, and 13 unlikely caused by the DES. From all sources, we identified 17 distinct cases that were probably or certainly caused by the stent, of which 9 had symptoms that lasted longer than four weeks. Four autopsies confirmed intrastent eosinophilic inflammation, thrombosis, and lack of intimal healing. The FDA reports and autopsy findings suggest that DES may be a cause of systemic and intrastent hypersensitivity reactions that, in some cases, have been associated with late thrombosis and death. JF - Journal of the American College of Cardiology AU - Nebeker, Jonathan R AU - Virmani, Renu AU - Bennett, Charles L AU - Hoffman, Jennifer M AU - Samore, Matthew H AU - Alvarez, Jorge AU - Davidson, Charles J AU - McKoy, June M AU - Raisch, Dennis W AU - Whisenant, Brian K AU - Yarnold, Paul R AU - Belknap, Steven M AU - West, Dennis P AU - Gage, Jonathan E AU - Morse, Richard E AU - Gligoric, Gordana AU - Davidson, Laura AU - Feldman, Marc D AD - Veterans Administration Salt Lake City, Salt Lake City, Utah, USA. Jonathan.Nebeker@hsc.utah.edu Y1 - 2006/01/03/ PY - 2006 DA - 2006 Jan 03 SP - 175 EP - 181 VL - 47 IS - 1 KW - Paclitaxel KW - P88XT4IS4D KW - Sirolimus KW - W36ZG6FT64 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Sirolimus -- adverse effects KW - Paclitaxel -- adverse effects KW - Coronary Vessels KW - Drug Hypersensitivity -- etiology KW - Stents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67600390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Hypersensitivity+cases+associated+with+drug-eluting+coronary+stents%3A+a+review+of+available+cases+from+the+Research+on+Adverse+Drug+Events+and+Reports+%28RADAR%29+project.&rft.au=Nebeker%2C+Jonathan+R%3BVirmani%2C+Renu%3BBennett%2C+Charles+L%3BHoffman%2C+Jennifer+M%3BSamore%2C+Matthew+H%3BAlvarez%2C+Jorge%3BDavidson%2C+Charles+J%3BMcKoy%2C+June+M%3BRaisch%2C+Dennis+W%3BWhisenant%2C+Brian+K%3BYarnold%2C+Paul+R%3BBelknap%2C+Steven+M%3BWest%2C+Dennis+P%3BGage%2C+Jonathan+E%3BMorse%2C+Richard+E%3BGligoric%2C+Gordana%3BDavidson%2C+Laura%3BFeldman%2C+Marc+D&rft.aulast=Nebeker&rft.aufirst=Jonathan&rft.date=2006-01-03&rft.volume=47&rft.issue=1&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=1558-3597&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-27 N1 - Date created - 2006-01-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Am Coll Cardiol. 2006 Aug 1;48(3):592-3; author reply 593-4 [16875994] J Am Coll Cardiol. 2006 Jan 3;47(1):182-3 [16386684] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Patient-Reported Outcome Measures: Use in Evaluation of Treatment for Aphasia AN - 85665884; 200701885 AB - Properties of patient-reported outcome instruments for the evaluation of therapy are reviewed, & three scales designed especially for use by aphasic patients are described in summary form. References. J. Hitchcock JF - Journal of Medical Speech-Language Pathology AU - Ross, Katherine B AD - Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ katherine.ross2@va.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - ix EP - xi VL - 14 IS - 3 SN - 1065-1438, 1065-1438 KW - Diagnosis (18540) KW - Language Therapy (44400) KW - Aphasia (03400) KW - Self Evaluation (76550) KW - Measures (Instruments) (52300) KW - Speech Therapy (83200) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85665884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Speech-Language+Pathology&rft.atitle=Patient-Reported+Outcome+Measures%3A+Use+in+Evaluation+of+Treatment+for+Aphasia&rft.au=Ross%2C+Katherine+B&rft.aulast=Ross&rft.aufirst=Katherine&rft.date=2006-01-01&rft.volume=14&rft.issue=3&rft.spage=ix&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Speech-Language+Pathology&rft.issn=10651438&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2007-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSLPEP N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Speech Therapy (83200); Language Therapy (44400); Self Evaluation (76550); Measures (Instruments) (52300); Diagnosis (18540) ER - TY - JOUR T1 - A 5-year prospective study of diabetes and hearing loss in a veteran population. AN - 85400973; pmid-16371845 AB - Veterans with diabetes will have significantly greater hearing loss than nondiabetic veterans.The association between diabetes and hearing loss remains unclear despite the volume of research that has been devoted to the question. Often, differences in hearing thresholds between diabetic and nondiabetic patients are confounded by age and noise exposure.In this 5-year prospective study, 342 diabetic veterans and 352 nondiabetic veterans from the Portland VA Medical Center in Oregon were tested on a variety of audiometric measures, including pure-tone thresholds.Age and noise exposure were accounted for in the analyses. There was a trend toward greater hearing loss in diabetic patients 60 years of age and younger across the frequency range. These differences were statistically significant only in the highest frequencies tested (10, 12.5, 14, and 16 kHz). The effects of both diabetes and noise exposure on high-frequency hearing thresholds were dependent on age. For patients older than 60 years, the mean thresholds were not significantly different.These results suggest that diabetic patients 60 years old or younger may show early high-frequency hearing loss similar to early presbycusis. After age 60, difference in hearing loss between diabetic and nondiabetic patients was reduced. JF - Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology AU - Vaughan, Nancy AU - James, Kenneth AU - McDermott, Daniel AU - Griest, Susan AU - Fausti, Stephen AD - National Center for Rehabilitative Auditory Research, Portland Veterans Affairs Medical Center and, Portland, Oregon 97239, USA. Nancy.Vaughan@med.va.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 37 EP - 43 VL - 27 IS - 1 SN - 1531-7129, 1531-7129 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Age Factors KW - Aged KW - Aged, 80 and over KW - Audiometry, Pure-Tone KW - *Auditory Threshold KW - Diabetes Complications: physiopathology KW - Female KW - Hearing Loss, Sensorineural: diagnosis KW - *Hearing Loss, Sensorineural: etiology KW - Humans KW - Male KW - Middle Aged KW - Noise: adverse effects KW - Prospective Studies KW - *Veterans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85400973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otology+%26+neurotology+%3A+official+publication+of+the+American+Otological+Society%2C+American+Neurotology+Society+%5Band%5D+European+Academy+of+Otology+and+Neurotology&rft.atitle=A+5-year+prospective+study+of+diabetes+and+hearing+loss+in+a+veteran+population.&rft.au=Vaughan%2C+Nancy%3BJames%2C+Kenneth%3BMcDermott%2C+Daniel%3BGriest%2C+Susan%3BFausti%2C+Stephen&rft.aulast=Vaughan&rft.aufirst=Nancy&rft.date=2006-01-01&rft.volume=27&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Otology+%26+neurotology+%3A+official+publication+of+the+American+Otological+Society%2C+American+Neurotology+Society+%5Band%5D+European+Academy+of+Otology+and+Neurotology&rft.issn=15317129&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Swallowing lateralization: the effects of modified dual-task interference. AN - 85397759; pmid-16544089 AB - A modified dual-task paradigm was designed to learn whether swallowing functions are selectively mediated by the left or right hemisphere. Healthy right-handed men (N = 38) were studied using videofluoroscopy to examine continuous straw drinking at baseline and with three interference conditions (silent word repetition, line orientation, finger tapping). Results indicate that activation of both right and left hemispheres can interfere with some swallowing behaviors. Findings suggest possibly different roles of the two hemispheres in the mediation of swallowing and support the notion that specific components of swallowing may be preferentially mediated by the left versus the right hemisphere. JF - Dysphagia AU - Daniels, Stephanie K AU - Corey, David M AU - Fraychinaud, April AU - DePolo, Asha AU - Foundas, Anne L AD - Research Service, Department of Veterans Affairs Medical Center, New Orleans, Louisiana 70112-1262, USA. stephanie.daniels@med.va.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 21 EP - 27 VL - 21 IS - 1 SN - 0179-051X, 0179-051X KW - Index Medicus KW - National Library of Medicine KW - Analysis of Variance KW - *Deglutition: physiology KW - Deglutition Disorders: physiopathology KW - Dominance, Cerebral: physiology KW - Fluoroscopy KW - *Functional Laterality: physiology KW - Humans KW - Male KW - Middle Aged KW - Positron-Emission Tomography KW - Task Performance and Analysis KW - Video Recording UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85397759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dysphagia&rft.atitle=Swallowing+lateralization%3A+the+effects+of+modified+dual-task+interference.&rft.au=Daniels%2C+Stephanie+K%3BCorey%2C+David+M%3BFraychinaud%2C+April%3BDePolo%2C+Asha%3BFoundas%2C+Anne+L&rft.aulast=Daniels&rft.aufirst=Stephanie&rft.date=2006-01-01&rft.volume=21&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Dysphagia&rft.issn=0179051X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Lifetime histories of trauma among pathological gamblers. AN - 70726409; 16449091 AB - This study extends the work completed with pathological gamblers and substance abusers, looking at associations between a history of trauma and comorbid substance dependence, impulsivity, measures of problem severity, and personality variables. We studied 111 patients admitted to the gambling treatment program at the Brecksville VA Medical Center and found that 64% of gamblers reported a history of emotional trauma; 40.5%, physical trauma; and 24.3%, sexual trauma. Most of this trauma occurred in childhood. A history of trauma was associated with a greater relative frequency of suicide attempts and drug and alcohol dependence, more severe scores in measures of psychiatric distress, and limited effects on personality functioning. JF - The American journal on addictions AU - Kausch, Otto AU - Rugle, Loreen AU - Rowland, Douglas Y AD - Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Otto.Kausch@med.va.gov PY - 2006 SP - 35 EP - 43 VL - 15 IS - 1 SN - 1055-0496, 1055-0496 KW - Index Medicus KW - Child Abuse -- psychology KW - Suicide, Attempted -- psychology KW - Child Abuse -- statistics & numerical data KW - Humans KW - Aged KW - Personality Inventory KW - Child KW - Impulsive Behavior -- epidemiology KW - Comorbidity KW - Cross-Sectional Studies KW - Suicide, Attempted -- statistics & numerical data KW - Risk Factors KW - Impulsive Behavior -- psychology KW - Adult KW - Middle Aged KW - Statistics as Topic KW - Male KW - Female KW - Hospitals, Veterans KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Gambling -- psychology KW - Veterans -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Life Change Events KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Veterans -- psychology KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70726409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Lifetime+histories+of+trauma+among+pathological+gamblers.&rft.au=Kausch%2C+Otto%3BRugle%2C+Loreen%3BRowland%2C+Douglas+Y&rft.aulast=Kausch&rft.aufirst=Otto&rft.date=2006-01-01&rft.volume=15&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-09 N1 - Date created - 2006-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of two versions of the clinical institute withdrawal assessment for alcohol: the CIWA-Ar and CIWA-AD. AN - 70713765; 16449097 AB - Scores from two versions of the Clinical Institute Withdrawal Assessment for Alcohol, the CIWA-Ar and CIWA-AD, were compared in 135 alcohol detoxification episodes. The paired mean score for withdrawal severity was statistically higher with the CIWA-AD (p < 0.001), but the mean difference of 0.45 (95% CI: 0.38-0.53, t = 11.74) is not likely to be clinically significant. The difference in the total score between the two scales was 1 point or less 82.6% of the time, and nearly all (97.7%) of the CIWA-AD scores were within 3 points of the paired CIWA-Ar score (range - 6 to + 6). JF - The American journal on addictions AU - Reoux, Joseph P AU - Oreskovich, Michael R AD - VA Puget Sound Health Care System, Seattle, Washington 98108, USA. joe.reoux@med.va.gov PY - 2006 SP - 85 EP - 93 VL - 15 IS - 1 SN - 1055-0496, 1055-0496 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Washington KW - Prospective Studies KW - Substance Abuse Treatment Centers KW - Reproducibility of Results KW - Patient Admission KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Ethanol -- adverse effects KW - Substance Withdrawal Syndrome -- diagnosis KW - Veterans -- psychology KW - Neurologic Examination KW - Diagnostic and Statistical Manual of Mental Disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70713765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=A+comparison+of+two+versions+of+the+clinical+institute+withdrawal+assessment+for+alcohol%3A+the+CIWA-Ar+and+CIWA-AD.&rft.au=Reoux%2C+Joseph+P%3BOreskovich%2C+Michael+R&rft.aulast=Reoux&rft.aufirst=Joseph&rft.date=2006-01-01&rft.volume=15&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-09 N1 - Date created - 2006-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oral ddAVP for nighttime urinary incontinence in characterized nursing home residents: a pilot study. AN - 70683082; 16413428 AB - To (1) identify abnormalities in arginine vasopressin (AVP, a water-conserving hormone) secretion and release in nursing home (NH) residents with nighttime urinary incontinence (UI); and (2) perform a pilot test of desmopressin acetate (ddAVP, a synthetic analog of the naturally occurring hormone) replacement in these residents. Diagnostic evaluation and open-label treatment trial. Two community nursing homes in a metropolitan area. Male and female NH residents 65 years of age and older with nighttime UI. Characterizations of AVP status followed by a 7-day open-label trial of oral ddAVP (either 0.1 mg or 0.2 mg). Water deprivation test results, AVP levels, voided volumes, number of voids, incontinent episodes, number of nighttime checks found wet (out of 6 total checks per night). All participants had measurable AVP levels of 2.0 pg/mL or higher. Six of 10 individuals had an abnormal water deprivation test. Two of 4 participants on 0.2 mg of ddAVP and 2 of 6 participants on 0.1 mg had a 200 mL or more mean reduction in nighttime urine volume. Both ddAVP dosages yielded a mean reduction of 0.7 fewer nighttime wet checks found wet. One participant in each group developed hyponatremia (1 of 6 on 0.1 mg and 1 of 4 on 0.2 mg). Hyponatremia resolved with discontinuation of the drug. Both 0.1 mg and 0.2 mg of ddAVP given to carefully screened NH residents for 7 days produced a modest average reduction in nighttime urine volume and number of nighttime incontinent episodes that is likely of little clinical importance. The role of ddAVP in this population requires further research. JF - Journal of the American Medical Directors Association AU - Johnson, Theodore M AU - Miller, Myron AU - Tang, Terence AU - Pillion, Dennis J AU - Ouslander, Joseph G AD - The Birmingham/Atlanta VA Geriatric Research, Education, and Clinical Center, Atlanta, GA 30033, USA. Ted.Johnson@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 6 EP - 11 VL - 7 IS - 1 SN - 1525-8610, 1525-8610 KW - Antidiuretic Agents KW - 0 KW - Arginine Vasopressin KW - 113-79-1 KW - Sodium KW - 9NEZ333N27 KW - Deamino Arginine Vasopressin KW - ENR1LLB0FP KW - Index Medicus KW - Administration, Oral KW - Age Factors KW - Urodynamics KW - Diapers, Adult KW - Humans KW - Aged KW - Pilot Projects KW - Water Deprivation KW - Geriatric Assessment KW - Aged, 80 and over KW - Treatment Outcome KW - Sodium -- blood KW - Hyponatremia -- chemically induced KW - Time Factors KW - Female KW - Male KW - Nursing Homes KW - Hyponatremia -- blood KW - Antidiuretic Agents -- adverse effects KW - Arginine Vasopressin -- blood KW - Deamino Arginine Vasopressin -- therapeutic use KW - Enuresis -- metabolism KW - Enuresis -- diagnosis KW - Deamino Arginine Vasopressin -- adverse effects KW - Antidiuretic Agents -- therapeutic use KW - Enuresis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70683082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Directors+Association&rft.atitle=Oral+ddAVP+for+nighttime+urinary+incontinence+in+characterized+nursing+home+residents%3A+a+pilot+study.&rft.au=Johnson%2C+Theodore+M%3BMiller%2C+Myron%3BTang%2C+Terence%3BPillion%2C+Dennis+J%3BOuslander%2C+Joseph+G&rft.aulast=Johnson&rft.aufirst=Theodore&rft.date=2006-01-01&rft.volume=7&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Directors+Association&rft.issn=15258610&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-12 N1 - Date created - 2006-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Co-morbid traumatic brain injury and substance use disorder: childhood predictors and adult correlates. AN - 70671242; 16403699 AB - To examine demographic factors, childhood experiences and behaviour problems and adult psychopathology associated with a history of adult traumatic brain injury (TBI) with unconsciousness in patients with substance use disorders (SUD). Voluntary patients (n = 550) undergoing treatment for SUD were compared for clinical and demographic variables based on report of TBI. Among the 218 (40%) patients reporting TBI, 61% were men. Childhood conduct problems and loss of a parent were strongly associated with adult TBI. Patients with TBI had more severe SUD and higher rates of depressive and anxiety symptoms, somatic concerns, physical trauma, attempted suicide and Antisocial Personality Disorder. Men have a higher rate of TBI than women, but women with SUD have an increased relative risk of TBI compared to women in the general population. Childhood conduct problems and loss of a parent in childhood may predict adult risk-taking behaviour that leads to TBI in patients with SUD. TBI is associated with higher rates of psychopathology in patients with SUD. JF - Brain injury AU - Felde, Anne B AU - Westermeyer, Joseph AU - Thuras, Paul AD - Minneapolis VAMC, MN 55417, USA. Anne.Felde@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 41 EP - 49 VL - 20 IS - 1 SN - 0269-9052, 0269-9052 KW - Index Medicus KW - Humans KW - Aged KW - Antisocial Personality Disorder -- psychology KW - Comorbidity KW - Antisocial Personality Disorder -- complications KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Conduct Disorder -- complications KW - Conduct Disorder -- psychology KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Unconsciousness -- complications KW - Substance-Related Disorders -- complications KW - Substance-Related Disorders -- psychology KW - Brain Injuries -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70671242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+injury&rft.atitle=Co-morbid+traumatic+brain+injury+and+substance+use+disorder%3A+childhood+predictors+and+adult+correlates.&rft.au=Felde%2C+Anne+B%3BWestermeyer%2C+Joseph%3BThuras%2C+Paul&rft.aulast=Felde&rft.aufirst=Anne&rft.date=2006-01-01&rft.volume=20&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Brain+injury&rft.issn=02699052&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-03 N1 - Date created - 2006-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An evidence-based project to improve depression and alcohol use screening. AN - 70211476; 16340695 AB - Using research to improve practice is a high priority. Research shows that routine screening helps identify adults who are at risk for various disorders. Depression and alcohol use screening tools can improve evaluation and treatment. Nurses aimed to improve the screening rates for depression and alcohol use from the existing 50%-80% to 100% with a 1-hour educational program on depression screening and alcohol use disorders screening for 2 clinic areas: primary care and home-based care. Post program evaluation revealed that depression screening and alcohol use disorders screening rates increased to 100%. JF - Journal of nursing care quality AU - Valente, Sharon AU - Nemec, Constance AD - Department of Veterans Affairs, Los Angeles, CA 90049, USA. sharon.valente@med.va.gov PY - 2006 SP - 93 EP - 98 VL - 21 IS - 1 SN - 1057-3631, 1057-3631 KW - Index Medicus KW - Nursing KW - Nursing Methodology Research KW - Attitude of Health Personnel KW - Humans KW - Nursing Education Research KW - Outcome Assessment (Health Care) KW - Benchmarking KW - Home Care Services -- standards KW - Curriculum KW - Health Services Accessibility -- standards KW - Program Development KW - Nurse's Role KW - Program Evaluation KW - Primary Health Care -- standards KW - Alcohol-Related Disorders -- diagnosis KW - Evidence-Based Medicine -- education KW - Mass Screening -- psychology KW - Depressive Disorder -- diagnosis KW - Mass Screening -- standards KW - Education, Nursing, Continuing -- organization & administration KW - Total Quality Management -- organization & administration KW - Evidence-Based Medicine -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70211476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nursing+care+quality&rft.atitle=An+evidence-based+project+to+improve+depression+and+alcohol+use+screening.&rft.au=Valente%2C+Sharon%3BNemec%2C+Constance&rft.aulast=Valente&rft.aufirst=Sharon&rft.date=2006-01-01&rft.volume=21&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+nursing+care+quality&rft.issn=10573631&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-14 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Validation of the primary care alcohol severity measure. AN - 70197397; 16340622 AB - Alcohol-related disorders are common in primary care settings; many primary care physicians are ill-equipped to manage patients with alcohol-related disorders. The objective of this prospective cohort study was to develop and validate a patient-based measure, the Primary Care Alcohol Severity Measure, to determine which primary care patients with alcohol-related disorders would benefit from referral to alcohol treatment services. Four Boston-area Department of Veterans Affairs ambulatory care clinics were chosen as study sites. Two hundred seventy-eight male patients, mean age 55.5 years, 89.9% Caucasian, 42.5% married, all with CAGE Questionnaire scores greater than or equal to 2 and drinking within past year, participated in the study. We developed a multidimensional, 30-item measure that contained 2 subscales that assessed 2 symptom clusters of alcohol-related disorders: Physical and Behavioral. Each subscale's score was higher (more severe) for patients with a current Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised diagnosis of alcohol dependence or abuse: P < .01 for the physical subscale and P < .0001 for the behavioral subscale. Patients with more physical symptoms had poorer physical and mental health status, whereas patients with more behavioral symptoms had poorer mental health status. Scores on the 2 subscales, along with age and history of prior treatment, predicted the use of alcohol treatment services in the following year: c = 0.90 in logistic regression. The Primary Care Alcohol Severity Measure is a valid measure of alcohol severity in primary care patients and predicts the use of alcohol treatment services. It is relatively brief and easy to use, requiring only standard medical history items and patient reports of behavioral symptoms. It may be a useful tool to improve the quality of care for primary care patients with alcohol-related disorders. JF - The Journal of ambulatory care management AU - Mansell, Dorcas AU - Spiro, Avron AU - Lee, Austin AU - Kazis, Lewis AD - University of Alabama at Birmingham School of Medicine and Birmingham VAMC, Birmingham, Tuscaloosa, AL 35404, USA. Dorcas.Mansell@med.va.gov PY - 2006 SP - 87 EP - 97 VL - 29 IS - 1 SN - 0148-9917, 0148-9917 KW - Health administration KW - Veterans KW - United States KW - Outpatients KW - Prospective Studies KW - Aged, 80 and over KW - Humans KW - Cohort Studies KW - Adult KW - Aged KW - Middle Aged KW - Boston -- epidemiology KW - Male KW - Alcoholism -- epidemiology KW - Alcoholism -- classification KW - Surveys and Questionnaires KW - Primary Health Care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70197397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+ambulatory+care+management&rft.atitle=Validation+of+the+primary+care+alcohol+severity+measure.&rft.au=Mansell%2C+Dorcas%3BSpiro%2C+Avron%3BLee%2C+Austin%3BKazis%2C+Lewis&rft.aulast=Mansell&rft.aufirst=Dorcas&rft.date=2006-01-01&rft.volume=29&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+ambulatory+care+management&rft.issn=01489917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The illness burden of alcohol-related disorders among VA patients: the veterans health study. AN - 70193924; 16340620 AB - Little is known about the illness burden associated with alcohol-related disorders (ie, problem drinking, alcohol abuse, and alcohol dependence) among patients in outpatient medical care. The objective of this study was to examine several aspects of illness burden-medical comorbidities, patterns of health services use, and functional status-among Veterans Health Administration (VA) ambulatory care patients with alcohol-related disorders. Male participants (N = 2425) were recruited at 1 of 4 Boston-area VA outpatient clinics. They completed self-report screening measures of current alcohol-related disorders (CAGE score > or =2 with past year alcohol consumption), health behaviors, medical comorbidities, and functional status (SF-36). A medical history interview, which assessed comorbid conditions and use of recent health services, was also administered. Screening criteria for current alcohol-related disorders were satisfied by 12%; however, only 40% of these reported ever receiving treatment specifically for alcohol-related disorders. Patients who screened positive for alcohol-related disorders reported significantly greater limitations in mental health function, longer hospitalizations for medical care in the prior year, and fewer outpatient medical visits in the previous 3 months. Findings suggest considerable illness burden associated with alcohol-related disorders among VA ambulatory care patients. Efforts to increase detection and treatment of alcohol-related disorders may lessen the illness burden and cost of alcohol-related disorders. JF - The Journal of ambulatory care management AU - Mansell, Dorcas AU - Penk, Walter AU - Hankin, Cheryl S AU - Lee, Austin AU - Spiro, Avron AU - Skinner, Katherine M AU - Hsieh, Juling AU - Kazis, Lewis E AD - University of Alabama at Birmingham School of Medicine and Birmingham VAMC, Tuscaloosa, AL 35404, USA. Dorcas.Mansell@med.va.gov PY - 2006 SP - 61 EP - 70 VL - 29 IS - 1 SN - 0148-9917, 0148-9917 KW - Health administration KW - United States KW - Aged, 80 and over KW - United States Department of Veterans Affairs KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Cost of Illness KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70193924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+ambulatory+care+management&rft.atitle=The+illness+burden+of+alcohol-related+disorders+among+VA+patients%3A+the+veterans+health+study.&rft.au=Mansell%2C+Dorcas%3BPenk%2C+Walter%3BHankin%2C+Cheryl+S%3BLee%2C+Austin%3BSpiro%2C+Avron%3BSkinner%2C+Katherine+M%3BHsieh%2C+Juling%3BKazis%2C+Lewis+E&rft.aulast=Mansell&rft.aufirst=Dorcas&rft.date=2006-01-01&rft.volume=29&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+ambulatory+care+management&rft.issn=01489917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adjunctive risperidone treatment and sleep symptoms in combat veterans with chronic PTSD. AN - 69025078; 16845653 AB - Sleep disturbances are core symptoms of posttraumatic stress disorder (PTSD) and are often resistant to treatment. One reason for the recent use of atypical antipsychotics in PTSD appears to be their effects on sleep. Study objectives were (1) to evaluate preliminarily the sleep effects of adjunctive risperidone, and (2) to evaluate the use of sleep diaries versus the more standard retrospective sleep assessments. This was a pilot, open-label, 12-week, flexible-dose trial of adjunctive risperidone in male veterans with a primary diagnosis of chronic, combat-related PTSD, partially responsive to current medications. Diagnostic interviews were administered at baseline, and PTSD ratings were obtained at baseline and at 6 and 12 weeks. Self-report sleep measures, including morning logs, were obtained at baseline and 6 weeks. Seventeen patients completed at least 6 weeks of the trial. Global ratings of sleep disturbance improved. Changes in frequency of awakenings and reductions in trauma-related dreams were only evident via morning log assessments. Nighttime awakening frequency derived from the sleep logs but not from the Pittsburgh Sleep Quality Index (PSQI) decreased significantly. There were no changes in the PSQI nightmare item; however, sleep log data indicated a reduced proportion of traumatic dreams at 6 weeks. Preliminary results suggest that adjunctive risperidone may benefit sleep disturbances associated with chronic PTSD. Prospective logs may be more sensitive to change than are retrospective scales. Published 2006 Wiley-Liss, Inc. JF - Depression and anxiety AU - David, Daniella AU - De Faria, Ludmila AU - Mellman, Thomas A AD - Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL 33125, USA. daniella.david@va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 489 EP - 491 VL - 23 IS - 8 SN - 1091-4269, 1091-4269 KW - Antipsychotic Agents KW - 0 KW - Risperidone KW - L6UH7ZF8HC KW - Index Medicus KW - Drug Therapy, Combination KW - Medical Records KW - Prospective Studies KW - Humans KW - Retrospective Studies KW - Aged KW - Pilot Projects KW - Middle Aged KW - Chronic Disease KW - Male KW - Vietnam KW - Combat Disorders -- psychology KW - Combat Disorders -- drug therapy KW - Dyssomnias -- diagnosis KW - Antipsychotic Agents -- therapeutic use KW - Veterans -- psychology KW - Dyssomnias -- drug therapy KW - Combat Disorders -- diagnosis KW - Risperidone -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Risperidone -- therapeutic use KW - Dyssomnias -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69025078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+anxiety&rft.atitle=Adjunctive+risperidone+treatment+and+sleep+symptoms+in+combat+veterans+with+chronic+PTSD.&rft.au=David%2C+Daniella%3BDe+Faria%2C+Ludmila%3BMellman%2C+Thomas+A&rft.aulast=David&rft.aufirst=Daniella&rft.date=2006-01-01&rft.volume=23&rft.issue=8&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Depression+and+anxiety&rft.issn=10914269&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-14 N1 - Date created - 2006-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bagoas. AN - 68789611; 16939172 JF - The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha AU - Mackowiak, Philip A AD - University of Maryland School of Medicine, 21201, USA. Philip.Mackowiak@med.va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 26 EP - 28 VL - 69 IS - 3 SN - 0031-7179, 0031-7179 KW - Index Medicus KW - Alexander the Great KW - Acute Disease KW - Greece KW - Humans KW - History, Ancient KW - Male KW - Alcoholic Intoxication -- history KW - Fever -- history KW - Famous Persons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68789611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Pharos+of+Alpha+Omega+Alpha-Honor+Medical+Society.+Alpha+Omega+Alpha&rft.atitle=Bagoas.&rft.au=Mackowiak%2C+Philip+A&rft.aulast=Mackowiak&rft.aufirst=Philip&rft.date=2006-01-01&rft.volume=69&rft.issue=3&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=The+Pharos+of+Alpha+Omega+Alpha-Honor+Medical+Society.+Alpha+Omega+Alpha&rft.issn=00317179&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-26 N1 - Date created - 2006-08-30 N1 - Date revised - 2017-01-13 N1 - People - Alexander the Great N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Alexander the Great ER - TY - JOUR T1 - Some effects of multiple sclerosis on speech perception in noise: Preliminary findings. AN - 68649936; 16847775 AB - The present investigation examined speech perception in noise of adults with and without multiple sclerosis (MS). Institute of Electrical and Electronic Engineers (IEEE) sentences were presented at a constant level of 65 dBA L(eq) (equivalent continuous noise level [4 dB exchange rate]) from a loudspeaker located at 0-degree horizontal azimuth and 1.2 m from the study participant. Uncorrelated multitalker babble was presented from four loudspeakers positioned at 45-, 135-, 225-, and 315-degree azimuths and 1.7 m from the study participant. The starting presentation level for the babble was 55 dBA L(eq). The level of the babble was increased systematically in 1 dB steps until the subject obtained 0% key words correct on the IEEE sentences. Results revealed a significant difference in speech perception between the two groups at nine signal-to-noise ratios. Some clinical implications of these results are discussed. JF - Journal of rehabilitation research and development AU - Lewis, M Samantha AU - Lilly, David J AU - Hutter, Michele AU - Bourdette, Dennis N AU - Saunders, Julie AU - Fausti, Stephen A AD - Department of Veterans Affairs (VA) National Center for Rehabilitative Auditory Research, Portland VA Medical Center (VAMC), Portland, OR 97207, USA. Michele.Lewis3@med.va.gov PY - 2006 SP - 91 EP - 98 VL - 43 IS - 1 KW - Index Medicus KW - United States KW - Severity of Illness Index KW - Reference Values KW - Audiometry KW - Humans KW - Prognosis KW - Aged KW - United States Department of Veterans Affairs KW - Adult KW - Case-Control Studies KW - Incidence KW - Middle Aged KW - Female KW - Male KW - Speech Perception KW - Hearing Disorders -- etiology KW - Hearing Disorders -- epidemiology KW - Multiple Sclerosis -- complications KW - Hearing Disorders -- diagnosis KW - Noise KW - Multiple Sclerosis -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68649936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+rehabilitation+research+and+development&rft.atitle=Some+effects+of+multiple+sclerosis+on+speech+perception+in+noise%3A+Preliminary+findings.&rft.au=Lewis%2C+M+Samantha%3BLilly%2C+David+J%3BHutter%2C+Michele%3BBourdette%2C+Dennis+N%3BSaunders%2C+Julie%3BFausti%2C+Stephen+A&rft.aulast=Lewis&rft.aufirst=M&rft.date=2006-01-01&rft.volume=43&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Journal+of+rehabilitation+research+and+development&rft.issn=1938-1352&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2006-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The use of botulinum toxin in physical medicine and rehabilitation. AN - 68401394; 19610549 AB - A review of the history and pharmacology of the botulinum neurotoxins is presented. Established mechanisms of action are discussed as well as preliminary evidence of other potential mechanisms, as related to botulinum toxins' antinociceptive properties. Methods of administration, including reconstitution, dilution, and basic injection techniques/principles are reviewed. Safety concerns are also addressed. Various applications relevant to the field of Physical Medicine & Rehabilitation are reviewed, specifically uses in the management of muscle over activity syndromes such as upper motor neuron-related spasticity, dystonias, and painful syndromes including Myofascial Pain Syndromes and headaches. Relevant literature related to these applications is reviewed and discussed. Botulinum toxin therapeutic efficacy and possible reasons for treatment failure (including development of antibody-mediated resistance) are discussed. JF - Boletin de la Asociacion Medica de Puerto Rico AU - Cuevas-Trisán, Ramón L AU - Cruz-Jiménez, Maricarmen AD - Physical Medicine & Rehabilitation Service, West Palm Beach Veterans Affairs Medical Center, FL 33410-6400, USA. ramon.cuevas-trisan@med.va.gov PY - 2006 SP - 42 EP - 55 VL - 98 IS - 1 SN - 0004-4849, 0004-4849 KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Index Medicus KW - Myofascial Pain Syndromes -- rehabilitation KW - Headache -- rehabilitation KW - Muscle Spasticity -- drug therapy KW - Rehabilitation -- methods KW - Physical Therapy Modalities KW - Myofascial Pain Syndromes -- drug therapy KW - Humans KW - Dystonia -- rehabilitation KW - Headache -- drug therapy KW - Muscle Spasticity -- rehabilitation KW - Dystonia -- drug therapy KW - Botulinum Toxins -- administration & dosage KW - Botulinum Toxins -- therapeutic use KW - Botulinum Toxins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68401394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Boletin+de+la+Asociacion+Medica+de+Puerto+Rico&rft.atitle=The+use+of+botulinum+toxin+in+physical+medicine+and+rehabilitation.&rft.au=Cuevas-Tris%C3%A1n%2C+Ram%C3%B3n+L%3BCruz-Jim%C3%A9nez%2C+Maricarmen&rft.aulast=Cuevas-Tris%C3%A1n&rft.aufirst=Ram%C3%B3n&rft.date=2006-01-01&rft.volume=98&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Boletin+de+la+Asociacion+Medica+de+Puerto+Rico&rft.issn=00044849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-12 N1 - Date created - 2009-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Megestrol acetate in cachexia and anorexia. AN - 68353823; 17722275 AB - The aim is to review major clinical trials that have used megestrol acetate (MA) in the treatment of cachexia across several disease states. A review of general usage and potential side-effects are discussed. A theory that the newly approved nanocrystal formation of MA can better deliver this potent medication for treatment will also be reviewed. JF - International journal of nanomedicine AU - Yeh, Shing-Shing AU - Schuster, Michael W AD - Northport VAMC, Geriatric division, Northport, NY 11768, USA. shingshing.yeh@med.va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 411 EP - 416 VL - 1 IS - 4 SN - 1176-9114, 1176-9114 KW - Drug Carriers KW - 0 KW - Megestrol Acetate KW - TJ2M0FR8ES KW - Index Medicus KW - Humans KW - Drug Carriers -- chemistry KW - Nanoparticles -- chemistry KW - Megestrol Acetate -- therapeutic use KW - Cachexia -- drug therapy KW - Anorexia -- drug therapy KW - Megestrol Acetate -- adverse effects KW - Clinical Trials as Topic -- trends KW - Megestrol Acetate -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68353823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+nanomedicine&rft.atitle=Megestrol+acetate+in+cachexia+and+anorexia.&rft.au=Yeh%2C+Shing-Shing%3BSchuster%2C+Michael+W&rft.aulast=Yeh&rft.aufirst=Shing-Shing&rft.date=2006-01-01&rft.volume=1&rft.issue=4&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=International+journal+of+nanomedicine&rft.issn=11769114&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nutrition. 1999 Apr;15(4):294-8 [10319362] JAMA. 1999 Jun 2;281(21):2013-9 [10359390] J Clin Oncol. 1999 Oct;17(10):3299-306 [10506633] JAMA. 1987 Mar 6;257(9):1195-8 [3806918] J Steroid Biochem. 1987 Mar;26(3):313-9 [2953940] Ann Intern Med. 1988 Nov 15;109(10):840-1 [3190032] Semin Oncol. 1991 Feb;18(1 Suppl 2):35-42 [1992535] Drugs. 1992 Apr;43(4):499-506 [1377116] Am J Clin Oncol. 1992 Oct;15(5):436-40 [1524045] Oncology. 1992;49 Suppl 2:46-9 [1461628] Mayo Clin Proc. 1992 Dec;67(12):1160-2 [1469926] J Clin Oncol. 1993 Apr;11(4):762-7 [8478668] J Acquir Immune Defic Syndr. 1994 Jun;7(6):580-6 [8176641] Ann Intern Med. 1994 Sep 15;121(6):400-8 [8053613] JAMA. 1994 Nov 23-30;272(20):1601-6 [7966871] Cochrane Database Syst Rev. 2005;(2):CD004310 [15846706] J Am Geriatr Soc. 2005 Jun;53(6):970-5 [15935019] BioDrugs. 2005;19(3):179-87 [15984902] J Am Geriatr Soc. 1995 Apr;43(4):329-37 [7706619] J Periodontol. 1995 Apr;66(4):279-84 [7782982] J Gerontol A Biol Sci Med Sci. 1995 Nov;50 Spec No:101-6 [7493200] J Natl Cancer Inst Monogr. 1996;(20):79-80 [8750472] Oncology (Williston Park). 1996 Jul;10(7):1049-56; discussion 1062-4, 1067-8 [8837121] Steroids. 1996 Mar;61(3):133-7 [8852830] Am J Clin Nutr. 1997 Mar;65(3):717-23 [9062520] Proc Nutr Soc. 1997 Mar;56(1A):25-40 [9168518] Arch Intern Med. 1997 Aug 11-25;157(15):1651-6 [9250225] Adv Exp Med Biol. 1997;411:83-9 [9269414] Support Care Cancer. 1997 Sep;5(5):422-3 [9322357] Clin Geriatr Med. 1997 Nov;13(4):717-35 [9354751] J Reprod Fertil Suppl. 1997;51:345-54 [9404305] J Am Geriatr Soc. 2000 May;48(5):485-92 [10811540] Eur J Clin Nutr. 2000 Jun;54 Suppl 3:S64-9 [11041077] J Gerontol A Biol Sci Med Sci. 2001 Jan;56(1):M48-54 [11193233] J Nutr Health Aging. 2000;4(4):246-51 [11115810] Gynecol Endocrinol. 2001 Oct;15(5):341-8 [11727356] Circulation. 2001 Dec 4;104(23):2826-31 [11733402] J Clin Oncol. 2002 Jan 15;20(2):567-73 [11786587] Clin Diagn Lab Immunol. 2002 May;9(3):583-7 [11986264] J Clin Endocrinol Metab. 2002 May;87(5):2100-6 [11994348] Pediatr Pulmonol. 2002 Nov;34(5):381-3 [12357484] Chest. 2003 Jan;123(1):309-10; author reply 310 [12527643] J Pediatr Hematol Oncol. 2003 May;25(5):414-7 [12759631] Neoplasma. 2003;50(3):227-33 [12937858] J Am Med Dir Assoc. 2003 Sep-Oct;4(5):255-6 [12959653] J Am Med Dir Assoc. 2004 Jan-Feb;5(1):24-30 [14706125] J Am Med Dir Assoc. 2004 Jan-Feb;5(1):65-6; author reply 66-7 [14726802] Clin Infect Dis. 2004 Mar 15;38(6):895-902 [14999637] J Pain Symptom Manage. 2004 Apr;27(4):360-9 [15050664] J Clin Oncol. 2004 Jun 15;22(12):2469-76 [15197210] J Am Geriatr Soc. 2004 Oct;52(10):1708-12 [15450049] J Pharm Pharmacol. 2004 Oct;56(10):1233-41 [15482637] Urol Int. 1979;34(5):330-8 [494436] Biochem Pharmacol. 1983 May 1;32(9):1511-8 [6222739] Cancer Chemother Pharmacol. 1984;12(2):83-6 [6321047] Cancer Chemother Pharmacol. 1985;15(2):167-70 [3160504] Oncology. 1994 Oct;51 Suppl 1:19-24 [7970504] Oncology. 1994 Oct;51 Suppl 1:2-7 [7970505] Am J Physiol. 1998 Feb;274(2 Pt 2):R420-7 [9486300] Br J Nutr. 1998 Jan;79(1):107-13 [9505809] Am J Med. 1998 Jan;104(1):40-7 [9528718] Semin Oncol. 1998 Apr;25(2 Suppl 6):45-52 [9625383] Semin Oncol. 1998 Apr;25(2 Suppl 6):58-61 [9625385] J Neuroendocrinol. 1998 Sep;10(9):719-27 [9744490] Clin Immunol Immunopathol. 1998 Dec;89(3):231-9 [9837693] Crit Rev Oncog. 1998;9(2):99-106 [9973244] JAMA. 1999 Apr 14;281(14):1282-90 [10208143] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Outpatient treatment engagement and abstinence rates following inpatient opioid detoxification. AN - 68121873; 17088223 AB - Many patients with chronic opioid dependence are referred to drug-free outpatient treatment following inpatient detoxification even though successful outpatient treatment engagement and abstinence from opioids occur only in a minority of cases. This retrospective cohort analysis of medical records documents the post-discharge outcome in a treatment setting that maximizes the support during transition to abstinence-oriented outpatient care, with comprehensive social, medical and mental health services, including the availability of naltrexone. Participants were male veterans (N = 112) admitted at an urban VA medical center. Most patients (78%) successfully completed acute detoxification, 49% initiated naltrexone, and 76% accepted a VA aftercare plan. At 90-day follow-up, only 22% remained in aftercare, and < 3% had toxicology-verified abstinence from opioids. At one-year follow-up, 1 out of 5 had been readmitted for detoxification and 4.5% had died. Most patients successfully detoxified from opioids, but very few remained engaged and stabilized in abstinence-oriented outpatient treatment. JF - Journal of addictive diseases AU - Davison, John W AU - Sweeney, Marie L AU - Bush, Kristen R AU - Davis Correale, Tania M AU - Calsyn, Donald A AU - Reoux, Joseph P AU - Sloan, Kevin L AU - Kivlahan, Daniel R AD - Va Puget Sound Health Care System, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seatte, WA 98195, USA. John.Davison@va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 27 EP - 35 VL - 25 IS - 4 SN - 1055-0887, 1055-0887 KW - Narcotic Antagonists KW - 0 KW - Naltrexone KW - 5S6W795CQM KW - Index Medicus KW - Veterans KW - Aftercare -- statistics & numerical data KW - Psychotherapy, Group KW - Length of Stay -- statistics & numerical data KW - Humans KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Hospitalization -- statistics & numerical data KW - Time Factors KW - Male KW - Patient Compliance -- statistics & numerical data KW - Opioid-Related Disorders -- epidemiology KW - Inactivation, Metabolic KW - Narcotic Antagonists -- therapeutic use KW - Ambulatory Care -- statistics & numerical data KW - Opioid-Related Disorders -- rehabilitation KW - Naltrexone -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68121873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+addictive+diseases&rft.atitle=Outpatient+treatment+engagement+and+abstinence+rates+following+inpatient+opioid+detoxification.&rft.au=Davison%2C+John+W%3BSweeney%2C+Marie+L%3BBush%2C+Kristen+R%3BDavis+Correale%2C+Tania+M%3BCalsyn%2C+Donald+A%3BReoux%2C+Joseph+P%3BSloan%2C+Kevin+L%3BKivlahan%2C+Daniel+R&rft.aulast=Davison&rft.aufirst=John&rft.date=2006-01-01&rft.volume=25&rft.issue=4&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Journal+of+addictive+diseases&rft.issn=10550887&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-21 N1 - Date created - 2006-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational hand infections. AN - 67918970; 16647654 AB - Prompt diagnosis and treatment of hand and upper extremity infections is imperative because they have the potential to be life threatening and pose a risk of functional impairment. Serious infections may result in prolonged hospitalization and resultant loss of productivity. The mainstay of treatment continues to be antibiotic therapy, heat, elevation, adequate surgical drainage, and débridement. Prompt specialty consultation should be obtained in cases in which there is a doubt about the diagnosis or when there is failure to improve in the face of seemingly appropriate treatment. JF - Clinics in occupational and environmental medicine AU - Gaar, Earl AD - Department of Surgery, University of Louisville School of Medicine, 529 South Jackson Street, Louisville, KY 40202, USA. earl.gaar@med.va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 369 EP - 80, viii VL - 5 IS - 2 SN - 1526-0046, 1526-0046 KW - Anti-Infective Agents KW - 0 KW - Index Medicus KW - Occupational Health KW - Tenosynovitis -- diagnosis KW - Drainage KW - Humans KW - Bites and Stings -- complications KW - Paronychia -- diagnosis KW - Anti-Infective Agents -- therapeutic use KW - Treatment Outcome KW - Suppuration KW - Debridement KW - Cellulitis -- diagnosis KW - Infection Control KW - Arthritis, Infectious -- diagnosis KW - Early Diagnosis KW - Hand Injuries -- complications KW - Occupational Medicine KW - Occupational Diseases -- diagnosis KW - Hand Dermatoses -- epidemiology KW - Skin Diseases, Infectious -- etiology KW - Skin Diseases, Infectious -- epidemiology KW - Hand Dermatoses -- diagnosis KW - Skin Diseases, Infectious -- diagnosis KW - Occupational Diseases -- etiology KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- therapy KW - Hand Dermatoses -- etiology KW - Skin Diseases, Infectious -- therapy KW - Hand Dermatoses -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67918970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+occupational+and+environmental+medicine&rft.atitle=Occupational+hand+infections.&rft.au=Gaar%2C+Earl&rft.aulast=Gaar&rft.aufirst=Earl&rft.date=2006-01-01&rft.volume=5&rft.issue=2&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Clinics+in+occupational+and+environmental+medicine&rft.issn=15260046&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-30 N1 - Date created - 2006-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Guillain-Barré syndrome as a cause of reversible cardiomyopathy. AN - 67812778; 16572872 AB - Although autonomic dysfunction is a common manifestation of Guillain-Barré syndrome, cardiovascular involvement in this setting has rarely been reported in the literature. We describe a case of reversible left ventricular systolic dysfunction in a 60-year-old man with Guillain-Barré syndrome. Our patient had no history or signs of cardiac dysfunction on initial presentation. During the clinical manifestation of his autonomic dysfunction, he developed electrocardiographic changes accompanied by mildly elevated cardiac enzymes and severe left ventricular systolic dysfunction and segmental wall motion abnormality, which coincided with elevated urinary catecholamine and vanilmandelic acid levels. These abnormalities, and his symptoms, resolved rapidly once the acute episode was over. We believe the reversible left ventricular dysfunction was due to the toxic effect of increased catecholamines and to the transiently damaged sympathetic nerve endings in the myocardium, presumably a consequence of Guillain-Barré syndrome. We recommend that echocardiography be performed in patients with clinical signs of autonomic dysfunction, especially if they are associated with abnormal electrocardiographic findings, cardiac enzyme elevation, or hemodynamic instability, so that appropriate medical therapy can be instituted in a timely manner. JF - Texas Heart Institute journal AU - Finkelstein, Jason S AU - Melek, Bekir H AD - Department of Medicine, Section of Cardiology, Veterans Administration Medical Center and Tulane University School of Medicine, New Orleans, Louisiana 70112, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 57 EP - 59 VL - 33 IS - 1 SN - 0730-2347, 0730-2347 KW - Index Medicus KW - Humans KW - Middle Aged KW - Male KW - Ventricular Dysfunction, Left -- etiology KW - Guillain-Barre Syndrome -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67812778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Texas+Heart+Institute+journal&rft.atitle=Guillain-Barr%C3%A9+syndrome+as+a+cause+of+reversible+cardiomyopathy.&rft.au=Finkelstein%2C+Jason+S%3BMelek%2C+Bekir+H&rft.aulast=Finkelstein&rft.aufirst=Jason&rft.date=2006-01-01&rft.volume=33&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Texas+Heart+Institute+journal&rft.issn=07302347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-30 N1 - Date created - 2006-03-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cleve Clin J Med. 2007 Feb;74 Suppl 1:S8-16 [17455536] Neurology. 2000 Feb 8;54(3):759-62 [10680822] Acta Neurol Scand. 2002 Jan;105(1):44-50 [11903108] Jpn Circ J. 1995 Apr;59(4):236-40 [7658618] Intensive Care Med. 1980;6(1):3-6 [7356703] Jpn J Med. 1985 Feb;24(1):24-9 [3999461] Acta Neurol Scand. 1987 Feb;75(2):101-5 [3577674] No To Shinkei. 2003 Jun;55(6):517-20 [12884804] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug injury in the upper gastrointestinal tract: nonsteroidal anti-inflammatory drugs. AN - 67762735; 16546025 AB - It is well established that nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin confer significant morbidity and mortality. The widespread use of these drugs has increased the absolute numbers of cases of NSAID- or aspirin-related upper gastrointestinal complications. Emerging data indicate that antidepressants, such as selective serotonin reuptake inhibitors and tricyclic antidepressants, may also increase risk for gastrointestinal bleeding. Multiple factors have been identified that increase risk for NSAID- and aspirin-related upper gastrointestinal complications. The highest risks are related to age (>60 years) and prior complicated peptic ulcer; additional risk factors include use of multiple NSAIDs and high doses of NSAIDS. Recent studies have demonstrated enhanced healing and prevention of NSAID- and aspirin-related gastrointestinal lesions with proton pump inhibitors. JF - Gastrointestinal endoscopy clinics of North America AU - Go, Mae F AD - Veterans Administration Salt Lake City Health Care System, UT 84106, USA. mae.go@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 83 EP - 97 VL - 16 IS - 1 SN - 1052-5157, 1052-5157 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Proton Pump Inhibitors KW - Serotonin Uptake Inhibitors KW - Omeprazole KW - KG60484QX9 KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Omeprazole -- pharmacology KW - Animals KW - Sex Factors KW - Aspirin -- adverse effects KW - Risk Factors KW - Humans KW - Middle Aged KW - Serotonin Uptake Inhibitors -- pharmacology KW - Peptic Ulcer -- epidemiology KW - Female KW - Gastrointestinal Tract -- drug effects KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67762735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastrointestinal+endoscopy+clinics+of+North+America&rft.atitle=Drug+injury+in+the+upper+gastrointestinal+tract%3A+nonsteroidal+anti-inflammatory+drugs.&rft.au=Go%2C+Mae+F&rft.aulast=Go&rft.aufirst=Mae&rft.date=2006-01-01&rft.volume=16&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Gastrointestinal+endoscopy+clinics+of+North+America&rft.issn=10525157&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-23 N1 - Date created - 2006-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of noise on the morphology of the intestinal mucosa in laboratory rats. AN - 67755659; 16539340 AB - To determine whether noise-induced stress disrupts the intestinal mucosa of laboratory rats, one group of 8 rats ("noise" rats) was subjected to 15 min of white noise (90 dB) daily for 3 wk. Another group ("quiet"rats) was housed for 3 wk in an acoustically similar room but with no additional noise. A 3rd group ("recovery" rats) was housed in the noise room for 3 wk and then in the quiet room for a further 3 wk. The ilea were fixed for microscopy. Villi adjacent to Peyer patches showed significantly more degranulated mast cells (mean+/-standard error of the mean, 3.95+/-0.80 versus 0.35+/-0.29, respectively) and eosinophils (mean+/-standard error of the mean, 9.46+/-0.44 versus 4.58+/-0.38) per villus section in noise rats than in quiet rats. Similar results were obtained with rooms reversed, to account for any differences in room characteristics. The mean width of villus laminar propria was significantly greater in noise rats than quiet rats, suggesting edema. In addition, mucosal epithelial cells of noise rats were often separated, sometimes detaching from the basement membrane, whereas those of quiet rats were intact. Behaviorally, noise rats exhibited significantly more grooming and rearing than quiet rats. Compared with noise rats, recovery rats showed no reduction in mast cell degranulation or mean width of villus lamina propria, but there were increased numbers of secreting goblet cells in villi adjacent to Peyer patches and some recovery of epithelial integrity. JF - Journal of the American Association for Laboratory Animal Science : JAALAS AU - Baldwin, Ann L AU - Primeau, Richard L AU - Johnson, William E AD - Department of Physiology, University of Arizona and Veterans Administration Medical Center, Tucson, AZ, USA. abaldwin@u.arizona.edu Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 74 EP - 82 VL - 45 IS - 1 SN - 1559-6109, 1559-6109 KW - Index Medicus KW - Animals KW - Rats, Sprague-Dawley KW - Mast Cells -- pathology KW - Animal Welfare KW - Feeding Behavior KW - Mast Cells -- ultrastructure KW - Male KW - Behavior, Animal KW - Laboratory Animal Science KW - Intestinal Mucosa -- ultrastructure KW - Rats -- psychology KW - Noise KW - Stress, Psychological -- pathology KW - Intestinal Mucosa -- pathology KW - Rats -- anatomy & histology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67755659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Association+for+Laboratory+Animal+Science+%3A+JAALAS&rft.atitle=Effect+of+noise+on+the+morphology+of+the+intestinal+mucosa+in+laboratory+rats.&rft.au=Baldwin%2C+Ann+L%3BPrimeau%2C+Richard+L%3BJohnson%2C+William+E&rft.aulast=Baldwin&rft.aufirst=Ann&rft.date=2006-01-01&rft.volume=45&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Association+for+Laboratory+Animal+Science+%3A+JAALAS&rft.issn=15596109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-24 N1 - Date created - 2006-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Increasing survival with HIV: impact on nursing care. AN - 67633963; 16462404 AB - The introduction of highly active antiretroviral therapy (HAART) has transformed human immunodeficiency virus (HIV) infection from a rapidly progressive catastrophic illness to a chronic condition. Individuals with HIV are living longer and developing conditions usually associated with aging, as well as complications from pre-existing or subsequently acquired conditions. In addition, toxicities associated with HAART may precipitate or exacerbate comorbid conditions. As opportunistic infections account for fewer admission and lower mortality rates, new patterns of illness are emerging. Complex interactions among multiple, sometimes overlapping conditions require focused yet comprehensive attention in care and management. Nurses will encounter HIV-infected patients in an increasing range of care settings, and an understanding of the range and interaction of potential comorbidities and their treatments with HIV and its treatment will be required to provide safe and effective care. JF - AACN clinical issues AU - Halloran, James AD - Department of Veterans Affairs, Public Health Strategic Healthcare Group, Center for Quality Management in Public Health, San Antonio, USA. james.halloran@va.gov PY - 2006 SP - 8 EP - 17 VL - 17 IS - 1 SN - 1079-0713, 1079-0713 KW - Anti-HIV Agents KW - 0 KW - Nursing KW - Health Services Needs and Demand KW - Drug Interactions KW - Humans KW - Aging KW - Disease Progression KW - Patient Care Planning KW - Safety Management KW - Comorbidity KW - Longevity KW - Risk Assessment KW - Patient Education as Topic KW - Survival Rate KW - Patient-Centered Care -- organization & administration KW - Nursing Assessment KW - Drug Monitoring -- nursing KW - HIV-1 -- growth & development KW - Chronic Disease KW - HIV-1 -- drug effects KW - Continuity of Patient Care KW - HIV Infections -- virology KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- therapy KW - Antiretroviral Therapy, Highly Active -- nursing KW - Anti-HIV Agents -- adverse effects KW - Nurse's Role KW - HIV Infections -- mortality KW - Anti-HIV Agents -- classification KW - HIV Infections -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67633963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AACN+clinical+issues&rft.atitle=Increasing+survival+with+HIV%3A+impact+on+nursing+care.&rft.au=Halloran%2C+James&rft.aulast=Halloran&rft.aufirst=James&rft.date=2006-01-01&rft.volume=17&rft.issue=1&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=AACN+clinical+issues&rft.issn=10790713&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-20 N1 - Date created - 2006-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recent sexual abuse, physical abuse, and suicide attempts among male veterans seeking psychiatric treatment. AN - 67613800; 16399970 AB - This study examined the rates of sexual and physical abuse and suicide attempts among male and female patients and focused on the associations between sexual and physical abuse and recent suicide attempts among men. Data were examined for a cohort of patients aged 19 years and older who were seeking treatment for substance use disorders, other psychiatric disorders, or both from the Department of Veterans Affairs (VA) between July 1997 and September 1997. Almost all the patients in the sample (more than 99 percent) had a substance use disorder. Patients were interviewed with the Addiction Severity Index about lifetime and recent (past 30 days) sexual and physical abuse and recent suicide attempts. Because of the low prevalence of suicide attempts in the past 30 days and limited representation of female patients in this sample, the data for female patients were used only to conduct descriptive analyses to compare the prevalence of sexual and physical abuse and suicide attempts between genders. The sample comprised 34,245 patients (33,236 males and 1,009 females). Compared with male patients, female patients were ten times as likely to have been sexually abused in the past 30 days and four times as likely to have been physically abused. Among male patients, bivariate analyses showed that those who had been recently sexually or physically abused were more likely than those who had not experienced such abuse to have attempted suicide recently (odds ratios of 4.8 and 3.0, respectively). After controlling for demographic and diagnostic factors, multivariate logistic regression analyses indicated that recent sexual abuse, recent physical abuse, and lifetime sexual abuse were significantly associated with a higher likelihood of a recent suicide attempt among male patients. Female patients were more likely than their male counterparts to experience sexual and physical abuse. Recent and lifetime history of sexual abuse and recent physical abuse were independent risk factors for recent suicide attempts among men who were seeking treatment. The results suggest that clinicians who identify suicide attempts and suicidal tendencies among male patients should routinely assess for sexual or physical abuse. JF - Psychiatric services (Washington, D.C.) AU - Tiet, Quyen Q AU - Finney, John W AU - Moos, Rudolf H AD - Center for Health Care Evaluation, Department of Veterans Affairs Palo Alto Health Care System, Menlo Park, California 94025, USA. quyen.tiet@va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 107 EP - 113 VL - 57 IS - 1 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - Severity of Illness Index KW - Demography KW - Humans KW - Surveys and Questionnaires KW - Middle Aged KW - United States -- epidemiology KW - Time Factors KW - Sex Distribution KW - Male KW - Female KW - Prevalence KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Violence -- statistics & numerical data KW - Stress Disorders, Post-Traumatic -- therapy KW - Suicide, Attempted -- psychology KW - Veterans -- psychology KW - Mental Health Services -- utilization KW - Substance-Related Disorders -- diagnosis KW - Substance-Related Disorders -- therapy KW - Sex Offenses -- psychology KW - Sex Offenses -- statistics & numerical data KW - Veterans -- statistics & numerical data KW - Patient Acceptance of Health Care KW - Suicide, Attempted -- statistics & numerical data KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Violence -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67613800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Recent+sexual+abuse%2C+physical+abuse%2C+and+suicide+attempts+among+male+veterans+seeking+psychiatric+treatment.&rft.au=Tiet%2C+Quyen+Q%3BFinney%2C+John+W%3BMoos%2C+Rudolf+H&rft.aulast=Tiet&rft.aufirst=Quyen&rft.date=2006-01-01&rft.volume=57&rft.issue=1&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-15 N1 - Date created - 2006-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quality of care for substance use disorders in patients with serious mental illness. AN - 67590697; 16377454 AB - We assessed the quality of care for substance use disorders (SUDs) among 8,083 patients diagnosed with serious mental illness from the VA mid-Atlantic region. Using data from the National Patient Care Database (2001-2002), we assessed the percentage of patients receiving a diagnosis of SUD, percentage beginning SUD treatment 14 days or earlier after diagnosis, and percentage receiving continued SUD care 30 days or less. Overall, 1,559 (19.3%) were diagnosed with an SUD. Of the 1,559, 966 (62.0%) initiated treatment and 847 (54.3%) received continued care. Although patients diagnosed with bipolar disorder were more likely to receive a diagnosis of SUD than those diagnosed with schizophrenia or schizoaffective disorder (22.7%, 18.9%, and 17.7%, respectively; chi(2) = 26.02, df = 2, p < .001), they were less likely to initiate (49.1%, 70.7%, and 68.6%, respectively; chi(2) = 59.29, df = 2, p < .001) or continue treatment (39.9%, 63.2%, and 62.2%, respectively; chi(2) = 72.25, df = 2, p <. 001). Greater efforts are needed to diagnose and treat SUDs in patients with serious mental illness, particularly for those with bipolar disorder. JF - Journal of substance abuse treatment AU - Kilbourne, Amy M AU - Salloum, Ihsan AU - Dausey, David AU - Cornelius, Jack R AU - Conigliaro, Joseph AU - Xu, Xiangyan AU - Pincus, Harold Alan AD - VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA. amy.kilbourne@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 73 EP - 77 VL - 30 IS - 1 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Severity of Illness Index KW - Humans KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - Aged KW - Middle Aged KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - Quality of Health Care -- standards KW - Mental Disorders -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67590697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Quality+of+care+for+substance+use+disorders+in+patients+with+serious+mental+illness.&rft.au=Kilbourne%2C+Amy+M%3BSalloum%2C+Ihsan%3BDausey%2C+David%3BCornelius%2C+Jack+R%3BConigliaro%2C+Joseph%3BXu%2C+Xiangyan%3BPincus%2C+Harold+Alan&rft.aulast=Kilbourne&rft.aufirst=Amy&rft.date=2006-01-01&rft.volume=30&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2005-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic multisymptom illness complex in Gulf War I veterans 10 years later. AN - 67585910; 16293719 AB - Prior research has demonstrated that shortly after the 1991 Gulf War (Gulf War I), chronic multisymptom illness (CMI) was more common among deployed veterans than among nondeployed veterans. The aims of the current study were to determine the prevalence of CMI among deployed and nondeployed veterans 10 years after Gulf War I, compare the distribution of comorbid conditions, and identify prewar factors associated with CMI. Cross-sectional data collected from 1,061 deployed veterans and 1,128 nondeployed veterans examined between 1999 and 2001 were analyzed. CMI prevalence was 28.9% among deployed veterans and 15.8% among nondeployed veterans (odds ratio = 2.16, 95% confidence interval: 1.61, 2.90). Deployed and nondeployed veterans with CMI had similarly poorer quality-of-life measures and higher prevalences of symptom-based medical conditions, metabolic syndrome, and psychiatric disorders. Diagnoses of prewar anxiety disorders (not related to post-traumatic stress disorder) and depression were associated with CMI among both deployed and nondeployed veterans. Nicotine dependence and veteran-reported physician-diagnosed infectious mononucleosis were associated with CMI among deployed veterans, and migraine headaches and gastritis were associated with CMI among nondeployed veterans. CMI continues to be substantially more prevalent among deployed veterans than among nondeployed veterans 10 years after Gulf War I, but it manifests similarly in both groups. It is likely to be a common, persistent problem among veterans returning from the current Gulf War. JF - American journal of epidemiology AU - Blanchard, Melvin S AU - Eisen, Seth A AU - Alpern, Renee AU - Karlinsky, Joel AU - Toomey, Rosemary AU - Reda, Domenic J AU - Murphy, Frances M AU - Jackson, Leila W AU - Kang, Han K AD - Medical and Research Services, St. Louis Veterans Affairs Medical Center, St. Louis, MO 63106, USA. melvin.blanchard@med.va.gov Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - 66 EP - 75 VL - 163 IS - 1 SN - 0002-9262, 0002-9262 KW - Index Medicus KW - Humans KW - Quality of Life KW - Comorbidity KW - Risk Assessment KW - Cross-Sectional Studies KW - Risk Factors KW - Adult KW - Chronic Disease KW - Middle Aged KW - United States -- epidemiology KW - Time Factors KW - Female KW - Male KW - Prevalence KW - Sickness Impact Profile KW - Veterans -- statistics & numerical data KW - Gulf War KW - Persian Gulf Syndrome -- epidemiology KW - Military Personnel -- statistics & numerical data KW - Persian Gulf Syndrome -- physiopathology KW - Military Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67585910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Chronic+multisymptom+illness+complex+in+Gulf+War+I+veterans+10+years+later.&rft.au=Blanchard%2C+Melvin+S%3BEisen%2C+Seth+A%3BAlpern%2C+Renee%3BKarlinsky%2C+Joel%3BToomey%2C+Rosemary%3BReda%2C+Domenic+J%3BMurphy%2C+Frances+M%3BJackson%2C+Leila+W%3BKang%2C+Han+K&rft.aulast=Blanchard&rft.aufirst=Melvin&rft.date=2006-01-01&rft.volume=163&rft.issue=1&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-16 N1 - Date created - 2005-12-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Epidemiol. 2006 Oct 1;164(7):708-9; author reply 709-10 [16943267] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Pharmacological and Psychological Treatment of Personality Disorders -- From Neurobiology to Treatment Strategies AN - 61413907; 200703385 AB - A dimensional approach to the study of personality disorders proposes that abnormalities in cognitive control, affective instability, impulsivity/aggression & anxiety, are biologically mediated & range from Axis I disorders to more chronic, milder disturbances of personality. This approach provides a framework for investigating the neurobiological underpinnings of personality disorders & possible therapeutic interventions. The interplay between biological temperament & environmental adversity contribute to personality dysfunction & this idea is reflected in treatment approaches such as dialectical behavioral therapy. The current neurobiology & specific treatments, both pharmacological & psychosocial, are reviewed. Connections between the biological underpinnings & treatment strategies are presented. Despite the numerous limitations in the treatment literature, therapeutic improvement is possible for individuals with personality disorders. Tables, References. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Family Psychotherapy AU - Goodman, Marianne AU - Vail, Lucia AU - West, Sara AU - New, Antonia AU - Siever, Larry AD - Mount Sinai Mood & Personality Disorder Research Program, Bronx VAMC, NY marianne.goodman@med.va.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 53 EP - 81 PB - Haworth Press, Binghamton NY VL - 17 IS - 3-4 SN - 0897-5353, 0897-5353 KW - Personality disorder, neurobiology, treatment, pharmacology, psychotherapy, dialectical, behavioral therapy KW - Biological Factors KW - Behavior Modification KW - Environmental Factors KW - Treatment Methods KW - Personality Disorders KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61413907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Psychotherapy&rft.atitle=The+Pharmacological+and+Psychological+Treatment+of+Personality+Disorders+--+From+Neurobiology+to+Treatment+Strategies&rft.au=Goodman%2C+Marianne%3BVail%2C+Lucia%3BWest%2C+Sara%3BNew%2C+Antonia%3BSiever%2C+Larry&rft.aulast=Goodman&rft.aufirst=Marianne&rft.date=2006-01-01&rft.volume=17&rft.issue=3-4&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Psychotherapy&rft.issn=08975353&rft_id=info:doi/10.1300%2FJ085v17n03_04 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-08-01 N1 - Number of references - 122 N1 - Last updated - 2016-09-28 N1 - CODEN - JFAPEF N1 - SubjectsTermNotLitGenreText - Personality Disorders; Biological Factors; Environmental Factors; Treatment Methods; Behavior Modification DO - http://dx.doi.org/10.1300/J085v17n03_04 ER - TY - JOUR T1 - Patients' and Healthcare Providers' Understandings of Life-Sustaining Treatment: Are Perceptions of Goals Shared or Divergent? AN - 61350560; 200604766 AB - In this cross-sectional qualitative study, researchers performed in-depth, semistructured interviews with 30 pairs of patients & their primary care providers in an outpatient clinic of a large, urban Veterans Affairs (VA) medical center in the United States. During audiotaped interviews to assess their understanding of advance directive concepts, participants were asked what "life-sustaining treatment" means to them & why they think of it in the way they do. The findings indicate that patients & providers in the United States tend to view & discuss life-sustaining treatment in terms of four goals for end-of-life care: (1) extending the length of life, (2) improving the quality of life, (3) maintaining or improving specific biological functions, & (4) assisting the body for a temporary period of time. Patients thought providers were more concerned with extending the length of life than with quality-based outcomes, & patients often discussed life-sustaining treatment as acceptable means for short-term but not long-term use. Many providers indicated that they struggle with conflicting quality-based & physiologic care goals. The findings highlight the importance of eliciting patient preferences not only for specific types of treatment, such as cardiopulmonary resuscitation, but also for end-of-life care goals or desired health-related outcomes, such as maximizing the quantity of life. The findings also suggest that advance directives & patient-provider discussions that focus on acceptable health states & valued life activities may be better suited to patients' end-of-life care goals than those that focus on specific medical interventions. References. [Copyright 2005 Elsevier Ltd.] JF - Social Science & Medicine AU - Rodriguez, Keri L AU - Young, Amanda J AD - VA Pittsburgh Health Care System, Center Health Equity Research & Promotion, PA keri.rodriguez@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 125 EP - 133 PB - Elsevier Science, Amsterdam The Netherlands VL - 62 IS - 1 SN - 0277-9536, 0277-9536 KW - USA KW - End-of-life care KW - Life-sustaining treatment KW - Advance care planning KW - Healthcare preferences KW - Qualitative research KW - Veterans KW - Outpatients KW - Health Professions KW - Quality of Health Care KW - Long Term Care KW - Palliative Care KW - United States of America KW - Medical Decision Making KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61350560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Patients%27+and+Healthcare+Providers%27+Understandings+of+Life-Sustaining+Treatment%3A+Are+Perceptions+of+Goals+Shared+or+Divergent%3F&rft.au=Rodriguez%2C+Keri+L%3BYoung%2C+Amanda+J&rft.aulast=Rodriguez&rft.aufirst=Keri&rft.date=2006-01-01&rft.volume=62&rft.issue=1&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2005.05.023 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - United States of America; Health Professions; Medical Decision Making; Palliative Care; Long Term Care; Quality of Health Care; Outpatients DO - http://dx.doi.org/10.1016/j.socscimed.2005.05.023 ER - TY - JOUR T1 - Assets in Intrahousehold Bargaining among Women Workers in Colombia's Cut-Flower Industry AN - 60010782; 200619758 AB - Drawing on ethnographic & survey data, this article examines the diverse ways in which land & home ownership, wage income, & social capital combine to structure the alternatives of women workers in the cut-flower industry of rural Colombia. Most of these workers live in traditional male-dominated households where domestic abuse is prevalent. Data showing rates of property ownership by gender are presented, & the barriers & facilitators to property ownership by gender among agricultural wage-workers are analyzed. Property ownership is acquired largely through inheritance or purchase, which is influenced by social capital & the historical nature of relationships with large landowners. Women's household bargaining strategies rely on a combination of assets: kin networks; labor-related networks; & physical, financial, & individual assets. The author argues that the social capital of individuals, including their labor, kin, & solidarity networks, is key to an understanding of both property acquisition & intrahousehold bargaining processes. Tables, References. Adapted from the source document. JF - Feminist Economics AU - Friedemann-Sanchez, Greta AD - Center Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN Greta.Friedemann-Sanchez@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 247 EP - 269 PB - Taylor & Francis, Abingdon UK VL - 12 IS - 1-2 SN - 1354-5701, 1354-5701 KW - Social capital, property, agricultural labor, domestic violence, non-traditional exports, rural Colombia KW - Working Women KW - Households KW - Wages KW - Agricultural Workers KW - Ownership KW - Colombia KW - Cultural Capital KW - article KW - 0621: complex organization; jobs, work organization, workplaces, & unions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60010782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Feminist+Economics&rft.atitle=Assets+in+Intrahousehold+Bargaining+among+Women+Workers+in+Colombia%27s+Cut-Flower+Industry&rft.au=Friedemann-Sanchez%2C+Greta&rft.aulast=Friedemann-Sanchez&rft.aufirst=Greta&rft.date=2006-01-01&rft.volume=12&rft.issue=1-2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Feminist+Economics&rft.issn=13545701&rft_id=info:doi/10.1080%2F13545700500508551 LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Number of references - 39 N1 - Last updated - 2016-09-28 N1 - CODEN - FEECFE N1 - SubjectsTermNotLitGenreText - Households; Ownership; Wages; Cultural Capital; Working Women; Colombia; Agricultural Workers DO - http://dx.doi.org/10.1080/13545700500508551 ER - TY - JOUR T1 - Patients' and Healthcare Providers' Understandings of Life-Sustaining Treatment: Are Perceptions of Goals Shared or Divergent? AN - 60005450; 200620667 AB - In this cross-sectional qualitative study, researchers performed in-depth, semistructured interviews with 30 pairs of patients & their primary care providers in an outpatient clinic of a large, urban Veterans Affairs (VA) medical center in the United States. During audiotaped interviews to assess their understanding of advance directive concepts, participants were asked what "life-sustaining treatment" means to them & why they think of it in the way they do. The findings indicate that patients & providers in the United States tend to view & discuss life-sustaining treatment in terms of four goals for end-of-life care: (1) extending the length of life, (2) improving the quality of life, (3) maintaining or improving specific biological functions, & (4) assisting the body for a temporary period of time. Patients thought providers were more concerned with extending the length of life than with quality-based outcomes, & patients often discussed life-sustaining treatment as acceptable means for short-term but not long-term use. Many providers indicated that they struggle with conflicting quality-based & physiologic care goals. The findings highlight the importance of eliciting patient preferences not only for specific types of treatment, such as cardiopulmonary resuscitation, but also for end-of-life care goals or desired health-related outcomes, such as maximizing the quantity of life. The findings also suggest that advance directives & patient-provider discussions that focus on acceptable health states & valued life activities may be better suited to patients' end-of-life care goals than those that focus on specific medical interventions. References. [Copyright 2005 Elsevier Ltd.] JF - Social Science & Medicine AU - Rodriguez, Keri L AU - Young, Amanda J AD - VA Pittsburgh Health Care System, Center Health Equity Research & Promotion, PA keri.rodriguez@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 125 EP - 133 PB - Elsevier Science, Amsterdam The Netherlands VL - 62 IS - 1 SN - 0277-9536, 0277-9536 KW - USA KW - End-of-life care KW - Life-sustaining treatment KW - Advance care planning KW - Healthcare preferences KW - Qualitative research KW - Veterans KW - Outpatients KW - Health Professions KW - Quality of Health Care KW - Long Term Care KW - Palliative Care KW - United States of America KW - Medical Decision Making KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60005450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Patients%27+and+Healthcare+Providers%27+Understandings+of+Life-Sustaining+Treatment%3A+Are+Perceptions+of+Goals+Shared+or+Divergent%3F&rft.au=Rodriguez%2C+Keri+L%3BYoung%2C+Amanda+J&rft.aulast=Rodriguez&rft.aufirst=Keri&rft.date=2006-01-01&rft.volume=62&rft.issue=1&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2005.05.023 LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - United States of America; Health Professions; Medical Decision Making; Palliative Care; Long Term Care; Quality of Health Care; Outpatients DO - http://dx.doi.org/10.1016/j.socscimed.2005.05.023 ER - TY - JOUR T1 - Sanctification of Parenting: Links to Corporal Punishment and Parental Warmth Among Biblically Conservative and Liberal Mothers AN - 57219734; 200715821 AB - A growing body of research has examined links between religious beliefs and parenting practices. This study used the theoretical construct of sanctification to examine the degree to which parenting holds spiritual significance and meaning for parents and whether sanctification is related to parenting behaviors. Seventy-four mothers completed questionnaires measuring sanctification of the parenting role, a biblical conservatism scale, and measures of parenting practices. Greater sanctification of parenting was associated with less use of verbal aggression and, to some extent, increased parental consistency. Biblical conservatism moderated the link between sanctification and (a) use of corporal punishment and (b) positive parent-child interactions. Specifically, greater sanctification of parenting was tied to decreased corporal punishment by mothers with liberal biblical beliefs but related to more use of corporal punishment among conservative mothers, greater sanctification was tied to increased positive mother-child interactions by mothers with conservative biblical views but did not alter the uniformly high rates of positivity reported by liberal mothers. Findings are integrated with theoretical work on sanctification and existing empirical research on religion and parenting. Adapted from the source document. JF - The International Journal for the Psychology of Religion AU - Murray-Swank, Aaron AU - Mahoney, Annette AU - Pargament, Kenneth I AD - VA Maryland Healthcare System, MIRECC, Baltimore, MD aaron.murray-swank@med.va.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 271 EP - 287 PB - Lawrence Erlbaum, Mahwah NJ VL - 16 IS - 4 SN - 1050-8619, 1050-8619 KW - Parenting style KW - Religious aspects KW - Corporal punishment KW - Religious beliefs KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57219734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+Journal+for+the+Psychology+of+Religion&rft.atitle=Sanctification+of+Parenting%3A+Links+to+Corporal+Punishment+and+Parental+Warmth+Among+Biblically+Conservative+and+Liberal+Mothers&rft.au=Murray-Swank%2C+Aaron%3BMahoney%2C+Annette%3BPargament%2C+Kenneth+I&rft.aulast=Murray-Swank&rft.aufirst=Aaron&rft.date=2006-01-01&rft.volume=16&rft.issue=4&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=The+International+Journal+for+the+Psychology+of+Religion&rft.issn=10508619&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-08-28 N1 - Last updated - 2016-09-27 N1 - CODEN - IPRLEB N1 - SubjectsTermNotLitGenreText - Religious beliefs; Parenting style; Corporal punishment; Religious aspects ER - TY - JOUR T1 - Patients' and Healthcare Providers' Understandings of Life-Sustaining Treatment: Are Perceptions of Goals Shared or Divergent? AN - 57209378; 200613382 AB - In this cross-sectional qualitative study, researchers performed in-depth, semistructured interviews with 30 pairs of patients & their primary care providers in an outpatient clinic of a large, urban Veterans Affairs (VA) medical center in the United States. During audiotaped interviews to assess their understanding of advance directive concepts, participants were asked what "life-sustaining treatment" means to them & why they think of it in the way they do. The findings indicate that patients & providers in the United States tend to view & discuss life-sustaining treatment in terms of four goals for end-of-life care: (1) extending the length of life, (2) improving the quality of life, (3) maintaining or improving specific biological functions, & (4) assisting the body for a temporary period of time. Patients thought providers were more concerned with extending the length of life than with quality-based outcomes, & patients often discussed life-sustaining treatment as acceptable means for short-term but not long-term use. Many providers indicated that they struggle with conflicting quality-based & physiologic care goals. The findings highlight the importance of eliciting patient preferences not only for specific types of treatment, such as cardiopulmonary resuscitation, but also for end-of-life care goals or desired health-related outcomes, such as maximizing the quantity of life. The findings also suggest that advance directives & patient-provider discussions that focus on acceptable health states & valued life activities may be better suited to patients' end-of-life care goals than those that focus on specific medical interventions. 