TY - JOUR T1 - Rotating methadone to other opioids: a lesson in the mechanisms of opioid tolerance and opioid-induced pain. AN - 67891475; 16629581 JF - Journal of palliative medicine AU - Prommer, Eric AD - UCLA School of Medicine, Division of Hematology/Oncology, VIP Palliative Care Program, Greater Los Angeles Healthcare, 90073, USA. Eric.prommer@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 488 EP - 493 VL - 9 IS - 2 SN - 1096-6218, 1096-6218 KW - Narcotics KW - 0 KW - Receptors, N-Methyl-D-Aspartate KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - United States KW - Drug Tolerance KW - Humans KW - Adult KW - Hyperalgesia KW - Male KW - Methadone -- therapeutic use KW - Pain -- chemically induced KW - Narcotics -- therapeutic use KW - Narcotics -- adverse effects KW - Narcotics -- administration & dosage KW - Narcotics -- poisoning KW - Methadone -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67891475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+palliative+medicine&rft.atitle=Rotating+methadone+to+other+opioids%3A+a+lesson+in+the+mechanisms+of+opioid+tolerance+and+opioid-induced+pain.&rft.au=Prommer%2C+Eric&rft.aulast=Prommer&rft.aufirst=Eric&rft.date=2006-04-01&rft.volume=9&rft.issue=2&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Journal+of+palliative+medicine&rft.issn=10966218&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-12 N1 - Date created - 2006-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk of mortality associated with antipsychotic and other neuropsychiatric drugs in pneumonia patients. AN - 67887401; 16633149 AB - To evaluate the use of typical and atypical antipsychotic medications and associated in-hospital mortality in a group of Veterans Administration (VA) patients with pneumonia. Our cohort consisted of 14,057 VA patients admitted for pneumonia in fiscal year (FY) 2003. Exposure to typical and atypical antipsychotics and other neuropsychiatric drugs was based on a prescription within 120 days preceding admission. Multivariate models determined the odds of mortality associated with each drug class and risk adjusted for comorbidity, admission source, demographic factors, and concurrent mental health conditions. The referent group for each analysis was pneumonia patients not receiving neuropsychiatric drugs. In adjusted analyses, the odds of in-hospital mortality for VA patients admitted with pneumonia was higher for recent exposure to typical antipsychotics (OR = 1.51, 95% CI = 1.04-2.19; P = 0.03) when compared to patients not receiving neuropsychiatric medications. Patients exposed to atypical antipsychotics (OR = 1.20, 95% CI = 0.96-1.50, P = .10), tricyclic antidepressants (OR = 1.20, 95% CI = 0.44-1.55; P = 0.15), other antidepressants (OR = 1.07, 95% CI = 0.93-1.23; P = 0.37), or mood stabilizers (OR = 0.91, 95% CI = 0.73-1.14; P = 0.41) had no significant difference in in-hospital mortality. In spite of recent safety concerns for atypical antipsychotics, we found no increased risk of mortality in acutely ill pneumonia patients. Rather, we found a higher adjusted mortality rate for patients taking typical antipsychotics. The contrasting mortality risks for patients taking typical and atypical antipsychotics may represent unmeasured severity of illness or comorbidity. Regardless, any antipsychotics should be used with caution and the efficacy and safety of alternative agents should be considered. JF - Journal of clinical psychopharmacology AU - Barnett, Mitchell J AU - Perry, Paul J AU - Alexander, Bruce AU - Kaboli, Peter J AD - The Center for Research in the Implementation of Innovative Strategies in Practice, Iowa City Veterans Administration Hospital, Iowa City, IA 52246, USA. barnettm@mail.medicine.uiowa.edu Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 182 EP - 187 VL - 26 IS - 2 SN - 0271-0749, 0271-0749 KW - Antidepressive Agents, Tricyclic KW - 0 KW - Antipsychotic Agents KW - Tranquilizing Agents KW - Index Medicus KW - United States KW - Length of Stay KW - United States Department of Veterans Affairs KW - Risk Factors KW - Humans KW - Hospital Mortality KW - Cohort Studies KW - Aged KW - Male KW - Female KW - Survival Analysis KW - Pneumonia -- mortality KW - Antipsychotic Agents -- therapeutic use KW - Antidepressive Agents, Tricyclic -- therapeutic use KW - Antidepressive Agents, Tricyclic -- adverse effects KW - Tranquilizing Agents -- therapeutic use KW - Tranquilizing Agents -- adverse effects KW - Pneumonia -- drug therapy KW - Antipsychotic Agents -- adverse effects KW - Health Services for the Aged UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67887401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Risk+of+mortality+associated+with+antipsychotic+and+other+neuropsychiatric+drugs+in+pneumonia+patients.&rft.au=Barnett%2C+Mitchell+J%3BPerry%2C+Paul+J%3BAlexander%2C+Bruce%3BKaboli%2C+Peter+J&rft.aulast=Barnett&rft.aufirst=Mitchell&rft.date=2006-04-01&rft.volume=26&rft.issue=2&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-04 N1 - Date created - 2006-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Case report: lack of control of diabetes and weight gain in a patient on initiation and rechallenge of therapy with olanzapine. AN - 67881348; 16623611 AB - The following is a case report analysis intended to draw attention to the need for better care coordination by describing the observed relationship of olanzapine to metabolic changes manifested as uncontrolled diabetes mellitus and weight gain. A 47-year-old male with bipolar I disorder/hallucinations presented to the Veterans Affairs Medical Center (VAMC) with suicidal ideations. He was referred to the psychiatry service where he was treated with olanzapine. He was followed exclusively by the psychiatry service for more than a year. During that time,weight issues and diabetes status were not addressed. Upon presenting to the primary care service a year and a half later, the patient was taking 40 mg per day of olanzapine and had gained 62 pounds, a 30% increase in body weight; glycosylated hemoglobin (A1c) was 11.1%. The patient was enrolled in a weight-loss clinic, and his diabetes medications were adjusted.Subsequently, olanzapine was discontinued because of weight gain and uncontrolled diabetes. Blood sugar and A1c were finally stabilized one month after discontinuation of olanzapine (A1c,6.9%). The patient experienced a relapse in his bipolar disorder,and olanzapine was restarted at 20 to 40 mg per day. His blood sugar became uncontrolled, he gained 13 pounds, and his A1c increased to 9.4%. JF - Journal of managed care pharmacy : JMCP AU - Schwetschenau, Kristen H AD - Department of Veterans Affairs, Cincinnati, OH 45220, USA. Kristen.Schwetschenau@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 260 EP - 262 VL - 12 IS - 3 SN - 1083-4087, 1083-4087 KW - Antipsychotic Agents KW - 0 KW - Hypoglycemic Agents KW - Benzodiazepines KW - 12794-10-4 KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - Hypoglycemic Agents -- therapeutic use KW - Benzodiazepines -- adverse effects KW - Humans KW - Middle Aged KW - Male KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Weight Gain -- drug effects KW - Hyperglycemia -- chemically induced KW - Diabetes Mellitus, Type 2 -- complications KW - Bipolar Disorder -- drug therapy KW - Antipsychotic Agents -- adverse effects KW - Bipolar Disorder -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67881348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+managed+care+pharmacy+%3A+JMCP&rft.atitle=Case+report%3A+lack+of+control+of+diabetes+and+weight+gain+in+a+patient+on+initiation+and+rechallenge+of+therapy+with+olanzapine.&rft.au=Schwetschenau%2C+Kristen+H&rft.aulast=Schwetschenau&rft.aufirst=Kristen&rft.date=2006-04-01&rft.volume=12&rft.issue=3&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Journal+of+managed+care+pharmacy+%3A+JMCP&rft.issn=10834087&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-22 N1 - Date created - 2006-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Black patients with chronic hepatitis C have a lower sustained viral response rate than non-Blacks with genotype 1, but the same with genotypes 2/3, and this is not explained by more frequent dose reductions of interferon and ribavirin*. AN - 67862466; 16611190 AB - In previous hepatitis C virus (HCV) treatment studies, Black patients not only had a lower sustained viral response (SVR) rate to interferon and ribavirin (RBV) than non-Black patients but also a higher frequency of HCV genotype 1 (GT-1) infection. The aim of this community-based study was to determine whether Black patients have a lower SVR rate independent of genotype. We prospectively enrolled 785 patients (24.8% Black, 71.5% White, 3.7% others) who received interferon alpha-2b 3 MU three times weekly + RBV 1000-1200 mg/day for 24 weeks (GT-2/3) or 48 weeks (GT-1). Black patients were more commonly infected with GT-1 (86.8%vs 64.8%, P < 0.001) and less frequently had an SVR compared with non-Black patients (8.4%vs 21.6%, P < 0.001). Within GT-1, Black patients had a lower SVR rate than non-Black patients (6.1%vs 14.1%, P = 0.004) but not within GT-2/3 (50.0%vs 36.5%, P = 0.47). Black patients had lower baseline haemoglobin levels (14.8 vs 15.3 g/dL, P < 0.001) and neutrophil counts (2900 vs 4100/mm(3), P < 0.001) and required more frequent dose reductions of RBV (29.8%vs 18.5%, P < 0.001) and interferon (4.7%vs 1.6%, P = 0.012). However, dose reductions were not associated with lower SVR rates while early treatment discontinuations were (2.9%vs 25.7%, P < 0.001). Independent predictors of SVR were GT-1 [odds ratio (OR) 0.33; 95% confidence interval (CI) 0.20-0.55; P < 0.001], Black race (OR 0.45; 95% CI 0.22-0.93; P = 0.030), and advanced fibrosis, stages 3 + 4 (OR 0.53; 95% CI 0.31-0.92; P = 0.023). In conclusion, Black patients infected with HCV GT-1 (but not GT-2/3) have a lower SVR rate than non-Black patients. This is not explained by their lower baseline haemoglobin levels and neutrophil counts that lead to higher rates of ribavirin and interferon dose reductions. JF - Journal of viral hepatitis AU - Bräu, N AU - Bini, E J AU - Currie, S AU - Shen, H AU - Schmidt, W N AU - King, P D AU - Ho, S B AU - Cheung, R C AU - Hu, K-Q AU - Anand, B S AU - Simon, F R AU - Aytaman, A AU - Johnson, D P AU - Awad, J A AU - Ahmad, J AU - Mendenhall, C L AU - Pedrosa, M C AU - Moseley, R H AU - Hagedorn, C H AU - Waters, B AU - Chang, K-M AU - Morgan, T R AU - Rossi, S J AU - Jeffers, L J AU - Wright, T L AU - VA-HCV-001 Study Group AD - Veteran Affairs Medical Centers, Bronx, NY 10468, USA. norbert.brau@med.va.gov ; VA-HCV-001 Study Group Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 242 EP - 249 VL - 13 IS - 4 SN - 1352-0504, 1352-0504 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - RNA, Viral KW - Ribavirin KW - 49717AWG6K KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Liver Cirrhosis -- pathology KW - Dose-Response Relationship, Drug KW - Humans KW - Biopsy KW - Multivariate Analysis KW - Genotype KW - Alanine Transaminase -- blood KW - Prospective Studies KW - Logistic Models KW - European Continental Ancestry Group KW - Middle Aged KW - Female KW - Male KW - RNA, Viral -- blood KW - Antiviral Agents -- administration & dosage KW - Interferon-alpha -- adverse effects KW - Interferon-alpha -- administration & dosage KW - Hepatitis C, Chronic -- blood KW - Hepacivirus -- genetics KW - Hepatitis C, Chronic -- drug therapy KW - Hepatitis C, Chronic -- virology KW - Ribavirin -- administration & dosage KW - Antiviral Agents -- adverse effects KW - African Continental Ancestry Group KW - Ribavirin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67862466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+viral+hepatitis&rft.atitle=Black+patients+with+chronic+hepatitis+C+have+a+lower+sustained+viral+response+rate+than+non-Blacks+with+genotype+1%2C+but+the+same+with+genotypes+2%2F3%2C+and+this+is+not+explained+by+more+frequent+dose+reductions+of+interferon+and+ribavirin*.&rft.au=Br%C3%A4u%2C+N%3BBini%2C+E+J%3BCurrie%2C+S%3BShen%2C+H%3BSchmidt%2C+W+N%3BKing%2C+P+D%3BHo%2C+S+B%3BCheung%2C+R+C%3BHu%2C+K-Q%3BAnand%2C+B+S%3BSimon%2C+F+R%3BAytaman%2C+A%3BJohnson%2C+D+P%3BAwad%2C+J+A%3BAhmad%2C+J%3BMendenhall%2C+C+L%3BPedrosa%2C+M+C%3BMoseley%2C+R+H%3BHagedorn%2C+C+H%3BWaters%2C+B%3BChang%2C+K-M%3BMorgan%2C+T+R%3BRossi%2C+S+J%3BJeffers%2C+L+J%3BWright%2C+T+L%3BVA-HCV-001+Study+Group&rft.aulast=Br%C3%A4u&rft.aufirst=N&rft.date=2006-04-01&rft.volume=13&rft.issue=4&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Journal+of+viral+hepatitis&rft.issn=13520504&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-06 N1 - Date created - 2006-04-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A randomized clinical trial of a new behavioral treatment for drug abuse in people with severe and persistent mental illness. AN - 67828892; 16585472 AB - Drug abuse by people with severe mental disorder is a significant public health problem for which there is no empirically validated treatment. To evaluate the efficacy of a new behavioral treatment for drug abuse in this population: Behavioral Treatment for Substance Abuse in Severe and Persistent Mental Illness (BTSAS). Participants were randomly assigned to 6 months of treatment in either BTSAS or a manualized control condition: Supportive Treatment for Addiction Recovery (STAR). Treatment was conducted in community-based outpatient clinics and a Veterans Affairs medical center in Baltimore, Md. Participants were 129 stabilized outpatients meeting DSM criteria for drug dependence (cocaine, heroin, or cannabis) and serious mental illness: 39.5% met DSM-IV criteria for schizophrenia or schizoaffective disorder; 55.8%, for major affective disorders; and the remainder met criteria for severe and persistent mental illness and other Axis I disorders. Both treatments were administered by trained health care professionals in small groups, twice a week for 6 months. The BTSAS program is a social learning intervention that includes motivational interviewing, a urinalysis contingency, and social skills training. The control condition, STAR, is a supportive group discussion treatment. Main Outcome Measure The primary outcome measure was urinalysis results from twice-weekly treatment sessions. The BTSAS program was significantly more effective than STAR in percentage of clean urine test results, survival in treatment, and attendance at sessions. The BTSAS program also had significant effects on important community-functioning variables, including hospitalization; money available for living expenses; and quality of life. The BTSAS program is an efficacious treatment. Further work needs to be done to increase the proportion of eligible patients who are able to become engaged in treatment. JF - Archives of general psychiatry AU - Bellack, Alan S AU - Bennett, Melanie E AU - Gearon, Jean S AU - Brown, Clayton H AU - Yang, Ye AD - University of Maryland School of Medicine and Veterans Affairs Capitol Health Care Network Mental Illness Research, Education, Baltimore, 21201, USA. alan.bellack@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 426 EP - 432 VL - 63 IS - 4 SN - 0003-990X, 0003-990X KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Depressive Disorder, Major -- diagnosis KW - Psychotic Disorders -- therapy KW - Humans KW - Schizophrenia -- diagnosis KW - Diagnosis, Dual (Psychiatry) KW - Quality of Life KW - Depressive Disorder, Major -- epidemiology KW - Depressive Disorder, Major -- therapy KW - Outcome Assessment (Health Care) KW - Schizophrenia -- therapy KW - Psychotic Disorders -- epidemiology KW - Community Mental Health Services KW - Comorbidity KW - Ambulatory Care KW - Psychotherapy, Group KW - Psychiatric Status Rating Scales KW - Substance Abuse Detection KW - Treatment Outcome KW - Middle Aged KW - Schizophrenia -- epidemiology KW - Psychotic Disorders -- diagnosis KW - Female KW - Male KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Mental Disorders -- diagnosis KW - Mental Disorders -- epidemiology KW - Behavior Therapy -- methods KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67828892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=A+randomized+clinical+trial+of+a+new+behavioral+treatment+for+drug+abuse+in+people+with+severe+and+persistent+mental+illness.&rft.au=Bellack%2C+Alan+S%3BBennett%2C+Melanie+E%3BGearon%2C+Jean+S%3BBrown%2C+Clayton+H%3BYang%2C+Ye&rft.aulast=Bellack&rft.aufirst=Alan&rft.date=2006-04-01&rft.volume=63&rft.issue=4&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-11 N1 - Date created - 2006-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Randomized trial of onsite versus referral primary medical care for veterans in addictions treatment. AN - 67799653; 16565634 AB - Patients presenting for treatment of substance use disorders (SUDs) often exhibit medical comorbidities that affect functional health status and healthcare costs. Providing primary care within addictions clinics (onsite care) may improve medical and SUD treatment outcomes in this population. The objective of this study was to compare outcomes among Veterans' Administration (VA) patients who receive medical care within the SUD clinic and those referred to a general medicine clinic at the same facility. Veterans entering SUD treatment with a chronic medical condition and no current primary care were randomized to receive primary medical care: 1) onsite in the VA SUD clinic (n = 358), or 2) in the VA general internal medicine clinic (n = 362). Subjects were assessed at baseline and at 3, 6, and 12 months postrandomization. Intention-to-treat analyses used random-effects regression. Measures included SF-36 Physical and Mental Component Summaries (PCS, MCS), VA service utilization, SUD treatment retention, Addiction Severity Index (ASI) scores, 30-day abstinence, and total VA healthcare costs. Over the study year, patients assigned to onsite care were more likely to attend primary care (adjusted odds ratio [OR] = 2.20; 95% confidence interval [CI] = 1.53-3.15) and to remain engaged in SUD treatment at 3 months (adjusted OR = 1.36; 1.00-1.84). Overall, outcomes on the MCS (but not the PCS) and the ASI improved significantly over time but did not differ by treatment condition. Total VA healthcare costs did not differ reliably across conditions. Compared with referral care, providing primary care within a VA addiction clinic increased primary care access and initial SUD treatment retention but showed no effect on overall health status or costs. JF - Medical care AU - Saxon, Andrew J AU - Malte, Carol A AU - Sloan, Kevin L AU - Baer, John S AU - Calsyn, Donald A AU - Nichol, Paul AU - Chapko, Michael K AU - Kivlahan, Daniel R AD - VA Puget Sound Health Care System, Seattle, Washington 98108, USA. Andrew.Saxon@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 334 EP - 342 VL - 44 IS - 4 SN - 0025-7079, 0025-7079 KW - Index Medicus KW - Continuity of Patient Care -- organization & administration KW - Odds Ratio KW - Washington KW - Humans KW - Internal Medicine KW - Outcome Assessment (Health Care) KW - Comorbidity KW - Patient Satisfaction -- statistics & numerical data KW - Patient Compliance KW - Adult KW - Treatment Outcome KW - Confidence Intervals KW - Middle Aged KW - Female KW - Male KW - Substance-Related Disorders -- therapy KW - Primary Health Care -- utilization KW - Veterans -- psychology KW - Referral and Consultation KW - Hospitals, Veterans -- organization & administration KW - Substance-Related Disorders -- economics KW - Substance Abuse Treatment Centers -- economics KW - Hospitals, Veterans -- utilization KW - Substance Abuse Treatment Centers -- utilization KW - Primary Health Care -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67799653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=Randomized+trial+of+onsite+versus+referral+primary+medical+care+for+veterans+in+addictions+treatment.&rft.au=Saxon%2C+Andrew+J%3BMalte%2C+Carol+A%3BSloan%2C+Kevin+L%3BBaer%2C+John+S%3BCalsyn%2C+Donald+A%3BNichol%2C+Paul%3BChapko%2C+Michael+K%3BKivlahan%2C+Daniel+R&rft.aulast=Saxon&rft.aufirst=Andrew&rft.date=2006-04-01&rft.volume=44&rft.issue=4&rft.spage=334&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=00257079&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-27 N1 - Date created - 2006-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sweet intake, sweet-liking, urges to eat, and weight change: relationship to alcohol dependence and abstinence. AN - 67780176; 15990241 AB - Linkages between alcohol dependence (AD) and abstinence and aspects of food ingestion and preference have been described in animals and humans, including (1) eating sweets decreases urges to drink alcohol; (2) preferences for highly sweet tastants is associated with alcohol dependence; and (3) food deprivation leads to increased alcohol intake. We randomly assigned AD subjects in early abstinence to 3 different sets of dietary instructions (eat sweets for alcohol urges; eat a balanced diet; avoid sweets). We compared the groups on urges for alcohol, alcohol consumption, weight, and sweet preference at baseline, one, and six months. We also compared these AD subjects with light-drinking C's and compared AD subjects who remained abstinent for 6 month follow-up with nonabstinent AD subjects. Recruited AS subjects, 38 of 68, completed 6 month follow-up; 27 of 36 C's completed the follow-up. 21 AD's were abstinent while 17 were non-abstinent. There was no effect of dietary recommendations on urges to drink or alcohol consumption. AD's were more likely than C's to prefer highly sweet tastants. The proportion of AD's preferring the sweetest tastant decreased over time. AD's gained more weight than C's over the 6-month follow-up. While the use of sweets did not affect urges to drink or drinking, important relationships between sweet preference, weight gain, and alcohol dependence or abstinence were identified. JF - Addictive behaviors AU - Krahn, Dean AU - Grossman, Jennifer AU - Henk, Henry AU - Mussey, Mary AU - Crosby, Ross AU - Gosnell, Blake AD - Wm. S. Middleton Memorial Veterans Hospital, Psychiatry Service, 2500 Overlook Terrace, and University of Wisconsin Medical School, Madison, Wisconsin 53705, United States. dean.krahn@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 622 EP - 631 VL - 31 IS - 4 SN - 0306-4603, 0306-4603 KW - Dietary Sucrose KW - 0 KW - Sucrose KW - 57-50-1 KW - Index Medicus KW - Food Preferences -- psychology KW - Motivation KW - Humans KW - Aged KW - Taste KW - Appetite KW - Dietary Sucrose -- administration & dosage KW - Adult KW - Temperance -- psychology KW - Alcohol Drinking -- physiopathology KW - Alcohol Drinking -- psychology KW - Middle Aged KW - Sucrose -- administration & dosage KW - Male KW - Diet -- psychology KW - Candy KW - Eating -- psychology KW - Alcoholism -- physiopathology KW - Weight Gain -- physiology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67780176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Sweet+intake%2C+sweet-liking%2C+urges+to+eat%2C+and+weight+change%3A+relationship+to+alcohol+dependence+and+abstinence.&rft.au=Krahn%2C+Dean%3BGrossman%2C+Jennifer%3BHenk%2C+Henry%3BMussey%2C+Mary%3BCrosby%2C+Ross%3BGosnell%2C+Blake&rft.aulast=Krahn&rft.aufirst=Dean&rft.date=2006-04-01&rft.volume=31&rft.issue=4&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-05 N1 - Date created - 2006-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Majority of patients with hepatitis C express physical, mental, and social difficulties with antiviral treatment. AN - 67749863; 16538109 AB - The hepatitis C virus can be successfully treated in up to 60% of infected patients. However, treatment is long and is associated with significant side-effects. We investigated difficulties with this treatment as it is an important factor in patient adherence. Patients receiving hepatitis C treatment in a tertiary referral center were enrolled in a cross-sectional study. Demographic data, functional and emotional status, and co-morbidities were collected from patients or abstracted from the medical records. All participants underwent a semistructured interview, which was analysed by blinded coders. A total of 65 patients (mean age 46.1 years; 38.5% women) were enrolled. Fifty-two (80%) described moderate to severe problems attributed to treatment, with a predominance of physical difficulties (fatigue 74% of cases; flu-like symptoms 32%). Approximately one third of patients (38%) experienced depression during treatment. In 31% of cases, physical or emotional problems forced patients to quit their jobs or reduce employment. One fifth attributed deteriorating relationships with friends and family to adverse treatment effects. Necessary lifestyle adjustments, such as alcohol abstinence, caused frictions with friends in 22% of the participants. Our findings show a high prevalence of significant adverse effects in patients undergoing antiviral therapy. Whereas the nature and severity of these adverse reactions is consistent with earlier reports, we identified implications with worsening private and professional relationships. To encourage appropriate levels of adherence, healthcare providers should seek information about these indirect treatment effects as they monitor their patients on therapy. JF - European journal of gastroenterology & hepatology AU - Zickmund, Susan L AU - Bryce, Cindy L AU - Blasiole, Julie A AU - Shinkunas, Laura AU - LaBrecque, Douglas R AU - Arnold, Robert M AD - Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. susan.zickmund@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 381 EP - 388 VL - 18 IS - 4 SN - 0954-691X, 0954-691X KW - Antiviral Agents KW - 0 KW - Index Medicus KW - Analysis of Variance KW - Humans KW - Interpersonal Relations KW - Activities of Daily Living KW - Quality of Life -- psychology KW - Comorbidity KW - Cross-Sectional Studies KW - Patient Compliance KW - Adult KW - Middle Aged KW - Midwestern United States KW - Female KW - Male KW - Prevalence KW - Depression -- etiology KW - Hepatitis C, Chronic -- psychology KW - Hepatitis C, Chronic -- drug therapy KW - Hepatitis C, Chronic -- complications KW - Fatigue -- etiology KW - Antiviral Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67749863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+gastroenterology+%26+hepatology&rft.atitle=Majority+of+patients+with+hepatitis+C+express+physical%2C+mental%2C+and+social+difficulties+with+antiviral+treatment.&rft.au=Zickmund%2C+Susan+L%3BBryce%2C+Cindy+L%3BBlasiole%2C+Julie+A%3BShinkunas%2C+Laura%3BLaBrecque%2C+Douglas+R%3BArnold%2C+Robert+M&rft.aulast=Zickmund&rft.aufirst=Susan&rft.date=2006-04-01&rft.volume=18&rft.issue=4&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=European+journal+of+gastroenterology+%26+hepatology&rft.issn=0954691X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-09 N1 - Date created - 2006-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An emerging role for calcineurin Aalpha in the development and function of the kidney. AN - 67731577; 16527922 AB - For many years, calcineurin has been a familiar molecule as a target of the immunosuppressive agents cyclosporin A and FK-506. Calcineurin inhibition interferes with T cell signaling by preventing activation of the transcription factor NFATc. However, calcineurin is expressed in most tissues in the body, and calcineurin inhibition undoubtedly alters many other cellular processes. As a result, serious side effects of calcineurin inhibitors regularly occur, including hypertension and renal dysfunction. Because nephrotoxicity is often a barrier to continued clinical use of calcineurin inhibitors, understanding the role of calcineurin in the kidney is of particular importance. Recent work has demonstrated that the two main isoforms of the catalytic subunit of calcineurin, Aalpha and Abeta, may have distinct functions, particularly in the kidney. Calcineurin isoforms may be differentially expressed, and/or the activity of each may be differentially regulated, leading to tissue-specific functions. Differences between the action of the two isoforms are most evident in knockout mice lacking each isoform. Mice lacking the beta-isoform are characterized principally by altered development and function of immune cells. alpha-Knockout mice, in contrast, can still be immune suppressed by cyclosporin A but display pervasive developmental defects, including renal dysfunction. Therefore, it is intriguing to consider that while the beta-isoform may be responsible for calcineurin action in T cells, the alpha-isoform may be the predominant catalytic isoform in the kidney. This conclusion, if correct, may have substantial clinical implication for novel strategies to selectively target calcineurin action in T cells without associated nephrotoxicity. JF - American journal of physiology. Renal physiology AU - Gooch, Jennifer L AD - Department of Medicine/Division of Nephrology, Emory University School of Medicine, and Atlanta Veterans Administration Medical Center, Atlanta, Georgia 30322, USA. jgooch@emory.edu Y1 - 2006/04// PY - 2006 DA - April 2006 SP - F769 EP - F776 VL - 290 IS - 4 SN - 1931-857X, 1931-857X KW - Calcineurin Inhibitors KW - 0 KW - Protein Isoforms KW - Calcineurin KW - EC 3.1.3.16 KW - Index Medicus KW - Animals KW - Humans KW - Molecular Sequence Data KW - Mice KW - Amino Acid Sequence KW - T-Lymphocytes KW - Mice, Knockout KW - Catalysis KW - Calcineurin -- physiology KW - Kidney -- growth & development KW - Kidney -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67731577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Renal+physiology&rft.atitle=An+emerging+role+for+calcineurin+Aalpha+in+the+development+and+function+of+the+kidney.&rft.au=Gooch%2C+Jennifer+L&rft.aulast=Gooch&rft.aufirst=Jennifer&rft.date=2006-04-01&rft.volume=290&rft.issue=4&rft.spage=F769&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Renal+physiology&rft.issn=1931857X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2006-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Does Expressive Writing Reduce Health Care Utilization? A Meta-Analysis of Randomized Trials AN - 57219766; 200612649 AB - This meta-analysis examined whether writing about stressful experiences affects health care utilization (HCU) compared with writing on neutral topics or no-writing control groups. Randomized controlled trials of 30 independent samples representing 2,294 participants were located that contained sufficient information to calculate effect sizes. After omitting one study as an outlier, the effects were combined within 3 homogeneous groups: healthy samples (13 studies), samples with preexisting medical conditions (6 studies), & samples prescreened for psychological criteria (10 studies). Combined effect sizes, Hedges's g (95% confidence interval), with random effects estimation were 0.16 (0.02, 0.31), 0.21 (-0.02, 0.43), & 0.06 (-0.12, 0.24), respectively. Writing about stressful experiences reduces HCU in healthy samples but not in samples defined by medical diagnoses or exposure to stress or other psychological factors. The significance of these effects for individuals' health is unknown. 4 Tables, 1 Figure, 53 References. [Copyright 2006 American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Harris, Alex H S AD - Center Health Care Evaluation, U.S. Dept Veterans Affairs, Menlo Park, CA Alexander.Harris2@va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 243 EP - 252 PB - American Psychological Association, Washington DC VL - 74 IS - 2 SN - 0022-006X, 0022-006X KW - writing, written expression, health care utilization, meta-analysis, health KW - Users KW - Health care KW - Writing KW - Meta-analysis KW - Stressful events KW - Health behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57219766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=Does+Expressive+Writing+Reduce+Health+Care+Utilization%3F+A+Meta-Analysis+of+Randomized+Trials&rft.au=Harris%2C+Alex+H+S&rft.aulast=Harris&rft.aufirst=Alex+H&rft.date=2006-04-01&rft.volume=74&rft.issue=2&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2F0022-006X.74.2.243 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Writing; Stressful events; Meta-analysis; Health behaviour; Health care; Users DO - http://dx.doi.org/10.1037/0022-006X.74.2.243 ER - TY - JOUR T1 - Taking Charge: A Pilot Curriculum of Self-Defense and Personal Safety Training for Female Veterans with PTSD Because of Military Sexual Trauma AN - 57110481; 200704592 AB - The authors describe an overview of the pilot project Taking Charge, a 36-hour comprehensive behavioral intervention involving psychoeducation, personal safety, & self-defense training for 12 female veterans with posttraumatic stress disorder (PTSD) from military sexual trauma. Self-defense training can incorporate the benefits of repeated exposure while teaching proactive cognitive & behavioral responses to the feared stimuli, & thus facilitate emotional & physical rescripting of & mastery over the trauma. Results up to 6 months follow-up indicate significant reductions in behavioral avoidance, PTSD hyperarousal, & depression, with significant increases in interpersonal, activity, & self-defense self-efficacy. The authors propose that this therapeutic self-defense curriculum provides an enhanced exposure therapy paradigm that may be a potent therapeutic tool in the treatment of PTSD. Tables, References. [Reprinted by permission of Sage Publications Inc., copyright 2006.] JF - Journal of Interpersonal Violence AU - David, Wendy S AU - Simpson, Tracy L AU - Cotton, Ann J AD - VA Puget Sound Health Care System, Seattle, WA wendy.david@med.va.gov Y1 - 2006/04// PY - 2006 DA - April 2006 SP - 555 EP - 565 PB - Sage Publications, Thousand Oaks CA VL - 21 IS - 4 SN - 0886-2605, 0886-2605 KW - posttraumatic stress disorder KW - women veterans KW - personal safety KW - self-defense KW - Veterans KW - Posttraumatic stress disorder KW - Exposure therapy KW - Behaviour therapy KW - Women KW - Selfdefence training KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57110481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interpersonal+Violence&rft.atitle=Taking+Charge%3A+A+Pilot+Curriculum+of+Self-Defense+and+Personal+Safety+Training+for+Female+Veterans+with+PTSD+Because+of+Military+Sexual+Trauma&rft.au=David%2C+Wendy+S%3BSimpson%2C+Tracy+L%3BCotton%2C+Ann+J&rft.aulast=David&rft.aufirst=Wendy&rft.date=2006-04-01&rft.volume=21&rft.issue=4&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interpersonal+Violence&rft.issn=08862605&rft_id=info:doi/10.1177%2F0886260505285723 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-05-30 N1 - Last updated - 2016-09-27 N1 - CODEN - JIVIEI N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Women; Veterans; Selfdefence training; Exposure therapy; Behaviour therapy DO - http://dx.doi.org/10.1177/0886260505285723 ER - TY - JOUR T1 - IL-4-Induced Peroxisome Proliferator-Activated Receptor gamma Activation Inhibits NF- Kappa B Trans Activation in Central Nervous System (CNS) Glial Cells and Protects Oligodendrocyte Progenitors under Neuroinflammatory Disease Conditions: Implication for CNS-Demyelinating Diseases AN - 20240986; 6748737 AB - Th2 phenotype cytokine, IL-4, plays an important role in the regulation of Th1 cell responses and spontaneous remission of inflammatory CNS demyelinating diseases such as multiple sclerosis (MS). In this study we demonstrate IL-4-induced down-regulation of inducible NO synthase (iNOS) expression and survival of differentiating oligodendrocyte progenitors (OPs) in proinflammatory cytokine (Cyt-Mix)-treated CNS glial cells, which is a condition similar to that observed in the brain of a patient with MS. IL-4 treatment of Cyt-Mix-treated CNS glial cells significantly decreased iNOS expression/NO release with a parallel increase in survival of differentiating OPs. IL-4 effects were concentration-dependent and could be reversed by anti-IL-4R Abs. The use of inhibitors for Akt, p38 MAPK, and peroxisome proliferator-activated receptor gamma (PPAR- gamma ) antagonist revealed that inhibition of Cyt-Mix-induced iNOS expression and survival of differentiating OPs by IL-4 is via PPAR- gamma activation. There was a coordinate increase in the expression of both PPAR- gamma and its natural ligand-producing enzyme 12/15-lipoxygenase (12/15-LOX) in IL-4-treated cells. Next, EMSA, immunoblots, and transient cotransfection studies with reporter plasmids (pNF- Kappa B-Luc and pTK-PPREx3-Luc) and 12/15-LOX small interfering RNA revealed that IL-4-induced PPAR- gamma activation antagonizes NF- Kappa B transactivation in Cyt-Mix-treated astrocytes. In support of this finding, similarly treated 12/15-LOX super(-/-) CNS glial cells further corroborated the result. Furthermore, there was reversal of IL-4 inductive effects in the brain of LPS-challenged 12/15-LOX super(-/-) mice when compared with LPS-challenged wild-type mice. Together, these data for the first time demonstrate the inhibition of Cyt-Mix-induced NF- Kappa B transactivation in CNS glial cells by IL-4 via PPAR- gamma activation, hence its implication for the protection of differentiating OPs during MS and other CNS demyelinating diseases. JF - Journal of Immunology AU - Paintlia, Ajaib S AU - Paintlia, Manjeet K AU - Singh, Inderjit AU - Singh, Avtar K AD - Department of Pediatrics and Department of Pathology and Laboratory Medicine, Medical University of South Carolina and Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC 29425 Y1 - 2006/04/01/ PY - 2006 DA - 2006 Apr 01 SP - 4385 EP - 4398 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 176 IS - 7 SN - 0022-1767, 0022-1767 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Cell survival KW - Central nervous system KW - Interleukin 4 KW - Astrocytes KW - Peroxisome proliferator-activated receptors KW - Oligodendrocytes KW - Glial cells KW - Helper cells KW - Arachidonate 12-lipoxygenase KW - Demyelinating diseases KW - NF- Kappa B protein KW - Glial stem cells KW - Inflammatory diseases KW - AKT protein KW - Lymphocytes T KW - MAP kinase KW - Data processing KW - Multiple sclerosis KW - Brain KW - Remission KW - Enzymes KW - Plasmids KW - Inflammation KW - Nitric-oxide synthase KW - siRNA KW - Nitric oxide KW - W 30940:Products KW - F 06326:Multiple Sclerosis: Clinical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20240986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=IL-4-Induced+Peroxisome+Proliferator-Activated+Receptor+gamma+Activation+Inhibits+NF-+Kappa+B+Trans+Activation+in+Central+Nervous+System+%28CNS%29+Glial+Cells+and+Protects+Oligodendrocyte+Progenitors+under+Neuroinflammatory+Disease+Conditions%3A+Implication+for+CNS-Demyelinating+Diseases&rft.au=Paintlia%2C+Ajaib+S%3BPaintlia%2C+Manjeet+K%3BSingh%2C+Inderjit%3BSingh%2C+Avtar+K&rft.aulast=Paintlia&rft.aufirst=Ajaib&rft.date=2006-04-01&rft.volume=176&rft.issue=7&rft.spage=4385&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Central nervous system; Interleukin 4; Oligodendrocytes; Peroxisome proliferator-activated receptors; Astrocytes; Helper cells; Glial cells; Arachidonate 12-lipoxygenase; Demyelinating diseases; NF- Kappa B protein; Glial stem cells; Inflammatory diseases; Lymphocytes T; AKT protein; MAP kinase; Data processing; Multiple sclerosis; Brain; Enzymes; Remission; Plasmids; Inflammation; Nitric-oxide synthase; siRNA; Nitric oxide ER - TY - JOUR T1 - Microarray analysis of gene expression during the inflammation and endochondral bone formation stages of rat femur fracture repair AN - 20078351; 6843080 AB - Microarray analysis of gene expression was performed in the healing femur fractures of 13-week-old male rats during the inflammatory stage of repair, at 3 days post-fracture, and the endochondral bone formation stage of repair, at 11 days post-fracture. Multiple replicate pairs of fracture tissues paired with unfractured tissues, and unfractured control bones that had the stabilizing K-wire were introduced. This approach normalized the marrow contributions to the RNA repertoire. We identified 6555 genes with significant changes in expression in fracture tissues at 3 days and 11 days healing. The repertoire of growth factor genes expressed was also surprisingly restricted at both post-fracture intervals. The large number of Expressed Sequence Tags (ESTs) expressed at both post-fracture times indicates that several molecular pathways yet to be identified regulate fracture repair. The number of genes expressed during immune responses and inflammatory processes was restricted with higher expression largely during the early post-fracture analysis. Several of the genes identified in this study have been associated with regulation of cell and extracellular matrix interactions during scarless healing of fetal skin wounds. These observations suggest that these genes might also regulate the scarless healing characteristic of bone regeneration by similar mechanisms. JF - Bone AU - Rundle, CH AU - Wang, H AU - Yu, H AU - Chadwick, R B AU - Davis, E I AU - Wergedal, JE AU - Lau, KHW AU - Mohan, S AU - Ryaby, J T AU - Baylink, D J AD - Jerry L. Pettis V. A. Medical Center, Loma Linda, CA 92357, USA, William.Lau@med.va.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 521 EP - 529 PB - Elsevier Inc. VL - 38 IS - 4 SN - 8756-3282, 8756-3282 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Skin KW - Fractures KW - Bone growth KW - Femur KW - expressed sequence tags KW - DNA microarrays KW - Fetuses KW - Inflammation KW - Wounds KW - Gene expression KW - Bone healing KW - RNA KW - Extracellular matrix KW - Regeneration KW - Growth factors KW - Immune response KW - Osteogenesis KW - T 20031:Fractures and bone healing KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20078351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bone&rft.atitle=Microarray+analysis+of+gene+expression+during+the+inflammation+and+endochondral+bone+formation+stages+of+rat+femur+fracture+repair&rft.au=Rundle%2C+CH%3BWang%2C+H%3BYu%2C+H%3BChadwick%2C+R+B%3BDavis%2C+E+I%3BWergedal%2C+JE%3BLau%2C+KHW%3BMohan%2C+S%3BRyaby%2C+J+T%3BBaylink%2C+D+J&rft.aulast=Rundle&rft.aufirst=CH&rft.date=2006-04-01&rft.volume=38&rft.issue=4&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Bone&rft.issn=87563282&rft_id=info:doi/10.1016%2Fj.bone.2005.09.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Skin; Bone growth; Fractures; DNA microarrays; expressed sequence tags; Femur; Fetuses; Wounds; Inflammation; Bone healing; Gene expression; RNA; Extracellular matrix; Regeneration; Immune response; Growth factors; Osteogenesis DO - http://dx.doi.org/10.1016/j.bone.2005.09.015 ER - TY - JOUR T1 - Infectious arthritis: clinical features, laboratory findings and treatment AN - 19839662; 6761904 AB - An infection of native joints leads generally to suppurative arthritis, which may be of one joint (monarticular) or several joints (oligoarticular). Bacteria that produce symptoms in multiple joints during bacteraemia, such as Neisseria gonorrhoeae, may also induce inflammation in the neighbouring tendon sheaths. Viral infections frequently involve multiple joints and produce inflammation without suppuration. Chronic granulomatous monarticular arthritis may occur because of infection with either mycobacteria or fungi, which must be differentiated from other causes of chronic monarticular arthritis. A sterile arthritis may occur early in infection (as with hepatitis B), or later (as with a post-infectious arthritis). Any patient presenting with an inflamed joint should have infection as a diagnostic possibility and appropriate cultures must be performed. JF - Clinical Microbiology and Infection AU - Smith, J W AU - Chalupa, P AU - Shabaz Hasan, M AD - University of Texas Southwestern Medical Center Dallas, Department of Medicine, Division of Infectious Diseases, and North Texas Veterans Healthcare Systems, Dallas, TX, USA, jameswilliam.smith@med.va.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 309 EP - 314 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 12 IS - 4 SN - 1198-743X, 1198-743X KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Arthritis KW - bacterial infection KW - fungal infection KW - review KW - viral infection KW - Reviews KW - Fungi KW - Chronic infection KW - Joint diseases KW - Hepatitis B KW - Bacteremia KW - Sheaths KW - Neisseria gonorrhoeae KW - Tendons KW - Inflammation KW - J 02855:Human Bacteriology: Others KW - V 22350:Immunology KW - K 03400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19839662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+and+Infection&rft.atitle=Infectious+arthritis%3A+clinical+features%2C+laboratory+findings+and+treatment&rft.au=Smith%2C+J+W%3BChalupa%2C+P%3BShabaz+Hasan%2C+M&rft.aulast=Smith&rft.aufirst=J&rft.date=2006-04-01&rft.volume=12&rft.issue=4&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+and+Infection&rft.issn=1198743X&rft_id=info:doi/10.1111%2Fj.1469-0691.2006.01366.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - SuppNotes - Tables, 5; references, 24. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Fungi; Reviews; Arthritis; Chronic infection; Hepatitis B; Joint diseases; Bacteremia; Sheaths; Tendons; Inflammation; Neisseria gonorrhoeae DO - http://dx.doi.org/10.1111/j.1469-0691.2006.01366.x ER - TY - JOUR T1 - Unmet medical needs in antibacterial therapy AN - 19769012; 6699430 AB - The innate and evolutionary resourcefulness of bacterial pathogens virtually guarantees that there will always be important areas in which antimicrobial therapy can be improved. Current areas of need, or ones that are anticipated to be problematic in the near future include nosocomial infections caused by multi- resistant Gram-negative bacteria, where the variety and prevalence of multidrug efflux pumps provides a particular challenge to the designers of new drugs. In the community setting, the current prevalence of ampicillin and trimethoprim- sulfamethoxazole resistance, and the growing prevalence of fluoroquinolone resistance in Escherichia coli portend a need for new classes of oral agents to address this important need. On the Gram-positive side, the rapid increase in virulent community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections as a cause of pneumonia emphasizes the importance of developing more agents that are active against MRSA and that are effective for treating pneumonia. Finally, the importance of indwelling devices as a nidus for nosocomial infections emphasizes the need for effective agents for treating biofilm-associated device infection both inside and outside of the hospital. JF - Biochemical Pharmacology AU - Rice, Louis B AD - Louis Stokes Cleveland VA Medical Center and Case Western Reserve University, Medical Service 111(W), 10701 East Blvd., Cleveland, OH 44106, USA, louis.rice@med.va.gov Y1 - 2006/03/30/ PY - 2006 DA - 2006 Mar 30 SP - 991 EP - 995 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 71 IS - 7 SN - 0006-2952, 0006-2952 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Antimicrobial agents KW - Efflux pumps KW - Porins KW - Biofilms KW - Resistance KW - Sulfamethoxazole KW - Fluoroquinolones KW - Drug resistance KW - Ampicillin KW - Pathogens KW - Gram-negative bacteria KW - Nosocomial infection KW - Escherichia coli KW - Staphylococcus aureus KW - Pneumonia KW - Evolution KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19769012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Pharmacology&rft.atitle=Unmet+medical+needs+in+antibacterial+therapy&rft.au=Rice%2C+Louis+B&rft.aulast=Rice&rft.aufirst=Louis&rft.date=2006-03-30&rft.volume=71&rft.issue=7&rft.spage=991&rft.isbn=&rft.btitle=&rft.title=Biochemical+Pharmacology&rft.issn=00062952&rft_id=info:doi/10.1016%2Fj.bcp.2005.09.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Fluoroquinolones; Sulfamethoxazole; Drug resistance; Gram-negative bacteria; Nosocomial infection; Ampicillin; Pathogens; Evolution; Pneumonia; Antimicrobial agents; Hospitals; Escherichia coli; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.bcp.2005.09.018 ER - TY - JOUR T1 - Sustained virological response rates and health-related quality of life after interferon and ribavirin therapy in patients with chronic hepatitis C virus infection and persistently normal alanine aminotransferase levels. AN - 67775667; 16556180 AB - Few studies have evaluated interferon and ribavirin therapy in hepatitis C virus-infected patients with persistently normal alanine aminotransferase (ALT) levels. To determine the efficacy and safety of combination therapy in this population, and to evaluate the impact of treatment on health-related quality of life. Forty-six hepatitis C virus-infected patients with persistently normal ALT levels and 92 matched subjects with elevated ALT levels were treated with interferon-alpha2b plus ribavirin for up to 48 weeks. Health-related quality of life was measured prior to therapy and 24 weeks after completion of treatment using the Hepatitis Quality of Life Questionnaire. Overall, 32.6% of patients with normal ALT levels and 28.3% of those with elevated ALT levels had undetectable hepatitis C virus RNA at 24 weeks after completion of treatment (P = 0.60). Three patients in the normal ALT group had mild transient ALT elevations during therapy. Compared with baseline, treatment was associated with significant improvements in nearly all domains of health-related quality of life in both groups of patients. In hepatitis C virus-infected patients with persistently normal ALT levels, interferon-alpha and ribavirin therapy is efficacious, safe, and associated with significant improvements in health-related quality of life. JF - Alimentary pharmacology & therapeutics AU - Bini, E J AU - Mehandru, S AD - Department of Medicine and Division of Gastroenterology, VA New York Harbor Healthcare System and NYU School of Medicine, New York, NY 10010, USA. edmund.bini@med.va.gov Y1 - 2006/03/15/ PY - 2006 DA - 2006 Mar 15 SP - 777 EP - 785 VL - 23 IS - 6 SN - 0269-2813, 0269-2813 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - RNA, Viral KW - Recombinant Proteins KW - interferon alfa-2b KW - 43K1W2T1M6 KW - Ribavirin KW - 49717AWG6K KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Genotype KW - Drug Therapy, Combination KW - Hepacivirus -- genetics KW - Humans KW - Hepacivirus -- isolation & purification KW - Treatment Outcome KW - Middle Aged KW - Male KW - Hepacivirus -- drug effects KW - Female KW - RNA, Viral -- analysis KW - Antiviral Agents -- therapeutic use KW - Ribavirin -- therapeutic use KW - Interferon-alpha -- therapeutic use KW - Interferon-alpha -- adverse effects KW - Hepatitis C -- virology KW - Hepatitis C -- drug therapy KW - Alanine Transaminase -- blood KW - Hepatitis C -- blood KW - Quality of Life KW - Antiviral Agents -- adverse effects KW - Ribavirin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67775667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alimentary+pharmacology+%26+therapeutics&rft.atitle=Sustained+virological+response+rates+and+health-related+quality+of+life+after+interferon+and+ribavirin+therapy+in+patients+with+chronic+hepatitis+C+virus+infection+and+persistently+normal+alanine+aminotransferase+levels.&rft.au=Bini%2C+E+J%3BMehandru%2C+S&rft.aulast=Bini&rft.aufirst=E&rft.date=2006-03-15&rft.volume=23&rft.issue=6&rft.spage=777&rft.isbn=&rft.btitle=&rft.title=Alimentary+pharmacology+%26+therapeutics&rft.issn=02692813&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-29 N1 - Date created - 2006-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Pregnancy Complications as Risk Factors for Cardiac and All-Cause Mortality T2 - 55th Annual Scientific Session of the American College of Cardiology AN - 40151608; 4156297 JF - 55th Annual Scientific Session of the American College of Cardiology AU - Biswas, Mimi S AU - Chireau, Monique AU - Honeycutt, Emily F AU - Brown, Haywood AU - Newby, L Kristin AU - Bastian, Lori A Y1 - 2006/03/11/ PY - 2006 DA - 2006 Mar 11 KW - Mortality KW - Pregnancy complications KW - Heart KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40151608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.atitle=Pregnancy+Complications+as+Risk+Factors+for+Cardiac+and+All-Cause+Mortality&rft.au=Biswas%2C+Mimi+S%3BChireau%2C+Monique%3BHoneycutt%2C+Emily+F%3BBrown%2C+Haywood%3BNewby%2C+L+Kristin%3BBastian%2C+Lori+A&rft.aulast=Biswas&rft.aufirst=Mimi&rft.date=2006-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B47BF60AC-8EA4-4311-9EB4-E9AC 186092DC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The CYBA Genotype is Associated with Altered NADPH Oxidase Activity in Patients with Cardiovascular Disease T2 - 55th Annual Scientific Session of the American College of Cardiology AN - 40093216; 4154514 JF - 55th Annual Scientific Session of the American College of Cardiology AU - Wang, Shaoshan S AU - Mehranpour, Payam AU - Li, Wei AU - Dikalov, Sergey AU - Austin, Harland AU - Zafari, A Maziar Y1 - 2006/03/11/ PY - 2006 DA - 2006 Mar 11 KW - Cardiovascular diseases KW - NADPH oxidase KW - Genotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40093216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.atitle=The+CYBA+Genotype+is+Associated+with+Altered+NADPH+Oxidase+Activity+in+Patients+with+Cardiovascular+Disease&rft.au=Wang%2C+Shaoshan+S%3BMehranpour%2C+Payam%3BLi%2C+Wei%3BDikalov%2C+Sergey%3BAustin%2C+Harland%3BZafari%2C+A+Maziar&rft.aulast=Wang&rft.aufirst=Shaoshan&rft.date=2006-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Scientific+Session+of+the+American+College+of+Cardiology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B47BF60AC-8EA4-4311-9EB4-E9AC 186092DC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Anticholinergic agents in asthma and COPD. AN - 67723907; 16488410 AB - Anticholinergic agents have important uses as bronchodilators for the treatment of obstructive airway diseases, both asthma and, more particularly, chronic obstructive pulmonary disease (COPD). Those in approved clinical use are synthetic quaternary ammonium congeners of atropine, and include ipratropium bromide, oxitropium bromide, and tiotropium bromide, each of which is very poorly absorbed when given by inhalation. Ipratropium and oxitropium have relatively short durations of action (4-8 h). They have been widely used for many years, either alone or in combination with short-acting beta-adrenergic agents such as albuterol and fenoterol, for both maintenance treatment of stable disease and for acute exacerbations of airway obstruction. Tiotropium, which was introduced in the early 2000s, has a duration of action of at least 1-2 days making it suitable for once-daily maintenance treatment of COPD. All of the above agents have a wide therapeutic margin and are safe and well tolerated by patients. JF - European journal of pharmacology AU - Gross, Nicholas J AD - Stritch-Loyola School of Medicine, Voluntary Attending Physician, Hines VA Hospital, Chicago, Hines, IL 60141, USA. Nicholas.gross@med.va.gov Y1 - 2006/03/08/ PY - 2006 DA - 2006 Mar 08 SP - 36 EP - 39 VL - 533 IS - 1-3 SN - 0014-2999, 0014-2999 KW - Bronchodilator Agents KW - 0 KW - Cholinergic Antagonists KW - Scopolamine Derivatives KW - oxitropium KW - 8G15T83E6I KW - Ipratropium KW - GR88G0I6UL KW - Tiotropium Bromide KW - XX112XZP0J KW - Index Medicus KW - Ipratropium -- adverse effects KW - Scopolamine Derivatives -- therapeutic use KW - Humans KW - Scopolamine Derivatives -- adverse effects KW - Clinical Trials as Topic KW - Ipratropium -- therapeutic use KW - Asthma -- drug therapy KW - Bronchodilator Agents -- therapeutic use KW - Cholinergic Antagonists -- therapeutic use KW - Pulmonary Disease, Chronic Obstructive -- drug therapy KW - Cholinergic Antagonists -- adverse effects KW - Bronchodilator Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67723907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Anticholinergic+agents+in+asthma+and+COPD.&rft.au=Gross%2C+Nicholas+J&rft.aulast=Gross&rft.aufirst=Nicholas&rft.date=2006-03-08&rft.volume=533&rft.issue=1-3&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-11 N1 - Date created - 2006-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A Study of the Association between Retrospective Appraisal of Childhood Reactivity and Post-Discharge Traumatic Stress in Combat Veterans AN - 877592337; 13617237 AB - A small-scale exploratory study (Ginsberg, Ayers, Burriss, & Powell, 2004) was extended to include additional participants. Results of the two studies showed a high degree of agreement and, taken together, indicate that retrospective appraisal of low magnitude adverse experiences in childhood (before age 17) may be significantly associated with post-discharge traumatic stress (PTS) in combat veterans. The number of adverse childhood experiences per individual veteran was not found to be significantly associated with PTS or other psychological outcome (state anxiety, trait anxiety, or depression). However, ratings of fear of physical effects from childhood adversity were positively and significantly correlated with PTS, and of equal significance with combat exposure in explaining PTS variance. Increased ratings of fear of childhood adversity also were significantly associated with chronicity of PTS in all participants. These results support a conclusion that retrospectively assessed childhood reactivity may represent a marker of vulnerability to chronic PTS among veterans. Further research that overcomes methodological weaknesses, explores possible mechanisms of instatement of childhood reactivity, and elaborates the relationship between reactivity and stable personality traits is needed. Practice implications manifestly include assessment and prognostication of chronic traumatic stress reactions as well as sensitivity to and incorporation of early life issues into treatment approaches. JF - Traumatology AU - Ginsberg, J P AU - Ayres, ED AU - Burriss, L B AU - Powell, DA AD - Neurobiology and PTSD Program, Shirley L. Buchanan Neuroscience Lab, Dorn VAMC, Columbia, SC, jay.ginsberg@med.va.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 61 EP - 82 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 12 IS - 1 SN - 1534-7656, 1534-7656 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877592337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traumatology&rft.atitle=A+Study+of+the+Association+between+Retrospective+Appraisal+of+Childhood+Reactivity+and+Post-Discharge+Traumatic+Stress+in+Combat+Veterans&rft.au=Ginsberg%2C+J+P%3BAyres%2C+ED%3BBurriss%2C+L+B%3BPowell%2C+DA&rft.aulast=Ginsberg&rft.aufirst=J&rft.date=2006-03-01&rft.volume=12&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Traumatology&rft.issn=15347656&rft_id=info:doi/10.1177%2F153476560601200105 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1177/153476560601200105 ER - TY - JOUR T1 - Homogeneity of the 18 QuickSIN lists. AN - 85386454; pmid-16646276 AB - The purpose of this study was to determine the list equivalency of the 18 QuickSIN (Quick Speech in Noise test) lists. Individuals with normal hearing (n = 24) and with sensorineural hearing loss (n = 72) were studied. Mean recognition performances on the 18 lists by the listeners with normal hearing were 2.8 to 4.3 dB SNR (signal-to-noise ratio), whereas the range was 10.0 to 14.3 dB SNR for the listeners with hearing loss. The psychometric functions for each list showed high performance variability across lists for listeners with hearing loss but not for listeners with normal hearing. For listeners with hearing loss, Lists 4, 5, 13, and 16 fell outside of the critical difference. The data from this study suggest nine lists that provide homogenous results for listeners with and without hearing loss. Finally, there was an 8.7 dB difference in performances between the two groups indicating a more favorable signal-to-noise ratio required by the listeners with hearing loss to obtain equal performance. JF - Journal of the American Academy of Audiology AU - McArdle, Rachel A AU - Wilson, Richard H AD - The Bay Pines VA Healthcare System, Bay Pines, Florida 33744, USA. Rachel.mcardle@med.va.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 157 EP - 167 VL - 17 IS - 3 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Acoustic Stimulation KW - Adult KW - Age Factors KW - Aged KW - *Audiometry, Speech: methods KW - Female KW - *Hearing Loss, High-Frequency: diagnosis KW - *Hearing Loss, Sensorineural: diagnosis KW - Humans KW - Male KW - *Noise: adverse effects KW - Sensitivity and Specificity KW - *Speech Perception: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85386454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Organization+of+the+membrane+domain+of+the+human+liver+sodium%2Fbile+acid+cotransporter.&rft.au=Hall%C3%A9n%2C+S%3BMareninova%2C+O%3BBr%C3%A4nd%C3%A9n%2C+M%3BSachs%2C+G&rft.aulast=Hall%C3%A9n&rft.aufirst=S&rft.date=2002-06-11&rft.volume=41&rft.issue=23&rft.spage=7253&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: J Am Acad Audiol. 2006 Sep;17(8):617-8[16999256] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Practical and theoretical considerations in designing rehabilitation trials: the DVBIC cognitive-didactic versus functional-experiential treatment study experience. AN - 85385468; pmid-16569991 AB - This is a descriptive article outlining issues in the development and implementation of a multisite randomized rehabilitation trial for brain injury treatment. The goal of this article is to present practical and theoretical considerations in designing and conducting multicenter rehabilitation trials. Practical issues discussed include (a) treatment setting, (b) patient accessibility in determining the research question of interest, as well as inclusion and exclusion criteria, (c) research protocol development in the context of rehabilitation standard of care, and (d) protocol treatments in the context of realistic cost-benefits analysis. Rehabilitation theory is discussed as playing an important role designing the specifics of the protocol interventions. The Defense and Veterans Brain Injury Center Veterans Health Administration cognitive-didactic versus functional-experiential study methodology is used for illustrative purposes. This study evaluated 2 alternative approaches to treatment: one focusing on underlying cognitive processes and the second on errorless learning in everyday functional situations. Lessons learned over the course of completing the treatment trial are discussed. JF - The Journal of head trauma rehabilitation AU - Vanderploeg, Rodney D AU - Collins, Rose C AU - Sigford, Barbara AU - Date, Elaine AU - Schwab, Karen AU - Warden, Deborah AD - James A. Haley Veterans Affairs Medical Center, FL 33612, USA. rodney.vanderploeg@va.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 179 EP - 193 VL - 21 IS - 2 SN - 0885-9701, 0885-9701 KW - Index Medicus KW - National Library of Medicine KW - *Brain Injuries: rehabilitation KW - Clinical Protocols KW - *Cognitive Therapy KW - Humans KW - Patient Selection KW - *Randomized Controlled Trials as Topic: methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85385468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+head+trauma+rehabilitation&rft.atitle=Practical+and+theoretical+considerations+in+designing+rehabilitation+trials%3A+the+DVBIC+cognitive-didactic+versus+functional-experiential+treatment+study+experience.&rft.au=Vanderploeg%2C+Rodney+D%3BCollins%2C+Rose+C%3BSigford%2C+Barbara%3BDate%2C+Elaine%3BSchwab%2C+Karen%3BWarden%2C+Deborah&rft.aulast=Vanderploeg&rft.aufirst=Rodney&rft.date=2006-03-01&rft.volume=21&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+head+trauma+rehabilitation&rft.issn=08859701&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Sleep quality and the role of sleep medications for veterans with chronic pain. AN - 67900954; 16634723 AB - The purpose of this study was to investigate the nature of sleep problems in veterans presenting to a pain clinic, factors that predict likelihood of being prescribed a sleep medication, types of medications prescribed, and the relationships between sleep medication use and sleep quality, pain, and depression. Participants were 201 consecutive patients referred to a Veterans Affairs outpatient pain clinic. They were administered the Pittsburgh Sleep Quality Index, Multidimensional Pain Inventory, and Beck Depression Inventory at intake and 2-month follow-up. Sleep and opioid medication prescriptions were also monitored. Pain severity did not predict global sleep quality; global sleep quality was not predictive of pain severity. Greater depression predicted both more severe pain and more sleep impairment. Having previously been prescribed such medications was the only significant predictor of being prescribed a sleep medication at the time of the 2-month assessment. For the 45% of participants on sleep medications, these medications were not associated with any significant change in pain factors or depression. However, sleep medication use was associated with worse global sleep quality, sleep duration, and sleep efficiency. Opioid prescription was not a significant predictor of sleep factors, pain-related variables, or depression symptoms. Results suggest depression may contribute more significantly to sleep problems than pain-related variables in this population. The data suggest the need for controlled, prospective studies of sleep medication to further investigate the impact of sleep medications on sleep components in patients with chronic pain. JF - Pain medicine (Malden, Mass.) AU - Chapman, Judith B AU - Lehman, Cassandra L AU - Elliott, Janette AU - Clark, J David AD - Psychology Service--116B, Department of Veterans Affairs, Palo Alto Health Care System, 3801 Miranda Avenue, California 94304, USA. judith.chapman@med.va.gov PY - 2006 SP - 105 EP - 114 VL - 7 IS - 2 SN - 1526-2375, 1526-2375 KW - Hypnotics and Sedatives KW - 0 KW - Narcotics KW - Index Medicus KW - Sleep -- physiology KW - Humans KW - Aged KW - Narcotics -- adverse effects KW - Pain Measurement KW - Predictive Value of Tests KW - Sleep -- drug effects KW - Aged, 80 and over KW - Adult KW - Pain Threshold -- drug effects KW - Treatment Outcome KW - Surveys and Questionnaires KW - Chronic Disease -- drug therapy KW - Middle Aged KW - Pain Threshold -- physiology KW - Neuropsychological Tests KW - Female KW - Male KW - Pain, Intractable -- psychology KW - Hypnotics and Sedatives -- therapeutic use KW - Veterans -- statistics & numerical data KW - Sleep Wake Disorders -- drug therapy KW - Depressive Disorder -- psychology KW - Depressive Disorder -- etiology KW - Veterans -- psychology KW - Sleep Wake Disorders -- psychology KW - Sleep Wake Disorders -- etiology KW - Pain, Intractable -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67900954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain+medicine+%28Malden%2C+Mass.%29&rft.atitle=Sleep+quality+and+the+role+of+sleep+medications+for+veterans+with+chronic+pain.&rft.au=Chapman%2C+Judith+B%3BLehman%2C+Cassandra+L%3BElliott%2C+Janette%3BClark%2C+J+David&rft.aulast=Chapman&rft.aufirst=Judith&rft.date=2006-03-01&rft.volume=7&rft.issue=2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Pain+medicine+%28Malden%2C+Mass.%29&rft.issn=15262375&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-09 N1 - Date created - 2006-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Geriatric alcoholism: pathophysiology and dental implications. AN - 67807652; 16570466 AB - The authors reviewed the clinical features, epidemiology, diagnosis, medical treatment, orofacial findings and dental treatment of geriatric patients with alcoholism. The authors conducted MEDLINE searches for the period 1995 through 2004 using the terms "alcoholism," "geriatric," "pathophysiology," "treatment" and "dentistry." They selected reports published in English in peer-reviewed journals for further review. Physiological changes associated with aging permit the harmful effects of drinking alcohol to arise at lower levels of consumption than in younger people. Excessive use of alcohol exacerbates the medical and emotional problems associated with aging and predisposes the person to adverse drug reactions with medications controlling these illnesses. The incidence of dental disease in this population is extensive because of diminished salivary flow and a disinterest in performing appropriate oral hygiene techniques. Concurrent abuse of tobacco products worsens dental disease and heightens the risk of developing oral cancer. Identification of patients who abuse alcohol, a cancer-screening examination, preventive dental education, and use of saliva substitutes and anticaries agents are indicated. Clinicians must take precautions when performing surgery and when prescribing or administering analgesics, antibiotics or sedative agents that are likely to have an adverse interaction with alcohol. JF - Journal of the American Dental Association (1939) AU - Friedlander, Arthur H AU - Norman, Dean C AD - VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, Calif. 90073, USA. friedlander@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 330 EP - 338 VL - 137 IS - 3 SN - 0002-8177, 0002-8177 KW - Dentistry KW - Index Medicus KW - Age Factors KW - Humans KW - Aging KW - Aged KW - Alcoholism -- epidemiology KW - Alcoholic Beverages -- adverse effects KW - Dental Care for Aged -- methods KW - Alcoholism -- physiopathology KW - Mouth Diseases -- etiology KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67807652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Geriatric+alcoholism%3A+pathophysiology+and+dental+implications.&rft.au=Friedlander%2C+Arthur+H%3BNorman%2C+Dean+C&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2006-03-01&rft.volume=137&rft.issue=3&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-16 N1 - Date created - 2006-03-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Opioid substitution treatment reduces substance use equivalently in patients with and without posttraumatic stress disorder. AN - 67783021; 16562404 AB - The purpose of this study was to determine whether opioid-dependent patients with diagnosed posttraumatic stress disorder (PTSD) have poorer long-term outcomes in opioid substitution treatment than do patients without PTSD. This prospective observational study examined outcomes of 255 opioid-dependent patients (men = 248) entering opioid substitution treatment at eight clinics in the Veterans Health Administration (VHA). Subjects were interviewed at treatment entry, 6 months, and 1 year about substance use and related problems, health status, treatment satisfaction, and non-VHA health care utilization. Medical records were reviewed to obtain toxicology results, health care utilization data, and diagnoses. Medical record review identified a diagnosis of PTSD in 71 (28%) patients. Substance-use and mental-health outcomes and health care utilization in the first year following treatment entry were compared between patients with and without a diagnosis of PTSD. Patients with and without PTSD had similar treatment responses. Although patients with PTSD had longer histories of drug use at intake, at 1-year follow-up they showed reductions in heroin, cocaine, and alcohol use, comparable to patients without the disorder. PTSD patients received higher doses of opiate medication, attended more psychosocial treatment sessions for substance-use disorder, and had better treatment retention. Psychiatric symptoms for patients with PTSD were more severe at intake and showed little improvement throughout treatment. Opioid substitution therapy is as effective at reducing substance use in PTSD patients as it is in patients without the disorder, but additional services are needed for treatment of psychological problems that are largely unchanged by treatment for addiction. JF - Journal of studies on alcohol AU - Trafton, Jodie A AU - Minkel, Jared AU - Humphreys, Keith AD - Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System, California, USA. Jodie.Trafton@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 228 EP - 235 VL - 67 IS - 2 SN - 0096-882X, 0096-882X KW - Narcotics KW - 0 KW - Street Drugs KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Alcoholism -- rehabilitation KW - Humans KW - Cocaine-Related Disorders -- psychology KW - Prognosis KW - Aged KW - Cocaine-Related Disorders -- epidemiology KW - Alcoholism -- psychology KW - Comorbidity KW - Health Status Indicators KW - Alcoholism -- epidemiology KW - Heroin Dependence -- epidemiology KW - Substance Abuse Detection KW - Risk Factors KW - Marijuana Abuse -- rehabilitation KW - Adult KW - Treatment Outcome KW - Heroin Dependence -- rehabilitation KW - Middle Aged KW - Marijuana Abuse -- psychology KW - Marijuana Abuse -- epidemiology KW - Follow-Up Studies KW - Heroin Dependence -- psychology KW - Male KW - Female KW - Opioid-Related Disorders -- epidemiology KW - Combat Disorders -- psychology KW - Opioid-Related Disorders -- psychology KW - Veterans -- psychology KW - Opioid-Related Disorders -- rehabilitation KW - Narcotics -- administration & dosage KW - Combat Disorders -- rehabilitation KW - Methadone -- administration & dosage KW - Combat Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67783021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.atitle=Lexical+and+talker+effects+on+word+recognition+among+native+and+non-native+listeners+with+normal+and+impaired+hearing.&rft.au=Takayanagi%2C+Sumiko%3BDirks%2C+Donald+D%3BMoshfegh%2C+Anahita&rft.aulast=Takayanagi&rft.aufirst=Sumiko&rft.date=2002-06-01&rft.volume=45&rft.issue=3&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.issn=10924388&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-08 N1 - Date created - 2006-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The cost-effectiveness of strategies to reduce mortality from an intentional release of aerosolized anthrax spores. AN - 67733999; 16525172 AB - Intentional exposures to aerosolized Bacillus anthracis spores have caused fatalities. To evaluate the cost-effectiveness of strategies to reduce mortality from future inhalational anthrax exposures. Computer cohort simulation of a 100,000-person single-site exposure (worst-case scenario) and a 100-person multiple-site exposure (resembling the recent US attack). For each scenario, universal vaccination and an emergency surveillance and response (ESR) system were compared with a default strategy that assumed eventual discovery of the exposure. If an exposure was unlikely to occur or was small in scale, neither vaccination nor an ESR system was cost-effective. If an exposure was certain and large in scale, an ESR system was more cost-effective than vaccination ($73 v. $29,600 per life-year saved), and a rapid response saved more lives than improved surveillance. Strategies to reduce deaths from anthrax attacks are cost-effective only if large exposures are certain. A faster response is more beneficial than enhanced surveillance. JF - Medical decision making : an international journal of the Society for Medical Decision Making AU - Braithwaite, R Scott AU - Fridsma, Douglas AU - Roberts, Mark S AD - Section of General Internal Medicine, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA. ronald.braithwaite@med.va.gov PY - 2006 SP - 182 EP - 193 VL - 26 IS - 2 SN - 0272-989X, 0272-989X KW - Aerosol Propellants KW - 0 KW - Index Medicus KW - Computer Simulation KW - Inhalation Exposure KW - Humans KW - Emergency Medical Services -- economics KW - Cost-Benefit Analysis KW - Bacillus anthracis -- pathogenicity KW - Vaccination KW - United States -- epidemiology KW - Population Surveillance KW - Bioterrorism -- economics KW - Anthrax -- prevention & control KW - Anthrax -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67733999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+decision+making+%3A+an+international+journal+of+the+Society+for+Medical+Decision+Making&rft.atitle=The+cost-effectiveness+of+strategies+to+reduce+mortality+from+an+intentional+release+of+aerosolized+anthrax+spores.&rft.au=Braithwaite%2C+R+Scott%3BFridsma%2C+Douglas%3BRoberts%2C+Mark+S&rft.aulast=Braithwaite&rft.aufirst=R&rft.date=2006-03-01&rft.volume=26&rft.issue=2&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Medical+decision+making+%3A+an+international+journal+of+the+Society+for+Medical+Decision+Making&rft.issn=0272989X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-16 N1 - Date created - 2006-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Management of hepatitis C disease among VA patients with schizophrenia and substance use disorders. AN - 67729954; 16525001 AB - Rates of hepatitis C (HCV) infection, testing, and treatment were compared among patients with schizophrenia, a substance use disorder, or co-occurring schizophrenia or schizoaffective disorder and a substance use disorder and a control group. Information about 293,445 patients of the Northwest Veterans Healthcare Administration was obtained. The substance use disorder group constituted 13.6 percent of the sample; the schizophrenia group, 1.6 percent; and the co-occurring-disorders group, 1.4 percent. Respectively, these groups were approximately four, two, and six times as likely as the control group to receive HCV testing and about seven, two, and eight times as likely to be infected. The rate of interferon (IFN) therapy was significantly lower for the substance use group and the group with co-occurring disorders. However, the magnitude of the differences was not substantial, suggesting that these high-risk groups were not excluded from IFN therapy. JF - Psychiatric services (Washington, D.C.) AU - Huckans, Marilyn S AU - Blackwell, Aaron D AU - Harms, Todd A AU - Hauser, Peter AD - Northwest Hepatitis C Resource Center, Portland Veterans Affairs Medical Center, and Department of Psychiatry at Oregon Health and Science University 97239, USA. marilyn.huckans@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 403 EP - 406 VL - 57 IS - 3 SN - 1075-2730, 1075-2730 KW - Interferons KW - 9008-11-1 KW - Index Medicus KW - United States KW - Oregon KW - United States Department of Veterans Affairs KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Schizophrenic Psychology KW - Psychotic Disorders -- diagnosis KW - Veterans KW - Hepatitis C -- drug therapy KW - Hepatitis C -- diagnosis KW - Substance-Related Disorders -- drug therapy KW - Schizophrenia -- diagnosis KW - Schizophrenia -- drug therapy KW - Substance-Related Disorders -- psychology KW - Interferons -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67729954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Management+of+hepatitis+C+disease+among+VA+patients+with+schizophrenia+and+substance+use+disorders.&rft.au=Huckans%2C+Marilyn+S%3BBlackwell%2C+Aaron+D%3BHarms%2C+Todd+A%3BHauser%2C+Peter&rft.aulast=Huckans&rft.aufirst=Marilyn&rft.date=2006-03-01&rft.volume=57&rft.issue=3&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sodium oxybate for cataplexy. AN - 67729651; 16507620 AB - To review the pharmacology, pharmacokinetics, clinical efficacy, adverse effects, drug interactions, precautions, dosing recommendations, and patient counseling of sodium oxybate for the treatment of cataplexy in patients with narcolepsy. OVID and PubMed databases were searched (1966-January 2006) using the key words sodium oxybate, gamma-hydroxybutyrate, narcolepsy, and cataplexy. Only English-language articles were selected. All information on sodium oxybate related to narcolepsy and cataplexy was considered. Study selection included human trials evaluating safety and efficacy of sodium oxybate for the treatment of cataplexy. Sodium oxybate is approved by the Food and Drug Administration for the treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy. In placebo-controlled trials, sodium oxybate demonstrated efficacy in reducing the number of cataplexy attacks. The dosing regimen includes a split dose given at bedtime and 2.5-4 hours later due to its short elimination half-life. The drug is generally well tolerated, with headache, nausea, dizziness, pain, and somnolence being the most common adverse events. Sodium oxybate is safe and effective for the treatment of cataplexy. Potential disadvantages include a multiple dosing regimen, abuse potential, cost, and a closed distribution system. Potential advantages demonstrated in clinical trials include significant decreases in the number of weekly cataplexy attacks, improvement in daytime sleepiness, and improvement in the Clinical Global Impression of Change score and nighttime awakenings. Overall, sodium oxybate provides a new option for the treatment of cataplexy. JF - The Annals of pharmacotherapy AU - Lemon, Michael D AU - Strain, Joe D AU - Farver, Debra K AD - College of Pharmacy, South Dakota State University; Veterans Affairs Black Hills Health Care System, Fort Meade, 57741, USA. Michael.lemon@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 433 EP - 40; quiz 581-2 VL - 40 IS - 3 SN - 1060-0280, 1060-0280 KW - Sodium Oxybate KW - 7G33012534 KW - Index Medicus KW - Sleep -- drug effects KW - Humans KW - Databases, Factual KW - Clinical Trials as Topic KW - Narcolepsy -- complications KW - Cataplexy -- drug therapy KW - Sodium Oxybate -- therapeutic use KW - Cataplexy -- complications KW - Sodium Oxybate -- pharmacokinetics KW - Sodium Oxybate -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67729651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Sodium+oxybate+for+cataplexy.&rft.au=Lemon%2C+Michael+D%3BStrain%2C+Joe+D%3BFarver%2C+Debra+K&rft.aulast=Lemon&rft.aufirst=Michael&rft.date=2006-03-01&rft.volume=40&rft.issue=3&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-26 N1 - Date created - 2006-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quetiapine for insomnia associated with refractory depression exacerbated by phenelzine. AN - 67729149; 16478812 AB - To report the successful treatment of phenelzine-associated insomnia with low-dose quetiapine in a patient with refractory depression. A 42-year-old white man with severe major depression unresponsive to selective serotonin-reuptake inhibitors, bupropion, and tricyclic antidepressants improved following treatment with the monoamine oxidase inhibitor (MAOI) phenelzine. Insomnia, present to a moderate degree prior to antidepressant therapy, worsened markedly following phenelzine treatment and failed to respond to diphenhydramine, temazepam, triazolam, clonazepam, zolpidem, or trazodone given at high therapeutic doses. Sleep disturbance resolved with low-dose (50 mg) adjunctive quetiapine, with no adverse effects. Major depression refractory to standard therapy is a common and serious condition. Some cases respond to MAOIs; however, orthostatic hypotension and insomnia frequently occur. Potentially serious MAOI interactions with psychotropic drugs have raised concerns about combining these agents. In this case, a failure of a number of other medications known to treat MAOI-associated insomnia safely prompted a trial of quetiapine. Despite the possibility that enhanced serotonergic activity might have resulted in serotonin syndrome, no adverse interactions between phenelzine and quetiapine were noted. The use of low-dose, once-daily quetiapine, along with its unique binding properties, may account for its increased safety in combination with phenelzine. This case illustrates that low-dose quetiapine may be an alternative treatment for phenelzine-associated insomnia. Further case reports are needed to establish the safety and effectiveness of combining these agents. JF - The Annals of pharmacotherapy AU - Sokolski, Kenneth N AU - Brown, Brenda J AD - Mood Disorders Clinic, Veterans Affairs Long Beach Healthcare System, Long Beach, CA 90822, USA. kenneth.sokolski@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 567 EP - 570 VL - 40 IS - 3 SN - 1060-0280, 1060-0280 KW - Antipsychotic Agents KW - 0 KW - Dibenzothiazepines KW - Monoamine Oxidase Inhibitors KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Phenelzine KW - O408N561GF KW - Index Medicus KW - Humans KW - Adult KW - Male KW - Phenelzine -- adverse effects KW - Monoamine Oxidase Inhibitors -- adverse effects KW - Sleep Initiation and Maintenance Disorders -- drug therapy KW - Depressive Disorder, Major -- complications KW - Antipsychotic Agents -- therapeutic use KW - Sleep Initiation and Maintenance Disorders -- chemically induced KW - Dibenzothiazepines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67729149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Quetiapine+for+insomnia+associated+with+refractory+depression+exacerbated+by+phenelzine.&rft.au=Sokolski%2C+Kenneth+N%3BBrown%2C+Brenda+J&rft.aulast=Sokolski&rft.aufirst=Kenneth&rft.date=2006-03-01&rft.volume=40&rft.issue=3&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-26 N1 - Date created - 2006-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pretreatment and during treatment risk factors for dropout among patients with substance use disorders. AN - 67698685; 15979244 AB - The aim of this study was to use pretreatment and treatment factors to predict dropout from residential substance use disorder program and to examine how the treatment environment modifies the risk for dropout. This study assessed 3649 male patients at entry to residential substance use disorder treatment and obtained information about their perceptions of the treatment environment. Baseline factors that predicted dropout included younger age, greater cognitive dysfunction, more drug use, and lower severity of alcohol dependence. Patients in treatment environments appraised as low in support or high in control also were more likely to drop out. Further, patients at high risk of dropout were especially likely to dropout when treated in a highly controlling treatment environment. Better screening of risk factors for dropout and efforts to create a less controlling treatment environment may result in increased retention in substance use disorder treatment. JF - Addictive behaviors AU - McKellar, John AU - Kelly, John AU - Harris, Alex AU - Moos, Rudolf AD - Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System and Stanford University School of Medicine, (152), 795 Willow Road, Menlo Park, CA 94025, USA. John.McKellar@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 450 EP - 460 VL - 31 IS - 3 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Patient Satisfaction KW - Logistic Models KW - Risk Factors KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Predictive Value of Tests KW - Middle Aged KW - Male KW - Social Environment KW - Patient Dropouts -- statistics & numerical data KW - Patient Dropouts -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67698685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Pretreatment+and+during+treatment+risk+factors+for+dropout+among+patients+with+substance+use+disorders.&rft.au=McKellar%2C+John%3BKelly%2C+John%3BHarris%2C+Alex%3BMoos%2C+Rudolf&rft.aulast=McKellar&rft.aufirst=John&rft.date=2006-03-01&rft.volume=31&rft.issue=3&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-13 N1 - Date created - 2006-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gatifloxacin interference with opiate urine drug screen. AN - 67697521; 16503726 AB - A 48-year-old man participating in a residential treatment program was treated with gatifloxacin for a urinary tract infection. While taking the antibiotic, two urine screens were positive for opiates; results of previous urine opiate screens had been negative. Confirmatory tests using a different assay method, however, gave negative results for opiates. Two weeks after completing gatifloxacin therapy, the patient's urine screen was negative for opiates. Application of the Naranjo adverse drug reaction probability scale indicated that gatifloxacin probably was associated with this patient's positive urine opiate screen. Fluoroquinolones as a class are among several compounds that have demonstrated a propensity to cross-react with enzyme immunoassay urine drug screens for opiates. Occurrence of cross-reactivity appears to vary among individual assays. The mechanism by which fluoroquinolones cross-react with the immunoassay is unknown. Falsepositive results could have negative effects on patient care, and ramifications of a positive drug screen include possible dismissal from a substance abuse treatment program. Confirmatory analysis using a different assay method is therefore necessary to verify the presence of the target drug. JF - Pharmacotherapy AU - Straley, Craig M AU - Cecil, Eric J AU - Herriman, Mark P AD - Department of Pharmacy Practice, College of Pharmacy, Ferris State University, Big Rapids, Michigan, USA. craig.straley@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 435 EP - 439 VL - 26 IS - 3 SN - 0277-0008, 0277-0008 KW - Anti-Bacterial Agents KW - 0 KW - Fluoroquinolones KW - Narcotics KW - gatifloxacin KW - L4618BD7KJ KW - Index Medicus KW - Urinary Tract Infections -- drug therapy KW - Anti-Bacterial Agents -- therapeutic use KW - Humans KW - Gas Chromatography-Mass Spectrometry KW - Opioid-Related Disorders -- rehabilitation KW - Opioid-Related Disorders -- urine KW - Male KW - Immunoassay KW - False Positive Reactions KW - Fluoroquinolones -- therapeutic use KW - Narcotics -- urine KW - Substance Abuse Detection -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67697521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Gatifloxacin+interference+with+opiate+urine+drug+screen.&rft.au=Straley%2C+Craig+M%3BCecil%2C+Eric+J%3BHerriman%2C+Mark+P&rft.aulast=Straley&rft.aufirst=Craig&rft.date=2006-03-01&rft.volume=26&rft.issue=3&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-01 N1 - Date created - 2006-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential effects of alcohol consumption and withdrawal on circadian temperature and activity rhythms in Sprague-Dawley, Lewis, and Fischer male and female rats. AN - 67689012; 16499484 AB - Hypothalamic synthesis and secretion of corticotropin-releasing hormone (CRH), a putative mediator of various behavioral and physiological responses to ethanol (EtOH), is defective in inbred Lewis (LEW) rats in comparison with their genetically related inbred Fischer 344 (F344) and outbred Sprague-Dawley (S-D) strains. We aimed to characterize the effects of continuous EtOH consumption and withdrawal on circadian patterns of body temperature and spontaneous locomotor activity in males and females of these 3 strains. Adult LEW, F344, and S-D males and randomly cycling females were fed an EtOH-containing liquid diet or the control (pair-fed or lab chow and water) diet for 14 days. Biotelemetric body temperature data for the last 3 days of EtOH diet feeding and the first 3 days of withdrawal were subjected to cosinor analysis of the circadian rhythm parameters of midline-estimating statistic of rhythm (MESOR), amplitude, and acrophase. Mean dark-phase activity during these periods was also computed. In the control diet condition, the MESORs and amplitudes of LEW males were lower than those of F344 males. MESORs of rhythms of LEW females were lower than those of both F344 and S-D females. Ethanol consumption caused hypothermia with reduced MESORs and amplitudes of LEW and F344 males and amplitudes of F344 and S-D females. Upon withdrawal, MESORs of the males increased during each day as the amplitudes decreased, reflective of their initial withdrawal-induced dark-phase hypothermia, which was most pronounced in the LEW males, followed by light-phase hyperthermia. MESORs of females were not affected by withdrawal; their amplitudes were differentially affected. Acrophase of LEW males shifted from dark to light on the first day of withdrawal. All rats responded to EtOH exposure with a reduction of dark-phase spontaneous locomotor activity and an immediate increase upon withdrawal. Body temperature rhythms of the males were generally more affected by EtOH consumption and withdrawal than the females; within each sex, LEW and F344 rats differed significantly. The specific hormonal factors that mediate the differential temperature responses remain to be defined. JF - Alcoholism, clinical and experimental research AU - Taylor, Anna N AU - Tio, Delia L AU - Bando, Jennifer K AU - Romeo, Horacio E AU - Prolo, Paolo AD - Veterans Administration Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, California, USA. ataylor@mednet.ucla.edu Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 438 EP - 447 VL - 30 IS - 3 SN - 0145-6008, 0145-6008 KW - Central Nervous System Depressants KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Rats, Inbred Lew KW - Rats, Inbred F344 KW - Sex Characteristics KW - Telemetry KW - Body Weight -- drug effects KW - Motor Activity -- drug effects KW - Species Specificity KW - Male KW - Female KW - Ethanol -- adverse effects KW - Central Nervous System Depressants -- pharmacology KW - Substance Withdrawal Syndrome -- physiopathology KW - Central Nervous System Depressants -- adverse effects KW - Body Temperature -- drug effects KW - Ethanol -- pharmacology KW - Circadian Rhythm -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67689012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Differential+effects+of+alcohol+consumption+and+withdrawal+on+circadian+temperature+and+activity+rhythms+in+Sprague-Dawley%2C+Lewis%2C+and+Fischer+male+and+female+rats.&rft.au=Taylor%2C+Anna+N%3BTio%2C+Delia+L%3BBando%2C+Jennifer+K%3BRomeo%2C+Horacio+E%3BProlo%2C+Paolo&rft.aulast=Taylor&rft.aufirst=Anna&rft.date=2006-03-01&rft.volume=30&rft.issue=3&rft.spage=438&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-12 N1 - Date created - 2006-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Brain metabolite concentrations and neurocognition during short-term recovery from alcohol dependence: Preliminary evidence of the effects of concurrent chronic cigarette smoking. AN - 67688390; 16499496 AB - Longitudinal studies of brain tissue metabolite recovery in short-term abstinent alcoholics have primarily investigated the frontal lobes and cerebellum with variable results. Preliminary proton magnetic resonance spectroscopic imaging (1H MRSI) suggested that chronic cigarette smoking exacerbates alcohol-induced brain injury in 1-week abstinent alcoholics. However, the potential effects of chronic cigarette smoking on the recovery of alcohol-induced brain injury have not been studied. Multislice short-echo time 1H MRSI was used to measure longitudinal changes in common brain metabolites in 25 recovering alcohol-dependent individuals (RA), retrospectively assigned to smoking (n = 14) and nonsmoking (n = 11) subgroups. Recovering alcohol-dependent individuals in longitudinal analyses were studied after approximately 7 and 34 days of abstinence from alcohol. In cross-sectional analyses, 36 RA (19 smokers, 17 nonsmokers) with approximately 34 days of sobriety were compared with 29 light drinkers (LD). Relationships between neurocognition and metabolite concentrations in abstinent RA were also examined. Over 1 month of abstinence from alcohol, RA, as a group, showed significant increases of regional N-acetylaspartate (NAA; marker of neuronal viability) and choline-containing compounds (Cho; marker of cell membrane synthesis/turnover) primarily in frontal and parietal lobes. These increases appeared to be driven by nonsmoking RA. Cross-sectional results indicate that metabolite levels in RA at 35 days of sobriety are not significantly different from those in LD in most regions, except for lower NAA and Cho in parietal WM and subcortical structures. However, metabolite levels at that time appear to be strongly modulated by smoking status. The patterns of metabolite-neurocognition relationships were different for nonsmoking and smoking RA. Within the first weeks of sobriety, regional brain NAA and Cho levels increased, but metabolite levels did not normalize in all brain regions after 35 days of sobriety. Neurobiologic recovery in RA appeared to be adversely affected by chronic smoking. Greater consideration of the effects of continued cigarette smoking on the neurobiologic and neurocognitive recovery of alcohol-dependent individuals is warranted. JF - Alcoholism, clinical and experimental research AU - Durazzo, Timothy C AU - Gazdzinski, Stefan AU - Rothlind, Johannes C AU - Banys, Peter AU - Meyerhoff, Dieter J AD - San Francisco Veterans Administration Medical Center, San Francisco, California 94121, USA. timothy.durazzo@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 539 EP - 551 VL - 30 IS - 3 SN - 0145-6008, 0145-6008 KW - Aspartic Acid KW - 30KYC7MIAI KW - N-acetylaspartate KW - 997-55-7 KW - Choline KW - N91BDP6H0X KW - Index Medicus KW - Magnetic Resonance Imaging KW - Aspartic Acid -- metabolism KW - Cerebral Cortex -- metabolism KW - Memory -- drug effects KW - Humans KW - Choline -- metabolism KW - Learning -- drug effects KW - Erythrocytes -- metabolism KW - Longitudinal Studies KW - Cross-Sectional Studies KW - Thalamus -- metabolism KW - Psychiatric Status Rating Scales KW - Aspartic Acid -- analogs & derivatives KW - Psychomotor Performance -- drug effects KW - Adult KW - Data Interpretation, Statistical KW - Middle Aged KW - Image Processing, Computer-Assisted KW - Male KW - Female KW - Intelligence Tests KW - Cognition -- drug effects KW - Brain Chemistry -- drug effects KW - Smoking -- metabolism KW - Alcoholism -- metabolism KW - Smoking -- psychology KW - Alcoholism -- psychology KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67688390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Brain+metabolite+concentrations+and+neurocognition+during+short-term+recovery+from+alcohol+dependence%3A+Preliminary+evidence+of+the+effects+of+concurrent+chronic+cigarette+smoking.&rft.au=Durazzo%2C+Timothy+C%3BGazdzinski%2C+Stefan%3BRothlind%2C+Johannes+C%3BBanys%2C+Peter%3BMeyerhoff%2C+Dieter+J&rft.aulast=Durazzo&rft.aufirst=Timothy&rft.date=2006-03-01&rft.volume=30&rft.issue=3&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-12 N1 - Date created - 2006-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cell phones for ecological momentary assessment with cocaine-addicted homeless patients in treatment. AN - 67682102; 16490673 AB - This is the first study to examine whether cell phones could be used to collect ecological momentary assessment (EMA) data with homeless crack cocaine-addicted adults in treatment. The study adapted an EMA method to examine behavior in real time using cell phones and computer-automated telephone interviewing. Participants treated in an intensive outpatient treatment program were given cell phones for a 2-week period to record current states of cocaine craving and using episodes. Results showed cell phone technology could reliably deliver a computerized survey; this homeless population would use a cell phone to report craving and using episodes, and drug use reported via EMA was in agreement with urine toxicology results for 73% of participants. Of 30 participants, 24 (80%) completed the full 2-week protocol. Participants indicated the survey made them more aware of phenomena leading to cravings and use, suggesting the usefulness of EMA as a potential intervention. JF - Journal of substance abuse treatment AU - Freedman, Michelle J AU - Lester, Kristin M AU - McNamara, Cecelia AU - Milby, Jesse B AU - Schumacher, Joseph E AD - Department of Psychology, University of Alabama at Birmingham, 35294, USA. michelle.freedman@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 105 EP - 111 VL - 30 IS - 2 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Disruptive, Impulse Control, and Conduct Disorders -- epidemiology KW - Community Mental Health Services -- supply & distribution KW - Humans KW - Adult KW - Time Factors KW - Male KW - Female KW - Ambulatory Care KW - Environment KW - Homeless Persons -- statistics & numerical data KW - Surveys and Questionnaires KW - Cocaine-Related Disorders -- epidemiology KW - Cell Phones KW - Cocaine-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67682102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Cell+phones+for+ecological+momentary+assessment+with+cocaine-addicted+homeless+patients+in+treatment.&rft.au=Freedman%2C+Michelle+J%3BLester%2C+Kristin+M%3BMcNamara%2C+Cecelia%3BMilby%2C+Jesse+B%3BSchumacher%2C+Joseph+E&rft.aulast=Freedman&rft.aufirst=Michelle&rft.date=2006-03-01&rft.volume=30&rft.issue=2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2006-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of rosiglitazone on lipids, adipokines, and inflammatory markers in nondiabetic patients with low high-density lipoprotein cholesterol and metabolic syndrome. AN - 67664200; 16357312 AB - PPAR-gamma agonists improve insulin sensitivity and glycemic control in type 2 diabetes and may reduce atherosclerosis progression. Thus, PPAR-gamma agonists may be an effective therapy for metabolic syndrome. However, the full spectrum of potentially antiatherogenic mechanisms of PPAR-gamma agonists have not been fully tested in nondiabetic patients with metabolic syndrome. We performed a prospective, double-blinded, placebo-controlled study of 60 nondiabetic subjects with low high-density lipoprotein cholesterol (HDL-C) level and metabolic syndrome to rosiglitazone 8 mg daily or placebo for 12 weeks. We found no significant effect of rosiglitazone on HDL-C (+5.5% versus +5.8%, P=0.89), and an increase in total cholesterol (+8% versus -1%; P=0.03). Nevertheless, rosiglitazone significantly increased adiponectin (+168% versus +25%; P<0.001), and lowered resistin (-6% versus +4%; P=0.009), C-reactive protein (-32% versus +36%, P=0.002), interleukin (IL)-6 (-22% versus +4%, P<0.001), and soluble tumor-necrosis factor-alpha receptor-2 (-5% versus +7%, P<0.001). These findings suggest that rosiglitazone, presumably through its PPAR-gamma agonist properties, has direct effects on inflammatory markers and adipokines in the absence of favorable lipid effects. These findings may help explain the mechanism underlying the possible antiatherosclerotic effects of rosiglitazone. JF - Arteriosclerosis, thrombosis, and vascular biology AU - Samaha, Frederick F AU - Szapary, Philippe O AU - Iqbal, Nayyar AU - Williams, Monica M AU - Bloedon, LeAnne T AU - Kochar, Arshneel AU - Wolfe, Megan L AU - Rader, Daniel J AD - Cardiovascular Division, Department of Medicine, Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA, USA. rick.samaha@med.va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 624 EP - 630 VL - 26 IS - 3 KW - Adiponectin KW - 0 KW - Apolipoproteins B KW - Biomarkers KW - Cholesterol, HDL KW - Fatty Acids, Nonesterified KW - Hypoglycemic Agents KW - Interleukin-6 KW - PPAR gamma KW - RETN protein, human KW - Receptors, Tumor Necrosis Factor, Type II KW - Resistin KW - Thiazolidinediones KW - rosiglitazone KW - 05V02F2KDG KW - C-Reactive Protein KW - 9007-41-4 KW - Index Medicus KW - Humans KW - Resistin -- blood KW - Aged KW - Receptors, Tumor Necrosis Factor, Type II -- blood KW - Interleukin-6 -- blood KW - Adult KW - Body Weight -- drug effects KW - Middle Aged KW - Insulin Resistance KW - Blood Pressure -- drug effects KW - Adolescent KW - Apolipoproteins B -- blood KW - Fatty Acids, Nonesterified -- blood KW - Biomarkers -- blood KW - Male KW - Adiponectin -- blood KW - C-Reactive Protein -- metabolism KW - Female KW - PPAR gamma -- agonists KW - Cholesterol, HDL -- blood KW - Hypoglycemic Agents -- administration & dosage KW - Thiazolidinediones -- adverse effects KW - Hypoglycemic Agents -- adverse effects KW - Metabolic Syndrome X -- immunology KW - Metabolic Syndrome X -- blood KW - Metabolic Syndrome X -- drug therapy KW - Thiazolidinediones -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67664200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.atitle=Effects+of+rosiglitazone+on+lipids%2C+adipokines%2C+and+inflammatory+markers+in+nondiabetic+patients+with+low+high-density+lipoprotein+cholesterol+and+metabolic+syndrome.&rft.au=Samaha%2C+Frederick+F%3BSzapary%2C+Philippe+O%3BIqbal%2C+Nayyar%3BWilliams%2C+Monica+M%3BBloedon%2C+LeAnne+T%3BKochar%2C+Arshneel%3BWolfe%2C+Megan+L%3BRader%2C+Daniel+J&rft.aulast=Samaha&rft.aufirst=Frederick&rft.date=2006-03-01&rft.volume=26&rft.issue=3&rft.spage=624&rft.isbn=&rft.btitle=&rft.title=Arteriosclerosis%2C+thrombosis%2C+and+vascular+biology&rft.issn=1524-4636&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-24 N1 - Date created - 2006-02-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1413-4 [16709957] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mantram repetition for stress management in veterans and employees: a critical incident study AN - 57106590; 200705821 AB - Aim. This paper reports a study assessing the usefulness of a mantram repetition programme. Background. Complementary/alternative therapies are becoming commonplace, but more research is needed to assess their benefits. A 5-week programme teaching a 'mind-body-spiritual' technique of silently repeating a mantram - a word or phrase with spiritual meaning - to manage stress was developed. A mantram was chosen by individuals, who were taught to repeat it silently throughout the day or night to interrupt unwanted thoughts and elicit the relaxation response. Methods. Participants who attended a 5-week course were invited to participate in the study. Of those who consented, a randomly selected subset (n = 66) was contacted approximately 3 months after the course for a telephone interview using the critical incident interviewing technique. Participants were asked whether the intervention was helpful or not, and if helpful, to identify situations where it was applied. Interviews were transcribed and incidents were identified and categorized to create a taxonomy of uses. The data were collected in 2001-2002. Results. Participants included 30 veterans, mostly males (97%), and 36 hospital employees, mostly females (86%). Mean age was 56 years (sd = 12.94). Fifty-five participants (83.3%) practiced the technique and reported 147 incidents where the programme was helpful. Outcomes were organized into a taxonomy of incidents using four major categories that included managing: (a) emotions other than stress (51%); (b) stress (23.8%); (c) insomnia (12.9%); and (d) unwanted thoughts (12.3%). A group of raters reviewed the categories for inter-rater reliability. Conclusions. The majority of participants from two distinct samples reported that the mantram programme was helpful in a variety of situations. The critical incident interviewing method was found to be practical, efficient, and thorough in collecting and analyzing data. Such qualitative methods contribute to understanding the benefits of mind-body complementary therapies. Tables, Figures, y. Adapted from the source document. JF - Journal of Advanced Nursing AU - Bormann, Jill E AU - Oman, Doug AU - Kemppainen, Jeanne K AU - Becker, Sheryl AU - Gershwin, Madeline AU - Kelly, Ann AD - Nursing & Patient Care Services, VA San Diego Healthcare System, CA jill.bormann@va.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 502 EP - 512 PB - Blackwell Publishing, Oxford UK VL - 53 IS - 5 SN - 0309-2402, 0309-2402 KW - alternative/complementary therapy KW - critical incident technique KW - mantram repetition KW - nursing KW - spirituality KW - stress management KW - Veterans KW - Relaxation training KW - Mind and body KW - Nurses KW - Stress management KW - Alternative medicine KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57106590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Advanced+Nursing&rft.atitle=Mantram+repetition+for+stress+management+in+veterans+and+employees%3A+a+critical+incident+study&rft.au=Bormann%2C+Jill+E%3BOman%2C+Doug%3BKemppainen%2C+Jeanne+K%3BBecker%2C+Sheryl%3BGershwin%2C+Madeline%3BKelly%2C+Ann&rft.aulast=Bormann&rft.aufirst=Jill&rft.date=2006-03-01&rft.volume=966&rft.issue=&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-05-30 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nurses; Veterans; Alternative medicine; Mind and body; Relaxation training; Stress management DO - http://dx.doi.org/10.1111/j.1365-2648.2006.03752.x ER - TY - JOUR T1 - Obesity Is a Risk Factor for Reporting Homebound Status among Community-Dwelling Older Persons AN - 20719741; 6814666 AB - OBJECTIVE: To test the a priori hypothesis that obesity is a predictor of risk for reporting homebound status. RESEARCH METHODS AND PROCEDURES: A longitudinal cohort study was conducted with 21,645 community-dwelling men and women 65 to 97 years old. A nutrition risk screen was administered baseline between 1994 and 1999 and again 3 to 4 years later. Univariate analyses identified baseline variables associated with subsequent reporting of homebound status. Multivariable logistic regression models were created to identify baseline variables that were significant independent predictors of reporting homebound status. RESULTS: At baseline, 24% of the cohort had BMI greater than or equal to 30. There were 12,834 (45% men) respondents at follow-up (68% response). Non-responders at follow-up differed little from responders except for greater baseline age (72.2 plus or minus 6.2 vs. 71.4 plus or minus 5.6 years, p < 0.001) and reporting of any functional limitations (9.2% vs. 4.9%, p < 0.001). At follow-up, those who reported homebound status (n = 169) were significantly (p < 0.001) older (80.3 plus or minus 7.3 vs. 75.1 plus or minus 5.5 years) and more likely to report functional limitations (83.4% vs. 10.8%). Univariate analyses identified 16 baseline variables that were eliminated stepwise until five significant independent predictors remained: age greater than or equal to 75 years (2.21, 1.55 to 3.15/odds ratio, 95% confidence interval), BMI greater than or equal to 35 (1.75, 1.04 to 2.96), poor appetite (2.50, 1.29 to 4.86), low income (1.59, 1.00 to 2.56), and any functional limitation (10.67, 7.36 to 15.46). DISCUSSION: Obesity remained a significant independent predictor for reporting homebound status and should be considered in screening of older populations and in the planning, implementation, and evaluation of services for homebound older persons. JF - Obesity Research AU - Jensen, Gordon L AU - Silver, Heidi J AU - Roy, Marie-Andree AU - Callahan, Eve AU - Still, Christopher AU - Dupont, William AD - Vanderbilt Center for Human Nutrition, Clinical Nutrition Research Unit, Veterans Administration Tennessee Valley Geriatric Research Education and Clinical Centers, and. Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, Tennessee. Geisinger Medical Center, Danville, Pennsylvania Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 509 EP - 517 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 14 IS - 3 SN - 1071-7323, 1071-7323 KW - Physical Education Index; Risk Abstracts KW - Obesity KW - Age KW - research methods KW - Men KW - Women KW - obesity KW - Gerontology KW - Nutrition KW - Evaluation KW - income KW - Analysis KW - Risk factors KW - Planning KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20719741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Obesity+Is+a+Risk+Factor+for+Reporting+Homebound+Status+among+Community-Dwelling+Older+Persons&rft.au=Jensen%2C+Gordon+L%3BSilver%2C+Heidi+J%3BRoy%2C+Marie-Andree%3BCallahan%2C+Eve%3BStill%2C+Christopher%3BDupont%2C+William&rft.aulast=Jensen&rft.aufirst=Gordon&rft.date=2006-03-01&rft.volume=14&rft.issue=3&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Evaluation; Obesity; Men; Risk factors; Analysis; Planning; Women; Gerontology; Nutrition; Age; research methods; income; obesity ER - TY - JOUR T1 - Duration of Colonization with Methicillin-Resistant Staphylococcus aureus Among Patients in the Intensive Care Unit: Implications for Intervention AN - 19649587; 7399758 AB - OBJECTIVES. To determine the duration of methicillin-resistant Staphylococcus aureus (MRSA) colonization or infection before entry and during hospitalization in the intensive care unit (ICU) and the characteristics of patients who tested positive for MRSA. DESIGN. Prospective observational cohort survey. SETTING. A combined medical and coronary care ICU with 16 single-bed rooms in a 427-bed tertiary care Veteran Affairs Medical Center, PATIENTS. A total of 720 ICU patients associated with 845 ICU admissions were followed up for the detection of MRSA from January 13, 2003, to October 12, 2003. MRSA colonization was detected in patients by using active surveillance cultures (ASCs) of nasal swab specimens obtained within 48 hours of ICU entry and 3 times weekly thereafter. The duration of colonization during ICU stay and before ICU entry was calculated after a review of surveillance culture results, clinical culture results, and medical history. RESULTS. Ninety-three (11.0%) of 845 ICU admissions involved patients who were colonized with MRSA at the time of ICU entry, and 21 admissions (2.5%) involved patients who acquired MRSA during ICU stay. ASCs were positive for MRSA in 84 (73.6%) of the 114 admissions associated with MRSA positivity and were the sole means of identifying MRSA in 50 cases (43.8%). More than half of the MRSA-associated admissions involved patients who were transferred from hospital wards. The total bed-days of care for 38 admissions involving patients who tested positive for MRSA before ICU entry (1131 days) was nearly 20% higher than the total bed-days of care for all admissions associated with MRSA positivity (970 days). Admissions involving MRSA-positive patients were associated with a longer length of hospitalization before ICU entry (P< .001), longer length of ICU stay(P< .001), longer overall length of hospitalization(P< .001), and greater inpatient mortality than admissions involving MRSA-negative patients (P< .001). A total of 22.8% of all bed-care days were dedicated to MRSA-positive patients in the ICU, and 55 (48.2%) of 114 admissions associated with MRSA positivity involved patients who were colonized for the duration of their ICU stay. CONCLUSIONS. In our unit, ASCs were an effective means to identify MRSA colonization among patients admitted to the ICU. Unfortunately, the majority of identified patients had long durations of stay in our own hospital before ICU entry, with prolonged MRSA colonization. Enhanced efforts to control MRSA will have to account for the prevalence of MRSA within hospital wards and to direct control efforts at these patients in the future. JF - Infection Control and Hospital Epidemiology AU - Ridenour, G A AU - Wong, E S AU - Call, MA AU - Climo, M W AD - McGuire VAMC, 1201 Broad Rock Boulevard, Section 111-C, Richmond, VA 23249, USA, michael.climo@med.va.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 271 EP - 278 VL - 27 IS - 3 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology KW - Colonization KW - Mortality KW - Intensive care units KW - Drug resistance KW - Staphylococcus aureus KW - Infection KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19649587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Duration+of+Colonization+with+Methicillin-Resistant+Staphylococcus+aureus+Among+Patients+in+the+Intensive+Care+Unit%3A+Implications+for+Intervention&rft.au=Ridenour%2C+G+A%3BWong%2C+E+S%3BCall%2C+MA%3BClimo%2C+M+W&rft.aulast=Ridenour&rft.aufirst=G&rft.date=2006-03-01&rft.volume=27&rft.issue=3&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mortality; Colonization; Intensive care units; Drug resistance; Infection; Hospitals; Staphylococcus aureus ER - TY - JOUR T1 - Television Viewing Practices and Obesity Among Women Veterans AN - 19442954; 6772345 AB - BACKGROUND: Obesity is epidemic in the U.S. and has been associated with television viewing. OBJECTIVE: To describe the association between obesity and television viewing practices among women veterans. DESIGN, SETTING AND PARTICIPANTS: Cross-sectional, mailed survey completed by 1,555 female veterans enrolled at the VA Puget Sound Health Care System in 2000. MEASUREMENTS AND METHODS: We used bivariate and multivariate analyses to assess the association of obesity (body mass index >30 kg-m super(2) based on self-reported height and weight) with self-reported number of hours of television or videos viewed per day, and frequency of eating meals or snacking while watching television, controlling for other covariates. RESULTS: Watching television >2 hours per typical day on week days and-or weekends was associated with obesity (P2 hours per day and eating or snacking while watching television were each associated with obesity (odds ratio [OR] 1.4, 95% confidence interval [CI] 1.1 to 1.8; and OR 1.3, 95% CI 1.0 to 1.7, respectively), after adjusting for demographic variables, smoking, physical activity, and depression. Results were similar when posttraumatic stress disorder was included in the model instead of depression. Women who both watched >2 hours of television per day and ate or snacked while viewing were almost twice as likely to be obese (OR 1.9, 95% CI 1.4 to 2.6). CONCLUSION: Watching television over 2 hours per day and eating while watching television were each associated with obesity among female VA patients and may be modifiable risk factors for obesity. JF - Journal of General Internal Medicine AU - Johnson, Kay M AU - Nelson, Karin M AU - Bradley, Katharine A AD - Dr. Johnson: VA Puget Sound Health Care System, Mailstop S-111-GIMC, 1660 S. Columbian Way, Seattle, WA, 98108, Kay.Johnson2@med.va.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - S76 EP - S81 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 21 IS - S3 SN - 0884-8734, 0884-8734 KW - Physical Education Index KW - Obesity KW - Measurement KW - Videotape KW - Depression KW - Eating disorders KW - Body mass KW - Women KW - Diet (weight control) KW - Height KW - Stress KW - Surveys KW - Health KW - Patients KW - Exercise KW - Demographics KW - Smoking KW - Analysis KW - Risk factors KW - Television KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19442954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+General+Internal+Medicine&rft.atitle=Television+Viewing+Practices+and+Obesity+Among+Women+Veterans&rft.au=Johnson%2C+Kay+M%3BNelson%2C+Karin+M%3BBradley%2C+Katharine+A&rft.aulast=Johnson&rft.aufirst=Kay&rft.date=2006-03-01&rft.volume=21&rft.issue=S3&rft.spage=S76&rft.isbn=&rft.btitle=&rft.title=Journal+of+General+Internal+Medicine&rft.issn=08848734&rft_id=info:doi/10.1111%2Fj.1525-1497.2006.00379.x LA - English DB - Physical Education Index N1 - Date revised - 2007-06-01 N1 - SuppNotes - Tables, 4; references, 37. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Measurement; Obesity; Videotape; Depression; Eating disorders; Body mass; Women; Diet (weight control); Surveys; Stress; Height; Patients; Health; Exercise; Demographics; Smoking; Risk factors; Analysis; Television DO - http://dx.doi.org/10.1111/j.1525-1497.2006.00379.x ER - TY - JOUR T1 - Antipsychotic-associated neuronal changes in the brain: Toxic, therapeutic, or irrelevant to the long-term outcome of schizophrenia? AN - 17078218; 6692814 AB - The increasingly wide-spread use of antipsychotics in both adults and children calls for a detailed examination of antipsychotic-associated neuronal changes in the brain, and whether these changes are toxic, therapeutic, or perhaps irrelevant to the outcome of major psychiatric disorders, especially schizophrenia. In this review we will examine the extensive evidence demonstrating both acute and longer-term antipsychotic-associated neurotoxicity and neuroplasticity, as well as the more specific cellular changes that appear to underlie these phenomena. These include changes in proteins affecting cell survival, impairment of the mitochondrial respiratory chain, increases in DNA fragmentation, injury to dendritic microtubules, increases in dopamine-generated reactive oxygen species, changes in cell morphology, and rapid induction of apoptosis. We shall also examine the correlation between these changes and alterations in gross brain structure. There appears to be a disjunction between the widespread cellular and gross structural brain changes in schizophrenia, and the duration of illness, expression of symptoms, and response to treatment. We shall explore possible explanations for this apparent paradox. JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry AU - Dean, Charles E AD - Tardive Dyskinesia Assessment Clinic, Minneapolis VA Medical Center, One Veterans Drive, Minneapolis Minnesota 55417, USA, charles.dean@med.va.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 174 EP - 189 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 30 IS - 2 SN - 0278-5846, 0278-5846 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Antipsychotics KW - Atypical antipsychotics KW - Neuroplasticity KW - Neurotoxicity KW - Schizophrenia KW - Structural brain changes KW - Cell survival KW - Microtubules KW - Apoptosis KW - Injuries KW - Brain KW - Mitochondria KW - Children KW - Disjunction KW - DNA fragmentation KW - Mental disorders KW - Reactive oxygen species KW - Reviews KW - Neuroleptics KW - Cytology KW - Plasticity (dendritic) KW - Electron transport KW - X 24310:Pharmaceuticals KW - N3 11047:Neuropsychobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17078218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+Neuro-Psychopharmacology+and+Biological+Psychiatry&rft.atitle=Antipsychotic-associated+neuronal+changes+in+the+brain%3A+Toxic%2C+therapeutic%2C+or+irrelevant+to+the+long-term+outcome+of+schizophrenia%3F&rft.au=Dean%2C+Charles+E&rft.aulast=Dean&rft.aufirst=Charles&rft.date=2006-03-01&rft.volume=30&rft.issue=2&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Progress+in+Neuro-Psychopharmacology+and+Biological+Psychiatry&rft.issn=02785846&rft_id=info:doi/10.1016%2Fj.pnpbp.2005.08.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Microtubules; Apoptosis; Injuries; Brain; Mitochondria; Children; Disjunction; Schizophrenia; DNA fragmentation; Mental disorders; Reactive oxygen species; Neuroleptics; Reviews; Neurotoxicity; Cytology; Plasticity (dendritic); Electron transport DO - http://dx.doi.org/10.1016/j.pnpbp.2005.08.019 ER - TY - JOUR T1 - Brief communication: Better ways to question patients about adverse medical events: a randomized, controlled trial. AN - 67675703; 16490911 AB - There is no standard method of identifying adverse events in clinical trials. To determine whether 3 different methods of questioning patients about adverse events in a clinical trial affect the frequency of reported events. Randomized, single-blind, controlled trial. A Veterans Administration medical center, San Francisco, California. Men 50 years of age or older who had benign prostatic hyperplasia. Frequency of self-reported medical problems. The authors randomly assigned 214 men who were undergoing a 1-month, single-blind, placebo run-in period during an existing clinical trial to 3 groups to test different self-administered methods of assessing medical problems at the end of the run-in period. The first group was asked an open-ended question; the second group was asked an open-ended, defined question; and the third group was given a checklist of 53 common side effects. All 214 patients completed the study. Patients assigned to the checklist group reported a total of 238 adverse events; in comparison, patients who were asked an open-ended question or an open-ended, defined question reported 11 and 14 adverse events, respectively (P < 0.001). The percentage of patients reporting any adverse event was also much higher in the group assigned to the checklist (77%) than in the first group (14%) or second group (13%) (P < 0.001). The study included only relatively healthy, well-educated, middle-aged men and assessed only self-reported medical problems after the participants had taken placebo for 1 month. All personnel overseeing the study were aware of the group assignments. Different methods of collecting patient data regarding adverse events lead to large differences in the reported rates of adverse events in clinical trials, potentially reducing the validity of comparisons between the side effect profiles of drugs and other interventions. JF - Annals of internal medicine AU - Bent, Stephen AU - Padula, Amy AU - Avins, Andrew L AD - University of California and San Francisco Veterans Administration Medical Center, San Francisco, California 94121, USA. bent@itsa.ucsf.edu Y1 - 2006/02/21/ PY - 2006 DA - 2006 Feb 21 SP - 257 EP - 261 VL - 144 IS - 4 KW - Abridged Index Medicus KW - Index Medicus KW - Single-Blind Method KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Surveys and Questionnaires -- standards KW - Drug-Related Side Effects and Adverse Reactions KW - Randomized Controlled Trials as Topic -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67675703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Brief+communication%3A+Better+ways+to+question+patients+about+adverse+medical+events%3A+a+randomized%2C+controlled+trial.&rft.au=Bent%2C+Stephen%3BPadula%2C+Amy%3BAvins%2C+Andrew+L&rft.aulast=Bent&rft.aufirst=Stephen&rft.date=2006-02-21&rft.volume=144&rft.issue=4&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-14 N1 - Date created - 2006-02-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Intern Med. 2006 Feb 21;144(4):298-300 [16490917] Erratum In: Ann Intern Med. 2006 Jul 18;145(2):156 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transposome mutagenesis of an integral membrane transporter in Corynebacterium matruchotii AN - 17077591; 6710511 AB - A transposon-5 insertion library of Corynebacterium matruchotii ATCC14266 was generated and screened for mutants with altered corynomycolic acid content. One of these designated 319 mutants showed an interruption of a gene encoding an integral membrane protein. MALDI mass spectra of trehalose monocorynomycolate (TMCM), trehalose dicorynomycolate, and methyl corynomycolates derived from cell wall arabinogalactan-corynomycolate showed that these lipids from the mutant contained a lower amount of short-chain (C sub(2) sub(4) to C sub(3) sub(4)) and much greater amount of long-chain (primarily C sub(3) sub(6) sub(:) sub(2)) corynomycolic acids than the wild type. An analysis of mRNA demonstrated that the integral membrane protein and ATP-binding cassette transporter are transcriptionally coupled. These results suggested that the proteins/enzymes encoded by the membrane transporter gene locus preferably move short-chain corynomycolic acids from the cytoplasm across the membrane bilayer to the periplasmic space where the synthesis of TMCM is thought to occur. This is the first evidence linking corynomycolic acid to a transporter gene locus. JF - Biochemical and Biophysical Research Communications AU - Wang, C AU - Hayes, B AU - Vestling, M M AU - Takayama, K AD - William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA, Kuni.Takayama@med.va.gov Y1 - 2006/02/17/ PY - 2006 DA - 2006 Feb 17 SP - 953 EP - 960 VL - 340 IS - 3 SN - 0006-291X, 0006-291X KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Periplasmic space KW - Lipids KW - ATP-binding protein KW - Cytoplasm KW - Transcription KW - Enzymes KW - Corynebacterium matruchotii KW - Trehalose KW - Membrane proteins KW - Cell walls KW - Mutagenesis KW - N 14810:Methods KW - G 07770:Bacteria KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17077591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Transposome+mutagenesis+of+an+integral+membrane+transporter+in+Corynebacterium+matruchotii&rft.au=Wang%2C+C%3BHayes%2C+B%3BVestling%2C+M+M%3BTakayama%2C+K&rft.aulast=Wang&rft.aufirst=C&rft.date=2006-02-17&rft.volume=340&rft.issue=3&rft.spage=953&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2005.12.097 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Periplasmic space; Cytoplasm; ATP-binding protein; Lipids; Enzymes; Transcription; Membrane proteins; Trehalose; Mutagenesis; Cell walls; Corynebacterium matruchotii DO - http://dx.doi.org/10.1016/j.bbrc.2005.12.097 ER - TY - CPAPER T1 - Success Under Pressure: Strategies to Reduce Musculoskeletal Injuries in the Hospital Setting T2 - 10th Annual Meeting of the Biofeedback Foundation of Europe AN - 39933566; 4158792 JF - 10th Annual Meeting of the Biofeedback Foundation of Europe AU - Frobish, Candy AU - Peper, Erik Y1 - 2006/02/14/ PY - 2006 DA - 2006 Feb 14 KW - Musculoskeletal system KW - Hospitals KW - Injuries KW - Pressure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39933566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Annual+Meeting+of+the+Biofeedback+Foundation+of+Europe&rft.atitle=Success+Under+Pressure%3A+Strategies+to+Reduce+Musculoskeletal+Injuries+in+the+Hospital+Setting&rft.au=Frobish%2C+Candy%3BPeper%2C+Erik&rft.aulast=Frobish&rft.aufirst=Candy&rft.date=2006-02-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Annual+Meeting+of+the+Biofeedback+Foundation+of+Europe&rft.issn=&rft_id=info:doi/ L2 - http://www.bfe.org/meeting/SCIENTIFIC%20PROGRAM%20ON%20WEB.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dlk1 and MNDA Protein Expression in Myeloid Progenitors: Utility of Dlk1 as an Immunohistochemical Marker of the Megakaryocytic Lineage T2 - 95th Annual Meeting of the United States and Canadian Academy of Pathology AN - 39826522; 4102365 JF - 95th Annual Meeting of the United States and Canadian Academy of Pathology AU - McClintock-Treep, S A AU - Jagasia, M H AU - Goodman, S A AU - Briggs, R C AU - Head, D R Y1 - 2006/02/11/ PY - 2006 DA - 2006 Feb 11 KW - Stem cells KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39826522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Dlk1+and+MNDA+Protein+Expression+in+Myeloid+Progenitors%3A+Utility+of+Dlk1+as+an+Immunohistochemical+Marker+of+the+Megakaryocytic+Lineage&rft.au=McClintock-Treep%2C+S+A%3BJagasia%2C+M+H%3BGoodman%2C+S+A%3BBriggs%2C+R+C%3BHead%2C+D+R&rft.aulast=McClintock-Treep&rft.aufirst=S&rft.date=2006-02-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=95th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://www.uscap.