31 References. [Copyright 2005 Elsevier Ltd.] JF - Social Science & Medicine AU - Rodriguez, Keri L AU - Young, Amanda J AD - VA Pittsburgh Health Care System, Center Health Equity Research & Promotion, PA keri.rodriguez@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 125 EP - 133 PB - Elsevier Science, Amsterdam The Netherlands VL - 62 IS - 1 SN - 0277-9536, 0277-9536 KW - USA KW - End-of-life care KW - Life-sustaining treatment KW - Advance care planning KW - Healthcare preferences KW - Qualitative research KW - Veterans KW - Quality of care KW - Life sustaining treatment KW - End of life decisions KW - Palliative care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57209378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Patients%27+and+Healthcare+Providers%27+Understandings+of+Life-Sustaining+Treatment%3A+Are+Perceptions+of+Goals+Shared+or+Divergent%3F&rft.au=Rodriguez%2C+Keri+L%3BYoung%2C+Amanda+J&rft.aulast=Rodriguez&rft.aufirst=Keri&rft.date=2006-01-01&rft.volume=62&rft.issue=1&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - End of life decisions; Life sustaining treatment; Palliative care; Quality of care DO - http://dx.doi.org/10.1016/j.socscimed.2005.05.023 ER - TY - JOUR T1 - Under-Reporting of Work-Related Musculoskeletal Disorders in the Veterans Administration AN - 57097353; 200704396 AB - Purpose: Work-related musculoskeletal disorders following patient contact represent a major concern for health care workers. Unfortunately, research & prevention have been hampered by difficulties ascertaining true prevalence rates owing to under-reporting of these injuries. The purpose of this study is to determine the predictors for under-reporting work-related musculoskeletal injuries & their reasons. Design/methodology/approach: Multivariate analysis using data obtained in a survey of Veterans Administration employees in the USA was used to determine underreporting patterns among registered nurses, licensed practical nurses & nursing assistants. Focus groups among health care workers were conducted at one of the largest Veterans Administration hospitals to determine reasons for under-reporting. Findings: A significant number of workers reported work-related musculoskeletal pain, which was not reported as an injury but required rescheduling work such as changing shifts & taking sick leave to recuperate. The findings indicate that older health care workers & those with longer service were less likely to report as were those working in the evening & night shifts. Hispanic workers & personnel who had repetitive injuries were prone to under-reporting, as were workers in places that lack proper equipment to move & handle patients. Reasons for under-reporting include the time involved, peer pressure not to report & frustration with workers' compensation procedures. Originality/value: This study provides insights into under-reporting musculoskeletal injuries in a major US government organization. The research indicates that current reporting procedures appear to be overtly cumbersome in time & effort. More flexible work assignments are needed to cover staff shortfalls owing to injuries. Health education on the detrimental long-term effects of ergonomic injuries & the need for prompt attention to injuries should prove useful in improving rates of reporting. Tables, References. Adapted from the source document. JF - International Journal of Health Care Quality Assurance AU - Siddharthan, Kris AU - Hodgson, Michael AU - Rosenberg, Deborah AU - Haiduven, Donna AU - Nelson, Audrey AD - Patient Safety Center Inquiry, James A. Haley Veterans Administration Medical Center, Tampa, FL kris.siddharthan@med.va.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 463 EP - 476 PB - Emerald Group Publishing Ltd., Bradford UK VL - 19 IS - 6-7 SN - 0952-6862, 0952-6862 KW - Injuries KW - Employees KW - Health services sector, Regression analysis, Focus groups, United States of America KW - Health Services KW - Musculoskeletal Diseases KW - Industrial Accidents KW - Underreporting KW - Health Professional-Patient Interactions KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57097353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Health+Care+Quality+Assurance&rft.atitle=Under-Reporting+of+Work-Related+Musculoskeletal+Disorders+in+the+Veterans+Administration&rft.au=Siddharthan%2C+Kris%3BHodgson%2C+Michael%3BRosenberg%2C+Deborah%3BHaiduven%2C+Donna%3BNelson%2C+Audrey&rft.aulast=Siddharthan&rft.aufirst=Kris&rft.date=2006-01-01&rft.volume=19&rft.issue=6-7&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Health+Care+Quality+Assurance&rft.issn=09526862&rft_id=info:doi/10.1108%2F09526860610686971 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-02-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Musculoskeletal Diseases; Underreporting; Health Services; Health Professional-Patient Interactions; Industrial Accidents DO - http://dx.doi.org/10.1108/09526860610686971 ER - TY - JOUR T1 - Physical and Mental Health and Access to Care among Nonmetropolitan Veterans Health Administration Patients Younger than 65 Years AN - 57071758; 200619317 AB - Context: The 4.5 million military veterans treated by the Veterans Health Administration (VA) are believed to experience poorer physical & mental health than nonveterans. Furthermore, nonmetropolitan residents have less access to medical services, whether or not they are veterans in VA care. A direct comparison of metropolitan & nonmetropolitan veterans & nonveterans on a national health survey has not been reported, so it is not known whether nonmetropolitan VA patients experience similar medical need or access as other non metropolitan residents. Purpose: We sought to compare the perceptions of health status & access to care among metropolitan & nonmetropolitan veterans in VA care, other veterans, & nonveterans in a large national sample surveyed under the same conditions. Methods: Male respondents to the 2000 Behavioral Risk Factor Surveillance System health survey were divided into veterans or nonveterans, VA users or nonusers, metropolitan or nonmetropolitan residents, & I of 3 age groups (18-44, 45-64, & 65+). Responses to questions about current health status, health coverage, & access to care were submitted to chi -square analyses or analyses of variance, using SUDAAN software to compute survey error variance. Findings: Nonmetropolitan VA patients younger than 65 years consistently reported the worst physical & mental health status & reduced access to care. Conclusions: VA can anticipate increasing demand for mental & physical health care among rural veterans younger than 65 years. Figures, References. Adapted from the source document. JF - The Journal of Rural Health AU - West, Alan AU - Weeks, William B AD - Center Rural Health Studies, VA Medical Center, White River Junction, VT alan.west@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 9 EP - 16 PB - National Rural Health Association, Kansas City MO VL - 22 IS - 1 SN - 0890-765X, 0890-765X KW - Veterans KW - Health Care KW - Mental Health Care KW - Health KW - Access KW - Metropolitan Areas KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57071758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health&rft.atitle=Physical+and+Mental+Health+and+Access+to+Care+among+Nonmetropolitan+Veterans+Health+Administration+Patients+Younger+than+65+Years&rft.au=West%2C+Alan%3BWeeks%2C+William+B&rft.aulast=West&rft.aufirst=Alan&rft.date=2006-01-01&rft.volume=22&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health&rft.issn=0890765X&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-29 N1 - Last updated - 2016-09-27 N1 - CODEN - JRHEEX N1 - SubjectsTermNotLitGenreText - Veterans; Access; Health; Health Care; Mental Health Care; Metropolitan Areas ER - TY - JOUR T1 - "Stereotypic" Delusional Offending AN - 57044356; 200614733 AB - Some patients with serious mental illness appear to respond violently to the same delusional content throughout the course of their illness. Anecdotal, empirical, & theoretical evidence is presented establishing the premise of "stereotypic" delusional offending. A method for measuring the similarity of two delusions separated in time also is presented. An empirical focus on stereotypic delusional offending may help identify more accurately persons at risk for violence & those at risk for becoming targets of violence. It also may provide a better understanding of successful treatment of outpatient violence & conceivably could inform the ongoing debate on involuntary outpatient commitment laws. Among the major issues of this debate in the United States are the potential benefits of a forced medication provision. One rationale for such a provision may be found in the treatment response of seriously mentally ill outpatients whose violent behavior appears inescapably tied to their persistent or recurrent delusions. 2 Tables, 3 Figures, 37 References. [Copyright 2006 John Wiley and Sons, Ltd.] JF - Behavioral Sciences & the Law AU - Junginger, John AD - Veterans' Administration Maryland Health Care System, U Maryland, School Medicine, Baltimore john.junginger@med.va.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 295 EP - 311 PB - John Wiley & Sons, Chichester UK VL - 24 IS - 3 SN - 0735-3936, 0735-3936 KW - Delusions KW - Violence KW - Risks KW - Offending KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57044356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Sciences+%26+the+Law&rft.atitle=%22Stereotypic%22+Delusional+Offending&rft.au=Junginger%2C+John&rft.aulast=Junginger&rft.aufirst=John&rft.date=2006-01-01&rft.volume=24&rft.issue=3&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Behavioral+Sciences+%26+the+Law&rft.issn=07353936&rft_id=info:doi/10.1002%2Fbsl.682 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-10-02 N1 - Last updated - 2016-09-27 N1 - CODEN - BSLADR N1 - SubjectsTermNotLitGenreText - Delusions; Offending; Violence; Risks DO - http://dx.doi.org/10.1002/bsl.682 ER - TY - JOUR T1 - Gene therapy, cell transplantation and stroke AN - 21210221; 11197567 AB - The use of neuroteratocarcinoma cells for transplantation therapy in stroke has emerged as a strategy for cell replacement therapy that has begun its transition from basic science laboratories to a clinical setting. Procurement logistics and novel neuroprotective functions associated with these cells allow neuroteratocarcinoma cells to serve as efficacious alternatives to using fetal cells as donor cell grafts for stroke therapy, although the optimal transplantation regimen must still be determined. In particular, the limitations of current stroke treatments and management reveal an urgent need to examine the efficacy of experimental treatments, such as neural transplantation, in order to develop better treatment therapies. This chapter will discuss the characteristics of NT2N cells, the role of the host brain microenvironment, the need for more rigorous laboratory research and clinical trials for the intracerebral transplantation of NT2N cells in stroke, the mechanisms underlying the grafts' beneficial effects, and the need for immunosuppression. This chapter will highlight some of the most recent findings regarding NT2N cells. JF - Frontiers in Bioscience AU - Borlongan, C V AU - Fournier, C AU - Stahl, CE AU - Yu, G AU - Xu, L AU - Matsukawa, N AU - Newman, M AU - Yasuhara, T AU - Hara, K AU - Hess, D C AU - Sanberg, PR AD - Department of Neurology, Medical College of Georgia, Augusta Veterans Administration Medical Center, Augusta GA 30912, USA Y1 - 2006 PY - 2006 DA - 2006 SP - 1090 EP - 1100 VL - 11 SN - 1093-9946, 1093-9946 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Transplantation KW - Gene therapy KW - Stroke KW - Brain KW - Microenvironments KW - Neuroprotection KW - Clinical trials KW - Fetuses KW - Immunosuppression KW - W 30905:Medical Applications KW - N3 11023:Neurogenetics KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21210221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+Bioscience&rft.atitle=Gene+therapy%2C+cell+transplantation+and+stroke&rft.au=Borlongan%2C+C+V%3BFournier%2C+C%3BStahl%2C+CE%3BYu%2C+G%3BXu%2C+L%3BMatsukawa%2C+N%3BNewman%2C+M%3BYasuhara%2C+T%3BHara%2C+K%3BHess%2C+D+C%3BSanberg%2C+PR&rft.aulast=Borlongan&rft.aufirst=C&rft.date=2006-01-01&rft.volume=11&rft.issue=&rft.spage=1090&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+Bioscience&rft.issn=10939946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Transplantation; Gene therapy; Stroke; Brain; Microenvironments; Neuroprotection; Clinical trials; Fetuses; Immunosuppression ER - TY - JOUR T1 - Sun exposure, sexual behavior and uterine cervical human papilloma virus AN - 20962731; 6669418 AB - We have previously observed marked seasonal fluctuations in the frequency of cervical smears positive for human papilloma virus (HPV) in a series of smears obtained in Holland, with a peak in the summer months, especially August. Here, we tested two possible mechanisms that might underlie this summer peak: (1) enhanced transmission of HPV due to increased seasonal sexual activity, or (2) suppression of immunity due to summertime population exposure to solar ultraviolet (UV) radiation. Data derived from a continuous series of >900,000 independent cervical smears obtained from 1983 to 1998 were assessed for histopathologic epithelial changes pathognomonic of HPV. The rate of HPV positivity was then compared to both the rate of sexual activity (using conception frequency as a readily available surrogate) as well as yearly and monthly fluctuations in solar-UV fluency. The rate of HPV positivity was found to be twice as high during the summer months, with a peak in August corresponding with maximal UV fluency. Furthermore, over these 16 consecutive years of continuous observation, maximum HPV detection rate and maximum UV fluency are positively correlated (r=0.59, P<0.01); the sunnier the year, the greater the rate of HPV. Likewise, there is a positive correlation of the monthly UV fluency, and monthly HPV discovery rate (r=0.16, P<0.03). In contrast, conception frequency (and, presumably, population sexual HPV transmission) was maximal near the vernal equinox, with relatively modest (<10%) seasonal fluctuation, i.e., not fully explaining this prominent August peak in HPV discovery. There is a clear relationship between the detection of HPV-positive cervical smears and sunlight exposure. We speculate that the well-known phenomenon of UV-mediated suppression of immune surveillance may be causally related to this unusual increase in cytologically defined active HPV infections during the summer months in northern countries such as Holland. Confirming this relationship elsewhere may be important, because whatever the risk conferred by sunlight is, in principle, behaviorally avoidable. JF - International Journal of Biometeorology AU - Hrushesky, WJM AU - Sothern, R B AU - Rietveld, W J AU - Du-Quiton, J AU - Boon, ME AD - Epidemiology and Biostatistics, Norman J. Arnold School of Public Health, University of South Carolina School of Medicine, Columbia, SC, USA, william.hrushesky@va.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 167 EP - 173 VL - 50 IS - 3 SN - 0020-7128, 0020-7128 KW - Virology & AIDS Abstracts; Risk Abstracts KW - sexual behavior KW - Uterus KW - Data processing KW - disease transmission KW - Immunity KW - sunlight KW - Infection KW - Sexual behavior KW - sun KW - Disease transmission KW - Sulfur dioxide KW - U.V. radiation KW - Immunosurveillance KW - Ultraviolet radiation KW - Sun KW - infection KW - summer KW - Sunlight KW - Cervix KW - Seasonal variations KW - Human papillomavirus KW - V 22350:Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20962731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=Expression+of+the+proto-oncogene+eIF4E+in+inflammation+of+the+oral+cavity.&rft.au=Chandy%2C+Binoy%3BAbreo%2C+Fleurette%3BNassar%2C+Raja%3BStucker%2C+Fred+J%3BNathan%2C+Cherie-Ann&rft.aulast=Chandy&rft.aufirst=Binoy&rft.date=2002-03-01&rft.volume=126&rft.issue=3&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Uterus; Data processing; U.V. radiation; Immunosurveillance; Sun; Sunlight; Immunity; Infection; Cervix; Sexual behavior; Disease transmission; sexual behavior; Sulfur dioxide; disease transmission; Ultraviolet radiation; infection; summer; sunlight; Seasonal variations; sun; Human papillomavirus ER - TY - JOUR T1 - Gastrointestinal endoscopic findings in men with unexplained anemia and low normal ferritin values AN - 20862147; 6837822 AB - Background: Most practice guidelines recommend endoscopic evaluation of the gastrointestinal (GI) tract in men and postmenopausal women with anemia and a serum ferritin less than 20-40 ng/ml. The diagnostic yield of endoscopy in patients with anemia, no GI symptoms or signs, and low normal ferritin is not known. Objective: The aim of this study was to investigate the yield of upper and lower GI endoscopic evaluations in anemic patients with ferritin levels between 40 and 100 ng/ml. Design: A retrospective review of patients' charts was conducted. Subjects and methods: Patients at the Veterans Affairs Connecticut Healthcare System who underwent GI endoscopic evaluation for the sole indication of anemia and ferritin in the low normal range (40-100 ng/ml) were included in this study. Measurements: Incidence of pathology of the upper and lower GI tract was determined. Results: We identified 54 male patients who had a ferritin level of 40-100 ng/ml and no GI symptoms or known GI bleeding. Upper GI findings (malignancy, peptic ulcers, Helicobacter pylori gastritis, arteriovenous malformations) were found in 14/47 cases (30%). Lower gastrointestinal findings, including large tubular adenomas and arteriovenous malformation, were identified in 3/53 cases (6.7%). Conclusion: Our study supports GI endoscopy in anemic patients with ferritin between 40 and 100 ng/ml, even in the absence of GI symptoms or documented bleeding. Am. J. Hematol. 81:324-327, 2006. JF - American Journal of Hematology AU - Wang, Sa A AU - Fadare, Oluwole AU - Nagar, Anil AU - Shafi, Nelofar Q AU - Rose, Michal G AD - Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts, Michal.Rose@va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 324 EP - 327 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 81 IS - 5 SN - 0361-8609, 0361-8609 KW - Microbiology Abstracts B: Bacteriology KW - iron deficiency anemia ferritin endoscopy KW - Helicobacter pylori KW - Malignancy KW - Post-menopause KW - Anemia KW - Bleeding KW - Ferritin KW - peptic ulcers KW - Gastrointestinal tract KW - Adenoma KW - Gastritis KW - Endoscopy KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20862147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Hematology&rft.atitle=Gastrointestinal+endoscopic+findings+in+men+with+unexplained+anemia+and+low+normal+ferritin+values&rft.au=Wang%2C+Sa+A%3BFadare%2C+Oluwole%3BNagar%2C+Anil%3BShafi%2C+Nelofar+Q%3BRose%2C+Michal+G&rft.aulast=Wang&rft.aufirst=Sa&rft.date=2006-01-01&rft.volume=81&rft.issue=5&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Hematology&rft.issn=03618609&rft_id=info:doi/10.1002%2Fajh.20613 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Malignancy; Post-menopause; Bleeding; Anemia; peptic ulcers; Ferritin; Gastrointestinal tract; Gastritis; Adenoma; Endoscopy; Helicobacter pylori DO - http://dx.doi.org/10.1002/ajh.20613 ER - TY - JOUR T1 - Laboratory-acquired infections: Are microbiologists at risk? AN - 19710192; 7583399 AB - Exposure of laboratory workers to infectious agents in the clinical microbiology laboratory continues to be an occupational risk. This risk is mitigated by the application of safety guidelines issued by regulatory agencies and professional organizations. The Clinical and Laboratory Standards Institute (fomerly NCCLS) published a guidance document (M29-A3) in 2005 on the risk of transmission of infectious agents in the laboratory, preventative measures to reduce risk, and management of exposure to infectious agents. The key to a safe workplace is employees who are knowledgeable of the routes of transmission of infectious agents in the laboratory setting and apply safety principles and work practices to reduce the risk. JF - Clinical Microbiology Newsletter AU - Sewell, David L AD - Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center and Department of Pathology, Oregon Health and Science University, Portland, Oregon, david.sewell@med.va.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 1 EP - 6 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 28 IS - 1 SN - 0196-4399, 0196-4399 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts KW - Risk assessment KW - risk reduction KW - guidelines KW - infection KW - microbiologists KW - Infection KW - Occupational exposure KW - A 01450:Environmental Pollution & Waste Treatment KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19710192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+Newsletter&rft.atitle=Laboratory-acquired+infections%3A+Are+microbiologists+at+risk%3F&rft.au=Sewell%2C+David+L&rft.aulast=Sewell&rft.aufirst=David&rft.date=2006-01-01&rft.volume=28&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+Newsletter&rft.issn=01964399&rft_id=info:doi/10.1016%2Fj.clinmicnews.2005.12.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Infection; Occupational exposure; risk reduction; guidelines; microbiologists; infection DO - http://dx.doi.org/10.1016/j.clinmicnews.2005.12.004 ER - TY - JOUR T1 - Cytokine-containing gelfoam implants at a postsurgical tumor excision site to stimulate local immune reactivity AN - 19443658; 6837541 AB - We previously demonstrated increased numbers of CD34 super(+) progenitor cells in the peripheral blood of tumor bearers. Also demonstrated was the feasibility of chemoattracting these cells by sponge implants containing VEGF. The present study used a murine Lewis lung carcinoma (LLC) model to test if CD34 super(+) cells that are chemoattracted to a tumor excision site can be differentiated in situ into dendritic cells and whether this leads to increased local immune reactivity. After surgically excising established LLC tumors, mice received at the excision site gelatin sponge implants containing VEGF to chemoattract CD34 super(+) cells, and/or GM-CSF plus SCF to induce CD34 super(+) cell differentiation into dendritic cells. In some studies, lysates of GFP-transfected LLC cells (LLC super(GFP)) were also included in the implants as a source of tumor antigen. After 2 weeks, implants and local lymph nodes were removed and analyzed. Implants containing VEGF, GM-CSF/SCF or VEGF/GM-CSF/SCF had a higher proportion of CD34 super(+) cells compared to control implants. However, the number of dendritic cells was higher in implants containing GM-CSF/SCF or VEGF/GM-CSF/SCF than those containing either VEGF or diluent. Regional lymph node from mice containing GM-CSF/SCF or VEGF/GM-CSF/SCF implants showed increased dendritic cell levels. However, when lysates from LLC super(GFP) were added to the implants, the highest proportion of dendritic cells associated with GFP was in lymph nodes of mice containing GM-CSF/SCF implants. Lymph node cells from mice with GM- CSF/SCF or VEGF/GM-CSF/SCF had a higher level of proliferation and IFN-[gamma] secretion in response to in vitro LLC lysate challenge, with the greatest response being from lymph node cells of mice with GM-CSF/SCF implants. These results suggest the feasibility of using GM-CSF/SCF-containing implants to increase dendritic cell levels, uptake of tumor antigens, trafficking to lymph nodes and stimulation of immune reactivity at tumor excision sites with residual tumor. JF - International Journal of Cancer AU - Young, MRita I AD - Department of Research Services, Ralph H. Johnson V.A. Medical Center, Charleston, SC, USA, rita.young@med.va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 133 EP - 138 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 1 SN - 0020-7136, 0020-7136 KW - Biotechnology and Bioengineering Abstracts KW - Vascular endothelial growth factor KW - Lung carcinoma KW - Gelatin KW - Animal models KW - Granulocyte-macrophage colony-stimulating factor KW - Peripheral blood KW - CD34 antigen KW - Tumors KW - Diluents KW - Lymph nodes KW - Differentiation KW - Dendritic cells KW - Stem cells KW - Antigen (tumor-associated) KW - Hemopoiesis KW - Cell proliferation KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19443658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Cytokine-containing+gelfoam+implants+at+a+postsurgical+tumor+excision+site+to+stimulate+local+immune+reactivity&rft.au=Young%2C+MRita+I&rft.aulast=Young&rft.aufirst=MRita&rft.date=2006-01-01&rft.volume=119&rft.issue=1&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Granulocyte-macrophage colony-stimulating factor; Vascular endothelial growth factor; Tumors; Dendritic cells; Lymph nodes; CD34 antigen; Antigen (tumor-associated); Diluents; Stem cells; Animal models; Peripheral blood; Differentiation; Gelatin; Hemopoiesis; Cell proliferation; Lung carcinoma DO - http://dx.doi.org/10.1002/ijc.21806 ER - TY - JOUR T1 - Beta-Blockade Mitigates Exercise Blood Pressure in Hypertensive Male Patients AN - 17177373; 6820252 AB - The purpose of this study was to determine the antihypertensive agent(s) more likely to mitigate an exaggerated rise in exercise blood pressure (BP) in hypertensive patients. Background An exaggerated rise in exercise BP is associated with increased cardiovascular risk. There are no recommendations for treating such response. Methods Participants were hypertensive men (n = 2,318; age 60 +/- 10 years), undergoing a routine exercise test at the Veterans Affairs Medical Center, Washington, DC. Antihypertensive therapy included angiotensin- converting enzyme inhibitors (n = 437), calcium-channel blockers (n = 223), diuretics (n = 226), and combinations (n = 1,442), beta-blockers alone (n = 201) or in combination with other antihypertensive agents (n = 467), and none (n = 208). Exercise BP, heart rate (HR) and rate-pressure product (RPP) at maximal and submaximal workloads were assessed. Results After adjusting for covariates, patients treated with beta-blockers or beta-blocker-based therapy had significantly lower BP, HR, and RPP at 5 and 7 metabolic equivalents (METs) and peak exercise than those treated with any other antihypertensive agent or combination (p - 0.05). The likelihood of achieving an exercise systolic BP of >=210 mm Hg was 68% lower (odds ratio = 0.32, 96% confidence interval 0.2 to 0.53) in the beta-blocker-based therapy versus other medications. African Americans exhibited higher BP and HR than Caucasians at all exercise workloads regardless of antihypertensive therapy and had over a 90% higher likelihood for an abnormal exercise BP response. This risk was attenuated by 35% with a beta- blocker-based therapy. Conclusions Significantly lower exercise BP, HR, and RPP levels are achieved with beta-blocker-based therapy than with other antihypertensive agents regardless of race. However, BP was better controlled in Caucasians than in African Americans regardless of antihypertensive therapy. Beta-Blockade Mitigates Exercise Blood Pressure in Hypertensive Male Patients Peter Kokkinos, Christina Chrysohoou, Demosthenes Panagiotakos, Puneet Narayan, Michael Greenberg, Steve Singh We assessed 2,318 hypertensive male patients treated with various antihypertensive agents to determine the exercise blood pressure (BP) response. Patients treated with beta-blockers had significantly lower exercise BP than those treated with any other agent or combination. The likelihood of achieving an exercise systolic BP of >=210 mm Hg was also significantly lower on beta-blocker-based therapy compared with any other therapy. Because repetitive exposure to high hemodynamic loads is associated with cardiovascular events, beta-blockade therapy is more likely to protect against excessive and repetitive elevations in BP which may occur during daily bouts of physical exertion in hypertensive patients. JF - Journal of the American College of Cardiology AU - Kokkinos, Peter AU - Chrysohoou, Christina AU - Panagiotakos, Demosthenes AU - Narayan, Puneet AU - Greenberg, Michael AU - Singh, Steve AD - Cardiology Division, Veterans Affairs and Georgetown University Medical Centers, Washington, DC., peter.kokkinos@med.va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 794 EP - 798 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.com] VL - 47 IS - 4 SN - 0735-1097, 0735-1097 KW - Physical Education Index KW - Blacks KW - Men KW - Heart rate KW - Medications KW - Therapy KW - Enzymes KW - Hemodynamics KW - Patients KW - Exercise KW - Exertion KW - Blood pressure KW - Higher education KW - Recruiting KW - Cardiorespiratory KW - Work load KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17177373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Beta-Blockade+Mitigates+Exercise+Blood+Pressure+in+Hypertensive+Male+Patients&rft.au=Kokkinos%2C+Peter%3BChrysohoou%2C+Christina%3BPanagiotakos%2C+Demosthenes%3BNarayan%2C+Puneet%3BGreenberg%2C+Michael%3BSingh%2C+Steve&rft.aulast=Kokkinos&rft.aufirst=Peter&rft.date=2006-01-01&rft.volume=47&rft.issue=4&rft.spage=794&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/10.1016%2Fj.jacc.2005.09.057 LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Men; Blacks; Heart rate; Therapy; Medications; Hemodynamics; Enzymes; Patients; Exercise; Exertion; Blood pressure; Recruiting; Higher education; Work load; Cardiorespiratory DO - http://dx.doi.org/10.1016/j.jacc.2005.09.057 ER - TY - JOUR T1 - Can initial and additional compensatory steps be predicted in young, older, and balance-impaired older females in response to anterior and posterior waist pulls while standing? AN - 17168117; 6839305 AB - The initiation of a single compensatory step in response to balance perturbations has been predicted with accuracies of up to 71%. We sought to determine whether similar methods also could be used to predict the onset of additional compensatory steps in both healthy and balance-impaired older females. Anterior and posterior waist pulls of five different magnitudes were applied to 13 unimpaired young (mean age 23 years), 12 unimpaired older (mean age 71 years), and 15 balance-impaired older (mean age 76 years) women. Body segment kinematic data were recorded at 100 Hz. A step was predicted when the time for the center-of-mass to reach the vertical projection of the boundary of the base-of-support fell below a certain threshold. The results show that 83% of all steps and non-steps were correctly predicted at an optimal time-to-boundary threshold ( tau sub(opt)) of 0.78 s. Step prediction accuracy did not differ significantly by group: 86% of steps and non-steps by young, 84% by unimpaired old, and 82% by balance-impaired old women were correctly predicted at tau sub(opt) of 0.58, 0.67, and 0.78 s, respectively. Anterior steps and non- steps were predicted more accurately than posterior ones (94% vs. 79% correct at tau sub(opt) of 0.52 and 0.84 s, respectively) and initial steps were better predicted than additional ones (87% vs. 81% correct at tau sub(opt) of 0.77 and 0.34 s, respectively). We conclude that this step prediction method reasonably predicts initial and additional steps in the anterior and posterior direction by all three subject cohorts. JF - Journal of Biomechanics AU - Schulz, Brian W AU - Ashton-Miller, James A AU - Alexander, Neil B AD - Biomechanics Research Laboratory, Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA, brian.Schulz@med.va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1444 EP - 1453 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 39 IS - 8 SN - 0021-9290, 0021-9290 KW - Physical Education Index KW - Stepping KW - Perturbation KW - Falls KW - Postural control KW - Aging KW - Kinematics KW - Waist KW - Women KW - Gerontology KW - Accuracy KW - Health KW - Standing KW - Balance KW - Youth KW - Biomechanics KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17168117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanics&rft.atitle=Can+initial+and+additional+compensatory+steps+be+predicted+in+young%2C+older%2C+and+balance-impaired+older+females+in+response+to+anterior+and+posterior+waist+pulls+while+standing%3F&rft.au=Kausch%2C+Otto%3BMcCormick%2C+Richard+A&rft.aulast=Kausch&rft.aufirst=Otto&rft.date=2002-03-01&rft.volume=22&rft.issue=2&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Kinematics; Waist; Women; Gerontology; Accuracy; Health; Standing; Balance; Biomechanics; Youth DO - http://dx.doi.org/10.1016/j.jbiomech.2005.04.004 ER - TY - JOUR T1 - Evaluating potentially aberrant outpatient prescriptions for extended-release oxycodone. AN - 68874679; 16333058 JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Goodman, Francine D C AU - Glassman, Peter AD - Veterans Health Administration, Pharmacy Benefits Management Strategic Healthcare Group, Hines, IL 60141, USA. francine.goodman@med.va.gov Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 SP - 2604 EP - 2608 VL - 62 IS - 24 SN - 1079-2082, 1079-2082 KW - Analgesics, Opioid KW - 0 KW - Delayed-Action Preparations KW - Narcotics KW - Oxycodone KW - CD35PMG570 KW - Index Medicus KW - Veterans KW - United States KW - Outpatients KW - United States Department of Veterans Affairs KW - Humans KW - Databases, Factual KW - Opioid-Related Disorders -- prevention & control KW - Drug Utilization Review KW - Drug Prescriptions -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68874679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Evaluating+potentially+aberrant+outpatient+prescriptions+for+extended-release+oxycodone.&rft.au=Goodman%2C+Francine+D+C%3BGlassman%2C+Peter&rft.aulast=Goodman&rft.aufirst=Francine+D&rft.date=2005-12-15&rft.volume=62&rft.issue=24&rft.spage=2604&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-01 N1 - Date created - 2005-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Gulf War Veterans' Perceptions of Illness, Exposure Concerns, and Health Risk Communication Preferences T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39917509; 4088394 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Schneiderman, Aaron I AU - Wargo, Mary K AU - Lincoln, Andrew E AU - Curbow, Barbara A AU - Kang, Han K Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Occupational health KW - Communication KW - Perception KW - Military KW - Gulf War KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39917509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Gulf+War+Veterans%27+Perceptions+of+Illness%2C+Exposure+Concerns%2C+and+Health+Risk+Communication+Preferences&rft.au=Schneiderman%2C+Aaron+I%3BWargo%2C+Mary+K%3BLincoln%2C+Andrew+E%3BCurbow%2C+Barbara+A%3BKang%2C+Han+K&rft.aulast=Schneiderman&rft.aufirst=Aaron&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence-Based Design: A More Effective Smoking Cessation Model for Women Veterans T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39849489; 4085339 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Katzburg, Judith AU - Farmer, Melissa M AU - Sherman, Scott AU - Poza, Ines Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Smoking KW - Models KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39849489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Evidence-Based+Design%3A+A+More+Effective+Smoking+Cessation+Model+for+Women+Veterans&rft.au=Katzburg%2C+Judith%3BFarmer%2C+Melissa+M%3BSherman%2C+Scott%3BPoza%2C+Ines&rft.aulast=Katzburg&rft.aufirst=Judith&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exposures of Concern for Veterans of the Vietnam War, the Persian Gulf War (1991), and the Bosnia-Kosovo Peacekeeping Activity T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39825575; 4086295 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Schneiderman, Aaron I AU - Lincoln, Andrew E AU - Wargo, Mary K AU - Curbow, Barbara A AU - Kang, Han K Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Arabian Sea, Persian Gulf KW - Vietnam KW - Gulf War KW - War KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39825575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Exposures+of+Concern+for+Veterans+of+the+Vietnam+War%2C+the+Persian+Gulf+War+%281991%29%2C+and+the+Bosnia-Kosovo+Peacekeeping+Activity&rft.au=Schneiderman%2C+Aaron+I%3BLincoln%2C+Andrew+E%3BWargo%2C+Mary+K%3BCurbow%2C+Barbara+A%3BKang%2C+Han+K&rft.aulast=Schneiderman&rft.aufirst=Aaron&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Surveillance of Rectal Cancer Patients After Potentially Curative Initial Treatment T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39816710; 4086050 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Johnson, Frank E AU - Lee, Paul A AU - McGarry, Alaine E AU - Gammon, Steven R AU - Grossmann, Erik M AU - Longo, Walter E AU - Ode, Kenichi AU - Audisio, Riccardo A AU - Shariff, Umar S AU - Papettas, Trifonas AU - Virgo, Katherine S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Cancer KW - Rectum KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39816710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Surveillance+of+Rectal+Cancer+Patients+After+Potentially+Curative+Initial+Treatment&rft.au=Johnson%2C+Frank+E%3BLee%2C+Paul+A%3BMcGarry%2C+Alaine+E%3BGammon%2C+Steven+R%3BGrossmann%2C+Erik+M%3BLongo%2C+Walter+E%3BOde%2C+Kenichi%3BAudisio%2C+Riccardo+A%3BShariff%2C+Umar+S%3BPapettas%2C+Trifonas%3BVirgo%2C+Katherine+S&rft.aulast=Johnson&rft.aufirst=Frank&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Acute and Chronic Discrimination on Unmet Medical Needs T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39776843; 4086013 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Burgess, Diana AU - Hargreaves, Margaret AU - Van Ryn, Michelle AU - Ding, Yingmei AU - Chiezah, Michelle AU - Swaney, Sheldon Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Discrimination KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39776843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Effect+of+Acute+and+Chronic+Discrimination+on+Unmet+Medical+Needs&rft.au=Burgess%2C+Diana%3BHargreaves%2C+Margaret%3BVan+Ryn%2C+Michelle%3BDing%2C+Yingmei%3BChiezah%2C+Michelle%3BSwaney%2C+Sheldon&rft.aulast=Burgess&rft.aufirst=Diana&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - War-Related Illness and Injury Study Centers: A Resource for Deployment-Related Health Concerns T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39766381; 4086253 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Schneiderman, Aaron I AU - Lincoln, Andrew E AU - Helmer, Drew AU - Copeland, H Liesel AU - Prisco, Michelle K AU - Lange, Gudrun AU - Kang, Han K AU - Natelson, Benjamin H Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Injuries KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39766381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=War-Related+Illness+and+Injury+Study+Centers%3A+A+Resource+for+Deployment-Related+Health+Concerns&rft.au=Schneiderman%2C+Aaron+I%3BLincoln%2C+Andrew+E%3BHelmer%2C+Drew%3BCopeland%2C+H+Liesel%3BPrisco%2C+Michelle+K%3BLange%2C+Gudrun%3BKang%2C+Han+K%3BNatelson%2C+Benjamin+H&rft.aulast=Schneiderman&rft.aufirst=Aaron&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Past Experience of a Chemical/Biological Threat: Perceptions and Information Needs of Gulf War I Veterans Over a Decade Later T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39760766; 4088393 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Wargo, Mary K AU - Schneiderman, Aaron I AU - Curbow, Barbara A AU - Kang, Han K AU - Green, Stephanie M Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Perception KW - Gulf War KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39760766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Past+Experience+of+a+Chemical%2FBiological+Threat%3A+Perceptions+and+Information+Needs+of+Gulf+War+I+Veterans+Over+a+Decade+Later&rft.au=Wargo%2C+Mary+K%3BSchneiderman%2C+Aaron+I%3BCurbow%2C+Barbara+A%3BKang%2C+Han+K%3BGreen%2C+Stephanie+M&rft.aulast=Wargo&rft.aufirst=Mary&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Antibiotics and gastrointestinal colonization by vancomycin-resistant enterococci AN - 872136608; 14052307 AB - Although several classes of antimicrobial agents have been associated with colonization or infection with glycopeptide-resistant enterococci (GRE) in individual clinical studies, the agents most commonly implicated are extended-spectrum cephalosporins and compounds with potent activity against anaerobic bacteria, including ticarcillin-clavulanic acid. In some clinical studies, formulary alterations designed to minimize the use of extended-spectrum cephalosporins or ticarcillin-clavulanic acid have resulted in significant decreases in colonization and infection by GRE. Experimental data using a mouse model of GRE gastrointestinal colonization indicate that persistence of high-level GRE colonization of the mouse gastrointestinal tract is promoted by exposure to agents with potent activity against anaerobic bacteria, suggesting that reduction of competing flora is the major factor leading to persistence of high-level colonization. One study performed in humans is consistent with this model and suggests that high levels of colonization may promote spread of resistant organisms in the nosocomial setting. Establishing colonization with GRE in uncolonized mice correlates with exposure to agents that are (a) secreted into the bile in significant concentrations and (b) have negligible activity against the colonizing enterococcal strain. Differences between piperacillin-tazobactam and ceftriaxone in the establishment model can be attributed directly to differences in their anti-enterococcal activity. Modification of antimicrobial prescribing practices may play an important role in facilitating successful infection control efforts to limit GRE in the nosocomial setting. JF - European Journal of Clinical Microbiology & Infectious Diseases AU - Rice, L B AD - Medical Service 111(W), Louis Stokes Cleveland VA Medical Center and Case Medical School, 10701 East Boulevard, Cleveland, OH 44106, USA, louis.rice@med.va.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 804 EP - 814 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 24 IS - 12 SN - 0934-9723, 0934-9723 KW - Microbiology Abstracts B: Bacteriology KW - piperacillin-tazobactam KW - Cephalosporins KW - Data processing KW - Animal models KW - Antibiotics KW - Ceftriaxone KW - Infection KW - Antimicrobial agents KW - Colonization KW - Bile KW - Gastrointestinal tract KW - Anaerobic bacteria KW - Hospitals KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872136608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.atitle=Antibiotics+and+gastrointestinal+colonization+by+vancomycin-resistant+enterococci&rft.au=Rice%2C+L+B&rft.aulast=Rice&rft.aufirst=L&rft.date=2005-12-01&rft.volume=24&rft.issue=12&rft.spage=804&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.issn=09349723&rft_id=info:doi/10.1007%2Fs10096-005-0057-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - piperacillin-tazobactam; Cephalosporins; Data processing; Animal models; Antibiotics; Ceftriaxone; Infection; Antimicrobial agents; Colonization; Bile; Gastrointestinal tract; Hospitals; Anaerobic bacteria DO - http://dx.doi.org/10.1007/s10096-005-0057-z ER - TY - JOUR T1 - Posttraumatic Growth among American Former Prisoners of War AN - 867734484; 13474365 AB - Posttraumatic growth was assessed in a community sample of 95 former prisoners of war studied over a 12 year period. Developmental history, personality, social support, and PTSD measures from two earlier time points were used to predict current scores on the Posttraumatic Growth Inventory (PTGI). We hypothesized positive predictive relationships between PTGI indices and trauma exposure (and corresponding distress levels), positive affect, and social support. Positive Affectivity, Constraint, and two Social Support measures followed a pattern of significant and near-significant positive correlations with PTGI total score, Relationships with Others, and Spiritual Change, suggesting multidirectional relationships among these variables. POW trauma exposure correlated with Perceived Strength. Regression analyses significantly predicted PTGI total score, Improved Relationships, and Spiritual Change. The results both lend support to and raise questions about the construct validity of the PTGI. JF - Traumatology AU - Erbes, Christopher AU - Eberly, Raina AU - Dikel, Thomas AU - Johnsen, Erica AU - Harris, Irene AU - Engdahl, Brian AD - U.S. Department of Veterans Affairs Medical Center, Minneapolis, Minnesota, brian.engdahl@med.va.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 285 EP - 295 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 11 IS - 4 SN - 1534-7656, 1534-7656 KW - Health & Safety Science Abstracts KW - Historical account KW - posttraumatic stress disorder KW - personality KW - war KW - prisons KW - Growth KW - Perception KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867734484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traumatology&rft.atitle=Posttraumatic+Growth+among+American+Former+Prisoners+of+War&rft.au=Erbes%2C+Christopher%3BEberly%2C+Raina%3BDikel%2C+Thomas%3BJohnsen%2C+Erica%3BHarris%2C+Irene%3BEngdahl%2C+Brian&rft.aulast=Erbes&rft.aufirst=Christopher&rft.date=2005-12-01&rft.volume=11&rft.issue=4&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Traumatology&rft.issn=15347656&rft_id=info:doi/10.1177%2F153476560501100407 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - prisons; Historical account; Growth; posttraumatic stress disorder; Perception; personality; war DO - http://dx.doi.org/10.1177/153476560501100407 ER - TY - JOUR T1 - Tinidazole: a nitroimidazole antiprotozoal agent. AN - 70135081; 16507373 AB - Tinidazole, a structural analogue of metrondazole, is an antiprotozoal agent that has been widely used in Europe and developing countries for >2 decades with established efficacy and acceptable tolerability. It was recently approved by the US Food and Drug Administration for the treatment of trichomoniasis, giardiasis, amebiasis, and amebic liver abscess. This article reviews the pharmacologic and pharmacokinetic properties and clinical usefulness of tinidazole. Relevant information was identified through a search of MEDLINE (1966-August 2005), Iowa Drug Information Service (1966-August 2005), and International Pharmaceutical Abstracts (1970-August 2005) using the terms tinidazole, Fasigyn, and nitroimidazole. In vitro, tinidazole exhibits activity against pathogenic protozoa (eg, Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis), a wide range of clinically significant anaerobic bacteria (eg, Bacteroides fragilis, Clostridium difficile), and the microaerophilic bacterium Helicobacter pylori. In susceptible protozoal and bacterial cells, tinidazole is reduced to cytotoxic intermediates that covalently bind to DNA, causing irreversible damage. In human adults, tinidazole had a bioavailability of 100% and a V(d) of 50.7 L, was minimally bound to plasma protein (12%), had a plasma elimination t((1/2)) of 12.3 hours, and was eliminated primarily by hepatic metabolism (approximately 63%). Dose adjustment does not appear to be necessary on the basis of race, sex, or renal function. No data were found on the disposition of tinidazole in patients with hepatic insufficiency; therefore, use of tinidazole in patients with severe hepatic impairment (Child-Pugh class C) is not recommended. Clinical cure rates in patients with trichomoniasis, giardiasis, amebiasis, and amebic liver abscess were generally >90%. In comparative trials, tinidazole was as effective as metronidazole in the treatment of trichomoniasis and was significantly more effective than metronidazole in the treatment of giardiasis (P 1%) adverse effects included bitter taste, nausea, abdominal discomfort, anorexia, vomiting, and fatigue. The recommended dosage of tinidazole is a single dose of 2 g for trichomoniasis and giardiasis, and 2 g/d for 3 to 5 days for amebiasis. Tinidazole appears to be a promising agent for the treatment of trichomoniasis, giardiasis, amebiasis, and amebic liver abscess. Clinical studies are needed to evaluate the use of tinidazole against anaerobic bacteria and H pylori. JF - Clinical therapeutics AU - Fung, Horatio B AU - Doan, Thien-Ly AD - Medical/Surgical Patient Care Center, James J. Peters Veterans Affairs Medical Center, Bronx, New York 10468, USA. horatio.fung@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1859 EP - 1884 VL - 27 IS - 12 SN - 0149-2918, 0149-2918 KW - Antiprotozoal Agents KW - 0 KW - Tinidazole KW - 033KF7V46H KW - Index Medicus KW - Molecular Structure KW - Drug Interactions KW - Humans KW - Clinical Trials as Topic KW - Tinidazole -- pharmacology KW - Antiprotozoal Agents -- pharmacology KW - Tinidazole -- chemistry KW - Tinidazole -- economics KW - Antiprotozoal Agents -- chemistry KW - Antiprotozoal Agents -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70135081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Violence+among+individuals+in+substance+abuse+treatment%3A+the+role+of+alcohol+and+cocaine+consumption.&rft.au=Chermack%2C+Stephen+T%3BBlow%2C+Frederic+C&rft.aulast=Chermack&rft.aufirst=Stephen&rft.date=2002-03-01&rft.volume=66&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-11 N1 - Date created - 2006-03-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of repetitive nerve stimulation in the evaluation of neuromuscular junction disorders. AN - 70128298; 16457051 AB - Neuromuscular junction (NMJ) disorders are characterized by fuctuating muscle weakness. Acquired myasthenia gravis is the most common NMJ disorder with an overall prevalence in United States estimated at 60,000. Depending on the site of neuromuscular transmission failure, NMJ disorders have been classified as: (1) presynaptic (e.g., Lambert-Eaton myasthenic syndrome), (2) synaptic (e.g., cholinesterase inhibitor toxicity), and (3) post-synaptic (e.g., myasthenia gravis). Electrodiagnostic techniques used for investigation of NMJ disorders include repetitive nerve stimulation (RNS) and single fiber electromyography (SFEMG). Recent literature widely explores the use of SFEMG in the diagnosis and monitoring of myasthenia gravis, but this technique has a lesser role in the daily clinical practice outside of academic institutions. RNS is not as sensitive as SFEMG, but it is the most widely used electrodiagnostic method in the evaluation of suspected neuromuscular transmission disorders. RNS is technically easier and does not require special technical training and skill as SFEMG. Repetitive nerve stimulation was utilized first by Jolly in 1895 using an electrical drum and faradic tetanization to demonstrate a "myasthenic reaction" (weakening muscle contractions). In 1941, decremental response following the repetitive nerve stimulation was described by Harvey and Masland. While the technology has improved tremendously since then, the RNS testing is still based on supramaximal repetitive nerve stimulation and the measurement of decremental (or incremental) responses. JF - American journal of electroneurodiagnostic technology AU - Zivković, Sasa A AU - Shipe, Carol AD - Veterans Administration Pittsburgh Healthcare System and University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania 15213, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 248 EP - 261 VL - 45 IS - 4 SN - 1086-508X, 1086-508X KW - Index Medicus KW - Practice Patterns, Physicians' KW - Humans KW - Practice Guidelines as Topic KW - Electric Stimulation -- methods KW - Electromyography -- methods KW - Muscle, Skeletal -- innervation KW - Synaptic Transmission KW - Neuromuscular Junction Diseases -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70128298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+electroneurodiagnostic+technology&rft.atitle=Use+of+repetitive+nerve+stimulation+in+the+evaluation+of+neuromuscular+junction+disorders.&rft.au=Zivkovi%C4%87%2C+Sasa+A%3BShipe%2C+Carol&rft.aulast=Zivkovi%C4%87&rft.aufirst=Sasa&rft.date=2005-12-01&rft.volume=45&rft.issue=4&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=American+journal+of+electroneurodiagnostic+technology&rft.issn=1086508X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2006-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Abstinence self-efficacy and abstinence 1 year after substance use disorder treatment. AN - 69064124; 16392990 AB - To better understand the relationship between abstinence self-efficacy and treatment outcomes in substance use disorder patients, experts in the field need more information about the levels of abstinence self-efficacy most predictive of treatment outcomes. Participants (N = 2,967) from 15 residential substance use disorder treatment programs were assessed at treatment entry, discharge, and 1-year follow-up. A signal detection analysis compared the ability of different measures of self-efficacy to predict 1-year abstinence and identified the optimal cutoffs for significant predictors. The maximal level of abstinence self-efficacy (i.e., 100% confident) measured at discharge was the strongest predictor of 1-year abstinence. Treatment providers should focus on obtaining high levels of abstinence self-efficacy during treatment with the goal of achieving 100% confidence in abstinence. JF - Journal of consulting and clinical psychology AU - Ilgen, Mark AU - McKellar, John AU - Tiet, Quyen AD - Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System, CA 94025, USA. mark.ilgen@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1175 EP - 1180 VL - 73 IS - 6 SN - 0022-006X, 0022-006X KW - Index Medicus KW - ROC Curve KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Time Factors KW - Remission Induction KW - Substance-Related Disorders -- therapy KW - Self Efficacy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69064124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+consulting+and+clinical+psychology&rft.atitle=Abstinence+self-efficacy+and+abstinence+1+year+after+substance+use+disorder+treatment.&rft.au=Ilgen%2C+Mark%3BMcKellar%2C+John%3BTiet%2C+Quyen&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2005-12-01&rft.volume=73&rft.issue=6&rft.spage=1175&rft.isbn=&rft.btitle=&rft.title=Journal+of+consulting+and+clinical+psychology&rft.issn=0022006X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-14 N1 - Date created - 2006-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol-induced bone loss and deficient bone repair. AN - 69045794; 16385177 AB - Chronic consumption of excessive alcohol eventually results in an osteopenic skeleton and increased risk for osteoporosis. Alcoholics experience not only increased incidence of fractures from falls, but also delays in fracture healing compared with non-alcoholics. In this review the term "alcohol-induced bone disease" is used to refer to these skeletal abnormalities. Alcohol-induced osteopenia is distinct from osteoporoses such as postmenopausal osteoporosis and disuse osteoporosis. Gonadal insufficiency increases the rate of bone remodeling, whereas alcohol decreases this rate. Thus, histomorphometric studies show different characteristics for the bone loss that occurs in these two disease states. In particular, alcohol-induced osteopenia results mainly from decreased bone formation rather than increased bone resorption. Human, animal and cell culture studies of the effects of alcohol on bone strongly suggest alcohol has a dose-dependent toxic effect on osteoblast activity. The capacity of bone marrow stromal cells to differentiate into osteoblasts has a critical role in the cellular processes involved in the maintenance of the adult human skeleton by bone remodeling. Chronic alcohol consumption suppresses osteoblastic differentiation of bone marrow cells and promotes adipogenesis. In fracture healing, the effect of alcohol is to suppress synthesis of an ossifiable matrix, possibly due to inhibition of cell proliferation and maldifferentiation of mesenchymal cells in the repair tissue. This results in the deficient bone repair observed in animal studies, characterized by repair tissue of lower stiffness, strength and mineral content. Current knowledge of cellular effects and molecular mechanisms involved in alcohol-induced bone disease is insufficient to develop interventional strategies for its prevention and treatment. The objectives of this review are 1) to identify the characteristics of alcohol-induced bone loss and deficient bone repair as revealed in human and animal studies, 2) to determine the current understanding of the cellular effects underlying both skeletal abnormalities, and 3) to suggest directions for future studies to resolve current ambiguities regarding the cellular basis of alcohol-induced bone disease. JF - Alcoholism, clinical and experimental research AU - Chakkalakal, Dennis A AD - Orthopaedic Research Laboratory and Alcohol Research Center, Omaha Veterans Affairs Medical Center, Creighton University Biomedical Engineering Research Center and Department of Surgery, Omaha, Nebraska 68105, USA. DennisChakkalakal@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 2077 EP - 2090 VL - 29 IS - 12 SN - 0145-6008, 0145-6008 KW - Central Nervous System Depressants KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Animals KW - Humans KW - Bone Resorption -- pathology KW - Ethanol -- adverse effects KW - Central Nervous System Depressants -- adverse effects KW - Bone Diseases, Metabolic -- pathology KW - Bone Diseases, Metabolic -- chemically induced KW - Bone Development -- drug effects KW - Bone Diseases, Metabolic -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69045794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Alcohol-induced+bone+loss+and+deficient+bone+repair.&rft.au=Chakkalakal%2C+Dennis+A&rft.aulast=Chakkalakal&rft.aufirst=Dennis&rft.date=2005-12-01&rft.volume=29&rft.issue=12&rft.spage=2077&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-21 N1 - Date created - 2005-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationships between cigarette consumption and biomarkers of tobacco toxin exposure. AN - 68911770; 16365017 AB - Epidemiologic studies show a dose-response relationship between cigarettes per day and health outcomes such as heart and lung disease, and health outcomes are related to some biomarkers of tobacco exposure. The objective of this study was to examine the relationships between cigarettes per day and levels of selected biomarkers of tobacco toxin exposure: carbon monoxide (CO), metabolites of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and polycyclic aromatic hydrocarbons [total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and 1-hydroxypyrene (1-HOP), respectively], and total cotinine (cotinine plus cotinine-N-glucuronide). We did a cross-sectional analysis of merged data from (a) two clinical trials and (b) two cohorts of light smokers (total n = 400). The mean age of participants was 50.4 years and the range of cigarette consumption was 1 to 100/d; however, few subjects smoked >45 cigarettes/d (n = 12). Results show that levels of the biomarkers CO, total NNAL, and total cotinine increase with an increase in the number of cigarettes smoked per day, but not in a linear fashion. 1-HOP is a less discriminating biomarker as levels are relatively stable regardless of the number of cigarettes smoked per day. There is considerable variability in toxin measurement, especially at high levels of smoking. There was a significant correlation between cigarettes per day and total NNAL, 1-HOP, total cotinine, and CO. Total NNAL was highly significantly correlated with total cotinine and CO and also significantly correlated with 1-HOP. These findings suggest that the number of cigarettes smoked per day is not necessarily a reliable measure of toxin exposure and may underestimate tobacco toxin exposure at low levels of smoking or overestimate exposure at high levels of smoking. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Joseph, Anne M AU - Hecht, Stephen S AU - Murphy, Sharon E AU - Carmella, Steven G AU - Le, Chap T AU - Zhang, Yan AU - Han, Shaomei AU - Hatsukami, Dorothy K AD - Section of General Internal Medicine (111-0), VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA. Anne.M.Joseph@va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 2963 EP - 2968 VL - 14 IS - 12 SN - 1055-9965, 1055-9965 KW - 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol KW - 0 KW - Biomarkers KW - Nitrosamines KW - Polycyclic Aromatic Hydrocarbons KW - Pyridines KW - cotinine N-glucuronide KW - Carbon Monoxide KW - 7U1EE4V452 KW - Cotinine KW - K5161X06LL KW - Index Medicus KW - Cross-Sectional Studies KW - Randomized Controlled Trials as Topic KW - Endpoint Determination KW - Humans KW - Middle Aged KW - Urinalysis KW - Male KW - Female KW - Cotinine -- urine KW - Smoking KW - Pyridines -- urine KW - Nitrosamines -- urine KW - Cotinine -- analogs & derivatives KW - Biomarkers -- urine KW - Polycyclic Aromatic Hydrocarbons -- urine KW - Carbon Monoxide -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68911770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Relationships+between+cigarette+consumption+and+biomarkers+of+tobacco+toxin+exposure.&rft.au=Joseph%2C+Anne+M%3BHecht%2C+Stephen+S%3BMurphy%2C+Sharon+E%3BCarmella%2C+Steven+G%3BLe%2C+Chap+T%3BZhang%2C+Yan%3BHan%2C+Shaomei%3BHatsukami%2C+Dorothy+K&rft.aulast=Joseph&rft.aufirst=Anne&rft.date=2005-12-01&rft.volume=14&rft.issue=12&rft.spage=2963&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2005-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Heat decreases formoterol delivery. AN - 68900964; 16354878 AB - Based on anecdotal reports of formoterol aggregating in mailboxes in the summer in Arizona, we examined the effect of heat on formoterol as well as on drug delivery. Formoterol capsules in original blister packaging were heated to 40 to 70 degrees C (104 to 158 degrees F) for 3 h and at 70 degrees C (158 degrees F) for 15 to 180 min. Capsules were removed from packaging, and a vacuum setup was used to dispense the formoterol into a filter using the device provided by the manufacturer. The weights of the capsule predispensation and postdispensation were measured to calculate drug delivery. Measurements were compared to those of capsules not exposed to heat. For comparison, tiotropium and a combination of fluticasone propionate and salmeterol (Advair; GlaxoSmithKline; Research Triangle Park, NC) were similarly tested. Visual inspection of the heated capsules revealed gross distortion as well as visible clumping of formoterol at the higher temperatures. The mean (+/- SEM) change in the weights of capsules that underwent heating were significantly less than those obtained from capsules that had not been heated (mean change after heating for 3 h at 70 degrees C, 2.3 +/- 0.7 vs 24.7 +/- 0.6 mg, respectively; p < 0.001), indicating decreased formoterol delivery. Heat produced a dose-responsive and time-responsive decrease in formoterol delivery. One of six capsules that were subjected to temperatures as low as 40 degrees C (104 degrees F) for 3 h had decreased delivery, and three of six capsules subjected to a temperature of 70 degrees C (158 degrees F) for times as short as 30 min decreased delivery. In contrast, neither tiotropium nor fluticasone propionate/salmeterol delivery was decreased by heating for up to 3 h at 70 degrees C (158 degrees F). Thermometers placed in mailboxes or in car windows in mid-summer in Arizona (approximate outside temperature, 110 degrees F [43 degrees C]) exceeded 70 degrees C (158 degrees F). These data demonstrate that the exposure of formoterol to heat decreases drug delivery and that caution should be used when mailing, transporting or storing formoterol. JF - Chest AU - Robbins, Richard A AU - Thomas, Allen R AU - Proctor, Lynda M AU - Hoyt, Jeffrey C AU - Hayden, John M AD - Pulmonary and Critical Care Medicine, Carl T. Hayden VA Medical Center, 650 East Indian School Rd, Phoenix, AZ 85012, USA. Richard.Robbins2@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 4036 EP - 4040 VL - 128 IS - 6 SN - 0012-3692, 0012-3692 KW - Bronchodilator Agents KW - 0 KW - Ethanolamines KW - Formoterol Fumarate KW - W34SHF8J2K KW - Abridged Index Medicus KW - Index Medicus KW - Sensitivity and Specificity KW - Drug Delivery Systems KW - Asthma -- drug therapy KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Pulmonary Disease, Chronic Obstructive -- drug therapy KW - Administration, Inhalation KW - Ethanolamines -- pharmacology KW - Bronchodilator Agents -- pharmacology KW - Bronchodilator Agents -- administration & dosage KW - Ethanolamines -- administration & dosage KW - Hot Temperature -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68900964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Heat+decreases+formoterol+delivery.&rft.au=Robbins%2C+Richard+A%3BThomas%2C+Allen+R%3BProctor%2C+Lynda+M%3BHoyt%2C+Jeffrey+C%3BHayden%2C+John+M&rft.aulast=Robbins&rft.aufirst=Richard&rft.date=2005-12-01&rft.volume=128&rft.issue=6&rft.spage=4036&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-17 N1 - Date created - 2005-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic hepatitis C in patients with HIV/AIDS: a new challenge in antiviral therapy. AN - 68887016; 16308419 AB - HIV-infected patients are living longer since the introduction of highly active antiretroviral therapy. However, coinfection with the hepatitis C virus (HCV) leads to increased morbidity from liver disease and higher overall mortality. The prevalence of chronic hepatitis C among patients with HIV/AIDS ranges from 7% (sexual transmission of HIV) to >90% (injection drug use). Uncontrolled HIV infection seems to accelerate the progression of HCV-induced liver fibrosis. Forty-eight weeks of combination therapy with pegylated interferon alpha (2a or 2b) plus ribavirin achieves a sustained viral response in coinfected individuals in up to 38% with HCV genotype 1 and up to 73% with genotypes 2 or 3. The safety profile of this treatment is similar to therapy in HCV-monoinfected patients with influenza-like symptoms, cytopenia and neuropsychiatric symptoms dominating. However, HIV/HCV-coinfected patients who also take zidovudine develop more profound anaemia than those on other HIV nucleoside analogue therapy. Didanosine and stavudine are associated with rare but serious mitochondrial toxicity, such as pancreatitis or lactic acidosis. It does not appear that the addition of ribavirin increases that risk. There is currently no evidence that in HIV/HCV coinfection one pegylated interferon product is superior to the other. Contrary to common perception, it is also unproven that HIV/HCV-coinfected patients respond less well to therapy with peginterferon alpha plus ribavirin than HCV-monoinfected patients. Given the safety and efficacy of combination therapy with peginterferon plus ribavirin and the deleterious effects of chronic hepatitis C, all HIV/HCV-coinfected patients should be evaluated for therapy. JF - The Journal of antimicrobial chemotherapy AU - Bräu, Norbert AD - Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY 10468, USA. norbert.brau@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 991 EP - 995 VL - 56 IS - 6 SN - 0305-7453, 0305-7453 KW - Anti-HIV Agents KW - 0 KW - Antiviral Agents KW - Interferon-alpha KW - Recombinant Proteins KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2a KW - 47RRR83SK7 KW - Ribavirin KW - 49717AWG6K KW - peginterferon alfa-2a KW - Q46947FE7K KW - Index Medicus KW - Ribavirin -- therapeutic use KW - Drug Interactions KW - Interferon-alpha -- therapeutic use KW - Randomized Controlled Trials as Topic KW - Polyethylene Glycols -- therapeutic use KW - Humans KW - Anti-HIV Agents -- adverse effects KW - Polyethylene Glycols -- adverse effects KW - Ribavirin -- adverse effects KW - Drug Therapy, Combination KW - Interferon-alpha -- adverse effects KW - Anti-HIV Agents -- therapeutic use KW - Antiretroviral Therapy, Highly Active KW - Antiviral Agents -- therapeutic use KW - HIV Infections -- complications KW - Hepatitis C, Chronic -- drug therapy KW - Hepatitis C, Chronic -- complications KW - HIV Infections -- drug therapy KW - Antiviral Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68887016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+antimicrobial+chemotherapy&rft.atitle=Chronic+hepatitis+C+in+patients+with+HIV%2FAIDS%3A+a+new+challenge+in+antiviral+therapy.&rft.au=Br%C3%A4u%2C+Norbert&rft.aulast=Br%C3%A4u&rft.aufirst=Norbert&rft.date=2005-12-01&rft.volume=56&rft.issue=6&rft.spage=991&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+antimicrobial+chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-21 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of childhood abuse on the course of bipolar disorder: a replication study in U.S. veterans. AN - 68882960; 16213029 AB - The association between early childhood abuse and the course of illness, including psychiatric comorbidities, in adults with bipolar disorder has not been examined in a predominantly male or veteran population. As part of the VA Cooperative Study 430, "Reducing the Efficacy-Effectiveness Gap in Bipolar Disorder," 330 veterans (91% male) with bipolar I or II disorder who were enrolled in a 3-year prospective study were examined for baseline data obtained at study entry. Diagnoses were determined by the use of the SCID. A semistructured interview designed to elicit data about exposure to childhood physical, sexual, or combined abuse was conducted as part of baseline demographic and clinical information. Other reports from this data set have not addressed the issues of childhood adversity. Childhood abuse was reported by 48.3% of the subjects (47.3% of men). Any abuse (AA) was reported by 48.3%; sexual abuse without physical abuse (SA) was reported by 8%, physical abuse without sexual abuse (PA) by 20.7%, and both types of abuse (combined abuse, CA) by 18.7% of the male subjects. Female veterans reported more SA (27%) and less PA (6.7%). AA subjects were more likely to have current PTSD and lifetime diagnoses of panic disorder and alcohol use disorders. CA was associated with lower SF-36 Mental scores, higher likelihood of current PTSD and lifetime diagnoses of alcohol use disorders, as well as more lifetime episodes of major depression and higher likelihood of at least one suicide attempt. Younger age at study entry was associated with AA and PA. Potential limitations include generalizability beyond the male, veteran population of patients with bipolar disorder and the methodology used to elicit abuse histories. Similar to studies of predominantly female nonveteran samples, this study extends the finding that a history of childhood abuse acts as a disease course modifier in male veterans with bipolar disorder. Clinicians should routinely seek information regarding abuse and be aware that these patients may be more difficult to treat than bipolar patients who have no abuse histories. JF - Journal of affective disorders AU - Brown, George R AU - McBride, Linda AU - Bauer, Mark S AU - Williford, William O AU - Cooperative Studies Program 430 Study Team AD - Mountain Home VAMC and East Tennessee State University, Johnson City, TN, USA. George.brown@med.va.gov ; Cooperative Studies Program 430 Study Team Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 57 EP - 67 VL - 89 IS - 1-3 SN - 0165-0327, 0165-0327 KW - Index Medicus KW - United States KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Sex Factors KW - Reproducibility of Results KW - Stress Disorders, Post-Traumatic -- psychology KW - Humans KW - Child KW - Depressive Disorder, Major -- epidemiology KW - Alcoholism -- psychology KW - Likelihood Functions KW - Comorbidity KW - Health Services Accessibility -- statistics & numerical data KW - Panic Disorder -- psychology KW - Prospective Studies KW - Panic Disorder -- epidemiology KW - Alcoholism -- epidemiology KW - Depressive Disorder, Major -- psychology KW - Adult KW - Middle Aged KW - Statistics as Topic KW - Female KW - Male KW - Child Abuse, Sexual -- psychology KW - Child Abuse -- psychology KW - Bipolar Disorder -- epidemiology KW - Veterans -- statistics & numerical data KW - Child Abuse -- statistics & numerical data KW - Veterans -- psychology KW - Child Abuse, Sexual -- statistics & numerical data KW - Bipolar Disorder -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68882960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+affective+disorders&rft.atitle=Impact+of+childhood+abuse+on+the+course+of+bipolar+disorder%3A+a+replication+study+in+U.S.+veterans.&rft.au=Brown%2C+George+R%3BMcBride%2C+Linda%3BBauer%2C+Mark+S%3BWilliford%2C+William+O%3BCooperative+Studies+Program+430+Study+Team&rft.aulast=Brown&rft.aufirst=George&rft.date=2005-12-01&rft.volume=89&rft.issue=1-3&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Journal+of+affective+disorders&rft.issn=01650327&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-03 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dextromethorphan psychosis, dependence and physical withdrawal. AN - 68845841; 16318953 AB - As part of a synthesis of evidence regarding the abuse and addiction liability of dextromethorphan (DM), an over-the-counter cough medicine available in over 140 preparations, an uncommonly published case of dextromethorphan dependence (addiction) is described, with specific, rarely published complications. The individual was interviewed and several medical databases were also reviewed (Medline, 1966-present; PubMed) for all content relating to the Keywords: dextromethorphan, abuse, dependence, cough medicine, addiction, withdrawal, psychosis. The patient evidenced history suggesting substance dependence, substance-induced psychosis and substance withdrawal in relation to DM. A literature review revealed that DM has specific serotonergic and sigma-1 opioidergic properties. Dextrorphan (DOR), the active metabolite of DM, has similar properties; however, DOR is a weaker sigma opioid receptor agonist, and a stronger NMDA receptor antagonist. DM and DOR display specific biological features of addiction, and are capable of inducing specific psychiatric sequelae. A specific, reproducible toxidrome with significant psychiatric effects occurred, when DM was abused at greater than indicated doses, with more profound and potentially life-threatening effects at even higher doses. DM withdrawal appears evident. DM's active metabolite, DOR, has pharmacodynamic properties and intoxication effects similar to dissociatives, and may be more responsible for the dissociative effect that this DM abuser sought. However, it is this same metabolite that may be fraught with the potentially life-threatening psychoses and dissociative-induced accidents, as well as addiction. While DM has been hypothesized as the most commonly abused dissociative, health-care providers seem largely unaware of its toxidrome and addiction liability. JF - Addiction biology AU - Miller, Shannon C AD - Addiction Services, Veterans Administration Medical Center and Associate Professor, Department of Psychiatry, Wright State University School of Medicine, Dayton, OH 45428, USA. shannon.miller2@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 325 EP - 327 VL - 10 IS - 4 SN - 1355-6215, 1355-6215 KW - Analgesics, Opioid KW - 0 KW - Antitussive Agents KW - Nonprescription Drugs KW - Receptors, sigma KW - Dextrorphan KW - 04B7QNO9WS KW - Dextromethorphan KW - 7355X3ROTS KW - Index Medicus KW - Drug Tolerance KW - Hallucinations -- chemically induced KW - Dose-Response Relationship, Drug KW - Humans KW - Dextrorphan -- toxicity KW - Adult KW - Receptors, sigma -- agonists KW - Delusions -- chemically induced KW - Recurrence KW - Female KW - Substance Withdrawal Syndrome -- etiology KW - Dextromethorphan -- toxicity KW - Substance Withdrawal Syndrome -- rehabilitation KW - Antitussive Agents -- toxicity KW - Substance-Related Disorders -- etiology KW - Nonprescription Drugs -- toxicity KW - Psychoses, Substance-Induced -- etiology KW - Substance-Related Disorders -- rehabilitation KW - Psychoses, Substance-Induced -- rehabilitation KW - Analgesics, Opioid -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68845841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+biology&rft.atitle=Dextromethorphan+psychosis%2C+dependence+and+physical+withdrawal.&rft.au=Miller%2C+Shannon+C&rft.aulast=Miller&rft.aufirst=Shannon&rft.date=2005-12-01&rft.volume=10&rft.issue=4&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Addiction+biology&rft.issn=13556215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-03 N1 - Date created - 2005-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Continuity of care practices and substance use disorder patients' engagement in continuing care. AN - 68817374; 16299435 AB - Substance use disorder (SUD) patients who engage in more continuing care have better outcomes, but information on practices associated with greater patient engagement and retention in continuing care remains elusive. The objectives of this study were to determine if staff's continuity of care practices predict patients' engagement in continuing care in the 6 months after discharge from intensive SUD treatment and to determine if the impact of continuity of care practices on patients' engagement in continuing care differs for patients treated in inpatient/residential versus outpatient programs. Staff in 28 Veterans Affairs (VA) intensive SUD treatment programs with varying continuity of care practices provided data on 878 patients' alcohol and drug problems at treatment entry. At discharge, staff provided data on patients' motivation, treatment intensity, and on the continuity of care practices they used with each patient. VA administrative databases supplied data on patients' subsequent engagement in continuing care. Mixed-effects modeling was used to examine predictors of patients' engagement in care. Patients in outpatient programs who received more continuity of care engaged in continuing care significantly longer. More highly motivated outpatients, those with fewer alcohol problems at treatment entry, and patients who used VA services in the year before treatment also remained in continuing care longer. These findings did not hold for patients treated in inpatient/residential programs. Continuity of care practices predicted engagement in continuing care only for patients treated in outpatient SUD programs. More research is needed to identify effective continuity of care practices for patients treated in inpatient/residential programs. JF - Medical care AU - Schaefer, Jeanne A AU - Ingudomnukul, Erin AU - Harris, Alex H S AU - Cronkite, Ruth C AD - Center for Health Care Evaluation, Department of Veterans Affairs Health Care System, Palo Alto, CA, USA. Jeanne.Schaefer@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1234 EP - 1241 VL - 43 IS - 12 SN - 0025-7079, 0025-7079 KW - Index Medicus KW - United States KW - Socioeconomic Factors KW - Outpatients KW - Substance Abuse Treatment Centers -- organization & administration KW - Motivation KW - United States Department of Veterans Affairs KW - Humans KW - Health Services Research KW - Alcohol Drinking -- adverse effects KW - Middle Aged KW - Inpatients KW - Substance-Related Disorders -- therapy KW - Continuity of Patient Care -- organization & administration KW - Patient Dropouts -- psychology KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68817374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=Continuity+of+care+practices+and+substance+use+disorder+patients%27+engagement+in+continuing+care.&rft.au=Schaefer%2C+Jeanne+A%3BIngudomnukul%2C+Erin%3BHarris%2C+Alex+H+S%3BCronkite%2C+Ruth+C&rft.aulast=Schaefer&rft.aufirst=Jeanne&rft.date=2005-12-01&rft.volume=43&rft.issue=12&rft.spage=1234&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=00257079&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-21 N1 - Date created - 2005-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms. AN - 68808587; 15907335 AB - Arsenic is a naturally occurring, worldwide contaminant implicated in numerous pathological conditions in humans, including cancer and several forms of liver disease. One of the contributing factors to these disorders may be the alteration of cytochrome P450 (CYP) levels by arsenic. In rat and human hepatocyte cultures, arsenic, in the form of arsenite, decreases the induction of several CYPs. The present study investigated whether arsenite utilizes transcriptional or post-transcriptional mechanisms to decrease CYP3A23 in primary cultures of rat hepatocytes. In these cultures, a 6-h treatment with 5 microM arsenite abolished dexamethasone (DEX)-mediated induction of CYP3A23 protein and activity, but did not inhibit general protein synthesis. However, arsenite treatment only reduced DEX-induced levels of CYP3A23 mRNA by 30%. The effects of arsenite on CYP3A23 transcription were examined using a luciferase reporter construct containing 1.4 kb of the CYP3A23 promoter. Arsenite caused a 30% decrease in DEX-induced luciferase expression of this reporter. Since arsenite abolished induction of CYP3A23 protein, but caused only a small decrease in CYP3A23 mRNA, the effects of arsenite on translation of CYP3A23 mRNA were investigated. Polysomal distribution analysis showed that arsenite decreased translation by decreasing the DEX-mediated increase in CYP3A23 mRNA association with polyribosomes. Arsenite did not decrease intracellular glutathione or increase lipid peroxidation, suggesting that the effect of arsenite on CYP3A23 does not involve oxidative stress. Overall, the results suggest that low-level arsenite decreases both transcription and translation of CYP3A23 in primary rat hepatocyte cultures. JF - Toxicology and applied pharmacology AU - Noreault, Trisha L AU - Jacobs, Judith M AU - Nichols, Ralph C AU - Trask, Heidi W AU - Wrighton, Steven A AU - Sinclair, Peter R AU - Evans, Ronald M AU - Sinclair, Jacqueline F AD - Veterans Administration Medical Center, White River Junction, VT 05009, USA. Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 174 EP - 182 VL - 209 IS - 2 SN - 0041-008X, 0041-008X KW - Arsenites KW - 0 KW - RNA, Messenger KW - Dexamethasone KW - 7S5I7G3JQL KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP3A23 protein, rat KW - Cytochrome P-450 CYP3A KW - arsenite KW - N5509X556J KW - Index Medicus KW - Animals KW - Immunoblotting KW - Hepatocytes -- drug effects KW - Dexamethasone -- pharmacology KW - Polyribosomes -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Hepatocytes -- enzymology KW - RNA, Messenger -- biosynthesis KW - Rats KW - Rats, Inbred F344 KW - Enzyme Induction -- drug effects KW - Polyribosomes -- enzymology KW - Male KW - Hepatocytes -- metabolism KW - Protein Biosynthesis -- drug effects KW - Liver -- enzymology KW - Transcription, Genetic -- drug effects KW - Liver -- drug effects KW - Aryl Hydrocarbon Hydroxylases -- antagonists & inhibitors KW - Arsenites -- toxicity KW - Liver -- metabolism KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Aryl Hydrocarbon Hydroxylases -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68808587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Arsenite+decreases+CYP3A23+induction+in+cultured+rat+hepatocytes+by+transcriptional+and+translational+mechanisms.