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Outcomes of clinical trial: tinnitus masking versus tinnitus retraining therapy. AN - 85388740; pmid-16640064 AB - A controlled clinical study was conducted to evaluate prospectively the clinical efficacy of tinnitus masking (TM) and tinnitus retraining therapy (TRT) in military veterans having clinically significant tinnitus. Qualifying patients were placed into the two groups in an alternating manner (to avoid selection bias), and treatment was administered at 0, 3, 6, 12, and 18 months. Outcomes of treatment were evaluated using three self-administered tinnitus questionnaires (Tinnitus Handicap Inventory, Tinnitus Handicap Questionnaire, Tinnitus Severity Index) and the verbally administered TRT interview forms. Findings are presented from the three written questionnaires, and from two of the interview questions (percentage time aware of, and annoyed by, tinnitus). Outcomes were analyzed on an intent-to-treat basis, using a multilevel modeling approach. Of the 123 patients enrolled, 118 were included in the analysis. Both groups showed significant declines (improvements) on these measures, with the TRT decline being significantly greater than for TM. The greater declines in TRT compared to TM occurred most strongly in patients who began treatment with a "very big" tinnitus problem. When patients began treatment with a "moderate" tinnitus problem, the benefits of TRT compared to TM were more modest. JF - Journal of the American Academy of Audiology AU - Henry, James A AU - Schechter, Martin A AU - Zaugg, Tara L AU - Griest, Susan AU - Jastreboff, Pawel J AU - Vernon, Jack A AU - Kaelin, Christine AU - Meikle, Mary B AU - Lyons, Karen S AU - Stewart, Barbara J AD - VA RR&D National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Oregon, USA. james.henry@med.va.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 104 EP - 132 VL - 17 IS - 2 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - *Acoustic Stimulation KW - Analysis of Variance KW - Female KW - Follow-Up Studies KW - Humans KW - Male KW - Middle Aged KW - *Perceptual Masking KW - Predictive Value of Tests KW - Prospective Studies KW - Questionnaires KW - *Tinnitus: therapy KW - Treatment Outcome KW - Veterans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85388740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Outcomes+of+clinical+trial%3A+tinnitus+masking+versus+tinnitus+retraining+therapy.&rft.au=Henry%2C+James+A%3BSchechter%2C+Martin+A%3BZaugg%2C+Tara+L%3BGriest%2C+Susan%3BJastreboff%2C+Pawel+J%3BVernon%2C+Jack+A%3BKaelin%2C+Christine%3BMeikle%2C+Mary+B%3BLyons%2C+Karen+S%3BStewart%2C+Barbara+J&rft.aulast=Henry&rft.aufirst=James&rft.date=2006-02-01&rft.volume=17&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Effects of oxandrolone, an anabolic steroid, on hemostasis. AN - 70715366; 16432848 AB - This study evaluated the short-term effects of oxandrolone, an anabolic androgenic synthetic steroid, on blood coagulation and the hemostatic/fibrinolytic system in healthy individuals. Subjects (n = 14) were administered oxandrolone (10 mg twice daily) for 14 days. Blood was obtained on days 0, 1, 3, 7, 9, 14, and then at day 42 (28 days after discontinuation of the drug). Samples were analyzed for the plasma plasminogen, plasminogen activator inhibitor (PAI-1), fibrinogen, and coagulation factors (II, V, VII, VIII, and X). After 7 days of administration of oxandrolone, the plasma plasminogen level significantly increased [100% +/- 21% to 174% +/- 21% (P < 0.0001)]. PAI-1 was significantly decreased at day 3 [16 +/- 9 to 7 +/- 4 mg/dL (P < 0.01)]. Coagulation factors II and V significantly increased at day 14 [88 +/- 15 to 122 +/- 11 (P < 0.005) and 105 +/- 21 to 179 +/- 36% (P < 0.0001)], respectively. Factor VII level decreased by day 3 [91% +/- 26% to 83% +/- 18%, NS], but after 14 days factor VII level returned to baseline (91% +/- 26% to 93% +/- 19%, NS). The increase of factor VIII level was not significant (111% +/- 64% to 125% +/- 55%, NS). Factor X increased steadily over 14 days of drug treatment [96% +/- 11% to 107% +/- 25%, NS] and after discontinuation, decreased and returned to baseline by day 42 [107% +/- 25% to 89% +/- 25%, NS]. Fibrinogen decreased by 22% +/- 12%, (NS). Administration of oxandrolone, to healthy young men was associated with a significant increase in select blood coagulation factors and plasminogen. These changes create a state of potential hypercoagulability that appears to be counterbalanced by increased fibrinolytic activity to maintain homeostasis. 2006 Wiley-Liss, Inc. JF - American journal of hematology AU - Kahn, Nighat N AU - Sinha, Asru K AU - Spungen, Ann M AU - Bauman, William A AD - Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA. nighat.kahn@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 95 EP - 100 VL - 81 IS - 2 SN - 0361-8609, 0361-8609 KW - Anabolic Agents KW - 0 KW - Biomarkers KW - Blood Coagulation Factors KW - Plasminogen Activator Inhibitor 1 KW - SERPINE1 protein, human KW - Steroids KW - Oxandrolone KW - 7H6TM3CT4L KW - Plasminogen KW - 9001-91-6 KW - Index Medicus KW - Humans KW - Adult KW - Plasminogen Activator Inhibitor 1 -- blood KW - Fibrinolysis -- drug effects KW - Steroids -- pharmacology KW - Steroids -- administration & dosage KW - Middle Aged KW - Blood Coagulation Factors -- analysis KW - Thrombophilia -- chemically induced KW - Plasminogen -- analysis KW - Biomarkers -- blood KW - Male KW - Anabolic Agents -- pharmacology KW - Oxandrolone -- administration & dosage KW - Hemostasis -- drug effects KW - Oxandrolone -- pharmacology KW - Anabolic Agents -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70715366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hematology&rft.atitle=Effects+of+oxandrolone%2C+an+anabolic+steroid%2C+on+hemostasis.&rft.au=Kahn%2C+Nighat+N%3BSinha%2C+Asru+K%3BSpungen%2C+Ann+M%3BBauman%2C+William+A&rft.aulast=Kahn&rft.aufirst=Nighat&rft.date=2006-02-01&rft.volume=81&rft.issue=2&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hematology&rft.issn=03618609&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-14 N1 - Date created - 2006-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The efficacy of olanzapine for decreasing cue-elicited craving in individuals with schizophrenia and cocaine dependence: a preliminary report. AN - 70695304; 16415698 AB - Although a growing body of research suggests that atypical neuroleptic medications are efficacious in the treatment of cocaine addiction among individuals with schizophrenia, more rigorously controlled trials are needed. To extend this research, we performed a 6-week double-blind study comparing olanzapine to haloperidol with the primary objective of reducing cue-elicited cocaine craving and the secondary aims of decreasing substance use, improving psychiatric symptoms, and determining an effect size for future studies. Thirty-one subjects with cocaine dependence and schizophrenia were randomized to olanzapine or haloperidol, underwent a cue-exposure procedure, and completed psychiatric and substance abuse ratings. Individuals in the olanzapine group who completed the study had a significant reduction on the energy subscale of the Voris Cocaine Craving Scale at study completion compared with individuals in the haloperidol group. The olanzapine-treated group also had lower, but not statistically significant, PANSS General Psychopathology Subscale scores and fewer positive urine toxicology screens compared with those in the haloperidol group. This small, but rigorously controlled, pilot trial provides additional evidence for the use of atypical antipsychotics for the treatment of individuals with co-occurring schizophrenia and cocaine dependence. Reductions in craving were associated with medium to large effect sizes. JF - Journal of clinical psychopharmacology AU - Smelson, David A AU - Ziedonis, Douglas AU - Williams, John AU - Losonczy, Miklos F AU - Williams, Jill AU - Steinberg, Marc L AU - Kaune, Maureen AD - Department of Veterans Affairs, New Jersey Health Care System, Lyons, NJ 07939-5000, USA. David.Smelson@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 9 EP - 12 VL - 26 IS - 1 SN - 0271-0749, 0271-0749 KW - Antipsychotic Agents KW - 0 KW - Benzodiazepines KW - 12794-10-4 KW - Haloperidol KW - J6292F8L3D KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - Haloperidol -- therapeutic use KW - Benzodiazepines -- therapeutic use KW - Psychiatric Status Rating Scales KW - Double-Blind Method KW - Humans KW - Adult KW - Cues KW - Pilot Projects KW - Behavior, Addictive -- drug therapy KW - Antipsychotic Agents -- therapeutic use KW - Cocaine-Related Disorders -- drug therapy KW - Schizophrenia -- drug therapy KW - Schizophrenia -- complications KW - Cocaine-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70695304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=The+efficacy+of+olanzapine+for+decreasing+cue-elicited+craving+in+individuals+with+schizophrenia+and+cocaine+dependence%3A+a+preliminary+report.&rft.au=Smelson%2C+David+A%3BZiedonis%2C+Douglas%3BWilliams%2C+John%3BLosonczy%2C+Miklos+F%3BWilliams%2C+Jill%3BSteinberg%2C+Marc+L%3BKaune%2C+Maureen&rft.aulast=Smelson&rft.aufirst=David&rft.date=2006-02-01&rft.volume=26&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-03 N1 - Date created - 2006-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oxymorphone: a review. AN - 70689841; 16317569 AB - Oxymorphone (oxymorphone hydrochloride) (14-hydroxy-dihydromorphinone), a semisynthetic mu-opioid agonist, was first approved by the US Food and Drug Administration in 1959. Oxymorphone is considered a more potent opioid than its parent compound, morphine. Recently, an immediate-release and long-acting oral formulation of this drug was developed that makes oxymorphone a new option in treating moderate to severe pain. This article reviews the pharmacodynamics, pharmacology, and clinical efficacy for this new option in treating moderate to severe pain. JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer AU - Prommer, Eric AD - VIP Palliative Care Program Greater Los Angeles Healthcare, Division of Hematology/Oncology, UCLA School of Medicine, 11301 Wilshire 111-H, Los Angeles, CA, USA. eric.prommer@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 109 EP - 115 VL - 14 IS - 2 SN - 0941-4355, 0941-4355 KW - Analgesics, Opioid KW - 0 KW - Oxymorphone KW - 9VXA968E0C KW - Index Medicus KW - Drug Interactions KW - Drug Administration Schedule KW - Neoplasms -- complications KW - Humans KW - Oxymorphone -- adverse effects KW - Pain -- drug therapy KW - Oxymorphone -- pharmacokinetics KW - Analgesics, Opioid -- pharmacology KW - Oxymorphone -- pharmacology KW - Analgesics, Opioid -- therapeutic use KW - Oxymorphone -- therapeutic use KW - Oxymorphone -- administration & dosage KW - Analgesics, Opioid -- pharmacokinetics KW - Analgesics, Opioid -- adverse effects KW - Analgesics, Opioid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70689841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.atitle=Oxymorphone%3A+a+review.&rft.au=Prommer%2C+Eric&rft.aulast=Prommer&rft.aufirst=Eric&rft.date=2006-02-01&rft.volume=14&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.issn=09414355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-16 N1 - Date created - 2006-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatitis C and hospital outcomes in patients admitted with alcohol-related problems. AN - 70686874; 16226823 AB - Alcohol is known to act synergistically with chronic hepatitis C virus (HCV) infection to cause liver disease; however, their combined effect on outcomes in acutely hospitalized patients is less clear. We examined the impact of HCV infection on hospital mortality and length of stay among hospitalized patients with alcohol abuse problems. We retrospectively identified 6354 admissions to an urban, public hospital between July 1996 and January 2002 with discharge diagnoses related to alcohol dependence or abuse. Hepatitis C diagnosis and other information were extracted from a clinical database and tested for associations with death and length of hospital stay using multivariable regression techniques. The prevalence of diagnosed HCV infection in this sample of patients with alcohol abuse was 15%. Patients with HCV were about twice as likely to die during hospital admission (4.4 vs. 2.4%; P-value < 0.01), and there appeared to be a trend toward increased mortality even after adjustment for demographics, medical service, homelessness and comorbidities (fully adjusted OR 1.41; 95% CI: 0.97-2.04). Length of stay was significantly longer for patients with HCV (19% longer; 95% CI: 12-27% after adjustment) than those without. Patients admitted to the hospital with alcohol-related diagnoses have longer hospital stays and are more likely to die in hospital if they have a diagnosis of HCV. JF - Journal of hepatology AU - Tsui, Judith I AU - Pletcher, Mark J AU - Vittinghoff, Eric AU - Seal, Karen AU - Gonzales, Ralph AD - Division of General Medicine, General Internal Medicine Section (111A1), San Francisco Veteran Administration Medical Center, University of California, 4150 Clement Street, San Francisco, CA 94121, USA. judith.tsui@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 262 EP - 266 VL - 44 IS - 2 SN - 0168-8278, 0168-8278 KW - Index Medicus KW - Humans KW - Adult KW - Retrospective Studies KW - Prognosis KW - Middle Aged KW - California -- epidemiology KW - Male KW - Female KW - Prevalence KW - Length of Stay -- statistics & numerical data KW - Inpatients -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Hepatitis C, Chronic -- epidemiology KW - Hepatitis C, Chronic -- complications KW - Patient Admission -- statistics & numerical data KW - Hospital Mortality -- trends KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70686874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=Hepatitis+C+and+hospital+outcomes+in+patients+admitted+with+alcohol-related+problems.&rft.au=Tsui%2C+Judith+I%3BPletcher%2C+Mark+J%3BVittinghoff%2C+Eric%3BSeal%2C+Karen%3BGonzales%2C+Ralph&rft.aulast=Tsui&rft.aufirst=Judith&rft.date=2006-02-01&rft.volume=44&rft.issue=2&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=01688278&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-25 N1 - Date created - 2006-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug-associated renal dysfunction and injury. AN - 68791371; 16932399 AB - Renal dysfunction and injury secondary to medications are common, and can present as subtle injury and/or overt renal failure. Some drugs perturb renal perfusion and induce loss of filtration capacity. Others directly injure vascular, tubular, glomerular and interstitial cells, such that specific loss of renal function leads to clinical findings, including microangiopathy, Fanconi syndrome, acute tubular necrosis, acute interstitial nephritis, nephrotic syndrome, obstruction, nephrogenic diabetes insipidus, electrolyte abnormalities and chronic renal failure. Understanding the mechanisms involved, and recognizing the clinical presentations of renal dysfunction arising from use of commonly prescribed medications, are important if injury is to be detected early and prevented. This article reviews the clinical features and basic processes underlying renal injury related to the use of common drugs. JF - Nature clinical practice. Nephrology AU - Choudhury, Devasmita AU - Ahmed, Ziauddin AD - University of Texas Southwestern Medical Center, Dallas, TX, USA. devasmita.dev@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 80 EP - 91 VL - 2 IS - 2 SN - 1745-8323, 1745-8323 KW - Index Medicus KW - Humans KW - Renal Insufficiency -- chemically induced KW - Drug-Related Side Effects and Adverse Reactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68791371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+clinical+practice.+Nephrology&rft.atitle=Drug-associated+renal+dysfunction+and+injury.&rft.au=Choudhury%2C+Devasmita%3BAhmed%2C+Ziauddin&rft.aulast=Choudhury&rft.aufirst=Devasmita&rft.date=2006-02-01&rft.volume=2&rft.issue=2&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Nature+clinical+practice.+Nephrology&rft.issn=17458323&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-14 N1 - Date created - 2006-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lessons learned about implementing research evidence into clinical practice. Experiences from VA QUERI. AN - 67905777; 16637956 AB - The mission of the Veterans Health Administration's (VHA) quality enhancement research initiative (QUERI) is to enhance the quality of VHA health care by implementing clinical research findings into routine care. This paper presents lessons that QUERI investigators have learned through their initial attempts to pursue the QUERI mission. The lessons in this paper represent those that were common across multiple QUERI projects and were mutually agreed on as having substantial impact on the success of implementation. While the lessons are consistent with commonly recognized ingredients of successful implementation efforts, the examples highlight the fact that, even with a thorough knowledge of the literature and thoughtful planning, unexpected circumstances arise during implementation efforts that require flexibility and adaptability. The findings stress the importance of utilizing formative evaluation techniques to identify barriers to successful implementation and strategies to address these barriers. JF - Journal of general internal medicine AU - Hagedorn, Hildi AU - Hogan, Mary AU - Smith, Jeffrey L AU - Bowman, Candice AU - Curran, Geoffrey M AU - Espadas, Donna AU - Kimmel, Barbara AU - Kochevar, Laura AU - Legro, Marcia W AU - Sales, Anne E AD - Substance Use Disorders QUERI, Minneapolis VA Medical Center, Minneapolis, MN 55417, USA. Hildi.Hagedorn@va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - S21 EP - S24 VL - 21 Suppl 2 KW - Narcotics KW - 0 KW - Index Medicus KW - United States KW - Practice Patterns, Physicians' KW - United States Department of Veterans Affairs KW - Humans KW - Community Networks -- organization & administration KW - Narcotics -- therapeutic use KW - Narcotics -- agonists KW - Hospitals, Veterans -- standards KW - Benchmarking KW - Opioid-Related Disorders -- drug therapy KW - Practice Guidelines as Topic -- standards KW - Evidence-Based Medicine KW - Total Quality Management KW - Outcome Assessment (Health Care) -- methods KW - Health Services Research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67905777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+general+internal+medicine&rft.atitle=Lessons+learned+about+implementing+research+evidence+into+clinical+practice.+Experiences+from+VA+QUERI.&rft.au=Hagedorn%2C+Hildi%3BHogan%2C+Mary%3BSmith%2C+Jeffrey+L%3BBowman%2C+Candice%3BCurran%2C+Geoffrey+M%3BEspadas%2C+Donna%3BKimmel%2C+Barbara%3BKochevar%2C+Laura%3BLegro%2C+Marcia+W%3BSales%2C+Anne+E&rft.aulast=Hagedorn&rft.aufirst=Hildi&rft.date=2006-02-01&rft.volume=21+Suppl+2&rft.issue=&rft.spage=S21&rft.isbn=&rft.btitle=&rft.title=Journal+of+general+internal+medicine&rft.issn=1525-1497&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-09 N1 - Date created - 2006-04-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Jt Comm J Qual Patient Saf. 2005 Dec;31(12):700-7 [16430023] Milbank Q. 2004;82(4):581-629 [15595944] Worldviews Evid Based Nurs. 2004;1(2):129-39 [17129326] Worldviews Evid Based Nurs. 2004;1 Suppl 1:S33-40 [17129333] J Gen Intern Med. 2006 Feb;21 Suppl 2:S1-8 [16637954] Med Care. 2000 Jun;38(6 Suppl 1):I17-25 [10843267] Med Care. 2002 Dec;40(12):1270-82 [12458308] J Am Med Inform Assoc. 2004 Jan-Feb;11(1):50-9 [14527974] J Spinal Cord Med. 2003 Fall;26(3):210-8 [14997959] J Acquir Immune Defic Syndr. 2004 Mar 1;35(3):253-60 [15076239] Am J Med. 2004 Jun 1;116(11):732-9 [15144909] Drug Alcohol Depend. 2004 Jul 15;75(1):97-106 [15225893] J Am Med Inform Assoc. 2004 Sep-Oct;11(5):339-43 [15187071] J Am Med Inform Assoc. 2004 Sep-Oct;11(5):351-7 [15187073] Am J Med Qual. 2004 Jul-Aug;19(4):137-44 [15368778] Comment In: J Gen Intern Med. 2006 Feb;21 Suppl 2:S67-70 [16637964] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Palliative ethanol injections of unresectable advanced esophageal carcinoma combined with chemoradiation. AN - 67663950; 16479188 AB - Combined chemoradiation therapy has proven to be an effective treatment for unresectable esophageal cancer. Nonsurgical endoscopic palliation of local disease has become feasible with neodymium:yttrium-aluminum-garnet laser, BICAP tumor probe, and metallic stents. Alternatively, endoscopic injections of ethanol are safe, inexpensive, and useful for palliation of malignant dysphagia. Two patients with unresectable squamous cell carcinoma of the esophagus were treated with 1 mL of absolute (95 g/L) alcohol injections once a week for 4 weeks, followed by chemoradiation therapy consisting of concomitant 5-fluorouracil 300 mg/m/d and radiation therapy (total of 60 Gy over 6 weeks). One patient had a complete response but died of alcoholism 25 months after diagnosis without evidence of tumor recurrence. The other patient had a partial response but died 16 months after diagnosis from disease progression. We conclude that tumor ablation by ethanol injection for palliation combined with chemoradiation may be a low-cost alternative for advanced unresectable esophageal cancer. JF - The American journal of the medical sciences AU - Wadleigh, Robert G AU - Abbasi, Salah AU - Korman, Louis AD - Oncology Section, Department of Veterans Affairs Medical Center, Washington, DC, USA. Robert.Wadleigh@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 110 EP - 112 VL - 331 IS - 2 SN - 0002-9629, 0002-9629 KW - Antimetabolites, Antineoplastic KW - 0 KW - Ethanol KW - 3K9958V90M KW - Fluorouracil KW - U3P01618RT KW - Abridged Index Medicus KW - Index Medicus KW - Fluorouracil -- therapeutic use KW - Radiation Dosage KW - Fatal Outcome KW - Neoplasm Staging KW - Combined Modality Therapy KW - Humans KW - Aged KW - Middle Aged KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Male KW - Ethanol -- administration & dosage KW - Esophageal Neoplasms -- radiotherapy KW - Carcinoma, Squamous Cell -- radiotherapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Palliative Care -- methods KW - Ethanol -- therapeutic use KW - Esophageal Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67663950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Palliative+ethanol+injections+of+unresectable+advanced+esophageal+carcinoma+combined+with+chemoradiation.&rft.au=Wadleigh%2C+Robert+G%3BAbbasi%2C+Salah%3BKorman%2C+Louis&rft.aulast=Wadleigh&rft.aufirst=Robert&rft.date=2006-02-01&rft.volume=331&rft.issue=2&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-16 N1 - Date created - 2006-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Combination exposure to zidovudine plus sulfamethoxazole-trimethoprim diminishes B-lymphocyte immune responses to Pneumocystis murina infection in healthy mice. AN - 67644807; 16467325 AB - We have previously shown that zidovudine plus sulfamethoxazole-trimethoprim exposure decreases immune cell populations in the bone marrow of healthy mice by inducing apoptosis. The hypothesis of the current work was that this toxicity would have an adverse impact on the immune response. To determine this, BALB/c mice were treated with zidovudine, sulfamethoxazole-trimethoprim, the combination of both drugs, or vehicle only (control) via oral gavage for 21 days. On day 4 after dosing completion, the mice were infected intratracheally with 1x10(7) Pneumocystis murina organisms. Immune cell populations (in lung digest, bronchoalveolar lavage fluid, tracheobronchial lymph node, and bone marrow samples), the lung Pneumocystis burden, and serum Pneumocystis-specific antibody titers were determined at days 6, 10, and 20 postinfection. While total bone marrow cellularity was recovered by day 6 postinfection in the combination exposure group, B-cell numbers did not recover until 10 days postinfection, primarily due to the persistent depletion of the late pre-B-cell phenotype. The numbers of CD4+ and CD8+ T cells, as well as the numbers of total B cells and activated B cells in tracheobronchial lymph nodes, were decreased at days 10 and 20 as a result of zidovudine plus sulfamethoxazole-trimethoprim exposure compared to the numbers in the control group. No significant differences in lung lavage or lung digest cell populations were observed. There was a trend of a delay in Pneumocystis clearance in the combination treatment group, and Pneumocystis-specific serum immunoglobulin G titers were reduced at day 20 postinfection. Together, these data indicate that the combination of zidovudine and sulfamethoxazole-trimethoprim adversely affects the humoral immune response to Pneumocystis. JF - Clinical and vaccine immunology : CVI AU - Feola, David J AU - Garvy, Beth A AD - Department of Pharmacy Practice and Science, University of Kentucky Chandler Medical Center, and Veterans Administration Medical Center, Lexington, KY 40536-0298, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 193 EP - 201 VL - 13 IS - 2 SN - 1556-6811, 1556-6811 KW - Antibodies, Fungal KW - 0 KW - Immunoglobulin G KW - Zidovudine KW - 4B9XT59T7S KW - Trimethoprim, Sulfamethoxazole Drug Combination KW - 8064-90-2 KW - Index Medicus KW - Pneumocystis -- immunology KW - Lung -- immunology KW - Immunoglobulin G -- blood KW - Immune Tolerance -- drug effects KW - Animals KW - Drug Interactions KW - Mice KW - Antibodies, Fungal -- blood KW - Mice, Inbred BALB C KW - Bone Marrow -- drug effects KW - Lung -- microbiology KW - Trimethoprim, Sulfamethoxazole Drug Combination -- administration & dosage KW - B-Lymphocytes -- drug effects KW - Pneumonia, Pneumocystis -- immunology KW - Pneumonia, Pneumocystis -- drug therapy KW - Zidovudine -- toxicity KW - Pneumonia, Pneumocystis -- microbiology KW - B-Lymphocytes -- microbiology KW - Trimethoprim, Sulfamethoxazole Drug Combination -- toxicity KW - Zidovudine -- administration & dosage KW - B-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67644807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+vaccine+immunology+%3A+CVI&rft.atitle=Combination+exposure+to+zidovudine+plus+sulfamethoxazole-trimethoprim+diminishes+B-lymphocyte+immune+responses+to+Pneumocystis+murina+infection+in+healthy+mice.&rft.au=Feola%2C+David+J%3BGarvy%2C+Beth+A&rft.aulast=Feola&rft.aufirst=David&rft.date=2006-02-01&rft.volume=13&rft.issue=2&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Clinical+and+vaccine+immunology+%3A+CVI&rft.issn=15566811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-10 N1 - Date created - 2006-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet. 1989 Dec 2;2(8675):1294-8 [2574255] Health Phys. 1989;57 Suppl 1:405-9 [2606699] Science. 1990 Feb 2;247(4942):564-6 [2300816] N Engl J Med. 1990 Apr 5;322(14):941-9 [1969115] Ann Intern Med. 1990 May 15;112(10):727-37 [1970466] J Exp Med. 1990 Sep 1;172(3):937-45 [2117637] Drug Metab Dispos. 1990 Sep-Oct;18(5):784-7 [1981737] N Engl J Med. 1991 Apr 11;324(15):1018-25 [1672443] J Exp Med. 1991 May 1;173(5):1213-25 [1827140] Lancet. 1991 Aug 17;338(8764):431-3 [1678095] N Engl J Med. 1983 Jun 23;308(25):1535-6 [6222258] N Engl J Med. 1983 Aug 25;309(8):453-8 [6224088] JAMA. 1984 Mar 16;251(11):1447-9 [6608011] Ann Intern Med. 1984 Apr;100(4):495-9 [6230976] Ann Intern Med. 1984 May;100(5):663-71 [6231873] Am Rev Respir Dis. 1984 Dec;130(6):1174-6 [6508012] Clin Exp Pharmacol Physiol. 1995 Nov;22(11):851-4 [8593743] J Infect Dis. 1996 Apr;173(4):1034-7 [8603947] Med J Aust. 1996 Mar 4;164(5):290-5 [8628165] Infect Immun. 1996 Jun;64(6):1892-9 [8675284] Transplantation. 1996 Aug 27;62(4):517-25 [8781619] Infect Immun. 1996 Oct;64(10):3987-92 [8926059] Eur J Drug Metab Pharmacokinet. 1996 Jul-Sep;21(3):275-8 [8980928] J Clin Invest. 1997 May 1;99(9):2110-7 [9151783] AIDS Res Hum Retroviruses. 1997 Aug 10;13(12):1023-9 [9264289] Drug Metab Dispos. 1991 Sep-Oct;19(5):900-6 [1686233] J Protozool. 1991 Nov-Dec;38(6):44S-45S [1687826] J Clin Invest. 1992 Aug;90(2):673-8 [1353767] J Infect Dis. 1993 Jan;167(1):180-5 [8380290] Chest. 1993 Feb;103(2 Suppl):116S-118S [8094045] Clin Exp Immunol. 1993 Oct;94(1):21-5 [8403509] Am J Med. 1994 Jan;96(1):94-5 [8304370] Toxicol Appl Pharmacol. 1995 Mar;131(1):53-62 [7878678] Infect Immun. 1995 Jul;63(7):2391-5 [7790048] J Clin Pharmacol. 1995 Oct;35(10):957-66 [8568013] AIDS. 1999 Sep;13 Suppl 1:S49-59 [10546785] Toxicol Sci. 2000 Jun;55(2):335-42 [10828265] J Invest Dermatol. 2000 Jun;114(6):1164-73 [10844561] Ann Intern Med. 2000 Jul 4;133(1):35-9 [10877738] Comp Med. 2000 Feb;50(1):49-55 [10987669] J Immunol. 2000 Nov 15;165(10):5558-65 [11067910] Br J Pharmacol. 2001 May;133(2):295-305 [11350866] AIDS. 2001 Sep 7;15(13):1687-94 [11546944] J Clin Invest. 2001 Nov;108(10):1469-74 [11714738] N Engl J Med. 2002 Mar 14;346(11):811-20 [11893792] MMWR Recomm Rep. 2002 Jun 14;51(RR-8):1-52 [12081007] Mol Pharmacol. 2002 Sep;62(3):628-37 [12181439] MMWR CDC Surveill Summ. 1999 Apr 16;48(2):1-22 [12412613] J Mol Biol. 2003 May 23;329(1):45-57 [12742017] J Immunol. 2003 Jun 15;170(12):5965-72 [12794123] J Immunol. 2003 Aug 1;171(3):1423-30 [12874234] Infect Immun. 2003 Dec;71(12):6808-19 [14638767] Emerg Infect Dis. 2004 Oct;10(10):1713-20 [15504255] Chemotherapy. 1973;18(5):274-84 [4728201] Chemotherapy. 1974;20(6):321-30 [4442290] Antibiot Chemother (1971). 1974;18:148-98 [4463825] Infect Immun. 1997 Dec;65(12):5052-6 [9393795] BMJ. 1998 Apr 25;316(7140):1295-8 [9554902] J Clin Immunol. 1998 May;18(3):235-40 [9624583] Gen Pharmacol. 1998 Oct;31(4):531-8 [9792211] Lancet. 1998 Dec 12;352(9144):1919-22 [9863802] Br J Pharmacol. 1999 Mar;126(6):1393-407 [10217534] Int Immunopharmacol. 2005 Dec;5(13-14):1881-94 [16275623] J Pediatr. 1985 Sep;107(3):352-7 [4032129] Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7 [2430286] J Immunol. 1987 Jun 1;138(11):3720-4 [2953790] N Engl J Med. 1987 Jul 23;317(4):192-7 [3299090] Ann Intern Med. 1987 Oct;107(4):502-5 [3477107] Clin Exp Immunol. 1987 Jun;68(3):479-87 [3652522] Lab Invest. 1988 Mar;58(3):324-31 [3258045] J Clin Invest. 1988 Jun;81(6):1666-8 [2454947] Br J Haematol. 1988 Jul;69(3):299-304 [3261597] Exp Hematol. 1988 Dec;16(11):938-40 [3181343] J Infect Dis. 1988 Nov;158(5):983-90 [3183430] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hexosamines regulate sensitivity of glucose-stimulated insulin secretion in beta-cells. AN - 67616645; 16188910 AB - Hexosamines serve a nutrient-sensing function through enzymatic O-glycosylation of proteins. We previously characterized transgenic (Tg) mice with overexpression of the rate-limiting enzyme in hexosamine production, glutamine:fructose-6-phosphate amidotransferase, in beta-cells. Animals were hyperinsulinemic, resulting in peripheral insulin resistance. Glucose tolerance deteriorated with age, and males developed diabetes. We therefore examined islet function in these mice by perifusion in vitro. Young (2-mo-old) Tg animals had enhanced sensitivity to glucose of insulin secretion. Insulin secretion was maximal at 20 mM and half maximal at 9.9 +/- 0.5 mM glucose in Tg islets compared with maximal at 30 mM and half maximal at 13.5 +/- 0.7 mM glucose in wild type (WT; P < 0.005). Young Tg animals secreted more insulin in response to 20 mM glucose (Tg, 1,254 +/- 311; WT, 425 +/- 231 pg x islet(-1) x 35 min(-1); P < 0.01). Islets from older (8-mo-old) Tg mice became desensitized to glucose, with half-maximal secretion at 16.1 +/- 0.8 mM glucose, compared with 11.8 +/- 0.7 mM in WT (P < 0.05). Older Tg mice secreted less insulin in response to 20 mM glucose (Tg, 2,256 +/- 342; WT, 3,493 +/- 367 pg x islet(-1) x 35 min(-1); P < 0.05). Secretion in response to carbachol was similar in WT and Tg at both ages. Glucose oxidation was blunted in older Tg islets. At 5 mM glucose, islet CO2 production was comparable between Tg and WT. However, WT mice increased islet CO2 production 2.7 +/- 0.4-fold in 20 mM glucose, compared with only 1.4 +/- 0.1-fold in Tg (P < 0.02). Results demonstrate that hexosamines are involved in nutrient sensing for insulin secretion, acting at least in part by modulating glucose oxidation pathways. Prolonged excess hexosamine flux results in glucose desensitization and mimics glucose toxicity. JF - American journal of physiology. Endocrinology and metabolism AU - Cooksey, Robert C AU - Pusuluri, Sumitha AU - Hazel, Mark AU - McClain, Donald A AD - Veterans Administration Medical Center and Division of Endocrinology and Metabolism, University of Utah School of Medicine, 30 N. 2030 East, Salt Lake City, UT 84132, USA. Y1 - 2006/02// PY - 2006 DA - February 2006 SP - E334 EP - E340 VL - 290 IS - 2 SN - 0193-1849, 0193-1849 KW - Hexosamines KW - 0 KW - Insulin KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Mice, Transgenic -- metabolism KW - Animals KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Mice KW - Hexosamines -- metabolism KW - Hexosamines -- genetics KW - Insulin -- biosynthesis KW - Glucose -- metabolism KW - Insulin-Secreting Cells -- metabolism KW - Insulin Resistance -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67616645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Endocrinology+and+metabolism&rft.atitle=Hexosamines+regulate+sensitivity+of+glucose-stimulated+insulin+secretion+in+beta-cells.&rft.au=Cooksey%2C+Robert+C%3BPusuluri%2C+Sumitha%3BHazel%2C+Mark%3BMcClain%2C+Donald+A&rft.aulast=Cooksey&rft.aufirst=Robert&rft.date=2006-02-01&rft.volume=290&rft.issue=2&rft.spage=E334&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Endocrinology+and+metabolism&rft.issn=01931849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-22 N1 - Date created - 2006-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interdisciplinary Care Planning and the Written Care Plan in Nursing Homes: A Critical Review AN - 61403918; 200704602 AB - Purpose: This article is a critical review of the history, research evidence, & state-of-the-art technology in interdisciplinary care planning & the written plan of care in American nursing homes. Design and Methods: We reviewed educational & empirical literature. Results: Interdisciplinary care planning & the written care plan are mandated processes that are imbedded in the regulatory fabric & routines of the American nursing home. These processes evolved from the discipline of nursing, where care planning has had a long & controversial history. Implications: Practice implications are provided. References. Adapted from the source document. JF - The Gerontologist AU - Dellefield, Mary Ellen AD - VA San Diego Medical Center, CA mary.dellefield@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 128 EP - 133 PB - Gerontological Society of America, Washington DC VL - 46 IS - 1 SN - 0016-9013, 0016-9013 KW - Care plan, Clinical documentation, Interdisciplinary practice, Nursing home, Coordinating care KW - Documentation KW - Coordination KW - Planning KW - United States of America KW - Interdisciplinary Approach KW - Nursing Homes KW - Health Care Services KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61403918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=Interdisciplinary+Care+Planning+and+the+Written+Care+Plan+in+Nursing+Homes%3A+A+Critical+Review&rft.au=Dellefield%2C+Mary+Ellen&rft.aulast=Dellefield&rft.aufirst=Mary&rft.date=2006-02-01&rft.volume=46&rft.issue=1&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-11-01 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Nursing Homes; Health Care Services; Planning; Documentation; Interdisciplinary Approach; Coordination; United States of America ER - TY - JOUR T1 - Rasch Modeling of Revised Token Test Performance: Validity and Sensitivity to Change AN - 57122208; 200702393 AB - The purpose of this research was to examine the validity of the 55-item Revised Token Test (RTT) & to compare traditional & Rasch-based scores in their ability to detect group differences & change over time. The 55-item RTT was administered to 108 left- & right-hemisphere stroke survivors, & the data were submitted to Rasch analysis. Traditional & Rasch-based scores for a subsample of 60 stroke survivors were submitted to analyses of variance with group (left hemisphere with aphasia vs. right hemisphere) & time post onset (3 vs. 6 months post onset) as factors. The 2 scoring methods were compared using an index of relative precision. Forty-eight items demonstrated acceptable model fit. Misfitting items came primarily from Subtest IX. The Rasch model accounted for 71% of the variance in the responses to the remaining items. Intersubtest patterns of item difficulty were well predicted by item content, but unexpected within-subtest differences were found. Both traditional & Rasch person scores demonstrated significant group differences, but only the latter demonstrated statistically significant change over time. Analysis of relative precision, however, failed to confirm a significant difference between the 2 methods. The findings generally support the RTT's validity, but a minority of items appears to respond to a different construct. Also, within-subtest differences in item difficulty suggest the need for further examination of variability in impaired language performance. Finally, the results suggest an equivocal advantage for Rasch scores in detecting change over time. Tables, Figures, References. Adapted from the source document. JF - Journal of Speech, Language, and Hearing Research AU - Hula, William AU - Doyle, Patrick J AU - McNeil, Malcolm R AU - Mikolic, Joseph M AD - VA Pittsburgh Healthcare System, PA william.hula@med.va.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - 27 EP - 46 PB - American Speech-Language-Hearing Association, Rockville MD VL - 49 IS - 1 SN - 1092-4388, 1092-4388 KW - assessment, aphasia, auditory comprehension, spoken language comprehension assessment, standardized assessment KW - Assessment KW - Rasch model KW - Language skills KW - Aphasia KW - Strokes KW - Validity studies KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57122208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=Rasch+Modeling+of+Revised+Token+Test+Performance%3A+Validity+and+Sensitivity+to+Change&rft.au=Hula%2C+William%3BDoyle%2C+Patrick+J%3BMcNeil%2C+Malcolm+R%3BMikolic%2C+Joseph+M&rft.aulast=Hula&rft.aufirst=William&rft.date=2006-02-01&rft.volume=49&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/10.1044%2F1092-4388%282006%2F003%29 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-02-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Validity studies; Rasch model; Aphasia; Strokes; Language skills; Assessment DO - http://dx.doi.org/10.1044/1092-4388(2006/003) ER - TY - JOUR T1 - Anti-Interleukin-15 Prevents Arthritis in Borrelia-Vaccinated and -Infected Mice AN - 19940783; 6718591 AB - We showed previously that interleukin-17 (IL-17) plays a significant role in the induction of arthritis associated with Borrelia vaccination and challenge. Little information, however, is available about the chain of immunologic events that leads to the release of IL-17. The production of IL-17 has been linked to stimulation of memory cells by IL-15. Therefore, we hypothesized that IL-15 is involved in the induction of arthritis associated with Borrelia vaccination and infection of mice. Here we present evidence that treatment of Borrelia-vaccinated and -infected mice with anti-IL-15 antibody prevents swelling of the hind paws. More importantly, both anti-IL-15 antibody- and recombinant IL-15 receptor alpha-treated Borrelia-vaccinated and -infected mice were free of major histopathologic indications of arthritis, including hyperplasia, hypertrophy, and vilus formation of the synovium. Similarly, the synovial space and perisynovium were free of inflammatory cells. By contrast, the synovium of nontreated Borrelia-vaccinated and -infected mice had overt hyperplasia, hypertrophy, and vilus formation. Moreover, the synovial space and perisynovium were infiltrated with neutrophils, macrophages, and lymphocytes. Finally, we show that recombinant IL-15 stimulates the release of IL-17 from lymph node cells obtained near the arthritic site. These results suggest that IL-15 plays a major role in orchestrating IL-17 induction of arthritis associated with Borrelia-vaccinated and -infected mice. JF - Clinical and Vaccine Immunology AU - Amlong, Corey A AU - Nardelli, Dean T AU - Peterson, Sara Heil AU - Warner, Thomas F AU - Callister, Steven M AU - Schell, Ronald F AD - Wisconsin State Laboratory of Hygiene. Department of Bacteriology. Department of Comparative Biomedical Sciences. Department of Medical Microbiology and Immunology, University of Wisconsin. Department of Pathology, Veterans Administration Hospital, Madison. Microbiology Research Laboratory and Section of Infectious Diseases, Gundersen Lutheran Medical Center, La Crosse, Wisconsin Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 289 EP - 296 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 13 IS - 2 SN - 1556-6811, 1556-6811 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Interleukin 15 receptors KW - Synovium KW - Memory cells KW - Leukocytes (neutrophilic) KW - Lymphocytes KW - Infection KW - Vaccination KW - Lymph nodes KW - Inflammation KW - Antibodies KW - Hypertrophy KW - Hyperplasia KW - Interleukin 15 KW - Arthritis KW - Interleukin 17 KW - Borrelia KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19940783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Anti-Interleukin-15+Prevents+Arthritis+in+Borrelia-Vaccinated+and+-Infected+Mice&rft.au=Amlong%2C+Corey+A%3BNardelli%2C+Dean+T%3BPeterson%2C+Sara+Heil%3BWarner%2C+Thomas+F%3BCallister%2C+Steven+M%3BSchell%2C+Ronald+F&rft.aulast=Amlong&rft.aufirst=Corey&rft.date=2006-02-01&rft.volume=13&rft.issue=2&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; Interleukin 15 receptors; Synovium; Leukocytes (neutrophilic); Memory cells; Lymphocytes; Infection; Vaccination; Lymph nodes; Inflammation; Hyperplasia; Hypertrophy; Antibodies; Interleukin 15; Interleukin 17; Arthritis; Borrelia ER - TY - JOUR T1 - Toll-Like Receptor 4 Protects against Lethal Leptospira interrogans Serovar Icterohaemorrhagiae Infection and Contributes to In Vivo Control of Leptospiral Burden AN - 17473333; 6660899 AB - The roles of innate immune responses in protection from or pathogenesis of severe leptospirosis remain unclear. We examined the role of Toll-like receptors (TLRs) in mouse infection and macrophage responses to LEPTOSPIRA: C3H/HeJ mice (TLR4 deficient) and C3H/HeJ-SCID mice, but not C3H/OuJ mice (TLR4 intact), died after intraperitoneal infection with Leptospira interrogans serovar Icterohaemorrhagiae. Death in both C3H/HeJ mouse strains was associated with jaundice and pulmonary hemorrhage, similar to the patient from whom the isolate was obtained. In chronic sublethal infection, TLR4-deficient mice harbored more leptospires in liver, lung, and kidney than control mice. Heat-killed Leptospira stimulated macrophages to secrete proinflammatory cytokines, tumor necrosis factor alpha, interleukin-6, and macrophage inflammatory protein 2 not inhibited by polymyxin B, suggesting that leptospiral lipopolysaccharide (LPS) did not drive these responses. Anti-TLR4 and anti-MD-2 but not anti-CD14 monoclonal antibodies inhibited cytokine production. Peritoneal macrophages from CD14 super(-/-) and TLR2 super(-/-) mice exhibited no defect in cytokine responses to Leptospira compared to controls. Macrophages from C3H/HeJ, TLR4 super(-/-), and MyD88 super(-/-) mice secreted far-lower levels of cytokines than wild-type macrophages in response to LEPTOSPIRA: TLR4 plays a crucial role in protection from acute lethal infection and control of leptospiral burden during sublethal chronic infection. Cytokine responses in macrophages correlated with leptospiral clearance. These TLR4-dependent but CD14/TLR2-independent responses are likely mediated by a leptospiral ligand(s) other than LPS. JF - Infection and Immunity AU - Viriyakosol, Suganya AU - Matthias, Michael A AU - Swancutt, Mark A AU - Kirkland, Theo N AU - Vinetz, Joseph M AD - Division of Infectious Diseases, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0640. Veterans Administration San Diego Healthcare System and Department of Pathology, University of California, San Diego, 3350 La Jolla Village Drive, La Jolla, California 92161 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 887 EP - 895 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 2 SN - 0019-9567, 0019-9567 KW - mice KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - macrophage inflammatory protein 2 KW - Leptospirosis KW - polymyxin B KW - Hemorrhage KW - Leptospira interrogans KW - Lung KW - Kidney KW - Lipopolysaccharides KW - Cytokines KW - Tumor necrosis factor- alpha KW - TLR4 protein KW - Toll-like receptors KW - F 06106:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17473333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Toll-Like+Receptor+4+Protects+against+Lethal+Leptospira+interrogans+Serovar+Icterohaemorrhagiae+Infection+and+Contributes+to+In+Vivo+Control+of+Leptospiral+Burden&rft.au=Viriyakosol%2C+Suganya%3BMatthias%2C+Michael+A%3BSwancutt%2C+Mark+A%3BKirkland%2C+Theo+N%3BVinetz%2C+Joseph+M&rft.aulast=Viriyakosol&rft.aufirst=Suganya&rft.date=2006-02-01&rft.volume=74&rft.issue=2&rft.spage=887&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; macrophage inflammatory protein 2; Leptospirosis; Lung; Kidney; Cytokines; Lipopolysaccharides; Tumor necrosis factor- alpha; polymyxin B; Hemorrhage; TLR4 protein; Toll-like receptors; Leptospira interrogans ER - TY - JOUR T1 - Pathogenesis of B-Cell Superantigen-Induced Immune Complex-Mediated Inflammation AN - 17465727; 6660857 AB - Staphylococcal protein A (SpA) is representative of a new class of antigens, the B-cell superantigens (SAgs). These antigens bind to the Fab regions of immunoglobulin molecules outside their complementarity-determining regions. SpA, the best-studied B-cell SAg, reacts with the Fabs of most V sub(H)3 super(+) immunoglobulins, which are expressed on 30 to 60% of human peripheral B cells. Therefore, B-cell SAgs like SpA have great potential to elicit inflammatory responses in vivo. We previously reported that the interaction of SpA with V sub(H)3 super(+) immunoglobulin molecules leads to activation of the complement cascade and produces a histologic pattern of inflammation in the skin of a rabbit indicative of immune complex injury. To elucidate the cellular and molecular events contributing to this type of unconventional immune complex-mediated inflammation, we established a mouse peritoneal Arthus reaction model. Mice treated intravenously with human polyclonal immunoglobulin G (IgG), followed by intraperitoneal injection of SpA, showed neutrophil influx into the peritoneal cavity with peak numbers appearing at 8 h. This inflammatory reaction was dependent on the interaction of SpA with V sub(H)3 super(+) IgG. Mast cells, Fc gamma RIII, complement components, and tumor necrosis factor alpha play obligatory roles, and the reaction is associated with the local release of the CXC chemokines macrophage inflammatory protein 2 and KC. The data provide further compelling evidence for the induction of immune complex-mediated injury by a B-cell SAg and highlight important factors contributing to the pathogenesis of this novel type of inflammatory reaction. JF - Infection and Immunity AU - Anderson, Amy L AU - Sporici, Romeo AU - Lambris, John AU - LaRosa, David AU - Levinson, Arnold I AD - Allergy and Immunology Section, Philadelphia Veterans' Administration Medical Center. Department of Laboratory Medicine and Pathology. Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 1196 EP - 1203 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 2 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Arthus reaction KW - macrophage inflammatory protein 2 KW - CXC chemokines KW - Lymphocytes B KW - Antigen-antibody complexes KW - Leukocytes (neutrophilic) KW - Mast cells KW - Inflammation KW - Complement activation KW - Immunoglobulin G KW - complementarity-determining region KW - Tumor necrosis factor- alpha KW - F 06106:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17465727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Pathogenesis+of+B-Cell+Superantigen-Induced+Immune+Complex-Mediated+Inflammation&rft.au=Anderson%2C+Amy+L%3BSporici%2C+Romeo%3BLambris%2C+John%3BLaRosa%2C+David%3BLevinson%2C+Arnold+I&rft.aulast=Anderson&rft.aufirst=Amy&rft.date=2006-02-01&rft.volume=74&rft.issue=2&rft.spage=1196&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Arthus reaction; CXC chemokines; macrophage inflammatory protein 2; Lymphocytes B; Antigen-antibody complexes; Complement activation; Leukocytes (neutrophilic); Immunoglobulin G; Mast cells; complementarity-determining region; Tumor necrosis factor- alpha; Inflammation ER - TY - JOUR T1 - Respiratory Syncytial Virus Induces TLR3 Protein and Protein Kinase R, Leading to Increased Double-Stranded RNA Responsiveness in Airway Epithelial Cells AN - 17458195; 6662059 AB - Respiratory syncytial virus (RSV) preferentially infects airway epithelial cells, causing bronchiolitis, upper respiratory infections, asthma exacerbations, chronic obstructive pulmonary disease exacerbations, and pneumonia in immunocompromised hosts. A replication intermediate of RSV is dsRNA. This is an important ligand for both the innate immune receptor, TLR3, and protein kinase R (PKR). One known effect of RSV infection is the increased responsiveness of airway epithelial cells to subsequent bacterial ligands (i.e., LPS). In this study, we examined a possible role for RSV infection in increasing amounts and responsiveness of another TLR, TLR3. These studies demonstrate that RSV infection of A549 and human tracheobronchial epithelial cells increases the amounts of TLR3 and PKR in a time-dependent manner. This leads to increased NF- Kappa B activity and production of the inflammatory cytokine IL-8 following a later exposure to dsRNA. Importantly, TLR3 was not detected on the cell surface at baseline but was detected on the cell surface after RSV infection. The data demonstrate that RSV, via an effect on TLR3 and PKR, sensitizes airway epithelial cells to subsequent dsRNA exposure. These findings are consistent with the hypothesis that RSV infection sensitizes the airway epithelium to subsequent viral and bacterial exposures by up-regulating TLRs and increasing their membrane localization. JF - Journal of Immunology AU - Groskreutz, Dayna J AU - Monick, Martha M AU - Powers, Linda S AU - Yarovinsky, Timur O AU - Look, Dwight C AU - Hunninghake, Gary W AD - Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Roy J. and Lucille A. Carver College of Medicine and Veterans Administration Medical Center, Iowa City, IA 52242 Y1 - 2006/02/01/ PY - 2006 DA - 2006 Feb 01 SP - 1733 EP - 1740 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 176 IS - 3 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Cell surface KW - Epithelial cells KW - eIF-2 kinase KW - Data processing KW - Replication KW - Double-stranded RNA KW - Asthma KW - Infection KW - Interleukin 8 KW - NF- Kappa B protein KW - Chronic obstructive pulmonary disease KW - Inflammation KW - Respiratory syncytial virus KW - TLR3 protein KW - protein kinase R KW - Immunocompromised hosts KW - Chronic infection KW - Lipopolysaccharides KW - Epithelium KW - Pneumonia KW - Toll-like receptors KW - Bronchopneumonia KW - Respiratory tract KW - V 22099:Immune response & immune mechanisms KW - F 06302:Clinical: Immediate KW - J 02350:Immunology KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17458195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Respiratory+Syncytial+Virus+Induces+TLR3+Protein+and+Protein+Kinase+R%2C+Leading+to+Increased+Double-Stranded+RNA+Responsiveness+in+Airway+Epithelial+Cells&rft.au=Groskreutz%2C+Dayna+J%3BMonick%2C+Martha+M%3BPowers%2C+Linda+S%3BYarovinsky%2C+Timur+O%3BLook%2C+Dwight+C%3BHunninghake%2C+Gary+W&rft.aulast=Groskreutz&rft.aufirst=Dayna&rft.date=2006-02-01&rft.volume=176&rft.issue=3&rft.spage=1733&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Cell surface; Data processing; eIF-2 kinase; Replication; Double-stranded RNA; Asthma; Infection; Interleukin 8; Inflammation; Chronic obstructive pulmonary disease; NF- Kappa B protein; protein kinase R; TLR3 protein; Immunocompromised hosts; Chronic infection; Lipopolysaccharides; Epithelium; Bronchopneumonia; Toll-like receptors; Pneumonia; Respiratory tract; Respiratory syncytial virus ER - TY - JOUR T1 - Lower Extremity Physical Performance and Use of Compensatory Strategies for Mobility AN - 17155027; 6764745 AB - OBJECTIVES: To compare measured lower extremity physical performance in the clinic with the methods used to carry out mobility tasks at home and to identify key factors influencing day-to-day task performance. DESIGN: Cross-sectional analysis of the Women's Health and Aging Study I. SETTING: Community-dwelling female residents of Baltimore, Maryland. PARTICIPANTS: One thousand two cognitively intact women aged 65 and older with moderate to severe physical limitations. MEASUREMENTS: Compensatory strategies reportedly used for mobility in the home, distinguishing between use of no compensatory strategies, behavioral changes only, durable medical equipment (DME) with or without behavioral change, and human help; measured lower extremity (LE) physical performance (gait speed, timed chair stands, balance). RESULTS: There was a statistically significant difference in LE physical performance between women using the four types of compensatory strategy (P<.001). Women who used DME for mobility in the home had worse performance than those using human help who in turn had worse performance than those with behavioral changes only; women reporting no compensatory strategies for in-home mobility performed best. Sequential multivariate logistic regressions identified several factors other than LE physical performance that were associated with use of specific compensatory strategies. Medical conditions, education, and environmental barriers influenced whether compensatory strategies were used at all, whereas income, contact with health providers, and availability of help in the home influenced the type of compensatory strategy. CONCLUSION: Physical abilities are an important factor influencing use of compensatory strategies for mobility, but several other factors also influence the ways that women adapt to mobility limitations. JF - Journal of the American Geriatrics Society AU - Hoenig, Helen AU - Ganesh, Shanti Portia AU - Taylor, Donald H AU - Pieper, Carl AU - Guralnik, Jack AU - Fried, Linda P AD - Helen Hoenig, Rehabilitation Service, 508 Fulton Street, Durham, NC 27705, helen.hoenig@med.va.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 262 EP - 269 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 54 IS - 2 SN - 0002-8614, 0002-8614 KW - Physical Education Index KW - disability measurement KW - mobility KW - assistive technology KW - history of medicine KW - activities of daily living KW - Measurement KW - Statistics KW - Home KW - Equipment KW - Barriers KW - Women KW - Strategy KW - Gerontology KW - Health KW - Legs KW - Movement KW - Education KW - Speed KW - Analysis KW - Geriatrics KW - Performance KW - Gait KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17155027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Lower+Extremity+Physical+Performance+and+Use+of+Compensatory+Strategies+for+Mobility&rft.au=Hoenig%2C+Helen%3BGanesh%2C+Shanti+Portia%3BTaylor%2C+Donald+H%3BPieper%2C+Carl%3BGuralnik%2C+Jack%3BFried%2C+Linda+P&rft.aulast=Hoenig&rft.aufirst=Helen&rft.date=2006-02-01&rft.volume=54&rft.issue=2&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2005.00588.x LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - SuppNotes - Figures, 2; tables, 4; references, 31. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Measurement; Barriers; Equipment; Home; Statistics; Strategy; Women; Gerontology; Legs; Health; Movement; Speed; Education; Analysis; Geriatrics; Performance; Gait DO - http://dx.doi.org/10.1111/j.1532-5415.2005.00588.x ER - TY - JOUR T1 - Toll-like receptors, inflammation and cancer AN - 17095567; 6722001 AB - Toll-like receptors (TLRs) play a crucial role in the host defense against invading microorganisms by recognizing pathogen-associated molecular patterns (PAMPs). The anti-cancer effects of a number of microbial components, that have been used as adjuvants for the immunotherapy of cancers, are mediated through TLR signaling. However, cancer immunotherapy is not always successful because of the immunosuppression associated with cancer progression. Recently, a number of endogenous molecules have been reported to be ligands of TLRs. It has been suggested that the release of these putative endogenous ligands of TLRs during cancer progression may cause chronic inflammation leading to the recruitment of myeloid suppressor cells and down-regulation of T-cell and natural killer (NK) cell receptor zeta ( direct sum ) chain resulting in T and NK cell dysfunction. However, the reported putative endogenous TLR ligands may have been contaminated with PAMPs. Further studies are necessary to define the existence of endogenous TLR ligands and their potential contribution to the immunosuppression in cancer. JF - Seminars in Cancer Biology AU - Tsan, M F AD - Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA, min-fu.tsan2@med.va.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 32 EP - 37 VL - 16 IS - 1 SN - 1044-579X, 1044-579X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Immunotherapy KW - Natural killer cells KW - Lymphocytes T KW - Microorganisms KW - Suppressor cells KW - Adjuvants KW - Toll-like receptors KW - Cancer KW - Inflammation KW - Immunosuppression KW - Signal transduction KW - A 01490:Miscellaneous KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17095567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Cancer+Biology&rft.atitle=Toll-like+receptors%2C+inflammation+and+cancer&rft.au=Tsan%2C+M+F&rft.aulast=Tsan&rft.aufirst=M&rft.date=2006-02-01&rft.volume=16&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Cancer+Biology&rft.issn=1044579X&rft_id=info:doi/10.1016%2Fj.semcancer.2005.07.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Immunotherapy; Microorganisms; Lymphocytes T; Natural killer cells; Suppressor cells; Adjuvants; Cancer; Toll-like receptors; Signal transduction; Immunosuppression; Inflammation DO - http://dx.doi.org/10.1016/j.semcancer.2005.07.004 ER - TY - JOUR T1 - Hypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the Research on Adverse Drug Events and Reports (RADAR) project. AN - 67600390; 16386683 AB - We undertook the review of all available cases of hypersensitivity reactions after placement of a drug-eluting stent (DES) and classified potential causes. Six months after the approval of the first DES, the Food and Drug Administration (FDA) reported 50 hypersensitivity reactions after stent placement but later concluded these were due to concomitantly prescribed medications such as clopidogrel. Nevertheless, the FDA continued to receive reports of hypersensitivity. Reports available from April 2003 through December 2004 for hypersensitivity-like reactions associated with the sirolimus-eluting stent (CYPHER, Cordis Corp., Miami Lakes, Florida) and paclitaxel-eluting stent (TAXUS, Boston Scientific Corp., Natick, Massachusetts) were reviewed. Sources of reports included the FDA's adverse-device-event database, the published literature, and investigators from the Research on Adverse Drug/Device events And Reports (RADAR) project. Causality was assessed using standardized World Health Organization criteria. Of 5,783 reports identified for the DES in the FDA database, 262 unique events included hypersensitivity symptoms. Of these reports, 2 were certainly and 39 unlikely caused by clopidogrel and 1 was certainly, 9 probably, and 13 unlikely caused by the DES. From all sources, we identified 17 distinct cases that were probably or certainly caused by the stent, of which 9 had symptoms that lasted longer than four weeks. Four autopsies confirmed intrastent eosinophilic inflammation, thrombosis, and lack of intimal healing. The FDA reports and autopsy findings suggest that DES may be a cause of systemic and intrastent hypersensitivity reactions that, in some cases, have been associated with late thrombosis and death. JF - Journal of the American College of Cardiology AU - Nebeker, Jonathan R AU - Virmani, Renu AU - Bennett, Charles L AU - Hoffman, Jennifer M AU - Samore, Matthew H AU - Alvarez, Jorge AU - Davidson, Charles J AU - McKoy, June M AU - Raisch, Dennis W AU - Whisenant, Brian K AU - Yarnold, Paul R AU - Belknap, Steven M AU - West, Dennis P AU - Gage, Jonathan E AU - Morse, Richard E AU - Gligoric, Gordana AU - Davidson, Laura AU - Feldman, Marc D AD - Veterans Administration Salt Lake City, Salt Lake City, Utah, USA. Jonathan.Nebeker@hsc.utah.edu Y1 - 2006/01/03/ PY - 2006 DA - 2006 Jan 03 SP - 175 EP - 181 VL - 47 IS - 1 KW - Paclitaxel KW - P88XT4IS4D KW - Sirolimus KW - W36ZG6FT64 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Sirolimus -- adverse effects KW - Paclitaxel -- adverse effects KW - Coronary Vessels KW - Drug Hypersensitivity -- etiology KW - Stents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67600390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Hypersensitivity+cases+associated+with+drug-eluting+coronary+stents%3A+a+review+of+available+cases+from+the+Research+on+Adverse+Drug+Events+and+Reports+%28RADAR%29+project.&rft.au=Nebeker%2C+Jonathan+R%3BVirmani%2C+Renu%3BBennett%2C+Charles+L%3BHoffman%2C+Jennifer+M%3BSamore%2C+Matthew+H%3BAlvarez%2C+Jorge%3BDavidson%2C+Charles+J%3BMcKoy%2C+June+M%3BRaisch%2C+Dennis+W%3BWhisenant%2C+Brian+K%3BYarnold%2C+Paul+R%3BBelknap%2C+Steven+M%3BWest%2C+Dennis+P%3BGage%2C+Jonathan+E%3BMorse%2C+Richard+E%3BGligoric%2C+Gordana%3BDavidson%2C+Laura%3BFeldman%2C+Marc+D&rft.aulast=Nebeker&rft.aufirst=Jonathan&rft.date=2006-01-03&rft.volume=47&rft.issue=1&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=1558-3597&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-27 N1 - Date created - 2006-01-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Am Coll Cardiol. 2006 Aug 1;48(3):592-3; author reply 593-4 [16875994] J Am Coll Cardiol. 2006 Jan 3;47(1):182-3 [16386684] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Patient-Reported Outcome Measures: Use in Evaluation of Treatment for Aphasia AN - 85665884; 200701885 AB - Properties of patient-reported outcome instruments for the evaluation of therapy are reviewed, & three scales designed especially for use by aphasic patients are described in summary form. References. J. Hitchcock JF - Journal of Medical Speech-Language Pathology AU - Ross, Katherine B AD - Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ katherine.ross2@va.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - ix EP - xi VL - 14 IS - 3 SN - 1065-1438, 1065-1438 KW - Diagnosis (18540) KW - Language Therapy (44400) KW - Aphasia (03400) KW - Self Evaluation (76550) KW - Measures (Instruments) (52300) KW - Speech Therapy (83200) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85665884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Speech-Language+Pathology&rft.atitle=Patient-Reported+Outcome+Measures%3A+Use+in+Evaluation+of+Treatment+for+Aphasia&rft.au=Ross%2C+Katherine+B&rft.aulast=Ross&rft.aufirst=Katherine&rft.date=2006-01-01&rft.volume=14&rft.issue=3&rft.spage=ix&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Speech-Language+Pathology&rft.issn=10651438&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2007-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSLPEP N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Speech Therapy (83200); Language Therapy (44400); Self Evaluation (76550); Measures (Instruments) (52300); Diagnosis (18540) ER - TY - JOUR T1 - A 5-year prospective study of diabetes and hearing loss in a veteran population. AN - 85400973; pmid-16371845 AB - Veterans with diabetes will have significantly greater hearing loss than nondiabetic veterans.The association between diabetes and hearing loss remains unclear despite the volume of research that has been devoted to the question. Often, differences in hearing thresholds between diabetic and nondiabetic patients are confounded by age and noise exposure.In this 5-year prospective study, 342 diabetic veterans and 352 nondiabetic veterans from the Portland VA Medical Center in Oregon were tested on a variety of audiometric measures, including pure-tone thresholds.Age and noise exposure were accounted for in the analyses. There was a trend toward greater hearing loss in diabetic patients 60 years of age and younger across the frequency range. These differences were statistically significant only in the highest frequencies tested (10, 12.5, 14, and 16 kHz). The effects of both diabetes and noise exposure on high-frequency hearing thresholds were dependent on age. For patients older than 60 years, the mean thresholds were not significantly different.These results suggest that diabetic patients 60 years old or younger may show early high-frequency hearing loss similar to early presbycusis. After age 60, difference in hearing loss between diabetic and nondiabetic patients was reduced. JF - Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology AU - Vaughan, Nancy AU - James, Kenneth AU - McDermott, Daniel AU - Griest, Susan AU - Fausti, Stephen AD - National Center for Rehabilitative Auditory Research, Portland Veterans Affairs Medical Center and, Portland, Oregon 97239, USA. Nancy.Vaughan@med.va.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 37 EP - 43 VL - 27 IS - 1 SN - 1531-7129, 1531-7129 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Age Factors KW - Aged KW - Aged, 80 and over KW - Audiometry, Pure-Tone KW - *Auditory Threshold KW - Diabetes Complications: physiopathology KW - Female KW - Hearing Loss, Sensorineural: diagnosis KW - *Hearing Loss, Sensorineural: etiology KW - Humans KW - Male KW - Middle Aged KW - Noise: adverse effects KW - Prospective Studies KW - *Veterans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85400973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otology+%26+neurotology+%3A+official+publication+of+the+American+Otological+Society%2C+American+Neurotology+Society+%5Band%5D+European+Academy+of+Otology+and+Neurotology&rft.atitle=A+5-year+prospective+study+of+diabetes+and+hearing+loss+in+a+veteran+population.&rft.au=Vaughan%2C+Nancy%3BJames%2C+Kenneth%3BMcDermott%2C+Daniel%3BGriest%2C+Susan%3BFausti%2C+Stephen&rft.aulast=Vaughan&rft.aufirst=Nancy&rft.date=2006-01-01&rft.volume=27&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Otology+%26+neurotology+%3A+official+publication+of+the+American+Otological+Society%2C+American+Neurotology+Society+%5Band%5D+European+Academy+of+Otology+and+Neurotology&rft.issn=15317129&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Swallowing lateralization: the effects of modified dual-task interference. AN - 85397759; pmid-16544089 AB - A modified dual-task paradigm was designed to learn whether swallowing functions are selectively mediated by the left or right hemisphere. Healthy right-handed men (N = 38) were studied using videofluoroscopy to examine continuous straw drinking at baseline and with three interference conditions (silent word repetition, line orientation, finger tapping). Results indicate that activation of both right and left hemispheres can interfere with some swallowing behaviors. Findings suggest possibly different roles of the two hemispheres in the mediation of swallowing and support the notion that specific components of swallowing may be preferentially mediated by the left versus the right hemisphere. JF - Dysphagia AU - Daniels, Stephanie K AU - Corey, David M AU - Fraychinaud, April AU - DePolo, Asha AU - Foundas, Anne L AD - Research Service, Department of Veterans Affairs Medical Center, New Orleans, Louisiana 70112-1262, USA. stephanie.daniels@med.va.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 21 EP - 27 VL - 21 IS - 1 SN - 0179-051X, 0179-051X KW - Index Medicus KW - National Library of Medicine KW - Analysis of Variance KW - *Deglutition: physiology KW - Deglutition Disorders: physiopathology KW - Dominance, Cerebral: physiology KW - Fluoroscopy KW - *Functional Laterality: physiology KW - Humans KW - Male KW - Middle Aged KW - Positron-Emission Tomography KW - Task Performance and Analysis KW - Video Recording UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85397759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dysphagia&rft.atitle=Swallowing+lateralization%3A+the+effects+of+modified+dual-task+interference.&rft.au=Daniels%2C+Stephanie+K%3BCorey%2C+David+M%3BFraychinaud%2C+April%3BDePolo%2C+Asha%3BFoundas%2C+Anne+L&rft.aulast=Daniels&rft.aufirst=Stephanie&rft.date=2006-01-01&rft.volume=21&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Dysphagia&rft.issn=0179051X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Lifetime histories of trauma among pathological gamblers. AN - 70726409; 16449091 AB - This study extends the work completed with pathological gamblers and substance abusers, looking at associations between a history of trauma and comorbid substance dependence, impulsivity, measures of problem severity, and personality variables. We studied 111 patients admitted to the gambling treatment program at the Brecksville VA Medical Center and found that 64% of gamblers reported a history of emotional trauma; 40.5%, physical trauma; and 24.3%, sexual trauma. Most of this trauma occurred in childhood. A history of trauma was associated with a greater relative frequency of suicide attempts and drug and alcohol dependence, more severe scores in measures of psychiatric distress, and limited effects on personality functioning. JF - The American journal on addictions AU - Kausch, Otto AU - Rugle, Loreen AU - Rowland, Douglas Y AD - Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Otto.Kausch@med.va.gov PY - 2006 SP - 35 EP - 43 VL - 15 IS - 1 SN - 1055-0496, 1055-0496 KW - Index Medicus KW - Child Abuse -- psychology KW - Suicide, Attempted -- psychology KW - Child Abuse -- statistics & numerical data KW - Humans KW - Aged KW - Personality Inventory KW - Child KW - Impulsive Behavior -- epidemiology KW - Comorbidity KW - Cross-Sectional Studies KW - Suicide, Attempted -- statistics & numerical data KW - Risk Factors KW - Impulsive Behavior -- psychology KW - Adult KW - Middle Aged KW - Statistics as Topic KW - Male KW - Female KW - Hospitals, Veterans KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Gambling -- psychology KW - Veterans -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Life Change Events KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Veterans -- psychology KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70726409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Lifetime+histories+of+trauma+among+pathological+gamblers.&rft.au=Kausch%2C+Otto%3BRugle%2C+Loreen%3BRowland%2C+Douglas+Y&rft.aulast=Kausch&rft.aufirst=Otto&rft.date=2006-01-01&rft.volume=15&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-09 N1 - Date created - 2006-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of two versions of the clinical institute withdrawal assessment for alcohol: the CIWA-Ar and CIWA-AD. AN - 70713765; 16449097 AB - Scores from two versions of the Clinical Institute Withdrawal Assessment for Alcohol, the CIWA-Ar and CIWA-AD, were compared in 135 alcohol detoxification episodes. The paired mean score for withdrawal severity was statistically higher with the CIWA-AD (p < 0.001), but the mean difference of 0.45 (95% CI: 0.38-0.53, t = 11.74) is not likely to be clinically significant. The difference in the total score between the two scales was 1 point or less 82.6% of the time, and nearly all (97.7%) of the CIWA-AD scores were within 3 points of the paired CIWA-Ar score (range - 6 to + 6). JF - The American journal on addictions AU - Reoux, Joseph P AU - Oreskovich, Michael R AD - VA Puget Sound Health Care System, Seattle, Washington 98108, USA. joe.reoux@med.va.gov PY - 2006 SP - 85 EP - 93 VL - 15 IS - 1 SN - 1055-0496, 1055-0496 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Washington KW - Prospective Studies KW - Substance Abuse Treatment Centers KW - Reproducibility of Results KW - Patient Admission KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Ethanol -- adverse effects KW - Substance Withdrawal Syndrome -- diagnosis KW - Veterans -- psychology KW - Neurologic Examination KW - Diagnostic and Statistical Manual of Mental Disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70713765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=A+comparison+of+two+versions+of+the+clinical+institute+withdrawal+assessment+for+alcohol%3A+the+CIWA-Ar+and+CIWA-AD.&rft.au=Reoux%2C+Joseph+P%3BOreskovich%2C+Michael+R&rft.aulast=Reoux&rft.aufirst=Joseph&rft.date=2006-01-01&rft.volume=15&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-09 N1 - Date created - 2006-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oral ddAVP for nighttime urinary incontinence in characterized nursing home residents: a pilot study. AN - 70683082; 16413428 AB - To (1) identify abnormalities in arginine vasopressin (AVP, a water-conserving hormone) secretion and release in nursing home (NH) residents with nighttime urinary incontinence (UI); and (2) perform a pilot test of desmopressin acetate (ddAVP, a synthetic analog of the naturally occurring hormone) replacement in these residents. Diagnostic evaluation and open-label treatment trial. Two community nursing homes in a metropolitan area. Male and female NH residents 65 years of age and older with nighttime UI. Characterizations of AVP status followed by a 7-day open-label trial of oral ddAVP (either 0.1 mg or 0.2 mg). Water deprivation test results, AVP levels, voided volumes, number of voids, incontinent episodes, number of nighttime checks found wet (out of 6 total checks per night). All participants had measurable AVP levels of 2.0 pg/mL or higher. Six of 10 individuals had an abnormal water deprivation test. Two of 4 participants on 0.2 mg of ddAVP and 2 of 6 participants on 0.1 mg had a 200 mL or more mean reduction in nighttime urine volume. Both ddAVP dosages yielded a mean reduction of 0.7 fewer nighttime wet checks found wet. One participant in each group developed hyponatremia (1 of 6 on 0.1 mg and 1 of 4 on 0.2 mg). Hyponatremia resolved with discontinuation of the drug. Both 0.1 mg and 0.2 mg of ddAVP given to carefully screened NH residents for 7 days produced a modest average reduction in nighttime urine volume and number of nighttime incontinent episodes that is likely of little clinical importance. The role of ddAVP in this population requires further research. JF - Journal of the American Medical Directors Association AU - Johnson, Theodore M AU - Miller, Myron AU - Tang, Terence AU - Pillion, Dennis J AU - Ouslander, Joseph G AD - The Birmingham/Atlanta VA Geriatric Research, Education, and Clinical Center, Atlanta, GA 30033, USA. Ted.Johnson@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 6 EP - 11 VL - 7 IS - 1 SN - 1525-8610, 1525-8610 KW - Antidiuretic Agents KW - 0 KW - Arginine Vasopressin KW - 113-79-1 KW - Sodium KW - 9NEZ333N27 KW - Deamino Arginine Vasopressin KW - ENR1LLB0FP KW - Index Medicus KW - Administration, Oral KW - Age Factors KW - Urodynamics KW - Diapers, Adult KW - Humans KW - Aged KW - Pilot Projects KW - Water Deprivation KW - Geriatric Assessment KW - Aged, 80 and over KW - Treatment Outcome KW - Sodium -- blood KW - Hyponatremia -- chemically induced KW - Time Factors KW - Female KW - Male KW - Nursing Homes KW - Hyponatremia -- blood KW - Antidiuretic Agents -- adverse effects KW - Arginine Vasopressin -- blood KW - Deamino Arginine Vasopressin -- therapeutic use KW - Enuresis -- metabolism KW - Enuresis -- diagnosis KW - Deamino Arginine Vasopressin -- adverse effects KW - Antidiuretic Agents -- therapeutic use KW - Enuresis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70683082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Directors+Association&rft.atitle=Oral+ddAVP+for+nighttime+urinary+incontinence+in+characterized+nursing+home+residents%3A+a+pilot+study.&rft.au=Johnson%2C+Theodore+M%3BMiller%2C+Myron%3BTang%2C+Terence%3BPillion%2C+Dennis+J%3BOuslander%2C+Joseph+G&rft.aulast=Johnson&rft.aufirst=Theodore&rft.date=2006-01-01&rft.volume=7&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Directors+Association&rft.issn=15258610&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-12 N1 - Date created - 2006-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Co-morbid traumatic brain injury and substance use disorder: childhood predictors and adult correlates. AN - 70671242; 16403699 AB - To examine demographic factors, childhood experiences and behaviour problems and adult psychopathology associated with a history of adult traumatic brain injury (TBI) with unconsciousness in patients with substance use disorders (SUD). Voluntary patients (n = 550) undergoing treatment for SUD were compared for clinical and demographic variables based on report of TBI. Among the 218 (40%) patients reporting TBI, 61% were men. Childhood conduct problems and loss of a parent were strongly associated with adult TBI. Patients with TBI had more severe SUD and higher rates of depressive and anxiety symptoms, somatic concerns, physical trauma, attempted suicide and Antisocial Personality Disorder. Men have a higher rate of TBI than women, but women with SUD have an increased relative risk of TBI compared to women in the general population. Childhood conduct problems and loss of a parent in childhood may predict adult risk-taking behaviour that leads to TBI in patients with SUD. TBI is associated with higher rates of psychopathology in patients with SUD. JF - Brain injury AU - Felde, Anne B AU - Westermeyer, Joseph AU - Thuras, Paul AD - Minneapolis VAMC, MN 55417, USA. Anne.Felde@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 41 EP - 49 VL - 20 IS - 1 SN - 0269-9052, 0269-9052 KW - Index Medicus KW - Humans KW - Aged KW - Antisocial Personality Disorder -- psychology KW - Comorbidity KW - Antisocial Personality Disorder -- complications KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Conduct Disorder -- complications KW - Conduct Disorder -- psychology KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Unconsciousness -- complications KW - Substance-Related Disorders -- complications KW - Substance-Related Disorders -- psychology KW - Brain Injuries -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70671242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+injury&rft.atitle=Co-morbid+traumatic+brain+injury+and+substance+use+disorder%3A+childhood+predictors+and+adult+correlates.&rft.au=Felde%2C+Anne+B%3BWestermeyer%2C+Joseph%3BThuras%2C+Paul&rft.aulast=Felde&rft.aufirst=Anne&rft.date=2006-01-01&rft.volume=20&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Brain+injury&rft.issn=02699052&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-03 N1 - Date created - 2006-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An evidence-based project to improve depression and alcohol use screening. AN - 70211476; 16340695 AB - Using research to improve practice is a high priority. Research shows that routine screening helps identify adults who are at risk for various disorders. Depression and alcohol use screening tools can improve evaluation and treatment. Nurses aimed to improve the screening rates for depression and alcohol use from the existing 50%-80% to 100% with a 1-hour educational program on depression screening and alcohol use disorders screening for 2 clinic areas: primary care and home-based care. Post program evaluation revealed that depression screening and alcohol use disorders screening rates increased to 100%. JF - Journal of nursing care quality AU - Valente, Sharon AU - Nemec, Constance AD - Department of Veterans Affairs, Los Angeles, CA 90049, USA. sharon.valente@med.va.gov PY - 2006 SP - 93 EP - 98 VL - 21 IS - 1 SN - 1057-3631, 1057-3631 KW - Index Medicus KW - Nursing KW - Nursing Methodology Research KW - Attitude of Health Personnel KW - Humans KW - Nursing Education Research KW - Outcome Assessment (Health Care) KW - Benchmarking KW - Home Care Services -- standards KW - Curriculum KW - Health Services Accessibility -- standards KW - Program Development KW - Nurse's Role KW - Program Evaluation KW - Primary Health Care -- standards KW - Alcohol-Related Disorders -- diagnosis KW - Evidence-Based Medicine -- education KW - Mass Screening -- psychology KW - Depressive Disorder -- diagnosis KW - Mass Screening -- standards KW - Education, Nursing, Continuing -- organization & administration KW - Total Quality Management -- organization & administration KW - Evidence-Based Medicine -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70211476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nursing+care+quality&rft.atitle=An+evidence-based+project+to+improve+depression+and+alcohol+use+screening.&rft.au=Valente%2C+Sharon%3BNemec%2C+Constance&rft.aulast=Valente&rft.aufirst=Sharon&rft.date=2006-01-01&rft.volume=21&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+nursing+care+quality&rft.issn=10573631&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-14 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Validation of the primary care alcohol severity measure. AN - 70197397; 16340622 AB - Alcohol-related disorders are common in primary care settings; many primary care physicians are ill-equipped to manage patients with alcohol-related disorders. The objective of this prospective cohort study was to develop and validate a patient-based measure, the Primary Care Alcohol Severity Measure, to determine which primary care patients with alcohol-related disorders would benefit from referral to alcohol treatment services. Four Boston-area Department of Veterans Affairs ambulatory care clinics were chosen as study sites. Two hundred seventy-eight male patients, mean age 55.5 years, 89.9% Caucasian, 42.5% married, all with CAGE Questionnaire scores greater than or equal to 2 and drinking within past year, participated in the study. We developed a multidimensional, 30-item measure that contained 2 subscales that assessed 2 symptom clusters of alcohol-related disorders: Physical and Behavioral. Each subscale's score was higher (more severe) for patients with a current Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised diagnosis of alcohol dependence or abuse: P < .01 for the physical subscale and P < .0001 for the behavioral subscale. Patients with more physical symptoms had poorer physical and mental health status, whereas patients with more behavioral symptoms had poorer mental health status. Scores on the 2 subscales, along with age and history of prior treatment, predicted the use of alcohol treatment services in the following year: c = 0.90 in logistic regression. The Primary Care Alcohol Severity Measure is a valid measure of alcohol severity in primary care patients and predicts the use of alcohol treatment services. It is relatively brief and easy to use, requiring only standard medical history items and patient reports of behavioral symptoms. It may be a useful tool to improve the quality of care for primary care patients with alcohol-related disorders. JF - The Journal of ambulatory care management AU - Mansell, Dorcas AU - Spiro, Avron AU - Lee, Austin AU - Kazis, Lewis AD - University of Alabama at Birmingham School of Medicine and Birmingham VAMC, Birmingham, Tuscaloosa, AL 35404, USA. Dorcas.Mansell@med.va.gov PY - 2006 SP - 87 EP - 97 VL - 29 IS - 1 SN - 0148-9917, 0148-9917 KW - Health administration KW - Veterans KW - United States KW - Outpatients KW - Prospective Studies KW - Aged, 80 and over KW - Humans KW - Cohort Studies KW - Adult KW - Aged KW - Middle Aged KW - Boston -- epidemiology KW - Male KW - Alcoholism -- epidemiology KW - Alcoholism -- classification KW - Surveys and Questionnaires KW - Primary Health Care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70197397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+ambulatory+care+management&rft.atitle=Validation+of+the+primary+care+alcohol+severity+measure.&rft.au=Mansell%2C+Dorcas%3BSpiro%2C+Avron%3BLee%2C+Austin%3BKazis%2C+Lewis&rft.aulast=Mansell&rft.aufirst=Dorcas&rft.date=2006-01-01&rft.volume=29&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+ambulatory+care+management&rft.issn=01489917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The illness burden of alcohol-related disorders among VA patients: the veterans health study. AN - 70193924; 16340620 AB - Little is known about the illness burden associated with alcohol-related disorders (ie, problem drinking, alcohol abuse, and alcohol dependence) among patients in outpatient medical care. The objective of this study was to examine several aspects of illness burden-medical comorbidities, patterns of health services use, and functional status-among Veterans Health Administration (VA) ambulatory care patients with alcohol-related disorders. Male participants (N = 2425) were recruited at 1 of 4 Boston-area VA outpatient clinics. They completed self-report screening measures of current alcohol-related disorders (CAGE score > or =2 with past year alcohol consumption), health behaviors, medical comorbidities, and functional status (SF-36). A medical history interview, which assessed comorbid conditions and use of recent health services, was also administered. Screening criteria for current alcohol-related disorders were satisfied by 12%; however, only 40% of these reported ever receiving treatment specifically for alcohol-related disorders. Patients who screened positive for alcohol-related disorders reported significantly greater limitations in mental health function, longer hospitalizations for medical care in the prior year, and fewer outpatient medical visits in the previous 3 months. Findings suggest considerable illness burden associated with alcohol-related disorders among VA ambulatory care patients. Efforts to increase detection and treatment of alcohol-related disorders may lessen the illness burden and cost of alcohol-related disorders. JF - The Journal of ambulatory care management AU - Mansell, Dorcas AU - Penk, Walter AU - Hankin, Cheryl S AU - Lee, Austin AU - Spiro, Avron AU - Skinner, Katherine M AU - Hsieh, Juling AU - Kazis, Lewis E AD - University of Alabama at Birmingham School of Medicine and Birmingham VAMC, Tuscaloosa, AL 35404, USA. Dorcas.Mansell@med.va.gov PY - 2006 SP - 61 EP - 70 VL - 29 IS - 1 SN - 0148-9917, 0148-9917 KW - Health administration KW - United States KW - Aged, 80 and over KW - United States Department of Veterans Affairs KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Cost of Illness KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70193924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+ambulatory+care+management&rft.atitle=The+illness+burden+of+alcohol-related+disorders+among+VA+patients%3A+the+veterans+health+study.&rft.au=Mansell%2C+Dorcas%3BPenk%2C+Walter%3BHankin%2C+Cheryl+S%3BLee%2C+Austin%3BSpiro%2C+Avron%3BSkinner%2C+Katherine+M%3BHsieh%2C+Juling%3BKazis%2C+Lewis+E&rft.aulast=Mansell&rft.aufirst=Dorcas&rft.date=2006-01-01&rft.volume=29&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+ambulatory+care+management&rft.issn=01489917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adjunctive risperidone treatment and sleep symptoms in combat veterans with chronic PTSD. AN - 69025078; 16845653 AB - Sleep disturbances are core symptoms of posttraumatic stress disorder (PTSD) and are often resistant to treatment. One reason for the recent use of atypical antipsychotics in PTSD appears to be their effects on sleep. Study objectives were (1) to evaluate preliminarily the sleep effects of adjunctive risperidone, and (2) to evaluate the use of sleep diaries versus the more standard retrospective sleep assessments. This was a pilot, open-label, 12-week, flexible-dose trial of adjunctive risperidone in male veterans with a primary diagnosis of chronic, combat-related PTSD, partially responsive to current medications. Diagnostic interviews were administered at baseline, and PTSD ratings were obtained at baseline and at 6 and 12 weeks. Self-report sleep measures, including morning logs, were obtained at baseline and 6 weeks. Seventeen patients completed at least 6 weeks of the trial. Global ratings of sleep disturbance improved. Changes in frequency of awakenings and reductions in trauma-related dreams were only evident via morning log assessments. Nighttime awakening frequency derived from the sleep logs but not from the Pittsburgh Sleep Quality Index (PSQI) decreased significantly. There were no changes in the PSQI nightmare item; however, sleep log data indicated a reduced proportion of traumatic dreams at 6 weeks. Preliminary results suggest that adjunctive risperidone may benefit sleep disturbances associated with chronic PTSD. Prospective logs may be more sensitive to change than are retrospective scales. Published 2006 Wiley-Liss, Inc. JF - Depression and anxiety AU - David, Daniella AU - De Faria, Ludmila AU - Mellman, Thomas A AD - Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, FL 33125, USA. daniella.david@va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 489 EP - 491 VL - 23 IS - 8 SN - 1091-4269, 1091-4269 KW - Antipsychotic Agents KW - 0 KW - Risperidone KW - L6UH7ZF8HC KW - Index Medicus KW - Drug Therapy, Combination KW - Medical Records KW - Prospective Studies KW - Humans KW - Retrospective Studies KW - Aged KW - Pilot Projects KW - Middle Aged KW - Chronic Disease KW - Male KW - Vietnam KW - Combat Disorders -- psychology KW - Combat Disorders -- drug therapy KW - Dyssomnias -- diagnosis KW - Antipsychotic Agents -- therapeutic use KW - Veterans -- psychology KW - Dyssomnias -- drug therapy KW - Combat Disorders -- diagnosis KW - Risperidone -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Risperidone -- therapeutic use KW - Dyssomnias -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69025078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+anxiety&rft.atitle=Adjunctive+risperidone+treatment+and+sleep+symptoms+in+combat+veterans+with+chronic+PTSD.&rft.au=David%2C+Daniella%3BDe+Faria%2C+Ludmila%3BMellman%2C+Thomas+A&rft.aulast=David&rft.aufirst=Daniella&rft.date=2006-01-01&rft.volume=23&rft.issue=8&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Depression+and+anxiety&rft.issn=10914269&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-14 N1 - Date created - 2006-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bagoas. AN - 68789611; 16939172 JF - The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha AU - Mackowiak, Philip A AD - University of Maryland School of Medicine, 21201, USA. Philip.Mackowiak@med.va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 26 EP - 28 VL - 69 IS - 3 SN - 0031-7179, 0031-7179 KW - Index Medicus KW - Alexander the Great KW - Acute Disease KW - Greece KW - Humans KW - History, Ancient KW - Male KW - Alcoholic Intoxication -- history KW - Fever -- history KW - Famous Persons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68789611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Pharos+of+Alpha+Omega+Alpha-Honor+Medical+Society.+Alpha+Omega+Alpha&rft.atitle=Bagoas.&rft.au=Mackowiak%2C+Philip+A&rft.aulast=Mackowiak&rft.aufirst=Philip&rft.date=2006-01-01&rft.volume=69&rft.issue=3&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=The+Pharos+of+Alpha+Omega+Alpha-Honor+Medical+Society.+Alpha+Omega+Alpha&rft.issn=00317179&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-26 N1 - Date created - 2006-08-30 N1 - Date revised - 2017-01-13 N1 - People - Alexander the Great N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Alexander the Great ER - TY - JOUR T1 - Some effects of multiple sclerosis on speech perception in noise: Preliminary findings. AN - 68649936; 16847775 AB - The present investigation examined speech perception in noise of adults with and without multiple sclerosis (MS). Institute of Electrical and Electronic Engineers (IEEE) sentences were presented at a constant level of 65 dBA L(eq) (equivalent continuous noise level [4 dB exchange rate]) from a loudspeaker located at 0-degree horizontal azimuth and 1.2 m from the study participant. Uncorrelated multitalker babble was presented from four loudspeakers positioned at 45-, 135-, 225-, and 315-degree azimuths and 1.7 m from the study participant. The starting presentation level for the babble was 55 dBA L(eq). The level of the babble was increased systematically in 1 dB steps until the subject obtained 0% key words correct on the IEEE sentences. Results revealed a significant difference in speech perception between the two groups at nine signal-to-noise ratios. Some clinical implications of these results are discussed. JF - Journal of rehabilitation research and development AU - Lewis, M Samantha AU - Lilly, David J AU - Hutter, Michele AU - Bourdette, Dennis N AU - Saunders, Julie AU - Fausti, Stephen A AD - Department of Veterans Affairs (VA) National Center for Rehabilitative Auditory Research, Portland VA Medical Center (VAMC), Portland, OR 97207, USA. Michele.Lewis3@med.va.gov PY - 2006 SP - 91 EP - 98 VL - 43 IS - 1 KW - Index Medicus KW - United States KW - Severity of Illness Index KW - Reference Values KW - Audiometry KW - Humans KW - Prognosis KW - Aged KW - United States Department of Veterans Affairs KW - Adult KW - Case-Control Studies KW - Incidence KW - Middle Aged KW - Female KW - Male KW - Speech Perception KW - Hearing Disorders -- etiology KW - Hearing Disorders -- epidemiology KW - Multiple Sclerosis -- complications KW - Hearing Disorders -- diagnosis KW - Noise KW - Multiple Sclerosis -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68649936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+rehabilitation+research+and+development&rft.atitle=Some+effects+of+multiple+sclerosis+on+speech+perception+in+noise%3A+Preliminary+findings.&rft.au=Lewis%2C+M+Samantha%3BLilly%2C+David+J%3BHutter%2C+Michele%3BBourdette%2C+Dennis+N%3BSaunders%2C+Julie%3BFausti%2C+Stephen+A&rft.aulast=Lewis&rft.aufirst=M&rft.date=2006-01-01&rft.volume=43&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Journal+of+rehabilitation+research+and+development&rft.issn=1938-1352&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2006-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The use of botulinum toxin in physical medicine and rehabilitation. AN - 68401394; 19610549 AB - A review of the history and pharmacology of the botulinum neurotoxins is presented. Established mechanisms of action are discussed as well as preliminary evidence of other potential mechanisms, as related to botulinum toxins' antinociceptive properties. Methods of administration, including reconstitution, dilution, and basic injection techniques/principles are reviewed. Safety concerns are also addressed. Various applications relevant to the field of Physical Medicine & Rehabilitation are reviewed, specifically uses in the management of muscle over activity syndromes such as upper motor neuron-related spasticity, dystonias, and painful syndromes including Myofascial Pain Syndromes and headaches. Relevant literature related to these applications is reviewed and discussed. Botulinum toxin therapeutic efficacy and possible reasons for treatment failure (including development of antibody-mediated resistance) are discussed. JF - Boletin de la Asociacion Medica de Puerto Rico AU - Cuevas-Trisán, Ramón L AU - Cruz-Jiménez, Maricarmen AD - Physical Medicine & Rehabilitation Service, West Palm Beach Veterans Affairs Medical Center, FL 33410-6400, USA. ramon.cuevas-trisan@med.va.gov PY - 2006 SP - 42 EP - 55 VL - 98 IS - 1 SN - 0004-4849, 0004-4849 KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Index Medicus KW - Myofascial Pain Syndromes -- rehabilitation KW - Headache -- rehabilitation KW - Muscle Spasticity -- drug therapy KW - Rehabilitation -- methods KW - Physical Therapy Modalities KW - Myofascial Pain Syndromes -- drug therapy KW - Humans KW - Dystonia -- rehabilitation KW - Headache -- drug therapy KW - Muscle Spasticity -- rehabilitation KW - Dystonia -- drug therapy KW - Botulinum Toxins -- administration & dosage KW - Botulinum Toxins -- therapeutic use KW - Botulinum Toxins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68401394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Boletin+de+la+Asociacion+Medica+de+Puerto+Rico&rft.atitle=The+use+of+botulinum+toxin+in+physical+medicine+and+rehabilitation.&rft.au=Cuevas-Tris%C3%A1n%2C+Ram%C3%B3n+L%3BCruz-Jim%C3%A9nez%2C+Maricarmen&rft.aulast=Cuevas-Tris%C3%A1n&rft.aufirst=Ram%C3%B3n&rft.date=2006-01-01&rft.volume=98&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Boletin+de+la+Asociacion+Medica+de+Puerto+Rico&rft.issn=00044849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-12 N1 - Date created - 2009-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Megestrol acetate in cachexia and anorexia. AN - 68353823; 17722275 AB - The aim is to review major clinical trials that have used megestrol acetate (MA) in the treatment of cachexia across several disease states. A review of general usage and potential side-effects are discussed. A theory that the newly approved nanocrystal formation of MA can better deliver this potent medication for treatment will also be reviewed. JF - International journal of nanomedicine AU - Yeh, Shing-Shing AU - Schuster, Michael W AD - Northport VAMC, Geriatric division, Northport, NY 11768, USA. shingshing.yeh@med.va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 411 EP - 416 VL - 1 IS - 4 SN - 1176-9114, 1176-9114 KW - Drug Carriers KW - 0 KW - Megestrol Acetate KW - TJ2M0FR8ES KW - Index Medicus KW - Humans KW - Drug Carriers -- chemistry KW - Nanoparticles -- chemistry KW - Megestrol Acetate -- therapeutic use KW - Cachexia -- drug therapy KW - Anorexia -- drug therapy KW - Megestrol Acetate -- adverse effects KW - Clinical Trials as Topic -- trends KW - Megestrol Acetate -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68353823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+nanomedicine&rft.atitle=Megestrol+acetate+in+cachexia+and+anorexia.&rft.au=Yeh%2C+Shing-Shing%3BSchuster%2C+Michael+W&rft.aulast=Yeh&rft.aufirst=Shing-Shing&rft.date=2006-01-01&rft.volume=1&rft.issue=4&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=International+journal+of+nanomedicine&rft.issn=11769114&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nutrition. 1999 Apr;15(4):294-8 [10319362] JAMA. 1999 Jun 2;281(21):2013-9 [10359390] J Clin Oncol. 1999 Oct;17(10):3299-306 [10506633] JAMA. 1987 Mar 6;257(9):1195-8 [3806918] J Steroid Biochem. 1987 Mar;26(3):313-9 [2953940] Ann Intern Med. 1988 Nov 15;109(10):840-1 [3190032] Semin Oncol. 1991 Feb;18(1 Suppl 2):35-42 [1992535] Drugs. 1992 Apr;43(4):499-506 [1377116] Am J Clin Oncol. 1992 Oct;15(5):436-40 [1524045] Oncology. 1992;49 Suppl 2:46-9 [1461628] Mayo Clin Proc. 1992 Dec;67(12):1160-2 [1469926] J Clin Oncol. 1993 Apr;11(4):762-7 [8478668] J Acquir Immune Defic Syndr. 1994 Jun;7(6):580-6 [8176641] Ann Intern Med. 1994 Sep 15;121(6):400-8 [8053613] JAMA. 1994 Nov 23-30;272(20):1601-6 [7966871] Cochrane Database Syst Rev. 2005;(2):CD004310 [15846706] J Am Geriatr Soc. 2005 Jun;53(6):970-5 [15935019] BioDrugs. 2005;19(3):179-87 [15984902] J Am Geriatr Soc. 1995 Apr;43(4):329-37 [7706619] J Periodontol. 1995 Apr;66(4):279-84 [7782982] J Gerontol A Biol Sci Med Sci. 1995 Nov;50 Spec No:101-6 [7493200] J Natl Cancer Inst Monogr. 1996;(20):79-80 [8750472] Oncology (Williston Park). 1996 Jul;10(7):1049-56; discussion 1062-4, 1067-8 [8837121] Steroids. 1996 Mar;61(3):133-7 [8852830] Am J Clin Nutr. 1997 Mar;65(3):717-23 [9062520] Proc Nutr Soc. 1997 Mar;56(1A):25-40 [9168518] Arch Intern Med. 1997 Aug 11-25;157(15):1651-6 [9250225] Adv Exp Med Biol. 1997;411:83-9 [9269414] Support Care Cancer. 1997 Sep;5(5):422-3 [9322357] Clin Geriatr Med. 1997 Nov;13(4):717-35 [9354751] J Reprod Fertil Suppl. 1997;51:345-54 [9404305] J Am Geriatr Soc. 2000 May;48(5):485-92 [10811540] Eur J Clin Nutr. 2000 Jun;54 Suppl 3:S64-9 [11041077] J Gerontol A Biol Sci Med Sci. 2001 Jan;56(1):M48-54 [11193233] J Nutr Health Aging. 2000;4(4):246-51 [11115810] Gynecol Endocrinol. 2001 Oct;15(5):341-8 [11727356] Circulation. 2001 Dec 4;104(23):2826-31 [11733402] J Clin Oncol. 2002 Jan 15;20(2):567-73 [11786587] Clin Diagn Lab Immunol. 2002 May;9(3):583-7 [11986264] J Clin Endocrinol Metab. 2002 May;87(5):2100-6 [11994348] Pediatr Pulmonol. 2002 Nov;34(5):381-3 [12357484] Chest. 2003 Jan;123(1):309-10; author reply 310 [12527643] J Pediatr Hematol Oncol. 2003 May;25(5):414-7 [12759631] Neoplasma. 2003;50(3):227-33 [12937858] J Am Med Dir Assoc. 2003 Sep-Oct;4(5):255-6 [12959653] J Am Med Dir Assoc. 2004 Jan-Feb;5(1):24-30 [14706125] J Am Med Dir Assoc. 2004 Jan-Feb;5(1):65-6; author reply 66-7 [14726802] Clin Infect Dis. 2004 Mar 15;38(6):895-902 [14999637] J Pain Symptom Manage. 2004 Apr;27(4):360-9 [15050664] J Clin Oncol. 2004 Jun 15;22(12):2469-76 [15197210] J Am Geriatr Soc. 2004 Oct;52(10):1708-12 [15450049] J Pharm Pharmacol. 2004 Oct;56(10):1233-41 [15482637] Urol Int. 1979;34(5):330-8 [494436] Biochem Pharmacol. 1983 May 1;32(9):1511-8 [6222739] Cancer Chemother Pharmacol. 1984;12(2):83-6 [6321047] Cancer Chemother Pharmacol. 1985;15(2):167-70 [3160504] Oncology. 1994 Oct;51 Suppl 1:19-24 [7970504] Oncology. 1994 Oct;51 Suppl 1:2-7 [7970505] Am J Physiol. 1998 Feb;274(2 Pt 2):R420-7 [9486300] Br J Nutr. 1998 Jan;79(1):107-13 [9505809] Am J Med. 1998 Jan;104(1):40-7 [9528718] Semin Oncol. 1998 Apr;25(2 Suppl 6):45-52 [9625383] Semin Oncol. 1998 Apr;25(2 Suppl 6):58-61 [9625385] J Neuroendocrinol. 1998 Sep;10(9):719-27 [9744490] Clin Immunol Immunopathol. 1998 Dec;89(3):231-9 [9837693] Crit Rev Oncog. 1998;9(2):99-106 [9973244] JAMA. 1999 Apr 14;281(14):1282-90 [10208143] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Outpatient treatment engagement and abstinence rates following inpatient opioid detoxification. AN - 68121873; 17088223 AB - Many patients with chronic opioid dependence are referred to drug-free outpatient treatment following inpatient detoxification even though successful outpatient treatment engagement and abstinence from opioids occur only in a minority of cases. This retrospective cohort analysis of medical records documents the post-discharge outcome in a treatment setting that maximizes the support during transition to abstinence-oriented outpatient care, with comprehensive social, medical and mental health services, including the availability of naltrexone. Participants were male veterans (N = 112) admitted at an urban VA medical center. Most patients (78%) successfully completed acute detoxification, 49% initiated naltrexone, and 76% accepted a VA aftercare plan. At 90-day follow-up, only 22% remained in aftercare, and < 3% had toxicology-verified abstinence from opioids. At one-year follow-up, 1 out of 5 had been readmitted for detoxification and 4.5% had died. Most patients successfully detoxified from opioids, but very few remained engaged and stabilized in abstinence-oriented outpatient treatment. JF - Journal of addictive diseases AU - Davison, John W AU - Sweeney, Marie L AU - Bush, Kristen R AU - Davis Correale, Tania M AU - Calsyn, Donald A AU - Reoux, Joseph P AU - Sloan, Kevin L AU - Kivlahan, Daniel R AD - Va Puget Sound Health Care System, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seatte, WA 98195, USA. John.Davison@va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 27 EP - 35 VL - 25 IS - 4 SN - 1055-0887, 1055-0887 KW - Narcotic Antagonists KW - 0 KW - Naltrexone KW - 5S6W795CQM KW - Index Medicus KW - Veterans KW - Aftercare -- statistics & numerical data KW - Psychotherapy, Group KW - Length of Stay -- statistics & numerical data KW - Humans KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Hospitalization -- statistics & numerical data KW - Time Factors KW - Male KW - Patient Compliance -- statistics & numerical data KW - Opioid-Related Disorders -- epidemiology KW - Inactivation, Metabolic KW - Narcotic Antagonists -- therapeutic use KW - Ambulatory Care -- statistics & numerical data KW - Opioid-Related Disorders -- rehabilitation KW - Naltrexone -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68121873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+addictive+diseases&rft.atitle=Outpatient+treatment+engagement+and+abstinence+rates+following+inpatient+opioid+detoxification.&rft.au=Davison%2C+John+W%3BSweeney%2C+Marie+L%3BBush%2C+Kristen+R%3BDavis+Correale%2C+Tania+M%3BCalsyn%2C+Donald+A%3BReoux%2C+Joseph+P%3BSloan%2C+Kevin+L%3BKivlahan%2C+Daniel+R&rft.aulast=Davison&rft.aufirst=John&rft.date=2006-01-01&rft.volume=25&rft.issue=4&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Journal+of+addictive+diseases&rft.issn=10550887&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-21 N1 - Date created - 2006-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational hand infections. AN - 67918970; 16647654 AB - Prompt diagnosis and treatment of hand and upper extremity infections is imperative because they have the potential to be life threatening and pose a risk of functional impairment. Serious infections may result in prolonged hospitalization and resultant loss of productivity. The mainstay of treatment continues to be antibiotic therapy, heat, elevation, adequate surgical drainage, and débridement. Prompt specialty consultation should be obtained in cases in which there is a doubt about the diagnosis or when there is failure to improve in the face of seemingly appropriate treatment. JF - Clinics in occupational and environmental medicine AU - Gaar, Earl AD - Department of Surgery, University of Louisville School of Medicine, 529 South Jackson Street, Louisville, KY 40202, USA. earl.gaar@med.va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 369 EP - 80, viii VL - 5 IS - 2 SN - 1526-0046, 1526-0046 KW - Anti-Infective Agents KW - 0 KW - Index Medicus KW - Occupational Health KW - Tenosynovitis -- diagnosis KW - Drainage KW - Humans KW - Bites and Stings -- complications KW - Paronychia -- diagnosis KW - Anti-Infective Agents -- therapeutic use KW - Treatment Outcome KW - Suppuration KW - Debridement KW - Cellulitis -- diagnosis KW - Infection Control KW - Arthritis, Infectious -- diagnosis KW - Early Diagnosis KW - Hand Injuries -- complications KW - Occupational Medicine KW - Occupational Diseases -- diagnosis KW - Hand Dermatoses -- epidemiology KW - Skin Diseases, Infectious -- etiology KW - Skin Diseases, Infectious -- epidemiology KW - Hand Dermatoses -- diagnosis KW - Skin Diseases, Infectious -- diagnosis KW - Occupational Diseases -- etiology KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- therapy KW - Hand Dermatoses -- etiology KW - Skin Diseases, Infectious -- therapy KW - Hand Dermatoses -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67918970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+occupational+and+environmental+medicine&rft.atitle=Occupational+hand+infections.&rft.au=Gaar%2C+Earl&rft.aulast=Gaar&rft.aufirst=Earl&rft.date=2006-01-01&rft.volume=5&rft.issue=2&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Clinics+in+occupational+and+environmental+medicine&rft.issn=15260046&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-30 N1 - Date created - 2006-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Guillain-Barré syndrome as a cause of reversible cardiomyopathy. AN - 67812778; 16572872 AB - Although autonomic dysfunction is a common manifestation of Guillain-Barré syndrome, cardiovascular involvement in this setting has rarely been reported in the literature. We describe a case of reversible left ventricular systolic dysfunction in a 60-year-old man with Guillain-Barré syndrome. Our patient had no history or signs of cardiac dysfunction on initial presentation. During the clinical manifestation of his autonomic dysfunction, he developed electrocardiographic changes accompanied by mildly elevated cardiac enzymes and severe left ventricular systolic dysfunction and segmental wall motion abnormality, which coincided with elevated urinary catecholamine and vanilmandelic acid levels. These abnormalities, and his symptoms, resolved rapidly once the acute episode was over. We believe the reversible left ventricular dysfunction was due to the toxic effect of increased catecholamines and to the transiently damaged sympathetic nerve endings in the myocardium, presumably a consequence of Guillain-Barré syndrome. We recommend that echocardiography be performed in patients with clinical signs of autonomic dysfunction, especially if they are associated with abnormal electrocardiographic findings, cardiac enzyme elevation, or hemodynamic instability, so that appropriate medical therapy can be instituted in a timely manner. JF - Texas Heart Institute journal AU - Finkelstein, Jason S AU - Melek, Bekir H AD - Department of Medicine, Section of Cardiology, Veterans Administration Medical Center and Tulane University School of Medicine, New Orleans, Louisiana 70112, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 57 EP - 59 VL - 33 IS - 1 SN - 0730-2347, 0730-2347 KW - Index Medicus KW - Humans KW - Middle Aged KW - Male KW - Ventricular Dysfunction, Left -- etiology KW - Guillain-Barre Syndrome -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67812778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Texas+Heart+Institute+journal&rft.atitle=Guillain-Barr%C3%A9+syndrome+as+a+cause+of+reversible+cardiomyopathy.&rft.au=Finkelstein%2C+Jason+S%3BMelek%2C+Bekir+H&rft.aulast=Finkelstein&rft.aufirst=Jason&rft.date=2006-01-01&rft.volume=33&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Texas+Heart+Institute+journal&rft.issn=07302347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-30 N1 - Date created - 2006-03-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cleve Clin J Med. 2007 Feb;74 Suppl 1:S8-16 [17455536] Neurology. 2000 Feb 8;54(3):759-62 [10680822] Acta Neurol Scand. 2002 Jan;105(1):44-50 [11903108] Jpn Circ J. 1995 Apr;59(4):236-40 [7658618] Intensive Care Med. 1980;6(1):3-6 [7356703] Jpn J Med. 1985 Feb;24(1):24-9 [3999461] Acta Neurol Scand. 1987 Feb;75(2):101-5 [3577674] No To Shinkei. 2003 Jun;55(6):517-20 [12884804] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug injury in the upper gastrointestinal tract: nonsteroidal anti-inflammatory drugs. AN - 67762735; 16546025 AB - It is well established that nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin confer significant morbidity and mortality. The widespread use of these drugs has increased the absolute numbers of cases of NSAID- or aspirin-related upper gastrointestinal complications. Emerging data indicate that antidepressants, such as selective serotonin reuptake inhibitors and tricyclic antidepressants, may also increase risk for gastrointestinal bleeding. Multiple factors have been identified that increase risk for NSAID- and aspirin-related upper gastrointestinal complications. The highest risks are related to age (>60 years) and prior complicated peptic ulcer; additional risk factors include use of multiple NSAIDs and high doses of NSAIDS. Recent studies have demonstrated enhanced healing and prevention of NSAID- and aspirin-related gastrointestinal lesions with proton pump inhibitors. JF - Gastrointestinal endoscopy clinics of North America AU - Go, Mae F AD - Veterans Administration Salt Lake City Health Care System, UT 84106, USA. mae.go@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 83 EP - 97 VL - 16 IS - 1 SN - 1052-5157, 1052-5157 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Proton Pump Inhibitors KW - Serotonin Uptake Inhibitors KW - Omeprazole KW - KG60484QX9 KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Omeprazole -- pharmacology KW - Animals KW - Sex Factors KW - Aspirin -- adverse effects KW - Risk Factors KW - Humans KW - Middle Aged KW - Serotonin Uptake Inhibitors -- pharmacology KW - Peptic Ulcer -- epidemiology KW - Female KW - Gastrointestinal Tract -- drug effects KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67762735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastrointestinal+endoscopy+clinics+of+North+America&rft.atitle=Drug+injury+in+the+upper+gastrointestinal+tract%3A+nonsteroidal+anti-inflammatory+drugs.&rft.au=Go%2C+Mae+F&rft.aulast=Go&rft.aufirst=Mae&rft.date=2006-01-01&rft.volume=16&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Gastrointestinal+endoscopy+clinics+of+North+America&rft.issn=10525157&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-23 N1 - Date created - 2006-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of noise on the morphology of the intestinal mucosa in laboratory rats. AN - 67755659; 16539340 AB - To determine whether noise-induced stress disrupts the intestinal mucosa of laboratory rats, one group of 8 rats ("noise" rats) was subjected to 15 min of white noise (90 dB) daily for 3 wk. Another group ("quiet"rats) was housed for 3 wk in an acoustically similar room but with no additional noise. A 3rd group ("recovery" rats) was housed in the noise room for 3 wk and then in the quiet room for a further 3 wk. The ilea were fixed for microscopy. Villi adjacent to Peyer patches showed significantly more degranulated mast cells (mean+/-standard error of the mean, 3.95+/-0.80 versus 0.35+/-0.29, respectively) and eosinophils (mean+/-standard error of the mean, 9.46+/-0.44 versus 4.58+/-0.38) per villus section in noise rats than in quiet rats. Similar results were obtained with rooms reversed, to account for any differences in room characteristics. The mean width of villus laminar propria was significantly greater in noise rats than quiet rats, suggesting edema. In addition, mucosal epithelial cells of noise rats were often separated, sometimes detaching from the basement membrane, whereas those of quiet rats were intact. Behaviorally, noise rats exhibited significantly more grooming and rearing than quiet rats. Compared with noise rats, recovery rats showed no reduction in mast cell degranulation or mean width of villus lamina propria, but there were increased numbers of secreting goblet cells in villi adjacent to Peyer patches and some recovery of epithelial integrity. JF - Journal of the American Association for Laboratory Animal Science : JAALAS AU - Baldwin, Ann L AU - Primeau, Richard L AU - Johnson, William E AD - Department of Physiology, University of Arizona and Veterans Administration Medical Center, Tucson, AZ, USA. abaldwin@u.arizona.edu Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 74 EP - 82 VL - 45 IS - 1 SN - 1559-6109, 1559-6109 KW - Index Medicus KW - Animals KW - Rats, Sprague-Dawley KW - Mast Cells -- pathology KW - Animal Welfare KW - Feeding Behavior KW - Mast Cells -- ultrastructure KW - Male KW - Behavior, Animal KW - Laboratory Animal Science KW - Intestinal Mucosa -- ultrastructure KW - Rats -- psychology KW - Noise KW - Stress, Psychological -- pathology KW - Intestinal Mucosa -- pathology KW - Rats -- anatomy & histology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67755659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Association+for+Laboratory+Animal+Science+%3A+JAALAS&rft.atitle=Effect+of+noise+on+the+morphology+of+the+intestinal+mucosa+in+laboratory+rats.&rft.au=Baldwin%2C+Ann+L%3BPrimeau%2C+Richard+L%3BJohnson%2C+William+E&rft.aulast=Baldwin&rft.aufirst=Ann&rft.date=2006-01-01&rft.volume=45&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Association+for+Laboratory+Animal+Science+%3A+JAALAS&rft.issn=15596109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-24 N1 - Date created - 2006-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Increasing survival with HIV: impact on nursing care. AN - 67633963; 16462404 AB - The introduction of highly active antiretroviral therapy (HAART) has transformed human immunodeficiency virus (HIV) infection from a rapidly progressive catastrophic illness to a chronic condition. Individuals with HIV are living longer and developing conditions usually associated with aging, as well as complications from pre-existing or subsequently acquired conditions. In addition, toxicities associated with HAART may precipitate or exacerbate comorbid conditions. As opportunistic infections account for fewer admission and lower mortality rates, new patterns of illness are emerging. Complex interactions among multiple, sometimes overlapping conditions require focused yet comprehensive attention in care and management. Nurses will encounter HIV-infected patients in an increasing range of care settings, and an understanding of the range and interaction of potential comorbidities and their treatments with HIV and its treatment will be required to provide safe and effective care. JF - AACN clinical issues AU - Halloran, James AD - Department of Veterans Affairs, Public Health Strategic Healthcare Group, Center for Quality Management in Public Health, San Antonio, USA. james.halloran@va.gov PY - 2006 SP - 8 EP - 17 VL - 17 IS - 1 SN - 1079-0713, 1079-0713 KW - Anti-HIV Agents KW - 0 KW - Nursing KW - Health Services Needs and Demand KW - Drug Interactions KW - Humans KW - Aging KW - Disease Progression KW - Patient Care Planning KW - Safety Management KW - Comorbidity KW - Longevity KW - Risk Assessment KW - Patient Education as Topic KW - Survival Rate KW - Patient-Centered Care -- organization & administration KW - Nursing Assessment KW - Drug Monitoring -- nursing KW - HIV-1 -- growth & development KW - Chronic Disease KW - HIV-1 -- drug effects KW - Continuity of Patient Care KW - HIV Infections -- virology KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- therapy KW - Antiretroviral Therapy, Highly Active -- nursing KW - Anti-HIV Agents -- adverse effects KW - Nurse's Role KW - HIV Infections -- mortality KW - Anti-HIV Agents -- classification KW - HIV Infections -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67633963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AACN+clinical+issues&rft.atitle=Increasing+survival+with+HIV%3A+impact+on+nursing+care.&rft.au=Halloran%2C+James&rft.aulast=Halloran&rft.aufirst=James&rft.date=2006-01-01&rft.volume=17&rft.issue=1&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=AACN+clinical+issues&rft.issn=10790713&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-20 N1 - Date created - 2006-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recent sexual abuse, physical abuse, and suicide attempts among male veterans seeking psychiatric treatment. AN - 67613800; 16399970 AB - This study examined the rates of sexual and physical abuse and suicide attempts among male and female patients and focused on the associations between sexual and physical abuse and recent suicide attempts among men. Data were examined for a cohort of patients aged 19 years and older who were seeking treatment for substance use disorders, other psychiatric disorders, or both from the Department of Veterans Affairs (VA) between July 1997 and September 1997. Almost all the patients in the sample (more than 99 percent) had a substance use disorder. Patients were interviewed with the Addiction Severity Index about lifetime and recent (past 30 days) sexual and physical abuse and recent suicide attempts. Because of the low prevalence of suicide attempts in the past 30 days and limited representation of female patients in this sample, the data for female patients were used only to conduct descriptive analyses to compare the prevalence of sexual and physical abuse and suicide attempts between genders. The sample comprised 34,245 patients (33,236 males and 1,009 females). Compared with male patients, female patients were ten times as likely to have been sexually abused in the past 30 days and four times as likely to have been physically abused. Among male patients, bivariate analyses showed that those who had been recently sexually or physically abused were more likely than those who had not experienced such abuse to have attempted suicide recently (odds ratios of 4.8 and 3.0, respectively). After controlling for demographic and diagnostic factors, multivariate logistic regression analyses indicated that recent sexual abuse, recent physical abuse, and lifetime sexual abuse were significantly associated with a higher likelihood of a recent suicide attempt among male patients. Female patients were more likely than their male counterparts to experience sexual and physical abuse. Recent and lifetime history of sexual abuse and recent physical abuse were independent risk factors for recent suicide attempts among men who were seeking treatment. The results suggest that clinicians who identify suicide attempts and suicidal tendencies among male patients should routinely assess for sexual or physical abuse. JF - Psychiatric services (Washington, D.C.) AU - Tiet, Quyen Q AU - Finney, John W AU - Moos, Rudolf H AD - Center for Health Care Evaluation, Department of Veterans Affairs Palo Alto Health Care System, Menlo Park, California 94025, USA. quyen.tiet@va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 107 EP - 113 VL - 57 IS - 1 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - Severity of Illness Index KW - Demography KW - Humans KW - Surveys and Questionnaires KW - Middle Aged KW - United States -- epidemiology KW - Time Factors KW - Sex Distribution KW - Male KW - Female KW - Prevalence KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Violence -- statistics & numerical data KW - Stress Disorders, Post-Traumatic -- therapy KW - Suicide, Attempted -- psychology KW - Veterans -- psychology KW - Mental Health Services -- utilization KW - Substance-Related Disorders -- diagnosis KW - Substance-Related Disorders -- therapy KW - Sex Offenses -- psychology KW - Sex Offenses -- statistics & numerical data KW - Veterans -- statistics & numerical data KW - Patient Acceptance of Health Care KW - Suicide, Attempted -- statistics & numerical data KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Violence -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67613800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Recent+sexual+abuse%2C+physical+abuse%2C+and+suicide+attempts+among+male+veterans+seeking+psychiatric+treatment.&rft.au=Tiet%2C+Quyen+Q%3BFinney%2C+John+W%3BMoos%2C+Rudolf+H&rft.aulast=Tiet&rft.aufirst=Quyen&rft.date=2006-01-01&rft.volume=57&rft.issue=1&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-15 N1 - Date created - 2006-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quality of care for substance use disorders in patients with serious mental illness. AN - 67590697; 16377454 AB - We assessed the quality of care for substance use disorders (SUDs) among 8,083 patients diagnosed with serious mental illness from the VA mid-Atlantic region. Using data from the National Patient Care Database (2001-2002), we assessed the percentage of patients receiving a diagnosis of SUD, percentage beginning SUD treatment 14 days or earlier after diagnosis, and percentage receiving continued SUD care 30 days or less. Overall, 1,559 (19.3%) were diagnosed with an SUD. Of the 1,559, 966 (62.0%) initiated treatment and 847 (54.3%) received continued care. Although patients diagnosed with bipolar disorder were more likely to receive a diagnosis of SUD than those diagnosed with schizophrenia or schizoaffective disorder (22.7%, 18.9%, and 17.7%, respectively; chi(2) = 26.02, df = 2, p < .001), they were less likely to initiate (49.1%, 70.7%, and 68.6%, respectively; chi(2) = 59.29, df = 2, p < .001) or continue treatment (39.9%, 63.2%, and 62.2%, respectively; chi(2) = 72.25, df = 2, p <. 001). Greater efforts are needed to diagnose and treat SUDs in patients with serious mental illness, particularly for those with bipolar disorder. JF - Journal of substance abuse treatment AU - Kilbourne, Amy M AU - Salloum, Ihsan AU - Dausey, David AU - Cornelius, Jack R AU - Conigliaro, Joseph AU - Xu, Xiangyan AU - Pincus, Harold Alan AD - VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA. amy.kilbourne@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 73 EP - 77 VL - 30 IS - 1 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Severity of Illness Index KW - Humans KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - Aged KW - Middle Aged KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - Quality of Health Care -- standards KW - Mental Disorders -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67590697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Quality+of+care+for+substance+use+disorders+in+patients+with+serious+mental+illness.&rft.au=Kilbourne%2C+Amy+M%3BSalloum%2C+Ihsan%3BDausey%2C+David%3BCornelius%2C+Jack+R%3BConigliaro%2C+Joseph%3BXu%2C+Xiangyan%3BPincus%2C+Harold+Alan&rft.aulast=Kilbourne&rft.aufirst=Amy&rft.date=2006-01-01&rft.volume=30&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2005-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic multisymptom illness complex in Gulf War I veterans 10 years later. AN - 67585910; 16293719 AB - Prior research has demonstrated that shortly after the 1991 Gulf War (Gulf War I), chronic multisymptom illness (CMI) was more common among deployed veterans than among nondeployed veterans. The aims of the current study were to determine the prevalence of CMI among deployed and nondeployed veterans 10 years after Gulf War I, compare the distribution of comorbid conditions, and identify prewar factors associated with CMI. Cross-sectional data collected from 1,061 deployed veterans and 1,128 nondeployed veterans examined between 1999 and 2001 were analyzed. CMI prevalence was 28.9% among deployed veterans and 15.8% among nondeployed veterans (odds ratio = 2.16, 95% confidence interval: 1.61, 2.90). Deployed and nondeployed veterans with CMI had similarly poorer quality-of-life measures and higher prevalences of symptom-based medical conditions, metabolic syndrome, and psychiatric disorders. Diagnoses of prewar anxiety disorders (not related to post-traumatic stress disorder) and depression were associated with CMI among both deployed and nondeployed veterans. Nicotine dependence and veteran-reported physician-diagnosed infectious mononucleosis were associated with CMI among deployed veterans, and migraine headaches and gastritis were associated with CMI among nondeployed veterans. CMI continues to be substantially more prevalent among deployed veterans than among nondeployed veterans 10 years after Gulf War I, but it manifests similarly in both groups. It is likely to be a common, persistent problem among veterans returning from the current Gulf War. JF - American journal of epidemiology AU - Blanchard, Melvin S AU - Eisen, Seth A AU - Alpern, Renee AU - Karlinsky, Joel AU - Toomey, Rosemary AU - Reda, Domenic J AU - Murphy, Frances M AU - Jackson, Leila W AU - Kang, Han K AD - Medical and Research Services, St. Louis Veterans Affairs Medical Center, St. Louis, MO 63106, USA. melvin.blanchard@med.va.gov Y1 - 2006/01/01/ PY - 2006 DA - 2006 Jan 01 SP - 66 EP - 75 VL - 163 IS - 1 SN - 0002-9262, 0002-9262 KW - Index Medicus KW - Humans KW - Quality of Life KW - Comorbidity KW - Risk Assessment KW - Cross-Sectional Studies KW - Risk Factors KW - Adult KW - Chronic Disease KW - Middle Aged KW - United States -- epidemiology KW - Time Factors KW - Female KW - Male KW - Prevalence KW - Sickness Impact Profile KW - Veterans -- statistics & numerical data KW - Gulf War KW - Persian Gulf Syndrome -- epidemiology KW - Military Personnel -- statistics & numerical data KW - Persian Gulf Syndrome -- physiopathology KW - Military Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67585910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Chronic+multisymptom+illness+complex+in+Gulf+War+I+veterans+10+years+later.&rft.au=Blanchard%2C+Melvin+S%3BEisen%2C+Seth+A%3BAlpern%2C+Renee%3BKarlinsky%2C+Joel%3BToomey%2C+Rosemary%3BReda%2C+Domenic+J%3BMurphy%2C+Frances+M%3BJackson%2C+Leila+W%3BKang%2C+Han+K&rft.aulast=Blanchard&rft.aufirst=Melvin&rft.date=2006-01-01&rft.volume=163&rft.issue=1&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-16 N1 - Date created - 2005-12-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Epidemiol. 2006 Oct 1;164(7):708-9; author reply 709-10 [16943267] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Pharmacological and Psychological Treatment of Personality Disorders -- From Neurobiology to Treatment Strategies AN - 61413907; 200703385 AB - A dimensional approach to the study of personality disorders proposes that abnormalities in cognitive control, affective instability, impulsivity/aggression & anxiety, are biologically mediated & range from Axis I disorders to more chronic, milder disturbances of personality. This approach provides a framework for investigating the neurobiological underpinnings of personality disorders & possible therapeutic interventions. The interplay between biological temperament & environmental adversity contribute to personality dysfunction & this idea is reflected in treatment approaches such as dialectical behavioral therapy. The current neurobiology & specific treatments, both pharmacological & psychosocial, are reviewed. Connections between the biological underpinnings & treatment strategies are presented. Despite the numerous limitations in the treatment literature, therapeutic improvement is possible for individuals with personality disorders. Tables, References. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Family Psychotherapy AU - Goodman, Marianne AU - Vail, Lucia AU - West, Sara AU - New, Antonia AU - Siever, Larry AD - Mount Sinai Mood & Personality Disorder Research Program, Bronx VAMC, NY marianne.goodman@med.va.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 53 EP - 81 PB - Haworth Press, Binghamton NY VL - 17 IS - 3-4 SN - 0897-5353, 0897-5353 KW - Personality disorder, neurobiology, treatment, pharmacology, psychotherapy, dialectical, behavioral therapy KW - Biological Factors KW - Behavior Modification KW - Environmental Factors KW - Treatment Methods KW - Personality Disorders KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61413907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Psychotherapy&rft.atitle=The+Pharmacological+and+Psychological+Treatment+of+Personality+Disorders+--+From+Neurobiology+to+Treatment+Strategies&rft.au=Goodman%2C+Marianne%3BVail%2C+Lucia%3BWest%2C+Sara%3BNew%2C+Antonia%3BSiever%2C+Larry&rft.aulast=Goodman&rft.aufirst=Marianne&rft.date=2006-01-01&rft.volume=17&rft.issue=3-4&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Psychotherapy&rft.issn=08975353&rft_id=info:doi/10.1300%2FJ085v17n03_04 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-08-01 N1 - Number of references - 122 N1 - Last updated - 2016-09-28 N1 - CODEN - JFAPEF N1 - SubjectsTermNotLitGenreText - Personality Disorders; Biological Factors; Environmental Factors; Treatment Methods; Behavior Modification DO - http://dx.doi.org/10.1300/J085v17n03_04 ER - TY - JOUR T1 - Patients' and Healthcare Providers' Understandings of Life-Sustaining Treatment: Are Perceptions of Goals Shared or Divergent? AN - 61350560; 200604766 AB - In this cross-sectional qualitative study, researchers performed in-depth, semistructured interviews with 30 pairs of patients & their primary care providers in an outpatient clinic of a large, urban Veterans Affairs (VA) medical center in the United States. During audiotaped interviews to assess their understanding of advance directive concepts, participants were asked what "life-sustaining treatment" means to them & why they think of it in the way they do. The findings indicate that patients & providers in the United States tend to view & discuss life-sustaining treatment in terms of four goals for end-of-life care: (1) extending the length of life, (2) improving the quality of life, (3) maintaining or improving specific biological functions, & (4) assisting the body for a temporary period of time. Patients thought providers were more concerned with extending the length of life than with quality-based outcomes, & patients often discussed life-sustaining treatment as acceptable means for short-term but not long-term use. Many providers indicated that they struggle with conflicting quality-based & physiologic care goals. The findings highlight the importance of eliciting patient preferences not only for specific types of treatment, such as cardiopulmonary resuscitation, but also for end-of-life care goals or desired health-related outcomes, such as maximizing the quantity of life. The findings also suggest that advance directives & patient-provider discussions that focus on acceptable health states & valued life activities may be better suited to patients' end-of-life care goals than those that focus on specific medical interventions. References. [Copyright 2005 Elsevier Ltd.] JF - Social Science & Medicine AU - Rodriguez, Keri L AU - Young, Amanda J AD - VA Pittsburgh Health Care System, Center Health Equity Research & Promotion, PA keri.rodriguez@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 125 EP - 133 PB - Elsevier Science, Amsterdam The Netherlands VL - 62 IS - 1 SN - 0277-9536, 0277-9536 KW - USA KW - End-of-life care KW - Life-sustaining treatment KW - Advance care planning KW - Healthcare preferences KW - Qualitative research KW - Veterans KW - Outpatients KW - Health Professions KW - Quality of Health Care KW - Long Term Care KW - Palliative Care KW - United States of America KW - Medical Decision Making KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61350560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Patients%27+and+Healthcare+Providers%27+Understandings+of+Life-Sustaining+Treatment%3A+Are+Perceptions+of+Goals+Shared+or+Divergent%3F&rft.au=Rodriguez%2C+Keri+L%3BYoung%2C+Amanda+J&rft.aulast=Rodriguez&rft.aufirst=Keri&rft.date=2006-01-01&rft.volume=62&rft.issue=1&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2005.05.023 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - United States of America; Health Professions; Medical Decision Making; Palliative Care; Long Term Care; Quality of Health Care; Outpatients DO - http://dx.doi.org/10.1016/j.socscimed.2005.05.023 ER - TY - JOUR T1 - Assets in Intrahousehold Bargaining among Women Workers in Colombia's Cut-Flower Industry AN - 60010782; 200619758 AB - Drawing on ethnographic & survey data, this article examines the diverse ways in which land & home ownership, wage income, & social capital combine to structure the alternatives of women workers in the cut-flower industry of rural Colombia. Most of these workers live in traditional male-dominated households where domestic abuse is prevalent. Data showing rates of property ownership by gender are presented, & the barriers & facilitators to property ownership by gender among agricultural wage-workers are analyzed. Property ownership is acquired largely through inheritance or purchase, which is influenced by social capital & the historical nature of relationships with large landowners. Women's household bargaining strategies rely on a combination of assets: kin networks; labor-related networks; & physical, financial, & individual assets. The author argues that the social capital of individuals, including their labor, kin, & solidarity networks, is key to an understanding of both property acquisition & intrahousehold bargaining processes. Tables, References. Adapted from the source document. JF - Feminist Economics AU - Friedemann-Sanchez, Greta AD - Center Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, MN Greta.Friedemann-Sanchez@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 247 EP - 269 PB - Taylor & Francis, Abingdon UK VL - 12 IS - 1-2 SN - 1354-5701, 1354-5701 KW - Social capital, property, agricultural labor, domestic violence, non-traditional exports, rural Colombia KW - Working Women KW - Households KW - Wages KW - Agricultural Workers KW - Ownership KW - Colombia KW - Cultural Capital KW - article KW - 0621: complex organization; jobs, work organization, workplaces, & unions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60010782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Feminist+Economics&rft.atitle=Assets+in+Intrahousehold+Bargaining+among+Women+Workers+in+Colombia%27s+Cut-Flower+Industry&rft.au=Friedemann-Sanchez%2C+Greta&rft.aulast=Friedemann-Sanchez&rft.aufirst=Greta&rft.date=2006-01-01&rft.volume=12&rft.issue=1-2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Feminist+Economics&rft.issn=13545701&rft_id=info:doi/10.1080%2F13545700500508551 LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Number of references - 39 N1 - Last updated - 2016-09-28 N1 - CODEN - FEECFE N1 - SubjectsTermNotLitGenreText - Households; Ownership; Wages; Cultural Capital; Working Women; Colombia; Agricultural Workers DO - http://dx.doi.org/10.1080/13545700500508551 ER - TY - JOUR T1 - Patients' and Healthcare Providers' Understandings of Life-Sustaining Treatment: Are Perceptions of Goals Shared or Divergent? AN - 60005450; 200620667 AB - In this cross-sectional qualitative study, researchers performed in-depth, semistructured interviews with 30 pairs of patients & their primary care providers in an outpatient clinic of a large, urban Veterans Affairs (VA) medical center in the United States. During audiotaped interviews to assess their understanding of advance directive concepts, participants were asked what "life-sustaining treatment" means to them & why they think of it in the way they do. The findings indicate that patients & providers in the United States tend to view & discuss life-sustaining treatment in terms of four goals for end-of-life care: (1) extending the length of life, (2) improving the quality of life, (3) maintaining or improving specific biological functions, & (4) assisting the body for a temporary period of time. Patients thought providers were more concerned with extending the length of life than with quality-based outcomes, & patients often discussed life-sustaining treatment as acceptable means for short-term but not long-term use. Many providers indicated that they struggle with conflicting quality-based & physiologic care goals. The findings highlight the importance of eliciting patient preferences not only for specific types of treatment, such as cardiopulmonary resuscitation, but also for end-of-life care goals or desired health-related outcomes, such as maximizing the quantity of life. The findings also suggest that advance directives & patient-provider discussions that focus on acceptable health states & valued life activities may be better suited to patients' end-of-life care goals than those that focus on specific medical interventions. References. [Copyright 2005 Elsevier Ltd.] JF - Social Science & Medicine AU - Rodriguez, Keri L AU - Young, Amanda J AD - VA Pittsburgh Health Care System, Center Health Equity Research & Promotion, PA keri.rodriguez@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 125 EP - 133 PB - Elsevier Science, Amsterdam The Netherlands VL - 62 IS - 1 SN - 0277-9536, 0277-9536 KW - USA KW - End-of-life care KW - Life-sustaining treatment KW - Advance care planning KW - Healthcare preferences KW - Qualitative research KW - Veterans KW - Outpatients KW - Health Professions KW - Quality of Health Care KW - Long Term Care KW - Palliative Care KW - United States of America KW - Medical Decision Making KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60005450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Patients%27+and+Healthcare+Providers%27+Understandings+of+Life-Sustaining+Treatment%3A+Are+Perceptions+of+Goals+Shared+or+Divergent%3F&rft.au=Rodriguez%2C+Keri+L%3BYoung%2C+Amanda+J&rft.aulast=Rodriguez&rft.aufirst=Keri&rft.date=2006-01-01&rft.volume=62&rft.issue=1&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2005.05.023 LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - United States of America; Health Professions; Medical Decision Making; Palliative Care; Long Term Care; Quality of Health Care; Outpatients DO - http://dx.doi.org/10.1016/j.socscimed.2005.05.023 ER - TY - JOUR T1 - Sanctification of Parenting: Links to Corporal Punishment and Parental Warmth Among Biblically Conservative and Liberal Mothers AN - 57219734; 200715821 AB - A growing body of research has examined links between religious beliefs and parenting practices. This study used the theoretical construct of sanctification to examine the degree to which parenting holds spiritual significance and meaning for parents and whether sanctification is related to parenting behaviors. Seventy-four mothers completed questionnaires measuring sanctification of the parenting role, a biblical conservatism scale, and measures of parenting practices. Greater sanctification of parenting was associated with less use of verbal aggression and, to some extent, increased parental consistency. Biblical conservatism moderated the link between sanctification and (a) use of corporal punishment and (b) positive parent-child interactions. Specifically, greater sanctification of parenting was tied to decreased corporal punishment by mothers with liberal biblical beliefs but related to more use of corporal punishment among conservative mothers, greater sanctification was tied to increased positive mother-child interactions by mothers with conservative biblical views but did not alter the uniformly high rates of positivity reported by liberal mothers. Findings are integrated with theoretical work on sanctification and existing empirical research on religion and parenting. Adapted from the source document. JF - The International Journal for the Psychology of Religion AU - Murray-Swank, Aaron AU - Mahoney, Annette AU - Pargament, Kenneth I AD - VA Maryland Healthcare System, MIRECC, Baltimore, MD aaron.murray-swank@med.va.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 271 EP - 287 PB - Lawrence Erlbaum, Mahwah NJ VL - 16 IS - 4 SN - 1050-8619, 1050-8619 KW - Parenting style KW - Religious aspects KW - Corporal punishment KW - Religious beliefs KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57219734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+Journal+for+the+Psychology+of+Religion&rft.atitle=Sanctification+of+Parenting%3A+Links+to+Corporal+Punishment+and+Parental+Warmth+Among+Biblically+Conservative+and+Liberal+Mothers&rft.au=Murray-Swank%2C+Aaron%3BMahoney%2C+Annette%3BPargament%2C+Kenneth+I&rft.aulast=Murray-Swank&rft.aufirst=Aaron&rft.date=2006-01-01&rft.volume=16&rft.issue=4&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=The+International+Journal+for+the+Psychology+of+Religion&rft.issn=10508619&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-08-28 N1 - Last updated - 2016-09-27 N1 - CODEN - IPRLEB N1 - SubjectsTermNotLitGenreText - Religious beliefs; Parenting style; Corporal punishment; Religious aspects ER - TY - JOUR T1 - Patients' and Healthcare Providers' Understandings of Life-Sustaining Treatment: Are Perceptions of Goals Shared or Divergent? AN - 57209378; 200613382 AB - In this cross-sectional qualitative study, researchers performed in-depth, semistructured interviews with 30 pairs of patients & their primary care providers in an outpatient clinic of a large, urban Veterans Affairs (VA) medical center in the United States. During audiotaped interviews to assess their understanding of advance directive concepts, participants were asked what "life-sustaining treatment" means to them & why they think of it in the way they do. The findings indicate that patients & providers in the United States tend to view & discuss life-sustaining treatment in terms of four goals for end-of-life care: (1) extending the length of life, (2) improving the quality of life, (3) maintaining or improving specific biological functions, & (4) assisting the body for a temporary period of time. Patients thought providers were more concerned with extending the length of life than with quality-based outcomes, & patients often discussed life-sustaining treatment as acceptable means for short-term but not long-term use. Many providers indicated that they struggle with conflicting quality-based & physiologic care goals. The findings highlight the importance of eliciting patient preferences not only for specific types of treatment, such as cardiopulmonary resuscitation, but also for end-of-life care goals or desired health-related outcomes, such as maximizing the quantity of life. The findings also suggest that advance directives & patient-provider discussions that focus on acceptable health states & valued life activities may be better suited to patients' end-of-life care goals than those that focus on specific medical interventions. 31 References. [Copyright 2005 Elsevier Ltd.] JF - Social Science & Medicine AU - Rodriguez, Keri L AU - Young, Amanda J AD - VA Pittsburgh Health Care System, Center Health Equity Research & Promotion, PA keri.rodriguez@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 125 EP - 133 PB - Elsevier Science, Amsterdam The Netherlands VL - 62 IS - 1 SN - 0277-9536, 0277-9536 KW - USA KW - End-of-life care KW - Life-sustaining treatment KW - Advance care planning KW - Healthcare preferences KW - Qualitative research KW - Veterans KW - Quality of care KW - Life sustaining treatment KW - End of life decisions KW - Palliative care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57209378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Patients%27+and+Healthcare+Providers%27+Understandings+of+Life-Sustaining+Treatment%3A+Are+Perceptions+of+Goals+Shared+or+Divergent%3F&rft.au=Rodriguez%2C+Keri+L%3BYoung%2C+Amanda+J&rft.aulast=Rodriguez&rft.aufirst=Keri&rft.date=2006-01-01&rft.volume=62&rft.issue=1&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - End of life decisions; Life sustaining treatment; Palliative care; Quality of care DO - http://dx.doi.org/10.1016/j.socscimed.2005.05.023 ER - TY - JOUR T1 - Under-Reporting of Work-Related Musculoskeletal Disorders in the Veterans Administration AN - 57097353; 200704396 AB - Purpose: Work-related musculoskeletal disorders following patient contact represent a major concern for health care workers. Unfortunately, research & prevention have been hampered by difficulties ascertaining true prevalence rates owing to under-reporting of these injuries. The purpose of this study is to determine the predictors for under-reporting work-related musculoskeletal injuries & their reasons. Design/methodology/approach: Multivariate analysis using data obtained in a survey of Veterans Administration employees in the USA was used to determine underreporting patterns among registered nurses, licensed practical nurses & nursing assistants. Focus groups among health care workers were conducted at one of the largest Veterans Administration hospitals to determine reasons for under-reporting. Findings: A significant number of workers reported work-related musculoskeletal pain, which was not reported as an injury but required rescheduling work such as changing shifts & taking sick leave to recuperate. The findings indicate that older health care workers & those with longer service were less likely to report as were those working in the evening & night shifts. Hispanic workers & personnel who had repetitive injuries were prone to under-reporting, as were workers in places that lack proper equipment to move & handle patients. Reasons for under-reporting include the time involved, peer pressure not to report & frustration with workers' compensation procedures. Originality/value: This study provides insights into under-reporting musculoskeletal injuries in a major US government organization. The research indicates that current reporting procedures appear to be overtly cumbersome in time & effort. More flexible work assignments are needed to cover staff shortfalls owing to injuries. Health education on the detrimental long-term effects of ergonomic injuries & the need for prompt attention to injuries should prove useful in improving rates of reporting. Tables, References. Adapted from the source document. JF - International Journal of Health Care Quality Assurance AU - Siddharthan, Kris AU - Hodgson, Michael AU - Rosenberg, Deborah AU - Haiduven, Donna AU - Nelson, Audrey AD - Patient Safety Center Inquiry, James A. Haley Veterans Administration Medical Center, Tampa, FL kris.siddharthan@med.va.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 463 EP - 476 PB - Emerald Group Publishing Ltd., Bradford UK VL - 19 IS - 6-7 SN - 0952-6862, 0952-6862 KW - Injuries KW - Employees KW - Health services sector, Regression analysis, Focus groups, United States of America KW - Health Services KW - Musculoskeletal Diseases KW - Industrial Accidents KW - Underreporting KW - Health Professional-Patient Interactions KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57097353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Health+Care+Quality+Assurance&rft.atitle=Under-Reporting+of+Work-Related+Musculoskeletal+Disorders+in+the+Veterans+Administration&rft.au=Siddharthan%2C+Kris%3BHodgson%2C+Michael%3BRosenberg%2C+Deborah%3BHaiduven%2C+Donna%3BNelson%2C+Audrey&rft.aulast=Siddharthan&rft.aufirst=Kris&rft.date=2006-01-01&rft.volume=19&rft.issue=6-7&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Health+Care+Quality+Assurance&rft.issn=09526862&rft_id=info:doi/10.1108%2F09526860610686971 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-02-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Musculoskeletal Diseases; Underreporting; Health Services; Health Professional-Patient Interactions; Industrial Accidents DO - http://dx.doi.org/10.1108/09526860610686971 ER - TY - JOUR T1 - Physical and Mental Health and Access to Care among Nonmetropolitan Veterans Health Administration Patients Younger than 65 Years AN - 57071758; 200619317 AB - Context: The 4.5 million military veterans treated by the Veterans Health Administration (VA) are believed to experience poorer physical & mental health than nonveterans. Furthermore, nonmetropolitan residents have less access to medical services, whether or not they are veterans in VA care. A direct comparison of metropolitan & nonmetropolitan veterans & nonveterans on a national health survey has not been reported, so it is not known whether nonmetropolitan VA patients experience similar medical need or access as other non metropolitan residents. Purpose: We sought to compare the perceptions of health status & access to care among metropolitan & nonmetropolitan veterans in VA care, other veterans, & nonveterans in a large national sample surveyed under the same conditions. Methods: Male respondents to the 2000 Behavioral Risk Factor Surveillance System health survey were divided into veterans or nonveterans, VA users or nonusers, metropolitan or nonmetropolitan residents, & I of 3 age groups (18-44, 45-64, & 65+). Responses to questions about current health status, health coverage, & access to care were submitted to chi -square analyses or analyses of variance, using SUDAAN software to compute survey error variance. Findings: Nonmetropolitan VA patients younger than 65 years consistently reported the worst physical & mental health status & reduced access to care. Conclusions: VA can anticipate increasing demand for mental & physical health care among rural veterans younger than 65 years. Figures, References. Adapted from the source document. JF - The Journal of Rural Health AU - West, Alan AU - Weeks, William B AD - Center Rural Health Studies, VA Medical Center, White River Junction, VT alan.west@med.va.gov Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 9 EP - 16 PB - National Rural Health Association, Kansas City MO VL - 22 IS - 1 SN - 0890-765X, 0890-765X KW - Veterans KW - Health Care KW - Mental Health Care KW - Health KW - Access KW - Metropolitan Areas KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57071758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health&rft.atitle=Physical+and+Mental+Health+and+Access+to+Care+among+Nonmetropolitan+Veterans+Health+Administration+Patients+Younger+than+65+Years&rft.au=West%2C+Alan%3BWeeks%2C+William+B&rft.aulast=West&rft.aufirst=Alan&rft.date=2006-01-01&rft.volume=22&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health&rft.issn=0890765X&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-29 N1 - Last updated - 2016-09-27 N1 - CODEN - JRHEEX N1 - SubjectsTermNotLitGenreText - Veterans; Access; Health; Health Care; Mental Health Care; Metropolitan Areas ER - TY - JOUR T1 - "Stereotypic" Delusional Offending AN - 57044356; 200614733 AB - Some patients with serious mental illness appear to respond violently to the same delusional content throughout the course of their illness. Anecdotal, empirical, & theoretical evidence is presented establishing the premise of "stereotypic" delusional offending. A method for measuring the similarity of two delusions separated in time also is presented. An empirical focus on stereotypic delusional offending may help identify more accurately persons at risk for violence & those at risk for becoming targets of violence. It also may provide a better understanding of successful treatment of outpatient violence & conceivably could inform the ongoing debate on involuntary outpatient commitment laws. Among the major issues of this debate in the United States are the potential benefits of a forced medication provision. One rationale for such a provision may be found in the treatment response of seriously mentally ill outpatients whose violent behavior appears inescapably tied to their persistent or recurrent delusions. 2 Tables, 3 Figures, 37 References. [Copyright 2006 John Wiley and Sons, Ltd.] JF - Behavioral Sciences & the Law AU - Junginger, John AD - Veterans' Administration Maryland Health Care System, U Maryland, School Medicine, Baltimore john.junginger@med.va.gov Y1 - 2006///0, PY - 2006 DA - 0, 2006 SP - 295 EP - 311 PB - John Wiley & Sons, Chichester UK VL - 24 IS - 3 SN - 0735-3936, 0735-3936 KW - Delusions KW - Violence KW - Risks KW - Offending KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57044356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Sciences+%26+the+Law&rft.atitle=%22Stereotypic%22+Delusional+Offending&rft.au=Junginger%2C+John&rft.aulast=Junginger&rft.aufirst=John&rft.date=2006-01-01&rft.volume=24&rft.issue=3&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Behavioral+Sciences+%26+the+Law&rft.issn=07353936&rft_id=info:doi/10.1002%2Fbsl.682 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-10-02 N1 - Last updated - 2016-09-27 N1 - CODEN - BSLADR N1 - SubjectsTermNotLitGenreText - Delusions; Offending; Violence; Risks DO - http://dx.doi.org/10.1002/bsl.682 ER - TY - JOUR T1 - Gene therapy, cell transplantation and stroke AN - 21210221; 11197567 AB - The use of neuroteratocarcinoma cells for transplantation therapy in stroke has emerged as a strategy for cell replacement therapy that has begun its transition from basic science laboratories to a clinical setting. Procurement logistics and novel neuroprotective functions associated with these cells allow neuroteratocarcinoma cells to serve as efficacious alternatives to using fetal cells as donor cell grafts for stroke therapy, although the optimal transplantation regimen must still be determined. In particular, the limitations of current stroke treatments and management reveal an urgent need to examine the efficacy of experimental treatments, such as neural transplantation, in order to develop better treatment therapies. This chapter will discuss the characteristics of NT2N cells, the role of the host brain microenvironment, the need for more rigorous laboratory research and clinical trials for the intracerebral transplantation of NT2N cells in stroke, the mechanisms underlying the grafts' beneficial effects, and the need for immunosuppression. This chapter will highlight some of the most recent findings regarding NT2N cells. JF - Frontiers in Bioscience AU - Borlongan, C V AU - Fournier, C AU - Stahl, CE AU - Yu, G AU - Xu, L AU - Matsukawa, N AU - Newman, M AU - Yasuhara, T AU - Hara, K AU - Hess, D C AU - Sanberg, PR AD - Department of Neurology, Medical College of Georgia, Augusta Veterans Administration Medical Center, Augusta GA 30912, USA Y1 - 2006 PY - 2006 DA - 2006 SP - 1090 EP - 1100 VL - 11 SN - 1093-9946, 1093-9946 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Transplantation KW - Gene therapy KW - Stroke KW - Brain KW - Microenvironments KW - Neuroprotection KW - Clinical trials KW - Fetuses KW - Immunosuppression KW - W 30905:Medical Applications KW - N3 11023:Neurogenetics KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21210221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+Bioscience&rft.atitle=Gene+therapy%2C+cell+transplantation+and+stroke&rft.au=Borlongan%2C+C+V%3BFournier%2C+C%3BStahl%2C+CE%3BYu%2C+G%3BXu%2C+L%3BMatsukawa%2C+N%3BNewman%2C+M%3BYasuhara%2C+T%3BHara%2C+K%3BHess%2C+D+C%3BSanberg%2C+PR&rft.aulast=Borlongan&rft.aufirst=C&rft.date=2006-01-01&rft.volume=11&rft.issue=&rft.spage=1090&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+Bioscience&rft.issn=10939946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Transplantation; Gene therapy; Stroke; Brain; Microenvironments; Neuroprotection; Clinical trials; Fetuses; Immunosuppression ER - TY - JOUR T1 - Sun exposure, sexual behavior and uterine cervical human papilloma virus AN - 20962731; 6669418 AB - We have previously observed marked seasonal fluctuations in the frequency of cervical smears positive for human papilloma virus (HPV) in a series of smears obtained in Holland, with a peak in the summer months, especially August. Here, we tested two possible mechanisms that might underlie this summer peak: (1) enhanced transmission of HPV due to increased seasonal sexual activity, or (2) suppression of immunity due to summertime population exposure to solar ultraviolet (UV) radiation. Data derived from a continuous series of >900,000 independent cervical smears obtained from 1983 to 1998 were assessed for histopathologic epithelial changes pathognomonic of HPV. The rate of HPV positivity was then compared to both the rate of sexual activity (using conception frequency as a readily available surrogate) as well as yearly and monthly fluctuations in solar-UV fluency. The rate of HPV positivity was found to be twice as high during the summer months, with a peak in August corresponding with maximal UV fluency. Furthermore, over these 16 consecutive years of continuous observation, maximum HPV detection rate and maximum UV fluency are positively correlated (r=0.59, P<0.01); the sunnier the year, the greater the rate of HPV. Likewise, there is a positive correlation of the monthly UV fluency, and monthly HPV discovery rate (r=0.16, P<0.03). In contrast, conception frequency (and, presumably, population sexual HPV transmission) was maximal near the vernal equinox, with relatively modest (<10%) seasonal fluctuation, i.e., not fully explaining this prominent August peak in HPV discovery. There is a clear relationship between the detection of HPV-positive cervical smears and sunlight exposure. We speculate that the well-known phenomenon of UV-mediated suppression of immune surveillance may be causally related to this unusual increase in cytologically defined active HPV infections during the summer months in northern countries such as Holland. Confirming this relationship elsewhere may be important, because whatever the risk conferred by sunlight is, in principle, behaviorally avoidable. JF - International Journal of Biometeorology AU - Hrushesky, WJM AU - Sothern, R B AU - Rietveld, W J AU - Du-Quiton, J AU - Boon, ME AD - Epidemiology and Biostatistics, Norman J. Arnold School of Public Health, University of South Carolina School of Medicine, Columbia, SC, USA, william.hrushesky@va.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 167 EP - 173 VL - 50 IS - 3 SN - 0020-7128, 0020-7128 KW - Virology & AIDS Abstracts; Risk Abstracts KW - sexual behavior KW - Uterus KW - Data processing KW - disease transmission KW - Immunity KW - sunlight KW - Infection KW - Sexual behavior KW - sun KW - Disease transmission KW - Sulfur dioxide KW - U.V. radiation KW - Immunosurveillance KW - Ultraviolet radiation KW - Sun KW - infection KW - summer KW - Sunlight KW - Cervix KW - Seasonal variations KW - Human papillomavirus KW - V 22350:Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20962731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=Expression+of+the+proto-oncogene+eIF4E+in+inflammation+of+the+oral+cavity.&rft.au=Chandy%2C+Binoy%3BAbreo%2C+Fleurette%3BNassar%2C+Raja%3BStucker%2C+Fred+J%3BNathan%2C+Cherie-Ann&rft.aulast=Chandy&rft.aufirst=Binoy&rft.date=2002-03-01&rft.volume=126&rft.issue=3&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Uterus; Data processing; U.V. radiation; Immunosurveillance; Sun; Sunlight; Immunity; Infection; Cervix; Sexual behavior; Disease transmission; sexual behavior; Sulfur dioxide; disease transmission; Ultraviolet radiation; infection; summer; sunlight; Seasonal variations; sun; Human papillomavirus ER - TY - JOUR T1 - Gastrointestinal endoscopic findings in men with unexplained anemia and low normal ferritin values AN - 20862147; 6837822 AB - Background: Most practice guidelines recommend endoscopic evaluation of the gastrointestinal (GI) tract in men and postmenopausal women with anemia and a serum ferritin less than 20-40 ng/ml. The diagnostic yield of endoscopy in patients with anemia, no GI symptoms or signs, and low normal ferritin is not known. Objective: The aim of this study was to investigate the yield of upper and lower GI endoscopic evaluations in anemic patients with ferritin levels between 40 and 100 ng/ml. Design: A retrospective review of patients' charts was conducted. Subjects and methods: Patients at the Veterans Affairs Connecticut Healthcare System who underwent GI endoscopic evaluation for the sole indication of anemia and ferritin in the low normal range (40-100 ng/ml) were included in this study. Measurements: Incidence of pathology of the upper and lower GI tract was determined. Results: We identified 54 male patients who had a ferritin level of 40-100 ng/ml and no GI symptoms or known GI bleeding. Upper GI findings (malignancy, peptic ulcers, Helicobacter pylori gastritis, arteriovenous malformations) were found in 14/47 cases (30%). Lower gastrointestinal findings, including large tubular adenomas and arteriovenous malformation, were identified in 3/53 cases (6.7%). Conclusion: Our study supports GI endoscopy in anemic patients with ferritin between 40 and 100 ng/ml, even in the absence of GI symptoms or documented bleeding. Am. J. Hematol. 81:324-327, 2006. JF - American Journal of Hematology AU - Wang, Sa A AU - Fadare, Oluwole AU - Nagar, Anil AU - Shafi, Nelofar Q AU - Rose, Michal G AD - Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts, Michal.Rose@va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 324 EP - 327 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 81 IS - 5 SN - 0361-8609, 0361-8609 KW - Microbiology Abstracts B: Bacteriology KW - iron deficiency anemia ferritin endoscopy KW - Helicobacter pylori KW - Malignancy KW - Post-menopause KW - Anemia KW - Bleeding KW - Ferritin KW - peptic ulcers KW - Gastrointestinal tract KW - Adenoma KW - Gastritis KW - Endoscopy KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20862147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Hematology&rft.atitle=Gastrointestinal+endoscopic+findings+in+men+with+unexplained+anemia+and+low+normal+ferritin+values&rft.au=Wang%2C+Sa+A%3BFadare%2C+Oluwole%3BNagar%2C+Anil%3BShafi%2C+Nelofar+Q%3BRose%2C+Michal+G&rft.aulast=Wang&rft.aufirst=Sa&rft.date=2006-01-01&rft.volume=81&rft.issue=5&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Hematology&rft.issn=03618609&rft_id=info:doi/10.1002%2Fajh.20613 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Malignancy; Post-menopause; Bleeding; Anemia; peptic ulcers; Ferritin; Gastrointestinal tract; Gastritis; Adenoma; Endoscopy; Helicobacter pylori DO - http://dx.doi.org/10.1002/ajh.20613 ER - TY - JOUR T1 - Laboratory-acquired infections: Are microbiologists at risk? AN - 19710192; 7583399 AB - Exposure of laboratory workers to infectious agents in the clinical microbiology laboratory continues to be an occupational risk. This risk is mitigated by the application of safety guidelines issued by regulatory agencies and professional organizations. The Clinical and Laboratory Standards Institute (fomerly NCCLS) published a guidance document (M29-A3) in 2005 on the risk of transmission of infectious agents in the laboratory, preventative measures to reduce risk, and management of exposure to infectious agents. The key to a safe workplace is employees who are knowledgeable of the routes of transmission of infectious agents in the laboratory setting and apply safety principles and work practices to reduce the risk. JF - Clinical Microbiology Newsletter AU - Sewell, David L AD - Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center and Department of Pathology, Oregon Health and Science University, Portland, Oregon, david.sewell@med.va.gov Y1 - 2006/01// PY - 2006 DA - Jan 2006 SP - 1 EP - 6 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 28 IS - 1 SN - 0196-4399, 0196-4399 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts KW - Risk assessment KW - risk reduction KW - guidelines KW - infection KW - microbiologists KW - Infection KW - Occupational exposure KW - A 01450:Environmental Pollution & Waste Treatment KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19710192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+Newsletter&rft.atitle=Laboratory-acquired+infections%3A+Are+microbiologists+at+risk%3F&rft.au=Sewell%2C+David+L&rft.aulast=Sewell&rft.aufirst=David&rft.date=2006-01-01&rft.volume=28&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+Newsletter&rft.issn=01964399&rft_id=info:doi/10.1016%2Fj.clinmicnews.2005.12.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Infection; Occupational exposure; risk reduction; guidelines; microbiologists; infection DO - http://dx.doi.org/10.1016/j.clinmicnews.2005.12.004 ER - TY - JOUR T1 - Cytokine-containing gelfoam implants at a postsurgical tumor excision site to stimulate local immune reactivity AN - 19443658; 6837541 AB - We previously demonstrated increased numbers of CD34 super(+) progenitor cells in the peripheral blood of tumor bearers. Also demonstrated was the feasibility of chemoattracting these cells by sponge implants containing VEGF. The present study used a murine Lewis lung carcinoma (LLC) model to test if CD34 super(+) cells that are chemoattracted to a tumor excision site can be differentiated in situ into dendritic cells and whether this leads to increased local immune reactivity. After surgically excising established LLC tumors, mice received at the excision site gelatin sponge implants containing VEGF to chemoattract CD34 super(+) cells, and/or GM-CSF plus SCF to induce CD34 super(+) cell differentiation into dendritic cells. In some studies, lysates of GFP-transfected LLC cells (LLC super(GFP)) were also included in the implants as a source of tumor antigen. After 2 weeks, implants and local lymph nodes were removed and analyzed. Implants containing VEGF, GM-CSF/SCF or VEGF/GM-CSF/SCF had a higher proportion of CD34 super(+) cells compared to control implants. However, the number of dendritic cells was higher in implants containing GM-CSF/SCF or VEGF/GM-CSF/SCF than those containing either VEGF or diluent. Regional lymph node from mice containing GM-CSF/SCF or VEGF/GM-CSF/SCF implants showed increased dendritic cell levels. However, when lysates from LLC super(GFP) were added to the implants, the highest proportion of dendritic cells associated with GFP was in lymph nodes of mice containing GM-CSF/SCF implants. Lymph node cells from mice with GM- CSF/SCF or VEGF/GM-CSF/SCF had a higher level of proliferation and IFN-[gamma] secretion in response to in vitro LLC lysate challenge, with the greatest response being from lymph node cells of mice with GM-CSF/SCF implants. These results suggest the feasibility of using GM-CSF/SCF-containing implants to increase dendritic cell levels, uptake of tumor antigens, trafficking to lymph nodes and stimulation of immune reactivity at tumor excision sites with residual tumor. JF - International Journal of Cancer AU - Young, MRita I AD - Department of Research Services, Ralph H. Johnson V.A. Medical Center, Charleston, SC, USA, rita.young@med.va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 133 EP - 138 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 1 SN - 0020-7136, 0020-7136 KW - Biotechnology and Bioengineering Abstracts KW - Vascular endothelial growth factor KW - Lung carcinoma KW - Gelatin KW - Animal models KW - Granulocyte-macrophage colony-stimulating factor KW - Peripheral blood KW - CD34 antigen KW - Tumors KW - Diluents KW - Lymph nodes KW - Differentiation KW - Dendritic cells KW - Stem cells KW - Antigen (tumor-associated) KW - Hemopoiesis KW - Cell proliferation KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19443658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Cytokine-containing+gelfoam+implants+at+a+postsurgical+tumor+excision+site+to+stimulate+local+immune+reactivity&rft.au=Young%2C+MRita+I&rft.aulast=Young&rft.aufirst=MRita&rft.date=2006-01-01&rft.volume=119&rft.issue=1&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.21806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Granulocyte-macrophage colony-stimulating factor; Vascular endothelial growth factor; Tumors; Dendritic cells; Lymph nodes; CD34 antigen; Antigen (tumor-associated); Diluents; Stem cells; Animal models; Peripheral blood; Differentiation; Gelatin; Hemopoiesis; Cell proliferation; Lung carcinoma DO - http://dx.doi.org/10.1002/ijc.21806 ER - TY - JOUR T1 - Beta-Blockade Mitigates Exercise Blood Pressure in Hypertensive Male Patients AN - 17177373; 6820252 AB - The purpose of this study was to determine the antihypertensive agent(s) more likely to mitigate an exaggerated rise in exercise blood pressure (BP) in hypertensive patients. Background An exaggerated rise in exercise BP is associated with increased cardiovascular risk. There are no recommendations for treating such response. Methods Participants were hypertensive men (n = 2,318; age 60 +/- 10 years), undergoing a routine exercise test at the Veterans Affairs Medical Center, Washington, DC. Antihypertensive therapy included angiotensin- converting enzyme inhibitors (n = 437), calcium-channel blockers (n = 223), diuretics (n = 226), and combinations (n = 1,442), beta-blockers alone (n = 201) or in combination with other antihypertensive agents (n = 467), and none (n = 208). Exercise BP, heart rate (HR) and rate-pressure product (RPP) at maximal and submaximal workloads were assessed. Results After adjusting for covariates, patients treated with beta-blockers or beta-blocker-based therapy had significantly lower BP, HR, and RPP at 5 and 7 metabolic equivalents (METs) and peak exercise than those treated with any other antihypertensive agent or combination (p - 0.05). The likelihood of achieving an exercise systolic BP of >=210 mm Hg was 68% lower (odds ratio = 0.32, 96% confidence interval 0.2 to 0.53) in the beta-blocker-based therapy versus other medications. African Americans exhibited higher BP and HR than Caucasians at all exercise workloads regardless of antihypertensive therapy and had over a 90% higher likelihood for an abnormal exercise BP response. This risk was attenuated by 35% with a beta- blocker-based therapy. Conclusions Significantly lower exercise BP, HR, and RPP levels are achieved with beta-blocker-based therapy than with other antihypertensive agents regardless of race. However, BP was better controlled in Caucasians than in African Americans regardless of antihypertensive therapy. Beta-Blockade Mitigates Exercise Blood Pressure in Hypertensive Male Patients Peter Kokkinos, Christina Chrysohoou, Demosthenes Panagiotakos, Puneet Narayan, Michael Greenberg, Steve Singh We assessed 2,318 hypertensive male patients treated with various antihypertensive agents to determine the exercise blood pressure (BP) response. Patients treated with beta-blockers had significantly lower exercise BP than those treated with any other agent or combination. The likelihood of achieving an exercise systolic BP of >=210 mm Hg was also significantly lower on beta-blocker-based therapy compared with any other therapy. Because repetitive exposure to high hemodynamic loads is associated with cardiovascular events, beta-blockade therapy is more likely to protect against excessive and repetitive elevations in BP which may occur during daily bouts of physical exertion in hypertensive patients. JF - Journal of the American College of Cardiology AU - Kokkinos, Peter AU - Chrysohoou, Christina AU - Panagiotakos, Demosthenes AU - Narayan, Puneet AU - Greenberg, Michael AU - Singh, Steve AD - Cardiology Division, Veterans Affairs and Georgetown University Medical Centers, Washington, DC., peter.kokkinos@med.va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 794 EP - 798 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.com] VL - 47 IS - 4 SN - 0735-1097, 0735-1097 KW - Physical Education Index KW - Blacks KW - Men KW - Heart rate KW - Medications KW - Therapy KW - Enzymes KW - Hemodynamics KW - Patients KW - Exercise KW - Exertion KW - Blood pressure KW - Higher education KW - Recruiting KW - Cardiorespiratory KW - Work load KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17177373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Beta-Blockade+Mitigates+Exercise+Blood+Pressure+in+Hypertensive+Male+Patients&rft.au=Kokkinos%2C+Peter%3BChrysohoou%2C+Christina%3BPanagiotakos%2C+Demosthenes%3BNarayan%2C+Puneet%3BGreenberg%2C+Michael%3BSingh%2C+Steve&rft.aulast=Kokkinos&rft.aufirst=Peter&rft.date=2006-01-01&rft.volume=47&rft.issue=4&rft.spage=794&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/10.1016%2Fj.jacc.2005.09.057 LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Men; Blacks; Heart rate; Therapy; Medications; Hemodynamics; Enzymes; Patients; Exercise; Exertion; Blood pressure; Recruiting; Higher education; Work load; Cardiorespiratory DO - http://dx.doi.org/10.1016/j.jacc.2005.09.057 ER - TY - JOUR T1 - Can initial and additional compensatory steps be predicted in young, older, and balance-impaired older females in response to anterior and posterior waist pulls while standing? AN - 17168117; 6839305 AB - The initiation of a single compensatory step in response to balance perturbations has been predicted with accuracies of up to 71%. We sought to determine whether similar methods also could be used to predict the onset of additional compensatory steps in both healthy and balance-impaired older females. Anterior and posterior waist pulls of five different magnitudes were applied to 13 unimpaired young (mean age 23 years), 12 unimpaired older (mean age 71 years), and 15 balance-impaired older (mean age 76 years) women. Body segment kinematic data were recorded at 100 Hz. A step was predicted when the time for the center-of-mass to reach the vertical projection of the boundary of the base-of-support fell below a certain threshold. The results show that 83% of all steps and non-steps were correctly predicted at an optimal time-to-boundary threshold ( tau sub(opt)) of 0.78 s. Step prediction accuracy did not differ significantly by group: 86% of steps and non-steps by young, 84% by unimpaired old, and 82% by balance-impaired old women were correctly predicted at tau sub(opt) of 0.58, 0.67, and 0.78 s, respectively. Anterior steps and non- steps were predicted more accurately than posterior ones (94% vs. 79% correct at tau sub(opt) of 0.52 and 0.84 s, respectively) and initial steps were better predicted than additional ones (87% vs. 81% correct at tau sub(opt) of 0.77 and 0.34 s, respectively). We conclude that this step prediction method reasonably predicts initial and additional steps in the anterior and posterior direction by all three subject cohorts. JF - Journal of Biomechanics AU - Schulz, Brian W AU - Ashton-Miller, James A AU - Alexander, Neil B AD - Biomechanics Research Laboratory, Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA, brian.Schulz@med.va.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1444 EP - 1453 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 39 IS - 8 SN - 0021-9290, 0021-9290 KW - Physical Education Index KW - Stepping KW - Perturbation KW - Falls KW - Postural control KW - Aging KW - Kinematics KW - Waist KW - Women KW - Gerontology KW - Accuracy KW - Health KW - Standing KW - Balance KW - Youth KW - Biomechanics KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17168117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanics&rft.atitle=Can+initial+and+additional+compensatory+steps+be+predicted+in+young%2C+older%2C+and+balance-impaired+older+females+in+response+to+anterior+and+posterior+waist+pulls+while+standing%3F&rft.au=Kausch%2C+Otto%3BMcCormick%2C+Richard+A&rft.aulast=Kausch&rft.aufirst=Otto&rft.date=2002-03-01&rft.volume=22&rft.issue=2&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Kinematics; Waist; Women; Gerontology; Accuracy; Health; Standing; Balance; Biomechanics; Youth DO - http://dx.doi.org/10.1016/j.jbiomech.2005.04.004 ER - TY - JOUR T1 - Evaluating potentially aberrant outpatient prescriptions for extended-release oxycodone. AN - 68874679; 16333058 JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Goodman, Francine D C AU - Glassman, Peter AD - Veterans Health Administration, Pharmacy Benefits Management Strategic Healthcare Group, Hines, IL 60141, USA. francine.goodman@med.va.gov Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 SP - 2604 EP - 2608 VL - 62 IS - 24 SN - 1079-2082, 1079-2082 KW - Analgesics, Opioid KW - 0 KW - Delayed-Action Preparations KW - Narcotics KW - Oxycodone KW - CD35PMG570 KW - Index Medicus KW - Veterans KW - United States KW - Outpatients KW - United States Department of Veterans Affairs KW - Humans KW - Databases, Factual KW - Opioid-Related Disorders -- prevention & control KW - Drug Utilization Review KW - Drug Prescriptions -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68874679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Evaluating+potentially+aberrant+outpatient+prescriptions+for+extended-release+oxycodone.&rft.au=Goodman%2C+Francine+D+C%3BGlassman%2C+Peter&rft.aulast=Goodman&rft.aufirst=Francine+D&rft.date=2005-12-15&rft.volume=62&rft.issue=24&rft.spage=2604&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-01 N1 - Date created - 2005-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Gulf War Veterans' Perceptions of Illness, Exposure Concerns, and Health Risk Communication Preferences T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39917509; 4088394 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Schneiderman, Aaron I AU - Wargo, Mary K AU - Lincoln, Andrew E AU - Curbow, Barbara A AU - Kang, Han K Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Occupational health KW - Communication KW - Perception KW - Military KW - Gulf War KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39917509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Gulf+War+Veterans%27+Perceptions+of+Illness%2C+Exposure+Concerns%2C+and+Health+Risk+Communication+Preferences&rft.au=Schneiderman%2C+Aaron+I%3BWargo%2C+Mary+K%3BLincoln%2C+Andrew+E%3BCurbow%2C+Barbara+A%3BKang%2C+Han+K&rft.aulast=Schneiderman&rft.aufirst=Aaron&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence-Based Design: A More Effective Smoking Cessation Model for Women Veterans T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39849489; 4085339 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Katzburg, Judith AU - Farmer, Melissa M AU - Sherman, Scott AU - Poza, Ines Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Smoking KW - Models KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39849489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Evidence-Based+Design%3A+A+More+Effective+Smoking+Cessation+Model+for+Women+Veterans&rft.au=Katzburg%2C+Judith%3BFarmer%2C+Melissa+M%3BSherman%2C+Scott%3BPoza%2C+Ines&rft.aulast=Katzburg&rft.aufirst=Judith&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exposures of Concern for Veterans of the Vietnam War, the Persian Gulf War (1991), and the Bosnia-Kosovo Peacekeeping Activity T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39825575; 4086295 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Schneiderman, Aaron I AU - Lincoln, Andrew E AU - Wargo, Mary K AU - Curbow, Barbara A AU - Kang, Han K Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Arabian Sea, Persian Gulf KW - Vietnam KW - Gulf War KW - War KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39825575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Exposures+of+Concern+for+Veterans+of+the+Vietnam+War%2C+the+Persian+Gulf+War+%281991%29%2C+and+the+Bosnia-Kosovo+Peacekeeping+Activity&rft.au=Schneiderman%2C+Aaron+I%3BLincoln%2C+Andrew+E%3BWargo%2C+Mary+K%3BCurbow%2C+Barbara+A%3BKang%2C+Han+K&rft.aulast=Schneiderman&rft.aufirst=Aaron&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Surveillance of Rectal Cancer Patients After Potentially Curative Initial Treatment T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39816710; 4086050 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Johnson, Frank E AU - Lee, Paul A AU - McGarry, Alaine E AU - Gammon, Steven R AU - Grossmann, Erik M AU - Longo, Walter E AU - Ode, Kenichi AU - Audisio, Riccardo A AU - Shariff, Umar S AU - Papettas, Trifonas AU - Virgo, Katherine S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Cancer KW - Rectum KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39816710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Surveillance+of+Rectal+Cancer+Patients+After+Potentially+Curative+Initial+Treatment&rft.au=Johnson%2C+Frank+E%3BLee%2C+Paul+A%3BMcGarry%2C+Alaine+E%3BGammon%2C+Steven+R%3BGrossmann%2C+Erik+M%3BLongo%2C+Walter+E%3BOde%2C+Kenichi%3BAudisio%2C+Riccardo+A%3BShariff%2C+Umar+S%3BPapettas%2C+Trifonas%3BVirgo%2C+Katherine+S&rft.aulast=Johnson&rft.aufirst=Frank&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Acute and Chronic Discrimination on Unmet Medical Needs T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39776843; 4086013 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Burgess, Diana AU - Hargreaves, Margaret AU - Van Ryn, Michelle AU - Ding, Yingmei AU - Chiezah, Michelle AU - Swaney, Sheldon Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Discrimination KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39776843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Effect+of+Acute+and+Chronic+Discrimination+on+Unmet+Medical+Needs&rft.au=Burgess%2C+Diana%3BHargreaves%2C+Margaret%3BVan+Ryn%2C+Michelle%3BDing%2C+Yingmei%3BChiezah%2C+Michelle%3BSwaney%2C+Sheldon&rft.aulast=Burgess&rft.aufirst=Diana&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - War-Related Illness and Injury Study Centers: A Resource for Deployment-Related Health Concerns T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39766381; 4086253 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Schneiderman, Aaron I AU - Lincoln, Andrew E AU - Helmer, Drew AU - Copeland, H Liesel AU - Prisco, Michelle K AU - Lange, Gudrun AU - Kang, Han K AU - Natelson, Benjamin H Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Injuries KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39766381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=War-Related+Illness+and+Injury+Study+Centers%3A+A+Resource+for+Deployment-Related+Health+Concerns&rft.au=Schneiderman%2C+Aaron+I%3BLincoln%2C+Andrew+E%3BHelmer%2C+Drew%3BCopeland%2C+H+Liesel%3BPrisco%2C+Michelle+K%3BLange%2C+Gudrun%3BKang%2C+Han+K%3BNatelson%2C+Benjamin+H&rft.aulast=Schneiderman&rft.aufirst=Aaron&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Past Experience of a Chemical/Biological Threat: Perceptions and Information Needs of Gulf War I Veterans Over a Decade Later T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39760766; 4088393 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Wargo, Mary K AU - Schneiderman, Aaron I AU - Curbow, Barbara A AU - Kang, Han K AU - Green, Stephanie M Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Perception KW - Gulf War KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39760766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Past+Experience+of+a+Chemical%2FBiological+Threat%3A+Perceptions+and+Information+Needs+of+Gulf+War+I+Veterans+Over+a+Decade+Later&rft.au=Wargo%2C+Mary+K%3BSchneiderman%2C+Aaron+I%3BCurbow%2C+Barbara+A%3BKang%2C+Han+K%3BGreen%2C+Stephanie+M&rft.aulast=Wargo&rft.aufirst=Mary&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Antibiotics and gastrointestinal colonization by vancomycin-resistant enterococci AN - 872136608; 14052307 AB - Although several classes of antimicrobial agents have been associated with colonization or infection with glycopeptide-resistant enterococci (GRE) in individual clinical studies, the agents most commonly implicated are extended-spectrum cephalosporins and compounds with potent activity against anaerobic bacteria, including ticarcillin-clavulanic acid. In some clinical studies, formulary alterations designed to minimize the use of extended-spectrum cephalosporins or ticarcillin-clavulanic acid have resulted in significant decreases in colonization and infection by GRE. Experimental data using a mouse model of GRE gastrointestinal colonization indicate that persistence of high-level GRE colonization of the mouse gastrointestinal tract is promoted by exposure to agents with potent activity against anaerobic bacteria, suggesting that reduction of competing flora is the major factor leading to persistence of high-level colonization. One study performed in humans is consistent with this model and suggests that high levels of colonization may promote spread of resistant organisms in the nosocomial setting. Establishing colonization with GRE in uncolonized mice correlates with exposure to agents that are (a) secreted into the bile in significant concentrations and (b) have negligible activity against the colonizing enterococcal strain. Differences between piperacillin-tazobactam and ceftriaxone in the establishment model can be attributed directly to differences in their anti-enterococcal activity. Modification of antimicrobial prescribing practices may play an important role in facilitating successful infection control efforts to limit GRE in the nosocomial setting. JF - European Journal of Clinical Microbiology & Infectious Diseases AU - Rice, L B AD - Medical Service 111(W), Louis Stokes Cleveland VA Medical Center and Case Medical School, 10701 East Boulevard, Cleveland, OH 44106, USA, louis.rice@med.va.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 804 EP - 814 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 24 IS - 12 SN - 0934-9723, 0934-9723 KW - Microbiology Abstracts B: Bacteriology KW - piperacillin-tazobactam KW - Cephalosporins KW - Data processing KW - Animal models KW - Antibiotics KW - Ceftriaxone KW - Infection KW - Antimicrobial agents KW - Colonization KW - Bile KW - Gastrointestinal tract KW - Anaerobic bacteria KW - Hospitals KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872136608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.atitle=Antibiotics+and+gastrointestinal+colonization+by+vancomycin-resistant+enterococci&rft.au=Rice%2C+L+B&rft.aulast=Rice&rft.aufirst=L&rft.date=2005-12-01&rft.volume=24&rft.issue=12&rft.spage=804&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.issn=09349723&rft_id=info:doi/10.1007%2Fs10096-005-0057-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - piperacillin-tazobactam; Cephalosporins; Data processing; Animal models; Antibiotics; Ceftriaxone; Infection; Antimicrobial agents; Colonization; Bile; Gastrointestinal tract; Hospitals; Anaerobic bacteria DO - http://dx.doi.org/10.1007/s10096-005-0057-z ER - TY - JOUR T1 - Posttraumatic Growth among American Former Prisoners of War AN - 867734484; 13474365 AB - Posttraumatic growth was assessed in a community sample of 95 former prisoners of war studied over a 12 year period. Developmental history, personality, social support, and PTSD measures from two earlier time points were used to predict current scores on the Posttraumatic Growth Inventory (PTGI). We hypothesized positive predictive relationships between PTGI indices and trauma exposure (and corresponding distress levels), positive affect, and social support. Positive Affectivity, Constraint, and two Social Support measures followed a pattern of significant and near-significant positive correlations with PTGI total score, Relationships with Others, and Spiritual Change, suggesting multidirectional relationships among these variables. POW trauma exposure correlated with Perceived Strength. Regression analyses significantly predicted PTGI total score, Improved Relationships, and Spiritual Change. The results both lend support to and raise questions about the construct validity of the PTGI. JF - Traumatology AU - Erbes, Christopher AU - Eberly, Raina AU - Dikel, Thomas AU - Johnsen, Erica AU - Harris, Irene AU - Engdahl, Brian AD - U.S. Department of Veterans Affairs Medical Center, Minneapolis, Minnesota, brian.engdahl@med.va.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 285 EP - 295 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 11 IS - 4 SN - 1534-7656, 1534-7656 KW - Health & Safety Science Abstracts KW - Historical account KW - posttraumatic stress disorder KW - personality KW - war KW - prisons KW - Growth KW - Perception KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867734484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traumatology&rft.atitle=Posttraumatic+Growth+among+American+Former+Prisoners+of+War&rft.au=Erbes%2C+Christopher%3BEberly%2C+Raina%3BDikel%2C+Thomas%3BJohnsen%2C+Erica%3BHarris%2C+Irene%3BEngdahl%2C+Brian&rft.aulast=Erbes&rft.aufirst=Christopher&rft.date=2005-12-01&rft.volume=11&rft.issue=4&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Traumatology&rft.issn=15347656&rft_id=info:doi/10.1177%2F153476560501100407 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - prisons; Historical account; Growth; posttraumatic stress disorder; Perception; personality; war DO - http://dx.doi.org/10.1177/153476560501100407 ER - TY - JOUR T1 - Tinidazole: a nitroimidazole antiprotozoal agent. AN - 70135081; 16507373 AB - Tinidazole, a structural analogue of metrondazole, is an antiprotozoal agent that has been widely used in Europe and developing countries for >2 decades with established efficacy and acceptable tolerability. It was recently approved by the US Food and Drug Administration for the treatment of trichomoniasis, giardiasis, amebiasis, and amebic liver abscess. This article reviews the pharmacologic and pharmacokinetic properties and clinical usefulness of tinidazole. Relevant information was identified through a search of MEDLINE (1966-August 2005), Iowa Drug Information Service (1966-August 2005), and International Pharmaceutical Abstracts (1970-August 2005) using the terms tinidazole, Fasigyn, and nitroimidazole. In vitro, tinidazole exhibits activity against pathogenic protozoa (eg, Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis), a wide range of clinically significant anaerobic bacteria (eg, Bacteroides fragilis, Clostridium difficile), and the microaerophilic bacterium Helicobacter pylori. In susceptible protozoal and bacterial cells, tinidazole is reduced to cytotoxic intermediates that covalently bind to DNA, causing irreversible damage. In human adults, tinidazole had a bioavailability of 100% and a V(d) of 50.7 L, was minimally bound to plasma protein (12%), had a plasma elimination t((1/2)) of 12.3 hours, and was eliminated primarily by hepatic metabolism (approximately 63%). Dose adjustment does not appear to be necessary on the basis of race, sex, or renal function. No data were found on the disposition of tinidazole in patients with hepatic insufficiency; therefore, use of tinidazole in patients with severe hepatic impairment (Child-Pugh class C) is not recommended. Clinical cure rates in patients with trichomoniasis, giardiasis, amebiasis, and amebic liver abscess were generally >90%. In comparative trials, tinidazole was as effective as metronidazole in the treatment of trichomoniasis and was significantly more effective than metronidazole in the treatment of giardiasis (P 1%) adverse effects included bitter taste, nausea, abdominal discomfort, anorexia, vomiting, and fatigue. The recommended dosage of tinidazole is a single dose of 2 g for trichomoniasis and giardiasis, and 2 g/d for 3 to 5 days for amebiasis. Tinidazole appears to be a promising agent for the treatment of trichomoniasis, giardiasis, amebiasis, and amebic liver abscess. Clinical studies are needed to evaluate the use of tinidazole against anaerobic bacteria and H pylori. JF - Clinical therapeutics AU - Fung, Horatio B AU - Doan, Thien-Ly AD - Medical/Surgical Patient Care Center, James J. Peters Veterans Affairs Medical Center, Bronx, New York 10468, USA. horatio.fung@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1859 EP - 1884 VL - 27 IS - 12 SN - 0149-2918, 0149-2918 KW - Antiprotozoal Agents KW - 0 KW - Tinidazole KW - 033KF7V46H KW - Index Medicus KW - Molecular Structure KW - Drug Interactions KW - Humans KW - Clinical Trials as Topic KW - Tinidazole -- pharmacology KW - Antiprotozoal Agents -- pharmacology KW - Tinidazole -- chemistry KW - Tinidazole -- economics KW - Antiprotozoal Agents -- chemistry KW - Antiprotozoal Agents -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70135081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Violence+among+individuals+in+substance+abuse+treatment%3A+the+role+of+alcohol+and+cocaine+consumption.&rft.au=Chermack%2C+Stephen+T%3BBlow%2C+Frederic+C&rft.aulast=Chermack&rft.aufirst=Stephen&rft.date=2002-03-01&rft.volume=66&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-11 N1 - Date created - 2006-03-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of repetitive nerve stimulation in the evaluation of neuromuscular junction disorders. AN - 70128298; 16457051 AB - Neuromuscular junction (NMJ) disorders are characterized by fuctuating muscle weakness. Acquired myasthenia gravis is the most common NMJ disorder with an overall prevalence in United States estimated at 60,000. Depending on the site of neuromuscular transmission failure, NMJ disorders have been classified as: (1) presynaptic (e.g., Lambert-Eaton myasthenic syndrome), (2) synaptic (e.g., cholinesterase inhibitor toxicity), and (3) post-synaptic (e.g., myasthenia gravis). Electrodiagnostic techniques used for investigation of NMJ disorders include repetitive nerve stimulation (RNS) and single fiber electromyography (SFEMG). Recent literature widely explores the use of SFEMG in the diagnosis and monitoring of myasthenia gravis, but this technique has a lesser role in the daily clinical practice outside of academic institutions. RNS is not as sensitive as SFEMG, but it is the most widely used electrodiagnostic method in the evaluation of suspected neuromuscular transmission disorders. RNS is technically easier and does not require special technical training and skill as SFEMG. Repetitive nerve stimulation was utilized first by Jolly in 1895 using an electrical drum and faradic tetanization to demonstrate a "myasthenic reaction" (weakening muscle contractions). In 1941, decremental response following the repetitive nerve stimulation was described by Harvey and Masland. While the technology has improved tremendously since then, the RNS testing is still based on supramaximal repetitive nerve stimulation and the measurement of decremental (or incremental) responses. JF - American journal of electroneurodiagnostic technology AU - Zivković, Sasa A AU - Shipe, Carol AD - Veterans Administration Pittsburgh Healthcare System and University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania 15213, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 248 EP - 261 VL - 45 IS - 4 SN - 1086-508X, 1086-508X KW - Index Medicus KW - Practice Patterns, Physicians' KW - Humans KW - Practice Guidelines as Topic KW - Electric Stimulation -- methods KW - Electromyography -- methods KW - Muscle, Skeletal -- innervation KW - Synaptic Transmission KW - Neuromuscular Junction Diseases -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70128298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+electroneurodiagnostic+technology&rft.atitle=Use+of+repetitive+nerve+stimulation+in+the+evaluation+of+neuromuscular+junction+disorders.&rft.au=Zivkovi%C4%87%2C+Sasa+A%3BShipe%2C+Carol&rft.aulast=Zivkovi%C4%87&rft.aufirst=Sasa&rft.date=2005-12-01&rft.volume=45&rft.issue=4&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=American+journal+of+electroneurodiagnostic+technology&rft.issn=1086508X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2006-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Abstinence self-efficacy and abstinence 1 year after substance use disorder treatment. AN - 69064124; 16392990 AB - To better understand the relationship between abstinence self-efficacy and treatment outcomes in substance use disorder patients, experts in the field need more information about the levels of abstinence self-efficacy most predictive of treatment outcomes. Participants (N = 2,967) from 15 residential substance use disorder treatment programs were assessed at treatment entry, discharge, and 1-year follow-up. A signal detection analysis compared the ability of different measures of self-efficacy to predict 1-year abstinence and identified the optimal cutoffs for significant predictors. The maximal level of abstinence self-efficacy (i.e., 100% confident) measured at discharge was the strongest predictor of 1-year abstinence. Treatment providers should focus on obtaining high levels of abstinence self-efficacy during treatment with the goal of achieving 100% confidence in abstinence. JF - Journal of consulting and clinical psychology AU - Ilgen, Mark AU - McKellar, John AU - Tiet, Quyen AD - Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System, CA 94025, USA. mark.ilgen@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1175 EP - 1180 VL - 73 IS - 6 SN - 0022-006X, 0022-006X KW - Index Medicus KW - ROC Curve KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Time Factors KW - Remission Induction KW - Substance-Related Disorders -- therapy KW - Self Efficacy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69064124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+consulting+and+clinical+psychology&rft.atitle=Abstinence+self-efficacy+and+abstinence+1+year+after+substance+use+disorder+treatment.&rft.au=Ilgen%2C+Mark%3BMcKellar%2C+John%3BTiet%2C+Quyen&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2005-12-01&rft.volume=73&rft.issue=6&rft.spage=1175&rft.isbn=&rft.btitle=&rft.title=Journal+of+consulting+and+clinical+psychology&rft.issn=0022006X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-14 N1 - Date created - 2006-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol-induced bone loss and deficient bone repair. AN - 69045794; 16385177 AB - Chronic consumption of excessive alcohol eventually results in an osteopenic skeleton and increased risk for osteoporosis. Alcoholics experience not only increased incidence of fractures from falls, but also delays in fracture healing compared with non-alcoholics. In this review the term "alcohol-induced bone disease" is used to refer to these skeletal abnormalities. Alcohol-induced osteopenia is distinct from osteoporoses such as postmenopausal osteoporosis and disuse osteoporosis. Gonadal insufficiency increases the rate of bone remodeling, whereas alcohol decreases this rate. Thus, histomorphometric studies show different characteristics for the bone loss that occurs in these two disease states. In particular, alcohol-induced osteopenia results mainly from decreased bone formation rather than increased bone resorption. Human, animal and cell culture studies of the effects of alcohol on bone strongly suggest alcohol has a dose-dependent toxic effect on osteoblast activity. The capacity of bone marrow stromal cells to differentiate into osteoblasts has a critical role in the cellular processes involved in the maintenance of the adult human skeleton by bone remodeling. Chronic alcohol consumption suppresses osteoblastic differentiation of bone marrow cells and promotes adipogenesis. In fracture healing, the effect of alcohol is to suppress synthesis of an ossifiable matrix, possibly due to inhibition of cell proliferation and maldifferentiation of mesenchymal cells in the repair tissue. This results in the deficient bone repair observed in animal studies, characterized by repair tissue of lower stiffness, strength and mineral content. Current knowledge of cellular effects and molecular mechanisms involved in alcohol-induced bone disease is insufficient to develop interventional strategies for its prevention and treatment. The objectives of this review are 1) to identify the characteristics of alcohol-induced bone loss and deficient bone repair as revealed in human and animal studies, 2) to determine the current understanding of the cellular effects underlying both skeletal abnormalities, and 3) to suggest directions for future studies to resolve current ambiguities regarding the cellular basis of alcohol-induced bone disease. JF - Alcoholism, clinical and experimental research AU - Chakkalakal, Dennis A AD - Orthopaedic Research Laboratory and Alcohol Research Center, Omaha Veterans Affairs Medical Center, Creighton University Biomedical Engineering Research Center and Department of Surgery, Omaha, Nebraska 68105, USA. DennisChakkalakal@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 2077 EP - 2090 VL - 29 IS - 12 SN - 0145-6008, 0145-6008 KW - Central Nervous System Depressants KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Animals KW - Humans KW - Bone Resorption -- pathology KW - Ethanol -- adverse effects KW - Central Nervous System Depressants -- adverse effects KW - Bone Diseases, Metabolic -- pathology KW - Bone Diseases, Metabolic -- chemically induced KW - Bone Development -- drug effects KW - Bone Diseases, Metabolic -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69045794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Alcohol-induced+bone+loss+and+deficient+bone+repair.&rft.au=Chakkalakal%2C+Dennis+A&rft.aulast=Chakkalakal&rft.aufirst=Dennis&rft.date=2005-12-01&rft.volume=29&rft.issue=12&rft.spage=2077&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-21 N1 - Date created - 2005-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationships between cigarette consumption and biomarkers of tobacco toxin exposure. AN - 68911770; 16365017 AB - Epidemiologic studies show a dose-response relationship between cigarettes per day and health outcomes such as heart and lung disease, and health outcomes are related to some biomarkers of tobacco exposure. The objective of this study was to examine the relationships between cigarettes per day and levels of selected biomarkers of tobacco toxin exposure: carbon monoxide (CO), metabolites of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and polycyclic aromatic hydrocarbons [total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and 1-hydroxypyrene (1-HOP), respectively], and total cotinine (cotinine plus cotinine-N-glucuronide). We did a cross-sectional analysis of merged data from (a) two clinical trials and (b) two cohorts of light smokers (total n = 400). The mean age of participants was 50.4 years and the range of cigarette consumption was 1 to 100/d; however, few subjects smoked >45 cigarettes/d (n = 12). Results show that levels of the biomarkers CO, total NNAL, and total cotinine increase with an increase in the number of cigarettes smoked per day, but not in a linear fashion. 1-HOP is a less discriminating biomarker as levels are relatively stable regardless of the number of cigarettes smoked per day. There is considerable variability in toxin measurement, especially at high levels of smoking. There was a significant correlation between cigarettes per day and total NNAL, 1-HOP, total cotinine, and CO. Total NNAL was highly significantly correlated with total cotinine and CO and also significantly correlated with 1-HOP. These findings suggest that the number of cigarettes smoked per day is not necessarily a reliable measure of toxin exposure and may underestimate tobacco toxin exposure at low levels of smoking or overestimate exposure at high levels of smoking. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Joseph, Anne M AU - Hecht, Stephen S AU - Murphy, Sharon E AU - Carmella, Steven G AU - Le, Chap T AU - Zhang, Yan AU - Han, Shaomei AU - Hatsukami, Dorothy K AD - Section of General Internal Medicine (111-0), VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA. Anne.M.Joseph@va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 2963 EP - 2968 VL - 14 IS - 12 SN - 1055-9965, 1055-9965 KW - 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol KW - 0 KW - Biomarkers KW - Nitrosamines KW - Polycyclic Aromatic Hydrocarbons KW - Pyridines KW - cotinine N-glucuronide KW - Carbon Monoxide KW - 7U1EE4V452 KW - Cotinine KW - K5161X06LL KW - Index Medicus KW - Cross-Sectional Studies KW - Randomized Controlled Trials as Topic KW - Endpoint Determination KW - Humans KW - Middle Aged KW - Urinalysis KW - Male KW - Female KW - Cotinine -- urine KW - Smoking KW - Pyridines -- urine KW - Nitrosamines -- urine KW - Cotinine -- analogs & derivatives KW - Biomarkers -- urine KW - Polycyclic Aromatic Hydrocarbons -- urine KW - Carbon Monoxide -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68911770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Relationships+between+cigarette+consumption+and+biomarkers+of+tobacco+toxin+exposure.&rft.au=Joseph%2C+Anne+M%3BHecht%2C+Stephen+S%3BMurphy%2C+Sharon+E%3BCarmella%2C+Steven+G%3BLe%2C+Chap+T%3BZhang%2C+Yan%3BHan%2C+Shaomei%3BHatsukami%2C+Dorothy+K&rft.aulast=Joseph&rft.aufirst=Anne&rft.date=2005-12-01&rft.volume=14&rft.issue=12&rft.spage=2963&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2005-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Heat decreases formoterol delivery. AN - 68900964; 16354878 AB - Based on anecdotal reports of formoterol aggregating in mailboxes in the summer in Arizona, we examined the effect of heat on formoterol as well as on drug delivery. Formoterol capsules in original blister packaging were heated to 40 to 70 degrees C (104 to 158 degrees F) for 3 h and at 70 degrees C (158 degrees F) for 15 to 180 min. Capsules were removed from packaging, and a vacuum setup was used to dispense the formoterol into a filter using the device provided by the manufacturer. The weights of the capsule predispensation and postdispensation were measured to calculate drug delivery. Measurements were compared to those of capsules not exposed to heat. For comparison, tiotropium and a combination of fluticasone propionate and salmeterol (Advair; GlaxoSmithKline; Research Triangle Park, NC) were similarly tested. Visual inspection of the heated capsules revealed gross distortion as well as visible clumping of formoterol at the higher temperatures. The mean (+/- SEM) change in the weights of capsules that underwent heating were significantly less than those obtained from capsules that had not been heated (mean change after heating for 3 h at 70 degrees C, 2.3 +/- 0.7 vs 24.7 +/- 0.6 mg, respectively; p < 0.001), indicating decreased formoterol delivery. Heat produced a dose-responsive and time-responsive decrease in formoterol delivery. One of six capsules that were subjected to temperatures as low as 40 degrees C (104 degrees F) for 3 h had decreased delivery, and three of six capsules subjected to a temperature of 70 degrees C (158 degrees F) for times as short as 30 min decreased delivery. In contrast, neither tiotropium nor fluticasone propionate/salmeterol delivery was decreased by heating for up to 3 h at 70 degrees C (158 degrees F). Thermometers placed in mailboxes or in car windows in mid-summer in Arizona (approximate outside temperature, 110 degrees F [43 degrees C]) exceeded 70 degrees C (158 degrees F). These data demonstrate that the exposure of formoterol to heat decreases drug delivery and that caution should be used when mailing, transporting or storing formoterol. JF - Chest AU - Robbins, Richard A AU - Thomas, Allen R AU - Proctor, Lynda M AU - Hoyt, Jeffrey C AU - Hayden, John M AD - Pulmonary and Critical Care Medicine, Carl T. Hayden VA Medical Center, 650 East Indian School Rd, Phoenix, AZ 85012, USA. Richard.Robbins2@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 4036 EP - 4040 VL - 128 IS - 6 SN - 0012-3692, 0012-3692 KW - Bronchodilator Agents KW - 0 KW - Ethanolamines KW - Formoterol Fumarate KW - W34SHF8J2K KW - Abridged Index Medicus KW - Index Medicus KW - Sensitivity and Specificity KW - Drug Delivery Systems KW - Asthma -- drug therapy KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Pulmonary Disease, Chronic Obstructive -- drug therapy KW - Administration, Inhalation KW - Ethanolamines -- pharmacology KW - Bronchodilator Agents -- pharmacology KW - Bronchodilator Agents -- administration & dosage KW - Ethanolamines -- administration & dosage KW - Hot Temperature -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68900964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Heat+decreases+formoterol+delivery.&rft.au=Robbins%2C+Richard+A%3BThomas%2C+Allen+R%3BProctor%2C+Lynda+M%3BHoyt%2C+Jeffrey+C%3BHayden%2C+John+M&rft.aulast=Robbins&rft.aufirst=Richard&rft.date=2005-12-01&rft.volume=128&rft.issue=6&rft.spage=4036&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-17 N1 - Date created - 2005-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic hepatitis C in patients with HIV/AIDS: a new challenge in antiviral therapy. AN - 68887016; 16308419 AB - HIV-infected patients are living longer since the introduction of highly active antiretroviral therapy. However, coinfection with the hepatitis C virus (HCV) leads to increased morbidity from liver disease and higher overall mortality. The prevalence of chronic hepatitis C among patients with HIV/AIDS ranges from 7% (sexual transmission of HIV) to >90% (injection drug use). Uncontrolled HIV infection seems to accelerate the progression of HCV-induced liver fibrosis. Forty-eight weeks of combination therapy with pegylated interferon alpha (2a or 2b) plus ribavirin achieves a sustained viral response in coinfected individuals in up to 38% with HCV genotype 1 and up to 73% with genotypes 2 or 3. The safety profile of this treatment is similar to therapy in HCV-monoinfected patients with influenza-like symptoms, cytopenia and neuropsychiatric symptoms dominating. However, HIV/HCV-coinfected patients who also take zidovudine develop more profound anaemia than those on other HIV nucleoside analogue therapy. Didanosine and stavudine are associated with rare but serious mitochondrial toxicity, such as pancreatitis or lactic acidosis. It does not appear that the addition of ribavirin increases that risk. There is currently no evidence that in HIV/HCV coinfection one pegylated interferon product is superior to the other. Contrary to common perception, it is also unproven that HIV/HCV-coinfected patients respond less well to therapy with peginterferon alpha plus ribavirin than HCV-monoinfected patients. Given the safety and efficacy of combination therapy with peginterferon plus ribavirin and the deleterious effects of chronic hepatitis C, all HIV/HCV-coinfected patients should be evaluated for therapy. JF - The Journal of antimicrobial chemotherapy AU - Bräu, Norbert AD - Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York, NY 10468, USA. norbert.brau@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 991 EP - 995 VL - 56 IS - 6 SN - 0305-7453, 0305-7453 KW - Anti-HIV Agents KW - 0 KW - Antiviral Agents KW - Interferon-alpha KW - Recombinant Proteins KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2a KW - 47RRR83SK7 KW - Ribavirin KW - 49717AWG6K KW - peginterferon alfa-2a KW - Q46947FE7K KW - Index Medicus KW - Ribavirin -- therapeutic use KW - Drug Interactions KW - Interferon-alpha -- therapeutic use KW - Randomized Controlled Trials as Topic KW - Polyethylene Glycols -- therapeutic use KW - Humans KW - Anti-HIV Agents -- adverse effects KW - Polyethylene Glycols -- adverse effects KW - Ribavirin -- adverse effects KW - Drug Therapy, Combination KW - Interferon-alpha -- adverse effects KW - Anti-HIV Agents -- therapeutic use KW - Antiretroviral Therapy, Highly Active KW - Antiviral Agents -- therapeutic use KW - HIV Infections -- complications KW - Hepatitis C, Chronic -- drug therapy KW - Hepatitis C, Chronic -- complications KW - HIV Infections -- drug therapy KW - Antiviral Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68887016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+antimicrobial+chemotherapy&rft.atitle=Chronic+hepatitis+C+in+patients+with+HIV%2FAIDS%3A+a+new+challenge+in+antiviral+therapy.&rft.au=Br%C3%A4u%2C+Norbert&rft.aulast=Br%C3%A4u&rft.aufirst=Norbert&rft.date=2005-12-01&rft.volume=56&rft.issue=6&rft.spage=991&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+antimicrobial+chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-21 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of childhood abuse on the course of bipolar disorder: a replication study in U.S. veterans. AN - 68882960; 16213029 AB - The association between early childhood abuse and the course of illness, including psychiatric comorbidities, in adults with bipolar disorder has not been examined in a predominantly male or veteran population. As part of the VA Cooperative Study 430, "Reducing the Efficacy-Effectiveness Gap in Bipolar Disorder," 330 veterans (91% male) with bipolar I or II disorder who were enrolled in a 3-year prospective study were examined for baseline data obtained at study entry. Diagnoses were determined by the use of the SCID. A semistructured interview designed to elicit data about exposure to childhood physical, sexual, or combined abuse was conducted as part of baseline demographic and clinical information. Other reports from this data set have not addressed the issues of childhood adversity. Childhood abuse was reported by 48.3% of the subjects (47.3% of men). Any abuse (AA) was reported by 48.3%; sexual abuse without physical abuse (SA) was reported by 8%, physical abuse without sexual abuse (PA) by 20.7%, and both types of abuse (combined abuse, CA) by 18.7% of the male subjects. Female veterans reported more SA (27%) and less PA (6.7%). AA subjects were more likely to have current PTSD and lifetime diagnoses of panic disorder and alcohol use disorders. CA was associated with lower SF-36 Mental scores, higher likelihood of current PTSD and lifetime diagnoses of alcohol use disorders, as well as more lifetime episodes of major depression and higher likelihood of at least one suicide attempt. Younger age at study entry was associated with AA and PA. Potential limitations include generalizability beyond the male, veteran population of patients with bipolar disorder and the methodology used to elicit abuse histories. Similar to studies of predominantly female nonveteran samples, this study extends the finding that a history of childhood abuse acts as a disease course modifier in male veterans with bipolar disorder. Clinicians should routinely seek information regarding abuse and be aware that these patients may be more difficult to treat than bipolar patients who have no abuse histories. JF - Journal of affective disorders AU - Brown, George R AU - McBride, Linda AU - Bauer, Mark S AU - Williford, William O AU - Cooperative Studies Program 430 Study Team AD - Mountain Home VAMC and East Tennessee State University, Johnson City, TN, USA. George.brown@med.va.gov ; Cooperative Studies Program 430 Study Team Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 57 EP - 67 VL - 89 IS - 1-3 SN - 0165-0327, 0165-0327 KW - Index Medicus KW - United States KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Sex Factors KW - Reproducibility of Results KW - Stress Disorders, Post-Traumatic -- psychology KW - Humans KW - Child KW - Depressive Disorder, Major -- epidemiology KW - Alcoholism -- psychology KW - Likelihood Functions KW - Comorbidity KW - Health Services Accessibility -- statistics & numerical data KW - Panic Disorder -- psychology KW - Prospective Studies KW - Panic Disorder -- epidemiology KW - Alcoholism -- epidemiology KW - Depressive Disorder, Major -- psychology KW - Adult KW - Middle Aged KW - Statistics as Topic KW - Female KW - Male KW - Child Abuse, Sexual -- psychology KW - Child Abuse -- psychology KW - Bipolar Disorder -- epidemiology KW - Veterans -- statistics & numerical data KW - Child Abuse -- statistics & numerical data KW - Veterans -- psychology KW - Child Abuse, Sexual -- statistics & numerical data KW - Bipolar Disorder -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68882960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+affective+disorders&rft.atitle=Impact+of+childhood+abuse+on+the+course+of+bipolar+disorder%3A+a+replication+study+in+U.S.+veterans.&rft.au=Brown%2C+George+R%3BMcBride%2C+Linda%3BBauer%2C+Mark+S%3BWilliford%2C+William+O%3BCooperative+Studies+Program+430+Study+Team&rft.aulast=Brown&rft.aufirst=George&rft.date=2005-12-01&rft.volume=89&rft.issue=1-3&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Journal+of+affective+disorders&rft.issn=01650327&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-03 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dextromethorphan psychosis, dependence and physical withdrawal. AN - 68845841; 16318953 AB - As part of a synthesis of evidence regarding the abuse and addiction liability of dextromethorphan (DM), an over-the-counter cough medicine available in over 140 preparations, an uncommonly published case of dextromethorphan dependence (addiction) is described, with specific, rarely published complications. The individual was interviewed and several medical databases were also reviewed (Medline, 1966-present; PubMed) for all content relating to the Keywords: dextromethorphan, abuse, dependence, cough medicine, addiction, withdrawal, psychosis. The patient evidenced history suggesting substance dependence, substance-induced psychosis and substance withdrawal in relation to DM. A literature review revealed that DM has specific serotonergic and sigma-1 opioidergic properties. Dextrorphan (DOR), the active metabolite of DM, has similar properties; however, DOR is a weaker sigma opioid receptor agonist, and a stronger NMDA receptor antagonist. DM and DOR display specific biological features of addiction, and are capable of inducing specific psychiatric sequelae. A specific, reproducible toxidrome with significant psychiatric effects occurred, when DM was abused at greater than indicated doses, with more profound and potentially life-threatening effects at even higher doses. DM withdrawal appears evident. DM's active metabolite, DOR, has pharmacodynamic properties and intoxication effects similar to dissociatives, and may be more responsible for the dissociative effect that this DM abuser sought. However, it is this same metabolite that may be fraught with the potentially life-threatening psychoses and dissociative-induced accidents, as well as addiction. While DM has been hypothesized as the most commonly abused dissociative, health-care providers seem largely unaware of its toxidrome and addiction liability. JF - Addiction biology AU - Miller, Shannon C AD - Addiction Services, Veterans Administration Medical Center and Associate Professor, Department of Psychiatry, Wright State University School of Medicine, Dayton, OH 45428, USA. shannon.miller2@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 325 EP - 327 VL - 10 IS - 4 SN - 1355-6215, 1355-6215 KW - Analgesics, Opioid KW - 0 KW - Antitussive Agents KW - Nonprescription Drugs KW - Receptors, sigma KW - Dextrorphan KW - 04B7QNO9WS KW - Dextromethorphan KW - 7355X3ROTS KW - Index Medicus KW - Drug Tolerance KW - Hallucinations -- chemically induced KW - Dose-Response Relationship, Drug KW - Humans KW - Dextrorphan -- toxicity KW - Adult KW - Receptors, sigma -- agonists KW - Delusions -- chemically induced KW - Recurrence KW - Female KW - Substance Withdrawal Syndrome -- etiology KW - Dextromethorphan -- toxicity KW - Substance Withdrawal Syndrome -- rehabilitation KW - Antitussive Agents -- toxicity KW - Substance-Related Disorders -- etiology KW - Nonprescription Drugs -- toxicity KW - Psychoses, Substance-Induced -- etiology KW - Substance-Related Disorders -- rehabilitation KW - Psychoses, Substance-Induced -- rehabilitation KW - Analgesics, Opioid -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68845841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+biology&rft.atitle=Dextromethorphan+psychosis%2C+dependence+and+physical+withdrawal.&rft.au=Miller%2C+Shannon+C&rft.aulast=Miller&rft.aufirst=Shannon&rft.date=2005-12-01&rft.volume=10&rft.issue=4&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Addiction+biology&rft.issn=13556215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-03 N1 - Date created - 2005-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Continuity of care practices and substance use disorder patients' engagement in continuing care. AN - 68817374; 16299435 AB - Substance use disorder (SUD) patients who engage in more continuing care have better outcomes, but information on practices associated with greater patient engagement and retention in continuing care remains elusive. The objectives of this study were to determine if staff's continuity of care practices predict patients' engagement in continuing care in the 6 months after discharge from intensive SUD treatment and to determine if the impact of continuity of care practices on patients' engagement in continuing care differs for patients treated in inpatient/residential versus outpatient programs. Staff in 28 Veterans Affairs (VA) intensive SUD treatment programs with varying continuity of care practices provided data on 878 patients' alcohol and drug problems at treatment entry. At discharge, staff provided data on patients' motivation, treatment intensity, and on the continuity of care practices they used with each patient. VA administrative databases supplied data on patients' subsequent engagement in continuing care. Mixed-effects modeling was used to examine predictors of patients' engagement in care. Patients in outpatient programs who received more continuity of care engaged in continuing care significantly longer. More highly motivated outpatients, those with fewer alcohol problems at treatment entry, and patients who used VA services in the year before treatment also remained in continuing care longer. These findings did not hold for patients treated in inpatient/residential programs. Continuity of care practices predicted engagement in continuing care only for patients treated in outpatient SUD programs. More research is needed to identify effective continuity of care practices for patients treated in inpatient/residential programs. JF - Medical care AU - Schaefer, Jeanne A AU - Ingudomnukul, Erin AU - Harris, Alex H S AU - Cronkite, Ruth C AD - Center for Health Care Evaluation, Department of Veterans Affairs Health Care System, Palo Alto, CA, USA. Jeanne.Schaefer@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1234 EP - 1241 VL - 43 IS - 12 SN - 0025-7079, 0025-7079 KW - Index Medicus KW - United States KW - Socioeconomic Factors KW - Outpatients KW - Substance Abuse Treatment Centers -- organization & administration KW - Motivation KW - United States Department of Veterans Affairs KW - Humans KW - Health Services Research KW - Alcohol Drinking -- adverse effects KW - Middle Aged KW - Inpatients KW - Substance-Related Disorders -- therapy KW - Continuity of Patient Care -- organization & administration KW - Patient Dropouts -- psychology KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68817374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=Continuity+of+care+practices+and+substance+use+disorder+patients%27+engagement+in+continuing+care.&rft.au=Schaefer%2C+Jeanne+A%3BIngudomnukul%2C+Erin%3BHarris%2C+Alex+H+S%3BCronkite%2C+Ruth+C&rft.aulast=Schaefer&rft.aufirst=Jeanne&rft.date=2005-12-01&rft.volume=43&rft.issue=12&rft.spage=1234&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=00257079&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-21 N1 - Date created - 2005-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms. AN - 68808587; 15907335 AB - Arsenic is a naturally occurring, worldwide contaminant implicated in numerous pathological conditions in humans, including cancer and several forms of liver disease. One of the contributing factors to these disorders may be the alteration of cytochrome P450 (CYP) levels by arsenic. In rat and human hepatocyte cultures, arsenic, in the form of arsenite, decreases the induction of several CYPs. The present study investigated whether arsenite utilizes transcriptional or post-transcriptional mechanisms to decrease CYP3A23 in primary cultures of rat hepatocytes. In these cultures, a 6-h treatment with 5 microM arsenite abolished dexamethasone (DEX)-mediated induction of CYP3A23 protein and activity, but did not inhibit general protein synthesis. However, arsenite treatment only reduced DEX-induced levels of CYP3A23 mRNA by 30%. The effects of arsenite on CYP3A23 transcription were examined using a luciferase reporter construct containing 1.4 kb of the CYP3A23 promoter. Arsenite caused a 30% decrease in DEX-induced luciferase expression of this reporter. Since arsenite abolished induction of CYP3A23 protein, but caused only a small decrease in CYP3A23 mRNA, the effects of arsenite on translation of CYP3A23 mRNA were investigated. Polysomal distribution analysis showed that arsenite decreased translation by decreasing the DEX-mediated increase in CYP3A23 mRNA association with polyribosomes. Arsenite did not decrease intracellular glutathione or increase lipid peroxidation, suggesting that the effect of arsenite on CYP3A23 does not involve oxidative stress. Overall, the results suggest that low-level arsenite decreases both transcription and translation of CYP3A23 in primary rat hepatocyte cultures. JF - Toxicology and applied pharmacology AU - Noreault, Trisha L AU - Jacobs, Judith M AU - Nichols, Ralph C AU - Trask, Heidi W AU - Wrighton, Steven A AU - Sinclair, Peter R AU - Evans, Ronald M AU - Sinclair, Jacqueline F AD - Veterans Administration Medical Center, White River Junction, VT 05009, USA. Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 174 EP - 182 VL - 209 IS - 2 SN - 0041-008X, 0041-008X KW - Arsenites KW - 0 KW - RNA, Messenger KW - Dexamethasone KW - 7S5I7G3JQL KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP3A23 protein, rat KW - Cytochrome P-450 CYP3A KW - arsenite KW - N5509X556J KW - Index Medicus KW - Animals KW - Immunoblotting KW - Hepatocytes -- drug effects KW - Dexamethasone -- pharmacology KW - Polyribosomes -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Hepatocytes -- enzymology KW - RNA, Messenger -- biosynthesis KW - Rats KW - Rats, Inbred F344 KW - Enzyme Induction -- drug effects KW - Polyribosomes -- enzymology KW - Male KW - Hepatocytes -- metabolism KW - Protein Biosynthesis -- drug effects KW - Liver -- enzymology KW - Transcription, Genetic -- drug effects KW - Liver -- drug effects KW - Aryl Hydrocarbon Hydroxylases -- antagonists & inhibitors KW - Arsenites -- toxicity KW - Liver -- metabolism KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Aryl Hydrocarbon Hydroxylases -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68808587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Arsenite+decreases+CYP3A23+induction+in+cultured+rat+hepatocytes+by+transcriptional+and+translational+mechanisms.&rft.au=Noreault%2C+Trisha+L%3BJacobs%2C+Judith+M%3BNichols%2C+Ralph+C%3BTrask%2C+Heidi+W%3BWrighton%2C+Steven+A%3BSinclair%2C+Peter+R%3BEvans%2C+Ronald+M%3BSinclair%2C+Jacqueline+F&rft.aulast=Noreault&rft.aufirst=Trisha&rft.date=2005-12-01&rft.volume=209&rft.issue=2&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-03 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differences among sexually abused and nonabused youth living with HIV. AN - 68729280; 16246916 AB - Risk behaviors were compared between sexually abused and nonabused youth living with HIV (YLH). Abused YLH were significantly more likely to have attempted suicide, to have been admitted into an alcohol and/or drug treatment program, and to have engaged in crack cocaine use than were nonabused YLH and had a greater number of sexual partners. A significantly higher proportion of abused YLH had been incarcerated in contrast to nonabused youth. There were also significantly greater conduct problems among abused YLH. Finally, abused YLH had significantly higher scores on positive action and social-support coping styles than nonabused youth. Consistent with previous research, abused youth are at higher risk for a variety of negative outcomes and are also similar in many respects to sexually abused youth who are not HIV-positive. The high frequencies of two positive styles of coping among abused YLH were also observed. JF - Journal of interpersonal violence AU - Anaya, Henry D AU - Swendeman, Dallas AU - Rotheram-Borus, Mary Jane AD - U.S. Department of Veterans Affairs. hanaya@ucla.edu Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1547 EP - 1559 VL - 20 IS - 12 SN - 0886-2605, 0886-2605 KW - Index Medicus KW - Risk-Taking KW - Adaptation, Psychological KW - Humans KW - Adult KW - Psychology, Adolescent KW - Substance-Related Disorders -- psychology KW - Adolescent KW - United States -- epidemiology KW - Sexual Behavior -- psychology KW - Male KW - Female KW - Substance-Related Disorders -- epidemiology KW - Child Abuse, Sexual -- psychology KW - Child Abuse, Sexual -- rehabilitation KW - Adolescent Behavior -- psychology KW - Health Behavior KW - Child Abuse, Sexual -- statistics & numerical data KW - HIV Infections -- psychology KW - HIV Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68729280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+interpersonal+violence&rft.atitle=Differences+among+sexually+abused+and+nonabused+youth+living+with+HIV.&rft.au=Anaya%2C+Henry+D%3BSwendeman%2C+Dallas%3BRotheram-Borus%2C+Mary+Jane&rft.aulast=Anaya&rft.aufirst=Henry&rft.date=2005-12-01&rft.volume=20&rft.issue=12&rft.spage=1547&rft.isbn=&rft.btitle=&rft.title=Journal+of+interpersonal+violence&rft.issn=08862605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-09 N1 - Date created - 2005-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An Application of Rasch Analysis to the Measurement of Communicative Functioning AN - 57069058; 200617768 AB - Purpose: The purposes of this investigation were to examine the construct dimensionality & range of ability effectively measured by 28 assessment items obtained from 3 different patient-reported scales of communicative functioning, & to provide a demonstration of how the Rasch approach to measurement may contribute to the definition of latent constructs & the development of instruments to measure them. Method: Item responses obtained from 421 stroke survivors with & without communication disorders were examined using the Rasch partial credit model. The dimensionality of the item pool was evaluated by (a) examining correlations of Rasch person ability scores obtained separately from each of the 3 scales, (b) iteratively excluding items exceeding mean square model fit criteria, & (c) using principal-components analysis of Rasch model residuals. The range of ability effectively measured by the item pool was examined by comparing item difficulty & category threshold calibrations to the distribution of person ability scores & by plotting the modeled standard error of person ability estimates as a function of person ability level. Results: The results indicate that most assessment items fit a unidimensional measurement model, with the notable exception of items relating to the use of written communication. The results also suggest that the range of ability that could be reliably measured by the current item pool was restricted relative to the range of ability observed in the patient sample. Conclusions: It is concluded that (a) a mature understanding of communicative functioning as a measurement construct will require further research, (b) patients with stroke-related communication disorders will be better served by the development of instruments measuring a wider range of communicative functioning ability, & (c) the theoretical & methodological tools provided by the Rasch family of measurement models may be productively applied to these efforts. Tables, Figures, References. Adapted from the source document. JF - Journal of Speech, Language, and Hearing Research AU - Doyle, Patrick J AU - Hula, William D AU - McNeil, Malcolm R AU - Mikolic, Joseph M AU - Matthews, Christine AD - VA Pittsburgh Healthcare Systems, PA patrick.doyle@med.va.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1412 EP - 1428 PB - American Speech-Language-Hearing Association, Rockville MD VL - 48 IS - 6 SN - 1092-4388, 1092-4388 KW - communicative functioning, outcomes, Rasch analysis, measurement KW - Evaluation KW - Rasch model KW - Communication skills KW - Measures KW - Communication disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57069058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=An+Application+of+Rasch+Analysis+to+the+Measurement+of+Communicative+Functioning&rft.au=Doyle%2C+Patrick+J%3BHula%2C+William+D%3BMcNeil%2C+Malcolm+R%3BMikolic%2C+Joseph+M%3BMatthews%2C+Christine&rft.aulast=Doyle&rft.aufirst=Patrick&rft.date=2005-12-01&rft.volume=48&rft.issue=6&rft.spage=1412&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/10.1044%2F1092-4388%282005%2F098%29 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-29 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Communication skills; Measures; Evaluation; Rasch model; Communication disorders DO - http://dx.doi.org/10.1044/1092-4388(2005/098) ER - TY - JOUR T1 - Perceptions and Attitudes about HFE Genotyping Among College-Age Adults AN - 20832148; 7024093 AB - Purpose: Examine young adults' attitudes about HFE genotyping. Methods: 121 college students read about hemochromatosis, transferrin saturation measurement (iron test), and HFE genotyping. Interest in testing and knowledge and attitudes about genetic testing were assessed. Participants were randomly assigned to predict either their response to a positive HFE genotype (genotype group) or a positive iron test (phenotype group). Results: 71% preferred the iron test, but most would undergo either test. Learning risk and early detection/prevention were the most commonly perceived benefits; limited information about health and negative emotional consequences were the most commonly perceived disadvantages. The genotype and phenotype groups did not differ in expected worry, perceived severity, perceived risk, and preventability of organ damage. After reading the description provided, participants answered 78% of knowledge questions correctly. Conclusions: Young adults view HFE genotyping positively and report few disadvantages, but prefer the iron test for its information about current health. They appear to be receptive to public health screening for hemochromatosis. JF - Journal of Genetic Counseling AU - Hicken, Bret L AU - Foshee, Aimee AU - Tucker, Diane C AD - Salt Lake City VAMC, 500 Foothill Dr, Salt Lake City, UT 84148, bret.hicken@med.va.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 465 EP - 472 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 14 IS - 6 SN - 1059-7700, 1059-7700 KW - hemochromatosis KW - Genetics Abstracts; Risk Abstracts KW - Emotions KW - Learning KW - Genotyping KW - Genotypes KW - Public health KW - Transferrin KW - Perception KW - prevention KW - Genetic screening KW - Hemochromatosis KW - Language KW - Iron KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20832148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Genetic+Counseling&rft.atitle=Perceptions+and+Attitudes+about+HFE+Genotyping+Among+College-Age+Adults&rft.au=Hicken%2C+Bret+L%3BFoshee%2C+Aimee%3BTucker%2C+Diane+C&rft.aulast=Hicken&rft.aufirst=Bret&rft.date=2005-12-01&rft.volume=14&rft.issue=6&rft.spage=465&rft.isbn=&rft.btitle=&rft.title=Journal+of+Genetic+Counseling&rft.issn=10597700&rft_id=info:doi/10.1007%2Fs10897-005-4718-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Emotions; Transferrin; Learning; Perception; Genotyping; Hemochromatosis; Language; Genotypes; Iron; Public health; prevention; Genetic screening DO - http://dx.doi.org/10.1007/s10897-005-4718-y ER - TY - CPAPER T1 - Replication of Association of IL-1 Gene Cluster Members with Ankylosing Spondylitis (AS) in Taiwanese Chinese T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39836782; 4104107 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Timms, Andrew E AU - Chou, Chung-Tei AU - Wei, James C.C. AU - Tsai, Wen C AU - Wordsworth, B.Paul AU - Brown, Matthew A Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Replication KW - Interleukin 1 KW - Ankylosing spondylitis KW - Gene clusters KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39836782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Replication+of+Association+of+IL-1+Gene+Cluster+Members+with+Ankylosing+Spondylitis+%28AS%29+in+Taiwanese+Chinese&rft.au=Timms%2C+Andrew+E%3BChou%2C+Chung-Tei%3BWei%2C+James+C.C.%3BTsai%2C+Wen+C%3BWordsworth%2C+B.Paul%3BBrown%2C+Matthew+A&rft.aulast=Timms&rft.aufirst=Andrew&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - P44 Transgenic Mice Have an Early and Dramatic Increase in Ab Levels in the Brain: A Possible Role of IGF - 1 Signaling in the Regulation of Ab Production During Aging T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39895461; 4121174 JF - 35th Annual Meeting of the Society for Neuroscience AU - Costantini, C AU - Scrable, H AU - Puglielli, L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Aging KW - Mice KW - Brain KW - Antibodies KW - Signal transduction KW - Insulin-like growth factors KW - Transgenic mice KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39895461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=P44+Transgenic+Mice+Have+an+Early+and+Dramatic+Increase+in+Ab+Levels+in+the+Brain%3A+A+Possible+Role+of+IGF+-+1+Signaling+in+the+Regulation+of+Ab+Production+During+Aging&rft.au=Costantini%2C+C%3BScrable%2C+H%3BPuglielli%2C+L&rft.aulast=Costantini&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Discriminating Patients with Frontal-Lobe Epilepsy and Temporal-Lobe Epilepsy: Utility of a Multilevel Design Fluency Test AN - 85623886; 200609041 AB - Patients with frontal-lobe epilepsy (FLE) or temporal-lobe epilepsy (TLE) & matched control participants were given a design fluency test that assessed nonverbal fluency & switching ability. Patients with FLE generated fewer designs in the switching condition relative to the TLE patients & controls, whereas group differences did not emerge in the basic fluency conditions. When the side of the seizure focus & the presence or absence of a structural lesion were considered in patients with FLE, only those with left-lesional FLE generated fewer designs than controls did in the switching condition. Furthermore, patients with left-lesional & nonlesional FLE produced a greater proportion of set-loss errors than did controls. These results indicate that patients with FLE are impaired when they must simultaneously generate new designs & engage in cognitive switching; however, the pattern of impairment may depend on the side of the seizure focus & the presence of a structural lesion. 2 Tables, 3 Figures, 31 References. [Copyright 2005 The American Psychological Association.] JF - Neuropsychology AU - McDonald, Carrie R AU - Delis, Dean C AU - Norman, Marc A AU - Tecoma, Evelyn S AU - Iragui, Vicente J AD - Delis Lab, Veterans Administration San Diego Healthcare System, La Jolla, CA camcdonald@ucsd.edu Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 806 EP - 813 VL - 19 IS - 6 SN - 0894-4105, 0894-4105 KW - Linguistic Competence (47400) KW - Brain Damage (09400) KW - Executive Function (23470) KW - Nervous System Disorders (57100) KW - Neurolinguistics (57250) KW - Measures (Instruments) (52300) KW - Fluency (24910) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85623886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychology&rft.atitle=Discriminating+Patients+with+Frontal-Lobe+Epilepsy+and+Temporal-Lobe+Epilepsy%3A+Utility+of+a+Multilevel+Design+Fluency+Test&rft.au=McDonald%2C+Carrie+R%3BDelis%2C+Dean+C%3BNorman%2C+Marc+A%3BTecoma%2C+Evelyn+S%3BIragui%2C+Vicente+J&rft.aulast=McDonald&rft.aufirst=Carrie&rft.date=2005-11-01&rft.volume=19&rft.issue=6&rft.spage=806&rft.isbn=&rft.btitle=&rft.title=Neuropsychology&rft.issn=08944105&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2006-08-01 N1 - Last updated - 2016-09-27 N1 - CODEN - NEUPEG N1 - SubjectsTermNotLitGenreText - Nervous System Disorders (57100); Brain Damage (09400); Fluency (24910); Neurolinguistics (57250); Linguistic Competence (47400); Executive Function (23470); Measures (Instruments) (52300) ER - TY - JOUR T1 - When hearing aids go bad: an FM success story. AN - 85396268; pmid-16515133 AB - Both clinical and research findings support the effectiveness of frequency-modulated (FM) technology among individuals who continue to encounter significant communication problems despite the use of conventional hearing instruments. The use rate of FM devices throughout the nation, however, remains disappointingly low. The authors present a case of a longtime hearing aid user whose hearing aids provided decreasing benefit as his hearing impairment increased to the extent that cochlear implantation was considered. Through the establishment of patient-specific treatment goals, the provision of appropriate FM technology as verified through real-ear measurements, and careful and deliberate counseling and follow-up, this patient was able to realize significant communication benefits as reported through several self-assessment measures. The cost-benefit implications of FM technology versus cochlear implantation are discussed. JF - Journal of the American Academy of Audiology AU - McArdle, Rachel AU - Abrams, Harvey B AU - Chisolm, Theresa Hnath AD - Bay Pines VA Healthcare System, Audiology (126), P.O. Box 5005, Bay Pines, FL 33744, USA. Rachel.mcardle@med.va.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 809 EP - 821 VL - 16 IS - 10 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Cost-Benefit Analysis KW - Equipment Design KW - Follow-Up Studies KW - Hearing Aids: economics KW - Hearing Aids: psychology KW - Hearing Loss: economics KW - *Hearing Loss: rehabilitation KW - Humans KW - Male KW - Patient Education as Topic KW - Patient Satisfaction KW - Questionnaires KW - Radio: instrumentation KW - Radio Waves: classification KW - *Speech Perception KW - Treatment Outcome KW - Veterans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=When+hearing+aids+go+bad%3A+an+FM+success+story.&rft.au=McArdle%2C+Rachel%3BAbrams%2C+Harvey+B%3BChisolm%2C+Theresa+Hnath&rft.aulast=McArdle&rft.aufirst=Rachel&rft.date=2005-11-01&rft.volume=16&rft.issue=10&rft.spage=809&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Use of 35 words for evaluation of hearing loss in signal-to-babble ratio: A clinic protocol. AN - 70156011; 16680621 AB - Data from earlier studies that presented 70 words at 24 to 0 dB signal-to-babble (S/B) ratios indicated that most young listeners with normal hearing required 0 to 6 dB S/B ratios to attain 50% correct word recognition. Older listeners with hearing loss often required a >12 dB S/B ratio to attain 50% correct word recognition. In our study, we converted the Words in Noise test from one 70-word list into two 35-word lists for quicker administration by clinicians. Using baseline data from previous studies, we used two strategies to randomize the 35-word lists: based on recognition performance at each S/B ratio and based on recognition performance only. With the first randomization strategy, the 50% correct word-recognition points on the two lists differed by 0.5 dB for 72 listeners with hearing loss. With the second randomization strategy, 48 listeners with hearing loss performed identically on the two lists. JF - Journal of rehabilitation research and development AU - Wilson, Richard H AU - Burks, Christopher A AD - James H. Quillen Department of Veterans Affairs Medical Center, Mountain Home, TN, USA. richard.wilson2@med.va.gov PY - 2005 SP - 839 EP - 852 VL - 42 IS - 6 KW - Index Medicus KW - Severity of Illness Index KW - Reference Values KW - Age Factors KW - Analysis of Variance KW - Auditory Threshold KW - Humans KW - Vocabulary KW - Aged KW - Verbal Behavior -- physiology KW - Aging -- physiology KW - Speech Perception KW - Aged, 80 and over KW - Audiometry, Speech -- methods KW - Adult KW - Noise KW - Middle Aged KW - Female KW - Male KW - Hearing Loss -- diagnosis KW - Speech Reception Threshold Test -- instrumentation KW - Auditory Perception -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70156011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+rehabilitation+research+and+development&rft.atitle=Use+of+35+words+for+evaluation+of+hearing+loss+in+signal-to-babble+ratio%3A+A+clinic+protocol.&rft.au=Wilson%2C+Richard+H%3BBurks%2C+Christopher+A&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2005-11-01&rft.volume=42&rft.issue=6&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=Journal+of+rehabilitation+research+and+development&rft.issn=1938-1352&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-21 N1 - Date created - 2006-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sequencing the lifetime onset of alcohol-related symptoms in older adults: is there evidence of disease progression? AN - 70121010; 16459937 AB - The purpose of this study was to evaluate evidence of orderly symptom progression in alcohol-use disorders (disease-progression model). A sample of community-residing older problem drinkers provided information about their life history of drinking, including the age at which they had experienced alcohol-related symptoms that correspond to criteria for alcohol abuse and dependence. Symptom sets and possible sequences were formulated separately for women and men, based on the average number of years from drinking initiation to symptom onset and on symptom prevalence. We assessed how well the ordering of symptoms experienced by individual respondents matched the sequences derived with these group-level measures; we also assessed whether individuals progress from alcohol abuse to dependence as is implied in some conceptualizations of alcohol-use disorders. Half or more of these older adults experienced symptom onset in an order that was inconsistent with the possible symptom sequences derived from group-level analysis (e.g., reversals from the expected order or concurrent onset of symptoms expected to occur sequentially). Similarly, alcohol abuse did not appear to be a precursor to the development of alcohol dependence in individual patterns of symptom onset. Although group-level results based on the number of years from drinking initiation to symptom onset or on symptom prevalence may seem to point to orderly progression in the development of alcohol-related symptoms, these group-level results do not capture individual experiences very well. In this community-residing sample of problem drinkers, most of whom had never sought treatment, there was marked variability in the course of symptom development, which raises questions about the utility of a disease-progression model. JF - Journal of studies on alcohol AU - Lemke, Sonne AU - Schutte, Kathleen K AU - Brennan, Penny L AU - Moos, Rudolf H AD - Department of Veterans Affairs, Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System, 795 Willow Road, Menlo Park, California 94025, USA. Sonne.Lemke@va.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 756 EP - 765 VL - 66 IS - 6 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Severity of Illness Index KW - Age of Onset KW - Humans KW - Disease Progression KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Prevalence KW - Alcoholism -- epidemiology KW - Alcoholism -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70121010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Sequencing+the+lifetime+onset+of+alcohol-related+symptoms+in+older+adults%3A+is+there+evidence+of+disease+progression%3F&rft.au=Lemke%2C+Sonne%3BSchutte%2C+Kathleen+K%3BBrennan%2C+Penny+L%3BMoos%2C+Rudolf+H&rft.aulast=Lemke&rft.aufirst=Sonne&rft.date=2005-11-01&rft.volume=66&rft.issue=6&rft.spage=756&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-25 N1 - Date created - 2006-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Health effects in Army Gulf War veterans possibly exposed to chemical munitions destruction at Khamisiyah, Iraq: Part I. Morbidity associated with potential exposure. AN - 70114254; 16450821 AB - In March 1991, U.S. troops detonated the Khamisiyah, Iraq, ammunition depot, possibly releasing two chemical warfare agents, sarin and cyclosarin. The long-term health effects associated with possible exposure to these chemical warfare agents are unknown. This study was undertaken to investigate whether possible exposure was associated with morbidity among Army Gulf War veterans using morbidity data for 5,555 Army veterans who were deployed to the Gulf region. Responses to 86 self-assessed health measures, as reported in the 1995 Department of Veterans Affairs National Health Survey of Gulf War Era Veterans, were evaluated. We found little association between potential exposure and health, after adjustment for demographic variables, and conclude that potential exposure to sarin or cyclosarin at Khamisiyah does not seem to have adversely affected self-perceived health status, as evidenced by a wide range of health measures. JF - Military medicine AU - Mahan, Clare M AU - Page, William F AU - Bullman, Tim A AU - Kang, Han K AD - Veterans Health Administration, Department of Veterans Affairs, Washington, DC 20420, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 935 EP - 944 VL - 170 IS - 11 SN - 0026-4075, 0026-4075 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - United States KW - Humans KW - Cohort Studies KW - Adult KW - Surveys and Questionnaires KW - Male KW - Iraq KW - Female KW - Military Medicine KW - Veterans KW - Hazardous Substances -- adverse effects KW - Gulf War KW - Environmental Exposure KW - Morbidity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70114254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+medicine&rft.atitle=Health+effects+in+Army+Gulf+War+veterans+possibly+exposed+to+chemical+munitions+destruction+at+Khamisiyah%2C+Iraq%3A+Part+I.+Morbidity+associated+with+potential+exposure.&rft.au=Mahan%2C+Clare+M%3BPage%2C+William+F%3BBullman%2C+Tim+A%3BKang%2C+Han+K&rft.aulast=Mahan&rft.aufirst=Clare&rft.date=2005-11-01&rft.volume=170&rft.issue=11&rft.spage=935&rft.isbn=&rft.btitle=&rft.title=Military+medicine&rft.issn=00264075&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-24 N1 - Date created - 2006-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Randomized placebo-controlled trial of a selective serotonin reuptake inhibitor in the treatment of nondepressed tinnitus subjects. AN - 68844473; 16314604 AB - To assess the efficacy of a selective serotonin reuptake inhibitor (paroxetine) for relief of tinnitus. One hundred twenty tinnitus sufferers participated in a randomized double-blind placebo-controlled trial. Paroxetine or placebo was increased to a maximally tolerated dose (up to 50 mg/day), and patients were treated for a total of 31 days at the maximal dose. Patients with chronic tinnitus were recruited from our university-based specialty clinic by referral from otolaryngologists and audiologists in the local community and by advertisement. Patients with psychotic or substance use disorders or suicidal ideation were excluded, as were those using psychoactive medications (this resulted in only 1 subject with major depression in the study) or any other medications that interact with paroxetine and those with inability to hear at one's tinnitus sensation level. Fifty-eight percent of patients were male, 92% were Caucasian, and the average age was 57. Tinnitus matching, the Tinnitus Handicap Questionnaire, the question: How severe (bothered, aggravating) is your tinnitus? Quality of Well-Being and other psychological questionnaires. Paroxetine was not statistically superior to placebo on the following tinnitus measures (tinnitus matching, 5- or 10-db drop, Tinnitus Handicap Questionnaire, quality of well-being measures, how severe, how bothered, positive change). There was a significant improvement in the single item question, How aggravating is your tinnitus? for those in the paroxetine group compared with the placebo group. These results suggest that the majority of individuals in this study did not benefit from paroxetine in a consistent fashion. Further work remains to be done to determine if subgroups of patients (e.g., those who tolerate higher doses, those who are depressed) may benefit. JF - Psychosomatic medicine AU - Robinson, Shannon K AU - Viirre, Erik S AU - Bailey, Kelly A AU - Gerke, Melissa A AU - Harris, Jeffery P AU - Stein, Murray B AD - Department of Psychiatry, University of California, San Diego School of Medicine, Veterans Administration San Diego Healthcare System, La Jolla, CA 92161, USA. skrobinson@ucsd.edu PY - 2005 SP - 981 EP - 988 VL - 67 IS - 6 KW - Placebos KW - 0 KW - Serotonin Uptake Inhibitors KW - Paroxetine KW - 41VRH5220H KW - Index Medicus KW - Severity of Illness Index KW - Drug Administration Schedule KW - Attitude to Health KW - Humans KW - Health Status KW - Treatment Outcome KW - Surveys and Questionnaires KW - Middle Aged KW - Maximum Tolerated Dose KW - Male KW - Female KW - Tinnitus -- psychology KW - Tinnitus -- diagnosis KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Tinnitus -- drug therapy KW - Paroxetine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68844473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatic+medicine&rft.atitle=Randomized+placebo-controlled+trial+of+a+selective+serotonin+reuptake+inhibitor+in+the+treatment+of+nondepressed+tinnitus+subjects.&rft.au=Robinson%2C+Shannon+K%3BViirre%2C+Erik+S%3BBailey%2C+Kelly+A%3BGerke%2C+Melissa+A%3BHarris%2C+Jeffery+P%3BStein%2C+Murray+B&rft.aulast=Robinson&rft.aufirst=Shannon&rft.date=2005-11-01&rft.volume=67&rft.issue=6&rft.spage=981&rft.isbn=&rft.btitle=&rft.title=Psychosomatic+medicine&rft.issn=1534-7796&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-11 N1 - Date created - 2005-11-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Psychosom Med. 2006 Jan-Feb;68(1):1 p preceding 1 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bleeding Risk Index in an anticoagulation clinic. Assessment by indication and implications for care. AN - 68837843; 16307625 AB - The Outpatient Bleeding Risk Index (BRI) prospectively classified patients who were at high, intermediate, or low risk for warfarin-related major bleeding. However, there are only 2 published validation studies of the index and neither included veterans. To determine the accuracy of the BRI in patients attending a Veterans Affairs (VA) anticoagulation clinic and to specifically evaluate the accuracy of the BRI in patients with atrial fibrillation. Retrospective cohort study. Using the BRI, all patients managed by the Anticoagulation Clinic between January 1, 2001 and December 31, 2002 were classified as high, intermediate, or low risk for major bleeding. Bleeds were identified via quality-assurance reports. Poisson regression was used to determine whether there was an association between the index and the development of bleeding. The rate of major bleeding was 10.6%, 2.5%, and 0.8% per patient-year of warfarin in the high-, intermediate-, and low-risk groups, respectively. Patients in the high-risk category had 14 times the rate of major bleeding of those in the low-risk group (incidence rate ratio (IRR) 14; 95% confidence interval (CI), 1.9 to 104.7). The rate of major bleeding was significantly different between the high- and intermediate-risk categories (P<.001). Among those with atrial fibrillation, patients in the high-risk category had 6 times the major bleeding rate of those in the intermediate- and low-risk groups combined (IRR=6; 95% CI, 2.4 to 15.3). The BRI discriminates between high- and intermediate-risk patients in a VA anticoagulation clinic, including those with atrial fibrillation. JF - Journal of general internal medicine AU - Aspinall, Sherrie L AU - DeSanzo, Beth E AU - Trilli, Lauren E AU - Good, Chester B AD - Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA. sherrie.aspinall@med.va.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1008 EP - 1013 VL - 20 IS - 11 KW - Anticoagulants KW - 0 KW - Warfarin KW - 5Q7ZVV76EI KW - Index Medicus KW - Sensitivity and Specificity KW - Risk Factors KW - Humans KW - Atrial Fibrillation -- drug therapy KW - Cohort Studies KW - Retrospective Studies KW - Aged KW - Poisson Distribution KW - Male KW - Female KW - Risk Assessment KW - Decision Support Techniques KW - Hemorrhage -- epidemiology KW - Anticoagulants -- adverse effects KW - Warfarin -- adverse effects KW - Hemorrhage -- prevention & control KW - Hemorrhage -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68837843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+general+internal+medicine&rft.atitle=Bleeding+Risk+Index+in+an+anticoagulation+clinic.+Assessment+by+indication+and+implications+for+care.&rft.au=Aspinall%2C+Sherrie+L%3BDeSanzo%2C+Beth+E%3BTrilli%2C+Lauren+E%3BGood%2C+Chester+B&rft.aulast=Aspinall&rft.aufirst=Sherrie&rft.date=2005-11-01&rft.volume=20&rft.issue=11&rft.spage=1008&rft.isbn=&rft.btitle=&rft.title=Journal+of+general+internal+medicine&rft.issn=1525-1497&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-04 N1 - Date created - 2005-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Med. 1989 Aug;87(2):144-52 [2787958] Am J Med. 1990 Nov;89(5):569-78 [2239976] Chest. 2001 Jan;119(1 Suppl):194S-206S [11157649] JAMA. 2002 Nov 20;288(19):2441-8 [12435257] Arch Intern Med. 2003 Apr 28;163(8):917-20 [12719200] Ann Intern Med. 2003 May 20;138(10):831-8 [12755555] Arch Intern Med. 2003 Jul 14;163(13):1580-6 [12860581] Ann Intern Med. 2003 Dec 16;139(12):1018-33 [14678922] Chest. 2004 Sep;126(3 Suppl):287S-310S [15383476] Am J Gastroenterol. 1995 Feb;90(2):206-10 [7847286] Am Heart J. 1996 Nov;132(5):1095-100 [8892802] J Gen Intern Med. 1996 Dec;11(12):713-20 [9016417] J Gen Intern Med. 1996 Dec;11(12):721-8 [9016418] Am J Gastroenterol. 1997 Mar;92(3):419-24 [9068461] BMJ. 1997 May 24;314(7093):1529-30 [9183202] Am J Med. 1998 Aug;105(2):91-9 [9727814] Arch Intern Med. 1999 Mar 8;159(5):457-60 [10074953] Comment In: Evid Based Med. 2006 Aug;11(4):120 [17213133] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethnic disparities in the use of nicotine replacement therapy for smoking cessation in an equal access health care system. AN - 68802881; 16295702 AB - To examine ethnic variations in the use of nicotine replacement therapy (NRT) in an equal access health care system. Cross-sectional survey. Eighteen Veterans Affairs medical and ambulatory care centers. A cohort of male current smokers (n = 1606). Use of NRT (nicotine patch or nicotine gum), ethnicity, sociodemographics, health status, smoking-related history, and facility prescribing policy. Overall, only 34% of African-American and 26% of Hispanic smokers have ever used NRT as a cessation aid compared with 50% of white smokers. In the past year, African-American smokers were most likely to have attempted quitting. During a serious past-year quit attempt, however African-American and Hispanic smokers reported lower rates of NRT use than white smokers (20% vs. 22% vs. 34%, respectively, p = .001). In multivariate analyses, ethnicity was independently associated with NRT use during a past-year quit attempt. Compared with white smokers, African-American (adjusted odds ratio, .53; 95% confidence interval, .34-.83) and Hispanic (adjusted odds ratio, .55; 95% confidence interval, .28-1.08) smokers were less likely to use NRT. Assessment of variations in use of NRT demonstrates that African-American and Hispanic smokers are less likely to use NRT during quit attempts. Future research is needed on the relative contributions of patient, physician, and system features to gaps in guideline implementation to provide treatment for ethnic minority smokers. JF - American journal of health promotion : AJHP AU - Fu, Steven S AU - Sherman, Scott E AU - Yano, Elizabeth M AU - van Ryn, Michelle AU - Lanto, Andy B AU - Joseph, Anne M AD - Section of General Internal Medicine, Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA. Steven.Fu@med.va.gov PY - 2005 SP - 108 EP - 116 VL - 20 IS - 2 SN - 0890-1171, 0890-1171 KW - Health technology assessment KW - Cross-Sectional Studies KW - Humans KW - Cohort Studies KW - Aged KW - Middle Aged KW - Ambulatory Care Facilities KW - Male KW - Ethnic Groups KW - Tobacco Use Disorder -- therapy KW - Smoking Cessation -- methods KW - Health Services Accessibility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68802881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health+promotion+%3A+AJHP&rft.atitle=Ethnic+disparities+in+the+use+of+nicotine+replacement+therapy+for+smoking+cessation+in+an+equal+access+health+care+system.&rft.au=Fu%2C+Steven+S%3BSherman%2C+Scott+E%3BYano%2C+Elizabeth+M%3Bvan+Ryn%2C+Michelle%3BLanto%2C+Andy+B%3BJoseph%2C+Anne+M&rft.aulast=Fu&rft.aufirst=Steven&rft.date=2005-11-01&rft.volume=20&rft.issue=2&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health+promotion+%3A+AJHP&rft.issn=08901171&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-09 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effects of diseases, drugs, and chemicals on the creativity and productivity of famous sculptors, classic painters, classic music composers, and authors. AN - 68738045; 16253027 AB - Many myths, theories, and speculations exist as to the exact etiology of the diseases, drugs, and chemicals that affected the creativity and productivity of famous sculptors, classic painters, classic music composers, and authors. To emphasize the importance of a modern clinical chemistry laboratory and hematology coagulation laboratory in interpreting the basis for the creativity and productivity of various artists. This investigation analyzed the lives of famous artists, including classical sculptor Benvenuto Cellini; classical sculptor and painter Michelangelo Buonarroti; classic painters Ivar Arosenius, Edvard Munch, and Vincent Van Gogh; classic music composer Louis Hector Berlioz; and English essayist Thomas De Quincey. The analysis includes their illnesses, their famous artistic works, and the modern clinical chemistry, toxicology, and hematology coagulation tests that would have been important in the diagnosis and treatment of their diseases. The associations between illness and art may be close and many because of both the actual physical limitations of the artists and their mental adaptation to disease. Although they were ill, many continued to be productive. If modern clinical chemistry, toxicology, and hematology coagulation laboratories had existed during the lifetimes of these various well-known individuals, clinical laboratories might have unraveled the mysteries of their afflictions. The illnesses these people endured probably could have been ascertained and perhaps treated. Diseases, drugs, and chemicals may have influenced their creativity and productivity. JF - Archives of pathology & laboratory medicine AU - Wolf, Paul L AD - Department of Pathology and Laboratory Medicine, University of California, VA Medical Center, San Diego, CA 92103, USA. paul.wolf@med.va.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1457 EP - 1464 VL - 129 IS - 11 KW - Xenobiotics KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Efficiency KW - History, 20th Century KW - Hematologic Tests -- history KW - Toxicology -- history KW - Chemistry, Clinical -- history KW - History, 18th Century KW - History, 15th Century KW - History, 19th Century KW - History, 16th Century KW - Disease -- etiology KW - Drug-Related Side Effects and Adverse Reactions KW - Famous Persons KW - Disease -- psychology KW - Xenobiotics -- adverse effects KW - Creativity KW - Humanities -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68738045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+pathology+%26+laboratory+medicine&rft.atitle=The+effects+of+diseases%2C+drugs%2C+and+chemicals+on+the+creativity+and+productivity+of+famous+sculptors%2C+classic+painters%2C+classic+music+composers%2C+and+authors.&rft.au=Wolf%2C+Paul+L&rft.aulast=Wolf&rft.aufirst=Paul&rft.date=2005-11-01&rft.volume=129&rft.issue=11&rft.spage=1457&rft.isbn=&rft.btitle=&rft.title=Archives+of+pathology+%26+laboratory+medicine&rft.issn=1543-2165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Family history of suicide, female sex, and childhood trauma: separate or interacting risk factors for attempts at suicide? AN - 68688035; 16223424 AB - Female sex, childhood trauma, and a family history of suicidal behavior are three well established risk factors for attempting suicide. However, interactions between these three factors in attempting suicide have been little studied. One thousand eight hundred and eighty-nine abstinent substance dependent patients were interviewed about their lifetime and family history of suicidal behavior and completed the Childhood Trauma Questionnaire (CTQ). Gender, family history of suicidal behavior, and CTQ scores--and their interaction--were examined in relation to suicidal behavior. Each of the three risk factors was associated with at least a doubling of the risk for an attempt at suicide. There were no significant interactions in relation to the risk of making an attempt. However, female sex and higher levels of childhood trauma each discriminated patients at risk for both a younger age of first attempting suicide and for making more attempts. Female sex, childhood trauma, and a family history of suicidal behavior are each independent, and non-interacting, risk factors for attempting suicide. Additionally, female sex and high childhood trauma are independent risk factors for both an early onset of first attempting suicide and for making more attempts. JF - Acta psychiatrica Scandinavica AU - Roy, A AU - Janal, M AD - Psychiatry Service 116A, Department of Veterans Affairs, New Jersey Healthcare System, East Orange, NJ 07018, USA. alec.roy@med.va.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 367 EP - 371 VL - 112 IS - 5 SN - 0001-690X, 0001-690X KW - Index Medicus KW - Pedigree KW - Cross-Sectional Studies KW - Sex Factors KW - Risk Factors KW - Humans KW - Adult KW - Child KW - Substance-Related Disorders -- psychology KW - Male KW - Female KW - Wounds and Injuries -- psychology KW - Child Abuse -- psychology KW - Suicide, Attempted -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68688035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+psychiatrica+Scandinavica&rft.atitle=Family+history+of+suicide%2C+female+sex%2C+and+childhood+trauma%3A+separate+or+interacting+risk+factors+for+attempts+at+suicide%3F&rft.au=Roy%2C+A%3BJanal%2C+M&rft.aulast=Roy&rft.aufirst=A&rft.date=2005-11-01&rft.volume=112&rft.issue=5&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Acta+psychiatrica+Scandinavica&rft.issn=0001690X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-10-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Safety of Outpatient Dalteparin Therapy in Veterans with Mechanical Heart Valves AN - 17137485; 6784270 AB - To determine the rate of bleeding and thromboembolic events within 1 month of outpatient dalteparin therapy in veterans with mechanical heart valves, to evaluate potential risk factors associated with these events, and to examine the prescribing patterns of dalteparin in this patient population. Single-center retrospective electronic chart review. Large, academically affiliated Veterans Affairs hospital. Thirty-eight men with mechanical heart valves who received outpatient prescriptions for dalteparin from October 1, 1998-June 30, 2003. Charts were reviewed for thromboembolic and bleeding events. Demographic, clinical, and drug utilization variables were assessed. The associations of adverse events with potential risk factors, indication for dalteparin therapy, and prescribing clinic were analyzed. Sixty-four dalteparin regimens were evaluated. No thromboembolic events were reported in any case within 1 month after receiving dalteparin for thromboembolic prophylaxis during warfarin interruption for periprocedural anticoagulation or for anticoagulation during an unintentional subtherapeutic international normalized ratio. Bleeding events occurred in 15 (23%) of the 64 regimens. Most bleeding events resolved spontaneously and without intervention. No potential risk factors for bleeding were identified. Dalteparin appeared to be a safe, effective means of short-term thromboembolic prophylaxis in this population of ambulatory male veterans with mechanical heart valves. Large, randomized, controlled, prospective trials are warranted. JF - Pharmacotherapy AU - O'Neill, J L AU - Flanagan, P S AU - Zaleon, C R AU - Copeland, LA AD - Veterans Affairs Ann Arbor Healthcare System, 2215 Fuller Road (119), Ann Arbor, MI 48105, USA, Jessica.Oneill@med.va.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 1560 EP - 1565 VL - 25 IS - 11 SN - 0277-0008, 0277-0008 KW - dalteparin KW - Health & Safety Science Abstracts KW - Cardiovascular system KW - Reviews KW - Drugs KW - Side effects KW - Thromboembolism KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17137485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Safety+of+Outpatient+Dalteparin+Therapy+in+Veterans+with+Mechanical+Heart+Valves&rft.au=O%27Neill%2C+J+L%3BFlanagan%2C+P+S%3BZaleon%2C+C+R%3BCopeland%2C+LA&rft.aulast=O%27Neill&rft.aufirst=J&rft.date=2005-11-01&rft.volume=25&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Archives+of+Environmental+Health&rft.issn=00039896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cardiovascular system; Reviews; Drugs; Thromboembolism; Side effects ER - TY - JOUR T1 - Speech recognition in multitalker babble using digits, words, and sentences. AN - 85396295; pmid-16515143 AB - The purpose of this mixed model design was to examine recognition performance differences when measuring speech recognition in multitalker babble on listeners with normal hearing (n = 36) and listeners with hearing loss (n = 72) utilizing stimulus of varying linguistic complexity (digits, words, and sentence materials). All listeners were administered two trials of two lists of each material in a descending speech-to-babble ratio. For each of the materials, recognition performances by the listeners with normal hearing were significantly better than the performances by the listeners with hearing loss. The mean separation between groups at the 50% point in signal-to-babble ratio on each of the three materials was approximately 8 dB. The 50% points for digits were obtained at a significantly lower signal-to-babble ratio than for sentences or words that were equivalent. There were no interlist differences between the two lists for the digits and words, but there was a significant disparity between QuickSIN lists for the listeners with hearing loss. A two-item questionnaire was used to obtain a subjective measurement of speech recognition, which showed moderate correlations with objective measures of speech recognition in noise using digits (r = .641), sentences (r = .572), and words (r = .673). JF - Journal of the American Academy of Audiology AU - McArdle, Rachel A AU - Wilson, Richard H AU - Burks, Christopher A AD - Bay Pines VA Healthcare System, Audiology (126), FL 33744, USA. Rachel.mcardle@med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 726 EP - 39; quiz 763-4 VL - 16 IS - 9 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Aged KW - Aged, 80 and over KW - Analysis of Variance KW - Audiometry, Speech KW - Case-Control Studies KW - *Hearing Loss, Sensorineural: physiopathology KW - Humans KW - Middle Aged KW - *Perceptual Masking: physiology KW - Psychometrics KW - *Speech Perception: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Speech+recognition+in+multitalker+babble+using+digits%2C+words%2C+and+sentences.&rft.au=McArdle%2C+Rachel+A%3BWilson%2C+Richard+H%3BBurks%2C+Christopher+A&rft.aulast=McArdle&rft.aufirst=Rachel&rft.date=2005-10-01&rft.volume=16&rft.issue=9&rft.spage=726&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Normative data for the Attitudes towards Loss of Hearing Questionnaire. AN - 85395730; pmid-16515136 AB - Investigations have shown that patient attitudes toward hearing loss and hearing aids impact self-reported handicap and disability, hearing aid benefit, and hearing aid use. The Attitudes towards Loss of Hearing Questionnaire (ALHQ) was developed by Saunders and Cienkowski (1996) to examine some of the psychosocial factors underlying the use and acquisition of hearing aids. Here we report data from a new version of questionnaire (ALHQ v2.1), which examines attitudes towards hearing loss and hearing aids on five scales: Denial of Hearing Loss, Negative Associations, Negative Coping Strategies, Manual Dexterity and Vision, and Hearing-Related Esteem. Reliability values, internal consistency values, and cut points for typical and atypical scores are provided, along with comparison of the scores of women, men, current hearing aid users, non-hearing aid users, and paying versus nonpaying individuals. The ALHQ takes about ten minutes to complete and identifies for the clinician some of the issues that might jeopardize successful hearing aid outcome. JF - Journal of the American Academy of Audiology AU - Saunders, Gabrielle H AU - Cienkowski, Kathleen M AU - Forsline, Anna AU - Fausti, Stephen AD - National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Oregon 97207, USA. Gabrielle.saunders@med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 637 EP - 652 VL - 16 IS - 9 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adaptation, Psychological KW - Aged KW - Aged, 80 and over KW - Analysis of Variance KW - Association KW - *Attitude to Health KW - Audiometry, Pure-Tone KW - Auditory Threshold KW - Denial (Psychology) KW - Female KW - *Hearing Aids: psychology KW - *Hearing Loss, Sensorineural: psychology KW - Humans KW - Linear Models KW - Male KW - Middle Aged KW - Motor Skills KW - Questionnaires: standards KW - Reference Values KW - Reproducibility of Results KW - Self Concept KW - Vision, Ocular UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85395730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Normative+data+for+the+Attitudes+towards+Loss+of+Hearing+Questionnaire.&rft.au=Saunders%2C+Gabrielle+H%3BCienkowski%2C+Kathleen+M%3BForsline%2C+Anna%3BFausti%2C+Stephen&rft.aulast=Saunders&rft.aufirst=Gabrielle&rft.date=2005-10-01&rft.volume=16&rft.issue=9&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Alterations of striatal neurons in benign hereditary chorea. AN - 85394809; pmid-15986422 AB - Benign hereditary chorea (BHC) recently has been associated with mutations in TITF-1 gene, although a pathological study of an individual with BHC and a TITF-1 mutation revealed no significant gross or microscopic abnormalities using standard methods. Immunohistochemical staining of striatal tissue from a BHC-affected postmortem brain was performed using antibodies against neurotransmitters of interneurons whose tangential migration is mediated by TITF-1. There was a loss of most TITF-1-mediated striatal interneurons in the BHC specimen compared to four matched control brains.Copyright (c) 2005 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Kleiner-Fisman, Galit AU - Calingasan, Noel Y AU - Putt, Mary AU - Chen, June AU - Beal, M Flint AU - Lang, Anthony E AD - Parkinson's Disease Research, Education and Clinical Center (PADRECC), Philadelphia VA Hospital, Philadelphia, Pennsylvania 19104, USA. galit.kleiner-fisman@med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 1353 EP - 1357 VL - 20 IS - 10 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Antibodies: immunology KW - Cell Movement KW - Chorea: genetics KW - Chorea: metabolism KW - *Chorea: pathology KW - Chromosomes, Human, Pair 14: genetics KW - Corpus Striatum: metabolism KW - *Corpus Striatum: pathology KW - Fatal Outcome KW - Humans KW - Immunohistochemistry KW - Interneurons: immunology KW - Interneurons: metabolism KW - Interneurons: pathology KW - Middle Aged KW - Neurons: metabolism KW - *Neurons: pathology KW - Neurotransmitter Agents: immunology KW - Nuclear Proteins: genetics KW - Nuclear Proteins: metabolism KW - Point Mutation: genetics KW - Transcription Factors: genetics KW - Transcription Factors: metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85394809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Alterations+of+striatal+neurons+in+benign+hereditary+chorea.&rft.au=Kleiner-Fisman%2C+Galit%3BCalingasan%2C+Noel+Y%3BPutt%2C+Mary%3BChen%2C+June%3BBeal%2C+M+Flint%3BLang%2C+Anthony+E&rft.aulast=Kleiner-Fisman&rft.aufirst=Galit&rft.date=2005-10-01&rft.volume=20&rft.issue=10&rft.spage=1353&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Combination docetaxel plus vitamin D(3) as an immune therapy in animals bearing squamous cell carcinomas. AN - 85394730; pmid-16213938 AB - Background tumor growth results in the mobilization of immune inhibitory CD34(+) progenitor cells. However, vitamin D(3) can differentiate the CD34(+) cells into immune stimulatory dendritic cells. This study determined if docetaxel treatment could increase the impact of the vitamin D(3) to generate dendritic cells.The murine squamous cell carcinoma model, SCC VII/SF, which is often used as a head and neck cancer model, was used to determine the immunological effects of two cycles of docetaxel plus vitamin D(3).Vitamin D(3) with or without docetaxel was similarly effective in reducing CD34(+) cell levels within the spleen, lymph nodes, and tumor. Dendritic cell levels were similarly enhanced in the lymph nodes by vitamin D(3) alone or combined with docetaxel. However, the combination treatment caused a prominent increase in intratumoral levels of active T cells, which was not observed by the individual treatments.Incorporating docetaxel treatment with vitamin D(3) differentiation-inducing treatment enhances intratumoral immune responsiveness. JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery AU - Young, M Rita I AU - Lathers, Deanne M R AD - Department of Research Services, Ralph H. Johnson V.A. Medical Center, Charleston, South Carolina 29401, USA. rita.young@med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 611 EP - 618 VL - 133 IS - 4 SN - 0194-5998, 0194-5998 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Antigens, CD: metabolism KW - *Antineoplastic Agents, Phytogenic: administration & dosage KW - *Carcinoma, Squamous Cell: drug therapy KW - Carcinoma, Squamous Cell: metabolism KW - Carcinoma, Squamous Cell: pathology KW - Cell Count KW - *Cholecalciferol: administration & dosage KW - Dendritic Cells KW - Disease Models, Animal KW - Drug Therapy, Combination KW - Interferon-gamma: metabolism KW - Lymph Nodes: metabolism KW - Lymph Nodes: pathology KW - Mice KW - Spleen: metabolism KW - Spleen: pathology KW - Stem Cells KW - T-Lymphocytes KW - *Taxoids: administration & dosage KW - *Vitamins: administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85394730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=Combination+docetaxel+plus+vitamin+D%283%29+as+an+immune+therapy+in+animals+bearing+squamous+cell+carcinomas.&rft.au=Young%2C+M+Rita+I%3BLathers%2C+Deanne+M+R&rft.aulast=Young&rft.aufirst=M+Rita&rft.date=2005-10-01&rft.volume=133&rft.issue=4&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - General review of tinnitus: prevalence, mechanisms, effects, and management. AN - 85389512; pmid-16411806 AB - Tinnitus is an increasing health concern across all strata of the general population. Although an abundant amount of literature has addressed the many facets of tinnitus, wide-ranging differences in professional beliefs and attitudes persist concerning its clinical management. These differences are detrimental to tinnitus patients because the management they receive is based primarily on individual opinion (which can be biased) rather than on medical consensus. It is thus vitally important for the tinnitus professional community to work together to achieve consensus. To that end, this article provides a broad-based review of what is presently known about tinnitus, including prevalence, associated factors, theories of pathophysiology, psychological effects, effects on disability and handicap, workers' compensation issues, clinical assessment, and various forms of treatment. This summary of fundamental information has relevance to both clinical and research arenas. JF - Journal of speech, language, and hearing research : JSLHR AU - Henry, James A AU - Dennis, Kyle C AU - Schechter, Martin A AD - Veterans Affairs Medical Center, Portland, OR 97207, USA. james.henry@med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 1204 EP - 1235 VL - 48 IS - 5 SN - 1092-4388, 1092-4388 KW - Index Medicus KW - National Library of Medicine KW - Adaptation, Psychological KW - *Auditory Pathways: physiopathology KW - Disability Evaluation KW - Hearing Disorders: economics KW - *Hearing Disorders: etiology KW - Humans KW - Prevalence KW - Quality of Life KW - Questionnaires KW - Risk Factors KW - Sickness Impact Profile KW - Tinnitus: epidemiology KW - Tinnitus: etiology KW - Tinnitus: psychology KW - Tinnitus: therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85389512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.atitle=General+review+of+tinnitus%3A+prevalence%2C+mechanisms%2C+effects%2C+and+management.&rft.au=Henry%2C+James+A%3BDennis%2C+Kyle+C%3BSchechter%2C+Martin+A&rft.aulast=Henry&rft.aufirst=James&rft.date=2005-10-01&rft.volume=48&rft.issue=5&rft.spage=1204&rft.isbn=&rft.btitle=&rft.title=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.issn=10924388&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Mitigating cutaneous side effects of lamotrigine. AN - 68821262; 16297026 JF - Perspectives in psychiatric care AU - Antai-Otong, Deborah AD - deborah.antai-otong@med.va.gov PY - 2005 SP - 193 EP - 196 VL - 41 IS - 4 SN - 0031-5990, 0031-5990 KW - Antimanic Agents KW - 0 KW - Triazines KW - lamotrigine KW - U3H27498KS KW - Nursing KW - Humans KW - Stevens-Johnson Syndrome -- chemically induced KW - Bipolar Disorder -- drug therapy KW - Antimanic Agents -- adverse effects KW - Antimanic Agents -- therapeutic use KW - Exanthema -- chemically induced KW - Triazines -- adverse effects KW - Triazines -- therapeutic use KW - Drug Prescriptions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68821262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+in+psychiatric+care&rft.atitle=Mitigating+cutaneous+side+effects+of+lamotrigine.&rft.au=Antai-Otong%2C+Deborah&rft.aulast=Antai-Otong&rft.aufirst=Deborah&rft.date=2005-10-01&rft.volume=41&rft.issue=4&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Perspectives+in+psychiatric+care&rft.issn=00315990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-15 N1 - Date created - 2005-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition. AN - 68756057; 16266282 AB - This review will focus primarily on the role of the low density lipoprotein receptor-related protein (LRP-1) in neuronal synapse formation and function in Alzheimer's Disease (AD). We review the role that its ligands may have in cognition or AD: apolipoprotein E (ApoE), alpha2-macroglobulin, Transforming Growth Factor-Beta (TGFbeta, Tissue Plasminogen Activator (tPA), insulin growth factor binding protein-3 (IGFBP-3), which all bind LRP-1 and apolipoprotein J (ApoJ), which is a ligand for LRP-2. After reviewing its role as a signaling receptor, we discuss the connection between LRP and the NMDA glutamate receptor via the post synaptic density 95 (PSD-95) neuronal scaffold protein and the implications it may have for memory and cognition. Finally, we discuss the evidence supporting a role for LRP in AD. Although the evidence for LRP as a genetic risk factor is weak, many of its ligands impose genetic risk, and have been implicated in AD pathogenic cascades. We discuss the role of LRP in amyloid precursor protein (APP) processing and production of beta-amyloid (Abeta. We identify LRP ligands that accelerate aggregation of toxic Abeta species. LRP mediates crucial pathways in AD pathogenesis such as Abeta clearance, Abeta uptake, intraneuronal Abeta accumulation and Abeta-associated neuron death. Interestingly, the TGFbeta -V receptor is LRP-1. Data show that one critical ligand TGFbeta2, associated with neurodegeneration in amyloid diseases, induces LRP expression in PC12 cells. Data from rodent infusion models demonstrate the impact of TGFbeta2 in modifying Abeta- induced Long Term Potentiation (LTP) responses, presynaptic proteins, lipid peroxidation, gliosis and staining for neuronal nuclei. The evidence supports a complex and significant role of LRP in cognition and AD. JF - Current drug targets. CNS and neurological disorders AU - Harris-White, M E AU - Frautschy, S A AD - University of California, Los Angeles, Department of Medicine, and the Veterans Administration Greater Los Angeles Healthcare System, Sepulveda 91343, USA. marni@ucla.edu Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 469 EP - 480 VL - 4 IS - 5 SN - 1568-007X, 1568-007X KW - Amyloid beta-Peptides KW - 0 KW - LDL-Receptor Related Proteins KW - Ligands KW - Receptors, N-Methyl-D-Aspartate KW - Index Medicus KW - Signal Transduction -- physiology KW - Animals KW - Humans KW - Mice KW - Receptors, N-Methyl-D-Aspartate -- metabolism KW - Mice, Knockout KW - Cognition -- physiology KW - Neurons -- metabolism KW - Amyloid beta-Peptides -- metabolism KW - Alzheimer Disease -- metabolism KW - LDL-Receptor Related Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68756057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+targets.+CNS+and+neurological+disorders&rft.atitle=Low+density+lipoprotein+receptor-related+proteins+%28LRPs%29%2C+Alzheimer%27s+and+cognition.&rft.au=Harris-White%2C+M+E%3BFrautschy%2C+S+A&rft.aulast=Harris-White&rft.aufirst=M&rft.date=2005-10-01&rft.volume=4&rft.issue=5&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Current+drug+targets.+CNS+and+neurological+disorders&rft.issn=1568007X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-23 N1 - Date created - 2005-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relative prevalence of comorbidities and treatment contraindications in HIV-mono-infected and HIV/HCV-co-infected veterans. AN - 68736602; 16251836 AB - To determine the prevalence of hepatitis C virus (HCV) co-infection among HIV-infected veterans, assess the prevalence of comorbid conditions that may complicate or limit treatment options, and ascertain whether comorbid conditions were more common in co-infected veterans. We used the Veterans Administration electronic medical records system to identify all veterans receiving care for HIV during fiscal years 1997-2002. Demographic data and diagnostic codes for HIV, HCV, and comorbid conditions were extracted. The validity of using diagnostic codes was assessed by calculating the agreement between chart extraction and electronic data on a separate sample of veterans. Factor analysis was used to identify the structure underlying the intercorrelation between comorbid conditions. Logistic regression was used to compare the prevalence of comorbid conditions and factors between HIV/HCV-co-infected and HIV-mono-infected veterans, adjusting for age and race. We identified 25,116 HIV-infected veterans in care, of whom 4489 (18%) were HCV co-infected. A validity assessment revealed moderate agreement between chart extraction and electronic data for each of the comorbid conditions assessed. HIV/HCV-co-infected veterans were significantly more likely to have each of the comorbid conditions, and to have significantly more comorbid conditions. Factor analysis revealed three dimensions of comorbidity: mental disorders, medical disorders, and alcohol-related complications. Veterans with co-infection were significantly more likely to have mental disorders and alcohol-related complications. HIV/HCV-co-infected veterans had a higher prevalence of comorbid conditions that may complicate and limit treatment options for HIV and for HCV co-infection. Strategies to improve treatment options for co-infected patients with comorbidities must be developed. JF - AIDS (London, England) AU - Goulet, Joseph L AU - Fultz, Shawn L AU - McGinnis, Kathleen A AU - Justice, Amy C AD - Yale University School of Medicine, New Haven, CT, USA. joseph.goulet@med.va.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - S99 EP - 105 VL - 19 Suppl 3 SN - 0269-9370, 0269-9370 KW - Index Medicus KW - AIDS/HIV KW - Epidemiologic Methods KW - Aged, 80 and over KW - Mental Disorders -- epidemiology KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Comorbidity KW - Substance-Related Disorders -- epidemiology KW - Veterans -- statistics & numerical data KW - Hepatitis C -- epidemiology KW - HIV Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68736602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Relative+prevalence+of+comorbidities+and+treatment+contraindications+in+HIV-mono-infected+and+HIV%2FHCV-co-infected+veterans.&rft.au=Goulet%2C+Joseph+L%3BFultz%2C+Shawn+L%3BMcGinnis%2C+Kathleen+A%3BJustice%2C+Amy+C&rft.aulast=Goulet&rft.aufirst=Joseph&rft.date=2005-10-01&rft.volume=19+Suppl+3&rft.issue=&rft.spage=S99&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-29 N1 - Date created - 2005-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alfuzosin for treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia: a systematic review of efficacy and adverse effects. AN - 68704102; 16230138 AB - To evaluate the efficacy and adverse effects of alfuzosin for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH). The included studies were randomized controlled trials involving men with symptomatic BPH treated with alfuzosin versus placebo or active control for at least 4 weeks. The search strategy identified 11 trials involving 3901 men with a mean age of 64 years. Eight trials were placebo-controlled studies, two were alfuzosin versus alternative alpha-blockers, and one was alfuzosin versus finasteride and combination alfuzosin/finasteride therapy. The study durations were short term, 4 to 26 weeks. The mean baseline symptom scores and peak urinary flow rates were indicative of moderate BPH. Alfuzosin (7.5 or 10 mg) improved lower urinary tract symptoms assessed by the International Prostate Symptom Score compared with placebo. The mean absolute change from baseline was -5.4 points for alfuzosin compared with -3.6 points for placebo, a weighted mean difference of 1.8 points (three studies). Alfuzosin increased the peak urinary flow more than did placebo, although the improvement varied across the eight studies. Symptom and flow improvements were generally comparable to that with combination therapy and with other alpha1-blockers. Alfuzosin had good short-term tolerability, and the numbers of study withdrawals were comparable to those with placebo and controls. Efficacy and short-term safety were similar across the various (immediate-release, sustained, and once-daily) formulations. The results from short-term studies have indicated that alfuzosin improves lower urinary tract symptoms and urinary flow more than does placebo and is generally well tolerated in men with symptomatic BPH. Long-term efficacy and safety studies in combination with a 5-alpha-reductase inhibitor should be initiated. JF - Urology AU - MacDonald, Roderick AU - Wilt, Timothy J AD - Minneapolis Veterans Affairs Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA. Roderick.MacDonald@med.va.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 780 EP - 788 VL - 66 IS - 4 KW - Adrenergic alpha-Antagonists KW - 0 KW - Quinazolines KW - alfuzosin KW - 90347YTW5F KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Humans KW - Male KW - Prostatic Hyperplasia -- drug therapy KW - Adrenergic alpha-Antagonists -- therapeutic use KW - Urination Disorders -- drug therapy KW - Urination Disorders -- etiology KW - Quinazolines -- therapeutic use KW - Quinazolines -- adverse effects KW - Adrenergic alpha-Antagonists -- adverse effects KW - Prostatic Hyperplasia -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68704102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Urology&rft.atitle=Alfuzosin+for+treatment+of+lower+urinary+tract+symptoms+compatible+with+benign+prostatic+hyperplasia%3A+a+systematic+review+of+efficacy+and+adverse+effects.&rft.au=MacDonald%2C+Roderick%3BWilt%2C+Timothy+J&rft.aulast=MacDonald&rft.aufirst=Roderick&rft.date=2005-10-01&rft.volume=66&rft.issue=4&rft.spage=780&rft.isbn=&rft.btitle=&rft.title=Urology&rft.issn=1527-9995&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-28 N1 - Date created - 2005-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Training psychiatrists to diagnose and treat substance abuse disorders. AN - 68684657; 16216153 AB - Addiction training in psychiatric residency programs needs expansion. Epidemiology research has shown that patients with substance use disorders and co-occurring mental health disorders are the norm in nearly all clinical settings. Unfortunately, traditional training approaches built around brief rotations on detoxification or intensive substance abuse rehabilitation units do not adequately train psychiatrists in long-term management skills, and may reinforce misperceptions that these patients do not respond to treatment. An enhanced addiction curriculum coupled with an extended outpatient clinic rotation is an ideal model for teaching the skills needed to successfully care for these patients. Training must include an adequate knowledge base, an opportunity to cultivate positive attitudes toward these patients, and recognition that psychiatrists must take responsibility for treating the addiction problem and any co-occurring psychiatric disorders. The program developed at Boston University Medical Center successfully integrates expanded addiction psychiatry training into the general psychiatry residency. JF - Current psychiatry reports AU - Renner, John A AU - Quinones, Janice AU - Wilson, Amanda AD - VA Outpatient Clinic, 251 Causeway Street, Boston, MA 02114, USA. john.renner@med.va.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 352 EP - 359 VL - 7 IS - 5 SN - 1523-3812, 1523-3812 KW - Index Medicus KW - Outpatients KW - Diagnosis, Differential KW - Humans KW - Curriculum KW - Health Knowledge, Attitudes, Practice KW - Professional Competence KW - Substance-Related Disorders -- diagnosis KW - Internship and Residency KW - Psychiatry -- education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68684657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+psychiatry+reports&rft.atitle=Training+psychiatrists+to+diagnose+and+treat+substance+abuse+disorders.&rft.au=Renner%2C+John+A%3BQuinones%2C+Janice%3BWilson%2C+Amanda&rft.aulast=Renner&rft.aufirst=John&rft.date=2005-10-01&rft.volume=7&rft.issue=5&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Current+psychiatry+reports&rft.issn=15233812&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pulse versus continuous terbinafine for onychomycosis: a randomized, double-blind, controlled trial. AN - 68644505; 16198776 AB - Effective treatments for onychomycosis are expensive. Previous studies suggest that less costly, pulsed doses of antifungal medications may be as effective as standard, continuous doses. Terbinafine is the current treatment of choice for toenail onychomycosis. Our purpose was to determine whether pulse-dose terbinafine is as effective as standard continuous-dose terbinafine for treatment of toenail onychomycosis. We conducted a double-blind, randomized, noninferiority, clinical intervention trial in the Minneapolis Veterans Affairs Medical Center. The main inclusion criteria for participants were a positive dermatophyte culture and at least 25% distal subungual clinical involvement. Six hundred eighteen volunteers were screened; 306 were randomized. Terbinafine, 250 mg daily for 3 months (continuous) or terbinafine, 500 mg daily for 1 week per month for 3 months (pulse) was administered. The primary outcome measure was mycological cure of the target toenail at 18 months. Secondary outcome measures included clinical cure and complete (clinical plus mycological) cure of the target toenail and complete cure of all 10 toenails. Results of an intent-to-treat analysis did not meet the prespecified criterion for noninferiority but did demonstrate the superiority of continuous-dose terbinafine for: mycological cure of the target toenail (70.9% [105/148] vs 58.7% [84/143]; P =.03, relative risk [RR] of 1.21 [95% confidence interval (CI), 1.02-1.43]); clinical cure of the target toenail (44.6% [66/148] vs 29.3% [42/143]; P =.007, RR =1.52 [95% CI, 1.11-2.07); complete cure of the target toenail (40.5% [60/148] vs 28.0% [40/143]; P =.02, RR=1.45 [95% CI, 1.04-2.01); and complete cure of all 10 toenails (25.2% [36/143] vs 14.7% [21/143]; P =.03, RR =1.71 [95% CI, 1.05-2.79). Tolerability of the regimens did not differ significantly between the groups (chi2 =1.63; P =.65). The study population primarily consisted of older men with severe onychomycosis. This study demonstrated the superiority of continuous- over pulse-dose terbinafine. We also found this expensive therapy to be much less effective than previously believed, particularly for achieving complete cure of all 10 toenails. JF - Journal of the American Academy of Dermatology AU - Warshaw, Erin M AU - Fett, Debra D AU - Bloomfield, Hanna E AU - Grill, Joseph P AU - Nelson, David B AU - Quintero, Vicente AU - Carver, Susan M AU - Zielke, Gary R AU - Lederle, Frank A AD - Center for Chronic Disease Outcomes Research, Minneapolis, Minnesota, USA. erin.warshaw@med.va.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 578 EP - 584 VL - 53 IS - 4 KW - Antifungal Agents KW - 0 KW - Naphthalenes KW - Tablets KW - terbinafine KW - G7RIW8S0XP KW - Index Medicus KW - Pulse Therapy, Drug KW - Double-Blind Method KW - Humans KW - Treatment Outcome KW - Aged KW - Foot Dermatoses -- drug therapy KW - Male KW - Female KW - Antifungal Agents -- adverse effects KW - Naphthalenes -- administration & dosage KW - Naphthalenes -- adverse effects KW - Antifungal Agents -- administration & dosage KW - Onychomycosis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68644505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Pulse+versus+continuous+terbinafine+for+onychomycosis%3A+a+randomized%2C+double-blind%2C+controlled+trial.&rft.au=Warshaw%2C+Erin+M%3BFett%2C+Debra+D%3BBloomfield%2C+Hanna+E%3BGrill%2C+Joseph+P%3BNelson%2C+David+B%3BQuintero%2C+Vicente%3BCarver%2C+Susan+M%3BZielke%2C+Gary+R%3BLederle%2C+Frank+A&rft.aulast=Warshaw&rft.aufirst=Erin&rft.date=2005-10-01&rft.volume=53&rft.issue=4&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=1097-6787&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-10 N1 - Date created - 2005-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prescriptions for chronic high-dose cyclooxygenase-2 inhibitors are often inappropriate and potentially dangerous. AN - 68644370; 16191131 AB - To describe the use of coxibs outside of licensed indications and recommended dosing ranges including rofecoxib 50 mg, valdecoxib 20 to 40 mg, and celecoxib 400 mg. Cross-sectional study of coxib utilization in 2002 and 2003 and retrospective cohort analysis of new users. Patients with known age and sex enrolled in Tennessee's Medicaid program. The prevalence of coxib use by dose and duration, and the proportion of persons initially prescribed a high-dose coxib and indications for such use. The estimated daily prevalence of nonaspirin prescription nonsteroidal anti-inflammatory drugs (NSAIDs) was 8.7% in 2002 to 2003 (45.7% coxibs). NSAID use peaked at age 65 to 74 with a prevalence of 19.8% (56.3% coxibs). Doses above the recommended daily dose for osteoarthritis accounted for 33.2% (95% confidence intervals [CIs] 32.4%, 33.9%) of celecoxib use, 14.9% (95% CI 14.4%, 15.5%) of rofecoxib use, and 52.2% (95% CI 50.6%, 53.8%) of valdecoxib use. Most of these prescriptions were for a month's supply. For new coxib users, 13.5% were given a month's supply for the highest dose category, and 28% refilled their prescriptions within 7 days of the end of the original prescription. Of these new chronic high-dose users, 17.2% had ischemic heart disease and 7.1% had heart failure. A substantial portion of coxib prescriptions were for a month's supply at doses above those recommended for most chronic indications. New users were also prescribed high doses despite evidence for cardiovascular comorbidity. These prescribing patterns at doses outside licensed indications are both inappropriate and potentially dangerous. JF - Journal of general internal medicine AU - Roumie, Christianne L AU - Arbogast, Patrick G AU - Mitchel, Edward F AU - Griffin, Marie R AD - Veterans Administration, Tennessee Valley Healthcare System, Tennessee Valley Geriatric Research Education Clinical Center (GRECC), Nashville, Tenn 37212, USA. christianne.roumie@vanderbilt.edu Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 879 EP - 883 VL - 20 IS - 10 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase Inhibitors KW - Index Medicus KW - United States KW - Reproducibility of Results KW - Humans KW - Osteoarthritis -- drug therapy KW - Tennessee KW - Medicaid KW - Male KW - Female KW - Cyclooxygenase Inhibitors -- adverse effects KW - Drug Prescriptions -- standards KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Chronic Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68644370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+general+internal+medicine&rft.atitle=Prescriptions+for+chronic+high-dose+cyclooxygenase-2+inhibitors+are+often+inappropriate+and+potentially+dangerous.&rft.au=Roumie%2C+Christianne+L%3BArbogast%2C+Patrick+G%3BMitchel%2C+Edward+F%3BGriffin%2C+Marie+R&rft.aulast=Roumie&rft.aufirst=Christianne&rft.date=2005-10-01&rft.volume=20&rft.issue=10&rft.spage=879&rft.isbn=&rft.btitle=&rft.title=Journal+of+general+internal+medicine&rft.issn=1525-1497&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-01 N1 - Date created - 2005-09-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2005 Mar 17;352(11):1071-80 [15713944] N Engl J Med. 2005 Mar 17;352(11):1092-102 [15713943] Clin Ther. 1999 Oct;21(10):1688-702 [10566565] JAMA. 1999 Nov 24;282(20):1921-8 [10580457] N Engl J Med. 2000 Nov 23;343(21):1520-8, 2 p following 1528 [11087881] JAMA. 2001 Aug 22-29;286(8):954-9 [11509060] JAMA. 2002 Jul 17;288(3):321-33 [12117397] Lancet. 2002 Oct 5;360(9339):1071-3 [12383990] Am J Manag Care. 2002 Oct;8(15 Suppl):S392-400 [12416789] Lancet. 2002 Dec 14;360(9349):1903-13 [12493255] Pharmacoepidemiol Drug Saf. 2003 Jan-Feb;12(1):67-70 [12616850] J Thorac Cardiovasc Surg. 2003 Jun;125(6):1481-92 [12830070] Circulation. 2004 May 4;109(17):2068-73 [15096449] Pharmacoepidemiol Drug Saf. 2004 Jun;13(6):339-43 [15170762] N Engl J Med. 2004 Oct 21;351(17):1709-11 [15470192] N Engl J Med. 2004 Oct 21;351(17):1707-9 [15470193] Med Care. 1976 Feb;14(2):166-72 [768652] Ann Intern Med. 1988 Sep 1;109(5):359-63 [3261560] JAMA. 1998 Aug 19;280(7):605-13 [9718051] N Engl J Med. 1999 Sep 2;341(10):709-17 [10471456] N Engl J Med. 2005 Mar 17;352(11):1081-91 [15713945] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Challenges in the adoption of new pharmacotherapeutics for addiction to alcohol and other drugs. AN - 68619616; 16055196 AB - The adoption of pharmacotherapies for the treatment of alcohol and drug use disorders has progressed slowly despite the approval of new and effective medications. This paper begins with overviews of the prevalence of alcohol and drug abuse and dependence, the costs of addiction to the nation, and the value of treatment services. The role of pharmacotherapy in the treatment of addictive diseases is examined, and factors that affect the adoption and use of medications for alcohol and drug treatment are identified and discussed. Investigations that tested the effectiveness of buprenorphine for treatment of opioid dependence in new settings illustrate physician and counselor training and mentorship strategies that may promote the adoption of medications in the treatment of alcohol and drug use disorders. The paper concludes with a discussion of barriers and ways to surmount the barriers and to foster greater use of medications in alcohol and drug treatment. JF - Pharmacology & therapeutics AU - Saxon, Andrew J AU - McCarty, Dennis AD - Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98108, USA. andrew.saxon@med.va.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 119 EP - 128 VL - 108 IS - 1 SN - 0163-7258, 0163-7258 KW - Index Medicus KW - Alcoholism -- epidemiology KW - Alcoholism -- economics KW - Alcoholism -- drug therapy KW - Substance-Related Disorders -- drug therapy KW - Drug Therapy -- methods KW - Substance-Related Disorders -- economics KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68619616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+%26+therapeutics&rft.atitle=Challenges+in+the+adoption+of+new+pharmacotherapeutics+for+addiction+to+alcohol+and+other+drugs.&rft.au=Saxon%2C+Andrew+J%3BMcCarty%2C+Dennis&rft.aulast=Saxon&rft.aufirst=Andrew&rft.date=2005-10-01&rft.volume=108&rft.issue=1&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Pharmacology+%26+therapeutics&rft.issn=01637258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-05 N1 - Date created - 2005-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]. AN - 68591176; 16164626 AB - Excretion by the kidney of a variety of organic anionic drugs and metabolites is mediated by a family of multispecific organic anion transporters (OAT genes) that are part of the SLC22 family of solute carriers. Different OATs localize to the apical (OAT2, OAT4, and RST/URAT) or basolateral (OAT1/NKT and OAT3) membranes of the renal proximal tubule; the net transport of organic anions from blood to urine is believed to require both apical and basolateral OATs. These genes are also thought to mediate transport of organic anionic drugs and metabolites (e.g., urate) across choroid plexus, retina, placenta, and possibly olfactory mucosa. The extent of functional redundancy among OATs remains uncertain, but closely related OAT genes are tightly linked in the genome. Hence, a better understanding of human variation in organic anionic drug excretion may be obtained by studying OAT genes in combination rather than individually. We have analyzed single nucleotide polymorphisms (SNPs) in OAT1 (NKT), OAT2, OAT3, OAT4, and URAT1 (human homologue of RST) in an ethnically diverse sample of 96 individuals (192 haploid genomes). Ka/Ks analysis was also performed as well as haplotype reconstruction using the software program Arelquin. The data indicate that (1) nonsynonymous SNPs in OAT1 and OAT3 may not be frequent so it will be important to consider promoter region SNPs that regulate gene expression; (2) certain ethnic groups may have a high prevalence of nonsynonymous SNPs in particular OATs (e.g., OAT4 in Sub-Saharan Africans); (3) there are individuals who have nonsynonymous SNPs in apical and basolateral OATs; (4) nonsynonymous OAT4 SNPs may be more frequent, raising the possibility of altered maternofetal transport of drugs and metabolites; and (5) combinations of synonymous SNPs in OAT1 and OAT3 also occur in certain individuals. In addition, Ka/Ks analysis of human, chimp and rodent genes suggests that OAT4 is under accelerated selection pressure, perhaps reflecting specific human environmental exposures during evolution. In contrast, Ka/Ks analysis for URAT1 suggests decelerated selection pressure. Haplotype reconstruction also supports this view. Together, these data suggest that, in order to understand the effect of SNPs in genes of the SLC22 family on drug handling as well as excretion of metabolites like uric acid, it is important to consider the entire set of organic anion transporters. It will be particularly interesting to determine if individuals with nonsynonymous apical and basolateral SNPs have altered handling (and toxicity) of organic anionic drugs and metabolites. Certain OAT family members appear to be under greater evolutionary selection pressure. JF - Kidney international AU - Xu, Gang AU - Bhatnagar, Vibha AU - Wen, Gen AU - Hamilton, Bruce A AU - Eraly, Satish A AU - Nigam, Sanjay K AD - Department of Pediatrics, Family and Preventative Medicine and San Diego Veterans Administration Medical Center, University of California San Diego, La Jolla, California 92161, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1491 EP - 1499 VL - 68 IS - 4 SN - 0085-2538, 0085-2538 KW - Carrier Proteins KW - 0 KW - Organic Anion Transport Protein 1 KW - Organic Anion Transporters KW - Organic Anion Transporters, Sodium-Independent KW - Organic Cation Transport Proteins KW - SLC22A11 protein, human KW - SLC22A12 protein, human KW - SLC22A7 protein, human KW - organic anion transport protein 3 KW - Index Medicus KW - Organic Anion Transporters, Sodium-Independent -- genetics KW - Cell Polarity -- physiology KW - Organic Anion Transport Protein 1 -- genetics KW - Haplotypes KW - Humans KW - Carrier Proteins -- genetics KW - Polymorphism, Single Nucleotide KW - Organic Anion Transporters -- genetics KW - Kidney -- physiology KW - Kidney -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68591176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Analyses+of+coding+region+polymorphisms+in+apical+and+basolateral+human+organic+anion+transporter+%28OAT%29+genes+%5BOAT1+%28NKT%29%2C+OAT2%2C+OAT3%2C+OAT4%2C+URAT+%28RST%29%5D.&rft.au=Xu%2C+Gang%3BBhatnagar%2C+Vibha%3BWen%2C+Gen%3BHamilton%2C+Bruce+A%3BEraly%2C+Satish+A%3BNigam%2C+Sanjay+K&rft.aulast=Xu&rft.aufirst=Gang&rft.date=2005-10-01&rft.volume=68&rft.issue=4&rft.spage=1491&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-30 N1 - Date created - 2005-09-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of Trauma Exposure on Anger, Aggression, and Violence in a Nonclinical Sample of Men AN - 61299317; 200602236 AB - This study assessed the impact of traumatic exposure & posttraumatic stress disorder (PTSD) symptoms on anger, aggression, & violence among civilian male college Students. Results suggest that civilian men who have been exposed to a potentially traumatic event (PTE) & report symptoms of PTSD indicate more trait anger, more internal anger & hostility, & more aggression & violence than men who do not report symptoms of PTSD. Results are contrasted to those found in clinical samples of male veterans with PTSD & discussed in terms of understanding & treating anger & aggression in nonclinical, trauma-exposed populations. Tables, References. Adapted from the source document. JF - Violence and Victims AU - Jakupcak, Matthew AU - Tull, Matthew T AD - MIRECC, Veterans Affairs Puget Sound Health Care System, Seattle, WA matthew.jakupcak@med.va.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 589 EP - 598 PB - Springer Publishing Co., New York NY VL - 20 IS - 5 SN - 0886-6708, 0886-6708 KW - PTSD KW - anger KW - hostility KW - aggression KW - Veterans KW - Males KW - College Students KW - Posttraumatic Stress Disorder KW - Aggression KW - Violence KW - Anger KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61299317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Violence+and+Victims&rft.atitle=Effects+of+Trauma+Exposure+on+Anger%2C+Aggression%2C+and+Violence+in+a+Nonclinical+Sample+of+Men&rft.au=Jakupcak%2C+Matthew%3BTull%2C+Matthew+T&rft.aulast=Jakupcak&rft.aufirst=Matthew&rft.date=2005-10-01&rft.volume=20&rft.issue=5&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Violence+and+Victims&rft.issn=08866708&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-10-30 N1 - Number of references - 13 N1 - Last updated - 2016-09-28 N1 - CODEN - VIOVEI N1 - SubjectsTermNotLitGenreText - Anger; Males; Violence; Aggression; Posttraumatic Stress Disorder; Veterans; College Students ER - TY - JOUR T1 - An Evaluation of Cognitive Processing Therapy for the Treatment of Posttraumatic Stress Disorder Related to Childhood Sexual Abuse AN - 57171621; 200602518 AB - This study compared the effectiveness of cognitive processing therapy for sexual abuse survivors (CPT-SA) with that of the minimal attention (MA) given to a wait-listed control group. Seventy-one women were randomly assigned to 1 of the 2 groups. Participants were assessed at pretreatment & 3 times during posttreatment: immediately after treatment & at 3-month & 1-year follow-up, using the Clinician-Administered Posttraumatic Stress Disorder (PTSD) Scale (D. Blake et al., 1995), the Beck Depression Inventory (A. T. Beck, R. A. Steer, & G. K. Brown, 1996), the Structured Clinical Interview for the DSM-IV (R. L. Spitzer, J. B. W. Williams, & M. Gibbon, 1995; M. B. First et al., 1995), the Dissociative Experiences Scale-II (E. M. Bernstein & F. W. Putnam, 1986), & the Modified PTSD Symptom Scale (S. A. Falsetti, H. S. Resnick, P. A. Resick, & D. G. Kilpatrick, 1993). Analyses suggested that CPT-SA is more effective for reducing trauma-related symptoms than is MA, & the results were maintained for at least 1 year. 2 Tables, 42 References. [Copyright 2005 American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Chard, Kathleen M AD - Cincinati VA Medical Center, PTSD Division, Cincinnati, OH Kathleen.chard@med.va.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 965 EP - 971 VL - 73 IS - 5 SN - 0022-006X, 0022-006X KW - PTSD, child sexual abuse, cognitive therapy, trauma, treatment KW - Posttraumatic stress disorder KW - Women KW - Cognitive therapy KW - Childhood sexual abuse KW - Treatment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57171621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=An+Evaluation+of+Cognitive+Processing+Therapy+for+the+Treatment+of+Posttraumatic+Stress+Disorder+Related+to+Childhood+Sexual+Abuse&rft.au=Chard%2C+Kathleen+M&rft.aulast=Chard&rft.aufirst=Kathleen&rft.date=2005-10-01&rft.volume=73&rft.issue=5&rft.spage=965&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Childhood sexual abuse; Cognitive therapy; Treatment; Women ER - TY - JOUR T1 - HIV, hepatitis C and HIV/hepatitis C virus co-infection in vulnerable populations AN - 21044598; 6561547 AB - Objective: To describe basic patient demographic and clinical characteristics of HIV-infected and HIV/hepatitis C virus (HCV)-co-infected patients receiving care in the Department of Veterans Affairs (VA) with a focus on some patient factors that place such patients at an increased risk of poor health outcomes. Design: An observational retrospective cohort study. Methods: The study cohort consisted of veterans in the VA Immunology Case Registry who received care in the VA in 2002. Results: Of 18 349 HIV-infected patients, 6782 (37.0%) were HCV seropositive. Compared with HIV-alone-infected patients, HIV/HCV-co-infected patients were older, more likely to be men, more likely to be black or Hispanic, and more likely to report intravenous drug use as a risk factor for HIV acquisition. HIV/HCV-co-infected patients were more likely to have diagnoses of mental health illness, depression, alcohol abuse, substance abuse and hard drug abuse compared with HIV-alone-infected patients. Co-infected patients were less likely to have a history of an AIDS opportunistic infection ever and were less likely to have received HIV antiretroviral drugs in 2002. Conclusion: The VA's HIV and HIV/HCV-co-infected patient populations have very high rates of additional comorbid conditions that complicate both the pharmacological therapy and clinical course of both HIV and HCV infections. Given the overlap in viral illness and comorbidities, optimal models of integrated care need to be developed for populations with HIV, HCV, and HIV/HCV co-infection and who need substance abuse treatment or mental healthcare. JF - AIDS AU - Backus, LI AU - Boothroyd, D AU - Deyton, L R AD - PHSHCG 13B, US Department of Veterans Affairs, 810 Vermont Avenue NW, Washington, DC 20420, USA, dr.bopper.deyton@hq.med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - S13 EP - S19 VL - 19 SN - 0269-9370, 0269-9370 KW - HIV KW - Immunology Abstracts; Risk Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Risk assessment KW - drug abuse KW - Alcohol KW - Historical account KW - Acquired immune deficiency syndrome KW - Intravenous administration KW - Depression KW - Drug abuse KW - Morbidity KW - Models KW - Opportunist infection KW - Hepatitis KW - substance abuse KW - Demography KW - infectious diseases KW - Mental disorders KW - Hepatitis C virus KW - Health care KW - Antiviral agents KW - Human immunodeficiency virus KW - Risk factors KW - Hepatitis C KW - H 11000:Diseases/Injuries/Trauma KW - V 22005:AIDS: Epidemiological aspects KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21044598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=HIV%2C+hepatitis+C+and+HIV%2Fhepatitis+C+virus+co-infection+in+vulnerable+populations&rft.au=Backus%2C+LI%3BBoothroyd%2C+D%3BDeyton%2C+L+R&rft.aulast=Backus&rft.aufirst=LI&rft.date=2005-10-01&rft.volume=19&rft.issue=&rft.spage=S13&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Demography; Risk assessment; Mental disorders; Intravenous administration; Acquired immune deficiency syndrome; Depression; Antiviral agents; Risk factors; Hepatitis C; Drug abuse; Opportunist infection; Models; substance abuse; Hepatitis; Historical account; Alcohol; drug abuse; infectious diseases; Health care; Morbidity; Hepatitis C virus; Human immunodeficiency virus ER - TY - JOUR T1 - The threat of antibiotic resistance in Gram-negative pathogenic bacteria: beta -lactams in peril! AN - 20868238; 8336556 AB - beta -Lactam antibiotics are the cornerstone of our antibiotic armamentarium. By inhibiting bacterial cell wall synthesis, they are highly effective against Gram-positive and Gram-negative bacteria. Unfortunately, bacteria have evolved sophisticated resistance mechanisms to combat the lethal effects of beta -lactam antibiotics. Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae are all able to evade killing by penicillins, cephalosporins and carbapenems. This multi-drug resistant phenotype that challenges healthcare workers worldwide is caused by an array of resistance determinants. These include altered expression of outer membrane proteins and efflux pumps, along with an increasing arsenal of beta -lactamases. Future strategies in beta -lactam design must take into account the complex nature of resistance in Gram-negative pathogens. JF - Current Opinion in Microbiology AU - Thomson, Jodi M AU - Bonomo, Robert A AD - Department of Pharmacology, Case Western Reserve University School of Medicine and Department of Medicine, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA, robert.bonomo@med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 518 EP - 524 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 8 IS - 5 SN - 1369-5274, 1369-5274 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cephalosporins KW - beta -Lactamase KW - outer membrane proteins KW - Carbapenems KW - Antibiotics KW - Pathogens KW - Penicillin KW - Medical personnel KW - Acinetobacter baumannii KW - Reviews KW - Gram-negative bacteria KW - beta -Lactam antibiotics KW - Pseudomonas aeruginosa KW - Antibiotic resistance KW - Klebsiella pneumoniae KW - Cell walls KW - A 01340:Antibiotics & Antimicrobials KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20868238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Microbiology&rft.atitle=The+threat+of+antibiotic+resistance+in+Gram-negative+pathogenic+bacteria%3A+beta+-lactams+in+peril%21&rft.au=Thomson%2C+Jodi+M%3BBonomo%2C+Robert+A&rft.aulast=Thomson&rft.aufirst=Jodi&rft.date=2005-10-01&rft.volume=8&rft.issue=5&rft.spage=518&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Microbiology&rft.issn=13695274&rft_id=info:doi/10.1016%2Fj.mib.2005.08.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cephalosporins; outer membrane proteins; beta -Lactamase; Carbapenems; Antibiotics; Pathogens; Medical personnel; Penicillin; Gram-negative bacteria; Reviews; beta -Lactam antibiotics; Antibiotic resistance; Cell walls; Acinetobacter baumannii; Pseudomonas aeruginosa; Klebsiella pneumoniae DO - http://dx.doi.org/10.1016/j.mib.2005.08.014 ER - TY - JOUR T1 - ANTIINFECTANTS: Population pharmacokinetics of pyrazinamide in elephants AN - 20717363; 6555046 AB - This study was undertaken to characterize the population pharmacokinetics (PK), therapeutic dose, and preferred route of administration for pyrazinamide (PZA) in elephants. Twenty-three African (Loxodonta africana) and Asian (Elephas maximus) elephants infected with or in contact with others culture positive for Mycobacterium tuberculosis were dosed under treatment conditions. PZA was dosed daily at 20-30 mg/kg via oral (fasting or nonfasting state) or rectal (enema or suppository) administration. Blood samples were collected 0-24 h postdose. Population PK was estimated using nonlinear mixed effect modeling. Drug absorption was rapid with T sub(max) at or before 2 h regardless of the method of drug administration. C sub(max) at a mean dose of 25.6 ( plus or minus 4.6) mg/kg was 19.6 ( plus or minus 9.5 mu g/mL) for PZA given orally under fasting conditions. Under nonfasting conditions at a mean dose of 26.1 plus or minus 4.2 mg/kg, C sub(max) was 25% (4.87 plus or minus 4.89 mu g/mL) and area under concentration curve (AUC) was 30% of the values observed under fasting conditions. Mean rectal dose of 32.6 plus or minus 15.2 mg/kg yielded C sub(max) of 12.3 plus or minus 6.3 mu g/mL, but comparable AUC to PZA administered orally while fasting. Both oral and rectal administration of PZA appeared to be acceptable and oral dosing is preferred because of the higher C sub(max) and lower inter-subject variability. A starting dose of 30 mg/kg is recommended with drug monitoring between 1 and 2 h postdose. Higher doses may be required if the achieved C sub(max) values are below the recommended 20-50 mu g/mL range. JF - Journal of Veterinary Pharmacology and Therapeutics AU - Zhu, M AU - Maslow, J N AU - Mikota, S K AU - Isaza, R AU - Dunker, F AU - Riddle, H AU - Peloquin, CA AD - Section of Infectious Diseases, VA Medical Center and the Division of Infectious Diseases, University of Pennsylvania, Philadelphia, PA, USA, joel.maslow@med.va.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 403 EP - 409 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 28 IS - 5 SN - 0140-7783, 0140-7783 KW - Microbiology Abstracts B: Bacteriology KW - Elephas maximus KW - Rectum KW - Loxodonta africana KW - Elephantidae KW - pyrazinamide KW - Fasting KW - Drugs KW - Pharmacokinetics KW - Mycobacterium tuberculosis KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20717363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.atitle=ANTIINFECTANTS%3A+Population+pharmacokinetics+of+pyrazinamide+in+elephants&rft.au=Zhu%2C+M%3BMaslow%2C+J+N%3BMikota%2C+S+K%3BIsaza%2C+R%3BDunker%2C+F%3BRiddle%2C+H%3BPeloquin%2C+CA&rft.aulast=Zhu&rft.aufirst=M&rft.date=2005-10-01&rft.volume=28&rft.issue=5&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.issn=01407783&rft_id=info:doi/10.1111%2Fj.1365-2885.2005.00670.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - SuppNotes - Figures, 5; tables, 1. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Rectum; pyrazinamide; Fasting; Drugs; Pharmacokinetics; Elephas maximus; Loxodonta africana; Elephantidae; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1111/j.1365-2885.2005.00670.x ER - TY - JOUR T1 - The Art of Prescribing. Mitigating Cutaneous Side Effects of Lamotrigine AN - 20236214; 6564530 JF - Perspectives in Psychiatric Care AU - Antai-Otong, Deborah Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 193 EP - 196 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 41 IS - 4 SN - 0031-5990, 0031-5990 KW - Toxicology Abstracts KW - lamotrigine KW - Side effects KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20236214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+in+Psychiatric+Care&rft.atitle=The+Art+of+Prescribing.+Mitigating+Cutaneous+Side+Effects+of+Lamotrigine&rft.au=Antai-Otong%2C+Deborah&rft.aulast=Antai-Otong&rft.aufirst=Deborah&rft.date=2005-10-01&rft.volume=41&rft.issue=4&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Perspectives+in+Psychiatric+Care&rft.issn=00315990&rft_id=info:doi/10.1111%2Fj.1744-6163.2005.00041.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - SuppNotes - Tables, 1; references, 14. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - lamotrigine; Side effects DO - http://dx.doi.org/10.1111/j.1744-6163.2005.00041.x ER - TY - JOUR T1 - Molecular Basis of Reduced Potency of Underacylated Endotoxins AN - 19933288; 6528252 AB - Potent TLR4-dependent cell activation by Gram-negative bacterial endotoxins depends on sequential endotoxin-protein and protein-protein interactions with LPS-binding protein, CD14, myeloid differentiation protein 2 (MD-2), and TLR4. Previous studies have suggested that reduced agonist potency of underacylated endotoxins (i.e., tetra- or penta- vs hexa-acylated) is determined by post-CD14 interactions. To better define the molecular basis of the differences in agonist potency of endotoxins differing in fatty acid acylation, we compared endotoxins (lipooligosaccharides (LOS)) from hexa-acylated wild-type (wt), penta-acylated mutant msbB meningococcal strains as well as tetra-acylated LOS generated by treatment of wt LOS with the deacylating enzyme, acyloxyacylhydrolase. To facilitate assay of endotoxin:protein and endotoxin:cell interactions, the endotoxins were purified after metabolic labeling with [ super(3)H]- or [ super(14)C]acetate. All LOS species tested formed monomeric complexes with MD-2 in an LPS-binding protein- and CD14-dependent manner with similar efficiency. However, msbB LOS:MD-2 and acyloxyacylhydrolase-treated LOS:MD-2 were at least 10-fold less potent in inducing TLR4-dependent cell activation than wt LOS:MD-2 and partially antagonized the action of wt LOS:MD-2. These findings suggest that underacylated endotoxins produce decreased TLR4-dependent cell activation by altering the interaction of the endotoxin:MD-2 complex with TLR4 in a way that reduces receptor activation. Differences in potency among these endotoxin species is determined not by different aggregate properties, but by different properties of monomeric endotoxin:MD-2 complexes. JF - Journal of Immunology AU - Teghanemt, Athmane AU - Zhang, DeSheng AU - Levis, Erika N AU - Weiss, Jerrold P AU - Gioannini, Theresa L AD - Inflammation Program, Departments of Internal Medicine, Department of Biochemistry, Coralville, IA 52241. Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, and Veterans Administration Medical Center, Iowa City, IA 52241 Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 4669 EP - 4676 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 175 IS - 7 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Endotoxins KW - Receptor mechanisms KW - Enzymes KW - Neisseria meningitidis KW - Acylation KW - CD14 antigen KW - Lipooligosaccharides KW - Cell activation KW - Differentiation KW - LPS-binding protein KW - Fatty acids KW - TLR4 protein KW - Protein interaction KW - Toll-like receptors KW - A 01490:Miscellaneous KW - F 06106:Bacteria KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19933288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Molecular+Basis+of+Reduced+Potency+of+Underacylated+Endotoxins&rft.au=Teghanemt%2C+Athmane%3BZhang%2C+DeSheng%3BLevis%2C+Erika+N%3BWeiss%2C+Jerrold+P%3BGioannini%2C+Theresa+L&rft.aulast=Teghanemt&rft.aufirst=Athmane&rft.date=2005-10-01&rft.volume=175&rft.issue=7&rft.spage=4669&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Endotoxins; Receptor mechanisms; Enzymes; Acylation; CD14 antigen; Cell activation; Lipooligosaccharides; Differentiation; Fatty acids; LPS-binding protein; TLR4 protein; Toll-like receptors; Protein interaction; Neisseria meningitidis ER - TY - JOUR T1 - In Vitro Activities of Doripenem and Comparator Agents against 364 Anaerobic Clinical Isolates AN - 17661122; 6505836 AB - The in vitro activities of doripenem against 364 anaerobic isolates were measured and compared to those of ertapenem, imipenem, meropenem, ceftriaxone, and levofloxacin. All of the carbapenems were active against nearly all Bacteroides fragilis group isolates. Doripenem was either comparable to or slightly less active than imipenem and meropenem against most isolates but more active than the other penems against Clostridium difficile. Doripenem appears to have excellent activity against a broad range of anaerobes. JF - Antimicrobial Agents & Chemotherapy AU - Wexler, Hannah M AU - Engel, Adrian E AU - Glass, Daniel AU - Li, Calida AD - Medical and Research Services, Greater Los Angeles Veterans Administration Health Care Services, Los Angeles, California. Department of Medicine, UCLA School of Medicine, Los Angeles, California Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 4413 EP - 4417 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 49 IS - 10 SN - 0066-4804, 0066-4804 KW - Doripenem KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - A 01066:Antibacterial & bactericidal KW - J 02812:Antibacterial Agents: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17661122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+Vitro+Activities+of+Doripenem+and+Comparator+Agents+against+364+Anaerobic+Clinical+Isolates&rft.au=Wexler%2C+Hannah+M%3BEngel%2C+Adrian+E%3BGlass%2C+Daniel%3BLi%2C+Calida&rft.aulast=Wexler&rft.aufirst=Hannah&rft.date=2005-10-01&rft.volume=49&rft.issue=10&rft.spage=4413&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-12-01 N1 - Last updated - 2011-12-13 ER - TY - CPAPER T1 - In Vitro Activity of DX-619 and Four Comparator Agents Against 376 Anaerobic Bacterial Isolates T2 - 45th Interscience Conference on Antimicrobial Agents and Chemotherapy AN - 39981008; 3986852 JF - 45th Interscience Conference on Antimicrobial Agents and Chemotherapy AU - Finegold Y1 - 2005/09/21/ PY - 2005 DA - 2005 Sep 21 KW - Antimicrobial agents KW - Chemotherapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39981008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy&rft.atitle=In+Vitro+Activity+of+DX-619+and+Four+Comparator+Agents+Against+376+Anaerobic+Bacterial+Isolates&rft.au=Finegold&rft.aulast=Finegold&rft.aufirst=&rft.date=2005-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Aspirin use in chronic heart failure: what should we recommend to the practitioner? AN - 68592346; 16168276 AB - There has been ongoing controversy as to whether aspirin should be used in patients with chronic heart failure (CHF). The argument for aspirin is that many patients have underlying coronary disease, and aspirin prevents reinfarction and other vascular events. Arguments against the routine use of aspirin are that many CHF patients do not have underlying coronary disease, and that the benefit of aspirin lessens after the first 6 to 12 months after infarction. Also, several analyses suggest that aspirin may actually worsen outcomes in CHF patients, possibly because it inhibits prostaglandins, with resulting adverse hemodynamic and renal effects. Two recent prospective randomized studies have found that aspirin is associated with more frequent hospitalizations for worsening heart failure, although it did not have an adverse effect on vascular events. These results suggest that aspirin should not be routinely used in CHF patients and be avoided in those with refractory CHF, but that it may be beneficial in patients with recent infarction or multiple vascular risk factors. JF - Journal of the American College of Cardiology AU - Massie, Barry M AD - Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California, USA. barry.massie@med.va.gov Y1 - 2005/09/20/ PY - 2005 DA - 2005 Sep 20 SP - 963 EP - 966 VL - 46 IS - 6 KW - Platelet Aggregation Inhibitors KW - 0 KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Practice Guidelines as Topic KW - Chronic Disease KW - Platelet Aggregation Inhibitors -- adverse effects KW - Platelet Aggregation Inhibitors -- therapeutic use KW - Heart Failure -- drug therapy KW - Aspirin -- adverse effects KW - Aspirin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68592346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Aspirin+use+in+chronic+heart+failure%3A+what+should+we+recommend+to+the+practitioner%3F&rft.au=Massie%2C+Barry+M&rft.aulast=Massie&rft.aufirst=Barry&rft.date=2005-09-20&rft.volume=46&rft.issue=6&rft.spage=963&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=1558-3597&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-22 N1 - Date created - 2005-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - MRI Confirms Mild Cognitive Impairment Prodromal for Different Dementias T2 - 9th Congress of the European Federation of Neurological Societies (EFNS 2005) AN - 39704997; 4019257 JF - 9th Congress of the European Federation of Neurological Societies (EFNS 2005) AU - Meyer, J S AU - Huang, J AU - Chowdhury, M H Y1 - 2005/09/17/ PY - 2005 DA - 2005 Sep 17 KW - Magnetic resonance imaging KW - Cognitive ability KW - Dementia disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39704997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+Congress+of+the+European+Federation+of+Neurological+Societies+%28EFNS+2005%29&rft.atitle=MRI+Confirms+Mild+Cognitive+Impairment+Prodromal+for+Different+Dementias&rft.au=Meyer%2C+J+S%3BHuang%2C+J%3BChowdhury%2C+M+H&rft.aulast=Meyer&rft.aufirst=J&rft.date=2005-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+Congress+of+the+European+Federation+of+Neurological+Societies+%28EFNS+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/efns2005/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Application of a disease-specific mapping function to estimate utility gains with effective treatment of schizophrenia. AN - 68695175; 16153308 AB - Most tools for estimating utilities use clinical trial data from general health status models, such as the 36-Item Short-Form Health Survey (SF-36). A disease-specific model may be more appropriate. The objective of this study was to apply a disease-specific utility mapping function for schizophrenia to data from a large, 1-year, open-label study of long-acting risperidone and to compare its performance with an SF-36-based utility mapping function. Patients with schizophrenia or schizoaffective disorder by DSM-IV criteria received 25, 50, or 75 mg long-acting risperidone every 2 weeks for 12 months. The Positive and Negative Syndrome Scale (PANSS) and SF-36 were used to assess efficacy and health-related quality of life. Movement disorder severity was measured using the Extrapyramidal Symptom Rating Scale (ESRS); data concerning other common adverse effects (orthostatic hypotension, weight gain) were collected. Transforms were applied to estimate utilities. A total of 474 patients completed the study. Long-acting risperidone treatment was associated with a utility gain of 0.051 using the disease-specific function. The estimated gain using an SF-36-based mapping function was smaller: 0.0285. Estimates of gains were only weakly correlated (r = 0.2). Because of differences in scaling and variance, the requisite sample size for a randomized trial to confirm observed effects is much smaller for the disease-specific mapping function (156 versus 672 total subjects). Application of a disease-specific mapping function was feasible. Differences in scaling and precision suggest the clinically based mapping function has greater power than the SF-36-based measure to detect differences in utility. JF - Health and quality of life outcomes AU - Lenert, Leslie A AU - Rupnow, Marcia F T AU - Elnitsky, Christine AD - Veterans Administration San Diego Health Care System, San Diego, California, USA. llenert@ucsd.edu Y1 - 2005/09/11/ PY - 2005 DA - 2005 Sep 11 SP - 57 VL - 3 KW - Antipsychotic Agents KW - 0 KW - Delayed-Action Preparations KW - Risperidone KW - L6UH7ZF8HC KW - Index Medicus KW - Administration, Oral KW - Psychiatric Status Rating Scales KW - Humans KW - Adult KW - Quality of Life KW - Middle Aged KW - Male KW - Female KW - Antipsychotic Agents -- therapeutic use KW - Risperidone -- administration & dosage KW - Schizophrenia -- diagnosis KW - Schizophrenia -- physiopathology KW - Antipsychotic Agents -- administration & dosage KW - Sickness Impact Profile KW - Outcome Assessment (Health Care) -- methods KW - Schizophrenia -- drug therapy KW - Risperidone -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Psychotic Disorders -- diagnosis KW - Risperidone -- therapeutic use KW - Psychotic Disorders -- physiopathology KW - Psychotic Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68695175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+and+quality+of+life+outcomes&rft.atitle=Application+of+a+disease-specific+mapping+function+to+estimate+utility+gains+with+effective+treatment+of+schizophrenia.&rft.au=Lenert%2C+Leslie+A%3BRupnow%2C+Marcia+F+T%3BElnitsky%2C+Christine&rft.aulast=Lenert&rft.aufirst=Leslie&rft.date=2005-09-11&rft.volume=3&rft.issue=&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Health+and+quality+of+life+outcomes&rft.issn=1477-7525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-31 N1 - Date created - 2005-10-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Med Decis Making. 2003 Jan-Feb;23(1):67-75 [12583456] Med Care. 2003 Feb;41(2):208-17 [12555049] JAMA. 2003 Nov 26;290(20):2693-702 [14645311] J Clin Psychiatry. 2003 Oct;64(10):1250-7 [14658976] Med Care. 2004 Feb;42(2):183-96 [14734956] Med Care. 2004 Sep;42(9):851-9 [15319610] Med Care. 2004 Sep;42(9):927-37 [15319619] Schizophr Res. 2004 Nov 1;71(1):83-95 [15374576] Schizophr Res. 2004 Nov 1;71(1):155-65 [15374583] Br J Psychiatry Suppl. 1989 Nov;(7):59-67 [2619982] Med Care. 1992 Jun;30(6):473-83 [1593914] Med Care. 1996 Mar;34(3):220-33 [8628042] Med Care. 1996 Jul;34(7):702-22 [8676608] Med Decis Making. 1997 Jan-Mar;17(1):1-9 [8994146] Pharmacoeconomics. 1997 Feb;11(2):159-68 [10172935] N Engl J Med. 1997 Sep 18;337(12):809-15 [9295240] BMJ. 1998 Mar 7;316(7133):736-41 [9529408] Health Serv Res. 1998 Dec;33(5 Pt 1):1237-61 [9865219] Int J Qual Health Care. 1998 Dec;10(6):509-20 [9928590] J Affect Disord. 2004 Dec;83(2-3):263-75 [15555724] Med Care. 2000 Jul;38(7):763-70 [10901359] Med Decis Making. 2001 Mar-Apr;21(2):105-12 [11310943] Ann Med. 2001 Jul;33(5):375-84 [11491197] Med Care. 2001 Nov;39(11):1246-59 [11606878] J Health Econ. 2002 Mar;21(2):271-92 [11939242] Proc AMIA Symp. 2002;:440-4 [12463862] Qual Life Res. 2003 Jun;12(4):363-71 [12797709] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of work hour reduction on residents' lives: a systematic review. AN - 68557789; 16145030 AB - The Accreditation Council for Graduate Medical Education implemented mandatory work hour limitations in July 2003, partly out of concern for residents' well-being in the setting of sleep deprivation. These limitations are likely to also have an impact on other aspects of the lives of residents. To summarize the literature regarding the effect of interventions to reduce resident work hours on residents' education and quality of life. We searched the English-language literature about resident work hours from 1966 through April 2005 using MEDLINE, EMBASE, and Current Contents, supplemented with hand-search of additional journals, reference list review, and review of abstracts from national meetings. Studies were included that assessed a system change designed to counteract the effects of resident work hours, fatigue, or sleep deprivation; included an outcome directly related to residents; and were conducted in the United States. For each included study, 2 investigators independently abstracted data related to study quality, subjects, interventions, and findings using a standard data abstraction form. Fifty-four articles met inclusion criteria. The interventions used to decrease resident work hours varied but included night and day float teams, extra cross-coverage, and physician extenders. Outcomes included measures of resident education (operative experience, test scores, satisfaction) and quality of residents' lives (amount of sleep, well-being). Interventions to reduce resident work hours resulted in mixed effects on both operative experience and on perceived educational quality but generally improved residents' quality of life. Many studies had major limitations in their design or conduct. Past interventions suggest that residents' quality of life may improve with work hour limitations, but interpretation of the outcomes of these studies is hampered by suboptimal study design and the use of nonvalidated instruments. The long-term impact of reducing resident work hours on education remains unknown. Current and future interventions should be evaluated with more rigorous methods and should investigate links between residents' quality of life and quality of patient care. JF - JAMA AU - Fletcher, Kathlyn E AU - Underwood, Willie AU - Davis, Steven Q AU - Mangrulkar, Rajesh S AU - McMahon, Laurence F AU - Saint, Sanjay AD - Department of Internal Medicine, Clement J. Zablocki VA Medical Center/Medical College of Wisconsin, Milwaukee 53295, USA. kathlyn.fletcher@med.va.gov Y1 - 2005/09/07/ PY - 2005 DA - 2005 Sep 07 SP - 1088 EP - 1100 VL - 294 IS - 9 KW - Abridged Index Medicus KW - Index Medicus KW - Education, Medical KW - Sleep Disorders, Circadian Rhythm KW - Fatigue KW - Humans KW - Specialization KW - Work Schedule Tolerance KW - Workload KW - Internship and Residency KW - Quality of Life UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68557789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Effects+of+work+hour+reduction+on+residents%27+lives%3A+a+systematic+review.&rft.au=Fletcher%2C+Kathlyn+E%3BUnderwood%2C+Willie%3BDavis%2C+Steven+Q%3BMangrulkar%2C+Rajesh+S%3BMcMahon%2C+Laurence+F%3BSaint%2C+Sanjay&rft.aulast=Fletcher&rft.aufirst=Kathlyn&rft.date=2005-09-07&rft.volume=294&rft.issue=9&rft.spage=1088&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=1538-3598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-12 N1 - Date created - 2005-09-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: JAMA. 2005 Sep 7;294(9):1104-6 [16145032] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interstitial lung disease following erlotinib (Tarceva) in a patient who previously tolerated gefitinib (Iressa). AN - 69054755; 16390601 AB - To report a case of who a patient developed clinical and radiographical evidence of interstitial lung disease (ILD) on erlotinib after having tolerated gefitinib therapy. A 58-year-old man with stage IV non-small-cell lung cancer (NSCLC) failed first and second line chemotherapy. He then received gefitinib, a small molecule epidermal growth factor receptor (EGFR) inhibitor, a therapy which was well tolerated, but did cause a grade 1 rash. On gefitinib, the patient's disease remained stable for seven months. Subsequent disease progression was treated with the newer EGFR inhibitor, erlotinib. After 5 days of erlotinib therapy, the patient presented with a sore throat and dyspnea, followed by a grade 2 rash and significant hemoptysis. Erlotinib was discontinued for three days, during which time his symptoms abated. Erlotinib was restarted and the patient again developed sore throat, dyspnea and severe hemotpysis, with progression of the rash to grade 3. Erlotinib therapy was discontinued and the patient recevied prednisone and supplemental oxygen. A CT scan of the chest demonstrated new areas of patchy ground glass opacity bilaterally and increased interstitial markings consistent with ILD. The case demonstrates that clinical ILD can occur following erlotinib therapy, even in patients who previously tolerated gefitinib. ILD has not been reported to occur more frequently with erlotinib than with gefitinib. However, the dose of erlotinib employed clinically is the maximum tolerated dose identified in phase 1 trials, and is associated with an increased incidence of grade 3-4 rash and diarrhea, as compared to gefitinib. Thus, the observation of clinical ILD following erlotinib, but not gefitinib, may be the consequence of increased potency of erlotinib 150 mg/day compared to gefitinib 250 mg/day. Clinical ILD can occur following erlotinib even in patients who previously tolerated gefitinib. IT is important to carefully monitor pulmonary symptoms in all patients who are receiving erlotinib, as early diagnosis and timely intervention are critical in managing drug-induced ILD. JF - Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners AU - Tammaro, Kelly A AU - Baldwin, Patricia D AU - Lundberg, Ante S AD - Boston VA Health Care System, MA 02130, USA. Tammaro@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 127 EP - 130 VL - 11 IS - 3 SN - 1078-1552, 1078-1552 KW - Protein Kinase Inhibitors KW - 0 KW - Quinazolines KW - Erlotinib Hydrochloride KW - DA87705X9K KW - gefitinib KW - S65743JHBS KW - Index Medicus KW - Humans KW - Tomography, X-Ray Computed KW - Middle Aged KW - Male KW - Protein Kinase Inhibitors -- adverse effects KW - Lung Neoplasms -- drug therapy KW - Lung Diseases, Interstitial -- diagnostic imaging KW - Quinazolines -- therapeutic use KW - Quinazolines -- adverse effects KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Lung Diseases, Interstitial -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69054755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Tinea+corporis+gladiatorum&rft.au=Adams%2C+B+B&rft.aulast=Adams&rft.aufirst=B&rft.date=2002-01-01&rft.volume=47&rft.issue=&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=01909622&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-26 N1 - Date created - 2006-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Word recognition in multitalker babble measured with two psychophysical methods. AN - 68802208; 16295249 AB - The purpose of this experiment was to determine the relationship between psychometric functions for words presented in multitalker babble using a descending presentation level protocol and a random presentation level protocol. Forty veterans (mean = 63.5 years) with mild-to-moderate sensorineural hearing losses were enrolled. Seventy of the Northwestern University Auditory Test No. 6 words spoken by the VA female speaker were presented at seven signal-to-babble ratios from 24 to 0 dB (10 words/step). Although the random procedure required 69 sec longer to administer than the descending protocol, there was no significant difference between the results obtained with the two psychophysical methods. There was almost no relation between the perceived ability of the listeners to understand speech in background noise and their measured ability to understand speech in multitalker babble. Likewise, there was a tenuous relation between pure-tone thresholds and performance on the words in babble and between recognition performance in quiet and performance on the words in babble. JF - Journal of the American Academy of Audiology AU - Wilson, Richard H AU - Burks, Christopher A AU - Weakley, Deborah G AD - James H. Quillen VA Medical Center, Mountain Home, TN 37684, USA. RICHARD.WILSON2@MED.VA.GOV Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 622 EP - 630 VL - 16 IS - 8 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - Audiometry, Pure-Tone KW - Humans KW - Noise KW - Middle Aged KW - Psychometrics KW - Male KW - Speech Discrimination Tests -- methods KW - Hearing Loss, Sensorineural -- physiopathology KW - Speech Perception -- physiology KW - Perceptual Masking -- physiology KW - Hearing Loss, Sensorineural -- psychology KW - Self-Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68802208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Word+recognition+in+multitalker+babble+measured+with+two+psychophysical+methods.&rft.au=Wilson%2C+Richard+H%3BBurks%2C+Christopher+A%3BWeakley%2C+Deborah+G&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2005-09-01&rft.volume=16&rft.issue=8&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-17 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recent suicide attempt and the effectiveness of inpatient and outpatient substance use disorder treatment. AN - 68649724; 16205366 AB - The present study investigated whether or not the effect of treatment setting (inpatient or outpatient) on 6-mo follow-up substance use varied for suicidal and non-suicidal patients. In particular, the study tested the hypothesis that treatment setting would have no differing effect for non-suicidal participants, but for suicidal participants, inpatient setting would be more closely associated with positive outcomes than the outpatient setting. A national sample of patients presenting for treatment of substance use disorders in the Veterans Administration health care system was selected to participate in the study. A total of 1,289 participants provided complete data on psychiatric and substance-related problems at baseline and 6-mo follow-up. At baseline, 4% (n=53) of the sample reported having made a suicide attempt within the past 30 days. Those who reported a suicide attempt were no more likely to have been treated in an inpatient setting than in an outpatient setting. A significant interaction between baseline suicide attempt and treatment setting was found, such that non-suicidal patients reported similar patterns of substance use when treated in inpatient or outpatient settings, but suicidal patients were significantly more likely to have better substance-related outcomes at 6-mo follow-up if they were treated in inpatient compared with outpatient settings. Suicidal patients displayed substantial improvement after substance use disorders treatment and seem particularly responsive to treatment in inpatient settings. JF - Alcoholism, clinical and experimental research AU - Ilgen, Mark A AU - Tiet, Quyen AU - Finney, John W AU - Harris, Alex H S AD - Center for Health Care Evaluation, Department of Veterans Affairs, Palo Alto Health Care System and Stanford University School of Medicine, Menlo Park, California 94025, USA. Mark.Ilgen@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 1664 EP - 1671 VL - 29 IS - 9 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Outpatients KW - Humans KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Inpatients KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - Suicide, Attempted -- psychology KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68649724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Recent+suicide+attempt+and+the+effectiveness+of+inpatient+and+outpatient+substance+use+disorder+treatment.&rft.au=Ilgen%2C+Mark+A%3BTiet%2C+Quyen%3BFinney%2C+John+W%3BHarris%2C+Alex+H+S&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2005-09-01&rft.volume=29&rft.issue=9&rft.spage=1664&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-22 N1 - Date created - 2005-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol. AN - 68647847; 16205373 AB - This article represents the proceedings of a symposium at the 2004 RSA Meeting held in Vancouver, Canada. The chairs were Arthur I. Cederbaum and Raj Lakshman. The presentations were (1) ethanol regulates 2,6-sialyltransferase (2,6-ST) gene expression posttranscriptionally by the interaction of a cytosolic binding protein with 2,6-ST mRNA in CYP2E1- and ADH-transfected HepG2 cells, by Raj Lakshman; (2) nature versus nurture: HepG2-E47 cells as a tool to investigate mechanisms of ethanol-mediated potentiation of cell killing, by Jan B. Hoek; (3) ethanol up-regulates profibrogenic connective tissue growth factor gene expression in HepG2 cells via cytochrome P-450 2E1-mediated ethanol oxidation, by Masahiro Konishi; (4) role of calcium and calcium-activated enzymes in CYP2E1-dependent toxicity, by Arthur I Cederbaum; (5) the use of cell lines to characterize the role of CYP2E1 in the metabolism of farnesol, by Dennis Koop; and (6) studies with HepG2 cells that express the two major ethanol-metabolizing enzymes, by Terrence M. Donohue. JF - Alcoholism, clinical and experimental research AU - Lakshman, Raj AU - Cederbaum, Arthur I AU - Hoek, Jan B AU - Konishi, Masahiro AU - Koop, Dennis AU - Donohu, Terrence M AD - Lipid Research Laboratory, VA Medical Center, and the Department of Biochemistry, Molecular Biology, and Medicine, George Washington University, Washington, DC 20422, USA. raj.lakshman@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 1726 EP - 1734 VL - 29 IS - 9 SN - 0145-6008, 0145-6008 KW - CTGF protein, human KW - 0 KW - Immediate-Early Proteins KW - Intercellular Signaling Peptides and Proteins KW - Tumor Necrosis Factor-alpha KW - Connective Tissue Growth Factor KW - 139568-91-5 KW - Ethanol KW - 3K9958V90M KW - Farnesol KW - 4602-84-0 KW - Alcohol Dehydrogenase KW - EC 1.1.1.1 KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Sialyltransferases KW - EC 2.4.99.- KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Humans KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Intercellular Signaling Peptides and Proteins -- genetics KW - Oxidation-Reduction KW - Immediate-Early Proteins -- genetics KW - Sialyltransferases -- genetics KW - Transfection KW - Alcohol Dehydrogenase -- physiology KW - Calcium -- physiology KW - p38 Mitogen-Activated Protein Kinases -- physiology KW - Farnesol -- metabolism KW - Cell Line KW - Liver -- drug effects KW - Ethanol -- toxicity KW - Cytochrome P-450 CYP2E1 -- physiology KW - Ethanol -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68647847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Use+of+CYP2E1-transfected+human+liver+cell+lines+in+elucidating+the+actions+of+ethanol.&rft.au=Lakshman%2C+Raj%3BCederbaum%2C+Arthur+I%3BHoek%2C+Jan+B%3BKonishi%2C+Masahiro%3BKoop%2C+Dennis%3BDonohu%2C+Terrence+M&rft.aulast=Lakshman&rft.aufirst=Raj&rft.date=2005-09-01&rft.volume=29&rft.issue=9&rft.spage=1726&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-22 N1 - Date created - 2005-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antiretroviral therapy in HIV-positive men is associated with increased apolipoprotein CIII in triglyceride-rich lipoproteins. AN - 68580928; 16156880 AB - Dyslipidaemia has become a common problem in HIV disease, especially in patients on current antiretroviral therapy. However, the pathogenic mechanisms involved are not well understood or documented using conventional lipid measurements. Using a cross-sectional design, the prevalence of abnormal standard lipid measurements and novel biomarkers for abnormal lipid metabolism was determined in 271 HIV-positive men from two HIV clinics in Atlanta, GA, USA. A total of 147 men were treated with protease inhibitors (PIs) for >3 months (54%), 84 were treated with nonnucleoside reverse transcriptase inhibitors (NNRTIs) for >3 months (31%) and 40 had not received antiretroviral therapy in the past 3 months (15%). Patients being treated with a PI had higher total cholesterol and triglyceride (TG) levels than patients on no therapy (P<0.05 for each). Patients in the NNRTI group had higher TG, lower high-density lipoprotein (HDL) levels, and higher low-density lipoprotein (LDL) levels than patients on no therapy (P<0.05 for each). Patients treated with either PIs or NNRTIs were more likely to have higher apolipoprotein CIII (apoCIII) levels (P<0.05 for each) than patients on no therapy. Elevated TG was associated with disproportionably elevated apoCIII levels in both treatment groups. In this cross-sectional study of HIV-infected men, either PI or NNRTI therapy elevated levels of TG and apoCIII. Higher concentrations of apoCIII in apoB-containing lipoproteins [very low-density lipoproteins (VLDLs), intermediate density lipoprotein (IDL) and LDLs] have been predictive of an increased incidence of coronary events in clinical trials and more rapid progression of coronary lesions measured by angiography. These findings, on a background of an older population with additional risk factors of smoking and diabetes, portend future atherosclerotic events in these patients. JF - HIV medicine AU - Rimland, D AU - Guest, J L AU - Hernández, I AU - Del Rio, C AU - Le, N A AU - Brown, W V AD - Atlanta VA Medical Center, Atlanta, GA 30033, USA. david.rimland@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 326 EP - 333 VL - 6 IS - 5 SN - 1464-2662, 1464-2662 KW - Anti-HIV Agents KW - 0 KW - Apolipoprotein C-III KW - Apolipoproteins C KW - HIV Protease Inhibitors KW - Reverse Transcriptase Inhibitors KW - Triglycerides KW - Index Medicus KW - Reverse Transcriptase Inhibitors -- adverse effects KW - Cross-Sectional Studies KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - HIV Protease Inhibitors -- therapeutic use KW - Reverse Transcriptase Inhibitors -- therapeutic use KW - HIV Protease Inhibitors -- adverse effects KW - Male KW - Triglycerides -- blood KW - Dyslipidemias -- blood KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- blood KW - HIV Infections -- drug therapy KW - Anti-HIV Agents -- adverse effects KW - Apolipoproteins C -- blood KW - Dyslipidemias -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68580928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=HIV+medicine&rft.atitle=Antiretroviral+therapy+in+HIV-positive+men+is+associated+with+increased+apolipoprotein+CIII+in+triglyceride-rich+lipoproteins.&rft.au=Rimland%2C+D%3BGuest%2C+J+L%3BHern%C3%A1ndez%2C+I%3BDel+Rio%2C+C%3BLe%2C+N+A%3BBrown%2C+W+V&rft.aulast=Rimland&rft.aufirst=D&rft.date=2005-09-01&rft.volume=6&rft.issue=5&rft.spage=326&rft.isbn=&rft.btitle=&rft.title=HIV+medicine&rft.issn=14642662&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-06 N1 - Date created - 2005-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Biomechanical evaluation of kyphoplasty with calcium sulfate cement in a cadaveric osteoporotic vertebral compression fracture model. AN - 68575092; 16153574 AB - Vertebral compression fractures can cause deformity, pain, and disability. Kyphoplasty involves percutaneous insertion of an inflatable balloon tamp into a fractured vertebra followed by injection of polymethylmethacrylate (PMMA) bone cement. PMMA has several disadvantages such as potential thermal necrosis and monomer toxicity. Calcium sulfate cement (CSC) is nontoxic, osteoconductive, and bioabsorbable. To evaluate the biomechanical performance of CSC for kyphoplasty in cadaveric osteoporotic vertebral bodies. Destructive biomechanical tests using fresh cadaveric thoracolumbar vertebral bodies. Thirty-three vertebral bodies (T9 to L4) from osteoporotic cadaveric spines were disarticulated, stripped of soft tissue, and measured for height and volume. Each vertebral body was compressed at 0.5 mm/s using a hinged plating system on a materials testing machine to create an anterior wedge fracture and reduce the anterior height by 25%. Pretreatment strength and stiffness were measured. Two KyphX inflatable balloon tamps were used to reexpand each vertebral body. After randomization, three groups were created: Group A-no cement; Group B-PMMA; Group C-calcium sulfate cement. Groups B and C were filled with the corresponding cement to 25% of the vertebral body volume. All vertebral bodies were then recompressed by 25% of the post-kyphoplasty anterior height to obtain posttreatment strength and stiffness. Treatment with PMMA restored vertebral strength to 127% of the intact level (4168.2 N+/-2288.7) and stiffness to 70% of the intact level (810.0 N/mm+/-380.6). Treatment with CSC restored strength to 108% of the intact level (3429.6 N+/-2440.7) and stiffness to 46% of the intact level (597.7 N/mm+/-317.5). CSC and PMMA were not significantly different for strength restoration (p=.4). Significantly greater strength restoration was obtained with either PMMA or CSC, compared with the control group (p=.003 and .03, respectively). Stiffness restoration tended to be greater with PMMA than for CSC, but this difference was not statistically significant (p=.1). Both cements had significantly greater stiffness when compared with the control group (p=.001 and p=.04, respectively). Use of CSC for kyphoplasty yields similar vertebral body strength and stiffness as compared with PMMA. It may be a useful alternative bone cement for kyphoplasty. Further studies are required to assess the bioabsorption of CSCs after kyphoplasty in vivo. JF - The spine journal : official journal of the North American Spine Society AU - Perry, Andrew AU - Mahar, Andrew AU - Massie, Jennifer AU - Arrieta, Noemi AU - Garfin, Steven AU - Kim, Choll AD - Veterans Administration and University of California, San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, USA. PY - 2005 SP - 489 EP - 493 VL - 5 IS - 5 SN - 1529-9430, 1529-9430 KW - Bone Cements KW - 0 KW - Polymethyl Methacrylate KW - 9011-14-7 KW - Calcium Sulfate KW - WAT0DDB505 KW - Index Medicus KW - Cadaver KW - Aged, 80 and over KW - Humans KW - Biomechanical Phenomena KW - In Vitro Techniques KW - Aged KW - Male KW - Female KW - Thoracic Vertebrae -- injuries KW - Lumbar Vertebrae -- injuries KW - Fractures, Compression -- therapy KW - Spinal Fractures -- physiopathology KW - Thoracic Vertebrae -- physiopathology KW - Lumbar Vertebrae -- physiopathology KW - Calcium Sulfate -- administration & dosage KW - Spinal Fractures -- therapy KW - Osteoporosis -- complications KW - Fractures, Compression -- physiopathology KW - Fractures, Compression -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68575092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+spine+journal+%3A+official+journal+of+the+North+American+Spine+Society&rft.atitle=Biomechanical+evaluation+of+kyphoplasty+with+calcium+sulfate+cement+in+a+cadaveric+osteoporotic+vertebral+compression+fracture+model.&rft.au=Perry%2C+Andrew%3BMahar%2C+Andrew%3BMassie%2C+Jennifer%3BArrieta%2C+Noemi%3BGarfin%2C+Steven%3BKim%2C+Choll&rft.aulast=Perry&rft.aufirst=Andrew&rft.date=2005-09-01&rft.volume=5&rft.issue=5&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=The+spine+journal+%3A+official+journal+of+the+North+American+Spine+Society&rft.issn=15299430&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-24 N1 - Date created - 2005-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pilot evaluation of pulse itraconazole vs. terbinafine for treatment of Candida toenail onychomycosis. AN - 68544421; 16135154 JF - International journal of dermatology AU - Warshaw, Erin M AU - Nelson, David AU - Carver, Susan M AU - Zielke, Gary R AU - Webster, Nancy AU - Lederle, Frank A AU - Fett, Debra D AD - University of Minnesota, Minneapolis, MN, USA. erin.warshaw@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 785 EP - 788 VL - 44 IS - 9 SN - 0011-9059, 0011-9059 KW - Antifungal Agents KW - 0 KW - Naphthalenes KW - Itraconazole KW - 304NUG5GF4 KW - terbinafine KW - G7RIW8S0XP KW - Index Medicus KW - Antifungal Agents -- adverse effects KW - Dose-Response Relationship, Drug KW - Humans KW - Aged KW - Gastrointestinal Diseases -- chemically induced KW - Pilot Projects KW - Pruritus -- chemically induced KW - Candida -- isolation & purification KW - Antifungal Agents -- therapeutic use KW - Candida -- drug effects KW - Antifungal Agents -- pharmacology KW - Aged, 80 and over KW - Patient Dropouts KW - Treatment Outcome KW - Middle Aged KW - Species Specificity KW - Microbial Sensitivity Tests KW - Female KW - Male KW - Naphthalenes -- therapeutic use KW - Naphthalenes -- pharmacology KW - Candidiasis -- microbiology KW - Candidiasis -- drug therapy KW - Itraconazole -- therapeutic use KW - Itraconazole -- pharmacology KW - Naphthalenes -- adverse effects KW - Itraconazole -- adverse effects KW - Foot Dermatoses -- drug therapy KW - Onychomycosis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68544421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+dermatology&rft.atitle=A+pilot+evaluation+of+pulse+itraconazole+vs.+terbinafine+for+treatment+of+Candida+toenail+onychomycosis.&rft.au=Warshaw%2C+Erin+M%3BNelson%2C+David%3BCarver%2C+Susan+M%3BZielke%2C+Gary+R%3BWebster%2C+Nancy%3BLederle%2C+Frank+A%3BFett%2C+Debra+D&rft.aulast=Warshaw&rft.aufirst=Erin&rft.date=2005-09-01&rft.volume=44&rft.issue=9&rft.spage=785&rft.isbn=&rft.btitle=&rft.title=International+journal+of+dermatology&rft.issn=00119059&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-21 N1 - Date created - 2005-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. AN - 68511512; 15878913 AB - For the past 60 years, dietary intake of essential fatty acids has increased. Moreover, the omega-6 fatty acids have recently been found to play an important role in regulation of gene expression. Proliferation of human prostate cells was significantly increased 48 h after arachidonic acid (AA) addition. We have analyzed initial uptake using nile red fluorescence and we found that the albumin conjugated AA is endocytosed into the cells followed by the induction of RNA within minutes, protein and PGE2 synthesis within hours. Here we describe that AA induces expression of cytosolic phospholipase A2 (cPLA2) in a dose-dependent manner and that this upregulation is dependent upon downstream synthesis of PGE2. The upregulation of cox-2 and cPLA2 was inhibited by flurbiprofen, a cyclooxygenase (COX) inhibitor, making this a second feed-forward enzyme in the eicosanoid pathway. Cox-2 specific inhibitors are known to inhibit colon and prostate cancer growth in humans; however, recent findings show that some of these have cardiovascular complications. Since cPLA2 is upstream in the eicosanoid pathway, it may be a good alternative for a pharmaceutical target for the treatment of cancer. JF - Carcinogenesis AU - Hughes-Fulford, Millie AU - Tjandrawinata, Raymond R AU - Li, Chai-Fei AU - Sayyah, Sina AD - Laboratory of Cell Growth, Mail Code 151F, Department of Medicine, Northern California Institute for Research and Education and Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA. millie.hughes-fulford@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 1520 EP - 1526 VL - 26 IS - 9 SN - 0143-3334, 0143-3334 KW - Membrane Proteins KW - 0 KW - Proto-Oncogene Proteins c-fos KW - RNA, Messenger KW - Arachidonic Acid KW - 27YG812J1I KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Phospholipases A KW - EC 3.1.1.32 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Index Medicus KW - Space life sciences KW - NASA Discipline Cell Biology KW - Non-NASA Center KW - Humans KW - Cell Line, Tumor KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Gene Expression Regulation, Neoplastic KW - Promoter Regions, Genetic KW - Gene Expression Regulation, Enzymologic KW - Enzyme Induction -- drug effects KW - Proto-Oncogene Proteins c-fos -- genetics KW - Prostatic Neoplasms -- enzymology KW - Prostaglandin-Endoperoxide Synthases -- genetics KW - Cytoplasm -- enzymology KW - Male KW - Cell Division KW - Phospholipases A -- genetics KW - Arachidonic Acid -- pharmacology KW - Arachidonic Acid -- pharmacokinetics KW - Phospholipases A -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68511512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Arachidonic+acid%2C+an+omega-6+fatty+acid%2C+induces+cytoplasmic+phospholipase+A2+in+prostate+carcinoma+cells.&rft.au=Hughes-Fulford%2C+Millie%3BTjandrawinata%2C+Raymond+R%3BLi%2C+Chai-Fei%3BSayyah%2C+Sina&rft.aulast=Hughes-Fulford&rft.aufirst=Millie&rft.date=2005-09-01&rft.volume=26&rft.issue=9&rft.spage=1520&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-07 N1 - Date created - 2005-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Capecitabine-warfarin interaction. AN - 68479632; 16014372 AB - To report a case of concomitant warfarin therapy with consecutive cycles of capecitabine therapy, providing time of onset, magnitude, and assessment of the interaction. A 59-year-old man receiving chronic warfarin therapy for a mechanical mitral valve replacement was diagnosed with stage IV metastatic colon cancer. He was started on capecitabine/irinotecan after his cancer progressed with fluorouracil/leucovorin and the FOLFOX 6 regimen (oxaliplatin, leucovorin, and continuous fluorouracil infusion). He received 3 consecutive cycles of capecitabine/irinotecan with concomitant oral anticoagulation and, with each cycle, the warfarin dose was reduced. Over the course of these 3 cycles, the total weekly dose of warfarin was reduced by >85%. The capecitabine-warfarin interaction is clinically significant, requiring a black box warning in the package insert. The mechanism of action for the interaction is not clear, but may be related to down-regulation of CYP2C9 by capecitabine or its metabolites or a pharmacodynamic interaction with warfarin. A common response to this interaction, as discussed in previously published case reports, is the discontinuation of warfarin, capecitabine, or both. In this case, the Naranjo probability scale indicates a highly probable drug interaction between warfarin and capecitabine. As more patients require anticoagulation, and as chemotherapy agents such as capecitabine become available, the likelihood for these drug interactions increases. In our patient, close monitoring of therapy allowed successful use of warfarin and capecitabine. JF - The Annals of pharmacotherapy AU - Janney, Laurel M AU - Waterbury, Nancee V AD - Department of Pharmacy Service, Iowa City Veterans Affairs Medical Center, Iowa City, IA 52246-2208, USA. Laurel.Janney@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 1546 EP - 1551 VL - 39 IS - 9 SN - 1060-0280, 1060-0280 KW - Anticoagulants KW - 0 KW - Antimetabolites, Antineoplastic KW - Deoxycytidine KW - 0W860991D6 KW - Warfarin KW - 5Q7ZVV76EI KW - Capecitabine KW - 6804DJ8Z9U KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Heart Valve Prosthesis Implantation KW - Drug Interactions KW - Colonic Neoplasms -- complications KW - Mitral Valve -- surgery KW - Humans KW - International Normalized Ratio KW - Fluorouracil -- analogs & derivatives KW - Colonic Neoplasms -- drug therapy KW - Middle Aged KW - Male KW - Deoxycytidine -- adverse effects KW - Antimetabolites, Antineoplastic -- adverse effects KW - Anticoagulants -- therapeutic use KW - Deoxycytidine -- analogs & derivatives KW - Anticoagulants -- adverse effects KW - Warfarin -- adverse effects KW - Deoxycytidine -- therapeutic use KW - Warfarin -- therapeutic use KW - Antimetabolites, Antineoplastic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68479632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Capecitabine-warfarin+interaction.&rft.au=Janney%2C+Laurel+M%3BWaterbury%2C+Nancee+V&rft.aulast=Janney&rft.aufirst=Laurel&rft.date=2005-09-01&rft.volume=39&rft.issue=9&rft.spage=1546&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-26 N1 - Date created - 2005-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Constructing the Stroke: Sudden-Onset Narratives of Stroke Survivors AN - 60038109; 200620613 AB - In this article, the authors explore the narrative production of stroke from the perspectives of survivors, that is, the stroke itself, not its implications for the individual poststroke. In the vast amount of literature on both sudden onset & chronic illness, the narrative construction of the onset of the illness, for the most part, has been ignored by social scientists, most notably in qualitative research. This is certainly true of stroke. Drawing on existing literature in both chronic illness & the body, the authors extend this to explore the phenomenological construction of stroke onset. Using data gathered from in-depth interviews with 111 stroke survivors postdischarge, they suggest three narrative mechanisms are used in the construct of the sudden-onset event itself: the use of typifications to construct the body during stroke, stroke as an internal communicative act, & stroke as a physical sensation & the mechanisms used to minimize bodily concerns. References. [Reprinted by permission of Sage Publications Inc., copyright 2005.] JF - Qualitative Health Research AU - Faircloth, Christopher A AU - Boylstein, Craig AU - Rittman, Maude AU - Gubrium, Jaber F AD - Rehabilitation Outcomes Research Center, North Florida/South Georgia Veterans Administration Medical Center Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 928 EP - 941 PB - Sage Publications, Thousand Oaks CA VL - 15 IS - 7 SN - 1049-7323, 1049-7323 KW - stroke KW - chronic illness KW - narrative KW - body KW - Chronic Illness KW - Human Body KW - Patients KW - Narratives KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60038109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Qualitative+Health+Research&rft.atitle=Constructing+the+Stroke%3A+Sudden-Onset+Narratives+of+Stroke+Survivors&rft.au=Faircloth%2C+Christopher+A%3BBoylstein%2C+Craig%3BRittman%2C+Maude%3BGubrium%2C+Jaber+F&rft.aulast=Faircloth&rft.aufirst=Christopher&rft.date=2005-09-01&rft.volume=15&rft.issue=7&rft.spage=928&rft.isbn=&rft.btitle=&rft.title=Qualitative+Health+Research&rft.issn=10497323&rft_id=info:doi/10.1177%2F1049732305277842 LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Number of references - 41 N1 - Last updated - 2016-09-28 N1 - CODEN - QHREEM N1 - SubjectsTermNotLitGenreText - Chronic Illness; Human Body; Narratives; Patients DO - http://dx.doi.org/10.1177/1049732305277842 ER - TY - JOUR T1 - Advancing Appraisal: Aphasia and the WHO AN - 57195642; 200611556 AB - Limitations of current methods used in the appraisal of aphasic individuals are reviewed with emphasis on the potential insufficiency of available measures for the focusing of socially valid treatment & the evaluation of its outcomes; consequently, it is urged that aphasia appraisal be situated in the context of the family of international classifications of functioning, disability, & quality of life developed by the World Health Organization (WHO). Relevant component measures, including the International Classification of Functioning, Disability, & Health (ICF) & the long- & short-form WHOQOL quality-of-life instruments, are described & shown to incorporate information lying beyond the scope of disease-specific measures, eg, the Stroke and Aphasia Quality of Life Scale-39. A suggested programmatic approach involves the development of body-, activity-, & participation-level measures, standard protocols for the appraisal of relevant personal & environmental variables, & disease-specific quality-of-life measures with wide scope. Commentary is provided by Katerina Hilari, Claire Penn, Travis T. Threats, & Linda Worrall & Madeline Cruice. Topics addressed include the need to base assessments on empirical knowledge of the constructs being measured; fundamental differences between the ICF & WHOQOL; the failure of WHO protocols to draw on theoretical bases in anthropology, sociology, linguistics, & pragmatics; & the relevance of existing measures to domains identified by patients as significant. The authors' reply examines questions of programmatic vs so-called eclectic appraisal, overall vs health-related quality of life in the scope of appraisals, standardized vs so-called individualized measures, clinical vs research appraisal, & motivations for the development of new measures. 176 References. J. Hitchcock JF - Aphasiology AU - Ross, Katherine B AU - Wertz, Robert T AD - Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ katherine.ross3@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 860 EP - 900 PB - Taylor & Francis Ltd / Psychology Press, Basingstoke UK VL - 19 IS - 9 SN - 0268-7038, 0268-7038 KW - Diagnosis KW - Aphasia KW - Therapy KW - Language disorders KW - Patients KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57195642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Advancing+Appraisal%3A+Aphasia+and+the+WHO&rft.au=Ross%2C+Katherine+B%3BWertz%2C+Robert+T&rft.aulast=Ross&rft.aufirst=Katherine&rft.date=2005-09-01&rft.volume=19&rft.issue=9&rft.spage=860&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/10.1080%2F02687030544000038 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-07-28 N1 - SuppNotes - Comments, 870-893; Reply, 893-900. N1 - Last updated - 2016-09-27 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - Aphasia; Language disorders; Therapy; Patients; Diagnosis DO - http://dx.doi.org/10.1080/02687030544000038 ER - TY - JOUR T1 - Comorbidity Is a Better Predictor of Impaired Immunity than Chronological Age in Older Adults AN - 57091684; 200600134 AB - OBJECTIVES: To determine whether high level of comorbidity, measured using a standardized instrument, can predict impaired immunity in older adults. SETTING: Geriatric outpatient Clinic and Nursing Home Care Unit of Veterans Affairs Greater Los Angeles Healthcare System. PARTICIPANTS: Fifteen men aged 51 to 95 with varying levels of chronic illness. MEASUREMENTS: Disease burden was measured using the Cumulative Illness Rating Scale (CIRS) and immunity using proliferation of T cells induced by phytohemagglutinin (PHA) and production of interleukin (IL)-12, a proinflammatory cytokine that promotes T helper cell-dependent immune response, and IL-10, a cytokine that inhibits T helper cell-dependent immune response, in response to mitogenic stimulation of peripheral blood mononuclear cells. RESULTS: With increasing comorbidity (increase in CIRS score) in older adults, there is a proportional decrease in immune response (decrease in T cell proliferation and IL-12 production and increase in IL-10 production in response to PHA stimulation). Neither immune response nor CIRS score was significantly correlated with chronological age in this sample of older adults with varying degrees of chronic illness. CONCLUSION: This study demonstrates that the level of comorbidity correlates with the magnitude of immune response in older adults and suggests that the CIRS could be used to determine the magnitude of impaired immunity in older adults with different specific illnesses and different levels of severity. Illustrations, Tables, References. Adapted from the source document. JF - Journal of the American Geriatrics Society AU - Castle, Steven Charles AU - Uyemura, Koichi AU - Rafi, Asif AU - Akande, Omosalewa AU - Makinodan, Takashi AD - VA Greater Los Angeles Healthcare System, CA steven.castle@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 1565 EP - 1569 PB - JAGSAF VL - 53 IS - 9 SN - 0002-8614, 0002-8614 KW - immunosenescence KW - interleukin-10 and -12 KW - comorbidity KW - CIRS KW - immunity KW - aging KW - Ageing KW - Elderly people KW - Immune response KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57091684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Comorbidity+Is+a+Better+Predictor+of+Impaired+Immunity+than+Chronological+Age+in+Older+Adults&rft.au=Castle%2C+Steven+Charles%3BUyemura%2C+Koichi%3BRafi%2C+Asif%3BAkande%2C+Omosalewa%3BMakinodan%2C+Takashi&rft.aulast=Castle&rft.aufirst=Steven&rft.date=2005-09-01&rft.volume=53&rft.issue=9&rft.spage=1565&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2005.53512.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JAGSAF N1 - SubjectsTermNotLitGenreText - Comorbidity; Ageing; Immune response; Elderly people DO - http://dx.doi.org/10.1111/j.1532-5415.2005.53512.x ER - TY - JOUR T1 - Association between Parkinson's Disease and Low Bone Density and Falls in Older Men: The Osteoporotic Fractures in Men Study AN - 57081590; 200600263 AB - OBJECTIVES: To examine the association between Parkinson's disease (PD) and bone mineral density (BMD) and risk of falls. DESIGN: Cross-sectional and prospective cohort study. SETTING: Six U.S. clinical centers. PARTICIPANTS: Five thousand nine hundred ninety-five community-dwelling, ambulatory men aged 65 and older. MEASUREMENTS: History of physician-diagnosed PD was ascertained from participant self-report. BMD was measured at the hip and spine using dual energy x-ray absorptiometry (DEXA) and quantitative computed tomography (QCT). Incident falls were ascertained for 1 year using mailed queries. RESULTS: Fifty-two participants (0.9%) reported a history of PD. In multivariate models, PD was associated with significantly lower BMD at the spine (- 4.9%, P = .04) and total hip (- 5.3%, P = .007) using DEXA and at the spine (-6.7%, P =.05) and total hip (-8.2%, P =.03) using QCT. PD was associated with a nearly three times greater age-adjusted risk of multiple future falls (odds ratio (OR) = 2.91, 95% confidence interval (CI) = 1.55-5.46). Further adjustment for history of multiple falls in the year before baseline attenuated this risk, but it remained significant (OR = 2.30, 95% CI = 1.15-4.59). CONCLUSION: In this cohort of older men, PD was associated with lower BMD at the hip and spine, measured using areal and volumetric BMD, as well as increased falls. Clinicians should consider screening older men with PD for osteoporosis. Tables, References. Adapted from the source document. JF - Journal of the American Geriatrics Society AU - Fink, Howard A AU - Kuskowski, Michael A AU - Orwoll, Eric S AU - Cauley, Jane A AU - Ensrud, Kristine E AD - VA Medical Center, Minneapolis, MN howard.fink@med.va.gov Y1 - 2005/09// PY - 2005 DA - September 2005 SP - 1559 EP - 1564 PB - JAGSAF VL - 53 IS - 9 SN - 0002-8614, 0002-8614 KW - Parkinson's disease KW - osteoporosis KW - bone density KW - accidental falls KW - Bone mineral density KW - Falls KW - Osteoporosis KW - Brittle bones KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57081590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Association+between+Parkinson%27s+Disease+and+Low+Bone+Density+and+Falls+in+Older+Men%3A+The+Osteoporotic+Fractures+in+Men+Study&rft.au=Fink%2C+Howard+A%3BKuskowski%2C+Michael+A%3BOrwoll%2C+Eric+S%3BCauley%2C+Jane+A%3BEnsrud%2C+Kristine+E&rft.aulast=Fink&rft.aufirst=Howard&rft.date=2005-09-01&rft.volume=53&rft.issue=9&rft.spage=1559&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2005.53464.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JAGSAF N1 - SubjectsTermNotLitGenreText - Parkinson's disease; Osteoporosis; Falls; Brittle bones; Bone mineral density DO - http://dx.doi.org/10.1111/j.1532-5415.2005.53464.x ER - TY - JOUR T1 - Effect of donors' intravenous drug use, cigarette smoking, and alcohol dependence on kidney transplant outcome. AN - 68517415; 16123722 AB - The shortage of organ donors for kidney transplants has made the expansion of the kidney donor pool a clinically significant issue. Previous studies suggest that kidneys from donors with a history of intravenous (IV) drug, cigarette, and/or alcohol use are considered to be a risky choice. However, these kidneys could potentially be used and expand the kidney supply pool if no evidence shows their association with adverse transplant outcomes. This study analyzed the United Network for Organ Sharing dataset from 1994 to 1999 using Kaplan-Meier survival analysis and Cox modeling. The effects on transplant outcome (graft and recipient survival) were examined with respect to the donors' IV drug use, cigarette smoking, and alcohol dependency. Covariates including the recipient variables, the donor variables, and the transplant procedure variables were included in the Cox models. The results show that the donors' history of cigarette smoking is a statistically significant risk factor for both graft survival (hazard ratio=1.05, P<0.05) and recipient survival (1.06, P<0.05), whereas neither IV drug use nor alcohol dependency had significant adverse impact on graft or recipient survival. Assuming that adequate testing for potential infections is performed, there is no evidence to support avoiding the kidneys from donors with IV drug use or alcohol dependency in transplantation. Utilizing these kidneys would clearly expand the potential pool of donor organs. JF - Transplantation AU - Lin, Shih-jui AU - Koford, James K AU - Baird, Bradley C AU - Hurdle, John F AU - Krikov, Sergey AU - Habib, Arsalan N AU - Goldfarb-Rumyantzev, Alexander S AD - Department Of Medical Informatics, University of Utah Health Sciences Center, and the Geriatric Research, Education, and Clinical Center, Veterans Administration Salt Lake City Healthcare System, Salt Lake City, UT 84112, USA. Y1 - 2005/08/27/ PY - 2005 DA - 2005 Aug 27 SP - 482 EP - 486 VL - 80 IS - 4 SN - 0041-1337, 0041-1337 KW - Index Medicus KW - Humans KW - Retrospective Studies KW - Waiting Lists KW - Survival Rate KW - Risk Factors KW - Incidence KW - Follow-Up Studies KW - Middle Aged KW - Time Factors KW - United States -- epidemiology KW - Female KW - Male KW - Proportional Hazards Models KW - Kidney Transplantation -- statistics & numerical data KW - Kidney Transplantation -- mortality KW - Graft Survival KW - Graft Rejection -- etiology KW - Smoking -- adverse effects KW - Substance Abuse, Intravenous -- complications KW - Graft Rejection -- epidemiology KW - Alcoholism -- complications KW - Tissue Donors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68517415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation&rft.atitle=Effect+of+donors%27+intravenous+drug+use%2C+cigarette+smoking%2C+and+alcohol+dependence+on+kidney+transplant+outcome.&rft.au=Lin%2C+Shih-jui%3BKoford%2C+James+K%3BBaird%2C+Bradley+C%3BHurdle%2C+John+F%3BKrikov%2C+Sergey%3BHabib%2C+Arsalan+N%3BGoldfarb-Rumyantzev%2C+Alexander+S&rft.aulast=Lin&rft.aufirst=Shih-jui&rft.date=2005-08-27&rft.volume=80&rft.issue=4&rft.spage=482&rft.isbn=&rft.btitle=&rft.title=Transplantation&rft.issn=00411337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-15 N1 - Date created - 2005-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanical ventilation exacerbates alveolar macrophage dysfunction in the lungs of ethanol-fed rats. AN - 68532274; 16131854 AB - Patients with alcohol abuse have a two- to three-fold increased risk of acute lung injury and respiratory failure after sepsis or trauma but are also at increased risk of nosocomial pneumonia. Mechanical ventilation exacerbates lung injury during critical illnesses. In this study we tested whether mechanical ventilation of the alcoholic lung promotes on balance a proinflammatory phenotype favoring ventilator-induced lung injury or an immunosuppressive phenotype favoring ventilator-associated pneumonia. Lungs from rats fed an isocaloric diet with or without ethanol (six weeks) were isolated and ventilated ex vivo with a low-volume (protective) or high-volume (injurious) strategy for two hours with or without prior endotoxemia (two hours). In other experiments, rats were subjected to high-volume ventilation in vivo. Airway levels of the proinflammatory cytokines tumor necrosis factor-alpha, macrophage inflammatory protein-2, and interleukin-1beta were determined after mechanical ventilation ex vivo and compared with edematous lung injury after high-volume ventilation in vivo. In parallel, alveolar macrophage phagocytosis of bacteria and secretion of interleukin-12 during ventilation ex vivo and endotoxin-stimulated alveolar macrophage phagocytosis and tumor necrosis factor-alpha secretion in vitro were determined. Ethanol ingestion suppressed the proinflammatory response to injurious mechanical ventilation and did not increase experimental ventilator-induced lung injury. In parallel, ethanol ingestion blunted the innate immune response of alveolar macrophages during injurious ventilation ex vivo and after endotoxin stimulation in vitro. Ethanol ingestion dampens ventilator-induced inflammation but exacerbates macrophage immune dysfunction. These findings could explain at least in part why alcoholic patients are at increased risk of ventilator-associated pneumonia. JF - Alcoholism, clinical and experimental research AU - Kamat, Pradip P AU - Slutsky, Arthur AU - Zhang, Haibo AU - Bechara, Rabih I AU - Brown, Lou Ann S AU - Garcia, Raena C AU - Joshi, Pratibha C AU - Kershaw, Corey D AU - Guidot, David M AD - Atlanta Veterans Administration Medical Center and the Department of Pediatrics, Emory University, Atlanta, Georgia, USA. Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 1457 EP - 1465 VL - 29 IS - 8 SN - 0145-6008, 0145-6008 KW - Inflammation Mediators KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Rats KW - Endotoxemia -- immunology KW - Animals KW - Rats, Sprague-Dawley KW - Inflammation Mediators -- blood KW - Opportunistic Infections -- immunology KW - Lung Injury KW - Tidal Volume -- physiology KW - Salmonella typhimurium -- immunology KW - Male KW - Lung -- immunology KW - Ethanol -- toxicity KW - Positive-Pressure Respiration KW - Alcoholism -- immunology KW - Macrophages, Alveolar -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68532274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Mechanical+ventilation+exacerbates+alveolar+macrophage+dysfunction+in+the+lungs+of+ethanol-fed+rats.&rft.au=Kamat%2C+Pradip+P%3BSlutsky%2C+Arthur%3BZhang%2C+Haibo%3BBechara%2C+Rabih+I%3BBrown%2C+Lou+Ann+S%3BGarcia%2C+Raena+C%3BJoshi%2C+Pratibha+C%3BKershaw%2C+Corey+D%3BGuidot%2C+David+M&rft.aulast=Kamat&rft.aufirst=Pradip&rft.date=2005-08-01&rft.volume=29&rft.issue=8&rft.spage=1457&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-term use of benzodiazepines in participants with comorbid anxiety and alcohol use disorders. AN - 68530917; 16131848 AB - Although the only widely accepted role for benzodiazepines in alcohol dependence is the treatment of withdrawal syndromes, they are frequently prescribed outside of this clinical setting. There is little empirical evidence to guide the rational use of benzodiazepines in the common clinical situation where anxiety disorders are comorbid with alcohol use disorders (AUD). Since January 1989, the Harvard Anxiety Research Program has naturalistically monitored the prospective clinical course of people with anxiety disorders, some of whom had a history of AUD. Earlier research showed that the use of benzodiazepines was not significantly associated with the presence or absence of a history of an AUD over the first year of follow-up. This report extends that investigation. Using standard parametric analytic methods, patterns of benzodiazepine use (routinely prescribed medication and as-needed [PRN] use) among participants receiving benzodiazepine treatment was prospectively examined over the course of 12 years. Differences in benzodiazepine usage patterns were examined in each year of follow-up between participants who did (n=120) and did not (n=425) have a new episode of AUD. Using proportional hazards regression analysis, benzodiazepine usage levels were examined as predictors of recovery and recurrence of AUD. Additionally, random-effects regression analyses were used to examine the patterns of benzodiazepine use before and after the onset of a prospectively observed episode of AUD. Benzodiazepine usage levels remained stable for the full sample over the course of the 12 years. Benzodiazepine use did not distinguish participants who had a new AUD from those who did not. Over the 12 years of follow-up, participants who had an AUD used more PRN medication in years five to eight. This difference reached statistical significance but was not clinically significant. Benzodiazepine usage levels did not predict recovery or recurrence in AUD subjects. Neither the total dose nor the PRN usage of benzodiazepines was significantly associated with the onset of AUD, but when combined into a measure of any benzodiazepine use, a relationship between increased use and the onset of AUD emerged. For participants in the Harvard Anxiety Research Program with comorbid alcohol dependence and anxiety disorders, there was little association between the use of benzodiazepines and the occurrence of a new AUD. Neither was there a temporal relationship between the use of benzodiazepines and the onset of a new AUD. Whether or not this finding extends to a broader patient population or a group of people who present to addictions treatment awaits further investigation. JF - Alcoholism, clinical and experimental research AU - Mueller, Timothy I AU - Pagano, Maria E AU - Rodriguez, Benjamin F AU - Bruce, Steven E AU - Stout, Robert L AU - Keller, Martin B AD - Southern Arizona VA Health Care System, University of Arizona Health Sciences Center, Department of Psychiatry, Tucson, Arizona 85723, USA. timothy.mueller@med.va.gov Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 1411 EP - 1418 VL - 29 IS - 8 SN - 0145-6008, 0145-6008 KW - Benzodiazepines KW - 12794-10-4 KW - Index Medicus KW - Prospective Studies KW - Substance Withdrawal Syndrome -- rehabilitation KW - Humans KW - Adult KW - Middle Aged KW - Long-Term Care KW - Follow-Up Studies KW - Longitudinal Studies KW - Recurrence KW - Male KW - Female KW - Comorbidity KW - Alcoholism -- rehabilitation KW - Benzodiazepines -- adverse effects KW - Alcoholism -- epidemiology KW - Benzodiazepines -- administration & dosage KW - Anxiety Disorders -- rehabilitation KW - Anxiety Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68530917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Long-term+use+of+benzodiazepines+in+participants+with+comorbid+anxiety+and+alcohol+use+disorders.&rft.au=Mueller%2C+Timothy+I%3BPagano%2C+Maria+E%3BRodriguez%2C+Benjamin+F%3BBruce%2C+Steven+E%3BStout%2C+Robert+L%3BKeller%2C+Martin+B&rft.aulast=Mueller&rft.aufirst=Timothy&rft.date=2005-08-01&rft.volume=29&rft.issue=8&rft.spage=1411&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-08-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Subst Abuse. 1992;4(1):19-26 [1320971] J Nerv Ment Dis. 1994 May;182(5):290-6 [10678311] Am J Addict. 2000 Fall;9(4):276-9; discussion 280-4 [11155783] Alcohol Alcohol. 1998 Nov-Dec;33(6):563-75 [9872344] Br J Psychiatry Suppl. 1998;(34):24-8 [9829013] Compr Psychiatry. 1998 Jul-Aug;39(4):176-84 [9675501] Arch Gen Psychiatry. 1997 Apr;54(4):313-21 [9107147] J Fam Pract. 1996 Apr;42(4):342 [8627189] J Clin Psychiatry. 1996 Feb;57(2):83-9 [8591974] J Psychiatr Res. 1994 Nov-Dec;28(6):531-45 [7699612] Am J Psychiatry. 1994 Dec;151(12):1723-34 [7977877] Arch Gen Psychiatry. 1994 Sep;51(9):720-31 [8080349] Am J Psychiatry. 1993 Apr;150(4):600-7 [8465877] Alcohol Clin Exp Res. 1992 Dec;16(6):1007-13 [1335217] J Subst Abuse. 1992;4(2):179-85 [1354514] Psychiatr Serv. 1999 Oct;50(10):1359-61 [10506309] Am J Psychiatry. 2005 Jun;162(6):1179-87 [15930067] Arch Gen Psychiatry. 1990 Oct;47(10):899-907 [2222129] Am J Psychiatry. 1990 Jun;147(6):685-95 [2188513] Am J Psychiatry. 1989 May;146(5):683-4 [2565691] Am J Psychiatry. 1988 Dec;145(12):1501-6 [2904227] Arch Gen Psychiatry. 1987 Jun;44(6):540-8 [3579500] Arch Gen Psychiatry. 1985 Nov;42(11):1050-5 [4051682] Am J Psychiatry. 2003 Aug;160(8):1432-8 [12900305] Depress Anxiety. 2003;17(3):173-9 [12768651] J Clin Psychiatry. 2002 Sep;63(9):756-7 [12363113] Am J Addict. 2001 Winter;10(1):48-68 [11268828] Arch Gen Psychiatry. 1990 Oct;47(10):908-15 [2222130] JAMA. 1990 Nov 21;264(19):2511-8 [2232018] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Season, sun, sex, and cervical cancer. AN - 68480606; 16103441 AB - Sunlight's UV B component, a known cellular immunosupressant, carcinogen, and activator of viral infections, is generally seasonally available. Venereal human papillomavirus (HPV) transmission, at least in part, causes cervical cancer. We have previously inspected the monthly rates of venereal HPV infection and sunlight fluency in Southern Holland over 16 consecutive years. Both peak in August with at least 2-fold seasonality. The amount of available sunlight and the rate of Papanicolaou (Pap) smear screen-detected HPV are positively correlated. We now investigate whether premalignant and malignant cervical epithelial changes are also seasonal and related to seasonal sunlight fluency. We have studied >900,000 consecutive, serially independent, interpretable screening Pap smears obtained by a single cervical cancer screening laboratory in Leiden, Holland, during a continuous 16-year span from 1983 through 1998. The average monthly rates of premalignant and malignant epithelial change were inspected and the annual patterns contrasted to the annual pattern of sunlight fluency at this global location and to monthly average HPV infection rate. Because HPV is venereally transmitted, Dutch seasonal sexual behavior was evaluated by assessment of the annual pattern of Dutch conception frequency as a competing cause for cervical cancer seasonality. (a) Twice as many premalignant and malignant epithelial changes were found among Pap smears obtained in the summer months, with an August peak concurrent with histopathologic evidence of HPV infection and sunlight fluency in Southern Holland. (b) Monthly sunlight fluency is correlated positively with both the monthly rates of Pap smear-detected cervical epithelial dysplasia and carcinomatous histopathology, as well as HPV. (c) Conception frequency, in this location, peaks in Spring not summer, and has a 4.8% annual amplitude. (a) Cervical epithelial HPV infection and HPV-induced cervical epithelial dysplasia and carcinomatous change may each be novel sun exposure risks and thereby behaviorably avoidable. (b) Because screening Pap smears uncover many abnormalities that resolve spontaneously (false positives), these data may argue for screening and follow-up Pap smear examinations in seasons other than summer in the Northern Hemisphere, to diminish the false-positive smear rate. Global data are available to confirm and further test each of these conclusions. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Hrushesky, William J M AU - Sothern, Robert B AU - Rietveld, Wop J AU - Du Quiton, Jovelyn AU - Boon, Mathilde E AD - Department of Epidemiology and Biostatistics, Norman J. Arnold of Public Health, University of South Carolina, Columbia, SC 29209, USA. william.hrushesky@med.va.gov Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 1940 EP - 1947 VL - 14 IS - 8 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Netherlands -- epidemiology KW - Mass Screening KW - Analysis of Variance KW - Humans KW - Adult KW - Vaginal Smears KW - Incidence KW - Female KW - Sex KW - Papanicolaou Test KW - Uterine Cervical Neoplasms -- etiology KW - Uterine Cervical Dysplasia -- pathology KW - Uterine Cervical Neoplasms -- classification KW - Papillomavirus Infections -- epidemiology KW - Uterine Cervical Dysplasia -- etiology KW - Papillomavirus Infections -- complications KW - Papillomaviridae -- isolation & purification KW - Seasons KW - Solar System KW - Uterine Cervical Dysplasia -- virology KW - Uterine Cervical Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68480606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Season%2C+sun%2C+sex%2C+and+cervical+cancer.&rft.au=Hrushesky%2C+William+J+M%3BSothern%2C+Robert+B%3BRietveld%2C+Wop+J%3BDu+Quiton%2C+Jovelyn%3BBoon%2C+Mathilde+E&rft.aulast=Hrushesky&rft.aufirst=William+J&rft.date=2005-08-01&rft.volume=14&rft.issue=8&rft.spage=1940&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-08 N1 - Date created - 2005-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Commentary: Adding to our comprehension of Gulf War health questions. AN - 68444992; 15972305 JF - International journal of epidemiology AU - Hyams, Kenneth Craig AD - Occupational and Environmental Strategic Healthcare Group, Office of Public Health and Environmental Hazards, Department of Veterans Affairs, VA Central Office (13A), 810 Vermont Avenue NW, Washington, DC 20420, USA. kenneth.hyams@va.gov Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 808 EP - 809 VL - 34 IS - 4 SN - 0300-5771, 0300-5771 KW - Index Medicus KW - Veterans KW - Saudi Arabia -- epidemiology KW - Humans KW - Occupational Exposure -- adverse effects KW - United States -- epidemiology KW - Gulf War KW - Military Personnel KW - Occupational Diseases -- epidemiology KW - Persian Gulf Syndrome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68444992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+epidemiology&rft.atitle=Commentary%3A+Adding+to+our+comprehension+of+Gulf+War+health+questions.&rft.au=Hyams%2C+Kenneth+Craig&rft.aulast=Hyams&rft.aufirst=Kenneth&rft.date=2005-08-01&rft.volume=34&rft.issue=4&rft.spage=808&rft.isbn=&rft.btitle=&rft.title=International+journal+of+epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-07 N1 - Date created - 2005-08-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Int J Epidemiol. 2005 Aug;34(4):801-8 [15737976] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mortality in US Army Gulf War veterans exposed to 1991 Khamisiyah chemical munitions destruction. AN - 68075873; 16043669 AB - We investigated whether US Army Gulf War veterans who were potentially exposed to nerve agents during the March 1991 weapons demolitions at Khamisiyah, Iraq, are at increased risk of cause-specific mortality. The cause-specific mortality of 100487 exposed US Army Gulf War veterans was compared with that of 224980 unexposed US Army Gulf War veterans. Exposure was determined with the Department of Defense 2000 plume model. Relative risk estimates were derived from Cox proportional hazards models. The risks of most disease-related mortality were similar for exposed and unexposed veterans. However, exposed veterans had an increased risk of brain cancer deaths (relative risk [RR]=1.94; 95% confidence interval [CI]=1.12, 3.34). The risk of brain cancer death was larger among those exposed 2 or more days than those exposed 1 day when both were compared separately to all unexposed veterans (RR=3.26; 95% CI=1.33, 7.96; RR=1.72; 95% CI=0.95,3.10, respectively). Exposure to chemical munitions at Khamisiyah may be associated with an increased risk of brain cancer death. Additional research is required to confirm this finding. JF - American journal of public health AU - Bullman, Tim A AU - Mahan, Clare M AU - Kang, Han K AU - Page, William F AD - Department of Veterans Affairs, Veterans Health Administration, Mail Stop 135, Environmental Epidemiology Service, 810 Vermont Ave, Washington, DC 20420, USA. tim.bullman@hq.med.va.gov Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 1382 EP - 1388 VL - 95 IS - 8 SN - 0090-0036, 0090-0036 KW - Chemical Warfare Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Risk KW - Humans KW - Adult KW - United States -- epidemiology KW - Male KW - Iraq KW - Female KW - Risk Assessment KW - Proportional Hazards Models KW - Veterans -- statistics & numerical data KW - Gulf War KW - Brain Neoplasms -- mortality KW - Chemical Warfare Agents -- adverse effects KW - Military Personnel -- statistics & numerical data KW - Cause of Death KW - Military Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68075873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Mortality+in+US+Army+Gulf+War+veterans+exposed+to+1991+Khamisiyah+chemical+munitions+destruction.&rft.au=Bullman%2C+Tim+A%3BMahan%2C+Clare+M%3BKang%2C+Han+K%3BPage%2C+William+F&rft.aulast=Bullman&rft.aufirst=Tim&rft.date=2005-08-01&rft.volume=95&rft.issue=8&rft.spage=1382&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-20 N1 - Date created - 2005-07-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 2001 Sep 1;154(5):399-405 [11532780] Lancet. 2000 Jul 1;356(9223):17-21 [10892759] Toxicol Appl Pharmacol. 2002 Oct 15;184(2):82-7 [12408952] Arch Environ Health. 2002 Jul-Aug;57(4):270-2 [12530592] Toxicol Ind Health. 2001 Jun;17(5-10):294-7 [12539875] Am J Epidemiol. 1980 Jan;111(1):99-112 [7352463] Am J Public Health. 1981 Mar;71(3):242-50 [7468855] J Natl Cancer Inst. 1983 Jan;70(1):75-81 [6571925] N Engl J Med. 1987 Apr 23;316(17):1044-50 [3561457] J Natl Cancer Inst. 1987 Aug;79(2):233-8 [3474455] Am J Epidemiol. 1988 Oct;128(4):778-85 [3421243] Am J Epidemiol. 1995 Jan 15;141(2):123-34 [7817968] Neurol Clin. 1996 May;14(2):273-90 [8827171] N Engl J Med. 1996 Nov 14;335(20):1498-504 [8890102] Am J Epidemiol. 1999 Sep 1;150(5):532-40 [10472954] Am J Epidemiol. 2002 May 15;155(10):908-17 [11994230] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identifying a negative mood subtype in incarcerated adolescents: relationship to substance use. AN - 68041783; 16022939 AB - The following study tested the empirical validity and clinical meaningfulness of a negative mood subtype of incarcerated adolescent males (N=270). Differences in alcohol and marijuana use and consequences were examined. Participants were subtyped according to reports of depressive and anxious symptoms using the Children's Depression Inventory and the Revised Children's Manifest Anxiety Scale. Cluster analysis confirmed the presence of negative mood (34%) and normal mood (66%) subtypes. Incarcerated adolescents in the negative mood subtype reported higher levels of alcohol use, higher levels of use-related consequences for both alcohol and marijuana, greater use of both substances to regulate mood states, and more use of avoidant coping. Results underscore the need for identification and treatment of mental health and substance use difficulties in the juvenile justice system. JF - Addictive behaviors AU - Turner, Aaron P AU - Larimer, Mary E AU - Sarason, Irwin G AU - Trupin, Eric W AD - VA Puget Sound Health Care System, and Department of Rehabilitation Medicine, University of Washington, Seattle 98108, United States. Aaron.Turner@med.va.gov Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 1442 EP - 1448 VL - 30 IS - 7 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Adolescent Behavior KW - Marijuana Smoking -- psychology KW - Adaptation, Psychological KW - Humans KW - Alcohol Drinking -- psychology KW - Diagnosis, Dual (Psychiatry) -- psychology KW - Adolescent KW - Psychometrics KW - Cluster Analysis KW - Male KW - Anxiety -- psychology KW - Depression -- psychology KW - Substance-Related Disorders -- psychology KW - Prisoners -- psychology KW - Juvenile Delinquency -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68041783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Identifying+a+negative+mood+subtype+in+incarcerated+adolescents%3A+relationship+to+substance+use.&rft.au=Turner%2C+Aaron+P%3BLarimer%2C+Mary+E%3BSarason%2C+Irwin+G%3BTrupin%2C+Eric+W&rft.aulast=Turner&rft.aufirst=Aaron&rft.date=2005-08-01&rft.volume=30&rft.issue=7&rft.spage=1442&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-22 N1 - Date created - 2005-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Telephone self-monitoring among alcohol use disorder patients in early recovery: a randomized study of feasibility and measurement reactivity. AN - 68014314; 16002033 AB - Frequent symptom self-monitoring protocols have become popular tools in the addiction field. Interactive Voice Response (IVR) is a telephone monitoring system that has been shown to be feasible for collecting frequent self-reports from a variety of research populations. Little is known, however, about the feasibility of using IVR monitoring in clinical samples, and few controlled trials exist assessing the impact of any type of frequent self-report monitoring on the behaviors monitored. This pilot study with patients in early recovery from an alcohol use disorder (n=98) evaluated compliance with two IVR monitoring protocols, subjective experiences with monitoring, and change in symptoms associated with monitoring (i.e., measurement reactivity). Participants were randomly assigned to call an IVR system daily for 28 days, once per week for 4 weeks, or only to complete 28-day follow-up assessment including retrospective drinking reports. Monitoring calls assessed alcohol craving, substance use, emotional well-being, and PTSD symptoms. Most monitoring participants completed calls on at least 75% of scheduled days (72.2% and 59.2% for daily and weekly, respectively). Including reconstructed data from follow-up of missed calls yielded 77.8% and 74.1% of maximum data points, respectively. Most monitoring participants indicated the protocol was manageable and reported positive or no effects of monitoring on urges to use alcohol, actual drinking, and PTSD symptoms. Analyses of measurement reactivity based on assessment one month after randomization found no significant group differences on drinking, craving for alcohol, or PTSD-related symptoms. Results suggest that IVR technology is feasible and appropriate for telephone symptom monitoring in similar clinical samples. JF - Drug and alcohol dependence AU - Simpson, Tracy L AU - Kivlahan, Daniel R AU - Bush, Kristen R AU - McFall, Miles E AD - VISN 20 Mental Illness Research Education and Clinical Center, Seattle, WA 98108, USA. tracy.simpson@med.va.gov Y1 - 2005/08/01/ PY - 2005 DA - 2005 Aug 01 SP - 241 EP - 250 VL - 79 IS - 2 SN - 0376-8716, 0376-8716 KW - Index Medicus KW - Feasibility Studies KW - Analysis of Variance KW - Washington KW - Self Care KW - Patient Compliance KW - Voice KW - Humans KW - Pilot Projects KW - Middle Aged KW - Temperance KW - Male KW - Female KW - Hospitals, Veterans KW - Self Disclosure KW - Telephone KW - Substance Abuse Treatment Centers KW - Alcohol-Related Disorders -- therapy KW - Alcohol-Related Disorders -- psychology KW - Aftercare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68014314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Telephone+self-monitoring+among+alcohol+use+disorder+patients+in+early+recovery%3A+a+randomized+study+of+feasibility+and+measurement+reactivity.&rft.au=Simpson%2C+Tracy+L%3BKivlahan%2C+Daniel+R%3BBush%2C+Kristen+R%3BMcFall%2C+Miles+E&rft.aulast=Simpson&rft.aufirst=Tracy&rft.date=2005-08-01&rft.volume=79&rft.issue=2&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-09 N1 - Date created - 2005-07-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Counseling Utilization by Ethnic Minority College Students AN - 61395075; 200601535 AB - Although multicultural awareness in counseling has risen substantially in the last decade, little research has examined counseling utilization & outcomes for ethnic minorities on university campuses. A sample of 1,166 African American, Asian American, Caucasian, & Latino help-seeking university students from over 40 universities nationwide filled out the Outcome Questionnaire 45 (OQ45) at the first & last therapy sessions. Caucasian students attended significantly more sessions than all other groups. Greatest distress was found at intake in Asian American students, followed by Latino, African American, & Caucasian students. All groups appeared to benefit from therapy, as noted by a decrease in symptomatology, but none of the groups met the criteria for clinically significant change for the OQ45. Implications for therapists working with minority clients are discussed. Tables, References. Adapted from the source document. JF - Cultural Diversity & Ethnic Minority Psychology AU - Kearney, Lisa K AD - South Texas Veterans Health Care System, San Antonio, TX lisa.kearney3@med.va.gov Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 272 EP - 285 VL - 11 IS - 3 SN - 1099-9809, 1099-9809 KW - university students, psychotherapy, treatment research, ethnic minorities KW - Minority Groups KW - Services KW - Psychotherapy KW - Ethnicity KW - College Students KW - Utilization KW - article KW - 6148: problems of minority groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61395075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cultural+Diversity+%26+Ethnic+Minority+Psychology&rft.atitle=Counseling+Utilization+by+Ethnic+Minority+College+Students&rft.au=Kearney%2C+Lisa+K&rft.aulast=Kearney&rft.aufirst=Lisa&rft.date=2005-08-01&rft.volume=11&rft.issue=3&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Cultural+Diversity+%26+Ethnic+Minority+Psychology&rft.issn=10999809&rft_id=info:doi/10.1037%2F1099-9809.11.3.272 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Ethnicity; College Students; Psychotherapy; Minority Groups; Utilization; Services DO - http://dx.doi.org/10.1037/1099-9809.11.3.272 ER - TY - JOUR T1 - TRANSFUSION COMPLICATIONS: Hemolysis during percutaneous mechanical thrombectomy can mimic a hemolytic transfusion reaction AN - 21342879; 6597119 AB - BACKGROUND:Interventional radiologists have developed percutaneous mechanical thrombectomy (PMT) devices to remove intravascular thrombi. Hemolysis, secondary to thrombus destruction from these devices, has been described in radiology journals, but similar reports appear to be lacking in the transfusion medicine literature. Two cases of hemolysis after PMT are described that involved the transfusion service, one of which was reported as a hemolytic transfusion reaction. CASE REPORTS:The first patient received 4 units of red cells (RBCs) during a thrombectomy and subsequent placement of a transjugular intrahepatic portosystemic shunt. The patient developed hemoglobinuria, and it was reported to the blood bank as a possible hemolytic transfusion reaction. After RBC mismatch and bacterial contamination were excluded, the hemolysis was attributed to thrombectomy-related mechanical hemolysis. In the second case, a hemolyzed sample was sent to the blood bank for a type and cross-match. Upon requesting that the sample be redrawn, it was learned that the sample was obtained after PMT. CONCLUSION:Patients who have undergone PMT can have clinical and laboratory findings suggestive of hemolytic transfusion reactions. Although interventional radiologists are familiar with these side effects, the blood bank profession needs to be aware that these procedures cause nonimmune hemolysis and must consider this possibility when evaluating transfusion reactions in these patients. JF - Transfusion AU - Mair, D C AU - Eastlund, T AU - Rosen, G AU - Covin, R AU - Harmon, J V AU - Menser, M AU - Carr, R AU - Shrwany, S AD - Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, the Department of Radiology, the Department of Surgery, and Department of Anesthesiology, University of Minnesota Medical School, Minneapolis, Minnesota; and the Department of Transfusion Medicine, Veterans Administration Hospital, Minneapolis, Minnesota, maird@usa.redcross.org Y1 - 2005/08// PY - 2005 DA - Aug 2005 SP - 1291 EP - 1294 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 45 IS - 8 SN - 0041-1132, 0041-1132 KW - Microbiology Abstracts B: Bacteriology KW - Cross-match KW - Blood KW - Contamination KW - Shunts KW - Hemolysis KW - Transfusion KW - Radiology KW - Side effects KW - Thrombosis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21342879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=TRANSFUSION+COMPLICATIONS%3A+Hemolysis+during+percutaneous+mechanical+thrombectomy+can+mimic+a+hemolytic+transfusion+reaction&rft.au=Mair%2C+D+C%3BEastlund%2C+T%3BRosen%2C+G%3BCovin%2C+R%3BHarmon%2C+J+V%3BMenser%2C+M%3BCarr%2C+R%3BShrwany%2C+S&rft.aulast=Mair&rft.aufirst=D&rft.date=2005-08-01&rft.volume=45&rft.issue=8&rft.spage=1291&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2005.00208.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - SuppNotes - References, 21. N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Cross-match; Blood; Contamination; Shunts; Hemolysis; Radiology; Transfusion; Thrombosis; Side effects DO - http://dx.doi.org/10.1111/j.1537-2995.2005.00208.x ER - TY - JOUR T1 - E. coli virulence factor hemolysin induces neutrophil apoptosis and necrosis/lysis in vitro and necrosis/lysis and lung injury in a rat pneumonia model AN - 19776823; 6278038 AB - Enteric gram-negative bacilli, such as Escherichia coli are the most common cause of nosocomial pneumonia. In this study a wild-type extraintestinal pathogenic strain of E. coli (ExPEC)(CP9) and isogenic derivatives deficient in hemolysin (Hly) and cytotoxic necrotizing factor (CNF) were assessed in vitro and in a rat model of gram-negative pneumonia to test the hypothesis that these virulence factors induce neutrophil apoptosis and/or necrosis/lysis. As ascertained by in vitro caspase-3/7 and LDH activities and neutrophil morphology, Hly mediated neutrophil apoptosis at lower E. coli titers (1 x 10 super(5-6) cfu) and necrosis/lysis at higher titers ( greater than or equal to 1 x 10 super(7) cfu). Data suggest that CNF promotes apoptosis but not necrosis or lysis. We also demonstrate that annexin V/7-amino-actinomycin D staining was an unreliable assessment of apoptosis using live E. coli. The use of caspase-3/7 and LDH activities and neutrophil morphology supported the notion that necrosis, not apoptosis, was the primary mechanism by which neutrophils were affected in our in vivo gram-negative pneumonia model using live E. coli. In addition, in vivo studies demonstrated that Hly mediates lung injury. Neutrophil necrosis was not observed when animals were challenged with purified lipopolysaccharide, demonstrating the importance of using live bacteria. These findings establish that Hly contributes to ExPEC virulence by mediating neutrophil toxicity, with necrosis/lysis being the dominant effect of Hly on neutrophils in vivo and by lung injury. Whether Hly-mediated lung injury is due to neutrophil necrosis, a direct effect of Hly, or both is unclear. JF - American Journal of Physiology: Lung Cellular and Molecular Physiology AU - Russo, Thomas A AU - Davidson, Bruce A AU - Genagon, Stacy A AU - Warholic, Natalie M AU - MacDonald, Ulrike AU - Pawlicki, Patrick D AU - Beanan, Janet M AU - Olson, Ruth AU - Holm, Bruce A AU - Knight, Paul R, III AD - Departments of Medicine and Microbiology, The Witebsky Center for Microbial Pathogenesis, Veterans Administration Western New York Healthcare System, Departments of Anesthesiology, Pathology, and Pediatrics, Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, Buffalo, New York Y1 - 2005/08// PY - 2005 DA - Aug 2005 SP - L207 EP - L216 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA, [mailto:webmaster@the-aps.org], [URL:http://www.the-aps.org/] VL - 289 IS - 2 SN - 1040-0605, 1040-0605 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Apoptosis KW - Data processing KW - virulence factors KW - Injuries KW - Leukocytes (neutrophilic) KW - Toxicity KW - Necrosis KW - Lung KW - Gram-negative bacilli KW - Colony-forming cells KW - Cytotoxic necrotizing factor KW - Escherichia coli KW - Caspase-3 KW - Lipopolysaccharides KW - Hemolysins KW - Annexin V KW - Pneumonia KW - J 02410:Animal Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19776823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.atitle=E.+coli+virulence+factor+hemolysin+induces+neutrophil+apoptosis+and+necrosis%2Flysis+in+vitro+and+necrosis%2Flysis+and+lung+injury+in+a+rat+pneumonia+model&rft.au=Russo%2C+Thomas+A%3BDavidson%2C+Bruce+A%3BGenagon%2C+Stacy+A%3BWarholic%2C+Natalie+M%3BMacDonald%2C+Ulrike%3BPawlicki%2C+Patrick+D%3BBeanan%2C+Janet+M%3BOlson%2C+Ruth%3BHolm%2C+Bruce+A%3BKnight%2C+Paul+R%2C+III&rft.aulast=Russo&rft.aufirst=Thomas&rft.date=2005-08-01&rft.volume=289&rft.issue=2&rft.spage=L207&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.issn=10400605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Apoptosis; Injuries; virulence factors; Leukocytes (neutrophilic); Toxicity; Necrosis; Gram-negative bacilli; Lung; Cytotoxic necrotizing factor; Colony-forming cells; Caspase-3; Lipopolysaccharides; Hemolysins; Pneumonia; Annexin V; Escherichia coli ER - TY - JOUR T1 - A trial of education, prompts, and opinion leaders to improve prescription of lipid modifying therapy by primary care physicians for patients with ischemic heart disease AN - 19553699; 8747538 AB - Background: Recent clinical trials indicate that treatment with lipid modifying therapy improves outcomes in patients with ischemic heart disease (IHD) and low levels of high density lipoprotein (HDL) cholesterol. The results of these trials, however, have not been widely implemented in clinical practice. Objectives: To develop and test an intervention designed to increase the rate of prescription of lipid modifying therapy and to determine the relative effectiveness of three different prompts (progress notes, patient letters, or computer chart reminders). Methods: The study was conducted in 11 US Department of Veterans Affairs Medical Centers. The effect of the intervention on the proportion of eligible patients receiving lipid modifying therapy was compared between five intervention sites and six matched control sites using a controlled before and after study design. Additionally, 92 providers within the intervention clinics were randomized to receive one of the three prompts. Data were analyzed using logistic regression modeling which incorporated terms to account for the clustered nature of the data. Results: At the intervention sites the prescription rate increased from 8.3% during the pre-intervention period to 39.1% during the intervention (OR = 6.5, 95% CI 5.2 to 8.2, p<0.0001) but remained unchanged at the control sites. The interaction between group (control v intervention) and time period was highly significant (p<0.0001). The adjusted odds of receiving a prescription during the intervention period was 3.1 times higher at the intervention sites than at the control sites (95% CI 2.1 to 4.7). Overall, there was no significant difference in prescription rates among the three prompt groups. However, there was a significant interaction between prompt group and site, indicating that the efficacy of the prompts differed by site. Conclusion: An intervention for primary care providers consisting of an educational workshop, opinion leader influence, and prompts substantially increased the prescription rate of lipid modifying therapy. JF - Quality & Safety in Health Care AU - Bloomfield, HE AU - Nelson, D B AU - van Ryn, M AU - Neil, B J AU - Koets, N J AU - Basile, J N AU - Samaha, F F AU - Kaul, R AU - Mehta, J L AU - Bouland, D AD - Center for Chronic Disease Outcomes Research, VA Medical Center, Minneapolis, Minnesota, USA, hanna.bloomfield@med.va.gov Y1 - 2005/08// PY - 2005 DA - Aug 2005 VL - 14 IS - 4 SN - 1475-3898, 1475-3898 KW - Health & Safety Science Abstracts KW - Lipids KW - clinical trials KW - cholesterol KW - heart diseases KW - opinion leaders KW - Education KW - safety engineering KW - Health care KW - intervention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19553699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quality+%26+Safety+in+Health+Care&rft.atitle=A+trial+of+education%2C+prompts%2C+and+opinion+leaders+to+improve+prescription+of+lipid+modifying+therapy+by+primary+care+physicians+for+patients+with+ischemic+heart+disease&rft.au=Bloomfield%2C+HE%3BNelson%2C+D+B%3Bvan+Ryn%2C+M%3BNeil%2C+B+J%3BKoets%2C+N+J%3BBasile%2C+J+N%3BSamaha%2C+F+F%3BKaul%2C+R%3BMehta%2C+J+L%3BBouland%2C+D&rft.aulast=Bloomfield&rft.aufirst=HE&rft.date=2005-08-01&rft.volume=14&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Quality+%26+Safety+in+Health+Care&rft.issn=14753898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - intervention; Lipids; heart diseases; opinion leaders; clinical trials; safety engineering; Education; Health care; cholesterol ER - TY - JOUR T1 - A framework for modeling health behavior protocols and their linkage to behavioral theory AN - 19425497; 6645539 AB - With the rise in chronic, behavior-related disease, computerized behavioral protocols (CBPs) that help individuals improve behaviors have the potential to play an increasing role in the future health of society. To be effective and widely used CBPs should be based on accepted behavioral theory. However, designing CBPs while at the same time specifying their linkages to behavioral theory and developing reusable CBP components (interventions) are challenges to developers of CBPs. Having an ontology with which to describe CBPs could help with these issues. As a first step towards creating such an ontology, we modeled PACE-Adolescent, a theory-based behavioral protocol that uses the Stages of Change Model and Social Cognitive Theory, using PROTEGE-2000, an ontology editor and knowledge acquisition system. We created a three-part knowledge model. Two sub-ontologies described behavioral interventions and psychological theories. The third component, implemented using Guideline Interchange Format (GLIF3), provided a way to describe the structure of a protocol and to link intervention resources and groups of actions to elements of psychological theory. Using this framework, we formally described the PACE-Adolescent protocol. Creating knowledge models such as this may lead to improvements in the design and evaluation of computerized health behavior protocols. JF - Journal of Biomedical Informatics AU - Lenert, Leslie AU - Norman, Gregory J AU - Mailhot, Mark AU - Patrick, Kevin AD - Health Services and Research and Development, Veterans Administration San Diego Healthcare System, USA, llenert@ucsd.edu Y1 - 2005/08// PY - 2005 DA - Aug 2005 SP - 270 EP - 280 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 38 IS - 4 SN - 1532-0464, 1532-0464 KW - Biotechnology and Bioengineering Abstracts KW - Cognitive ability KW - Bioinformatics KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19425497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=A+framework+for+modeling+health+behavior+protocols+and+their+linkage+to+behavioral+theory&rft.au=Lenert%2C+Leslie%3BNorman%2C+Gregory+J%3BMailhot%2C+Mark%3BPatrick%2C+Kevin&rft.aulast=Lenert&rft.aufirst=Leslie&rft.date=2005-08-01&rft.volume=38&rft.issue=4&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2004.12.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Models; Cognitive ability; Bioinformatics DO - http://dx.doi.org/10.1016/j.jbi.2004.12.001 ER - TY - JOUR T1 - Hypoechoic areas on ultrasound images of atheroma are not always diagnostic of fatty plaque AN - 19417416; 6648238 AB - Atherosclerotic plaques in ultrasound (US) images may have bright areas suggestive of fibrous plaque and hypoechoic areas that are often interpreted as fatty plaque. The current study was designed to test the hypothesis that fibrous tissue in atherosclerotic plaques will be hyperechoic or hypoechoic, depending on collagen fiber morphology. Twelve segments of aortic arch containing atherosclerotic plaques obtained from cadavers were imaged with an 8-MHz US transducer, then sectioned, stained with picrosirius red and examined with polarized light microscopy. There were 12 bright areas that contained predominantly thick collagen fibers. Two areas were anechoic, with predominantly thin collagen fibers. There were 11 hypoechoic areas; six of these contained thin fibers and five contained no collagen on polarized light microscopy, suggesting fat or thrombus. We conclude that fibrous aortic plaques consisting of predominantly thin fibers appear hypoechoic or anechoic on US images and, therefore, may be indistinguishable from fatty plaques. (E-mail: Premindra.chandraratnaed.va.gov) JF - Ultrasound in Medicine & Biology AU - Tabel, Ghasan M AU - Hepel, Jaroslaw AU - Whittaker, Peter AU - Palal, Betsy AU - Chandraratna, PAnthony AD - Division of Internal Medicine, University of California, Irvine, CA, USA, Premindra.chandraratna@med.va.gov Y1 - 2005/08// PY - 2005 DA - Aug 2005 SP - 1013 EP - 1015 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 31 IS - 8 SN - 0301-5629, 0301-5629 KW - Biotechnology and Bioengineering Abstracts KW - Fibers KW - Aortic arch KW - Aorta KW - Cadavers KW - Plaques KW - Arteriosclerosis KW - Polarized light KW - Ultrasound KW - Collagen KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19417416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Medicine+%26+Biology&rft.atitle=Hypoechoic+areas+on+ultrasound+images+of+atheroma+are+not+always+diagnostic+of+fatty+plaque&rft.au=Tabel%2C+Ghasan+M%3BHepel%2C+Jaroslaw%3BWhittaker%2C+Peter%3BPalal%2C+Betsy%3BChandraratna%2C+PAnthony&rft.aulast=Tabel&rft.aufirst=Ghasan&rft.date=2005-08-01&rft.volume=31&rft.issue=8&rft.spage=1013&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Medicine+%26+Biology&rft.issn=03015629&rft_id=info:doi/10.1016%2Fj.ultrasmedbio.2005.02.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Fibers; Plaques; Collagen; Ultrasound; Arteriosclerosis; Polarized light; Aortic arch; Cadavers; Aorta DO - http://dx.doi.org/10.1016/j.ultrasmedbio.2005.02.008 ER - TY - JOUR T1 - Is impairment in set-shifting specific to frontal-lobe dysfunction? Evidence from patients with frontal-lobe or temporal-lobe epilepsy. AN - 85398586; pmid-16209428 AB - Frontal-lobe epilepsy (FLE), temporal-lobe epilepsy (TLE), and matched-control subjects were administered the Trail Making Test (TMT) of the Delis-Kaplan Executive Function System (D-KEFS; Delis et al., 2001), which assesses set-shifting on a visuomotor sequencing task. Results indicated that patients with FLE were impaired in both speed and accuracy on the switching condition relative to patients with TLE and controls. The two patient groups did not differ from controls on the four baseline conditions of the test, which assess visual scanning, motor speed, number sequencing, and letter sequencing. In addition, seizure-related variables (i.e., age of seizure onset, duration of epilepsy, and seizure frequency) failed to correlate with set-shifting performance in patients with FLE. These results suggest that patients with FLE can be reliably distinguished from those with TLE and control subjects on set-shifting as measured by the DKEFS TMT. JF - Journal of the International Neuropsychological Society : JINS AU - McDonald, Carrie R AU - Delis, Dean C AU - Norman, Marc A AU - Tecoma, Evelyn S AU - Iragui-Madozi, Vicente I AD - Psychology Service (116B) Delis Lab, Veterans Administration San Diego Healthcare System, 3350 La Jolla Village Drive, La Jolla, CA 92611, USA. camcdonald@ucsd.edu Y1 - 2005/07// PY - 2005 DA - Jul 2005 SP - 477 EP - 481 VL - 11 IS - 4 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Analysis of Variance KW - Case-Control Studies KW - Demography KW - *Epilepsy, Frontal Lobe: physiopathology KW - *Epilepsy, Temporal Lobe: physiopathology KW - Female KW - Functional Laterality: physiology KW - Humans KW - Male KW - *Mental Processes: physiology KW - Middle Aged KW - *Psychomotor Performance: physiology KW - Reaction Time: physiology KW - Trail Making Test: statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85398586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Is+impairment+in+set-shifting+specific+to+frontal-lobe+dysfunction%3F+Evidence+from+patients+with+frontal-lobe+or+temporal-lobe+epilepsy.&rft.au=McDonald%2C+Carrie+R%3BDelis%2C+Dean+C%3BNorman%2C+Marc+A%3BTecoma%2C+Evelyn+S%3BIragui-Madozi%2C+Vicente+I&rft.aulast=McDonald&rft.aufirst=Carrie&rft.date=2005-07-01&rft.volume=11&rft.issue=4&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The neuropsychological impact of sports-related concussion: a meta-analysis. AN - 85398516; pmid-16209414 AB - There is increasing interest in the potential neuropsychological impact of sports-related concussion. A meta-analysis of the relevant literature was conducted to determine the impact of sports-related concussion across six cognitive domains. The analysis was based on 21 studies involving 790 cases of concussion and 2014 control cases. The overall effect of concussion (d = 0.49) was comparable to the effect found in the non-sports-related mild traumatic brain injury population (d = 0.54; Belanger et al., 2005). Using sports-concussed participants with a history of prior head injury appears to inflate the effect sizes associated with the current sports-related concussion. Acute effects (within 24 hr of injury) of concussion were greatest for delayed memory, memory acquisition, and global cognitive functioning (d = 1.00, 1.03, and 1.42, respectively). However, no residual neuropsychological impairments were found when testing was completed beyond 7 days postinjury. These findings were moderated by cognitive domain and comparison group (control group versus preconcussion self-control). Specifically, delayed memory in studies utilizing a control group remained problematic at 7 days. The implications and limitations of these findings are discussed. JF - Journal of the International Neuropsychological Society : JINS AU - Belanger, Heather G AU - Vanderploeg, Rodney D AD - James A. Haley Veterans' Hospital, Physical Medicine and Rehabilitation-117, 13000 Bruce B. Downs Blvd., Tampa, FL 33612, USA. Heather.Belanger@med.va.gov Y1 - 2005/07// PY - 2005 DA - Jul 2005 SP - 345 EP - 357 VL - 11 IS - 4 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - *Athletic Injuries: physiopathology KW - Attention: physiology KW - *Brain Concussion: physiopathology KW - *Cognition: physiology KW - Humans KW - Memory: physiology KW - Neuropsychological Tests KW - *Outcome Assessment (Health Care) KW - Retrospective Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85398516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=The+neuropsychological+impact+of+sports-related+concussion%3A+a+meta-analysis.&rft.au=Belanger%2C+Heather+G%3BVanderploeg%2C+Rodney+D&rft.aulast=Belanger&rft.aufirst=Heather&rft.date=2005-07-01&rft.volume=11&rft.issue=4&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Speech signals used to evaluate functional status of the auditory system. AN - 70131287; 16470466 AB - This review presents a brief history of the evolution of speech audiometry from the 1800s to present day. The two-component aspect of hearing loss (audibility and distortion), which was formalized into a framework in past literature, is presented in the context of speech recognition. The differences between speech recognition in quiet and in background noise are discussed as they relate to listeners with normal hearing and listeners with hearing loss. A discussion of the use of sentence materials versus word materials for clinical use is included as is a discussion of the effects of presentation level on recognition performance in quiet and noise. Finally, the effects of age and hearing loss on speech recognition are considered. JF - Journal of rehabilitation research and development AU - Wilson, Richard H AU - McArdle, Rachel AD - James H. Quillen Department of Veterans Affairs (VA) Medical Center, Mountain Home, TN 37684, USA. richard.wilson2@med.va.gov PY - 2005 SP - 79 EP - 94 VL - 42 IS - 4 Suppl 2 KW - Index Medicus KW - Aging -- physiology KW - Speech Perception -- physiology KW - Hearing Aids -- history KW - History, 21st Century KW - History, 20th Century KW - Speech Reception Threshold Test -- history KW - Humans KW - History, 19th Century KW - Noise -- adverse effects KW - Hearing Loss -- physiopathology KW - Audiometry -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70131287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+rehabilitation+research+and+development&rft.atitle=Speech+signals+used+to+evaluate+functional+status+of+the+auditory+system.&rft.au=Wilson%2C+Richard+H%3BMcArdle%2C+Rachel&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2005-07-01&rft.volume=42&rft.issue=4+Suppl+2&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Journal+of+rehabilitation+research+and+development&rft.issn=1938-1352&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-28 N1 - Date created - 2006-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hearing health and care: the need for improved hearing loss prevention and hearing conservation practices. AN - 70129588; 16470464 AB - Hearing loss affects 31 million Americans, particularly veterans who were exposed to harmful levels of noise during military functions. Many veterans also receive treatment with ototoxic medications, which may exacerbate preexisting hearing loss. Thus, hearing loss is the most common and tinnitus the third most common service-connected disability among veterans. Poor implementation of hearing protection programs and a lack of audiometric testing during medical treatment leave veterans vulnerable to unrecognized and untreated hearing loss until speech communication is impaired. Individualized audiometric testing techniques, including assessment of high frequencies, can be used in clinical and occupational settings to detect early hearing loss. Antioxidants also may alleviate cochlear damage caused by noise and ototoxicity. Ultimately, hearing loss prevention requires education on reducing occupational and recreational noise exposure and counseling on the risks and options available to patients. Technological advances will improve monitoring, allow better noise engineering controls, and lead to more effective hearing protection. JF - Journal of rehabilitation research and development AU - Fausti, Stephen A AU - Wilmington, Debra J AU - Helt, Patrick V AU - Helt, Wendy J AU - Konrad-Martin, Dawn AD - Department of Veterans Affairs (VA) Rehabilitation Research and Development Service, National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Portland, OR 97239, USA. stephen.fausti@med.va.gov PY - 2005 SP - 45 EP - 62 VL - 42 IS - 4 Suppl 2 KW - Anti-Infective Agents KW - 0 KW - Antimalarials KW - Antineoplastic Agents KW - Antioxidants KW - Diuretics KW - Index Medicus KW - Antimalarials -- toxicity KW - Health Services Needs and Demand KW - Anti-Infective Agents -- toxicity KW - Audiometry KW - Humans KW - Counseling KW - Risk Assessment KW - Diuretics -- toxicity KW - Veterans KW - Otoacoustic Emissions, Spontaneous KW - Risk Factors KW - Antioxidants -- therapeutic use KW - Antineoplastic Agents -- toxicity KW - Environmental Exposure KW - Evoked Potentials, Auditory KW - Incidence KW - United States -- epidemiology KW - Tinnitus -- prevention & control KW - Hearing Loss -- diagnosis KW - Tinnitus -- diagnosis KW - Hearing Loss -- epidemiology KW - Tinnitus -- etiology KW - Tinnitus -- epidemiology KW - Hearing Loss -- etiology KW - Hearing Loss -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70129588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+rehabilitation+research+and+development&rft.atitle=Hearing+health+and+care%3A+the+need+for+improved+hearing+loss+prevention+and+hearing+conservation+practices.&rft.au=Fausti%2C+Stephen+A%3BWilmington%2C+Debra+J%3BHelt%2C+Patrick+V%3BHelt%2C+Wendy+J%3BKonrad-Martin%2C+Dawn&rft.aulast=Fausti&rft.aufirst=Stephen&rft.date=2005-07-01&rft.volume=42&rft.issue=4+Suppl+2&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Journal+of+rehabilitation+research+and+development&rft.issn=1938-1352&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-28 N1 - Date created - 2006-02-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuropsychological aspects of coinfection with HIV and hepatitis C virus. AN - 68753445; 16265612 AB - Infection with hepatitis C virus (HCV) is commonly seen in persons with human immunodeficiency virus (HIV) infection, because the viruses share risk factors for transmission; coinfection is a leading cause of morbidity and mortality among HIV-infected persons. Neuropsychological consequences of HIV infection are well established, and studies of HCV-infected persons have revealed neuropsychiatric dysfunction in this population as well. Investigators now are focusing on neuropsychological sequelae of coinfection with HIV and HCV, and preliminary results suggest that coinfection has a possible deleterious effect on global cognitive functioning consistent with frontal-subcortical dysfunction. Data on neuropsychiatric symptoms in coinfected persons are inconclusive at this time and are complicated by important differences in study populations (e.g., injection drug use and disease severity). This review summarizes what is known about neuropsychological aspects of monoinfection with HIV and HCV, as well as coinfection, discusses implications of these findings, and suggests future directions for this research area. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Hilsabeck, Robin C AU - Castellon, Steven A AU - Hinkin, Charles H AD - Psychology Service, South Texas Veterans Health Care System, San Antonio, TX 78229-4404, USA. Robin.Hilsabeck@med.va.gov Y1 - 2005/07/01/ PY - 2005 DA - 2005 Jul 01 SP - S38 EP - S44 VL - 41 Suppl 1 KW - Index Medicus KW - Frontal Lobe -- physiopathology KW - Cognition -- physiology KW - Humans KW - Mental Disorders -- virology KW - Substance-Related Disorders -- complications KW - Frontal Lobe -- chemistry KW - Psychomotor Performance -- physiology KW - HIV Infections -- physiopathology KW - HIV Infections -- complications KW - Cognition Disorders -- virology KW - Hepatitis C -- complications KW - Hepatitis C -- psychology KW - HIV Infections -- psychology KW - Hepatitis C -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68753445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Neuropsychological+aspects+of+coinfection+with+HIV+and+hepatitis+C+virus.&rft.au=Hilsabeck%2C+Robin+C%3BCastellon%2C+Steven+A%3BHinkin%2C+Charles+H&rft.aulast=Hilsabeck&rft.aufirst=Robin&rft.date=2005-07-01&rft.volume=41+Suppl+1&rft.issue=&rft.spage=S38&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-15 N1 - Date created - 2005-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Exp Neuropsychol. 2000 Feb;22(1):16-24 [10649542] Psychiatr Serv. 2000 Feb;51(2):234-8 [10655009] Am J Psychiatry. 2000 May;157(5):683-94 [10784457] J Int Neuropsychol Soc. 2000 Mar;6(3):336-47 [10824505] Am J Psychiatry. 2000 Jun;157(6):867-76 [10831463] Psychosomatics. 2000 Sep-Oct;41(5):377-84 [11015623] N Engl J Med. 2001 Jul 5;345(1):41-52 [11439948] Lancet. 2001 Jul 7;358(9275):38-9 [11454379] Psychosomatics. 2001 Sep-Oct;42(5):411-5 [11739908] Hepatology. 2002 Feb;35(2):433-9 [11826420] Hepatology. 2002 Feb;35(2):440-6 [11826421] J Hepatol. 2002 Mar;36(3):401-7 [11867185] J Hepatol. 2002 Mar;36(3):435-8 [11867190] Gastroenterology. 2002 Aug;123(2):476-82 [12145801] J Hepatol. 2002 Sep;37(3):349-54 [12175630] Psychother Psychosom. 2002 Nov-Dec;71(6):342-9 [12411769] Am J Psychiatry. 2003 Jan;160(1):172-4 [12505819] Psychiatr Serv. 2003 Jun;54(6):827-35 [12773596] J Int Neuropsychol Soc. 2003 Sep;9(6):847-54 [14632243] Psychosomatics. 2004 Jan-Feb;45(1):49-57 [14709760] J Acquir Immune Defic Syndr. 2004 Feb 1;35(2):131-7 [14722444] J Int Neuropsychol Soc. 2004 Jan;10(1):110-3 [14751013] Infection. 2004 Feb;32(1):33-46 [15007741] J Int Neuropsychol Soc. 2004 Mar;10(2):298-300 [15012850] Neurology. 2004 Mar 23;62(6):957-62 [15037699] AIDS. 2004 Jan 2;18(1):1-12 [15090824] Blood. 2004 May 15;103(10):3854-9 [14739225] Ann Neurol. 1986 Jun;19(6):525-35 [3014994] Neurology. 1992 Oct;42(10):1924-30 [1407574] Acta Neurol Scand. 1993 Aug;88(2):112-8 [8213054] J Neuropsychiatry Clin Neurosci. 1995 Spring;7(2):180-7 [7626961] Addict Behav. 1995 Sep-Oct;20(5):685-90 [8712065] Compr Psychiatry. 1997 May-Jun;38(3):146-54 [9154370] J Int Neuropsychol Soc. 1995 May;1(3):304-15 [9375225] J Int Neuropsychol Soc. 1995 Nov;1(6):575-80 [9375245] J Neuropsychiatry Clin Neurosci. 1998 Summer;10(3):320-9 [9706540] Neurology. 1999 Jan 1;52(1):100-8 [9921855] J Int Neuropsychol Soc. 1999 Jan;5(1):41-7 [9989023] Am J Gastroenterol. 1999 May;94(5):1355-60 [10235218] Neuropsychology. 1999 Apr;13(2):306-16 [10353380] Hepatology. 1999 Oct;30(4):1054-8 [10498659] J Virol. 1999 Nov;73(11):9213-21 [10516029] J Int Neuropsychol Soc. 2005 Jan;11(1):16-22 [15686604] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Deterioration following alcohol-use disorder treatment in project MATCH. AN - 68715117; 16240559 AB - This study examines the prevalence and predictors of deterioration during the three months following treatment in Project MATCH (Matching Alcoholism Treatments to Client Heterogeneity), a multisite clinical trial of three different treatments for alcohol-use disorders. The outpatient and aftercare samples of Project MATCH were examined to identify the prevalence of deterioration, as reflected by a decline in percent days abstinent between the 3 months prior to baseline and the 3 months immediately following treatment. Analyses of predictors of deterioration were based on baseline sociodemographic and psychological factors, including substance-related and psychiatric symptoms and treatment-related factors, including treatment type, treatment duration and therapeutic alliance. Approximately 10% (91/927) of patients in the outpatient sample and 7% (50/738) of patients in the aftercare sample deteriorated in the 3 months following treatment. Primary predictors of deterioration in the outpatient sample were lower baseline severity of alcohol dependence, higher baseline depression, fewer sessions of treatment and lower ratings of therapeutic alliance. The only factor associated with deterioration in the aftercare sample was fewer sessions of treatment. Despite the general positive response of patients to alcohol-use disorder treatment, researchers and treatment providers need to be aware of the potential for deterioration in a sizable minority of patients. Potential methods for identifying patients at risk for deterioration early in treatment are discussed. JF - Journal of studies on alcohol AU - Ilgen, Mark AU - Moos, Rudolf AD - Centerfor Health Care Evaluation, Department of Veterans Affairs, Palo Alto Health Care System and Stanford University School of Medicine, 795 Willow Road (MPD 152), Menlo Park, CA 94025, USA. Mark.Ilgen@med.va.gov Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 517 EP - 525 VL - 66 IS - 4 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Socioeconomic Factors KW - Demography KW - Treatment Failure KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Temperance KW - Male KW - Female KW - Prevalence KW - Alcoholism -- epidemiology KW - Alcoholism -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68715117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Deterioration+following+alcohol-use+disorder+treatment+in+project+MATCH.&rft.au=Ilgen%2C+Mark%3BMoos%2C+Rudolf&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2005-07-01&rft.volume=66&rft.issue=4&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic determinants of addiction to opioids and cocaine. AN - 68524660; 16126608 AB - The completion of the human genome sequence has spurred investigation of the genetic contribution to substance dependence. In this article some of the recent scientific evidence for genetic determinants of opioid and cocaine dependence is reviewed. An electronic search of the medical literature was conducted to locate published studies relevant to the genetics of opioid and cocaine dependence. The collected information judged to be most pertinent is described and discussed. Genetic epidemiologic studies support a high degree of heritable vulnerability for both opioid and cocaine dependence. Polymorphisms in the genes coding for dopamine receptors and transporter, opioid receptors, endogenous opioid peptides, cannabinoid receptors, and serotonin receptors and transporter all appear to be associated with the phenotypic expression of this vulnerability once opioids or cocaine are consumed. Despite this initial progress, identification of specific genes and quantification of associated risk for the expression of each gene remain to be elucidated. While alteration of an individual's genome to change the phenotype seems remote, future interventions for treatment of opioid and cocaine dependence may include precise medications targeted to block the effects of proteins that have been identified through genetic research. JF - Harvard review of psychiatry AU - Saxon, Andrew J AU - Oreskovich, Michael R AU - Brkanac, Zoran AD - Department of Psychiatry, University of Washington School of Medicine; Center of Excellence in Substance Abuse Treatment and Education, VA Puget Sound Health Care System, Seattle, WA 98108, USA. Andrew.Saxon@med.va.gov PY - 2005 SP - 218 EP - 232 VL - 13 IS - 4 SN - 1067-3229, 1067-3229 KW - Dopamine Plasma Membrane Transport Proteins KW - 0 KW - Receptors, Dopamine KW - Receptors, Opioid KW - Index Medicus KW - Dopamine Plasma Membrane Transport Proteins -- genetics KW - Polymorphism, Genetic -- genetics KW - Humans KW - Receptors, Dopamine -- genetics KW - Receptors, Opioid -- genetics KW - Gene Library KW - Cocaine-Related Disorders -- genetics KW - Opioid-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68524660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Harvard+review+of+psychiatry&rft.atitle=Genetic+determinants+of+addiction+to+opioids+and+cocaine.&rft.au=Saxon%2C+Andrew+J%3BOreskovich%2C+Michael+R%3BBrkanac%2C+Zoran&rft.aulast=Saxon&rft.aufirst=Andrew&rft.date=2005-07-01&rft.volume=13&rft.issue=4&rft.spage=218&rft.isbn=&rft.btitle=&rft.title=Harvard+review+of+psychiatry&rft.issn=10673229&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-03 N1 - Date created - 2005-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Recent advances in alcohol-induced adduct formation. AN - 68455855; 16088993 JF - Alcoholism, clinical and experimental research AU - Freeman, Thomas L AU - Tuma, Dean J AU - Thiele, Geoffrey M AU - Klassen, Lynell W AU - Worrall, Simon AU - Niemelä, Onni AU - Parkkila, Seppo AU - Emery, Peter W AU - Preedy, Victor R Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 1310 EP - 1316 VL - 29 IS - 7 KW - DNA Adducts KW - 0 KW - Ethanol KW - 3K9958V90M KW - Malondialdehyde KW - 4Y8F71G49Q KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Malondialdehyde -- metabolism KW - Alcohol-Related Disorders -- physiopathology KW - Animals KW - Liver -- physiopathology KW - Cardiomyopathy, Alcoholic -- physiopathology KW - Humans KW - Muscle, Skeletal -- physiopathology KW - Liver Diseases, Alcoholic -- physiopathology KW - Myocardium -- metabolism KW - Muscular Diseases -- physiopathology KW - DNA Adducts -- physiology KW - Lipid Peroxidation -- drug effects KW - Acetaldehyde -- toxicity KW - Ethanol -- toxicity KW - Acetaldehyde -- metabolism KW - Ethanol -- metabolism KW - Alcoholism -- physiopathology KW - DNA Adducts -- drug effects KW - Lipid Peroxidation -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68455855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Recent+advances+in+alcohol-induced+adduct+formation.&rft.au=Freeman%2C+Thomas+L%3BTuma%2C+Dean+J%3BThiele%2C+Geoffrey+M%3BKlassen%2C+Lynell+W%3BWorrall%2C+Simon%3BNiemel%C3%A4%2C+Onni%3BParkkila%2C+Seppo%3BEmery%2C+Peter+W%3BPreedy%2C+Victor+R&rft.aulast=Freeman&rft.aufirst=Thomas&rft.date=2005-07-01&rft.volume=29&rft.issue=7&rft.spage=1310&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-11 N1 - Date created - 2005-08-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A temporal and dose-response association between alcohol consumption and medication adherence among veterans in care. AN - 68082724; 16046874 AB - Previous studies have shown that alcohol consumption is associated with decreased medication adherence, but this association may be confounded by characteristics common among those who drink heavily and those who fail to adhere (e.g., illicit drug use). Our objective was to determine whether there are temporal and dose-response relationships between alcohol consumption and poor adherence. We administered telephone interview surveys to participants in the Veterans Aging Cohort Study, an eight-site observational study of HIV+ and matched HIV- veterans in care, to determine whether alcohol consumption on a particular day was associated with nonadherence to prescribed medications on that same day. We used the Time Line Follow Back to measure alcohol consumption and the Time Line Follow Back Modified for Adherence to measure adherence. Individuals were categorized as abstainers (no alcohol in past 30 days), nonbinge drinkers (alcohol in past 30 days but or =five standard drinks on at least one day). Among 2702 respondents, 1582 (56.6%) were abstainers, 931 (34.5%) were nonbinge drinkers, and 239 (8.9%) were binge drinkers. Abstainers missed medication doses on 2.4% of surveyed days. Nonbinge drinkers missed doses on 3.5% of drinking days, 3.1% of postdrinking days, and 2.1% of nondrinking days (p < 0.001 for trend), and this trend was more pronounced among HIV+ individuals than HIV- individuals. Binge drinkers missed doses on 11.0% of drinking days, 7.0% of postdrinking days, and 4.1% of nondrinking days (p < 0.001 for trend), and this trend was comparably strong for HIV+ and HIV- individuals. Among veterans in care, self-reported alcohol consumption demonstrates a temporal and dose-response relationship to poor adherence. HIV+ individuals may be particularly sensitive to alcohol consumption. JF - Alcoholism, clinical and experimental research AU - Braithwaite, R Scott AU - McGinnis, Kathleen A AU - Conigliaro, Joseph AU - Maisto, Stephen A AU - Crystal, Stephen AU - Day, Nancy AU - Cook, Robert L AU - Gordon, Adam AU - Bridges, Michael W AU - Seiler, Jason F S AU - Justice, Amy C AD - West Haven Veterans Administration Medical Center and Yale University School of Medicine, West Haven, Connecticut 06516, USA. Ronald.brathwaite@med.va.gov Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 1190 EP - 1197 VL - 29 IS - 7 SN - 0145-6008, 0145-6008 KW - Anti-HIV Agents KW - 0 KW - Index Medicus KW - Humans KW - Cohort Studies KW - Interviews as Topic KW - Middle Aged KW - Statistics as Topic KW - Longitudinal Studies KW - Alcoholism -- psychology KW - Male KW - Female KW - HIV Seropositivity -- psychology KW - Veterans -- psychology KW - Anti-HIV Agents -- administration & dosage KW - Alcohol Drinking -- psychology KW - Alcohol Drinking -- adverse effects KW - HIV Seropositivity -- drug therapy KW - Treatment Refusal -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68082724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=A+temporal+and+dose-response+association+between+alcohol+consumption+and+medication+adherence+among+veterans+in+care.&rft.au=Braithwaite%2C+R+Scott%3BMcGinnis%2C+Kathleen+A%3BConigliaro%2C+Joseph%3BMaisto%2C+Stephen+A%3BCrystal%2C+Stephen%3BDay%2C+Nancy%3BCook%2C+Robert+L%3BGordon%2C+Adam%3BBridges%2C+Michael+W%3BSeiler%2C+Jason+F+S%3BJustice%2C+Amy+C&rft.aulast=Braithwaite&rft.aufirst=R&rft.date=2005-07-01&rft.volume=29&rft.issue=7&rft.spage=1190&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-11 N1 - Date created - 2005-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Madarosis and facial alopecia presumed secondary to botulinum a toxin injections. AN - 68078131; 16044070 AB - : Botulinum neurotoxins are considered relatively safe therapy for treatment of inappropriate muscle spasms. As seen in this report, undesirable consequences may result. : The author conducted a clinical interview and examination of the patient. : Unilateral left-sided madarosis and facial alopecia were observed in a patient undergoing botulinum A toxin injections for the treatment of left oromandibular dystonia. The patient had started treatment 18 months previously. He received injections every 3 months in the left masseter and left temporalis muscles. He first noted loss of his left sideburn 8 months into treatment. After 10 months of treatment, he noted that he no longer needed to shave on the left side of his face. Eighteen months after receiving his first botulinum toxin injection, madarosis of the temporal aspect of the left lower lid was observed. : This is the first case report documenting an idiosyncratic unilateral madarosis and facial alopecia as adverse side effects presumed secondary to botulinum A toxin injections. JF - Optometry and vision science : official publication of the American Academy of Optometry AU - Kowing, Dianne AD - William Chappell Jr. VA Outpatient Clinic, Daytona Beach, FL 32114-1495, USA. Diane.Dowing@med.va.gov Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 579 EP - 582 VL - 82 IS - 7 SN - 1040-5488, 1040-5488 KW - Anti-Dyskinesia Agents KW - 0 KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Index Medicus KW - Humans KW - Injections -- adverse effects KW - Middle Aged KW - Mandibular Diseases -- drug therapy KW - Dystonia -- drug therapy KW - Visual Acuity KW - Male KW - Botulinum Toxins -- administration & dosage KW - Anti-Dyskinesia Agents -- adverse effects KW - Anti-Dyskinesia Agents -- administration & dosage KW - Botulinum Toxins -- adverse effects KW - Eyelid Diseases -- chemically induced KW - Alopecia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68078131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Optometry+and+vision+science+%3A+official+publication+of+the+American+Academy+of+Optometry&rft.atitle=Madarosis+and+facial+alopecia+presumed+secondary+to+botulinum+a+toxin+injections.&rft.au=Kowing%2C+Dianne&rft.aulast=Kowing&rft.aufirst=Dianne&rft.date=2005-07-01&rft.volume=82&rft.issue=7&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Optometry+and+vision+science+%3A+official+publication+of+the+American+Academy+of+Optometry&rft.issn=10405488&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-13 N1 - Date created - 2005-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Manganese superoxide dismutase and inducible nitric oxide synthase modify early oxidative events in acute adriamycin-induced mitochondrial toxicity. AN - 68039046; 16020663 AB - In the present study, we used genetically engineered B6C3 mice [mice overexpressing manganese superoxide dismutase (TgM(+/+)), mice in which inducible nitric oxide synthase had been inactivated (iNOSKO(-/-)), and crosses of these two genotypes] to study the role of manganese superoxide dismutase (MnSOD) and inducible nitric oxide synthase (iNOS) in the development of acute Adriamycin-induced cardiotoxicity. Both nontransgenic and genetically engineered mice were treated with 20 mg/kg Adriamycin and cardiac left ventricular tissues studied at 0, 3, 6, and 24 hours. Ultrastructural damage and levels of 4-hydroxy-2-nonenal (4HNE) protein adducts and 3-nitrotyrosine (3NT) were determined in cardiomyocytes using immunogold ultrastructural techniques. Our previous results showed that Adriamycin caused mitochondrial injury without significant nuclear or cytoplasmic damage at early time points. Interestingly, overexpression of MnSOD protected against acute mitochondrial injury, whereas deficiency in iNOS potentiated mitochondrial injury in comparison with levels of injury present in cardiomyocyte mitochondria of nontransgenic mice. In TgM(+/+) mice, there was a significant inverse correlation between mitochondrial injury and 4HNE/3NT levels at all time points analyzed, suggesting that reactive oxygen species/reactive nitrogen species damage products directly regulated acute Adriamycin-induced mitochondrial injury in these mice. The present studies are the first to directly quantify the effects of MnSOD and iNOS on mitochondrial injury during acute Adriamycin-induced cardiotoxicity and show extensive and specific patterns of posttranslational modifications of mitochondrial proteins following Adriamycin treatment. JF - Molecular cancer therapeutics AU - Chaiswing, Luksana AU - Cole, Marsha P AU - Ittarat, Wanida AU - Szweda, Luke I AU - St Clair, Daret K AU - Oberley, Terry D AD - Department of Pathology and Laboratory Medicine, William S. Middleton Memorial Veterans Administration Hospital, Madison, WI 53705, USA. Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 1056 EP - 1064 VL - 4 IS - 7 SN - 1535-7163, 1535-7163 KW - Actins KW - 0 KW - Aldehydes KW - Nitrates KW - Reactive Oxygen Species KW - 3-nitrotyrosine KW - 3604-79-3 KW - Tyrosine KW - 42HK56048U KW - Doxorubicin KW - 80168379AG KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - 4-hydroxy-2-nonenal KW - K1CVM13F96 KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Myocytes, Cardiac -- drug effects KW - Aldehydes -- analysis KW - Actins -- drug effects KW - Actins -- metabolism KW - Mice KW - Myocytes, Cardiac -- pathology KW - Nitrates -- blood KW - Mice, Inbred Strains KW - Blotting, Western KW - Mice, Mutant Strains KW - Blotting, Southern KW - Aldehydes -- metabolism KW - Tyrosine -- metabolism KW - Tyrosine -- analogs & derivatives KW - Male KW - Oxidative Stress KW - Superoxide Dismutase -- metabolism KW - Superoxide Dismutase -- genetics KW - Mitochondria, Heart -- drug effects KW - Superoxide Dismutase -- drug effects KW - Doxorubicin -- toxicity KW - Mitochondria, Heart -- metabolism KW - Mitochondria, Heart -- ultrastructure KW - Mitochondria, Heart -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68039046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Manganese+superoxide+dismutase+and+inducible+nitric+oxide+synthase+modify+early+oxidative+events+in+acute+adriamycin-induced+mitochondrial+toxicity.&rft.au=Chaiswing%2C+Luksana%3BCole%2C+Marsha+P%3BIttarat%2C+Wanida%3BSzweda%2C+Luke+I%3BSt+Clair%2C+Daret+K%3BOberley%2C+Terry+D&rft.aulast=Chaiswing&rft.aufirst=Luksana&rft.date=2005-07-01&rft.volume=4&rft.issue=7&rft.spage=1056&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-23 N1 - Date created - 2005-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improving the rates of quitting smoking for veterans with posttraumatic stress disorder. AN - 67991238; 15994714 AB - Smoking is highly prevalent and refractory among people with posttraumatic stress disorder (PTSD). This study aimed to improve the rate of quitting smoking for veterans with PTSD by integrating treatment for nicotine dependence into mental health care. Smokers undergoing treatment for PTSD (N=66) were randomly assigned to 1) tobacco use treatment delivered by mental health providers and integrated with psychiatric care (integrated care) versus 2) cessation treatment delivered separately from PTSD care by smoking-cessation specialists (usual standard of care). Seven-day point prevalence abstinence was the primary outcome, measured at 2, 4, 6, and 9 months after random assignment. Data were analyzed by using a generalized estimating equations approach following the intent-to-treat principle. Subjects assigned to integrated care were five times more likely than subjects undergoing the usual standard of care to abstain from smoking across follow-up assessment intervals (odds ratio=5.23). Subjects in the integrated care condition were significantly more likely than subjects in usual standard of care to receive transdermal nicotine and nicotine gum. They also received a greater number of smoking-cessation counseling sessions. Stopping smoking was not associated with worsening symptoms of PTSD or depression. Smoking-cessation interventions can be safely incorporated into routine mental health care for PTSD and are more effective than treatment delivered separately by a specialized smoking-cessation clinic. Integrating cessation treatment into psychiatric care may have the potential for improving smoking quit rates in other populations of chronically mentally ill smokers. JF - The American journal of psychiatry AU - McFall, Miles AU - Saxon, Andrew J AU - Thompson, Charles E AU - Yoshimoto, Dan AU - Malte, Carol AU - Straits-Troster, Kristy AU - Kanter, Evan AU - Zhou, Xiao-Hua Andrew AU - Dougherty, Cynthia M AU - Steele, Bonnie AD - PTSD Programs (S-116 MHC), VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA 98108, USA. miles.mcfall@med.va.gov Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 1311 EP - 1319 VL - 162 IS - 7 SN - 0002-953X, 0002-953X KW - Psychotropic Drugs KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Patient Satisfaction KW - Combined Modality Therapy KW - Tobacco Use Disorder -- therapy KW - Tobacco Use Disorder -- epidemiology KW - Humans KW - Psychotropic Drugs -- therapeutic use KW - Psychotherapy -- methods KW - Comorbidity KW - Quality Assurance, Health Care KW - Treatment Outcome KW - Tobacco Use Disorder -- psychology KW - Follow-Up Studies KW - Middle Aged KW - Female KW - Male KW - Prevalence KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Stress Disorders, Post-Traumatic -- therapy KW - Stress Disorders, Post-Traumatic -- psychology KW - Veterans -- psychology KW - Smoking Cessation -- methods KW - Smoking -- prevention & control KW - Smoking -- epidemiology KW - Smoking Cessation -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67991238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Improving+the+rates+of+quitting+smoking+for+veterans+with+posttraumatic+stress+disorder.&rft.au=McFall%2C+Miles%3BSaxon%2C+Andrew+J%3BThompson%2C+Charles+E%3BYoshimoto%2C+Dan%3BMalte%2C+Carol%3BStraits-Troster%2C+Kristy%3BKanter%2C+Evan%3BZhou%2C+Xiao-Hua+Andrew%3BDougherty%2C+Cynthia+M%3BSteele%2C+Bonnie&rft.aulast=McFall&rft.aufirst=Miles&rft.date=2005-07-01&rft.volume=162&rft.issue=7&rft.spage=1311&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-17 N1 - Date created - 2005-07-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A phase II study of flavopiridol in patients with advanced renal cell carcinoma: results of Southwest Oncology Group Trial 0109. AN - 67805490; 15791454 AB - Flavopiridol is a cyclin-dependent kinase inhibitor that prevents cell cycle progression and tumor growth. In initial phase I studies, encouraging responses were seen in advanced renal cell cancer (RCC). In a phase II study of flavopiridol given as a 72-h continuous infusion every 2 weeks in RCC, a response rate of 6% was seen but with considerable grade 3 or 4 asthenia, diarrhea, and thrombosis. Subsequently, an alternative 1-h bolus schedule was reported to have enhanced tolerability in a phase I trial. We therefore conducted a phase II study of this bolus regimen. A total of 38 patients with advanced RCC were entered into this multi-institutional phase II study. Flavopiridol (50 mg/m(2) per day) was administered by bolus intravenous injection daily for three consecutive days, repeated every 3 weeks. Out of 34 eligible patients, one complete response and three partial responses were observed, for an overall response rate of 12% (95% CI 3-27%). Of the 34 patients, 14 (41%) had stable disease (SD). The probability of not failing treatment by 6 months was 21% (95% CI 9-35%). Median overall survival time was 9 months (95% CI 8-18 months). The most common grade 3 or 4 toxicities were diarrhea (35%) and tumor pain (12%) along with anemia, dyspnea, and fatigue (9% each). Flavopiridol at this dose and schedule is feasible with an acceptable toxicity profile. Flavopiridol has some modest biologic activity against advanced RCC, as evidenced by its single-agent objective response and SD rates. JF - Cancer chemotherapy and pharmacology AU - Van Veldhuizen, Peter J AU - Faulkner, James R AU - Lara, Primo N AU - Gumerlock, Paul H AU - Goodwin, J Wendall AU - Dakhil, Shaker R AU - Gross, Howard M AU - Flanigan, Robert C AU - Crawford, E David AU - Southwest Oncology Group AD - University of Kansas Medical Center, Kansas City, KS, USA. peter.vanveldhuizen@med.va.gov ; Southwest Oncology Group Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 39 EP - 45 VL - 56 IS - 1 SN - 0344-5704, 0344-5704 KW - Antineoplastic Agents KW - 0 KW - Flavonoids KW - Piperidines KW - alvocidib KW - 45AD6X575G KW - Index Medicus KW - Drug Administration Schedule KW - Diarrhea -- chemically induced KW - Injections, Intravenous KW - Pain -- chemically induced KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Male KW - Female KW - Survival Analysis KW - Carcinoma, Renal Cell -- pathology KW - Kidney Neoplasms -- pathology KW - Kidney Neoplasms -- drug therapy KW - Piperidines -- therapeutic use KW - Antineoplastic Agents -- administration & dosage KW - Flavonoids -- adverse effects KW - Piperidines -- administration & dosage KW - Carcinoma, Renal Cell -- drug therapy KW - Antineoplastic Agents -- therapeutic use KW - Piperidines -- adverse effects KW - Flavonoids -- therapeutic use KW - Flavonoids -- administration & dosage KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67805490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=A+phase+II+study+of+flavopiridol+in+patients+with+advanced+renal+cell+carcinoma%3A+results+of+Southwest+Oncology+Group+Trial+0109.&rft.au=Van+Veldhuizen%2C+Peter+J%3BFaulkner%2C+James+R%3BLara%2C+Primo+N%3BGumerlock%2C+Paul+H%3BGoodwin%2C+J+Wendall%3BDakhil%2C+Shaker+R%3BGross%2C+Howard+M%3BFlanigan%2C+Robert+C%3BCrawford%2C+E+David%3BSouthwest+Oncology+Group&rft.aulast=Van+Veldhuizen&rft.aufirst=Peter&rft.date=2005-07-01&rft.volume=56&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=03445704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-05 N1 - Date created - 2005-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Influence of Partner Status, Relationship Quality and Relationship Stability on Outcomes Following Intensive Substance-Use Disorder Treatment AN - 57089067; 200600866 AB - Objective: Addiction treatment studies examining the influence of patients' partners suggest that partner behaviors affect patients' substance-use outcomes. We examine the influence of having a partner at treatment entry as well as the influence of the general quality of support and substance-using status of the partner, on outcomes following treatment for substance-use disorder. We also examine the influence of relationship stability on treatment outcomes and examine baseline partner behaviors that may predict relationship stability. Method: A prospective, intact-group design was utilized with data analyzed using logistic regression. Participants (N = 3,014) from 15 intensive substance-use disorder treatment programs were assessed at treatment entry and 1-year postdischarge. Results: Although patients with partners possessed a more favorable clinical profile, their outcomes were no better than those of their single counterparts. However, patients whose relationships lasted through the first year posttreatment had better outcomes than patients whose relationships ended. Relationships with more positive partner behaviors and fewer negative partner behaviors at intake were more likely to remain intact over the course of the first year posttreatment. Positive partner behaviors did not enhance patients' outcomes directly, but partner interpersonal stressors and patients' belief that their partner had a substance-use problem had a significant, deleterious impact on patients' substance-use outcomes. Conclusions: Clinicians should routinely assess the quality of patients' relationships with partners. If deleterious partner behaviors exist, empirically supported interventions (e.g., behavioral couples therapy) could be utilized to reduce these behaviors and ultimately reduce relapse risk. Tables, References. Adapted from the source document. JF - Journal of Studies on Alcohol AU - Tracy, Stephen W AU - Kelly, John F AU - Moos, Rudolf H AD - Center Health Care Evaluation, Veterans Affairs Palo Alto Health Care System, Stanford U School of Medicine, stephen.tracy@med.va.gov Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 497 EP - 505 VL - 66 IS - 4 SN - 0096-882X, 0096-882X KW - Quality assessment KW - Interpersonal relationships KW - Interventions KW - Addiction KW - Treatment KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57089067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol&rft.atitle=The+Influence+of+Partner+Status%2C+Relationship+Quality+and+Relationship+Stability+on+Outcomes+Following+Intensive+Substance-Use+Disorder+Treatment&rft.au=Tracy%2C+Stephen+W%3BKelly%2C+John+F%3BMoos%2C+Rudolf+H&rft.aulast=Tracy&rft.aufirst=Stephen&rft.date=2005-07-01&rft.volume=66&rft.issue=4&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JSALDP N1 - SubjectsTermNotLitGenreText - Interventions; Treatment; Addiction; Interpersonal relationships; Substance abuse; Quality assessment ER - TY - JOUR T1 - Septicemia, access and cardiovascular disease in dialysis patients: The USRDS Wave 2 Study AN - 19286838; 6405809 AB - Background. Microinflammation is linked to cardiovascular disease, and is highly prevalent in dialysis patients. It is logical to postulate that septicemia, a common macroinflammatory occurrence in dialysis patients, contributes to their large burden of cardiovascular disease. Methods. The Dialysis Morbidity and Mortality Wave 2 was a randomly selected prospective cohort of incident dialysis patients. Admission claims data were used to define and calculate rates of septicemia or bacteremia and cardiovascular events in those with Medicare as the primary payer. Utilizing Cox proportional hazard models we determined the association between baseline access and the development of bacteremia or sepsis, and also the association between bacteremia or sepsis episodes and subsequent cardiovascular events. Results. The 2358 (59%) patients with Medicare as primary payer were older and more likely to have heart failure than those with other payers, but had similar comorbidity-adjusted mortality hazards. Rates of first septicemia, bacteremia, or either condition, were 7.0, 5.9 and 10.4 events per 100-patient years, respectively. Cox regression identified initial dialysis access as the main antecedent of septicemia or bacteremia. Hazards ratios for hemodialysis with permanent catheters, temporary catheters, and grafts were 1.95 (95% CI 1.47-2.57), 1.76 (95% CI 1.29-2.41), and 1.05 (95% CI 0.82-1.35), respectively, while that for peritoneal dialysis was 0.96 (95% CI 0.75-1.23) (reference arteriovenous fistula). After adjustment for baseline factors, septicemia or bacteremia, as a time-dependent covariate, was associated with subsequent death [hazards ratio (HR) 2.33, 95% CI 1.38-2.28], myocardial infarction (HR 1.78, 95% CI 1.38-2.28), heart failure (HR 1.64, 95% CI 1.39-1.95), peripheral vascular disease (HR 1.64, 95% CI 1.34-2.0), and stroke (HR 2.04, 95% CI 1.27-3.28). Conclusion. Septicemia appears to be an important, potentially preventable, cardiovascular risk factor in dialysis patients. JF - Kidney International AU - Ishani, Areef AU - Collins, Allan J AU - Herzog, Charles A AU - Foley, Robert N AD - Areef Ishani, Division of Nephrology (111J), Department of Medicine, Veterans Affairs Medical Center, One Veterans Drive, Minneapolis, MN 55417, areef.ishani@med.va.gov Y1 - 2005/07// PY - 2005 DA - Jul 2005 SP - 311 EP - 318 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 68 IS - 1 SN - 0085-2538, 0085-2538 KW - Microbiology Abstracts B: Bacteriology KW - Mortality KW - Data processing KW - Septicemia KW - Peritoneum KW - Stroke KW - Bacteremia KW - Hemodialysis KW - Vascular diseases KW - Morbidity KW - Myocardial infarction KW - Models KW - Sepsis KW - Risk factors KW - Kidney KW - Catheters KW - Waves KW - Cardiovascular diseases KW - Heart diseases KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19286838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+International&rft.atitle=Septicemia%2C+access+and+cardiovascular+disease+in+dialysis+patients%3A+The+USRDS+Wave+2+Study&rft.au=Ishani%2C+Areef%3BCollins%2C+Allan+J%3BHerzog%2C+Charles+A%3BFoley%2C+Robert+N&rft.aulast=Ishani&rft.aufirst=Areef&rft.date=2005-07-01&rft.volume=68&rft.issue=1&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Kidney+International&rft.issn=00852538&rft_id=info:doi/10.1111%2Fj.1523-1755.2005.00414.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - SuppNotes - Figures, 3; tables, 4; formulas, 11; references, 49. N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; Septicemia; Stroke; Peritoneum; Bacteremia; Vascular diseases; Hemodialysis; Myocardial infarction; Morbidity; Models; Sepsis; Risk factors; Catheters; Kidney; Waves; Cardiovascular diseases; Heart diseases DO - http://dx.doi.org/10.1111/j.1523-1755.2005.00414.x ER - TY - JOUR T1 - Cochlear function in mice following inhalation of brevetoxin-3 AN - 17661155; 6525056 AB - Brevetoxin-3 was shown previously to adversely affect central auditory function in goldfish. The present study evaluated the effects of exposure to this agent on cochlear function in mice using the 2f sub(1)-f sub(2) distortion-product otoacoustic emission (DPOAE). Towards this end, inbred CBA/CaJ mice were exposed to a relatively high concentration of brevetoxin-3 ( similar to 400 mu g/m super(3)) by nose-only inhalation for a 2-h period. Further, a subset of these mice received a second exposure a day later that lasted for an additional 4 h. Mice exposed only once for 2 h did not exhibit any notable cochlear effects. Similarly, mice exposed two times, for a cumulative dose of 6 h, exhibited essentially no change in DPOAE levels. JF - Journal of Comparative Physiology, A AU - Benson, J M AU - Stagner, B B AU - Martin, G K AU - Friedman, M AU - Durr, SE AU - Gomez, A AU - McDonald, J AU - Fleming, LE AU - Backer, L C AU - Baden, D G AU - Bourdelais, A AU - Naar, J AU - Lonsbury-Martin, B L AD - Department of Otolaryngology, University of Colorado Health Sciences Center, Denver, CO, USA, glen.martin2@med.va.gov Y1 - 2005/07// PY - 2005 DA - Jul 2005 SP - 619 EP - 626 VL - 191 IS - 7 SN - 0340-7594, 0340-7594 KW - brevetoxin 3 KW - brevetoxin-3 KW - dose-response effects KW - mice KW - Animal Behavior Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Y 25697:Mammals (excluding primates) KW - X 24172:Plants KW - N3 11016:Auditory and vestibular systems (including echolocation) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17661155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Comparative+Physiology%2C+A&rft.atitle=Cochlear+function+in+mice+following+inhalation+of+brevetoxin-3&rft.au=Benson%2C+J+M%3BStagner%2C+B+B%3BMartin%2C+G+K%3BFriedman%2C+M%3BDurr%2C+SE%3BGomez%2C+A%3BMcDonald%2C+J%3BFleming%2C+LE%3BBacker%2C+L+C%3BBaden%2C+D+G%3BBourdelais%2C+A%3BNaar%2C+J%3BLonsbury-Martin%2C+B+L&rft.aulast=Benson&rft.aufirst=J&rft.date=2005-07-01&rft.volume=191&rft.issue=7&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Journal+of+Comparative+Physiology%2C+A&rft.issn=03407594&rft_id=info:doi/10.1007%2Fs00359-005-0613-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-12-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1007/s00359-005-0613-0 ER - TY - CPAPER T1 - Optimizing Informatics Support for Collaborative Care: Examples from Veterans Administration Smoking and Depression Treatment Programs T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39724447; 3959284 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Chaney, Edmund AU - Bonner, Laura AU - Vivell, Susan AU - Austin, Colletta AU - Sherman, Scott Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Mental disorders KW - Depression KW - Smoking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39724447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Optimizing+Informatics+Support+for+Collaborative+Care%3A+Examples+from+Veterans+Administration+Smoking+and+Depression+Treatment+Programs&rft.au=Chaney%2C+Edmund%3BBonner%2C+Laura%3BVivell%2C+Susan%3BAustin%2C+Colletta%3BSherman%2C+Scott&rft.aulast=Chaney&rft.aufirst=Edmund&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hospital Market Effects on Uptake and Utilization of Innovative Healthcare Technologies: 1983-2001 T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39686570; 3958772 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Groeneveld, Peter AU - Kruse, Gregory AU - Brookstein, Ellen K AU - Zhu, Jingsan AU - Chen, Zhen AU - Volpp, Kevin G M Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Hospitals KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39686570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Hospital+Market+Effects+on+Uptake+and+Utilization+of+Innovative+Healthcare+Technologies%3A+1983-2001&rft.au=Groeneveld%2C+Peter%3BKruse%2C+Gregory%3BBrookstein%2C+Ellen+K%3BZhu%2C+Jingsan%3BChen%2C+Zhen%3BVolpp%2C+Kevin+G+M&rft.aulast=Groeneveld&rft.aufirst=Peter&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Telemedicine Intervention to Improve Depression Care in Rural CBOCs T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39685477; 3958380 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Fortney, John AU - Pyne, Jeff M AU - Edlund, Mark J AU - Robinson, Dean E AU - Mittal, Dinesh AU - Henderson, Kathy L Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Mental disorders KW - Depression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39685477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Telemedicine+Intervention+to+Improve+Depression+Care+in+Rural+CBOCs&rft.au=Fortney%2C+John%3BPyne%2C+Jeff+M%3BEdlund%2C+Mark+J%3BRobinson%2C+Dean+E%3BMittal%2C+Dinesh%3BHenderson%2C+Kathy+L&rft.aulast=Fortney&rft.aufirst=John&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Qualitative Observations to Inform a Quantitative Survey Design in Human Factors Research T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39684798; 3958763 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Lulejian, Armine AU - Patterson, Emily AU - Saleem, Jason AU - Militello, Laura AU - Asch, Steven Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Human factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39684798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Using+Qualitative+Observations+to+Inform+a+Quantitative+Survey+Design+in+Human+Factors+Research&rft.au=Lulejian%2C+Armine%3BPatterson%2C+Emily%3BSaleem%2C+Jason%3BMilitello%2C+Laura%3BAsch%2C+Steven&rft.aulast=Lulejian&rft.aufirst=Armine&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nursing Factors and Surgical Outcomes in VHA T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39683602; 3959120 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Lowy, Elliott AU - Anne, E AU - Sharp, Nancy AU - Greiner, Gwendolyn AU - Li, Yu Fang Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Nursing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39683602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Nursing+Factors+and+Surgical+Outcomes+in+VHA&rft.au=Lowy%2C+Elliott%3BAnne%2C+E%3BSharp%2C+Nancy%3BGreiner%2C+Gwendolyn%3BLi%2C+Yu+Fang&rft.aulast=Lowy&rft.aufirst=Elliott&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Relationship of Hospital Organizational Culture to Patient Safety Indicators T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39683291; 3959139 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Rivard, Peter AU - Christiansen, Cindy L AU - Zhao, Shibei AU - Loveland, Susan A AU - Rosen, Amy K Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Hospitals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39683291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=The+Relationship+of+Hospital+Organizational+Culture+to+Patient+Safety+Indicators&rft.au=Rivard%2C+Peter%3BChristiansen%2C+Cindy+L%3BZhao%2C+Shibei%3BLoveland%2C+Susan+A%3BRosen%2C+Amy+K&rft.aulast=Rivard&rft.aufirst=Peter&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Weighted versus Dichotomous Thresholds for Diabetes Performance Measurement in Veterans Health Administration (VHA) Facilities T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39683043; 3959077 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Aron, David AU - Pogach, Leonard M AU - Rajan, Mangala Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39683043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Comparison+of+Weighted+versus+Dichotomous+Thresholds+for+Diabetes+Performance+Measurement+in+Veterans+Health+Administration+%28VHA%29+Facilities&rft.au=Aron%2C+David%3BPogach%2C+Leonard+M%3BRajan%2C+Mangala&rft.aulast=Aron&rft.aufirst=David&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Civility among Healthcare Employees: The Impact on Patients T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39677195; 3958876 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Meterko, Mark AU - Mohr, David AU - Charns, Martin AU - Warren, Nicholas AU - Hodgson, Michael Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Personnel KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39677195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Civility+among+Healthcare+Employees%3A+The+Impact+on+Patients&rft.au=Meterko%2C+Mark%3BMohr%2C+David%3BCharns%2C+Martin%3BWarren%2C+Nicholas%3BHodgson%2C+Michael&rft.aulast=Meterko&rft.aufirst=Mark&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nursing Factors and Patient Outcomes in VHA T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39676587; 3959143 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Sales, Anne AU - Sharp, Nancy AU - Greiner, Gwendolyn AU - Li, Yu-Fang AU - Lowy, Elliott Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Nursing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39676587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Nursing+Factors+and+Patient+Outcomes+in+VHA&rft.au=Sales%2C+Anne%3BSharp%2C+Nancy%3BGreiner%2C+Gwendolyn%3BLi%2C+Yu-Fang%3BLowy%2C+Elliott&rft.aulast=Sales&rft.aufirst=Anne&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Quality Olympics: A System-Wide Approach to Improving Diabetes Care T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39676071; 3959078 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Aron, David AU - Ober, Scott AU - Caron, Aleece AU - Davidson, Michelle AU - Aron, David C Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39676071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=The+Quality+Olympics%3A+A+System-Wide+Approach+to+Improving+Diabetes+Care&rft.au=Aron%2C+David%3BOber%2C+Scott%3BCaron%2C+Aleece%3BDavidson%2C+Michelle%3BAron%2C+David+C&rft.aulast=Aron&rft.aufirst=David&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enrollment in Medicare HMO by Elderly Women Veterans T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39663743; 3958739 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Wei, Iris AU - John, Dolly AU - Davila, Jessica AU - Byrne, Margaret AU - Petersen, Laura AU - Osemene, Nora AU - Sundaravaradan, Raji AU - Morgan, Robert Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Elderly KW - Geriatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39663743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Enrollment+in+Medicare+HMO+by+Elderly+Women+Veterans&rft.au=Wei%2C+Iris%3BJohn%2C+Dolly%3BDavila%2C+Jessica%3BByrne%2C+Margaret%3BPetersen%2C+Laura%3BOsemene%2C+Nora%3BSundaravaradan%2C+Raji%3BMorgan%2C+Robert&rft.aulast=Wei&rft.aufirst=Iris&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Searching for Womens Health Centers: Yield of Internet vs. Traditional Telephone Contacts for Identifying Research Sites T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39663565; 3958718 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Bayliss, Nichole AU - Bean-Mayberry, Bevanne AU - Yano, Elizabeth M AU - Navratil, Judith AU - Weisman, Carol S AU - Scholle, Sarah Hudson Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Internet KW - Telephone systems KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39663565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Searching+for+Womens+Health+Centers%3A+Yield+of+Internet+vs.+Traditional+Telephone+Contacts+for+Identifying+Research+Sites&rft.au=Bayliss%2C+Nichole%3BBean-Mayberry%2C+Bevanne%3BYano%2C+Elizabeth+M%3BNavratil%2C+Judith%3BWeisman%2C+Carol+S%3BScholle%2C+Sarah+Hudson&rft.aulast=Bayliss&rft.aufirst=Nichole&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Evaluation of Contextual Factors in Breast and Cervical Cancer Screening T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39662959; 3958591 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Tomolo, Anne AU - Litaker, David AU - Aron, David Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Cervical cancer KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39662959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=An+Evaluation+of+Contextual+Factors+in+Breast+and+Cervical+Cancer+Screening&rft.au=Tomolo%2C+Anne%3BLitaker%2C+David%3BAron%2C+David&rft.aulast=Tomolo&rft.aufirst=Anne&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Medicare+Choice Enrollment and Plan Benefits Among Black, Hispanic and White Medicare Enrolled VA-Using Veterans in CY2000 T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39662882; 3958594 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - John, Dolly A AU - Sundaravaradan, Raji AU - Davila, Jessica AU - Wei, Iris I AU - Byrne, Margaret AU - Petersen, Laura AU - Paterniti, Debora A AU - Osemene, Nora AU - Morgan, Robert O Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Highways KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39662882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Medicare%2BChoice+Enrollment+and+Plan+Benefits+Among+Black%2C+Hispanic+and+White+Medicare+Enrolled+VA-Using+Veterans+in+CY2000&rft.au=John%2C+Dolly+A%3BSundaravaradan%2C+Raji%3BDavila%2C+Jessica%3BWei%2C+Iris+I%3BByrne%2C+Margaret%3BPetersen%2C+Laura%3BPaterniti%2C+Debora+A%3BOsemene%2C+Nora%3BMorgan%2C+Robert+O&rft.aulast=John&rft.aufirst=Dolly&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Timing of Surgical and Adjuvant Therapy for Colorectal Cancer T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39659117; 3958565 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Hynes, Denise AU - Perrin, Ruth A AU - Zhang, Qiuying AU - Koelling, Kristin AU - Sohn, Min-Woong Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Adjuvants KW - Therapy KW - Colorectal cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39659117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Timing+of+Surgical+and+Adjuvant+Therapy+for+Colorectal+Cancer&rft.au=Hynes%2C+Denise%3BPerrin%2C+Ruth+A%3BZhang%2C+Qiuying%3BKoelling%2C+Kristin%3BSohn%2C+Min-Woong&rft.aulast=Hynes&rft.aufirst=Denise&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nurses in VHA Hospitals: Results from the Nurse Staffing and Patient Outcomes in VA Nursing Staff Survey T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39654484; 3959232 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Sharp, Nancy AU - Sales, Anne E AU - Greiner, Gwendolyn T AU - Li, Yu-Fang AU - Mitchell, Pamela AU - Sochalski, Julie Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Nursing KW - Medical personnel KW - Hospitals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39654484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Nurses+in+VHA+Hospitals%3A+Results+from+the+Nurse+Staffing+and+Patient+Outcomes+in+VA+Nursing+Staff+Survey&rft.au=Sharp%2C+Nancy%3BSales%2C+Anne+E%3BGreiner%2C+Gwendolyn+T%3BLi%2C+Yu-Fang%3BMitchell%2C+Pamela%3BSochalski%2C+Julie&rft.aulast=Sharp&rft.aufirst=Nancy&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Provider-Friendly Screening Tool to Identify Patients who Lack Physician Trust T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39653407; 3958671 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Kuykendall, David AU - Kallen, Michael Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39653407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=A+Provider-Friendly+Screening+Tool+to+Identify+Patients+who+Lack+Physician+Trust&rft.au=Kuykendall%2C+David%3BKallen%2C+Michael&rft.aulast=Kuykendall&rft.aufirst=David&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Primary Care Physician Characteristics and Involvement in a Program to Improve Outpatient Clinic Operations T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39653100; 3959373 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Mohr, David AU - Lukas, Carol VanDeusen AU - Meterko, Mark AU - Seibert, Marjorie Nealon Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Financial management KW - Policies KW - Public access KW - Public health KW - Drugs KW - Insurance KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39653100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Primary+Care+Physician+Characteristics+and+Involvement+in+a+Program+to+Improve+Outpatient+Clinic+Operations&rft.au=Mohr%2C+David%3BLukas%2C+Carol+VanDeusen%3BMeterko%2C+Mark%3BSeibert%2C+Marjorie+Nealon&rft.aulast=Mohr&rft.aufirst=David&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Women Veterans Satisfaction with VA Hospitalization T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39651998; 3958724 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Cherrie, Carron AU - Schwartz, Skai AU - Mathias, Leigh AU - Mikelonis, Margaret AU - Lawrie, Toni Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Financial management KW - Policies KW - Public access KW - Public health KW - Drugs KW - Insurance KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39651998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Women+Veterans+Satisfaction+with+VA+Hospitalization&rft.au=Cherrie%2C+Carron%3BSchwartz%2C+Skai%3BMathias%2C+Leigh%3BMikelonis%2C+Margaret%3BLawrie%2C+Toni&rft.aulast=Cherrie&rft.aufirst=Carron&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Educational Attainment and Cancer Mortality, 1959 - 2001: Patterns, Trends, and Pathways T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39651884; 3958697 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Tarlov, Elizabeth AU - Kaestner, Robert AU - Warnecke, Richard Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Mortality KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39651884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Educational+Attainment+and+Cancer+Mortality%2C+1959+-+2001%3A+Patterns%2C+Trends%2C+and+Pathways&rft.au=Tarlov%2C+Elizabeth%3BKaestner%2C+Robert%3BWarnecke%2C+Richard&rft.aulast=Tarlov&rft.aufirst=Elizabeth&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Physician Attitudes Toward Pay-For-Performance Programs: Development and Validation of a Measurement Instrument T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39650861; 3959125 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Meterko, Mark AU - Young, Gary J AU - White, Bert AU - Burgess, James F AU - Berlowitz, Dan AU - Guldin, Matthew R Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Financial management KW - Policies KW - Public access KW - Public health KW - Drugs KW - Insurance KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39650861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Physician+Attitudes+Toward+Pay-For-Performance+Programs%3A+Development+and+Validation+of+a+Measurement+Instrument&rft.au=Meterko%2C+Mark%3BYoung%2C+Gary+J%3BWhite%2C+Bert%3BBurgess%2C+James+F%3BBerlowitz%2C+Dan%3BGuldin%2C+Matthew+R&rft.aulast=Meterko&rft.aufirst=Mark&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Depression and At-Risk Alcohol use Outcomes for Older Primary Care Patients in Integrated Care and Enhanced Specialty Referral T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39647538; 3959296 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Krahn, Dean AU - Bartels, Steve AU - Coakley, Eugenie AU - Oslin, David AU - Chung, Henry AU - Levkoff, Sue Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Mental disorders KW - Depression KW - Alcohols KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39647538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Depression+and+At-Risk+Alcohol+use+Outcomes+for+Older+Primary+Care+Patients+in+Integrated+Care+and+Enhanced+Specialty+Referral&rft.au=Krahn%2C+Dean%3BBartels%2C+Steve%3BCoakley%2C+Eugenie%3BOslin%2C+David%3BChung%2C+Henry%3BLevkoff%2C+Sue&rft.aulast=Krahn&rft.aufirst=Dean&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Impact of VA Priority Score on use of Fecal Occult Blood Test in VA and Medicare Systems T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39642166; 3959459 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Schult, Tamara AU - Virnig, Beth AU - Kochevar, Laura AU - Nelson, Dave AU - Bershadsky, Boris Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Blood KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39642166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=The+Impact+of+VA+Priority+Score+on+use+of+Fecal+Occult+Blood+Test+in+VA+and+Medicare+Systems&rft.au=Schult%2C+Tamara%3BVirnig%2C+Beth%3BKochevar%2C+Laura%3BNelson%2C+Dave%3BBershadsky%2C+Boris&rft.aulast=Schult&rft.aufirst=Tamara&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Survey of Nursing Work Environment: A Confirmatory Factor Analysis of the Nursing Work Index-Revised T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39639956; 3959220 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Li, Yu-Fang AU - Sales, Anne AU - Sharp, Nancy AU - Greiner, Gwen AU - Lowy, Elliott Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Environmental factors KW - Nursing KW - Factor analysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39639956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Survey+of+Nursing+Work+Environment%3A+A+Confirmatory+Factor+Analysis+of+the+Nursing+Work+Index-Revised&rft.au=Li%2C+Yu-Fang%3BSales%2C+Anne%3BSharp%2C+Nancy%3BGreiner%2C+Gwen%3BLowy%2C+Elliott&rft.aulast=Li&rft.aufirst=Yu-Fang&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Management Support in Implementing Innovative Clinical Practices T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39612746; 3958878 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Lukas, Carol VanDeusen AU - Meterko, Mark AU - Mohr, David AU - Seibert, Marjorie Nealon Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Financial management KW - Policies KW - Public access KW - Public health KW - Drugs KW - Insurance KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=The+Role+of+Management+Support+in+Implementing+Innovative+Clinical+Practices&rft.au=Lukas%2C+Carol+VanDeusen%3BMeterko%2C+Mark%3BMohr%2C+David%3BSeibert%2C+Marjorie+Nealon&rft.aulast=Lukas&rft.aufirst=Carol&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Outcomes of the Assisted Living Pilot Program T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39612608; 3958845 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Hedrick, Susan AU - Guihan, Marylou AU - Chapko, Michael AU - Manheim, Larry AU - Sullivan, Jean AU - Tornatore, Jane Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Financial management KW - Policies KW - Public access KW - Public health KW - Drugs KW - Insurance KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Outcomes+of+the+Assisted+Living+Pilot+Program&rft.au=Hedrick%2C+Susan%3BGuihan%2C+Marylou%3BChapko%2C+Michael%3BManheim%2C+Larry%3BSullivan%2C+Jean%3BTornatore%2C+Jane&rft.aulast=Hedrick&rft.aufirst=Susan&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of a Medication Copayment Increase on Medication Acquisition in the VA T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39612386; 3958798 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Stroupe, Kevin AU - Smith, Bridget AU - Lee, Todd AU - Durazo-Arvizu, Ramon AU - Tarlov, Elizabeth AU - Cao, Lishan Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Financial management KW - Policies KW - Public access KW - Public health KW - Drugs KW - Insurance KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Impact+of+a+Medication+Copayment+Increase+on+Medication+Acquisition+in+the+VA&rft.au=Stroupe%2C+Kevin%3BSmith%2C+Bridget%3BLee%2C+Todd%3BDurazo-Arvizu%2C+Ramon%3BTarlov%2C+Elizabeth%3BCao%2C+Lishan&rft.aulast=Stroupe&rft.aufirst=Kevin&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Liver Health Initiative: Coordinating Hepatitis Prevention and Treatment Referral through a Substance use Disorders Clinic T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39604497; 3958397 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Hagedorn, Hildi AU - Willenbring, Mark AU - Dieperink, Eric AU - Ho, Samuel AU - Pexa, Nancy AU - Dingmann, Debra Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Prevention KW - Liver KW - Hepatitis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39604497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=The+Liver+Health+Initiative%3A+Coordinating+Hepatitis+Prevention+and+Treatment+Referral+through+a+Substance+use+Disorders+Clinic&rft.au=Hagedorn%2C+Hildi%3BWillenbring%2C+Mark%3BDieperink%2C+Eric%3BHo%2C+Samuel%3BPexa%2C+Nancy%3BDingmann%2C+Debra&rft.aulast=Hagedorn&rft.aufirst=Hildi&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Racial Differences in Attitudes toward Innovative Medical Technology T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39601658; 3958659 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Groeneveld, Peter AU - Sonnad, Seema S AU - Lee, Anee K AU - Asch, David A AU - Shea, Judy A Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Financial management KW - Policies KW - Public access KW - Public health KW - Drugs KW - Insurance KW - Sex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39601658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Racial+Differences+in+Attitudes+toward+Innovative+Medical+Technology&rft.au=Groeneveld%2C+Peter%3BSonnad%2C+Seema+S%3BLee%2C+Anee+K%3BAsch%2C+David+A%3BShea%2C+Judy+A&rft.aulast=Groeneveld&rft.aufirst=Peter&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Influence of Organizational Culture on Physician and Nurse Resignation Rates T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39598198; 3959203 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Mohr, David AU - Meterko, Mark AU - Young, Gary AU - Charns, Martin Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Nursing KW - Medical personnel KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39598198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=The+Influence+of+Organizational+Culture+on+Physician+and+Nurse+Resignation+Rates&rft.au=Mohr%2C+David%3BMeterko%2C+Mark%3BYoung%2C+Gary%3BCharns%2C+Martin&rft.aulast=Mohr&rft.aufirst=David&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of a Patient-Centered Care Coordination/Home-Telehealth Disease Management Program for Veterans with Diabetes T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39568697; 3958492 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Chumbler, Neale AU - Vogel, W Bruce AU - Garel, Mischka AU - Qin, Haijing AU - Kobb, Rita AU - Ryan, Patricia Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39568697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Evaluation+of+a+Patient-Centered+Care+Coordination%2FHome-Telehealth+Disease+Management+Program+for+Veterans+with+Diabetes&rft.au=Chumbler%2C+Neale%3BVogel%2C+W+Bruce%3BGarel%2C+Mischka%3BQin%2C+Haijing%3BKobb%2C+Rita%3BRyan%2C+Patricia&rft.aulast=Chumbler&rft.aufirst=Neale&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Organizational Attributes Important in Leaders' Efforts to Transform Health Care T2 - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AN - 39563070; 3958890 JF - 2005 Annual Research Meeting of the AcademyHealth (ARM 2005) AU - Cramer, Irene E AU - Shwartz, Michael AU - Holmes, Sally K AU - Restuccia, Joseph AU - Cohen, Alan B AU - Lukas, Carol VanDeusen AU - Sullivan, Jenny AU - Meterko, Mark AU - Charns, Martin P Y1 - 2005/06/26/ PY - 2005 DA - 2005 Jun 26 KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39563070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.atitle=Organizational+Attributes+Important+in+Leaders%27+Efforts+to+Transform+Health+Care&rft.au=Cramer%2C+Irene+E%3BShwartz%2C+Michael%3BHolmes%2C+Sally+K%3BRestuccia%2C+Joseph%3BCohen%2C+Alan+B%3BLukas%2C+Carol+VanDeusen%3BSullivan%2C+Jenny%3BMeterko%2C+Mark%3BCharns%2C+Martin+P&rft.aulast=Cramer&rft.aufirst=Irene&rft.date=2005-06-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Research+Meeting+of+the+AcademyHealth+%28ARM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/2005/abstracts.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. AN - 67934941; 15955935 AB - To determine the relative tolerability and efficacy of two newer antiepileptic drugs, lamotrigine (LTG) and gabapentin (GBP), as compared to carbamazepine (CBZ) in older patients with epilepsy. This was an 18-center, randomized, double-blind, double dummy, parallel study of 593 elderly subjects with newly diagnosed seizures. Patients were randomly assigned to one of three treatment groups: GBP 1,500 mg/day, LTG 150 mg/day, CBZ 600 mg/day. The primary outcome measure was retention in trial for 12 months. Mean age was 72 years. The most common etiology was cerebral infarction. Patients had multiple medical conditions and took an average of seven comedications. Mean plasma levels at 6 weeks were as follows: GBP 8.67 +/- 4.83 microg/mL, LTG 2.87 +/- 1.60 microg/mL, CBZ 6.79 +/- 2.92 microg/mL. They remained stable throughout the trial. Early terminations: LTG 44.2%, GBP 51%, CBZ 64.5% (p = 0.0002). Significant paired comparisons: LTG vs CBZ: p < 0.0001; GBP vs CBZ: p = 0.008. Terminations for adverse events: LTG 12.1%, GBP 21.6%, CBZ 31% (p = 0.001). Significant paired comparisons: LTG vs CBZ: p < 0.0001; LTG vs GBP: p = 0.015. There were no significant differences in seizure free rate at 12 months. The main limiting factor in patient retention was adverse drug reactions. Patients taking lamotrigine (LTG) or gabapentin (GBP) did better than those taking carbamazepine. Seizure control was similar among groups. LTG and GBP should be considered as initial therapy for older patients with newly diagnosed seizures. JF - Neurology AU - Rowan, A J AU - Ramsay, R E AU - Collins, J F AU - Pryor, F AU - Boardman, K D AU - Uthman, B M AU - Spitz, M AU - Frederick, T AU - Towne, A AU - Carter, G S AU - Marks, W AU - Felicetta, J AU - Tomyanovich, M L AU - VA Cooperative Study 428 Group AD - VA Medical Center, Bronx, NY 10468, USA. aj.rowan@med.va.gov ; VA Cooperative Study 428 Group Y1 - 2005/06/14/ PY - 2005 DA - 2005 Jun 14 SP - 1868 EP - 1873 VL - 64 IS - 11 KW - Amines KW - 0 KW - Anticonvulsants KW - Cyclohexanecarboxylic Acids KW - Triazines KW - Carbamazepine KW - 33CM23913M KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - gabapentin KW - 6CW7F3G59X KW - lamotrigine KW - U3H27498KS KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Patient Compliance -- statistics & numerical data KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Humans KW - Treatment Outcome KW - Aged KW - Patient Selection KW - Hospitals, Veterans -- statistics & numerical data KW - United States Department of Veterans Affairs -- statistics & numerical data KW - Cerebral Infarction -- complications KW - gamma-Aminobutyric Acid -- blood KW - Amines -- administration & dosage KW - Anticonvulsants -- adverse effects KW - Anticonvulsants -- administration & dosage KW - Cyclohexanecarboxylic Acids -- administration & dosage KW - Epilepsy -- drug therapy KW - gamma-Aminobutyric Acid -- adverse effects KW - gamma-Aminobutyric Acid -- administration & dosage KW - Anticonvulsants -- blood KW - Triazines -- blood KW - Aging -- physiology KW - Amines -- blood KW - Carbamazepine -- adverse effects KW - Cyclohexanecarboxylic Acids -- adverse effects KW - Carbamazepine -- blood KW - Carbamazepine -- administration & dosage KW - Cyclohexanecarboxylic Acids -- blood KW - Triazines -- adverse effects KW - Triazines -- administration & dosage KW - Epilepsy -- etiology KW - Epilepsy -- epidemiology KW - Amines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67934941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=New+onset+geriatric+epilepsy%3A+a+randomized+study+of+gabapentin%2C+lamotrigine%2C+and+carbamazepine.&rft.au=Rowan%2C+A+J%3BRamsay%2C+R+E%3BCollins%2C+J+F%3BPryor%2C+F%3BBoardman%2C+K+D%3BUthman%2C+B+M%3BSpitz%2C+M%3BFrederick%2C+T%3BTowne%2C+A%3BCarter%2C+G+S%3BMarks%2C+W%3BFelicetta%2C+J%3BTomyanovich%2C+M+L%3BVA+Cooperative+Study+428+Group&rft.aulast=Rowan&rft.aufirst=A&rft.date=2005-06-14&rft.volume=64&rft.issue=11&rft.spage=1868&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=1526-632X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-27 N1 - Date created - 2005-06-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: ACP J Club. 2006 Jan-Feb;144(1):6 [16388556] Neurology. 2005 Jun 14;64(11):1834-5 [15955930] Epilepsy Curr. 2006 Jan-Feb;6(1):27-9 [16477322] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gulf War veterans' health: medical evaluation of a U.S. cohort. AN - 67910083; 15941694 AB - United States military personnel reported various symptoms after deployment to the Persian Gulf during the 1991 Gulf War. However, the symptoms' long-term prevalence and association with deployment remain controversial. To assess and compare the prevalence of selected medical conditions in a national cohort of deployed and nondeployed Gulf War veterans who were evaluated by direct medical and teledermatologic examinations. A cross-sectional prevalence study performed 10 years after the 1991 Gulf War. Veterans were examined at 1 of 16 Veterans Affairs medical centers. Deployed (n = 1061) and nondeployed (n = 1128) veterans of the 1991 Gulf War. Primary outcome measures included fibromyalgia, the chronic fatigue syndrome, dermatologic conditions, dyspepsia, physical health-related quality of life (Short Form-36 [SF-36]), hypertension, obstructive lung disease, arthralgias, and peripheral neuropathy. Of 12 conditions, only 4 conditions were more prevalent among deployed than nondeployed veterans: fibromyalgia (deployed, 2.0%; nondeployed, 1.2%; odds ratio, 2.32 [95% CI, 1.02 to 5.27]); the chronic fatigue syndrome (deployed, 1.6%; nondeployed 0.1%; odds ratio, 40.6 [CI, 10.2 to 161]); dermatologic conditions (deployed, 34.6%; nondeployed, 26.8%; odds ratio, 1.38 [CI, 1.06 to 1.80]), and dyspepsia (deployed, 9.1%; nondeployed, 6.0%; odds ratio, 1.87 [CI, 1.16 to 2.99]). The mean physical component summary score of the SF-36 for deployed and nondeployed veterans was 49.3 and 50.8, respectively. Relatively low participation rates introduce potential participation bias, and deployment-related illnesses that resolved before the research examination could not, by design, be detected. Ten years after the Gulf War, the physical health of deployed and nondeployed veterans is similar. However, Gulf War deployment is associated with an increased risk for fibromyalgia, the chronic fatigue syndrome, skin conditions, dyspepsia, and a clinically insignificant decrease in the SF-36 physical component score. JF - Annals of internal medicine AU - Eisen, Seth A AU - Kang, Han K AU - Murphy, Frances M AU - Blanchard, Melvin S AU - Reda, Domenic J AU - Henderson, William G AU - Toomey, Rosemary AU - Jackson, Leila W AU - Alpern, Renee AU - Parks, Becky J AU - Klimas, Nancy AU - Hall, Coleen AU - Pak, Hon S AU - Hunter, Joyce AU - Karlinsky, Joel AU - Battistone, Michael J AU - Lyons, Michael J AU - Gulf War Study Participating Investigators AD - Veterans Affairs Medical Center, Washington University School of Medicine, St. Louis, Missouri 63106, USA. seth.eisen@med.va.gov ; Gulf War Study Participating Investigators Y1 - 2005/06/07/ PY - 2005 DA - 2005 Jun 07 SP - 881 EP - 890 VL - 142 IS - 11 KW - Abridged Index Medicus KW - Index Medicus KW - Fibromyalgia -- epidemiology KW - Gulf War KW - Humans KW - Quality of Life KW - Skin Diseases -- epidemiology KW - Warfare KW - Veterans KW - Peripheral Nervous System Diseases -- epidemiology KW - Cross-Sectional Studies KW - Adult KW - Bias (Epidemiology) KW - Dyspepsia -- epidemiology KW - United States -- epidemiology KW - Fatigue Syndrome, Chronic -- epidemiology KW - Female KW - Male KW - Prevalence KW - Persian Gulf Syndrome -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67910083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Gulf+War+veterans%27+health%3A+medical+evaluation+of+a+U.S.+cohort.&rft.au=Eisen%2C+Seth+A%3BKang%2C+Han+K%3BMurphy%2C+Frances+M%3BBlanchard%2C+Melvin+S%3BReda%2C+Domenic+J%3BHenderson%2C+William+G%3BToomey%2C+Rosemary%3BJackson%2C+Leila+W%3BAlpern%2C+Renee%3BParks%2C+Becky+J%3BKlimas%2C+Nancy%3BHall%2C+Coleen%3BPak%2C+Hon+S%3BHunter%2C+Joyce%3BKarlinsky%2C+Joel%3BBattistone%2C+Michael+J%3BLyons%2C+Michael+J%3BGulf+War+Study+Participating+Investigators&rft.aulast=Eisen&rft.aufirst=Seth&rft.date=2005-06-07&rft.volume=142&rft.issue=11&rft.spage=881&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-17 N1 - Date created - 2005-06-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Intern Med. 2005 Jun 7;142(11):938-9 [15941702] Summary For Patients In: Ann Intern Med. 2005 Jun 7;142(11):I22 [15941690] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recognition of Hearing Aid Orientation Content by First-Time Users AN - 85680226; 200701865 AB - Purpose: To examine how well hearing aid orientation (HAO) content is remembered immediately & 1 month after the HAO, & whether the ability to remember this information differs as a function of the audiologist providing the information, patient's age, degree of hearing loss, & prior knowledge of hearing aids. Methods: A convenience sample of 100 older adults completed a multiple-choice test of hearing aid knowledge immediately following the HAO & 1 month later. Covariate & regression analyses were Results: On average, participants recognized 74% of the information immediately following HAO & 78% at 1 month. Hearing loss was associated with declining recognition for hearing aid use & care information immediately following HAO, whereas prior knowledge was associated with successful recognition. Participants who recognized more HAO content immediately also remembered more at 1 month. A difference in recognition of hearing aid information based on audiologist was suggested immediately following HAO, but there were no differences at 1 month. Ability to recognize HAO content was not related to age of participants. Conclusions: On average, participants recognized approximately 75% of the HAO content, which is encouraging from a clinical standpoint, providing support for the efficacy of the HAO & the time audiologists spend in completing it. Moreover, recognition of HAO content improved when tested at 1 month, suggesting audiologists may expect their patients to be aware of a majority of hearing aid use & care information following the hearing aid trial period. Tables, Appendixes, References. Adapted from the source document JF - American Journal of Audiology AU - Reese, Judith L AU - Hnath-Chisolm, Theresa AD - VA Hospital, Tampa, FL judith.reese2@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 94 EP - 104 VL - 14 IS - 1 SN - 1059-0889, 1059-0889 KW - Hearing Therapy (31580) KW - Patients (62950) KW - Audiology (05550) KW - Information Content (35890) KW - Hearing Aids (31250) KW - Practitioner Patient Relationship (66830) KW - article KW - 6811: special education; hearing therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85680226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Audiology&rft.atitle=Recognition+of+Hearing+Aid+Orientation+Content+by+First-Time+Users&rft.au=Reese%2C+Judith+L%3BHnath-Chisolm%2C+Theresa&rft.aulast=Reese&rft.aufirst=Judith&rft.date=2005-06-01&rft.volume=14&rft.issue=1&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Audiology&rft.issn=10590889&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2007-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJALFZ N1 - SubjectsTermNotLitGenreText - Hearing Aids (31250); Information Content (35890); Hearing Therapy (31580); Audiology (05550); Practitioner Patient Relationship (66830); Patients (62950) ER - TY - JOUR T1 - Clinical Guide for Audiologic Tinnitus Management II: Treatment AN - 85662019; 200701861 AB - Purpose: This article is the second of 2 that address the need for basic procedures that can be used commonly by audiologists to manage patients with clinically significant tinnitus, as well as hyperacusis. The method described is termed audiologic tinnitus management (ATM). Method: ATM was developed specifically for use by audiologists. Although certain procedural components were adapted from the methods of tinnitus masking & tinnitus retraining therapy, ATM is uniquely & specifically defined. A detailed description of the ATM assessment procedures is provided in the companion article (J. A. Henry, T. L. Zaugg, & M. A. Schechter, 2005). The present article describes a specific clinical protocol for providing treatment with ATM. Results: The treatment method described for ATM includes structured informational counseling & an individualized program of sound enhancement that can include the use of hearing aids, ear-level noise generators, combination instruments (noise generator & hearing aid combined), personal listening devices (wearable CD, tape, & MP3 players), & augmentative sound devices (e.g., tabletop sound generators). Ongoing treatment appointments involve primarily the structured counseling, evaluation, & adjustment of the use of sound devices, & assessment of treatment outcomes. The informational counseling protocol & an interview form for determining treatment outcomes are each described in step-by-step detail for direct clinical application. Conclusion: This article can serve as a practical clinical guide for audiologists to provide treatment for tinnitus in a uniform manner. Appendixes, References. Adapted from the source document JF - American Journal of Audiology AU - Henry, James A AU - Zaugg, Tara L AU - Schechter, Martin A AD - VA Medical Center, Portland, OR james.henry@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 49 EP - 70 VL - 14 IS - 1 SN - 1059-0889, 1059-0889 KW - Hearing Therapy (31580) KW - Hearing Improvement (31550) KW - Audiology (05550) KW - Hearing Disorders (31450) KW - Communication Aids (13620) KW - article KW - 6811: special education; hearing therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85662019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Audiology&rft.atitle=Clinical+Guide+for+Audiologic+Tinnitus+Management+II%3A+Treatment&rft.au=Henry%2C+James+A%3BZaugg%2C+Tara+L%3BSchechter%2C+Martin+A&rft.aulast=Henry&rft.aufirst=James&rft.date=2005-06-01&rft.volume=14&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Audiology&rft.issn=10590889&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2007-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJALFZ N1 - SubjectsTermNotLitGenreText - Hearing Disorders (31450); Hearing Therapy (31580); Audiology (05550); Communication Aids (13620); Hearing Improvement (31550) ER - TY - JOUR T1 - Clinical guide for audiologic tinnitus management I: Assessment. AN - 85392032; pmid-16180968 AB - This article is the first of 2 that present basic guidelines for audiologists to provide clinical management of tinnitus. The method, termed audiologic tinnitus management (ATM), was developed to incorporate management strategies that can be implemented most efficiently by audiologists.Development of ATM has been drawn from the clinical and research experience of the authors and numerous audiologists. Certain elements of ATM are adapted from the methods of tinnitus masking and tinnitus retraining therapy. Procedures are described in the present article for performing the intake assessment, while the companion article (J. A. Henry, T. L. Zaugg, & M. A. Schechter, 2005) describes treatment methodology.Development of ATM has resulted in defined procedures to conduct a basic tinnitus assessment that includes written questionnaires, an intake interview, audiologic evaluation, and a psychoacoustic assessment of tinnitus perceptual characteristics. If patients report a sound tolerance problem (hyperacusis), loudness discomfort levels are measured at audiometric frequencies. There are special procedures for selecting hearing aids, ear-level noise generators, combination devices (noise generator and hearing aid combined), and personal listening devices (i.e., portable radios and tape, CD, and MP3 players).This article explains each of these assessment components in detail. Adoption of the ATM assessment protocol by audiologists can contribute to the establishment of uniform procedures for the clinical management of tinnitus patients. JF - American journal of audiology AU - Henry, James A AU - Zaugg, Tara L AU - Schechter, Martin A AD - VA Medical Center, Portland, OR 97207, USA. james.henry@med.va.gov Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 21 EP - 48 VL - 14 IS - 1 SN - 1059-0889, 1059-0889 KW - Index Medicus KW - National Library of Medicine KW - Audiology: education KW - Audiometry, Pure-Tone KW - Auditory Threshold KW - Habituation, Psychophysiologic KW - Hearing Aids KW - Humans KW - Hyperacusis: complications KW - Otoscopy KW - Perceptual Masking KW - *Practice Guidelines as Topic KW - Psychoacoustics KW - Questionnaires KW - Referral and Consultation KW - Tinnitus: complications KW - *Tinnitus: diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85392032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+audiology&rft.atitle=Clinical+guide+for+audiologic+tinnitus+management+I%3A+Assessment.