&rft.au=Noreault%2C+Trisha+L%3BJacobs%2C+Judith+M%3BNichols%2C+Ralph+C%3BTrask%2C+Heidi+W%3BWrighton%2C+Steven+A%3BSinclair%2C+Peter+R%3BEvans%2C+Ronald+M%3BSinclair%2C+Jacqueline+F&rft.aulast=Noreault&rft.aufirst=Trisha&rft.date=2005-12-01&rft.volume=209&rft.issue=2&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-03 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differences among sexually abused and nonabused youth living with HIV. AN - 68729280; 16246916 AB - Risk behaviors were compared between sexually abused and nonabused youth living with HIV (YLH). Abused YLH were significantly more likely to have attempted suicide, to have been admitted into an alcohol and/or drug treatment program, and to have engaged in crack cocaine use than were nonabused YLH and had a greater number of sexual partners. A significantly higher proportion of abused YLH had been incarcerated in contrast to nonabused youth. There were also significantly greater conduct problems among abused YLH. Finally, abused YLH had significantly higher scores on positive action and social-support coping styles than nonabused youth. Consistent with previous research, abused youth are at higher risk for a variety of negative outcomes and are also similar in many respects to sexually abused youth who are not HIV-positive. The high frequencies of two positive styles of coping among abused YLH were also observed. JF - Journal of interpersonal violence AU - Anaya, Henry D AU - Swendeman, Dallas AU - Rotheram-Borus, Mary Jane AD - U.S. Department of Veterans Affairs. hanaya@ucla.edu Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1547 EP - 1559 VL - 20 IS - 12 SN - 0886-2605, 0886-2605 KW - Index Medicus KW - Risk-Taking KW - Adaptation, Psychological KW - Humans KW - Adult KW - Psychology, Adolescent KW - Substance-Related Disorders -- psychology KW - Adolescent KW - United States -- epidemiology KW - Sexual Behavior -- psychology KW - Male KW - Female KW - Substance-Related Disorders -- epidemiology KW - Child Abuse, Sexual -- psychology KW - Child Abuse, Sexual -- rehabilitation KW - Adolescent Behavior -- psychology KW - Health Behavior KW - Child Abuse, Sexual -- statistics & numerical data KW - HIV Infections -- psychology KW - HIV Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68729280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+interpersonal+violence&rft.atitle=Differences+among+sexually+abused+and+nonabused+youth+living+with+HIV.&rft.au=Anaya%2C+Henry+D%3BSwendeman%2C+Dallas%3BRotheram-Borus%2C+Mary+Jane&rft.aulast=Anaya&rft.aufirst=Henry&rft.date=2005-12-01&rft.volume=20&rft.issue=12&rft.spage=1547&rft.isbn=&rft.btitle=&rft.title=Journal+of+interpersonal+violence&rft.issn=08862605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-09 N1 - Date created - 2005-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An Application of Rasch Analysis to the Measurement of Communicative Functioning AN - 57069058; 200617768 AB - Purpose: The purposes of this investigation were to examine the construct dimensionality & range of ability effectively measured by 28 assessment items obtained from 3 different patient-reported scales of communicative functioning, & to provide a demonstration of how the Rasch approach to measurement may contribute to the definition of latent constructs & the development of instruments to measure them. Method: Item responses obtained from 421 stroke survivors with & without communication disorders were examined using the Rasch partial credit model. The dimensionality of the item pool was evaluated by (a) examining correlations of Rasch person ability scores obtained separately from each of the 3 scales, (b) iteratively excluding items exceeding mean square model fit criteria, & (c) using principal-components analysis of Rasch model residuals. The range of ability effectively measured by the item pool was examined by comparing item difficulty & category threshold calibrations to the distribution of person ability scores & by plotting the modeled standard error of person ability estimates as a function of person ability level. Results: The results indicate that most assessment items fit a unidimensional measurement model, with the notable exception of items relating to the use of written communication. The results also suggest that the range of ability that could be reliably measured by the current item pool was restricted relative to the range of ability observed in the patient sample. Conclusions: It is concluded that (a) a mature understanding of communicative functioning as a measurement construct will require further research, (b) patients with stroke-related communication disorders will be better served by the development of instruments measuring a wider range of communicative functioning ability, & (c) the theoretical & methodological tools provided by the Rasch family of measurement models may be productively applied to these efforts. Tables, Figures, References. Adapted from the source document. JF - Journal of Speech, Language, and Hearing Research AU - Doyle, Patrick J AU - Hula, William D AU - McNeil, Malcolm R AU - Mikolic, Joseph M AU - Matthews, Christine AD - VA Pittsburgh Healthcare Systems, PA patrick.doyle@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1412 EP - 1428 PB - American Speech-Language-Hearing Association, Rockville MD VL - 48 IS - 6 SN - 1092-4388, 1092-4388 KW - communicative functioning, outcomes, Rasch analysis, measurement KW - Evaluation KW - Rasch model KW - Communication skills KW - Measures KW - Communication disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57069058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=An+Application+of+Rasch+Analysis+to+the+Measurement+of+Communicative+Functioning&rft.au=Doyle%2C+Patrick+J%3BHula%2C+William+D%3BMcNeil%2C+Malcolm+R%3BMikolic%2C+Joseph+M%3BMatthews%2C+Christine&rft.aulast=Doyle&rft.aufirst=Patrick&rft.date=2005-12-01&rft.volume=48&rft.issue=6&rft.spage=1412&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/10.1044%2F1092-4388%282005%2F098%29 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-29 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Communication skills; Measures; Evaluation; Rasch model; Communication disorders DO - http://dx.doi.org/10.1044/1092-4388(2005/098) ER - TY - JOUR T1 - Perceptions and Attitudes about HFE Genotyping Among College-Age Adults AN - 20832148; 7024093 AB - Purpose: Examine young adults' attitudes about HFE genotyping. Methods: 121 college students read about hemochromatosis, transferrin saturation measurement (iron test), and HFE genotyping. Interest in testing and knowledge and attitudes about genetic testing were assessed. Participants were randomly assigned to predict either their response to a positive HFE genotype (genotype group) or a positive iron test (phenotype group). Results: 71% preferred the iron test, but most would undergo either test. Learning risk and early detection/prevention were the most commonly perceived benefits; limited information about health and negative emotional consequences were the most commonly perceived disadvantages. The genotype and phenotype groups did not differ in expected worry, perceived severity, perceived risk, and preventability of organ damage. After reading the description provided, participants answered 78% of knowledge questions correctly. Conclusions: Young adults view HFE genotyping positively and report few disadvantages, but prefer the iron test for its information about current health. They appear to be receptive to public health screening for hemochromatosis. JF - Journal of Genetic Counseling AU - Hicken, Bret L AU - Foshee, Aimee AU - Tucker, Diane C AD - Salt Lake City VAMC, 500 Foothill Dr, Salt Lake City, UT 84148, bret.hicken@med.va.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 465 EP - 472 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 14 IS - 6 SN - 1059-7700, 1059-7700 KW - hemochromatosis KW - Genetics Abstracts; Risk Abstracts KW - Emotions KW - Learning KW - Genotyping KW - Genotypes KW - Public health KW - Transferrin KW - Perception KW - prevention KW - Genetic screening KW - Hemochromatosis KW - Language KW - Iron KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20832148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Genetic+Counseling&rft.atitle=Perceptions+and+Attitudes+about+HFE+Genotyping+Among+College-Age+Adults&rft.au=Hicken%2C+Bret+L%3BFoshee%2C+Aimee%3BTucker%2C+Diane+C&rft.aulast=Hicken&rft.aufirst=Bret&rft.date=2005-12-01&rft.volume=14&rft.issue=6&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Journal+of+Genetic+Counseling&rft.issn=10597700&rft_id=info:doi/10.1007%2Fs10897-005-4718-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Emotions; Transferrin; Learning; Perception; Genotyping; Hemochromatosis; Language; Genotypes; Iron; Public health; prevention; Genetic screening DO - http://dx.doi.org/10.1007/s10897-005-4718-y ER - TY - CPAPER T1 - Replication of Association of IL-1 Gene Cluster Members with Ankylosing Spondylitis (AS) in Taiwanese Chinese T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39836782; 4104107 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Timms, Andrew E AU - Chou, Chung-Tei AU - Wei, James C.C. AU - Tsai, Wen C AU - Wordsworth, B.Paul AU - Brown, Matthew A Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Replication KW - Interleukin 1 KW - Ankylosing spondylitis KW - Gene clusters KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39836782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Replication+of+Association+of+IL-1+Gene+Cluster+Members+with+Ankylosing+Spondylitis+%28AS%29+in+Taiwanese+Chinese&rft.au=Timms%2C+Andrew+E%3BChou%2C+Chung-Tei%3BWei%2C+James+C.C.%3BTsai%2C+Wen+C%3BWordsworth%2C+B.Paul%3BBrown%2C+Matthew+A&rft.aulast=Timms&rft.aufirst=Andrew&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - P44 Transgenic Mice Have an Early and Dramatic Increase in Ab Levels in the Brain: A Possible Role of IGF - 1 Signaling in the Regulation of Ab Production During Aging T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39895461; 4121174 JF - 35th Annual Meeting of the Society for Neuroscience AU - Costantini, C AU - Scrable, H AU - Puglielli, L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Aging KW - Mice KW - Brain KW - Antibodies KW - Signal transduction KW - Insulin-like growth factors KW - Transgenic mice KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39895461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=P44+Transgenic+Mice+Have+an+Early+and+Dramatic+Increase+in+Ab+Levels+in+the+Brain%3A+A+Possible+Role+of+IGF+-+1+Signaling+in+the+Regulation+of+Ab+Production+During+Aging&rft.au=Costantini%2C+C%3BScrable%2C+H%3BPuglielli%2C+L&rft.aulast=Costantini&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Discriminating Patients with Frontal-Lobe Epilepsy and Temporal-Lobe Epilepsy: Utility of a Multilevel Design Fluency Test AN - 85623886; 200609041 AB - Patients with frontal-lobe epilepsy (FLE) or temporal-lobe epilepsy (TLE) & matched control participants were given a design fluency test that assessed nonverbal fluency & switching ability. Patients with FLE generated fewer designs in the switching condition relative to the TLE patients & controls, whereas group differences did not emerge in the basic fluency conditions. When the side of the seizure focus & the presence or absence of a structural lesion were considered in patients with FLE, only those with left-lesional FLE generated fewer designs than controls did in the switching condition. Furthermore, patients with left-lesional & nonlesional FLE produced a greater proportion of set-loss errors than did controls. These results indicate that patients with FLE are impaired when they must simultaneously generate new designs & engage in cognitive switching; however, the pattern of impairment may depend on the side of the seizure focus & the presence of a structural lesion. 2 Tables, 3 Figures, 31 References. [Copyright 2005 The American Psychological Association.] JF - Neuropsychology AU - McDonald, Carrie R AU - Delis, Dean C AU - Norman, Marc A AU - Tecoma, Evelyn S AU - Iragui, Vicente J AD - Delis Lab, Veterans Administration San Diego Healthcare System, La Jolla, CA camcdonald@ucsd.edu Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 806 EP - 813 VL - 19 IS - 6 SN - 0894-4105, 0894-4105 KW - Linguistic Competence (47400) KW - Brain Damage (09400) KW - Executive Function (23470) KW - Nervous System Disorders (57100) KW - Neurolinguistics (57250) KW - Measures (Instruments) (52300) KW - Fluency (24910) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85623886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychology&rft.atitle=Discriminating+Patients+with+Frontal-Lobe+Epilepsy+and+Temporal-Lobe+Epilepsy%3A+Utility+of+a+Multilevel+Design+Fluency+Test&rft.au=McDonald%2C+Carrie+R%3BDelis%2C+Dean+C%3BNorman%2C+Marc+A%3BTecoma%2C+Evelyn+S%3BIragui%2C+Vicente+J&rft.aulast=McDonald&rft.aufirst=Carrie&rft.date=2005-11-01&rft.volume=19&rft.issue=6&rft.spage=806&rft.isbn=&rft.btitle=&rft.title=Neuropsychology&rft.issn=08944105&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2006-08-01 N1 - Last updated - 2016-09-27 N1 - CODEN - NEUPEG N1 - SubjectsTermNotLitGenreText - Nervous System Disorders (57100); Brain Damage (09400); Fluency (24910); Neurolinguistics (57250); Linguistic Competence (47400); Executive Function (23470); Measures (Instruments) (52300) ER - TY - JOUR T1 - When hearing aids go bad: an FM success story. AN - 85396268; pmid-16515133 AB - Both clinical and research findings support the effectiveness of frequency-modulated (FM) technology among individuals who continue to encounter significant communication problems despite the use of conventional hearing instruments. The use rate of FM devices throughout the nation, however, remains disappointingly low. The authors present a case of a longtime hearing aid user whose hearing aids provided decreasing benefit as his hearing impairment increased to the extent that cochlear implantation was considered. Through the establishment of patient-specific treatment goals, the provision of appropriate FM technology as verified through real-ear measurements, and careful and deliberate counseling and follow-up, this patient was able to realize significant communication benefits as reported through several self-assessment measures. The cost-benefit implications of FM technology versus cochlear implantation are discussed. JF - Journal of the American Academy of Audiology AU - McArdle, Rachel AU - Abrams, Harvey B AU - Chisolm, Theresa Hnath AD - Bay Pines VA Healthcare System, Audiology (126), P.O. Box 5005, Bay Pines, FL 33744, USA. Rachel.mcardle@med.va.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 809 EP - 821 VL - 16 IS - 10 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Cost-Benefit Analysis KW - Equipment Design KW - Follow-Up Studies KW - Hearing Aids: economics KW - Hearing Aids: psychology KW - Hearing Loss: economics KW - *Hearing Loss: rehabilitation KW - Humans KW - Male KW - Patient Education as Topic KW - Patient Satisfaction KW - Questionnaires KW - Radio: instrumentation KW - Radio Waves: classification KW - *Speech Perception KW - Treatment Outcome KW - Veterans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=When+hearing+aids+go+bad%3A+an+FM+success+story.&rft.au=McArdle%2C+Rachel%3BAbrams%2C+Harvey+B%3BChisolm%2C+Theresa+Hnath&rft.aulast=McArdle&rft.aufirst=Rachel&rft.date=2005-11-01&rft.volume=16&rft.issue=10&rft.spage=809&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Use of 35 words for evaluation of hearing loss in signal-to-babble ratio: A clinic protocol. AN - 70156011; 16680621 AB - Data from earlier studies that presented 70 words at 24 to 0 dB signal-to-babble (S/B) ratios indicated that most young listeners with normal hearing required 0 to 6 dB S/B ratios to attain 50% correct word recognition. Older listeners with hearing loss often required a >12 dB S/B ratio to attain 50% correct word recognition. In our study, we converted the Words in Noise test from one 70-word list into two 35-word lists for quicker administration by clinicians. Using baseline data from previous studies, we used two strategies to randomize the 35-word lists: based on recognition performance at each S/B ratio and based on recognition performance only. With the first randomization strategy, the 50% correct word-recognition points on the two lists differed by 0.5 dB for 72 listeners with hearing loss. With the second randomization strategy, 48 listeners with hearing loss performed identically on the two lists. JF - Journal of rehabilitation research and development AU - Wilson, Richard H AU - Burks, Christopher A AD - James H. Quillen Department of Veterans Affairs Medical Center, Mountain Home, TN, USA. richard.wilson2@med.va.gov PY - 2005 SP - 839 EP - 852 VL - 42 IS - 6 KW - Index Medicus KW - Severity of Illness Index KW - Reference Values KW - Age Factors KW - Analysis of Variance KW - Auditory Threshold KW - Humans KW - Vocabulary KW - Aged KW - Verbal Behavior -- physiology KW - Aging -- physiology KW - Speech Perception KW - Aged, 80 and over KW - Audiometry, Speech -- methods KW - Adult KW - Noise KW - Middle Aged KW - Female KW - Male KW - Hearing Loss -- diagnosis KW - Speech Reception Threshold Test -- instrumentation KW - Auditory Perception -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70156011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+rehabilitation+research+and+development&rft.atitle=Use+of+35+words+for+evaluation+of+hearing+loss+in+signal-to-babble+ratio%3A+A+clinic+protocol.&rft.au=Wilson%2C+Richard+H%3BBurks%2C+Christopher+A&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2005-11-01&rft.volume=42&rft.issue=6&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=Journal+of+rehabilitation+research+and+development&rft.issn=1938-1352&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-21 N1 - Date created - 2006-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sequencing the lifetime onset of alcohol-related symptoms in older adults: is there evidence of disease progression? AN - 70121010; 16459937 AB - The purpose of this study was to evaluate evidence of orderly symptom progression in alcohol-use disorders (disease-progression model). A sample of community-residing older problem drinkers provided information about their life history of drinking, including the age at which they had experienced alcohol-related symptoms that correspond to criteria for alcohol abuse and dependence. Symptom sets and possible sequences were formulated separately for women and men, based on the average number of years from drinking initiation to symptom onset and on symptom prevalence. We assessed how well the ordering of symptoms experienced by individual respondents matched the sequences derived with these group-level measures; we also assessed whether individuals progress from alcohol abuse to dependence as is implied in some conceptualizations of alcohol-use disorders. Half or more of these older adults experienced symptom onset in an order that was inconsistent with the possible symptom sequences derived from group-level analysis (e.g., reversals from the expected order or concurrent onset of symptoms expected to occur sequentially). Similarly, alcohol abuse did not appear to be a precursor to the development of alcohol dependence in individual patterns of symptom onset. Although group-level results based on the number of years from drinking initiation to symptom onset or on symptom prevalence may seem to point to orderly progression in the development of alcohol-related symptoms, these group-level results do not capture individual experiences very well. In this community-residing sample of problem drinkers, most of whom had never sought treatment, there was marked variability in the course of symptom development, which raises questions about the utility of a disease-progression model. JF - Journal of studies on alcohol AU - Lemke, Sonne AU - Schutte, Kathleen K AU - Brennan, Penny L AU - Moos, Rudolf H AD - Department of Veterans Affairs, Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System, 795 Willow Road, Menlo Park, California 94025, USA. Sonne.Lemke@va.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 756 EP - 765 VL - 66 IS - 6 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Severity of Illness Index KW - Age of Onset KW - Humans KW - Disease Progression KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Prevalence KW - Alcoholism -- epidemiology KW - Alcoholism -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70121010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Sequencing+the+lifetime+onset+of+alcohol-related+symptoms+in+older+adults%3A+is+there+evidence+of+disease+progression%3F&rft.au=Lemke%2C+Sonne%3BSchutte%2C+Kathleen+K%3BBrennan%2C+Penny+L%3BMoos%2C+Rudolf+H&rft.aulast=Lemke&rft.aufirst=Sonne&rft.date=2005-11-01&rft.volume=66&rft.issue=6&rft.spage=756&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-25 N1 - Date created - 2006-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Health effects in Army Gulf War veterans possibly exposed to chemical munitions destruction at Khamisiyah, Iraq: Part I. Morbidity associated with potential exposure. AN - 70114254; 16450821 AB - In March 1991, U.S. troops detonated the Khamisiyah, Iraq, ammunition depot, possibly releasing two chemical warfare agents, sarin and cyclosarin. The long-term health effects associated with possible exposure to these chemical warfare agents are unknown. This study was undertaken to investigate whether possible exposure was associated with morbidity among Army Gulf War veterans using morbidity data for 5,555 Army veterans who were deployed to the Gulf region. Responses to 86 self-assessed health measures, as reported in the 1995 Department of Veterans Affairs National Health Survey of Gulf War Era Veterans, were evaluated. We found little association between potential exposure and health, after adjustment for demographic variables, and conclude that potential exposure to sarin or cyclosarin at Khamisiyah does not seem to have adversely affected self-perceived health status, as evidenced by a wide range of health measures. JF - Military medicine AU - Mahan, Clare M AU - Page, William F AU - Bullman, Tim A AU - Kang, Han K AD - Veterans Health Administration, Department of Veterans Affairs, Washington, DC 20420, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 935 EP - 944 VL - 170 IS - 11 SN - 0026-4075, 0026-4075 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - United States KW - Humans KW - Cohort Studies KW - Adult KW - Surveys and Questionnaires KW - Male KW - Iraq KW - Female KW - Military Medicine KW - Veterans KW - Hazardous Substances -- adverse effects KW - Gulf War KW - Environmental Exposure KW - Morbidity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70114254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+medicine&rft.atitle=Health+effects+in+Army+Gulf+War+veterans+possibly+exposed+to+chemical+munitions+destruction+at+Khamisiyah%2C+Iraq%3A+Part+I.+Morbidity+associated+with+potential+exposure.&rft.au=Mahan%2C+Clare+M%3BPage%2C+William+F%3BBullman%2C+Tim+A%3BKang%2C+Han+K&rft.aulast=Mahan&rft.aufirst=Clare&rft.date=2005-11-01&rft.volume=170&rft.issue=11&rft.spage=935&rft.isbn=&rft.btitle=&rft.title=Military+medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-24 N1 - Date created - 2006-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Randomized placebo-controlled trial of a selective serotonin reuptake inhibitor in the treatment of nondepressed tinnitus subjects. AN - 68844473; 16314604 AB - To assess the efficacy of a selective serotonin reuptake inhibitor (paroxetine) for relief of tinnitus. One hundred twenty tinnitus sufferers participated in a randomized double-blind placebo-controlled trial. Paroxetine or placebo was increased to a maximally tolerated dose (up to 50 mg/day), and patients were treated for a total of 31 days at the maximal dose. Patients with chronic tinnitus were recruited from our university-based specialty clinic by referral from otolaryngologists and audiologists in the local community and by advertisement. Patients with psychotic or substance use disorders or suicidal ideation were excluded, as were those using psychoactive medications (this resulted in only 1 subject with major depression in the study) or any other medications that interact with paroxetine and those with inability to hear at one's tinnitus sensation level. Fifty-eight percent of patients were male, 92% were Caucasian, and the average age was 57. Tinnitus matching, the Tinnitus Handicap Questionnaire, the question: How severe (bothered, aggravating) is your tinnitus? Quality of Well-Being and other psychological questionnaires. Paroxetine was not statistically superior to placebo on the following tinnitus measures (tinnitus matching, 5- or 10-db drop, Tinnitus Handicap Questionnaire, quality of well-being measures, how severe, how bothered, positive change). There was a significant improvement in the single item question, How aggravating is your tinnitus? for those in the paroxetine group compared with the placebo group. These results suggest that the majority of individuals in this study did not benefit from paroxetine in a consistent fashion. Further work remains to be done to determine if subgroups of patients (e.g., those who tolerate higher doses, those who are depressed) may benefit. JF - Psychosomatic medicine AU - Robinson, Shannon K AU - Viirre, Erik S AU - Bailey, Kelly A AU - Gerke, Melissa A AU - Harris, Jeffery P AU - Stein, Murray B AD - Department of Psychiatry, University of California, San Diego School of Medicine, Veterans Administration San Diego Healthcare System, La Jolla, CA 92161, USA. skrobinson@ucsd.edu PY - 2005 SP - 981 EP - 988 VL - 67 IS - 6 KW - Placebos KW - 0 KW - Serotonin Uptake Inhibitors KW - Paroxetine KW - 41VRH5220H KW - Index Medicus KW - Severity of Illness Index KW - Drug Administration Schedule KW - Attitude to Health KW - Humans KW - Health Status KW - Treatment Outcome KW - Surveys and Questionnaires KW - Middle Aged KW - Maximum Tolerated Dose KW - Male KW - Female KW - Tinnitus -- psychology KW - Tinnitus -- diagnosis KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Tinnitus -- drug therapy KW - Paroxetine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68844473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatic+medicine&rft.atitle=Randomized+placebo-controlled+trial+of+a+selective+serotonin+reuptake+inhibitor+in+the+treatment+of+nondepressed+tinnitus+subjects.&rft.au=Robinson%2C+Shannon+K%3BViirre%2C+Erik+S%3BBailey%2C+Kelly+A%3BGerke%2C+Melissa+A%3BHarris%2C+Jeffery+P%3BStein%2C+Murray+B&rft.aulast=Robinson&rft.aufirst=Shannon&rft.date=2005-11-01&rft.volume=67&rft.issue=6&rft.spage=981&rft.isbn=&rft.btitle=&rft.title=Psychosomatic+medicine&rft.issn=1534-7796&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-11 N1 - Date created - 2005-11-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Psychosom Med. 2006 Jan-Feb;68(1):1 p preceding 1 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bleeding Risk Index in an anticoagulation clinic. Assessment by indication and implications for care. AN - 68837843; 16307625 AB - The Outpatient Bleeding Risk Index (BRI) prospectively classified patients who were at high, intermediate, or low risk for warfarin-related major bleeding. However, there are only 2 published validation studies of the index and neither included veterans. To determine the accuracy of the BRI in patients attending a Veterans Affairs (VA) anticoagulation clinic and to specifically evaluate the accuracy of the BRI in patients with atrial fibrillation. Retrospective cohort study. Using the BRI, all patients managed by the Anticoagulation Clinic between January 1, 2001 and December 31, 2002 were classified as high, intermediate, or low risk for major bleeding. Bleeds were identified via quality-assurance reports. Poisson regression was used to determine whether there was an association between the index and the development of bleeding. The rate of major bleeding was 10.6%, 2.5%, and 0.8% per patient-year of warfarin in the high-, intermediate-, and low-risk groups, respectively. Patients in the high-risk category had 14 times the rate of major bleeding of those in the low-risk group (incidence rate ratio (IRR) 14; 95% confidence interval (CI), 1.9 to 104.7). The rate of major bleeding was significantly different between the high- and intermediate-risk categories (P<.001). Among those with atrial fibrillation, patients in the high-risk category had 6 times the major bleeding rate of those in the intermediate- and low-risk groups combined (IRR=6; 95% CI, 2.4 to 15.3). The BRI discriminates between high- and intermediate-risk patients in a VA anticoagulation clinic, including those with atrial fibrillation. JF - Journal of general internal medicine AU - Aspinall, Sherrie L AU - DeSanzo, Beth E AU - Trilli, Lauren E AU - Good, Chester B AD - Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA. sherrie.aspinall@med.va.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1008 EP - 1013 VL - 20 IS - 11 KW - Anticoagulants KW - 0 KW - Warfarin KW - 5Q7ZVV76EI KW - Index Medicus KW - Sensitivity and Specificity KW - Risk Factors KW - Humans KW - Atrial Fibrillation -- drug therapy KW - Cohort Studies KW - Retrospective Studies KW - Aged KW - Poisson Distribution KW - Male KW - Female KW - Risk Assessment KW - Decision Support Techniques KW - Hemorrhage -- epidemiology KW - Anticoagulants -- adverse effects KW - Warfarin -- adverse effects KW - Hemorrhage -- prevention & control KW - Hemorrhage -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68837843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+general+internal+medicine&rft.atitle=Bleeding+Risk+Index+in+an+anticoagulation+clinic.+Assessment+by+indication+and+implications+for+care.&rft.au=Aspinall%2C+Sherrie+L%3BDeSanzo%2C+Beth+E%3BTrilli%2C+Lauren+E%3BGood%2C+Chester+B&rft.aulast=Aspinall&rft.aufirst=Sherrie&rft.date=2005-11-01&rft.volume=20&rft.issue=11&rft.spage=1008&rft.isbn=&rft.btitle=&rft.title=Journal+of+general+internal+medicine&rft.issn=1525-1497&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-04 N1 - Date created - 2005-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Med. 1989 Aug;87(2):144-52 [2787958] Am J Med. 1990 Nov;89(5):569-78 [2239976] Chest. 2001 Jan;119(1 Suppl):194S-206S [11157649] JAMA. 2002 Nov 20;288(19):2441-8 [12435257] Arch Intern Med. 2003 Apr 28;163(8):917-20 [12719200] Ann Intern Med. 2003 May 20;138(10):831-8 [12755555] Arch Intern Med. 2003 Jul 14;163(13):1580-6 [12860581] Ann Intern Med. 2003 Dec 16;139(12):1018-33 [14678922] Chest. 2004 Sep;126(3 Suppl):287S-310S [15383476] Am J Gastroenterol. 1995 Feb;90(2):206-10 [7847286] Am Heart J. 1996 Nov;132(5):1095-100 [8892802] J Gen Intern Med. 1996 Dec;11(12):713-20 [9016417] J Gen Intern Med. 1996 Dec;11(12):721-8 [9016418] Am J Gastroenterol. 1997 Mar;92(3):419-24 [9068461] BMJ. 1997 May 24;314(7093):1529-30 [9183202] Am J Med. 1998 Aug;105(2):91-9 [9727814] Arch Intern Med. 1999 Mar 8;159(5):457-60 [10074953] Comment In: Evid Based Med. 2006 Aug;11(4):120 [17213133] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethnic disparities in the use of nicotine replacement therapy for smoking cessation in an equal access health care system. AN - 68802881; 16295702 AB - To examine ethnic variations in the use of nicotine replacement therapy (NRT) in an equal access health care system. Cross-sectional survey. Eighteen Veterans Affairs medical and ambulatory care centers. A cohort of male current smokers (n = 1606). Use of NRT (nicotine patch or nicotine gum), ethnicity, sociodemographics, health status, smoking-related history, and facility prescribing policy. Overall, only 34% of African-American and 26% of Hispanic smokers have ever used NRT as a cessation aid compared with 50% of white smokers. In the past year, African-American smokers were most likely to have attempted quitting. During a serious past-year quit attempt, however African-American and Hispanic smokers reported lower rates of NRT use than white smokers (20% vs. 22% vs. 34%, respectively, p = .001). In multivariate analyses, ethnicity was independently associated with NRT use during a past-year quit attempt. Compared with white smokers, African-American (adjusted odds ratio, .53; 95% confidence interval, .34-.83) and Hispanic (adjusted odds ratio, .55; 95% confidence interval, .28-1.08) smokers were less likely to use NRT. Assessment of variations in use of NRT demonstrates that African-American and Hispanic smokers are less likely to use NRT during quit attempts. Future research is needed on the relative contributions of patient, physician, and system features to gaps in guideline implementation to provide treatment for ethnic minority smokers. JF - American journal of health promotion : AJHP AU - Fu, Steven S AU - Sherman, Scott E AU - Yano, Elizabeth M AU - van Ryn, Michelle AU - Lanto, Andy B AU - Joseph, Anne M AD - Section of General Internal Medicine, Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA. Steven.Fu@med.va.gov PY - 2005 SP - 108 EP - 116 VL - 20 IS - 2 SN - 0890-1171, 0890-1171 KW - Health technology assessment KW - Cross-Sectional Studies KW - Humans KW - Cohort Studies KW - Aged KW - Middle Aged KW - Ambulatory Care Facilities KW - Male KW - Ethnic Groups KW - Tobacco Use Disorder -- therapy KW - Smoking Cessation -- methods KW - Health Services Accessibility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68802881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health+promotion+%3A+AJHP&rft.atitle=Ethnic+disparities+in+the+use+of+nicotine+replacement+therapy+for+smoking+cessation+in+an+equal+access+health+care+system.&rft.au=Fu%2C+Steven+S%3BSherman%2C+Scott+E%3BYano%2C+Elizabeth+M%3Bvan+Ryn%2C+Michelle%3BLanto%2C+Andy+B%3BJoseph%2C+Anne+M&rft.aulast=Fu&rft.aufirst=Steven&rft.date=2005-11-01&rft.volume=20&rft.issue=2&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health+promotion+%3A+AJHP&rft.issn=08901171&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-09 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effects of diseases, drugs, and chemicals on the creativity and productivity of famous sculptors, classic painters, classic music composers, and authors. AN - 68738045; 16253027 AB - Many myths, theories, and speculations exist as to the exact etiology of the diseases, drugs, and chemicals that affected the creativity and productivity of famous sculptors, classic painters, classic music composers, and authors. To emphasize the importance of a modern clinical chemistry laboratory and hematology coagulation laboratory in interpreting the basis for the creativity and productivity of various artists. This investigation analyzed the lives of famous artists, including classical sculptor Benvenuto Cellini; classical sculptor and painter Michelangelo Buonarroti; classic painters Ivar Arosenius, Edvard Munch, and Vincent Van Gogh; classic music composer Louis Hector Berlioz; and English essayist Thomas De Quincey. The analysis includes their illnesses, their famous artistic works, and the modern clinical chemistry, toxicology, and hematology coagulation tests that would have been important in the diagnosis and treatment of their diseases. The associations between illness and art may be close and many because of both the actual physical limitations of the artists and their mental adaptation to disease. Although they were ill, many continued to be productive. If modern clinical chemistry, toxicology, and hematology coagulation laboratories had existed during the lifetimes of these various well-known individuals, clinical laboratories might have unraveled the mysteries of their afflictions. The illnesses these people endured probably could have been ascertained and perhaps treated. Diseases, drugs, and chemicals may have influenced their creativity and productivity. JF - Archives of pathology & laboratory medicine AU - Wolf, Paul L AD - Department of Pathology and Laboratory Medicine, University of California, VA Medical Center, San Diego, CA 92103, USA. paul.wolf@med.va.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1457 EP - 1464 VL - 129 IS - 11 KW - Xenobiotics KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Efficiency KW - History, 20th Century KW - Hematologic Tests -- history KW - Toxicology -- history KW - Chemistry, Clinical -- history KW - History, 18th Century KW - History, 15th Century KW - History, 19th Century KW - History, 16th Century KW - Disease -- etiology KW - Drug-Related Side Effects and Adverse Reactions KW - Famous Persons KW - Disease -- psychology KW - Xenobiotics -- adverse effects KW - Creativity KW - Humanities -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68738045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+pathology+%26+laboratory+medicine&rft.atitle=The+effects+of+diseases%2C+drugs%2C+and+chemicals+on+the+creativity+and+productivity+of+famous+sculptors%2C+classic+painters%2C+classic+music+composers%2C+and+authors.&rft.au=Wolf%2C+Paul+L&rft.aulast=Wolf&rft.aufirst=Paul&rft.date=2005-11-01&rft.volume=129&rft.issue=11&rft.spage=1457&rft.isbn=&rft.btitle=&rft.title=Archives+of+pathology+%26+laboratory+medicine&rft.issn=1543-2165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Family history of suicide, female sex, and childhood trauma: separate or interacting risk factors for attempts at suicide? AN - 68688035; 16223424 AB - Female sex, childhood trauma, and a family history of suicidal behavior are three well established risk factors for attempting suicide. However, interactions between these three factors in attempting suicide have been little studied. One thousand eight hundred and eighty-nine abstinent substance dependent patients were interviewed about their lifetime and family history of suicidal behavior and completed the Childhood Trauma Questionnaire (CTQ). Gender, family history of suicidal behavior, and CTQ scores--and their interaction--were examined in relation to suicidal behavior. Each of the three risk factors was associated with at least a doubling of the risk for an attempt at suicide. There were no significant interactions in relation to the risk of making an attempt. However, female sex and higher levels of childhood trauma each discriminated patients at risk for both a younger age of first attempting suicide and for making more attempts. Female sex, childhood trauma, and a family history of suicidal behavior are each independent, and non-interacting, risk factors for attempting suicide. Additionally, female sex and high childhood trauma are independent risk factors for both an early onset of first attempting suicide and for making more attempts. JF - Acta psychiatrica Scandinavica AU - Roy, A AU - Janal, M AD - Psychiatry Service 116A, Department of Veterans Affairs, New Jersey Healthcare System, East Orange, NJ 07018, USA. alec.roy@med.va.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 367 EP - 371 VL - 112 IS - 5 SN - 0001-690X, 0001-690X KW - Index Medicus KW - Pedigree KW - Cross-Sectional Studies KW - Sex Factors KW - Risk Factors KW - Humans KW - Adult KW - Child KW - Substance-Related Disorders -- psychology KW - Male KW - Female KW - Wounds and Injuries -- psychology KW - Child Abuse -- psychology KW - Suicide, Attempted -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68688035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+psychiatrica+Scandinavica&rft.atitle=Family+history+of+suicide%2C+female+sex%2C+and+childhood+trauma%3A+separate+or+interacting+risk+factors+for+attempts+at+suicide%3F&rft.au=Roy%2C+A%3BJanal%2C+M&rft.aulast=Roy&rft.aufirst=A&rft.date=2005-11-01&rft.volume=112&rft.issue=5&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Acta+psychiatrica+Scandinavica&rft.issn=0001690X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-10-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Safety of Outpatient Dalteparin Therapy in Veterans with Mechanical Heart Valves AN - 17137485; 6784270 AB - To determine the rate of bleeding and thromboembolic events within 1 month of outpatient dalteparin therapy in veterans with mechanical heart valves, to evaluate potential risk factors associated with these events, and to examine the prescribing patterns of dalteparin in this patient population. Single-center retrospective electronic chart review. Large, academically affiliated Veterans Affairs hospital. Thirty-eight men with mechanical heart valves who received outpatient prescriptions for dalteparin from October 1, 1998-June 30, 2003. Charts were reviewed for thromboembolic and bleeding events. Demographic, clinical, and drug utilization variables were assessed. The associations of adverse events with potential risk factors, indication for dalteparin therapy, and prescribing clinic were analyzed. Sixty-four dalteparin regimens were evaluated. No thromboembolic events were reported in any case within 1 month after receiving dalteparin for thromboembolic prophylaxis during warfarin interruption for periprocedural anticoagulation or for anticoagulation during an unintentional subtherapeutic international normalized ratio. Bleeding events occurred in 15 (23%) of the 64 regimens. Most bleeding events resolved spontaneously and without intervention. No potential risk factors for bleeding were identified. Dalteparin appeared to be a safe, effective means of short-term thromboembolic prophylaxis in this population of ambulatory male veterans with mechanical heart valves. Large, randomized, controlled, prospective trials are warranted. JF - Pharmacotherapy AU - O'Neill, J L AU - Flanagan, P S AU - Zaleon, C R AU - Copeland, LA AD - Veterans Affairs Ann Arbor Healthcare System, 2215 Fuller Road (119), Ann Arbor, MI 48105, USA, Jessica.Oneill@med.va.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 1560 EP - 1565 VL - 25 IS - 11 SN - 0277-0008, 0277-0008 KW - dalteparin KW - Health & Safety Science Abstracts KW - Cardiovascular system KW - Reviews KW - Drugs KW - Side effects KW - Thromboembolism KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17137485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Safety+of+Outpatient+Dalteparin+Therapy+in+Veterans+with+Mechanical+Heart+Valves&rft.au=O%27Neill%2C+J+L%3BFlanagan%2C+P+S%3BZaleon%2C+C+R%3BCopeland%2C+LA&rft.aulast=O%27Neill&rft.aufirst=J&rft.date=2005-11-01&rft.volume=25&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Archives+of+Environmental+Health&rft.issn=00039896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cardiovascular system; Reviews; Drugs; Thromboembolism; Side effects ER - TY - JOUR T1 - Speech recognition in multitalker babble using digits, words, and sentences. AN - 85396295; pmid-16515143 AB - The purpose of this mixed model design was to examine recognition performance differences when measuring speech recognition in multitalker babble on listeners with normal hearing (n = 36) and listeners with hearing loss (n = 72) utilizing stimulus of varying linguistic complexity (digits, words, and sentence materials). All listeners were administered two trials of two lists of each material in a descending speech-to-babble ratio. For each of the materials, recognition performances by the listeners with normal hearing were significantly better than the performances by the listeners with hearing loss. The mean separation between groups at the 50% point in signal-to-babble ratio on each of the three materials was approximately 8 dB. The 50% points for digits were obtained at a significantly lower signal-to-babble ratio than for sentences or words that were equivalent. There were no interlist differences between the two lists for the digits and words, but there was a significant disparity between QuickSIN lists for the listeners with hearing loss. A two-item questionnaire was used to obtain a subjective measurement of speech recognition, which showed moderate correlations with objective measures of speech recognition in noise using digits (r = .641), sentences (r = .572), and words (r = .673). JF - Journal of the American Academy of Audiology AU - McArdle, Rachel A AU - Wilson, Richard H AU - Burks, Christopher A AD - Bay Pines VA Healthcare System, Audiology (126), FL 33744, USA. Rachel.mcardle@med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 726 EP - 39; quiz 763-4 VL - 16 IS - 9 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Aged KW - Aged, 80 and over KW - Analysis of Variance KW - Audiometry, Speech KW - Case-Control Studies KW - *Hearing Loss, Sensorineural: physiopathology KW - Humans KW - Middle Aged KW - *Perceptual Masking: physiology KW - Psychometrics KW - *Speech Perception: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Speech+recognition+in+multitalker+babble+using+digits%2C+words%2C+and+sentences.&rft.au=McArdle%2C+Rachel+A%3BWilson%2C+Richard+H%3BBurks%2C+Christopher+A&rft.aulast=McArdle&rft.aufirst=Rachel&rft.date=2005-10-01&rft.volume=16&rft.issue=9&rft.spage=726&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Normative data for the Attitudes towards Loss of Hearing Questionnaire. AN - 85395730; pmid-16515136 AB - Investigations have shown that patient attitudes toward hearing loss and hearing aids impact self-reported handicap and disability, hearing aid benefit, and hearing aid use. The Attitudes towards Loss of Hearing Questionnaire (ALHQ) was developed by Saunders and Cienkowski (1996) to examine some of the psychosocial factors underlying the use and acquisition of hearing aids. Here we report data from a new version of questionnaire (ALHQ v2.1), which examines attitudes towards hearing loss and hearing aids on five scales: Denial of Hearing Loss, Negative Associations, Negative Coping Strategies, Manual Dexterity and Vision, and Hearing-Related Esteem. Reliability values, internal consistency values, and cut points for typical and atypical scores are provided, along with comparison of the scores of women, men, current hearing aid users, non-hearing aid users, and paying versus nonpaying individuals. The ALHQ takes about ten minutes to complete and identifies for the clinician some of the issues that might jeopardize successful hearing aid outcome. JF - Journal of the American Academy of Audiology AU - Saunders, Gabrielle H AU - Cienkowski, Kathleen M AU - Forsline, Anna AU - Fausti, Stephen AD - National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Oregon 97207, USA. Gabrielle.saunders@med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 637 EP - 652 VL - 16 IS - 9 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adaptation, Psychological KW - Aged KW - Aged, 80 and over KW - Analysis of Variance KW - Association KW - *Attitude to Health KW - Audiometry, Pure-Tone KW - Auditory Threshold KW - Denial (Psychology) KW - Female KW - *Hearing Aids: psychology KW - *Hearing Loss, Sensorineural: psychology KW - Humans KW - Linear Models KW - Male KW - Middle Aged KW - Motor Skills KW - Questionnaires: standards KW - Reference Values KW - Reproducibility of Results KW - Self Concept KW - Vision, Ocular UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85395730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Normative+data+for+the+Attitudes+towards+Loss+of+Hearing+Questionnaire.&rft.au=Saunders%2C+Gabrielle+H%3BCienkowski%2C+Kathleen+M%3BForsline%2C+Anna%3BFausti%2C+Stephen&rft.aulast=Saunders&rft.aufirst=Gabrielle&rft.date=2005-10-01&rft.volume=16&rft.issue=9&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Alterations of striatal neurons in benign hereditary chorea. AN - 85394809; pmid-15986422 AB - Benign hereditary chorea (BHC) recently has been associated with mutations in TITF-1 gene, although a pathological study of an individual with BHC and a TITF-1 mutation revealed no significant gross or microscopic abnormalities using standard methods. Immunohistochemical staining of striatal tissue from a BHC-affected postmortem brain was performed using antibodies against neurotransmitters of interneurons whose tangential migration is mediated by TITF-1. There was a loss of most TITF-1-mediated striatal interneurons in the BHC specimen compared to four matched control brains.Copyright (c) 2005 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Kleiner-Fisman, Galit AU - Calingasan, Noel Y AU - Putt, Mary AU - Chen, June AU - Beal, M Flint AU - Lang, Anthony E AD - Parkinson's Disease Research, Education and Clinical Center (PADRECC), Philadelphia VA Hospital, Philadelphia, Pennsylvania 19104, USA. galit.kleiner-fisman@med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 1353 EP - 1357 VL - 20 IS - 10 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Antibodies: immunology KW - Cell Movement KW - Chorea: genetics KW - Chorea: metabolism KW - *Chorea: pathology KW - Chromosomes, Human, Pair 14: genetics KW - Corpus Striatum: metabolism KW - *Corpus Striatum: pathology KW - Fatal Outcome KW - Humans KW - Immunohistochemistry KW - Interneurons: immunology KW - Interneurons: metabolism KW - Interneurons: pathology KW - Middle Aged KW - Neurons: metabolism KW - *Neurons: pathology KW - Neurotransmitter Agents: immunology KW - Nuclear Proteins: genetics KW - Nuclear Proteins: metabolism KW - Point Mutation: genetics KW - Transcription Factors: genetics KW - Transcription Factors: metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85394809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Alterations+of+striatal+neurons+in+benign+hereditary+chorea.&rft.au=Kleiner-Fisman%2C+Galit%3BCalingasan%2C+Noel+Y%3BPutt%2C+Mary%3BChen%2C+June%3BBeal%2C+M+Flint%3BLang%2C+Anthony+E&rft.aulast=Kleiner-Fisman&rft.aufirst=Galit&rft.date=2005-10-01&rft.volume=20&rft.issue=10&rft.spage=1353&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Combination docetaxel plus vitamin D(3) as an immune therapy in animals bearing squamous cell carcinomas. AN - 85394730; pmid-16213938 AB - Background tumor growth results in the mobilization of immune inhibitory CD34(+) progenitor cells. However, vitamin D(3) can differentiate the CD34(+) cells into immune stimulatory dendritic cells. This study determined if docetaxel treatment could increase the impact of the vitamin D(3) to generate dendritic cells.The murine squamous cell carcinoma model, SCC VII/SF, which is often used as a head and neck cancer model, was used to determine the immunological effects of two cycles of docetaxel plus vitamin D(3).Vitamin D(3) with or without docetaxel was similarly effective in reducing CD34(+) cell levels within the spleen, lymph nodes, and tumor. Dendritic cell levels were similarly enhanced in the lymph nodes by vitamin D(3) alone or combined with docetaxel. However, the combination treatment caused a prominent increase in intratumoral levels of active T cells, which was not observed by the individual treatments.Incorporating docetaxel treatment with vitamin D(3) differentiation-inducing treatment enhances intratumoral immune responsiveness. JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery AU - Young, M Rita I AU - Lathers, Deanne M R AD - Department of Research Services, Ralph H. Johnson V.A. Medical Center, Charleston, South Carolina 29401, USA. rita.young@med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 611 EP - 618 VL - 133 IS - 4 SN - 0194-5998, 0194-5998 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Antigens, CD: metabolism KW - *Antineoplastic Agents, Phytogenic: administration & dosage KW - *Carcinoma, Squamous Cell: drug therapy KW - Carcinoma, Squamous Cell: metabolism KW - Carcinoma, Squamous Cell: pathology KW - Cell Count KW - *Cholecalciferol: administration & dosage KW - Dendritic Cells KW - Disease Models, Animal KW - Drug Therapy, Combination KW - Interferon-gamma: metabolism KW - Lymph Nodes: metabolism KW - Lymph Nodes: pathology KW - Mice KW - Spleen: metabolism KW - Spleen: pathology KW - Stem Cells KW - T-Lymphocytes KW - *Taxoids: administration & dosage KW - *Vitamins: administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85394730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=Combination+docetaxel+plus+vitamin+D%283%29+as+an+immune+therapy+in+animals+bearing+squamous+cell+carcinomas.&rft.au=Young%2C+M+Rita+I%3BLathers%2C+Deanne+M+R&rft.aulast=Young&rft.aufirst=M+Rita&rft.date=2005-10-01&rft.volume=133&rft.issue=4&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - General review of tinnitus: prevalence, mechanisms, effects, and management. AN - 85389512; pmid-16411806 AB - Tinnitus is an increasing health concern across all strata of the general population. Although an abundant amount of literature has addressed the many facets of tinnitus, wide-ranging differences in professional beliefs and attitudes persist concerning its clinical management. These differences are detrimental to tinnitus patients because the management they receive is based primarily on individual opinion (which can be biased) rather than on medical consensus. It is thus vitally important for the tinnitus professional community to work together to achieve consensus. To that end, this article provides a broad-based review of what is presently known about tinnitus, including prevalence, associated factors, theories of pathophysiology, psychological effects, effects on disability and handicap, workers' compensation issues, clinical assessment, and various forms of treatment. This summary of fundamental information has relevance to both clinical and research arenas. JF - Journal of speech, language, and hearing research : JSLHR AU - Henry, James A AU - Dennis, Kyle C AU - Schechter, Martin A AD - Veterans Affairs Medical Center, Portland, OR 97207, USA. james.henry@med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 1204 EP - 1235 VL - 48 IS - 5 SN - 1092-4388, 1092-4388 KW - Index Medicus KW - National Library of Medicine KW - Adaptation, Psychological KW - *Auditory Pathways: physiopathology KW - Disability Evaluation KW - Hearing Disorders: economics KW - *Hearing Disorders: etiology KW - Humans KW - Prevalence KW - Quality of Life KW - Questionnaires KW - Risk Factors KW - Sickness Impact Profile KW - Tinnitus: epidemiology KW - Tinnitus: etiology KW - Tinnitus: psychology KW - Tinnitus: therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85389512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.atitle=General+review+of+tinnitus%3A+prevalence%2C+mechanisms%2C+effects%2C+and+management.&rft.au=Henry%2C+James+A%3BDennis%2C+Kyle+C%3BSchechter%2C+Martin+A&rft.aulast=Henry&rft.aufirst=James&rft.date=2005-10-01&rft.volume=48&rft.issue=5&rft.spage=1204&rft.isbn=&rft.btitle=&rft.title=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.issn=10924388&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Mitigating cutaneous side effects of lamotrigine. AN - 68821262; 16297026 JF - Perspectives in psychiatric care AU - Antai-Otong, Deborah AD - deborah.antai-otong@med.va.gov PY - 2005 SP - 193 EP - 196 VL - 41 IS - 4 SN - 0031-5990, 0031-5990 KW - Antimanic Agents KW - 0 KW - Triazines KW - lamotrigine KW - U3H27498KS KW - Nursing KW - Humans KW - Stevens-Johnson Syndrome -- chemically induced KW - Bipolar Disorder -- drug therapy KW - Antimanic Agents -- adverse effects KW - Antimanic Agents -- therapeutic use KW - Exanthema -- chemically induced KW - Triazines -- adverse effects KW - Triazines -- therapeutic use KW - Drug Prescriptions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68821262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+in+psychiatric+care&rft.atitle=Mitigating+cutaneous+side+effects+of+lamotrigine.&rft.au=Antai-Otong%2C+Deborah&rft.aulast=Antai-Otong&rft.aufirst=Deborah&rft.date=2005-10-01&rft.volume=41&rft.issue=4&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Perspectives+in+psychiatric+care&rft.issn=00315990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-15 N1 - Date created - 2005-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition. AN - 68756057; 16266282 AB - This review will focus primarily on the role of the low density lipoprotein receptor-related protein (LRP-1) in neuronal synapse formation and function in Alzheimer's Disease (AD). We review the role that its ligands may have in cognition or AD: apolipoprotein E (ApoE), alpha2-macroglobulin, Transforming Growth Factor-Beta (TGFbeta, Tissue Plasminogen Activator (tPA), insulin growth factor binding protein-3 (IGFBP-3), which all bind LRP-1 and apolipoprotein J (ApoJ), which is a ligand for LRP-2. After reviewing its role as a signaling receptor, we discuss the connection between LRP and the NMDA glutamate receptor via the post synaptic density 95 (PSD-95) neuronal scaffold protein and the implications it may have for memory and cognition. Finally, we discuss the evidence supporting a role for LRP in AD. Although the evidence for LRP as a genetic risk factor is weak, many of its ligands impose genetic risk, and have been implicated in AD pathogenic cascades. We discuss the role of LRP in amyloid precursor protein (APP) processing and production of beta-amyloid (Abeta. We identify LRP ligands that accelerate aggregation of toxic Abeta species. LRP mediates crucial pathways in AD pathogenesis such as Abeta clearance, Abeta uptake, intraneuronal Abeta accumulation and Abeta-associated neuron death. Interestingly, the TGFbeta -V receptor is LRP-1. Data show that one critical ligand TGFbeta2, associated with neurodegeneration in amyloid diseases, induces LRP expression in PC12 cells. Data from rodent infusion models demonstrate the impact of TGFbeta2 in modifying Abeta- induced Long Term Potentiation (LTP) responses, presynaptic proteins, lipid peroxidation, gliosis and staining for neuronal nuclei. The evidence supports a complex and significant role of LRP in cognition and AD. JF - Current drug targets. CNS and neurological disorders AU - Harris-White, M E AU - Frautschy, S A AD - University of California, Los Angeles, Department of Medicine, and the Veterans Administration Greater Los Angeles Healthcare System, Sepulveda 91343, USA. marni@ucla.edu Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 469 EP - 480 VL - 4 IS - 5 SN - 1568-007X, 1568-007X KW - Amyloid beta-Peptides KW - 0 KW - LDL-Receptor Related Proteins KW - Ligands KW - Receptors, N-Methyl-D-Aspartate KW - Index Medicus KW - Signal Transduction -- physiology KW - Animals KW - Humans KW - Mice KW - Receptors, N-Methyl-D-Aspartate -- metabolism KW - Mice, Knockout KW - Cognition -- physiology KW - Neurons -- metabolism KW - Amyloid beta-Peptides -- metabolism KW - Alzheimer Disease -- metabolism KW - LDL-Receptor Related Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68756057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+targets.+CNS+and+neurological+disorders&rft.atitle=Low+density+lipoprotein+receptor-related+proteins+%28LRPs%29%2C+Alzheimer%27s+and+cognition.&rft.au=Harris-White%2C+M+E%3BFrautschy%2C+S+A&rft.aulast=Harris-White&rft.aufirst=M&rft.date=2005-10-01&rft.volume=4&rft.issue=5&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Current+drug+targets.+CNS+and+neurological+disorders&rft.issn=1568007X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-23 N1 - Date created - 2005-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relative prevalence of comorbidities and treatment contraindications in HIV-mono-infected and HIV/HCV-co-infected veterans. AN - 68736602; 16251836 AB - To determine the prevalence of hepatitis C virus (HCV) co-infection among HIV-infected veterans, assess the prevalence of comorbid conditions that may complicate or limit treatment options, and ascertain whether comorbid conditions were more common in co-infected veterans. We used the Veterans Administration electronic medical records system to identify all veterans receiving care for HIV during fiscal years 1997-2002. Demographic data and diagnostic codes for HIV, HCV, and comorbid conditions were extracted. The validity of using diagnostic codes was assessed by calculating the agreement between chart extraction and electronic data on a separate sample of veterans. Factor analysis was used to identify the structure underlying the intercorrelation between comorbid conditions. Logistic regression was used to compare the prevalence of comorbid conditions and factors between HIV/HCV-co-infected and HIV-mono-infected veterans, adjusting for age and race. We identified 25,116 HIV-infected veterans in care, of whom 4489 (18%) were HCV co-infected. A validity assessment revealed moderate agreement between chart extraction and electronic data for each of the comorbid conditions assessed. HIV/HCV-co-infected veterans were significantly more likely to have each of the comorbid conditions, and to have significantly more comorbid conditions. Factor analysis revealed three dimensions of comorbidity: mental disorders, medical disorders, and alcohol-related complications. Veterans with co-infection were significantly more likely to have mental disorders and alcohol-related complications. HIV/HCV-co-infected veterans had a higher prevalence of comorbid conditions that may complicate and limit treatment options for HIV and for HCV co-infection. Strategies to improve treatment options for co-infected patients with comorbidities must be developed. JF - AIDS (London, England) AU - Goulet, Joseph L AU - Fultz, Shawn L AU - McGinnis, Kathleen A AU - Justice, Amy C AD - Yale University School of Medicine, New Haven, CT, USA. joseph.goulet@med.va.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - S99 EP - 105 VL - 19 Suppl 3 SN - 0269-9370, 0269-9370 KW - Index Medicus KW - AIDS/HIV KW - Epidemiologic Methods KW - Aged, 80 and over KW - Mental Disorders -- epidemiology KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Comorbidity KW - Substance-Related Disorders -- epidemiology KW - Veterans -- statistics & numerical data KW - Hepatitis C -- epidemiology KW - HIV Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68736602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Relative+prevalence+of+comorbidities+and+treatment+contraindications+in+HIV-mono-infected+and+HIV%2FHCV-co-infected+veterans.&rft.au=Goulet%2C+Joseph+L%3BFultz%2C+Shawn+L%3BMcGinnis%2C+Kathleen+A%3BJustice%2C+Amy+C&rft.aulast=Goulet&rft.aufirst=Joseph&rft.date=2005-10-01&rft.volume=19+Suppl+3&rft.issue=&rft.spage=S99&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-29 N1 - Date created - 2005-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alfuzosin for treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia: a systematic review of efficacy and adverse effects. AN - 68704102; 16230138 AB - To evaluate the efficacy and adverse effects of alfuzosin for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH). The included studies were randomized controlled trials involving men with symptomatic BPH treated with alfuzosin versus placebo or active control for at least 4 weeks. The search strategy identified 11 trials involving 3901 men with a mean age of 64 years. Eight trials were placebo-controlled studies, two were alfuzosin versus alternative alpha-blockers, and one was alfuzosin versus finasteride and combination alfuzosin/finasteride therapy. The study durations were short term, 4 to 26 weeks. The mean baseline symptom scores and peak urinary flow rates were indicative of moderate BPH. Alfuzosin (7.5 or 10 mg) improved lower urinary tract symptoms assessed by the International Prostate Symptom Score compared with placebo. The mean absolute change from baseline was -5.4 points for alfuzosin compared with -3.6 points for placebo, a weighted mean difference of 1.8 points (three studies). Alfuzosin increased the peak urinary flow more than did placebo, although the improvement varied across the eight studies. Symptom and flow improvements were generally comparable to that with combination therapy and with other alpha1-blockers. Alfuzosin had good short-term tolerability, and the numbers of study withdrawals were comparable to those with placebo and controls. Efficacy and short-term safety were similar across the various (immediate-release, sustained, and once-daily) formulations. The results from short-term studies have indicated that alfuzosin improves lower urinary tract symptoms and urinary flow more than does placebo and is generally well tolerated in men with symptomatic BPH. Long-term efficacy and safety studies in combination with a 5-alpha-reductase inhibitor should be initiated. JF - Urology AU - MacDonald, Roderick AU - Wilt, Timothy J AD - Minneapolis Veterans Affairs Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA. Roderick.MacDonald@med.va.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 780 EP - 788 VL - 66 IS - 4 KW - Adrenergic alpha-Antagonists KW - 0 KW - Quinazolines KW - alfuzosin KW - 90347YTW5F KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Humans KW - Male KW - Prostatic Hyperplasia -- drug therapy KW - Adrenergic alpha-Antagonists -- therapeutic use KW - Urination Disorders -- drug therapy KW - Urination Disorders -- etiology KW - Quinazolines -- therapeutic use KW - Quinazolines -- adverse effects KW - Adrenergic alpha-Antagonists -- adverse effects KW - Prostatic Hyperplasia -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68704102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urology&rft.atitle=Alfuzosin+for+treatment+of+lower+urinary+tract+symptoms+compatible+with+benign+prostatic+hyperplasia%3A+a+systematic+review+of+efficacy+and+adverse+effects.&rft.au=MacDonald%2C+Roderick%3BWilt%2C+Timothy+J&rft.aulast=MacDonald&rft.aufirst=Roderick&rft.date=2005-10-01&rft.volume=66&rft.issue=4&rft.spage=780&rft.isbn=&rft.btitle=&rft.title=Urology&rft.issn=1527-9995&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-28 N1 - Date created - 2005-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Training psychiatrists to diagnose and treat substance abuse disorders. AN - 68684657; 16216153 AB - Addiction training in psychiatric residency programs needs expansion. Epidemiology research has shown that patients with substance use disorders and co-occurring mental health disorders are the norm in nearly all clinical settings. Unfortunately, traditional training approaches built around brief rotations on detoxification or intensive substance abuse rehabilitation units do not adequately train psychiatrists in long-term management skills, and may reinforce misperceptions that these patients do not respond to treatment. An enhanced addiction curriculum coupled with an extended outpatient clinic rotation is an ideal model for teaching the skills needed to successfully care for these patients. Training must include an adequate knowledge base, an opportunity to cultivate positive attitudes toward these patients, and recognition that psychiatrists must take responsibility for treating the addiction problem and any co-occurring psychiatric disorders. The program developed at Boston University Medical Center successfully integrates expanded addiction psychiatry training into the general psychiatry residency. JF - Current psychiatry reports AU - Renner, John A AU - Quinones, Janice AU - Wilson, Amanda AD - VA Outpatient Clinic, 251 Causeway Street, Boston, MA 02114, USA. john.renner@med.va.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 352 EP - 359 VL - 7 IS - 5 SN - 1523-3812, 1523-3812 KW - Index Medicus KW - Outpatients KW - Diagnosis, Differential KW - Humans KW - Curriculum KW - Health Knowledge, Attitudes, Practice KW - Professional Competence KW - Substance-Related Disorders -- diagnosis KW - Internship and Residency KW - Psychiatry -- education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68684657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+psychiatry+reports&rft.atitle=Training+psychiatrists+to+diagnose+and+treat+substance+abuse+disorders.&rft.au=Renner%2C+John+A%3BQuinones%2C+Janice%3BWilson%2C+Amanda&rft.aulast=Renner&rft.aufirst=John&rft.date=2005-10-01&rft.volume=7&rft.issue=5&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Current+psychiatry+reports&rft.issn=15233812&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pulse versus continuous terbinafine for onychomycosis: a randomized, double-blind, controlled trial. AN - 68644505; 16198776 AB - Effective treatments for onychomycosis are expensive. Previous studies suggest that less costly, pulsed doses of antifungal medications may be as effective as standard, continuous doses. Terbinafine is the current treatment of choice for toenail onychomycosis. Our purpose was to determine whether pulse-dose terbinafine is as effective as standard continuous-dose terbinafine for treatment of toenail onychomycosis. We conducted a double-blind, randomized, noninferiority, clinical intervention trial in the Minneapolis Veterans Affairs Medical Center. The main inclusion criteria for participants were a positive dermatophyte culture and at least 25% distal subungual clinical involvement. Six hundred eighteen volunteers were screened; 306 were randomized. Terbinafine, 250 mg daily for 3 months (continuous) or terbinafine, 500 mg daily for 1 week per month for 3 months (pulse) was administered. The primary outcome measure was mycological cure of the target toenail at 18 months. Secondary outcome measures included clinical cure and complete (clinical plus mycological) cure of the target toenail and complete cure of all 10 toenails. Results of an intent-to-treat analysis did not meet the prespecified criterion for noninferiority but did demonstrate the superiority of continuous-dose terbinafine for: mycological cure of the target toenail (70.9% [105/148] vs 58.7% [84/143]; P =.03, relative risk [RR] of 1.21 [95% confidence interval (CI), 1.02-1.43]); clinical cure of the target toenail (44.6% [66/148] vs 29.3% [42/143]; P =.007, RR =1.52 [95% CI, 1.11-2.07); complete cure of the target toenail (40.5% [60/148] vs 28.0% [40/143]; P =.02, RR=1.45 [95% CI, 1.04-2.01); and complete cure of all 10 toenails (25.2% [36/143] vs 14.7% [21/143]; P =.03, RR =1.71 [95% CI, 1.05-2.79). Tolerability of the regimens did not differ significantly between the groups (chi2 =1.63; P =.65). The study population primarily consisted of older men with severe onychomycosis. This study demonstrated the superiority of continuous- over pulse-dose terbinafine. We also found this expensive therapy to be much less effective than previously believed, particularly for achieving complete cure of all 10 toenails. JF - Journal of the American Academy of Dermatology AU - Warshaw, Erin M AU - Fett, Debra D AU - Bloomfield, Hanna E AU - Grill, Joseph P AU - Nelson, David B AU - Quintero, Vicente AU - Carver, Susan M AU - Zielke, Gary R AU - Lederle, Frank A AD - Center for Chronic Disease Outcomes Research, Minneapolis, Minnesota, USA. erin.warshaw@med.va.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 578 EP - 584 VL - 53 IS - 4 KW - Antifungal Agents KW - 0 KW - Naphthalenes KW - Tablets KW - terbinafine KW - G7RIW8S0XP KW - Index Medicus KW - Pulse Therapy, Drug KW - Double-Blind Method KW - Humans KW - Treatment Outcome KW - Aged KW - Foot Dermatoses -- drug therapy KW - Male KW - Female KW - Antifungal Agents -- adverse effects KW - Naphthalenes -- administration & dosage KW - Naphthalenes -- adverse effects KW - Antifungal Agents -- administration & dosage KW - Onychomycosis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68644505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Pulse+versus+continuous+terbinafine+for+onychomycosis%3A+a+randomized%2C+double-blind%2C+controlled+trial.&rft.au=Warshaw%2C+Erin+M%3BFett%2C+Debra+D%3BBloomfield%2C+Hanna+E%3BGrill%2C+Joseph+P%3BNelson%2C+David+B%3BQuintero%2C+Vicente%3BCarver%2C+Susan+M%3BZielke%2C+Gary+R%3BLederle%2C+Frank+A&rft.aulast=Warshaw&rft.aufirst=Erin&rft.date=2005-10-01&rft.volume=53&rft.issue=4&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=1097-6787&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-10 N1 - Date created - 2005-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prescriptions for chronic high-dose cyclooxygenase-2 inhibitors are often inappropriate and potentially dangerous. AN - 68644370; 16191131 AB - To describe the use of coxibs outside of licensed indications and recommended dosing ranges including rofecoxib 50 mg, valdecoxib 20 to 40 mg, and celecoxib 400 mg. Cross-sectional study of coxib utilization in 2002 and 2003 and retrospective cohort analysis of new users. Patients with known age and sex enrolled in Tennessee's Medicaid program. The prevalence of coxib use by dose and duration, and the proportion of persons initially prescribed a high-dose coxib and indications for such use. The estimated daily prevalence of nonaspirin prescription nonsteroidal anti-inflammatory drugs (NSAIDs) was 8.7% in 2002 to 2003 (45.7% coxibs). NSAID use peaked at age 65 to 74 with a prevalence of 19.8% (56.3% coxibs). Doses above the recommended daily dose for osteoarthritis accounted for 33.2% (95% confidence intervals [CIs] 32.4%, 33.9%) of celecoxib use, 14.9% (95% CI 14.4%, 15.5%) of rofecoxib use, and 52.2% (95% CI 50.6%, 53.8%) of valdecoxib use. Most of these prescriptions were for a month's supply. For new coxib users, 13.5% were given a month's supply for the highest dose category, and 28% refilled their prescriptions within 7 days of the end of the original prescription. Of these new chronic high-dose users, 17.2% had ischemic heart disease and 7.1% had heart failure. A substantial portion of coxib prescriptions were for a month's supply at doses above those recommended for most chronic indications. New users were also prescribed high doses despite evidence for cardiovascular comorbidity. These prescribing patterns at doses outside licensed indications are both inappropriate and potentially dangerous. JF - Journal of general internal medicine AU - Roumie, Christianne L AU - Arbogast, Patrick G AU - Mitchel, Edward F AU - Griffin, Marie R AD - Veterans Administration, Tennessee Valley Healthcare System, Tennessee Valley Geriatric Research Education Clinical Center (GRECC), Nashville, Tenn 37212, USA. christianne.roumie@vanderbilt.edu Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 879 EP - 883 VL - 20 IS - 10 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase Inhibitors KW - Index Medicus KW - United States KW - Reproducibility of Results KW - Humans KW - Osteoarthritis -- drug therapy KW - Tennessee KW - Medicaid KW - Male KW - Female KW - Cyclooxygenase Inhibitors -- adverse effects KW - Drug Prescriptions -- standards KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Chronic Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68644370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+general+internal+medicine&rft.atitle=Prescriptions+for+chronic+high-dose+cyclooxygenase-2+inhibitors+are+often+inappropriate+and+potentially+dangerous.&rft.au=Roumie%2C+Christianne+L%3BArbogast%2C+Patrick+G%3BMitchel%2C+Edward+F%3BGriffin%2C+Marie+R&rft.aulast=Roumie&rft.aufirst=Christianne&rft.date=2005-10-01&rft.volume=20&rft.issue=10&rft.spage=879&rft.isbn=&rft.btitle=&rft.title=Journal+of+general+internal+medicine&rft.issn=1525-1497&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-01 N1 - Date created - 2005-09-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2005 Mar 17;352(11):1071-80 [15713944] N Engl J Med. 2005 Mar 17;352(11):1092-102 [15713943] Clin Ther. 1999 Oct;21(10):1688-702 [10566565] JAMA. 1999 Nov 24;282(20):1921-8 [10580457] N Engl J Med. 2000 Nov 23;343(21):1520-8, 2 p following 1528 [11087881] JAMA. 2001 Aug 22-29;286(8):954-9 [11509060] JAMA. 2002 Jul 17;288(3):321-33 [12117397] Lancet. 2002 Oct 5;360(9339):1071-3 [12383990] Am J Manag Care. 2002 Oct;8(15 Suppl):S392-400 [12416789] Lancet. 2002 Dec 14;360(9349):1903-13 [12493255] Pharmacoepidemiol Drug Saf. 2003 Jan-Feb;12(1):67-70 [12616850] J Thorac Cardiovasc Surg. 2003 Jun;125(6):1481-92 [12830070] Circulation. 2004 May 4;109(17):2068-73 [15096449] Pharmacoepidemiol Drug Saf. 2004 Jun;13(6):339-43 [15170762] N Engl J Med. 2004 Oct 21;351(17):1709-11 [15470192] N Engl J Med. 2004 Oct 21;351(17):1707-9 [15470193] Med Care. 1976 Feb;14(2):166-72 [768652] Ann Intern Med. 1988 Sep 1;109(5):359-63 [3261560] JAMA. 1998 Aug 19;280(7):605-13 [9718051] N Engl J Med. 1999 Sep 2;341(10):709-17 [10471456] N Engl J Med. 2005 Mar 17;352(11):1081-91 [15713945] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Challenges in the adoption of new pharmacotherapeutics for addiction to alcohol and other drugs. AN - 68619616; 16055196 AB - The adoption of pharmacotherapies for the treatment of alcohol and drug use disorders has progressed slowly despite the approval of new and effective medications. This paper begins with overviews of the prevalence of alcohol and drug abuse and dependence, the costs of addiction to the nation, and the value of treatment services. The role of pharmacotherapy in the treatment of addictive diseases is examined, and factors that affect the adoption and use of medications for alcohol and drug treatment are identified and discussed. Investigations that tested the effectiveness of buprenorphine for treatment of opioid dependence in new settings illustrate physician and counselor training and mentorship strategies that may promote the adoption of medications in the treatment of alcohol and drug use disorders. The paper concludes with a discussion of barriers and ways to surmount the barriers and to foster greater use of medications in alcohol and drug treatment. JF - Pharmacology & therapeutics AU - Saxon, Andrew J AU - McCarty, Dennis AD - Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98108, USA. andrew.saxon@med.va.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 119 EP - 128 VL - 108 IS - 1 SN - 0163-7258, 0163-7258 KW - Index Medicus KW - Alcoholism -- epidemiology KW - Alcoholism -- economics KW - Alcoholism -- drug therapy KW - Substance-Related Disorders -- drug therapy KW - Drug Therapy -- methods KW - Substance-Related Disorders -- economics KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68619616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+%26+therapeutics&rft.atitle=Challenges+in+the+adoption+of+new+pharmacotherapeutics+for+addiction+to+alcohol+and+other+drugs.&rft.au=Saxon%2C+Andrew+J%3BMcCarty%2C+Dennis&rft.aulast=Saxon&rft.aufirst=Andrew&rft.date=2005-10-01&rft.volume=108&rft.issue=1&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Pharmacology+%26+therapeutics&rft.issn=01637258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-05 N1 - Date created - 2005-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]. AN - 68591176; 16164626 AB - Excretion by the kidney of a variety of organic anionic drugs and metabolites is mediated by a family of multispecific organic anion transporters (OAT genes) that are part of the SLC22 family of solute carriers. Different OATs localize to the apical (OAT2, OAT4, and RST/URAT) or basolateral (OAT1/NKT and OAT3) membranes of the renal proximal tubule; the net transport of organic anions from blood to urine is believed to require both apical and basolateral OATs. These genes are also thought to mediate transport of organic anionic drugs and metabolites (e.g., urate) across choroid plexus, retina, placenta, and possibly olfactory mucosa. The extent of functional redundancy among OATs remains uncertain, but closely related OAT genes are tightly linked in the genome. Hence, a better understanding of human variation in organic anionic drug excretion may be obtained by studying OAT genes in combination rather than individually. We have analyzed single nucleotide polymorphisms (SNPs) in OAT1 (NKT), OAT2, OAT3, OAT4, and URAT1 (human homologue of RST) in an ethnically diverse sample of 96 individuals (192 haploid genomes). Ka/Ks analysis was also performed as well as haplotype reconstruction using the software program Arelquin. The data indicate that (1) nonsynonymous SNPs in OAT1 and OAT3 may not be frequent so it will be important to consider promoter region SNPs that regulate gene expression; (2) certain ethnic groups may have a high prevalence of nonsynonymous SNPs in particular OATs (e.g., OAT4 in Sub-Saharan Africans); (3) there are individuals who have nonsynonymous SNPs in apical and basolateral OATs; (4) nonsynonymous OAT4 SNPs may be more frequent, raising the possibility of altered maternofetal transport of drugs and metabolites; and (5) combinations of synonymous SNPs in OAT1 and OAT3 also occur in certain individuals. In addition, Ka/Ks analysis of human, chimp and rodent genes suggests that OAT4 is under accelerated selection pressure, perhaps reflecting specific human environmental exposures during evolution. In contrast, Ka/Ks analysis for URAT1 suggests decelerated selection pressure. Haplotype reconstruction also supports this view. Together, these data suggest that, in order to understand the effect of SNPs in genes of the SLC22 family on drug handling as well as excretion of metabolites like uric acid, it is important to consider the entire set of organic anion transporters. It will be particularly interesting to determine if individuals with nonsynonymous apical and basolateral SNPs have altered handling (and toxicity) of organic anionic drugs and metabolites. Certain OAT family members appear to be under greater evolutionary selection pressure. JF - Kidney international AU - Xu, Gang AU - Bhatnagar, Vibha AU - Wen, Gen AU - Hamilton, Bruce A AU - Eraly, Satish A AU - Nigam, Sanjay K AD - Department of Pediatrics, Family and Preventative Medicine and San Diego Veterans Administration Medical Center, University of California San Diego, La Jolla, California 92161, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1491 EP - 1499 VL - 68 IS - 4 SN - 0085-2538, 0085-2538 KW - Carrier Proteins KW - 0 KW - Organic Anion Transport Protein 1 KW - Organic Anion Transporters KW - Organic Anion Transporters, Sodium-Independent KW - Organic Cation Transport Proteins KW - SLC22A11 protein, human KW - SLC22A12 protein, human KW - SLC22A7 protein, human KW - organic anion transport protein 3 KW - Index Medicus KW - Organic Anion Transporters, Sodium-Independent -- genetics KW - Cell Polarity -- physiology KW - Organic Anion Transport Protein 1 -- genetics KW - Haplotypes KW - Humans KW - Carrier Proteins -- genetics KW - Polymorphism, Single Nucleotide KW - Organic Anion Transporters -- genetics KW - Kidney -- physiology KW - Kidney -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68591176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Analyses+of+coding+region+polymorphisms+in+apical+and+basolateral+human+organic+anion+transporter+%28OAT%29+genes+%5BOAT1+%28NKT%29%2C+OAT2%2C+OAT3%2C+OAT4%2C+URAT+%28RST%29%5D.&rft.au=Xu%2C+Gang%3BBhatnagar%2C+Vibha%3BWen%2C+Gen%3BHamilton%2C+Bruce+A%3BEraly%2C+Satish+A%3BNigam%2C+Sanjay+K&rft.aulast=Xu&rft.aufirst=Gang&rft.date=2005-10-01&rft.volume=68&rft.issue=4&rft.spage=1491&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-30 N1 - Date created - 2005-09-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of Trauma Exposure on Anger, Aggression, and Violence in a Nonclinical Sample of Men AN - 61299317; 200602236 AB - This study assessed the impact of traumatic exposure & posttraumatic stress disorder (PTSD) symptoms on anger, aggression, & violence among civilian male college Students. Results suggest that civilian men who have been exposed to a potentially traumatic event (PTE) & report symptoms of PTSD indicate more trait anger, more internal anger & hostility, & more aggression & violence than men who do not report symptoms of PTSD. Results are contrasted to those found in clinical samples of male veterans with PTSD & discussed in terms of understanding & treating anger & aggression in nonclinical, trauma-exposed populations. Tables, References. Adapted from the source document. JF - Violence and Victims AU - Jakupcak, Matthew AU - Tull, Matthew T AD - MIRECC, Veterans Affairs Puget Sound Health Care System, Seattle, WA matthew.jakupcak@med.va.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 589 EP - 598 PB - Springer Publishing Co., New York NY VL - 20 IS - 5 SN - 0886-6708, 0886-6708 KW - PTSD KW - anger KW - hostility KW - aggression KW - Veterans KW - Males KW - College Students KW - Posttraumatic Stress Disorder KW - Aggression KW - Violence KW - Anger KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61299317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Violence+and+Victims&rft.atitle=Effects+of+Trauma+Exposure+on+Anger%2C+Aggression%2C+and+Violence+in+a+Nonclinical+Sample+of+Men&rft.au=Jakupcak%2C+Matthew%3BTull%2C+Matthew+T&rft.aulast=Jakupcak&rft.aufirst=Matthew&rft.date=2005-10-01&rft.volume=20&rft.issue=5&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Violence+and+Victims&rft.issn=08866708&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-10-30 N1 - Number of references - 13 N1 - Last updated - 2016-09-28 N1 - CODEN - VIOVEI N1 - SubjectsTermNotLitGenreText - Anger; Males; Violence; Aggression; Posttraumatic Stress Disorder; Veterans; College Students ER - TY - JOUR T1 - An Evaluation of Cognitive Processing Therapy for the Treatment of Posttraumatic Stress Disorder Related to Childhood Sexual Abuse AN - 57171621; 200602518 AB - This study compared the effectiveness of cognitive processing therapy for sexual abuse survivors (CPT-SA) with that of the minimal attention (MA) given to a wait-listed control group. Seventy-one women were randomly assigned to 1 of the 2 groups. Participants were assessed at pretreatment & 3 times during posttreatment: immediately after treatment & at 3-month & 1-year follow-up, using the Clinician-Administered Posttraumatic Stress Disorder (PTSD) Scale (D. Blake et al., 1995), the Beck Depression Inventory (A. T. Beck, R. A. Steer, & G. K. Brown, 1996), the Structured Clinical Interview for the DSM-IV (R. L. Spitzer, J. B. W. Williams, & M. Gibbon, 1995; M. B. First et al., 1995), the Dissociative Experiences Scale-II (E. M. Bernstein & F. W. Putnam, 1986), & the Modified PTSD Symptom Scale (S. A. Falsetti, H. S. Resnick, P. A. Resick, & D. G. Kilpatrick, 1993). Analyses suggested that CPT-SA is more effective for reducing trauma-related symptoms than is MA, & the results were maintained for at least 1 year. 2 Tables, 42 References. [Copyright 2005 American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Chard, Kathleen M AD - Cincinati VA Medical Center, PTSD Division, Cincinnati, OH Kathleen.chard@med.va.