&rft.au=Henry%2C+James+A%3BZaugg%2C+Tara+L%3BSchechter%2C+Martin+A&rft.aulast=Henry&rft.aufirst=James&rft.date=2005-06-01&rft.volume=14&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=American+journal+of+audiology&rft.issn=10590889&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The 500 Hz masking-level difference and word recognition in multitalker babble for 40- to 89-year-old listeners with symmetrical sensorineural hearing loss. AN - 85387686; pmid-16178408 AB - The purpose of this study was to determine if performances on a 500 Hz MLD task and a word-recognition task in multitalker babble covaried or varied independently for listeners with normal hearing and for listeners with hearing loss. Young listeners with normal hearing (n = 25) and older listeners (25 per decade from 40-80 years, n = 125) with sensorineural hearing loss were studied. Thresholds at 500 and 1000 Hz were < or = 30 dB HL and < or = 40 dB HL, respectively, with thresholds above 1000 Hz < 100 dB HL. There was no systematic relationship between the 500 Hz MLD and word-recognition performance in multitalker babble. Higher SoNo and SpiNo thresholds were observed for the older listeners, but the MLDs were the same for all groups. Word recognition in babble in terms of signal-to-babble ratio was on average 6.5 (40- to 49-year-old group) to 10.8 dB (80- to 89-year-old group) poorer for the older listeners with hearing loss. Neither pure-tone thresholds nor word-recognition abilities in quiet accurately predicted word-recognition performance in multitalker babble. JF - Journal of the American Academy of Audiology AU - Wilson, Richard H AU - Weakley, Deborah G AD - James H. Quillen VA Medical Center, Mountain Home, Tennessee 37684, USA. RICHARD.WILSON2@MED.VA.GOV Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 367 EP - 382 VL - 16 IS - 6 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Acoustic Stimulation: instrumentation KW - Adult KW - Aged KW - Aged, 80 and over KW - Audiometry, Pure-Tone: instrumentation KW - Auditory Threshold: physiology KW - Differential Threshold: physiology KW - Equipment Design KW - *Hearing Loss, Sensorineural: diagnosis KW - *Hearing Loss, Sensorineural: physiopathology KW - Humans KW - Middle Aged KW - Perceptual Masking: physiology KW - *Recognition (Psychology) KW - *Speech Perception KW - *Verbal Behavior KW - *Vocabulary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85387686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=The+500+Hz+masking-level+difference+and+word+recognition+in+multitalker+babble+for+40-+to+89-year-old+listeners+with+symmetrical+sensorineural+hearing+loss.&rft.au=Wilson%2C+Richard+H%3BWeakley%2C+Deborah+G&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2005-06-01&rft.volume=16&rft.issue=6&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: J Am Acad Audiol. 2005 Jun;16(6):332[16178404] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - A qualitative analysis of inaccurate responses on the Hooper Visual Organization Test. AN - 85385729; pmid-16060429 AB - The present study investigated the types of inaccurate responses, i.e., Don't Know, Semantic, Visual (nonlinguistic), Phonological, Circumlocutory, and Perseverative, made on the Hooper Visual Organization Test by a heterogeneous sample of 68 brain-damaged and 63 substance abuse patients. The mean age of the brain-damaged and substance abuse groups were 46.0 (SD=13.5) and 43.7 (SD=12.9) yr., respectively. Analysis showed that the brain-damaged group made significantly more visual and perseverative responses than the substance abuse group. There was significantly more variance in the Visual responses than the Semantic responses for the brain-damaged group. The authors conclude that visuospatial ability is the primary factor for successful performance on this test. JF - Perceptual and motor skills AU - Lopez, Michael N AU - Lazar, Michael D AU - Imperio, Sherwin M AD - Department of Veterans Affairs Healthcare System, Long Beach, California 90822, USA. michael.lopez@med.va.gov Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 695 EP - 702 VL - 100 IS - 3 Pt 1 SN - 0031-5125, 0031-5125 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Agnosia: diagnosis KW - Agnosia: psychology KW - *Brain Damage, Chronic: diagnosis KW - Brain Damage, Chronic: psychology KW - *Cognition Disorders: diagnosis KW - Cognition Disorders: psychology KW - Humans KW - Middle Aged KW - *Neuropsychological Tests: statistics & numerical data KW - Perceptual Closure KW - Psychometrics KW - Reproducibility of Results KW - Semantics KW - Space Perception KW - *Substance-Related Disorders: diagnosis KW - Substance-Related Disorders: psychology KW - Verbal Behavior KW - *Visual Perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85385729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+motor+skills&rft.atitle=A+qualitative+analysis+of+inaccurate+responses+on+the+Hooper+Visual+Organization+Test.&rft.au=Lopez%2C+Michael+N%3BLazar%2C+Michael+D%3BImperio%2C+Sherwin+M&rft.aulast=Lopez&rft.aufirst=Michael&rft.date=2005-06-01&rft.volume=100&rft.issue=3+Pt+1&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+motor+skills&rft.issn=00315125&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Transient-evoked stimulus-frequency and distortion-product otoacoustic emissions in normal and impaired ears. AN - 85381296; pmid-16018483 AB - Transient-evoked stimulus-frequency otoacoustic emissions (SFOAEs), recorded using a nonlinear differential technique, and distortion-product otoacoustic emissions (DPOAEs) were measured in 17 normal-hearing and 10 hearing-impaired subjects using pairs of tone pips (pp), gated tones (gg), and for DPOAEs, continuous and gated tones (cg). Temporal envelopes of stimulus and OAE waveforms were obtained by narrow-band filtering at the stimulus or DP frequency. Mean SFOAE latencies in normal ears at 2.7 and 4.0 kHz decreased with increasing stimulus level and were larger at 4.0 kHz than latencies in impaired ears. Equivalent auditory filter bandwidths were calculated as a function of stimulus level from SFOAE latencies by assuming that cochlear transmission is minimum phase. DPOAE latencies varied less with level than SFOAE latencies. The ppDPOAEs often had two (or more) peaks separated in time with latencies consistent with model predictions for distortion and reflection components. Changes in ppDPOAE latency with level were sometimes explained by a shift in relative amplitudes of distortion and reflection components. The pp SFOAE SPL within the main spectral lobe of the pip stimulus was higher for normal ears in the higher-frequency half of the pip than the lower-frequency half, which is likely an effect of basilar membrane two-tone suppression. JF - The Journal of the Acoustical Society of America AU - Konrad-Martin, Dawn AU - Keefe, Douglas H AD - VA RR&D National Center For Rehabilitative Auditory Research, Portland VA Medical Center, Portland, Oregon 97239, USA. dawn.martin@med.va.gov Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 3799 EP - 3815 VL - 117 IS - 6 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Auditory Threshold: physiology KW - Female KW - *Hearing Disorders: diagnosis KW - Hearing Disorders: physiopathology KW - Humans KW - Loudness Perception: physiology KW - Male KW - *Otoacoustic Emissions, Spontaneous: physiology KW - Pitch Discrimination: physiology KW - Reaction Time: physiology KW - Reference Values KW - Sound Spectrography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85381296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Transient-evoked+stimulus-frequency+and+distortion-product+otoacoustic+emissions+in+normal+and+impaired+ears.&rft.au=Konrad-Martin%2C+Dawn%3BKeefe%2C+Douglas+H&rft.aulast=Konrad-Martin&rft.aufirst=Dawn&rft.date=2005-06-01&rft.volume=117&rft.issue=6&rft.spage=3799&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Innovation and Independence: Recent Advances in the Treatment of Paralysis AN - 85334411; llba-200513335 AB - Recent advances in neurobiology & computer technology have resulted in a number of innovations in the treatment of patients with paralysis. In this article, we provide an overview of two techniques under current investigation: (1) injection of chemicals to repair individual nerve fibers & (2) implantation of brain-machine interfaces to record, decode, & replicate individual neural signals. For readers who wish to learn more about respective human clinical trials, contact information is provided. 6 References. Adapted from the source document JF - Journal of Medical Speech-Language Pathology AU - Ross, Katherine B AD - Audiology & Speech Pathology Dept, Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ Katherine.ross3@med.va.gov Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - xxxix EP - xl VL - 13 IS - 2 SN - 1065-1438, 1065-1438 KW - *Nervous System Disorders (57100) KW - *Surgery (85900) KW - *Human Computer Communication (32790) KW - *Research Subjects (72970) KW - *Therapy (89500) KW - *Brain (09350) KW - article KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85334411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Speech-Language+Pathology&rft.atitle=Innovation+and+Independence%3A+Recent+Advances+in+the+Treatment+of+Paralysis&rft.au=Ross%2C+Katherine+B&rft.aulast=Ross&rft.aufirst=Katherine&rft.date=2005-06-01&rft.volume=13&rft.issue=2&rft.spage=xxxix&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Speech-Language+Pathology&rft.issn=10651438&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2005-12-01 N1 - Last updated - 2014-06-17 N1 - CODEN - JSLPEP N1 - SubjectsTermNotLitGenreText - *Nervous System Disorders (57100); *Brain (09350); *Research Subjects (72970); *Human Computer Communication (32790); *Therapy (89500); *Surgery (85900) ER - TY - JOUR T1 - A placebo controlled, double-blind study of mecamylamine treatment for cocaine dependence in patients enrolled in an opiate replacement program. AN - 70159474; 16687365 AB - A placebo controlled, double-blind trial of mecamylamine treatment of cocaine dependence was performed in methadone or LAAM maintained subjects who met DSM-IV criteria for cocaine dependence. After an eight-week placebo run-in screening period, 35 subjects were randomly assigned to receive either mecamylamine (6 mg/day) or placebo transdermal patches for a 16-week treatment period. Outcome measures included quantitative urine benzoylecognine (BE) levels, self-report of cocaine use, cocaine craving, global impression scores, mood, retention, and safety. Mecamylamine was well tolerated, and study retention did not differ by treatment group. Evidence for cocaine use, based on urine BE levels and cocaine abstinence rates, did not differ by treatment group. Self reported cocaine use, cocaine craving, and global impression scores showed moderate improvement in both groups, with a significantly greater reduction in cocaine craving (p < 0.05) and self-rated severity of cocaine dependence (p < 0.05) in the placebo group. This pilot study does not support the effectiveness of mecamylamine for the treatment of cocaine dependence in methadone or LAAM maintained patients. JF - Substance abuse AU - Reid, Malcolm S AU - Angrist, Burt AU - Baker, Sherryl A AU - O'leary, Siobhan AU - Stone, Jennifer AU - Schwartz, Marion AU - Leiderman, Deborah AU - Montgomery, Ann AU - Elkashef, Ahmed AU - Majewska, Dorota AU - Robinson, James AU - Rotrosen, John AD - New York University School of Medicine, New York, NY 10010, USA. malcolm.reid@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 5 EP - 14 VL - 26 IS - 2 SN - 0889-7077, 0889-7077 KW - Narcotics KW - 0 KW - Nicotinic Antagonists KW - benzoylecgonine KW - 5353I8I6YS KW - Mecamylamine KW - 6EE945D3OK KW - Cocaine KW - I5Y540LHVR KW - Methadyl Acetate KW - L59OC40KWJ KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - New York City KW - Administration, Cutaneous KW - Cocaine -- analogs & derivatives KW - Double-Blind Method KW - Cocaine -- urine KW - Humans KW - Methadyl Acetate -- administration & dosage KW - Treatment Outcome KW - Narcotics -- administration & dosage KW - Methadone -- administration & dosage KW - Drug Evaluation, Preclinical KW - Male KW - Female KW - Nicotinic Antagonists -- administration & dosage KW - Mecamylamine -- administration & dosage KW - Urban Population KW - Nicotinic Antagonists -- adverse effects KW - Cocaine-Related Disorders -- rehabilitation KW - Mecamylamine -- adverse effects KW - Cocaine-Related Disorders -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70159474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse&rft.atitle=A+placebo+controlled%2C+double-blind+study+of+mecamylamine+treatment+for+cocaine+dependence+in+patients+enrolled+in+an+opiate+replacement+program.&rft.au=Reid%2C+Malcolm+S%3BAngrist%2C+Burt%3BBaker%2C+Sherryl+A%3BO%27leary%2C+Siobhan%3BStone%2C+Jennifer%3BSchwartz%2C+Marion%3BLeiderman%2C+Deborah%3BMontgomery%2C+Ann%3BElkashef%2C+Ahmed%3BMajewska%2C+Dorota%3BRobinson%2C+James%3BRotrosen%2C+John&rft.aulast=Reid&rft.aufirst=Malcolm&rft.date=2005-06-01&rft.volume=26&rft.issue=2&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Substance+abuse&rft.issn=08897077&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-17 N1 - Date created - 2006-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Deployment stressors, gender, and mental health outcomes among Gulf War I veterans. AN - 68784754; 16281224 AB - Findings indicate that war-zone exposure has negative implications for the postdeployment adjustment of veterans; however, most studies have relied on limited conceptualizations of war-zone exposure and focused on male samples. In this study, an array of deployment stressors that were content valid for both female and male Gulf War I military personnel was examined to elucidate gender differences in war-zone exposure and identify gender-based differential associations between stressors and mental health outcomes. While women and men were exposed to both mission-related and interpersonal stressors and both stressor categories were associated with mental health outcomes, women reported more interpersonal stressors and these stressors generally had a stronger impact on women's than on men's mental health. Exceptions are described, and implications are discussed. JF - Journal of traumatic stress AU - Vogt, Dawne S AU - Pless, Anica P AU - King, Lynda A AU - King, Daniel W AD - Women's Health Sciences Division, National Center for PTSD, VA Boston Healthcare System, Boston, Massachusetts 02130, USA. Dawne.Vogt@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 272 EP - 284 VL - 18 IS - 3 SN - 0894-9867, 0894-9867 KW - Index Medicus KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Regression Analysis KW - Sex Factors KW - Stress Disorders, Post-Traumatic -- psychology KW - Anxiety Disorders -- psychology KW - Depressive Disorder -- psychology KW - Humans KW - Interpersonal Relations KW - Sexual Harassment KW - Depressive Disorder -- epidemiology KW - Health Surveys KW - Social Support KW - Anxiety Disorders -- epidemiology KW - United States -- epidemiology KW - Female KW - Male KW - Stress, Psychological -- etiology KW - Gulf War KW - Veterans -- psychology KW - Occupational Exposure -- adverse effects KW - Mental Health KW - Stress, Psychological -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68784754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+traumatic+stress&rft.atitle=Deployment+stressors%2C+gender%2C+and+mental+health+outcomes+among+Gulf+War+I+veterans.&rft.au=Vogt%2C+Dawne+S%3BPless%2C+Anica+P%3BKing%2C+Lynda+A%3BKing%2C+Daniel+W&rft.aulast=Vogt&rft.aufirst=Dawne&rft.date=2005-06-01&rft.volume=18&rft.issue=3&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Journal+of+traumatic+stress&rft.issn=08949867&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-06 N1 - Date created - 2005-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Therapeutic targets for the prevention of type 1 diabetes mellitus. AN - 68466746; 16089357 AB - The pathogenesis of type 1 diabetes is multifactorial, involving genetic susceptibility, autoimmune mechanisms, and environmental factors. This article will focus on two main strategies for altering the underlying disease process in type 1 diabetes. The first strategy is to identify individuals at risk for the development of diabetes and to halt the immune process before it leads to overt clinical disease, Promising in vitro and animal studies with nicotinamide, parenteral insulin, and oral insulin led to large clinical prevention studies, such as the European Nicotinamide Diabetes Intervention Trial and the Diabetes Prevention Trial (DPT-1). These studies failed to show that nicotinamide and insulin prevented the disease in at risk relatives of patients with type 1 diabetes and left many questions unanswered. The second strategy focuses on intervention shortly after diagnosis in order to arrest the destruction of beta cells and to preserve residual beta-cell function as long as possible. Cyclosporin was an effective immunosuppressive but was rejected as a potential treatment for type 1 diabetes because of its renal toxicity. Recently, more attention has been focused on an anti-CD3 antibody, on DiaPep277, and on glutamic acid decarboxylase (GAD). Animal studies and small short-term human trials with these compounds have suggested that they may be effective interventions in patients recently diagnosed with type 1 diabetes. JF - Current drug targets. Immune, endocrine and metabolic disorders AU - Singh, N AU - Palmer, J P AD - Department of Medicine, Division of Endocrinology and Metabolism, Veterans Affairs Puget Sound Healthcare System, Seattle, Washington 98108, USA. Nalini.Singh2@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 227 EP - 236 VL - 5 IS - 2 SN - 1568-0088, 1568-0088 KW - Hypoglycemic Agents KW - 0 KW - Insulin KW - Index Medicus KW - Animals KW - Insulin -- physiology KW - Humans KW - Insulin -- therapeutic use KW - Hypoglycemic Agents -- therapeutic use KW - Diabetes Mellitus, Type 1 -- prevention & control KW - Diabetes Mellitus, Type 1 -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68466746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+targets.+Immune%2C+endocrine+and+metabolic+disorders&rft.atitle=Therapeutic+targets+for+the+prevention+of+type+1+diabetes+mellitus.&rft.au=Singh%2C+N%3BPalmer%2C+J+P&rft.aulast=Singh&rft.aufirst=N&rft.date=2005-06-01&rft.volume=5&rft.issue=2&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Current+drug+targets.+Immune%2C+endocrine+and+metabolic+disorders&rft.issn=15680088&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-23 N1 - Date created - 2005-08-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gonadotrophin-releasing hormone agonist treatment of aggression in Alzheimer's disease: a case report. AN - 68085587; 16050439 AB - No medication has received regulatory approval in the U.S.A. for the distressing agitation and aggressive behaviors that often complicate dementia. Although studies suggest that several psychotropic medications are sometimes useful for these behavioral problems, response is variable and adverse effects often limit treatment. Theoretical considerations suggest that increasing estrogenic activity or reducing androgenic activity could reduce agitation and aggression in dementia. Estrogen has been reported helpful for these symptoms, but adverse effects are problematic. Chronic administration of the synthetic gonadotropin (luteinising hormone) releasing hormone analogue, goserelin, reduces testosterone activity. Here we describe the apparently sustained elimination of previously treatment-resistant agitation and aggression with goserelin treatment in a 78-year-old male nursing-home resident with Alzheimer's disease. JF - International psychogeriatrics AU - Rosin, Richard A AU - Raskind, Murray A AD - Department of Veterans Affairs, Puget Sound Health Care System Mental Illness Research, Education, and Clinical Center (MIRECC), Seattle, WA 98108, USA. richard.rosin@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 313 EP - 318 VL - 17 IS - 2 SN - 1041-6102, 1041-6102 KW - Amines KW - 0 KW - Antipsychotic Agents KW - Cyclohexanecarboxylic Acids KW - Dibenzothiazepines KW - Goserelin KW - 0F65R8P09N KW - Benzodiazepines KW - 12794-10-4 KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Testosterone KW - 3XMK78S47O KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Valproic Acid KW - 614OI1Z5WI KW - gabapentin KW - 6CW7F3G59X KW - Propranolol KW - 9Y8NXQ24VQ KW - Risperidone KW - L6UH7ZF8HC KW - olanzapine KW - N7U69T4SZR KW - Trazodone KW - YBK48BXK30 KW - Index Medicus KW - Trazodone -- therapeutic use KW - Humans KW - Aged KW - Amines -- therapeutic use KW - Cyclohexanecarboxylic Acids -- therapeutic use KW - Propranolol -- therapeutic use KW - Benzodiazepines -- therapeutic use KW - gamma-Aminobutyric Acid -- therapeutic use KW - Testosterone -- blood KW - Treatment Outcome KW - Valproic Acid -- therapeutic use KW - Risperidone -- therapeutic use KW - Dibenzothiazepines -- therapeutic use KW - Male KW - Gonadotropin-Releasing Hormone -- agonists KW - Aggression -- drug effects KW - Alzheimer Disease -- complications KW - Aggression -- psychology KW - Antipsychotic Agents -- therapeutic use KW - Alzheimer Disease -- drug therapy KW - Alzheimer Disease -- psychology KW - Antipsychotic Agents -- adverse effects KW - Goserelin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68085587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+psychogeriatrics&rft.atitle=Gonadotrophin-releasing+hormone+agonist+treatment+of+aggression+in+Alzheimer%27s+disease%3A+a+case+report.&rft.au=Rosin%2C+Richard+A%3BRaskind%2C+Murray+A&rft.aulast=Rosin&rft.aufirst=Richard&rft.date=2005-06-01&rft.volume=17&rft.issue=2&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=International+psychogeriatrics&rft.issn=10416102&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-27 N1 - Date created - 2005-07-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuroleptic malignant syndrome in a patient with Parkinson's disease: a case study. AN - 68013435; 16001822 AB - Neuroleptic malignant syndrome (NMS) is a potentially lethal condition that has been described in patients with idiopathic Parkinson's disease (PD) after long-term dopaminergic medications are suddenly stopped or moderately decreased. If patients with PD develop severe rigidity, stupor, and hyperthermia, L-Dopa withdrawal should be suspected and the dopaminergic drug restarted as soon as possible to prevent rhabdomyolysis and renal failure. Nurses who are knowledgeable about NMS can provide prompt identification of the PD patient's condition and prevent a potentially lethal cascade of symptoms. JF - The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses AU - Ward, Constance AD - Neurology Care Line-127PD 2002 Holcombe Blvd., Houston, TX 77030, USA. constance.ward@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 160 EP - 162 VL - 37 IS - 3 SN - 0888-0395, 0888-0395 KW - Antiparkinson Agents KW - 0 KW - Dopamine Agents KW - Electrolytes KW - Muscle Relaxants, Central KW - Levodopa KW - 46627O600J KW - Dantrolene KW - F64QU97QCR KW - Index Medicus KW - Nursing KW - Magnetic Resonance Imaging KW - Humans KW - Aged KW - Dantrolene -- therapeutic use KW - Physical Examination KW - Leukocyte Count KW - Electrolytes -- blood KW - Fever -- etiology KW - Confusion -- etiology KW - Dehydration -- etiology KW - Nursing Assessment KW - Deep Brain Stimulation KW - Muscle Relaxants, Central -- therapeutic use KW - Drug Monitoring KW - Nurse's Role KW - Urinalysis KW - Time Factors KW - Male KW - Antiparkinson Agents -- adverse effects KW - Neuroleptic Malignant Syndrome -- etiology KW - Substance Withdrawal Syndrome -- complications KW - Parkinson Disease -- therapy KW - Neuroleptic Malignant Syndrome -- diagnosis KW - Parkinson Disease -- complications KW - Dopamine Agents -- adverse effects KW - Neuroleptic Malignant Syndrome -- therapy KW - Levodopa -- adverse effects KW - Neuroleptic Malignant Syndrome -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68013435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.atitle=Neuroleptic+malignant+syndrome+in+a+patient+with+Parkinson%27s+disease%3A+a+case+study.&rft.au=Ward%2C+Constance&rft.aulast=Ward&rft.aufirst=Constance&rft.date=2005-06-01&rft.volume=37&rft.issue=3&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.issn=08880395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-08 N1 - Date created - 2005-07-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Repeated psychological stress testing in stimulant-dependent patients. AN - 67991531; 15913869 AB - Decreasing response to stress has been one goal of interventions aimed at reducing relapse to substances of abuse. A laboratory stress test that can be repeated would be helpful in testing the efficacy of interventions in decreasing the response to stress before more extensive trials are begun. The effects of two types of psychological stress tests, the Trier Social Stress Test (TSST) and a stress imagery test, on psychological, physiological, and hormonal responses (salivary cortisol and DHEA) were examined when each test was given twice to cocaine- or methamphetamine-dependent human subjects, 24 of whom completed at least one session. The stress imagery test produced significant changes in several of the subjective response measures in both first and second sessions, including several measures of negative affect and a craving measure. The TSST produced significant changes only in the second session. The stress imagery protocol showed better replicability across two sessions. Cocaine users and methamphetamine users did not respond similarly in their craving responses. Reported craving for methamphetamine after stress testing showed decreases or much smaller increases compared to that for cocaine. Neither stress test significantly increased salivary cortisol or DHEA, and changes in hormone concentrations were not related to subjective responses. These results suggest that stress imagery testing procedures may be useful as provocative tests of stress-induced affect and stimulant drug craving. Although less convincing because of the heterogeneity of the subjects, they also suggest that HPA axis responsivity is not clearly linked to acute stress-induced stimulant craving or affective response. JF - Progress in neuro-psychopharmacology & biological psychiatry AU - Harris, Debra S AU - Reus, Victor I AU - Wolkowitz, Owen M AU - Mendelson, John E AU - Jones, Reese T AD - Drug Dependence Research Center, Langley Porter Psychiatric Institute, Department of Psychiatry, University of California, San Francisco, CA, USA. debra.harris@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 669 EP - 677 VL - 29 IS - 5 SN - 0278-5846, 0278-5846 KW - Central Nervous System Stimulants KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Dehydroepiandrosterone KW - 459AG36T1B KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Blood Pressure -- physiology KW - Affect -- drug effects KW - Humans KW - Cocaine-Related Disorders -- psychology KW - Aged KW - Amphetamine-Related Disorders -- psychology KW - Hydrocortisone -- metabolism KW - Smoking -- psychology KW - Dehydroepiandrosterone -- metabolism KW - Imagination KW - Psychiatric Status Rating Scales KW - Saliva -- metabolism KW - Middle Aged KW - Blood Pressure -- drug effects KW - Female KW - Male KW - Social Environment KW - Stress, Psychological -- diagnosis KW - Substance-Related Disorders -- psychology KW - Stress, Psychological -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67991531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+neuro-psychopharmacology+%26+biological+psychiatry&rft.atitle=Repeated+psychological+stress+testing+in+stimulant-dependent+patients.&rft.au=Harris%2C+Debra+S%3BReus%2C+Victor+I%3BWolkowitz%2C+Owen+M%3BMendelson%2C+John+E%3BJones%2C+Reese+T&rft.aulast=Harris&rft.aufirst=Debra&rft.date=2005-06-01&rft.volume=29&rft.issue=5&rft.spage=669&rft.isbn=&rft.btitle=&rft.title=Progress+in+neuro-psychopharmacology+%26+biological+psychiatry&rft.issn=02785846&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-26 N1 - Date created - 2005-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mentoring surgeons in private and academic practice. AN - 67951141; 15967909 AB - Mentoring is an essential component of a successful career in any profession, and these relationships are beginning to be explored in great detail in academic surgery. However, it is equally important for surgeons in private practice, and this area has not received nearly as much attention in the literature. The goals for both are similar and include providing career advice, guidance, and counseling, with the only regard being the success of the junior associate. In private practice, the mentor can be a senior colleague who may or may not be part of one's group practice. In academia, it may be someone at another university, although proximity is preferable. It may be necessary to repeat the search for a mentor more than once before a successful relationship evolves. This complex process must be mastered if one is to be successful in either academia or private practice. JF - Archives of surgery (Chicago, Ill. : 1960) AU - Hoover, Eddie L AD - Department of Surgery, Buffalo Veterans Affairs Medical Center and State University of New York at Buffalo, 14215, USA. eddie.hoover@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 598 EP - 608 VL - 140 IS - 6 SN - 0004-0010, 0004-0010 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Life Change Events KW - Substance-Related Disorders KW - Faculty, Medical KW - Schools, Medical KW - Private Practice KW - Interpersonal Relations KW - General Surgery -- education KW - Mentors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67951141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+surgery+%28Chicago%2C+Ill.+%3A+1960%29&rft.atitle=Mentoring+surgeons+in+private+and+academic+practice.&rft.au=Hoover%2C+Eddie+L&rft.aulast=Hoover&rft.aufirst=Eddie&rft.date=2005-06-01&rft.volume=140&rft.issue=6&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=Archives+of+surgery+%28Chicago%2C+Ill.+%3A+1960%29&rft.issn=00040010&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-05 N1 - Date created - 2005-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Functioning and health service use among elderly nursing home residents with alcohol use disorders: findings from the National Nursing Home Survey. AN - 67929670; 15956267 AB - The author asked whether older nursing home residents with alcohol use disorders differ from demographically-matched residents without alcohol use disorders on functioning, admission characteristics, and health services use. National Nursing Home Survey data were used to compare nursing home residents with alcohol use disorders (N=216) with demographically-matched residents without alcohol use disorders (N=216) on functioning, admission characteristics, and health services use. Residents with alcohol use disorders functioned somewhat better than did residents in the demographically-matched sample group, as indicated by performance of basic activities of daily living. However, they were significantly more likely to have lived alone before admission and to have obtained mental health and social services. There was a significant group x gender interaction on length of stay: men with alcohol use disorders had shorter lengths of stay than did men without alcohol use disorders; women with alcohol use disorders had longer lengths of stay than did women without such disorders. Having fewer social resources may contribute to elevated admission risk and need for mental health and social services among older nursing home residents who have alcohol use disorders. Duration and severity of alcohol problems may help explain gender differences in length of stay among these residents. JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry AU - Brennan, Penny L AD - Center for Health Care Evaluation (152- VA Palo Alto Health Care System, Menlo Park Division, 795 Willow Road, Menlo Park, CA 94025, USA. penny.brennan@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 475 EP - 483 VL - 13 IS - 6 SN - 1064-7481, 1064-7481 KW - Index Medicus KW - Demography KW - Humans KW - Patient Admission -- statistics & numerical data KW - Mental Health Services -- utilization KW - Aged KW - Activities of Daily Living KW - United States -- epidemiology KW - Male KW - Female KW - Social Work -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Health Services -- utilization KW - Surveys and Questionnaires KW - Nursing Homes -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67929670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+geriatric+psychiatry+%3A+official+journal+of+the+American+Association+for+Geriatric+Psychiatry&rft.atitle=Functioning+and+health+service+use+among+elderly+nursing+home+residents+with+alcohol+use+disorders%3A+findings+from+the+National+Nursing+Home+Survey.&rft.au=Brennan%2C+Penny+L&rft.aulast=Brennan&rft.aufirst=Penny&rft.date=2005-06-01&rft.volume=13&rft.issue=6&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+geriatric+psychiatry+%3A+official+journal+of+the+American+Association+for+Geriatric+Psychiatry&rft.issn=10647481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-06-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A survey of PTSD screening and referral practices in VA addiction treatment programs. AN - 67882615; 15925265 AB - Veterans with posttraumatic stress disorder (PTSD) and substance use disorders (SUDs) demonstrate worse outcomes following treatment for SUDs than do veterans with SUDs only, and so PTSD treatment may enhance SUD outcomes for patients. A survey of current practice patterns in VA SUD treatment programs was undertaken to determine their concurrence with emerging practice guidelines for the assessment and treatment of SUD-PTSD comorbidity. Clinicians in outpatient SUD clinics and/or inpatient SUD programs were surveyed in six VA medical centers in 1999 and 2001 (respondents n = 57 and n = 39, respectively). Although one half to two thirds of clinicians working with SUD patients routinely screen for trauma exposure and PTSD, few assessments are systematically conducted using validated measures. Routine referrals to PTSD specialty and dual-diagnosis programs and to veterans' centers are made by between 35% and 60% of providers across inpatient and outpatient settings. Implications for improvement of clinical outcomes are discussed. JF - Journal of substance abuse treatment AU - Young, Helena E AU - Rosen, Craig S AU - Finney, John W AD - National Center for PTSD, VA Palo Alto Health Care System, Menlo Park, CA 94025, USA. helena.young@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 313 EP - 319 VL - 28 IS - 4 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - United States Department of Veterans Affairs KW - Humans KW - United States -- epidemiology KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Referral and Consultation -- statistics & numerical data KW - Substance Abuse Treatment Centers KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Surveys and Questionnaires KW - Substance-Related Disorders -- rehabilitation KW - Mass Screening -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67882615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=A+survey+of+PTSD+screening+and+referral+practices+in+VA+addiction+treatment+programs.&rft.au=Young%2C+Helena+E%3BRosen%2C+Craig+S%3BFinney%2C+John+W&rft.aulast=Young&rft.aufirst=Helena&rft.date=2005-06-01&rft.volume=28&rft.issue=4&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-08 N1 - Date created - 2005-05-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pain and use of alcohol to manage pain: prevalence and 3-year outcomes among older problem and non-problem drinkers. AN - 67874741; 15918808 AB - Most older adults report having recently experienced pain, and many older adults have late-life drinking problems. However, to our knowledge, the intersection of pain and alcohol misuse by older adults has not been studied. This research focuses on the implications of pain for older individuals who have problems with alcohol. Longitudinal survey. SETTING, PARTICIPANTS AND MEASUREMENT: Older community-residing adults (n = 401) were classified as problem and non-problem drinkers. At baseline and 3 years later they were asked to provide information about their pain, use of alcohol to manage pain, drinking behavior, chronic health problems and recent serious injury. At baseline, older problem drinkers reported more severe pain, more disruption of daily activities due to pain and more frequent use of alcohol to manage pain than did older non-problem drinkers. More pain was associated with more use of alcohol to manage pain; this relationship was stronger among older adults with drinking problems than among those without drinking problems. Among older men, more baseline drinking problems interacted with use of alcohol to manage pain to predict more health problems and serious injury 3 years later. Among older women, more baseline drinking problems interacted with use of alcohol to manage pain to predict more drinking problems 3 years later. The results highlight the importance of monitoring the drinking behavior of older patients who present with pain complaints, especially patients who have pre-existing problems with alcohol. JF - Addiction (Abingdon, England) AU - Brennan, Penny L AU - Schutte, Kathleen K AU - Moos, Rudolf H AD - Center for Health Care Evaluation and Program Evaluation and Resource Center, VA Palo Alto Health Care System and Stanford University Medical Center, CA, USA. penny.brennan@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 777 EP - 786 VL - 100 IS - 6 SN - 0965-2140, 0965-2140 KW - Index Medicus KW - Pain Management KW - Attitude to Health KW - Risk Factors KW - Humans KW - Surveys and Questionnaires KW - Aged KW - Activities of Daily Living KW - Middle Aged KW - Longitudinal Studies KW - Male KW - Female KW - Prevalence KW - Alcoholism -- epidemiology KW - Pain -- psychology KW - Alcohol Drinking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67874741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Pain+and+use+of+alcohol+to+manage+pain%3A+prevalence+and+3-year+outcomes+among+older+problem+and+non-problem+drinkers.&rft.au=Brennan%2C+Penny+L%3BSchutte%2C+Kathleen+K%3BMoos%2C+Rudolf+H&rft.aulast=Brennan&rft.aufirst=Penny&rft.date=2005-06-01&rft.volume=100&rft.issue=6&rft.spage=777&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-28 N1 - Date created - 2005-05-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Addiction. 2005 Jun;100(6):731-2 [15918799] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phenazopyridine-induced sulfhemoglobinemia. AN - 67833697; 15886294 AB - To report a case of sulfhemoglobinemia in a patient receiving phenazopyridine for a urinary tract infection. A 63-year-old white woman presented to the emergency department with complaints of fatigue and bluish discoloration of her body that had gradually progressed over the previous 6-8 weeks. About 4 months prior to presenting to the emergency department, she had started taking phenazopyridine, an over-the-counter medication for symptoms of dysuria. Because the cyanosis did not improve after the patient received oxygen and methylene blue, sulfhemoglobinemia was suspected and confirmed by spectrophotometer analysis. Sulfhemoglobin is a green-pigmented molecule containing a sulfur atom in one or more of the porphyrin rings. It is a rare cause of cyanosis, which is usually drug induced. Sulfhemoglobinemia is suspected when a cyanotic patient has normal to near-normal oxygen tension, laboratory reports of elevated methemoglobin, and does not respond to methylene blue therapy. Sulfhemoglobinemia is relatively rare, despite the widespread use of drugs that have been reported to cause it. Predisposing factors, such as chronic constipation, present in our patient, have been suggested as a source of hydrogen sulfide. This case of sulfhemoglobinemia, which occurred after the patient took phenazopyridine, is considered a probable adverse event according to the Naranjo probability scale. JF - The Annals of pharmacotherapy AU - Gopalachar, Anuradha S AU - Bowie, Venita L AU - Bharadwaj, Parag AD - Amarillo Veterans Affairs Medical Center, Amarillo, TX 79106-1991, USA. Anuradha.gopalachar@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 1128 EP - 1130 VL - 39 IS - 6 SN - 1060-0280, 1060-0280 KW - Phenazopyridine KW - K2J09EMJ52 KW - Index Medicus KW - Administration, Oral KW - Urinary Tract Infections -- drug therapy KW - Humans KW - Middle Aged KW - Female KW - Phenazopyridine -- adverse effects KW - Phenazopyridine -- administration & dosage KW - Sulfhemoglobinemia -- diagnosis KW - Sulfhemoglobinemia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67833697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Phenazopyridine-induced+sulfhemoglobinemia.&rft.au=Gopalachar%2C+Anuradha+S%3BBowie%2C+Venita+L%3BBharadwaj%2C+Parag&rft.aulast=Gopalachar&rft.aufirst=Anuradha&rft.date=2005-06-01&rft.volume=39&rft.issue=6&rft.spage=1128&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2005-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A psychometric evaluation of the Fagerström Test for Nicotine Dependence in PTSD smokers. AN - 67827471; 15893100 AB - Rates of smoking among individuals with psychiatric conditions are greater than rates seen in the general population, yet little is known about the psychometric properties of commonly used nicotine dependence instruments among psychiatric smokers. This study examined the reliability, validity, and factor structure of the Fagerström Test for Nicotine Dependence (FTND) among psychiatric smokers. Results revealed that the FTND had good test-retest reliability, convergent validity, and discriminant validity. A factor-analytic examination converged on a two-factor solution, reflecting two correlated but separate processes related to nicotine dependence. In total, the results revealed that the FTND performs as well--from a psychometric perspective--with psychiatric smokers, as it does with nonpsychiatric smokers. JF - Addictive behaviors AU - Buckley, Todd C AU - Mozley, Susannah L AU - Holohan, Dana R AU - Walsh, Kate AU - Beckham, Jean C AU - Kassel, Jon D AD - National Center for PTSD, VA Boston Healthcare System, MA 02131-4817, USA. Todd.Buckley@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 1029 EP - 1033 VL - 30 IS - 5 SN - 0306-4603, 0306-4603 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Reproducibility of Results KW - Humans KW - Nicotine -- analysis KW - Middle Aged KW - Male KW - Female KW - Stress Disorders, Post-Traumatic -- psychology KW - Stress Disorders, Post-Traumatic -- complications KW - Psychometrics -- methods KW - Psychological Tests -- standards KW - Tobacco Use Disorder -- psychology KW - Smoking -- psychology KW - Tobacco Use Disorder -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67827471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=A+psychometric+evaluation+of+the+Fagerstr%C3%B6m+Test+for+Nicotine+Dependence+in+PTSD+smokers.&rft.au=Buckley%2C+Todd+C%3BMozley%2C+Susannah+L%3BHolohan%2C+Dana+R%3BWalsh%2C+Kate%3BBeckham%2C+Jean+C%3BKassel%2C+Jon+D&rft.aulast=Buckley&rft.aufirst=Todd&rft.date=2005-06-01&rft.volume=30&rft.issue=5&rft.spage=1029&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-13 N1 - Date created - 2005-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of novel genetic loci for bone size and mechanosensitivity in an ENU mutant exhibiting decreased bone size. AN - 67810450; 15883645 AB - Using a dominant ENU mutagenesis screen in C57BL/6J (B6) mice to reveal gene function, we identified a mutant, 917M, with a reduced bone size phenotype, which is expressed only in males. We show that mutation results in osteoblasts with reduced proliferation, increased apoptosis, and an impaired response to in vitro mechanical load. The mutation is mapped to a novel locus (LOD score of 7.9 at 10.5 cM) on chromosome 4. Using a dominant ENU mutagenesis screen in C57BL/6J (B6) mice to reveal gene function, we identified a mutant, 917M, with a reduced bone size phenotype, which is expressed only in males. In this report, we show the chromosomal location of this mutation using linkage analysis and cellular characterization of the mutant phenotype. The mutant mouse was bred to wildtype B6 to produce progeny for characterization of the bone size phenotype. Periosteal osteoblasts isolated from the tibia and femur of mutant and wildtype mice were studied for proliferation, differentiation, and apoptosis potential. To determine the chromosomal location of the mutation, a low-resolution linkage map was established by completing a genome-wide scan in B6C3H F2 male mice generated from intercross breeding of mutant mice. Mutant progeny (16 weeks old) displayed a total body bone area that was 10-13% lower and a periosteal circumference that was 5-8% lower at the femur and tibia midshaft compared with wildtype B6 mice. Periosteal osteoblasts from mutant mice showed 17-27% reduced cell proliferation and 23% increased apoptosis compared with wildtype controls. In addition, osteoblasts from mutant mice showed an impaired response to shear stress-induced proliferation rate, an in vitro model for mechanical loading. Interval mapping in B6C3H F2 males (n = 69) indicated two major loci affecting bone size on chromosome 1 at 45 cM (LOD 4.9) and chromosome 4 at 10.5 cM (LOD 7.9, genome-wide p < 0.01). Interval mapping using body weight as covariate revealed only one significant interval at chromosome 4 (LOD 6.8). Alleles of the chromosome 4 interval inherited from the B6 mutant strain contributed to a significantly lower bone size than those inherited from C3H. A pairwise interaction analysis showed evidence for a significant interaction between loci on chromosome 1 with the chromosome 4 quantitative trait loci. The 917M locus on chromosome 4 seems to be novel because it does not correspond with those loci previously associated with bone size on chromosome 4 in B6 and C3H/HeJ mice or other crosses. JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research AU - Srivastava, Apurva K AU - Kapur, Sanjay AU - Mohan, Suburaman AU - Yu, Hongrun AU - Kapur, Sonia AU - Wergedal, Jon AU - Baylink, David J AD - Musculoskeletal Disease Center, Jerry L. Pettis Veterans Administration Medical Center, Loma Linda, California 92357, USA. Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 1041 EP - 1050 VL - 20 IS - 6 SN - 0884-0431, 0884-0431 KW - Alkylating Agents KW - 0 KW - Mutagens KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Osteoblasts -- metabolism KW - Animals KW - Apoptosis KW - Sex Factors KW - Bone Resorption KW - Quantitative Trait Loci KW - Cell Differentiation KW - Mice KW - Cell Proliferation KW - Chromosome Mapping KW - Genome KW - Osteoblasts -- cytology KW - Phenotype KW - Alleles KW - Lod Score KW - Stress, Mechanical KW - Models, Genetic KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Crosses, Genetic KW - Mutation KW - Female KW - Male KW - Bone and Bones -- physiology KW - Bone and Bones -- drug effects KW - Bone and Bones -- anatomy & histology KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67810450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.atitle=Identification+of+novel+genetic+loci+for+bone+size+and+mechanosensitivity+in+an+ENU+mutant+exhibiting+decreased+bone+size.&rft.au=Srivastava%2C+Apurva+K%3BKapur%2C+Sanjay%3BMohan%2C+Suburaman%3BYu%2C+Hongrun%3BKapur%2C+Sonia%3BWergedal%2C+Jon%3BBaylink%2C+David+J&rft.aulast=Srivastava&rft.aufirst=Apurva&rft.date=2005-06-01&rft.volume=20&rft.issue=6&rft.spage=1041&rft.isbn=&rft.btitle=&rft.title=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.issn=08840431&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-03 N1 - Date created - 2005-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Using Remote Assessment to Provide Home Modification Services to Underserved Elders AN - 61433250; 200505255 AB - Purpose: Although remote home assessment would enable specialists to prescribe home modifications for anyone, anywhere, the strategy is dependent on the ability to provide specialists with the same information as an in-home assessment. The purpose of this paper is to document that remote assessment is feasible & concurs largely with traditional in-home assessment based on expert judgment. Design and Methods: We compared two new remote assessments, a "zero-tech" paper-&-pencil protocol & a "high-tech" televideo protocol, to traditional in-home assessments to determine the equivalence of the remote & in-home assessments. We determined equivalence by comparing each of the remote assessments to a traditional in-home assessment in the same home. In-home assessments were conducted by home-modification specialists in all homes. Data collection for the remote protocols was conducted by individuals inexperienced in home modification. Assessment data from the remote protocols were analyzed by specialists to diagnose problems & prescribe solutions. Results: The overall rates of correct problem identification (i.e., Sensitivity + Specificity) were significant (p =.000) for both the remote paper-&-pencil (96.4%) & remote televideo (87.1%) protocols. Similarly, rates of agreement in recommendations of solutions were significant (p =.000) for both remote assessments (78.8% & 77.4%, respectively). Implications: The need for home-modification services, particularly in rural areas, far exceeds the capacity of specialists to provide them. Our findings suggest that remote assessments can potentially be used to identify mobility & safety problems in the home as well as to recommend solutions to those problems. As a result, remote home assessment has the potential to provide underserved elders with access to home-modification services that have heretofore eluded them. 2 Tables, 6 Figures, 13 References. Adapted from the source document. JF - The Gerontologist AU - Sanford, Jon A AU - Butterfield, Tina AD - Atlanta VA Medical Center, Rehab R&D Center, Decatur, GA jon.sanford@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 389 EP - 398 VL - 45 IS - 3 SN - 0016-9013, 0016-9013 KW - Home modifications, Aging in place, Home assessment KW - Evaluation KW - Safety KW - Elderly KW - Activities of Daily Living KW - Home Health Care KW - Living Conditions KW - Rural Areas KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61433250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=Using+Remote+Assessment+to+Provide+Home+Modification+Services+to+Underserved+Elders&rft.au=Sanford%2C+Jon+A%3BButterfield%2C+Tina&rft.aulast=Sanford&rft.aufirst=Jon&rft.date=2005-06-01&rft.volume=45&rft.issue=3&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Number of references - 13 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Home Health Care; Elderly; Living Conditions; Evaluation; Rural Areas; Safety; Activities of Daily Living ER - TY - JOUR T1 - Effects of Transdermal Nicotine during Imaginal Exposure to Anxiety and Smoking Cues in College Smokers AN - 57129674; 200601765 AB - In a 2 (patch) x 2 (smoking) x 2 (anxiety) mixed design, 52 undergraduate smokers randomly received a nicotine (21 mg) or placebo patch. After a 4-hr nicotine absorption/deprivation period, participants imagined several scenarios varying in cue content: (a) anxiety plus smoking, (b) anxiety, (c) smoking, and (d) neutral. Although smoking urge increased in both the nicotine and placebo conditions after the absorption/deprivation period, those who received the placebo reported significantly greater urge. During the cue reactivity trials, a significant Patch x Smoking x Anxiety interaction effect was observed for urge. However, participants who received nicotine still experienced moderate urges, indicating that nicotine did not attenuate cue-elicited urge. Transdermal nicotine did not diminish anxiety during the absorption/deprivation period or in response to the cues. Illustrations, Tables, References. [Copyright 2005 The American Psychological Association.] JF - Psychology of Addictive Behaviors AU - Morissette, Sandra Baker AU - Palfai, Tibor P AU - Gulliver, Suzy Bird AU - Spiegel, David A AU - Barlow, David H AD - Veterans Affairs Boston Health Care System, Boston, MA sandra.morissette@med.va.gov Y1 - 2005/06// PY - 2005 DA - June 2005 SP - 192 EP - 198 VL - 19 IS - 2 SN - 0893-164X, 0893-164X KW - Nicotine patches KW - Anxiety KW - Smokers KW - Addiction KW - Undergraduate students KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57129674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+Addictive+Behaviors&rft.atitle=Effects+of+Transdermal+Nicotine+during+Imaginal+Exposure+to+Anxiety+and+Smoking+Cues+in+College+Smokers&rft.au=Morissette%2C+Sandra+Baker%3BPalfai%2C+Tibor+P%3BGulliver%2C+Suzy+Bird%3BSpiegel%2C+David+A%3BBarlow%2C+David+H&rft.aulast=Morissette&rft.aufirst=Sandra&rft.date=2005-06-01&rft.volume=19&rft.issue=2&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Psychology+of+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/10.1037%2F0893-164X.19.2.192 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - PABEEI N1 - SubjectsTermNotLitGenreText - Undergraduate students; Nicotine patches; Addiction; Smokers; Anxiety DO - http://dx.doi.org/10.1037/0893-164X.19.2.192 ER - TY - JOUR T1 - Evaluating Potentially Modifiable Risk Factors for Prevalent and Incident Nocturia in Older Adults AN - 20716248; 6272401 AB - Objectives: To examine associations between nocturia and potentially modifiable risk factors in older adults. Design: Secondary analysis of cross-sectional and longitudinal data. Setting: Respondents were selected using population-based sampling, drawing from a single Michigan county in 1983. They were followed through 1990. Participants: Community-living adults aged 60 and older. Measurements: Episodes of nocturia, development of nocturia at 2 years after baseline survey, age, sex, hypertension, diabetes mellitus, drinking fluids before bedtime, amount of fluid intake before bedtime, diuretic use, and 24-hour coffee intake. All measures were self-reported. Results: Bivariate cross-sectional analysis revealed significant associations with two or more episodes of nocturia for hypertension (odds ratio (OR)=1.7, 95% confidence interval (CI)=1.37-2.1), diabetes mellitus (OR=1.51, 95% CI=1.1-2.0), diuretic use (OR=1.7, 95% CI=1.3-2.1), age (OR=1.05 per additional year over 60, 95% 1.03-1.06), and number of cups of coffee (OR=0.93 for each cup of coffee, 95% CI=0.89-0.97). In multivariate analysis, hypertension (OR=1.52, 95% CI=1.2-1.9), diuretic use (OR=1.3, 95% 95% CI=1.0-1.7), and age (OR=1.04 per additional year over 60, 95% 1.03-1.06) were independently associated with two or more nocturia episodes per night. No baseline factors predicted future development of nocturia (save for age, in one model). Conclusion: Hypertension, older age, and diuretic use were independently associated with two or more episodes of nocturia in cross-sectional analysis. No baseline factor was related to the development of nocturia over a 2-year interval in this sample. Nighttime fluid intake and coffee intake, practices providers commonly target in patients with nocturia, were not associated with nocturia in this population-based sample of community-living older adults. JF - Journal of the American Geriatrics Society AU - Johnson, Theodore M AU - Sattin, Richard W AU - Parmelee, Patricia AU - Fultz, Nancy H AU - Ouslander, Joseph G AD - Theodore M. Johnson II, Birmingham-Atlanta GRECC, 508-11B, Atlanta VAMC, 1670 Clairmont Road, Decatur, GA 30033, Ted.Johnson@med.va.gov Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 1011 EP - 1016 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 53 IS - 6 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - Age KW - diabetes mellitus KW - secondary analysis KW - hypertension KW - coffee KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20716248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Evaluating+Potentially+Modifiable+Risk+Factors+for+Prevalent+and+Incident+Nocturia+in+Older+Adults&rft.au=Johnson%2C+Theodore+M%3BSattin%2C+Richard+W%3BParmelee%2C+Patricia%3BFultz%2C+Nancy+H%3BOuslander%2C+Joseph+G&rft.aulast=Johnson&rft.aufirst=Theodore&rft.date=2005-06-01&rft.volume=53&rft.issue=6&rft.spage=1011&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2005.53321.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - SuppNotes - Figures, 1; tables, 2; references, 30. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - diabetes mellitus; Age; secondary analysis; coffee; hypertension DO - http://dx.doi.org/10.1111/j.1532-5415.2005.53321.x ER - TY - JOUR T1 - CD4 super(+) CD25 super(+) T Cells Prevent Arthritis Associated with Borrelia Vaccination and Infection AN - 17629352; 6416917 AB - CD4 super(+) CD25 super(+) T cells are a population of regulatory T cells associated with control of arthritis in anti-interleukin-17 antibody-treated Borrelia-vaccinated and challenged gamma interferon-deficient mice. Here, we present direct evidence that adoptive transfer of enriched CD4 super(+) CD25 super(+) T cells from these mice can prevent the development of arthritis in Borrelia-vaccinated and challenged mice. These findings establish a major role for CD4 super(+) CD25 super(+) T cells in the prevention of arthritis in Borrelia-vaccinated and challenged animals. JF - Clinical and Diagnostic Laboratory Immunology AU - Nardelli, Dean T AU - Cloute, Joseph P AU - Luk, KHKevin AU - Torrealba, Jose AU - Warner, Thomas F AU - Callister, Steven M AU - Schell, Ronald F AD - Wisconsin State Laboratory of Hygiene. Departments of Comparative Biomedical Sciences. Bacteriology. Medical Microbiology and Immunology. Pathology and Laboratory Medicine. Surgery, University of Wisconsin. Department of Pathology, Veterans Administration Hospital, Madison. Microbiology Research Laboratory and Section of Infectious Diseases, Gundersen Lutheran Medical Center, La Crosse, Wisconsin Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 786 EP - 792 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 12 IS - 6 SN - 1071-412X, 1071-412X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - J 02833:Immune response and immune mechanisms KW - F 06322:Rheumatoid Arthritis: Clinical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17629352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Diagnostic+Laboratory+Immunology&rft.atitle=CD4+super%28%2B%29+CD25+super%28%2B%29+T+Cells+Prevent+Arthritis+Associated+with+Borrelia+Vaccination+and+Infection&rft.au=Nardelli%2C+Dean+T%3BCloute%2C+Joseph+P%3BLuk%2C+KHKevin%3BTorrealba%2C+Jose%3BWarner%2C+Thomas+F%3BCallister%2C+Steven+M%3BSchell%2C+Ronald+F&rft.aulast=Nardelli&rft.aufirst=Dean&rft.date=2005-06-01&rft.volume=12&rft.issue=6&rft.spage=786&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Diagnostic+Laboratory+Immunology&rft.issn=1071412X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Bioactivation of Latent Transforming Growth Factor beta 1 by Mycobacterium tuberculosis in Human Mononuclear Phagocytes AN - 17536570; 6405895 AB - Biologically active transforming growth factor beta 1 (TGF beta 1) has been identified at sites of Mycobacterium tuberculosis (MTB) infection in the lung; however, the underlying mechanism(s) for its activation is not clear. Here using an enzyme-linked immunospot assay for TGF beta 1, we show that human blood monocytes (MN) and alveolar macrophages (AM) produce bioactive TGF beta 1 upon stimulation by MTB. However, only MTB-stimulated MN increased TGF beta 1 production on a per cell basis. The frequency of TGF beta 1-producing MN was reduced by an inhibitor of plasmin, bdellin, indicating a role for plasmin pathways in the bioactivation of cytokine. The expression of urokinase plasminogen activator receptor (uPAR) mRNA and both surface and soluble uPAR (CD87) was increased in MTB-activated MN. However, antibody neutralization of uPAR suppressed bioactive TGF beta 1 in MN alone. Thus, the more immature MN, which are continuously recruited to the lung during tuberculosis (TB), have a higher capacity to bioactivate TGF beta 1 by expression of components of the plasmin pathway. Excess production and bioactivation of TGF beta 1 at sites of MTB infection may undermine host immune responses during TB. JF - Scandinavian Journal of Immunology AU - Aung, H AU - Wu, M AU - Johnson, J L AU - Hirsch, C S AU - Toossi, Z AD - Division of Infectious Disease, Department of Medicine, Case Western Reserve University; and Veterans' Administration Medical Center, Cleveland, OH, USA, zxt2@po.cwru.edu Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 558 EP - 565 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 61 IS - 6 SN - 0300-9475, 0300-9475 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Infection KW - Transforming growth factor-^b1 KW - Transforming growth factor-b1 KW - Phagocytes KW - Transforming growth factor-^b KW - Cytokines KW - Tuberculosis KW - Monocytes KW - Manganese KW - plasminogen KW - Enzyme-linked immunosorbent assay KW - mRNA KW - Blood KW - Plasmin KW - Antibodies KW - Lung KW - u-Plasminogen activator KW - Mycobacterium tuberculosis KW - F 06106:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17536570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Immunology&rft.atitle=Bioactivation+of+Latent+Transforming+Growth+Factor+beta+1+by+Mycobacterium+tuberculosis+in+Human+Mononuclear+Phagocytes&rft.au=Aung%2C+H%3BWu%2C+M%3BJohnson%2C+J+L%3BHirsch%2C+C+S%3BToossi%2C+Z&rft.aulast=Aung&rft.aufirst=H&rft.date=2005-06-01&rft.volume=61&rft.issue=6&rft.spage=558&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Immunology&rft.issn=03009475&rft_id=info:doi/10.1111%2Fj.1365-3083.2005.01623.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - Figures, 7; references, 29. N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Transforming growth factor-b1; Manganese; Plasmin; Infection; Lung; Tuberculosis; u-Plasminogen activator; Monocytes; Phagocytes; Enzyme-linked immunosorbent assay; Cytokines; Transforming growth factor-^b1; Blood; mRNA; Antibodies; Macrophages; plasminogen; Transforming growth factor-^b DO - http://dx.doi.org/10.1111/j.1365-3083.2005.01623.x ER - TY - JOUR T1 - Increased Sensitivity to Staphylococcal Enterotoxin B following Adenoviral Infection AN - 17490751; 6274229 AB - Staphylococcal enterotoxin B induces toxic shock and is a major virulence factor of staphylococcal diseases. We examined the effects of systemic adenoviral infection on responses to staphylococcal enterotoxin B in a murine model. We found that adenoviral infection markedly increases the severity of liver injury following exposure to staphylococcal enterotoxin B without D-galactosamine sensitization. In adenovirus-infected mice, staphylococcal enterotoxin B triggered a more profound hypothermia and increased apoptosis in the liver. Consistent with these observations, we also found that adenoviral infection primed for an increased production of gamma interferon in vivo and in vitro following stimulation with staphylococcal enterotoxin B. Gamma-interferon-knockout mice did not show increased sensitivity to staphylococcal enterotoxin B following adenoviral infection. These data suggest that a preexisting viral infection primes mice for subsequent staphylococcal enterotoxin B exposure, possibly via a gamma-interferon-mediated mechanism. JF - Infection and Immunity AU - Yarovinsky, Timur O AU - Mohning, Michael P AU - Bradford, Mary A AU - Monick, Martha M AU - Hunninghake, Gary W AD - University of Iowa Roy J. and Lucille A. Carver College of Medicine and Veterans Administration Medical Center, Iowa City, Iowa 52242 Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 3375 EP - 3384 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 6 SN - 0019-9567, 0019-9567 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - gamma -Interferon KW - Hypothermia KW - Apoptosis KW - virulence factors KW - Adenovirus KW - Liver KW - Animal models KW - Septic shock KW - staphylococcal enterotoxin B KW - D-Galactosamine KW - J 02822:Biosynthesis and physicochemical properties KW - J 02855:Human Bacteriology: Others KW - V 22150:Animal models & experimentally-induced viral infections UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17490751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Increased+Sensitivity+to+Staphylococcal+Enterotoxin+B+following+Adenoviral+Infection&rft.au=Yarovinsky%2C+Timur+O%3BMohning%2C+Michael+P%3BBradford%2C+Mary+A%3BMonick%2C+Martha+M%3BHunninghake%2C+Gary+W&rft.aulast=Yarovinsky&rft.aufirst=Timur&rft.date=2005-06-01&rft.volume=73&rft.issue=6&rft.spage=3375&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Hypothermia; gamma -Interferon; Apoptosis; virulence factors; Animal models; Liver; Septic shock; D-Galactosamine; staphylococcal enterotoxin B; Adenovirus ER - TY - CPAPER T1 - Role of the xenobiotic receptor PXR in acetaminophen hepatotoxicity AN - 40038246; 3929703 AU - Wolf, K K AU - Wood, S G AU - Walton-Strong, B W AU - Yasuda, K AU - Lan, L AU - Sinclair, PR AU - Wrighton, SA AU - Jeffery, E H AU - Evans, R M AU - Schuetz, E G Y1 - 2005/05/25/ PY - 2005 DA - 2005 May 25 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40038246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+the+xenobiotic+receptor+PXR+in+acetaminophen+hepatotoxicity&rft.au=Wolf%2C+K+K%3BWood%2C+S+G%3BWalton-Strong%2C+B+W%3BYasuda%2C+K%3BLan%2C+L%3BSinclair%2C+PR%3BWrighton%2C+SA%3BJeffery%2C+E+H%3BEvans%2C+R+M%3BSchuetz%2C+E+G&rft.aulast=Wolf&rft.aufirst=K&rft.date=2005-05-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Resont, VA 20190-5332, USA; phone: 703-438-3115; fax: 703-438-3113; URL: http://www.toxicology.org N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - High rates of adverse drug events in a highly computerized hospital. AN - 67852297; 15911723 AB - Numerous studies have shown that specific computerized interventions may reduce medication errors, but few have examined adverse drug events (ADEs) across all stages of the computerized medication process. We describe the frequency and type of inpatient ADEs that occurred following the adoption of multiple computerized medication ordering and administration systems, including computerized physician order entry (CPOE). Using explicit standardized criteria, pharmacists classified inpatient ADEs from prospective daily reviews of electronic medical records from a random sample of all admissions during a 20-week period at a Veterans Administration hospital. We analyzed ADEs that necessitated a changed treatment plan. Among 937 hospital admissions, 483 clinically significant inpatient ADEs were identified, accounting for 52 ADEs per 100 admissions and an incidence density of 70 ADEs per 1000 patient-days. One quarter of the hospitalizations had at least 1 ADE. Of all ADEs, 9% resulted in serious harm, 22% in additional monitoring and interventions, 32% in interventions alone, and 11% in monitoring alone; 27% should have resulted in additional interventions or monitoring. Medication errors contributed to 27% of these ADEs. Errors associated with ADEs occurred in the following stages: 61% ordering, 25% monitoring, 13% administration, 1% dispensing, and 0% transcription. The medical record reflected recognition of 76% of the ADEs. High rates of ADEs may continue to occur after implementation of CPOE and related computerized medication systems that lack decision support for drug selection, dosing, and monitoring. JF - Archives of internal medicine AU - Nebeker, Jonathan R AU - Hoffman, Jennifer M AU - Weir, Charlene R AU - Bennett, Charles L AU - Hurdle, John F AD - Veterans Administration Salt Lake City Health Care System, Geriatric Research, Education, and Clinical Center, Salt Lake City, Utah, USA. Jonathan.Nebeker@hsc.utah.edu Y1 - 2005/05/23/ PY - 2005 DA - 2005 May 23 SP - 1111 EP - 1116 VL - 165 IS - 10 SN - 0003-9926, 0003-9926 KW - Abridged Index Medicus KW - Index Medicus KW - Clinical Pharmacy Information Systems KW - Random Allocation KW - Humans KW - Retrospective Studies KW - Decision Support Systems, Clinical KW - Follow-Up Studies KW - Medication Systems, Hospital KW - Medical Records Systems, Computerized KW - Hospitals, University KW - Drug-Related Side Effects and Adverse Reactions KW - Medication Errors -- statistics & numerical data KW - Drug Therapy, Computer-Assisted UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67852297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=High+rates+of+adverse+drug+events+in+a+highly+computerized+hospital.&rft.au=Nebeker%2C+Jonathan+R%3BHoffman%2C+Jennifer+M%3BWeir%2C+Charlene+R%3BBennett%2C+Charles+L%3BHurdle%2C+John+F&rft.aulast=Nebeker&rft.aufirst=Jonathan&rft.date=2005-05-23&rft.volume=165&rft.issue=10&rft.spage=1111&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-21 N1 - Date created - 2005-05-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 2006 Jun 12;166(11):1235-6; author reply 1236 [16772256] Arch Intern Med. 2006 Jun 12;166(11):1234-5; author reply 1236 [16772255] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of murine macrophage TNF- alpha synthesis by Mycobacterium avium is modulated through complement-dependent interaction via complement receptors 3 and 4 in relation to M. avium glycopeptidolipid AN - 17545113; 6265669 AB - We studied whether complement receptor (CR) mediated Mycobacterium avium interaction modulated macrophage TNF- alpha expression. Compared to control conditions, infections performed with C3-depletion yielded significantly higher TNF- alpha levels. Blockage of the CR4 iC3b site yielded increases in TNF- alpha for all morphotypic variants of a virulent serovar-8 strain (smooth transparent (SmT), smooth opaque (SmO), serovar-specific glycopeptidolipid (ssGPL) deficient knockout mutant) whereas CR3 blockage increased TNF- alpha only for SmT and ssGPL-deficient strains. Thus, complement-mediated binding of M. avium to CR3 and CR4 was shown to modulate TNF- alpha expression. The differential activation of morphotypic and isogenic variants of a single strain provides an excellent model system to delineate signaling pathways. JF - FEMS Microbiology Letters AU - Irani, V R AU - Maslow, J N AD - Division of Infectious Diseases, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States, joel.maslow@med.va.gov Y1 - 2005/05/15/ PY - 2005 DA - 2005 May 15 SP - 221 EP - 228 VL - 246 IS - 2 SN - 0378-1097, 0378-1097 KW - mice KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Mycobacterium avium KW - Complement KW - Animal models KW - Infection KW - Tumor necrosis factor-a KW - Glycopeptidolipids KW - Tumor necrosis factor-^a KW - complement receptor 3 KW - Signal transduction KW - G 07240:Immunogenetics KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17545113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEMS+Microbiology+Letters&rft.atitle=Induction+of+murine+macrophage+TNF-+alpha+synthesis+by+Mycobacterium+avium+is+modulated+through+complement-dependent+interaction+via+complement+receptors+3+and+4+in+relation+to+M.+avium+glycopeptidolipid&rft.au=Irani%2C+V+R%3BMaslow%2C+J+N&rft.aulast=Irani&rft.aufirst=V&rft.date=2005-05-15&rft.volume=246&rft.issue=2&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=FEMS+Microbiology+Letters&rft.issn=03781097&rft_id=info:doi/10.1016%2Fj.femsle.2005.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium avium; Tumor necrosis factor-a; Glycopeptidolipids; Macrophages; Signal transduction; Animal models; Infection; Complement; complement receptor 3; Tumor necrosis factor-^a DO - http://dx.doi.org/10.1016/j.femsle.2005.04.008 ER - TY - JOUR T1 - Integrin alpha5/beta1 expression mediates HER-2 down-regulation in colon cancer cells. AN - 67800945; 15757908 AB - HER-2 is constitutively activated and overexpressed in many cancers, and its inhibition in colon cancer cells diminishes tumorigenicity and induces apoptosis. Little is known about the regulation of HER-2 signaling in colon cancer cells. Integrin alpha5/beta1 expression is frequently lost in colorectal cancer cells compared with normal intestinal epithelium, and colon cancer cells lacking integrin alpha5/beta1 expression utilize HER-2 signaling for proliferation and tumorigenicity. Re-expression of integrin alpha5/beta1 in colon cancer cells abrogated their tumorigenicity, but how this occurs is not well known. Stable expression of integrin alpha5/beta1 in colon cancer cells with little or no detectable integrin alpha5/beta1 protein expression resulted in the post-transcriptional down-regulation of HER-2 protein. Integrin alpha5/beta1 was found to interact with HER-2, and the cytoplasmic domain of integrin alpha5/beta1 was sufficient to mediate HER-2 down-regulation. Integrin alpha5/beta1-mediated down-regulation of HER-2 was the result of increased lysosomal targeting. The inhibition of HER-2 signaling represents a potential mechanism by which integrin alpha5/beta1 exerts its tumor suppressor-like activity in colon cancer cells. These results also suggest that a novel function for integrin alpha5/beta1 is the control of HER-2 expression. JF - The Journal of biological chemistry AU - Kuwada, Scott K AU - Kuang, Jinqiu AU - Li, Xiufen AD - Department of Medicine, Salt Lake City Veterans Administration Health Care System and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA. Y1 - 2005/05/13/ PY - 2005 DA - 2005 May 13 SP - 19027 EP - 19035 VL - 280 IS - 19 SN - 0021-9258, 0021-9258 KW - Integrin alpha5beta1 KW - 0 KW - RNA, Messenger KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Agar KW - 9002-18-0 KW - Receptor, ErbB-2 KW - EC 2.7.10.1 KW - Index Medicus KW - Immunoblotting KW - Blotting, Northern KW - Extracellular Matrix -- metabolism KW - Humans KW - Immunoprecipitation KW - Transcription, Genetic KW - Lysosomes -- metabolism KW - Caco-2 Cells KW - Cell Line, Tumor KW - Cell Proliferation KW - RNA Processing, Post-Transcriptional KW - Biotinylation KW - Mutagenesis, Site-Directed KW - RNA, Messenger -- metabolism KW - Phosphorylation KW - Agar -- chemistry KW - Transfection KW - Cytoplasm -- metabolism KW - Cell Membrane -- metabolism KW - Protein Structure, Tertiary KW - Time Factors KW - Green Fluorescent Proteins -- metabolism KW - Signal Transduction KW - Gene Expression Regulation, Neoplastic KW - Down-Regulation KW - Integrin alpha5beta1 -- biosynthesis KW - Colonic Neoplasms -- pathology KW - Receptor, ErbB-2 -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67800945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Integrin+alpha5%2Fbeta1+expression+mediates+HER-2+down-regulation+in+colon+cancer+cells.&rft.au=Kuwada%2C+Scott+K%3BKuang%2C+Jinqiu%3BLi%2C+Xiufen&rft.aulast=Kuwada&rft.aufirst=Scott&rft.date=2005-05-13&rft.volume=280&rft.issue=19&rft.spage=19027&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-12 N1 - Date created - 2005-05-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Biol Chem. 2005 Aug 5;280(31):28828 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mu-calpain is functionally required for alpha-processing of Alzheimer's beta-amyloid precursor protein. AN - 67706472; 15809056 AB - Alzheimer's beta-amyloid precursor protein (APP) is normally processed by an unidentified alpha-secretase. A unique feature of this protease is its high sensitivity to phorbol esters, yet the mechanism involved is unclear. We have previously reported that phorbol 12,13-dibutyrate (PDBu) activates calpain, a Ca2+-dependent protease, and PDBu-induced release of APPs (secreted APP) is sensitive to calpain inhibitors, suggesting that calpain is involved in APP alpha-processing. In the present study, we found that PDBu markedly promoted the expression of both mu- and m-calpains in cultured fibroblasts. Dose-response and time course studies revealed that mu-calpain was more sensitive to PDBu than m-calpain and the temporal course of the mu-calpain change coincides better with that of APPs release. Moreover, the stimulatory effect of PDBu on mu-calpain was selectively blocked by mu-calpain-specific siRNA (small interference RNA) and the blockage was accompanied by a concomitant decrease in APPs release. In contrast, m-calpain siRNA did not affect APPs release significantly. Measurement of amyloid beta protein (Abeta) release in the mu-calpain siRNA-treated cells indicated that Abeta40 and Abeta42 levels inversely changed in relation to APPs, and the changes in Abeta42 were more prominent than in Abeta40. Together, these data suggest that calpain, particularly mu-calpain, is a potential candidate for alpha-secretase in the regulated APP alpha-processing, and that changes in this protease can affect the outcome of the overall APP processing. JF - Biochemical and biophysical research communications AU - Chen, Ming AU - Fernandez, Hugo L AD - Neurobiology of Aging Research Laboratory, Bay Pines VA Medical Center, Bay Pines, FL 33744, USA. ming.chen@med.va.gov Y1 - 2005/05/13/ PY - 2005 DA - 2005 May 13 SP - 714 EP - 721 VL - 330 IS - 3 SN - 0006-291X, 0006-291X KW - Amyloid beta-Protein Precursor KW - 0 KW - Peptide Fragments KW - RNA, Small Interfering KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Calpain KW - EC 3.4.22.- KW - m-calpain KW - mu-calpain KW - Index Medicus KW - Peptide Fragments -- metabolism KW - Peptide Fragments -- chemistry KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Humans KW - RNA, Small Interfering -- genetics KW - RNA, Small Interfering -- metabolism KW - Cell Line KW - Phorbol 12,13-Dibutyrate -- pharmacology KW - Amyloid beta-Protein Precursor -- chemistry KW - Protein Processing, Post-Translational KW - Amyloid beta-Protein Precursor -- metabolism KW - Alzheimer Disease -- metabolism KW - Calpain -- genetics KW - Calpain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67706472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Mu-calpain+is+functionally+required+for+alpha-processing+of+Alzheimer%27s+beta-amyloid+precursor+protein.&rft.au=Chen%2C+Ming%3BFernandez%2C+Hugo+L&rft.aulast=Chen&rft.aufirst=Ming&rft.date=2005-05-13&rft.volume=330&rft.issue=3&rft.spage=714&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-14 N1 - Date created - 2005-04-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-term neuropsychological outcomes following mild traumatic brain injury. AN - 85382160; pmid-15892899 AB - Mild traumatic brain injury (MTBI) is common, yet few studies have examined neuropsychological outcomes more than 1 year postinjury. Studies of nonreferred individuals with MTBI or studies with appropriate control groups are lacking, but necessary to draw conclusions regarding natural recovery from MTBI. We examined the long-term neuropsychological outcomes of a self-reported MTBI an average of 8 years postinjury in a nonreferred community-dwelling sample of male veterans. This was a cross-sectional cohort study derived from the Vietnam Experience Study. Three groups matched on premorbid cognitive ability were examined, those who (1) had not been injured in a MVA nor had a head injury (Normal Control; n = 3214), (2) had been injured in a motor vehicle accident (MVA) but did not have a head injury (MVA Control; n = 539), and (3) had a head injury with altered consciousness (MTBI; n = 254). A MANOVA found no group differences on a standard neuropsychological test battery of 15 measures. Across 15 measures, the average neuropsychological effect size of MTBI compared with either control group was -.03. Subtle aspects of attention and working memory also were examined by comparing groups on Paced Auditory Serial Addition Test (PASAT) continuation rate and California Verbal Learning Test (CVLT) proactive interference (PI). Compared with normal controls, the MTBI group evidenced attention problems in their lower rate of continuation to completion on the PASAT (odds ratio = 1.32, CI = 1.0-1.73) and in excessive PI (odds ratio = 1.66, CI = 1.11-2.47). Unique to the MTBI group, PASAT continuation problems were associated with left-sided visual imperceptions and excessive PI was associated with impaired tandem gait. These results show that MTBI can have adverse long-term neuropsychological outcomes on subtle aspects of complex attention and working memory. JF - Journal of the International Neuropsychological Society : JINS AU - Vanderploeg, Rodney D AU - Curtiss, Glenn AU - Belanger, Heather G AD - Department of Mental Health and Behavioral Sciences, James A. Haley VAMC, Tampa, Florida 33612, USA. Rodney.Vanderploeg@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 228 EP - 236 VL - 11 IS - 3 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Brain Injuries: complications KW - *Cognition Disorders: diagnosis KW - *Cognition Disorders: etiology KW - Demography KW - Female KW - Humans KW - Male KW - Neuropsychological Tests KW - Severity of Illness Index KW - Time KW - Time Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85382160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Long-term+neuropsychological+outcomes+following+mild+traumatic+brain+injury.&rft.au=Vanderploeg%2C+Rodney+D%3BCurtiss%2C+Glenn%3BBelanger%2C+Heather+G&rft.aulast=Vanderploeg&rft.aufirst=Rodney&rft.date=2005-05-01&rft.volume=11&rft.issue=3&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Factors moderating neuropsychological outcomes following mild traumatic brain injury: a meta-analysis. AN - 85380638; pmid-15892898 AB - There continues to be debate about the long-term neuropsychological impact of mild traumatic brain injury (MTBI). A meta-analysis of the relevant literature was conducted to determine the impact of MTBI across nine cognitive domains. The analysis was based on 39 studies involving 1463 cases of MTBI and 1191 control cases. The overall effect of MTBI on neuropsychological functioning was moderate (d = .54). However, findings were moderated by cognitive domain, time since injury, patient characteristics, and sampling methods. Acute effects (less than 3 months postinjury) of MTBI were greatest for delayed memory and fluency (d = 1.03 and .89, respectively). In unselected or prospective samples, the overall analysis revealed no residual neuropsychological impairment by 3 months postinjury (d = .04). In contrast, clinic-based samples and samples including participants in litigation were associated with greater cognitive sequelae of MTBI (d = .74 and .78, respectively at 3 months or greater). Indeed, litigation was associated with stable or worsening of cognitive functioning over time. The implications and limitations of these findings are discussed. JF - Journal of the International Neuropsychological Society : JINS AU - Belanger, Heather G AU - Curtiss, Glenn AU - Demery, Jason A AU - Lebowitz, Brian K AU - Vanderploeg, Rodney D AD - James A. Haley Veterans' Hospital, Tampa, Florida 33612, USA. Heather.Belanger@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 215 EP - 227 VL - 11 IS - 3 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - *Brain Injuries: complications KW - *Cognition Disorders: diagnosis KW - *Cognition Disorders: etiology KW - Humans KW - Neuropsychological Tests KW - Severity of Illness Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85380638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Factors+moderating+neuropsychological+outcomes+following+mild+traumatic+brain+injury%3A+a+meta-analysis.&rft.au=Belanger%2C+Heather+G%3BCurtiss%2C+Glenn%3BDemery%2C+Jason+A%3BLebowitz%2C+Brian+K%3BVanderploeg%2C+Rodney+D&rft.aulast=Belanger&rft.aufirst=Heather&rft.date=2005-05-01&rft.volume=11&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Patterns of urges during early abstinence in alcohol-dependent subjects. AN - 68033951; 16019975 AB - Urges for alcohol can lead to relapse, but some alcoholics report few urges. We hypothesized that ecological momentary assessment techniques would reveal multiple urge patterns in newly-abstinent alcoholics. Forty-eight alcohol-dependent subjects used PDAs to assess urges to drink in abstinence. Mean and standard deviation of urges were used in cluster analysis, and cluster characteristics were compared. Four clusters were defined, the largest cluster including 29 subjects with low mean urge and low variability. Clusters differed in negative affect and anger but not in abstinence rates. Four distinct urge patterns during abstinence were identified, and 60% of abstinent, alcohol-dependent subjects reported low, stable urge levels. JF - The American journal on addictions AU - Krahn, Dean D AU - Bohn, Michael J AU - Henk, Henry J AU - Grossman, Jennifer L AU - Gosnell, Blake AD - University of Wisconsin, Department of Psychiatry, Madison, WI 53705, USA. dean.krahn@med.va.gov PY - 2005 SP - 248 EP - 255 VL - 14 IS - 3 SN - 1055-0496, 1055-0496 KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Alcohol Drinking -- prevention & control KW - Affect KW - Computers, Handheld KW - Wisconsin KW - Cluster Analysis KW - Secondary Prevention KW - Male KW - Substance Abuse Treatment Centers KW - Motivation KW - Temperance KW - Alcohol-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68033951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Patterns+of+urges+during+early+abstinence+in+alcohol-dependent+subjects.&rft.au=Krahn%2C+Dean+D%3BBohn%2C+Michael+J%3BHenk%2C+Henry+J%3BGrossman%2C+Jennifer+L%3BGosnell%2C+Blake&rft.aulast=Krahn&rft.aufirst=Dean&rft.date=2005-05-01&rft.volume=14&rft.issue=3&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-30 N1 - Date created - 2005-07-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Learning and memory in aging combat veterans with PTSD. AN - 67944295; 15962694 AB - The California Verbal Learning Test (CVLT) was administered to examine learning and memory performance in aging combat veterans with (n = 30) and without PTSD (n = 20), and veterans unexposed to combat (n = 15). Combat veterans with PTSD (PTSD+) showed many impairments compared to non-exposed veterans, but only long-delay free recall consistently discriminated the PTSD+ group from combat-exposed subjects without PTSD (PTSD-), when data were corrected for subscale scores on the WAIS (Vocabulary, Block Design). Alterations in total learning were associated with PTSD when controlling for substance abuse and depression. Two contrast measures, proactive interference and recognition hits, distinguished combat from noncombat veterans, and may be related to trauma exposure. Impairments in total learning are similar to what has been observed in Holocaust survivors. However, increased severity of rapid forgetting may be a specific alteration in older combat veterans, likely reflecting aspects of both combat exposure and aging. JF - Journal of clinical and experimental neuropsychology AU - Yehuda, Rachel AU - Golier, Julia A AU - Tischler, Lisa AU - Stavitsky, Karina AU - Harvey, Philip D AD - Traumatic Stress Studies Program, Psychiatry Department, Mount Sinai School of MedicineNew York, NY, USA. Rachel.Yehuda@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 504 EP - 515 VL - 27 IS - 4 SN - 1380-3395, 1380-3395 KW - Index Medicus KW - Substance-Related Disorders -- physiopathology KW - Neuropsychological Tests -- statistics & numerical data KW - Demography KW - Analysis of Variance KW - Humans KW - Attention -- physiology KW - Aged KW - Middle Aged KW - Language Tests -- statistics & numerical data KW - Male KW - Veterans KW - Aging -- physiology KW - Memory -- physiology KW - Verbal Learning -- physiology KW - Stress Disorders, Post-Traumatic -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67944295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+and+experimental+neuropsychology&rft.atitle=Learning+and+memory+in+aging+combat+veterans+with+PTSD.&rft.au=Yehuda%2C+Rachel%3BGolier%2C+Julia+A%3BTischler%2C+Lisa%3BStavitsky%2C+Karina%3BHarvey%2C+Philip+D&rft.aulast=Yehuda&rft.aufirst=Rachel&rft.date=2005-05-01&rft.volume=27&rft.issue=4&rft.spage=504&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+and+experimental+neuropsychology&rft.issn=13803395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-29 N1 - Date created - 2005-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effectiveness of payment for reduced carbon monoxide levels and noncontingent payments on smoking behaviors in cocaine-abusing outpatients wearing nicotine or placebo patches. AN - 67913809; 15943543 AB - In a 2-week intervention to reduce cigarette smoking among outpatients in treatment for cocaine addiction, 20 subjects were randomly assigned to a contingent group, receiving monetary vouchers for breath samples with carbon monoxide (CO) levels of 8 ppm or less, or to a noncontingent group, receiving vouchers regardless of CO level. Subjects wore either nicotine or placebo patches in a randomized crossover design. Contingent subjects had significantly lower CO levels and met the 8 ppm target significantly more often than did noncontingent subjects; however, number of cigarettes reported smoked did not differ between groups. Use of nicotine patches resulted in CO levels significantly lower than did use of placebo patches, but levels still exceeded 8 ppm regardless of type of patch. Because contingent reward helped cocaine-dependent smokers achieve nonsmoking CO targets, behavioral antismoking interventions merit continued study in similar populations. Copyright 2005 APA, all rights reserved. JF - Experimental and clinical psychopharmacology AU - Wiseman, Eve J AU - Williams, D K AU - McMillan, D E AD - Mental Health Service Line, Central Arkansas Veterans Healthcare System, Little Rock, 72205, USA. Eve.Wiseman@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 102 EP - 110 VL - 13 IS - 2 SN - 1064-1297, 1064-1297 KW - Nicotinic Agonists KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Carbon Monoxide KW - 7U1EE4V452 KW - Index Medicus KW - Administration, Cutaneous KW - Motivation KW - Humans KW - Adult KW - Treatment Outcome KW - Cross-Over Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Carbon Monoxide -- blood KW - Smoking -- therapy KW - Nicotine -- therapeutic use KW - Nicotinic Agonists -- therapeutic use KW - Smoking -- blood KW - Smoking Cessation -- economics KW - Cocaine-Related Disorders -- economics KW - Smoking Cessation -- methods KW - Nicotine -- administration & dosage KW - Cocaine-Related Disorders -- therapy KW - Cocaine-Related Disorders -- blood KW - Smoking -- economics KW - Nicotinic Agonists -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67913809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Effectiveness+of+payment+for+reduced+carbon+monoxide+levels+and+noncontingent+payments+on+smoking+behaviors+in+cocaine-abusing+outpatients+wearing+nicotine+or+placebo+patches.&rft.au=Wiseman%2C+Eve+J%3BWilliams%2C+D+K%3BMcMillan%2C+D+E&rft.aulast=Wiseman&rft.aufirst=Eve&rft.date=2005-05-01&rft.volume=13&rft.issue=2&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-08 N1 - Date created - 2005-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Emerging chemotherapeutic strategies for Huntington's disease. AN - 67903168; 15934871 AB - Huntington's disease (HD) is a progressive and fatal neurological disorder caused by an expanded CAG repeat in the gene coding for the protein, huntingtin. There is no clinically proven treatment for HD. Although the exact cause of neuronal death in HD remains unknown, it has been postulated that the abnormal aggregation of the mutant huntingtin protein may cause toxic effects in neurons, leading to a cascade of pathogenic mechanisms associated with transcriptional dysfunction, oxidative stress, mitochondrial alterations, apoptosis, bioenergetic defects and subsequent excitotoxicity. Understanding how these processes interrelate has become important in identifying a pharmacotherapy in HD and in the design of clinical trials. A number of drug compounds that separately target these mechanisms have significantly improved the clinical and neuropathological phenotype of HD transgenic mice and, as such, are immediate candidates for human clinical trials in HD patients. These compounds are discussed herein. JF - Expert opinion on emerging drugs AU - Ryu, Hoon AU - Ferrante, Robert J AD - Boston University School of Medicine, Edith Nourse Rogers Veterans Administration Medical Center, Bedford, Massachusetts 01730, USA. Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 345 EP - 363 VL - 10 IS - 2 KW - Antineoplastic Agents KW - 0 KW - Coenzymes KW - Drugs, Investigational KW - Ubiquinone KW - 1339-63-5 KW - coenzyme Q10 KW - EJ27X76M46 KW - Index Medicus KW - Animals KW - Humans KW - Ubiquinone -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- chemistry KW - Ubiquinone -- chemistry KW - Ubiquinone -- analogs & derivatives KW - Clinical Trials as Topic -- statistics & numerical data KW - Drugs, Investigational -- therapeutic use KW - Huntington Disease -- metabolism KW - Drug Industry -- trends KW - Drugs, Investigational -- chemistry KW - Huntington Disease -- drug therapy KW - Huntington Disease -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67903168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+emerging+drugs&rft.atitle=Emerging+chemotherapeutic+strategies+for+Huntington%27s+disease.&rft.au=Ryu%2C+Hoon%3BFerrante%2C+Robert+J&rft.aulast=Ryu&rft.aufirst=Hoon&rft.date=2005-05-01&rft.volume=10&rft.issue=2&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+emerging+drugs&rft.issn=1744-7623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-14 N1 - Date created - 2005-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Withdrawal, tolerance, and sensitization to dopamine mediated interoceptive cues in rats trained on a three-lever drug-discrimination task. AN - 67830814; 15894057 AB - In the present experiment rats were trained on a three-lever, drug-discrimination task to discriminate the cues associated with 0.30 mg/kg of the indirect dopamine (DA) agonist, amphetamine (AMPH), saline (SAL), and 0.03 mg/kg of the DA, D2 receptor antagonist, haloperidol (HAL). Choice behavior determined from tests on 0.30 and 0.15 mg/kg AMPH, SAL 0.03 and 0.015 mg/kg HAL provided a behavioral baseline presumed to represent changes along a continuum of DA mediated, interoceptive cues. Results from separate groups tested on 0.30 and 0.15 mg/kg AMPH, SAL, 0.03 and 0.015 mg/kg HAL, 24 h post-treatment with an acute 7.5 mg/kg dose of AMPH, showed rapid tolerance and withdrawal to the AMPH cue and sensitization to the HAL cue. The same tests 24 h following treatment with 1.0 mg/kg HAL showed rapid tolerance to the HAL cue, sensitization to the AMPH cue, but not AMPH-like withdrawal cues. Analysis of the results showed that tolerance to the AMPH and HAL cues reflected neuroadaptive baseline shifts and not weaker cue properties. These findings are consistent with predictions from opponent process theory of motivation and provide an animal model to study the motivational consequences that aversive symptoms of AMPH withdrawal such as dysphoria and anhedonia can have on drug-taking behavior. JF - Pharmacology, biochemistry, and behavior AU - Barrett, Robert J AU - Caul, William F AU - Smith, Randy AD - Veterans Administration Medical Center, Departments of Psychology, Vanderbilt University, 1310 24th Avenue South, Nashville, TN 37212-2637, USA. robert.j.barrett@vanderbilt.edu Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 1 EP - 8 VL - 81 IS - 1 SN - 0091-3057, 0091-3057 KW - Dopamine Agonists KW - 0 KW - Dopamine Antagonists KW - Amphetamine KW - CK833KGX7E KW - Haloperidol KW - J6292F8L3D KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Psychomotor Performance -- drug effects KW - Dose-Response Relationship, Drug KW - Dopamine Agonists -- pharmacology KW - Dopamine Antagonists -- pharmacology KW - Haloperidol -- pharmacology KW - Amphetamine -- pharmacology KW - Male KW - Psychomotor Performance -- physiology KW - Discrimination Learning -- drug effects KW - Discrimination Learning -- physiology KW - Substance Withdrawal Syndrome -- physiopathology KW - Drug Tolerance -- physiology KW - Dopamine -- physiology KW - Cues UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67830814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Withdrawal%2C+tolerance%2C+and+sensitization+to+dopamine+mediated+interoceptive+cues+in+rats+trained+on+a+three-lever+drug-discrimination+task.&rft.au=Barrett%2C+Robert+J%3BCaul%2C+William+F%3BSmith%2C+Randy&rft.aulast=Barrett&rft.aufirst=Robert&rft.date=2005-05-01&rft.volume=81&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-30 N1 - Date created - 2005-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Randomized, controlled trial of a nonpharmacological intervention to improve abnormal sleep/wake patterns in nursing home residents. AN - 67805576; 15877555 AB - Abnormal sleep/wake patterns are common in nursing home residents. Lifestyle and environmental factors likely contribute to these poor sleep patterns. The objective of this study was to test a multidimensional, nonpharmacological intervention to improve abnormal sleep/wake patterns in nursing home residents. Randomized, controlled trial. Four nursing homes in the Los Angeles area. Residents were screened for excessive daytime sleeping (asleep > or = 15% of daytime observations) and nighttime sleep disruption (asleep < 80% of nighttime hours, according to wrist actigraphy). Four hundred ninety-two residents were screened; 339 had excessive daytime sleeping. Of these, 133 had nighttime sleep disruption and consented to participate; 120 completed baseline assessments, and 118 (77% female, mean age 86.9, 90% non-Hispanic white) were randomized to intervention versus usual care. Five consecutive days and nights of efforts to decrease daytime in-bed time, 30 minutes or more of daily sunlight exposure, increased physical activity, structured bedtime routine, and efforts to decrease nighttime noise and light. Seventy-two consecutive hours of wrist actigraphy (nighttime sleep) and structured behavioral observations (daytime sleep and participation in social and physical activities and social conversation) at baseline and repeated at follow-up while the intervention or usual care condition was in place. The only effect on nighttime sleep was a modest decrease in mean duration of nighttime awakenings in intervention participants (10.6 minutes at baseline, 9.8 minutes at follow-up) versus an increase in controls (9.8 minutes at baseline, 13.8 minutes at follow-up) (F=4.27, P=.04). There were no significant effects on percentage of nighttime sleep or number of nighttime awakenings. There was a significant decrease in daytime sleeping in intervention participants (32% of daytime observations asleep at baseline, 21% at follow-up), with no change in controls (32% at baseline, 30% at follow-up; F=20.68, P<.001). Intervention participants had increased participation in social (F=22.42, P<.001) and physical (F=12.65, P=.001) activities and social conversation (F=5.04, P=.03). A multidimensional, nonpharmacological intervention into lifestyle and environmental factors that likely contribute to abnormal sleep/wake patterns in nursing home residents resulted in decreased daytime sleeping and increased participation in social and physical activities and social conversation. Nonpharmacological interventions should be considered in the management of abnormal sleep/wake patterns in nursing home residents. The main effect may be a significant decrease in daytime sleeping, which may translate to an improvement in quality of life. JF - Journal of the American Geriatrics Society AU - Alessi, Cathy A AU - Martin, Jennifer L AU - Webber, Adam P AU - Cynthia Kim, E AU - Harker, Judith O AU - Josephson, Karen R AD - Geriatric Research, Education and Clinical Center; Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California, USA. cathy.alessi@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 803 EP - 810 VL - 53 IS - 5 SN - 0002-8614, 0002-8614 KW - Index Medicus KW - Life Style KW - Aged, 80 and over KW - Humans KW - Interpersonal Relations KW - Treatment Outcome KW - Aged KW - Nursing Homes KW - Male KW - Female KW - Sleep Disorders, Circadian Rhythm -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67805576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Randomized%2C+controlled+trial+of+a+nonpharmacological+intervention+to+improve+abnormal+sleep%2Fwake+patterns+in+nursing+home+residents.&rft.au=Alessi%2C+Cathy+A%3BMartin%2C+Jennifer+L%3BWebber%2C+Adam+P%3BCynthia+Kim%2C+E%3BHarker%2C+Judith+O%3BJosephson%2C+Karen+R&rft.aulast=Alessi&rft.aufirst=Cathy&rft.date=2005-05-01&rft.volume=53&rft.issue=5&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-21 N1 - Date created - 2005-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evidence for PTZ-like cues as a function of time following treatment with chlordiazepoxide: implications for understanding tolerance and withdrawal. AN - 67800183; 15864069 AB - The present study used a two-lever, drug-discrimination procedure to train rats to discriminate between the cues associated with 5 mg/kg of the anxiolytic, chlordiazepoxide (CDP) and 15 mg/kg of the anxiogenic, pentylenetetrazol (PTZ), to investigate the relationship between withdrawal and acute tolerance. Training doses of the two drugs were chosen so that rats responded about equally on both levers when tested on saline (SAL). Following acquisition of the discrimination, rats were injected with 10 mg/kg CDP and tested for lever choice at various intervals from 6 h to 192 h. These tests revealed that cues associated with CDP withdrawal lasted approximately three times longer than the cues associated with the drug's primary effects. At the shortest retest interval (6 h) after treatment with 10 mg/kg CDP, rats responded primarily on the CDP lever, followed by a shift to predominant responding on the PTZ lever at the 16 h and 24 h intervals before returning to predrug, baseline levels at the longer intervals (48-192 h). In order to investigate the relationship between tolerance and withdrawal to the cue properties of CDP, CDP dose-response curves were determined 24 h following treatment with SAL or 10 mg/kg CDP. Acute tolerance, as defined by a rightward, parallel shift in the dose-response function, was observed in the rats pretreated with CDP. Furthermore, it was evident that the baseline shift associated with CDP withdrawal, rather than a weaker drug cue, accounted for acute tolerance. The results from this study are relevant to evaluating the role positive and negative reinforcement play in motivating compulsive drug use. JF - Behavioural pharmacology AU - Barrett, R J AU - Smith, R L AD - Veterans Administration Medical Center, Departments of Psychology and Pharmacology, Vanderbilt University, Vanderbilt School of Medicine, Nashville, Tennessee 37212, USA. r2k2@comcast.net Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 147 EP - 153 VL - 16 IS - 3 SN - 0955-8810, 0955-8810 KW - Anti-Anxiety Agents KW - 0 KW - GABA Agonists KW - Chlordiazepoxide KW - 6RZ6XEZ3CR KW - Pentylenetetrazole KW - WM5Z385K7T KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Reinforcement Schedule KW - Motivation KW - Reinforcement (Psychology) KW - Male KW - Anti-Anxiety Agents -- pharmacology KW - Discrimination Learning KW - Chlordiazepoxide -- pharmacology KW - Substance Withdrawal Syndrome KW - GABA Agonists -- pharmacology KW - Pentylenetetrazole -- pharmacology KW - Anti-Anxiety Agents -- adverse effects KW - Chlordiazepoxide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67800183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+pharmacology&rft.atitle=Evidence+for+PTZ-like+cues+as+a+function+of+time+following+treatment+with+chlordiazepoxide%3A+implications+for+understanding+tolerance+and+withdrawal.&rft.au=Barrett%2C+R+J%3BSmith%2C+R+L&rft.aulast=Barrett&rft.aufirst=R&rft.date=2005-05-01&rft.volume=16&rft.issue=3&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Behavioural+pharmacology&rft.issn=09558810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-13 N1 - Date created - 2005-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans. AN - 67790859; 15855577 AB - Animal and in vitro studies indicate that a decrease in beta-cell insulin secretion, and thus a decrease in tonic alpha-cell inhibition by intraislet insulin, may be an important factor for the increase in glucagon secretion during hypoglycemia. However, in humans this role of decreased intraislet insulin is still unclear. We studied glucagon responses to hypoglycemia in 14 nondiabetic subjects on two separate occasions. On both occasions, insulin was infused from 0 to 120 min to induce hypoglycemia. On one occasion, somatostatin was infused from -60 to 60 min to suppress insulin secretion, so that the decrement in intraislet insulin during the final 60 min of hypoglycemia would be reduced. On the other occasion, subjects received an infusion of normal saline instead of the somatostatin. During the 2nd h of the insulin infusion, when somatostatin or saline was no longer being infused, plasma glucose ( approximately 2.6 mmol/l) and insulin levels ( approximately 570 pmol/l) were comparable in both sets of experiments (both P > 0.4). In the saline experiments, insulin secretion remained unchanged from baseline (-90 to -60 min) before insulin infusion and decreased from 1.20 +/- 0.12 to 0.16 +/- 0.04 pmol . kg(-1) . min(-1) during insulin infusion (P < 0.001). However, in the somatostatin experiments, insulin secretion decreased from 1.18 +/- 0.12 pmol . kg(-1) . min(-1) at baseline to 0.25 +/- 0.09 pmol . kg(-1) . min(-1) before insulin infusion so that it did not decrease further during insulin infusion (-0.12 +/- 0.10 pmol . kg(-1) . min(-1), P = 0.26) indicating the complete lack of a decrement in intraislet insulin during hypoglycemia. This was associated with approximately 30% lower plasma glucagon concentrations (109 +/- 7 vs. 136 +/- 9 pg/ml, P < 0.006) and increments in plasma glucagon above baseline (41 +/- 8 vs. 67 +/- 11 pg/ml, P < 0.008) during the last 15 min of the hypoglycemic clamp. In contrast, increases in plasma growth hormone were approximately 70% greater during hypoglycemia after somatostatin infusion (P < 0.007), suggesting that to some extent the increases in plasma glucagon might have reflected a rebound in glucagon secretion. These results provide direct support for the intraislet insulin hypothesis in humans. However, the exact extent to which a decrement in intraislet insulin accounts for the glucagon responses to hypoglycemia remains to be established. JF - Diabetes care AU - Gosmanov, Niyaz R AU - Szoke, Ervin AU - Israelian, Zarmen AU - Smith, Tamar AU - Cryer, Philip E AU - Gerich, John E AU - Meyer, Christian AD - Carl T. Hayden VA Medical Center, 650 E. Indian School Road, Phoenix, AZ 85012, USA. christian.meyer@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 1124 EP - 1131 VL - 28 IS - 5 SN - 0149-5992, 0149-5992 KW - Blood Glucose KW - 0 KW - C-Peptide KW - Hypoglycemic Agents KW - Insulin KW - Human Growth Hormone KW - 12629-01-5 KW - Somatostatin KW - 51110-01-1 KW - Glucagon KW - 9007-92-5 KW - Hydrocortisone KW - WI4X0X7BPJ KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - C-Peptide -- blood KW - Humans KW - Adult KW - Somatostatin -- administration & dosage KW - Human Growth Hormone -- blood KW - Epinephrine -- blood KW - Male KW - Hydrocortisone -- blood KW - Female KW - Hypoglycemia -- metabolism KW - Glucagon -- secretion KW - Insulin -- blood KW - Hypoglycemic Agents -- administration & dosage KW - Insulin -- secretion KW - Insulin -- administration & dosage KW - Hypoglycemic Agents -- blood KW - Islets of Langerhans -- secretion KW - Hypoglycemia -- chemically induced KW - Glucagon -- blood KW - Islets of Langerhans -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67790859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+care&rft.atitle=Role+of+the+decrement+in+intraislet+insulin+for+the+glucagon+response+to+hypoglycemia+in+humans.&rft.au=Gosmanov%2C+Niyaz+R%3BSzoke%2C+Ervin%3BIsraelian%2C+Zarmen%3BSmith%2C+Tamar%3BCryer%2C+Philip+E%3BGerich%2C+John+E%3BMeyer%2C+Christian&rft.aulast=Gosmanov&rft.aufirst=Niyaz&rft.date=2005-05-01&rft.volume=28&rft.issue=5&rft.spage=1124&rft.isbn=&rft.btitle=&rft.title=Diabetes+care&rft.issn=01495992&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-05 N1 - Date created - 2005-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk-informed, performance-based inspections at medical facilities. AN - 67728336; 15824585 AB - During the past couple of years, radiation safety professionals have observed a significant change with regard to the inspection philosophy of regulators. The NRC and many Agreement State agencies have implemented a performance-based, risk-informed approach for inspecting medical Radiation Safety Programs. This new, less prescriptive approach originates from the necessity to produce safety benefits commensurate with their cost to the industry and still maintain health and safety performance. While compliance with regulatory requirements is important, regulatory agencies have been focusing on areas that provide greater safety benefit, such as protecting the radiation worker, members of the general public and the environment. This paper discusses simple and practical measures that may assist licensees in preparing for performance-based, risk informed inspections. JF - Health physics AU - Michel, René AU - Jacob, Ninni AU - Miller, Ken AU - Zorn, Michael AD - VA San Diego Healthcare System, San Diego, CA, USA. rene.michel@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - S69 EP - S72 VL - 88 IS - 5 Suppl SN - 0017-9078, 0017-9078 KW - Index Medicus KW - United States KW - Occupational Health -- legislation & jurisprudence KW - Health Facilities -- legislation & jurisprudence KW - Health Facilities -- standards KW - Medical Audit -- methods KW - Risk Assessment -- organization & administration KW - Management Audit -- methods KW - Radiation Protection -- legislation & jurisprudence KW - Employee Performance Appraisal -- methods KW - Risk Assessment -- methods KW - Management Audit -- organization & administration KW - Radiation Protection -- standards KW - Medical Audit -- organization & administration KW - Radiation Protection -- methods KW - Employee Performance Appraisal -- organization & administration KW - Safety Management -- methods KW - Health Facility Administration KW - Safety Management -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67728336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Risk-informed%2C+performance-based+inspections+at+medical+facilities.&rft.au=Michel%2C+Ren%C3%A9%3BJacob%2C+Ninni%3BMiller%2C+Ken%3BZorn%2C+Michael&rft.aulast=Michel&rft.aufirst=Ren%C3%A9&rft.date=2005-05-01&rft.volume=88&rft.issue=5+Suppl&rft.spage=S69&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-10 N1 - Date created - 2005-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Growth factors involved in prostate carcinogenesis. AN - 67516593; 15769631 AB - Prostate cancer is the most common non-skin cancer affecting men in United States and the second leading cause of death after lung cancer. The clinical course of patients after given diagnosis of prostate cancer is highly variable and the underlying reasons for such variability remain elusive. To better understand the pathophysiology of prostate cancer, there has been a push to elucidate the molecular mechanisms that mediate the development and progression of prostate cancer. Recent literature has pointed that a complex interplay between various cytokines, growth factors, and androgen receptors regulate the growth and functions of the prostate gland. Amongst the currently implicated anomalous pathways involved in prostate oncogenesis, the IGF-IGFBP axis has been demonstrated to play a very important role, although the precise molecular events regulated by IGF remain to be elucidated. The tumor promoting functions of VEGF has been defined in tumor angiogenesis and currently remains the central focus of anti-angiogenesis therapy in prostate cancer. Another key cytokine, TGF-beta has tumor-suppressor functions in normal prostate gland, but its pleiotropic functions in prostate cancer are influenced by the hormonal state of the disease. In partnership with other deregulated growth factor signaling, the TGF-beta cascade has also been implicated in the spread of prostate cancer. Lastly, members of the EGFR family, particularly the HER2 receptor, have also been recognized as crucial elements of aberrant signal transduction pathways, which induce activation of downstream signaling, involved in cellular proliferation, cell survival, and angiogenesis. The abnormal function of a number of growth factors in prostate cancer biology explains the heterogeneity of its histologic grade, mode of presentation and disease prognosis. At the same time, continued research in this field allows for the potential development of drug therapies against a diverse pool of cancer causing targets. JF - Frontiers in bioscience : a journal and virtual library AU - Kambhampati, Suman AU - Ray, Gibanananda AU - Sengupta, Krishanu AU - Reddy, Venkataprasanth P AU - Banerjee, Sushanta K AU - Van Veldhuizen, Peter J AD - Cancer Research Unit, Kansas City VA Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA. Suman.Kambhampati@med.va.gov Y1 - 2005/05/01/ PY - 2005 DA - 2005 May 01 SP - 1355 EP - 1367 VL - 10 SN - 1093-9946, 1093-9946 KW - Growth Substances KW - 0 KW - Insulin KW - Transforming Growth Factor beta KW - Vascular Endothelial Growth Factor A KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Transforming Growth Factor beta -- physiology KW - Insulin -- physiology KW - Humans KW - Carcinogenicity Tests KW - Vascular Endothelial Growth Factor A -- physiology KW - Receptor, Epidermal Growth Factor -- physiology KW - Male KW - Prostatic Neoplasms -- metabolism KW - Signal Transduction -- physiology KW - Growth Substances -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67516593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+bioscience+%3A+a+journal+and+virtual+library&rft.atitle=Growth+factors+involved+in+prostate+carcinogenesis.&rft.au=Kambhampati%2C+Suman%3BRay%2C+Gibanananda%3BSengupta%2C+Krishanu%3BReddy%2C+Venkataprasanth+P%3BBanerjee%2C+Sushanta+K%3BVan+Veldhuizen%2C+Peter+J&rft.aulast=Kambhampati&rft.aufirst=Suman&rft.date=2005-05-01&rft.volume=10&rft.issue=&rft.spage=1355&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+bioscience+%3A+a+journal+and+virtual+library&rft.issn=10939946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-18 N1 - Date created - 2005-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of stents and abciximab on survival from cardiogenic shock treated with percutaneous coronary intervention AN - 20814750; 10963440 AB - This retrospective observational review compares patient characteristics and in-hospital and long-term outcomes of cohorts of patients undergoing percutaneous coronary intervention (PCI) for cardiogenic shock complicating acute myocardial infarction (MI) prior to the use of stents (as well as glycoprotein IIb/IIIa inhibitor and dual-antiplatelet therapy) with PCI in the stent era. Cardiogenic shock remains the leading cause of hospital mortality from acute MI. This is a report of consecutive patients with cardiogenic shock complicating acute MI, without mechanical complication, referred for emergency catheterization to a single operator at two consecutive Veterans Affairs medical centers over a 15-year period (1988 to August 2003). PCI was attempted in all 93 cases: 44 consecutive patients in the prestent era and 49 consecutive patients in the stent era. Patients with comparable extent of coronary disease, more ST elevation myocardial infarction, multiple areas of infarction, and greater comorbidity underwent PCI in the stent era. Nevertheless, PCI in the stent era was associated with higher rates of acute success and improved in-hospital survival. Kaplan-Meier curves and log-rank testing showed highly significant improvement in overall survival (P < 0.0001). Logistic regression of in-hospital survival demonstrated that stent use (collinear with glycoprotein IIb/IIIa use and dual-antiplatelet therapy) was significantly associated with survival in a model adjusting for extent of coronary disease and comorbidities (P = 0.007). Stents and abciximab have been associated with improved acute angiographic and procedural success of PCI for cardiogenic shock, leading to improved survival. Published 2005 Wiley-Liss, Inc. JF - Catheterization and Cardiovascular Interventions AU - Huang, Raymond AU - Sacks, Jerome AU - Thai, Hoang AU - Goldman, Steven AU - Morrison, Douglass A AU - Barbiere, Charles AU - Ohm, Janet AD - Cardiovascular Disease Sections, Southern Arizona Veterans Affairs Healthcare System and University of Arizona Sarver Heart Center, Tucson, Arizona, douglass.morrison@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 25 EP - 33 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA, [mailto:info@wiley.com], [URL:http://www.wiley.com/WileyCDA/Brand/id-35.html] VL - 65 IS - 1 SN - 1522-1946, 1522-1946 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Mortality KW - Monoclonal antibodies KW - Survival KW - Myocardial infarction KW - Models KW - Catheterization KW - Shock KW - Implants KW - Regression analysis KW - Glycoproteins KW - Heart diseases KW - Hospitals KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20814750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Catheterization+and+Cardiovascular+Interventions&rft.atitle=Impact+of+stents+and+abciximab+on+survival+from+cardiogenic+shock+treated+with+percutaneous+coronary+intervention&rft.au=Huang%2C+Raymond%3BSacks%2C+Jerome%3BThai%2C+Hoang%3BGoldman%2C+Steven%3BMorrison%2C+Douglass+A%3BBarbiere%2C+Charles%3BOhm%2C+Janet&rft.aulast=Huang&rft.aufirst=Raymond&rft.date=2005-05-01&rft.volume=65&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Catheterization+and+Cardiovascular+Interventions&rft.issn=15221946&rft_id=info:doi/10.1002%2Fccd.20334 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Catheterization; Shock; Monoclonal antibodies; Implants; Regression analysis; Survival; Glycoproteins; Myocardial infarction; Models; Hospitals; Heart diseases DO - http://dx.doi.org/10.1002/ccd.20334 ER - TY - JOUR T1 - PROGRESS IN GERIATRICS: Legionnaires' Disease in Long-Term Care Facilities: Overview and Proposed Solutions AN - 19287047; 6252406 AB - Pneumonia is a leading cause of morbidity and mortality in nursing home patients. In acute care hospitals, there is considerable evidence to indicate that Legionnaires' disease is a significant cause of nosocomial pneumonia, the source of which is the potable water system. A relatively limited amount of data exists as to the role of Legionnaires' disease as a cause of pneumonia acquired in long-term care residents. Several lines of evidence suggest that Legionnaires' disease may be an important but underrecognized cause of pneumonia in long-term care residents. These include reports of outbreaks, prospective studies of community-acquired pneumonia that include nursing home patients, and prospective studies of individual long-term care facilities linking Legionnaires' disease to colonization of the potable water system with Legionella. Multiinstitutional studies combining environmental and clinical surveillance for Legionella are needed to further confirm the relationship between colonization of potable water and the occurrence of disease in the long-term care facilities. Until these studies are completed, it is recommended that individual facilities undertake annual sampling of the potable water system for Legionella, coupled with introduction of the rapid Legionella urinary antigen test should L. pneumophila serogroup 1 be found. JF - Journal of the American Geriatrics Society AU - Seenivasan, Meena H AU - Yu, Victor L AU - Muder, Robert R AD - Robert R. Muder, MD, Infectious Disease Section, VA Pittsburgh Healthcare System, University Drive C, Pittsburgh, PA 15240, Robert.Muder@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 875 EP - 880 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 53 IS - 5 SN - 0002-8614, 0002-8614 KW - Microbiology Abstracts B: Bacteriology KW - Mortality KW - Data processing KW - Morbidity KW - Colonization KW - Nursing KW - Reviews KW - Geriatrics KW - Sampling KW - Drinking water KW - Legionella KW - Pneumonia KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19287047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=PROGRESS+IN+GERIATRICS%3A+Legionnaires%27+Disease+in+Long-Term+Care+Facilities%3A+Overview+and+Proposed+Solutions&rft.au=Seenivasan%2C+Meena+H%3BYu%2C+Victor+L%3BMuder%2C+Robert+R&rft.aulast=Seenivasan&rft.aufirst=Meena&rft.date=2005-05-01&rft.volume=53&rft.issue=5&rft.spage=875&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2005.53270.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - SuppNotes - Tables, 2; references, 49. N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Colonization; Data processing; Reviews; Nursing; Geriatrics; Sampling; Drinking water; Morbidity; Pneumonia; Hospitals; Legionella DO - http://dx.doi.org/10.1111/j.1532-5415.2005.53270.x ER - TY - JOUR T1 - Influence of age on noise-and styrene-induced hearing loss in the Long-Evans rat AN - 17846388; 6241804 AB - This paper reviews different investigations carried out with Long-Evans rats on the influence of age on the ototoxicity induced by styrene and on the vulnerability to noise. The first part of this article is focused on the differences in auditory susceptibility to noise (92 or 97 dB octave band noise centered at 8 kHz, 6 h/day, 5 days/week, 4 weeks) and styrene (700 ppm, 6 h/d, 5 d/w, 4 w) between young (three and half months) and old (24 months) Long-Evans rats. Auditory evoked potential measures revealed that the old rats tend to be more sensitive than young rats to higher noise levels (97 dB), but equally vulnerable to moderate levels (92 dB). By contrast, the aged rats were virtually insensitive to 700 ppm styrene compared to the young animals. Two additional studies were performed controlling and examining the influence of body weight and post-natal age on the sensitivity to styrene. Rats of the same age (21 weeks) and but having different body weight ([not, vert, similar]310 g versus [not, vert, similar]410 g) did not show any difference of sensitivity to 700 ppm styrene, whereas 14-week-old rats with the same body weight as 21-week-old rats ([not, vert, similar]350 g) revealed increased sensitivity to styrene. These results show that weight does not play a key role in the sensitivity to styrene, and suggest a long period of increased sensitivity to styrene during the first months of life. JF - Environmental Toxicology and Pharmacology AU - Pouyatos, B AU - Campo, P AU - Lataye, R AD - Institut National de Recherche et de Securite, Ave de Bourgogne, BP 27, 54501 Vandoeuvre, France, benoit.pouyatos@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 561 EP - 570 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 19 IS - 3 SN - 1382-6689, 1382-6689 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Styrene KW - Noise KW - Hearing loss KW - Aging KW - Age KW - Weight KW - Auditory evoked potentials KW - Reviews KW - Ototoxicity KW - N3 11016:Auditory and vestibular systems (including echolocation) KW - X 24154:Pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17846388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Pharmacology&rft.atitle=Influence+of+age+on+noise-and+styrene-induced+hearing+loss+in+the+Long-Evans+rat&rft.au=Pouyatos%2C+B%3BCampo%2C+P%3BLataye%2C+R&rft.aulast=Pouyatos&rft.aufirst=B&rft.date=2005-05-01&rft.volume=19&rft.issue=3&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Pharmacology&rft.issn=13826689&rft_id=info:doi/10.1016%2Fj.etap.2004.12.020 LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - The Ninth Meeting of the International Neurotoxicology Association (INA) N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Auditory evoked potentials; Styrene; Age; Ototoxicity; Reviews; Noise; Hearing loss DO - http://dx.doi.org/10.1016/j.etap.2004.12.020 ER - TY - JOUR T1 - Corynebacterium striatum: an underappreciated community and nosocomial pathogen AN - 17657824; 6446730 AB - Corynebacterium striatum (CS) is an underappreciated human pathogen that has been associated with serious infections in both immunocompetent and immunocompromised hosts. CS infections tend to be more frequent in males and major infection sites have included blood stream, lung, and central nervous system. Most are nosocomially acquired and there is a significant association with medical devices ranging from intravascular catheters to central nervous system drainage devices. Empiric therapy with vancomycin is advisable as susceptibility to other agents is variable. Treatment may also include removal of foreign material such as an intravascular catheter. The present review describes the wide spectrum of infections associated with CS and we add a unique case of CS pancreatic abscess where treatment included linezolid. JF - Journal of Infection AU - Lee, P P AU - Ferguson, DA AU - Sarubbi, F A AD - James H. Quillen VA Medical Center, Mountain Home, TN 37684, USA, felix.sarubbi@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 338 EP - 343 PB - W.B. Saunders Co. Ltd., 32 Jamestown Rd London NW1 7BY United Kingdom, [URL:http://www.harcourt-international.com] VL - 50 IS - 4 SN - 0163-4453, 0163-4453 KW - Microbiology Abstracts B: Bacteriology KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17657824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infection&rft.atitle=Corynebacterium+striatum%3A+an+underappreciated+community+and+nosocomial+pathogen&rft.au=Lee%2C+P+P%3BFerguson%2C+DA%3BSarubbi%2C+F+A&rft.aulast=Lee&rft.aufirst=P&rft.date=2005-05-01&rft.volume=50&rft.issue=4&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infection&rft.issn=01634453&rft_id=info:doi/10.1016%2Fj.jinf.2004.05.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-10-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1016/j.jinf.2004.05.005 ER - TY - JOUR T1 - Oxidative stress: a potential basis for potentiation of noise-induced hearing loss AN - 17523873; 6241821 AB - In the past two decades, researchers have determined that a broad range of environmental and occupational contaminants can interact with noise to enhance noise-induced hearing loss. This manuscript focuses upon the hypothesis that chemicals that promote oxidative stress might increase the risk of noise-induced hearing loss. Evidence is presented that confirms the role of oxidative stress in the production of hearing loss by both carbon monoxide and by acrylonitrile when noise is present at the time of chemical exposure. JF - Environmental Toxicology and Pharmacology AU - Fechter, L D AD - Research Service (151), Jerry L. Pettis Memorial Veterans Medical Center, 11201 Benton St, Loma Linda, CA 92357, USA, larry.fechter@med.va.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 543 EP - 546 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 19 IS - 3 SN - 1382-6689, 1382-6689 KW - acrylonitrile KW - oxidative stress KW - Pollution Abstracts; Health & Safety Science Abstracts; CSA Neurosciences Abstracts KW - Acrylonitrile KW - Auditory perception KW - Public health KW - Carbon monoxide KW - Oxidative stress KW - Occupational exposure KW - Noise levels KW - Hearing loss KW - Noise KW - Contaminants KW - P 7000:NOISE KW - H 1000:Occupational Safety and Health KW - N3 11016:Auditory and vestibular systems (including echolocation) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17523873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Pharmacology&rft.atitle=Oxidative+stress%3A+a+potential+basis+for+potentiation+of+noise-induced+hearing+loss&rft.au=Fechter%2C+L+D&rft.aulast=Fechter&rft.aufirst=L&rft.date=2005-05-01&rft.volume=19&rft.issue=3&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Pharmacology&rft.issn=13826689&rft_id=info:doi/10.1016%2Fj.etap.2004.12.