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 965 EP - 971 VL - 73 IS - 5 SN - 0022-006X, 0022-006X KW - PTSD, child sexual abuse, cognitive therapy, trauma, treatment KW - Posttraumatic stress disorder KW - Women KW - Cognitive therapy KW - Childhood sexual abuse KW - Treatment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57171621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=An+Evaluation+of+Cognitive+Processing+Therapy+for+the+Treatment+of+Posttraumatic+Stress+Disorder+Related+to+Childhood+Sexual+Abuse&rft.au=Chard%2C+Kathleen+M&rft.aulast=Chard&rft.aufirst=Kathleen&rft.date=2005-10-01&rft.volume=73&rft.issue=5&rft.spage=965&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Childhood sexual abuse; Cognitive therapy; Treatment; Women ER - TY - JOUR T1 - HIV, hepatitis C and HIV/hepatitis C virus co-infection in vulnerable populations AN - 21044598; 6561547 AB - Objective: To describe basic patient demographic and clinical characteristics of HIV-infected and HIV/hepatitis C virus (HCV)-co-infected patients receiving care in the Department of Veterans Affairs (VA) with a focus on some patient factors that place such patients at an increased risk of poor health outcomes. Design: An observational retrospective cohort study. Methods: The study cohort consisted of veterans in the VA Immunology Case Registry who received care in the VA in 2002. Results: Of 18 349 HIV-infected patients, 6782 (37.0%) were HCV seropositive. Compared with HIV-alone-infected patients, HIV/HCV-co-infected patients were older, more likely to be men, more likely to be black or Hispanic, and more likely to report intravenous drug use as a risk factor for HIV acquisition. HIV/HCV-co-infected patients were more likely to have diagnoses of mental health illness, depression, alcohol abuse, substance abuse and hard drug abuse compared with HIV-alone-infected patients. Co-infected patients were less likely to have a history of an AIDS opportunistic infection ever and were less likely to have received HIV antiretroviral drugs in 2002. Conclusion: The VA's HIV and HIV/HCV-co-infected patient populations have very high rates of additional comorbid conditions that complicate both the pharmacological therapy and clinical course of both HIV and HCV infections. Given the overlap in viral illness and comorbidities, optimal models of integrated care need to be developed for populations with HIV, HCV, and HIV/HCV co-infection and who need substance abuse treatment or mental healthcare. JF - AIDS AU - Backus, LI AU - Boothroyd, D AU - Deyton, L R AD - PHSHCG 13B, US Department of Veterans Affairs, 810 Vermont Avenue NW, Washington, DC 20420, USA, dr.bopper.deyton@hq.med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - S13 EP - S19 VL - 19 SN - 0269-9370, 0269-9370 KW - HIV KW - Immunology Abstracts; Risk Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Risk assessment KW - drug abuse KW - Alcohol KW - Historical account KW - Acquired immune deficiency syndrome KW - Intravenous administration KW - Depression KW - Drug abuse KW - Morbidity KW - Models KW - Opportunist infection KW - Hepatitis KW - substance abuse KW - Demography KW - infectious diseases KW - Mental disorders KW - Hepatitis C virus KW - Health care KW - Antiviral agents KW - Human immunodeficiency virus KW - Risk factors KW - Hepatitis C KW - H 11000:Diseases/Injuries/Trauma KW - V 22005:AIDS: Epidemiological aspects KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21044598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=HIV%2C+hepatitis+C+and+HIV%2Fhepatitis+C+virus+co-infection+in+vulnerable+populations&rft.au=Backus%2C+LI%3BBoothroyd%2C+D%3BDeyton%2C+L+R&rft.aulast=Backus&rft.aufirst=LI&rft.date=2005-10-01&rft.volume=19&rft.issue=&rft.spage=S13&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Demography; Risk assessment; Mental disorders; Intravenous administration; Acquired immune deficiency syndrome; Depression; Antiviral agents; Risk factors; Hepatitis C; Drug abuse; Opportunist infection; Models; substance abuse; Hepatitis; Historical account; Alcohol; drug abuse; infectious diseases; Health care; Morbidity; Hepatitis C virus; Human immunodeficiency virus ER - TY - JOUR T1 - The threat of antibiotic resistance in Gram-negative pathogenic bacteria: beta -lactams in peril! AN - 20868238; 8336556 AB - beta -Lactam antibiotics are the cornerstone of our antibiotic armamentarium. By inhibiting bacterial cell wall synthesis, they are highly effective against Gram-positive and Gram-negative bacteria. Unfortunately, bacteria have evolved sophisticated resistance mechanisms to combat the lethal effects of beta -lactam antibiotics. Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae are all able to evade killing by penicillins, cephalosporins and carbapenems. This multi-drug resistant phenotype that challenges healthcare workers worldwide is caused by an array of resistance determinants. These include altered expression of outer membrane proteins and efflux pumps, along with an increasing arsenal of beta -lactamases. Future strategies in beta -lactam design must take into account the complex nature of resistance in Gram-negative pathogens. JF - Current Opinion in Microbiology AU - Thomson, Jodi M AU - Bonomo, Robert A AD - Department of Pharmacology, Case Western Reserve University School of Medicine and Department of Medicine, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA, robert.bonomo@med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 518 EP - 524 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 8 IS - 5 SN - 1369-5274, 1369-5274 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cephalosporins KW - beta -Lactamase KW - outer membrane proteins KW - Carbapenems KW - Antibiotics KW - Pathogens KW - Penicillin KW - Medical personnel KW - Acinetobacter baumannii KW - Reviews KW - Gram-negative bacteria KW - beta -Lactam antibiotics KW - Pseudomonas aeruginosa KW - Antibiotic resistance KW - Klebsiella pneumoniae KW - Cell walls KW - A 01340:Antibiotics & Antimicrobials KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20868238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Microbiology&rft.atitle=The+threat+of+antibiotic+resistance+in+Gram-negative+pathogenic+bacteria%3A+beta+-lactams+in+peril%21&rft.au=Thomson%2C+Jodi+M%3BBonomo%2C+Robert+A&rft.aulast=Thomson&rft.aufirst=Jodi&rft.date=2005-10-01&rft.volume=8&rft.issue=5&rft.spage=518&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Microbiology&rft.issn=13695274&rft_id=info:doi/10.1016%2Fj.mib.2005.08.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cephalosporins; outer membrane proteins; beta -Lactamase; Carbapenems; Antibiotics; Pathogens; Medical personnel; Penicillin; Gram-negative bacteria; Reviews; beta -Lactam antibiotics; Antibiotic resistance; Cell walls; Acinetobacter baumannii; Pseudomonas aeruginosa; Klebsiella pneumoniae DO - http://dx.doi.org/10.1016/j.mib.2005.08.014 ER - TY - JOUR T1 - ANTIINFECTANTS: Population pharmacokinetics of pyrazinamide in elephants AN - 20717363; 6555046 AB - This study was undertaken to characterize the population pharmacokinetics (PK), therapeutic dose, and preferred route of administration for pyrazinamide (PZA) in elephants. Twenty-three African (Loxodonta africana) and Asian (Elephas maximus) elephants infected with or in contact with others culture positive for Mycobacterium tuberculosis were dosed under treatment conditions. PZA was dosed daily at 20-30 mg/kg via oral (fasting or nonfasting state) or rectal (enema or suppository) administration. Blood samples were collected 0-24 h postdose. Population PK was estimated using nonlinear mixed effect modeling. Drug absorption was rapid with T sub(max) at or before 2 h regardless of the method of drug administration. C sub(max) at a mean dose of 25.6 ( plus or minus 4.6) mg/kg was 19.6 ( plus or minus 9.5 mu g/mL) for PZA given orally under fasting conditions. Under nonfasting conditions at a mean dose of 26.1 plus or minus 4.2 mg/kg, C sub(max) was 25% (4.87 plus or minus 4.89 mu g/mL) and area under concentration curve (AUC) was 30% of the values observed under fasting conditions. Mean rectal dose of 32.6 plus or minus 15.2 mg/kg yielded C sub(max) of 12.3 plus or minus 6.3 mu g/mL, but comparable AUC to PZA administered orally while fasting. Both oral and rectal administration of PZA appeared to be acceptable and oral dosing is preferred because of the higher C sub(max) and lower inter-subject variability. A starting dose of 30 mg/kg is recommended with drug monitoring between 1 and 2 h postdose. Higher doses may be required if the achieved C sub(max) values are below the recommended 20-50 mu g/mL range. JF - Journal of Veterinary Pharmacology and Therapeutics AU - Zhu, M AU - Maslow, J N AU - Mikota, S K AU - Isaza, R AU - Dunker, F AU - Riddle, H AU - Peloquin, CA AD - Section of Infectious Diseases, VA Medical Center and the Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA, USA, joel.maslow@med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 403 EP - 409 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 28 IS - 5 SN - 0140-7783, 0140-7783 KW - Microbiology Abstracts B: Bacteriology KW - Elephas maximus KW - Rectum KW - Loxodonta africana KW - Elephantidae KW - pyrazinamide KW - Fasting KW - Drugs KW - Pharmacokinetics KW - Mycobacterium tuberculosis KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20717363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.atitle=ANTIINFECTANTS%3A+Population+pharmacokinetics+of+pyrazinamide+in+elephants&rft.au=Zhu%2C+M%3BMaslow%2C+J+N%3BMikota%2C+S+K%3BIsaza%2C+R%3BDunker%2C+F%3BRiddle%2C+H%3BPeloquin%2C+CA&rft.aulast=Zhu&rft.aufirst=M&rft.date=2005-10-01&rft.volume=28&rft.issue=5&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.issn=01407783&rft_id=info:doi/10.1111%2Fj.1365-2885.2005.00670.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - SuppNotes - Figures, 5; tables, 1. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Rectum; pyrazinamide; Fasting; Drugs; Pharmacokinetics; Elephas maximus; Loxodonta africana; Elephantidae; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1111/j.1365-2885.2005.00670.x ER - TY - JOUR T1 - The Art of Prescribing. Mitigating Cutaneous Side Effects of Lamotrigine AN - 20236214; 6564530 JF - Perspectives in Psychiatric Care AU - Antai-Otong, Deborah Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 193 EP - 196 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 41 IS - 4 SN - 0031-5990, 0031-5990 KW - Toxicology Abstracts KW - lamotrigine KW - Side effects KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20236214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+in+Psychiatric+Care&rft.atitle=The+Art+of+Prescribing.+Mitigating+Cutaneous+Side+Effects+of+Lamotrigine&rft.au=Antai-Otong%2C+Deborah&rft.aulast=Antai-Otong&rft.aufirst=Deborah&rft.date=2005-10-01&rft.volume=41&rft.issue=4&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Perspectives+in+Psychiatric+Care&rft.issn=00315990&rft_id=info:doi/10.1111%2Fj.1744-6163.2005.00041.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - SuppNotes - Tables, 1; references, 14. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - lamotrigine; Side effects DO - http://dx.doi.org/10.1111/j.1744-6163.2005.00041.x ER - TY - JOUR T1 - Molecular Basis of Reduced Potency of Underacylated Endotoxins AN - 19933288; 6528252 AB - Potent TLR4-dependent cell activation by Gram-negative bacterial endotoxins depends on sequential endotoxin-protein and protein-protein interactions with LPS-binding protein, CD14, myeloid differentiation protein 2 (MD-2), and TLR4. Previous studies have suggested that reduced agonist potency of underacylated endotoxins (i.e., tetra- or penta- vs hexa-acylated) is determined by post-CD14 interactions. To better define the molecular basis of the differences in agonist potency of endotoxins differing in fatty acid acylation, we compared endotoxins (lipooligosaccharides (LOS)) from hexa-acylated wild-type (wt), penta-acylated mutant msbB meningococcal strains as well as tetra-acylated LOS generated by treatment of wt LOS with the deacylating enzyme, acyloxyacylhydrolase. To facilitate assay of endotoxin:protein and endotoxin:cell interactions, the endotoxins were purified after metabolic labeling with [ super(3)H]- or [ super(14)C]acetate. All LOS species tested formed monomeric complexes with MD-2 in an LPS-binding protein- and CD14-dependent manner with similar efficiency. However, msbB LOS:MD-2 and acyloxyacylhydrolase-treated LOS:MD-2 were at least 10-fold less potent in inducing TLR4-dependent cell activation than wt LOS:MD-2 and partially antagonized the action of wt LOS:MD-2. These findings suggest that underacylated endotoxins produce decreased TLR4-dependent cell activation by altering the interaction of the endotoxin:MD-2 complex with TLR4 in a way that reduces receptor activation. Differences in potency among these endotoxin species is determined not by different aggregate properties, but by different properties of monomeric endotoxin:MD-2 complexes. JF - Journal of Immunology AU - Teghanemt, Athmane AU - Zhang, DeSheng AU - Levis, Erika N AU - Weiss, Jerrold P AU - Gioannini, Theresa L AD - Inflammation Program, Departments of Internal Medicine, Department of Biochemistry, Coralville, IA 52241. Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, and Veterans Administration Medical Center, Iowa City, IA 52241 Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 4669 EP - 4676 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 175 IS - 7 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Endotoxins KW - Receptor mechanisms KW - Enzymes KW - Neisseria meningitidis KW - Acylation KW - CD14 antigen KW - Lipooligosaccharides KW - Cell activation KW - Differentiation KW - LPS-binding protein KW - Fatty acids KW - TLR4 protein KW - Protein interaction KW - Toll-like receptors KW - A 01490:Miscellaneous KW - F 06106:Bacteria KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19933288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Molecular+Basis+of+Reduced+Potency+of+Underacylated+Endotoxins&rft.au=Teghanemt%2C+Athmane%3BZhang%2C+DeSheng%3BLevis%2C+Erika+N%3BWeiss%2C+Jerrold+P%3BGioannini%2C+Theresa+L&rft.aulast=Teghanemt&rft.aufirst=Athmane&rft.date=2005-10-01&rft.volume=175&rft.issue=7&rft.spage=4669&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Endotoxins; Receptor mechanisms; Enzymes; Acylation; CD14 antigen; Cell activation; Lipooligosaccharides; Differentiation; Fatty acids; LPS-binding protein; TLR4 protein; Toll-like receptors; Protein interaction; Neisseria meningitidis ER - TY - JOUR T1 - In Vitro Activities of Doripenem and Comparator Agents against 364 Anaerobic Clinical Isolates AN - 17661122; 6505836 AB - The in vitro activities of doripenem against 364 anaerobic isolates were measured and compared to those of ertapenem, imipenem, meropenem, ceftriaxone, and levofloxacin. All of the carbapenems were active against nearly all Bacteroides fragilis group isolates. Doripenem was either comparable to or slightly less active than imipenem and meropenem against most isolates but more active than the other penems against Clostridium difficile. Doripenem appears to have excellent activity against a broad range of anaerobes. JF - Antimicrobial Agents & Chemotherapy AU - Wexler, Hannah M AU - Engel, Adrian E AU - Glass, Daniel AU - Li, Calida AD - Medical and Research Services, Greater Los Angeles Veterans Administration Health Care Services, Los Angeles, California. Department of Medicine, UCLA School of Medicine, Los Angeles, California Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 4413 EP - 4417 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 49 IS - 10 SN - 0066-4804, 0066-4804 KW - Doripenem KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - A 01066:Antibacterial & bactericidal KW - J 02812:Antibacterial Agents: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17661122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+Vitro+Activities+of+Doripenem+and+Comparator+Agents+against+364+Anaerobic+Clinical+Isolates&rft.au=Wexler%2C+Hannah+M%3BEngel%2C+Adrian+E%3BGlass%2C+Daniel%3BLi%2C+Calida&rft.aulast=Wexler&rft.aufirst=Hannah&rft.date=2005-10-01&rft.volume=49&rft.issue=10&rft.spage=4413&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-12-01 N1 - Last updated - 2011-12-13 ER - TY - CPAPER T1 - In Vitro Activity of DX-619 and Four Comparator Agents Against 376 Anaerobic Bacterial Isolates T2 - 45th Interscience Conference on Antimicrobial Agents and Chemotherapy AN - 39981008; 3986852 JF - 45th Interscience Conference on Antimicrobial Agents and Chemotherapy AU - Finegold Y1 - 2005/09/21/ PY - 2005 DA - 2005 Sep 21 KW - Antimicrobial agents KW - Chemotherapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39981008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy&rft.atitle=In+Vitro+Activity+of+DX-619+and+Four+Comparator+Agents+Against+376+Anaerobic+Bacterial+Isolates&rft.au=Finegold&rft.aulast=Finegold&rft.aufirst=&rft.date=2005-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Aspirin use in chronic heart failure: what should we recommend to the practitioner? AN - 68592346; 16168276 AB - There has been ongoing controversy as to whether aspirin should be used in patients with chronic heart failure (CHF). The argument for aspirin is that many patients have underlying coronary disease, and aspirin prevents reinfarction and other vascular events. Arguments against the routine use of aspirin are that many CHF patients do not have underlying coronary disease, and that the benefit of aspirin lessens after the first 6 to 12 months after infarction. Also, several analyses suggest that aspirin may actually worsen outcomes in CHF patients, possibly because it inhibits prostaglandins, with resulting adverse hemodynamic and renal effects. Two recent prospective randomized studies have found that aspirin is associated with more frequent hospitalizations for worsening heart failure, although it did not have an adverse effect on vascular events. These results suggest that aspirin should not be routinely used in CHF patients and be avoided in those with refractory CHF, but that it may be beneficial in patients with recent infarction or multiple vascular risk factors. JF - Journal of the American College of Cardiology AU - Massie, Barry M AD - Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California, USA. barry.massie@med.va.gov Y1 - 2005/09/20/ PY - 2005 DA - 2005 Sep 20 SP - 963 EP - 966 VL - 46 IS - 6 KW - Platelet Aggregation Inhibitors KW - 0 KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Practice Guidelines as Topic KW - Chronic Disease KW - Platelet Aggregation Inhibitors -- adverse effects KW - Platelet Aggregation Inhibitors -- therapeutic use KW - Heart Failure -- drug therapy KW - Aspirin -- adverse effects KW - Aspirin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68592346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Aspirin+use+in+chronic+heart+failure%3A+what+should+we+recommend+to+the+practitioner%3F&rft.au=Massie%2C+Barry+M&rft.aulast=Massie&rft.aufirst=Barry&rft.date=2005-09-20&rft.volume=46&rft.issue=6&rft.spage=963&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=1558-3597&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-22 N1 - Date created - 2005-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - MRI Confirms Mild Cognitive Impairment Prodromal for Different Dementias T2 - 9th Congress of the European Federation of Neurological Societies (EFNS 2005) AN - 39704997; 4019257 JF - 9th Congress of the European Federation of Neurological Societies (EFNS 2005) AU - Meyer, J S AU - Huang, J AU - Chowdhury, M H Y1 - 2005/09/17/ PY - 2005 DA - 2005 Sep 17 KW - Magnetic resonance imaging KW - Cognitive ability KW - Dementia disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39704997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+Congress+of+the+European+Federation+of+Neurological+Societies+%28EFNS+2005%29&rft.atitle=MRI+Confirms+Mild+Cognitive+Impairment+Prodromal+for+Different+Dementias&rft.au=Meyer%2C+J+S%3BHuang%2C+J%3BChowdhury%2C+M+H&rft.aulast=Meyer&rft.aufirst=J&rft.date=2005-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+Congress+of+the+European+Federation+of+Neurological+Societies+%28EFNS+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/efns2005/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Application of a disease-specific mapping function to estimate utility gains with effective treatment of schizophrenia. AN - 68695175; 16153308 AB - Most tools for estimating utilities use clinical trial data from general health status models, such as the 36-Item Short-Form Health Survey (SF-36). A disease-specific model may be more appropriate. The objective of this study was to apply a disease-specific utility mapping function for schizophrenia to data from a large, 1-year, open-label study of long-acting risperidone and to compare its performance with an SF-36-based utility mapping function. Patients with schizophrenia or schizoaffective disorder by DSM-IV criteria received 25, 50, or 75 mg long-acting risperidone every 2 weeks for 12 months. The Positive and Negative Syndrome Scale (PANSS) and SF-36 were used to assess efficacy and health-related quality of life. Movement disorder severity was measured using the Extrapyramidal Symptom Rating Scale (ESRS); data concerning other common adverse effects (orthostatic hypotension, weight gain) were collected. Transforms were applied to estimate utilities. A total of 474 patients completed the study. Long-acting risperidone treatment was associated with a utility gain of 0.051 using the disease-specific function. The estimated gain using an SF-36-based mapping function was smaller: 0.0285. Estimates of gains were only weakly correlated (r = 0.2). Because of differences in scaling and variance, the requisite sample size for a randomized trial to confirm observed effects is much smaller for the disease-specific mapping function (156 versus 672 total subjects). Application of a disease-specific mapping function was feasible. Differences in scaling and precision suggest the clinically based mapping function has greater power than the SF-36-based measure to detect differences in utility. JF - Health and quality of life outcomes AU - Lenert, Leslie A AU - Rupnow, Marcia F T AU - Elnitsky, Christine AD - Veterans Administration San Diego Health Care System, San Diego, California, USA. llenert@ucsd.edu Y1 - 2005/09/11/ PY - 2005 DA - 2005 Sep 11 SP - 57 VL - 3 KW - Antipsychotic Agents KW - 0 KW - Delayed-Action Preparations KW - Risperidone KW - L6UH7ZF8HC KW - Index Medicus KW - Administration, Oral KW - Psychiatric Status Rating Scales KW - Humans KW - Adult KW - Quality of Life KW - Middle Aged KW - Male KW - Female KW - Antipsychotic Agents -- therapeutic use KW - Risperidone -- administration & dosage KW - Schizophrenia -- diagnosis KW - Schizophrenia -- physiopathology KW - Antipsychotic Agents -- administration & dosage KW - Sickness Impact Profile KW - Outcome Assessment (Health Care) -- methods KW - Schizophrenia -- drug therapy KW - Risperidone -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Psychotic Disorders -- diagnosis KW - Risperidone -- therapeutic use KW - Psychotic Disorders -- physiopathology KW - Psychotic Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68695175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+and+quality+of+life+outcomes&rft.atitle=Application+of+a+disease-specific+mapping+function+to+estimate+utility+gains+with+effective+treatment+of+schizophrenia.&rft.au=Lenert%2C+Leslie+A%3BRupnow%2C+Marcia+F+T%3BElnitsky%2C+Christine&rft.aulast=Lenert&rft.aufirst=Leslie&rft.date=2005-09-11&rft.volume=3&rft.issue=&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Health+and+quality+of+life+outcomes&rft.issn=1477-7525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-31 N1 - Date created - 2005-10-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Med Decis Making. 2003 Jan-Feb;23(1):67-75 [12583456] Med Care. 2003 Feb;41(2):208-17 [12555049] JAMA. 2003 Nov 26;290(20):2693-702 [14645311] J Clin Psychiatry. 2003 Oct;64(10):1250-7 [14658976] Med Care. 2004 Feb;42(2):183-96 [14734956] Med Care. 2004 Sep;42(9):851-9 [15319610] Med Care. 2004 Sep;42(9):927-37 [15319619] Schizophr Res. 2004 Nov 1;71(1):83-95 [15374576] Schizophr Res. 2004 Nov 1;71(1):155-65 [15374583] Br J Psychiatry Suppl. 1989 Nov;(7):59-67 [2619982] Med Care. 1992 Jun;30(6):473-83 [1593914] Med Care. 1996 Mar;34(3):220-33 [8628042] Med Care. 1996 Jul;34(7):702-22 [8676608] Med Decis Making. 1997 Jan-Mar;17(1):1-9 [8994146] Pharmacoeconomics. 1997 Feb;11(2):159-68 [10172935] N Engl J Med. 1997 Sep 18;337(12):809-15 [9295240] BMJ. 1998 Mar 7;316(7133):736-41 [9529408] Health Serv Res. 1998 Dec;33(5 Pt 1):1237-61 [9865219] Int J Qual Health Care. 1998 Dec;10(6):509-20 [9928590] J Affect Disord. 2004 Dec;83(2-3):263-75 [15555724] Med Care. 2000 Jul;38(7):763-70 [10901359] Med Decis Making. 2001 Mar-Apr;21(2):105-12 [11310943] Ann Med. 2001 Jul;33(5):375-84 [11491197] Med Care. 2001 Nov;39(11):1246-59 [11606878] J Health Econ. 2002 Mar;21(2):271-92 [11939242] Proc AMIA Symp. 2002;:440-4 [12463862] Qual Life Res. 2003 Jun;12(4):363-71 [12797709] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of work hour reduction on residents' lives: a systematic review. AN - 68557789; 16145030 AB - The Accreditation Council for Graduate Medical Education implemented mandatory work hour limitations in July 2003, partly out of concern for residents' well-being in the setting of sleep deprivation. These limitations are likely to also have an impact on other aspects of the lives of residents. To summarize the literature regarding the effect of interventions to reduce resident work hours on residents' education and quality of life. We searched the English-language literature about resident work hours from 1966 through April 2005 using MEDLINE, EMBASE, and Current Contents, supplemented with hand-search of additional journals, reference list review, and review of abstracts from national meetings. Studies were included that assessed a system change designed to counteract the effects of resident work hours, fatigue, or sleep deprivation; included an outcome directly related to residents; and were conducted in the United States. For each included study, 2 investigators independently abstracted data related to study quality, subjects, interventions, and findings using a standard data abstraction form. Fifty-four articles met inclusion criteria. The interventions used to decrease resident work hours varied but included night and day float teams, extra cross-coverage, and physician extenders. Outcomes included measures of resident education (operative experience, test scores, satisfaction) and quality of residents' lives (amount of sleep, well-being). Interventions to reduce resident work hours resulted in mixed effects on both operative experience and on perceived educational quality but generally improved residents' quality of life. Many studies had major limitations in their design or conduct. Past interventions suggest that residents' quality of life may improve with work hour limitations, but interpretation of the outcomes of these studies is hampered by suboptimal study design and the use of nonvalidated instruments. The long-term impact of reducing resident work hours on education remains unknown. Current and future interventions should be evaluated with more rigorous methods and should investigate links between residents' quality of life and quality of patient care. JF - JAMA AU - Fletcher, Kathlyn E AU - Underwood, Willie AU - Davis, Steven Q AU - Mangrulkar, Rajesh S AU - McMahon, Laurence F AU - Saint, Sanjay AD - Department of Internal Medicine, Clement J. Zablocki VA Medical Center/Medical College of Wisconsin, Milwaukee 53295, USA. kathlyn.fletcher@med.va.gov Y1 - 2005/09/07/ PY - 2005 DA - 2005 Sep 07 SP - 1088 EP - 1100 VL - 294 IS - 9 KW - Abridged Index Medicus KW - Index Medicus KW - Education, Medical KW - Sleep Disorders, Circadian Rhythm KW - Fatigue KW - Humans KW - Specialization KW - Work Schedule Tolerance KW - Workload KW - Internship and Residency KW - Quality of Life UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68557789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Effects+of+work+hour+reduction+on+residents%27+lives%3A+a+systematic+review.&rft.au=Fletcher%2C+Kathlyn+E%3BUnderwood%2C+Willie%3BDavis%2C+Steven+Q%3BMangrulkar%2C+Rajesh+S%3BMcMahon%2C+Laurence+F%3BSaint%2C+Sanjay&rft.aulast=Fletcher&rft.aufirst=Kathlyn&rft.date=2005-09-07&rft.volume=294&rft.issue=9&rft.spage=1088&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=1538-3598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-12 N1 - Date created - 2005-09-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: JAMA. 2005 Sep 7;294(9):1104-6 [16145032] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interstitial lung disease following erlotinib (Tarceva) in a patient who previously tolerated gefitinib (Iressa). AN - 69054755; 16390601 AB - To report a case of who a patient developed clinical and radiographical evidence of interstitial lung disease (ILD) on erlotinib after having tolerated gefitinib therapy. A 58-year-old man with stage IV non-small-cell lung cancer (NSCLC) failed first and second line chemotherapy. He then received gefitinib, a small molecule epidermal growth factor receptor (EGFR) inhibitor, a therapy which was well tolerated, but did cause a grade 1 rash. On gefitinib, the patient's disease remained stable for seven months. Subsequent disease progression was treated with the newer EGFR inhibitor, erlotinib. After 5 days of erlotinib therapy, the patient presented with a sore throat and dyspnea, followed by a grade 2 rash and significant hemoptysis. Erlotinib was discontinued for three days, during which time his symptoms abated. Erlotinib was restarted and the patient again developed sore throat, dyspnea and severe hemotpysis, with progression of the rash to grade 3. Erlotinib therapy was discontinued and the patient recevied prednisone and supplemental oxygen. A CT scan of the chest demonstrated new areas of patchy ground glass opacity bilaterally and increased interstitial markings consistent with ILD. The case demonstrates that clinical ILD can occur following erlotinib therapy, even in patients who previously tolerated gefitinib. ILD has not been reported to occur more frequently with erlotinib than with gefitinib. However, the dose of erlotinib employed clinically is the maximum tolerated dose identified in phase 1 trials, and is associated with an increased incidence of grade 3-4 rash and diarrhea, as compared to gefitinib. Thus, the observation of clinical ILD following erlotinib, but not gefitinib, may be the consequence of increased potency of erlotinib 150 mg/day compared to gefitinib 250 mg/day. Clinical ILD can occur following erlotinib even in patients who previously tolerated gefitinib. IT is important to carefully monitor pulmonary symptoms in all patients who are receiving erlotinib, as early diagnosis and timely intervention are critical in managing drug-induced ILD. JF - Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners AU - Tammaro, Kelly A AU - Baldwin, Patricia D AU - Lundberg, Ante S AD - Boston VA Health Care System, MA 02130, USA. Tammaro@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 127 EP - 130 VL - 11 IS - 3 SN - 1078-1552, 1078-1552 KW - Protein Kinase Inhibitors KW - 0 KW - Quinazolines KW - Erlotinib Hydrochloride KW - DA87705X9K KW - gefitinib KW - S65743JHBS KW - Index Medicus KW - Humans KW - Tomography, X-Ray Computed KW - Middle Aged KW - Male KW - Protein Kinase Inhibitors -- adverse effects KW - Lung Neoplasms -- drug therapy KW - Lung Diseases, Interstitial -- diagnostic imaging KW - Quinazolines -- therapeutic use KW - Quinazolines -- adverse effects KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Lung Diseases, Interstitial -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69054755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Tinea+corporis+gladiatorum&rft.au=Adams%2C+B+B&rft.aulast=Adams&rft.aufirst=B&rft.date=2002-01-01&rft.volume=47&rft.issue=&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=01909622&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-26 N1 - Date created - 2006-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Word recognition in multitalker babble measured with two psychophysical methods. AN - 68802208; 16295249 AB - The purpose of this experiment was to determine the relationship between psychometric functions for words presented in multitalker babble using a descending presentation level protocol and a random presentation level protocol. Forty veterans (mean = 63.5 years) with mild-to-moderate sensorineural hearing losses were enrolled. Seventy of the Northwestern University Auditory Test No. 6 words spoken by the VA female speaker were presented at seven signal-to-babble ratios from 24 to 0 dB (10 words/step). Although the random procedure required 69 sec longer to administer than the descending protocol, there was no significant difference between the results obtained with the two psychophysical methods. There was almost no relation between the perceived ability of the listeners to understand speech in background noise and their measured ability to understand speech in multitalker babble. Likewise, there was a tenuous relation between pure-tone thresholds and performance on the words in babble and between recognition performance in quiet and performance on the words in babble. JF - Journal of the American Academy of Audiology AU - Wilson, Richard H AU - Burks, Christopher A AU - Weakley, Deborah G AD - James H. Quillen VA Medical Center, Mountain Home, TN 37684, USA. RICHARD.WILSON2@MED.VA.GOV Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 622 EP - 630 VL - 16 IS - 8 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - Audiometry, Pure-Tone KW - Humans KW - Noise KW - Middle Aged KW - Psychometrics KW - Male KW - Speech Discrimination Tests -- methods KW - Hearing Loss, Sensorineural -- physiopathology KW - Speech Perception -- physiology KW - Perceptual Masking -- physiology KW - Hearing Loss, Sensorineural -- psychology KW - Self-Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68802208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Word+recognition+in+multitalker+babble+measured+with+two+psychophysical+methods.&rft.au=Wilson%2C+Richard+H%3BBurks%2C+Christopher+A%3BWeakley%2C+Deborah+G&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2005-09-01&rft.volume=16&rft.issue=8&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-17 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recent suicide attempt and the effectiveness of inpatient and outpatient substance use disorder treatment. AN - 68649724; 16205366 AB - The present study investigated whether or not the effect of treatment setting (inpatient or outpatient) on 6-mo follow-up substance use varied for suicidal and non-suicidal patients. In particular, the study tested the hypothesis that treatment setting would have no differing effect for non-suicidal participants, but for suicidal participants, inpatient setting would be more closely associated with positive outcomes than the outpatient setting. A national sample of patients presenting for treatment of substance use disorders in the Veterans Administration health care system was selected to participate in the study. A total of 1,289 participants provided complete data on psychiatric and substance-related problems at baseline and 6-mo follow-up. At baseline, 4% (n=53) of the sample reported having made a suicide attempt within the past 30 days. Those who reported a suicide attempt were no more likely to have been treated in an inpatient setting than in an outpatient setting. A significant interaction between baseline suicide attempt and treatment setting was found, such that non-suicidal patients reported similar patterns of substance use when treated in inpatient or outpatient settings, but suicidal patients were significantly more likely to have better substance-related outcomes at 6-mo follow-up if they were treated in inpatient compared with outpatient settings. Suicidal patients displayed substantial improvement after substance use disorders treatment and seem particularly responsive to treatment in inpatient settings. JF - Alcoholism, clinical and experimental research AU - Ilgen, Mark A AU - Tiet, Quyen AU - Finney, John W AU - Harris, Alex H S AD - Center for Health Care Evaluation, Department of Veterans Affairs, Palo Alto Health Care System and Stanford University School of Medicine, Menlo Park, California 94025, USA. Mark.Ilgen@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 1664 EP - 1671 VL - 29 IS - 9 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Outpatients KW - Humans KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Inpatients KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - Suicide, Attempted -- psychology KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68649724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Recent+suicide+attempt+and+the+effectiveness+of+inpatient+and+outpatient+substance+use+disorder+treatment.&rft.au=Ilgen%2C+Mark+A%3BTiet%2C+Quyen%3BFinney%2C+John+W%3BHarris%2C+Alex+H+S&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2005-09-01&rft.volume=29&rft.issue=9&rft.spage=1664&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-22 N1 - Date created - 2005-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol. AN - 68647847; 16205373 AB - This article represents the proceedings of a symposium at the 2004 RSA Meeting held in Vancouver, Canada. The chairs were Arthur I. Cederbaum and Raj Lakshman. The presentations were (1) ethanol regulates 2,6-sialyltransferase (2,6-ST) gene expression posttranscriptionally by the interaction of a cytosolic binding protein with 2,6-ST mRNA in CYP2E1- and ADH-transfected HepG2 cells, by Raj Lakshman; (2) nature versus nurture: HepG2-E47 cells as a tool to investigate mechanisms of ethanol-mediated potentiation of cell killing, by Jan B. Hoek; (3) ethanol up-regulates profibrogenic connective tissue growth factor gene expression in HepG2 cells via cytochrome P-450 2E1-mediated ethanol oxidation, by Masahiro Konishi; (4) role of calcium and calcium-activated enzymes in CYP2E1-dependent toxicity, by Arthur I Cederbaum; (5) the use of cell lines to characterize the role of CYP2E1 in the metabolism of farnesol, by Dennis Koop; and (6) studies with HepG2 cells that express the two major ethanol-metabolizing enzymes, by Terrence M. Donohue. JF - Alcoholism, clinical and experimental research AU - Lakshman, Raj AU - Cederbaum, Arthur I AU - Hoek, Jan B AU - Konishi, Masahiro AU - Koop, Dennis AU - Donohu, Terrence M AD - Lipid Research Laboratory, VA Medical Center, and the Department of Biochemistry, Molecular Biology, and Medicine, George Washington University, Washington, DC 20422, USA. raj.lakshman@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 1726 EP - 1734 VL - 29 IS - 9 SN - 0145-6008, 0145-6008 KW - CTGF protein, human KW - 0 KW - Immediate-Early Proteins KW - Intercellular Signaling Peptides and Proteins KW - Tumor Necrosis Factor-alpha KW - Connective Tissue Growth Factor KW - 139568-91-5 KW - Ethanol KW - 3K9958V90M KW - Farnesol KW - 4602-84-0 KW - Alcohol Dehydrogenase KW - EC 1.1.1.1 KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Sialyltransferases KW - EC 2.4.99.- KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Humans KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Intercellular Signaling Peptides and Proteins -- genetics KW - Oxidation-Reduction KW - Immediate-Early Proteins -- genetics KW - Sialyltransferases -- genetics KW - Transfection KW - Alcohol Dehydrogenase -- physiology KW - Calcium -- physiology KW - p38 Mitogen-Activated Protein Kinases -- physiology KW - Farnesol -- metabolism KW - Cell Line KW - Liver -- drug effects KW - Ethanol -- toxicity KW - Cytochrome P-450 CYP2E1 -- physiology KW - Ethanol -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68647847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Use+of+CYP2E1-transfected+human+liver+cell+lines+in+elucidating+the+actions+of+ethanol.&rft.au=Lakshman%2C+Raj%3BCederbaum%2C+Arthur+I%3BHoek%2C+Jan+B%3BKonishi%2C+Masahiro%3BKoop%2C+Dennis%3BDonohu%2C+Terrence+M&rft.aulast=Lakshman&rft.aufirst=Raj&rft.date=2005-09-01&rft.volume=29&rft.issue=9&rft.spage=1726&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-22 N1 - Date created - 2005-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antiretroviral therapy in HIV-positive men is associated with increased apolipoprotein CIII in triglyceride-rich lipoproteins. AN - 68580928; 16156880 AB - Dyslipidaemia has become a common problem in HIV disease, especially in patients on current antiretroviral therapy. However, the pathogenic mechanisms involved are not well understood or documented using conventional lipid measurements. Using a cross-sectional design, the prevalence of abnormal standard lipid measurements and novel biomarkers for abnormal lipid metabolism was determined in 271 HIV-positive men from two HIV clinics in Atlanta, GA, USA. A total of 147 men were treated with protease inhibitors (PIs) for >3 months (54%), 84 were treated with nonnucleoside reverse transcriptase inhibitors (NNRTIs) for >3 months (31%) and 40 had not received antiretroviral therapy in the past 3 months (15%). Patients being treated with a PI had higher total cholesterol and triglyceride (TG) levels than patients on no therapy (P<0.05 for each). Patients in the NNRTI group had higher TG, lower high-density lipoprotein (HDL) levels, and higher low-density lipoprotein (LDL) levels than patients on no therapy (P<0.05 for each). Patients treated with either PIs or NNRTIs were more likely to have higher apolipoprotein CIII (apoCIII) levels (P<0.05 for each) than patients on no therapy. Elevated TG was associated with disproportionably elevated apoCIII levels in both treatment groups. In this cross-sectional study of HIV-infected men, either PI or NNRTI therapy elevated levels of TG and apoCIII. Higher concentrations of apoCIII in apoB-containing lipoproteins [very low-density lipoproteins (VLDLs), intermediate density lipoprotein (IDL) and LDLs] have been predictive of an increased incidence of coronary events in clinical trials and more rapid progression of coronary lesions measured by angiography. These findings, on a background of an older population with additional risk factors of smoking and diabetes, portend future atherosclerotic events in these patients. JF - HIV medicine AU - Rimland, D AU - Guest, J L AU - Hernández, I AU - Del Rio, C AU - Le, N A AU - Brown, W V AD - Atlanta VA Medical Center, Atlanta, GA 30033, USA. david.rimland@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 326 EP - 333 VL - 6 IS - 5 SN - 1464-2662, 1464-2662 KW - Anti-HIV Agents KW - 0 KW - Apolipoprotein C-III KW - Apolipoproteins C KW - HIV Protease Inhibitors KW - Reverse Transcriptase Inhibitors KW - Triglycerides KW - Index Medicus KW - Reverse Transcriptase Inhibitors -- adverse effects KW - Cross-Sectional Studies KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - HIV Protease Inhibitors -- therapeutic use KW - Reverse Transcriptase Inhibitors -- therapeutic use KW - HIV Protease Inhibitors -- adverse effects KW - Male KW - Triglycerides -- blood KW - Dyslipidemias -- blood KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- blood KW - HIV Infections -- drug therapy KW - Anti-HIV Agents -- adverse effects KW - Apolipoproteins C -- blood KW - Dyslipidemias -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68580928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=HIV+medicine&rft.atitle=Antiretroviral+therapy+in+HIV-positive+men+is+associated+with+increased+apolipoprotein+CIII+in+triglyceride-rich+lipoproteins.&rft.au=Rimland%2C+D%3BGuest%2C+J+L%3BHern%C3%A1ndez%2C+I%3BDel+Rio%2C+C%3BLe%2C+N+A%3BBrown%2C+W+V&rft.aulast=Rimland&rft.aufirst=D&rft.date=2005-09-01&rft.volume=6&rft.issue=5&rft.spage=326&rft.isbn=&rft.btitle=&rft.title=HIV+medicine&rft.issn=14642662&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-06 N1 - Date created - 2005-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Biomechanical evaluation of kyphoplasty with calcium sulfate cement in a cadaveric osteoporotic vertebral compression fracture model. AN - 68575092; 16153574 AB - Vertebral compression fractures can cause deformity, pain, and disability. Kyphoplasty involves percutaneous insertion of an inflatable balloon tamp into a fractured vertebra followed by injection of polymethylmethacrylate (PMMA) bone cement. PMMA has several disadvantages such as potential thermal necrosis and monomer toxicity. Calcium sulfate cement (CSC) is nontoxic, osteoconductive, and bioabsorbable. To evaluate the biomechanical performance of CSC for kyphoplasty in cadaveric osteoporotic vertebral bodies. Destructive biomechanical tests using fresh cadaveric thoracolumbar vertebral bodies. Thirty-three vertebral bodies (T9 to L4) from osteoporotic cadaveric spines were disarticulated, stripped of soft tissue, and measured for height and volume. Each vertebral body was compressed at 0.5 mm/s using a hinged plating system on a materials testing machine to create an anterior wedge fracture and reduce the anterior height by 25%. Pretreatment strength and stiffness were measured. Two KyphX inflatable balloon tamps were used to reexpand each vertebral body. After randomization, three groups were created: Group A-no cement; Group B-PMMA; Group C-calcium sulfate cement. Groups B and C were filled with the corresponding cement to 25% of the vertebral body volume. All vertebral bodies were then recompressed by 25% of the post-kyphoplasty anterior height to obtain posttreatment strength and stiffness. Treatment with PMMA restored vertebral strength to 127% of the intact level (4168.2 N+/-2288.7) and stiffness to 70% of the intact level (810.0 N/mm+/-380.6). Treatment with CSC restored strength to 108% of the intact level (3429.6 N+/-2440.7) and stiffness to 46% of the intact level (597.7 N/mm+/-317.5). CSC and PMMA were not significantly different for strength restoration (p=.4). Significantly greater strength restoration was obtained with either PMMA or CSC, compared with the control group (p=.003 and .03, respectively). Stiffness restoration tended to be greater with PMMA than for CSC, but this difference was not statistically significant (p=.1). Both cements had significantly greater stiffness when compared with the control group (p=.001 and p=.04, respectively). Use of CSC for kyphoplasty yields similar vertebral body strength and stiffness as compared with PMMA. It may be a useful alternative bone cement for kyphoplasty. Further studies are required to assess the bioabsorption of CSCs after kyphoplasty in vivo. JF - The spine journal : official journal of the North American Spine Society AU - Perry, Andrew AU - Mahar, Andrew AU - Massie, Jennifer AU - Arrieta, Noemi AU - Garfin, Steven AU - Kim, Choll AD - Veterans Administration and University of California, San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, USA. PY - 2005 SP - 489 EP - 493 VL - 5 IS - 5 SN - 1529-9430, 1529-9430 KW - Bone Cements KW - 0 KW - Polymethyl Methacrylate KW - 9011-14-7 KW - Calcium Sulfate KW - WAT0DDB505 KW - Index Medicus KW - Cadaver KW - Aged, 80 and over KW - Humans KW - Biomechanical Phenomena KW - In Vitro Techniques KW - Aged KW - Male KW - Female KW - Thoracic Vertebrae -- injuries KW - Lumbar Vertebrae -- injuries KW - Fractures, Compression -- therapy KW - Spinal Fractures -- physiopathology KW - Thoracic Vertebrae -- physiopathology KW - Lumbar Vertebrae -- physiopathology KW - Calcium Sulfate -- administration & dosage KW - Spinal Fractures -- therapy KW - Osteoporosis -- complications KW - Fractures, Compression -- physiopathology KW - Fractures, Compression -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68575092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+spine+journal+%3A+official+journal+of+the+North+American+Spine+Society&rft.atitle=Biomechanical+evaluation+of+kyphoplasty+with+calcium+sulfate+cement+in+a+cadaveric+osteoporotic+vertebral+compression+fracture+model.&rft.au=Perry%2C+Andrew%3BMahar%2C+Andrew%3BMassie%2C+Jennifer%3BArrieta%2C+Noemi%3BGarfin%2C+Steven%3BKim%2C+Choll&rft.aulast=Perry&rft.aufirst=Andrew&rft.date=2005-09-01&rft.volume=5&rft.issue=5&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=The+spine+journal+%3A+official+journal+of+the+North+American+Spine+Society&rft.issn=15299430&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-24 N1 - Date created - 2005-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pilot evaluation of pulse itraconazole vs. terbinafine for treatment of Candida toenail onychomycosis. AN - 68544421; 16135154 JF - International journal of dermatology AU - Warshaw, Erin M AU - Nelson, David AU - Carver, Susan M AU - Zielke, Gary R AU - Webster, Nancy AU - Lederle, Frank A AU - Fett, Debra D AD - University of Minnesota, Minneapolis, MN, USA. erin.warshaw@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 785 EP - 788 VL - 44 IS - 9 SN - 0011-9059, 0011-9059 KW - Antifungal Agents KW - 0 KW - Naphthalenes KW - Itraconazole KW - 304NUG5GF4 KW - terbinafine KW - G7RIW8S0XP KW - Index Medicus KW - Antifungal Agents -- adverse effects KW - Dose-Response Relationship, Drug KW - Humans KW - Aged KW - Gastrointestinal Diseases -- chemically induced KW - Pilot Projects KW - Pruritus -- chemically induced KW - Candida -- isolation & purification KW - Antifungal Agents -- therapeutic use KW - Candida -- drug effects KW - Antifungal Agents -- pharmacology KW - Aged, 80 and over KW - Patient Dropouts KW - Treatment Outcome KW - Middle Aged KW - Species Specificity KW - Microbial Sensitivity Tests KW - Female KW - Male KW - Naphthalenes -- therapeutic use KW - Naphthalenes -- pharmacology KW - Candidiasis -- microbiology KW - Candidiasis -- drug therapy KW - Itraconazole -- therapeutic use KW - Itraconazole -- pharmacology KW - Naphthalenes -- adverse effects KW - Itraconazole -- adverse effects KW - Foot Dermatoses -- drug therapy KW - Onychomycosis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68544421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+dermatology&rft.atitle=A+pilot+evaluation+of+pulse+itraconazole+vs.+terbinafine+for+treatment+of+Candida+toenail+onychomycosis.&rft.au=Warshaw%2C+Erin+M%3BNelson%2C+David%3BCarver%2C+Susan+M%3BZielke%2C+Gary+R%3BWebster%2C+Nancy%3BLederle%2C+Frank+A%3BFett%2C+Debra+D&rft.aulast=Warshaw&rft.aufirst=Erin&rft.date=2005-09-01&rft.volume=44&rft.issue=9&rft.spage=785&rft.isbn=&rft.btitle=&rft.title=International+journal+of+dermatology&rft.issn=00119059&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-21 N1 - Date created - 2005-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. AN - 68511512; 15878913 AB - For the past 60 years, dietary intake of essential fatty acids has increased. Moreover, the omega-6 fatty acids have recently been found to play an important role in regulation of gene expression. Proliferation of human prostate cells was significantly increased 48 h after arachidonic acid (AA) addition. We have analyzed initial uptake using nile red fluorescence and we found that the albumin conjugated AA is endocytosed into the cells followed by the induction of RNA within minutes, protein and PGE2 synthesis within hours. Here we describe that AA induces expression of cytosolic phospholipase A2 (cPLA2) in a dose-dependent manner and that this upregulation is dependent upon downstream synthesis of PGE2. The upregulation of cox-2 and cPLA2 was inhibited by flurbiprofen, a cyclooxygenase (COX) inhibitor, making this a second feed-forward enzyme in the eicosanoid pathway. Cox-2 specific inhibitors are known to inhibit colon and prostate cancer growth in humans; however, recent findings show that some of these have cardiovascular complications. Since cPLA2 is upstream in the eicosanoid pathway, it may be a good alternative for a pharmaceutical target for the treatment of cancer. JF - Carcinogenesis AU - Hughes-Fulford, Millie AU - Tjandrawinata, Raymond R AU - Li, Chai-Fei AU - Sayyah, Sina AD - Laboratory of Cell Growth, Mail Code 151F, Department of Medicine, Northern California Institute for Research and Education and Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA. millie.hughes-fulford@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 1520 EP - 1526 VL - 26 IS - 9 SN - 0143-3334, 0143-3334 KW - Membrane Proteins KW - 0 KW - Proto-Oncogene Proteins c-fos KW - RNA, Messenger KW - Arachidonic Acid KW - 27YG812J1I KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Phospholipases A KW - EC 3.1.1.32 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Index Medicus KW - Space life sciences KW - NASA Discipline Cell Biology KW - Non-NASA Center KW - Humans KW - Cell Line, Tumor KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Gene Expression Regulation, Neoplastic KW - Promoter Regions, Genetic KW - Gene Expression Regulation, Enzymologic KW - Enzyme Induction -- drug effects KW - Proto-Oncogene Proteins c-fos -- genetics KW - Prostatic Neoplasms -- enzymology KW - Prostaglandin-Endoperoxide Synthases -- genetics KW - Cytoplasm -- enzymology KW - Male KW - Cell Division KW - Phospholipases A -- genetics KW - Arachidonic Acid -- pharmacology KW - Arachidonic Acid -- pharmacokinetics KW - Phospholipases A -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68511512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Arachidonic+acid%2C+an+omega-6+fatty+acid%2C+induces+cytoplasmic+phospholipase+A2+in+prostate+carcinoma+cells.&rft.au=Hughes-Fulford%2C+Millie%3BTjandrawinata%2C+Raymond+R%3BLi%2C+Chai-Fei%3BSayyah%2C+Sina&rft.aulast=Hughes-Fulford&rft.aufirst=Millie&rft.date=2005-09-01&rft.volume=26&rft.issue=9&rft.spage=1520&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-07 N1 - Date created - 2005-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Capecitabine-warfarin interaction. AN - 68479632; 16014372 AB - To report a case of concomitant warfarin therapy with consecutive cycles of capecitabine therapy, providing time of onset, magnitude, and assessment of the interaction. A 59-year-old man receiving chronic warfarin therapy for a mechanical mitral valve replacement was diagnosed with stage IV metastatic colon cancer. He was started on capecitabine/irinotecan after his cancer progressed with fluorouracil/leucovorin and the FOLFOX 6 regimen (oxaliplatin, leucovorin, and continuous fluorouracil infusion). He received 3 consecutive cycles of capecitabine/irinotecan with concomitant oral anticoagulation and, with each cycle, the warfarin dose was reduced. Over the course of these 3 cycles, the total weekly dose of warfarin was reduced by >85%. The capecitabine-warfarin interaction is clinically significant, requiring a black box warning in the package insert. The mechanism of action for the interaction is not clear, but may be related to down-regulation of CYP2C9 by capecitabine or its metabolites or a pharmacodynamic interaction with warfarin. A common response to this interaction, as discussed in previously published case reports, is the discontinuation of warfarin, capecitabine, or both. In this case, the Naranjo probability scale indicates a highly probable drug interaction between warfarin and capecitabine. As more patients require anticoagulation, and as chemotherapy agents such as capecitabine become available, the likelihood for these drug interactions increases. In our patient, close monitoring of therapy allowed successful use of warfarin and capecitabine. JF - The Annals of pharmacotherapy AU - Janney, Laurel M AU - Waterbury, Nancee V AD - Department of Pharmacy Service, Iowa City Veterans Affairs Medical Center, Iowa City, IA 52246-2208, USA. Laurel.Janney@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 1546 EP - 1551 VL - 39 IS - 9 SN - 1060-0280, 1060-0280 KW - Anticoagulants KW - 0 KW - Antimetabolites, Antineoplastic KW - Deoxycytidine KW - 0W860991D6 KW - Warfarin KW - 5Q7ZVV76EI KW - Capecitabine KW - 6804DJ8Z9U KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Heart Valve Prosthesis Implantation KW - Drug Interactions KW - Colonic Neoplasms -- complications KW - Mitral Valve -- surgery KW - Humans KW - International Normalized Ratio KW - Fluorouracil -- analogs & derivatives KW - Colonic Neoplasms -- drug therapy KW - Middle Aged KW - Male KW - Deoxycytidine -- adverse effects KW - Antimetabolites, Antineoplastic -- adverse effects KW - Anticoagulants -- therapeutic use KW - Deoxycytidine -- analogs & derivatives KW - Anticoagulants -- adverse effects KW - Warfarin -- adverse effects KW - Deoxycytidine -- therapeutic use KW - Warfarin -- therapeutic use KW - Antimetabolites, Antineoplastic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68479632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Capecitabine-warfarin+interaction.&rft.au=Janney%2C+Laurel+M%3BWaterbury%2C+Nancee+V&rft.aulast=Janney&rft.aufirst=Laurel&rft.date=2005-09-01&rft.volume=39&rft.issue=9&rft.spage=1546&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-26 N1 - Date created - 2005-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Constructing the Stroke: Sudden-Onset Narratives of Stroke Survivors AN - 60038109; 200620613 AB - In this article, the authors explore the narrative production of stroke from the perspectives of survivors, that is, the stroke itself, not its implications for the individual poststroke. In the vast amount of literature on both sudden onset & chronic illness, the narrative construction of the onset of the illness, for the most part, has been ignored by social scientists, most notably in qualitative research. This is certainly true of stroke. Drawing on existing literature in both chronic illness & the body, the authors extend this to explore the phenomenological construction of stroke onset. Using data gathered from in-depth interviews with 111 stroke survivors postdischarge, they suggest three narrative mechanisms are used in the construct of the sudden-onset event itself: the use of typifications to construct the body during stroke, stroke as an internal communicative act, & stroke as a physical sensation & the mechanisms used to minimize bodily concerns. References. [Reprinted by permission of Sage Publications Inc., copyright 2005.] JF - Qualitative Health Research AU - Faircloth, Christopher A AU - Boylstein, Craig AU - Rittman, Maude AU - Gubrium, Jaber F AD - Rehabilitation Outcomes Research Center, North Florida/South Georgia Veterans Administration Medical Center Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 928 EP - 941 PB - Sage Publications, Thousand Oaks CA VL - 15 IS - 7 SN - 1049-7323, 1049-7323 KW - stroke KW - chronic illness KW - narrative KW - body KW - Chronic Illness KW - Human Body KW - Patients KW - Narratives KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60038109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Qualitative+Health+Research&rft.atitle=Constructing+the+Stroke%3A+Sudden-Onset+Narratives+of+Stroke+Survivors&rft.au=Faircloth%2C+Christopher+A%3BBoylstein%2C+Craig%3BRittman%2C+Maude%3BGubrium%2C+Jaber+F&rft.aulast=Faircloth&rft.aufirst=Christopher&rft.date=2005-09-01&rft.volume=15&rft.issue=7&rft.spage=928&rft.isbn=&rft.btitle=&rft.title=Qualitative+Health+Research&rft.issn=10497323&rft_id=info:doi/10.1177%2F1049732305277842 LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Number of references - 41 N1 - Last updated - 2016-09-28 N1 - CODEN - QHREEM N1 - SubjectsTermNotLitGenreText - Chronic Illness; Human Body; Narratives; Patients DO - http://dx.doi.org/10.1177/1049732305277842 ER - TY - JOUR T1 - Advancing Appraisal: Aphasia and the WHO AN - 57195642; 200611556 AB - Limitations of current methods used in the appraisal of aphasic individuals are reviewed with emphasis on the potential insufficiency of available measures for the focusing of socially valid treatment & the evaluation of its outcomes; consequently, it is urged that aphasia appraisal be situated in the context of the family of international classifications of functioning, disability, & quality of life developed by the World Health Organization (WHO). Relevant component measures, including the International Classification of Functioning, Disability, & Health (ICF) & the long- & short-form WHOQOL quality-of-life instruments, are described & shown to incorporate information lying beyond the scope of disease-specific measures, eg, the Stroke and Aphasia Quality of Life Scale-39. A suggested programmatic approach involves the development of body-, activity-, & participation-level measures, standard protocols for the appraisal of relevant personal & environmental variables, & disease-specific quality-of-life measures with wide scope. Commentary is provided by Katerina Hilari, Claire Penn, Travis T. Threats, & Linda Worrall & Madeline Cruice. Topics addressed include the need to base assessments on empirical knowledge of the constructs being measured; fundamental differences between the ICF & WHOQOL; the failure of WHO protocols to draw on theoretical bases in anthropology, sociology, linguistics, & pragmatics; & the relevance of existing measures to domains identified by patients as significant. The authors' reply examines questions of programmatic vs so-called eclectic appraisal, overall vs health-related quality of life in the scope of appraisals, standardized vs so-called individualized measures, clinical vs research appraisal, & motivations for the development of new measures. 176 References. J. Hitchcock JF - Aphasiology AU - Ross, Katherine B AU - Wertz, Robert T AD - Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ katherine.ross3@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 860 EP - 900 PB - Taylor & Francis Ltd / Psychology Press, Basingstoke UK VL - 19 IS - 9 SN - 0268-7038, 0268-7038 KW - Diagnosis KW - Aphasia KW - Therapy KW - Language disorders KW - Patients KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57195642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Advancing+Appraisal%3A+Aphasia+and+the+WHO&rft.au=Ross%2C+Katherine+B%3BWertz%2C+Robert+T&rft.aulast=Ross&rft.aufirst=Katherine&rft.date=2005-09-01&rft.volume=19&rft.issue=9&rft.spage=860&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/10.1080%2F02687030544000038 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-07-28 N1 - SuppNotes - Comments, 870-893; Reply, 893-900. N1 - Last updated - 2016-09-27 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - Aphasia; Language disorders; Therapy; Patients; Diagnosis DO - http://dx.doi.org/10.1080/02687030544000038 ER - TY - JOUR T1 - Comorbidity Is a Better Predictor of Impaired Immunity than Chronological Age in Older Adults AN - 57091684; 200600134 AB - OBJECTIVES: To determine whether high level of comorbidity, measured using a standardized instrument, can predict impaired immunity in older adults. SETTING: Geriatric outpatient Clinic and Nursing Home Care Unit of Veterans Affairs Greater Los Angeles Healthcare System. PARTICIPANTS: Fifteen men aged 51 to 95 with varying levels of chronic illness. MEASUREMENTS: Disease burden was measured using the Cumulative Illness Rating Scale (CIRS) and immunity using proliferation of T cells induced by phytohemagglutinin (PHA) and production of interleukin (IL)-12, a proinflammatory cytokine that promotes T helper cell-dependent immune response, and IL-10, a cytokine that inhibits T helper cell-dependent immune response, in response to mitogenic stimulation of peripheral blood mononuclear cells. RESULTS: With increasing comorbidity (increase in CIRS score) in older adults, there is a proportional decrease in immune response (decrease in T cell proliferation and IL-12 production and increase in IL-10 production in response to PHA stimulation). Neither immune response nor CIRS score was significantly correlated with chronological age in this sample of older adults with varying degrees of chronic illness. CONCLUSION: This study demonstrates that the level of comorbidity correlates with the magnitude of immune response in older adults and suggests that the CIRS could be used to determine the magnitude of impaired immunity in older adults with different specific illnesses and different levels of severity. Illustrations, Tables, References. Adapted from the source document. JF - Journal of the American Geriatrics Society AU - Castle, Steven Charles AU - Uyemura, Koichi AU - Rafi, Asif AU - Akande, Omosalewa AU - Makinodan, Takashi AD - VA Greater Los Angeles Healthcare System, CA steven.castle@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 1565 EP - 1569 PB - JAGSAF VL - 53 IS - 9 SN - 0002-8614, 0002-8614 KW - immunosenescence KW - interleukin-10 and -12 KW - comorbidity KW - CIRS KW - immunity KW - aging KW - Ageing KW - Elderly people KW - Immune response KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57091684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Comorbidity+Is+a+Better+Predictor+of+Impaired+Immunity+than+Chronological+Age+in+Older+Adults&rft.au=Castle%2C+Steven+Charles%3BUyemura%2C+Koichi%3BRafi%2C+Asif%3BAkande%2C+Omosalewa%3BMakinodan%2C+Takashi&rft.aulast=Castle&rft.aufirst=Steven&rft.date=2005-09-01&rft.volume=53&rft.issue=9&rft.spage=1565&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2005.53512.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JAGSAF N1 - SubjectsTermNotLitGenreText - Comorbidity; Ageing; Immune response; Elderly people DO - http://dx.doi.org/10.1111/j.1532-5415.2005.53512.x ER - TY - JOUR T1 - Association between Parkinson's Disease and Low Bone Density and Falls in Older Men: The Osteoporotic Fractures in Men Study AN - 57081590; 200600263 AB - OBJECTIVES: To examine the association between Parkinson's disease (PD) and bone mineral density (BMD) and risk of falls. DESIGN: Cross-sectional and prospective cohort study. SETTING: Six U.S. clinical centers. PARTICIPANTS: Five thousand nine hundred ninety-five community-dwelling, ambulatory men aged 65 and older. MEASUREMENTS: History of physician-diagnosed PD was ascertained from participant self-report. BMD was measured at the hip and spine using dual energy x-ray absorptiometry (DEXA) and quantitative computed tomography (QCT). Incident falls were ascertained for 1 year using mailed queries. RESULTS: Fifty-two participants (0.9%) reported a history of PD. In multivariate models, PD was associated with significantly lower BMD at the spine (- 4.9%, P = .04) and total hip (- 5.3%, P = .007) using DEXA and at the spine (-6.7%, P =.05) and total hip (-8.2%, P =.03) using QCT. PD was associated with a nearly three times greater age-adjusted risk of multiple future falls (odds ratio (OR) = 2.91, 95% confidence interval (CI) = 1.55-5.46). Further adjustment for history of multiple falls in the year before baseline attenuated this risk, but it remained significant (OR = 2.30, 95% CI = 1.15-4.59). CONCLUSION: In this cohort of older men, PD was associated with lower BMD at the hip and spine, measured using areal and volumetric BMD, as well as increased falls. Clinicians should consider screening older men with PD for osteoporosis. Tables, References. Adapted from the source document. JF - Journal of the American Geriatrics Society AU - Fink, Howard A AU - Kuskowski, Michael A AU - Orwoll, Eric S AU - Cauley, Jane A AU - Ensrud, Kristine E AD - VA Medical Center, Minneapolis, MN howard.fink@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 1559 EP - 1564 PB - JAGSAF VL - 53 IS - 9 SN - 0002-8614, 0002-8614 KW - Parkinson's disease KW - osteoporosis KW - bone density KW - accidental falls KW - Bone mineral density KW - Falls KW - Osteoporosis KW - Brittle bones KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57081590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Association+between+Parkinson%27s+Disease+and+Low+Bone+Density+and+Falls+in+Older+Men%3A+The+Osteoporotic+Fractures+in+Men+Study&rft.au=Fink%2C+Howard+A%3BKuskowski%2C+Michael+A%3BOrwoll%2C+Eric+S%3BCauley%2C+Jane+A%3BEnsrud%2C+Kristine+E&rft.aulast=Fink&rft.aufirst=Howard&rft.date=2005-09-01&rft.volume=53&rft.issue=9&rft.spage=1559&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2005.53464.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JAGSAF N1 - SubjectsTermNotLitGenreText - Parkinson's disease; Osteoporosis; Falls; Brittle bones; Bone mineral density DO - http://dx.doi.org/10.1111/j.1532-5415.2005.53464.x ER - TY - JOUR T1 - Effect of donors' intravenous drug use, cigarette smoking, and alcohol dependence on kidney transplant outcome. AN - 68517415; 16123722 AB - The shortage of organ donors for kidney transplants has made the expansion of the kidney donor pool a clinically significant issue. Previous studies suggest that kidneys from donors with a history of intravenous (IV) drug, cigarette, and/or alcohol use are considered to be a risky choice. However, these kidneys could potentially be used and expand the kidney supply pool if no evidence shows their association with adverse transplant outcomes. This study analyzed the United Network for Organ Sharing dataset from 1994 to 1999 using Kaplan-Meier survival analysis and Cox modeling. The effects on transplant outcome (graft and recipient survival) were examined with respect to the donors' IV drug use, cigarette smoking, and alcohol dependency. Covariates including the recipient variables, the donor variables, and the transplant procedure variables were included in the Cox models. The results show that the donors' history of cigarette smoking is a statistically significant risk factor for both graft survival (hazard ratio=1.05, P<0.05) and recipient survival (1.06, P<0.05), whereas neither IV drug use nor alcohol dependency had significant adverse impact on graft or recipient survival. Assuming that adequate testing for potential infections is performed, there is no evidence to support avoiding the kidneys from donors with IV drug use or alcohol dependency in transplantation. Utilizing these kidneys would clearly expand the potential pool of donor organs. JF - Transplantation AU - Lin, Shih-jui AU - Koford, James K AU - Baird, Bradley C AU - Hurdle, John F AU - Krikov, Sergey AU - Habib, Arsalan N AU - Goldfarb-Rumyantzev, Alexander S AD - Department Of Medical Informatics, University of Utah Health Sciences Center, and the Geriatric Research, Education, and Clinical Center, Veterans Administration Salt Lake City Healthcare System, Salt Lake City, UT 84112, USA. Y1 - 2005/08/27/ PY - 2005 DA - 2005 Aug 27 SP - 482 EP - 486 VL - 80 IS - 4 SN - 0041-1337, 0041-1337 KW - Index Medicus KW - Humans KW - Retrospective Studies KW - Waiting Lists KW - Survival Rate KW - Risk Factors KW - Incidence KW - Follow-Up Studies KW - Middle Aged KW - Time Factors KW - United States -- epidemiology KW - Female KW - Male KW - Proportional Hazards Models KW - Kidney Transplantation -- statistics & numerical data KW - Kidney Transplantation -- mortality KW - Graft Survival KW - Graft Rejection -- etiology KW - Smoking -- adverse effects KW - Substance Abuse, Intravenous -- complications KW - Graft Rejection -- epidemiology KW - Alcoholism -- complications KW - Tissue Donors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68517415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation&rft.atitle=Effect+of+donors%27+intravenous+drug+use%2C+cigarette+smoking%2C+and+alcohol+dependence+on+kidney+transplant+outcome.&rft.au=Lin%2C+Shih-jui%3BKoford%2C+James+K%3BBaird%2C+Bradley+C%3BHurdle%2C+John+F%3BKrikov%2C+Sergey%3BHabib%2C+Arsalan+N%3BGoldfarb-Rumyantzev%2C+Alexander+S&rft.aulast=Lin&rft.aufirst=Shih-jui&rft.date=2005-08-27&rft.volume=80&rft.issue=4&rft.spage=482&rft.isbn=&rft.btitle=&rft.title=Transplantation&rft.issn=00411337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-15 N1 - Date created - 2005-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanical ventilation exacerbates alveolar macrophage dysfunction in the lungs of ethanol-fed rats. AN - 68532274; 16131854 AB - Patients with alcohol abuse have a two- to three-fold increased risk of acute lung injury and respiratory failure after sepsis or trauma but are also at increased risk of nosocomial pneumonia. Mechanical ventilation exacerbates lung injury during critical illnesses. In this study we tested whether mechanical ventilation of the alcoholic lung promotes on balance a proinflammatory phenotype favoring ventilator-induced lung injury or an immunosuppressive phenotype favoring ventilator-associated pneumonia. Lungs from rats fed an isocaloric diet with or without ethanol (six weeks) were isolated and ventilated ex vivo with a low-volume (protective) or high-volume (injurious) strategy for two hours with or without prior endotoxemia (two hours). In other experiments, rats were subjected to high-volume ventilation in vivo. Airway levels of the proinflammatory cytokines tumor necrosis factor-alpha, macrophage inflammatory protein-2, and interleukin-1beta were determined after mechanical ventilation ex vivo and compared with edematous lung injury after high-volume ventilation in vivo. In parallel, alveolar macrophage phagocytosis of bacteria and secretion of interleukin-12 during ventilation ex vivo and endotoxin-stimulated alveolar macrophage phagocytosis and tumor necrosis factor-alpha secretion in vitro were determined. Ethanol ingestion suppressed the proinflammatory response to injurious mechanical ventilation and did not increase experimental ventilator-induced lung injury. In parallel, ethanol ingestion blunted the innate immune response of alveolar macrophages during injurious ventilation ex vivo and after endotoxin stimulation in vitro. Ethanol ingestion dampens ventilator-induced inflammation but exacerbates macrophage immune dysfunction. These findings could explain at least in part why alcoholic patients are at increased risk of ventilator-associated pneumonia. JF - Alcoholism, clinical and experimental research AU - Kamat, Pradip P AU - Slutsky, Arthur AU - Zhang, Haibo AU - Bechara, Rabih I AU - Brown, Lou Ann S AU - Garcia, Raena C AU - Joshi, Pratibha C AU - Kershaw, Corey D AU - Guidot, David M AD - Atlanta Veterans Administration Medical Center and the Department of Pediatrics, Emory University, Atlanta, Georgia, USA. Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 1457 EP - 1465 VL - 29 IS - 8 SN - 0145-6008, 0145-6008 KW - Inflammation Mediators KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Endotoxemia -- immunology KW - Animals KW - Rats, Sprague-Dawley KW - Inflammation Mediators -- blood KW - Opportunistic Infections -- immunology KW - Lung Injury KW - Tidal Volume -- physiology KW - Salmonella typhimurium -- immunology KW - Male KW - Lung -- immunology KW - Ethanol -- toxicity KW - Positive-Pressure Respiration KW - Alcoholism -- immunology KW - Macrophages, Alveolar -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68532274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Mechanical+ventilation+exacerbates+alveolar+macrophage+dysfunction+in+the+lungs+of+ethanol-fed+rats.&rft.au=Kamat%2C+Pradip+P%3BSlutsky%2C+Arthur%3BZhang%2C+Haibo%3BBechara%2C+Rabih+I%3BBrown%2C+Lou+Ann+S%3BGarcia%2C+Raena+C%3BJoshi%2C+Pratibha+C%3BKershaw%2C+Corey+D%3BGuidot%2C+David+M&rft.aulast=Kamat&rft.aufirst=Pradip&rft.date=2005-08-01&rft.volume=29&rft.issue=8&rft.spage=1457&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-term use of benzodiazepines in participants with comorbid anxiety and alcohol use disorders. AN - 68530917; 16131848 AB - Although the only widely accepted role for benzodiazepines in alcohol dependence is the treatment of withdrawal syndromes, they are frequently prescribed outside of this clinical setting. There is little empirical evidence to guide the rational use of benzodiazepines in the common clinical situation where anxiety disorders are comorbid with alcohol use disorders (AUD). Since January 1989, the Harvard Anxiety Research Program has naturalistically monitored the prospective clinical course of people with anxiety disorders, some of whom had a history of AUD. Earlier research showed that the use of benzodiazepines was not significantly associated with the presence or absence of a history of an AUD over the first year of follow-up. This report extends that investigation. Using standard parametric analytic methods, patterns of benzodiazepine use (routinely prescribed medication and as-needed [PRN] use) among participants receiving benzodiazepine treatment was prospectively examined over the course of 12 years. Differences in benzodiazepine usage patterns were examined in each year of follow-up between participants who did (n=120) and did not (n=425) have a new episode of AUD. Using proportional hazards regression analysis, benzodiazepine usage levels were examined as predictors of recovery and recurrence of AUD. Additionally, random-effects regression analyses were used to examine the patterns of benzodiazepine use before and after the onset of a prospectively observed episode of AUD. Benzodiazepine usage levels remained stable for the full sample over the course of the 12 years. Benzodiazepine use did not distinguish participants who had a new AUD from those who did not. Over the 12 years of follow-up, participants who had an AUD used more PRN medication in years five to eight. This difference reached statistical significance but was not clinically significant. Benzodiazepine usage levels did not predict recovery or recurrence in AUD subjects. Neither the total dose nor the PRN usage of benzodiazepines was significantly associated with the onset of AUD, but when combined into a measure of any benzodiazepine use, a relationship between increased use and the onset of AUD emerged. For participants in the Harvard Anxiety Research Program with comorbid alcohol dependence and anxiety disorders, there was little association between the use of benzodiazepines and the occurrence of a new AUD. Neither was there a temporal relationship between the use of benzodiazepines and the onset of a new AUD. Whether or not this finding extends to a broader patient population or a group of people who present to addictions treatment awaits further investigation. JF - Alcoholism, clinical and experimental research AU - Mueller, Timothy I AU - Pagano, Maria E AU - Rodriguez, Benjamin F AU - Bruce, Steven E AU - Stout, Robert L AU - Keller, Martin B AD - Southern Arizona VA Health Care System, University of Arizona Health Sciences Center, Department of Psychiatry, Tucson, Arizona 85723, USA. timothy.mueller@med.va.gov Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 1411 EP - 1418 VL - 29 IS - 8 SN - 0145-6008, 0145-6008 KW - Benzodiazepines KW - 12794-10-4 KW - Index Medicus KW - Prospective Studies KW - Substance Withdrawal Syndrome -- rehabilitation KW - Humans KW - Adult KW - Middle Aged KW - Long-Term Care KW - Follow-Up Studies KW - Longitudinal Studies KW - Recurrence KW - Male KW - Female KW - Comorbidity KW - Alcoholism -- rehabilitation KW - Benzodiazepines -- adverse effects KW - Alcoholism -- epidemiology KW - Benzodiazepines -- administration & dosage KW - Anxiety Disorders -- rehabilitation KW - Anxiety Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68530917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Long-term+use+of+benzodiazepines+in+participants+with+comorbid+anxiety+and+alcohol+use+disorders.&rft.au=Mueller%2C+Timothy+I%3BPagano%2C+Maria+E%3BRodriguez%2C+Benjamin+F%3BBruce%2C+Steven+E%3BStout%2C+Robert+L%3BKeller%2C+Martin+B&rft.aulast=Mueller&rft.aufirst=Timothy&rft.date=2005-08-01&rft.volume=29&rft.issue=8&rft.spage=1411&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-08-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Subst Abuse. 1992;4(1):19-26 [1320971] J Nerv Ment Dis. 1994 May;182(5):290-6 [10678311] Am J Addict. 2000 Fall;9(4):276-9; discussion 280-4 [11155783] Alcohol Alcohol. 1998 Nov-Dec;33(6):563-75 [9872344] Br J Psychiatry Suppl. 1998;(34):24-8 [9829013] Compr Psychiatry. 1998 Jul-Aug;39(4):176-84 [9675501] Arch Gen Psychiatry. 1997 Apr;54(4):313-21 [9107147] J Fam Pract. 1996 Apr;42(4):342 [8627189] J Clin Psychiatry. 1996 Feb;57(2):83-9 [8591974] J Psychiatr Res. 1994 Nov-Dec;28(6):531-45 [7699612] Am J Psychiatry. 1994 Dec;151(12):1723-34 [7977877] Arch Gen Psychiatry. 1994 Sep;51(9):720-31 [8080349] Am J Psychiatry. 1993 Apr;150(4):600-7 [8465877] Alcohol Clin Exp Res. 1992 Dec;16(6):1007-13 [1335217] J Subst Abuse. 1992;4(2):179-85 [1354514] Psychiatr Serv. 1999 Oct;50(10):1359-61 [10506309] Am J Psychiatry. 2005 Jun;162(6):1179-87 [15930067] Arch Gen Psychiatry. 1990 Oct;47(10):899-907 [2222129] Am J Psychiatry. 1990 Jun;147(6):685-95 [2188513] Am J Psychiatry. 1989 May;146(5):683-4 [2565691] Am J Psychiatry. 1988 Dec;145(12):1501-6 [2904227] Arch Gen Psychiatry. 1987 Jun;44(6):540-8 [3579500] Arch Gen Psychiatry. 1985 Nov;42(11):1050-5 [4051682] Am J Psychiatry. 2003 Aug;160(8):1432-8 [12900305] Depress Anxiety. 2003;17(3):173-9 [12768651] J Clin Psychiatry. 2002 Sep;63(9):756-7 [12363113] Am J Addict. 2001 Winter;10(1):48-68 [11268828] Arch Gen Psychiatry. 1990 Oct;47(10):908-15 [2222130] JAMA. 1990 Nov 21;264(19):2511-8 [2232018] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Season, sun, sex, and cervical cancer. AN - 68480606; 16103441 AB - Sunlight's UV B component, a known cellular immunosupressant, carcinogen, and activator of viral infections, is generally seasonally available. Venereal human papillomavirus (HPV) transmission, at least in part, causes cervical cancer. We have previously inspected the monthly rates of venereal HPV infection and sunlight fluency in Southern Holland over 16 consecutive years. Both peak in August with at least 2-fold seasonality. The amount of available sunlight and the rate of Papanicolaou (Pap) smear screen-detected HPV are positively correlated. We now investigate whether premalignant and malignant cervical epithelial changes are also seasonal and related to seasonal sunlight fluency. We have studied >900,000 consecutive, serially independent, interpretable screening Pap smears obtained by a single cervical cancer screening laboratory in Leiden, Holland, during a continuous 16-year span from 1983 through 1998. The average monthly rates of premalignant and malignant epithelial change were inspected and the annual patterns contrasted to the annual pattern of sunlight fluency at this global location and to monthly average HPV infection rate. Because HPV is venereally transmitted, Dutch seasonal sexual behavior was evaluated by assessment of the annual pattern of Dutch conception frequency as a competing cause for cervical cancer seasonality. (a) Twice as many premalignant and malignant epithelial changes were found among Pap smears obtained in the summer months, with an August peak concurrent with histopathologic evidence of HPV infection and sunlight fluency in Southern Holland. (b) Monthly sunlight fluency is correlated positively with both the monthly rates of Pap smear-detected cervical epithelial dysplasia and carcinomatous histopathology, as well as HPV. (c) Conception frequency, in this location, peaks in Spring not summer, and has a 4.8% annual amplitude. (a) Cervical epithelial HPV infection and HPV-induced cervical epithelial dysplasia and carcinomatous change may each be novel sun exposure risks and thereby behaviorably avoidable. (b) Because screening Pap smears uncover many abnormalities that resolve spontaneously (false positives), these data may argue for screening and follow-up Pap smear examinations in seasons other than summer in the Northern Hemisphere, to diminish the false-positive smear rate. Global data are available to confirm and further test each of these conclusions. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Hrushesky, William J M AU - Sothern, Robert B AU - Rietveld, Wop J AU - Du Quiton, Jovelyn AU - Boon, Mathilde E AD - Department of Epidemiology and Biostatistics, Norman J. Arnold of Public Health, University of South Carolina, Columbia, SC 29209, USA. william.hrushesky@med.va.gov Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 1940 EP - 1947 VL - 14 IS - 8 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Netherlands -- epidemiology KW - Mass Screening KW - Analysis of Variance KW - Humans KW - Adult KW - Vaginal Smears KW - Incidence KW - Female KW - Sex KW - Papanicolaou Test KW - Uterine Cervical Neoplasms -- etiology KW - Uterine Cervical Dysplasia -- pathology KW - Uterine Cervical Neoplasms -- classification KW - Papillomavirus Infections -- epidemiology KW - Uterine Cervical Dysplasia -- etiology KW - Papillomavirus Infections -- complications KW - Papillomaviridae -- isolation & purification KW - Seasons KW - Solar System KW - Uterine Cervical Dysplasia -- virology KW - Uterine Cervical Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68480606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Season%2C+sun%2C+sex%2C+and+cervical+cancer.&rft.au=Hrushesky%2C+William+J+M%3BSothern%2C+Robert+B%3BRietveld%2C+Wop+J%3BDu+Quiton%2C+Jovelyn%3BBoon%2C+Mathilde+E&rft.aulast=Hrushesky&rft.aufirst=William+J&rft.date=2005-08-01&rft.volume=14&rft.issue=8&rft.spage=1940&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-08 N1 - Date created - 2005-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Commentary: Adding to our comprehension of Gulf War health questions. AN - 68444992; 15972305 JF - International journal of epidemiology AU - Hyams, Kenneth Craig AD - Occupational and Environmental Strategic Healthcare Group, Office of Public Health and Environmental Hazards, Department of Veterans Affairs, VA Central Office (13A), 810 Vermont Avenue NW, Washington, DC 20420, USA. kenneth.hyams@va.gov Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 808 EP - 809 VL - 34 IS - 4 SN - 0300-5771, 0300-5771 KW - Index Medicus KW - Veterans KW - Saudi Arabia -- epidemiology KW - Humans KW - Occupational Exposure -- adverse effects KW - United States -- epidemiology KW - Gulf War KW - Military Personnel KW - Occupational Diseases -- epidemiology KW - Persian Gulf Syndrome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68444992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+epidemiology&rft.atitle=Commentary%3A+Adding+to+our+comprehension+of+Gulf+War+health+questions.&rft.au=Hyams%2C+Kenneth+Craig&rft.aulast=Hyams&rft.aufirst=Kenneth&rft.date=2005-08-01&rft.volume=34&rft.issue=4&rft.spage=808&rft.isbn=&rft.btitle=&rft.title=International+journal+of+epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-07 N1 - Date created - 2005-08-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Int J Epidemiol. 2005 Aug;34(4):801-8 [15737976] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mortality in US Army Gulf War veterans exposed to 1991 Khamisiyah chemical munitions destruction. AN - 68075873; 16043669 AB - We investigated whether US Army Gulf War veterans who were potentially exposed to nerve agents during the March 1991 weapons demolitions at Khamisiyah, Iraq, are at increased risk of cause-specific mortality. The cause-specific mortality of 100487 exposed US Army Gulf War veterans was compared with that of 224980 unexposed US Army Gulf War veterans. Exposure was determined with the Department of Defense 2000 plume model. Relative risk estimates were derived from Cox proportional hazards models. The risks of most disease-related mortality were similar for exposed and unexposed veterans. However, exposed veterans had an increased risk of brain cancer deaths (relative risk [RR]=1.94; 95% confidence interval [CI]=1.12, 3.34). The risk of brain cancer death was larger among those exposed 2 or more days than those exposed 1 day when both were compared separately to all unexposed veterans (RR=3.26; 95% CI=1.33, 7.96; RR=1.72; 95% CI=0.95,3.10, respectively). Exposure to chemical munitions at Khamisiyah may be associated with an increased risk of brain cancer death. Additional research is required to confirm this finding. JF - American journal of public health AU - Bullman, Tim A AU - Mahan, Clare M AU - Kang, Han K AU - Page, William F AD - Department of Veterans Affairs, Veterans Health Administration, Mail Stop 135, Environmental Epidemiology Service, 810 Vermont Ave, Washington, DC 20420, USA. tim.bullman@hq.med.va.gov Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 1382 EP - 1388 VL - 95 IS - 8 SN - 0090-0036, 0090-0036 KW - Chemical Warfare Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Risk KW - Humans KW - Adult KW - United States -- epidemiology KW - Male KW - Iraq KW - Female KW - Risk Assessment KW - Proportional Hazards Models KW - Veterans -- statistics & numerical data KW - Gulf War KW - Brain Neoplasms -- mortality KW - Chemical Warfare Agents -- adverse effects KW - Military Personnel -- statistics & numerical data KW - Cause of Death KW - Military Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68075873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Mortality+in+US+Army+Gulf+War+veterans+exposed+to+1991+Khamisiyah+chemical+munitions+destruction.&rft.au=Bullman%2C+Tim+A%3BMahan%2C+Clare+M%3BKang%2C+Han+K%3BPage%2C+William+F&rft.aulast=Bullman&rft.aufirst=Tim&rft.date=2005-08-01&rft.volume=95&rft.issue=8&rft.spage=1382&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-20 N1 - Date created - 2005-07-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 2001 Sep 1;154(5):399-405 [11532780] Lancet. 2000 Jul 1;356(9223):17-21 [10892759] Toxicol Appl Pharmacol. 2002 Oct 15;184(2):82-7 [12408952] Arch Environ Health. 2002 Jul-Aug;57(4):270-2 [12530592] Toxicol Ind Health. 2001 Jun;17(5-10):294-7 [12539875] Am J Epidemiol. 1980 Jan;111(1):99-112 [7352463] Am J Public Health. 1981 Mar;71(3):242-50 [7468855] J Natl Cancer Inst. 1983 Jan;70(1):75-81 [6571925] N Engl J Med. 1987 Apr 23;316(17):1044-50 [3561457] J Natl Cancer Inst. 1987 Aug;79(2):233-8 [3474455] Am J Epidemiol. 1988 Oct;128(4):778-85 [3421243] Am J Epidemiol. 1995 Jan 15;141(2):123-34 [7817968] Neurol Clin. 1996 May;14(2):273-90 [8827171] N Engl J Med. 1996 Nov 14;335(20):1498-504 [8890102] Am J Epidemiol. 1999 Sep 1;150(5):532-40 [10472954] Am J Epidemiol. 2002 May 15;155(10):908-17 [11994230] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identifying a negative mood subtype in incarcerated adolescents: relationship to substance use. AN - 68041783; 16022939 AB - The following study tested the empirical validity and clinical meaningfulness of a negative mood subtype of incarcerated adolescent males (N=270). Differences in alcohol and marijuana use and consequences were examined. Participants were subtyped according to reports of depressive and anxious symptoms using the Children's Depression Inventory and the Revised Children's Manifest Anxiety Scale. Cluster analysis confirmed the presence of negative mood (34%) and normal mood (66%) subtypes. Incarcerated adolescents in the negative mood subtype reported higher levels of alcohol use, higher levels of use-related consequences for both alcohol and marijuana, greater use of both substances to regulate mood states, and more use of avoidant coping. Results underscore the need for identification and treatment of mental health and substance use difficulties in the juvenile justice system. JF - Addictive behaviors AU - Turner, Aaron P AU - Larimer, Mary E AU - Sarason, Irwin G AU - Trupin, Eric W AD - VA Puget Sound Health Care System, and Department of Rehabilitation Medicine, University of Washington, Seattle 98108, United States. Aaron.Turner@med.va.gov Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 1442 EP - 1448 VL - 30 IS - 7 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Adolescent Behavior KW - Marijuana Smoking -- psychology KW - Adaptation, Psychological KW - Humans KW - Alcohol Drinking -- psychology KW - Diagnosis, Dual (Psychiatry) -- psychology KW - Adolescent KW - Psychometrics KW - Cluster Analysis KW - Male KW - Anxiety -- psychology KW - Depression -- psychology KW - Substance-Related Disorders -- psychology KW - Prisoners -- psychology KW - Juvenile Delinquency -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68041783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Identifying+a+negative+mood+subtype+in+incarcerated+adolescents%3A+relationship+to+substance+use.&rft.au=Turner%2C+Aaron+P%3BLarimer%2C+Mary+E%3BSarason%2C+Irwin+G%3BTrupin%2C+Eric+W&rft.aulast=Turner&rft.aufirst=Aaron&rft.date=2005-08-01&rft.volume=30&rft.issue=7&rft.spage=1442&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-22 N1 - Date created - 2005-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Telephone self-monitoring among alcohol use disorder patients in early recovery: a randomized study of feasibility and measurement reactivity. AN - 68014314; 16002033 AB - Frequent symptom self-monitoring protocols have become popular tools in the addiction field. Interactive Voice Response (IVR) is a telephone monitoring system that has been shown to be feasible for collecting frequent self-reports from a variety of research populations. Little is known, however, about the feasibility of using IVR monitoring in clinical samples, and few controlled trials exist assessing the impact of any type of frequent self-report monitoring on the behaviors monitored. This pilot study with patients in early recovery from an alcohol use disorder (n=98) evaluated compliance with two IVR monitoring protocols, subjective experiences with monitoring, and change in symptoms associated with monitoring (i.e., measurement reactivity). Participants were randomly assigned to call an IVR system daily for 28 days, once per week for 4 weeks, or only to complete 28-day follow-up assessment including retrospective drinking reports. Monitoring calls assessed alcohol craving, substance use, emotional well-being, and PTSD symptoms. Most monitoring participants completed calls on at least 75% of scheduled days (72.2% and 59.2% for daily and weekly, respectively). Including reconstructed data from follow-up of missed calls yielded 77.8% and 74.1% of maximum data points, respectively. Most monitoring participants indicated the protocol was manageable and reported positive or no effects of monitoring on urges to use alcohol, actual drinking, and PTSD symptoms. Analyses of measurement reactivity based on assessment one month after randomization found no significant group differences on drinking, craving for alcohol, or PTSD-related symptoms. Results suggest that IVR technology is feasible and appropriate for telephone symptom monitoring in similar clinical samples. JF - Drug and alcohol dependence AU - Simpson, Tracy L AU - Kivlahan, Daniel R AU - Bush, Kristen R AU - McFall, Miles E AD - VISN 20 Mental Illness Research Education and Clinical Center, Seattle, WA 98108, USA. tracy.simpson@med.va.gov Y1 - 2005/08/01/ PY - 2005 DA - 2005 Aug 01 SP - 241 EP - 250 VL - 79 IS - 2 SN - 0376-8716, 0376-8716 KW - Index Medicus KW - Feasibility Studies KW - Analysis of Variance KW - Washington KW - Self Care KW - Patient Compliance KW - Voice KW - Humans KW - Pilot Projects KW - Middle Aged KW - Temperance KW - Male KW - Female KW - Hospitals, Veterans KW - Self Disclosure KW - Telephone KW - Substance Abuse Treatment Centers KW - Alcohol-Related Disorders -- therapy KW - Alcohol-Related Disorders -- psychology KW - Aftercare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68014314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Telephone+self-monitoring+among+alcohol+use+disorder+patients+in+early+recovery%3A+a+randomized+study+of+feasibility+and+measurement+reactivity.&rft.au=Simpson%2C+Tracy+L%3BKivlahan%2C+Daniel+R%3BBush%2C+Kristen+R%3BMcFall%2C+Miles+E&rft.aulast=Simpson&rft.aufirst=Tracy&rft.date=2005-08-01&rft.volume=79&rft.issue=2&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-09 N1 - Date created - 2005-07-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Counseling Utilization by Ethnic Minority College Students AN - 61395075; 200601535 AB - Although multicultural awareness in counseling has risen substantially in the last decade, little research has examined counseling utilization & outcomes for ethnic minorities on university campuses. A sample of 1,166 African American, Asian American, Caucasian, & Latino help-seeking university students from over 40 universities nationwide filled out the Outcome Questionnaire 45 (OQ45) at the first & last therapy sessions. Caucasian students attended significantly more sessions than all other groups. Greatest distress was found at intake in Asian American students, followed by Latino, African American, & Caucasian students. All groups appeared to benefit from therapy, as noted by a decrease in symptomatology, but none of the groups met the criteria for clinically significant change for the OQ45. Implications for therapists working with minority clients are discussed. Tables, References. Adapted from the source document. JF - Cultural Diversity & Ethnic Minority Psychology AU - Kearney, Lisa K AD - South Texas Veterans Health Care System, San Antonio, TX lisa.kearney3@med.va.gov Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 272 EP - 285 VL - 11 IS - 3 SN - 1099-9809, 1099-9809 KW - university students, psychotherapy, treatment research, ethnic minorities KW - Minority Groups KW - Services KW - Psychotherapy KW - Ethnicity KW - College Students KW - Utilization KW - article KW - 6148: problems of minority groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61395075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cultural+Diversity+%26+Ethnic+Minority+Psychology&rft.atitle=Counseling+Utilization+by+Ethnic+Minority+College+Students&rft.au=Kearney%2C+Lisa+K&rft.aulast=Kearney&rft.aufirst=Lisa&rft.date=2005-08-01&rft.volume=11&rft.issue=3&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Cultural+Diversity+%26+Ethnic+Minority+Psychology&rft.issn=10999809&rft_id=info:doi/10.1037%2F1099-9809.11.3.272 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Ethnicity; College Students; Psychotherapy; Minority Groups; Utilization; Services DO - http://dx.doi.org/10.1037/1099-9809.11.3.272 ER - TY - JOUR T1 - TRANSFUSION COMPLICATIONS: Hemolysis during percutaneous mechanical thrombectomy can mimic a hemolytic transfusion reaction AN - 21342879; 6597119 AB - BACKGROUND:Interventional radiologists have developed percutaneous mechanical thrombectomy (PMT) devices to remove intravascular thrombi. Hemolysis, secondary to thrombus destruction from these devices, has been described in radiology journals, but similar reports appear to be lacking in the transfusion medicine literature. Two cases of hemolysis after PMT are described that involved the transfusion service, one of which was reported as a hemolytic transfusion reaction. CASE REPORTS:The first patient received 4 units of red cells (RBCs) during a thrombectomy and subsequent placement of a transjugular intrahepatic portosystemic shunt. The patient developed hemoglobinuria, and it was reported to the blood bank as a possible hemolytic transfusion reaction. After RBC mismatch and bacterial contamination were excluded, the hemolysis was attributed to thrombectomy-related mechanical hemolysis. In the second case, a hemolyzed sample was sent to the blood bank for a type and cross-match. Upon requesting that the sample be redrawn, it was learned that the sample was obtained after PMT. CONCLUSION:Patients who have undergone PMT can have clinical and laboratory findings suggestive of hemolytic transfusion reactions. Although interventional radiologists are familiar with these side effects, the blood bank profession needs to be aware that these procedures cause nonimmune hemolysis and must consider this possibility when evaluating transfusion reactions in these patients. JF - Transfusion AU - Mair, D C AU - Eastlund, T AU - Rosen, G AU - Covin, R AU - Harmon, J V AU - Menser, M AU - Carr, R AU - Shrwany, S AD - Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, the Department of Radiology, the Department of Surgery, and Department of Anesthesiology, University of Minnesota Medical School, Minneapolis, Minnesota; and the Department of Transfusion Medicine, Veterans Administration Hospital, Minneapolis, Minnesota, maird@usa.redcross.org Y1 - 2005/08// PY - 2005 DA - Aug 2005 SP - 1291 EP - 1294 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 45 IS - 8 SN - 0041-1132, 0041-1132 KW - Microbiology Abstracts B: Bacteriology KW - Cross-match KW - Blood KW - Contamination KW - Shunts KW - Hemolysis KW - Transfusion KW - Radiology KW - Side effects KW - Thrombosis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21342879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=TRANSFUSION+COMPLICATIONS%3A+Hemolysis+during+percutaneous+mechanical+thrombectomy+can+mimic+a+hemolytic+transfusion+reaction&rft.au=Mair%2C+D+C%3BEastlund%2C+T%3BRosen%2C+G%3BCovin%2C+R%3BHarmon%2C+J+V%3BMenser%2C+M%3BCarr%2C+R%3BShrwany%2C+S&rft.aulast=Mair&rft.aufirst=D&rft.date=2005-08-01&rft.volume=45&rft.issue=8&rft.spage=1291&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2005.00208.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - SuppNotes - References, 21. N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Cross-match; Blood; Contamination; Shunts; Hemolysis; Radiology; Transfusion; Thrombosis; Side effects DO - http://dx.doi.org/10.1111/j.1537-2995.2005.00208.x ER - TY - JOUR T1 - E. coli virulence factor hemolysin induces neutrophil apoptosis and necrosis/lysis in vitro and necrosis/lysis and lung injury in a rat pneumonia model AN - 19776823; 6278038 AB - Enteric gram-negative bacilli, such as Escherichia coli are the most common cause of nosocomial pneumonia. In this study a wild-type extraintestinal pathogenic strain of E. coli (ExPEC)(CP9) and isogenic derivatives deficient in hemolysin (Hly) and cytotoxic necrotizing factor (CNF) were assessed in vitro and in a rat model of gram-negative pneumonia to test the hypothesis that these virulence factors induce neutrophil apoptosis and/or necrosis/lysis. As ascertained by in vitro caspase-3/7 and LDH activities and neutrophil morphology, Hly mediated neutrophil apoptosis at lower E. coli titers (1 x 10 super(5-6) cfu) and necrosis/lysis at higher titers ( greater than or equal to 1 x 10 super(7) cfu). Data suggest that CNF promotes apoptosis but not necrosis or lysis. We also demonstrate that annexin V/7-amino-actinomycin D staining was an unreliable assessment of apoptosis using live E. coli. The use of caspase-3/7 and LDH activities and neutrophil morphology supported the notion that necrosis, not apoptosis, was the primary mechanism by which neutrophils were affected in our in vivo gram-negative pneumonia model using live E. coli. In addition, in vivo studies demonstrated that Hly mediates lung injury. Neutrophil necrosis was not observed when animals were challenged with purified lipopolysaccharide, demonstrating the importance of using live bacteria. These findings establish that Hly contributes to ExPEC virulence by mediating neutrophil toxicity, with necrosis/lysis being the dominant effect of Hly on neutrophils in vivo and by lung injury. Whether Hly-mediated lung injury is due to neutrophil necrosis, a direct effect of Hly, or both is unclear. JF - American Journal of Physiology: Lung Cellular and Molecular Physiology AU - Russo, Thomas A AU - Davidson, Bruce A AU - Genagon, Stacy A AU - Warholic, Natalie M AU - MacDonald, Ulrike AU - Pawlicki, Patrick D AU - Beanan, Janet M AU - Olson, Ruth AU - Holm, Bruce A AU - Knight, Paul R, III AD - Departments of Medicine and Microbiology, The Witebsky Center for Microbial Pathogenesis, Veterans Administration Western New York Healthcare System, Departments of Anesthesiology, Pathology, and Pediatrics, Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, Buffalo, New York Y1 - 2005/08// PY - 2005 DA - Aug 2005 SP - L207 EP - L216 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA, [mailto:webmaster@the-aps.org], [URL:http://www.the-aps.org/] VL - 289 IS - 2 SN - 1040-0605, 1040-0605 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Apoptosis KW - Data processing KW - virulence factors KW - Injuries KW - Leukocytes (neutrophilic) KW - Toxicity KW - Necrosis KW - Lung KW - Gram-negative bacilli KW - Colony-forming cells KW - Cytotoxic necrotizing factor KW - Escherichia coli KW - Caspase-3 KW - Lipopolysaccharides KW - Hemolysins KW - Annexin V KW - Pneumonia KW - J 02410:Animal Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19776823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.atitle=E.+coli+virulence+factor+hemolysin+induces+neutrophil+apoptosis+and+necrosis%2Flysis+in+vitro+and+necrosis%2Flysis+and+lung+injury+in+a+rat+pneumonia+model&rft.au=Russo%2C+Thomas+A%3BDavidson%2C+Bruce+A%3BGenagon%2C+Stacy+A%3BWarholic%2C+Natalie+M%3BMacDonald%2C+Ulrike%3BPawlicki%2C+Patrick+D%3BBeanan%2C+Janet+M%3BOlson%2C+Ruth%3BHolm%2C+Bruce+A%3BKnight%2C+Paul+R%2C+III&rft.aulast=Russo&rft.aufirst=Thomas&rft.date=2005-08-01&rft.volume=289&rft.issue=2&rft.spage=L207&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.issn=10400605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Apoptosis; Injuries; virulence factors; Leukocytes (neutrophilic); Toxicity; Necrosis; Gram-negative bacilli; Lung; Cytotoxic necrotizing factor; Colony-forming cells; Caspase-3; Lipopolysaccharides; Hemolysins; Pneumonia; Annexin V; Escherichia coli ER - TY - JOUR T1 - A trial of education, prompts, and opinion leaders to improve prescription of lipid modifying therapy by primary care physicians for patients with ischemic heart disease AN - 19553699; 8747538 AB - Background: Recent clinical trials indicate that treatment with lipid modifying therapy improves outcomes in patients with ischemic heart disease (IHD) and low levels of high density lipoprotein (HDL) cholesterol. The results of these trials, however, have not been widely implemented in clinical practice. Objectives: To develop and test an intervention designed to increase the rate of prescription of lipid modifying therapy and to determine the relative effectiveness of three different prompts (progress notes, patient letters, or computer chart reminders). Methods: The study was conducted in 11 US Department of Veterans Affairs Medical Centers. The effect of the intervention on the proportion of eligible patients receiving lipid modifying therapy was compared between five intervention sites and six matched control sites using a controlled before and after study design. Additionally, 92 providers within the intervention clinics were randomized to receive one of the three prompts. Data were analyzed using logistic regression modeling which incorporated terms to account for the clustered nature of the data. Results: At the intervention sites the prescription rate increased from 8.3% during the pre-intervention period to 39.1% during the intervention (OR = 6.5, 95% CI 5.2 to 8.2, p<0.0001) but remained unchanged at the control sites. The interaction between group (control v intervention) and time period was highly significant (p<0.0001). The adjusted odds of receiving a prescription during the intervention period was 3.1 times higher at the intervention sites than at the control sites (95% CI 2.1 to 4.7). Overall, there was no significant difference in prescription rates among the three prompt groups. However, there was a significant interaction between prompt group and site, indicating that the efficacy of the prompts differed by site. Conclusion: An intervention for primary care providers consisting of an educational workshop, opinion leader influence, and prompts substantially increased the prescription rate of lipid modifying therapy. JF - Quality & Safety in Health Care AU - Bloomfield, HE AU - Nelson, D B AU - van Ryn, M AU - Neil, B J AU - Koets, N J AU - Basile, J N AU - Samaha, F F AU - Kaul, R AU - Mehta, J L AU - Bouland, D AD - Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, Minnesota, USA, hanna.bloomfield@med.va.gov Y1 - 2005/08// PY - 2005 DA - Aug 2005 VL - 14 IS - 4 SN - 1475-3898, 1475-3898 KW - Health & Safety Science Abstracts KW - Lipids KW - clinical trials KW - cholesterol KW - heart diseases KW - opinion leaders KW - Education KW - safety engineering KW - Health care KW - intervention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19553699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quality+%26+Safety+in+Health+Care&rft.atitle=A+trial+of+education%2C+prompts%2C+and+opinion+leaders+to+improve+prescription+of+lipid+modifying+therapy+by+primary+care+physicians+for+patients+with+ischemic+heart+disease&rft.au=Bloomfield%2C+HE%3BNelson%2C+D+B%3Bvan+Ryn%2C+M%3BNeil%2C+B+J%3BKoets%2C+N+J%3BBasile%2C+J+N%3BSamaha%2C+F+F%3BKaul%2C+R%3BMehta%2C+J+L%3BBouland%2C+D&rft.aulast=Bloomfield&rft.aufirst=HE&rft.date=2005-08-01&rft.volume=14&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Quality+%26+Safety+in+Health+Care&rft.issn=14753898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - intervention; Lipids; heart diseases; opinion leaders; clinical trials; safety engineering; Education; Health care; cholesterol ER - TY - JOUR T1 - A framework for modeling health behavior protocols and their linkage to behavioral theory AN - 19425497; 6645539 AB - With the rise in chronic, behavior-related disease, computerized behavioral protocols (CBPs) that help individuals improve behaviors have the potential to play an increasing role in the future health of society. To be effective and widely used CBPs should be based on accepted behavioral theory. However, designing CBPs while at the same time specifying their linkages to behavioral theory and developing reusable CBP components (interventions) are challenges to developers of CBPs. Having an ontology with which to describe CBPs could help with these issues. As a first step towards creating such an ontology, we modeled PACE-Adolescent, a theory-based behavioral protocol that uses the Stages of Change Model and Social Cognitive Theory, using PROTEGE-2000, an ontology editor and knowledge acquisition system. We created a three-part knowledge model. Two sub-ontologies described behavioral interventions and psychological theories. The third component, implemented using Guideline Interchange Format (GLIF3), provided a way to describe the structure of a protocol and to link intervention resources and groups of actions to elements of psychological theory. Using this framework, we formally described the PACE-Adolescent protocol. Creating knowledge models such as this may lead to improvements in the design and evaluation of computerized health behavior protocols. JF - Journal of Biomedical Informatics AU - Lenert, Leslie AU - Norman, Gregory J AU - Mailhot, Mark AU - Patrick, Kevin AD - Health Services and Research and Development, Veterans Administration San Diego Healthcare System, USA, llenert@ucsd.edu Y1 - 2005/08// PY - 2005 DA - Aug 2005 SP - 270 EP - 280 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 38 IS - 4 SN - 1532-0464, 1532-0464 KW - Biotechnology and Bioengineering Abstracts KW - Cognitive ability KW - Bioinformatics KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19425497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=A+framework+for+modeling+health+behavior+protocols+and+their+linkage+to+behavioral+theory&rft.au=Lenert%2C+Leslie%3BNorman%2C+Gregory+J%3BMailhot%2C+Mark%3BPatrick%2C+Kevin&rft.aulast=Lenert&rft.aufirst=Leslie&rft.date=2005-08-01&rft.volume=38&rft.issue=4&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2004.12.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Models; Cognitive ability; Bioinformatics DO - http://dx.doi.org/10.1016/j.jbi.2004.12.001 ER - TY - JOUR T1 - Hypoechoic areas on ultrasound images of atheroma are not always diagnostic of fatty plaque AN - 19417416; 6648238 AB - Atherosclerotic plaques in ultrasound (US) images may have bright areas suggestive of fibrous plaque and hypoechoic areas that are often interpreted as fatty plaque. The current study was designed to test the hypothesis that fibrous tissue in atherosclerotic plaques will be hyperechoic or hypoechoic, depending on collagen fiber morphology. Twelve segments of aortic arch containing atherosclerotic plaques obtained from cadavers were imaged with an 8-MHz US transducer, then sectioned, stained with picrosirius red and examined with polarized light microscopy. There were 12 bright areas that contained predominantly thick collagen fibers. Two areas were anechoic, with predominantly thin collagen fibers. There were 11 hypoechoic areas; six of these contained thin fibers and five contained no collagen on polarized light microscopy, suggesting fat or thrombus. We conclude that fibrous aortic plaques consisting of predominantly thin fibers appear hypoechoic or anechoic on US images and, therefore, may be indistinguishable from fatty plaques. (E-mail: Premindra.chandraratnaed.va.gov) JF - Ultrasound in Medicine & Biology AU - Tabel, Ghasan M AU - Hepel, Jaroslaw AU - Whittaker, Peter AU - Palal, Betsy AU - Chandraratna, PAnthony AD - Division of Internal Medicine, University of California, Irvine, CA, USA, Premindra.chandraratna@med.va.gov Y1 - 2005/08// PY - 2005 DA - Aug 2005 SP - 1013 EP - 1015 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 31 IS - 8 SN - 0301-5629, 0301-5629 KW - Biotechnology and Bioengineering Abstracts KW - Fibers KW - Aortic arch KW - Aorta KW - Cadavers KW - Plaques KW - Arteriosclerosis KW - Polarized light KW - Ultrasound KW - Collagen KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19417416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Medicine+%26+Biology&rft.atitle=Hypoechoic+areas+on+ultrasound+images+of+atheroma+are+not+always+diagnostic+of+fatty+plaque&rft.au=Tabel%2C+Ghasan+M%3BHepel%2C+Jaroslaw%3BWhittaker%2C+Peter%3BPalal%2C+Betsy%3BChandraratna%2C+PAnthony&rft.aulast=Tabel&rft.aufirst=Ghasan&rft.date=2005-08-01&rft.volume=31&rft.issue=8&rft.spage=1013&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Medicine+%26+Biology&rft.issn=03015629&rft_id=info:doi/10.1016%2Fj.ultrasmedbio.2005.02.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Fibers; Plaques; Collagen; Ultrasound; Arteriosclerosis; Polarized light; Aortic arch; Cadavers; Aorta DO - http://dx.doi.org/10.1016/j.ultrasmedbio.2005.02.008 ER - TY - JOUR T1 - Is impairment in set-shifting specific to frontal-lobe dysfunction? Evidence from patients with frontal-lobe or temporal-lobe epilepsy. AN - 85398586; pmid-16209428 AB - Frontal-lobe epilepsy (FLE), temporal-lobe epilepsy (TLE), and matched-control subjects were administered the Trail Making Test (TMT) of the Delis-Kaplan Executive Function System (D-KEFS; Delis et al., 2001), which assesses set-shifting on a visuomotor sequencing task. Results indicated that patients with FLE were impaired in both speed and accuracy on the switching condition relative to patients with TLE and controls. The two patient groups did not differ from controls on the four baseline conditions of the test, which assess visual scanning, motor speed, number sequencing, and letter sequencing. In addition, seizure-related variables (i.e., age of seizure onset, duration of epilepsy, and seizure frequency) failed to correlate with set-shifting performance in patients with FLE. These results suggest that patients with FLE can be reliably distinguished from those with TLE and control subjects on set-shifting as measured by the DKEFS TMT. JF - Journal of the International Neuropsychological Society : JINS AU - McDonald, Carrie R AU - Delis, Dean C AU - Norman, Marc A AU - Tecoma, Evelyn S AU - Iragui-Madozi, Vicente I AD - Psychology Service (116B) Delis Lab, Veterans Administration San Diego Healthcare System, 3350 La Jolla Village Drive, La Jolla, CA 92611, USA. camcdonald@ucsd.edu Y1 - 2005/07// PY - 2005 DA - Jul 2005 SP - 477 EP - 481 VL - 11 IS - 4 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Analysis of Variance KW - Case-Control Studies KW - Demography KW - *Epilepsy, Frontal Lobe: physiopathology KW - *Epilepsy, Temporal Lobe: physiopathology KW - Female KW - Functional Laterality: physiology KW - Humans KW - Male KW - *Mental Processes: physiology KW - Middle Aged KW - *Psychomotor Performance: physiology KW - Reaction Time: physiology KW - Trail Making Test: statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85398586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Is+impairment+in+set-shifting+specific+to+frontal-lobe+dysfunction%3F+Evidence+from+patients+with+frontal-lobe+or+temporal-lobe+epilepsy.&rft.au=McDonald%2C+Carrie+R%3BDelis%2C+Dean+C%3BNorman%2C+Marc+A%3BTecoma%2C+Evelyn+S%3BIragui-Madozi%2C+Vicente+I&rft.aulast=McDonald&rft.aufirst=Carrie&rft.date=2005-07-01&rft.volume=11&rft.issue=4&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The neuropsychological impact of sports-related concussion: a meta-analysis. AN - 85398516; pmid-16209414 AB - There is increasing interest in the potential neuropsychological impact of sports-related concussion. A meta-analysis of the relevant literature was conducted to determine the impact of sports-related concussion across six cognitive domains. The analysis was based on 21 studies involving 790 cases of concussion and 2014 control cases. The overall effect of concussion (d = 0.49) was comparable to the effect found in the non-sports-related mild traumatic brain injury population (d = 0.54; Belanger et al., 2005). Using sports-concussed participants with a history of prior head injury appears to inflate the effect sizes associated with the current sports-related concussion. Acute effects (within 24 hr of injury) of concussion were greatest for delayed memory, memory acquisition, and global cognitive functioning (d = 1.00, 1.03, and 1.42, respectively). However, no residual neuropsychological impairments were found when testing was completed beyond 7 days postinjury. These findings were moderated by cognitive domain and comparison group (control group versus preconcussion self-control). Specifically, delayed memory in studies utilizing a control group remained problematic at 7 days. The implications and limitations of these findings are discussed. JF - Journal of the International Neuropsychological Society : JINS AU - Belanger, Heather G AU - Vanderploeg, Rodney D AD - James A. Haley Veterans' Hospital, Physical Medicine and Rehabilitation-117, 13000 Bruce B. Downs Blvd., Tampa, FL 33612, USA. Heather.Belanger@med.va.gov Y1 - 2005/07// PY - 2005 DA - Jul 2005 SP - 345 EP - 357 VL - 11 IS - 4 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - *Athletic Injuries: physiopathology KW - Attention: physiology KW - *Brain Concussion: physiopathology KW - *Cognition: physiology KW - Humans KW - Memory: physiology KW - Neuropsychological Tests KW - *Outcome Assessment (Health Care) KW - Retrospective Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85398516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=The+neuropsychological+impact+of+sports-related+concussion%3A+a+meta-analysis.&rft.au=Belanger%2C+Heather+G%3BVanderploeg%2C+Rodney+D&rft.aulast=Belanger&rft.aufirst=Heather&rft.date=2005-07-01&rft.volume=11&rft.issue=4&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Speech signals used to evaluate functional status of the auditory system. AN - 70131287; 16470466 AB - This review presents a brief history of the evolution of speech audiometry from the 1800s to present day. The two-component aspect of hearing loss (audibility and distortion), which was formalized into a framework in past literature, is presented in the context of speech recognition. The differences between speech recognition in quiet and in background noise are discussed as they relate to listeners with normal hearing and listeners with hearing loss. A discussion of the use of sentence materials versus word materials for clinical use is included as is a discussion of the effects of presentation level on recognition performance in quiet and noise. Finally, the effects of age and hearing loss on speech recognition are considered. JF - Journal of rehabilitation research and development AU - Wilson, Richard H AU - McArdle, Rachel AD - James H. Quillen Department of Veterans Affairs (VA) Medical Center, Mountain Home, TN 37684, USA. richard.wilson2@med.va.gov PY - 2005 SP - 79 EP - 94 VL - 42 IS - 4 Suppl 2 KW - Index Medicus KW - Aging -- physiology KW - Speech Perception -- physiology KW - Hearing Aids -- history KW - History, 21st Century KW - History, 20th Century KW - Speech Reception Threshold Test -- history KW - Humans KW - History, 19th Century KW - Noise -- adverse effects KW - Hearing Loss -- physiopathology KW - Audiometry -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70131287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+rehabilitation+research+and+development&rft.atitle=Speech+signals+used+to+evaluate+functional+status+of+the+auditory+system.&rft.au=Wilson%2C+Richard+H%3BMcArdle%2C+Rachel&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2005-07-01&rft.volume=42&rft.issue=4+Suppl+2&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Journal+of+rehabilitation+research+and+development&rft.issn=1938-1352&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-28 N1 - Date created - 2006-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hearing health and care: the need for improved hearing loss prevention and hearing conservation practices. AN - 70129588; 16470464 AB - Hearing loss affects 31 million Americans, particularly veterans who were exposed to harmful levels of noise during military functions. Many veterans also receive treatment with ototoxic medications, which may exacerbate preexisting hearing loss. Thus, hearing loss is the most common and tinnitus the third most common service-connected disability among veterans. Poor implementation of hearing protection programs and a lack of audiometric testing during medical treatment leave veterans vulnerable to unrecognized and untreated hearing loss until speech communication is impaired. Individualized audiometric testing techniques, including assessment of high frequencies, can be used in clinical and occupational settings to detect early hearing loss. Antioxidants also may alleviate cochlear damage caused by noise and ototoxicity. Ultimately, hearing loss prevention requires education on reducing occupational and recreational noise exposure and counseling on the risks and options available to patients. Technological advances will improve monitoring, allow better noise engineering controls, and lead to more effective hearing protection. JF - Journal of rehabilitation research and development AU - Fausti, Stephen A AU - Wilmington, Debra J AU - Helt, Patrick V AU - Helt, Wendy J AU - Konrad-Martin, Dawn AD - Department of Veterans Affairs (VA) Rehabilitation Research and Development Service, National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Portland, OR 97239, USA. stephen.fausti@med.va.gov PY - 2005 SP - 45 EP - 62 VL - 42 IS - 4 Suppl 2 KW - Anti-Infective Agents KW - 0 KW - Antimalarials KW - Antineoplastic Agents KW - Antioxidants KW - Diuretics KW - Index Medicus KW - Antimalarials -- toxicity KW - Health Services Needs and Demand KW - Anti-Infective Agents -- toxicity KW - Audiometry KW - Humans KW - Counseling KW - Risk Assessment KW - Diuretics -- toxicity KW - Veterans KW - Otoacoustic Emissions, Spontaneous KW - Risk Factors KW - Antioxidants -- therapeutic use KW - Antineoplastic Agents -- toxicity KW - Environmental Exposure KW - Evoked Potentials, Auditory KW - Incidence KW - United States -- epidemiology KW - Tinnitus -- prevention & control KW - Hearing Loss -- diagnosis KW - Tinnitus -- diagnosis KW - Hearing Loss -- epidemiology KW - Tinnitus -- etiology KW - Tinnitus -- epidemiology KW - Hearing Loss -- etiology KW - Hearing Loss -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70129588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+rehabilitation+research+and+development&rft.atitle=Hearing+health+and+care%3A+the+need+for+improved+hearing+loss+prevention+and+hearing+conservation+practices.&rft.au=Fausti%2C+Stephen+A%3BWilmington%2C+Debra+J%3BHelt%2C+Patrick+V%3BHelt%2C+Wendy+J%3BKonrad-Martin%2C+Dawn&rft.aulast=Fausti&rft.aufirst=Stephen&rft.date=2005-07-01&rft.volume=42&rft.issue=4+Suppl+2&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Journal+of+rehabilitation+research+and+development&rft.issn=1938-1352&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-28 N1 - Date created - 2006-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuropsychological aspects of coinfection with HIV and hepatitis C virus. AN - 68753445; 16265612 AB - Infection with hepatitis C virus (HCV) is commonly seen in persons with human immunodeficiency virus (HIV) infection, because the viruses share risk factors for transmission; coinfection is a leading cause of morbidity and mortality among HIV-infected persons. Neuropsychological consequences of HIV infection are well established, and studies of HCV-infected persons have revealed neuropsychiatric dysfunction in this population as well. Investigators now are focusing on neuropsychological sequelae of coinfection with HIV and HCV, and preliminary results suggest that coinfection has a possible deleterious effect on global cognitive functioning consistent with frontal-subcortical dysfunction. Data on neuropsychiatric symptoms in coinfected persons are inconclusive at this time and are complicated by important differences in study populations (e.g., injection drug use and disease severity). This review summarizes what is known about neuropsychological aspects of monoinfection with HIV and HCV, as well as coinfection, discusses implications of these findings, and suggests future directions for this research area. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Hilsabeck, Robin C AU - Castellon, Steven A AU - Hinkin, Charles H AD - Psychology Service, South Texas Veterans Health Care System, San Antonio, TX 78229-4404, USA. Robin.Hilsabeck@med.va.gov Y1 - 2005/07/01/ PY - 2005 DA - 2005 Jul 01 SP - S38 EP - S44 VL - 41 Suppl 1 KW - Index Medicus KW - Frontal Lobe -- physiopathology KW - Cognition -- physiology KW - Humans KW - Mental Disorders -- virology KW - Substance-Related Disorders -- complications KW - Frontal Lobe -- chemistry KW - Psychomotor Performance -- physiology KW - HIV Infections -- physiopathology KW - HIV Infections -- complications KW - Cognition Disorders -- virology KW - Hepatitis C -- complications KW - Hepatitis C -- psychology KW - HIV Infections -- psychology KW - Hepatitis C -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68753445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Neuropsychological+aspects+of+coinfection+with+HIV+and+hepatitis+C+virus.&rft.au=Hilsabeck%2C+Robin+C%3BCastellon%2C+Steven+A%3BHinkin%2C+Charles+H&rft.aulast=Hilsabeck&rft.aufirst=Robin&rft.date=2005-07-01&rft.volume=41+Suppl+1&rft.issue=&rft.spage=S38&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-15 N1 - Date created - 2005-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Exp Neuropsychol. 2000 Feb;22(1):16-24 [10649542] Psychiatr Serv. 2000 Feb;51(2):234-8 [10655009] Am J Psychiatry. 2000 May;157(5):683-94 [10784457] J Int Neuropsychol Soc. 2000 Mar;6(3):336-47 [10824505] Am J Psychiatry. 2000 Jun;157(6):867-76 [10831463] Psychosomatics. 2000 Sep-Oct;41(5):377-84 [11015623] N Engl J Med. 2001 Jul 5;345(1):41-52 [11439948] Lancet. 2001 Jul 7;358(9275):38-9 [11454379] Psychosomatics. 2001 Sep-Oct;42(5):411-5 [11739908] Hepatology. 2002 Feb;35(2):433-9 [11826420] Hepatology. 2002 Feb;35(2):440-6 [11826421] J Hepatol. 2002 Mar;36(3):401-7 [11867185] J Hepatol. 2002 Mar;36(3):435-8 [11867190] Gastroenterology. 2002 Aug;123(2):476-82 [12145801] J Hepatol. 2002 Sep;37(3):349-54 [12175630] Psychother Psychosom. 2002 Nov-Dec;71(6):342-9 [12411769] Am J Psychiatry. 2003 Jan;160(1):172-4 [12505819] Psychiatr Serv. 2003 Jun;54(6):827-35 [12773596] J Int Neuropsychol Soc. 2003 Sep;9(6):847-54 [14632243] Psychosomatics. 2004 Jan-Feb;45(1):49-57 [14709760] J Acquir Immune Defic Syndr. 2004 Feb 1;35(2):131-7 [14722444] J Int Neuropsychol Soc. 2004 Jan;10(1):110-3 [14751013] Infection. 2004 Feb;32(1):33-46 [15007741] J Int Neuropsychol Soc. 2004 Mar;10(2):298-300 [15012850] Neurology. 2004 Mar 23;62(6):957-62 [15037699] AIDS. 2004 Jan 2;18(1):1-12 [15090824] Blood. 2004 May 15;103(10):3854-9 [14739225] Ann Neurol. 1986 Jun;19(6):525-35 [3014994] Neurology. 1992 Oct;42(10):1924-30 [1407574] Acta Neurol Scand. 1993 Aug;88(2):112-8 [8213054] J Neuropsychiatry Clin Neurosci. 1995 Spring;7(2):180-7 [7626961] Addict Behav. 1995 Sep-Oct;20(5):685-90 [8712065] Compr Psychiatry. 1997 May-Jun;38(3):146-54 [9154370] J Int Neuropsychol Soc. 1995 May;1(3):304-15 [9375225] J Int Neuropsychol Soc. 1995 Nov;1(6):575-80 [9375245] J Neuropsychiatry Clin Neurosci. 1998 Summer;10(3):320-9 [9706540] Neurology. 1999 Jan 1;52(1):100-8 [9921855] J Int Neuropsychol Soc. 1999 Jan;5(1):41-7 [9989023] Am J Gastroenterol. 1999 May;94(5):1355-60 [10235218] Neuropsychology. 1999 Apr;13(2):306-16 [10353380] Hepatology. 1999 Oct;30(4):1054-8 [10498659] J Virol. 1999 Nov;73(11):9213-21 [10516029] J Int Neuropsychol Soc. 2005 Jan;11(1):16-22 [15686604] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Deterioration following alcohol-use disorder treatment in project MATCH. AN - 68715117; 16240559 AB - This study examines the prevalence and predictors of deterioration during the three months following treatment in Project MATCH (Matching Alcoholism Treatments to Client Heterogeneity), a multisite clinical trial of three different treatments for alcohol-use disorders. The outpatient and aftercare samples of Project MATCH were examined to identify the prevalence of deterioration, as reflected by a decline in percent days abstinent between the 3 months prior to baseline and the 3 months immediately following treatment. Analyses of predictors of deterioration were based on baseline sociodemographic and psychological factors, including substance-related and psychiatric symptoms and treatment-related factors, including treatment type, treatment duration and therapeutic alliance. Approximately 10% (91/927) of patients in the outpatient sample and 7% (50/738) of patients in the aftercare sample deteriorated in the 3 months following treatment. Primary predictors of deterioration in the outpatient sample were lower baseline severity of alcohol dependence, higher baseline depression, fewer sessions of treatment and lower ratings of therapeutic alliance. The only factor associated with deterioration in the aftercare sample was fewer sessions of treatment. Despite the general positive response of patients to alcohol-use disorder treatment, researchers and treatment providers need to be aware of the potential for deterioration in a sizable minority of patients. Potential methods for identifying patients at risk for deterioration early in treatment are discussed. JF - Journal of studies on alcohol AU - Ilgen, Mark AU - Moos, Rudolf AD - Centerfor Health Care Evaluation, Department of Veterans Affairs, Palo Alto Health Care System and Stanford University School of Medicine, 795 Willow Road (MPD 152), Menlo Park, CA 94025, USA. Mark.Ilgen@med.va.gov Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 517 EP - 525 VL - 66 IS - 4 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Socioeconomic Factors KW - Demography KW - Treatment Failure KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Temperance KW - Male KW - Female KW - Prevalence KW - Alcoholism -- epidemiology KW - Alcoholism -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68715117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Deterioration+following+alcohol-use+disorder+treatment+in+project+MATCH.&rft.au=Ilgen%2C+Mark%3BMoos%2C+Rudolf&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2005-07-01&rft.volume=66&rft.issue=4&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic determinants of addiction to opioids and cocaine. AN - 68524660; 16126608 AB - The completion of the human genome sequence has spurred investigation of the genetic contribution to substance dependence. In this article some of the recent scientific evidence for genetic determinants of opioid and cocaine dependence is reviewed. An electronic search of the medical literature was conducted to locate published studies relevant to the genetics of opioid and cocaine dependence. The collected information judged to be most pertinent is described and discussed. Genetic epidemiologic studies support a high degree of heritable vulnerability for both opioid and cocaine dependence. Polymorphisms in the genes coding for dopamine receptors and transporter, opioid receptors, endogenous opioid peptides, cannabinoid receptors, and serotonin receptors and transporter all appear to be associated with the phenotypic expression of this vulnerability once opioids or cocaine are consumed. Despite this initial progress, identification of specific genes and quantification of associated risk for the expression of each gene remain to be elucidated. While alteration of an individual's genome to change the phenotype seems remote, future interventions for treatment of opioid and cocaine dependence may include precise medications targeted to block the effects of proteins that have been identified through genetic research. JF - Harvard review of psychiatry AU - Saxon, Andrew J AU - Oreskovich, Michael R AU - Brkanac, Zoran AD - Department of Psychiatry, University of Washington School of Medicine; Center of Excellence in Substance Abuse Treatment and Education, VA Puget Sound Health Care System, Seattle, WA 98108, USA. Andrew.Saxon@med.va.gov PY - 2005 SP - 218 EP - 232 VL - 13 IS - 4 SN - 1067-3229, 1067-3229 KW - Dopamine Plasma Membrane Transport Proteins KW - 0 KW - Receptors, Dopamine KW - Receptors, Opioid KW - Index Medicus KW - Dopamine Plasma Membrane Transport Proteins -- genetics KW - Polymorphism, Genetic -- genetics KW - Humans KW - Receptors, Dopamine -- genetics KW - Receptors, Opioid -- genetics KW - Gene Library KW - Cocaine-Related Disorders -- genetics KW - Opioid-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68524660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Harvard+review+of+psychiatry&rft.atitle=Genetic+determinants+of+addiction+to+opioids+and+cocaine.&rft.au=Saxon%2C+Andrew+J%3BOreskovich%2C+Michael+R%3BBrkanac%2C+Zoran&rft.aulast=Saxon&rft.aufirst=Andrew&rft.date=2005-07-01&rft.volume=13&rft.issue=4&rft.spage=218&rft.isbn=&rft.btitle=&rft.title=Harvard+review+of+psychiatry&rft.issn=10673229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-03 N1 - Date created - 2005-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Recent advances in alcohol-induced adduct formation. AN - 68455855; 16088993 JF - Alcoholism, clinical and experimental research AU - Freeman, Thomas L AU - Tuma, Dean J AU - Thiele, Geoffrey M AU - Klassen, Lynell W AU - Worrall, Simon AU - Niemelä, Onni AU - Parkkila, Seppo AU - Emery, Peter W AU - Preedy, Victor R Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 1310 EP - 1316 VL - 29 IS - 7 KW - DNA Adducts KW - 0 KW - Ethanol KW - 3K9958V90M KW - Malondialdehyde KW - 4Y8F71G49Q KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Malondialdehyde -- metabolism KW - Alcohol-Related Disorders -- physiopathology KW - Animals KW - Liver -- physiopathology KW - Cardiomyopathy, Alcoholic -- physiopathology KW - Humans KW - Muscle, Skeletal -- physiopathology KW - Liver Diseases, Alcoholic -- physiopathology KW - Myocardium -- metabolism KW - Muscular Diseases -- physiopathology KW - DNA Adducts -- physiology KW - Lipid Peroxidation -- drug effects KW - Acetaldehyde -- toxicity KW - Ethanol -- toxicity KW - Acetaldehyde -- metabolism KW - Ethanol -- metabolism KW - Alcoholism -- physiopathology KW - DNA Adducts -- drug effects KW - Lipid Peroxidation -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68455855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Recent+advances+in+alcohol-induced+adduct+formation.&rft.au=Freeman%2C+Thomas+L%3BTuma%2C+Dean+J%3BThiele%2C+Geoffrey+M%3BKlassen%2C+Lynell+W%3BWorrall%2C+Simon%3BNiemel%C3%A4%2C+Onni%3BParkkila%2C+Seppo%3BEmery%2C+Peter+W%3BPreedy%2C+Victor+R&rft.aulast=Freeman&rft.aufirst=Thomas&rft.date=2005-07-01&rft.volume=29&rft.issue=7&rft.spage=1310&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-11 N1 - Date created - 2005-08-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A temporal and dose-response association between alcohol consumption and medication adherence among veterans in care. AN - 68082724; 16046874 AB - Previous studies have shown that alcohol consumption is associated with decreased medication adherence, but this association may be confounded by characteristics common among those who drink heavily and those who fail to adhere (e.g., illicit drug use). Our objective was to determine whether there are temporal and dose-response relationships between alcohol consumption and poor adherence. We administered telephone interview surveys to participants in the Veterans Aging Cohort Study, an eight-site observational study of HIV+ and matched HIV- veterans in care, to determine whether alcohol consumption on a particular day was associated with nonadherence to prescribed medications on that same day. We used the Time Line Follow Back to measure alcohol consumption and the Time Line Follow Back Modified for Adherence to measure adherence. Individuals were categorized as abstainers (no alcohol in past 30 days), nonbinge drinkers (alcohol in past 30 days but or =five standard drinks on at least one day). Among 2702 respondents, 1582 (56.6%) were abstainers, 931 (34.5%) were nonbinge drinkers, and 239 (8.9%) were binge drinkers. Abstainers missed medication doses on 2.4% of surveyed days. Nonbinge drinkers missed doses on 3.5% of drinking days, 3.1% of postdrinking days, and 2.1% of nondrinking days (p < 0.001 for trend), and this trend was more pronounced among HIV+ individuals than HIV- individuals. Binge drinkers missed doses on 11.0% of drinking days, 7.0% of postdrinking days, and 4.1% of nondrinking days (p < 0.001 for trend), and this trend was comparably strong for HIV+ and HIV- individuals. Among veterans in care, self-reported alcohol consumption demonstrates a temporal and dose-response relationship to poor adherence. HIV+ individuals may be particularly sensitive to alcohol consumption. JF - Alcoholism, clinical and experimental research AU - Braithwaite, R Scott AU - McGinnis, Kathleen A AU - Conigliaro, Joseph AU - Maisto, Stephen A AU - Crystal, Stephen AU - Day, Nancy AU - Cook, Robert L AU - Gordon, Adam AU - Bridges, Michael W AU - Seiler, Jason F S AU - Justice, Amy C AD - West Haven Veterans Administration Medical Center and Yale University School of Medicine, West Haven, Connecticut 06516, USA. Ronald.brathwaite@med.va.gov Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 1190 EP - 1197 VL - 29 IS - 7 SN - 0145-6008, 0145-6008 KW - Anti-HIV Agents KW - 0 KW - Index Medicus KW - Humans KW - Cohort Studies KW - Interviews as Topic KW - Middle Aged KW - Statistics as Topic KW - Longitudinal Studies KW - Alcoholism -- psychology KW - Male KW - Female KW - HIV Seropositivity -- psychology KW - Veterans -- psychology KW - Anti-HIV Agents -- administration & dosage KW - Alcohol Drinking -- psychology KW - Alcohol Drinking -- adverse effects KW - HIV Seropositivity -- drug therapy KW - Treatment Refusal -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68082724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=A+temporal+and+dose-response+association+between+alcohol+consumption+and+medication+adherence+among+veterans+in+care.&rft.au=Braithwaite%2C+R+Scott%3BMcGinnis%2C+Kathleen+A%3BConigliaro%2C+Joseph%3BMaisto%2C+Stephen+A%3BCrystal%2C+Stephen%3BDay%2C+Nancy%3BCook%2C+Robert+L%3BGordon%2C+Adam%3BBridges%2C+Michael+W%3BSeiler%2C+Jason+F+S%3BJustice%2C+Amy+C&rft.aulast=Braithwaite&rft.aufirst=R&rft.date=2005-07-01&rft.volume=29&rft.issue=7&rft.spage=1190&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-11 N1 - Date created - 2005-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Madarosis and facial alopecia presumed secondary to botulinum a toxin injections. AN - 68078131; 16044070 AB - : Botulinum neurotoxins are considered relatively safe therapy for treatment of inappropriate muscle spasms. As seen in this report, undesirable consequences may result. : The author conducted a clinical interview and examination of the patient. : Unilateral left-sided madarosis and facial alopecia were observed in a patient undergoing botulinum A toxin injections for the treatment of left oromandibular dystonia. The patient had started treatment 18 months previously. He received injections every 3 months in the left masseter and left temporalis muscles. He first noted loss of his left sideburn 8 months into treatment. After 10 months of treatment, he noted that he no longer needed to shave on the left side of his face. Eighteen months after receiving his first botulinum toxin injection, madarosis of the temporal aspect of the left lower lid was observed. : This is the first case report documenting an idiosyncratic unilateral madarosis and facial alopecia as adverse side effects presumed secondary to botulinum A toxin injections. JF - Optometry and vision science : official publication of the American Academy of Optometry AU - Kowing, Dianne AD - William Chappell Jr. VA Outpatient Clinic, Daytona Beach, FL 32114-1495, USA. Diane.Dowing@med.va.gov Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 579 EP - 582 VL - 82 IS - 7 SN - 1040-5488, 1040-5488 KW - Anti-Dyskinesia Agents KW - 0 KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Index Medicus KW - Humans KW - Injections -- adverse effects KW - Middle Aged KW - Mandibular Diseases -- drug therapy KW - Dystonia -- drug therapy KW - Visual Acuity KW - Male KW - Botulinum Toxins -- administration & dosage KW - Anti-Dyskinesia Agents -- adverse effects KW - Anti-Dyskinesia Agents -- administration & dosage KW - Botulinum Toxins -- adverse effects KW - Eyelid Diseases -- chemically induced KW - Alopecia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68078131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Optometry+and+vision+science+%3A+official+publication+of+the+American+Academy+of+Optometry&rft.atitle=Madarosis+and+facial+alopecia+presumed+secondary+to+botulinum+a+toxin+injections.&rft.au=Kowing%2C+Dianne&rft.aulast=Kowing&rft.aufirst=Dianne&rft.date=2005-07-01&rft.volume=82&rft.issue=7&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Optometry+and+vision+science+%3A+official+publication+of+the+American+Academy+of+Optometry&rft.issn=10405488&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-13 N1 - Date created - 2005-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Manganese superoxide dismutase and inducible nitric oxide synthase modify early oxidative events in acute adriamycin-induced mitochondrial toxicity. AN - 68039046; 16020663 AB - In the present study, we used genetically engineered B6C3 mice [mice overexpressing manganese superoxide dismutase (TgM(+/+)), mice in which inducible nitric oxide synthase had been inactivated (iNOSKO(-/-)), and crosses of these two genotypes] to study the role of manganese superoxide dismutase (MnSOD) and inducible nitric oxide synthase (iNOS) in the development of acute Adriamycin-induced cardiotoxicity. Both nontransgenic and genetically engineered mice were treated with 20 mg/kg Adriamycin and cardiac left ventricular tissues studied at 0, 3, 6, and 24 hours. Ultrastructural damage and levels of 4-hydroxy-2-nonenal (4HNE) protein adducts and 3-nitrotyrosine (3NT) were determined in cardiomyocytes using immunogold ultrastructural techniques. Our previous results showed that Adriamycin caused mitochondrial injury without significant nuclear or cytoplasmic damage at early time points. Interestingly, overexpression of MnSOD protected against acute mitochondrial injury, whereas deficiency in iNOS potentiated mitochondrial injury in comparison with levels of injury present in cardiomyocyte mitochondria of nontransgenic mice. In TgM(+/+) mice, there was a significant inverse correlation between mitochondrial injury and 4HNE/3NT levels at all time points analyzed, suggesting that reactive oxygen species/reactive nitrogen species damage products directly regulated acute Adriamycin-induced mitochondrial injury in these mice. The present studies are the first to directly quantify the effects of MnSOD and iNOS on mitochondrial injury during acute Adriamycin-induced cardiotoxicity and show extensive and specific patterns of posttranslational modifications of mitochondrial proteins following Adriamycin treatment. JF - Molecular cancer therapeutics AU - Chaiswing, Luksana AU - Cole, Marsha P AU - Ittarat, Wanida AU - Szweda, Luke I AU - St Clair, Daret K AU - Oberley, Terry D AD - Department of Pathology and Laboratory Medicine, William S. Middleton Memorial Veterans Administration Hospital, Madison, WI 53705, USA. Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 1056 EP - 1064 VL - 4 IS - 7 SN - 1535-7163, 1535-7163 KW - Actins KW - 0 KW - Aldehydes KW - Nitrates KW - Reactive Oxygen Species KW - 3-nitrotyrosine KW - 3604-79-3 KW - Tyrosine KW - 42HK56048U KW - Doxorubicin KW - 80168379AG KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - 4-hydroxy-2-nonenal KW - K1CVM13F96 KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Myocytes, Cardiac -- drug effects KW - Aldehydes -- analysis KW - Actins -- drug effects KW - Actins -- metabolism KW - Mice KW - Myocytes, Cardiac -- pathology KW - Nitrates -- blood KW - Mice, Inbred Strains KW - Blotting, Western KW - Mice, Mutant Strains KW - Blotting, Southern KW - Aldehydes -- metabolism KW - Tyrosine -- metabolism KW - Tyrosine -- analogs & derivatives KW - Male KW - Oxidative Stress KW - Superoxide Dismutase -- metabolism KW - Superoxide Dismutase -- genetics KW - Mitochondria, Heart -- drug effects KW - Superoxide Dismutase -- drug effects KW - Doxorubicin -- toxicity KW - Mitochondria, Heart -- metabolism KW - Mitochondria, Heart -- ultrastructure KW - Mitochondria, Heart -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68039046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Manganese+superoxide+dismutase+and+inducible+nitric+oxide+synthase+modify+early+oxidative+events+in+acute+adriamycin-induced+mitochondrial+toxicity.&rft.au=Chaiswing%2C+Luksana%3BCole%2C+Marsha+P%3BIttarat%2C+Wanida%3BSzweda%2C+Luke+I%3BSt+Clair%2C+Daret+K%3BOberley%2C+Terry+D&rft.aulast=Chaiswing&rft.aufirst=Luksana&rft.date=2005-07-01&rft.volume=4&rft.issue=7&rft.spage=1056&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-23 N1 - Date created - 2005-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improving the rates of quitting smoking for veterans with posttraumatic stress disorder. AN - 67991238; 15994714 AB - Smoking is highly prevalent and refractory among people with posttraumatic stress disorder (PTSD). This study aimed to improve the rate of quitting smoking for veterans with PTSD by integrating treatment for nicotine dependence into mental health care. Smokers undergoing treatment for PTSD (N=66) were randomly assigned to 1) tobacco use treatment delivered by mental health providers and integrated with psychiatric care (integrated care) versus 2) cessation treatment delivered separately from PTSD care by smoking-cessation specialists (usual standard of care). Seven-day point prevalence abstinence was the primary outcome, measured at 2, 4, 6, and 9 months after random assignment. Data were analyzed by using a generalized estimating equations approach following the intent-to-treat principle. Subjects assigned to integrated care were five times more likely than subjects undergoing the usual standard of care to abstain from smoking across follow-up assessment intervals (odds ratio=5.23). Subjects in the integrated care condition were significantly more likely than subjects in usual standard of care to receive transdermal nicotine and nicotine gum. They also received a greater number of smoking-cessation counseling sessions. Stopping smoking was not associated with worsening symptoms of PTSD or depression. Smoking-cessation interventions can be safely incorporated into routine mental health care for PTSD and are more effective than treatment delivered separately by a specialized smoking-cessation clinic. Integrating cessation treatment into psychiatric care may have the potential for improving smoking quit rates in other populations of chronically mentally ill smokers. JF - The American journal of psychiatry AU - McFall, Miles AU - Saxon, Andrew J AU - Thompson, Charles E AU - Yoshimoto, Dan AU - Malte, Carol AU - Straits-Troster, Kristy AU - Kanter, Evan AU - Zhou, Xiao-Hua Andrew AU - Dougherty, Cynthia M AU - Steele, Bonnie AD - PTSD Programs (S-116 MHC), VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA 98108, USA. miles.mcfall@med.va.gov Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 1311 EP - 1319 VL - 162 IS - 7 SN - 0002-953X, 0002-953X KW - Psychotropic Drugs KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Patient Satisfaction KW - Combined Modality Therapy KW - Tobacco Use Disorder -- therapy KW - Tobacco Use Disorder -- epidemiology KW - Humans KW - Psychotropic Drugs -- therapeutic use KW - Psychotherapy -- methods KW - Comorbidity KW - Quality Assurance, Health Care KW - Treatment Outcome KW - Tobacco Use Disorder -- psychology KW - Follow-Up Studies KW - Middle Aged KW - Female KW - Male KW - Prevalence KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Stress Disorders, Post-Traumatic -- therapy KW - Stress Disorders, Post-Traumatic -- psychology KW - Veterans -- psychology KW - Smoking Cessation -- methods KW - Smoking -- prevention & control KW - Smoking -- epidemiology KW - Smoking Cessation -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67991238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Improving+the+rates+of+quitting+smoking+for+veterans+with+posttraumatic+stress+disorder.&rft.au=McFall%2C+Miles%3BSaxon%2C+Andrew+J%3BThompson%2C+Charles+E%3BYoshimoto%2C+Dan%3BMalte%2C+Carol%3BStraits-Troster%2C+Kristy%3BKanter%2C+Evan%3BZhou%2C+Xiao-Hua+Andrew%3BDougherty%2C+Cynthia+M%3BSteele%2C+Bonnie&rft.aulast=McFall&rft.aufirst=Miles&rft.date=2005-07-01&rft.volume=162&rft.issue=7&rft.spage=1311&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-17 N1 - Date created - 2005-07-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A phase II study of flavopiridol in patients with advanced renal cell carcinoma: results of Southwest Oncology Group Trial 0109. AN - 67805490; 15791454 AB - Flavopiridol is a cyclin-dependent kinase inhibitor that prevents cell cycle progression and tumor growth. In initial phase I studies, encouraging responses were seen in advanced renal cell cancer (RCC). In a phase II study of flavopiridol given as a 72-h continuous infusion every 2 weeks in RCC, a response rate of 6% was seen but with considerable grade 3 or 4 asthenia, diarrhea, and thrombosis. Subsequently, an alternative 1-h bolus schedule was reported to have enhanced tolerability in a phase I trial. We therefore conducted a phase II study of this bolus regimen. A total of 38 patients with advanced RCC were entered into this multi-institutional phase II study. Flavopiridol (50 mg/m(2) per day) was administered by bolus intravenous injection daily for three consecutive days, repeated every 3 weeks. Out of 34 eligible patients, one complete response and three partial responses were observed, for an overall response rate of 12% (95% CI 3-27%). Of the 34 patients, 14 (41%) had stable disease (SD). The probability of not failing treatment by 6 months was 21% (95% CI 9-35%). Median overall survival time was 9 months (95% CI 8-18 months). The most common grade 3 or 4 toxicities were diarrhea (35%) and tumor pain (12%) along with anemia, dyspnea, and fatigue (9% each). Flavopiridol at this dose and schedule is feasible with an acceptable toxicity profile. Flavopiridol has some modest biologic activity against advanced RCC, as evidenced by its single-agent objective response and SD rates. JF - Cancer chemotherapy and pharmacology AU - Van Veldhuizen, Peter J AU - Faulkner, James R AU - Lara, Primo N AU - Gumerlock, Paul H AU - Goodwin, J Wendall AU - Dakhil, Shaker R AU - Gross, Howard M AU - Flanigan, Robert C AU - Crawford, E David AU - Southwest Oncology Group AD - University of Kansas Medical Center, Kansas City, KS, USA. peter.vanveldhuizen@med.va.gov ; Southwest Oncology Group Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 39 EP - 45 VL - 56 IS - 1 SN - 0344-5704, 0344-5704 KW - Antineoplastic Agents KW - 0 KW - Flavonoids KW - Piperidines KW - alvocidib KW - 45AD6X575G KW - Index Medicus KW - Drug Administration Schedule KW - Diarrhea -- chemically induced KW - Injections, Intravenous KW - Pain -- chemically induced KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Male KW - Female KW - Survival Analysis KW - Carcinoma, Renal Cell -- pathology KW - Kidney Neoplasms -- pathology KW - Kidney Neoplasms -- drug therapy KW - Piperidines -- therapeutic use KW - Antineoplastic Agents -- administration & dosage KW - Flavonoids -- adverse effects KW - Piperidines -- administration & dosage KW - Carcinoma, Renal Cell -- drug therapy KW - Antineoplastic Agents -- therapeutic use KW - Piperidines -- adverse effects KW - Flavonoids -- therapeutic use KW - Flavonoids -- administration & dosage KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67805490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=A+phase+II+study+of+flavopiridol+in+patients+with+advanced+renal+cell+carcinoma%3A+results+of+Southwest+Oncology+Group+Trial+0109.&rft.au=Van+Veldhuizen%2C+Peter+J%3BFaulkner%2C+James+R%3BLara%2C+Primo+N%3BGumerlock%2C+Paul+H%3BGoodwin%2C+J+Wendall%3BDakhil%2C+Shaker+R%3BGross%2C+Howard+M%3BFlanigan%2C+Robert+C%3BCrawford%2C+E+David%3BSouthwest+Oncology+Group&rft.aulast=Van+Veldhuizen&rft.aufirst=Peter&rft.date=2005-07-01&rft.volume=56&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=03445704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-05 N1 - Date created - 2005-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Influence of Partner Status, Relationship Quality and Relationship Stability on Outcomes Following Intensive Substance-Use Disorder Treatment AN - 57089067; 200600866 AB - Objective: Addiction treatment studies examining the influence of patients' partners suggest that partner behaviors affect patients' substance-use outcomes. We examine the influence of having a partner at treatment entry as well as the influence of the general quality of support and substance-using status of the partner, on outcomes following treatment for substance-use disorder. We also examine the influence of relationship stability on treatment outcomes and examine baseline partner behaviors that may predict relationship stability. Method: A prospective, intact-group design was utilized with data analyzed using logistic regression. Participants (N = 3,014) from 15 intensive substance-use disorder treatment programs were assessed at treatment entry and 1-year postdischarge. Results: Although patients with partners possessed a more favorable clinical profile, their outcomes were no better than those of their single counterparts. However, patients whose relationships lasted through the first year posttreatment had better outcomes than patients whose relationships ended. Relationships with more positive partner behaviors and fewer negative partner behaviors at intake were more likely to remain intact over the course of the first year posttreatment. Positive partner behaviors did not enhance patients' outcomes directly, but partner interpersonal stressors and patients' belief that their partner had a substance-use problem had a significant, deleterious impact on patients' substance-use outcomes. Conclusions: Clinicians should routinely assess the quality of patients' relationships with partners. If deleterious partner behaviors exist, empirically supported interventions (e.g., behavioral couples therapy) could be utilized to reduce these behaviors and ultimately reduce relapse risk. Tables, References. Adapted from the source document. JF - Journal of Studies on Alcohol AU - Tracy, Stephen W AU - Kelly, John F AU - Moos, Rudolf H AD - Center Health Care Evaluation, Veterans Affairs Palo Alto Health Care System, Stanford U School of Medicine, stephen.tracy@med.va.gov Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 497 EP - 505 VL - 66 IS - 4 SN - 0096-882X, 0096-882X KW - Quality assessment KW - Interpersonal relationships KW - Interventions KW - Addiction KW - Treatment KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57089067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol&rft.atitle=The+Influence+of+Partner+Status%2C+Relationship+Quality+and+Relationship+Stability+on+Outcomes+Following+Intensive+Substance-Use+Disorder+Treatment&rft.au=Tracy%2C+Stephen+W%3BKelly%2C+John+F%3BMoos%2C+Rudolf+H&rft.aulast=Tracy&rft.aufirst=Stephen&rft.date=2005-07-01&rft.volume=66&rft.issue=4&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JSALDP N1 - SubjectsTermNotLitGenreText - Interventions; Treatment; Addiction; Interpersonal relationships; Substance abuse; Quality assessment ER - TY - JOUR T1 - Septicemia, access and cardiovascular disease in dialysis patients: The USRDS Wave 2 Study AN - 19286838; 6405809 AB - Background. Microinflammation is linked to cardiovascular disease, and is highly prevalent in dialysis patients. It is logical to postulate that septicemia, a common macroinflammatory occurrence in dialysis patients, contributes to their large burden of cardiovascular disease. Methods. The Dialysis Morbidity and Mortality Wave 2 was a randomly selected prospective cohort of incident dialysis patients. Admission claims data were used to define and calculate rates of septicemia or bacteremia and cardiovascular events in those with Medicare as the primary payer. Utilizing Cox proportional hazard models we determined the association between baseline access and the development of bacteremia or sepsis, and also the association between bacteremia or sepsis episodes and subsequent cardiovascular events. Results. The 2358 (59%) patients with Medicare as primary payer were older and more likely to have heart failure than those with other payers, but had similar comorbidity-adjusted mortality hazards. Rates of first septicemia, bacteremia, or either condition, were 7.0, 5.9 and 10.4 events per 100-patient years, respectively. Cox regression identified initial dialysis access as the main antecedent of septicemia or bacteremia. Hazards ratios for hemodialysis with permanent catheters, temporary catheters, and grafts were 1.95 (95% CI 1.47-2.57), 1.76 (95% CI 1.29-2.41), and 1.05 (95% CI 0.82-1.35), respectively, while that for peritoneal dialysis was 0.96 (95% CI 0.75-1.23) (reference arteriovenous fistula). After adjustment for baseline factors, septicemia or bacteremia, as a time-dependent covariate, was associated with subsequent death [hazards ratio (HR) 2.33, 95% CI 1.38-2.28], myocardial infarction (HR 1.78, 95% CI 1.38-2.28), heart failure (HR 1.64, 95% CI 1.39-1.95), peripheral vascular disease (HR 1.64, 95% CI 1.34-2.0), and stroke (HR 2.04, 95% CI 1.27-3.28). Conclusion. Septicemia appears to be an important, potentially preventable, cardiovascular risk factor in dialysis patients. JF - Kidney International AU - Ishani, Areef AU - Collins, Allan J AU - Herzog, Charles A AU - Foley, Robert N AD - Areef Ishani, Division of Nephrology (111J), Department of Medicine, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, areef.ishani@med.va.gov Y1 - 2005/07// PY - 2005 DA - Jul 2005 SP - 311 EP - 318 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 68 IS - 1 SN - 0085-2538, 0085-2538 KW - Microbiology Abstracts B: Bacteriology KW - Mortality KW - Data processing KW - Septicemia KW - Peritoneum KW - Stroke KW - Bacteremia KW - Hemodialysis KW - Vascular diseases KW - Morbidity KW - Myocardial infarction KW - Models KW - Sepsis KW - Risk factors KW - Kidney KW - Catheters KW - Waves KW - Cardiovascular diseases KW - Heart diseases KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19286838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+International&rft.atitle=Septicemia%2C+access+and+cardiovascular+disease+in+dialysis+patients%3A+The+USRDS+Wave+2+Study&rft.au=Ishani%2C+Areef%3BCollins%2C+Allan+J%3BHerzog%2C+Charles+A%3BFoley%2C+Robert+N&rft.aulast=Ishani&rft.aufirst=Areef&rft.date=2005-07-01&rft.volume=68&rft.issue=1&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Kidney+International&rft.issn=00852538&rft_id=info:doi/10.1111%2Fj.1523-1755.2005.00414.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - SuppNotes - Figures, 3; tables, 4; formulas, 11; references, 49. N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; Septicemia; Stroke; Peritoneum; Bacteremia; Vascular diseases; Hemodialysis; Myocardial infarction; Morbidity; Models; Sepsis; Risk factors; Catheters; Kidney; Waves; Cardiovascular diseases; Heart diseases DO - http://dx.doi.org/10.1111/j.1523-1755.2005.00414.x ER - TY - JOUR T1 - Cochlear function in mice following inhalation of brevetoxin-3 AN - 17661155; 6525056 AB - Brevetoxin-3 was shown previously to adversely affect central auditory function in goldfish. The present study evaluated the effects of exposure to this agent on cochlear function in mice using the 2f sub(1)-f sub(2) distortion-product otoacoustic emission (DPOAE). Towards this end, inbred CBA/CaJ mice were exposed to a relatively high concentration of brevetoxin-3 ( similar to 400 mu g/m super(3)) by nose-only inhalation for a 2-h period. Further, a subset of these mice received a second exposure a day later that lasted for an additional 4 h. Mice exposed only once for 2 h did not exhibit any notable cochlear effects. Similarly, mice exposed two times, for a cumulative dose of 6 h, exhibited essentially no change in DPOAE levels. JF - Journal of Comparative Physiology, A AU - Benson, J M AU - Stagner, B B AU - Martin, G K AU - Friedman, M AU - Durr, SE AU - Gomez, A AU - McDonald, J AU - Fleming, LE AU - Backer, L C AU - Baden, D G AU - Bourdelais, A AU - Naar, J AU - Lonsbury-Martin, B L AD - Department of Otolaryngology, University of Colorado Health Sciences Center, Denver, CO, USA, glen.martin2@med.va.gov Y1 - 2005/07// PY - 2005 DA - Jul 2005 SP - 619 EP - 626 VL - 191 IS - 7 SN - 0340-7594, 0340-7594 KW - brevetoxin 3 KW - brevetoxin-3 KW - dose-response effects KW - mice KW - Animal Behavior Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Y 25697:Mammals (excluding primates) KW - X 24172:Plants KW - N3 11016:Auditory and vestibular systems (including echolocation) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17661155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Comparative+Physiology%2C+A&rft.atitle=Cochlear+function+in+mice+following+inhalation+of+brevetoxin-3&rft.au=Benson%2C+J+M%3BStagner%2C+B+B%3BMartin%2C+G+K%3BFriedman%2C+M%3BDurr%2C+SE%3BGomez%2C+A%3BMcDonald%2C+J%3BFleming%2C+LE%3BBacker%2C+L+C%3BBaden%2C+D+G%3BBourdelais%2C+A%3BNaar%2C+J%3BLonsbury-Martin%2C+B+L&rft.aulast=Benson&rft.aufirst=J&rft.date=2005-07-01&rft.volume=191&rft.issue=7&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Journal+of+Comparative+Physiology%2C+A&rft.issn=03407594&rft_id=info:doi/10.1007%2Fs00359-005-0613-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-12-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1007/s00359-005-0613-0 ER - TY - CPAPER T1 - Optimizing Informatics Support for Collaborative Care: Examples from Veterans Administration Smoking and Depression Treatment Programs T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39724447; 3959284 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Chaney, Edmund AU - Bonner, Laura AU - Vivell, Susan AU - Austin, Colletta AU - Sherman, Scott Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Mental disorders KW - Depression KW - Smoking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39724447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Optimizing+Informatics+Support+for+Collaborative+Care%3A+Examples+from+Veterans+Administration+Smoking+and+Depression+Treatment+Programs&rft.au=Chaney%2C+Edmund%3BBonner%2C+Laura%3BVivell%2C+Susan%3BAustin%2C+Colletta%3BSherman%2C+Scott&rft.aulast=Chaney&rft.aufirst=Edmund&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hospital Market Effects on Uptake and Utilization of Innovative Healthcare Technologies: 1983-2001 T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39686570; 3958772 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Groeneveld, Peter AU - Kruse, Gregory AU - Brookstein, Ellen K AU - Zhu, Jingsan AU - Chen, Zhen AU - Volpp, Kevin G M Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Hospitals KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39686570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Hospital+Market+Effects+on+Uptake+and+Utilization+of+Innovative+Healthcare+Technologies%3A+1983-2001&rft.au=Groeneveld%2C+Peter%3BKruse%2C+Gregory%3BBrookstein%2C+Ellen+K%3BZhu%2C+Jingsan%3BChen%2C+Zhen%3BVolpp%2C+Kevin+G+M&rft.aulast=Groeneveld&rft.aufirst=Peter&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Telemedicine Intervention to Improve Depression Care in Rural CBOCs T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39685477; 3958380 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Fortney, John AU - Pyne, Jeff M AU - Edlund, Mark J AU - Robinson, Dean E AU - Mittal, Dinesh AU - Henderson, Kathy L Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Mental disorders KW - Depression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39685477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Telemedicine+Intervention+to+Improve+Depression+Care+in+Rural+CBOCs&rft.au=Fortney%2C+John%3BPyne%2C+Jeff+M%3BEdlund%2C+Mark+J%3BRobinson%2C+Dean+E%3BMittal%2C+Dinesh%3BHenderson%2C+Kathy+L&rft.aulast=Fortney&rft.aufirst=John&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Qualitative Observations to Inform a Quantitative Survey Design in Human Factors Research T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39684798; 3958763 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Lulejian, Armine AU - Patterson, Emily AU - Saleem, Jason AU - Militello, Laura AU - Asch, Steven Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Human factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39684798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Using+Qualitative+Observations+to+Inform+a+Quantitative+Survey+Design+in+Human+Factors+Research&rft.au=Lulejian%2C+Armine%3BPatterson%2C+Emily%3BSaleem%2C+Jason%3BMilitello%2C+Laura%3BAsch%2C+Steven&rft.aulast=Lulejian&rft.aufirst=Armine&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nursing Factors and Surgical Outcomes in VHA T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39683602; 3959120 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Lowy, Elliott AU - Anne, E AU - Sharp, Nancy AU - Greiner, Gwendolyn AU - Li, Yu Fang Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Nursing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39683602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Nursing+Factors+and+Surgical+Outcomes+in+VHA&rft.au=Lowy%2C+Elliott%3BAnne%2C+E%3BSharp%2C+Nancy%3BGreiner%2C+Gwendolyn%3BLi%2C+Yu+Fang&rft.aulast=Lowy&rft.aufirst=Elliott&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Relationship of Hospital Organizational Culture to Patient Safety Indicators T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39683291; 3959139 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Rivard, Peter AU - Christiansen, Cindy L AU - Zhao, Shibei AU - Loveland, Susan A AU - Rosen, Amy K Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Hospitals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39683291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=The+Relationship+of+Hospital+Organizational+Culture+to+Patient+Safety+Indicators&rft.au=Rivard%2C+Peter%3BChristiansen%2C+Cindy+L%3BZhao%2C+Shibei%3BLoveland%2C+Susan+A%3BRosen%2C+Amy+K&rft.aulast=Rivard&rft.aufirst=Peter&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Weighted versus Dichotomous Thresholds for Diabetes Performance Measurement in Veterans Health Administration (VHA) Facilities T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39683043; 3959077 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Aron, David AU - Pogach, Leonard M AU - Rajan, Mangala Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39683043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Comparison+of+Weighted+versus+Dichotomous+Thresholds+for+Diabetes+Performance+Measurement+in+Veterans+Health+Administration+%28VHA%29+Facilities&rft.au=Aron%2C+David%3BPogach%2C+Leonard+M%3BRajan%2C+Mangala&rft.aulast=Aron&rft.aufirst=David&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Civility among Healthcare Employees: The Impact on Patients T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39677195; 3958876 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Meterko, Mark AU - Mohr, David AU - Charns, Martin AU - Warren, Nicholas AU - Hodgson, Michael Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Personnel KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39677195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Civility+among+Healthcare+Employees%3A+The+Impact+on+Patients&rft.au=Meterko%2C+Mark%3BMohr%2C+David%3BCharns%2C+Martin%3BWarren%2C+Nicholas%3BHodgson%2C+Michael&rft.aulast=Meterko&rft.aufirst=Mark&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nursing Factors and Patient Outcomes in VHA T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39676587; 3959143 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Sales, Anne AU - Sharp, Nancy AU - Greiner, Gwendolyn AU - Li, Yu-Fang AU - Lowy, Elliott Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Nursing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39676587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Nursing+Factors+and+Patient+Outcomes+in+VHA&rft.au=Sales%2C+Anne%3BSharp%2C+Nancy%3BGreiner%2C+Gwendolyn%3BLi%2C+Yu-Fang%3BLowy%2C+Elliott&rft.aulast=Sales&rft.aufirst=Anne&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Quality Olympics: A System-Wide Approach to Improving Diabetes Care T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39676071; 3959078 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Aron, David AU - Ober, Scott AU - Caron, Aleece AU - Davidson, Michelle AU - Aron, David C Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39676071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=The+Quality+Olympics%3A+A+System-Wide+Approach+to+Improving+Diabetes+Care&rft.au=Aron%2C+David%3BOber%2C+Scott%3BCaron%2C+Aleece%3BDavidson%2C+Michelle%3BAron%2C+David+C&rft.aulast=Aron&rft.aufirst=David&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enrollment in Medicare HMO by Elderly Women Veterans T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39663743; 3958739 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Wei, Iris AU - John, Dolly AU - Davila, Jessica AU - Byrne, Margaret AU - Petersen, Laura AU - Osemene, Nora AU - Sundaravaradan, Raji AU - Morgan, Robert Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Elderly KW - Geriatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39663743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Enrollment+in+Medicare+HMO+by+Elderly+Women+Veterans&rft.au=Wei%2C+Iris%3BJohn%2C+Dolly%3BDavila%2C+Jessica%3BByrne%2C+Margaret%3BPetersen%2C+Laura%3BOsemene%2C+Nora%3BSundaravaradan%2C+Raji%3BMorgan%2C+Robert&rft.aulast=Wei&rft.aufirst=Iris&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Searching for Womens Health Centers: Yield of Internet vs. Traditional Telephone Contacts for Identifying Research Sites T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39663565; 3958718 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Bayliss, Nichole AU - Bean-Mayberry, Bevanne AU - Yano, Elizabeth M AU - Navratil, Judith AU - Weisman, Carol S AU - Scholle, Sarah Hudson Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Internet KW - Telephone systems KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39663565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Searching+for+Womens+Health+Centers%3A+Yield+of+Internet+vs.+Traditional+Telephone+Contacts+for+Identifying+Research+Sites&rft.au=Bayliss%2C+Nichole%3BBean-Mayberry%2C+Bevanne%3BYano%2C+Elizabeth+M%3BNavratil%2C+Judith%3BWeisman%2C+Carol+S%3BScholle%2C+Sarah+Hudson&rft.aulast=Bayliss&rft.aufirst=Nichole&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Evaluation of Contextual Factors in Breast and Cervical Cancer Screening T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39662959; 3958591 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Tomolo, Anne AU - Litaker, David AU - Aron, David Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Cervical cancer KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39662959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=An+Evaluation+of+Contextual+Factors+in+Breast+and+Cervical+Cancer+Screening&rft.au=Tomolo%2C+Anne%3BLitaker%2C+David%3BAron%2C+David&rft.aulast=Tomolo&rft.aufirst=Anne&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Medicare+Choice Enrollment and Plan Benefits Among Black, Hispanic and White Medicare Enrolled VA-Using Veterans in CY2000 T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39662882; 3958594 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - John, Dolly A AU - Sundaravaradan, Raji AU - Davila, Jessica AU - Wei, Iris I AU - Byrne, Margaret AU - Petersen, Laura AU - Paterniti, Debora A AU - Osemene, Nora AU - Morgan, Robert O Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Highways KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39662882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Medicare%2BChoice+Enrollment+and+Plan+Benefits+Among+Black%2C+Hispanic+and+White+Medicare+Enrolled+VA-Using+Veterans+in+CY2000&rft.au=John%2C+Dolly+A%3BSundaravaradan%2C+Raji%3BDavila%2C+Jessica%3BWei%2C+Iris+I%3BByrne%2C+Margaret%3BPetersen%2C+Laura%3BPaterniti%2C+Debora+A%3BOsemene%2C+Nora%3BMorgan%2C+Robert+O&rft.aulast=John&rft.aufirst=Dolly&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Timing of Surgical and Adjuvant Therapy for Colorectal Cancer T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39659117; 3958565 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Hynes, Denise AU - Perrin, Ruth A AU - Zhang, Qiuying AU - Koelling, Kristin AU - Sohn, Min-Woong Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Adjuvants KW - Therapy KW - Colorectal cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39659117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Timing+of+Surgical+and+Adjuvant+Therapy+for+Colorectal+Cancer&rft.au=Hynes%2C+Denise%3BPerrin%2C+Ruth+A%3BZhang%2C+Qiuying%3BKoelling%2C+Kristin%3BSohn%2C+Min-Woong&rft.aulast=Hynes&rft.aufirst=Denise&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nurses in VHA Hospitals: Results from the Nurse Staffing and Patient Outcomes in VA Nursing Staff Survey T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39654484; 3959232 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Sharp, Nancy AU - Sales, Anne E AU - Greiner, Gwendolyn T AU - Li, Yu-Fang AU - Mitchell, Pamela AU - Sochalski, Julie Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Nursing KW - Medical personnel KW - Hospitals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39654484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Nurses+in+VHA+Hospitals%3A+Results+from+the+Nurse+Staffing+and+Patient+Outcomes+in+VA+Nursing+Staff+Survey&rft.au=Sharp%2C+Nancy%3BSales%2C+Anne+E%3BGreiner%2C+Gwendolyn+T%3BLi%2C+Yu-Fang%3BMitchell%2C+Pamela%3BSochalski%2C+Julie&rft.aulast=Sharp&rft.aufirst=Nancy&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Provider-Friendly Screening Tool to Identify Patients who Lack Physician Trust T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39653407; 3958671 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Kuykendall, David AU - Kallen, Michael Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39653407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=A+Provider-Friendly+Screening+Tool+to+Identify+Patients+who+Lack+Physician+Trust&rft.au=Kuykendall%2C+David%3BKallen%2C+Michael&rft.aulast=Kuykendall&rft.aufirst=David&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Primary Care Physician Characteristics and Involvement in a Program to Improve Outpatient Clinic Operations T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39653100; 3959373 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Mohr, David AU - Lukas, Carol VanDeusen AU - Meterko, Mark AU - Seibert, Marjorie Nealon Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Financial management KW - Policies KW - Public access KW - Public health KW - Drugs KW - Insurance KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39653100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Primary+Care+Physician+Characteristics+and+Involvement+in+a+Program+to+Improve+Outpatient+Clinic+Operations&rft.au=Mohr%2C+David%3BLukas%2C+Carol+VanDeusen%3BMeterko%2C+Mark%3BSeibert%2C+Marjorie+Nealon&rft.aulast=Mohr&rft.aufirst=David&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Women Veterans Satisfaction with VA Hospitalization T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39651998; 3958724 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Cherrie, Carron AU - Schwartz, Skai AU - Mathias, Leigh AU - Mikelonis, Margaret AU - Lawrie, Toni Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Financial management KW - Policies KW - Public access KW - Public health KW - Drugs KW - Insurance KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39651998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Women+Veterans+Satisfaction+with+VA+Hospitalization&rft.au=Cherrie%2C+Carron%3BSchwartz%2C+Skai%3BMathias%2C+Leigh%3BMikelonis%2C+Margaret%3BLawrie%2C+Toni&rft.aulast=Cherrie&rft.aufirst=Carron&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Educational Attainment and Cancer Mortality, 1959 - 2001: Patterns, Trends, and Pathways T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39651884; 3958697 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Tarlov, Elizabeth AU - Kaestner, Robert AU - Warnecke, Richard Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Mortality KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39651884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Educational+Attainment+and+Cancer+Mortality%2C+1959+-+2001%3A+Patterns%2C+Trends%2C+and+Pathways&rft.au=Tarlov%2C+Elizabeth%3BKaestner%2C+Robert%3BWarnecke%2C+Richard&rft.aulast=Tarlov&rft.aufirst=Elizabeth&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Physician Attitudes Toward Pay-For-Performance Programs: Development and Validation of a Measurement Instrument T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39650861; 3959125 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Meterko, Mark AU - Young, Gary J AU - White, Bert AU - Burgess, James F AU - Berlowitz, Dan AU - Guldin, Matthew R Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Financial management KW - Policies KW - Public access KW - Public health KW - Drugs KW - Insurance KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39650861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Physician+Attitudes+Toward+Pay-For-Performance+Programs%3A+Development+and+Validation+of+a+Measurement+Instrument&rft.au=Meterko%2C+Mark%3BYoung%2C+Gary+J%3BWhite%2C+Bert%3BBurgess%2C+James+F%3BBerlowitz%2C+Dan%3BGuldin%2C+Matthew+R&rft.aulast=Meterko&rft.aufirst=Mark&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Depression and At-Risk Alcohol use Outcomes for Older Primary Care Patients in Integrated Care and Enhanced Specialty Referral T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39647538; 3959296 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Krahn, Dean AU - Bartels, Steve AU - Coakley, Eugenie AU - Oslin, David AU - Chung, Henry AU - Levkoff, Sue Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Mental disorders KW - Depression KW - Alcohols KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39647538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Depression+and+At-Risk+Alcohol+use+Outcomes+for+Older+Primary+Care+Patients+in+Integrated+Care+and+Enhanced+Specialty+Referral&rft.au=Krahn%2C+Dean%3BBartels%2C+Steve%3BCoakley%2C+Eugenie%3BOslin%2C+David%3BChung%2C+Henry%3BLevkoff%2C+Sue&rft.aulast=Krahn&rft.aufirst=Dean&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Impact of VA Priority Score on use of Fecal Occult Blood Test in VA and Medicare Systems T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39642166; 3959459 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Schult, Tamara AU - Virnig, Beth AU - Kochevar, Laura AU - Nelson, Dave AU - Bershadsky, Boris Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Blood KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39642166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=The+Impact+of+VA+Priority+Score+on+use+of+Fecal+Occult+Blood+Test+in+VA+and+Medicare+Systems&rft.au=Schult%2C+Tamara%3BVirnig%2C+Beth%3BKochevar%2C+Laura%3BNelson%2C+Dave%3BBershadsky%2C+Boris&rft.aulast=Schult&rft.aufirst=Tamara&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Survey of Nursing Work Environment: A Confirmatory Factor Analysis of the Nursing Work Index-Revised T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39639956; 3959220 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Li, Yu-Fang AU - Sales, Anne AU - Sharp, Nancy AU - Greiner, Gwen AU - Lowy, Elliott Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Environmental factors KW - Nursing KW - Factor analysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39639956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Survey+of+Nursing+Work+Environment%3A+A+Confirmatory+Factor+Analysis+of+the+Nursing+Work+Index-Revised&rft.au=Li%2C+Yu-Fang%3BSales%2C+Anne%3BSharp%2C+Nancy%3BGreiner%2C+Gwen%3BLowy%2C+Elliott&rft.aulast=Li&rft.aufirst=Yu-Fang&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Management Support in Implementing Innovative Clinical Practices T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39612746; 3958878 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Lukas, Carol VanDeusen AU - Meterko, Mark AU - Mohr, David AU - Seibert, Marjorie Nealon Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Financial management KW - Policies KW - Public access KW - Public health KW - Drugs KW - Insurance KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=The+Role+of+Management+Support+in+Implementing+Innovative+Clinical+Practices&rft.au=Lukas%2C+Carol+VanDeusen%3BMeterko%2C+Mark%3BMohr%2C+David%3BSeibert%2C+Marjorie+Nealon&rft.aulast=Lukas&rft.aufirst=Carol&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Outcomes of the Assisted Living Pilot Program T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39612608; 3958845 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Hedrick, Susan AU - Guihan, Marylou AU - Chapko, Michael AU - Manheim, Larry AU - Sullivan, Jean AU - Tornatore, Jane Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Financial management KW - Policies KW - Public access KW - Public health KW - Drugs KW - Insurance KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Outcomes+of+the+Assisted+Living+Pilot+Program&rft.au=Hedrick%2C+Susan%3BGuihan%2C+Marylou%3BChapko%2C+Michael%3BManheim%2C+Larry%3BSullivan%2C+Jean%3BTornatore%2C+Jane&rft.aulast=Hedrick&rft.aufirst=Susan&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of a Medication Copayment Increase on Medication Acquisition in the VA T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39612386; 3958798 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Stroupe, Kevin AU - Smith, Bridget AU - Lee, Todd AU - Durazo-Arvizu, Ramon AU - Tarlov, Elizabeth AU - Cao, Lishan Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Financial management KW - Policies KW - Public access KW - Public health KW - Drugs KW - Insurance KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Impact+of+a+Medication+Copayment+Increase+on+Medication+Acquisition+in+the+VA&rft.au=Stroupe%2C+Kevin%3BSmith%2C+Bridget%3BLee%2C+Todd%3BDurazo-Arvizu%2C+Ramon%3BTarlov%2C+Elizabeth%3BCao%2C+Lishan&rft.aulast=Stroupe&rft.aufirst=Kevin&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Liver Health Initiative: Coordinating Hepatitis Prevention and Treatment Referral through a Substance use Disorders Clinic T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39604497; 3958397 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Hagedorn, Hildi AU - Willenbring, Mark AU - Dieperink, Eric AU - Ho, Samuel AU - Pexa, Nancy AU - Dingmann, Debra Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Prevention KW - Liver KW - Hepatitis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39604497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=The+Liver+Health+Initiative%3A+Coordinating+Hepatitis+Prevention+and+Treatment+Referral+through+a+Substance+use+Disorders+Clinic&rft.au=Hagedorn%2C+Hildi%3BWillenbring%2C+Mark%3BDieperink%2C+Eric%3BHo%2C+Samuel%3BPexa%2C+Nancy%3BDingmann%2C+Debra&rft.aulast=Hagedorn&rft.aufirst=Hildi&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Racial Differences in Attitudes toward Innovative Medical Technology T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39601658; 3958659 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Groeneveld, Peter AU - Sonnad, Seema S AU - Lee, Anee K AU - Asch, David A AU - Shea, Judy A Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Financial management KW - Policies KW - Public access KW - Public health KW - Drugs KW - Insurance KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39601658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Racial+Differences+in+Attitudes+toward+Innovative+Medical+Technology&rft.au=Groeneveld%2C+Peter%3BSonnad%2C+Seema+S%3BLee%2C+Anee+K%3BAsch%2C+David+A%3BShea%2C+Judy+A&rft.aulast=Groeneveld&rft.aufirst=Peter&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Influence of Organizational Culture on Physician and Nurse Resignation Rates T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39598198; 3959203 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Mohr, David AU - Meterko, Mark AU - Young, Gary AU - Charns, Martin Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Nursing KW - Medical personnel KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39598198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=The+Influence+of+Organizational+Culture+on+Physician+and+Nurse+Resignation+Rates&rft.au=Mohr%2C+David%3BMeterko%2C+Mark%3BYoung%2C+Gary%3BCharns%2C+Martin&rft.aulast=Mohr&rft.aufirst=David&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of a Patient-Centered Care Coordination/Home-Telehealth Disease Management Program for Veterans with Diabetes T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39568697; 3958492 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Chumbler, Neale AU - Vogel, W Bruce AU - Garel, Mischka AU - Qin, Haijing AU - Kobb, Rita AU - Ryan, Patricia Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39568697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Evaluation+of+a+Patient-Centered+Care+Coordination%2FHome-Telehealth+Disease+Management+Program+for+Veterans+with+Diabetes&rft.au=Chumbler%2C+Neale%3BVogel%2C+W+Bruce%3BGarel%2C+Mischka%3BQin%2C+Haijing%3BKobb%2C+Rita%3BRyan%2C+Patricia&rft.aulast=Chumbler&rft.aufirst=Neale&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Organizational Attributes Important in Leaders' Efforts to Transform Health Care T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39563070; 3958890 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Cramer, Irene E AU - Shwartz, Michael AU - Holmes, Sally K AU - Restuccia, Joseph AU - Cohen, Alan B AU - Lukas, Carol VanDeusen AU - Sullivan, Jenny AU - Meterko, Mark AU - Charns, Martin P Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39563070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Organizational+Attributes+Important+in+Leaders%27+Efforts+to+Transform+Health+Care&rft.au=Cramer%2C+Irene+E%3BShwartz%2C+Michael%3BHolmes%2C+Sally+K%3BRestuccia%2C+Joseph%3BCohen%2C+Alan+B%3BLukas%2C+Carol+VanDeusen%3BSullivan%2C+Jenny%3BMeterko%2C+Mark%3BCharns%2C+Martin+P&rft.aulast=Cramer&rft.aufirst=Irene&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. AN - 67934941; 15955935 AB - To determine the relative tolerability and efficacy of two newer antiepileptic drugs, lamotrigine (LTG) and gabapentin (GBP), as compared to carbamazepine (CBZ) in older patients with epilepsy. This was an 18-center, randomized, double-blind, double dummy, parallel study of 593 elderly subjects with newly diagnosed seizures. Patients were randomly assigned to one of three treatment groups: GBP 1,500 mg/day, LTG 150 mg/day, CBZ 600 mg/day. The primary outcome measure was retention in trial for 12 months. Mean age was 72 years. The most common etiology was cerebral infarction. Patients had multiple medical conditions and took an average of seven comedications. Mean plasma levels at 6 weeks were as follows: GBP 8.67 +/- 4.83 microg/mL, LTG 2.87 +/- 1.60 microg/mL, CBZ 6.79 +/- 2.92 microg/mL. They remained stable throughout the trial. Early terminations: LTG 44.2%, GBP 51%, CBZ 64.5% (p = 0.0002). Significant paired comparisons: LTG vs CBZ: p < 0.0001; GBP vs CBZ: p = 0.008. Terminations for adverse events: LTG 12.1%, GBP 21.6%, CBZ 31% (p = 0.001). Significant paired comparisons: LTG vs CBZ: p < 0.0001; LTG vs GBP: p = 0.015. There were no significant differences in seizure free rate at 12 months. The main limiting factor in patient retention was adverse drug reactions. Patients taking lamotrigine (LTG) or gabapentin (GBP) did better than those taking carbamazepine. Seizure control was similar among groups. LTG and GBP should be considered as initial therapy for older patients with newly diagnosed seizures. JF - Neurology AU - Rowan, A J AU - Ramsay, R E AU - Collins, J F AU - Pryor, F AU - Boardman, K D AU - Uthman, B M AU - Spitz, M AU - Frederick, T AU - Towne, A AU - Carter, G S AU - Marks, W AU - Felicetta, J AU - Tomyanovich, M L AU - VA Cooperative Study 428 Group AD - VA Medical Center, Bronx, NY 10468, USA. aj.rowan@med.va.gov ; VA Cooperative Study 428 Group Y1 - 2005/06/14/ PY - 2005 DA - 2005 Jun 14 SP - 1868 EP - 1873 VL - 64 IS - 11 KW - Amines KW - 0 KW - Anticonvulsants KW - Cyclohexanecarboxylic Acids KW - Triazines KW - Carbamazepine KW - 33CM23913M KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - gabapentin KW - 6CW7F3G59X KW - lamotrigine KW - U3H27498KS KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Patient Compliance -- statistics & numerical data KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Humans KW - Treatment Outcome KW - Aged KW - Patient Selection KW - Hospitals, Veterans -- statistics & numerical data KW - United States Department of Veterans Affairs -- statistics & numerical data KW - Cerebral Infarction -- complications KW - gamma-Aminobutyric Acid -- blood KW - Amines -- administration & dosage KW - Anticonvulsants -- adverse effects KW - Anticonvulsants -- administration & dosage KW - Cyclohexanecarboxylic Acids -- administration & dosage KW - Epilepsy -- drug therapy KW - gamma-Aminobutyric Acid -- adverse effects KW - gamma-Aminobutyric Acid -- administration & dosage KW - Anticonvulsants -- blood KW - Triazines -- blood KW - Aging -- physiology KW - Amines -- blood KW - Carbamazepine -- adverse effects KW - Cyclohexanecarboxylic Acids -- adverse effects KW - Carbamazepine -- blood KW - Carbamazepine -- administration & dosage KW - Cyclohexanecarboxylic Acids -- blood KW - Triazines -- adverse effects KW - Triazines -- administration & dosage KW - Epilepsy -- etiology KW - Epilepsy -- epidemiology KW - Amines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67934941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=New+onset+geriatric+epilepsy%3A+a+randomized+study+of+gabapentin%2C+lamotrigine%2C+and+carbamazepine.&rft.au=Rowan%2C+A+J%3BRamsay%2C+R+E%3BCollins%2C+J+F%3BPryor%2C+F%3BBoardman%2C+K+D%3BUthman%2C+B+M%3BSpitz%2C+M%3BFrederick%2C+T%3BTowne%2C+A%3BCarter%2C+G+S%3BMarks%2C+W%3BFelicetta%2C+J%3BTomyanovich%2C+M+L%3BVA+Cooperative+Study+428+Group&rft.aulast=Rowan&rft.aufirst=A&rft.date=2005-06-14&rft.volume=64&rft.issue=11&rft.spage=1868&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=1526-632X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-27 N1 - Date created - 2005-06-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: ACP J Club. 2006 Jan-Feb;144(1):6 [16388556] Neurology. 2005 Jun 14;64(11):1834-5 [15955930] Epilepsy Curr. 2006 Jan-Feb;6(1):27-9 [16477322] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gulf War veterans' health: medical evaluation of a U.S. cohort. AN - 67910083; 15941694 AB - United States military personnel reported various symptoms after deployment to the Persian Gulf during the 1991 Gulf War. However, the symptoms' long-term prevalence and association with deployment remain controversial. To assess and compare the prevalence of selected medical conditions in a national cohort of deployed and nondeployed Gulf War veterans who were evaluated by direct medical and teledermatologic examinations. A cross-sectional prevalence study performed 10 years after the 1991 Gulf War. Veterans were examined at 1 of 16 Veterans Affairs medical centers. Deployed (n = 1061) and nondeployed (n = 1128) veterans of the 1991 Gulf War. Primary outcome measures included fibromyalgia, the chronic fatigue syndrome, dermatologic conditions, dyspepsia, physical health-related quality of life (Short Form-36 [SF-36]), hypertension, obstructive lung disease, arthralgias, and peripheral neuropathy. Of 12 conditions, only 4 conditions were more prevalent among deployed than nondeployed veterans: fibromyalgia (deployed, 2.0%; nondeployed, 1.2%; odds ratio, 2.32 [95% CI, 1.02 to 5.27]); the chronic fatigue syndrome (deployed, 1.6%; nondeployed 0.1%; odds ratio, 40.6 [CI, 10.2 to 161]); dermatologic conditions (deployed, 34.6%; nondeployed, 26.8%; odds ratio, 1.38 [CI, 1.06 to 1.80]), and dyspepsia (deployed, 9.1%; nondeployed, 6.0%; odds ratio, 1.87 [CI, 1.16 to 2.99]). The mean physical component summary score of the SF-36 for deployed and nondeployed veterans was 49.3 and 50.8, respectively. Relatively low participation rates introduce potential participation bias, and deployment-related illnesses that resolved before the research examination could not, by design, be detected. Ten years after the Gulf War, the physical health of deployed and nondeployed veterans is similar. However, Gulf War deployment is associated with an increased risk for fibromyalgia, the chronic fatigue syndrome, skin conditions, dyspepsia, and a clinically insignificant decrease in the SF-36 physical component score. JF - Annals of internal medicine AU - Eisen, Seth A AU - Kang, Han K AU - Murphy, Frances M AU - Blanchard, Melvin S AU - Reda, Domenic J AU - Henderson, William G AU - Toomey, Rosemary AU - Jackson, Leila W AU - Alpern, Renee AU - Parks, Becky J AU - Klimas, Nancy AU - Hall, Coleen AU - Pak, Hon S AU - Hunter, Joyce AU - Karlinsky, Joel AU - Battistone, Michael J AU - Lyons, Michael J AU - Gulf War Study Participating Investigators AD - Veterans Affairs Medical Center, Washington University School of Medicine, St. Louis, Missouri 63106, USA. seth.eisen@med.va.gov ; Gulf War Study Participating Investigators Y1 - 2005/06/07/ PY - 2005 DA - 2005 Jun 07 SP - 881 EP - 890 VL - 142 IS - 11 KW - Abridged Index Medicus KW - Index Medicus KW - Fibromyalgia -- epidemiology KW - Gulf War KW - Humans KW - Quality of Life KW - Skin Diseases -- epidemiology KW - Warfare KW - Veterans KW - Peripheral Nervous System Diseases -- epidemiology KW - Cross-Sectional Studies KW - Adult KW - Bias (Epidemiology) KW - Dyspepsia -- epidemiology KW - United States -- epidemiology KW - Fatigue Syndrome, Chronic -- epidemiology KW - Female KW - Male KW - Prevalence KW - Persian Gulf Syndrome -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67910083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Gulf+War+veterans%27+health%3A+medical+evaluation+of+a+U.S.+cohort.&rft.au=Eisen%2C+Seth+A%3BKang%2C+Han+K%3BMurphy%2C+Frances+M%3BBlanchard%2C+Melvin+S%3BReda%2C+Domenic+J%3BHenderson%2C+William+G%3BToomey%2C+Rosemary%3BJackson%2C+Leila+W%3BAlpern%2C+Renee%3BParks%2C+Becky+J%3BKlimas%2C+Nancy%3BHall%2C+Coleen%3BPak%2C+Hon+S%3BHunter%2C+Joyce%3BKarlinsky%2C+Joel%3BBattistone%2C+Michael+J%3BLyons%2C+Michael+J%3BGulf+War+Study+Participating+Investigators&rft.aulast=Eisen&rft.aufirst=Seth&rft.date=2005-06-07&rft.volume=142&rft.issue=11&rft.spage=881&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-17 N1 - Date created - 2005-06-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Intern Med. 2005 Jun 7;142(11):938-9 [15941702] Summary For Patients In: Ann Intern Med. 2005 Jun 7;142(11):I22 [15941690] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recognition of Hearing Aid Orientation Content by First-Time Users AN - 85680226; 200701865 AB - Purpose: To examine how well hearing aid orientation (HAO) content is remembered immediately & 1 month after the HAO, & whether the ability to remember this information differs as a function of the audiologist providing the information, patient's age, degree of hearing loss, & prior knowledge of hearing aids. Methods: A convenience sample of 100 older adults completed a multiple-choice test of hearing aid knowledge immediately following the HAO & 1 month later. Covariate & regression analyses were Results: On average, participants recognized 74% of the information immediately following HAO & 78% at 1 month. Hearing loss was associated with declining recognition for hearing aid use & care information immediately following HAO, whereas prior knowledge was associated with successful recognition. Participants who recognized more HAO content immediately also remembered more at 1 month. A difference in recognition of hearing aid information based on audiologist was suggested immediately following HAO, but there were no differences at 1 month. Ability to recognize HAO content was not related to age of participants. Conclusions: On average, participants recognized approximately 75% of the HAO content, which is encouraging from a clinical standpoint, providing support for the efficacy of the HAO & the time audiologists spend in completing it. Moreover, recognition of HAO content improved when tested at 1 month, suggesting audiologists may expect their patients to be aware of a majority of hearing aid use & care information following the hearing aid trial period. Tables, Appendixes, References. Adapted from the source document JF - American Journal of Audiology AU - Reese, Judith L AU - Hnath-Chisolm, Theresa AD - VA Hospital, Tampa, FL judith.reese2@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 94 EP - 104 VL - 14 IS - 1 SN - 1059-0889, 1059-0889 KW - Hearing Therapy (31580) KW - Patients (62950) KW - Audiology (05550) KW - Information Content (35890) KW - Hearing Aids (31250) KW - Practitioner Patient Relationship (66830) KW - article KW - 6811: special education; hearing therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85680226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Audiology&rft.atitle=Recognition+of+Hearing+Aid+Orientation+Content+by+First-Time+Users&rft.au=Reese%2C+Judith+L%3BHnath-Chisolm%2C+Theresa&rft.aulast=Reese&rft.aufirst=Judith&rft.date=2005-06-01&rft.volume=14&rft.issue=1&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Audiology&rft.issn=10590889&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2007-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJALFZ N1 - SubjectsTermNotLitGenreText - Hearing Aids (31250); Information Content (35890); Hearing Therapy (31580); Audiology (05550); Practitioner Patient Relationship (66830); Patients (62950) ER - TY - JOUR T1 - Clinical Guide for Audiologic Tinnitus Management II: Treatment AN - 85662019; 200701861 AB - Purpose: This article is the second of 2 that address the need for basic procedures that can be used commonly by audiologists to manage patients with clinically significant tinnitus, as well as hyperacusis. The method described is termed audiologic tinnitus management (ATM). Method: ATM was developed specifically for use by audiologists. Although certain procedural components were adapted from the methods of tinnitus masking & tinnitus retraining therapy, ATM is uniquely & specifically defined. A detailed description of the ATM assessment procedures is provided in the companion article (J. A. Henry, T. L. Zaugg, & M. A. Schechter, 2005). The present article describes a specific clinical protocol for providing treatment with ATM. Results: The treatment method described for ATM includes structured informational counseling & an individualized program of sound enhancement that can include the use of hearing aids, ear-level noise generators, combination instruments (noise generator & hearing aid combined), personal listening devices (wearable CD, tape, & MP3 players), & augmentative sound devices (e.g., tabletop sound generators). Ongoing treatment appointments involve primarily the structured counseling, evaluation, & adjustment of the use of sound devices, & assessment of treatment outcomes. The informational counseling protocol & an interview form for determining treatment outcomes are each described in step-by-step detail for direct clinical application. Conclusion: This article can serve as a practical clinical guide for audiologists to provide treatment for tinnitus in a uniform manner. Appendixes, References. Adapted from the source document JF - American Journal of Audiology AU - Henry, James A AU - Zaugg, Tara L AU - Schechter, Martin A AD - VA Medical Center, Portland, OR james.henry@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 49 EP - 70 VL - 14 IS - 1 SN - 1059-0889, 1059-0889 KW - Hearing Therapy (31580) KW - Hearing Improvement (31550) KW - Audiology (05550) KW - Hearing Disorders (31450) KW - Communication Aids (13620) KW - article KW - 6811: special education; hearing therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85662019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Audiology&rft.atitle=Clinical+Guide+for+Audiologic+Tinnitus+Management+II%3A+Treatment&rft.au=Henry%2C+James+A%3BZaugg%2C+Tara+L%3BSchechter%2C+Martin+A&rft.aulast=Henry&rft.aufirst=James&rft.date=2005-06-01&rft.volume=14&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Audiology&rft.issn=10590889&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2007-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJALFZ N1 - SubjectsTermNotLitGenreText - Hearing Disorders (31450); Hearing Therapy (31580); Audiology (05550); Communication Aids (13620); Hearing Improvement (31550) ER - TY - JOUR T1 - Clinical guide for audiologic tinnitus management I: Assessment. AN - 85392032; pmid-16180968 AB - This article is the first of 2 that present basic guidelines for audiologists to provide clinical management of tinnitus. The method, termed audiologic tinnitus management (ATM), was developed to incorporate management strategies that can be implemented most efficiently by audiologists.Development of ATM has been drawn from the clinical and research experience of the authors and numerous audiologists. Certain elements of ATM are adapted from the methods of tinnitus masking and tinnitus retraining therapy. Procedures are described in the present article for performing the intake assessment, while the companion article (J. A. Henry, T. L. Zaugg, & M. A. Schechter, 2005) describes treatment methodology.Development of ATM has resulted in defined procedures to conduct a basic tinnitus assessment that includes written questionnaires, an intake interview, audiologic evaluation, and a psychoacoustic assessment of tinnitus perceptual characteristics. If patients report a sound tolerance problem (hyperacusis), loudness discomfort levels are measured at audiometric frequencies. There are special procedures for selecting hearing aids, ear-level noise generators, combination devices (noise generator and hearing aid combined), and personal listening devices (i.e., portable radios and tape, CD, and MP3 players).This article explains each of these assessment components in detail. Adoption of the ATM assessment protocol by audiologists can contribute to the establishment of uniform procedures for the clinical management of tinnitus patients. JF - American journal of audiology AU - Henry, James A AU - Zaugg, Tara L AU - Schechter, Martin A AD - VA Medical Center, Portland, OR 97207, USA. james.henry@med.va.gov Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 21 EP - 48 VL - 14 IS - 1 SN - 1059-0889, 1059-0889 KW - Index Medicus KW - National Library of Medicine KW - Audiology: education KW - Audiometry, Pure-Tone KW - Auditory Threshold KW - Habituation, Psychophysiologic KW - Hearing Aids KW - Humans KW - Hyperacusis: complications KW - Otoscopy KW - Perceptual Masking KW - *Practice Guidelines as Topic KW - Psychoacoustics KW - Questionnaires KW - Referral and Consultation KW - Tinnitus: complications KW - *Tinnitus: diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85392032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+audiology&rft.atitle=Clinical+guide+for+audiologic+tinnitus+management+I%3A+Assessment.&rft.au=Henry%2C+James+A%3BZaugg%2C+Tara+L%3BSchechter%2C+Martin+A&rft.aulast=Henry&rft.aufirst=James&rft.date=2005-06-01&rft.volume=14&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=American+journal+of+audiology&rft.issn=10590889&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The 500 Hz masking-level difference and word recognition in multitalker babble for 40- to 89-year-old listeners with symmetrical sensorineural hearing loss. AN - 85387686; pmid-16178408 AB - The purpose of this study was to determine if performances on a 500 Hz MLD task and a word-recognition task in multitalker babble covaried or varied independently for listeners with normal hearing and for listeners with hearing loss. Young listeners with normal hearing (n = 25) and older listeners (25 per decade from 40-80 years, n = 125) with sensorineural hearing loss were studied. Thresholds at 500 and 1000 Hz were < or = 30 dB HL and < or = 40 dB HL, respectively, with thresholds above 1000 Hz < 100 dB HL. There was no systematic relationship between the 500 Hz MLD and word-recognition performance in multitalker babble. Higher SoNo and SpiNo thresholds were observed for the older listeners, but the MLDs were the same for all groups. Word recognition in babble in terms of signal-to-babble ratio was on average 6.5 (40- to 49-year-old group) to 10.8 dB (80- to 89-year-old group) poorer for the older listeners with hearing loss. Neither pure-tone thresholds nor word-recognition abilities in quiet accurately predicted word-recognition performance in multitalker babble. JF - Journal of the American Academy of Audiology AU - Wilson, Richard H AU - Weakley, Deborah G AD - James H. Quillen VA Medical Center, Mountain Home, Tennessee 37684, USA. RICHARD.WILSON2@MED.VA.GOV Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 367 EP - 382 VL - 16 IS - 6 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Acoustic Stimulation: instrumentation KW - Adult KW - Aged KW - Aged, 80 and over KW - Audiometry, Pure-Tone: instrumentation KW - Auditory Threshold: physiology KW - Differential Threshold: physiology KW - Equipment Design KW - *Hearing Loss, Sensorineural: diagnosis KW - *Hearing Loss, Sensorineural: physiopathology KW - Humans KW - Middle Aged KW - Perceptual Masking: physiology KW - *Recognition (Psychology) KW - *Speech Perception KW - *Verbal Behavior KW - *Vocabulary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85387686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=The+500+Hz+masking-level+difference+and+word+recognition+in+multitalker+babble+for+40-+to+89-year-old+listeners+with+symmetrical+sensorineural+hearing+loss.&rft.au=Wilson%2C+Richard+H%3BWeakley%2C+Deborah+G&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2005-06-01&rft.volume=16&rft.issue=6&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: J Am Acad Audiol. 2005 Jun;16(6):332[16178404] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - A qualitative analysis of inaccurate responses on the Hooper Visual Organization Test. AN - 85385729; pmid-16060429 AB - The present study investigated the types of inaccurate responses, i.e., Don't Know, Semantic, Visual (nonlinguistic), Phonological, Circumlocutory, and Perseverative, made on the Hooper Visual Organization Test by a heterogeneous sample of 68 brain-damaged and 63 substance abuse patients. The mean age of the brain-damaged and substance abuse groups were 46.0 (SD=13.5) and 43.7 (SD=12.9) yr., respectively. Analysis showed that the brain-damaged group made significantly more visual and perseverative responses than the substance abuse group. There was significantly more variance in the Visual responses than the Semantic responses for the brain-damaged group. The authors conclude that visuospatial ability is the primary factor for successful performance on this test. JF - Perceptual and motor skills AU - Lopez, Michael N AU - Lazar, Michael D AU - Imperio, Sherwin M AD - Department of Veterans Affairs Healthcare System, Long Beach, California 90822, USA. michael.lopez@med.va.gov Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 695 EP - 702 VL - 100 IS - 3 Pt 1 SN - 0031-5125, 0031-5125 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Agnosia: diagnosis KW - Agnosia: psychology KW - *Brain Damage, Chronic: diagnosis KW - Brain Damage, Chronic: psychology KW - *Cognition Disorders: diagnosis KW - Cognition Disorders: psychology KW - Humans KW - Middle Aged KW - *Neuropsychological Tests: statistics & numerical data KW - Perceptual Closure KW - Psychometrics KW - Reproducibility of Results KW - Semantics KW - Space Perception KW - *Substance-Related Disorders: diagnosis KW - Substance-Related Disorders: psychology KW - Verbal Behavior KW - *Visual Perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85385729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+motor+skills&rft.atitle=A+qualitative+analysis+of+inaccurate+responses+on+the+Hooper+Visual+Organization+Test.&rft.au=Lopez%2C+Michael+N%3BLazar%2C+Michael+D%3BImperio%2C+Sherwin+M&rft.aulast=Lopez&rft.aufirst=Michael&rft.date=2005-06-01&rft.volume=100&rft.issue=3+Pt+1&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+motor+skills&rft.issn=00315125&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Transient-evoked stimulus-frequency and distortion-product otoacoustic emissions in normal and impaired ears. AN - 85381296; pmid-16018483 AB - Transient-evoked stimulus-frequency otoacoustic emissions (SFOAEs), recorded using a nonlinear differential technique, and distortion-product otoacoustic emissions (DPOAEs) were measured in 17 normal-hearing and 10 hearing-impaired subjects using pairs of tone pips (pp), gated tones (gg), and for DPOAEs, continuous and gated tones (cg). Temporal envelopes of stimulus and OAE waveforms were obtained by narrow-band filtering at the stimulus or DP frequency. Mean SFOAE latencies in normal ears at 2.7 and 4.0 kHz decreased with increasing stimulus level and were larger at 4.0 kHz than latencies in impaired ears. Equivalent auditory filter bandwidths were calculated as a function of stimulus level from SFOAE latencies by assuming that cochlear transmission is minimum phase. DPOAE latencies varied less with level than SFOAE latencies. The ppDPOAEs often had two (or more) peaks separated in time with latencies consistent with model predictions for distortion and reflection components. Changes in ppDPOAE latency with level were sometimes explained by a shift in relative amplitudes of distortion and reflection components. The pp SFOAE SPL within the main spectral lobe of the pip stimulus was higher for normal ears in the higher-frequency half of the pip than the lower-frequency half, which is likely an effect of basilar membrane two-tone suppression. JF - The Journal of the Acoustical Society of America AU - Konrad-Martin, Dawn AU - Keefe, Douglas H AD - VA RR&D National Center For Rehabilitative Auditory Research, Portland VA Medical Center, Portland, Oregon 97239, USA. dawn.martin@med.va.gov Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 3799 EP - 3815 VL - 117 IS - 6 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Auditory Threshold: physiology KW - Female KW - *Hearing Disorders: diagnosis KW - Hearing Disorders: physiopathology KW - Humans KW - Loudness Perception: physiology KW - Male KW - *Otoacoustic Emissions, Spontaneous: physiology KW - Pitch Discrimination: physiology KW - Reaction Time: physiology KW - Reference Values KW - Sound Spectrography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85381296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Transient-evoked+stimulus-frequency+and+distortion-product+otoacoustic+emissions+in+normal+and+impaired+ears.&rft.au=Konrad-Martin%2C+Dawn%3BKeefe%2C+Douglas+H&rft.aulast=Konrad-Martin&rft.aufirst=Dawn&rft.date=2005-06-01&rft.volume=117&rft.issue=6&rft.spage=3799&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Innovation and Independence: Recent Advances in the Treatment of Paralysis AN - 85334411; llba-200513335 AB - Recent advances in neurobiology & computer technology have resulted in a number of innovations in the treatment of patients with paralysis. In this article, we provide an overview of two techniques under current investigation: (1) injection of chemicals to repair individual nerve fibers & (2) implantation of brain-machine interfaces to record, decode, & replicate individual neural signals. For readers who wish to learn more about respective human clinical trials, contact information is provided. 6 References. Adapted from the source document JF - Journal of Medical Speech-Language Pathology AU - Ross, Katherine B AD - Audiology & Speech Pathology Dept, Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ Katherine.ross3@med.va.gov Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - xxxix EP - xl VL - 13 IS - 2 SN - 1065-1438, 1065-1438 KW - *Nervous System Disorders (57100) KW - *Surgery (85900) KW - *Human Computer Communication (32790) KW - *Research Subjects (72970) KW - *Therapy (89500) KW - *Brain (09350) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85334411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Speech-Language+Pathology&rft.atitle=Innovation+and+Independence%3A+Recent+Advances+in+the+Treatment+of+Paralysis&rft.au=Ross%2C+Katherine+B&rft.aulast=Ross&rft.aufirst=Katherine&rft.date=2005-06-01&rft.volume=13&rft.issue=2&rft.spage=xxxix&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Speech-Language+Pathology&rft.issn=10651438&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2005-12-01 N1 - Last updated - 2014-06-17 N1 - CODEN - JSLPEP N1 - SubjectsTermNotLitGenreText - *Nervous System Disorders (57100); *Brain (09350); *Research Subjects (72970); *Human Computer Communication (32790); *Therapy (89500); *Surgery (85900) ER - TY - JOUR T1 - A placebo controlled, double-blind study of mecamylamine treatment for cocaine dependence in patients enrolled in an opiate replacement program. AN - 70159474; 16687365 AB - A placebo controlled, double-blind trial of mecamylamine treatment of cocaine dependence was performed in methadone or LAAM maintained subjects who met DSM-IV criteria for cocaine dependence. After an eight-week placebo run-in screening period, 35 subjects were randomly assigned to receive either mecamylamine (6 mg/day) or placebo transdermal patches for a 16-week treatment period. Outcome measures included quantitative urine benzoylecognine (BE) levels, self-report of cocaine use, cocaine craving, global impression scores, mood, retention, and safety. Mecamylamine was well tolerated, and study retention did not differ by treatment group. Evidence for cocaine use, based on urine BE levels and cocaine abstinence rates, did not differ by treatment group. Self reported cocaine use, cocaine craving, and global impression scores showed moderate improvement in both groups, with a significantly greater reduction in cocaine craving (p < 0.05) and self-rated severity of cocaine dependence (p < 0.05) in the placebo group. This pilot study does not support the effectiveness of mecamylamine for the treatment of cocaine dependence in methadone or LAAM maintained patients. JF - Substance abuse AU - Reid, Malcolm S AU - Angrist, Burt AU - Baker, Sherryl A AU - O'leary, Siobhan AU - Stone, Jennifer AU - Schwartz, Marion AU - Leiderman, Deborah AU - Montgomery, Ann AU - Elkashef, Ahmed AU - Majewska, Dorota AU - Robinson, James AU - Rotrosen, John AD - New York University School of Medicine, New York, NY 10010, USA. malcolm.reid@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 5 EP - 14 VL - 26 IS - 2 SN - 0889-7077, 0889-7077 KW - Narcotics KW - 0 KW - Nicotinic Antagonists KW - benzoylecgonine KW - 5353I8I6YS KW - Mecamylamine KW - 6EE945D3OK KW - Cocaine KW - I5Y540LHVR KW - Methadyl Acetate KW - L59OC40KWJ KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - New York City KW - Administration, Cutaneous KW - Cocaine -- analogs & derivatives KW - Double-Blind Method KW - Cocaine -- urine KW - Humans KW - Methadyl Acetate -- administration & dosage KW - Treatment Outcome KW - Narcotics -- administration & dosage KW - Methadone -- administration & dosage KW - Drug Evaluation, Preclinical KW - Male KW - Female KW - Nicotinic Antagonists -- administration & dosage KW - Mecamylamine -- administration & dosage KW - Urban Population KW - Nicotinic Antagonists -- adverse effects KW - Cocaine-Related Disorders -- rehabilitation KW - Mecamylamine -- adverse effects KW - Cocaine-Related Disorders -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70159474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse&rft.atitle=A+placebo+controlled%2C+double-blind+study+of+mecamylamine+treatment+for+cocaine+dependence+in+patients+enrolled+in+an+opiate+replacement+program.&rft.au=Reid%2C+Malcolm+S%3BAngrist%2C+Burt%3BBaker%2C+Sherryl+A%3BO%27leary%2C+Siobhan%3BStone%2C+Jennifer%3BSchwartz%2C+Marion%3BLeiderman%2C+Deborah%3BMontgomery%2C+Ann%3BElkashef%2C+Ahmed%3BMajewska%2C+Dorota%3BRobinson%2C+James%3BRotrosen%2C+John&rft.aulast=Reid&rft.aufirst=Malcolm&rft.date=2005-06-01&rft.volume=26&rft.issue=2&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Substance+abuse&rft.issn=08897077&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-17 N1 - Date created - 2006-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Deployment stressors, gender, and mental health outcomes among Gulf War I veterans. AN - 68784754; 16281224 AB - Findings indicate that war-zone exposure has negative implications for the postdeployment adjustment of veterans; however, most studies have relied on limited conceptualizations of war-zone exposure and focused on male samples. In this study, an array of deployment stressors that were content valid for both female and male Gulf War I military personnel was examined to elucidate gender differences in war-zone exposure and identify gender-based differential associations between stressors and mental health outcomes. While women and men were exposed to both mission-related and interpersonal stressors and both stressor categories were associated with mental health outcomes, women reported more interpersonal stressors and these stressors generally had a stronger impact on women's than on men's mental health. Exceptions are described, and implications are discussed. JF - Journal of traumatic stress AU - Vogt, Dawne S AU - Pless, Anica P AU - King, Lynda A AU - King, Daniel W AD - Women's Health Sciences Division, National Center for PTSD, VA Boston Healthcare System, Boston, Massachusetts 02130, USA. Dawne.Vogt@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 272 EP - 284 VL - 18 IS - 3 SN - 0894-9867, 0894-9867 KW - Index Medicus KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Regression Analysis KW - Sex Factors KW - Stress Disorders, Post-Traumatic -- psychology KW - Anxiety Disorders -- psychology KW - Depressive Disorder -- psychology KW - Humans KW - Interpersonal Relations KW - Sexual Harassment KW - Depressive Disorder -- epidemiology KW - Health Surveys KW - Social Support KW - Anxiety Disorders -- epidemiology KW - United States -- epidemiology KW - Female KW - Male KW - Stress, Psychological -- etiology KW - Gulf War KW - Veterans -- psychology KW - Occupational Exposure -- adverse effects KW - Mental Health KW - Stress, Psychological -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68784754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+traumatic+stress&rft.atitle=Deployment+stressors%2C+gender%2C+and+mental+health+outcomes+among+Gulf+War+I+veterans.&rft.au=Vogt%2C+Dawne+S%3BPless%2C+Anica+P%3BKing%2C+Lynda+A%3BKing%2C+Daniel+W&rft.aulast=Vogt&rft.aufirst=Dawne&rft.date=2005-06-01&rft.volume=18&rft.issue=3&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Journal+of+traumatic+stress&rft.issn=08949867&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-06 N1 - Date created - 2005-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Therapeutic targets for the prevention of type 1 diabetes mellitus. AN - 68466746; 16089357 AB - The pathogenesis of type 1 diabetes is multifactorial, involving genetic susceptibility, autoimmune mechanisms, and environmental factors. This article will focus on two main strategies for altering the underlying disease process in type 1 diabetes. The first strategy is to identify individuals at risk for the development of diabetes and to halt the immune process before it leads to overt clinical disease, Promising in vitro and animal studies with nicotinamide, parenteral insulin, and oral insulin led to large clinical prevention studies, such as the European Nicotinamide Diabetes Intervention Trial and the Diabetes Prevention Trial (DPT-1). These studies failed to show that nicotinamide and insulin prevented the disease in at risk relatives of patients with type 1 diabetes and left many questions unanswered. The second strategy focuses on intervention shortly after diagnosis in order to arrest the destruction of beta cells and to preserve residual beta-cell function as long as possible. Cyclosporin was an effective immunosuppressive but was rejected as a potential treatment for type 1 diabetes because of its renal toxicity. Recently, more attention has been focused on an anti-CD3 antibody, on DiaPep277, and on glutamic acid decarboxylase (GAD). Animal studies and small short-term human trials with these compounds have suggested that they may be effective interventions in patients recently diagnosed with type 1 diabetes. JF - Current drug targets. Immune, endocrine and metabolic disorders AU - Singh, N AU - Palmer, J P AD - Department of Medicine, Division of Endocrinology and Metabolism, Veterans Affairs Puget Sound Healthcare System, Seattle, Washington 98108, USA. Nalini.Singh2@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 227 EP - 236 VL - 5 IS - 2 SN - 1568-0088, 1568-0088 KW - Hypoglycemic Agents KW - 0 KW - Insulin KW - Index Medicus KW - Animals KW - Insulin -- physiology KW - Humans KW - Insulin -- therapeutic use KW - Hypoglycemic Agents -- therapeutic use KW - Diabetes Mellitus, Type 1 -- prevention & control KW - Diabetes Mellitus, Type 1 -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68466746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+targets.+Immune%2C+endocrine+and+metabolic+disorders&rft.atitle=Therapeutic+targets+for+the+prevention+of+type+1+diabetes+mellitus.&rft.au=Singh%2C+N%3BPalmer%2C+J+P&rft.aulast=Singh&rft.aufirst=N&rft.date=2005-06-01&rft.volume=5&rft.issue=2&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Current+drug+targets.+Immune%2C+endocrine+and+metabolic+disorders&rft.issn=15680088&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-23 N1 - Date created - 2005-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gonadotrophin-releasing hormone agonist treatment of aggression in Alzheimer's disease: a case report. AN - 68085587; 16050439 AB - No medication has received regulatory approval in the U.S.A. for the distressing agitation and aggressive behaviors that often complicate dementia. Although studies suggest that several psychotropic medications are sometimes useful for these behavioral problems, response is variable and adverse effects often limit treatment. Theoretical considerations suggest that increasing estrogenic activity or reducing androgenic activity could reduce agitation and aggression in dementia. Estrogen has been reported helpful for these symptoms, but adverse effects are problematic. Chronic administration of the synthetic gonadotropin (luteinising hormone) releasing hormone analogue, goserelin, reduces testosterone activity. Here we describe the apparently sustained elimination of previously treatment-resistant agitation and aggression with goserelin treatment in a 78-year-old male nursing-home resident with Alzheimer's disease. JF - International psychogeriatrics AU - Rosin, Richard A AU - Raskind, Murray A AD - Department of Veterans Affairs, Puget Sound Health Care System Mental Illness Research, Education, and Clinical Center (MIRECC), Seattle, WA 98108, USA. richard.rosin@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 313 EP - 318 VL - 17 IS - 2 SN - 1041-6102, 1041-6102 KW - Amines KW - 0 KW - Antipsychotic Agents KW - Cyclohexanecarboxylic Acids KW - Dibenzothiazepines KW - Goserelin KW - 0F65R8P09N KW - Benzodiazepines KW - 12794-10-4 KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Testosterone KW - 3XMK78S47O KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Valproic Acid KW - 614OI1Z5WI KW - gabapentin KW - 6CW7F3G59X KW - Propranolol KW - 9Y8NXQ24VQ KW - Risperidone KW - L6UH7ZF8HC KW - olanzapine KW - N7U69T4SZR KW - Trazodone KW - YBK48BXK30 KW - Index Medicus KW - Trazodone -- therapeutic use KW - Humans KW - Aged KW - Amines -- therapeutic use KW - Cyclohexanecarboxylic Acids -- therapeutic use KW - Propranolol -- therapeutic use KW - Benzodiazepines -- therapeutic use KW - gamma-Aminobutyric Acid -- therapeutic use KW - Testosterone -- blood KW - Treatment Outcome KW - Valproic Acid -- therapeutic use KW - Risperidone -- therapeutic use KW - Dibenzothiazepines -- therapeutic use KW - Male KW - Gonadotropin-Releasing Hormone -- agonists KW - Aggression -- drug effects KW - Alzheimer Disease -- complications KW - Aggression -- psychology KW - Antipsychotic Agents -- therapeutic use KW - Alzheimer Disease -- drug therapy KW - Alzheimer Disease -- psychology KW - Antipsychotic Agents -- adverse effects KW - Goserelin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68085587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+psychogeriatrics&rft.atitle=Gonadotrophin-releasing+hormone+agonist+treatment+of+aggression+in+Alzheimer%27s+disease%3A+a+case+report.&rft.au=Rosin%2C+Richard+A%3BRaskind%2C+Murray+A&rft.aulast=Rosin&rft.aufirst=Richard&rft.date=2005-06-01&rft.volume=17&rft.issue=2&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=International+psychogeriatrics&rft.issn=10416102&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-27 N1 - Date created - 2005-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuroleptic malignant syndrome in a patient with Parkinson's disease: a case study. AN - 68013435; 16001822 AB - Neuroleptic malignant syndrome (NMS) is a potentially lethal condition that has been described in patients with idiopathic Parkinson's disease (PD) after long-term dopaminergic medications are suddenly stopped or moderately decreased. If patients with PD develop severe rigidity, stupor, and hyperthermia, L-Dopa withdrawal should be suspected and the dopaminergic drug restarted as soon as possible to prevent rhabdomyolysis and renal failure. Nurses who are knowledgeable about NMS can provide prompt identification of the PD patient's condition and prevent a potentially lethal cascade of symptoms. JF - The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses AU - Ward, Constance AD - Neurology Care Line-127PD 2002 Holcombe Blvd., Houston, TX 77030, USA. constance.ward@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 160 EP - 162 VL - 37 IS - 3 SN - 0888-0395, 0888-0395 KW - Antiparkinson Agents KW - 0 KW - Dopamine Agents KW - Electrolytes KW - Muscle Relaxants, Central KW - Levodopa KW - 46627O600J KW - Dantrolene KW - F64QU97QCR KW - Index Medicus KW - Nursing KW - Magnetic Resonance Imaging KW - Humans KW - Aged KW - Dantrolene -- therapeutic use KW - Physical Examination KW - Leukocyte Count KW - Electrolytes -- blood KW - Fever -- etiology KW - Confusion -- etiology KW - Dehydration -- etiology KW - Nursing Assessment KW - Deep Brain Stimulation KW - Muscle Relaxants, Central -- therapeutic use KW - Drug Monitoring KW - Nurse's Role KW - Urinalysis KW - Time Factors KW - Male KW - Antiparkinson Agents -- adverse effects KW - Neuroleptic Malignant Syndrome -- etiology KW - Substance Withdrawal Syndrome -- complications KW - Parkinson Disease -- therapy KW - Neuroleptic Malignant Syndrome -- diagnosis KW - Parkinson Disease -- complications KW - Dopamine Agents -- adverse effects KW - Neuroleptic Malignant Syndrome -- therapy KW - Levodopa -- adverse effects KW - Neuroleptic Malignant Syndrome -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68013435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.atitle=Neuroleptic+malignant+syndrome+in+a+patient+with+Parkinson%27s+disease%3A+a+case+study.&rft.au=Ward%2C+Constance&rft.aulast=Ward&rft.aufirst=Constance&rft.date=2005-06-01&rft.volume=37&rft.issue=3&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.issn=08880395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-08 N1 - Date created - 2005-07-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Repeated psychological stress testing in stimulant-dependent patients. AN - 67991531; 15913869 AB - Decreasing response to stress has been one goal of interventions aimed at reducing relapse to substances of abuse. A laboratory stress test that can be repeated would be helpful in testing the efficacy of interventions in decreasing the response to stress before more extensive trials are begun. The effects of two types of psychological stress tests, the Trier Social Stress Test (TSST) and a stress imagery test, on psychological, physiological, and hormonal responses (salivary cortisol and DHEA) were examined when each test was given twice to cocaine- or methamphetamine-dependent human subjects, 24 of whom completed at least one session. The stress imagery test produced significant changes in several of the subjective response measures in both first and second sessions, including several measures of negative affect and a craving measure. The TSST produced significant changes only in the second session. The stress imagery protocol showed better replicability across two sessions. Cocaine users and methamphetamine users did not respond similarly in their craving responses. Reported craving for methamphetamine after stress testing showed decreases or much smaller increases compared to that for cocaine. Neither stress test significantly increased salivary cortisol or DHEA, and changes in hormone concentrations were not related to subjective responses. These results suggest that stress imagery testing procedures may be useful as provocative tests of stress-induced affect and stimulant drug craving. Although less convincing because of the heterogeneity of the subjects, they also suggest that HPA axis responsivity is not clearly linked to acute stress-induced stimulant craving or affective response. JF - Progress in neuro-psychopharmacology & biological psychiatry AU - Harris, Debra S AU - Reus, Victor I AU - Wolkowitz, Owen M AU - Mendelson, John E AU - Jones, Reese T AD - Drug Dependence Research Center, Langley Porter Psychiatric Institute, Department of Psychiatry, University of California, San Francisco, CA, USA. debra.harris@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 669 EP - 677 VL - 29 IS - 5 SN - 0278-5846, 0278-5846 KW - Central Nervous System Stimulants KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Dehydroepiandrosterone KW - 459AG36T1B KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Blood Pressure -- physiology KW - Affect -- drug effects KW - Humans KW - Cocaine-Related Disorders -- psychology KW - Aged KW - Amphetamine-Related Disorders -- psychology KW - Hydrocortisone -- metabolism KW - Smoking -- psychology KW - Dehydroepiandrosterone -- metabolism KW - Imagination KW - Psychiatric Status Rating Scales KW - Saliva -- metabolism KW - Middle Aged KW - Blood Pressure -- drug effects KW - Female KW - Male KW - Social Environment KW - Stress, Psychological -- diagnosis KW - Substance-Related Disorders -- psychology KW - Stress, Psychological -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67991531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+neuro-psychopharmacology+%26+biological+psychiatry&rft.atitle=Repeated+psychological+stress+testing+in+stimulant-dependent+patients.&rft.au=Harris%2C+Debra+S%3BReus%2C+Victor+I%3BWolkowitz%2C+Owen+M%3BMendelson%2C+John+E%3BJones%2C+Reese+T&rft.aulast=Harris&rft.aufirst=Debra&rft.date=2005-06-01&rft.volume=29&rft.issue=5&rft.spage=669&rft.isbn=&rft.btitle=&rft.title=Progress+in+neuro-psychopharmacology+%26+biological+psychiatry&rft.issn=02785846&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-26 N1 - Date created - 2005-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mentoring surgeons in private and academic practice. AN - 67951141; 15967909 AB - Mentoring is an essential component of a successful career in any profession, and these relationships are beginning to be explored in great detail in academic surgery. However, it is equally important for surgeons in private practice, and this area has not received nearly as much attention in the literature. The goals for both are similar and include providing career advice, guidance, and counseling, with the only regard being the success of the junior associate. In private practice, the mentor can be a senior colleague who may or may not be part of one's group practice. In academia, it may be someone at another university, although proximity is preferable. It may be necessary to repeat the search for a mentor more than once before a successful relationship evolves. This complex process must be mastered if one is to be successful in either academia or private practice. JF - Archives of surgery (Chicago, Ill. : 1960) AU - Hoover, Eddie L AD - Department of Surgery, Buffalo Veterans Affairs Medical Center and State University of New York at Buffalo, 14215, USA. eddie.hoover@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 598 EP - 608 VL - 140 IS - 6 SN - 0004-0010, 0004-0010 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Life Change Events KW - Substance-Related Disorders KW - Faculty, Medical KW - Schools, Medical KW - Private Practice KW - Interpersonal Relations KW - General Surgery -- education KW - Mentors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67951141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+surgery+%28Chicago%2C+Ill.+%3A+1960%29&rft.atitle=Mentoring+surgeons+in+private+and+academic+practice.&rft.au=Hoover%2C+Eddie+L&rft.aulast=Hoover&rft.aufirst=Eddie&rft.date=2005-06-01&rft.volume=140&rft.issue=6&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=Archives+of+surgery+%28Chicago%2C+Ill.+%3A+1960%29&rft.issn=00040010&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-05 N1 - Date created - 2005-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Functioning and health service use among elderly nursing home residents with alcohol use disorders: findings from the National Nursing Home Survey. AN - 67929670; 15956267 AB - The author asked whether older nursing home residents with alcohol use disorders differ from demographically-matched residents without alcohol use disorders on functioning, admission characteristics, and health services use. National Nursing Home Survey data were used to compare nursing home residents with alcohol use disorders (N=216) with demographically-matched residents without alcohol use disorders (N=216) on functioning, admission characteristics, and health services use. Residents with alcohol use disorders functioned somewhat better than did residents in the demographically-matched sample group, as indicated by performance of basic activities of daily living. However, they were significantly more likely to have lived alone before admission and to have obtained mental health and social services. There was a significant group x gender interaction on length of stay: men with alcohol use disorders had shorter lengths of stay than did men without alcohol use disorders; women with alcohol use disorders had longer lengths of stay than did women without such disorders. Having fewer social resources may contribute to elevated admission risk and need for mental health and social services among older nursing home residents who have alcohol use disorders. Duration and severity of alcohol problems may help explain gender differences in length of stay among these residents. JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry AU - Brennan, Penny L AD - Center for Health Care Evaluation (152- VA Palo Alto Health Care System, Menlo Park Division, 795 Willow Road, Menlo Park, CA 94025, USA. penny.brennan@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 475 EP - 483 VL - 13 IS - 6 SN - 1064-7481, 1064-7481 KW - Index Medicus KW - Demography KW - Humans KW - Patient Admission -- statistics & numerical data KW - Mental Health Services -- utilization KW - Aged KW - Activities of Daily Living KW - United States -- epidemiology KW - Male KW - Female KW - Social Work -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Health Services -- utilization KW - Surveys and Questionnaires KW - Nursing Homes -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67929670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+geriatric+psychiatry+%3A+official+journal+of+the+American+Association+for+Geriatric+Psychiatry&rft.atitle=Functioning+and+health+service+use+among+elderly+nursing+home+residents+with+alcohol+use+disorders%3A+findings+from+the+National+Nursing+Home+Survey.&rft.au=Brennan%2C+Penny+L&rft.aulast=Brennan&rft.aufirst=Penny&rft.date=2005-06-01&rft.volume=13&rft.issue=6&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+geriatric+psychiatry+%3A+official+journal+of+the+American+Association+for+Geriatric+Psychiatry&rft.issn=10647481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-06-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A survey of PTSD screening and referral practices in VA addiction treatment programs. AN - 67882615; 15925265 AB - Veterans with posttraumatic stress disorder (PTSD) and substance use disorders (SUDs) demonstrate worse outcomes following treatment for SUDs than do veterans with SUDs only, and so PTSD treatment may enhance SUD outcomes for patients. A survey of current practice patterns in VA SUD treatment programs was undertaken to determine their concurrence with emerging practice guidelines for the assessment and treatment of SUD-PTSD comorbidity. Clinicians in outpatient SUD clinics and/or inpatient SUD programs were surveyed in six VA medical centers in 1999 and 2001 (respondents n = 57 and n = 39, respectively). Although one half to two thirds of clinicians working with SUD patients routinely screen for trauma exposure and PTSD, few assessments are systematically conducted using validated measures. Routine referrals to PTSD specialty and dual-diagnosis programs and to veterans' centers are made by between 35% and 60% of providers across inpatient and outpatient settings. Implications for improvement of clinical outcomes are discussed. JF - Journal of substance abuse treatment AU - Young, Helena E AU - Rosen, Craig S AU - Finney, John W AD - National Center for PTSD, VA Palo Alto Health Care System, Menlo Park, CA 94025, USA. helena.young@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 313 EP - 319 VL - 28 IS - 4 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - United States Department of Veterans Affairs KW - Humans KW - United States -- epidemiology KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Referral and Consultation -- statistics & numerical data KW - Substance Abuse Treatment Centers KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Surveys and Questionnaires KW - Substance-Related Disorders -- rehabilitation KW - Mass Screening -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67882615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=A+survey+of+PTSD+screening+and+referral+practices+in+VA+addiction+treatment+programs.&rft.au=Young%2C+Helena+E%3BRosen%2C+Craig+S%3BFinney%2C+John+W&rft.aulast=Young&rft.aufirst=Helena&rft.date=2005-06-01&rft.volume=28&rft.issue=4&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-08 N1 - Date created - 2005-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pain and use of alcohol to manage pain: prevalence and 3-year outcomes among older problem and non-problem drinkers. AN - 67874741; 15918808 AB - Most older adults report having recently experienced pain, and many older adults have late-life drinking problems. However, to our knowledge, the intersection of pain and alcohol misuse by older adults has not been studied. This research focuses on the implications of pain for older individuals who have problems with alcohol. Longitudinal survey. SETTING, PARTICIPANTS AND MEASUREMENT: Older community-residing adults (n = 401) were classified as problem and non-problem drinkers. At baseline and 3 years later they were asked to provide information about their pain, use of alcohol to manage pain, drinking behavior, chronic health problems and recent serious injury. At baseline, older problem drinkers reported more severe pain, more disruption of daily activities due to pain and more frequent use of alcohol to manage pain than did older non-problem drinkers. More pain was associated with more use of alcohol to manage pain; this relationship was stronger among older adults with drinking problems than among those without drinking problems. Among older men, more baseline drinking problems interacted with use of alcohol to manage pain to predict more health problems and serious injury 3 years later. Among older women, more baseline drinking problems interacted with use of alcohol to manage pain to predict more drinking problems 3 years later. The results highlight the importance of monitoring the drinking behavior of older patients who present with pain complaints, especially patients who have pre-existing problems with alcohol. JF - Addiction (Abingdon, England) AU - Brennan, Penny L AU - Schutte, Kathleen K AU - Moos, Rudolf H AD - Center for Health Care Evaluation and Program Evaluation and Resource Center, VA Palo Alto Health Care System and Stanford University Medical Center, CA, USA. penny.brennan@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 777 EP - 786 VL - 100 IS - 6 SN - 0965-2140, 0965-2140 KW - Index Medicus KW - Pain Management KW - Attitude to Health KW - Risk Factors KW - Humans KW - Surveys and Questionnaires KW - Aged KW - Activities of Daily Living KW - Middle Aged KW - Longitudinal Studies KW - Male KW - Female KW - Prevalence KW - Alcoholism -- epidemiology KW - Pain -- psychology KW - Alcohol Drinking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67874741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Pain+and+use+of+alcohol+to+manage+pain%3A+prevalence+and+3-year+outcomes+among+older+problem+and+non-problem+drinkers.&rft.au=Brennan%2C+Penny+L%3BSchutte%2C+Kathleen+K%3BMoos%2C+Rudolf+H&rft.aulast=Brennan&rft.aufirst=Penny&rft.date=2005-06-01&rft.volume=100&rft.issue=6&rft.spage=777&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-28 N1 - Date created - 2005-05-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Addiction. 2005 Jun;100(6):731-2 [15918799] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phenazopyridine-induced sulfhemoglobinemia. AN - 67833697; 15886294 AB - To report a case of sulfhemoglobinemia in a patient receiving phenazopyridine for a urinary tract infection. A 63-year-old white woman presented to the emergency department with complaints of fatigue and bluish discoloration of her body that had gradually progressed over the previous 6-8 weeks. About 4 months prior to presenting to the emergency department, she had started taking phenazopyridine, an over-the-counter medication for symptoms of dysuria. Because the cyanosis did not improve after the patient received oxygen and methylene blue, sulfhemoglobinemia was suspected and confirmed by spectrophotometer analysis. Sulfhemoglobin is a green-pigmented molecule containing a sulfur atom in one or more of the porphyrin rings. It is a rare cause of cyanosis, which is usually drug induced. Sulfhemoglobinemia is suspected when a cyanotic patient has normal to near-normal oxygen tension, laboratory reports of elevated methemoglobin, and does not respond to methylene blue therapy. Sulfhemoglobinemia is relatively rare, despite the widespread use of drugs that have been reported to cause it. Predisposing factors, such as chronic constipation, present in our patient, have been suggested as a source of hydrogen sulfide. This case of sulfhemoglobinemia, which occurred after the patient took phenazopyridine, is considered a probable adverse event according to the Naranjo probability scale. JF - The Annals of pharmacotherapy AU - Gopalachar, Anuradha S AU - Bowie, Venita L AU - Bharadwaj, Parag AD - Amarillo Veterans Affairs Medical Center, Amarillo, TX 79106-1991, USA. Anuradha.gopalachar@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 1128 EP - 1130 VL - 39 IS - 6 SN - 1060-0280, 1060-0280 KW - Phenazopyridine KW - K2J09EMJ52 KW - Index Medicus KW - Administration, Oral KW - Urinary Tract Infections -- drug therapy KW - Humans KW - Middle Aged KW - Female KW - Phenazopyridine -- adverse effects KW - Phenazopyridine -- administration & dosage KW - Sulfhemoglobinemia -- diagnosis KW - Sulfhemoglobinemia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67833697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Phenazopyridine-induced+sulfhemoglobinemia.&rft.au=Gopalachar%2C+Anuradha+S%3BBowie%2C+Venita+L%3BBharadwaj%2C+Parag&rft.aulast=Gopalachar&rft.aufirst=Anuradha&rft.date=2005-06-01&rft.volume=39&rft.issue=6&rft.spage=1128&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2005-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A psychometric evaluation of the Fagerström Test for Nicotine Dependence in PTSD smokers. AN - 67827471; 15893100 AB - Rates of smoking among individuals with psychiatric conditions are greater than rates seen in the general population, yet little is known about the psychometric properties of commonly used nicotine dependence instruments among psychiatric smokers. This study examined the reliability, validity, and factor structure of the Fagerström Test for Nicotine Dependence (FTND) among psychiatric smokers. Results revealed that the FTND had good test-retest reliability, convergent validity, and discriminant validity. A factor-analytic examination converged on a two-factor solution, reflecting two correlated but separate processes related to nicotine dependence. In total, the results revealed that the FTND performs as well--from a psychometric perspective--with psychiatric smokers, as it does with nonpsychiatric smokers. JF - Addictive behaviors AU - Buckley, Todd C AU - Mozley, Susannah L AU - Holohan, Dana R AU - Walsh, Kate AU - Beckham, Jean C AU - Kassel, Jon D AD - National Center for PTSD, VA Boston Healthcare System, MA 02131-4817, USA. Todd.Buckley@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 1029 EP - 1033 VL - 30 IS - 5 SN - 0306-4603, 0306-4603 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Reproducibility of Results KW - Humans KW - Nicotine -- analysis KW - Middle Aged KW - Male KW - Female KW - Stress Disorders, Post-Traumatic -- psychology KW - Stress Disorders, Post-Traumatic -- complications KW - Psychometrics -- methods KW - Psychological Tests -- standards KW - Tobacco Use Disorder -- psychology KW - Smoking -- psychology KW - Tobacco Use Disorder -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67827471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=A+psychometric+evaluation+of+the+Fagerstr%C3%B6m+Test+for+Nicotine+Dependence+in+PTSD+smokers.&rft.au=Buckley%2C+Todd+C%3BMozley%2C+Susannah+L%3BHolohan%2C+Dana+R%3BWalsh%2C+Kate%3BBeckham%2C+Jean+C%3BKassel%2C+Jon+D&rft.aulast=Buckley&rft.aufirst=Todd&rft.date=2005-06-01&rft.volume=30&rft.issue=5&rft.spage=1029&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-13 N1 - Date created - 2005-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of novel genetic loci for bone size and mechanosensitivity in an ENU mutant exhibiting decreased bone size. AN - 67810450; 15883645 AB - Using a dominant ENU mutagenesis screen in C57BL/6J (B6) mice to reveal gene function, we identified a mutant, 917M, with a reduced bone size phenotype, which is expressed only in males. We show that mutation results in osteoblasts with reduced proliferation, increased apoptosis, and an impaired response to in vitro mechanical load. The mutation is mapped to a novel locus (LOD score of 7.9 at 10.5 cM) on chromosome 4. Using a dominant ENU mutagenesis screen in C57BL/6J (B6) mice to reveal gene function, we identified a mutant, 917M, with a reduced bone size phenotype, which is expressed only in males. In this report, we show the chromosomal location of this mutation using linkage analysis and cellular characterization of the mutant phenotype. The mutant mouse was bred to wildtype B6 to produce progeny for characterization of the bone size phenotype. Periosteal osteoblasts isolated from the tibia and femur of mutant and wildtype mice were studied for proliferation, differentiation, and apoptosis potential. To determine the chromosomal location of the mutation, a low-resolution linkage map was established by completing a genome-wide scan in B6C3H F2 male mice generated from intercross breeding of mutant mice. Mutant progeny (16 weeks old) displayed a total body bone area that was 10-13% lower and a periosteal circumference that was 5-8% lower at the femur and tibia midshaft compared with wildtype B6 mice. Periosteal osteoblasts from mutant mice showed 17-27% reduced cell proliferation and 23% increased apoptosis compared with wildtype controls. In addition, osteoblasts from mutant mice showed an impaired response to shear stress-induced proliferation rate, an in vitro model for mechanical loading. Interval mapping in B6C3H F2 males (n = 69) indicated two major loci affecting bone size on chromosome 1 at 45 cM (LOD 4.9) and chromosome 4 at 10.5 cM (LOD 7.9, genome-wide p < 0.01). Interval mapping using body weight as covariate revealed only one significant interval at chromosome 4 (LOD 6.8). Alleles of the chromosome 4 interval inherited from the B6 mutant strain contributed to a significantly lower bone size than those inherited from C3H. A pairwise interaction analysis showed evidence for a significant interaction between loci on chromosome 1 with the chromosome 4 quantitative trait loci. The 917M locus on chromosome 4 seems to be novel because it does not correspond with those loci previously associated with bone size on chromosome 4 in B6 and C3H/HeJ mice or other crosses. JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research AU - Srivastava, Apurva K AU - Kapur, Sanjay AU - Mohan, Suburaman AU - Yu, Hongrun AU - Kapur, Sonia AU - Wergedal, Jon AU - Baylink, David J AD - Musculoskeletal Disease Center, Jerry L. Pettis Veterans Administration Medical Center, Loma Linda, California 92357, USA. Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 1041 EP - 1050 VL - 20 IS - 6 SN - 0884-0431, 0884-0431 KW - Alkylating Agents KW - 0 KW - Mutagens KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Osteoblasts -- metabolism KW - Animals KW - Apoptosis KW - Sex Factors KW - Bone Resorption KW - Quantitative Trait Loci KW - Cell Differentiation KW - Mice KW - Cell Proliferation KW - Chromosome Mapping KW - Genome KW - Osteoblasts -- cytology KW - Phenotype KW - Alleles KW - Lod Score KW - Stress, Mechanical KW - Models, Genetic KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Crosses, Genetic KW - Mutation KW - Female KW - Male KW - Bone and Bones -- physiology KW - Bone and Bones -- drug effects KW - Bone and Bones -- anatomy & histology KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67810450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.atitle=Identification+of+novel+genetic+loci+for+bone+size+and+mechanosensitivity+in+an+ENU+mutant+exhibiting+decreased+bone+size.&rft.au=Srivastava%2C+Apurva+K%3BKapur%2C+Sanjay%3BMohan%2C+Suburaman%3BYu%2C+Hongrun%3BKapur%2C+Sonia%3BWergedal%2C+Jon%3BBaylink%2C+David+J&rft.aulast=Srivastava&rft.aufirst=Apurva&rft.date=2005-06-01&rft.volume=20&rft.issue=6&rft.spage=1041&rft.isbn=&rft.btitle=&rft.title=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.issn=08840431&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-03 N1 - Date created - 2005-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Using Remote Assessment to Provide Home Modification Services to Underserved Elders AN - 61433250; 200505255 AB - Purpose: Although remote home assessment would enable specialists to prescribe home modifications for anyone, anywhere, the strategy is dependent on the ability to provide specialists with the same information as an in-home assessment. The purpose of this paper is to document that remote assessment is feasible & concurs largely with traditional in-home assessment based on expert judgment. Design and Methods: We compared two new remote assessments, a "zero-tech" paper-&-pencil protocol & a "high-tech" televideo protocol, to traditional in-home assessments to determine the equivalence of the remote & in-home assessments. We determined equivalence by comparing each of the remote assessments to a traditional in-home assessment in the same home. In-home assessments were conducted by home-modification specialists in all homes. Data collection for the remote protocols was conducted by individuals inexperienced in home modification. Assessment data from the remote protocols were analyzed by specialists to diagnose problems & prescribe solutions. Results: The overall rates of correct problem identification (i.e., Sensitivity + Specificity) were significant (p =.000) for both the remote paper-&-pencil (96.4%) & remote televideo (87.1%) protocols. Similarly, rates of agreement in recommendations of solutions were significant (p =.000) for both remote assessments (78.8% & 77.4%, respectively). Implications: The need for home-modification services, particularly in rural areas, far exceeds the capacity of specialists to provide them. Our findings suggest that remote assessments can potentially be used to identify mobility & safety problems in the home as well as to recommend solutions to those problems. As a result, remote home assessment has the potential to provide underserved elders with access to home-modification services that have heretofore eluded them. 2 Tables, 6 Figures, 13 References. Adapted from the source document. JF - The Gerontologist AU - Sanford, Jon A AU - Butterfield, Tina AD - Atlanta VA Medical Center, Rehab R&D Center, Decatur, GA jon.sanford@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 389 EP - 398 VL - 45 IS - 3 SN - 0016-9013, 0016-9013 KW - Home modifications, Aging in place, Home assessment KW - Evaluation KW - Safety KW - Elderly KW - Activities of Daily Living KW - Home Health Care KW - Living Conditions KW - Rural Areas KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61433250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=Using+Remote+Assessment+to+Provide+Home+Modification+Services+to+Underserved+Elders&rft.au=Sanford%2C+Jon+A%3BButterfield%2C+Tina&rft.aulast=Sanford&rft.aufirst=Jon&rft.date=2005-06-01&rft.volume=45&rft.issue=3&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Number of references - 13 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Home Health Care; Elderly; Living Conditions; Evaluation; Rural Areas; Safety; Activities of Daily Living ER - TY - JOUR T1 - Effects of Transdermal Nicotine during Imaginal Exposure to Anxiety and Smoking Cues in College Smokers AN - 57129674; 200601765 AB - In a 2 (patch) x 2 (smoking) x 2 (anxiety) mixed design, 52 undergraduate smokers randomly received a nicotine (21 mg) or placebo patch. After a 4-hr nicotine absorption/deprivation period, participants imagined several scenarios varying in cue content: (a) anxiety plus smoking, (b) anxiety, (c) smoking, and (d) neutral. Although smoking urge increased in both the nicotine and placebo conditions after the absorption/deprivation period, those who received the placebo reported significantly greater urge. During the cue reactivity trials, a significant Patch x Smoking x Anxiety interaction effect was observed for urge. However, participants who received nicotine still experienced moderate urges, indicating that nicotine did not attenuate cue-elicited urge. Transdermal nicotine did not diminish anxiety during the absorption/deprivation period or in response to the cues. Illustrations, Tables, References. [Copyright 2005 The American Psychological Association.] JF - Psychology of Addictive Behaviors AU - Morissette, Sandra Baker AU - Palfai, Tibor P AU - Gulliver, Suzy Bird AU - Spiegel, David A AU - Barlow, David H AD - Veterans Affairs Boston Health Care System, Boston, MA sandra.morissette@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 192 EP - 198 VL - 19 IS - 2 SN - 0893-164X, 0893-164X KW - Nicotine patches KW - Anxiety KW - Smokers KW - Addiction KW - Undergraduate students KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57129674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Addictive+Behaviors&rft.atitle=Effects+of+Transdermal+Nicotine+during+Imaginal+Exposure+to+Anxiety+and+Smoking+Cues+in+College+Smokers&rft.au=Morissette%2C+Sandra+Baker%3BPalfai%2C+Tibor+P%3BGulliver%2C+Suzy+Bird%3BSpiegel%2C+David+A%3BBarlow%2C+David+H&rft.aulast=Morissette&rft.aufirst=Sandra&rft.date=2005-06-01&rft.volume=19&rft.issue=2&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/10.1037%2F0893-164X.19.2.192 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - PABEEI N1 - SubjectsTermNotLitGenreText - Undergraduate students; Nicotine patches; Addiction; Smokers; Anxiety DO - http://dx.doi.org/10.1037/0893-164X.19.2.192 ER - TY - JOUR T1 - Evaluating Potentially Modifiable Risk Factors for Prevalent and Incident Nocturia in Older Adults AN - 20716248; 6272401 AB - Objectives: To examine associations between nocturia and potentially modifiable risk factors in older adults. Design: Secondary analysis of cross-sectional and longitudinal data. Setting: Respondents were selected using population-based sampling, drawing from a single Michigan county in 1983. They were followed through 1990. Participants: Community-living adults aged 60 and older. Measurements: Episodes of nocturia, development of nocturia at 2 years after baseline survey, age, sex, hypertension, diabetes mellitus, drinking fluids before bedtime, amount of fluid intake before bedtime, diuretic use, and 24-hour coffee intake. All measures were self-reported. Results: Bivariate cross-sectional analysis revealed significant associations with two or more episodes of nocturia for hypertension (odds ratio (OR)=1.7, 95% confidence interval (CI)=1.37-2.1), diabetes mellitus (OR=1.51, 95% CI=1.1-2.0), diuretic use (OR=1.7, 95% CI=1.3-2.1), age (OR=1.05 per additional year over 60, 95% 1.03-1.06), and number of cups of coffee (OR=0.93 for each cup of coffee, 95% CI=0.89-0.97). In multivariate analysis, hypertension (OR=1.52, 95% CI=1.2-1.9), diuretic use (OR=1.3, 95% 95% CI=1.0-1.7), and age (OR=1.04 per additional year over 60, 95% 1.03-1.06) were independently associated with two or more nocturia episodes per night. No baseline factors predicted future development of nocturia (save for age, in one model). Conclusion: Hypertension, older age, and diuretic use were independently associated with two or more episodes of nocturia in cross-sectional analysis. No baseline factor was related to the development of nocturia over a 2-year interval in this sample. Nighttime fluid intake and coffee intake, practices providers commonly target in patients with nocturia, were not associated with nocturia in this population-based sample of community-living older adults. JF - Journal of the American Geriatrics Society AU - Johnson, Theodore M AU - Sattin, Richard W AU - Parmelee, Patricia AU - Fultz, Nancy H AU - Ouslander, Joseph G AD - Theodore M. Johnson II, Birmingham-Atlanta GRECC, 508-11B, Atlanta VAMC, 1670 Clairmont Road, Decatur, GA 30033, Ted.Johnson@med.va.gov Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 1011 EP - 1016 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 53 IS - 6 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - Age KW - diabetes mellitus KW - secondary analysis KW - hypertension KW - coffee KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20716248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Evaluating+Potentially+Modifiable+Risk+Factors+for+Prevalent+and+Incident+Nocturia+in+Older+Adults&rft.au=Johnson%2C+Theodore+M%3BSattin%2C+Richard+W%3BParmelee%2C+Patricia%3BFultz%2C+Nancy+H%3BOuslander%2C+Joseph+G&rft.aulast=Johnson&rft.aufirst=Theodore&rft.date=2005-06-01&rft.volume=53&rft.issue=6&rft.spage=1011&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2005.53321.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - SuppNotes - Figures, 1; tables, 2; references, 30. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - diabetes mellitus; Age; secondary analysis; coffee; hypertension DO - http://dx.doi.org/10.1111/j.1532-5415.2005.53321.x ER - TY - JOUR T1 - CD4 super(+) CD25 super(+) T Cells Prevent Arthritis Associated with Borrelia Vaccination and Infection AN - 17629352; 6416917 AB - CD4 super(+) CD25 super(+) T cells are a population of regulatory T cells associated with control of arthritis in anti-interleukin-17 antibody-treated Borrelia-vaccinated and challenged gamma interferon-deficient mice. Here, we present direct evidence that adoptive transfer of enriched CD4 super(+) CD25 super(+) T cells from these mice can prevent the development of arthritis in Borrelia-vaccinated and challenged mice. These findings establish a major role for CD4 super(+) CD25 super(+) T cells in the prevention of arthritis in Borrelia-vaccinated and challenged animals. JF - Clinical and Diagnostic Laboratory Immunology AU - Nardelli, Dean T AU - Cloute, Joseph P AU - Luk, KHKevin AU - Torrealba, Jose AU - Warner, Thomas F AU - Callister, Steven M AU - Schell, Ronald F AD - Wisconsin State Laboratory of Hygiene. Departments of Comparative Biomedical Sciences. Bacteriology. Medical Microbiology and Immunology. Pathology and Laboratory Medicine. Surgery, University of Wisconsin. Department of Pathology, Veterans Administration Hospital, Madison. Microbiology Research Laboratory and Section of Infectious Diseases, Gundersen Lutheran Medical Center, La Crosse, Wisconsin Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 786 EP - 792 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 12 IS - 6 SN - 1071-412X, 1071-412X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - J 02833:Immune response and immune mechanisms KW - F 06322:Rheumatoid Arthritis: Clinical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17629352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Diagnostic+Laboratory+Immunology&rft.atitle=CD4+super%28%2B%29+CD25+super%28%2B%29+T+Cells+Prevent+Arthritis+Associated+with+Borrelia+Vaccination+and+Infection&rft.au=Nardelli%2C+Dean+T%3BCloute%2C+Joseph+P%3BLuk%2C+KHKevin%3BTorrealba%2C+Jose%3BWarner%2C+Thomas+F%3BCallister%2C+Steven+M%3BSchell%2C+Ronald+F&rft.aulast=Nardelli&rft.aufirst=Dean&rft.date=2005-06-01&rft.volume=12&rft.issue=6&rft.spage=786&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Diagnostic+Laboratory+Immunology&rft.issn=1071412X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Bioactivation of Latent Transforming Growth Factor beta 1 by Mycobacterium tuberculosis in Human Mononuclear Phagocytes AN - 17536570; 6405895 AB - Biologically active transforming growth factor beta 1 (TGF beta 1) has been identified at sites of Mycobacterium tuberculosis (MTB) infection in the lung; however, the underlying mechanism(s) for its activation is not clear. Here using an enzyme-linked immunospot assay for TGF beta 1, we show that human blood monocytes (MN) and alveolar macrophages (AM) produce bioactive TGF beta 1 upon stimulation by MTB. However, only MTB-stimulated MN increased TGF beta 1 production on a per cell basis. The frequency of TGF beta 1-producing MN was reduced by an inhibitor of plasmin, bdellin, indicating a role for plasmin pathways in the bioactivation of cytokine. The expression of urokinase plasminogen activator receptor (uPAR) mRNA and both surface and soluble uPAR (CD87) was increased in MTB-activated MN. However, antibody neutralization of uPAR suppressed bioactive TGF beta 1 in MN alone. Thus, the more immature MN, which are continuously recruited to the lung during tuberculosis (TB), have a higher capacity to bioactivate TGF beta 1 by expression of components of the plasmin pathway. Excess production and bioactivation of TGF beta 1 at sites of MTB infection may undermine host immune responses during TB. JF - Scandinavian Journal of Immunology AU - Aung, H AU - Wu, M AU - Johnson, J L AU - Hirsch, C S AU - Toossi, Z AD - Division of Infectious Disease, Department of Medicine, Case Western Reserve University; and Veterans' Administration Medical Center, Cleveland, OH, USA, zxt2@po.cwru.edu Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 558 EP - 565 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 61 IS - 6 SN - 0300-9475, 0300-9475 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Infection KW - Transforming growth factor-^b1 KW - Transforming growth factor-b1 KW - Phagocytes KW - Transforming growth factor-^b KW - Cytokines KW - Tuberculosis KW - Monocytes KW - Manganese KW - plasminogen KW - Enzyme-linked immunosorbent assay KW - mRNA KW - Blood KW - Plasmin KW - Antibodies KW - Lung KW - u-Plasminogen activator KW - Mycobacterium tuberculosis KW - F 06106:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17536570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Immunology&rft.atitle=Bioactivation+of+Latent+Transforming+Growth+Factor+beta+1+by+Mycobacterium+tuberculosis+in+Human+Mononuclear+Phagocytes&rft.au=Aung%2C+H%3BWu%2C+M%3BJohnson%2C+J+L%3BHirsch%2C+C+S%3BToossi%2C+Z&rft.aulast=Aung&rft.aufirst=H&rft.date=2005-06-01&rft.volume=61&rft.issue=6&rft.spage=558&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Immunology&rft.issn=03009475&rft_id=info:doi/10.1111%2Fj.1365-3083.2005.01623.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - Figures, 7; references, 29. N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Transforming growth factor-b1; Manganese; Plasmin; Infection; Lung; Tuberculosis; u-Plasminogen activator; Monocytes; Phagocytes; Enzyme-linked immunosorbent assay; Cytokines; Transforming growth factor-^b1; Blood; mRNA; Antibodies; Macrophages; plasminogen; Transforming growth factor-^b DO - http://dx.doi.org/10.1111/j.1365-3083.2005.01623.x ER - TY - JOUR T1 - Increased Sensitivity to Staphylococcal Enterotoxin B following Adenoviral Infection AN - 17490751; 6274229 AB - Staphylococcal enterotoxin B induces toxic shock and is a major virulence factor of staphylococcal diseases. We examined the effects of systemic adenoviral infection on responses to staphylococcal enterotoxin B in a murine model. We found that adenoviral infection markedly increases the severity of liver injury following exposure to staphylococcal enterotoxin B without D-galactosamine sensitization. In adenovirus-infected mice, staphylococcal enterotoxin B triggered a more profound hypothermia and increased apoptosis in the liver. Consistent with these observations, we also found that adenoviral infection primed for an increased production of gamma interferon in vivo and in vitro following stimulation with staphylococcal enterotoxin B. Gamma-interferon-knockout mice did not show increased sensitivity to staphylococcal enterotoxin B following adenoviral infection. These data suggest that a preexisting viral infection primes mice for subsequent staphylococcal enterotoxin B exposure, possibly via a gamma-interferon-mediated mechanism. JF - Infection and Immunity AU - Yarovinsky, Timur O AU - Mohning, Michael P AU - Bradford, Mary A AU - Monick, Martha M AU - Hunninghake, Gary W AD - University of Iowa Roy J. and Lucille A. Carver College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242 Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 3375 EP - 3384 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 6 SN - 0019-9567, 0019-9567 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - gamma -Interferon KW - Hypothermia KW - Apoptosis KW - virulence factors KW - Adenovirus KW - Liver KW - Animal models KW - Septic shock KW - staphylococcal enterotoxin B KW - D-Galactosamine KW - J 02822:Biosynthesis and physicochemical properties KW - J 02855:Human Bacteriology: Others KW - V 22150:Animal models & experimentally-induced viral infections UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17490751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Increased+Sensitivity+to+Staphylococcal+Enterotoxin+B+following+Adenoviral+Infection&rft.au=Yarovinsky%2C+Timur+O%3BMohning%2C+Michael+P%3BBradford%2C+Mary+A%3BMonick%2C+Martha+M%3BHunninghake%2C+Gary+W&rft.aulast=Yarovinsky&rft.aufirst=Timur&rft.date=2005-06-01&rft.volume=73&rft.issue=6&rft.spage=3375&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Hypothermia; gamma -Interferon; Apoptosis; virulence factors; Animal models; Liver; Septic shock; D-Galactosamine; staphylococcal enterotoxin B; Adenovirus ER - TY - CPAPER T1 - Role of the xenobiotic receptor PXR in acetaminophen hepatotoxicity AN - 40038246; 3929703 AU - Wolf, K K AU - Wood, S G AU - Walton-Strong, B W AU - Yasuda, K AU - Lan, L AU - Sinclair, PR AU - Wrighton, SA AU - Jeffery, E H AU - Evans, R M AU - Schuetz, E G Y1 - 2005/05/25/ PY - 2005 DA - 2005 May 25 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40038246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+the+xenobiotic+receptor+PXR+in+acetaminophen+hepatotoxicity&rft.au=Wolf%2C+K+K%3BWood%2C+S+G%3BWalton-Strong%2C+B+W%3BYasuda%2C+K%3BLan%2C+L%3BSinclair%2C+PR%3BWrighton%2C+SA%3BJeffery%2C+E+H%3BEvans%2C+R+M%3BSchuetz%2C+E+G&rft.aulast=Wolf&rft.aufirst=K&rft.date=2005-05-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Resont, VA 20190-5332, USA; phone: 703-438-3115; fax: 703-438-3113; URL: http://www.toxicology.org N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - High rates of adverse drug events in a highly computerized hospital. AN - 67852297; 15911723 AB - Numerous studies have shown that specific computerized interventions may reduce medication errors, but few have examined adverse drug events (ADEs) across all stages of the computerized medication process. We describe the frequency and type of inpatient ADEs that occurred following the adoption of multiple computerized medication ordering and administration systems, including computerized physician order entry (CPOE). Using explicit standardized criteria, pharmacists classified inpatient ADEs from prospective daily reviews of electronic medical records from a random sample of all admissions during a 20-week period at a Veterans Administration hospital. We analyzed ADEs that necessitated a changed treatment plan. Among 937 hospital admissions, 483 clinically significant inpatient ADEs were identified, accounting for 52 ADEs per 100 admissions and an incidence density of 70 ADEs per 1000 patient-days. One quarter of the hospitalizations had at least 1 ADE. Of all ADEs, 9% resulted in serious harm, 22% in additional monitoring and interventions, 32% in interventions alone, and 11% in monitoring alone; 27% should have resulted in additional interventions or monitoring. Medication errors contributed to 27% of these ADEs. Errors associated with ADEs occurred in the following stages: 61% ordering, 25% monitoring, 13% administration, 1% dispensing, and 0% transcription. The medical record reflected recognition of 76% of the ADEs. High rates of ADEs may continue to occur after implementation of CPOE and related computerized medication systems that lack decision support for drug selection, dosing, and monitoring. JF - Archives of internal medicine AU - Nebeker, Jonathan R AU - Hoffman, Jennifer M AU - Weir, Charlene R AU - Bennett, Charles L AU - Hurdle, John F AD - Veterans Administration Salt Lake City Health Care System, Geriatric Research, Education, and Clinical Center, Salt Lake City, Utah, USA. Jonathan.Nebeker@hsc.utah.edu Y1 - 2005/05/23/ PY - 2005 DA - 2005 May 23 SP - 1111 EP - 1116 VL - 165 IS - 10 SN - 0003-9926, 0003-9926 KW - Abridged Index Medicus KW - Index Medicus KW - Clinical Pharmacy Information Systems KW - Random Allocation KW - Humans KW - Retrospective Studies KW - Decision Support Systems, Clinical KW - Follow-Up Studies KW - Medication Systems, Hospital KW - Medical Records Systems, Computerized KW - Hospitals, University KW - Drug-Related Side Effects and Adverse Reactions KW - Medication Errors -- statistics & numerical data KW - Drug Therapy, Computer-Assisted UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67852297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=High+rates+of+adverse+drug+events+in+a+highly+computerized+hospital.&rft.au=Nebeker%2C+Jonathan+R%3BHoffman%2C+Jennifer+M%3BWeir%2C+Charlene+R%3BBennett%2C+Charles+L%3BHurdle%2C+John+F&rft.aulast=Nebeker&rft.aufirst=Jonathan&rft.date=2005-05-23&rft.volume=165&rft.issue=10&rft.spage=1111&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-21 N1 - Date created - 2005-05-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 2006 Jun 12;166(11):1235-6; author reply 1236 [16772256] Arch Intern Med. 2006 Jun 12;166(11):1234-5; author reply 1236 [16772255] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of murine macrophage TNF- alpha synthesis by Mycobacterium avium is modulated through complement-dependent interaction via complement receptors 3 and 4 in relation to M. avium glycopeptidolipid AN - 17545113; 6265669 AB - We studied whether complement receptor (CR) mediated Mycobacterium avium interaction modulated macrophage TNF- alpha expression. Compared to control conditions, infections performed with C3-depletion yielded significantly higher TNF- alpha levels. Blockage of the CR4 iC3b site yielded increases in TNF- alpha for all morphotypic variants of a virulent serovar-8 strain (smooth transparent (SmT), smooth opaque (SmO), serovar-specific glycopeptidolipid (ssGPL) deficient knockout mutant) whereas CR3 blockage increased TNF- alpha only for SmT and ssGPL-deficient strains. Thus, complement-mediated binding of M. avium to CR3 and CR4 was shown to modulate TNF- alpha expression. The differential activation of morphotypic and isogenic variants of a single strain provides an excellent model system to delineate signaling pathways. JF - FEMS Microbiology Letters AU - Irani, V R AU - Maslow, J N AD - Division of Infectious Diseases, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States, joel.maslow@med.va.gov Y1 - 2005/05/15/ PY - 2005 DA - 2005 May 15 SP - 221 EP - 228 VL - 246 IS - 2 SN - 0378-1097, 0378-1097 KW - mice KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Mycobacterium avium KW - Complement KW - Animal models KW - Infection KW - Tumor necrosis factor-a KW - Glycopeptidolipids KW - Tumor necrosis factor-^a KW - complement receptor 3 KW - Signal transduction KW - G 07240:Immunogenetics KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17545113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEMS+Microbiology+Letters&rft.atitle=Induction+of+murine+macrophage+TNF-+alpha+synthesis+by+Mycobacterium+avium+is+modulated+through+complement-dependent+interaction+via+complement+receptors+3+and+4+in+relation+to+M.+avium+glycopeptidolipid&rft.au=Irani%2C+V+R%3BMaslow%2C+J+N&rft.aulast=Irani&rft.aufirst=V&rft.date=2005-05-15&rft.volume=246&rft.issue=2&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=FEMS+Microbiology+Letters&rft.issn=03781097&rft_id=info:doi/10.1016%2Fj.femsle.2005.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium avium; Tumor necrosis factor-a; Glycopeptidolipids; Macrophages; Signal transduction; Animal models; Infection; Complement; complement receptor 3; Tumor necrosis factor-^a DO - http://dx.doi.org/10.1016/j.femsle.2005.04.008 ER - TY - JOUR T1 - Integrin alpha5/beta1 expression mediates HER-2 down-regulation in colon cancer cells. AN - 67800945; 15757908 AB - HER-2 is constitutively activated and overexpressed in many cancers, and its inhibition in colon cancer cells diminishes tumorigenicity and induces apoptosis. Little is known about the regulation of HER-2 signaling in colon cancer cells. Integrin alpha5/beta1 expression is frequently lost in colorectal cancer cells compared with normal intestinal epithelium, and colon cancer cells lacking integrin alpha5/beta1 expression utilize HER-2 signaling for proliferation and tumorigenicity. Re-expression of integrin alpha5/beta1 in colon cancer cells abrogated their tumorigenicity, but how this occurs is not well known. Stable expression of integrin alpha5/beta1 in colon cancer cells with little or no detectable integrin alpha5/beta1 protein expression resulted in the post-transcriptional down-regulation of HER-2 protein. Integrin alpha5/beta1 was found to interact with HER-2, and the cytoplasmic domain of integrin alpha5/beta1 was sufficient to mediate HER-2 down-regulation. Integrin alpha5/beta1-mediated down-regulation of HER-2 was the result of increased lysosomal targeting. The inhibition of HER-2 signaling represents a potential mechanism by which integrin alpha5/beta1 exerts its tumor suppressor-like activity in colon cancer cells. These results also suggest that a novel function for integrin alpha5/beta1 is the control of HER-2 expression. JF - The Journal of biological chemistry AU - Kuwada, Scott K AU - Kuang, Jinqiu AU - Li, Xiufen AD - Department of Medicine, Salt Lake City Veterans Administration Health Care System and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA. Y1 - 2005/05/13/ PY - 2005 DA - 2005 May 13 SP - 19027 EP - 19035 VL - 280 IS - 19 SN - 0021-9258, 0021-9258 KW - Integrin alpha5beta1 KW - 0 KW - RNA, Messenger KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Agar KW - 9002-18-0 KW - Receptor, ErbB-2 KW - EC 2.7.10.1 KW - Index Medicus KW - Immunoblotting KW - Blotting, Northern KW - Extracellular Matrix -- metabolism KW - Humans KW - Immunoprecipitation KW - Transcription, Genetic KW - Lysosomes -- metabolism KW - Caco-2 Cells KW - Cell Line, Tumor KW - Cell Proliferation KW - RNA Processing, Post-Transcriptional KW - Biotinylation KW - Mutagenesis, Site-Directed KW - RNA, Messenger -- metabolism KW - Phosphorylation KW - Agar -- chemistry KW - Transfection KW - Cytoplasm -- metabolism KW - Cell Membrane -- metabolism KW - Protein Structure, Tertiary KW - Time Factors KW - Green Fluorescent Proteins -- metabolism KW - Signal Transduction KW - Gene Expression Regulation, Neoplastic KW - Down-Regulation KW - Integrin alpha5beta1 -- biosynthesis KW - Colonic Neoplasms -- pathology KW - Receptor, ErbB-2 -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67800945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Integrin+alpha5%2Fbeta1+expression+mediates+HER-2+down-regulation+in+colon+cancer+cells.&rft.au=Kuwada%2C+Scott+K%3BKuang%2C+Jinqiu%3BLi%2C+Xiufen&rft.aulast=Kuwada&rft.aufirst=Scott&rft.date=2005-05-13&rft.volume=280&rft.issue=19&rft.spage=19027&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-12 N1 - Date created - 2005-05-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Biol Chem. 2005 Aug 5;280(31):28828 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mu-calpain is functionally required for alpha-processing of Alzheimer's beta-amyloid precursor protein. AN - 67706472; 15809056 AB - Alzheimer's beta-amyloid precursor protein (APP) is normally processed by an unidentified alpha-secretase. A unique feature of this protease is its high sensitivity to phorbol esters, yet the mechanism involved is unclear. We have previously reported that phorbol 12,13-dibutyrate (PDBu) activates calpain, a Ca2+-dependent protease, and PDBu-induced release of APPs (secreted APP) is sensitive to calpain inhibitors, suggesting that calpain is involved in APP alpha-processing. In the present study, we found that PDBu markedly promoted the expression of both mu- and m-calpains in cultured fibroblasts. Dose-response and time course studies revealed that mu-calpain was more sensitive to PDBu than m-calpain and the temporal course of the mu-calpain change coincides better with that of APPs release. Moreover, the stimulatory effect of PDBu on mu-calpain was selectively blocked by mu-calpain-specific siRNA (small interference RNA) and the blockage was accompanied by a concomitant decrease in APPs release. In contrast, m-calpain siRNA did not affect APPs release significantly. Measurement of amyloid beta protein (Abeta) release in the mu-calpain siRNA-treated cells indicated that Abeta40 and Abeta42 levels inversely changed in relation to APPs, and the changes in Abeta42 were more prominent than in Abeta40. Together, these data suggest that calpain, particularly mu-calpain, is a potential candidate for alpha-secretase in the regulated APP alpha-processing, and that changes in this protease can affect the outcome of the overall APP processing. JF - Biochemical and biophysical research communications AU - Chen, Ming AU - Fernandez, Hugo L AD - Neurobiology of Aging Research Laboratory, Bay Pines VA Medical Center, Bay Pines, FL 33744, USA. ming.chen@med.va.gov Y1 - 2005/05/13/ PY - 2005 DA - 2005 May 13 SP - 714 EP - 721 VL - 330 IS - 3 SN - 0006-291X, 0006-291X KW - Amyloid beta-Protein Precursor KW - 0 KW - Peptide Fragments KW - RNA, Small Interfering KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Calpain KW - EC 3.4.22.- KW - m-calpain KW - mu-calpain KW - Index Medicus KW - Peptide Fragments -- metabolism KW - Peptide Fragments -- chemistry KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Humans KW - RNA, Small Interfering -- genetics KW - RNA, Small Interfering -- metabolism KW - Cell Line KW - Phorbol 12,13-Dibutyrate -- pharmacology KW - Amyloid beta-Protein Precursor -- chemistry KW - Protein Processing, Post-Translational KW - Amyloid beta-Protein Precursor -- metabolism KW - Alzheimer Disease -- metabolism KW - Calpain -- genetics KW - Calpain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67706472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Mu-calpain+is+functionally+required+for+alpha-processing+of+Alzheimer%27s+beta-amyloid+precursor+protein.&rft.au=Chen%2C+Ming%3BFernandez%2C+Hugo+L&rft.aulast=Chen&rft.aufirst=Ming&rft.date=2005-05-13&rft.volume=330&rft.issue=3&rft.spage=714&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-14 N1 - Date created - 2005-04-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-term neuropsychological outcomes following mild traumatic brain injury. AN - 85382160; pmid-15892899 AB - Mild traumatic brain injury (MTBI) is common, yet few studies have examined neuropsychological outcomes more than 1 year postinjury. Studies of nonreferred individuals with MTBI or studies with appropriate control groups are lacking, but necessary to draw conclusions regarding natural recovery from MTBI. We examined the long-term neuropsychological outcomes of a self-reported MTBI an average of 8 years postinjury in a nonreferred community-dwelling sample of male veterans. This was a cross-sectional cohort study derived from the Vietnam Experience Study. Three groups matched on premorbid cognitive ability were examined, those who (1) had not been injured in a MVA nor had a head injury (Normal Control; n = 3214), (2) had been injured in a motor vehicle accident (MVA) but did not have a head injury (MVA Control; n = 539), and (3) had a head injury with altered consciousness (MTBI; n = 254). A MANOVA found no group differences on a standard neuropsychological test battery of 15 measures. Across 15 measures, the average neuropsychological effect size of MTBI compared with either control group was -.03. Subtle aspects of attention and working memory also were examined by comparing groups on Paced Auditory Serial Addition Test (PASAT) continuation rate and California Verbal Learning Test (CVLT) proactive interference (PI). Compared with normal controls, the MTBI group evidenced attention problems in their lower rate of continuation to completion on the PASAT (odds ratio = 1.32, CI = 1.0-1.73) and in excessive PI (odds ratio = 1.66, CI = 1.11-2.47). Unique to the MTBI group, PASAT continuation problems were associated with left-sided visual imperceptions and excessive PI was associated with impaired tandem gait. These results show that MTBI can have adverse long-term neuropsychological outcomes on subtle aspects of complex attention and working memory. JF - Journal of the International Neuropsychological Society : JINS AU - Vanderploeg, Rodney D AU - Curtiss, Glenn AU - Belanger, Heather G AD - Department of Mental Health and Behavioral Sciences, James A. Haley VAMC, Tampa, Florida 33612, USA. Rodney.Vanderploeg@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 228 EP - 236 VL - 11 IS - 3 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Brain Injuries: complications KW - *Cognition Disorders: diagnosis KW - *Cognition Disorders: etiology KW - Demography KW - Female KW - Humans KW - Male KW - Neuropsychological Tests KW - Severity of Illness Index KW - Time KW - Time Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85382160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Long-term+neuropsychological+outcomes+following+mild+traumatic+brain+injury.&rft.au=Vanderploeg%2C+Rodney+D%3BCurtiss%2C+Glenn%3BBelanger%2C+Heather+G&rft.aulast=Vanderploeg&rft.aufirst=Rodney&rft.date=2005-05-01&rft.volume=11&rft.issue=3&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Factors moderating neuropsychological outcomes following mild traumatic brain injury: a meta-analysis. AN - 85380638; pmid-15892898 AB - There continues to be debate about the long-term neuropsychological impact of mild traumatic brain injury (MTBI). A meta-analysis of the relevant literature was conducted to determine the impact of MTBI across nine cognitive domains. The analysis was based on 39 studies involving 1463 cases of MTBI and 1191 control cases. The overall effect of MTBI on neuropsychological functioning was moderate (d = .54). However, findings were moderated by cognitive domain, time since injury, patient characteristics, and sampling methods. Acute effects (less than 3 months postinjury) of MTBI were greatest for delayed memory and fluency (d = 1.03 and .89, respectively). In unselected or prospective samples, the overall analysis revealed no residual neuropsychological impairment by 3 months postinjury (d = .04). In contrast, clinic-based samples and samples including participants in litigation were associated with greater cognitive sequelae of MTBI (d = .74 and .78, respectively at 3 months or greater). Indeed, litigation was associated with stable or worsening of cognitive functioning over time. The implications and limitations of these findings are discussed. JF - Journal of the International Neuropsychological Society : JINS AU - Belanger, Heather G AU - Curtiss, Glenn AU - Demery, Jason A AU - Lebowitz, Brian K AU - Vanderploeg, Rodney D AD - James A. Haley Veterans' Hospital, Tampa, Florida 33612, USA. Heather.Belanger@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 215 EP - 227 VL - 11 IS - 3 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - *Brain Injuries: complications KW - *Cognition Disorders: diagnosis KW - *Cognition Disorders: etiology KW - Humans KW - Neuropsychological Tests KW - Severity of Illness Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85380638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Factors+moderating+neuropsychological+outcomes+following+mild+traumatic+brain+injury%3A+a+meta-analysis.&rft.au=Belanger%2C+Heather+G%3BCurtiss%2C+Glenn%3BDemery%2C+Jason+A%3BLebowitz%2C+Brian+K%3BVanderploeg%2C+Rodney+D&rft.aulast=Belanger&rft.aufirst=Heather&rft.date=2005-05-01&rft.volume=11&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Patterns of urges during early abstinence in alcohol-dependent subjects. AN - 68033951; 16019975 AB - Urges for alcohol can lead to relapse, but some alcoholics report few urges. We hypothesized that ecological momentary assessment techniques would reveal multiple urge patterns in newly-abstinent alcoholics. Forty-eight alcohol-dependent subjects used PDAs to assess urges to drink in abstinence. Mean and standard deviation of urges were used in cluster analysis, and cluster characteristics were compared. Four clusters were defined, the largest cluster including 29 subjects with low mean urge and low variability. Clusters differed in negative affect and anger but not in abstinence rates. Four distinct urge patterns during abstinence were identified, and 60% of abstinent, alcohol-dependent subjects reported low, stable urge levels. JF - The American journal on addictions AU - Krahn, Dean D AU - Bohn, Michael J AU - Henk, Henry J AU - Grossman, Jennifer L AU - Gosnell, Blake AD - University of Wisconsin, Department of Psychiatry, Madison, WI 53705, USA. dean.krahn@med.va.gov PY - 2005 SP - 248 EP - 255 VL - 14 IS - 3 SN - 1055-0496, 1055-0496 KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Alcohol Drinking -- prevention & control KW - Affect KW - Computers, Handheld KW - Wisconsin KW - Cluster Analysis KW - Secondary Prevention KW - Male KW - Substance Abuse Treatment Centers KW - Motivation KW - Temperance KW - Alcohol-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68033951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Patterns+of+urges+during+early+abstinence+in+alcohol-dependent+subjects.&rft.au=Krahn%2C+Dean+D%3BBohn%2C+Michael+J%3BHenk%2C+Henry+J%3BGrossman%2C+Jennifer+L%3BGosnell%2C+Blake&rft.aulast=Krahn&rft.aufirst=Dean&rft.date=2005-05-01&rft.volume=14&rft.issue=3&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-30 N1 - Date created - 2005-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Learning and memory in aging combat veterans with PTSD. AN - 67944295; 15962694 AB - The California Verbal Learning Test (CVLT) was administered to examine learning and memory performance in aging combat veterans with (n = 30) and without PTSD (n = 20), and veterans unexposed to combat (n = 15). Combat veterans with PTSD (PTSD+) showed many impairments compared to non-exposed veterans, but only long-delay free recall consistently discriminated the PTSD+ group from combat-exposed subjects without PTSD (PTSD-), when data were corrected for subscale scores on the WAIS (Vocabulary, Block Design). Alterations in total learning were associated with PTSD when controlling for substance abuse and depression. Two contrast measures, proactive interference and recognition hits, distinguished combat from noncombat veterans, and may be related to trauma exposure. Impairments in total learning are similar to what has been observed in Holocaust survivors. However, increased severity of rapid forgetting may be a specific alteration in older combat veterans, likely reflecting aspects of both combat exposure and aging. JF - Journal of clinical and experimental neuropsychology AU - Yehuda, Rachel AU - Golier, Julia A AU - Tischler, Lisa AU - Stavitsky, Karina AU - Harvey, Philip D AD - Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of MedicineNew York, NY, USA. Rachel.Yehuda@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 504 EP - 515 VL - 27 IS - 4 SN - 1380-3395, 1380-3395 KW - Index Medicus KW - Substance-Related Disorders -- physiopathology KW - Neuropsychological Tests -- statistics & numerical data KW - Demography KW - Analysis of Variance KW - Humans KW - Attention -- physiology KW - Aged KW - Middle Aged KW - Language Tests -- statistics & numerical data KW - Male KW - Veterans KW - Aging -- physiology KW - Memory -- physiology KW - Verbal Learning -- physiology KW - Stress Disorders, Post-Traumatic -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67944295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+and+experimental+neuropsychology&rft.atitle=Learning+and+memory+in+aging+combat+veterans+with+PTSD.&rft.au=Yehuda%2C+Rachel%3BGolier%2C+Julia+A%3BTischler%2C+Lisa%3BStavitsky%2C+Karina%3BHarvey%2C+Philip+D&rft.aulast=Yehuda&rft.aufirst=Rachel&rft.date=2005-05-01&rft.volume=27&rft.issue=4&rft.spage=504&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+and+experimental+neuropsychology&rft.issn=13803395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-29 N1 - Date created - 2005-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effectiveness of payment for reduced carbon monoxide levels and noncontingent payments on smoking behaviors in cocaine-abusing outpatients wearing nicotine or placebo patches. AN - 67913809; 15943543 AB - In a 2-week intervention to reduce cigarette smoking among outpatients in treatment for cocaine addiction, 20 subjects were randomly assigned to a contingent group, receiving monetary vouchers for breath samples with carbon monoxide (CO) levels of 8 ppm or less, or to a noncontingent group, receiving vouchers regardless of CO level. Subjects wore either nicotine or placebo patches in a randomized crossover design. Contingent subjects had significantly lower CO levels and met the 8 ppm target significantly more often than did noncontingent subjects; however, number of cigarettes reported smoked did not differ between groups. Use of nicotine patches resulted in CO levels significantly lower than did use of placebo patches, but levels still exceeded 8 ppm regardless of type of patch. Because contingent reward helped cocaine-dependent smokers achieve nonsmoking CO targets, behavioral antismoking interventions merit continued study in similar populations. Copyright 2005 APA, all rights reserved. JF - Experimental and clinical psychopharmacology AU - Wiseman, Eve J AU - Williams, D K AU - McMillan, D E AD - Mental Health Service Line, Central Arkansas Veterans Healthcare System, Little Rock, 72205, USA. Eve.Wiseman@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 102 EP - 110 VL - 13 IS - 2 SN - 1064-1297, 1064-1297 KW - Nicotinic Agonists KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Carbon Monoxide KW - 7U1EE4V452 KW - Index Medicus KW - Administration, Cutaneous KW - Motivation KW - Humans KW - Adult KW - Treatment Outcome KW - Cross-Over Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Carbon Monoxide -- blood KW - Smoking -- therapy KW - Nicotine -- therapeutic use KW - Nicotinic Agonists -- therapeutic use KW - Smoking -- blood KW - Smoking Cessation -- economics KW - Cocaine-Related Disorders -- economics KW - Smoking Cessation -- methods KW - Nicotine -- administration & dosage KW - Cocaine-Related Disorders -- therapy KW - Cocaine-Related Disorders -- blood KW - Smoking -- economics KW - Nicotinic Agonists -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67913809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Effectiveness+of+payment+for+reduced+carbon+monoxide+levels+and+noncontingent+payments+on+smoking+behaviors+in+cocaine-abusing+outpatients+wearing+nicotine+or+placebo+patches.&rft.au=Wiseman%2C+Eve+J%3BWilliams%2C+D+K%3BMcMillan%2C+D+E&rft.aulast=Wiseman&rft.aufirst=Eve&rft.date=2005-05-01&rft.volume=13&rft.issue=2&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-08 N1 - Date created - 2005-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Emerging chemotherapeutic strategies for Huntington's disease. AN - 67903168; 15934871 AB - Huntington's disease (HD) is a progressive and fatal neurological disorder caused by an expanded CAG repeat in the gene coding for the protein, huntingtin. There is no clinically proven treatment for HD. Although the exact cause of neuronal death in HD remains unknown, it has been postulated that the abnormal aggregation of the mutant huntingtin protein may cause toxic effects in neurons, leading to a cascade of pathogenic mechanisms associated with transcriptional dysfunction, oxidative stress, mitochondrial alterations, apoptosis, bioenergetic defects and subsequent excitotoxicity. Understanding how these processes interrelate has become important in identifying a pharmacotherapy in HD and in the design of clinical trials. A number of drug compounds that separately target these mechanisms have significantly improved the clinical and neuropathological phenotype of HD transgenic mice and, as such, are immediate candidates for human clinical trials in HD patients. These compounds are discussed herein. JF - Expert opinion on emerging drugs AU - Ryu, Hoon AU - Ferrante, Robert J AD - Boston University School of Medicine, Edith Nourse Rogers Veterans Administration Medical Center, Bedford, Massachusetts 01730, USA. Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 345 EP - 363 VL - 10 IS - 2 KW - Antineoplastic Agents KW - 0 KW - Coenzymes KW - Drugs, Investigational KW - Ubiquinone KW - 1339-63-5 KW - coenzyme Q10 KW - EJ27X76M46 KW - Index Medicus KW - Animals KW - Humans KW - Ubiquinone -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- chemistry KW - Ubiquinone -- chemistry KW - Ubiquinone -- analogs & derivatives KW - Clinical Trials as Topic -- statistics & numerical data KW - Drugs, Investigational -- therapeutic use KW - Huntington Disease -- metabolism KW - Drug Industry -- trends KW - Drugs, Investigational -- chemistry KW - Huntington Disease -- drug therapy KW - Huntington Disease -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67903168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+emerging+drugs&rft.atitle=Emerging+chemotherapeutic+strategies+for+Huntington%27s+disease.&rft.au=Ryu%2C+Hoon%3BFerrante%2C+Robert+J&rft.aulast=Ryu&rft.aufirst=Hoon&rft.date=2005-05-01&rft.volume=10&rft.issue=2&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+emerging+drugs&rft.issn=1744-7623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-14 N1 - Date created - 2005-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Withdrawal, tolerance, and sensitization to dopamine mediated interoceptive cues in rats trained on a three-lever drug-discrimination task. AN - 67830814; 15894057 AB - In the present experiment rats were trained on a three-lever, drug-discrimination task to discriminate the cues associated with 0.30 mg/kg of the indirect dopamine (DA) agonist, amphetamine (AMPH), saline (SAL), and 0.03 mg/kg of the DA, D2 receptor antagonist, haloperidol (HAL). Choice behavior determined from tests on 0.30 and 0.15 mg/kg AMPH, SAL 0.03 and 0.015 mg/kg HAL provided a behavioral baseline presumed to represent changes along a continuum of DA mediated, interoceptive cues. Results from separate groups tested on 0.30 and 0.15 mg/kg AMPH, SAL, 0.03 and 0.015 mg/kg HAL, 24 h post-treatment with an acute 7.5 mg/kg dose of AMPH, showed rapid tolerance and withdrawal to the AMPH cue and sensitization to the HAL cue. The same tests 24 h following treatment with 1.0 mg/kg HAL showed rapid tolerance to the HAL cue, sensitization to the AMPH cue, but not AMPH-like withdrawal cues. Analysis of the results showed that tolerance to the AMPH and HAL cues reflected neuroadaptive baseline shifts and not weaker cue properties. These findings are consistent with predictions from opponent process theory of motivation and provide an animal model to study the motivational consequences that aversive symptoms of AMPH withdrawal such as dysphoria and anhedonia can have on drug-taking behavior. JF - Pharmacology, biochemistry, and behavior AU - Barrett, Robert J AU - Caul, William F AU - Smith, Randy AD - Veterans Administration Medical Center, Departments of Psychology, Vanderbilt University, 1310 24th Avenue South, Nashville, TN 37212-2637, USA. robert.j.barrett@vanderbilt.edu Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 1 EP - 8 VL - 81 IS - 1 SN - 0091-3057, 0091-3057 KW - Dopamine Agonists KW - 0 KW - Dopamine Antagonists KW - Amphetamine KW - CK833KGX7E KW - Haloperidol KW - J6292F8L3D KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Psychomotor Performance -- drug effects KW - Dose-Response Relationship, Drug KW - Dopamine Agonists -- pharmacology KW - Dopamine Antagonists -- pharmacology KW - Haloperidol -- pharmacology KW - Amphetamine -- pharmacology KW - Male KW - Psychomotor Performance -- physiology KW - Discrimination Learning -- drug effects KW - Discrimination Learning -- physiology KW - Substance Withdrawal Syndrome -- physiopathology KW - Drug Tolerance -- physiology KW - Dopamine -- physiology KW - Cues UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67830814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Withdrawal%2C+tolerance%2C+and+sensitization+to+dopamine+mediated+interoceptive+cues+in+rats+trained+on+a+three-lever+drug-discrimination+task.&rft.au=Barrett%2C+Robert+J%3BCaul%2C+William+F%3BSmith%2C+Randy&rft.aulast=Barrett&rft.aufirst=Robert&rft.date=2005-05-01&rft.volume=81&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-30 N1 - Date created - 2005-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Randomized, controlled trial of a nonpharmacological intervention to improve abnormal sleep/wake patterns in nursing home residents. AN - 67805576; 15877555 AB - Abnormal sleep/wake patterns are common in nursing home residents. Lifestyle and environmental factors likely contribute to these poor sleep patterns. The objective of this study was to test a multidimensional, nonpharmacological intervention to improve abnormal sleep/wake patterns in nursing home residents. Randomized, controlled trial. Four nursing homes in the Los Angeles area. Residents were screened for excessive daytime sleeping (asleep > or = 15% of daytime observations) and nighttime sleep disruption (asleep < 80% of nighttime hours, according to wrist actigraphy). Four hundred ninety-two residents were screened; 339 had excessive daytime sleeping. Of these, 133 had nighttime sleep disruption and consented to participate; 120 completed baseline assessments, and 118 (77% female, mean age 86.9, 90% non-Hispanic white) were randomized to intervention versus usual care. Five consecutive days and nights of efforts to decrease daytime in-bed time, 30 minutes or more of daily sunlight exposure, increased physical activity, structured bedtime routine, and efforts to decrease nighttime noise and light. Seventy-two consecutive hours of wrist actigraphy (nighttime sleep) and structured behavioral observations (daytime sleep and participation in social and physical activities and social conversation) at baseline and repeated at follow-up while the intervention or usual care condition was in place. The only effect on nighttime sleep was a modest decrease in mean duration of nighttime awakenings in intervention participants (10.6 minutes at baseline, 9.8 minutes at follow-up) versus an increase in controls (9.8 minutes at baseline, 13.8 minutes at follow-up) (F=4.27, P=.04). There were no significant effects on percentage of nighttime sleep or number of nighttime awakenings. There was a significant decrease in daytime sleeping in intervention participants (32% of daytime observations asleep at baseline, 21% at follow-up), with no change in controls (32% at baseline, 30% at follow-up; F=20.68, P<.001). Intervention participants had increased participation in social (F=22.42, P<.001) and physical (F=12.65, P=.001) activities and social conversation (F=5.04, P=.03). A multidimensional, nonpharmacological intervention into lifestyle and environmental factors that likely contribute to abnormal sleep/wake patterns in nursing home residents resulted in decreased daytime sleeping and increased participation in social and physical activities and social conversation. Nonpharmacological interventions should be considered in the management of abnormal sleep/wake patterns in nursing home residents. The main effect may be a significant decrease in daytime sleeping, which may translate to an improvement in quality of life. JF - Journal of the American Geriatrics Society AU - Alessi, Cathy A AU - Martin, Jennifer L AU - Webber, Adam P AU - Cynthia Kim, E AU - Harker, Judith O AU - Josephson, Karen R AD - Geriatric Research, Education and Clinical Center; Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA. cathy.alessi@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 803 EP - 810 VL - 53 IS - 5 SN - 0002-8614, 0002-8614 KW - Index Medicus KW - Life Style KW - Aged, 80 and over KW - Humans KW - Interpersonal Relations KW - Treatment Outcome KW - Aged KW - Nursing Homes KW - Male KW - Female KW - Sleep Disorders, Circadian Rhythm -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67805576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Randomized%2C+controlled+trial+of+a+nonpharmacological+intervention+to+improve+abnormal+sleep%2Fwake+patterns+in+nursing+home+residents.&rft.au=Alessi%2C+Cathy+A%3BMartin%2C+Jennifer+L%3BWebber%2C+Adam+P%3BCynthia+Kim%2C+E%3BHarker%2C+Judith+O%3BJosephson%2C+Karen+R&rft.aulast=Alessi&rft.aufirst=Cathy&rft.date=2005-05-01&rft.volume=53&rft.issue=5&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-21 N1 - Date created - 2005-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evidence for PTZ-like cues as a function of time following treatment with chlordiazepoxide: implications for understanding tolerance and withdrawal. AN - 67800183; 15864069 AB - The present study used a two-lever, drug-discrimination procedure to train rats to discriminate between the cues associated with 5 mg/kg of the anxiolytic, chlordiazepoxide (CDP) and 15 mg/kg of the anxiogenic, pentylenetetrazol (PTZ), to investigate the relationship between withdrawal and acute tolerance. Training doses of the two drugs were chosen so that rats responded about equally on both levers when tested on saline (SAL). Following acquisition of the discrimination, rats were injected with 10 mg/kg CDP and tested for lever choice at various intervals from 6 h to 192 h. These tests revealed that cues associated with CDP withdrawal lasted approximately three times longer than the cues associated with the drug's primary effects. At the shortest retest interval (6 h) after treatment with 10 mg/kg CDP, rats responded primarily on the CDP lever, followed by a shift to predominant responding on the PTZ lever at the 16 h and 24 h intervals before returning to predrug, baseline levels at the longer intervals (48-192 h). In order to investigate the relationship between tolerance and withdrawal to the cue properties of CDP, CDP dose-response curves were determined 24 h following treatment with SAL or 10 mg/kg CDP. Acute tolerance, as defined by a rightward, parallel shift in the dose-response function, was observed in the rats pretreated with CDP. Furthermore, it was evident that the baseline shift associated with CDP withdrawal, rather than a weaker drug cue, accounted for acute tolerance. The results from this study are relevant to evaluating the role positive and negative reinforcement play in motivating compulsive drug use. JF - Behavioural pharmacology AU - Barrett, R J AU - Smith, R L AD - Veterans Administration Medical Center, Departments of Psychology and Pharmacology, Vanderbilt University, Vanderbilt School of Medicine, Nashville, Tennessee 37212, USA. r2k2@comcast.net Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 147 EP - 153 VL - 16 IS - 3 SN - 0955-8810, 0955-8810 KW - Anti-Anxiety Agents KW - 0 KW - GABA Agonists KW - Chlordiazepoxide KW - 6RZ6XEZ3CR KW - Pentylenetetrazole KW - WM5Z385K7T KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Reinforcement Schedule KW - Motivation KW - Reinforcement (Psychology) KW - Male KW - Anti-Anxiety Agents -- pharmacology KW - Discrimination Learning KW - Chlordiazepoxide -- pharmacology KW - Substance Withdrawal Syndrome KW - GABA Agonists -- pharmacology KW - Pentylenetetrazole -- pharmacology KW - Anti-Anxiety Agents -- adverse effects KW - Chlordiazepoxide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67800183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+pharmacology&rft.atitle=Evidence+for+PTZ-like+cues+as+a+function+of+time+following+treatment+with+chlordiazepoxide%3A+implications+for+understanding+tolerance+and+withdrawal.&rft.au=Barrett%2C+R+J%3BSmith%2C+R+L&rft.aulast=Barrett&rft.aufirst=R&rft.date=2005-05-01&rft.volume=16&rft.issue=3&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Behavioural+pharmacology&rft.issn=09558810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-13 N1 - Date created - 2005-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans. AN - 67790859; 15855577 AB - Animal and in vitro studies indicate that a decrease in beta-cell insulin secretion, and thus a decrease in tonic alpha-cell inhibition by intraislet insulin, may be an important factor for the increase in glucagon secretion during hypoglycemia. However, in humans this role of decreased intraislet insulin is still unclear. We studied glucagon responses to hypoglycemia in 14 nondiabetic subjects on two separate occasions. On both occasions, insulin was infused from 0 to 120 min to induce hypoglycemia. On one occasion, somatostatin was infused from -60 to 60 min to suppress insulin secretion, so that the decrement in intraislet insulin during the final 60 min of hypoglycemia would be reduced. On the other occasion, subjects received an infusion of normal saline instead of the somatostatin. During the 2nd h of the insulin infusion, when somatostatin or saline was no longer being infused, plasma glucose ( approximately 2.6 mmol/l) and insulin levels ( approximately 570 pmol/l) were comparable in both sets of experiments (both P > 0.4). In the saline experiments, insulin secretion remained unchanged from baseline (-90 to -60 min) before insulin infusion and decreased from 1.20 +/- 0.12 to 0.16 +/- 0.04 pmol . kg(-1) . min(-1) during insulin infusion (P < 0.001). However, in the somatostatin experiments, insulin secretion decreased from 1.18 +/- 0.12 pmol . kg(-1) . min(-1) at baseline to 0.25 +/- 0.09 pmol . kg(-1) . min(-1) before insulin infusion so that it did not decrease further during insulin infusion (-0.12 +/- 0.10 pmol . kg(-1) . min(-1), P = 0.26) indicating the complete lack of a decrement in intraislet insulin during hypoglycemia. This was associated with approximately 30% lower plasma glucagon concentrations (109 +/- 7 vs. 136 +/- 9 pg/ml, P < 0.006) and increments in plasma glucagon above baseline (41 +/- 8 vs. 67 +/- 11 pg/ml, P < 0.008) during the last 15 min of the hypoglycemic clamp. In contrast, increases in plasma growth hormone were approximately 70% greater during hypoglycemia after somatostatin infusion (P < 0.007), suggesting that to some extent the increases in plasma glucagon might have reflected a rebound in glucagon secretion. These results provide direct support for the intraislet insulin hypothesis in humans. However, the exact extent to which a decrement in intraislet insulin accounts for the glucagon responses to hypoglycemia remains to be established. JF - Diabetes care AU - Gosmanov, Niyaz R AU - Szoke, Ervin AU - Israelian, Zarmen AU - Smith, Tamar AU - Cryer, Philip E AU - Gerich, John E AU - Meyer, Christian AD - Carl T. Hayden VA Medical Center, 650 E. Indian School Road, Phoenix, AZ 85012, USA. christian.meyer@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 1124 EP - 1131 VL - 28 IS - 5 SN - 0149-5992, 0149-5992 KW - Blood Glucose KW - 0 KW - C-Peptide KW - Hypoglycemic Agents KW - Insulin KW - Human Growth Hormone KW - 12629-01-5 KW - Somatostatin KW - 51110-01-1 KW - Glucagon KW - 9007-92-5 KW - Hydrocortisone KW - WI4X0X7BPJ KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - C-Peptide -- blood KW - Humans KW - Adult KW - Somatostatin -- administration & dosage KW - Human Growth Hormone -- blood KW - Epinephrine -- blood KW - Male KW - Hydrocortisone -- blood KW - Female KW - Hypoglycemia -- metabolism KW - Glucagon -- secretion KW - Insulin -- blood KW - Hypoglycemic Agents -- administration & dosage KW - Insulin -- secretion KW - Insulin -- administration & dosage KW - Hypoglycemic Agents -- blood KW - Islets of Langerhans -- secretion KW - Hypoglycemia -- chemically induced KW - Glucagon -- blood KW - Islets of Langerhans -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67790859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+care&rft.atitle=Role+of+the+decrement+in+intraislet+insulin+for+the+glucagon+response+to+hypoglycemia+in+humans.&rft.au=Gosmanov%2C+Niyaz+R%3BSzoke%2C+Ervin%3BIsraelian%2C+Zarmen%3BSmith%2C+Tamar%3BCryer%2C+Philip+E%3BGerich%2C+John+E%3BMeyer%2C+Christian&rft.aulast=Gosmanov&rft.aufirst=Niyaz&rft.date=2005-05-01&rft.volume=28&rft.issue=5&rft.spage=1124&rft.isbn=&rft.btitle=&rft.title=Diabetes+care&rft.issn=01495992&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-05 N1 - Date created - 2005-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk-informed, performance-based inspections at medical facilities. AN - 67728336; 15824585 AB - During the past couple of years, radiation safety professionals have observed a significant change with regard to the inspection philosophy of regulators. The NRC and many Agreement State agencies have implemented a performance-based, risk-informed approach for inspecting medical Radiation Safety Programs. This new, less prescriptive approach originates from the necessity to produce safety benefits commensurate with their cost to the industry and still maintain health and safety performance. While compliance with regulatory requirements is important, regulatory agencies have been focusing on areas that provide greater safety benefit, such as protecting the radiation worker, members of the general public and the environment. This paper discusses simple and practical measures that may assist licensees in preparing for performance-based, risk informed inspections. JF - Health physics AU - Michel, René AU - Jacob, Ninni AU - Miller, Ken AU - Zorn, Michael AD - VA San Diego Healthcare System, San Diego, CA, USA. rene.michel@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - S69 EP - S72 VL - 88 IS - 5 Suppl SN - 0017-9078, 0017-9078 KW - Index Medicus KW - United States KW - Occupational Health -- legislation & jurisprudence KW - Health Facilities -- legislation & jurisprudence KW - Health Facilities -- standards KW - Medical Audit -- methods KW - Risk Assessment -- organization & administration KW - Management Audit -- methods KW - Radiation Protection -- legislation & jurisprudence KW - Employee Performance Appraisal -- methods KW - Risk Assessment -- methods KW - Management Audit -- organization & administration KW - Radiation Protection -- standards KW - Medical Audit -- organization & administration KW - Radiation Protection -- methods KW - Employee Performance Appraisal -- organization & administration KW - Safety Management -- methods KW - Health Facility Administration KW - Safety Management -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67728336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Risk-informed%2C+performance-based+inspections+at+medical+facilities.&rft.au=Michel%2C+Ren%C3%A9%3BJacob%2C+Ninni%3BMiller%2C+Ken%3BZorn%2C+Michael&rft.aulast=Michel&rft.aufirst=Ren%C3%A9&rft.date=2005-05-01&rft.volume=88&rft.issue=5+Suppl&rft.spage=S69&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-10 N1 - Date created - 2005-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Growth factors involved in prostate carcinogenesis. AN - 67516593; 15769631 AB - Prostate cancer is the most common non-skin cancer affecting men in United States and the second leading cause of death after lung cancer. The clinical course of patients after given diagnosis of prostate cancer is highly variable and the underlying reasons for such variability remain elusive. To better understand the pathophysiology of prostate cancer, there has been a push to elucidate the molecular mechanisms that mediate the development and progression of prostate cancer. Recent literature has pointed that a complex interplay between various cytokines, growth factors, and androgen receptors regulate the growth and functions of the prostate gland. Amongst the currently implicated anomalous pathways involved in prostate oncogenesis, the IGF-IGFBP axis has been demonstrated to play a very important role, although the precise molecular events regulated by IGF remain to be elucidated. The tumor promoting functions of VEGF has been defined in tumor angiogenesis and currently remains the central focus of anti-angiogenesis therapy in prostate cancer. Another key cytokine, TGF-beta has tumor-suppressor functions in normal prostate gland, but its pleiotropic functions in prostate cancer are influenced by the hormonal state of the disease. In partnership with other deregulated growth factor signaling, the TGF-beta cascade has also been implicated in the spread of prostate cancer. Lastly, members of the EGFR family, particularly the HER2 receptor, have also been recognized as crucial elements of aberrant signal transduction pathways, which induce activation of downstream signaling, involved in cellular proliferation, cell survival, and angiogenesis. The abnormal function of a number of growth factors in prostate cancer biology explains the heterogeneity of its histologic grade, mode of presentation and disease prognosis. At the same time, continued research in this field allows for the potential development of drug therapies against a diverse pool of cancer causing targets. JF - Frontiers in bioscience : a journal and virtual library AU - Kambhampati, Suman AU - Ray, Gibanananda AU - Sengupta, Krishanu AU - Reddy, Venkataprasanth P AU - Banerjee, Sushanta K AU - Van Veldhuizen, Peter J AD - Cancer Research Unit, Kansas City VA Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA. Suman.Kambhampati@med.va.gov Y1 - 2005/05/01/ PY - 2005 DA - 2005 May 01 SP - 1355 EP - 1367 VL - 10 SN - 1093-9946, 1093-9946 KW - Growth Substances KW - 0 KW - Insulin KW - Transforming Growth Factor beta KW - Vascular Endothelial Growth Factor A KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Transforming Growth Factor beta -- physiology KW - Insulin -- physiology KW - Humans KW - Carcinogenicity Tests KW - Vascular Endothelial Growth Factor A -- physiology KW - Receptor, Epidermal Growth Factor -- physiology KW - Male KW - Prostatic Neoplasms -- metabolism KW - Signal Transduction -- physiology KW - Growth Substances -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67516593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+bioscience+%3A+a+journal+and+virtual+library&rft.atitle=Growth+factors+involved+in+prostate+carcinogenesis.&rft.au=Kambhampati%2C+Suman%3BRay%2C+Gibanananda%3BSengupta%2C+Krishanu%3BReddy%2C+Venkataprasanth+P%3BBanerjee%2C+Sushanta+K%3BVan+Veldhuizen%2C+Peter+J&rft.aulast=Kambhampati&rft.aufirst=Suman&rft.date=2005-05-01&rft.volume=10&rft.issue=&rft.spage=1355&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+bioscience+%3A+a+journal+and+virtual+library&rft.issn=10939946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-18 N1 - Date created - 2005-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of stents and abciximab on survival from cardiogenic shock treated with percutaneous coronary intervention AN - 20814750; 10963440 AB - This retrospective observational review compares patient characteristics and in-hospital and long-term outcomes of cohorts of patients undergoing percutaneous coronary intervention (PCI) for cardiogenic shock complicating acute myocardial infarction (MI) prior to the use of stents (as well as glycoprotein IIb/IIIa inhibitor and dual-antiplatelet therapy) with PCI in the stent era. Cardiogenic shock remains the leading cause of hospital mortality from acute MI. This is a report of consecutive patients with cardiogenic shock complicating acute MI, without mechanical complication, referred for emergency catheterization to a single operator at two consecutive Veterans Affairs medical centers over a 15-year period (1988 to August 2003). PCI was attempted in all 93 cases: 44 consecutive patients in the prestent era and 49 consecutive patients in the stent era. Patients with comparable extent of coronary disease, more ST elevation myocardial infarction, multiple areas of infarction, and greater comorbidity underwent PCI in the stent era. Nevertheless, PCI in the stent era was associated with higher rates of acute success and improved in-hospital survival. Kaplan-Meier curves and log-rank testing showed highly significant improvement in overall survival (P < 0.0001). Logistic regression of in-hospital survival demonstrated that stent use (collinear with glycoprotein IIb/IIIa use and dual-antiplatelet therapy) was significantly associated with survival in a model adjusting for extent of coronary disease and comorbidities (P = 0.007). Stents and abciximab have been associated with improved acute angiographic and procedural success of PCI for cardiogenic shock, leading to improved survival. Published 2005 Wiley-Liss, Inc. JF - Catheterization and Cardiovascular Interventions AU - Huang, Raymond AU - Sacks, Jerome AU - Thai, Hoang AU - Goldman, Steven AU - Morrison, Douglass A AU - Barbiere, Charles AU - Ohm, Janet AD - Cardiovascular Disease Sections, Southern Arizona Veterans Affairs Healthcare System and University of Arizona Sarver Heart Center, Tucson, Arizona, douglass.morrison@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 25 EP - 33 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA, [mailto:info@wiley.com], [URL:http://www.wiley.com/WileyCDA/Brand/id-35.html] VL - 65 IS - 1 SN - 1522-1946, 1522-1946 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Mortality KW - Monoclonal antibodies KW - Survival KW - Myocardial infarction KW - Models KW - Catheterization KW - Shock KW - Implants KW - Regression analysis KW - Glycoproteins KW - Heart diseases KW - Hospitals KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20814750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Catheterization+and+Cardiovascular+Interventions&rft.atitle=Impact+of+stents+and+abciximab+on+survival+from+cardiogenic+shock+treated+with+percutaneous+coronary+intervention&rft.au=Huang%2C+Raymond%3BSacks%2C+Jerome%3BThai%2C+Hoang%3BGoldman%2C+Steven%3BMorrison%2C+Douglass+A%3BBarbiere%2C+Charles%3BOhm%2C+Janet&rft.aulast=Huang&rft.aufirst=Raymond&rft.date=2005-05-01&rft.volume=65&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Catheterization+and+Cardiovascular+Interventions&rft.issn=15221946&rft_id=info:doi/10.1002%2Fccd.20334 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Catheterization; Shock; Monoclonal antibodies; Implants; Regression analysis; Survival; Glycoproteins; Myocardial infarction; Models; Hospitals; Heart diseases DO - http://dx.doi.org/10.1002/ccd.20334 ER - TY - JOUR T1 - PROGRESS IN GERIATRICS: Legionnaires' Disease in Long-Term Care Facilities: Overview and Proposed Solutions AN - 19287047; 6252406 AB - Pneumonia is a leading cause of morbidity and mortality in nursing home patients. In acute care hospitals, there is considerable evidence to indicate that Legionnaires' disease is a significant cause of nosocomial pneumonia, the source of which is the potable water system. A relatively limited amount of data exists as to the role of Legionnaires' disease as a cause of pneumonia acquired in long-term care residents. Several lines of evidence suggest that Legionnaires' disease may be an important but underrecognized cause of pneumonia in long-term care residents. These include reports of outbreaks, prospective studies of community-acquired pneumonia that include nursing home patients, and prospective studies of individual long-term care facilities linking Legionnaires' disease to colonization of the potable water system with Legionella. Multiinstitutional studies combining environmental and clinical surveillance for Legionella are needed to further confirm the relationship between colonization of potable water and the occurrence of disease in the long-term care facilities. Until these studies are completed, it is recommended that individual facilities undertake annual sampling of the potable water system for Legionella, coupled with introduction of the rapid Legionella urinary antigen test should L. pneumophila serogroup 1 be found. JF - Journal of the American Geriatrics Society AU - Seenivasan, Meena H AU - Yu, Victor L AU - Muder, Robert R AD - Robert R. Muder, MD, Infectious Disease Section, VA Pittsburgh Healthcare System, University Drive C, Pittsburgh, PA 15240, Robert.Muder@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 875 EP - 880 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 53 IS - 5 SN - 0002-8614, 0002-8614 KW - Microbiology Abstracts B: Bacteriology KW - Mortality KW - Data processing KW - Morbidity KW - Colonization KW - Nursing KW - Reviews KW - Geriatrics KW - Sampling KW - Drinking water KW - Legionella KW - Pneumonia KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19287047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=PROGRESS+IN+GERIATRICS%3A+Legionnaires%27+Disease+in+Long-Term+Care+Facilities%3A+Overview+and+Proposed+Solutions&rft.au=Seenivasan%2C+Meena+H%3BYu%2C+Victor+L%3BMuder%2C+Robert+R&rft.aulast=Seenivasan&rft.aufirst=Meena&rft.date=2005-05-01&rft.volume=53&rft.issue=5&rft.spage=875&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2005.53270.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - SuppNotes - Tables, 2; references, 49. N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Colonization; Data processing; Reviews; Nursing; Geriatrics; Sampling; Drinking water; Morbidity; Pneumonia; Hospitals; Legionella DO - http://dx.doi.org/10.1111/j.1532-5415.2005.53270.x ER - TY - JOUR T1 - Influence of age on noise-and styrene-induced hearing loss in the Long-Evans rat AN - 17846388; 6241804 AB - This paper reviews different investigations carried out with Long-Evans rats on the influence of age on the ototoxicity induced by styrene and on the vulnerability to noise. The first part of this article is focused on the differences in auditory susceptibility to noise (92 or 97 dB octave band noise centered at 8 kHz, 6 h/day, 5 days/week, 4 weeks) and styrene (700 ppm, 6 h/d, 5 d/w, 4 w) between young (three and half months) and old (24 months) Long-Evans rats. Auditory evoked potential measures revealed that the old rats tend to be more sensitive than young rats to higher noise levels (97 dB), but equally vulnerable to moderate levels (92 dB). By contrast, the aged rats were virtually insensitive to 700 ppm styrene compared to the young animals. Two additional studies were performed controlling and examining the influence of body weight and post-natal age on the sensitivity to styrene. Rats of the same age (21 weeks) and but having different body weight ([not, vert, similar]310 g versus [not, vert, similar]410 g) did not show any difference of sensitivity to 700 ppm styrene, whereas 14-week-old rats with the same body weight as 21-week-old rats ([not, vert, similar]350 g) revealed increased sensitivity to styrene. These results show that weight does not play a key role in the sensitivity to styrene, and suggest a long period of increased sensitivity to styrene during the first months of life. JF - Environmental Toxicology and Pharmacology AU - Pouyatos, B AU - Campo, P AU - Lataye, R AD - Institut National de Recherche et de Securite, Ave de Bourgogne, BP 27, 54501 Vandoeuvre, France, benoit.pouyatos@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 561 EP - 570 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 19 IS - 3 SN - 1382-6689, 1382-6689 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Styrene KW - Noise KW - Hearing loss KW - Aging KW - Age KW - Weight KW - Auditory evoked potentials KW - Reviews KW - Ototoxicity KW - N3 11016:Auditory and vestibular systems (including echolocation) KW - X 24154:Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17846388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Pharmacology&rft.atitle=Influence+of+age+on+noise-and+styrene-induced+hearing+loss+in+the+Long-Evans+rat&rft.au=Pouyatos%2C+B%3BCampo%2C+P%3BLataye%2C+R&rft.aulast=Pouyatos&rft.aufirst=B&rft.date=2005-05-01&rft.volume=19&rft.issue=3&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Pharmacology&rft.issn=13826689&rft_id=info:doi/10.1016%2Fj.etap.2004.12.020 LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - The Ninth Meeting of the International Neurotoxicology Association (INA) N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Auditory evoked potentials; Styrene; Age; Ototoxicity; Reviews; Noise; Hearing loss DO - http://dx.doi.org/10.1016/j.etap.2004.12.020 ER - TY - JOUR T1 - Corynebacterium striatum: an underappreciated community and nosocomial pathogen AN - 17657824; 6446730 AB - Corynebacterium striatum (CS) is an underappreciated human pathogen that has been associated with serious infections in both immunocompetent and immunocompromised hosts. CS infections tend to be more frequent in males and major infection sites have included blood stream, lung, and central nervous system. Most are nosocomially acquired and there is a significant association with medical devices ranging from intravascular catheters to central nervous system drainage devices. Empiric therapy with vancomycin is advisable as susceptibility to other agents is variable. Treatment may also include removal of foreign material such as an intravascular catheter. The present review describes the wide spectrum of infections associated with CS and we add a unique case of CS pancreatic abscess where treatment included linezolid. JF - Journal of Infection AU - Lee, P P AU - Ferguson, DA AU - Sarubbi, F A AD - James H. Quillen VA Medical Center, Mountain Home, TN 37684, USA, felix.sarubbi@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 338 EP - 343 PB - W.B. Saunders Co. Ltd., 32 Jamestown Rd London NW1 7BY United Kingdom, [URL:http://www.harcourt-international.com] VL - 50 IS - 4 SN - 0163-4453, 0163-4453 KW - Microbiology Abstracts B: Bacteriology KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17657824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infection&rft.atitle=Corynebacterium+striatum%3A+an+underappreciated+community+and+nosocomial+pathogen&rft.au=Lee%2C+P+P%3BFerguson%2C+DA%3BSarubbi%2C+F+A&rft.aulast=Lee&rft.aufirst=P&rft.date=2005-05-01&rft.volume=50&rft.issue=4&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infection&rft.issn=01634453&rft_id=info:doi/10.1016%2Fj.jinf.2004.05.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-10-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1016/j.jinf.2004.05.005 ER - TY - JOUR T1 - Oxidative stress: a potential basis for potentiation of noise-induced hearing loss AN - 17523873; 6241821 AB - In the past two decades, researchers have determined that a broad range of environmental and occupational contaminants can interact with noise to enhance noise-induced hearing loss. This manuscript focuses upon the hypothesis that chemicals that promote oxidative stress might increase the risk of noise-induced hearing loss. Evidence is presented that confirms the role of oxidative stress in the production of hearing loss by both carbon monoxide and by acrylonitrile when noise is present at the time of chemical exposure. JF - Environmental Toxicology and Pharmacology AU - Fechter, L D AD - Research Service (151), Jerry L. Pettis Memorial Veterans Medical Center, 11201 Benton St, Loma Linda, CA 92357, USA, larry.fechter@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 543 EP - 546 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 19 IS - 3 SN - 1382-6689, 1382-6689 KW - acrylonitrile KW - oxidative stress KW - Pollution Abstracts; Health & Safety Science Abstracts; CSA Neurosciences Abstracts KW - Acrylonitrile KW - Auditory perception KW - Public health KW - Carbon monoxide KW - Oxidative stress KW - Occupational exposure KW - Noise levels KW - Hearing loss KW - Noise KW - Contaminants KW - P 7000:NOISE KW - H 1000:Occupational Safety and Health KW - N3 11016:Auditory and vestibular systems (including echolocation) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17523873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Pharmacology&rft.atitle=Oxidative+stress%3A+a+potential+basis+for+potentiation+of+noise-induced+hearing+loss&rft.au=Fechter%2C+L+D&rft.aulast=Fechter&rft.aufirst=L&rft.date=2005-05-01&rft.volume=19&rft.issue=3&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Pharmacology&rft.issn=13826689&rft_id=info:doi/10.1016%2Fj.etap.2004.12.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - The Ninth Meeting of the International Neurotoxicology Association (INA) N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hearing loss; Occupational exposure; Public health; Noise levels; Carbon monoxide; Contaminants; Noise; Auditory perception; Oxidative stress; Acrylonitrile DO - http://dx.doi.org/10.1016/j.etap.2004.12.017 ER - TY - JOUR T1 - Onset of Overweight during Childhood and Adolescence in Relation to Race and Sex AN - 17337751; 6275212 AB - Overweight [body mass index (BMI) percentile greater than or equal to 95th] in children has become a major public health problem. The age when overweight begins and how it progresses are mostly unknown. Such information would be important for the optimal timing of prevention. We conducted a survival analysis on time to overweight and compared survival curves by race and sex. Data from a cohort of 924 children recruited from schools in Indianapolis, IN, were analyzed. Blacks were at greater risk for becoming overweight than whites. Similar findings were obtained when at risk of overweight (BMI percentile greater than or equal to 85th and <95th) and overweight were considered as a single category. Twenty-five percent of blacks were overweight or at risk of overweight at or before age 7 yr, whereas it was age 11 yr in white females and age 10 yr in white males when 25% became overweight or were at risk of becoming overweight. The overall overweight-free survival curve for black females was significantly different from that for white females (P < 0.001), and black males were significantly different from white males (P = 0.04). There was no sex difference. The time to overweight during childhood and adolescence varies by race, indicating the need for race-specific timing of interventions. JF - Journal of Clinical Endocrinology and Metabolism AU - Saha, Chandan AU - Eckert, George J AU - Pratt, JHoward AU - Shankar, RRavi AD - Departments of Medicine (C.S., G.J.E., J.H.P.) and Pediatrics (R.R.S.), Indiana University, Purdue University at Indianapolis, and the Richard L. Roudebush Veterans Administration Medical Center (J.H.P.), Indianapolis, Indiana 46202 Y1 - 2005/05/01/ PY - 2005 DA - 2005 May 01 SP - 2648 EP - 2652 PB - Endocrine Society, 4350 East West Highway Suite 500 Bethesda MD 20814-4426 USA, [mailto:societyservices@endo-society.org], [URL:http://www.endo-society.org/] VL - 90 IS - 5 SN - 0021-972X, 0021-972X KW - Physical Education Index KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17337751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.atitle=Onset+of+Overweight+during+Childhood+and+Adolescence+in+Relation+to+Race+and+Sex&rft.au=Saha%2C+Chandan%3BEckert%2C+George+J%3BPratt%2C+JHoward%3BShankar%2C+RRavi&rft.aulast=Saha&rft.aufirst=Chandan&rft.date=2005-05-01&rft.volume=90&rft.issue=5&rft.spage=2648&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Psychiatric barriers to readiness for treatment for hepatitis C Virus (HCV) infection among injection drug users: clinical experience of an addiction psychiatrist in the HIV-HCV coinfection clinic of a public health hospital. AN - 67513127; 15768337 AB - Among injection drug users, psychological and psychiatric barriers to readiness for treatment for hepatitis C virus (HCV) infection include mood and anxiety disorders, cognitive deficits, temperament disorders, and personality vulnerabilities, as well as ongoing drug use. Many aspects of these barriers can be overcome with direct treatment or social support. To establish effective treatment for HCV infection in this population of patients, it is essential that the patient and providers develop a rapport that allows for active communication. It is also important that the patient make an effort to adhere to the treatment requirements and that the patient receive the appropriate evaluation and management of treatable barriers. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Scheft, Harriet AU - Fontenette, Dominique C AD - Lemuel Shattuck Hospital, Massachusetts Department of Public Health, Jamaica Plain, MA, USA. harriet.scheft@med.va.gov Y1 - 2005/04/15/ PY - 2005 DA - 2005 Apr 15 SP - S292 EP - S296 VL - 40 Suppl 5 KW - Index Medicus KW - Anxiety Disorders -- psychology KW - Humans KW - Patient Compliance -- psychology KW - Mood Disorders -- complications KW - Personality KW - Substance Abuse, Intravenous -- therapy KW - Substance-Related Disorders -- psychology KW - Anxiety Disorders -- complications KW - Substance-Related Disorders -- therapy KW - Hospitals, Public KW - HIV Infections -- complications KW - Adult KW - Temperament KW - Substance-Related Disorders -- complications KW - Substance Abuse, Intravenous -- complications KW - Psychiatry KW - Physician-Patient Relations KW - Cognition Disorders -- complications KW - Cognition Disorders -- psychology KW - Female KW - Mood Disorders -- psychology KW - Substance Abuse, Intravenous -- psychology KW - Hepatitis C -- therapy KW - Mental Disorders -- therapy KW - Hepatitis C -- complications KW - Mental Disorders -- psychology KW - Patient Selection KW - Hepatitis C -- psychology KW - Mental Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67513127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Psychiatric+barriers+to+readiness+for+treatment+for+hepatitis+C+Virus+%28HCV%29+infection+among+injection+drug+users%3A+clinical+experience+of+an+addiction+psychiatrist+in+the+HIV-HCV+coinfection+clinic+of+a+public+health+hospital.&rft.au=Scheft%2C+Harriet%3BFontenette%2C+Dominique+C&rft.aulast=Scheft&rft.aufirst=Harriet&rft.date=2005-04-15&rft.volume=40+Suppl+5&rft.issue=&rft.spage=S292&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-06 N1 - Date created - 2005-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effect of hearing aids and frequency modulation technology on results from the communication profile for the hearing impaired. AN - 85387356; pmid-16050335 AB - Hearing impairment has been associated with decline in psychosocial function. Previous investigations have reported that the utilization of hearing aids can ameliorate these reductions in psychosocial function. To date, few investigations have examined the effects of frequency modulation technology on hearing handicap, adjustment to hearing loss, and communicative strategies. The purpose of this investigation was to examine these effects and to compare them to the benefits obtained when using hearing aids alone. Subjects ranged in age from 34 to 81 years and had mean pure-tone thresholds consistent with a bilateral moderate to severe sloping sensorineural hearing loss. All subjects wore hearing aids only and hearing aids plus FM system in a randomized fashion. The Communication Profile for the Hearing Impaired (CPHI) was administered prior to fitting the study devices and once a month for three months in each of the two conditions. A statistically significant difference between device conditions was obtained for the Importance of Communication in Work Situations subscale. Additionally, statistically significant differences over time were noted in several CPHI subscales. Despite statistical significance, none of these results were clinically significant. The implications of these results will be discussed. JF - Journal of the American Academy of Audiology AU - Lewis, M Samantha AU - Valente, Michael AU - Horn, Jane Enrietto AU - Crandell, Carl AD - University of Florida, National Center for Rehabilitative Auditory Research, Portland VA Medical Center, USA. Michele.Lewis3@med.va.gov Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - 250 EP - 261 VL - 16 IS - 4 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Aged, 80 and over KW - Analysis of Variance KW - Auditory Threshold KW - *Communication KW - Ear, Middle KW - Female KW - *Hearing Aids KW - *Hearing Impaired Persons: rehabilitation KW - Humans KW - Male KW - Rehabilitation of Hearing Impaired KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85387356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=The+effect+of+hearing+aids+and+frequency+modulation+technology+on+results+from+the+communication+profile+for+the+hearing+impaired.&rft.au=Lewis%2C+M+Samantha%3BValente%2C+Michael%3BHorn%2C+Jane+Enrietto%3BCrandell%2C+Carl&rft.aulast=Lewis&rft.aufirst=M&rft.date=2005-04-01&rft.volume=16&rft.issue=4&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Dysplasia and risk of further neoplastic progression in a regional Veterans Administration Barrett's cohort. AN - 85380904; pmid-15784018 AB - No published data are available on the risk of further neoplastic progression in Barrett's patients stratified by baseline dysplasia status. Our aims were to estimate and compare the risk of progression to high-grade dysplasia or cancer in groups of Barrett's patients stratified by baseline dysplasia status.Consecutive Barrett's cases from 1988-2002 were identified via pathology databases in a regional VA health-care system and medical record data were abstracted. The risk of progression to high-grade dysplasia or cancer was measured and compared in cases with versus without low-grade dysplasia within 1 yr of index endoscopy using survival analysis.A total of 575 Barrett's cases had 2,775 patient-years of follow-up. There were 13 incident cases of high-grade dysplasia and two of cancer. The crude rate of high-grade dysplasia or cancer was 1 of 78 patient-years for those with baseline dysplasia versus 1 of 278 patient-years for those without (p= 0.001). One case of high-grade dysplasia in each group underwent successful therapy. One incident cancer case underwent successful resection and the other was unresectable. Two cases with high-grade dysplasia later developed cancer, one died postoperatively, the other was unresectable. When these two cases were included (total of four cancers), the crude rate of cancer was 1 of 274 patient-years for those with baseline dysplasia versus 1 of 1,114 patient-years for those without.In a large cohort study of Barrett's, incident malignancy was uncommon. The rate of progression to high-grade dysplasia or cancer was significantly higher in those with baseline low-grade dysplasia. These data may warrant reevaluation of current Barrett's surveillance strategies. JF - The American journal of gastroenterology AU - Dulai, Gareth S AU - Shekelle, Paul G AU - Jensen, Dennis M AU - Spiegel, Brennan M R AU - Chen, Jaime AU - Oh, David AU - Kahn, Katherine L AD - Greater Los Angeles Veterans Administration Healthcare System, Department of Medicine, Division of Gastroenterology, UCLA School of Medicine, Los Angeles, CA 90073, USA. Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - 775 EP - 783 VL - 100 IS - 4 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - *Adenocarcinoma: epidemiology KW - Adenocarcinoma: pathology KW - Aged KW - *Barrett Esophagus: epidemiology KW - Barrett Esophagus: pathology KW - Biopsy KW - California: epidemiology KW - *Cell Transformation, Neoplastic: pathology KW - Cohort Studies KW - Cross-Sectional Studies KW - Data Collection: statistics & numerical data KW - Delivery of Health Care, Integrated: statistics & numerical data KW - Disease Progression KW - *Esophageal Neoplasms: epidemiology KW - Esophageal Neoplasms: pathology KW - Esophagoscopy KW - Esophagus: pathology KW - Follow-Up Studies KW - Hospitals, Veterans: statistics & numerical data KW - Humans KW - Incidence KW - Male KW - Medical Records Systems, Computerized: statistics & numerical data KW - Metaplasia KW - Middle Aged KW - Population Surveillance KW - *Precancerous Conditions: epidemiology KW - Precancerous Conditions: pathology KW - Risk Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85380904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Dysplasia+and+risk+of+further+neoplastic+progression+in+a+regional+Veterans+Administration+Barrett%27s+cohort.&rft.au=Dulai%2C+Gareth+S%3BShekelle%2C+Paul+G%3BJensen%2C+Dennis+M%3BSpiegel%2C+Brennan+M+R%3BChen%2C+Jaime%3BOh%2C+David%3BKahn%2C+Katherine+L&rft.aulast=Dulai&rft.aufirst=Gareth&rft.date=2005-04-01&rft.volume=100&rft.issue=4&rft.spage=775&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Reduced CFTR function and the pathobiology of idiopathic pancreatitis. AN - 85379772; pmid-15758663 AB - Idiopathic chronic pancreatitis (ICP) is the leading cause of chronic pancreatitis in children and nonalcoholic adults. The risk of developing ICP is increased in individuals who have mutations of the cystic fibrosis gene (CFTR) and of a trypsin inhibitor gene (PSTI). In studies from the United States and France, the risk of ICP is increased about 40-fold by having two abnormal copies of the CFTR gene, about 14-fold by having the N34S PSTI mutation, and about 500-fold by having both. When ICP patients have two abnormal copies of the CFTR gene, there is also evidence of reduced residual CFTR protein function in extrapancreatic tissues based on clinical findings and nasal ion transport responses. Thus, pancreatitis risk is highest in individuals who have abnormalities in both the pancreatic ducts (CFTR) and acini (PSTI). These findings indicate that PSTI is a modifier gene for CFTR-related ICP and have implications for the diagnosis and pathogenesis of pancreatitis. JF - Journal of clinical gastroenterology AU - Cohn, Jonathan A AD - Veterans Administration and Duke University Medical Centers, Durham, NC 27710, USA. cohn0001@mc.duke.edu Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - S70 EP - S77 VL - 39 IS - 4 Suppl 2 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Child KW - Chronic Disease KW - Cystic Fibrosis: genetics KW - *Cystic Fibrosis Transmembrane Conductance Regulator: genetics KW - Genotype KW - Humans KW - Mutation KW - Pancreatitis: classification KW - *Pancreatitis: genetics KW - Prevalence KW - Trypsin Inhibitors: genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85379772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Reduced+CFTR+function+and+the+pathobiology+of+idiopathic+pancreatitis.&rft.au=Cohn%2C+Jonathan+A&rft.aulast=Cohn&rft.aufirst=Jonathan&rft.date=2005-04-01&rft.volume=39&rft.issue=4+Suppl+2&rft.spage=S70&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Portal hypertension: from bedside to bench. AN - 85378717; pmid-15758647 AB - The initial factor leading to portal hypertension is an increase in hepatic resistance. Later, an increase in portal blood flow contributes to maintain and exacerbate portal hypertension despite the development of portosystemic collaterals. The critical step in the development and acceptance of these concepts, which proved crucial for the management of patients with portal hypertension, was the development of animal models. These allowed the full characterization of the profound hemodynamic abnormalities in the systemic and splanchnic circulation associated with portal hypertension, and the elucidation of the molecular mechanisms implicated in these disturbances. This review traces how seminal clinical observations in the 1950s raised meaningful questions that were subsequently answered at the bench, leading to our current understanding of the pathophysiology of portal hypertension and of the pathogenesis of severe complications of cirrhosis, such as variceal bleeding or ascites. JF - Journal of clinical gastroenterology AU - Groszmann, Roberto J AU - Abraldes, Juan G AD - Veterans Administration Medical Center, West Haven, CT 06516, USA. roberto.groszmann@yale.edu Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - S125 EP - S130 VL - 39 IS - 4 Suppl 2 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Hemodynamics: physiology KW - Humans KW - *Hypertension, Portal: etiology KW - Hypertension, Portal: physiopathology KW - Liver Circulation: physiology KW - Liver Cirrhosis: physiopathology KW - Nitric Oxide: physiology KW - Portal System: physiology KW - Splanchnic Circulation: physiology KW - Vascular Resistance: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85378717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Portal+hypertension%3A+from+bedside+to+bench.&rft.au=Groszmann%2C+Roberto+J%3BAbraldes%2C+Juan+G&rft.aulast=Groszmann&rft.aufirst=Roberto&rft.date=2005-04-01&rft.volume=39&rft.issue=4+Suppl+2&rft.spage=S125&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Colchicine treatment of alcoholic cirrhosis: a randomized, placebo-controlled clinical trial of patient survival. AN - 67728831; 15825072 AB - Colchicine improved survival and reversed cirrhosis in several small clinical trials. We compared the efficacy and safety of long-term colchicine, as compared with placebo, in patients with advanced alcoholic cirrhosis. Five hundred forty-nine patients with advanced (Pugh B or C) alcoholic cirrhosis were randomized to receive either colchicine 0.6 mg twice per day (n = 274) or placebo (n = 275). Treatment lasted from 2 to 6 years. The primary outcome was all-cause mortality. Secondary outcomes were liver-related morbidity and mortality. Liver biopsy was requested prior to entry and after 24 months of treatment. Attendance at scheduled clinic visits and adherence with study medication were similar in colchicine and placebo groups. Alcohol intake was less than 1 drink per day in 69% of patients. In an intention-to-treat analysis, all-cause mortality was similar in colchicine (49%) and placebo (45%) patients (P = .371). Mortality attributed to liver disease was 32% in colchicine and 28% in placebo patients (P = .337). Fewer patients receiving colchicine developed hepatorenal syndrome. In 54 patients with repeat liver biopsies after 24 or more months of treatment, cirrhosis improved to septal fibrosis in 7 patients (3 colchicine, 4 placebo) and to portal fibrosis in 1 patient (colchicine). In patients with advanced alcoholic cirrhosis, colchicine does not reduce overall or liver-specific mortality. Liver histology improves to septal fibrosis in a minority of patients after 24 months of treatment, with similar rates of improvement in patients receiving placebo and colchicine. Colchicine is not recommended for patients with advanced alcoholic cirrhosis. JF - Gastroenterology AU - Morgan, Timothy R AU - Weiss, David G AU - Nemchausky, Bernard AU - Schiff, Eugene R AU - Anand, Bhupinder AU - Simon, Francis AU - Kidao, Jayashri AU - Cecil, Bennet AU - Mendenhall, Charles L AU - Nelson, Douglas AU - Lieber, Charles AU - Pedrosa, Marcos AU - Jeffers, Lennox AU - Bloor, John AU - Lumeng, Lawrence AU - Marsano, Luis AU - McClain, Craig AU - Mishra, Girish AU - Myers, Brent AU - Leo, Maria AU - Ponomarenko, Yelena AU - Taylor, Derek AU - Chedid, Antonio AU - French, Samuel AU - Kanel, Gary AU - Murray, Natalie AU - Pinto, Paul AU - Fong, Tse-Ling AU - Sather, Mike R AD - VA Long Beach Healthcare Systems, Long Beach, CA 90822, USA. timothy.morgan@med.va.gov Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 882 EP - 890 VL - 128 IS - 4 SN - 0016-5085, 0016-5085 KW - Colchicine KW - SML2Y3J35T KW - Abridged Index Medicus KW - Index Medicus KW - Treatment Failure KW - Liver -- pathology KW - Double-Blind Method KW - Liver -- drug effects KW - Humans KW - Middle Aged KW - Morbidity KW - Male KW - Female KW - Survival Analysis KW - Liver Cirrhosis, Alcoholic -- pathology KW - Liver Cirrhosis, Alcoholic -- mortality KW - Colchicine -- therapeutic use KW - Liver Cirrhosis, Alcoholic -- epidemiology KW - Liver Cirrhosis, Alcoholic -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67728831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Colchicine+treatment+of+alcoholic+cirrhosis%3A+a+randomized%2C+placebo-controlled+clinical+trial+of+patient+survival.&rft.au=Morgan%2C+Timothy+R%3BWeiss%2C+David+G%3BNemchausky%2C+Bernard%3BSchiff%2C+Eugene+R%3BAnand%2C+Bhupinder%3BSimon%2C+Francis%3BKidao%2C+Jayashri%3BCecil%2C+Bennet%3BMendenhall%2C+Charles+L%3BNelson%2C+Douglas%3BLieber%2C+Charles%3BPedrosa%2C+Marcos%3BJeffers%2C+Lennox%3BBloor%2C+John%3BLumeng%2C+Lawrence%3BMarsano%2C+Luis%3BMcClain%2C+Craig%3BMishra%2C+Girish%3BMyers%2C+Brent%3BLeo%2C+Maria%3BPonomarenko%2C+Yelena%3BTaylor%2C+Derek%3BChedid%2C+Antonio%3BFrench%2C+Samuel%3BKanel%2C+Gary%3BMurray%2C+Natalie%3BPinto%2C+Paul%3BFong%2C+Tse-Ling%3BSather%2C+Mike+R&rft.aulast=Morgan&rft.aufirst=Timothy&rft.date=2005-04-01&rft.volume=128&rft.issue=4&rft.spage=882&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-12 N1 - Date created - 2005-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Helicobacter pylori VacA, a paradigm for toxin multifunctionality. AN - 67704125; 15759043 AB - Bacterial protein toxins alter eukaryotic cellular processes and enable bacteria to successfully colonize their hosts. In recent years, there has been increased recognition that many bacterial toxins are multifunctional proteins that can have pleiotropic effects on mammalian cells and tissues. In this review, we examine a multifunctional toxin (VacA) that is produced by the bacterium Helicobacter pylori. The actions of H. pylori VacA represent a paradigm for how bacterial secreted toxins contribute to colonization and virulence in multiple ways. JF - Nature reviews. Microbiology AU - Cover, Timothy L AU - Blanke, Steven R AD - Departments of Medicine, and Microbiology and Immunology, Division of Infectious Diseases, Vanderbilt University School of Medicine and Veterans Administration Medical Center, Nashville, Tennessee 37232, USA. timothy.l.cover@vanderbilt.edu Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 320 EP - 332 VL - 3 IS - 4 SN - 1740-1526, 1740-1526 KW - Bacterial Proteins KW - 0 KW - Bacterial Toxins KW - VacA protein, Helicobacter pylori KW - Index Medicus KW - Virulence KW - Stomach Neoplasms -- microbiology KW - Antigen Presentation KW - Animals KW - Gastric Mucosa -- microbiology KW - Epithelial Cells -- physiology KW - Peptic Ulcer -- microbiology KW - T-Lymphocytes -- microbiology KW - Humans KW - Epithelial Cells -- microbiology KW - Phagocytosis KW - T-Lymphocytes -- immunology KW - Bacterial Toxins -- genetics KW - Bacterial Proteins -- genetics KW - Bacterial Proteins -- chemistry KW - Helicobacter Infections -- microbiology KW - Bacterial Toxins -- chemistry KW - Helicobacter pylori -- pathogenicity KW - Bacterial Toxins -- toxicity KW - Helicobacter pylori -- growth & development KW - Bacterial Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67704125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+reviews.+Microbiology&rft.atitle=Helicobacter+pylori+VacA%2C+a+paradigm+for+toxin+multifunctionality.&rft.au=Cover%2C+Timothy+L%3BBlanke%2C+Steven+R&rft.aulast=Cover&rft.aufirst=Timothy&rft.date=2005-04-01&rft.volume=3&rft.issue=4&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Microbiology&rft.issn=17401526&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-28 N1 - Date created - 2005-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Divalproex in the treatment of bipolar depression: a placebo-controlled study. AN - 67538568; 15780695 AB - The treatment of bipolar disorder in the depressed phase is complicated by a tendency for conventional antidepressant drugs to worsen the course of the illness by precipitating a manic episode or increasing cycle frequency. Thus, the potential antidepressant efficacy of mood stabilizers, such as divalproex, which is an effective treatment for the manic phase of bipolar disorder, is of considerable interest. The clinical efficacy of divalproex (valproate, Depakote) was tested in an 8-week, double-blind, placebo-controlled, randomized clinical trial in 25 outpatients with bipolar I depression. The primary outcome measure was the 17-item Hamilton Rating Scale for Depression, and secondary measures included the Hamilton Rating Scale for Anxiety, the Clinician Administered Rating Scale for Mania, and the Clinical Global Impression scale. Using repeated measures ANOVA with last observation carried forward, divalproex was more effective than placebo in improving symptoms of depression (p = 0.0002) and symptoms of anxiety (p = 0.0001) than placebo. The sample size was small, and most patients were male. These pilot results indicate that divalproex is effective in reducing the symptoms of depression and anxiety in bipolar I, depressed phase. These positive results support the need to perform a larger, multisite study of divalproex treatment for bipolar depression. JF - Journal of affective disorders AU - Davis, Lori L AU - Bartolucci, Al AU - Petty, Frederick AD - Veteran's Affairs Medical Center (151), 3701 Loop Road East, Tuscaloosa, AL 35404, USA. lori.davis@med.va.gov Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 259 EP - 266 VL - 85 IS - 3 SN - 0165-0327, 0165-0327 KW - Anticonvulsants KW - 0 KW - Antimanic Agents KW - Valproic Acid KW - 614OI1Z5WI KW - Index Medicus KW - Anxiety -- psychology KW - Double-Blind Method KW - Humans KW - Anxiety -- drug therapy KW - Personality Inventory KW - Ambulatory Care KW - Anxiety -- diagnosis KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Personality Assessment KW - Female KW - Male KW - Bipolar Disorder -- diagnosis KW - Bipolar Disorder -- drug therapy KW - Antimanic Agents -- adverse effects KW - Anticonvulsants -- adverse effects KW - Bipolar Disorder -- psychology KW - Antimanic Agents -- therapeutic use KW - Valproic Acid -- adverse effects KW - Valproic Acid -- therapeutic use KW - Anticonvulsants -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67538568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+affective+disorders&rft.atitle=Divalproex+in+the+treatment+of+bipolar+depression%3A+a+placebo-controlled+study.&rft.au=Davis%2C+Lori+L%3BBartolucci%2C+Al%3BPetty%2C+Frederick&rft.aulast=Davis&rft.aufirst=Lori&rft.date=2005-04-01&rft.volume=85&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Journal+of+affective+disorders&rft.issn=01650327&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-09 N1 - Date created - 2005-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence and distinct correlates of anxiety, substance, and combined comorbidity in a multi-site public sector sample with bipolar disorder. AN - 67538193; 15780700 AB - Recent data indicate high prevalence of both anxiety and substance comorbidity in bipolar disorder. However, few studies have utilized public sector samples, and only one has attempted to separate contributions of each type of comorbidity. 328 inpatient veterans with bipolar disorder across 11 sites were assessed using selected Structured Clinical Interview for DSM-IV modules and self-reports. Comorbidity was common (current: 57.3%; lifetime: 78.4%), with multiple current comorbidities in 29.8%. Substance comorbidity rate was comparable to rates typically reported in non-veteran inpatient samples (33.8% current, 72.3% lifetime). Selected anxiety comorbidity rates exceeded those in other inpatient samples and appeared more chronic than episodic/recurrent (38.3% current, 43.3% lifetime). 49% of PTSD was due to non-combat stressors. Major correlates of current substance comorbidity alone were younger age, worse marital status, and higher current employability. Correlates of current anxiety comorbidity alone were early age of onset, greater number of prior-year depressive episodes, higher rates of disability pension receipt, and lower self-reported mental and physical function. Combined comorbidity resembled anxiety comorbidity. This is a cross-sectional analysis of acutely hospitalized veterans. Distinct patterns of substance and anxiety comorbidity are striking, and may be subserved by distinct neurobiologic mechanisms. The prevalence, chronicity and functional impact of anxiety disorders indicate the need for improved recognition and treatment of this other dual diagnosis group is warranted. Clinical and research interventions should recognize these divergent comorbidity patterns and provide individualized treatment built "from the patient out." JF - Journal of affective disorders AU - Bauer, Mark S AU - Altshuler, Lori AU - Evans, Denise R AU - Beresford, Thomas AU - Williford, William O AU - Hauger, Richard AU - VA Cooperative Study #430 Team AD - VAMC and Brown University, 116R, 830 Chalkstone Avenue, Providence, RI 02908-4799, USA. mark.bauer@med.va.gov ; VA Cooperative Study #430 Team Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 301 EP - 315 VL - 85 IS - 3 SN - 0165-0327, 0165-0327 KW - Index Medicus KW - Public Sector KW - Humans KW - Aged KW - Combat Disorders -- epidemiology KW - Hospitals, Veterans -- statistics & numerical data KW - Comorbidity KW - Health Services Accessibility -- statistics & numerical data KW - California KW - Cross-Sectional Studies KW - Combat Disorders -- psychology KW - Pensions KW - Ambulatory Care -- statistics & numerical data KW - Adult KW - Combat Disorders -- diagnosis KW - Disability Evaluation KW - Middle Aged KW - Statistics as Topic KW - Personality Assessment KW - Hospitalization -- statistics & numerical data KW - Male KW - Female KW - Bipolar Disorder -- diagnosis KW - Alcoholism -- diagnosis KW - Anxiety Disorders -- psychology KW - Anxiety Disorders -- diagnosis KW - Veterans -- psychology KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Substance-Related Disorders -- diagnosis KW - Bipolar Disorder -- epidemiology KW - Veterans -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Bipolar Disorder -- psychology KW - Anxiety Disorders -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67538193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+affective+disorders&rft.atitle=Prevalence+and+distinct+correlates+of+anxiety%2C+substance%2C+and+combined+comorbidity+in+a+multi-site+public+sector+sample+with+bipolar+disorder.&rft.au=Bauer%2C+Mark+S%3BAltshuler%2C+Lori%3BEvans%2C+Denise+R%3BBeresford%2C+Thomas%3BWilliford%2C+William+O%3BHauger%2C+Richard%3B430+Team&rft.aulast=Bauer&rft.aufirst=Mark&rft.date=2005-04-01&rft.volume=85&rft.issue=3&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Journal+of+affective+disorders&rft.issn=01650327&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-09 N1 - Date created - 2005-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acrylonitrile potentiates hearing loss and cochlear damage induced by moderate noise exposure in rats. AN - 67535805; 15781293 AB - The diversity of chemical and drugs that can potentiate noise-induced hearing loss (NIHL) has impeded efforts to predict such interactions. We have hypothesized that chemical contaminants that disrupt intrinsic antioxidant defenses hold significant risk for potentiating NIHL. If this is true, then acrylonitrile (ACN) would be expected to potentiate NIHL. ACN, one of the 50 most commonly used chemicals in the United States, is metabolized via two pathways that are likely to disrupt intrinsic reactive oxygen species (ROS) buffering systems: (1) it conjugates glutathione, depleting this important antioxidant rapidly; (2) a second pathway involves the formation of cyanide, which can inhibit superoxide dismutase. We hypothesized that moderate noise exposure, that does not produce permanent hearing loss by itself, could initiate oxidative stress and that ACN could render the inner ear more sensitive to noise by disrupting intrinsic antioxidant defenses. Temporary and persistent effects of ACN alone (50 mg/kg, sc 5 days), noise alone (95 or 97 dB octave band noise, 4 h/day for 5 days), or ACN in combination with noise were determined using distortion product otoacoustic emissions (DPOAEs) and compound action potential (CAP) amplitudes. Histopathological damage to hair cells resulting from these treatments was also investigated using surface preparations of the organ of Corti. Individually, neither ACN nor noise exposures caused any permanent hearing or hair cell loss; only a reversible temporary threshold shift was measured in noise-exposed animals. However, when given in combination, ACN and noise induced permanent threshold shifts (13-16 dB between 7 and 40 kHz) and a decrease in DPOAE amplitudes (up to 25 dB at 19 kHz), as well as significant outer hair cell (OHC) loss (up to 20% in the first row between 13 and 47 kHz). This investigation demonstrates that ACN can potentiate NIHL at noise levels that are realistic in terms of human exposure, and that the OHCs are the main target of toxicity. While the exact mechanism is unknown, the results are consistent with the hypothesis of ROS involvement in NIHL at moderate levels. JF - Toxicology and applied pharmacology AU - Pouyatos, Benoît AU - Gearhart, Caroline A AU - Fechter, Laurence D AD - Jerry Pettis Memorial Veterans Medical Center, Research Service (151), 11201 Benton Street, Loma Linda, CA 92357, USA. benoit.pouyatos@med.va.gov Y1 - 2005/04/01/ PY - 2005 DA - 2005 Apr 01 SP - 46 EP - 56 VL - 204 IS - 1 SN - 0041-008X, 0041-008X KW - Acrylonitrile KW - MP1U0D42PE KW - Index Medicus KW - Rats KW - Animals KW - Rats, Long-Evans KW - Otoacoustic Emissions, Spontaneous KW - Auditory Threshold -- drug effects KW - Action Potentials -- drug effects KW - Male KW - Hearing Loss, Noise-Induced -- physiopathology KW - Hair Cells, Auditory, Outer -- physiopathology KW - Acrylonitrile -- toxicity KW - Hair Cells, Auditory, Outer -- drug effects KW - Hair Cells, Auditory, Outer -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67535805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Acrylonitrile+potentiates+hearing+loss+and+cochlear+damage+induced+by+moderate+noise+exposure+in+rats.&rft.au=Pouyatos%2C+Beno%C3%AEt%3BGearhart%2C+Caroline+A%3BFechter%2C+Laurence+D&rft.aulast=Pouyatos&rft.aufirst=Beno%C3%AEt&rft.date=2005-04-01&rft.volume=204&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-31 N1 - Date created - 2005-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Overexpression of vascular endothelial growth factor and its receptors in bronchial dypslasia demonstrated by quantitative RT-PCR analysis. AN - 67532499; 15777969 AB - Neoangiogenesis is required for the growth of invasive lung carcinoma, however, the role of angiogenesis in the progression of premalignant changes to carcinoma of the lung is less clear. We have evaluated vascular endothelial growth factor (VEGF) expression and microvessel densities (MVDs) in 62 bronchoscopic biopsies from normal, reactive (basal cell hyperplasia (BCH)) and dysplastic bronchial epithelium and in tissue from twenty-seven invasive lung carcinomas in an effort to demonstrate angiogenic activity in these preneoplastic lesions and determine whether it is associated with increased bronchial epithelial VEGF expression. MVDs and VEGF RNA expression measured by quantitative RT-PCR were found to be elevated in comparison to normal bronchial tissue in bronchial dysplasias and invasive lung carcinomas but not in basal cell hyperplasias. Immunohistochemical (IHC) analyses revealed that expression of VEGF arose predominantly from bronchial epithelium. ELISA analysis of lung tumor tissue showed that elevated VEGF protein expression correlated with VEGF RNA levels (r=0.59, p=0.004). Increased expression of VEGF RNA was also found in histologically normal bronchial mucosa from patients with either dysplasia at other sites or a history of heavy tobacco use suggesting a possible field effect in regard to the elaboration of VEGF. Furthermore, analysis of VEGF isoforms and VEGF receptors by semi-quantitative RT-PCR in dysplastic and invasive lesions revealed characteristic altered patterns of expression in dysplasia and early cancer as compared to normal tissue. These results indicate that angiogenesis develops early in lung carcinogenesis and is associated with overexpression of VEGF. JF - Lung cancer (Amsterdam, Netherlands) AU - Merrick, Daniel T AU - Haney, Jerry AU - Petrunich, Sheila AU - Sugita, Michio AU - Miller, York E AU - Keith, Robert L AU - Kennedy, Tim C AU - Franklin, Wilbur A AD - Department of Pathology, Denver Veteran's Affairs Medical Center, 1055 Clermont St., Denver, CO 80220, USA. Daniel.Merrick@med.va.gov Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 31 EP - 45 VL - 48 IS - 1 SN - 0169-5002, 0169-5002 KW - Vascular Endothelial Growth Factor A KW - 0 KW - RNA KW - 63231-63-0 KW - Receptors, Vascular Endothelial Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Neoplasm Invasiveness KW - Receptors, Vascular Endothelial Growth Factor -- metabolism KW - Humans KW - Receptors, Vascular Endothelial Growth Factor -- genetics KW - Receptors, Vascular Endothelial Growth Factor -- biosynthesis KW - Disease Progression KW - Smoking -- adverse effects KW - Enzyme-Linked Immunosorbent Assay KW - Biopsy KW - Up-Regulation KW - Reverse Transcriptase Polymerase Chain Reaction KW - Immunohistochemistry KW - RNA -- biosynthesis KW - Gene Expression Profiling KW - Vascular Endothelial Growth Factor A -- biosynthesis KW - Precancerous Conditions -- genetics KW - Precancerous Conditions -- blood supply KW - Lung Neoplasms -- blood supply KW - Lung Neoplasms -- genetics KW - Neovascularization, Pathologic KW - Vascular Endothelial Growth Factor A -- genetics KW - Precancerous Conditions -- pathology KW - Vascular Endothelial Growth Factor A -- metabolism KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67532499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lung+cancer+%28Amsterdam%2C+Netherlands%29&rft.atitle=Overexpression+of+vascular+endothelial+growth+factor+and+its+receptors+in+bronchial+dypslasia+demonstrated+by+quantitative+RT-PCR+analysis.&rft.au=Merrick%2C+Daniel+T%3BHaney%2C+Jerry%3BPetrunich%2C+Sheila%3BSugita%2C+Michio%3BMiller%2C+York+E%3BKeith%2C+Robert+L%3BKennedy%2C+Tim+C%3BFranklin%2C+Wilbur+A&rft.aulast=Merrick&rft.aufirst=Daniel&rft.date=2005-04-01&rft.volume=48&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Lung+cancer+%28Amsterdam%2C+Netherlands%29&rft.issn=01695002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-12 N1 - Date created - 2005-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Low-dose fluvoxamine as an adjunct to reduce olanzapine therapeutic dose requirements: a prospective dose-adjusted drug interaction strategy. AN - 67474409; 15738749 AB - Despite the advances in antipsychotic pharmacotherapy over the past decade, many atypical antipsychotic agents are not readily accessible by patients with major psychosis or in developing countries where the acquisition costs may be prohibitive. Olanzapine is an efficacious and widely prescribed atypical antipsychotic agent. In theory, olanzapine therapeutic dose requirement may be reduced during concurrent treatment with inhibitors of drug metabolism. In vitro studies suggest that smoking-inducible cytochrome P450 (CYP) 1A2 contributes to formation of the metabolite 4'-N-desmethylolanzapine. The present prospective study tested the hypothesis that olanzapine steady-state doses can be significantly decreased by coadministration of a low subclinical dose of fluvoxamine, a potent inhibitor of cytochrome P450 1A2. The study design followed a targeted "at-risk" population approach with a focus on smokers who were likely to exhibit increased cytochrome P450 1A2 expression. Patients with stable psychotic illness (N = 10 men, all smokers) and receiving chronic olanzapine treatment were evaluated for steady-state plasma concentrations of olanzapine and 4'-N-desmethylolanzapine. Subsequently, olanzapine dose was reduced from 17.5 +/- 4.2 mg/d (mean +/- SD) to 13.0 +/- 3.3 mg/d, and a nontherapeutic dose of fluvoxamine (25 mg/d, PO) was added to regimen. Patients were reevaluated at 2, 4, and 6 weeks during olanzapine-fluvoxamine cotreatment. There was no significant change in olanzapine plasma concentration, antipsychotic response, or metabolic indices (eg, serum glucose and lipids) after dose reduction in the presence of fluvoxamine (P > 0.05). 4'-N-desmethylolanzapine/olanzapine metabolic ratio decreased from 0.45 +/- 0.20 at baseline to 0.25 +/- 0.11 at week 6, suggesting inhibition of the cytochrome P450 1A2-mediated olanzapine 4'-N-demethylation by fluvoxamine (P < 0.05). In conclusion, this prospective pilot study suggests that a 26% reduction in olanzapine therapeutic dose requirement may be achieved by coadministration of a nontherapeutic oral dose of fluvoxamine. JF - Journal of clinical psychopharmacology AU - Albers, Lawrence J AU - Ozdemir, Vural AU - Marder, Stephen R AU - Raggi, Maria Augusta AU - Aravagiri, Manickam AU - Endrenyi, Laszlo AU - Reist, Christopher AD - VA Long Beach Healthcare System, Department of Psychiatry and Human Behavior, College of Medicine, University of California Irvine, CA 90822, USA. larry.albers@med.va.gov Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 170 EP - 174 VL - 25 IS - 2 SN - 0271-0749, 0271-0749 KW - Benzodiazepines KW - 12794-10-4 KW - olanzapine KW - N7U69T4SZR KW - Fluvoxamine KW - O4L1XPO44W KW - Index Medicus KW - Drug Therapy, Combination KW - Prospective Studies KW - Humans KW - Pilot Projects KW - Middle Aged KW - Drug Interactions -- physiology KW - Psychotic Disorders -- blood KW - Benzodiazepines -- blood KW - Fluvoxamine -- blood KW - Benzodiazepines -- administration & dosage KW - Psychotic Disorders -- drug therapy KW - Fluvoxamine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67474409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Low-dose+fluvoxamine+as+an+adjunct+to+reduce+olanzapine+therapeutic+dose+requirements%3A+a+prospective+dose-adjusted+drug+interaction+strategy.&rft.au=Albers%2C+Lawrence+J%3BOzdemir%2C+Vural%3BMarder%2C+Stephen+R%3BRaggi%2C+Maria+Augusta%3BAravagiri%2C+Manickam%3BEndrenyi%2C+Laszlo%3BReist%2C+Christopher&rft.aulast=Albers&rft.aufirst=Lawrence&rft.date=2005-04-01&rft.volume=25&rft.issue=2&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-15 N1 - Date created - 2005-03-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Psychopharmacol. 2005 Dec;25(6):626-7; author reply 627-8 [16282861] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Art of Prescribing. Mitigating Cognitive Side Effects Associated with Topiramate AN - 20236778; 6618706 JF - Perspectives in Psychiatric Care AU - Antai-Otong, Deborah Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - 92 EP - 93 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 41 IS - 2 SN - 0031-5990, 0031-5990 KW - Toxicology Abstracts KW - Cognitive ability KW - topiramate KW - Side effects KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20236778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+in+Psychiatric+Care&rft.atitle=The+Art+of+Prescribing.+Mitigating+Cognitive+Side+Effects+Associated+with+Topiramate&rft.au=Antai-Otong%2C+Deborah&rft.aulast=Antai-Otong&rft.aufirst=Deborah&rft.date=2005-04-01&rft.volume=41&rft.issue=2&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Perspectives+in+Psychiatric+Care&rft.issn=00315990&rft_id=info:doi/10.1111%2Fj.1744-6163.2005.00018.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - SuppNotes - References, 16. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cognitive ability; topiramate; Side effects DO - http://dx.doi.org/10.1111/j.1744-6163.2005.00018.x ER - TY - JOUR T1 - Cigarettes, alcohol, and depression: Characterizing head and neck cancer survivors in two systems of care AN - 17649701; 6469058 AB - Tobacco exposure is a key risk factor for head and neck cancer, and continued smoking after diagnosis negatively affects outcomes. The present study examined tobacco smoking, nicotine dependence, alcohol use, and depression in survivors of head and neck cancer. Subjects at least 6 months post-initial diagnosis of head and neck cancer (N = 694) drawn from three VA otolaryngology clinics (n = 309, VA patients) and a university-based otolaryngology clinic (n = 385, non-VA patients) were administered questionnaires and standardized rating instruments for nicotine and alcohol dependence and for depression. Additional clinical information was extracted from chart reviews. Despite high rates of prior smoking, less than one-quarter of all subjects continued to smoke. After controlling for significant confounding variables, we found that VA patients were more likely to be current smokers (OR = 1.9, 95% CI = 1.3-3.0), but current VA smokers did not differ significantly from non-VA smokers on the Fagerstroem Test for Nicotine Dependence criterion (p = .69). The VA patients were more likely to screen positive for problem drinking on the Alcohol Use Disorder Identification Test (OR = 2.1, 95% CI = 1.3-3.7). After adjusting for other variables, we found no statistical difference between the groups in depression scores on the Geriatric Depression Scale-Short Form. The study provides data on smoking, alcohol use, and depression in head and neck cancer survivors indicating that VA patients are at increased risk for continued smoking and problem drinking relative to non-VA patients. Head and neck cancer patients benefit from aggressive smoking cessation efforts by the VA, but many patients need specialized services that integrate smoking interventions with treatment of comorbid alcoholism. JF - Nicotine & Tobacco Research AU - Lambert, M T AU - Terrell, JE AU - Copeland, LA AU - Ronis, D L AU - Duffy, SA AD - Fort Worth VA Mental Health Clinic, 6000 Western Place, Suite 300, Fort Worth, TX 76107-4607, USA, michael.lambert2@med.va.gov Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - 233 EP - 241 VL - 7 IS - 2 SN - 1462-2203, 1462-2203 KW - Toxicology Abstracts KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17649701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+Tobacco+Research&rft.atitle=Cigarettes%2C+alcohol%2C+and+depression%3A+Characterizing+head+and+neck+cancer+survivors+in+two+systems+of+care&rft.au=Lambert%2C+M+T%3BTerrell%2C+JE%3BCopeland%2C+LA%3BRonis%2C+D+L%3BDuffy%2C+SA&rft.aulast=Lambert&rft.aufirst=M&rft.date=2005-04-01&rft.volume=7&rft.issue=2&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+Tobacco+Research&rft.issn=14622203&rft_id=info:doi/10.1080%2F14622200500055418 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-10-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1080/14622200500055418 ER - TY - JOUR T1 - Experimentally induced pain perception is acutely reduced by aerobic exercise in people with chronic low back pain AN - 17361834; 6433700 AB - This study examined whether subjects with chronic low back pain demonstrate exercise-induced analgesia to experimentally induced pressure pain. We employed a repeated measures design to study eight subjects with chronic low back pain (mean +/- standard deviation age = 40 +/- 10, duration of pain = 7 +/- 4 years). Pain ratings were measured immediately before and 2 minutes and 32 minutes after 25 minutes of cycle ergometry (5 minutes at 50% peak oxygen uptake, then 20 minutes at 70% peak oxygen uptake). We based the pain ratings on subject input on a visual analog scale at 10-second intervals during the 2-minute pressure pain stimulus to the non-dominant index finger. Compared with preexercise values, pain ratings were significantly (p < 0.05) decreased after exercise at both 2 and 32 minutes postexercise. We conclude that pressure pain perception can be reduced for more than 30 minutes following aerobic exercise from leg cycling among people with chronic low back pain. JF - Journal of Rehabilitation Research and Development AU - Hoffman, MD AU - Shepanski, MA AU - MacKenzie, S P AU - Clifford, P S AD - Department of Physical Medicine and Rehabilitation (117), Sacramento VA Medical Center, 10535 Hospital Way, Mather, CA 95655-1200, USA, martin.hoffman@med.va.gov Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - 183 EP - 190 VL - 42 IS - 2 SN - 0748-7711, 0748-7711 KW - Physical Education Index KW - Fingers KW - Measurement KW - Research (statistical design) KW - Perception KW - Ergometry KW - Stress KW - Pain KW - Legs KW - Exercise (programs) KW - Backache KW - PE 110:Physical Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17361834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Experimentally+induced+pain+perception+is+acutely+reduced+by+aerobic+exercise+in+people+with+chronic+low+back+pain&rft.au=Hoffman%2C+MD%3BShepanski%2C+MA%3BMacKenzie%2C+S+P%3BClifford%2C+P+S&rft.aulast=Hoffman&rft.aufirst=MD&rft.date=2005-04-01&rft.volume=42&rft.issue=2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2004.06.0065 LA - English DB - Physical Education Index N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Measurement; Fingers; Research (statistical design); Perception; Ergometry; Stress; Legs; Pain; Exercise (programs); Backache DO - http://dx.doi.org/10.1682/JRRD.2004.06.0065 ER - TY - JOUR T1 - Insulin Sensitivity Determines the Effectiveness of Dietary Macronutrient Composition on Weight Loss in Obese Women AN - 17339307; 6269913 AB - OBJECTIVE: To determine whether macronutrient composition of a hypocaloric diet can enhance its effectiveness and whether insulin sensitivity (Si) affects the response to hypocaloric diets. RESEARCH METHODS AND PROCEDURES: Obese nondiabetic insulin-sensitive (fasting insulin 15 mu U/mL; n = 9) women (23 to 53 years old) were randomized to either a high carbohydrate (CHO) (HC)/low fat (LF) (60% CHO, 20% fat) or low CHO (LC)/high fat (HF) (40% CHO, 40% fat) hypocaloric diet. Primary outcome measures after a 16-week dietary intervention were: changes in body weight (BW), Si, resting metabolic rate, and fasting lipids. RESULTS: Insulin-sensitive women on the HC/LF diet lost 13.5 plus or minus 1.2% (p < 0.001) of their initial BW, whereas those on the LC/HF diet lost 6.8 plus or minus 1.2% (p < 0.001; p < 0.002 between the groups). In contrast, among the insulin-resistant women, those on the LC/HF diet lost 13.4 plus or minus 1.3% (p < 0.001) of their initial BW as compared with 8.5 plus or minus 1.4% (p < 0.001) lost by those on the HC/LF diet (p < 0.04 between two groups). These differences could not be explained by changes in resting metabolic rate, activity, or intake. Overall, changes in Si were associated with the degree of weight loss (r = -0.57, p < 0.05). DISCUSSION: The state of Si determines the effectiveness of macronutrient composition of hypocaloric diets in obese women. For maximal benefit, the macronutrient composition of a hypocaloric diet may need to be adjusted to correspond to the state of Si. JF - Obesity Research AU - Cornier, Marc-Andre AU - Donahoo, WTroy AU - Pereira, Rocio AU - Gurevich, Inga AU - Westergren, Rickard AU - Enerback, Sven AU - Eckel, Peter J AU - Goalstone, Marc L AU - Hill, James O AU - Eckel, Robert H AU - Draznin, Boris AD - Departments of Medicine and. Pediatrics, Adult General Clinical Research Center, and the. Center for Human Nutrition, University of Colorado Health Sciences Center, Research Service of the Denver Veterans Administration Medical Center, Denver, Colorado. Medical Genetics, Department of Medical Biochemistry, Gothenburg University, Goteborg, Sweden Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - 703 EP - 709 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 13 IS - 4 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Obesity KW - Weight control KW - Lipids KW - Women KW - Diet (weight control) KW - Basal metabolic rate KW - Carbohydrates KW - Hormones KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17339307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Insulin+Sensitivity+Determines+the+Effectiveness+of+Dietary+Macronutrient+Composition+on+Weight+Loss+in+Obese+Women&rft.au=Cornier%2C+Marc-Andre%3BDonahoo%2C+WTroy%3BPereira%2C+Rocio%3BGurevich%2C+Inga%3BWestergren%2C+Rickard%3BEnerback%2C+Sven%3BEckel%2C+Peter+J%3BGoalstone%2C+Marc+L%3BHill%2C+James+O%3BEckel%2C+Robert+H%3BDraznin%2C+Boris&rft.aulast=Cornier&rft.aufirst=Marc-Andre&rft.date=2005-04-01&rft.volume=13&rft.issue=4&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Obesity; Weight control; Lipids; Women; Diet (weight control); Basal metabolic rate; Carbohydrates; Hormones ER - TY - JOUR T1 - Understanding regulation of nerve cell death by mGluRs as a method for development of successful neuroprotective strategies. AN - 67508708; 15760640 AB - A common cause of nerve cell death often leading to vascular dementia is ischemic stroke. Attempts to develop clinically effective stroke treatment and prevention strategies based on pharmacological manipulations of a single mechanism have not led to clinical success. Analysis of clinical neuroprotection trials suggests that combination treatments may be more effective. To identify optimal components for such treatment, N-methyl-d-aspartate receptor (NMDAR) activation-induced cell death in organotypic hippocampal preparations was studied as a model of neurodegeneration that occurs in association with stroke or vascular dementia. Pharmacological manipulation of metabotropic glutamate receptors mGluR1 and 5 resulted in significant reduction of nerve cell susceptibility to NMDA-induced injury, suggesting that these receptors may function as physiological regulators of neuronal vulnerability. cDNA microarray analysis of over 1000 brain-related genes performed after the neuroprotective activation of group I metabotropic glutamate receptors (mGluRs) revealed a complex pattern of activation and inactivation of seemingly unrelated genes responsible for regulation of neuronal excitability, inflammation, cell death pathways, cell adhesion and transcriptional activation. Combined pharmacological targeting of these processes may provide basis for clinical trials of effective neuroprotective compounds. JF - Journal of the neurological sciences AU - Baskys, Andrius AU - Blaabjerg, Morten AD - 06/116 VA Health Care System MIRECC, 5901 E. 7th street, Long Beach, CA 90822, USA. andrius.baskys@med.va.gov Y1 - 2005/03/15/ PY - 2005 DA - 2005 Mar 15 SP - 201 EP - 209 VL - 229-230 SN - 0022-510X, 0022-510X KW - Excitatory Amino Acids KW - 0 KW - Neuroprotective Agents KW - Receptors, Metabotropic Glutamate KW - Glutamic Acid KW - 3KX376GY7L KW - Methoxyhydroxyphenylglycol KW - 534-82-7 KW - dihydroxyphenylethylene glycol KW - CF5G2G268A KW - Index Medicus KW - Animals KW - Cell Adhesion -- physiology KW - Humans KW - Excitatory Amino Acids -- toxicity KW - Glutamic Acid -- pharmacology KW - Inflammation -- pathology KW - Methoxyhydroxyphenylglycol -- metabolism KW - Cell Death -- physiology KW - Neurons -- physiology KW - Methoxyhydroxyphenylglycol -- analogs & derivatives KW - Receptors, Metabotropic Glutamate -- physiology KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67508708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+neurological+sciences&rft.atitle=Understanding+regulation+of+nerve+cell+death+by+mGluRs+as+a+method+for+development+of+successful+neuroprotective+strategies.&rft.au=Baskys%2C+Andrius%3BBlaabjerg%2C+Morten&rft.aulast=Baskys&rft.aufirst=Andrius&rft.date=2005-03-15&rft.volume=229-230&rft.issue=&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+neurological+sciences&rft.issn=0022510X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-03 N1 - Date created - 2005-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Symptom and function change with mindfulness meditation in PTSD veterans AN - 39971792; 3921747 AU - Farr, D AU - Billig, J AU - Landes, A AU - Thuras, P Y1 - 2005/03/15/ PY - 2005 DA - 2005 Mar 15 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39971792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Symptom+and+function+change+with+mindfulness+meditation+in+PTSD+veterans&rft.au=Farr%2C+D%3BBillig%2C+J%3BLandes%2C+A%3BThuras%2C+P&rft.aulast=Farr&rft.aufirst=D&rft.date=2005-03-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ISTSS, Intl. Soc. f. Traumatic Stress Studies, 60 Revere Drive, Suite 500, Northbrook, IL 60062, USA; phone: (847) 480-9028; fax: (847) 480-9282; email: istss@istss.org; URL: www.istss.org N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy AN - 17865635; 6216410 AB - There is little systematic information regarding the immune reconstitution inflammatory syndrome (IRIS). Objective: To determine the incidence, risk factors, and long-term outcome of IRIS in HIV-infected patients receiving highly active antiretroviral therapy (HAART) who were coinfected with one of three common opportunistic pathogens. Design: A retrospective cohort identified through a city-wide prospective surveillance program. Methods: A retrospective chart review was performed for 180 HIV-infected patients who received HAART and were coinfected with Mycobacterium tuberculosis, Mycobacterium avium complex, or Cryptococcus neoformans between 1997 and 2000. Medical records were reviewed for baseline demographics, receipt and type of HAART, response to antiretroviral therapy, development of IRIS, and long-term outcome. Results: In this cohort, 31.7% of patients who received HAART developed IRIS. Patients with IRIS were more likely to have initiated HAART nearer to the time of diagnosis of their opportunistic infection (P < 0.001), to have been antiretroviral naive at time of diagnosis of their opportunistic infection (P < 0.001), and to have a more rapid initial fall in HIV-1 RNA level in response to HAART (P < 0.001). Conclusions: IRIS is common among HIV-infected persons coinfected with M. tuberculosis, M. avium complex, or C. neoformans. Antiretroviral drug-naive patients who start HAART in close proximity to the diagnosis of an opportunistic infection and have a rapid decline in HIV-1 RNA level should be monitored for development of this disorder. JF - AIDS AU - Shelburne, SA AU - Visnegarwala, F AU - Darcourt, J AU - Graviss, E A AU - Giordano, T P AU - White, AC Jr AU - Hamill, R J AD - Section of Infectious Diseases (111G), Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, Texas 77030-4211, USA, richard.hamill@med.va.gov Y1 - 2005/03/04/ PY - 2005 DA - 2005 Mar 04 SP - 399 EP - 406 VL - 19 IS - 4 SN - 0269-9370, 0269-9370 KW - HIV-1 KW - Risk Abstracts; Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Acquired immune deficiency syndrome KW - Mycobacterium avium KW - antiretroviral agents KW - medical records KW - Opportunist infection KW - Information systems KW - Mycobacterium tuberculosis KW - Demography KW - Cryptococcus neoformans KW - Risk factors KW - Human immunodeficiency virus 1 KW - infection KW - Tuberculosis KW - antiretroviral therapy KW - Pathogens KW - Inflammation KW - tuberculosis KW - highly active antiretroviral therapy KW - Reviews KW - Side effects KW - K 03087:Fungi: human KW - R2 23060:Medical and environmental health KW - J 02845:Ear, nose and respiratory tract KW - V 22004:AIDS: Clinical aspects KW - H 4000:Food and Drugs KW - F 06104:Virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17865635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Incidence+and+risk+factors+for+immune+reconstitution+inflammatory+syndrome+during+highly+active+antiretroviral+therapy&rft.au=Shelburne%2C+SA%3BVisnegarwala%2C+F%3BDarcourt%2C+J%3BGraviss%2C+E+A%3BGiordano%2C+T+P%3BWhite%2C+AC+Jr%3BHamill%2C+R+J&rft.aulast=Shelburne&rft.aufirst=SA&rft.date=2005-03-04&rft.volume=19&rft.issue=4&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus 1; Mycobacterium avium; Mycobacterium tuberculosis; Cryptococcus neoformans; antiretroviral agents; infection; Reviews; tuberculosis; Side effects; Acquired immune deficiency syndrome; highly active antiretroviral therapy; Opportunist infection; Inflammation; Risk factors; Tuberculosis; Information systems; medical records; Demography; antiretroviral therapy; Pathogens ER - TY - JOUR T1 - Semantic Priming in Patients with Right Frontal Lobe Lesions AN - 85631366; 200600772 AB - Patients with unilateral, right frontal lobe damage (N = 13) & matched controls (N = 20) performed a task of lexical ambiguity resolution in order to explore the contribution of right frontal regions to lexical-semantic priming. Word triplets consisting of balanced homographs were presented to participants in four conditions: concordant, discordant, neutral, & unrelated. Controls demonstrated facilitation for concordant meanings of homographs, as evidenced by their faster reaction times in the concordant relative to the unrelated (baseline) condition, as well as a lack of facilitation for the discordant meaning relative to the neutral & concordant conditions. Results in patients with right frontal lobe damage differed depending on the site of the lesion. Patients with lesions restricted to the right medial frontal lobe only showed facilitation in the neutral condition, while those with lesions encroaching upon the right dorsolateral region demonstrated facilitation of both discordant & concordant meanings relative to the baseline condition. These results support a role for the right frontal lobe in semantic priming & suggest possible specialization within the right prefrontal cortex for the processing of lexical-semantic information. 4 Tables, 1 Figure, 52 References. Adapted from the source document JF - Journal of the International Neuropsychological Society AU - McDonald, Carrie R AU - Bauer, Russell M AU - Filoteo, J Vincent AU - Grande, Laura AU - Roper, Steven N AU - Buchanan, Robert J AU - Gilmore, Robin AD - Psychology Service (116B) Delis Lab, Veterans Administration San Diego Healthcare System, La Jolla, CA camcdonald@ucsd.edu Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 132 EP - 143 VL - 11 IS - 2 SN - 1355-6177, 1355-6177 KW - Cerebral Dominance (11500) KW - Priming (67670) KW - Brain Damage (09400) KW - Brain (09350) KW - Ambiguity (01950) KW - Word Meaning (97700) KW - Homographs (32350) KW - Response Time (Psychology) (73130) KW - Semantic Processing (76760) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85631366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society&rft.atitle=Semantic+Priming+in+Patients+with+Right+Frontal+Lobe+Lesions&rft.au=McDonald%2C+Carrie+R%3BBauer%2C+Russell+M%3BFiloteo%2C+J+Vincent%3BGrande%2C+Laura%3BRoper%2C+Steven+N%3BBuchanan%2C+Robert+J%3BGilmore%2C+Robin&rft.aulast=McDonald&rft.aufirst=Carrie&rft.date=2005-03-01&rft.volume=11&rft.issue=2&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society&rft.issn=13556177&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2006-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JINSF9 N1 - SubjectsTermNotLitGenreText - Semantic Processing (76760); Brain Damage (09400); Priming (67670); Ambiguity (01950); Brain (09350); Word Meaning (97700); Homographs (32350); Response Time (Psychology) (73130); Cerebral Dominance (11500) ER - TY - JOUR T1 - Semantic Activation within and across the Cerebral Hemispheres: What's Left Isn't Right AN - 85624545; 200600788 AB - This study examined differences in the spread of semantic activation within & between the cerebral hemispheres. A lateralized lexical decision task using indirect priming was presented to 58 undergraduates with primes & targets separated by 215 or 750 milliseconds (ms). Prime & target words were presented to the same or opposite visual fields & were either directly related (book-read), indirectly related (lion-[tiger]-stripes), or unrelated (cup-street). At 215 ms, participants exhibited significant priming effects to directly related words in all conditions except when primes & targets were both presented to the right hemisphere (RH). In contrast, priming to indirectly related words was effective only when primes & targets were presented to opposite hemispheres. At 750 ms, significant priming occurred for directly related words in all conditions & for indirectly related words when primes were presented to the RH. Results suggest that priming for directly & indirectly related concepts occurs unilaterally in each hemisphere before 215 ms. Both prime types activate semantic networks in the RH within 750 ms, whereas the LH processes information in a more focused manner. This suggests that activation spreads contralaterally from each hemisphere first to directly & then to indirectly related concepts, indicating the importance of incorporating contralateral priming contrasts in lexical decision tasks. 2 Tables, 1 Appendix, 42 References. Adapted from the source document JF - Laterality: Asymmetries of Body, Brain and Cognition AU - Yochim, Brian P AU - Kender, Robert AU - Abeare, Christopher AU - Gustafson, Angela AU - Whitman, R Douglas AD - VA Northern California Health Care System, Martinez, CA Brian.Yochim@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 131 EP - 148 VL - 10 IS - 2 SN - 1357-650X, 1357-650X KW - Associative Processes (05300) KW - Priming (67670) KW - Cerebral Dominance (11500) KW - Lexical Decision Task (46645) KW - College Students (13250) KW - Semantic Fields (76710) KW - Semantic Processing (76760) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85624545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laterality%3A+Asymmetries+of+Body%2C+Brain+and+Cognition&rft.atitle=Semantic+Activation+within+and+across+the+Cerebral+Hemispheres%3A+What%27s+Left+Isn%27t+Right&rft.au=Yochim%2C+Brian+P%3BKender%2C+Robert%3BAbeare%2C+Christopher%3BGustafson%2C+Angela%3BWhitman%2C+R+Douglas&rft.aulast=Yochim&rft.aufirst=Brian&rft.date=2005-03-01&rft.volume=10&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Laterality%3A+Asymmetries+of+Body%2C+Brain+and+Cognition&rft.issn=1357650X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2006-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - LATEFV N1 - SubjectsTermNotLitGenreText - Semantic Processing (76760); Cerebral Dominance (11500); Lexical Decision Task (46645); Priming (67670); College Students (13250); Associative Processes (05300); Semantic Fields (76710) ER - TY - JOUR T1 - Harmaline-induced tremor as a potential preclinical screening method for essential tremor medications. AN - 85382636; pmid-15580562 AB - No preclinical method to evaluate potential new medications for essential tremor (ET) is available currently. Although harmaline tremor is a well known animal model of ET, it has not found utility as a preclinical drug screen and has not been validated with anti-ET medications. We measured harmaline tremor in rats (10 mg/kg s.c.) and mice (20 mg/kg s.c.) with a load sensor under the cage floor and performed spectral analysis on 20-minute epochs. The motion power over the tremor frequency bandwidth (8-12 Hz in rats; 10-16 Hz in mice) was divided by the motion power over the full motion frequency range (0-15 Hz in rats; 0-34 Hz in mice). The use of these measures greatly reduced data variability, permitting experiments with small sample sizes. Three drugs that suppress ET (propranolol, ethanol, and octanol) all significantly suppressed harmaline-induced tremor. We propose that, with this methodology, harmaline-induced tremor may be useful as a preclinical method to identify potential medications for ET.2005 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Martin, Fredricka C AU - Thu Le, Anh AU - Handforth, Adrian AD - Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA. fredricka.martin@med.va.gov Y1 - 2005/03// PY - 2005 DA - Mar 2005 SP - 298 EP - 305 VL - 20 IS - 3 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Central Nervous System Depressants: pharmacology KW - *Central Nervous System Depressants: therapeutic use KW - *Central Nervous System Stimulants: adverse effects KW - Essential Tremor: chemically induced KW - Essential Tremor: diagnosis KW - Essential Tremor: drug therapy KW - Ethanol: pharmacology KW - *Ethanol: therapeutic use KW - Female KW - *Harmaline: adverse effects KW - Locomotion: drug effects KW - Mice KW - Mice, Inbred ICR KW - Propranolol: pharmacology KW - *Propranolol: therapeutic use KW - Rats KW - Rats, Sprague-Dawley KW - Severity of Illness Index KW - Vasodilator Agents: pharmacology KW - *Vasodilator Agents: therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85382636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Harmaline-induced+tremor+as+a+potential+preclinical+screening+method+for+essential+tremor+medications.&rft.au=Martin%2C+Fredricka+C%3BThu+Le%2C+Anh%3BHandforth%2C+Adrian&rft.aulast=Martin&rft.aufirst=Fredricka&rft.date=2005-03-01&rft.volume=20&rft.issue=3&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Glucocorticoid-induced osteoporosis: treatment options and guidelines. AN - 68062243; 16036098 AB - Glucocorticoid-induced osteoporosis and fractures are the most frequent adverse effects of this class of medication. Recent advances in the pathophysiology, epidemiology, detection, and prevention of this complication of therapy provide hope for its amelioration in patients who require treatment with glucocorticoids. A number of effective pharmacologic agents are available and/or under study, and scientific organizations now provide guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis. Unfortunately, consistent application of these guidelines remains suboptimal in many practice settings. JF - Current osteoporosis reports AU - Maricic, Michael AD - Southern Arizona VA Health Care System, 3601 S. 6th Avenue, Tucson, AZ 85723, USA. michael.maricic@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 25 EP - 29 VL - 3 IS - 1 SN - 1544-1873, 1544-1873 KW - Diphosphonates KW - 0 KW - Glucocorticoids KW - Parathyroid Hormone KW - Etidronic Acid KW - M2F465ROXU KW - Risedronate Sodium KW - OFG5EXG60L KW - Alendronate KW - X1J18R4W8P KW - Index Medicus KW - Diphosphonates -- therapeutic use KW - Bone Resorption KW - Guideline Adherence KW - Humans KW - Alendronate -- therapeutic use KW - Exercise KW - Etidronic Acid -- therapeutic use KW - Bone Density -- drug effects KW - Practice Guidelines as Topic KW - Parathyroid Hormone -- therapeutic use KW - Fractures, Bone -- chemically induced KW - Osteogenesis -- drug effects KW - Etidronic Acid -- analogs & derivatives KW - Female KW - Male KW - Osteoporosis -- prevention & control KW - Glucocorticoids -- administration & dosage KW - Glucocorticoids -- adverse effects KW - Glucocorticoids -- therapeutic use KW - Osteoporosis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68062243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+osteoporosis+reports&rft.atitle=Glucocorticoid-induced+osteoporosis%3A+treatment+options+and+guidelines.&rft.au=Maricic%2C+Michael&rft.aulast=Maricic&rft.aufirst=Michael&rft.date=2005-03-01&rft.volume=3&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Current+osteoporosis+reports&rft.issn=15441873&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-07 N1 - Date created - 2005-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association between fecal hydrogen sulfide production and pouchitis. AN - 67796585; 15747080 AB - The beneficial effect of antibiotics in pouchitis suggests that an unidentified fecal bacterial product causes this condition. A candidate compound is hydrogen sulfide, a highly toxic gas produced by certain fecal bacteria, which causes tissue injury in experimental models. We investigated hydrogen sulfide release and sulfate-reducing bacterial counts in pouch contents to determine whether hydrogen sulfide production correlates with pouchitis. During incubation at 37 degrees C, the production of hydrogen sulfide, methylmercaptan, carbon dioxide, and hydrogen were studied using fresh fecal specimens obtained from 50 patients with ileoanal pouches constructed after total proctocolectomy for ulcerative colitis (n = 45) or for familial adenomatous polyposis (n = 5). Patients with ulcerative colitis were divided into five groups: a) no history of pouchitis (pouch for at least 2 years; n = 8); b) past episode(s) of pouchitis but no active disease for the previous year (n = 9); c) pouchitis in the past year but presently inactive (n = 9); d) ongoing antibiotic treatment (metronidazole or ciprofloxacin) for pouchitis (n = 11); e) currently suffering from pouchitis (n = 8). Release of hydrogen sulfide when pouchitis was active (6.06 +/- 1.03 micromol g(-1) 4 h(-1)) or had occurred in the past year (4.71 +/- 0.41 pmol g(-1) 4 h(-1)) was significantly higher (P < 0.05) than when pouchitis had never occurred (1.71 +/- 0.43 micromol g(-1) 4 h(-1)) or had been inactive in the past year (2.62 +/- 0.49 micromol g(-1) 4 h(-1)). Antibiotic therapy was associated with very low hydrogen sulfide release (0.68 +/- 0.29 micromol g(-1) 4 h(-1)). Pouch contents from familial adenomatous polyposis patients produced significantly less hydrogen sulfide (0.75 +/- 0.09 micromol g(-1) 4 h(-1)) than did any group of nonantibiotic-treated ulcerative colitis patients. Sulfate-reducing bacterial counts in active pouchitis (9.5 +/- 0.5 log10/g) were significantly higher than in those who never experienced pouchitis (7.38 +/- 0.32 log10/g), and these counts fell dramatically with antibiotic treatment. No statistically significant differences in carbon dioxide and hydrogen were observed among the groups not receiving antibiotics. Pouch contents of patients with ongoing pouchitis or an episode within the previous year released significantly more hydrogen sulfide than did the contents of patients who never had an attack of pouchitis and those with longstanding inactive disease. The response to therapy with metronidazole or ciprofloxacin was associated with marked reductions in hydrogen sulfide release and sulfate-reducing bacteria. These results provide a rationale for additional studies to determine whether the high sulfide production is a cause or effect of pouchitis. The lower hydrogen sulfide production by pouch contents of familial adenomatous polyposis vs. patients with ulcerative colitis suggests a fundamental difference in gut sulfide metabolism that could have implications for the etiology of ulcerative colitis as well as the pouchitis of patients with ulcerative colitis. JF - Diseases of the colon and rectum AU - Ohge, Hiroki AU - Furne, Julie K AU - Springfield, John AU - Rothenberger, David A AU - Madoff, Robert D AU - Levitt, Michael D AD - Minneapolis Veterans Administration Medical Center, Minneapolis, Minnesota, USA. ohge@hiroshima-u.ac.jp Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 469 EP - 475 VL - 48 IS - 3 SN - 0012-3706, 0012-3706 KW - Anti-Infective Agents KW - 0 KW - Metronidazole KW - 140QMO216E KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Hydrogen Sulfide KW - YY9FVM7NSN KW - Index Medicus KW - Anti-Infective Agents -- therapeutic use KW - Sulfur-Reducing Bacteria -- physiology KW - Metronidazole -- therapeutic use KW - Humans KW - Ciprofloxacin -- therapeutic use KW - Male KW - Female KW - Colitis, Ulcerative -- complications KW - Pouchitis -- microbiology KW - Pouchitis -- drug therapy KW - Pouchitis -- physiopathology KW - Hydrogen Sulfide -- adverse effects KW - Feces -- chemistry KW - Hydrogen Sulfide -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67796585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diseases+of+the+colon+and+rectum&rft.atitle=Association+between+fecal+hydrogen+sulfide+production+and+pouchitis.&rft.au=Ohge%2C+Hiroki%3BFurne%2C+Julie+K%3BSpringfield%2C+John%3BRothenberger%2C+David+A%3BMadoff%2C+Robert+D%3BLevitt%2C+Michael+D&rft.aulast=Ohge&rft.aufirst=Hiroki&rft.date=2005-03-01&rft.volume=48&rft.issue=3&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Diseases+of+the+colon+and+rectum&rft.issn=00123706&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-24 N1 - Date created - 2005-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of a stem cell candidate in the normal human prostate gland. AN - 67725893; 15819412 AB - Stem cells of the human prostate gland have not yet been identified utilizing a structural biomarker. We have discovered a new prostatic epithelial cell phenotype-expressing cytokeratin 6a (Ck6a+ cells). The Ck6a+ cells are present within a specialized niche in the basal cell compartment in fetal, juvenile and adult prostate tissue, and within the stem cell-enriched urogenital sinus. In adult normal prostate tissue, the average abundance of Ck6a+ cells was 4.9%. With proliferative stimuli in the prostate organ culture model, in which the epithelial-stromal interaction was maintained, a remarkable increase of Ck6a expression was noticed to up to 64.9%. The difference in cytokeratin 6a expression between the normal adult prostate and the prostate organ culture model was statistically significant (p<0.0001). Within the prostate organ culture model the increase of cytokeratin 6a-expressing cells significantly correlated with increased proliferation index (r = 0.7616, p = 0.0467). The Ck6a+ cells were capable of differentiation as indicated by their expression of luminal cell markers such as ZO-1 and prostate specific antigen (PSA). Our data indicate that Ck6a+ cells represent a prostatic epithelial stem cell candidate possessing high potential for proliferation and differentiation. Since the development of benign prostatic hyperplasia and prostate carcinogenesis are disorders of proliferation and differentiation, the Ck6a+ cells may represent a major element in the development of these diseases. JF - European journal of cell biology AU - Schmelz, Monika AU - Moll, Roland AU - Hesse, Ulrike AU - Prasad, Anil R AU - Gandolfi, Jay A AU - Hasan, Shirin R AU - Bartholdi, Marty AU - Cress, Anne E AD - Department of Pathology, Southern Arizona Veterans Affairs Health Care System, 3601 S. 6th Ave., Tucson, AZ 85723, USA. monika.schmelz@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 341 EP - 354 VL - 84 IS - 2-3 SN - 0171-9335, 0171-9335 KW - Antibodies, Monoclonal KW - 0 KW - Biomarkers KW - Keratins KW - 68238-35-7 KW - Index Medicus KW - Keratins -- metabolism KW - Keratins -- genetics KW - Cell Differentiation -- physiology KW - Humans KW - Epithelium -- metabolism KW - Cell Proliferation KW - Fetus -- metabolism KW - Male KW - Prostate -- metabolism KW - Stem Cells KW - Prostate -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67725893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cell+biology&rft.atitle=Identification+of+a+stem+cell+candidate+in+the+normal+human+prostate+gland.&rft.au=Schmelz%2C+Monika%3BMoll%2C+Roland%3BHesse%2C+Ulrike%3BPrasad%2C+Anil+R%3BGandolfi%2C+Jay+A%3BHasan%2C+Shirin+R%3BBartholdi%2C+Marty%3BCress%2C+Anne+E&rft.aulast=Schmelz&rft.aufirst=Monika&rft.date=2005-03-01&rft.volume=84&rft.issue=2-3&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cell+biology&rft.issn=01719335&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-05 N1 - Date created - 2005-04-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Histochem Cytochem. 2001 Feb;49(2):271-8 [11156695] J Invest Dermatol. 2000 Nov;115(5):795-804 [11069616] Prostate. 2001 Oct 1;49(2):132-9 [11582592] Nature. 2001 Nov 1;414(6859):98-104 [11689954] J Cell Sci. 2001 Nov;114(Pt 21):3865-72 [11719553] Neoplasia. 2002 May-Jun;4(3):243-54 [11988844] Cell Biol Toxicol. 2002;18(3):205-19 [12083426] J Urol. 2002 Nov;168(5):2206-10 [12394760] J Invest Dermatol. 2003 Apr;120(4):512-22 [12648212] Tissue Cell. 2003 Apr;35(2):83-93 [12747930] Oncogene. 2003 Jun 19;22(25):3875-87 [12813461] Med Electron Microsc. 2003 Sep;36(3):147-56 [14505058] Urology. 2003 Nov;62(5 Suppl 1):11-20 [14607213] Nat Rev Cancer. 2003 Nov;3(11):832-44 [14668814] J Cell Sci. 2004 Apr 15;117(Pt 10):1989-99 [15090596] J Cell Sci. 2004 Jul 15;117(Pt 16):3539-45 [15226377] Invest Urol. 1978 Jan;15(4):340-5 [75197] J Biol Chem. 1978 Mar 25;253(6):2053-60 [416022] Anat Rec. 1980 Mar;196(3):263-73 [7406220] Cell. 1982 Nov;31(1):11-24 [6186379] Am J Clin Pathol. 1985 Apr;83(4):431-8 [2580429] Prostate. 1985;7(1):41-51 [4080651] Methods Enzymol. 1986;134:355-71 [2434826] Endocr Rev. 1987 Aug;8(3):338-62 [3308446] Prog Clin Biol Res. 1987;239:513-76 [3309963] Prostate. 1987;11(3):229-42 [3684783] Am J Surg Pathol. 1988 Aug;12(8):619-33 [2456702] Am J Clin Pathol. 1988 Nov;90(5):597-601 [2459960] J Invest Dermatol. 1989 May;92(5):707-16 [2469734] J Urol. 1990 Jan;143(1):167-71 [1688457] Prostate Suppl. 1989;2:33-50 [2482772] Mol Endocrinol. 1990 Dec;4(12):2003-13 [1707130] Cancer Res. 1992 Nov 15;52(22):6182-7 [1384957] Cancer Res. 1993 Oct 1;53(19):4720-6 [7691403] Hum Pathol. 1994 Jan;25(1):42-6 [7508883] Prostate. 1996 Feb;28(2):98-106 [8604398] Ann N Y Acad Sci. 1996 Apr 30;784:50-62 [8651606] Acta Anat (Basel). 1996;155(2):81-93 [8828706] Science. 1996 Dec 6;274(5293):1672-7 [8939849] Cancer. 1997 Apr 15;79(8):1595-9 [9118044] Eur Urol. 1997;32(3):332-8 [9358223] Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1735-40 [9465086] Genomics. 1998 Oct 15;53(2):170-83 [9790766] J Urol. 1998 Dec;160(6 Pt 2):2381-92 [9817389] Gastroenterology. 1999 Jan;116(1):7-14 [9869596] Subcell Biochem. 1998;31:173-204 [9932493] Lab Invest. 2000 Aug;80(8):1251-8 [10950116] J Pathol. 1999 Oct;189(2):213-8 [10547577] Cancer Metastasis Rev. 1998-1999;17(4):391-9 [10453283] Cell. 2001 Jan 26;104(2):233-45 [11207364] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationship of aging and tobacco use with the development of aberrant crypt foci in a predominantly African-American population. AN - 67513775; 15765447 AB - In clinical studies, diminished folate availability appears to increase the risk for colorectal neoplasms. Additionally, alcohol and tobacco use are associated with an increased risk for colon cancer, but the early pathologic events by which these agents promote neoplastic transformation are not well understood. Aberrant crypt foci (ACF) are potential precursors of adenoma and cancer, and can be visualized by magnification endoscopy. We hypothesized that folate depletion is linked to ACF formation and therefore studied the association between tissue folate, dietary habits, and ACF number in patients undergoing screening colonoscopy. Eighty-three patients, undergoing screening colonoscopy at an urban Veterans Affairs and university hospital, completed a questionnaire concerning alcohol, nonsteroidal anti-inflammatory drug (NSAID), and tobacco use. Folate intake was calculated from food frequency questionnaires. Rectal ACFs were scored using magnification chromoendoscopy (magnification, 35 x) by methylene blue staining. Folate concentrations in rectal biopsy specimens were determined by microtiter bioassay. ACF number increased with age and with increasing tobacco intake. Decreased colonic folate level was associated with increased homocysteine levels and lower dietary folate intake but did not correlate with ACF number. Increasing age and tobacco use were linked independently to the presence of colonic ACF in this predominantly African-American population. Folate, alcohol, and acetylsalicylic acid (ASA) use did not influence the prevalence of these lesions. JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association AU - Moxon, Darran AU - Raza, Mamoon AU - Kenney, Richard AU - Ewing, Ronald AU - Arozullah, Ahsan AU - Mason, Joel B AU - Carroll, Robert E AD - Department of Medicine, University of Illinois at Chicago and Chicago Veterans Administration Medical Center, Chicago, Illinois 60612, USA. Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 271 EP - 278 VL - 3 IS - 3 SN - 1542-3565, 1542-3565 KW - Index Medicus KW - Aging -- physiology KW - Folic Acid Deficiency -- complications KW - Colonoscopy KW - Humans KW - Smoking -- adverse effects KW - Intestinal Mucosa -- pathology KW - Aged KW - African Americans KW - Urban Population KW - Tobacco Use Disorder -- complications KW - Male KW - Female KW - Colonic Neoplasms -- etiology KW - Precancerous Conditions -- etiology KW - Precancerous Conditions -- diagnosis KW - Colonic Neoplasms -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67513775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+gastroenterology+and+hepatology+%3A+the+official+clinical+practice+journal+of+the+American+Gastroenterological+Association&rft.atitle=Relationship+of+aging+and+tobacco+use+with+the+development+of+aberrant+crypt+foci+in+a+predominantly+African-American+population.&rft.au=Moxon%2C+Darran%3BRaza%2C+Mamoon%3BKenney%2C+Richard%3BEwing%2C+Ronald%3BArozullah%2C+Ahsan%3BMason%2C+Joel+B%3BCarroll%2C+Robert+E&rft.aulast=Moxon&rft.aufirst=Darran&rft.date=2005-03-01&rft.volume=3&rft.issue=3&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Clinical+gastroenterology+and+hepatology+%3A+the+official+clinical+practice+journal+of+the+American+Gastroenterological+Association&rft.issn=15423565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-28 N1 - Date created - 2005-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sleep attacks in patients receiving dopamine-receptor agonists. AN - 67485444; 15745920 JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Plowman, Brian K AU - Boggie, Daniel T AU - Morreale, Anthony P AU - Schaefer, Monica G AU - Delattre, Melissa L AU - Chan, Henry AD - Veterans Affairs San Diego Healthcare System (VASDHS), San Diego, CA 92161, USA. brian.plowman@med.va.gov Y1 - 2005/03/01/ PY - 2005 DA - 2005 Mar 01 SP - 537 EP - 540 VL - 62 IS - 5 SN - 1079-2082, 1079-2082 KW - Benzothiazoles KW - 0 KW - Dopamine Agonists KW - Indoles KW - Thiazoles KW - ropinirole KW - 030PYR8953 KW - Pergolide KW - 24MJ822NZ9 KW - pramipexole KW - 83619PEU5T KW - Index Medicus KW - Pergolide -- adverse effects KW - Pergolide -- therapeutic use KW - Humans KW - Indoles -- adverse effects KW - Indoles -- therapeutic use KW - Aged KW - Middle Aged KW - Thiazoles -- adverse effects KW - Thiazoles -- therapeutic use KW - Male KW - Female KW - Dopamine Agonists -- therapeutic use KW - Restless Legs Syndrome -- drug therapy KW - Dopamine Agonists -- adverse effects KW - Parkinson Disease -- drug therapy KW - Narcolepsy -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67485444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Sleep+attacks+in+patients+receiving+dopamine-receptor+agonists.&rft.au=Plowman%2C+Brian+K%3BBoggie%2C+Daniel+T%3BMorreale%2C+Anthony+P%3BSchaefer%2C+Monica+G%3BDelattre%2C+Melissa+L%3BChan%2C+Henry&rft.aulast=Plowman&rft.aufirst=Brian&rft.date=2005-03-01&rft.volume=62&rft.issue=5&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-14 N1 - Date created - 2005-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Personality and comorbidity of common psychiatric disorders. AN - 67471266; 15738498 AB - We know little about the degree to which comorbidity, socommonly seen among psychiatric disorders, arises from variation in normal personality. To study the degree to which variation in normal personality accounts for the comorbidity of eight common psychiatric and substance use disorders. Internalising disorders (major depression, generalised anxiety and panic disorders, phobias), externalising disorders (alcohol and drug dependence, antisocial personality and conduct disorders) and personality dimensions of neuroticism, extraversion and novelty seeking were assessed in 7588 participants from a population-based twin registry. The proportion of comorbidity explained by each personality dimension was calculated using structural equation modelling. Neuroticism accounted for the highest proportion of comorbidity within internalising disorders (20-45%) and between internalising and externalising disorders (19-88%). Variation in neuroticism and novelty seeking each accounted for a modest proportion (10-12% and 7-14%, respectively) of the comorbidity within externalising disorders. Extraversion contributed negligibly. High neuroticism appears to be a broad vulnerability factor for comorbid psychiatric disorders. Novelty seeking is modestly important for comorbid externalising disorders. JF - The British journal of psychiatry : the journal of mental science AU - Khan, Amir A AU - Jacobson, Kristen C AU - Gardner, Charles O AU - Prescott, Carol A AU - Kendler, Kenneth S AD - Mental Health and Behavioral Sciences Service, Providence VA Medical Center, 830 Chalkstone Ave., Providence, RI 02908, USA. amir.khan2@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 190 EP - 196 VL - 186 SN - 0007-1250, 0007-1250 KW - Index Medicus KW - Sex Factors KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Exploratory Behavior KW - Neurotic Disorders -- epidemiology KW - Comorbidity KW - Logistic Models KW - Virginia -- epidemiology KW - Adult KW - Middle Aged KW - Female KW - Male KW - Substance-Related Disorders -- epidemiology KW - Prevalence KW - Mental Disorders -- epidemiology KW - Personality KW - Diseases in Twins -- epidemiology KW - Mental Disorders -- psychology KW - Diseases in Twins -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67471266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+journal+of+psyc