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - SuppNotes - The Ninth Meeting of the International Neurotoxicology Association (INA) N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hearing loss; Occupational exposure; Public health; Noise levels; Carbon monoxide; Contaminants; Noise; Auditory perception; Oxidative stress; Acrylonitrile DO - http://dx.doi.org/10.1016/j.etap.2004.12.017 ER - TY - JOUR T1 - Onset of Overweight during Childhood and Adolescence in Relation to Race and Sex AN - 17337751; 6275212 AB - Overweight [body mass index (BMI) percentile greater than or equal to 95th] in children has become a major public health problem. The age when overweight begins and how it progresses are mostly unknown. Such information would be important for the optimal timing of prevention. We conducted a survival analysis on time to overweight and compared survival curves by race and sex. Data from a cohort of 924 children recruited from schools in Indianapolis, IN, were analyzed. Blacks were at greater risk for becoming overweight than whites. Similar findings were obtained when at risk of overweight (BMI percentile greater than or equal to 85th and <95th) and overweight were considered as a single category. Twenty-five percent of blacks were overweight or at risk of overweight at or before age 7 yr, whereas it was age 11 yr in white females and age 10 yr in white males when 25% became overweight or were at risk of becoming overweight. The overall overweight-free survival curve for black females was significantly different from that for white females (P < 0.001), and black males were significantly different from white males (P = 0.04). There was no sex difference. The time to overweight during childhood and adolescence varies by race, indicating the need for race-specific timing of interventions. JF - Journal of Clinical Endocrinology and Metabolism AU - Saha, Chandan AU - Eckert, George J AU - Pratt, JHoward AU - Shankar, RRavi AD - Departments of Medicine (C.S., G.J.E., J.H.P.) and Pediatrics (R.R.S.), Indiana University, Purdue University at Indianapolis, and the Richard L. Roudebush Veterans Administration Medical Center (J.H.P.), Indianapolis, Indiana 46202 Y1 - 2005/05/01/ PY - 2005 DA - 2005 May 01 SP - 2648 EP - 2652 PB - Endocrine Society, 4350 East West Highway Suite 500 Bethesda MD 20814-4426 USA, [mailto:societyservices@endo-society.org], [URL:http://www.endo-society.org/] VL - 90 IS - 5 SN - 0021-972X, 0021-972X KW - Physical Education Index KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17337751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.atitle=Onset+of+Overweight+during+Childhood+and+Adolescence+in+Relation+to+Race+and+Sex&rft.au=Saha%2C+Chandan%3BEckert%2C+George+J%3BPratt%2C+JHoward%3BShankar%2C+RRavi&rft.aulast=Saha&rft.aufirst=Chandan&rft.date=2005-05-01&rft.volume=90&rft.issue=5&rft.spage=2648&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Psychiatric barriers to readiness for treatment for hepatitis C Virus (HCV) infection among injection drug users: clinical experience of an addiction psychiatrist in the HIV-HCV coinfection clinic of a public health hospital. AN - 67513127; 15768337 AB - Among injection drug users, psychological and psychiatric barriers to readiness for treatment for hepatitis C virus (HCV) infection include mood and anxiety disorders, cognitive deficits, temperament disorders, and personality vulnerabilities, as well as ongoing drug use. Many aspects of these barriers can be overcome with direct treatment or social support. To establish effective treatment for HCV infection in this population of patients, it is essential that the patient and providers develop a rapport that allows for active communication. It is also important that the patient make an effort to adhere to the treatment requirements and that the patient receive the appropriate evaluation and management of treatable barriers. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Scheft, Harriet AU - Fontenette, Dominique C AD - Lemuel Shattuck Hospital, Massachusetts Department of Public Health, Jamaica Plain, MA, USA. harriet.scheft@med.va.gov Y1 - 2005/04/15/ PY - 2005 DA - 2005 Apr 15 SP - S292 EP - S296 VL - 40 Suppl 5 KW - Index Medicus KW - Anxiety Disorders -- psychology KW - Humans KW - Patient Compliance -- psychology KW - Mood Disorders -- complications KW - Personality KW - Substance Abuse, Intravenous -- therapy KW - Substance-Related Disorders -- psychology KW - Anxiety Disorders -- complications KW - Substance-Related Disorders -- therapy KW - Hospitals, Public KW - HIV Infections -- complications KW - Adult KW - Temperament KW - Substance-Related Disorders -- complications KW - Substance Abuse, Intravenous -- complications KW - Psychiatry KW - Physician-Patient Relations KW - Cognition Disorders -- complications KW - Cognition Disorders -- psychology KW - Female KW - Mood Disorders -- psychology KW - Substance Abuse, Intravenous -- psychology KW - Hepatitis C -- therapy KW - Mental Disorders -- therapy KW - Hepatitis C -- complications KW - Mental Disorders -- psychology KW - Patient Selection KW - Hepatitis C -- psychology KW - Mental Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67513127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Psychiatric+barriers+to+readiness+for+treatment+for+hepatitis+C+Virus+%28HCV%29+infection+among+injection+drug+users%3A+clinical+experience+of+an+addiction+psychiatrist+in+the+HIV-HCV+coinfection+clinic+of+a+public+health+hospital.&rft.au=Scheft%2C+Harriet%3BFontenette%2C+Dominique+C&rft.aulast=Scheft&rft.aufirst=Harriet&rft.date=2005-04-15&rft.volume=40+Suppl+5&rft.issue=&rft.spage=S292&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-06 N1 - Date created - 2005-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effect of hearing aids and frequency modulation technology on results from the communication profile for the hearing impaired. AN - 85387356; pmid-16050335 AB - Hearing impairment has been associated with decline in psychosocial function. Previous investigations have reported that the utilization of hearing aids can ameliorate these reductions in psychosocial function. To date, few investigations have examined the effects of frequency modulation technology on hearing handicap, adjustment to hearing loss, and communicative strategies. The purpose of this investigation was to examine these effects and to compare them to the benefits obtained when using hearing aids alone. Subjects ranged in age from 34 to 81 years and had mean pure-tone thresholds consistent with a bilateral moderate to severe sloping sensorineural hearing loss. All subjects wore hearing aids only and hearing aids plus FM system in a randomized fashion. The Communication Profile for the Hearing Impaired (CPHI) was administered prior to fitting the study devices and once a month for three months in each of the two conditions. A statistically significant difference between device conditions was obtained for the Importance of Communication in Work Situations subscale. Additionally, statistically significant differences over time were noted in several CPHI subscales. Despite statistical significance, none of these results were clinically significant. The implications of these results will be discussed. JF - Journal of the American Academy of Audiology AU - Lewis, M Samantha AU - Valente, Michael AU - Horn, Jane Enrietto AU - Crandell, Carl AD - University of Florida, National Center for Rehabilitative Auditory Research, Portland VA Medical Center, USA. Michele.Lewis3@med.va.gov Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - 250 EP - 261 VL - 16 IS - 4 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Aged, 80 and over KW - Analysis of Variance KW - Auditory Threshold KW - *Communication KW - Ear, Middle KW - Female KW - *Hearing Aids KW - *Hearing Impaired Persons: rehabilitation KW - Humans KW - Male KW - Rehabilitation of Hearing Impaired KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85387356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=The+effect+of+hearing+aids+and+frequency+modulation+technology+on+results+from+the+communication+profile+for+the+hearing+impaired.&rft.au=Lewis%2C+M+Samantha%3BValente%2C+Michael%3BHorn%2C+Jane+Enrietto%3BCrandell%2C+Carl&rft.aulast=Lewis&rft.aufirst=M&rft.date=2005-04-01&rft.volume=16&rft.issue=4&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Dysplasia and risk of further neoplastic progression in a regional Veterans Administration Barrett's cohort. AN - 85380904; pmid-15784018 AB - No published data are available on the risk of further neoplastic progression in Barrett's patients stratified by baseline dysplasia status. Our aims were to estimate and compare the risk of progression to high-grade dysplasia or cancer in groups of Barrett's patients stratified by baseline dysplasia status.Consecutive Barrett's cases from 1988-2002 were identified via pathology databases in a regional VA health-care system and medical record data were abstracted. The risk of progression to high-grade dysplasia or cancer was measured and compared in cases with versus without low-grade dysplasia within 1 yr of index endoscopy using survival analysis.A total of 575 Barrett's cases had 2,775 patient-years of follow-up. There were 13 incident cases of high-grade dysplasia and two of cancer. The crude rate of high-grade dysplasia or cancer was 1 of 78 patient-years for those with baseline dysplasia versus 1 of 278 patient-years for those without (p= 0.001). One case of high-grade dysplasia in each group underwent successful therapy. One incident cancer case underwent successful resection and the other was unresectable. Two cases with high-grade dysplasia later developed cancer, one died postoperatively, the other was unresectable. When these two cases were included (total of four cancers), the crude rate of cancer was 1 of 274 patient-years for those with baseline dysplasia versus 1 of 1,114 patient-years for those without.In a large cohort study of Barrett's, incident malignancy was uncommon. The rate of progression to high-grade dysplasia or cancer was significantly higher in those with baseline low-grade dysplasia. These data may warrant reevaluation of current Barrett's surveillance strategies. JF - The American journal of gastroenterology AU - Dulai, Gareth S AU - Shekelle, Paul G AU - Jensen, Dennis M AU - Spiegel, Brennan M R AU - Chen, Jaime AU - Oh, David AU - Kahn, Katherine L AD - Greater Los Angeles Veterans Administration Healthcare System, Department of Medicine, Division of Gastroenterology, UCLA School of Medicine, Los Angeles, CA 90073, USA. Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - 775 EP - 783 VL - 100 IS - 4 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - *Adenocarcinoma: epidemiology KW - Adenocarcinoma: pathology KW - Aged KW - *Barrett Esophagus: epidemiology KW - Barrett Esophagus: pathology KW - Biopsy KW - California: epidemiology KW - *Cell Transformation, Neoplastic: pathology KW - Cohort Studies KW - Cross-Sectional Studies KW - Data Collection: statistics & numerical data KW - Delivery of Health Care, Integrated: statistics & numerical data KW - Disease Progression KW - *Esophageal Neoplasms: epidemiology KW - Esophageal Neoplasms: pathology KW - Esophagoscopy KW - Esophagus: pathology KW - Follow-Up Studies KW - Hospitals, Veterans: statistics & numerical data KW - Humans KW - Incidence KW - Male KW - Medical Records Systems, Computerized: statistics & numerical data KW - Metaplasia KW - Middle Aged KW - Population Surveillance KW - *Precancerous Conditions: epidemiology KW - Precancerous Conditions: pathology KW - Risk Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85380904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Dysplasia+and+risk+of+further+neoplastic+progression+in+a+regional+Veterans+Administration+Barrett%27s+cohort.&rft.au=Dulai%2C+Gareth+S%3BShekelle%2C+Paul+G%3BJensen%2C+Dennis+M%3BSpiegel%2C+Brennan+M+R%3BChen%2C+Jaime%3BOh%2C+David%3BKahn%2C+Katherine+L&rft.aulast=Dulai&rft.aufirst=Gareth&rft.date=2005-04-01&rft.volume=100&rft.issue=4&rft.spage=775&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Reduced CFTR function and the pathobiology of idiopathic pancreatitis. AN - 85379772; pmid-15758663 AB - Idiopathic chronic pancreatitis (ICP) is the leading cause of chronic pancreatitis in children and nonalcoholic adults. The risk of developing ICP is increased in individuals who have mutations of the cystic fibrosis gene (CFTR) and of a trypsin inhibitor gene (PSTI). In studies from the United States and France, the risk of ICP is increased about 40-fold by having two abnormal copies of the CFTR gene, about 14-fold by having the N34S PSTI mutation, and about 500-fold by having both. When ICP patients have two abnormal copies of the CFTR gene, there is also evidence of reduced residual CFTR protein function in extrapancreatic tissues based on clinical findings and nasal ion transport responses. Thus, pancreatitis risk is highest in individuals who have abnormalities in both the pancreatic ducts (CFTR) and acini (PSTI). These findings indicate that PSTI is a modifier gene for CFTR-related ICP and have implications for the diagnosis and pathogenesis of pancreatitis. JF - Journal of clinical gastroenterology AU - Cohn, Jonathan A AD - Veterans Administration and Duke University Medical Centers, Durham, NC 27710, USA. cohn0001@mc.duke.edu Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - S70 EP - S77 VL - 39 IS - 4 Suppl 2 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Child KW - Chronic Disease KW - Cystic Fibrosis: genetics KW - *Cystic Fibrosis Transmembrane Conductance Regulator: genetics KW - Genotype KW - Humans KW - Mutation KW - Pancreatitis: classification KW - *Pancreatitis: genetics KW - Prevalence KW - Trypsin Inhibitors: genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85379772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Reduced+CFTR+function+and+the+pathobiology+of+idiopathic+pancreatitis.&rft.au=Cohn%2C+Jonathan+A&rft.aulast=Cohn&rft.aufirst=Jonathan&rft.date=2005-04-01&rft.volume=39&rft.issue=4+Suppl+2&rft.spage=S70&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Portal hypertension: from bedside to bench. AN - 85378717; pmid-15758647 AB - The initial factor leading to portal hypertension is an increase in hepatic resistance. Later, an increase in portal blood flow contributes to maintain and exacerbate portal hypertension despite the development of portosystemic collaterals. The critical step in the development and acceptance of these concepts, which proved crucial for the management of patients with portal hypertension, was the development of animal models. These allowed the full characterization of the profound hemodynamic abnormalities in the systemic and splanchnic circulation associated with portal hypertension, and the elucidation of the molecular mechanisms implicated in these disturbances. This review traces how seminal clinical observations in the 1950s raised meaningful questions that were subsequently answered at the bench, leading to our current understanding of the pathophysiology of portal hypertension and of the pathogenesis of severe complications of cirrhosis, such as variceal bleeding or ascites. JF - Journal of clinical gastroenterology AU - Groszmann, Roberto J AU - Abraldes, Juan G AD - Veterans Administration Medical Center, West Haven, CT 06516, USA. roberto.groszmann@yale.edu Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - S125 EP - S130 VL - 39 IS - 4 Suppl 2 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Hemodynamics: physiology KW - Humans KW - *Hypertension, Portal: etiology KW - Hypertension, Portal: physiopathology KW - Liver Circulation: physiology KW - Liver Cirrhosis: physiopathology KW - Nitric Oxide: physiology KW - Portal System: physiology KW - Splanchnic Circulation: physiology KW - Vascular Resistance: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85378717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Portal+hypertension%3A+from+bedside+to+bench.&rft.au=Groszmann%2C+Roberto+J%3BAbraldes%2C+Juan+G&rft.aulast=Groszmann&rft.aufirst=Roberto&rft.date=2005-04-01&rft.volume=39&rft.issue=4+Suppl+2&rft.spage=S125&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Colchicine treatment of alcoholic cirrhosis: a randomized, placebo-controlled clinical trial of patient survival. AN - 67728831; 15825072 AB - Colchicine improved survival and reversed cirrhosis in several small clinical trials. We compared the efficacy and safety of long-term colchicine, as compared with placebo, in patients with advanced alcoholic cirrhosis. Five hundred forty-nine patients with advanced (Pugh B or C) alcoholic cirrhosis were randomized to receive either colchicine 0.6 mg twice per day (n = 274) or placebo (n = 275). Treatment lasted from 2 to 6 years. The primary outcome was all-cause mortality. Secondary outcomes were liver-related morbidity and mortality. Liver biopsy was requested prior to entry and after 24 months of treatment. Attendance at scheduled clinic visits and adherence with study medication were similar in colchicine and placebo groups. Alcohol intake was less than 1 drink per day in 69% of patients. In an intention-to-treat analysis, all-cause mortality was similar in colchicine (49%) and placebo (45%) patients (P = .371). Mortality attributed to liver disease was 32% in colchicine and 28% in placebo patients (P = .337). Fewer patients receiving colchicine developed hepatorenal syndrome. In 54 patients with repeat liver biopsies after 24 or more months of treatment, cirrhosis improved to septal fibrosis in 7 patients (3 colchicine, 4 placebo) and to portal fibrosis in 1 patient (colchicine). In patients with advanced alcoholic cirrhosis, colchicine does not reduce overall or liver-specific mortality. Liver histology improves to septal fibrosis in a minority of patients after 24 months of treatment, with similar rates of improvement in patients receiving placebo and colchicine. Colchicine is not recommended for patients with advanced alcoholic cirrhosis. JF - Gastroenterology AU - Morgan, Timothy R AU - Weiss, David G AU - Nemchausky, Bernard AU - Schiff, Eugene R AU - Anand, Bhupinder AU - Simon, Francis AU - Kidao, Jayashri AU - Cecil, Bennet AU - Mendenhall, Charles L AU - Nelson, Douglas AU - Lieber, Charles AU - Pedrosa, Marcos AU - Jeffers, Lennox AU - Bloor, John AU - Lumeng, Lawrence AU - Marsano, Luis AU - McClain, Craig AU - Mishra, Girish AU - Myers, Brent AU - Leo, Maria AU - Ponomarenko, Yelena AU - Taylor, Derek AU - Chedid, Antonio AU - French, Samuel AU - Kanel, Gary AU - Murray, Natalie AU - Pinto, Paul AU - Fong, Tse-Ling AU - Sather, Mike R AD - VA Long Beach Healthcare Systems, Long Beach, CA 90822, USA. timothy.morgan@med.va.gov Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 882 EP - 890 VL - 128 IS - 4 SN - 0016-5085, 0016-5085 KW - Colchicine KW - SML2Y3J35T KW - Abridged Index Medicus KW - Index Medicus KW - Treatment Failure KW - Liver -- pathology KW - Double-Blind Method KW - Liver -- drug effects KW - Humans KW - Middle Aged KW - Morbidity KW - Male KW - Female KW - Survival Analysis KW - Liver Cirrhosis, Alcoholic -- pathology KW - Liver Cirrhosis, Alcoholic -- mortality KW - Colchicine -- therapeutic use KW - Liver Cirrhosis, Alcoholic -- epidemiology KW - Liver Cirrhosis, Alcoholic -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67728831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Colchicine+treatment+of+alcoholic+cirrhosis%3A+a+randomized%2C+placebo-controlled+clinical+trial+of+patient+survival.&rft.au=Morgan%2C+Timothy+R%3BWeiss%2C+David+G%3BNemchausky%2C+Bernard%3BSchiff%2C+Eugene+R%3BAnand%2C+Bhupinder%3BSimon%2C+Francis%3BKidao%2C+Jayashri%3BCecil%2C+Bennet%3BMendenhall%2C+Charles+L%3BNelson%2C+Douglas%3BLieber%2C+Charles%3BPedrosa%2C+Marcos%3BJeffers%2C+Lennox%3BBloor%2C+John%3BLumeng%2C+Lawrence%3BMarsano%2C+Luis%3BMcClain%2C+Craig%3BMishra%2C+Girish%3BMyers%2C+Brent%3BLeo%2C+Maria%3BPonomarenko%2C+Yelena%3BTaylor%2C+Derek%3BChedid%2C+Antonio%3BFrench%2C+Samuel%3BKanel%2C+Gary%3BMurray%2C+Natalie%3BPinto%2C+Paul%3BFong%2C+Tse-Ling%3BSather%2C+Mike+R&rft.aulast=Morgan&rft.aufirst=Timothy&rft.date=2005-04-01&rft.volume=128&rft.issue=4&rft.spage=882&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-12 N1 - Date created - 2005-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Helicobacter pylori VacA, a paradigm for toxin multifunctionality. AN - 67704125; 15759043 AB - Bacterial protein toxins alter eukaryotic cellular processes and enable bacteria to successfully colonize their hosts. In recent years, there has been increased recognition that many bacterial toxins are multifunctional proteins that can have pleiotropic effects on mammalian cells and tissues. In this review, we examine a multifunctional toxin (VacA) that is produced by the bacterium Helicobacter pylori. The actions of H. pylori VacA represent a paradigm for how bacterial secreted toxins contribute to colonization and virulence in multiple ways. JF - Nature reviews. Microbiology AU - Cover, Timothy L AU - Blanke, Steven R AD - Departments of Medicine, and Microbiology and Immunology, Division of Infectious Diseases, Vanderbilt University School of Medicine and Veterans Administration Medical Center, Nashville, Tennessee 37232, USA. timothy.l.cover@vanderbilt.edu Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 320 EP - 332 VL - 3 IS - 4 SN - 1740-1526, 1740-1526 KW - Bacterial Proteins KW - 0 KW - Bacterial Toxins KW - VacA protein, Helicobacter pylori KW - Index Medicus KW - Virulence KW - Stomach Neoplasms -- microbiology KW - Antigen Presentation KW - Animals KW - Gastric Mucosa -- microbiology KW - Epithelial Cells -- physiology KW - Peptic Ulcer -- microbiology KW - T-Lymphocytes -- microbiology KW - Humans KW - Epithelial Cells -- microbiology KW - Phagocytosis KW - T-Lymphocytes -- immunology KW - Bacterial Toxins -- genetics KW - Bacterial Proteins -- genetics KW - Bacterial Proteins -- chemistry KW - Helicobacter Infections -- microbiology KW - Bacterial Toxins -- chemistry KW - Helicobacter pylori -- pathogenicity KW - Bacterial Toxins -- toxicity KW - Helicobacter pylori -- growth & development KW - Bacterial Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67704125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+reviews.+Microbiology&rft.atitle=Helicobacter+pylori+VacA%2C+a+paradigm+for+toxin+multifunctionality.&rft.au=Cover%2C+Timothy+L%3BBlanke%2C+Steven+R&rft.aulast=Cover&rft.aufirst=Timothy&rft.date=2005-04-01&rft.volume=3&rft.issue=4&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Microbiology&rft.issn=17401526&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-28 N1 - Date created - 2005-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Divalproex in the treatment of bipolar depression: a placebo-controlled study. AN - 67538568; 15780695 AB - The treatment of bipolar disorder in the depressed phase is complicated by a tendency for conventional antidepressant drugs to worsen the course of the illness by precipitating a manic episode or increasing cycle frequency. Thus, the potential antidepressant efficacy of mood stabilizers, such as divalproex, which is an effective treatment for the manic phase of bipolar disorder, is of considerable interest. The clinical efficacy of divalproex (valproate, Depakote) was tested in an 8-week, double-blind, placebo-controlled, randomized clinical trial in 25 outpatients with bipolar I depression. The primary outcome measure was the 17-item Hamilton Rating Scale for Depression, and secondary measures included the Hamilton Rating Scale for Anxiety, the Clinician Administered Rating Scale for Mania, and the Clinical Global Impression scale. Using repeated measures ANOVA with last observation carried forward, divalproex was more effective than placebo in improving symptoms of depression (p = 0.0002) and symptoms of anxiety (p = 0.0001) than placebo. The sample size was small, and most patients were male. These pilot results indicate that divalproex is effective in reducing the symptoms of depression and anxiety in bipolar I, depressed phase. These positive results support the need to perform a larger, multisite study of divalproex treatment for bipolar depression. JF - Journal of affective disorders AU - Davis, Lori L AU - Bartolucci, Al AU - Petty, Frederick AD - Veteran's Affairs Medical Center (151), 3701 Loop Road East, Tuscaloosa, AL 35404, USA. lori.davis@med.va.gov Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 259 EP - 266 VL - 85 IS - 3 SN - 0165-0327, 0165-0327 KW - Anticonvulsants KW - 0 KW - Antimanic Agents KW - Valproic Acid KW - 614OI1Z5WI KW - Index Medicus KW - Anxiety -- psychology KW - Double-Blind Method KW - Humans KW - Anxiety -- drug therapy KW - Personality Inventory KW - Ambulatory Care KW - Anxiety -- diagnosis KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Personality Assessment KW - Female KW - Male KW - Bipolar Disorder -- diagnosis KW - Bipolar Disorder -- drug therapy KW - Antimanic Agents -- adverse effects KW - Anticonvulsants -- adverse effects KW - Bipolar Disorder -- psychology KW - Antimanic Agents -- therapeutic use KW - Valproic Acid -- adverse effects KW - Valproic Acid -- therapeutic use KW - Anticonvulsants -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67538568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+affective+disorders&rft.atitle=Divalproex+in+the+treatment+of+bipolar+depression%3A+a+placebo-controlled+study.&rft.au=Davis%2C+Lori+L%3BBartolucci%2C+Al%3BPetty%2C+Frederick&rft.aulast=Davis&rft.aufirst=Lori&rft.date=2005-04-01&rft.volume=85&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Journal+of+affective+disorders&rft.issn=01650327&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-09 N1 - Date created - 2005-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence and distinct correlates of anxiety, substance, and combined comorbidity in a multi-site public sector sample with bipolar disorder. AN - 67538193; 15780700 AB - Recent data indicate high prevalence of both anxiety and substance comorbidity in bipolar disorder. However, few studies have utilized public sector samples, and only one has attempted to separate contributions of each type of comorbidity. 328 inpatient veterans with bipolar disorder across 11 sites were assessed using selected Structured Clinical Interview for DSM-IV modules and self-reports. Comorbidity was common (current: 57.3%; lifetime: 78.4%), with multiple current comorbidities in 29.8%. Substance comorbidity rate was comparable to rates typically reported in non-veteran inpatient samples (33.8% current, 72.3% lifetime). Selected anxiety comorbidity rates exceeded those in other inpatient samples and appeared more chronic than episodic/recurrent (38.3% current, 43.3% lifetime). 49% of PTSD was due to non-combat stressors. Major correlates of current substance comorbidity alone were younger age, worse marital status, and higher current employability. Correlates of current anxiety comorbidity alone were early age of onset, greater number of prior-year depressive episodes, higher rates of disability pension receipt, and lower self-reported mental and physical function. Combined comorbidity resembled anxiety comorbidity. This is a cross-sectional analysis of acutely hospitalized veterans. Distinct patterns of substance and anxiety comorbidity are striking, and may be subserved by distinct neurobiologic mechanisms. The prevalence, chronicity and functional impact of anxiety disorders indicate the need for improved recognition and treatment of this other dual diagnosis group is warranted. Clinical and research interventions should recognize these divergent comorbidity patterns and provide individualized treatment built "from the patient out." JF - Journal of affective disorders AU - Bauer, Mark S AU - Altshuler, Lori AU - Evans, Denise R AU - Beresford, Thomas AU - Williford, William O AU - Hauger, Richard AU - VA Cooperative Study #430 Team AD - VAMC and Brown University, 116R, 830 Chalkstone Avenue, Providence, RI 02908-4799, USA. mark.bauer@med.va.gov ; VA Cooperative Study #430 Team Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 301 EP - 315 VL - 85 IS - 3 SN - 0165-0327, 0165-0327 KW - Index Medicus KW - Public Sector KW - Humans KW - Aged KW - Combat Disorders -- epidemiology KW - Hospitals, Veterans -- statistics & numerical data KW - Comorbidity KW - Health Services Accessibility -- statistics & numerical data KW - California KW - Cross-Sectional Studies KW - Combat Disorders -- psychology KW - Pensions KW - Ambulatory Care -- statistics & numerical data KW - Adult KW - Combat Disorders -- diagnosis KW - Disability Evaluation KW - Middle Aged KW - Statistics as Topic KW - Personality Assessment KW - Hospitalization -- statistics & numerical data KW - Male KW - Female KW - Bipolar Disorder -- diagnosis KW - Alcoholism -- diagnosis KW - Anxiety Disorders -- psychology KW - Anxiety Disorders -- diagnosis KW - Veterans -- psychology KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Substance-Related Disorders -- diagnosis KW - Bipolar Disorder -- epidemiology KW - Veterans -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Bipolar Disorder -- psychology KW - Anxiety Disorders -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67538193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+affective+disorders&rft.atitle=Prevalence+and+distinct+correlates+of+anxiety%2C+substance%2C+and+combined+comorbidity+in+a+multi-site+public+sector+sample+with+bipolar+disorder.&rft.au=Bauer%2C+Mark+S%3BAltshuler%2C+Lori%3BEvans%2C+Denise+R%3BBeresford%2C+Thomas%3BWilliford%2C+William+O%3BHauger%2C+Richard%3B430+Team&rft.aulast=Bauer&rft.aufirst=Mark&rft.date=2005-04-01&rft.volume=85&rft.issue=3&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Journal+of+affective+disorders&rft.issn=01650327&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-09 N1 - Date created - 2005-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acrylonitrile potentiates hearing loss and cochlear damage induced by moderate noise exposure in rats. AN - 67535805; 15781293 AB - The diversity of chemical and drugs that can potentiate noise-induced hearing loss (NIHL) has impeded efforts to predict such interactions. We have hypothesized that chemical contaminants that disrupt intrinsic antioxidant defenses hold significant risk for potentiating NIHL. If this is true, then acrylonitrile (ACN) would be expected to potentiate NIHL. ACN, one of the 50 most commonly used chemicals in the United States, is metabolized via two pathways that are likely to disrupt intrinsic reactive oxygen species (ROS) buffering systems: (1) it conjugates glutathione, depleting this important antioxidant rapidly; (2) a second pathway involves the formation of cyanide, which can inhibit superoxide dismutase. We hypothesized that moderate noise exposure, that does not produce permanent hearing loss by itself, could initiate oxidative stress and that ACN could render the inner ear more sensitive to noise by disrupting intrinsic antioxidant defenses. Temporary and persistent effects of ACN alone (50 mg/kg, sc 5 days), noise alone (95 or 97 dB octave band noise, 4 h/day for 5 days), or ACN in combination with noise were determined using distortion product otoacoustic emissions (DPOAEs) and compound action potential (CAP) amplitudes. Histopathological damage to hair cells resulting from these treatments was also investigated using surface preparations of the organ of Corti. Individually, neither ACN nor noise exposures caused any permanent hearing or hair cell loss; only a reversible temporary threshold shift was measured in noise-exposed animals. However, when given in combination, ACN and noise induced permanent threshold shifts (13-16 dB between 7 and 40 kHz) and a decrease in DPOAE amplitudes (up to 25 dB at 19 kHz), as well as significant outer hair cell (OHC) loss (up to 20% in the first row between 13 and 47 kHz). This investigation demonstrates that ACN can potentiate NIHL at noise levels that are realistic in terms of human exposure, and that the OHCs are the main target of toxicity. While the exact mechanism is unknown, the results are consistent with the hypothesis of ROS involvement in NIHL at moderate levels. JF - Toxicology and applied pharmacology AU - Pouyatos, Benoît AU - Gearhart, Caroline A AU - Fechter, Laurence D AD - Jerry Pettis Memorial Veterans Medical Center, Research Service (151), 11201 Benton Street, Loma Linda, CA 92357, USA. benoit.pouyatos@med.va.gov Y1 - 2005/04/01/ PY - 2005 DA - 2005 Apr 01 SP - 46 EP - 56 VL - 204 IS - 1 SN - 0041-008X, 0041-008X KW - Acrylonitrile KW - MP1U0D42PE KW - Index Medicus KW - Rats KW - Animals KW - Rats, Long-Evans KW - Otoacoustic Emissions, Spontaneous KW - Auditory Threshold -- drug effects KW - Action Potentials -- drug effects KW - Male KW - Hearing Loss, Noise-Induced -- physiopathology KW - Hair Cells, Auditory, Outer -- physiopathology KW - Acrylonitrile -- toxicity KW - Hair Cells, Auditory, Outer -- drug effects KW - Hair Cells, Auditory, Outer -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67535805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Acrylonitrile+potentiates+hearing+loss+and+cochlear+damage+induced+by+moderate+noise+exposure+in+rats.&rft.au=Pouyatos%2C+Beno%C3%AEt%3BGearhart%2C+Caroline+A%3BFechter%2C+Laurence+D&rft.aulast=Pouyatos&rft.aufirst=Beno%C3%AEt&rft.date=2005-04-01&rft.volume=204&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-31 N1 - Date created - 2005-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Overexpression of vascular endothelial growth factor and its receptors in bronchial dypslasia demonstrated by quantitative RT-PCR analysis. AN - 67532499; 15777969 AB - Neoangiogenesis is required for the growth of invasive lung carcinoma, however, the role of angiogenesis in the progression of premalignant changes to carcinoma of the lung is less clear. We have evaluated vascular endothelial growth factor (VEGF) expression and microvessel densities (MVDs) in 62 bronchoscopic biopsies from normal, reactive (basal cell hyperplasia (BCH)) and dysplastic bronchial epithelium and in tissue from twenty-seven invasive lung carcinomas in an effort to demonstrate angiogenic activity in these preneoplastic lesions and determine whether it is associated with increased bronchial epithelial VEGF expression. MVDs and VEGF RNA expression measured by quantitative RT-PCR were found to be elevated in comparison to normal bronchial tissue in bronchial dysplasias and invasive lung carcinomas but not in basal cell hyperplasias. Immunohistochemical (IHC) analyses revealed that expression of VEGF arose predominantly from bronchial epithelium. ELISA analysis of lung tumor tissue showed that elevated VEGF protein expression correlated with VEGF RNA levels (r=0.59, p=0.004). Increased expression of VEGF RNA was also found in histologically normal bronchial mucosa from patients with either dysplasia at other sites or a history of heavy tobacco use suggesting a possible field effect in regard to the elaboration of VEGF. Furthermore, analysis of VEGF isoforms and VEGF receptors by semi-quantitative RT-PCR in dysplastic and invasive lesions revealed characteristic altered patterns of expression in dysplasia and early cancer as compared to normal tissue. These results indicate that angiogenesis develops early in lung carcinogenesis and is associated with overexpression of VEGF. JF - Lung cancer (Amsterdam, Netherlands) AU - Merrick, Daniel T AU - Haney, Jerry AU - Petrunich, Sheila AU - Sugita, Michio AU - Miller, York E AU - Keith, Robert L AU - Kennedy, Tim C AU - Franklin, Wilbur A AD - Department of Pathology, Denver Veteran's Affairs Medical Center, 1055 Clermont St., Denver, CO 80220, USA. Daniel.Merrick@med.va.gov Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 31 EP - 45 VL - 48 IS - 1 SN - 0169-5002, 0169-5002 KW - Vascular Endothelial Growth Factor A KW - 0 KW - RNA KW - 63231-63-0 KW - Receptors, Vascular Endothelial Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Neoplasm Invasiveness KW - Receptors, Vascular Endothelial Growth Factor -- metabolism KW - Humans KW - Receptors, Vascular Endothelial Growth Factor -- genetics KW - Receptors, Vascular Endothelial Growth Factor -- biosynthesis KW - Disease Progression KW - Smoking -- adverse effects KW - Enzyme-Linked Immunosorbent Assay KW - Biopsy KW - Up-Regulation KW - Reverse Transcriptase Polymerase Chain Reaction KW - Immunohistochemistry KW - RNA -- biosynthesis KW - Gene Expression Profiling KW - Vascular Endothelial Growth Factor A -- biosynthesis KW - Precancerous Conditions -- genetics KW - Precancerous Conditions -- blood supply KW - Lung Neoplasms -- blood supply KW - Lung Neoplasms -- genetics KW - Neovascularization, Pathologic KW - Vascular Endothelial Growth Factor A -- genetics KW - Precancerous Conditions -- pathology KW - Vascular Endothelial Growth Factor A -- metabolism KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67532499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lung+cancer+%28Amsterdam%2C+Netherlands%29&rft.atitle=Overexpression+of+vascular+endothelial+growth+factor+and+its+receptors+in+bronchial+dypslasia+demonstrated+by+quantitative+RT-PCR+analysis.&rft.au=Merrick%2C+Daniel+T%3BHaney%2C+Jerry%3BPetrunich%2C+Sheila%3BSugita%2C+Michio%3BMiller%2C+York+E%3BKeith%2C+Robert+L%3BKennedy%2C+Tim+C%3BFranklin%2C+Wilbur+A&rft.aulast=Merrick&rft.aufirst=Daniel&rft.date=2005-04-01&rft.volume=48&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Lung+cancer+%28Amsterdam%2C+Netherlands%29&rft.issn=01695002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-12 N1 - Date created - 2005-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Low-dose fluvoxamine as an adjunct to reduce olanzapine therapeutic dose requirements: a prospective dose-adjusted drug interaction strategy. AN - 67474409; 15738749 AB - Despite the advances in antipsychotic pharmacotherapy over the past decade, many atypical antipsychotic agents are not readily accessible by patients with major psychosis or in developing countries where the acquisition costs may be prohibitive. Olanzapine is an efficacious and widely prescribed atypical antipsychotic agent. In theory, olanzapine therapeutic dose requirement may be reduced during concurrent treatment with inhibitors of drug metabolism. In vitro studies suggest that smoking-inducible cytochrome P450 (CYP) 1A2 contributes to formation of the metabolite 4'-N-desmethylolanzapine. The present prospective study tested the hypothesis that olanzapine steady-state doses can be significantly decreased by coadministration of a low subclinical dose of fluvoxamine, a potent inhibitor of cytochrome P450 1A2. The study design followed a targeted "at-risk" population approach with a focus on smokers who were likely to exhibit increased cytochrome P450 1A2 expression. Patients with stable psychotic illness (N = 10 men, all smokers) and receiving chronic olanzapine treatment were evaluated for steady-state plasma concentrations of olanzapine and 4'-N-desmethylolanzapine. Subsequently, olanzapine dose was reduced from 17.5 +/- 4.2 mg/d (mean +/- SD) to 13.0 +/- 3.3 mg/d, and a nontherapeutic dose of fluvoxamine (25 mg/d, PO) was added to regimen. Patients were reevaluated at 2, 4, and 6 weeks during olanzapine-fluvoxamine cotreatment. There was no significant change in olanzapine plasma concentration, antipsychotic response, or metabolic indices (eg, serum glucose and lipids) after dose reduction in the presence of fluvoxamine (P > 0.05). 4'-N-desmethylolanzapine/olanzapine metabolic ratio decreased from 0.45 +/- 0.20 at baseline to 0.25 +/- 0.11 at week 6, suggesting inhibition of the cytochrome P450 1A2-mediated olanzapine 4'-N-demethylation by fluvoxamine (P < 0.05). In conclusion, this prospective pilot study suggests that a 26% reduction in olanzapine therapeutic dose requirement may be achieved by coadministration of a nontherapeutic oral dose of fluvoxamine. JF - Journal of clinical psychopharmacology AU - Albers, Lawrence J AU - Ozdemir, Vural AU - Marder, Stephen R AU - Raggi, Maria Augusta AU - Aravagiri, Manickam AU - Endrenyi, Laszlo AU - Reist, Christopher AD - VA Long Beach Healthcare System, Department of Psychiatry and Human Behavior, College of Medicine, University of California Irvine, CA 90822, USA. larry.albers@med.va.gov Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 170 EP - 174 VL - 25 IS - 2 SN - 0271-0749, 0271-0749 KW - Benzodiazepines KW - 12794-10-4 KW - olanzapine KW - N7U69T4SZR KW - Fluvoxamine KW - O4L1XPO44W KW - Index Medicus KW - Drug Therapy, Combination KW - Prospective Studies KW - Humans KW - Pilot Projects KW - Middle Aged KW - Drug Interactions -- physiology KW - Psychotic Disorders -- blood KW - Benzodiazepines -- blood KW - Fluvoxamine -- blood KW - Benzodiazepines -- administration & dosage KW - Psychotic Disorders -- drug therapy KW - Fluvoxamine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67474409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Low-dose+fluvoxamine+as+an+adjunct+to+reduce+olanzapine+therapeutic+dose+requirements%3A+a+prospective+dose-adjusted+drug+interaction+strategy.&rft.au=Albers%2C+Lawrence+J%3BOzdemir%2C+Vural%3BMarder%2C+Stephen+R%3BRaggi%2C+Maria+Augusta%3BAravagiri%2C+Manickam%3BEndrenyi%2C+Laszlo%3BReist%2C+Christopher&rft.aulast=Albers&rft.aufirst=Lawrence&rft.date=2005-04-01&rft.volume=25&rft.issue=2&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-15 N1 - Date created - 2005-03-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Psychopharmacol. 2005 Dec;25(6):626-7; author reply 627-8 [16282861] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Art of Prescribing. Mitigating Cognitive Side Effects Associated with Topiramate AN - 20236778; 6618706 JF - Perspectives in Psychiatric Care AU - Antai-Otong, Deborah Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - 92 EP - 93 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 41 IS - 2 SN - 0031-5990, 0031-5990 KW - Toxicology Abstracts KW - Cognitive ability KW - topiramate KW - Side effects KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20236778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+in+Psychiatric+Care&rft.atitle=The+Art+of+Prescribing.+Mitigating+Cognitive+Side+Effects+Associated+with+Topiramate&rft.au=Antai-Otong%2C+Deborah&rft.aulast=Antai-Otong&rft.aufirst=Deborah&rft.date=2005-04-01&rft.volume=41&rft.issue=2&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Perspectives+in+Psychiatric+Care&rft.issn=00315990&rft_id=info:doi/10.1111%2Fj.1744-6163.2005.00018.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - SuppNotes - References, 16. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cognitive ability; topiramate; Side effects DO - http://dx.doi.org/10.1111/j.1744-6163.2005.00018.x ER - TY - JOUR T1 - Cigarettes, alcohol, and depression: Characterizing head and neck cancer survivors in two systems of care AN - 17649701; 6469058 AB - Tobacco exposure is a key risk factor for head and neck cancer, and continued smoking after diagnosis negatively affects outcomes. The present study examined tobacco smoking, nicotine dependence, alcohol use, and depression in survivors of head and neck cancer. Subjects at least 6 months post-initial diagnosis of head and neck cancer (N = 694) drawn from three VA otolaryngology clinics (n = 309, VA patients) and a university-based otolaryngology clinic (n = 385, non-VA patients) were administered questionnaires and standardized rating instruments for nicotine and alcohol dependence and for depression. Additional clinical information was extracted from chart reviews. Despite high rates of prior smoking, less than one-quarter of all subjects continued to smoke. After controlling for significant confounding variables, we found that VA patients were more likely to be current smokers (OR = 1.9, 95% CI = 1.3-3.0), but current VA smokers did not differ significantly from non-VA smokers on the Fagerstroem Test for Nicotine Dependence criterion (p = .69). The VA patients were more likely to screen positive for problem drinking on the Alcohol Use Disorder Identification Test (OR = 2.1, 95% CI = 1.3-3.7). After adjusting for other variables, we found no statistical difference between the groups in depression scores on the Geriatric Depression Scale-Short Form. The study provides data on smoking, alcohol use, and depression in head and neck cancer survivors indicating that VA patients are at increased risk for continued smoking and problem drinking relative to non-VA patients. Head and neck cancer patients benefit from aggressive smoking cessation efforts by the VA, but many patients need specialized services that integrate smoking interventions with treatment of comorbid alcoholism. JF - Nicotine & Tobacco Research AU - Lambert, M T AU - Terrell, JE AU - Copeland, LA AU - Ronis, D L AU - Duffy, SA AD - Fort Worth VA Mental Health Clinic, 6000 Western Place, Suite 300, Fort Worth, TX 76107-4607, USA, michael.lambert2@med.va.gov Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - 233 EP - 241 VL - 7 IS - 2 SN - 1462-2203, 1462-2203 KW - Toxicology Abstracts KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17649701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+Tobacco+Research&rft.atitle=Cigarettes%2C+alcohol%2C+and+depression%3A+Characterizing+head+and+neck+cancer+survivors+in+two+systems+of+care&rft.au=Lambert%2C+M+T%3BTerrell%2C+JE%3BCopeland%2C+LA%3BRonis%2C+D+L%3BDuffy%2C+SA&rft.aulast=Lambert&rft.aufirst=M&rft.date=2005-04-01&rft.volume=7&rft.issue=2&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+Tobacco+Research&rft.issn=14622203&rft_id=info:doi/10.1080%2F14622200500055418 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-10-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1080/14622200500055418 ER - TY - JOUR T1 - Experimentally induced pain perception is acutely reduced by aerobic exercise in people with chronic low back pain AN - 17361834; 6433700 AB - This study examined whether subjects with chronic low back pain demonstrate exercise-induced analgesia to experimentally induced pressure pain. We employed a repeated measures design to study eight subjects with chronic low back pain (mean +/- standard deviation age = 40 +/- 10, duration of pain = 7 +/- 4 years). Pain ratings were measured immediately before and 2 minutes and 32 minutes after 25 minutes of cycle ergometry (5 minutes at 50% peak oxygen uptake, then 20 minutes at 70% peak oxygen uptake). We based the pain ratings on subject input on a visual analog scale at 10-second intervals during the 2-minute pressure pain stimulus to the non-dominant index finger. Compared with preexercise values, pain ratings were significantly (p < 0.05) decreased after exercise at both 2 and 32 minutes postexercise. We conclude that pressure pain perception can be reduced for more than 30 minutes following aerobic exercise from leg cycling among people with chronic low back pain. JF - Journal of Rehabilitation Research and Development AU - Hoffman, MD AU - Shepanski, MA AU - MacKenzie, S P AU - Clifford, P S AD - Department of Physical Medicine and Rehabilitation (117), Sacramento VA Medical Center, 10535 Hospital Way, Mather, CA 95655-1200, USA, martin.hoffman@med.va.gov Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - 183 EP - 190 VL - 42 IS - 2 SN - 0748-7711, 0748-7711 KW - Physical Education Index KW - Fingers KW - Measurement KW - Research (statistical design) KW - Perception KW - Ergometry KW - Stress KW - Pain KW - Legs KW - Exercise (programs) KW - Backache KW - PE 110:Physical Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17361834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Experimentally+induced+pain+perception+is+acutely+reduced+by+aerobic+exercise+in+people+with+chronic+low+back+pain&rft.au=Hoffman%2C+MD%3BShepanski%2C+MA%3BMacKenzie%2C+S+P%3BClifford%2C+P+S&rft.aulast=Hoffman&rft.aufirst=MD&rft.date=2005-04-01&rft.volume=42&rft.issue=2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/10.1682%2FJRRD.2004.06.0065 LA - English DB - Physical Education Index N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Measurement; Fingers; Research (statistical design); Perception; Ergometry; Stress; Legs; Pain; Exercise (programs); Backache DO - http://dx.doi.org/10.1682/JRRD.2004.06.0065 ER - TY - JOUR T1 - Insulin Sensitivity Determines the Effectiveness of Dietary Macronutrient Composition on Weight Loss in Obese Women AN - 17339307; 6269913 AB - OBJECTIVE: To determine whether macronutrient composition of a hypocaloric diet can enhance its effectiveness and whether insulin sensitivity (Si) affects the response to hypocaloric diets. RESEARCH METHODS AND PROCEDURES: Obese nondiabetic insulin-sensitive (fasting insulin 15 mu U/mL; n = 9) women (23 to 53 years old) were randomized to either a high carbohydrate (CHO) (HC)/low fat (LF) (60% CHO, 20% fat) or low CHO (LC)/high fat (HF) (40% CHO, 40% fat) hypocaloric diet. Primary outcome measures after a 16-week dietary intervention were: changes in body weight (BW), Si, resting metabolic rate, and fasting lipids. RESULTS: Insulin-sensitive women on the HC/LF diet lost 13.5 plus or minus 1.2% (p < 0.001) of their initial BW, whereas those on the LC/HF diet lost 6.8 plus or minus 1.2% (p < 0.001; p < 0.002 between the groups). In contrast, among the insulin-resistant women, those on the LC/HF diet lost 13.4 plus or minus 1.3% (p < 0.001) of their initial BW as compared with 8.5 plus or minus 1.4% (p < 0.001) lost by those on the HC/LF diet (p < 0.04 between two groups). These differences could not be explained by changes in resting metabolic rate, activity, or intake. Overall, changes in Si were associated with the degree of weight loss (r = -0.57, p < 0.05). DISCUSSION: The state of Si determines the effectiveness of macronutrient composition of hypocaloric diets in obese women. For maximal benefit, the macronutrient composition of a hypocaloric diet may need to be adjusted to correspond to the state of Si. JF - Obesity Research AU - Cornier, Marc-Andre AU - Donahoo, WTroy AU - Pereira, Rocio AU - Gurevich, Inga AU - Westergren, Rickard AU - Enerback, Sven AU - Eckel, Peter J AU - Goalstone, Marc L AU - Hill, James O AU - Eckel, Robert H AU - Draznin, Boris AD - Departments of Medicine and. Pediatrics, Adult General Clinical Research Center, and the. Center for Human Nutrition, University of Colorado Health Sciences Center, Research Service of the Denver Veterans Administration Medical Center, Denver, Colorado. Medical Genetics, Department of Medical Biochemistry, Gothenburg University, Goteborg, Sweden Y1 - 2005/04// PY - 2005 DA - Apr 2005 SP - 703 EP - 709 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 13 IS - 4 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Obesity KW - Weight control KW - Lipids KW - Women KW - Diet (weight control) KW - Basal metabolic rate KW - Carbohydrates KW - Hormones KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17339307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Insulin+Sensitivity+Determines+the+Effectiveness+of+Dietary+Macronutrient+Composition+on+Weight+Loss+in+Obese+Women&rft.au=Cornier%2C+Marc-Andre%3BDonahoo%2C+WTroy%3BPereira%2C+Rocio%3BGurevich%2C+Inga%3BWestergren%2C+Rickard%3BEnerback%2C+Sven%3BEckel%2C+Peter+J%3BGoalstone%2C+Marc+L%3BHill%2C+James+O%3BEckel%2C+Robert+H%3BDraznin%2C+Boris&rft.aulast=Cornier&rft.aufirst=Marc-Andre&rft.date=2005-04-01&rft.volume=13&rft.issue=4&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Obesity; Weight control; Lipids; Women; Diet (weight control); Basal metabolic rate; Carbohydrates; Hormones ER - TY - JOUR T1 - Understanding regulation of nerve cell death by mGluRs as a method for development of successful neuroprotective strategies. AN - 67508708; 15760640 AB - A common cause of nerve cell death often leading to vascular dementia is ischemic stroke. Attempts to develop clinically effective stroke treatment and prevention strategies based on pharmacological manipulations of a single mechanism have not led to clinical success. Analysis of clinical neuroprotection trials suggests that combination treatments may be more effective. To identify optimal components for such treatment, N-methyl-d-aspartate receptor (NMDAR) activation-induced cell death in organotypic hippocampal preparations was studied as a model of neurodegeneration that occurs in association with stroke or vascular dementia. Pharmacological manipulation of metabotropic glutamate receptors mGluR1 and 5 resulted in significant reduction of nerve cell susceptibility to NMDA-induced injury, suggesting that these receptors may function as physiological regulators of neuronal vulnerability. cDNA microarray analysis of over 1000 brain-related genes performed after the neuroprotective activation of group I metabotropic glutamate receptors (mGluRs) revealed a complex pattern of activation and inactivation of seemingly unrelated genes responsible for regulation of neuronal excitability, inflammation, cell death pathways, cell adhesion and transcriptional activation. Combined pharmacological targeting of these processes may provide basis for clinical trials of effective neuroprotective compounds. JF - Journal of the neurological sciences AU - Baskys, Andrius AU - Blaabjerg, Morten AD - 06/116 VA Health Care System MIRECC, 5901 E. 7th street, Long Beach, CA 90822, USA. andrius.baskys@med.va.gov Y1 - 2005/03/15/ PY - 2005 DA - 2005 Mar 15 SP - 201 EP - 209 VL - 229-230 SN - 0022-510X, 0022-510X KW - Excitatory Amino Acids KW - 0 KW - Neuroprotective Agents KW - Receptors, Metabotropic Glutamate KW - Glutamic Acid KW - 3KX376GY7L KW - Methoxyhydroxyphenylglycol KW - 534-82-7 KW - dihydroxyphenylethylene glycol KW - CF5G2G268A KW - Index Medicus KW - Animals KW - Cell Adhesion -- physiology KW - Humans KW - Excitatory Amino Acids -- toxicity KW - Glutamic Acid -- pharmacology KW - Inflammation -- pathology KW - Methoxyhydroxyphenylglycol -- metabolism KW - Cell Death -- physiology KW - Neurons -- physiology KW - Methoxyhydroxyphenylglycol -- analogs & derivatives KW - Receptors, Metabotropic Glutamate -- physiology KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67508708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+neurological+sciences&rft.atitle=Understanding+regulation+of+nerve+cell+death+by+mGluRs+as+a+method+for+development+of+successful+neuroprotective+strategies.&rft.au=Baskys%2C+Andrius%3BBlaabjerg%2C+Morten&rft.aulast=Baskys&rft.aufirst=Andrius&rft.date=2005-03-15&rft.volume=229-230&rft.issue=&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+neurological+sciences&rft.issn=0022510X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-03 N1 - Date created - 2005-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Symptom and function change with mindfulness meditation in PTSD veterans AN - 39971792; 3921747 AU - Farr, D AU - Billig, J AU - Landes, A AU - Thuras, P Y1 - 2005/03/15/ PY - 2005 DA - 2005 Mar 15 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39971792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Symptom+and+function+change+with+mindfulness+meditation+in+PTSD+veterans&rft.au=Farr%2C+D%3BBillig%2C+J%3BLandes%2C+A%3BThuras%2C+P&rft.aulast=Farr&rft.aufirst=D&rft.date=2005-03-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ISTSS, Intl. Soc. f. Traumatic Stress Studies, 60 Revere Drive, Suite 500, Northbrook, IL 60062, USA; phone: (847) 480-9028; fax: (847) 480-9282; email: istss@istss.org; URL: www.istss.org N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy AN - 17865635; 6216410 AB - There is little systematic information regarding the immune reconstitution inflammatory syndrome (IRIS). Objective: To determine the incidence, risk factors, and long-term outcome of IRIS in HIV-infected patients receiving highly active antiretroviral therapy (HAART) who were coinfected with one of three common opportunistic pathogens. Design: A retrospective cohort identified through a city-wide prospective surveillance program. Methods: A retrospective chart review was performed for 180 HIV-infected patients who received HAART and were coinfected with Mycobacterium tuberculosis, Mycobacterium avium complex, or Cryptococcus neoformans between 1997 and 2000. Medical records were reviewed for baseline demographics, receipt and type of HAART, response to antiretroviral therapy, development of IRIS, and long-term outcome. Results: In this cohort, 31.7% of patients who received HAART developed IRIS. Patients with IRIS were more likely to have initiated HAART nearer to the time of diagnosis of their opportunistic infection (P < 0.001), to have been antiretroviral naive at time of diagnosis of their opportunistic infection (P < 0.001), and to have a more rapid initial fall in HIV-1 RNA level in response to HAART (P < 0.001). Conclusions: IRIS is common among HIV-infected persons coinfected with M. tuberculosis, M. avium complex, or C. neoformans. Antiretroviral drug-naive patients who start HAART in close proximity to the diagnosis of an opportunistic infection and have a rapid decline in HIV-1 RNA level should be monitored for development of this disorder. JF - AIDS AU - Shelburne, SA AU - Visnegarwala, F AU - Darcourt, J AU - Graviss, E A AU - Giordano, T P AU - White, AC Jr AU - Hamill, R J AD - Section of Infectious Diseases (111G), Veterans Affairs Medical Center, 2002 Holcombe Boulevard, Houston, Texas 77030-4211, USA, richard.hamill@med.va.gov Y1 - 2005/03/04/ PY - 2005 DA - 2005 Mar 04 SP - 399 EP - 406 VL - 19 IS - 4 SN - 0269-9370, 0269-9370 KW - HIV-1 KW - Risk Abstracts; Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Acquired immune deficiency syndrome KW - Mycobacterium avium KW - antiretroviral agents KW - medical records KW - Opportunist infection KW - Information systems KW - Mycobacterium tuberculosis KW - Demography KW - Cryptococcus neoformans KW - Risk factors KW - Human immunodeficiency virus 1 KW - infection KW - Tuberculosis KW - antiretroviral therapy KW - Pathogens KW - Inflammation KW - tuberculosis KW - highly active antiretroviral therapy KW - Reviews KW - Side effects KW - K 03087:Fungi: human KW - R2 23060:Medical and environmental health KW - J 02845:Ear, nose and respiratory tract KW - V 22004:AIDS: Clinical aspects KW - H 4000:Food and Drugs KW - F 06104:Virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17865635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Incidence+and+risk+factors+for+immune+reconstitution+inflammatory+syndrome+during+highly+active+antiretroviral+therapy&rft.au=Shelburne%2C+SA%3BVisnegarwala%2C+F%3BDarcourt%2C+J%3BGraviss%2C+E+A%3BGiordano%2C+T+P%3BWhite%2C+AC+Jr%3BHamill%2C+R+J&rft.aulast=Shelburne&rft.aufirst=SA&rft.date=2005-03-04&rft.volume=19&rft.issue=4&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus 1; Mycobacterium avium; Mycobacterium tuberculosis; Cryptococcus neoformans; antiretroviral agents; infection; Reviews; tuberculosis; Side effects; Acquired immune deficiency syndrome; highly active antiretroviral therapy; Opportunist infection; Inflammation; Risk factors; Tuberculosis; Information systems; medical records; Demography; antiretroviral therapy; Pathogens ER - TY - JOUR T1 - Semantic Priming in Patients with Right Frontal Lobe Lesions AN - 85631366; 200600772 AB - Patients with unilateral, right frontal lobe damage (N = 13) & matched controls (N = 20) performed a task of lexical ambiguity resolution in order to explore the contribution of right frontal regions to lexical-semantic priming. Word triplets consisting of balanced homographs were presented to participants in four conditions: concordant, discordant, neutral, & unrelated. Controls demonstrated facilitation for concordant meanings of homographs, as evidenced by their faster reaction times in the concordant relative to the unrelated (baseline) condition, as well as a lack of facilitation for the discordant meaning relative to the neutral & concordant conditions. Results in patients with right frontal lobe damage differed depending on the site of the lesion. Patients with lesions restricted to the right medial frontal lobe only showed facilitation in the neutral condition, while those with lesions encroaching upon the right dorsolateral region demonstrated facilitation of both discordant & concordant meanings relative to the baseline condition. These results support a role for the right frontal lobe in semantic priming & suggest possible specialization within the right prefrontal cortex for the processing of lexical-semantic information. 4 Tables, 1 Figure, 52 References. Adapted from the source document JF - Journal of the International Neuropsychological Society AU - McDonald, Carrie R AU - Bauer, Russell M AU - Filoteo, J Vincent AU - Grande, Laura AU - Roper, Steven N AU - Buchanan, Robert J AU - Gilmore, Robin AD - Psychology Service (116B) Delis Lab, Veterans Administration San Diego Healthcare System, La Jolla, CA camcdonald@ucsd.edu Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 132 EP - 143 VL - 11 IS - 2 SN - 1355-6177, 1355-6177 KW - Cerebral Dominance (11500) KW - Priming (67670) KW - Brain Damage (09400) KW - Brain (09350) KW - Ambiguity (01950) KW - Word Meaning (97700) KW - Homographs (32350) KW - Response Time (Psychology) (73130) KW - Semantic Processing (76760) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85631366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society&rft.atitle=Semantic+Priming+in+Patients+with+Right+Frontal+Lobe+Lesions&rft.au=McDonald%2C+Carrie+R%3BBauer%2C+Russell+M%3BFiloteo%2C+J+Vincent%3BGrande%2C+Laura%3BRoper%2C+Steven+N%3BBuchanan%2C+Robert+J%3BGilmore%2C+Robin&rft.aulast=McDonald&rft.aufirst=Carrie&rft.date=2005-03-01&rft.volume=11&rft.issue=2&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society&rft.issn=13556177&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2006-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JINSF9 N1 - SubjectsTermNotLitGenreText - Semantic Processing (76760); Brain Damage (09400); Priming (67670); Ambiguity (01950); Brain (09350); Word Meaning (97700); Homographs (32350); Response Time (Psychology) (73130); Cerebral Dominance (11500) ER - TY - JOUR T1 - Semantic Activation within and across the Cerebral Hemispheres: What's Left Isn't Right AN - 85624545; 200600788 AB - This study examined differences in the spread of semantic activation within & between the cerebral hemispheres. A lateralized lexical decision task using indirect priming was presented to 58 undergraduates with primes & targets separated by 215 or 750 milliseconds (ms). Prime & target words were presented to the same or opposite visual fields & were either directly related (book-read), indirectly related (lion-[tiger]-stripes), or unrelated (cup-street). At 215 ms, participants exhibited significant priming effects to directly related words in all conditions except when primes & targets were both presented to the right hemisphere (RH). In contrast, priming to indirectly related words was effective only when primes & targets were presented to opposite hemispheres. At 750 ms, significant priming occurred for directly related words in all conditions & for indirectly related words when primes were presented to the RH. Results suggest that priming for directly & indirectly related concepts occurs unilaterally in each hemisphere before 215 ms. Both prime types activate semantic networks in the RH within 750 ms, whereas the LH processes information in a more focused manner. This suggests that activation spreads contralaterally from each hemisphere first to directly & then to indirectly related concepts, indicating the importance of incorporating contralateral priming contrasts in lexical decision tasks. 2 Tables, 1 Appendix, 42 References. Adapted from the source document JF - Laterality: Asymmetries of Body, Brain and Cognition AU - Yochim, Brian P AU - Kender, Robert AU - Abeare, Christopher AU - Gustafson, Angela AU - Whitman, R Douglas AD - VA Northern California Health Care System, Martinez, CA Brian.Yochim@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 131 EP - 148 VL - 10 IS - 2 SN - 1357-650X, 1357-650X KW - Associative Processes (05300) KW - Priming (67670) KW - Cerebral Dominance (11500) KW - Lexical Decision Task (46645) KW - College Students (13250) KW - Semantic Fields (76710) KW - Semantic Processing (76760) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85624545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laterality%3A+Asymmetries+of+Body%2C+Brain+and+Cognition&rft.atitle=Semantic+Activation+within+and+across+the+Cerebral+Hemispheres%3A+What%27s+Left+Isn%27t+Right&rft.au=Yochim%2C+Brian+P%3BKender%2C+Robert%3BAbeare%2C+Christopher%3BGustafson%2C+Angela%3BWhitman%2C+R+Douglas&rft.aulast=Yochim&rft.aufirst=Brian&rft.date=2005-03-01&rft.volume=10&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Laterality%3A+Asymmetries+of+Body%2C+Brain+and+Cognition&rft.issn=1357650X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2006-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - LATEFV N1 - SubjectsTermNotLitGenreText - Semantic Processing (76760); Cerebral Dominance (11500); Lexical Decision Task (46645); Priming (67670); College Students (13250); Associative Processes (05300); Semantic Fields (76710) ER - TY - JOUR T1 - Harmaline-induced tremor as a potential preclinical screening method for essential tremor medications. AN - 85382636; pmid-15580562 AB - No preclinical method to evaluate potential new medications for essential tremor (ET) is available currently. Although harmaline tremor is a well known animal model of ET, it has not found utility as a preclinical drug screen and has not been validated with anti-ET medications. We measured harmaline tremor in rats (10 mg/kg s.c.) and mice (20 mg/kg s.c.) with a load sensor under the cage floor and performed spectral analysis on 20-minute epochs. The motion power over the tremor frequency bandwidth (8-12 Hz in rats; 10-16 Hz in mice) was divided by the motion power over the full motion frequency range (0-15 Hz in rats; 0-34 Hz in mice). The use of these measures greatly reduced data variability, permitting experiments with small sample sizes. Three drugs that suppress ET (propranolol, ethanol, and octanol) all significantly suppressed harmaline-induced tremor. We propose that, with this methodology, harmaline-induced tremor may be useful as a preclinical method to identify potential medications for ET.2005 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Martin, Fredricka C AU - Thu Le, Anh AU - Handforth, Adrian AD - Research Service, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA. fredricka.martin@med.va.gov Y1 - 2005/03// PY - 2005 DA - Mar 2005 SP - 298 EP - 305 VL - 20 IS - 3 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Central Nervous System Depressants: pharmacology KW - *Central Nervous System Depressants: therapeutic use KW - *Central Nervous System Stimulants: adverse effects KW - Essential Tremor: chemically induced KW - Essential Tremor: diagnosis KW - Essential Tremor: drug therapy KW - Ethanol: pharmacology KW - *Ethanol: therapeutic use KW - Female KW - *Harmaline: adverse effects KW - Locomotion: drug effects KW - Mice KW - Mice, Inbred ICR KW - Propranolol: pharmacology KW - *Propranolol: therapeutic use KW - Rats KW - Rats, Sprague-Dawley KW - Severity of Illness Index KW - Vasodilator Agents: pharmacology KW - *Vasodilator Agents: therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85382636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Harmaline-induced+tremor+as+a+potential+preclinical+screening+method+for+essential+tremor+medications.&rft.au=Martin%2C+Fredricka+C%3BThu+Le%2C+Anh%3BHandforth%2C+Adrian&rft.aulast=Martin&rft.aufirst=Fredricka&rft.date=2005-03-01&rft.volume=20&rft.issue=3&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Glucocorticoid-induced osteoporosis: treatment options and guidelines. AN - 68062243; 16036098 AB - Glucocorticoid-induced osteoporosis and fractures are the most frequent adverse effects of this class of medication. Recent advances in the pathophysiology, epidemiology, detection, and prevention of this complication of therapy provide hope for its amelioration in patients who require treatment with glucocorticoids. A number of effective pharmacologic agents are available and/or under study, and scientific organizations now provide guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis. Unfortunately, consistent application of these guidelines remains suboptimal in many practice settings. JF - Current osteoporosis reports AU - Maricic, Michael AD - Southern Arizona VA Health Care System, 3601 S. 6th Avenue, Tucson, AZ 85723, USA. michael.maricic@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 25 EP - 29 VL - 3 IS - 1 SN - 1544-1873, 1544-1873 KW - Diphosphonates KW - 0 KW - Glucocorticoids KW - Parathyroid Hormone KW - Etidronic Acid KW - M2F465ROXU KW - Risedronate Sodium KW - OFG5EXG60L KW - Alendronate KW - X1J18R4W8P KW - Index Medicus KW - Diphosphonates -- therapeutic use KW - Bone Resorption KW - Guideline Adherence KW - Humans KW - Alendronate -- therapeutic use KW - Exercise KW - Etidronic Acid -- therapeutic use KW - Bone Density -- drug effects KW - Practice Guidelines as Topic KW - Parathyroid Hormone -- therapeutic use KW - Fractures, Bone -- chemically induced KW - Osteogenesis -- drug effects KW - Etidronic Acid -- analogs & derivatives KW - Female KW - Male KW - Osteoporosis -- prevention & control KW - Glucocorticoids -- administration & dosage KW - Glucocorticoids -- adverse effects KW - Glucocorticoids -- therapeutic use KW - Osteoporosis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68062243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+osteoporosis+reports&rft.atitle=Glucocorticoid-induced+osteoporosis%3A+treatment+options+and+guidelines.&rft.au=Maricic%2C+Michael&rft.aulast=Maricic&rft.aufirst=Michael&rft.date=2005-03-01&rft.volume=3&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Current+osteoporosis+reports&rft.issn=15441873&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-07 N1 - Date created - 2005-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association between fecal hydrogen sulfide production and pouchitis. AN - 67796585; 15747080 AB - The beneficial effect of antibiotics in pouchitis suggests that an unidentified fecal bacterial product causes this condition. A candidate compound is hydrogen sulfide, a highly toxic gas produced by certain fecal bacteria, which causes tissue injury in experimental models. We investigated hydrogen sulfide release and sulfate-reducing bacterial counts in pouch contents to determine whether hydrogen sulfide production correlates with pouchitis. During incubation at 37 degrees C, the production of hydrogen sulfide, methylmercaptan, carbon dioxide, and hydrogen were studied using fresh fecal specimens obtained from 50 patients with ileoanal pouches constructed after total proctocolectomy for ulcerative colitis (n = 45) or for familial adenomatous polyposis (n = 5). Patients with ulcerative colitis were divided into five groups: a) no history of pouchitis (pouch for at least 2 years; n = 8); b) past episode(s) of pouchitis but no active disease for the previous year (n = 9); c) pouchitis in the past year but presently inactive (n = 9); d) ongoing antibiotic treatment (metronidazole or ciprofloxacin) for pouchitis (n = 11); e) currently suffering from pouchitis (n = 8). Release of hydrogen sulfide when pouchitis was active (6.06 +/- 1.03 micromol g(-1) 4 h(-1)) or had occurred in the past year (4.71 +/- 0.41 pmol g(-1) 4 h(-1)) was significantly higher (P < 0.05) than when pouchitis had never occurred (1.71 +/- 0.43 micromol g(-1) 4 h(-1)) or had been inactive in the past year (2.62 +/- 0.49 micromol g(-1) 4 h(-1)). Antibiotic therapy was associated with very low hydrogen sulfide release (0.68 +/- 0.29 micromol g(-1) 4 h(-1)). Pouch contents from familial adenomatous polyposis patients produced significantly less hydrogen sulfide (0.75 +/- 0.09 micromol g(-1) 4 h(-1)) than did any group of nonantibiotic-treated ulcerative colitis patients. Sulfate-reducing bacterial counts in active pouchitis (9.5 +/- 0.5 log10/g) were significantly higher than in those who never experienced pouchitis (7.38 +/- 0.32 log10/g), and these counts fell dramatically with antibiotic treatment. No statistically significant differences in carbon dioxide and hydrogen were observed among the groups not receiving antibiotics. Pouch contents of patients with ongoing pouchitis or an episode within the previous year released significantly more hydrogen sulfide than did the contents of patients who never had an attack of pouchitis and those with longstanding inactive disease. The response to therapy with metronidazole or ciprofloxacin was associated with marked reductions in hydrogen sulfide release and sulfate-reducing bacteria. These results provide a rationale for additional studies to determine whether the high sulfide production is a cause or effect of pouchitis. The lower hydrogen sulfide production by pouch contents of familial adenomatous polyposis vs. patients with ulcerative colitis suggests a fundamental difference in gut sulfide metabolism that could have implications for the etiology of ulcerative colitis as well as the pouchitis of patients with ulcerative colitis. JF - Diseases of the colon and rectum AU - Ohge, Hiroki AU - Furne, Julie K AU - Springfield, John AU - Rothenberger, David A AU - Madoff, Robert D AU - Levitt, Michael D AD - Minneapolis Veterans Administration Medical Center, Minneapolis, Minnesota, USA. ohge@hiroshima-u.ac.jp Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 469 EP - 475 VL - 48 IS - 3 SN - 0012-3706, 0012-3706 KW - Anti-Infective Agents KW - 0 KW - Metronidazole KW - 140QMO216E KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Hydrogen Sulfide KW - YY9FVM7NSN KW - Index Medicus KW - Anti-Infective Agents -- therapeutic use KW - Sulfur-Reducing Bacteria -- physiology KW - Metronidazole -- therapeutic use KW - Humans KW - Ciprofloxacin -- therapeutic use KW - Male KW - Female KW - Colitis, Ulcerative -- complications KW - Pouchitis -- microbiology KW - Pouchitis -- drug therapy KW - Pouchitis -- physiopathology KW - Hydrogen Sulfide -- adverse effects KW - Feces -- chemistry KW - Hydrogen Sulfide -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67796585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diseases+of+the+colon+and+rectum&rft.atitle=Association+between+fecal+hydrogen+sulfide+production+and+pouchitis.&rft.au=Ohge%2C+Hiroki%3BFurne%2C+Julie+K%3BSpringfield%2C+John%3BRothenberger%2C+David+A%3BMadoff%2C+Robert+D%3BLevitt%2C+Michael+D&rft.aulast=Ohge&rft.aufirst=Hiroki&rft.date=2005-03-01&rft.volume=48&rft.issue=3&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Diseases+of+the+colon+and+rectum&rft.issn=00123706&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-24 N1 - Date created - 2005-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of a stem cell candidate in the normal human prostate gland. AN - 67725893; 15819412 AB - Stem cells of the human prostate gland have not yet been identified utilizing a structural biomarker. We have discovered a new prostatic epithelial cell phenotype-expressing cytokeratin 6a (Ck6a+ cells). The Ck6a+ cells are present within a specialized niche in the basal cell compartment in fetal, juvenile and adult prostate tissue, and within the stem cell-enriched urogenital sinus. In adult normal prostate tissue, the average abundance of Ck6a+ cells was 4.9%. With proliferative stimuli in the prostate organ culture model, in which the epithelial-stromal interaction was maintained, a remarkable increase of Ck6a expression was noticed to up to 64.9%. The difference in cytokeratin 6a expression between the normal adult prostate and the prostate organ culture model was statistically significant (p<0.0001). Within the prostate organ culture model the increase of cytokeratin 6a-expressing cells significantly correlated with increased proliferation index (r = 0.7616, p = 0.0467). The Ck6a+ cells were capable of differentiation as indicated by their expression of luminal cell markers such as ZO-1 and prostate specific antigen (PSA). Our data indicate that Ck6a+ cells represent a prostatic epithelial stem cell candidate possessing high potential for proliferation and differentiation. Since the development of benign prostatic hyperplasia and prostate carcinogenesis are disorders of proliferation and differentiation, the Ck6a+ cells may represent a major element in the development of these diseases. JF - European journal of cell biology AU - Schmelz, Monika AU - Moll, Roland AU - Hesse, Ulrike AU - Prasad, Anil R AU - Gandolfi, Jay A AU - Hasan, Shirin R AU - Bartholdi, Marty AU - Cress, Anne E AD - Department of Pathology, Southern Arizona Veterans Affairs Health Care System, 3601 S. 6th Ave., Tucson, AZ 85723, USA. monika.schmelz@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 341 EP - 354 VL - 84 IS - 2-3 SN - 0171-9335, 0171-9335 KW - Antibodies, Monoclonal KW - 0 KW - Biomarkers KW - Keratins KW - 68238-35-7 KW - Index Medicus KW - Keratins -- metabolism KW - Keratins -- genetics KW - Cell Differentiation -- physiology KW - Humans KW - Epithelium -- metabolism KW - Cell Proliferation KW - Fetus -- metabolism KW - Male KW - Prostate -- metabolism KW - Stem Cells KW - Prostate -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67725893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cell+biology&rft.atitle=Identification+of+a+stem+cell+candidate+in+the+normal+human+prostate+gland.&rft.au=Schmelz%2C+Monika%3BMoll%2C+Roland%3BHesse%2C+Ulrike%3BPrasad%2C+Anil+R%3BGandolfi%2C+Jay+A%3BHasan%2C+Shirin+R%3BBartholdi%2C+Marty%3BCress%2C+Anne+E&rft.aulast=Schmelz&rft.aufirst=Monika&rft.date=2005-03-01&rft.volume=84&rft.issue=2-3&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cell+biology&rft.issn=01719335&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-05 N1 - Date created - 2005-04-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Histochem Cytochem. 2001 Feb;49(2):271-8 [11156695] J Invest Dermatol. 2000 Nov;115(5):795-804 [11069616] Prostate. 2001 Oct 1;49(2):132-9 [11582592] Nature. 2001 Nov 1;414(6859):98-104 [11689954] J Cell Sci. 2001 Nov;114(Pt 21):3865-72 [11719553] Neoplasia. 2002 May-Jun;4(3):243-54 [11988844] Cell Biol Toxicol. 2002;18(3):205-19 [12083426] J Urol. 2002 Nov;168(5):2206-10 [12394760] J Invest Dermatol. 2003 Apr;120(4):512-22 [12648212] Tissue Cell. 2003 Apr;35(2):83-93 [12747930] Oncogene. 2003 Jun 19;22(25):3875-87 [12813461] Med Electron Microsc. 2003 Sep;36(3):147-56 [14505058] Urology. 2003 Nov;62(5 Suppl 1):11-20 [14607213] Nat Rev Cancer. 2003 Nov;3(11):832-44 [14668814] J Cell Sci. 2004 Apr 15;117(Pt 10):1989-99 [15090596] J Cell Sci. 2004 Jul 15;117(Pt 16):3539-45 [15226377] Invest Urol. 1978 Jan;15(4):340-5 [75197] J Biol Chem. 1978 Mar 25;253(6):2053-60 [416022] Anat Rec. 1980 Mar;196(3):263-73 [7406220] Cell. 1982 Nov;31(1):11-24 [6186379] Am J Clin Pathol. 1985 Apr;83(4):431-8 [2580429] Prostate. 1985;7(1):41-51 [4080651] Methods Enzymol. 1986;134:355-71 [2434826] Endocr Rev. 1987 Aug;8(3):338-62 [3308446] Prog Clin Biol Res. 1987;239:513-76 [3309963] Prostate. 1987;11(3):229-42 [3684783] Am J Surg Pathol. 1988 Aug;12(8):619-33 [2456702] Am J Clin Pathol. 1988 Nov;90(5):597-601 [2459960] J Invest Dermatol. 1989 May;92(5):707-16 [2469734] J Urol. 1990 Jan;143(1):167-71 [1688457] Prostate Suppl. 1989;2:33-50 [2482772] Mol Endocrinol. 1990 Dec;4(12):2003-13 [1707130] Cancer Res. 1992 Nov 15;52(22):6182-7 [1384957] Cancer Res. 1993 Oct 1;53(19):4720-6 [7691403] Hum Pathol. 1994 Jan;25(1):42-6 [7508883] Prostate. 1996 Feb;28(2):98-106 [8604398] Ann N Y Acad Sci. 1996 Apr 30;784:50-62 [8651606] Acta Anat (Basel). 1996;155(2):81-93 [8828706] Science. 1996 Dec 6;274(5293):1672-7 [8939849] Cancer. 1997 Apr 15;79(8):1595-9 [9118044] Eur Urol. 1997;32(3):332-8 [9358223] Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1735-40 [9465086] Genomics. 1998 Oct 15;53(2):170-83 [9790766] J Urol. 1998 Dec;160(6 Pt 2):2381-92 [9817389] Gastroenterology. 1999 Jan;116(1):7-14 [9869596] Subcell Biochem. 1998;31:173-204 [9932493] Lab Invest. 2000 Aug;80(8):1251-8 [10950116] J Pathol. 1999 Oct;189(2):213-8 [10547577] Cancer Metastasis Rev. 1998-1999;17(4):391-9 [10453283] Cell. 2001 Jan 26;104(2):233-45 [11207364] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationship of aging and tobacco use with the development of aberrant crypt foci in a predominantly African-American population. AN - 67513775; 15765447 AB - In clinical studies, diminished folate availability appears to increase the risk for colorectal neoplasms. Additionally, alcohol and tobacco use are associated with an increased risk for colon cancer, but the early pathologic events by which these agents promote neoplastic transformation are not well understood. Aberrant crypt foci (ACF) are potential precursors of adenoma and cancer, and can be visualized by magnification endoscopy. We hypothesized that folate depletion is linked to ACF formation and therefore studied the association between tissue folate, dietary habits, and ACF number in patients undergoing screening colonoscopy. Eighty-three patients, undergoing screening colonoscopy at an urban Veterans Affairs and university hospital, completed a questionnaire concerning alcohol, nonsteroidal anti-inflammatory drug (NSAID), and tobacco use. Folate intake was calculated from food frequency questionnaires. Rectal ACFs were scored using magnification chromoendoscopy (magnification, 35 x) by methylene blue staining. Folate concentrations in rectal biopsy specimens were determined by microtiter bioassay. ACF number increased with age and with increasing tobacco intake. Decreased colonic folate level was associated with increased homocysteine levels and lower dietary folate intake but did not correlate with ACF number. Increasing age and tobacco use were linked independently to the presence of colonic ACF in this predominantly African-American population. Folate, alcohol, and acetylsalicylic acid (ASA) use did not influence the prevalence of these lesions. JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association AU - Moxon, Darran AU - Raza, Mamoon AU - Kenney, Richard AU - Ewing, Ronald AU - Arozullah, Ahsan AU - Mason, Joel B AU - Carroll, Robert E AD - Department of Medicine, University of Illinois at Chicago and Chicago Veterans Administration Medical Center, Chicago, Illinois 60612, USA. Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 271 EP - 278 VL - 3 IS - 3 SN - 1542-3565, 1542-3565 KW - Index Medicus KW - Aging -- physiology KW - Folic Acid Deficiency -- complications KW - Colonoscopy KW - Humans KW - Smoking -- adverse effects KW - Intestinal Mucosa -- pathology KW - Aged KW - African Americans KW - Urban Population KW - Tobacco Use Disorder -- complications KW - Male KW - Female KW - Colonic Neoplasms -- etiology KW - Precancerous Conditions -- etiology KW - Precancerous Conditions -- diagnosis KW - Colonic Neoplasms -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67513775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+gastroenterology+and+hepatology+%3A+the+official+clinical+practice+journal+of+the+American+Gastroenterological+Association&rft.atitle=Relationship+of+aging+and+tobacco+use+with+the+development+of+aberrant+crypt+foci+in+a+predominantly+African-American+population.&rft.au=Moxon%2C+Darran%3BRaza%2C+Mamoon%3BKenney%2C+Richard%3BEwing%2C+Ronald%3BArozullah%2C+Ahsan%3BMason%2C+Joel+B%3BCarroll%2C+Robert+E&rft.aulast=Moxon&rft.aufirst=Darran&rft.date=2005-03-01&rft.volume=3&rft.issue=3&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Clinical+gastroenterology+and+hepatology+%3A+the+official+clinical+practice+journal+of+the+American+Gastroenterological+Association&rft.issn=15423565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-28 N1 - Date created - 2005-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sleep attacks in patients receiving dopamine-receptor agonists. AN - 67485444; 15745920 JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Plowman, Brian K AU - Boggie, Daniel T AU - Morreale, Anthony P AU - Schaefer, Monica G AU - Delattre, Melissa L AU - Chan, Henry AD - Veterans Affairs San Diego Healthcare System (VASDHS), San Diego, CA 92161, USA. brian.plowman@med.va.gov Y1 - 2005/03/01/ PY - 2005 DA - 2005 Mar 01 SP - 537 EP - 540 VL - 62 IS - 5 SN - 1079-2082, 1079-2082 KW - Benzothiazoles KW - 0 KW - Dopamine Agonists KW - Indoles KW - Thiazoles KW - ropinirole KW - 030PYR8953 KW - Pergolide KW - 24MJ822NZ9 KW - pramipexole KW - 83619PEU5T KW - Index Medicus KW - Pergolide -- adverse effects KW - Pergolide -- therapeutic use KW - Humans KW - Indoles -- adverse effects KW - Indoles -- therapeutic use KW - Aged KW - Middle Aged KW - Thiazoles -- adverse effects KW - Thiazoles -- therapeutic use KW - Male KW - Female KW - Dopamine Agonists -- therapeutic use KW - Restless Legs Syndrome -- drug therapy KW - Dopamine Agonists -- adverse effects KW - Parkinson Disease -- drug therapy KW - Narcolepsy -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67485444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Sleep+attacks+in+patients+receiving+dopamine-receptor+agonists.&rft.au=Plowman%2C+Brian+K%3BBoggie%2C+Daniel+T%3BMorreale%2C+Anthony+P%3BSchaefer%2C+Monica+G%3BDelattre%2C+Melissa+L%3BChan%2C+Henry&rft.aulast=Plowman&rft.aufirst=Brian&rft.date=2005-03-01&rft.volume=62&rft.issue=5&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-14 N1 - Date created - 2005-03-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Personality and comorbidity of common psychiatric disorders. AN - 67471266; 15738498 AB - We know little about the degree to which comorbidity, socommonly seen among psychiatric disorders, arises from variation in normal personality. To study the degree to which variation in normal personality accounts for the comorbidity of eight common psychiatric and substance use disorders. Internalising disorders (major depression, generalised anxiety and panic disorders, phobias), externalising disorders (alcohol and drug dependence, antisocial personality and conduct disorders) and personality dimensions of neuroticism, extraversion and novelty seeking were assessed in 7588 participants from a population-based twin registry. The proportion of comorbidity explained by each personality dimension was calculated using structural equation modelling. Neuroticism accounted for the highest proportion of comorbidity within internalising disorders (20-45%) and between internalising and externalising disorders (19-88%). Variation in neuroticism and novelty seeking each accounted for a modest proportion (10-12% and 7-14%, respectively) of the comorbidity within externalising disorders. Extraversion contributed negligibly. High neuroticism appears to be a broad vulnerability factor for comorbid psychiatric disorders. Novelty seeking is modestly important for comorbid externalising disorders. JF - The British journal of psychiatry : the journal of mental science AU - Khan, Amir A AU - Jacobson, Kristen C AU - Gardner, Charles O AU - Prescott, Carol A AU - Kendler, Kenneth S AD - Mental Health and Behavioral Sciences Service, Providence VA Medical Center, 830 Chalkstone Ave., Providence, RI 02908, USA. amir.khan2@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 190 EP - 196 VL - 186 SN - 0007-1250, 0007-1250 KW - Index Medicus KW - Sex Factors KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Exploratory Behavior KW - Neurotic Disorders -- epidemiology KW - Comorbidity KW - Logistic Models KW - Virginia -- epidemiology KW - Adult KW - Middle Aged KW - Female KW - Male KW - Substance-Related Disorders -- epidemiology KW - Prevalence KW - Mental Disorders -- epidemiology KW - Personality KW - Diseases in Twins -- epidemiology KW - Mental Disorders -- psychology KW - Diseases in Twins -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67471266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+journal+of+psychiatry+%3A+the+journal+of+mental+science&rft.atitle=Personality+and+comorbidity+of+common+psychiatric+disorders.&rft.au=Khan%2C+Amir+A%3BJacobson%2C+Kristen+C%3BGardner%2C+Charles+O%3BPrescott%2C+Carol+A%3BKendler%2C+Kenneth+S&rft.aulast=Khan&rft.aufirst=Amir&rft.date=2005-03-01&rft.volume=186&rft.issue=&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=The+British+journal+of+psychiatry+%3A+the+journal+of+mental+science&rft.issn=00071250&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-07 N1 - Date created - 2005-03-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Br J Psychiatry. 2005 Mar;186:182-4 [15738496] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment and its correlates in the NESARC. AN - 67462728; 15733238 JF - Addiction (Abingdon, England) AU - Finney, John W AD - Center for Health Care Evaluation, VA Palo Alto Health Care System (152), 795 Willow Road, Menlo Park, CA 94025, USA. John.Finney@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 293; discussion 296 EP - 8 VL - 100 IS - 3 SN - 0965-2140, 0965-2140 KW - Index Medicus KW - Humans KW - Health Surveys KW - Treatment Outcome KW - United States -- epidemiology KW - Remission, Spontaneous KW - Alcoholism -- rehabilitation KW - Alcoholism -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67462728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Treatment+and+its+correlates+in+the+NESARC.&rft.au=Finney%2C+John+W&rft.aulast=Finney&rft.aufirst=John&rft.date=2005-03-01&rft.volume=100&rft.issue=3&rft.spage=293%3B+discussion+296&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-07 N1 - Date created - 2005-02-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Addiction. 2005 Mar;100(3):281-92 [15733237] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A placebo-controlled screening trial of olanzapine, valproate, and coenzyme Q10/L-carnitine for the treatment of cocaine dependence. AN - 67461418; 15730349 AB - To conduct a medication screening trial on the efficacy of olanzapine, valproate or coenzyme Q10/L-carnitine combination versus placebo for the treatment of cocaine dependence. A four-arm, modified blinded, parallel group study in an out-patient setting using the Cocaine Rapid Efficacy and Safety Trials (CREST) study design. The study was performed at the New York Medications Development Research Unit (MDRU). All participants met Diagnostic and Statistical Manual version IV (DSM-IV) criteria for cocaine dependence and provided at least two urine samples positive for benzoylecgonine (BE) during the 2-week screening period. Sixty-eight participants were enrolled with 39 completing the study. After a 2-week screening period, 68 subjects were assigned randomly to receive either olanzapine (10 mg/day), valproate (1500 mg/day), coenzyme Q10 (200 mg/day) and L-carnitine (500 mg/day) combination or placebo for an 8-week treatment period. All subjects also received individual cognitive behavioral counseling during treatment. Primary outcome measures included quantitative urine benzoylecgonine (BE) levels, self-report of drug use, and global impression scores. Secondary outcomes included cocaine craving, study retention and related psychosocial measures. Safety measures included adverse event monitoring, vital signs, and extrapyramidal side-effects tests. Study retention was similar across all treatment groups, and all groups showed improvement across most measures of treatment efficacy over the duration of the study. None of the study medications, however, were superior to placebo on any of the primary or secondary outcome measures. Cocaine use, as measured by urine BE levels and self-report, was not significantly lower than placebo in any of the drug treatment groups. All study medications were equally well tolerated, and few medication side effects were observed. This pilot study does not support the effectiveness of olanzapine, valproate or coenzyme Q10/L-carnitine combination for the treatment of cocaine dependence. JF - Addiction (Abingdon, England) AU - Reid, Malcolm S AU - Casadonte, Paul AU - Baker, Sherryl AU - Sanfilipo, Michael AU - Braunstein, Dania AU - Hitzemann, Robert AU - Montgomery, Ann AU - Majewska, Dorota AU - Robinson, James AU - Rotrosen, John AD - Department of Psychiatry, New York University School of Medicine, VA New York Harbor Healthcare System, New York, NY 10010, USA. malcolm.reid@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 43 EP - 57 VL - 100 Suppl 1 SN - 0965-2140, 0965-2140 KW - Anticonvulsants KW - 0 KW - Coenzymes KW - Serotonin Uptake Inhibitors KW - Benzodiazepines KW - 12794-10-4 KW - Ubiquinone KW - 1339-63-5 KW - Valproic Acid KW - 614OI1Z5WI KW - coenzyme Q10 KW - EJ27X76M46 KW - olanzapine KW - N7U69T4SZR KW - Carnitine KW - S7UI8SM58A KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Adult KW - Pilot Projects KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Benzodiazepines -- therapeutic use KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Ubiquinone -- therapeutic use KW - Valproic Acid -- therapeutic use KW - Carnitine -- therapeutic use KW - Anticonvulsants -- therapeutic use KW - Cocaine-Related Disorders -- rehabilitation KW - Ubiquinone -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67461418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=A+placebo-controlled+screening+trial+of+olanzapine%2C+valproate%2C+and+coenzyme+Q10%2FL-carnitine+for+the+treatment+of+cocaine+dependence.&rft.au=Reid%2C+Malcolm+S%3BCasadonte%2C+Paul%3BBaker%2C+Sherryl%3BSanfilipo%2C+Michael%3BBraunstein%2C+Dania%3BHitzemann%2C+Robert%3BMontgomery%2C+Ann%3BMajewska%2C+Dorota%3BRobinson%2C+James%3BRotrosen%2C+John&rft.aulast=Reid&rft.aufirst=Malcolm&rft.date=2005-03-01&rft.volume=100+Suppl+1&rft.issue=&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-23 N1 - Date created - 2005-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of pentoxifylline and vitamin E in attenuation of radiation-induced fibrosis. AN - 67457130; 15701781 AB - To evaluate the use of pentoxifylline and vitamin E as monotherapy and in combination for the treatment of radiation-induced fibrosis (RIF). Literature retrieval was performed through MEDLINE (1966-March 2004) using the terms vitamin E, alpha-tocopherol, pentoxifylline, radiation-induced fibrosis, and radiation injury. Few treatments exist for managing RIF of soft tissues. Due to its antioxidant properties, vitamin E may reduce the oxidative damage induced by radiation. The precise mechanism of action for pentoxifylline in management of RIF remains unclear. Uncontrolled studies evaluating vitamin E or pentoxifylline as monotherapy in RIF have shown modest improvement in clinical regression of fibrosis. However, controlled data are needed to verify these benefits. Studies involving pentoxifylline plus vitamin E demonstrated regression in RIF. The combination was more effective than placebo and may be superior to monotherapy with either agent. Adverse effects were rarely reported in the studies and consisted mainly of gastrointestinal and nervous system effects. Overall, pentoxifylline is well tolerated and is one of the few commercially available drugs with clinical data for management of RIF. Despite a lack of large, well-designed clinical trials, pentoxifylline plus vitamin E should be considered as an option in patients with symptomatic RIF. JF - The Annals of pharmacotherapy AU - Chiao, Teresa B AU - Lee, Audrey J AD - Veterans Affairs (VA) Medical Center, San Francisco, CA 94121-1545, USA. teresa.chiao@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 516 EP - 522 VL - 39 IS - 3 SN - 1060-0280, 1060-0280 KW - Antioxidants KW - 0 KW - Platelet Aggregation Inhibitors KW - Vitamin E KW - 1406-18-4 KW - Pentoxifylline KW - SD6QCT3TSU KW - Index Medicus KW - Drug Therapy, Combination KW - Fibrosis KW - Humans KW - Clinical Trials as Topic KW - Radiation Injuries -- drug therapy KW - Platelet Aggregation Inhibitors -- therapeutic use KW - Pentoxifylline -- therapeutic use KW - Radiation Injuries -- prevention & control KW - Antioxidants -- therapeutic use KW - Vitamin E -- therapeutic use KW - Vitamin E -- administration & dosage KW - Pentoxifylline -- administration & dosage KW - Platelet Aggregation Inhibitors -- administration & dosage KW - Antioxidants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67457130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Role+of+pentoxifylline+and+vitamin+E+in+attenuation+of+radiation-induced+fibrosis.&rft.au=Chiao%2C+Teresa+B%3BLee%2C+Audrey+J&rft.aulast=Chiao&rft.aufirst=Teresa&rft.date=2005-03-01&rft.volume=39&rft.issue=3&rft.spage=516&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-06 N1 - Date created - 2005-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A placebo-controlled screening trial of celecoxib for the treatment of cocaine dependence. AN - 67456332; 15730348 AB - To conduct a medication screening trial study on the efficacy of celecoxib versus placebo for the treatment of cocaine dependence. A modified blinded, parallel group study in an outpatient setting using the Cocaine Rapid Efficacy and Safety Trials (CREST) study design. The study was performed at the New York Medications Development Research Unit (MDRU). All participants met Diagnostic and Statistical Manual version IV (DSM-IV) criteria for cocaine dependence and provided at least two urine samples positive for benzoylecgonine (BE) during the 2-week screening period. Twenty-three participants were enrolled in the treatment phase of the study. After a 2-week screening period, subjects were assigned randomly to receive either celebrex (200 mg/day) or placebo for an 8-week treatment period. All subjects also received individual cognitive behavioral counseling during treatment. Primary outcome measures included quantitative urine benzoylecgonine (BE) levels, self-report of drug use and global impression scores. Secondary outcomes included cocaine craving, study retention and related psychosocial measures. Safety measures included adverse event monitoring, vital signs and extrapyramidal side-effects tests. Study retention was similar across both treatment groups and safety measures indicated that celecoxib was moderately tolerated. Cocaine use, as measured by self-report and urine BE levels at end of treatment, indicated weaker improvement in the celecoxib group. Reductions in the intensity of cocaine craving were also weaker in the celecoxib group. Cocaine abstinence rates, global impression scores and all other related psychometric measures did not differ significantly between treatment groups. This study does not support the effectiveness of celecoxib for the treatment of cocaine dependence. JF - Addiction (Abingdon, England) AU - Reid, Malcolm S AU - Angrist, Burt AU - Baker, Sherryl AU - Woo, Caroline AU - Schwartz, Marion AU - Montgomery, Ann AU - Majewska, Dorota AU - Robinson, James AU - Rotrosen, John AD - Department of Psychiatry, New York University School of Medicine, VA New York Harbor Healthcare System, New York, NY 10010, USA. malcolm.reid@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 32 EP - 42 VL - 100 Suppl 1 SN - 0965-2140, 0965-2140 KW - Cyclooxygenase Inhibitors KW - 0 KW - Pyrazoles KW - Sulfonamides KW - Celecoxib KW - JCX84Q7J1L KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Adult KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Cyclooxygenase Inhibitors -- therapeutic use KW - Cyclooxygenase Inhibitors -- administration & dosage KW - Pyrazoles -- therapeutic use KW - Sulfonamides -- therapeutic use KW - Cocaine-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67456332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=A+placebo-controlled+screening+trial+of+celecoxib+for+the+treatment+of+cocaine+dependence.&rft.au=Reid%2C+Malcolm+S%3BAngrist%2C+Burt%3BBaker%2C+Sherryl%3BWoo%2C+Caroline%3BSchwartz%2C+Marion%3BMontgomery%2C+Ann%3BMajewska%2C+Dorota%3BRobinson%2C+James%3BRotrosen%2C+John&rft.aulast=Reid&rft.aufirst=Malcolm&rft.date=2005-03-01&rft.volume=100+Suppl+1&rft.issue=&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-23 N1 - Date created - 2005-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of the metabolic effects observed in patients treated with ziprasidone versus olanzapine. AN - 67455807; 15729087 AB - This study aimed to examine the impact of ziprasidone and olanzapine on QTc interval, weight and metabolic parameters in adults with schizophrenia and other psychoses. A retrospective cohort chart review was performed of 191 randomly selected patients who were being treated with ziprasidone or olanzapine in an integrated health care system. Significant differences on QTc interval were not observed. A significant weight gain was observed in olanzapine-treated patients (P0.05). Furthermore, adverse metabolic changes associated with olanzapine administration were significant with respect to effects on total cholesterol (P=0.01), triglycerides (P=0.05) and haemoglobin A1C (HbA1C) (P<0.05), whereas significant favourable metabolic effects were observed in ziprasidone-treated patients with regard to total cholesterol (P<0.05), low-density lipoprotein (LDL) (P<0.01), high-density lipoprotein (HDL) (P<0.05) and HbA1c (P<0.05). Our results suggest that these two atypical antipsychotics are safe and well tolerated from a cardiovascular standpoint, with no differences in QTc interval prolongation being observed. Olanzapine-treated patients exhibited significant weight increases, whereas ziprasidone-treated patients exhibited weight loss. Olanzapine treatment was also associated with significant adverse effect on patient's lipid profile and HbA1c. These adverse metabolic effects were not observed in ziprasidone-treated patients although favourable effects were observed with regard to effect on total cholesterol, LDL, HDL and HbA1c. JF - International clinical psychopharmacology AU - Brown, Ronald R AU - Estoup, Michael W AD - Department of Veterans Affairs Medical Center, Portland, OR 97239, USA. ronald.brown@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 105 EP - 112 VL - 20 IS - 2 SN - 0268-1315, 0268-1315 KW - Antipsychotic Agents KW - 0 KW - Blood Glucose KW - Cholesterol, HDL KW - Cholesterol, LDL KW - Hemoglobin A, Glycosylated KW - Lipids KW - Piperazines KW - Thiazoles KW - Triglycerides KW - Benzodiazepines KW - 12794-10-4 KW - ziprasidone KW - 6UKA5VEJ6X KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - Lipids -- blood KW - Triglycerides -- blood KW - Cholesterol, LDL -- blood KW - Blood Glucose -- metabolism KW - Schizophrenia -- metabolism KW - Humans KW - Retrospective Studies KW - Aged KW - Heart Rate -- drug effects KW - Aged, 80 and over KW - Cholesterol, HDL -- blood KW - Hemoglobin A, Glycosylated -- metabolism KW - Adult KW - Body Weight -- drug effects KW - Schizophrenia -- drug therapy KW - Middle Aged KW - Male KW - Female KW - Electrocardiography -- drug effects KW - Benzodiazepines -- therapeutic use KW - Benzodiazepines -- adverse effects KW - Piperazines -- therapeutic use KW - Hyperlipidemias -- chemically induced KW - Antipsychotic Agents -- therapeutic use KW - Thiazoles -- adverse effects KW - Piperazines -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Hyperlipidemias -- blood KW - Thiazoles -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67455807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+clinical+psychopharmacology&rft.atitle=Comparison+of+the+metabolic+effects+observed+in+patients+treated+with+ziprasidone+versus+olanzapine.&rft.au=Brown%2C+Ronald+R%3BEstoup%2C+Michael+W&rft.aulast=Brown&rft.aufirst=Ronald&rft.date=2005-03-01&rft.volume=20&rft.issue=2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=International+clinical+psychopharmacology&rft.issn=02681315&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-13 N1 - Date created - 2005-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - General-medical conditions in older patients with serious mental illness. AN - 67454689; 15728757 AB - The burden of medical comorbidities was compared between older (> or =60 years) and younger patients with serious mental illness. Patients (N=8,083) diagnosed with schizophrenia, schizoaffective disorder, or bipolar disorder in 2001 were identified from VA facilities in the mid-Atlantic region. Medical comorbidities were identified by an ICD-9-based clinical classification algorithm. Older, versus younger, patients were more likely to be diagnosed with cardiovascular or pulmonary conditions, and less likely to be diagnosed with substance-use disorders or hepatic conditions. More aggressive detection and management of general-medical comorbidities in older patients with serious mental illness is paramount. JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry AU - Kilbourne, Amy M AU - Cornelius, Jack R AU - Han, Xiaoyan AU - Haas, Gretchen L AU - Salloum, Ihsan AU - Conigliaro, Joseph AU - Pincus, Harold A AD - VA Pittsburgh Center for Health Equity Research and Promotion (151-C), University Drive C, Pittsburgh, PA 15240, USA. Amy.Kilbourne@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 250 EP - 254 VL - 13 IS - 3 SN - 1064-7481, 1064-7481 KW - Index Medicus KW - Liver Diseases -- epidemiology KW - Epidemiologic Methods KW - Cardiovascular Diseases -- epidemiology KW - Humans KW - Neoplasms -- epidemiology KW - Lung Diseases -- epidemiology KW - Middle Aged KW - Endocrine System Diseases -- epidemiology KW - Male KW - Female KW - Comorbidity KW - Substance-Related Disorders -- epidemiology KW - Bipolar Disorder -- epidemiology KW - Schizophrenia -- epidemiology KW - Psychotic Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67454689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+geriatric+psychiatry+%3A+official+journal+of+the+American+Association+for+Geriatric+Psychiatry&rft.atitle=General-medical+conditions+in+older+patients+with+serious+mental+illness.&rft.au=Kilbourne%2C+Amy+M%3BCornelius%2C+Jack+R%3BHan%2C+Xiaoyan%3BHaas%2C+Gretchen+L%3BSalloum%2C+Ihsan%3BConigliaro%2C+Joseph%3BPincus%2C+Harold+A&rft.aulast=Kilbourne&rft.aufirst=Amy&rft.date=2005-03-01&rft.volume=13&rft.issue=3&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+geriatric+psychiatry+%3A+official+journal+of+the+American+Association+for+Geriatric+Psychiatry&rft.issn=10647481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-11 N1 - Date created - 2005-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Substance use disorder comorbidity in major depressive disorder: an exploratory analysis of the Sequenced Treatment Alternatives to Relieve Depression cohort. AN - 67449496; 15723023 AB - Patients with major depressive disorder (MDD) often present with concurrent substance use disorders (SUD) involving alcohol and/or illicit drugs. This analysis compares the depressive symptomatic presentation and a range of clinical and demographic features of patients with MDD and concurrent SUD symptoms vs those without SUD symptoms, to clarify how these two differ and to determine whether concurrent SUD symptoms may alter the clinical presentation of MDD. The first 1500 outpatients with nonpsychotic MDD enrolled in the Sequenced Treatment Alternatives to Relieve Depression study were divided into those with and without concurrent SUD symptoms as ascertained by a self-report instrument, the Psychiatric Diagnostic Screening Questionnaire (PDSQ). Of the 1484 cases with completed baseline PDSQ, 28% (n = 419) of patients with MDD were found to endorse symptoms consistent with current SUD. Patients with symptoms consistent with SUD were more likely to be men (P < .0001), to be either divorced or never married (P = .018), to have a younger age of onset of depression (P = .014), and to have a higher rate of previous suicide attempts (P = .014) than those without SUD symptoms. Patients with major depressive disorder who have symptoms consistent with SUD endorsed greater functional impairment attributable to their illness than those without concurrent SUD symptoms (P = .0111). The presence of SUD symptoms did not alter the overall depressive symptom pattern of presentation, except that the dual-diagnosed patients had higher levels of hypersomnia (P = .006), anxious mood (P = .047), and suicidal ideation (P = .036) compared to those without SUD symptoms. In conclusion, gender, marital status, age of onset of major depression, functional impairment, and suicide risk factors differ in depressed patients with concurrent SUD symptoms compared to those without SUD comorbidity. JF - Comprehensive psychiatry AU - Davis, Lori L AU - Rush, John A AU - Wisniewski, Stephen R AU - Rice, Kayla AU - Cassano, Paolo AU - Jewell, Michele E AU - Biggs, Melanie M AU - Shores-Wilson, Kathy AU - Balasubramani, G K AU - Husain, Mustafa M AU - Quitkin, Frederic M AU - McGrath, Patrick J AD - VA Medical Center, Tuscaloosa, AL 35404, USA. lori.davis@med.va.gov PY - 2005 SP - 81 EP - 89 VL - 46 IS - 2 SN - 0010-440X, 0010-440X KW - Antidepressive Agents KW - 0 KW - Cyclohexanols KW - Street Drugs KW - Bupropion KW - 01ZG3TPX31 KW - Citalopram KW - 0DHU5B8D6V KW - Venlafaxine Hydrochloride KW - 7D7RX5A8MO KW - Sertraline KW - QUC7NX6WMB KW - Buspirone KW - TK65WKS8HL KW - Index Medicus KW - Bupropion -- therapeutic use KW - Suicide, Attempted -- psychology KW - Buspirone -- therapeutic use KW - Humans KW - Antidepressive Agents -- adverse effects KW - Comorbidity KW - Ambulatory Care KW - Adult KW - Treatment Outcome KW - Cyclohexanols -- adverse effects KW - Personality Assessment KW - Male KW - Citalopram -- adverse effects KW - Diagnosis, Differential KW - Buspirone -- adverse effects KW - Bupropion -- adverse effects KW - Personality Inventory KW - Sertraline -- adverse effects KW - Citalopram -- therapeutic use KW - Risk KW - Sertraline -- therapeutic use KW - Suicide, Attempted -- statistics & numerical data KW - Cognitive Therapy KW - Antidepressive Agents -- therapeutic use KW - Follow-Up Studies KW - Middle Aged KW - Cyclohexanols -- therapeutic use KW - Alcoholism -- rehabilitation KW - Substance-Related Disorders -- diagnosis KW - Depressive Disorder, Major -- diagnosis KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Depressive Disorder, Major -- epidemiology KW - Depressive Disorder, Major -- rehabilitation KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67449496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comprehensive+psychiatry&rft.atitle=Substance+use+disorder+comorbidity+in+major+depressive+disorder%3A+an+exploratory+analysis+of+the+Sequenced+Treatment+Alternatives+to+Relieve+Depression+cohort.&rft.au=Davis%2C+Lori+L%3BRush%2C+John+A%3BWisniewski%2C+Stephen+R%3BRice%2C+Kayla%3BCassano%2C+Paolo%3BJewell%2C+Michele+E%3BBiggs%2C+Melanie+M%3BShores-Wilson%2C+Kathy%3BBalasubramani%2C+G+K%3BHusain%2C+Mustafa+M%3BQuitkin%2C+Frederic+M%3BMcGrath%2C+Patrick+J&rft.aulast=Davis&rft.aufirst=Lori&rft.date=2005-03-01&rft.volume=46&rft.issue=2&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Comprehensive+psychiatry&rft.issn=0010440X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-09 N1 - Date created - 2005-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The impact of contracting and prompting substance abuse treatment entry: a pilot trial. AN - 67440299; 15718059 AB - Contracting and prompting clients to attend substance abuse treatment aftercare substantially improves treatment adherence and outcome. However, this approach has not been evaluated for improving entry into initial treatment. We recruited 102 individuals scheduled to begin a 28-day substance use disorder (SUD) residential treatment program and randomly assigned them to receive either our standard treatment (STX) or STX plus attendance contracting and prompting (CP). CP participants showed fewer subsequent hospitalization days, lower hospitalization costs, greater improvement in alcohol problem scores, and lower legal problem scores at a 3-month follow-up than the STX group. The two groups did not differ on treatment entry rate, time in treatment, or drug use problem scores. The clinical utility of CP procedures and areas for future research are discussed. JF - Addictive behaviors AU - Lash, Steven J AU - Gilmore, Jerome D AU - Burden, Jennifer L AU - Weaver, Kendra R AU - Blosser, Sharon L AU - Finney, Montenique L AD - Mental Health Service Line, Substance Abuse Residential Rehabilitation Treatment Program (116A4), Veterans Affairs Medical Center, Salem, VA 24153, USA. Steven.Lash@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 415 EP - 422 VL - 30 IS - 3 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Alcoholism -- rehabilitation KW - Humans KW - Patient Compliance -- psychology KW - Hospitalization -- economics KW - Pilot Projects KW - Alcoholism -- economics KW - Alcoholism -- psychology KW - Residential Treatment -- methods KW - Treatment Outcome KW - Middle Aged KW - Costs and Cost Analysis -- economics KW - Time Factors KW - Female KW - Male KW - Substance-Related Disorders -- economics KW - Patient Acceptance of Health Care -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67440299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=The+impact+of+contracting+and+prompting+substance+abuse+treatment+entry%3A+a+pilot+trial.&rft.au=Lash%2C+Steven+J%3BGilmore%2C+Jerome+D%3BBurden%2C+Jennifer+L%3BWeaver%2C+Kendra+R%3BBlosser%2C+Sharon+L%3BFinney%2C+Montenique+L&rft.aulast=Lash&rft.aufirst=Steven&rft.date=2005-03-01&rft.volume=30&rft.issue=3&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-13 N1 - Date created - 2005-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Predicting alcohol and drug abuse in Persian Gulf War veterans: what role do PTSD symptoms play? AN - 67436293; 15718078 AB - This study is a prospective longitudinal examination of symptoms of drug and alcohol use (SUD) and PTSD symptoms in 1006 veterans in the 6 years (T3) following return from the Persian Gulf War (PGW). Both alcohol and drug use at T3 were significantly correlated with demographic variables and all three types of PTSD symptoms (reexperiencing, avoidance, and arousal) as measured at T2. Hierarchical regressions were conducted to examine the self-medication hypothesis, which was supported for drug use but not for alcohol use at T3. JF - Addictive behaviors AU - Shipherd, Jillian C AU - Stafford, Jane AU - Tanner, Lynlee R AD - Boston University School of Medicine, USA. Jillian.Shipherd@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 595 EP - 599 VL - 30 IS - 3 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Marital Status KW - Educational Status KW - Prospective Studies KW - Humans KW - Adult KW - Longitudinal Studies KW - Male KW - Female KW - Gulf War KW - Stress Disorders, Post-Traumatic -- psychology KW - Stress Disorders, Post-Traumatic -- complications KW - Substance-Related Disorders -- etiology KW - Veterans -- psychology KW - Alcohol Drinking -- psychology KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67436293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Predicting+alcohol+and+drug+abuse+in+Persian+Gulf+War+veterans%3A+what+role+do+PTSD+symptoms+play%3F&rft.au=Shipherd%2C+Jillian+C%3BStafford%2C+Jane%3BTanner%2C+Lynlee+R&rft.aulast=Shipherd&rft.aufirst=Jillian&rft.date=2005-03-01&rft.volume=30&rft.issue=3&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-13 N1 - Date created - 2005-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tolerability and effectiveness of lamotrigine in complex elderly patients. AN - 67392165; 15681622 AB - There is paucity of medical literature on the use of lamotrigine in elderly patients who have behavior problems and diverse psychiatric syndromes. This article is a retrospective case series summarizing the authors' experience with this medication. In a 20-patient case series from an institutional review board-approved retrospective chart review, the tolerability and efficacy of lamotrigine was evaluated for the management of agitated and aggressive behaviors in nursing home patients with a range of psychiatric and medical diagnoses. Nineteen of the elderly nursing home patients tolerated lamotrigine treatment, and 18 showed modest clinical improvement. These results support the authors' belief that controlled clinical investigations of this medication should be performed. JF - Journal of geriatric psychiatry and neurology AU - Aulakh, Jasdeep S AU - Hawkins, James W AU - Athwal, Herman S AU - Sheikh, Javaid I AU - Yesavage, Jerome AU - Tinklenberg, Jared R AD - VA Palo Alto Health Care System and Mental Illness Research, Educational and Clinical Center and Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Menlo Park, CA 94025, USA. jasdeep.aulakh@med.va.gov Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 8 EP - 11 VL - 18 IS - 1 SN - 0891-9887, 0891-9887 KW - Antimanic Agents KW - 0 KW - Triazines KW - lamotrigine KW - U3H27498KS KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Treatment Outcome KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Mental Disorders -- drug therapy KW - Aging -- psychology KW - Antimanic Agents -- adverse effects KW - Antimanic Agents -- therapeutic use KW - Triazines -- adverse effects KW - Triazines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67392165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+geriatric+psychiatry+and+neurology&rft.atitle=Tolerability+and+effectiveness+of+lamotrigine+in+complex+elderly+patients.&rft.au=Aulakh%2C+Jasdeep+S%3BHawkins%2C+James+W%3BAthwal%2C+Herman+S%3BSheikh%2C+Javaid+I%3BYesavage%2C+Jerome%3BTinklenberg%2C+Jared+R&rft.aulast=Aulakh&rft.aufirst=Jasdeep&rft.date=2005-03-01&rft.volume=18&rft.issue=1&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Journal+of+geriatric+psychiatry+and+neurology&rft.issn=08919887&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-12 N1 - Date created - 2005-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Obesity prevalence among veterans at Veterans Affairs medical facilities AN - 19659207; 8790826 AB - Abstract not available. JF - American Journal of Preventive Medicine AU - Das, Sandeep R AU - Kinsinger, Linda S AU - Yancy Jr, William S AU - Wang, Anthea AU - Ciesco, Eileen AU - Burdick, Mary AU - Yevich, Steven J AD - Preventive Medicine Residency Program, Department of Social Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Linda.Kinsinger@med.va.gov Y1 - 2005/03// PY - 2005 DA - Mar 2005 SP - 291 EP - 294 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 28 IS - 3 SN - 0749-3797, 0749-3797 KW - Physical Education Index KW - Obesity KW - Facilities KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19659207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Obesity+prevalence+among+veterans+at+Veterans+Affairs+medical+facilities&rft.au=Das%2C+Sandeep+R%3BKinsinger%2C+Linda+S%3BYancy+Jr%2C+William+S%3BWang%2C+Anthea%3BCiesco%2C+Eileen%3BBurdick%2C+Mary%3BYevich%2C+Steven+J&rft.aulast=Das&rft.aufirst=Sandeep&rft.date=2005-03-01&rft.volume=28&rft.issue=3&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2004.12.007 LA - English DB - Physical Education Index N1 - Date revised - 2009-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obesity; Facilities DO - http://dx.doi.org/10.1016/j.amepre.2004.12.007 ER - TY - JOUR T1 - The Role of Sexual Assault on the Risk of PTSD among Gulf War Veterans AN - 17811149; 6220626 AB - The 1991 Gulf War was the first major military deployment where female troops were integrated into almost every military unit, except for combat ground units. We evaluated the impact of reported sexual trauma during this deployment on the risk of post-traumatic stress disorder (PTSD) after the war. A nested case-control analysis was conducted using the data collected in a population-based health survey of 30,000 Gulf War era veterans. A total of 1381 Gulf War veterans with current PTSD were compared with 10,060 Gulf veteran controls without PTSD for self-reported in-theater experiences of sexual harassment/assault and combat exposure. The adjusted odds ratio (aOR) for PTSD associated with a report of sexual assault was 5.41 (95% confidence interval [CI], 3.19-9.17) in female veterans and 6.21 (95% CI, 2.26-17.04) in male veterans. The aOR for PTSD associated with "high" combat exposure was also statistically significant (aOR, 4.03 [95% CI, 1.97-8.23] for females; aOR, 4.45 [95% CI, 3.54-5.60] for males). Notwithstanding a possibility of recall bias of combat and sexual trauma, for both men and women, sexual trauma as well as combat exposure appear to be strong risk factors for PTSD. JF - Annals of Epidemiology AU - Kang, Han AU - Dalager, N AU - Mahan, C AU - Ishii, E AD - Environmental Epidemiology Service (135), Department of Veterans Affairs, 810 Vermont Ave., N.W., Washington, DC 20420, USA, han.kang@hq.med.va.gov Y1 - 2005/03// PY - 2005 DA - Mar 2005 SP - 191 EP - 195 VL - 15 IS - 3 SN - 1047-2797, 1047-2797 KW - Gulf War KW - Risk Abstracts; Health & Safety Science Abstracts KW - Occupational safety KW - Sexual assault KW - Posttraumatic stress disorder KW - Females KW - Military KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17811149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=The+Role+of+Sexual+Assault+on+the+Risk+of+PTSD+among+Gulf+War+Veterans&rft.au=Kang%2C+Han%3BDalager%2C+N%3BMahan%2C+C%3BIshii%2C+E&rft.aulast=Kang&rft.aufirst=Han&rft.date=2005-03-01&rft.volume=15&rft.issue=3&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2004.05.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Military; Females; Occupational safety; Sexual assault; Posttraumatic stress disorder DO - http://dx.doi.org/10.1016/j.annepidem.2004.05.009 ER - TY - JOUR T1 - In Vitro Activity of Structurally Diverse Nucleoside Analogs against Human Immunodeficiency Virus Type 1 with the K65R Mutation in Reverse Transcriptase AN - 17805389; 6164287 AB - Human immunodeficiency virus type 1 (HIV-1) with a lysine-to-arginine substitution at codon 65 (HIV-1 sub(65R)) of reverse transcriptase (RT) can rapidly emerge in patients being treated with specific combinations of nucleoside analog RT inhibitors (NRTIs). A better understanding of the activity of approved and investigational NRTIs against HIV-1 sub(65R) is needed to select optimal therapy for patients infected with this mutant and to devise strategies to prevent its emergence. Therefore, we tested a broad panel of NRTIs that differed by enantiomer, pseudosugar, and base component against HIV-1 sub(65R) to determine how NRTI structure affects activity. Drug susceptibilities of recombinant wild-type (HIV-1 sub(65K)) or mutant HIV-1 sub(65R) were determined using a single-replication-cycle susceptibility assay with P4/R5 cells and/or a multiple-replication-cycle susceptibility assay with MT-2 cells. All D, L, and acyclic NRTIs were significantly less active against HIV-1 sub(65R) than against HIV-1 sub(65K) except for analogs containing a 3'-azido moiety. Pseudosugar structure and base component but not enantiomer influenced NRTI activity against HIV-1 sub(65R). These findings support the inclusion of 3'-azido-3'-deoxythymidine in drug combinations to treat patients having HIV-1 sub(65R) and to prevent its emergence. JF - Antimicrobial Agents & Chemotherapy AU - Parikh, Urvi M AU - Koontz, Dianna L AU - Chu, Chung K AU - Schinazi, Raymond F AU - Mellors, John W AD - Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. College of Pharmacy, University of Georgia, Athens. Laboratory of Biochemical Pharmacology, Center for AIDS Research, Department of Pediatrics, Emory University School of Medicine/Veterans Administration Medical Center, Decatur, Georgia Y1 - 2005/03// PY - 2005 DA - Mar 2005 SP - 1139 EP - 1144 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 49 IS - 3 SN - 0066-4804, 0066-4804 KW - HIV-1 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Antimicrobial agents KW - nucleoside analogs KW - Antiviral agents KW - Enantiomers KW - Human immunodeficiency virus 1 KW - Codons KW - RNA-directed DNA polymerase KW - Mutation KW - V 22002:AIDS: Molecular and in vitro aspects KW - A 01068:Antiviral & viricidal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17805389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+Vitro+Activity+of+Structurally+Diverse+Nucleoside+Analogs+against+Human+Immunodeficiency+Virus+Type+1+with+the+K65R+Mutation+in+Reverse+Transcriptase&rft.au=Parikh%2C+Urvi+M%3BKoontz%2C+Dianna+L%3BChu%2C+Chung+K%3BSchinazi%2C+Raymond+F%3BMellors%2C+John+W&rft.aulast=Parikh&rft.aufirst=Urvi&rft.date=2005-03-01&rft.volume=49&rft.issue=3&rft.spage=1139&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus 1; Enantiomers; RNA-directed DNA polymerase; nucleoside analogs; Antiviral agents; Codons; Mutation; Antimicrobial agents ER - TY - JOUR T1 - The Cooperative Outcomes Group for ENT: a multicenter prospective cohort study on the outcomes of tympanostomy tubes for children with otitis media. AN - 85374763; pmid-15692524 AB - Outcomes for patients with otitis media were assessed in this prospective, multicenter study.Thirty-one otolaryngologists enrolled 272 pediatric patients with otitis media; caregivers completed surveys at 3-month intervals, and clinical and treatment data was also collected. The Otitis Media 6 (OM-6) was the primary outcome measure.One hundred seventy-seven patients (mean age 2.0 years) completed 3-month follow-up. One hundred thirty-seven patients underwent tympanostomy tube placement. Large improvements in disease-specific quality of life (QOL) were seen up to 9 months of follow-up. Baseline OM-6 score was the best predictor of clinical success in regression modeling.Patients referred to an otolaryngologist for treatment of otitis media see large improvements in disease-specific QOL regardless of treatment rendered.The study demonstrates the feasibility of multicenter outcomes studies and confirms appropriate triage of patients with otitis media into surgical versus medical interventions. EBM rating: C. JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery AU - Witsell, David L AU - Stewart, Michael G AU - Monsell, Edwin M AU - Hadley, James A AU - Terrell, Jeffrey E AU - Yueh, Bevan AU - Rosenfeld, Richard M AU - Hannley, Maureen T AU - Holzer, Susan Sedory AD - Duke University Medical Center, Divison of Otolaryngology-Head and Neck Surgery, Durham Veterans Administration Medical Center, NC 27710, USA. witse001@mc.duke.edu Y1 - 2005/02// PY - 2005 DA - Feb 2005 SP - 180 EP - 188 VL - 132 IS - 2 SN - 0194-5998, 0194-5998 KW - Index Medicus KW - National Library of Medicine KW - Child KW - Child, Preschool KW - Female KW - Follow-Up Studies KW - Health Surveys KW - Humans KW - Infant KW - Male KW - *Middle Ear Ventilation KW - *Otitis Media: surgery KW - Prospective Studies KW - Quality of Life KW - Socioeconomic Factors KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85374763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=The+Cooperative+Outcomes+Group+for+ENT%3A+a+multicenter+prospective+cohort+study+on+the+outcomes+of+tympanostomy+tubes+for+children+with+otitis+media.&rft.au=Witsell%2C+David+L%3BStewart%2C+Michael+G%3BMonsell%2C+Edwin+M%3BHadley%2C+James+A%3BTerrell%2C+Jeffrey+E%3BYueh%2C+Bevan%3BRosenfeld%2C+Richard+M%3BHannley%2C+Maureen+T%3BHolzer%2C+Susan+Sedory&rft.aulast=Witsell&rft.aufirst=David&rft.date=2005-02-01&rft.volume=132&rft.issue=2&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Modulation Enhancement of Speech by a Pre-Processing Algorithm for Improving Intelligibility in Reverberant Environments AN - 85332503; llba-200504930 AB - Most listeners have difficulty understanding speech in reverberant conditions. The purpose of this study is to investigate whether it is possible to reduce the degree of degradation of speech intelligibility in reverberation through the development of an algorithm. The modulation spectrum is the spectral representation of the temporal envelope of the speech signal. That of clean speech is dominated by components between 1 & 16 Hz centered at 4 Hz which is the most important range for human perception of speech. In reverberant conditions, the modulation spectrum of speech is shifted toward the lower end of the modulation frequency range. In this study, we proposed to enhance the important modulation spectral components prior to distortion of speech by reverberation. Word intelligibility in a carrier sentence was tested with the newly developed algorithm including two different filter designs in three reverberant conditions. The reverberant speech was simulated by convoluting clean speech with impulse responses measured in the actual halls. The experimental results show that modulation filtering incorporated into a pre-processing algorithm improves intelligibility for normal hearing listeners when (1) the modulation filters are optimal for a specific reverberant condition (i.e., T60 = 1.1 s), & (2) consonants are preceded by highly powered segments. Under shorter (0.7 s) & longer (1.6 s) reverberation times, the modulation filtering in the current experiments, an Empirically-Designed (E-D) filter & a Data-Derived (D-D) filter, caused a slight performance decrement respectively. The results of this study suggest that further gains in intelligibility may be accomplished by re-design of the modulation filters suitable for other reverberant conditions. 2 Tables, 8 Figures, 35 References. [Copyright 2004 Elsevier B.V.] JF - Speech Communication AU - Kusumoto, Akiko AU - Arai, Takayuki AU - Kinoshita, Keisuke AU - Hodoshima, Nao AU - Vaughan, Nancy AD - VA RR&D National Center Rehabilitative Auditory Research, Portland VA Medical Center, NCRAR, OR akiko.kusumoto@med.va.gov Y1 - 2005/02// PY - 2005 DA - Feb 2005 SP - 101 EP - 113 VL - 45 IS - 2 SN - 0167-6393, 0167-6393 KW - *Frequency (Acoustics) (26100) KW - *Distortion of Speech Signal (19650) KW - *Noise (58100) KW - *Speech Perception (82700) KW - *Auditory Thresholds (06150) KW - *Consonants (14900) KW - *Word Recognition (98200) KW - *Intelligibility (36600) KW - article KW - 4017: psycholinguistics; psychoacoustics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85332503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Speech+Communication&rft.atitle=Modulation+Enhancement+of+Speech+by+a+Pre-Processing+Algorithm+for+Improving+Intelligibility+in+Reverberant+Environments&rft.au=Kusumoto%2C+Akiko%3BArai%2C+Takayuki%3BKinoshita%2C+Keisuke%3BHodoshima%2C+Nao%3BVaughan%2C+Nancy&rft.aulast=Kusumoto&rft.aufirst=Akiko&rft.date=2005-02-01&rft.volume=45&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Speech+Communication&rft.issn=01676393&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2005-05-01 N1 - Last updated - 2014-06-17 N1 - CODEN - SCOMDH N1 - SubjectsTermNotLitGenreText - *Speech Perception (82700); *Intelligibility (36600); *Distortion of Speech Signal (19650); *Frequency (Acoustics) (26100); *Auditory Thresholds (06150); *Noise (58100); *Word Recognition (98200); *Consonants (14900) ER - TY - JOUR T1 - Consistency of retrospective reports of DSM-IV criterion A traumatic stressors among substance use disorder patients. AN - 68805909; 16281195 AB - Posttraumatic stress disorder (PTSD) is prevalent among substance use disorder (SUD) patients. Although Criterion A trauma is critical to the formulation of a PTSD diagnosis, little research has examined the reliability of retrospective reports of such stressors and factors that affect reporting among these patients. This study examined these issues among SUD patients. Participants (N = 120) were assessed by interviews and questionnaires after entering inpatient SUD treatment and at a 6-month follow-up. About 40% of participants met criteria for a current PTSD diagnosis. Results revealed moderate stability of Criterion A trauma reports, which improved when Criterion A requirements were relaxed (i.e., participants were required to report the stressor but not the Criteria A1 and A2). Intrusive symptoms were associated with increased stressor reporting over time, whereas numbing symptoms and SUD abstinence were associated with decreased stressor reporting over time. Dissociative symptoms were associated with changes in reporting in either direction. JF - Journal of traumatic stress AU - Ouimette, Paige AU - Read, Jennifer AU - Brown, Pamela J AD - Washington Institute for Mental Illness Research and Training, Washington State University, Spokane, Washington, USA. paigec.ouimette@med.va.gov Y1 - 2005/02// PY - 2005 DA - February 2005 SP - 43 EP - 51 VL - 18 IS - 1 SN - 0894-9867, 0894-9867 KW - Index Medicus KW - Reproducibility of Results KW - Humans KW - Stress, Psychological KW - Adult KW - Wounds and Injuries KW - Retrospective Studies KW - Middle Aged KW - Male KW - Female KW - Diagnostic and Statistical Manual of Mental Disorders KW - Stress Disorders, Post-Traumatic -- etiology KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Substance-Related Disorders -- complications KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68805909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+traumatic+stress&rft.atitle=Consistency+of+retrospective+reports+of+DSM-IV+criterion+A+traumatic+stressors+among+substance+use+disorder+patients.&rft.au=Ouimette%2C+Paige%3BRead%2C+Jennifer%3BBrown%2C+Pamela+J&rft.aulast=Ouimette&rft.aufirst=Paige&rft.date=2005-02-01&rft.volume=18&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Journal+of+traumatic+stress&rft.issn=08949867&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cutaneous hyperpigmentation due to chronic quinine ingestion. AN - 67519903; 15773532 AB - Striking hyperpigmentation developed on the arms of a 66-year-old man following protracted oral ingestion of quinine. Although this phenomenon is well described in conjunction with other similar drugs, including quinidine, it has not been well documented following exposure to quinine. This adverse event is cosmetic in nature and is not associated with functional impairment. JF - Cutis AU - Rosen, Ted AU - Aponte, Carol AD - Department of Dermatology, Baylor College of Medicine and Veterans Administration Medical Center, Houston, Texas, USA. tedrosenmd@aol.com Y1 - 2005/02// PY - 2005 DA - February 2005 SP - 114 EP - 116 VL - 75 IS - 2 SN - 0011-4162, 0011-4162 KW - Quinine KW - A7V27PHC7A KW - Index Medicus KW - Severity of Illness Index KW - Upper Extremity KW - Dose-Response Relationship, Drug KW - Humans KW - Aged KW - Follow-Up Studies KW - Time Factors KW - Male KW - Risk Assessment KW - Quinine -- adverse effects KW - Quinine -- therapeutic use KW - Hyperpigmentation -- pathology KW - Hyperpigmentation -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67519903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cutis&rft.atitle=Cutaneous+hyperpigmentation+due+to+chronic+quinine+ingestion.&rft.au=Rosen%2C+Ted%3BAponte%2C+Carol&rft.aulast=Rosen&rft.aufirst=Ted&rft.date=2005-02-01&rft.volume=75&rft.issue=2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Cutis&rft.issn=00114162&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-28 N1 - Date created - 2005-03-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment of chronic hepatitis C in human immunodeficiency virus/hepatitis C virus-coinfected patients in the era of pegylated interferon and ribavirin. AN - 67460475; 15731996 AB - A significant percentage of human immunodeficiency virus (HIV) -infected individuals are also infected with the hepatitis C virus (HCV). With the much-improved survival of HIV-infected patients through the use of highly active antiretroviral therapy, liver disease caused by coinfection with HCV has emerged as a significant threat to the health and survival of persons with HIV disease. HIV/HCV-coinfected patients with ongoing HIV viremia have a faster rate of HCV-related liver fibrosis progression and a more rapid progression to liver failure or hepatocellular carcinoma than HCV-monoinfected persons. In contrast to the deleterious effect of HIV on HCV-related liver disease, most studies have shown that HCV does not influence progression of HIV infection to AIDS or death. HCV therapy with peginterferon alfa (2a or 2b) plus ribavirin can achieve a sustained viral response in HIV/HCV-coinfected patients of up to 38% in HCV genotype 1 and up to 73% in genotypes 2 and 3. The safety profile is largely similar to therapy in HIV-monoinfected patients, but there is a higher incidence of mitochondrial toxicity in patients taking didanosine or stavudine and of anemia in patients taking zidovudine. There is no proven anti-HCV therapy for HIV/HCV-coinfected patients with end-stage liver disease (ESLD). Liver transplantation is being investigated as a potential therapeutic option for HIV-infected individuals with ESLD, and initial reports are encouraging. Given that pegylated interferon and ribavirin have been shown to be safe and effective for HIV/HCV coinfection as well as HCV monoinfection, all HIV/HCV-coinfected patients should be evaluated for therapy. JF - Seminars in liver disease AU - Bräu, Norbert AD - Mount Sinai School of Medicine, Bronx Veterans Affairs Medical Center, Infectious Diseases Section (111F), 130 West Kingsbridge Road, New York, NY 0468, USA. norbert.brau@med.va.gov Y1 - 2005/02// PY - 2005 DA - February 2005 SP - 33 EP - 51 VL - 25 IS - 1 SN - 0272-8087, 0272-8087 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - Recombinant Proteins KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2b KW - 43K1W2T1M6 KW - interferon alfa-2a KW - 47RRR83SK7 KW - Ribavirin KW - 49717AWG6K KW - peginterferon alfa-2b KW - G8RGG88B68 KW - peginterferon alfa-2a KW - Q46947FE7K KW - Index Medicus KW - Drug Therapy, Combination KW - Humans KW - Treatment Outcome KW - Antiviral Agents -- therapeutic use KW - Ribavirin -- therapeutic use KW - Interferon-alpha -- therapeutic use KW - HIV Infections -- complications KW - Polyethylene Glycols -- therapeutic use KW - Hepatitis C, Chronic -- drug therapy KW - Hepatitis C, Chronic -- complications KW - HIV Infections -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67460475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+liver+disease&rft.atitle=Treatment+of+chronic+hepatitis+C+in+human+immunodeficiency+virus%2Fhepatitis+C+virus-coinfected+patients+in+the+era+of+pegylated+interferon+and+ribavirin.&rft.au=Br%C3%A4u%2C+Norbert&rft.aulast=Br%C3%A4u&rft.aufirst=Norbert&rft.date=2005-02-01&rft.volume=25&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Seminars+in+liver+disease&rft.issn=02728087&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-23 N1 - Date created - 2005-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of high-dose selegiline on morphine reinforcement and precipitated withdrawal in dependent rats. AN - 67423382; 15706133 AB - Selegiline is an irreversible inhibitor of monoamine oxidase (MAO) with psychostimulant and neuroprotective effects. Several lines of evidence suggest that treatment with selegiline at doses that exceed levels required for inhibition of MAO can produce distinct pharmacologic effects. The purpose of this study was to evaluate the effects of chronic treatment with high-dose selegiline on extinction responding, cue-induced reinstatement, morphine reinforcement and naloxone-precipitated withdrawal. After pretreatment with noncontingent morphine to establish opiate dependence, rats acquired self-administration of 3.2 mg/kg per injection of morphine under a progressive ratio schedule. Daily treatment with saline or 6.4 mg/kg per day of selegiline was then administered over extinction, reinstatement and re-acquisition of morphine self-administration. To enhance or diminish the potential for psychostimulant effects, selegiline was administered either immediately prior to (pre-session) or 1 h following (post-session) extinction, reinstatement and self-administration sessions. Pre-session selegiline decreased the number of ratios completed on days 2, 3 and 4 of extinction, and decreased morphine self-administration during all four re-acquisition sessions. When administered at the same dose level, post-session selegiline decreased responding on the fourth extinction session, and was ineffective in modifying re-acquisition of self-administration. Selegiline administered by either schedule did not modify cue-induced reinstatement. Daily treatment with 6.4 mg/kg per day of selegiline did not modify self-administration of food under a progressive ratio schedule. Acute treatment with single, 6.4 mg/kg doses of selegiline attenuated naloxone-induced increases in ptosis and global withdrawal score, but did not modify any other sign of withdrawal or global withdrawal score calculated without ratings of ptosis. In conclusion, high-dose selegiline can attenuate extinction responding and morphine-reinforced behavior, and these effects may be mediated by psychostimulant metabolites. JF - Behavioural pharmacology AU - Grasing, K AU - He, S AD - Substance Abuse Research Laboratory, Kansas City Veterans Affairs Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA. kenneth.grasing@med.va.gov Y1 - 2005/02// PY - 2005 DA - February 2005 SP - 1 EP - 13 VL - 16 IS - 1 SN - 0955-8810, 0955-8810 KW - Analgesics, Opioid KW - 0 KW - Monoamine Oxidase Inhibitors KW - Narcotic Antagonists KW - Selegiline KW - 2K1V7GP655 KW - Naloxone KW - 36B82AMQ7N KW - Morphine KW - 76I7G6D29C KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Naloxone -- pharmacology KW - Reinforcement Schedule KW - Reinforcement (Psychology) KW - Dopamine -- physiology KW - Eating KW - Rats KW - Photic Stimulation KW - Self Administration KW - Cues KW - Rats, Wistar KW - Acoustic Stimulation KW - Motor Activity -- drug effects KW - Narcotic Antagonists -- pharmacology KW - Male KW - Conditioning, Operant -- drug effects KW - Selegiline -- pharmacology KW - Morphine -- adverse effects KW - Substance Withdrawal Syndrome -- psychology KW - Morphine Dependence -- psychology KW - Analgesics, Opioid -- adverse effects KW - Monoamine Oxidase Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67423382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+pharmacology&rft.atitle=Effects+of+high-dose+selegiline+on+morphine+reinforcement+and+precipitated+withdrawal+in+dependent+rats.&rft.au=Grasing%2C+K%3BHe%2C+S&rft.aulast=Grasing&rft.aufirst=K&rft.date=2005-02-01&rft.volume=16&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Behavioural+pharmacology&rft.issn=09558810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-24 N1 - Date created - 2005-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methotrexate reduces incidence of vascular diseases in veterans with psoriasis or rheumatoid arthritis. AN - 67400367; 15692471 AB - Methotrexate (MTX) is a folate analogue used in the treatment of moderate to severe psoriasis and rheumatoid arthritis (RA). It oppositely affects inflammation and hyperhomocysteinemia-two independent risk factors for vascular disease. To date, there are no published reports evaluating the impact of these potentially paradoxical action of MTX. The purpose of this study was to evaluate the effect of MTX therapy on the incidence of vascular disease in patients with psoriasis and RA. We conducted a retrospective cohort study in which we analyzed computerized records of 7,615 outpatients diagnosed with psoriasis and 6,707 with RA at the Veterans Integrated Service Network 8. Patients prescribed MTX therapy had a significantly reduced risk of vascular disease compared to those who were not prescribed MTX (psoriasis: RR = 0.73, 95% CI = 0.55-0.98; RA: 0.83, 0.71-0.96). This reduction was most evident for patients prescribed a low cumulative dose of MTX (psoriasis: RR = 0.50, 95% CI = 0.31-0.79; RA = 0.65, 0.52-0.80). Concomitant use of folic acid (FA) with MTX also reduced the incidence of vascular disease in patients prescribed MTX (psoriasis: RR = 0.56, 95% CI = 0.39-0.80; RA: 0.77, 0.38-1.56). MTX therapy reduced the incidence of vascular disease in veterans with psoriasis or RA. Low to moderate cumulative dose appears more beneficial than the higher dose. We hypothesize that this effect is caused by its anti-inflammatory properties. In addition, a combination of MTX and FA led to a further reduction in the incidence of vascular disease. JF - Journal of the American Academy of Dermatology AU - Prodanovich, Srdjan AU - Prodanowich, Srdjan AU - Ma, Fangchao AU - Taylor, J Richard AU - Pezon, Candido AU - Fasihi, Tahira AU - Kirsner, Robert S AD - Department of Dermatology, Veterans Administration Medical Center, Miami, Florida 33125, USA. Y1 - 2005/02// PY - 2005 DA - February 2005 SP - 262 EP - 267 VL - 52 IS - 2 KW - Immunosuppressive Agents KW - 0 KW - Folic Acid KW - 935E97BOY8 KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Medical Records Systems, Computerized KW - Hyperhomocysteinemia -- prevention & control KW - Humans KW - Retrospective Studies KW - Aged KW - Folic Acid -- therapeutic use KW - Hyperhomocysteinemia -- chemically induced KW - Comorbidity KW - Florida -- epidemiology KW - Folic Acid -- administration & dosage KW - Veterans KW - Drug Therapy, Combination KW - Risk KW - Cohort Studies KW - Databases, Factual KW - Incidence KW - Middle Aged KW - Drug Synergism KW - Male KW - Female KW - Arthritis, Rheumatoid -- drug therapy KW - Psoriasis -- complications KW - Vascular Diseases -- epidemiology KW - Vascular Diseases -- complications KW - Methotrexate -- adverse effects KW - Vascular Diseases -- prevention & control KW - Methotrexate -- therapeutic use KW - Psoriasis -- drug therapy KW - Immunosuppressive Agents -- therapeutic use KW - Methotrexate -- administration & dosage KW - Arthritis, Rheumatoid -- complications KW - Immunosuppressive Agents -- administration & dosage KW - Immunosuppressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67400367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Methotrexate+reduces+incidence+of+vascular+diseases+in+veterans+with+psoriasis+or+rheumatoid+arthritis.&rft.au=Prodanovich%2C+Srdjan%3BProdanowich%2C+Srdjan%3BMa%2C+Fangchao%3BTaylor%2C+J+Richard%3BPezon%2C+Candido%3BFasihi%2C+Tahira%3BKirsner%2C+Robert+S&rft.aulast=Prodanovich&rft.aufirst=Srdjan&rft.date=2005-02-01&rft.volume=52&rft.issue=2&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=1097-6787&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-16 N1 - Date created - 2005-02-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Am Acad Dermatol. 2005 Apr;52(4):670 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - More on Monsel's solution... AN - 67387020; 15674215 JF - Surgery AU - Shuhaiber, Jeffrey H AU - Lipnick, Stuart AU - Teresi, Miguel AU - Molinari, Michele AU - Ryoo, Jei AU - Cintron, Jose AD - Department of Surgery, West Side Veterans Administration, and University of Illinois at Chicago, 840 Southwood Street, Chicago, IL 60612, USA. shuhaibr@uic.edu Y1 - 2005/02// PY - 2005 DA - February 2005 SP - 263 EP - 264 VL - 137 IS - 2 SN - 0039-6060, 0039-6060 KW - Ferric Compounds KW - 0 KW - Hemostatics KW - Sulfates KW - ferric subsulfate solution KW - 3QJ8WS6V8H KW - Abridged Index Medicus KW - Index Medicus KW - Necrosis KW - Jejunum -- injuries KW - Jejunum -- drug effects KW - Cervical Intraepithelial Neoplasia -- surgery KW - Humans KW - Uterine Cervical Neoplasms -- surgery KW - Middle Aged KW - Blood Loss, Surgical KW - Biopsy KW - Female KW - Jejunum -- pathology KW - Ferric Compounds -- adverse effects KW - Hemostasis, Surgical -- adverse effects KW - Hemostatics -- adverse effects KW - Sulfates -- adverse effects KW - Hemostasis, Surgical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67387020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Surgery&rft.atitle=More+on+Monsel%27s+solution...&rft.au=Shuhaiber%2C+Jeffrey+H%3BLipnick%2C+Stuart%3BTeresi%2C+Miguel%3BMolinari%2C+Michele%3BRyoo%2C+Jei%3BCintron%2C+Jose&rft.aulast=Shuhaiber&rft.aufirst=Jeffrey&rft.date=2005-02-01&rft.volume=137&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Surgery&rft.issn=00396060&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-03-08 N1 - Date created - 2005-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical, psychosocial, and treatment differences in minority patients with bipolar disorder. AN - 67357874; 15654937 AB - The clinical profile of minorities with bipolar disorder has been largely unexplored. We compared the clinical (e.g. psychiatric and substance use comorbidity), psychosocial, and treatment characteristics between white and minority patients with bipolar disorder (minorities were defined as black or other minority, which included Hispanic, Asian-American, or Native-Americans). We collected demographic, diagnosis, and treatment information using the Structured Clinical Interview for DSM-IV (SCID) from 330 inpatients with a current major affective episode across 11 Veterans Affairs (VA) Medical Centers enrolled in the VA Cooperative Study (Reducing the Efficacy-Effectiveness Gap in Bipolar Disorder). Twenty-four percent (n=80) were minority; 9% (n=30) were women, 4% (n=20) were >or=65 years old; and the majority (87%, n=286) had bipolar type I. Minorities compared with whites were no more likely to have a current episode of psychosis (30% versus 37%, respectively; p=0.28). However, minorities were more likely than whites to have a cocaine use disorder (adjusted odd's ratio, OR=2.2; 95% CI: 1.4-3.5; p<0.01) or current alcohol abuse disorder (adjusted OR=1.8; 95% CI: 1.1-3.9;p<0.05). Further breakdown by race/ethnicity revealed that cocaine use disorder was most prevalent among blacks (n=14, 29%), compared with all other minorities (n=2, 6%) or whites (n=10, 4%; p<0.001). Other minorities compared with blacks or whites were more likely involuntarily committed during some part of their index hospitalization (adjusted OR=2.47; 95% CI: 1.1-5.7; p=0.04). Minorities with bipolar disorder may be a more vulnerable population because of higher rates of substance use disorder and higher rates of involuntary psychiatric commitment. Moreover, the specific profile of vulnerability may differ across minority groups. Copyright (c) 2005, Blackwell Munksgaard. JF - Bipolar disorders AU - Kilbourne, Amy M AU - Bauer, Mark S AU - Pincus, Harold AU - Williford, William O AU - Kirk, Gail F AU - Beresford, Thomas AU - Veterans Administration (VA) Cooperative Study #430 Team AD - Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15240, USA. amy.kilbourne@med.va.gov ; Veterans Administration (VA) Cooperative Study #430 Team Y1 - 2005/02// PY - 2005 DA - February 2005 SP - 89 EP - 97 VL - 7 IS - 1 SN - 1398-5647, 1398-5647 KW - Index Medicus KW - Psychology KW - Humans KW - African Americans -- statistics & numerical data KW - Indians, North American -- statistics & numerical data KW - Comorbidity KW - Hispanic Americans -- statistics & numerical data KW - Interview, Psychological KW - Alcoholism -- epidemiology KW - Risk Factors KW - Adult KW - Middle Aged KW - Asian Americans -- statistics & numerical data KW - Female KW - Male KW - Minority Groups KW - Bipolar Disorder -- ethnology KW - Bipolar Disorder -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67357874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bipolar+disorders&rft.atitle=Clinical%2C+psychosocial%2C+and+treatment+differences+in+minority+patients+with+bipolar+disorder.&rft.au=Kilbourne%2C+Amy+M%3BBauer%2C+Mark+S%3BPincus%2C+Harold%3BWilliford%2C+William+O%3BKirk%2C+Gail+F%3BBeresford%2C+Thomas%3B430+Team&rft.aulast=Kilbourne&rft.aufirst=Amy&rft.date=2005-02-01&rft.volume=7&rft.issue=1&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Bipolar+disorders&rft.issn=13985647&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-10 N1 - Date created - 2005-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Practical considerations in the assessment and treatment of pain in adults with physical disabilities. AN - 67262648; 15561545 AB - Adults aging with physical disabilities experience a variety of pain disorders that affect their functionality and QOL. It is important that clinicians caring for this population be knowledgeable about this common symptom and be able to perform a thorough history and physical examination. In addition, it is imperative to have a good working knowledge of the strengths and limitations of the treatments available. JF - Physical medicine and rehabilitation clinics of North America AU - Cristian, Adrian AU - Thomas, Jodi AU - Nisenbaum, Michelle AU - Jeu, Lilyann AD - Department of Rehabilitation Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA. adrian.cristian@med.va.gov Y1 - 2005/02// PY - 2005 DA - February 2005 SP - 57 EP - 90 VL - 16 IS - 1 SN - 1047-9651, 1047-9651 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Antidepressive Agents, Tricyclic KW - Cyclooxygenase Inhibitors KW - Narcotics KW - Index Medicus KW - Injections, Intra-Articular KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Exercise Therapy KW - Cryotherapy KW - Humans KW - Antidepressive Agents, Tricyclic -- therapeutic use KW - Kidney -- drug effects KW - Platelet Aggregation -- drug effects KW - Comorbidity KW - Cyclooxygenase Inhibitors -- adverse effects KW - Cyclooxygenase Inhibitors -- therapeutic use KW - Liver -- drug effects KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Narcotics -- therapeutic use KW - Massage KW - Pain -- drug therapy KW - Pain -- epidemiology KW - Disabled Persons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67262648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physical+medicine+and+rehabilitation+clinics+of+North+America&rft.atitle=Practical+considerations+in+the+assessment+and+treatment+of+pain+in+adults+with+physical+disabilities.&rft.au=Cristian%2C+Adrian%3BThomas%2C+Jodi%3BNisenbaum%2C+Michelle%3BJeu%2C+Lilyann&rft.aulast=Cristian&rft.aufirst=Adrian&rft.date=2005-02-01&rft.volume=16&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Physical+medicine+and+rehabilitation+clinics+of+North+America&rft.issn=10479651&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-03-02 N1 - Date created - 2004-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of cirrhosis on antibiotic efficacy in a rat model of pneumococcal pneumonia AN - 17800804; 6150037 AB - A rat model was used to study the effects of cirrhosis on antibiotic therapy of pneumococcal pneumonia. Cirrhotic and control male Sprague-Dawley rats were infected transtracheally with type 3 Streptococcus pneumoniae. Treatment began 18 h later with phosphate-buffered saline (PBS), azithromycin (50 mg/kg), trovafloxacin (50 mg/kg), or ceftriaxone (100 mg/kg) injected subcutaneously twice daily for 5 days. Antibiotic concentrations were measured by high- performance liquid chromatography. Azithromycin, trovafloxacin, and ceftriaxone were all equally effective at preventing mortality in both cirrhotic and normal rats. Free fraction area under the curve to minimum inhibitory concentration ratio (AUC/MIC) and maximum calculated serum concentration to MIC ratio (C sub(max)/MIC) and percent time that the serum concentration exceeded the MIC (%T > MIC) were greater for ceftriaxone compared with azithromycin or trovafloxacin. Azithromycin achieved higher concentrations in bronchoalveolar lavage fluid (BALF), epithelial lining fluid (ELF), and BAL white blood cells than ceftriaxone or trovafloxacin in cirrhotic rats. Macrolide, beta -lactam, or fluoroquinolone antibiotic efficacy in a pneumococcal pneumonia model does not appear to be affected by hepatic cirrhosis. JF - Diagnostic Microbiology and Infectious Disease AU - Preheim, L C AU - Olsen, K M AU - Yue, M AU - Snitily, MU AU - Gentry-Nielsen, MJ AD - Infectious Diseases Section, Veterans Affairs Medical Center, Omaha, NE 68105, USA, laurel.preheim@med.va.gov Y1 - 2005/02// PY - 2005 DA - Feb 2005 SP - 103 EP - 111 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 51 IS - 2 SN - 0732-8893, 0732-8893 KW - rats KW - Microbiology Abstracts B: Bacteriology KW - Cirrhosis KW - Antibiotic efficacy KW - Pneumococcal pneumonia KW - Mortality KW - Fluoroquinolones KW - Leukocytes KW - Animal models KW - Antibiotics KW - Ceftriaxone KW - Minimum inhibitory concentration KW - Alveoli KW - Streptococcus pneumoniae KW - Trovafloxacin KW - Bronchus KW - Liquid chromatography KW - Azithromycin KW - beta -Lactam antibiotics KW - Liver KW - Pneumonia KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17800804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+Microbiology+and+Infectious+Disease&rft.atitle=Effect+of+cirrhosis+on+antibiotic+efficacy+in+a+rat+model+of+pneumococcal+pneumonia&rft.au=Preheim%2C+L+C%3BOlsen%2C+K+M%3BYue%2C+M%3BSnitily%2C+MU%3BGentry-Nielsen%2C+MJ&rft.aulast=Preheim&rft.aufirst=L&rft.date=2005-02-01&rft.volume=51&rft.issue=2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Diagnostic+Microbiology+and+Infectious+Disease&rft.issn=07328893&rft_id=info:doi/10.1016%2Fj.diagmicrobio.2004.09.008 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Mortality; Cirrhosis; Fluoroquinolones; Leukocytes; Animal models; Antibiotics; Ceftriaxone; Minimum inhibitory concentration; Alveoli; Trovafloxacin; Bronchus; Liquid chromatography; Azithromycin; beta -Lactam antibiotics; Liver; Pneumonia; Streptococcus pneumoniae DO - http://dx.doi.org/10.1016/j.diagmicrobio.2004.09.008 ER - TY - JOUR T1 - Effect of interferon-alpha on cognitive functioning in patients with chronic hepatitis C. AN - 85394788; pmid-15686604 AB - Treatment with interferon-alpha (IFN-alpha) has been shown to adversely affect cognitive functioning in patients with a variety of medical disorders, but information about the effects of IFN-alpha on cognitive functioning in patients with chronic hepatitis C (CHC) is limited. The purpose of this study was to examine the effects of IFN-alpha on neuropsychological test performance in CHC patients. Participants were 30 patients with CHC, 11 who underwent IFN-alpha therapy and 19 who did not. All participants were tested at baseline (i.e., pretreatment) and approximately 6 months later with the Symbol Digit Modalities Test and Trail Making Test. Results revealed that the treatment group performed significantly worse than untreated CHC patients on Part B of the Trail Making Test after approximately 6 months of treatment. No significant group differences were found on Part A of the Trail Making Test or Symbol Digit Modalities Test. Findings suggest that CHC patients undergoing treatment with IFN-alpha may experience reduced abilities to benefit from practice but suffer no decrements in performance after 6 months of treatment. Additional research is needed to replicate these findings and to explore risk factors for susceptibility to IFN-alpha-induced effects. JF - Journal of the International Neuropsychological Society : JINS AU - Hilsabeck, Robin C AU - Hassanein, Tarek I AU - Ziegler, Elizabeth A AU - Carlson, Meghan D AU - Perry, William AD - Department of Neuropsychiatry & Behavioral Science, Texas Tech University Health Sciences Center, Lubbock, Texas, USA. Robin.Hilsabeck@med.va.gov Y1 - 2005/01// PY - 2005 DA - Jan 2005 SP - 16 EP - 22 VL - 11 IS - 1 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - *Antiviral Agents: therapeutic use KW - *Cognition Disorders: drug therapy KW - *Cognition Disorders: etiology KW - Female KW - Hepatitis C: complications KW - *Hepatitis C: drug therapy KW - *Hepatitis C: psychology KW - Humans KW - *Immunologic Factors: therapeutic use KW - *Interferon-alpha: therapeutic use KW - Male KW - Middle Aged KW - Neuropsychological Tests KW - Psychomotor Performance: drug effects KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85394788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Effect+of+interferon-alpha+on+cognitive+functioning+in+patients+with+chronic+hepatitis+C.&rft.au=Hilsabeck%2C+Robin+C%3BHassanein%2C+Tarek+I%3BZiegler%2C+Elizabeth+A%3BCarlson%2C+Meghan+D%3BPerry%2C+William&rft.aulast=Hilsabeck&rft.aufirst=Robin&rft.date=2005-01-01&rft.volume=11&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Heavy alcohol consumption in individuals with HIV infection: effects on neuropsychological performance. AN - 85389776; pmid-15686610 AB - Higher rates of alcohol use have been reported in HIV+ individuals compared to the general population. Both heavy alcohol use and HIV infection are associated with increased risk of neuropsychological (NP) impairment. We examined effects of heavy active alcohol use and HIV on NP functioning in a large sample of community-residing HIV+ individuals and HIV- controls. The four main study groups included 72 HIV- light/non-drinkers, 70 HIV- heavy drinkers (>100 drinks per month), 70 HIV+ light/non-drinkers, and 56 HIV+ heavy drinkers. The heavy drinking group was further subdivided to assess effects of the heaviest levels of active alcohol use (>6 drinks per day) on NP functioning. A comprehensive NP battery was administered. Multivariate analysis of covariance was employed to examine the effect of HIV and alcohol on NP functioning after adjusting for group differences in age and estimated premorbid verbal intellectual functioning. The analyses identified main effects of heavy drinking and HIV on NP function, with greatest effects involving the contrast of HIV+ heavy drinkers and the HIV- light drinkers. Synergistic effects of heaviest current drinking and HIV infection were identified in analyses of motor and visuomotor speed. Supplementary analyses also revealed better NP function in the HIV+ group with antiretroviral treatment (ART) and lower level of viral burden, a finding that was consistent across levels of alcohol consumption. Finally, heavy alcohol use and executive functioning difficulties were associated with lower levels of self-reported medication adherence in the HIV+ group. The findings suggest that active heavy alcohol use and HIV infection have additive adverse effects on NP function, that they may show synergistic effects in circumstances of very heavy active alcohol use, and that heavy drinking and executive functioning may mediate health-related behaviors in HIV disease. JF - Journal of the International Neuropsychological Society : JINS AU - Rothlind, Johannes C AU - Greenfield, Tanya M AU - Bruce, Anne V AU - Meyerhoff, Dieter J AU - Flenniken, Derek L AU - Lindgren, Joselyn A AU - Weiner, Michael W AD - Mental Health Service, DVA Veterans Affairs Medical Center, San Francisco, CA 94121, USA. Johannes.Rothlind@Med.VA.Gov Y1 - 2005/01// PY - 2005 DA - Jan 2005 SP - 70 EP - 83 VL - 11 IS - 1 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Affect KW - African Americans KW - *Alcoholism: complications KW - *Alcoholism: psychology KW - Antiretroviral Therapy, Highly Active KW - CD4 Lymphocyte Count KW - Cohort Studies KW - Cross-Sectional Studies KW - Female KW - *HIV Infections: complications KW - HIV Infections: drug therapy KW - *HIV Infections: psychology KW - Hispanic Americans KW - Humans KW - Male KW - Memory, Short-Term: physiology KW - *Neuropsychological Tests KW - Patient Compliance KW - Postural Balance: physiology KW - *Psychomotor Performance: physiology KW - Space Perception: physiology KW - Substance-Related Disorders: psychology KW - Verbal Learning: physiology KW - Visual Perception: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85389776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Heavy+alcohol+consumption+in+individuals+with+HIV+infection%3A+effects+on+neuropsychological+performance.&rft.au=Rothlind%2C+Johannes+C%3BGreenfield%2C+Tanya+M%3BBruce%2C+Anne+V%3BMeyerhoff%2C+Dieter+J%3BFlenniken%2C+Derek+L%3BLindgren%2C+Joselyn+A%3BWeiner%2C+Michael+W&rft.aulast=Rothlind&rft.aufirst=Johannes&rft.date=2005-01-01&rft.volume=11&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Cites: J Int Neuropsychol Soc. 1995 May;1(3):231-51[9375218]; 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Cites: Biol Psychiatry. 1995 Sep 1;38(5):343-4[7495932]; Cites: Am J Psychiatry. 1995 Jan;152(1):53-9[7802120]; Cites: Acta Neurol Scand. 1993 Feb;87(2):88-94[8442401]; Cites: Neurology. 1996 Jun;46(6):1697-702[8649573]; Cites: AIDS Care. 1996 Jun;8(3):261-9[8827119]; Cites: N Engl J Med. 1997 Sep 11;337(11):725-33[9287227] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Ultrasound measurement of mandibular arterial blood supply: techniques for defining ischemia in the pathogenesis of alveolar ridge atrophy and tooth loss in the elderly? AN - 85378522; pmid-15635554 AB - To adapt ultrasound methods used to measure blood flow in the extremities to quantify mandible blood flow in order to determine the role of ischemia in the pathogenesis of mandible atrophy and tooth loss in the elderly.Doppler and duplex ultrasound techniques as used in measurement of arterial pulse in the extremities were adapted for recording the intraoral pulse profile at 7 sites in 57 patients of varying ages.After omitting the large number (26 patients) with signals of indeterminate strength, the mental artery pulse was strong in 11 of 12 (92%) in those younger than 65 versus 9 of 19 (47% in those older than 65 years; P = .02). The equivalent figures for the sublingual artery were 15 of 15 strong for those younger than 65 and 11 of 17 (65%) for those older than 65 years ( P = .02). The varying depth of soft tissue overlying the inferior alveolar artery made its signal difficult to evaluate, but there was no statistically significant age-related difference in the inferior alveolar artery signals. In 4 elderly patients (2 with established carotid artery disease), Doppler and duplex scanning showed reversal of mental artery flow, indicating collateral flow to the mandible.Ultrasound Doppler techniques used for measuring peripheral arterial flow can be adapted to quantify mandible alveolar ridge perfusion. This provides means to evaluate the role of arterial obstruction in mandible alveolar ridge atrophy and tooth loss in the elderly. The mental artery is the best site for this purpose. Preliminary data suggest an age-related reduction in mental artery flow. JF - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons AU - Eiseman, Ben AU - Johnson, Lonnie R AU - Coll, Joseph R AD - University of Colorado Health Science Center, Denver, CO 80262, USA. Ben.Eiseman@Med.VA.gov Y1 - 2005/01// PY - 2005 DA - Jan 2005 SP - 28 EP - 35 VL - 63 IS - 1 SN - 0278-2391, 0278-2391 KW - National Library of Medicine KW - Age Factors KW - Aged KW - *Alveolar Bone Loss: etiology KW - *Alveolar Process: blood supply KW - *Arteries: ultrasonography KW - Arteriosclerosis: complications KW - Collateral Circulation KW - Humans KW - *Ischemia: complications KW - *Mandible: blood supply KW - Middle Aged KW - Mouth: blood supply KW - Pulse KW - *Tooth Loss: etiology KW - *Ultrasonography, Doppler: methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85378522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.atitle=Ultrasound+measurement+of+mandibular+arterial+blood+supply%3A+techniques+for+defining+ischemia+in+the+pathogenesis+of+alveolar+ridge+atrophy+and+tooth+loss+in+the+elderly%3F&rft.au=Eiseman%2C+Ben%3BJohnson%2C+Lonnie+R%3BColl%2C+Joseph+R&rft.aulast=Eiseman&rft.aufirst=Ben&rft.date=2005-01-01&rft.volume=63&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.issn=02782391&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Alcohol and hepatitis C. AN - 70142522; 16508293 AB - Alcohol use and hepatitis C are prominent risk factors for liver injury and this review offers the current understanding of each factor's effects on liver disease. A Medline database search was preformed for English articles with a focus on alcohol, hepatitis C and liver disease. Article citations were also considered for further applicable articles, and the strongest studies were included in our review. Up to 60% of patients with hepatitis C have a past history of alcohol use. In patients with hepatitis C, chronic alcohol consumption of more than 5 drinks/day increases the rate of liver fibrosis, risk for cirrhosis, hepatocellular carcinoma, and, possibly, death from liver disease. Numerous studies have further found that even moderate amounts of alcohol can be detrimental to hepatitis C patients. The prevalence of hepatitis C is higher in alcoholics with advanced liver disease than in alcoholics without liver disease. Also, recent alcohol use decreases the response rate to interferon treatment. Hepatitis C and alcohol use are often co-occurring risk factors for liver disease, and though their interaction is not clear, it is known that heavy drinking significantly promotes liver disease progression. Copyright 2005 S. Karger AG, Basel. JF - Digestive diseases (Basel, Switzerland) AU - Jamal, M Mazen AU - Saadi, Zainab AU - Morgan, Timothy R AD - Long Beach VA Medical Center and University of California, Irvine, Long Beach, CA 90822, USA. mazen.jamal@med.va.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 285 EP - 296 VL - 23 IS - 3-4 SN - 0257-2753, 0257-2753 KW - Biomarkers KW - 0 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Severity of Illness Index KW - Ethanol -- adverse effects KW - Survival Rate KW - Humans KW - Biomarkers -- analysis KW - Prognosis KW - Disease Progression KW - Ethanol -- metabolism KW - Liver Function Tests KW - Male KW - Female KW - Risk Assessment KW - Prevalence KW - Liver Cirrhosis, Alcoholic -- etiology KW - Liver Cirrhosis, Alcoholic -- pathology KW - Hepatitis C, Chronic -- etiology KW - Hepatitis C, Chronic -- epidemiology KW - Alcohol Drinking -- adverse effects KW - Liver Cirrhosis, Alcoholic -- epidemiology KW - Hepatitis C, Chronic -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70142522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+diseases+%28Basel%2C+Switzerland%29&rft.atitle=Alcohol+and+hepatitis+C.&rft.au=Jamal%2C+M+Mazen%3BSaadi%2C+Zainab%3BMorgan%2C+Timothy+R&rft.aulast=Jamal&rft.aufirst=M&rft.date=2005-01-01&rft.volume=23&rft.issue=3-4&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Digestive+diseases+%28Basel%2C+Switzerland%29&rft.issn=02572753&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-07 N1 - Date created - 2006-03-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Resolving disputes about toxicological risks during military conflict : the US Gulf War experience. AN - 69054884; 16390218 AB - In the last 15 years, the US and UK have fought two major wars in the Persian Gulf region. Controversy has arisen over the nature and causes of health problems among military veterans of these two wars. Toxic exposures have been hypothesised to cause the majority of the long-term health problems experienced by veterans of the 1991 Gulf War. The assessment of these toxic exposures and the resolution of controversy about their health effects provide a unique case study for understanding how toxicological disputes are settled in the US. Neither clinical examination of ill war veterans nor scientific research studies have been sufficient to answer contentious questions about toxic exposures. Numerous expert review panels have also been unable to resolve these controversies except for the US National Academy of Sciences Institute of Medicine (IOM). The IOM has conducted exhaustive and independent investigations based on peer-reviewed scientific literature related to potential health risks during the two Gulf Wars. In four recent studies, IOM committees identified a wide range of previously documented illnesses associated with common occupational and environmental exposures after considering thousands of relevant publications; however, they did not identify a new medical syndrome or a specific toxic exposure that caused widespread health problems among Gulf War veterans. These IOM studies have, therefore, added little to our basic knowledge of environmental hazards because most of the health effects were well known. Nevertheless, this expert review process, which is on-going, has been generally acceptable to a wide range of competing interests because the findings of the IOM have been perceived as scientifically credible and independent, and because none of the postulated toxicological risks have been completely ruled-out as possible causes of ill health among veterans. JF - Toxicological reviews AU - Hyams, Kenneth C AU - Brown, Mark AU - White, David S AD - United States Department of Veterans Affairs, Office of Public Health and Environmental Hazards, Washington, DC 20420, USA. Y1 - 2005 PY - 2005 DA - 2005 SP - 167 EP - 180 VL - 24 IS - 3 SN - 1176-2551, 1176-2551 KW - Index Medicus KW - Veterans KW - United States KW - Health Status KW - United Kingdom KW - Risk Assessment KW - Expert Testimony KW - Gulf War KW - Military Personnel KW - Persian Gulf Syndrome -- diagnosis KW - Persian Gulf Syndrome -- etiology KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69054884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+reviews&rft.atitle=Resolving+disputes+about+toxicological+risks+during+military+conflict+%3A+the+US+Gulf+War+experience.&rft.au=Hyams%2C+Kenneth+C%3BBrown%2C+Mark%3BWhite%2C+David+S&rft.aulast=Hyams&rft.aufirst=Kenneth&rft.date=2005-01-01&rft.volume=24&rft.issue=3&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Toxicological+reviews&rft.issn=11762551&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-30 N1 - Date created - 2006-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of concomitant use of benzodiazepines and other drugs on the risk of injury in a veterans population. AN - 68870070; 16329716 AB - Benzodiazepines comprise a class of drugs that when used as monotherapy are generally acknowledged to pose a risk for injury by increasing the likelihood of falls, fall-related injuries, adverse drug events and car accidents. Benzodiazepines may also be used concomitantly with other high risk medications that may further exacerbate the risk of injury. The aim of this study is to examine the occurrence of the concomitant use of benzodiazepines and other drugs and then quantify the indirect effect of these drug combinations on the likelihood of an injury-related health care episode. A multivariate model was specified that included outpatient prescription data and inpatient/outpatient medical utilisation records for 13,745 patients at a Veterans Administration hospital system over a 3-year period (1999-2001). We analysed 1,33,872 outpatient benzodiazepine prescriptions and >1.5 million non-benzodiazepine prescriptions for the study population. Micromedex software was used to identify combinations of benzodiazepines and other drugs that are likely to result in 'major' interactions. We then further restricted our focus to the use of these drug combinations within a 30-day period prior to an injury-related medical event. The adjusted odds ratio on a variable characterising concomitant use of a benzodiazepine and another drug within this period was used to quantify the relative risk of injury. The principal outcome was the estimated risk of an injury-related health care episode within a 30-day period when taking both a benzodiazepine and another drug with a 'major' severity rating as defined by Micromedex. The risk of injury was adjusted for comorbidities, hospital discharges, marital status, age, mean arterial pressure and body mass index, as well as the dose of benzodiazepine (converted to diazepam equivalents) and duration of benzodiazepine treatment. Of the 1,110 unique individuals who experienced an injury, 790 (71.2%) patients had used a benzodiazepine in combination with another drug. Furthermore, only 4.3% (320/7522) of the patients taking benzodiazepines who did not have concomitant drug use experienced an injury. The occurrence of this concomitant use increased the odds of an injury >2-fold in the model. Dose and duration of benzodiazepine use, as well as certain comorbidities, were also associated with an increased risk for injury, whereas being married reduced the risk. This is the first large-scale study to quantify the impact of concomitant use of benzodiazepines and other drugs on the risk of injury in a population of Veterans Administration patients. It demonstrates the utility of expanding the focus of inappropriate medication usage to include analyses that link potentially inappropriate drug use with health care utilisation for injuries. JF - Drug safety AU - French, Dustin D AU - Chirikos, Thomas N AU - Spehar, Andrea AU - Campbell, Robert AU - Means, Heidi AU - Bulat, Tatjana AD - VISN-8 Measurement and Evaluation Team, James A. Haley Hospital, Tampa, Florida 33612, USA. Dustin.French@med.va.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 1141 EP - 1150 VL - 28 IS - 12 SN - 0114-5916, 0114-5916 KW - Anti-Anxiety Agents KW - 0 KW - Benzodiazepines KW - 12794-10-4 KW - Index Medicus KW - Medical Records KW - Drug Interactions KW - Logistic Models KW - Risk Factors KW - Humans KW - Retrospective Studies KW - Middle Aged KW - Accident Prevention KW - Drug Prescriptions KW - Hospitals, Veterans KW - Veterans KW - Benzodiazepines -- adverse effects KW - Wounds and Injuries -- etiology KW - Benzodiazepines -- administration & dosage KW - Anti-Anxiety Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68870070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=Effect+of+concomitant+use+of+benzodiazepines+and+other+drugs+on+the+risk+of+injury+in+a+veterans+population.&rft.au=French%2C+Dustin+D%3BChirikos%2C+Thomas+N%3BSpehar%2C+Andrea%3BCampbell%2C+Robert%3BMeans%2C+Heidi%3BBulat%2C+Tatjana&rft.aulast=French&rft.aufirst=Dustin&rft.date=2005-01-01&rft.volume=28&rft.issue=12&rft.spage=1141&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=01145916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-14 N1 - Date created - 2005-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevention of nephropathy in patients with type 2 diabetes mellitus. AN - 68826062; 16307358 AB - The rising incidence of type 2 diabetes mellitus and of its complications will make it the most important health care challenge in the first quarter of the 21st Century. Diabetic nephropathy left unchecked will overwhelm the renal resources. Simple methods (proper diet and exercise, prevention of obesity) are successful in preventing type 2 diabetes in the great majority of the persons at risk. In patients with established type 2 diabetes, nephropathy can be prevented or greatly delayed by strict metabolic control, strict control of blood pressure using angiotensin-converting enzyme inhibitors and angiotensin receptor blockers as the first line of drugs, tight control of serum lipids using statins as indicated, low protein diet, avoidance of smoking and other nephrotoxic influences, prevention of abnormalities in calcium/phosphorus metabolism, and prevention of renal anemia by the early use of erythropoietin. Current research offers the promise of definitive prevention of both type 2 diabetes and diabetic nephropathy. JF - International urology and nephrology AU - Tzamaloukas, Antonios H AU - Murata, Glen H AD - Section of Nephrology, Renal Section (111C), New Mexico Veterans Affairs Health Care System, Albuquerque, New Mexico 87108, USA. Antonios.tzamaloukas@med.va.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 655 EP - 663 VL - 37 IS - 3 SN - 0301-1623, 0301-1623 KW - Erythropoietin KW - 11096-26-7 KW - Index Medicus KW - Mitochondria -- physiology KW - Animals KW - Glomerular Filtration Rate KW - Hypertension -- epidemiology KW - Humans KW - Erythropoietin -- therapeutic use KW - Disease Progression KW - Anemia -- drug therapy KW - Diabetes Mellitus, Type 2 -- genetics KW - Albuminuria -- etiology KW - Hypertension -- drug therapy KW - Diabetic Nephropathies -- prevention & control KW - Diabetic Nephropathies -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68826062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+urology+and+nephrology&rft.atitle=Prevention+of+nephropathy+in+patients+with+type+2+diabetes+mellitus.&rft.au=Tzamaloukas%2C+Antonios+H%3BMurata%2C+Glen+H&rft.aulast=Tzamaloukas&rft.aufirst=Antonios&rft.date=2005-01-01&rft.volume=37&rft.issue=3&rft.spage=655&rft.isbn=&rft.btitle=&rft.title=International+urology+and+nephrology&rft.issn=03011623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-28 N1 - Date created - 2005-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The impact of enhanced incentives on vocational rehabilitation outcomes for dually diagnosed veterans. AN - 68766171; 16270845 AB - This study evaluated the efficacy of adding contingency management techniques to vocational rehabilitation (VR) to improve treatment outcome as measured by entry into competitive employment. Nineteen dually diagnosed veterans who entered VR in the Veterans' Administration's compensated work therapy (CWT) program were randomly assigned to CWT (n = 8) or to CWT with enhanced incentives (n = 11). Over the first 16 weeks of rehabilitation, those in the incentives condition could earn up to dollar 1,006 in cash for meeting two sets of clinical goals: (a) remaining abstinent from drugs and alcohol and (b) taking steps to obtain and maintain a competitive job. Results indicate that relative to participants in the CWT-only group, those in the incentives condition engaged in more job-search activities, were more likely to remain abstinent from drugs and alcohol, were more likely to obtain competitive employment, and earned an average of 68% more in wages. These results suggest that rehabilitation outcomes may be enhanced by restructuring traditional work-for-pay contingencies to include direct financial rewards for meeting clinical goals. JF - Journal of applied behavior analysis AU - Drebing, Charles E AU - Van Ormer, E Alice AU - Krebs, Christopher AU - Rosenheck, Robert AU - Rounsaville, Bruce AU - Herz, Lawrence AU - Penk, Walter AD - Bedford VA Medical Center, Massachusetts, USA. Charles.Drebing@med.va.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 359 EP - 372 VL - 38 IS - 3 SN - 0021-8855, 0021-8855 KW - Index Medicus KW - Reward KW - Mental Disorders -- epidemiology KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Middle Aged KW - Recurrence KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - Motivation KW - Reinforcement (Psychology) KW - Veterans -- psychology KW - Rehabilitation, Vocational KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68766171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+behavior+analysis&rft.atitle=The+impact+of+enhanced+incentives+on+vocational+rehabilitation+outcomes+for+dually+diagnosed+veterans.&rft.au=Drebing%2C+Charles+E%3BVan+Ormer%2C+E+Alice%3BKrebs%2C+Christopher%3BRosenheck%2C+Robert%3BRounsaville%2C+Bruce%3BHerz%2C+Lawrence%3BPenk%2C+Walter&rft.aulast=Drebing&rft.aufirst=Charles&rft.date=2005-01-01&rft.volume=38&rft.issue=3&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+behavior+analysis&rft.issn=00218855&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-31 N1 - Date created - 2005-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Alcohol Depend. 1996 Jul;41(3):197-207 [8842632] Arch Gen Psychiatry. 1994 Jul;51(7):568-76 [8031230] Addict Behav. 1996 Nov-Dec;21(6):803-16 [8904945] Drug Alcohol Depend. 1996 Dec 2;43(1-2):39-47 [8957141] J Consult Clin Psychol. 1997 Jun;65(3):421-8 [9170765] J Consult Clin Psychol. 1997 Oct;65(5):803-10 [9337499] Drug Alcohol Depend. 2000 Feb 1;58(1-2):9-25 [10669051] J Consult Clin Psychol. 2000 Apr;68(2):250-7 [10780125] J Consult Clin Psychol. 2000 Dec;68(6):1051-61 [11142539] J Subst Abuse Treat. 2001 Jan;20(1):33-44 [11239726] Exp Clin Psychopharmacol. 2001 Feb;9(1):14-23 [11519628] J Occup Health Psychol. 2002 Jan;7(1):68-83 [11827235] Exp Clin Psychopharmacol. 2002 Aug;10(3):228-40 [12233983] Arch Gen Psychiatry. 2002 Oct;59(10):938-44 [12365881] Drug Alcohol Depend. 1986 Dec;18(4):341-8 [3816530] J Psychoactive Drugs. 1990 Apr-Jun;22(2):197-209 [2197394] Am J Psychiatry. 1991 Sep;148(9):1218-24 [1883001] J Consult Clin Psychol. 1996 Apr;64(2):391-9 [8871423] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of caffeine on heart rate and QT variability during sleep. AN - 68752739; 16184581 AB - Administration of caffeine in the evening produces poor sleep. Patients with insomnia have characteristic electrocardiogram (ECG) changes, including increased heart rate (HR), increased sympathetic activity, and decreased parasympathetic activity. Fifteen young adult normal subjects slept in the laboratory for several nights prior to randomization into a caffeine protocol where subjects received caffeine 400 mg 30 min prior to one night of sleep and placebo randomly prior to another night. ECG was sampled at a rate of 500 Hz and recorded onto a PC. Data samples of 256-s periods of the ECG trace were taken from wake (before sleep), stage II, and REM for placebo and caffeine conditions. A peak detection algorithm was used to identify the R-R intervals (in milliseconds) from the ECG. A common QT variability algorithm was used to find the QT interval for each beat using the time-stretch model. The powers for HR and QT series were integrated in the bands of LF (low frequency: 0.04-0.15 Hz) and HF (high frequency: 0.15-0.5 Hz) bands. There was a significant caffeine by sleep stage interaction for LF/HF ratios (F = 4.0; df = 2, 18; P = .04). LF/HF ratios were significantly higher during REM following caffeine administration. There was also a significant caffeine by sleep stage interaction for QTvi (QT variability normalized for mean QT interval divided by HR variability normalized for mean HR; F = 5.6; df = 2, 12; P = .02). QTvi was also significantly higher during REM following caffeine administration. The higher LF/HF ratios and QTvi during REM are most likely due to the sympathetic effects of caffeine. These findings suggest that excessive caffeine intake may result in adverse cardiovascular events in vulnerable subjects. Copyright 2005 Wiley-Liss, Inc. JF - Depression and anxiety AU - Bonnet, Michael AU - Tancer, Manuel AU - Uhde, Thomas AU - Yeragani, Vikram K AD - Wright State University School of Medicine and the Veterans Administration Hospital, Dayton, Ohio, USA. Y1 - 2005 PY - 2005 DA - 2005 SP - 150 EP - 155 VL - 22 IS - 3 SN - 1091-4269, 1091-4269 KW - Caffeine KW - 3G6A5W338E KW - Index Medicus KW - Sleep, REM -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Electrocardiography KW - Algorithms KW - Wakefulness -- drug effects KW - Periodicity KW - Heart Rate -- drug effects KW - Long QT Syndrome -- chemically induced KW - Caffeine -- administration & dosage KW - Sleep -- drug effects KW - Long QT Syndrome -- diagnosis KW - Caffeine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68752739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+anxiety&rft.atitle=Effects+of+caffeine+on+heart+rate+and+QT+variability+during+sleep.&rft.au=Bonnet%2C+Michael%3BTancer%2C+Manuel%3BUhde%2C+Thomas%3BYeragani%2C+Vikram+K&rft.aulast=Bonnet&rft.aufirst=Michael&rft.date=2005-01-01&rft.volume=22&rft.issue=3&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Depression+and+anxiety&rft.issn=10914269&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-03 N1 - Date created - 2005-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aprepitant (EMEND): the role of substance P in nausea and vomiting. AN - 68680136; 16219609 AB - Aprepitant (EMEND) is the first commercially available drug from a new class of agents, the Substance P/neurokinin NK-1 receptor antagonists. Aprepitant is indicated for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) associated with highly emetogenic chemotherapy in adults. Its ability to antagonize the effects of Substance P has lead to greater understanding of the pathophysiology of nausea and vomiting. Its broad range of activity against a wide variety of central and peripheral emetogenic stimuli make it potentially useful in non-chemotherapy related nausea and vomiting. JF - Journal of pain & palliative care pharmacotherapy AU - Prommer, Eric AD - UCLA School of Medicine, Division of Hematology/Oncology, Los Angeles, CA 90073, USA. eric.prommer@med.va.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 31 EP - 39 VL - 19 IS - 3 SN - 1536-0288, 1536-0288 KW - Antiemetics KW - 0 KW - Antineoplastic Agents KW - Morpholines KW - Neurokinin-1 Receptor Antagonists KW - Receptors, Neurokinin-1 KW - aprepitant KW - 1NF15YR6UY KW - Substance P KW - 33507-63-0 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Animals KW - Liver -- enzymology KW - Drug Interactions KW - Liver -- drug effects KW - Humans KW - Clinical Trials as Topic KW - Receptors, Neurokinin-1 -- metabolism KW - Cisplatin -- adverse effects KW - Cytochrome P-450 Enzyme System -- drug effects KW - Antineoplastic Agents -- adverse effects KW - Antiemetics -- therapeutic use KW - Morpholines -- pharmacokinetics KW - Vomiting -- prevention & control KW - Antiemetics -- pharmacokinetics KW - Nausea -- prevention & control KW - Vomiting -- chemically induced KW - Morpholines -- pharmacology KW - Substance P -- antagonists & inhibitors KW - Substance P -- metabolism KW - Antiemetics -- pharmacology KW - Nausea -- chemically induced KW - Morpholines -- therapeutic use KW - Vomiting -- metabolism KW - Nausea -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68680136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pain+%26+palliative+care+pharmacotherapy&rft.atitle=Aprepitant+%28EMEND%29%3A+the+role+of+substance+P+in+nausea+and+vomiting.&rft.au=Prommer%2C+Eric&rft.aulast=Prommer&rft.aufirst=Eric&rft.date=2005-01-01&rft.volume=19&rft.issue=3&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Journal+of+pain+%26+palliative+care+pharmacotherapy&rft.issn=15360288&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-26 N1 - Date created - 2005-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A national survey of dental hygienists' infection control attitudes and practices. AN - 68645538; 16197765 AB - The objectives of this study were to: 1) investigate the infection control practices of practicing dental hygienists, 2) document the attitudes and practices of dental hygienists toward patients with infectious diseases, and 3) determine if professional affiliation affected the attitudes and/or practices of the respondents. A 49-item survey consisting of eight demographic, nine attitudinal, and 32 practice questions was used for this study. A stratified sampling method was used, in which the United States was divided into four regions. Three states were selected from each region according to geographic location and population. Five percent of registered dental hygienists within each selected state were randomly selected for inclusion in the study. All analyses were conducted using the Statistical Package for Social Scientists (SPSS v.10, Chicago, IL). Of the 2,009 surveys mailed, 104 were undeliverable. A total of 856 completed surveys were returned from practicing dental hygienists for a response rate of 44.9%. Overall, this study found an increased use of barriers and personal protective equipment in comparison to previous studies. A majority of respondents (53.9%) felt that treating patients with HIV or AIDS increased their personal risk for contracting the disease. The majority of respondents also reported always using extra precautions with HIV/AIDS patients (63.5%) and hepatitis patients (60.1%). In addition, most respondents reported they would not use an ultrasonic scaler when treating HIV/AIDS (65.8%) or hepatitis (58.9%) patients, indicating an alteration in clinical practice habits. The majority of dental hygienists surveyed reported altering infection control practices and treatment techniques when treating HIV/AIDS or hepatitis patients. While there has been an improvement in compliance with recommended infection control guidelines, practitioners still have misconceptions, and possibly fear, regarding infectious diseases and disease transmission. JF - Journal of dental hygiene : JDH AU - King, Tracy B AU - Muzzin, Kathleen B AD - Homeless Veterans Dental Program, Affairs North Texas Health Care System, Dallas, Texas, USA. tracy.king@med.va.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 8 VL - 79 IS - 2 KW - Dentistry KW - United States KW - Hepatitis, Viral, Human -- psychology KW - Protective Clothing -- utilization KW - Humans KW - Air Pollution, Indoor -- prevention & control KW - Hepatitis, Viral, Human -- prevention & control KW - Equipment Contamination -- prevention & control KW - Sampling Studies KW - Societies, Dental KW - Surveys and Questionnaires KW - Hepatitis, Viral, Human -- transmission KW - Female KW - Male KW - Attitude of Health Personnel KW - Infection Control, Dental -- methods KW - HIV Infections -- transmission KW - Dental Hygienists -- psychology KW - HIV Infections -- prevention & control KW - Infectious Disease Transmission, Patient-to-Professional -- prevention & control KW - HIV Infections -- psychology KW - Dental Hygienists -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68645538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+dental+hygiene+%3A+JDH&rft.atitle=A+national+survey+of+dental+hygienists%27+infection+control+attitudes+and+practices.&rft.au=King%2C+Tracy+B%3BMuzzin%2C+Kathleen+B&rft.aulast=King&rft.aufirst=Tracy&rft.date=2005-01-01&rft.volume=79&rft.issue=2&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Journal+of+dental+hygiene+%3A+JDH&rft.issn=1553-0205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-15 N1 - Date created - 2005-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cocaine addicts prone to cocaine-induced psychosis have lower body mass index than cocaine addicts resistant to cocaine-induced psychosis--Implications for the cocaine model of psychosis proneness. AN - 68549632; 16134406 AB - The specific pathogenesis of increased vulnerability to cocaine-induced paranoia/psychosis is unknown. Weight loss has been long observed in patients abusing stimulants (including cocaine and the amphetamines). In the current study, we compared Body Mass Index (calculated as weight in kilograms divided by the square of height in meters) in Cocaine-Induced Psychosis cases, referred to as "Cocaine-Induced Psychosis-prone" (n=40) and non-Cocaine-Induced Psychosis cases, referred to as "Cocaine-Induced Psychosis-resistant" (n=29) consecutively admitted to a research substance abuse unit to determine whether Body Mass Index is associated with Cocaine-Induced Psychosis. Height and weight were measured and Body Mass Index calculated by a licensed nutritionist using a standardized protocol. Cocaine-induced psychosis and cocaine use patterns were assessed using the Cocaine Experience Questionnaire. Body Mass Index in the Cocaine-Induced Psychosis-prone patients was significantly lower than in the Cocaine-Induced Psychosis-resistant patients (i.e., 23.1 kg/m2 +/-2.5 vs. 25.4 kg/m2 +/-3.5 (P=.003), respectively). Percentage of Ideal Body Weight also differed significantly between the two groups. The data suggest that lower Body Mass Index may be associated with increasing proneness to developing psychotic symptoms in the context of crack cocaine use or that higher Body Mass Index might be associated with some protection against Cocaine-Induced Psychosis in the context of similar use patterns. In the Discussion the authors speculate as to why Cocaine-Induced Psychosis is more commonly observed in the patient population with lower Body Mass Index and lower percentage of Ideal Body Weight. They evoke possible involvement of cocaine's influence on the anorexigenic cytokine Tumor Necrosis Factor, Cocaine-and-Amphetamine-Regulated Transcript, or suppression of the appetite stimulating Neuropeptide Y, or cocaine-induced deficits in nicotinic cholinergic neural-transmission, all of which have not only been linked to weight and appetite, but also to idiopathic psychosis. It could be speculated that one or more of these systems might be differentially affected by cocaine addiction in the psychosis prone Cocaine-Induced Psychosis group vs. the psychosis resistant non-Cocaine-Induced Psychosis group. Further exploration of these possible associations seem warranted. Such findings would have implications for the cocaine model of psychosis proneness and perhaps for the stimulant model of psychoses in general. JF - The Israel journal of psychiatry and related sciences AU - Rosse, Richard AU - Deutsch, Stephen AU - Chilton, Melissa AD - Department of Veterans Affairs Medical Center, Washington, DC, USA. RichardRosse@med.va.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 45 EP - 50 VL - 42 IS - 1 SN - 0333-7308, 0333-7308 KW - Index Medicus KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Body Mass Index KW - Male KW - Female KW - Psychotic Disorders -- etiology KW - Psychotic Disorders -- diagnosis KW - Cocaine-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68549632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Israel+journal+of+psychiatry+and+related+sciences&rft.atitle=Cocaine+addicts+prone+to+cocaine-induced+psychosis+have+lower+body+mass+index+than+cocaine+addicts+resistant+to+cocaine-induced+psychosis--Implications+for+the+cocaine+model+of+psychosis+proneness.&rft.au=Rosse%2C+Richard%3BDeutsch%2C+Stephen%3BChilton%2C+Melissa&rft.aulast=Rosse&rft.aufirst=Richard&rft.date=2005-01-01&rft.volume=42&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=The+Israel+journal+of+psychiatry+and+related+sciences&rft.issn=03337308&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-20 N1 - Date created - 2005-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis. AN - 68454000; 16023152 AB - Group I metabotropic glutamate receptor (mGluR) agonist DHPG reduced nerve cell death caused by their exposure to NMDA ("neuroprotective effect") and attenuated NMDA receptor-mediated currents [Blaabjerg, M., Baskys, A., Zimmer, J., Vawter, M. P., 2003b. Changes in hippocampal gene expression after neuroprotective activation of group I metabotropic glutamate receptors. Brain Research, Molecular Brain Research 117, 196-205.]. In the present study, we used organotypic hippocampal culture preparation to examine specific phospholipase C (PLC) inhibitor U73122 effects on DHPG-induced neuroprotection, changes in excitatory synaptic transmission associated with the neuroprotective DHPG treatment and a role of group I mGluR ligands in neurogenesis. Results show that short (10 min) DHPG treatment did not result in neuroprotection but significantly depressed field synaptic potentials (fEPSP) in the Schaffer collateral-CA1 pathway. The fEPSP depression was not affected by the PLC inhibitor U73122. In contrast, prolonged (2-h) treatment of cultures with DHPG induced a significant protective effect that was blocked by a PLC inhibitor U73122 but not by its inactive analog U73343. Voltage-clamp measurements of spontaneous miniature excitatory post-synaptic currents (EPSCs) recorded in CA1 neurons from cultures treated with DHPG (10 microM, 2 h) showed a significant reduction of the EPSC amplitude in DHPG-treated but not control (untreated) cultures. This reduction was completely abolished by U73122, suggesting a PLC involvement. Since activation of PLC is thought to be associated with cell proliferation, we investigated whether group I mGluR agonist DHPG or subtype antagonists LY367385 and MPEP have an effect on dentate granule cells expressing immature neuronal marker TOAD-64. DHPG (100 microM, 72 h) slightly but not significantly increased the number of TOAD-64 positive cells. The mGluR1 antagonists LY367385 (10 microM, 72 h) markedly decreased the number of TOAD-64 positive cells and mGluR5 antagonist MPEP (1 microM, 72 h) had no effect. These data suggest that (1) prolonged activation of group I mGluRs reduces nerve cell susceptibility to excitotoxic injury in a PLC-dependent manner; (2) this reduction is associated with a PLC-dependent depression of excitatory synaptic transmission; and (3) mGluR1 activation may facilitate neurogenesis. JF - Neuropharmacology AU - Baskys, Andrius AU - Bayazitov, Ildar AU - Fang, Liwei AU - Blaabjerg, Morten AU - Poulsen, Frantz Rom AU - Zimmer, Jens AD - Department of Mental Health, VA Health Care System, Mental Illness Research and Education Clinical Center, Long Beach, University of California at Irvine, 06/116A, 5901 East Seventh Street Long Beach, CA, 90822 Irvine, CA, USA. andrius.baskys@med.va.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 146 EP - 156 VL - 49 Suppl 1 SN - 0028-3908, 0028-3908 KW - Benzoates KW - 0 KW - Crmp4 protein, rat KW - Estrenes KW - Excitatory Amino Acid Agonists KW - Excitatory Amino Acid Antagonists KW - Nerve Tissue Proteins KW - Phosphodiesterase Inhibitors KW - Pyrrolidinones KW - Receptors, Metabotropic Glutamate KW - metabotropic glutamate receptor type 1 KW - 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione KW - 112648-68-7 KW - U 73343 KW - 142878-12-4 KW - alpha-methyl-4-carboxyphenylglycine KW - 146669-29-6 KW - Propidium KW - 36015-30-2 KW - Methoxyhydroxyphenylglycol KW - 534-82-7 KW - N-Methylaspartate KW - 6384-92-5 KW - dihydroxyphenylethylene glycol KW - CF5G2G268A KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Animals KW - Electric Stimulation -- methods KW - Drug Interactions KW - Analysis of Variance KW - Methoxyhydroxyphenylglycol -- analogs & derivatives KW - Glycine -- analogs & derivatives KW - Models, Biological KW - Excitatory Amino Acid Antagonists -- pharmacology KW - Rats KW - Excitatory Postsynaptic Potentials -- drug effects KW - Glycine -- pharmacology KW - In Vitro Techniques KW - Gene Expression Regulation -- drug effects KW - Estrenes -- pharmacology KW - Pyrrolidinones -- pharmacology KW - Excitatory Postsynaptic Potentials -- physiology KW - Patch-Clamp Techniques -- methods KW - Phosphodiesterase Inhibitors -- pharmacology KW - Immunohistochemistry -- methods KW - Dose-Response Relationship, Radiation KW - Cell Death -- drug effects KW - Benzoates -- pharmacology KW - Animals, Newborn KW - Cell Count -- methods KW - Rats, Wistar KW - Methoxyhydroxyphenylglycol -- pharmacology KW - Nerve Tissue Proteins -- metabolism KW - Hippocampus -- physiology KW - N-Methylaspartate -- toxicity KW - Hippocampus -- injuries KW - Receptors, Metabotropic Glutamate -- physiology KW - Excitatory Amino Acid Agonists -- toxicity KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68454000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Group+I+metabotropic+glutamate+receptors+reduce+excitotoxic+injury+and+may+facilitate+neurogenesis.&rft.au=Baskys%2C+Andrius%3BBayazitov%2C+Ildar%3BFang%2C+Liwei%3BBlaabjerg%2C+Morten%3BPoulsen%2C+Frantz+Rom%3BZimmer%2C+Jens&rft.aulast=Baskys&rft.aufirst=Andrius&rft.date=2005-01-01&rft.volume=49+Suppl+1&rft.issue=&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-07 N1 - Date created - 2005-08-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of N-methyl-d-aspartate receptor blockade on neuronal plasticity and gastrointestinal transit delay induced by ischemia/reperfusion in rats. AN - 68022543; 15939544 AB - Intestinal ischemia impairs gastrointestinal motility. The aims of this study were to investigate the effect of intestinal ischemia on gastrointestinal transit and on the expression of enteric transmitters in the rat, and whether the glutamate N-methyl-d-aspartate receptors influence these effects. Ischemia (1 h), induced by occluding the superior mesenteric artery, was followed by 0 or 24 h of reperfusion. Normal and sham-operated rats served as controls. Serosal blood flow was measured with laser Doppler flow meter. Gastrointestinal transit was measured as time of appearance of a marker in fecal pellets. Immunohistochemistry was used to evaluate the number of neurons immunoreactive for neuronal nitric oxide synthase (NOS) or vasoactive intestinal polypeptide and the density of substance P immunoreactive fibers in the myenteric plexus. The N-methyl-d-aspartate receptors antagonist, (+)-5-methyl-10,11-dihydro-5HT-[a,b] cyclohepten-5,10-imine (MK-801) (1 mg/kg i.v.) or the NOS inhibitor, N-nitro-l-arginine (10 mg/kg i.v.) was administered prior to ischemia. Serosal blood flow was decreased by 70% during ischemia, but it was not altered in sham-operated rats. Gastrointestinal transit was significantly prolonged in ischemic/reperfused rats compared with controls. There was a significant increase in the number of vasoactive intestinal polypeptide and neuronal nitric oxide synthase immunoreactive neurons, and a marked decrease of substance P immunoreactive fibers in ischemia followed by 24 h of reperfusion animals compared with controls. These alterations were not observed in ischemia without reperfusion. A significant delay of gastrointestinal transit and increase of vasoactive intestinal polypeptide neurons were also observed in sham-operated rats. The changes in transmitter expression and gastrointestinal transit in ischemic/reperfused rats were prevented by pre-treatment with the NOS inhibitor, N-nitro-l-arginine or the N-methyl-d-aspartate receptors antagonist, MK-801. This study suggests an involvement of the glutamatergic system and its interaction with nitric oxide in intestinal ischemia/reperfusion. Ischemia/reperfusion might induce local release of glutamate that activates N-methyl-d-aspartate receptors leading to increased production of nitric oxide and adaptive changes in enteric transmitters that might contribute to gastrointestinal dysmotility. JF - Neuroscience AU - Calcina, F AU - Barocelli, E AU - Bertoni, S AU - Furukawa, O AU - Kaunitz, J AU - Impicciatore, M AU - Sternini, C AD - CURE Digestive Diseases Research Center, Division of Digestive Diseases, Building 115, Room 224, Veterans Administration Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA. Y1 - 2005 PY - 2005 DA - 2005 SP - 39 EP - 49 VL - 134 IS - 1 SN - 0306-4522, 0306-4522 KW - Enzyme Inhibitors KW - 0 KW - Excitatory Amino Acid Antagonists KW - Receptors, N-Methyl-D-Aspartate KW - Vasoactive Intestinal Peptide KW - 37221-79-7 KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - Arginine KW - 94ZLA3W45F KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Drug Interactions KW - NG-Nitroarginine Methyl Ester -- pharmacology KW - Vasoactive Intestinal Peptide -- metabolism KW - Gastrointestinal Motility -- physiology KW - Regional Blood Flow -- drug effects KW - Immunohistochemistry -- methods KW - Neural Inhibition -- drug effects KW - Neural Inhibition -- physiology KW - Arginine -- pharmacology KW - Rats KW - Rats, Wistar KW - Laser-Doppler Flowmetry -- methods KW - Enzyme Inhibitors -- pharmacology KW - Gastrointestinal Motility -- drug effects KW - Time Factors KW - Regional Blood Flow -- physiology KW - Male KW - Reperfusion Injury -- metabolism KW - Receptors, N-Methyl-D-Aspartate -- physiology KW - Gastrointestinal Transit -- drug effects KW - Receptors, N-Methyl-D-Aspartate -- drug effects KW - Reperfusion Injury -- physiopathology KW - Ischemia -- physiopathology KW - Neuronal Plasticity -- drug effects KW - Gastrointestinal Transit -- physiology KW - Ischemia -- metabolism KW - Excitatory Amino Acid Antagonists -- pharmacology KW - Dizocilpine Maleate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68022543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Effect+of+N-methyl-d-aspartate+receptor+blockade+on+neuronal+plasticity+and+gastrointestinal+transit+delay+induced+by+ischemia%2Freperfusion+in+rats.&rft.au=Calcina%2C+F%3BBarocelli%2C+E%3BBertoni%2C+S%3BFurukawa%2C+O%3BKaunitz%2C+J%3BImpicciatore%2C+M%3BSternini%2C+C&rft.aulast=Calcina&rft.aufirst=F&rft.date=2005-01-01&rft.volume=134&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-02 N1 - Date created - 2005-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - GABA synapses and the rapid loss of inhibition to dentate gyrus granule cells after brief perforant-path stimulation. AN - 67985607; 15987269 AB - To study the pharmacologic and synaptic basis for the early loss of paired-pulse inhibition that occurs in the perforant-path stimulation model of status epilepticus. Hippocampal slices were prepared from male Wistar rats. Test paired pulses (20- to 50-ms interstimulus interval) of the perforant path were used before and after an abbreviated period of perforant-path stimulation (1-5 min; 2-Hz continuous with 20 Hz of 10 s/min pulses) while either recording field potentials from the dentate gyrus granule cell layer or directly measuring whole-cell patch-clamp currents from granule cells. Paired-pulse field recordings also were obtained during perfusion of the gamma-aminobutyric acid (GABA)(A) antagonist bicuculline. Prolonged loss of paired-pulse inhibition occurs after brief (< 5 min) perforant-path stimulation in vitro (similar to results in vivo) with the paired-pulse population spike amplitude ratio (P2/P1) increasing from a baseline of 0.53 +/- 0.29 to 1.17 +/- 0.09 after perforant-path stimulation (p < 0.05). After perfusion with the GABA(A) antagonist, bicuculline, the P2/P1 ratio also increased from a baseline of 0.52 +/- 0.16 to 1.15 +/- 0.26 (p < 0.05). After 1-2 min of perforant-path stimulation, a 22 +/- 6% (p < 0.05) decrease occurred in the P2/P1 amplitude ratio of paired-pulse evoked inhibitory postsynaptic currents. Similar to in vivo, loss of paired-pulse inhibition occurs with brief perforant-path stimulation in vitro. GABA(A) antagonism causes a similar loss of paired-pulse inhibition, and the effects of perforant-path stimulation on postsynaptic inhibitory currents also are consistent with the involvement of GABA(A) synaptic receptors. The findings suggest that loss of inhibition at GABA synapses may be an important early event in the initiation of status epilepticus. JF - Epilepsia AU - Naylor, David E AU - Wasterlain, Claude G AD - Department of Neurology, Veterans Administration Greater Los Angeles Healthcare Center and University of California at Los Angeles, Los Angeles, California 90073, USA. dnaylor@ucla.edu Y1 - 2005 PY - 2005 DA - 2005 SP - 142 EP - 147 VL - 46 Suppl 5 SN - 0013-9580, 0013-9580 KW - GABA Antagonists KW - 0 KW - Receptors, GABA-A KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Bicuculline KW - Y37615DVKC KW - Index Medicus KW - Bicuculline -- pharmacology KW - Animals KW - Receptors, GABA-A -- physiology KW - Neurons -- drug effects KW - Disease Models, Animal KW - Electric Stimulation KW - GABA Antagonists -- pharmacology KW - Rats KW - Patch-Clamp Techniques KW - In Vitro Techniques KW - Neurons -- physiology KW - Rats, Wistar KW - Receptors, GABA-A -- drug effects KW - Male KW - Status Epilepticus -- chemically induced KW - Synaptic Transmission -- drug effects KW - Status Epilepticus -- physiopathology KW - gamma-Aminobutyric Acid -- physiology KW - Perforant Pathway -- physiology KW - Neural Inhibition -- drug effects KW - Synaptic Transmission -- physiology KW - Dentate Gyrus -- physiology KW - Dentate Gyrus -- cytology KW - Neural Inhibition -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67985607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsia&rft.atitle=GABA+synapses+and+the+rapid+loss+of+inhibition+to+dentate+gyrus+granule+cells+after+brief+perforant-path+stimulation.&rft.au=Naylor%2C+David+E%3BWasterlain%2C+Claude+G&rft.aulast=Naylor&rft.aufirst=David&rft.date=2005-01-01&rft.volume=46+Suppl+5&rft.issue=&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Epilepsia&rft.issn=00139580&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-28 N1 - Date created - 2005-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 5-Hydroxytryptophan plus SSRIs for interferon-induced depression: synergistic mechanisms for normalizing synaptic serotonin. AN - 67832394; 15893130 AB - Interferon-alpha (IFN) is widely used in the treatment of certain cancers and viral infections, including hepatitis C (HCV). Unfortunately, depression is a common side effect of IFN therapy, affecting approximately a third of HCV patients receiving IFN therapy. Studies have shown that selective serotonin reuptake inhibitors (SSRIs) can effectively treat IFN-induced depression in only 63-75% of cases. For the remaining percentage, depression often necessitates dose reduction of or discontinuation from IFN therapy. Emerging evidence indicates that IFN may cause depression by affecting brain serotonin. IFN has been shown to increase serotonin reuptake and to decrease serotonin synthesis. We hypothesize that SSRIs are not fully effective because they affect only serotonin reuptake, not serotonin synthesis, and that effective treatment must address both uptake and synthesis. 5-Hydroxytryptophan (5-HTP) effectively increases central nervous system synthesis of serotonin. It is the immediate precursor of serotonin and is widely available as a dietary supplement, which is well absorbed after an oral dose. Several double-blind studies have shown 5-HTP to be effective in the treatment of nondrug-induced depression. We hypothesize that patients who become depressed on IFN will respond to the synergistic combination of SSRIs plus 5-HTP. JF - Medical hypotheses AU - Turner, Erick H AU - Blackwell, Aaron D AD - Mental Health Division, Mood Disorders Research Center, Portland VA Medical Center, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, USA. Erik.turner@med.va.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 138 EP - 144 VL - 65 IS - 1 SN - 0306-9877, 0306-9877 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - Serotonin Uptake Inhibitors KW - Serotonin KW - 333DO1RDJY KW - 5-Hydroxytryptophan KW - C1LJO185Q9 KW - Index Medicus KW - Drug Therapy, Combination KW - Hepatitis C -- drug therapy KW - Synapses -- drug effects KW - Risk Factors KW - Humans KW - Brain Chemistry KW - Serotonin -- metabolism KW - Hepatitis C -- psychology KW - Drug Synergism KW - Models, Biological KW - Depression -- physiopathology KW - Antiviral Agents -- therapeutic use KW - Interferon-alpha -- therapeutic use KW - Interferon-alpha -- adverse effects KW - Serotonin Uptake Inhibitors -- metabolism KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Depression -- drug therapy KW - 5-Hydroxytryptophan -- therapeutic use KW - 5-Hydroxytryptophan -- metabolism KW - Antiviral Agents -- adverse effects KW - Depression -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67832394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+hypotheses&rft.atitle=5-Hydroxytryptophan+plus+SSRIs+for+interferon-induced+depression%3A+synergistic+mechanisms+for+normalizing+synaptic+serotonin.&rft.au=Turner%2C+Erick+H%3BBlackwell%2C+Aaron+D&rft.aulast=Turner&rft.aufirst=Erick&rft.date=2005-01-01&rft.volume=65&rft.issue=1&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Medical+hypotheses&rft.issn=03069877&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-16 N1 - Date created - 2005-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessing the cost-effectiveness of COX-2 specific inhibitors for arthritis in the Veterans Health Administration. AN - 67808222; 15881475 AB - This study was designed to assess the cost-effectiveness of cyclooxygenase-2 specific (COX-2) inhibitors (rofecoxib and celecoxib) over nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) in high-risk arthritis patients from the perspective of the Veterans Health Administration (VA). This literature-based economic analysis (with data summarized from MEDLINE-indexed and other published sources, FDA reports, and data on file at VA San Diego Healthcare System) compared rofecoxib and celecoxib to NSAIDS in two arthritis patient populations considered at higher risk of developing clinically significant upper gastrointestinal events (CSUGIEs): (1) patients of any age with previous medical history of perforation/ulcer/bleed (PUB); and (2) patients 65 years and older (regardless of history of PUB). Two outcome measures were reported: (1) incremental cost per CSUGIE averted over 1 year; and (2) incremental cost per quality-adjusted life-year (QALY) gained, considering both the mortality and morbidity associated with gastrointestinal (including CSUGIEs) and cardiovascular-related adverse events. When possible, costs were modeled to reflect the VA perspective. Sensitivity analyses were conducted to test the robustness of the analysis. Compared to NSAIDS, rofecoxib and celecoxib increased costs but reduced the incidence of CSUGIE. Cost per CSUGIE avoided were $7476 and $16,379 (in patients with a PUB history) and $14,294 and $18,376 (in patients aged > or = 65 years) for celecoxib and rofecoxib, respectively. In both populations, celecoxib was associated with a cost per QALY less than $50,000. In contrast, rofecoxib was found to cost more and result in a net QALY loss, due in particular to the increase in the risk of cardiovascular complications, and was therefore considered cost-ineffective. Results were most dependent on assumptions about the incidence of cardiovascular events and CSUGIE and the COX-2 inhibitors' acquisition price. This analysis suggests that COX-2 inhibitors may be cost-effective from the perspective of the VA. However, cost-effectiveness appears to depend less on the specific characteristics of the high-risk target population considered but more on the agent evaluated. Celecoxib appears to be an alternative to traditional NSAIDs in the patient populations studied. JF - Current medical research and opinion AU - Schaefer, Monica AU - DeLattre, Melissa AU - Gao, Xin AU - Stephens, Jennifer AU - Botteman, Marc AU - Morreale, Anthony AD - VA Kansas City Healthcare System, Kansas City, MO 64128, USA. Monica.Schaefer@med.va.gov Y1 - 2005/01// PY - 2005 DA - January 2005 SP - 47 EP - 60 VL - 21 IS - 1 SN - 0300-7995, 0300-7995 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase Inhibitors KW - Lactones KW - Pyrazoles KW - Sulfonamides KW - Sulfones KW - rofecoxib KW - 0QTW8Z7MCR KW - Celecoxib KW - JCX84Q7J1L KW - Index Medicus KW - United States KW - Pyrazoles -- economics KW - Humans KW - Lactones -- economics KW - Sulfones -- economics KW - Aged KW - Gastrointestinal Diseases -- chemically induced KW - Pyrazoles -- therapeutic use KW - Sulfonamides -- therapeutic use KW - Quality-Adjusted Life Years KW - Lactones -- therapeutic use KW - United States Department of Veterans Affairs KW - Sulfones -- therapeutic use KW - Cost-Benefit Analysis KW - Risk Factors KW - Sulfonamides -- economics KW - Cyclooxygenase Inhibitors -- therapeutic use KW - Cyclooxygenase Inhibitors -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- economics KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Cyclooxygenase Inhibitors -- economics KW - Arthritis -- drug therapy KW - Arthritis -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67808222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+medical+research+and+opinion&rft.atitle=Assessing+the+cost-effectiveness+of+COX-2+specific+inhibitors+for+arthritis+in+the+Veterans+Health+Administration.&rft.au=Schaefer%2C+Monica%3BDeLattre%2C+Melissa%3BGao%2C+Xin%3BStephens%2C+Jennifer%3BBotteman%2C+Marc%3BMorreale%2C+Anthony&rft.aulast=Schaefer&rft.aufirst=Monica&rft.date=2005-01-01&rft.volume=21&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Current+medical+research+and+opinion&rft.issn=03007995&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-02 N1 - Date created - 2005-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The epidemiology of pesticide exposure and cancer: A review. AN - 67749326; 15835496 AB - Cancer is a multifactorial disease with contributions from genetic, environmental, and lifestyle factors. Pesticide exposure is recognized as an important environmental risk factor associated with cancer development. The epidemiology of pesticide exposure and cancer in humans has been studied globally in various settings. Insecticides, herbicides, and fungicides are associated with hemopoetic cancers, and cancers of the prostate, pancreas, liver, and other body systems. The involvement of pesticides in breast cancer has not yet been determined. In developing countries, sufficient epidemiologic research and evidence is lacking to link pesticide exposure with cancer development. Agricultural and industrial workers are high-risk groups for developing cancer following pesticide exposure. Children of farm workers can be exposed to pesticides through their parents. Maternal exposure to pesticides can pose a health risk to the fetus and the newborn. The organophosphates are most the commonly used compounds, but the organochlorines are still permitted for limited use in developing countries. Pesticide exposure, independently or in synergism with modifiable risk factors, is associated with several types of cancer. JF - Reviews on environmental health AU - Jaga, Kushik AU - Dharmani, Chandrabhan AD - Research and Development, VA Hudson Valley Health Care System 2094Albany Post Road, Montrose, New York 10548, USA. Kushik.Jaga@med.va.gov PY - 2005 SP - 15 EP - 38 VL - 20 IS - 1 SN - 0048-7554, 0048-7554 KW - Pesticides KW - 0 KW - Index Medicus KW - Agriculture KW - Humans KW - Risk Assessment KW - Industry KW - Occupational Exposure KW - Pesticides -- poisoning KW - Neoplasms -- epidemiology KW - Environmental Exposure KW - Developing Countries KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67749326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+on+environmental+health&rft.atitle=The+epidemiology+of+pesticide+exposure+and+cancer%3A+A+review.&rft.au=Jaga%2C+Kushik%3BDharmani%2C+Chandrabhan&rft.aulast=Jaga&rft.aufirst=Kushik&rft.date=2005-01-01&rft.volume=20&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Reviews+on+environmental+health&rft.issn=00487554&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-24 N1 - Date created - 2005-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessing contemporary substance abusers with the MMPI MAC Andrews Alcoholism Scale: a review. AN - 67743387; 15830728 AB - We reviewed 71 United States-based MacAndrew Alcoholism Scale (MAC), as revised (MAC-R) studies totaling almost 32,000 Ss, with adolescent and adult substance abusers, from studies published since the last MAC reviews (1989) through 2001. Results suggest that the MAC, and to some extent, the MAC-R, significantly correlates with measures of alcohol and substance abuse in both male and female adolescents and adults, across a diverse spectrum of the use-abuse continuum. Nonclinical groups (100%) scored below the clinical ranges on the MAC/MAC-R, while 79% of adolescent substance abusing groups scored > R 23, indicative of problems with substance abuse. Persons who abused alcohol, drugs, and polydrugs had mean MAC/MAC-R scores > 23, which ranged from 77% to 100% of the cases. The MAC/MAC-R does well in discriminating persons who abuse substances compared to nonclinical, nonabusing groups, but appears to lose diagnostic efficiency with psychiatric patients, and especially with medical patients with seizure disorders. Using R > 25 seems to improve diagnostic accuracy with this population. Meaning of false positives and false negatives were explored and discussed. JF - Substance use & misuse AU - Craig, Robert J AD - Chicago VA Health Care System, West Side Division, Chicago, Illinois 60612, USA. robert.craig2@med.va.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 427 EP - 450 VL - 40 IS - 4 SN - 1082-6084, 1082-6084 KW - Index Medicus KW - Reproducibility of Results KW - Humans KW - Alcoholism -- diagnosis KW - MMPI KW - Psychological Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67743387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+use+%26+misuse&rft.atitle=Assessing+contemporary+substance+abusers+with+the+MMPI+MAC+Andrews+Alcoholism+Scale%3A+a+review.&rft.au=Craig%2C+Robert+J&rft.aulast=Craig&rft.aufirst=Robert&rft.date=2005-01-01&rft.volume=40&rft.issue=4&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Substance+use+%26+misuse&rft.issn=10826084&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-15 N1 - Date created - 2005-04-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical relevance of automated drug alerts from the perspective of medical providers. AN - 67540078; 15782750 AB - The authors used a real-time survey instrument and subsequent focus group among primary care clinicians at a large healthcare system to assess usefulness of automated drug alerts. Of 108 alerts encountered, 0.9% (n = 1) represented critical alerts, and 16% (n = 17) were significant drug interaction alerts. Sixty-one percent (n = 66) involved duplication of a medication or medication class. The rest (n = 24) involved topical medications, inhalers, or vaccines. Of the 84 potentially relevant alerts, providers classified 11% (9/84), or about 1 in 9, as useful. Drug interaction alerts were more often deemed useful than drug duplication alerts (44.4% versus 1.5%, P < .001). Focus group participants generally echoed these results when ranking the relevance of 15 selected alerts, although there was wide variance in ratings for individual alerts. Hence, a "smarter" system that utilizes a set of mandatory alerts while allowing providers to tailor use of other automated warnings may improve clinical relevance of drug alert systems. JF - American journal of medical quality : the official journal of the American College of Medical Quality AU - Spina, Jeffrey R AU - Glassman, Peter A AU - Belperio, Pamela AU - Cader, Rumi AU - Asch, Steven AU - Primary Care Investigative Group of the VA Los Angeles Healthcare System AD - VA Greater Los Angeles Healthcare System-West Los Angeles, CA, USA. jeffrey.spina@med.va.gov ; Primary Care Investigative Group of the VA Los Angeles Healthcare System PY - 2005 SP - 7 EP - 14 VL - 20 IS - 1 SN - 1062-8606, 1062-8606 KW - Index Medicus KW - Focus Groups KW - Medical Records Systems, Computerized KW - Drug Interactions KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Data Collection KW - Pharmacy Service, Hospital KW - Los Angeles KW - Attitude of Health Personnel KW - Clinical Pharmacy Information Systems KW - Medication Errors -- prevention & control KW - Decision Support Systems, Clinical KW - Primary Health Care -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67540078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+medical+quality+%3A+the+official+journal+of+the+American+College+of+Medical+Quality&rft.atitle=Clinical+relevance+of+automated+drug+alerts+from+the+perspective+of+medical+providers.&rft.au=Spina%2C+Jeffrey+R%3BGlassman%2C+Peter+A%3BBelperio%2C+Pamela%3BCader%2C+Rumi%3BAsch%2C+Steven%3BPrimary+Care+Investigative+Group+of+the+VA+Los+Angeles+Healthcare+System&rft.aulast=Spina&rft.aufirst=Jeffrey&rft.date=2005-01-01&rft.volume=20&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=American+journal+of+medical+quality+%3A+the+official+journal+of+the+American+College+of+Medical+Quality&rft.issn=10628606&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-29 N1 - Date created - 2005-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A business case for patient care ergonomic interventions. AN - 67526203; 15779707 AB - This article provides a framework for a business case for patient ergonomic programs that accentuates the financial gains to be realized from such programs as compared to meeting safety requirements. An introduction is made to such commonly used measures as payback period, net present value analysis and internal rate of return. Financial measures on a successful patient handling project in the Veterans Health Administration are outlined and policy implications discussed. JF - Nursing administration quarterly AU - Siddharthan, Kris AU - Nelson, Audrey AU - Weisenborn, Gregory AD - Patient Safety Center of Inquiry, James A. Haley Veterans Administration Medical Center, Tampa, FL 33612, USA. kris.siddharthan@med.va.gov PY - 2005 SP - 63 EP - 71 VL - 29 IS - 1 SN - 0363-9568, 0363-9568 KW - Nursing KW - Humans KW - Cost-Benefit Analysis KW - Models, Econometric KW - Organizational Case Studies KW - Florida KW - Nursing Staff, Hospital KW - Musculoskeletal Diseases -- economics KW - Musculoskeletal Diseases -- prevention & control KW - Occupational Diseases -- economics KW - Occupational Diseases -- prevention & control KW - Hospital Costs KW - Human Engineering -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67526203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+administration+quarterly&rft.atitle=A+business+case+for+patient+care+ergonomic+interventions.&rft.au=Siddharthan%2C+Kris%3BNelson%2C+Audrey%3BWeisenborn%2C+Gregory&rft.aulast=Siddharthan&rft.aufirst=Kris&rft.date=2005-01-01&rft.volume=29&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Nursing+administration+quarterly&rft.issn=03639568&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-22 N1 - Date created - 2005-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Extrapyramidal symptoms with atypical antipsychotics : incidence, prevention and management. AN - 67467431; 15733025 AB - The treatment of schizophrenia changed drastically with the discovery of antipsychotic medications in the 1950s, the release of clozapine in the US in 1989 and the subsequent development of the atypical or novel antipsychotics. These newer medications differ from their conventional counterparts, primarily based on their reduced risk of extrapyramidal symptoms (EPS). EPS can be categorised as acute (dystonia, akathisia and parkinsonism) and tardive (tardive dyskinesia and tardive dystonia) syndromes. They are thought to have a significant impact on subjective tolerability and adherence with antipsychotic therapy in addition to impacting function. Unlike conventional antipsychotic medications, atypical antipsychotics have a significantly diminished risk of inducing acute EPS at recommended dose ranges. These drugs may also have a reduced risk of causing tardive dyskinesia and in some cases may have the ability to suppress pre-existing tardive dyskinesia. This paper reviews the available evidence regarding the incidence of acute EPS and tardive syndromes with atypical antipsychotic therapy. Estimates of incidence are subject to several confounds, including differing methods for detection and diagnosis of EPS, pretreatment effects and issues surrounding the administration of antipsychotic medications. The treatment of acute EPS and tardive dyskinesia now includes atypical antipsychotic therapy itself, although other adjunctive strategies such as antioxidants have also shown promise in preliminary trials. The use of atypical antipsychotics as first line therapy for the treatment of schizophrenia is based largely on their reduced risk of EPS compared with conventional antipsychotics. Nevertheless, EPS with these drugs can occur, particularly when prescribed at high doses. The EPS advantages offered by the atypical antipsychotics must be balanced against other important adverse effects, such as weight gain and diabetes mellitus, now known to be associated with these drugs. JF - Drug safety AU - Pierre, Joseph M AD - David Geffen School of Medicine at UCLA, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA. joseph.pierre2@med.va.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 191 EP - 208 VL - 28 IS - 3 SN - 0114-5916, 0114-5916 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Humans KW - Antipsychotic Agents -- administration & dosage KW - Basal Ganglia Diseases -- drug therapy KW - Basal Ganglia Diseases -- prevention & control KW - Antipsychotic Agents -- adverse effects KW - Basal Ganglia Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67467431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=Extrapyramidal+symptoms+with+atypical+antipsychotics+%3A+incidence%2C+prevention+and+management.&rft.au=Pierre%2C+Joseph+M&rft.aulast=Pierre&rft.aufirst=Joseph&rft.date=2005-01-01&rft.volume=28&rft.issue=3&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=01145916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-26 N1 - Date created - 2005-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacists' and technicians' perceptions and attitudes toward dispensing buprenorphine/ naloxone to patients with opioid dependence. AN - 67458089; 15730114 AB - To assess the perceptions and attitudes of pharmacists and pharmacy technicians involved in an office-based opioid dependence treatment program using buprenorphine/naloxone. Cross-sectional attitudinal assessment. Community, outpatient hospital, and clinic pharmacies. Pharmacists and technicians participating in a clinical trial of opioid dependence treatment using buprenorphine/naloxone. Written and telephone surveys followed by interviews with open-ended items. Attitudes and perceptions regarding opioid-dependent patients and use of buprenorphine/naloxone for treatment of opioid dependence. Pharmacies in seven states (New York, Virginia, Illinois, Florida, Texas, California, and Washington) participated in the clinical trial. A total of 40 pharmacists and pharmacy technicians responded to the initial written survey, representing 27 of the 32 pharmacies (84%). Follow-up interviews were obtained from one individual at 30 of those pharmacies (93.8%). Most pharmacy personnel (77.5%) involved with this study were not more concerned about theft or break-ins and would be willing to participate in opioid dependence treatment as the medication became available commercially (70%). The majority of respondents (85%) indicated that patients did not cause problems at their pharmacies. Compared with their experiences in administering other narcotic medications, most respondents did not express increased concern regarding prescription forgery (75%) or diversion (80%) of buprenorphine/naloxone. The majority of respondents expressed positive attitudes and perceptions regarding patients treated for opioid dependence with buprenorphine/naloxone. JF - Journal of the American Pharmacists Association : JAPhA AU - Raisch, Dennis W AU - Fudala, Paul J AU - Saxon, Andrew J AU - Walsh, Robert AU - Casadonte, Paul AU - Ling, Walter AU - Johnson, Bankole A AU - Malkerneker, Usha AU - Ordorica, Patricia AU - Williford, William O AU - Sather, Mike R AD - Veterans Affairs Cooperative Studies Program, Clinical Research Pharmacy Coordinating Center, Albuquerque, NM 87106, USA. dennis.raisch@csp.research.med.va.gov PY - 2005 SP - 23 EP - 32 VL - 45 IS - 1 SN - 1544-3191, 1544-3191 KW - Drug Combinations KW - 0 KW - Naloxone KW - 36B82AMQ7N KW - Buprenorphine KW - 40D3SCR4GZ KW - Index Medicus KW - United States KW - Pharmaceutical Services -- statistics & numerical data KW - Humans KW - Surveys and Questionnaires KW - Follow-Up Studies KW - Pharmacies -- classification KW - Outpatient Clinics, Hospital KW - Naloxone -- administration & dosage KW - Buprenorphine -- therapeutic use KW - Attitude of Health Personnel KW - Pharmacy Technicians -- psychology KW - Opioid-Related Disorders -- psychology KW - Perception KW - Naloxone -- therapeutic use KW - Buprenorphine -- administration & dosage KW - Pharmacists -- statistics & numerical data KW - Opioid-Related Disorders -- drug therapy KW - Pharmacy Technicians -- statistics & numerical data KW - Pharmacists -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67458089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Pharmacists+Association+%3A+JAPhA&rft.atitle=Pharmacists%27+and+technicians%27+perceptions+and+attitudes+toward+dispensing+buprenorphine%2F+naloxone+to+patients+with+opioid+dependence.&rft.au=Raisch%2C+Dennis+W%3BFudala%2C+Paul+J%3BSaxon%2C+Andrew+J%3BWalsh%2C+Robert%3BCasadonte%2C+Paul%3BLing%2C+Walter%3BJohnson%2C+Bankole+A%3BMalkerneker%2C+Usha%3BOrdorica%2C+Patricia%3BWilliford%2C+William+O%3BSather%2C+Mike+R&rft.aulast=Raisch&rft.aufirst=Dennis&rft.date=2005-01-01&rft.volume=45&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Pharmacists+Association+%3A+JAPhA&rft.issn=15443191&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-25 N1 - Date created - 2005-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Elevated prevalence of hepatitis C infection in users of United States veterans medical centers. AN - 67398766; 15619249 AB - Several studies suggest veterans have a higher prevalence of hepatitis C virus infection than nonveterans, possibly because of military exposures. The purpose of this study was to estimate the prevalence of anti-hepatitis C antibody and evaluate factors associated with infection among users of Department of Veterans Affairs medical centers. Using a two-staged cluster sample, 1288 of 3863 randomly selected veterans completed a survey and underwent home-based phlebotomy for serological testing. Administrative and clinical data were used to correct the prevalence estimate for nonparticipation. The prevalence of antihepatitis C antibody among serology participants was 4.0% (95% CI, 2.6%-5.5%). The estimated prevalence in the population of Veterans Affairs medical center users was 5.4% (95% CI, 3.3%-7.5%) after correction for sociodemographic and clinical differences between participants and nonparticipants. Significant predictors of seropositivity included demographic factors, period of military service (e.g., Vietnam era), prior diagnoses, health care use, and lifestyle factors. At least one traditional risk factor (transfusion or intravenous drug use) was reported by 30.2% of all subjects. Among those testing positive for hepatitis C antibody, 78% either had a transfusion or had used injection drugs. Adjusting for injection drug use and nonparticipation, seropositivity was associated with tattoos and incarceration. Military-related exposures were not found to be associated with infection in the adjusted analysis. In conclusion, the prevalence of hepatitis C in these subjects exceeds the estimate from the general US population by more than 2-fold, likely reflecting more exposure to traditional risk factors among these veterans. JF - Hepatology (Baltimore, Md.) AU - Dominitz, Jason A AU - Boyko, Edward J AU - Koepsell, Thomas D AU - Heagerty, Patrick J AU - Maynard, Charles AU - Sporleder, Jennifer L AU - Stenhouse, Andrew AU - Kling, Mitchel A AU - Hrushesky, William AU - Zeilman, Charles AU - Sontag, Stephen AU - Shah, Nikunj AU - Ona, Fernando AU - Anand, Bhupinder AU - Subik, Marc AU - Imperiale, Thomas F AU - Nakhle, Samer AU - Ho, Sam B AU - Bini, Edmund J AU - Lockhart, Bruce AU - Ahmad, Jawad AU - Sasaki, Anna AU - van der Linden, Brian AU - Toro, Doris AU - Martinez-Souss, Jaime AU - Huilgol, Vivek AU - Eisen, Seth AU - Young, Keith A AD - Epidemiologic Research and Information Center VA Puget Sound Health Care System, Seattle, WA 98108-1597, USA. jason.dominitz@med.va.gov Y1 - 2005/01// PY - 2005 DA - January 2005 SP - 88 EP - 96 VL - 41 IS - 1 SN - 0270-9139, 0270-9139 KW - Index Medicus KW - Prisons KW - Humans KW - Tattooing KW - Aged KW - Cross-Sectional Studies KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Blood Transfusion KW - Middle Aged KW - United States -- epidemiology KW - Female KW - Male KW - Prevalence KW - Substance Abuse, Intravenous KW - Veterans -- statistics & numerical data KW - United States Department of Veterans Affairs KW - Hepatitis C -- etiology KW - Hepatitis C -- epidemiology KW - Hospitals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67398766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Elevated+prevalence+of+hepatitis+C+infection+in+users+of+United+States+veterans+medical+centers.&rft.au=Dominitz%2C+Jason+A%3BBoyko%2C+Edward+J%3BKoepsell%2C+Thomas+D%3BHeagerty%2C+Patrick+J%3BMaynard%2C+Charles%3BSporleder%2C+Jennifer+L%3BStenhouse%2C+Andrew%3BKling%2C+Mitchel+A%3BHrushesky%2C+William%3BZeilman%2C+Charles%3BSontag%2C+Stephen%3BShah%2C+Nikunj%3BOna%2C+Fernando%3BAnand%2C+Bhupinder%3BSubik%2C+Marc%3BImperiale%2C+Thomas+F%3BNakhle%2C+Samer%3BHo%2C+Sam+B%3BBini%2C+Edmund+J%3BLockhart%2C+Bruce%3BAhmad%2C+Jawad%3BSasaki%2C+Anna%3Bvan+der+Linden%2C+Brian%3BToro%2C+Doris%3BMartinez-Souss%2C+Jaime%3BHuilgol%2C+Vivek%3BEisen%2C+Seth%3BYoung%2C+Keith+A&rft.aulast=Dominitz&rft.aufirst=Jason&rft.date=2005-01-01&rft.volume=41&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-02-15 N1 - Date created - 2005-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pathogenesis of esophageal rings in eosinophilic esophagitis. AN - 67342002; 15617859 AB - Eosinophilic esophagitis and eosinophilic gastroenteritis is being recognized more frequently among the adult patients. The disease is characterized by massive infiltration of the wall of gastrointestinal tract by sheets of eosinophils. The clinical features depend upon the site of involvement. They include dyspepsia, dysphagia, nausea, vomiting, chest pain, diarrhea and protein-losing enteropathy. Eosinophilic esophagitis may present as chest pain, dysphagia or dyspepsia. The characteristic endoscopic feature of eosinophilic esophagitis is the formation of fine concentric mucosal rings (corrugated esophagus). Regarding the pathogenesis of these mucosal rings our hypothesis is that mast cells in the esophageal wall in response to allergens release histamine, eosinophilic chemotactic factor and platelet activating factor, etc. which activate eosinophils to release toxic cationic proteins. Activation of acetyl choline by histamine may cause contraction of the muscle fibers in the muscularis mucosae resulting in the formation of esophageal rings. This hypothesis can be tested by demonstrating the contraction of muscle layers of muscularis mucosae with the use of high frequency endoscopic ultrasonic probe introduced via the biopsy channel of an endoscope. JF - Medical hypotheses AU - Mann, N S AU - Leung, J W AD - V.A. Medical Center, 150 Muir Road, Martinez, CA 94553, USA. frances.hill@med.va.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 520 EP - 523 VL - 64 IS - 3 SN - 0306-9877, 0306-9877 KW - Allergens KW - 0 KW - Antimicrobial Cationic Peptides KW - Chemotactic Factors KW - Platelet Activating Factor KW - Histamine KW - 820484N8I3 KW - Acetylcholine KW - N9YNS0M02X KW - Index Medicus KW - Muscle Fibers, Skeletal -- physiology KW - Gastroenteritis -- pathology KW - Platelet Activating Factor -- secretion KW - Humans KW - Histamine -- metabolism KW - Mast Cells -- drug effects KW - Chemotactic Factors -- secretion KW - Acetylcholine -- metabolism KW - Esophagus -- pathology KW - Antimicrobial Cationic Peptides -- secretion KW - Mast Cells -- metabolism KW - Adult KW - Gastroenteritis -- physiopathology KW - Eosinophils -- metabolism KW - Intestinal Mucosa -- pathology KW - Allergens -- pharmacology KW - Muscle Contraction KW - Antimicrobial Cationic Peptides -- toxicity KW - Eosinophilia -- physiopathology KW - Esophagitis -- pathology KW - Esophagitis -- physiopathology KW - Eosinophilia -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67342002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+hypotheses&rft.atitle=Pathogenesis+of+esophageal+rings+in+eosinophilic+esophagitis.&rft.au=Mann%2C+N+S%3BLeung%2C+J+W&rft.aulast=Mann&rft.aufirst=N&rft.date=2005-01-01&rft.volume=64&rft.issue=3&rft.spage=520&rft.isbn=&rft.btitle=&rft.title=Medical+hypotheses&rft.issn=03069877&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-23 N1 - Date created - 2004-12-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Selegiline modifies the extinction of responding following morphine self-administration, but does not alter cue-induced reinstatement, reacquisition of morphine reinforcement, or precipitated withdrawal. AN - 67255536; 15519537 AB - Selegiline is an irreversible inhibitor of monoamine oxidase (MAO) with psychostimulant and neuroprotective effects which can prevent decreases in dopamine efflux that follow opiate withdrawal. The present study evaluated effects of selegiline treatment on morphine-seeking behavior and morphine reinforcement in Wistar rats (n = 26). In additional animals (n = 30), the ability of single doses of selegiline to modify naloxone-precipitated withdrawal was determined. After pretreatment with noncontingent morphine to establish opiate dependence, rats acquired self-administration of intravenous morphine. Daily intravenous treatment with saline or 2.0mg kg(-1) doses of selegiline was then initiated and continued over 14 days during extinction, reinstatement, and reacquisition of morphine self-administration. To reduce the potential for psychostimulant effects, selegiline was administered approximately 1h following self-administration, extinction, or reinstatement sessions. In some animals (n = 23), effects of saline or selegiline administration on locomotor activity were determined following extinction sessions. Daily selegiline treatment decreased the number of ratios completed and increased response latency during extinction, without modifying these measures during reinstatement or reacquisition of morphine self-administration. Chronic selegiline treatment increased locomotor activity recorded between 4 and 7h after selegiline administration on day 7 of extinction, but otherwise did not alter locomotor activity. Pretreatment with single, 2.0mg kg(-1) doses of selegiline did not modify naloxone-precipitated withdrawal. In conclusion, pretreatment with selegiline produced only a small decrease in responding during extinction of morphine self-administration and did not modify cue-induced reinstatement of morphine-seeking behavior, reacquisition or morphine reinforcement, or precipitated withdrawal. JF - Pharmacological research AU - Grasing, Kenneth AU - He, Shaunteng AU - Li, Ning AD - Substance Abuse Research Laboratory, Kansas City Veterans Affairs Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA. kenneth.grasing@med.va.gov Y1 - 2005/01// PY - 2005 DA - January 2005 SP - 69 EP - 78 VL - 51 IS - 1 SN - 1043-6618, 1043-6618 KW - Selegiline KW - 2K1V7GP655 KW - Morphine KW - 76I7G6D29C KW - Index Medicus KW - Rats KW - Animals KW - Self Administration KW - Reinforcement (Psychology) KW - Rats, Wistar KW - Male KW - Selegiline -- pharmacology KW - Selegiline -- therapeutic use KW - Cues KW - Substance Withdrawal Syndrome -- drug therapy KW - Substance Withdrawal Syndrome -- psychology KW - Extinction, Psychological -- physiology KW - Extinction, Psychological -- drug effects KW - Morphine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67255536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+research&rft.atitle=Selegiline+modifies+the+extinction+of+responding+following+morphine+self-administration%2C+but+does+not+alter+cue-induced+reinstatement%2C+reacquisition+of+morphine+reinforcement%2C+or+precipitated+withdrawal.&rft.au=Grasing%2C+Kenneth%3BHe%2C+Shaunteng%3BLi%2C+Ning&rft.aulast=Grasing&rft.aufirst=Kenneth&rft.date=2005-01-01&rft.volume=51&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Pharmacological+research&rft.issn=10436618&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-03-29 N1 - Date created - 2004-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Translating Research into Practice: The Role of Web-Based Education AN - 61379110; 200601981 AB - Clinical Practice Guidelines (CPGs) constitute a major focus of recent efforts to narrow the gap between research and practice. However, CBGs cannot effectively change clinical practice unless they are effectively disseminated. The present article describes a web-based course designed teach nurses about a CPG for the management of alcohol withdrawal. In it, we outline the details of our web-based course, including its technical characteristics, organization, structure, and clinical content. Next, we outline several adjunctive strategies that may improve the effectiveness of such web-based educational interventions. Finally, we discuss other ways that web-based education may prove useful in disseminating evidence-based practices in human service delivery settings. Figures, References. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Technology in Human Services AU - Weingardt, Kenneth R AU - Villafranca, Steven W AD - Center Health Care Evaluation, VA Palo Alto Health Care System, Stanford U School Medicine ken.weingardt@med.va.gov Y1 - 2005///0, PY - 2005 DA - 0, 2005 SP - 259 EP - 273 PB - Haworth Press, Binghamton NY VL - 23 IS - 3-4 SN - 1522-8835, 1522-8835 KW - Clinical practice guideline, web-based intervention, e-learning KW - Human Services KW - Clinical Social Work KW - Research Applications KW - Evidence Based Practice KW - Internet KW - article KW - 6113: social work education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61379110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Technology+in+Human+Services&rft.atitle=Translating+Research+into+Practice%3A+The+Role+of+Web-Based+Education&rft.au=Weingardt%2C+Kenneth+R%3BVillafranca%2C+Steven+W&rft.aulast=Weingardt&rft.aufirst=Kenneth&rft.date=2005-01-01&rft.volume=23&rft.issue=3-4&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Journal+of+Technology+in+Human+Services&rft.issn=15228835&rft_id=info:doi/10.1300%2FJ017v023n03_07 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Number of references - 26 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Human Services; Clinical Social Work; Research Applications; Internet; Evidence Based Practice DO - http://dx.doi.org/10.1300/J017v023n03_07 ER - TY - JOUR T1 - The Struggle to Maintain Neutrality in the Treatment of a Patient with Pedophilia AN - 57139387; 200603295 AB - This article explores the ethical concept of neutrality through use of a psychiatric clinical vignette. In this case a psychiatry resident is faced with the treatment of a patient who was found by the FBI to be in possession of child pornography. Although not accused of any other crimes, the patient was a fugitive from the law & requesting treatment for pedophilia. Faced with the pressures of limited resources & anxiety about the patient's dangerousness to others, the resident & his supervisor tried to strike a balance between the ethical principles of neutrality & beneficence. Through this vignette, the importance of neutrality, as well as how it can be compromised by other pressures such as expediency & anxiety, is explored. 3 References. Adapted from the source document. JF - Ethics & Behavior AU - Lally, Matthew C AU - Freeman, Scott A AD - c/o Freeman -- Mental Health Care Line, Southern Arizona Veterans Affairs Healthcare System, Tucson Y1 - 2005///0, PY - 2005 DA - 0, 2005 SP - 182 EP - 190 VL - 15 IS - 2 SN - 1050-8422, 1050-8422 KW - Ethics KW - Paedophilia KW - Patients KW - Psychiatrists KW - Neutrality KW - Doctor-Patient interactions KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57139387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethics+%26+Behavior&rft.atitle=The+Struggle+to+Maintain+Neutrality+in+the+Treatment+of+a+Patient+with+Pedophilia&rft.au=Lally%2C+Matthew+C%3BFreeman%2C+Scott+A&rft.aulast=Lally&rft.aufirst=Matthew&rft.date=2005-01-01&rft.volume=15&rft.issue=2&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Ethics+%26+Behavior&rft.issn=10508422&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Ethics; Neutrality; Patients; Paedophilia; Psychiatrists; Doctor-Patient interactions ER - TY - JOUR T1 - Improving the Quality of Dementia Care: The Role of Education AN - 57056883; 200616706 AB - The physical, psychosocial & economic burdens of Alzheimer's disease & related dementia are exacerbated by large gaps in the quality of care provided to patients & their family caregivers. The quality improvement programs described in this Special Section represent important contributions to the goal of improving dementia care quality & outcomes. Yet evidence from other chronic diseases suggests that the overall impacts of these programs will be limited: significant, lasting improvements in healthcare quality & outcomes appear to require intensive, multi-level, multifaceted approaches comprising coordinated efforts by a broad spectrum of stakeholders. This Commentary examines the quality improvement programs presented relative to current thinking & insights regarding requirements for successful improvement. The Commentary concludes with a series of recommendations for actions needed to supplement the programs presented here, & to accelerate progress in improving dementia care quality & outcomes for patients, caregivers, & other stakeholders. References. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Clinical Gerontologist AU - Mittman, Brian S AD - Center Study Healthcare Provider Behavior, VA Greater Los Angeles Healthcare System, Sepulveda, CA Brian.Mittman@med.va.gov Y1 - 2005///0, PY - 2005 DA - 0, 2005 SP - 61 EP - 69 PB - The Haworth Press, Binghamton NY VL - 29 IS - 2 SN - 0731-7115, 0731-7115 KW - Dementia, quality of care, physician education, evidence-based medicine, coalitions KW - Evidence based KW - Quality of care KW - Health care KW - Outcomes KW - Dementia KW - Educational programmes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57056883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Gerontologist&rft.atitle=Improving+the+Quality+of+Dementia+Care%3A+The+Role+of+Education&rft.au=Mittman%2C+Brian+S&rft.aulast=Mittman&rft.aufirst=Brian&rft.date=2005-01-01&rft.volume=29&rft.issue=2&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Clinical+Gerontologist&rft.issn=07317115&rft_id=info:doi/10.1300%2FJ018v29n02_07 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-03 N1 - Last updated - 2016-09-27 N1 - CODEN - CLGEDA N1 - SubjectsTermNotLitGenreText - Dementia; Quality of care; Outcomes; Evidence based; Health care; Educational programmes DO - http://dx.doi.org/10.1300/J018v29n02_07 ER - TY - JOUR T1 - Comparison of human turning gait with the mechanical performance of lower limb prosthetic transverse rotation adapters AN - 20433967; 7918266 AB - Given the importance of minimizing transverse plane shear stress on soft tissue, several transverse rotational adapters (TRAs) are available for incorporation in lower limb prostheses. This study compares kinetic and kinematic data from human subjects during straight and turning gaits to the mechanical performance of several TRAs. Physiological data were collected from three individuals walking straight and turning at self-selected speeds around a 1 m radius circle. The average peak torques and range of motion for normal subjects while turning were 8.2 Nm and 26 degree (outside leg), 11.8Nm and 20 degree (inside leg), and 11.4Nm and 20 degree (right leg) during straight gait. Each TRA was mechanically tested without axial loading in a servo-hydraulic material testing system (MTS) over its rotational range at 0.5 degree /s and 60 degree /s. The TRAs with axial compression were also tested at 0.5 degree /s under a 736N (75kg mass) axial load. Applying these torques to the different TRAs yielded 3 to 35 degree rotation, depending on the elastomer installed. Some TRAs had nearly constant stiffness, while others stiffened with rotation. The TRAs also varied in their average maximum stiffness from 0.4Nm/ degree to 2.7Nm/ degree . Normal subjects exhibit interior vs. exterior asymmetrical torques and displacements; however, only one of the TRAs is designed to allow asymmetrical stiffness, and none have asymmetric ranges. Prosthetists and physicians can use these data to better interpret amputees' qualitative remarks and to prescribe the correct TRA and/or elastomer. This information also forms a basis for further design and development of novel torque absorbing prosthetic adapters. JF - Prosthetics and Orthotics International AU - Flick, K C AU - Orendurff AU - Berge, J S AU - Segal, AD AU - Klute, G K AD - Veterans Administration Rehabilitation Research and Development Center for Excellence in Limb Loss Prevention and Prosthetic Engineering, Seattle WA, USA Y1 - 2005 PY - 2005 DA - 2005 SP - 73 EP - 81 VL - 29 IS - 1 SN - 0309-3646, 0309-3646 KW - Physical Education Index KW - Kinematics KW - Flexibility KW - Physiology KW - Orthotics KW - Walking KW - Legs KW - Force KW - Amputees KW - Speed KW - Kinetics KW - Human subjects KW - Work load KW - Physicians KW - Performance KW - Gait KW - Prosthetics KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20433967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prosthetics+and+Orthotics+International&rft.atitle=Comparison+of+human+turning+gait+with+the+mechanical+performance+of+lower+limb+prosthetic+transverse+rotation+adapters&rft.au=Flick%2C+K+C%3BOrendurff%3BBerge%2C+J+S%3BSegal%2C+AD%3BKlute%2C+G+K&rft.aulast=Flick&rft.aufirst=K&rft.date=2005-01-01&rft.volume=29&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Prosthetics+and+Orthotics+International&rft.issn=03093646&rft_id=info:doi/10.1080%2F03093640500088120 LA - English DB - Physical Education Index N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Kinematics; Flexibility; Physiology; Walking; Orthotics; Legs; Force; Amputees; Speed; Human subjects; Kinetics; Physicians; Work load; Performance; Gait; Prosthetics DO - http://dx.doi.org/10.1080/03093640500088120 ER - TY - JOUR T1 - Sonographic NASCET Index: A New Doppler Parameter for Assessment of Internal Carotid Artery Stenosis AN - 20237552; 6164491 AB - BACKGROUND: AND PURPOSE: Established Doppler parameters for carotid stenosis assessment do not reflect North American Symptomatic Carotid Endarterectomy Trial (NASCET)-style methodology. We derived a Doppler parameter, termed sonographic NASCET index (SNI), and hypothesized that the SNI would provide greater angiographic correlation and better accuracy in predicting stenosis of 70% or greater than that of currently used peak systolic velocity (PSV) measurements. METHODS: Inclusion criteria of angiographically proved carotid stenoses of 40-95% and measured proximal and distal internal carotid artery Doppler PSV values were established. Occlusions and near occlusions were specifically excluded. Doppler and angiographic data meeting the inclusion criteria from 32 carotid bifurcations were identified; actual angiographic stenoses ranged 40-89%. SNI values were calculated for each vessel. PSV and SNI were correlated with angiography by using linear regression analysis. Accuracies of SNI and PSV in predicting stenosis of 70% or greater were compared at two thresholds. RESULTS: Correlation between SNI and angiography was superior to that between PSV and angiography (r super(2) = 0.64 vs 0.38). PSV and SNI values that corresponded to 70% angiographic stenosis were 345 cm/s and 45.5, respectively. Accuracy of PSV of 345 cm/s or greater in predicting stenosis of 70% or greater was 78%, compared with 88% for SNI of 45.5 or greater. The SNI value that corresponded to a PSV threshold of 250 cm/s was 33. Accuracy of PSV of 250 cm/s or greater in predicting stenosis of 70% or greater was 81%, compared with 88% for SNI of 33 or greater. CONCLUSION: Correlation between SNI and angiography was greater than that between PSV and angiography. Accuracy of SNI in predicting stenosis of 70% or greater was also superior to that of PSV at two thresholds. These results suggest that SNI may be a better predictor of high-grade carotid stenosis than is PSV. JF - American Journal of Neuroradiology AU - Hathout, Gasser M AU - Fink, James R AU - El-Saden, Suzie M AU - Grant, Edward G AD - Department of Radiology, University of California at Los Angeles. Department of Radiology, West Los Angeles Veterans Administration Medical Center. Department of Radiology, University of Southern California Medical Center, Los Angeles, CA Y1 - 2005/01// PY - 2005 DA - Jan 2005 SP - 68 EP - 75 PB - American Society of Neuroradiology, 2210 Midwest Rd. Ste. 207 Oak Brood IL 60521 USA, [mailto:ajnr@interaccess.com] VL - 26 IS - 1 SN - 0195-6108, 0195-6108 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Angiography KW - Data processing KW - Occlusion KW - Stenosis KW - Carotid artery KW - Regression analysis KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20237552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Neuroradiology&rft.atitle=Sonographic+NASCET+Index%3A+A+New+Doppler+Parameter+for+Assessment+of+Internal+Carotid+Artery+Stenosis&rft.au=Hathout%2C+Gasser+M%3BFink%2C+James+R%3BEl-Saden%2C+Suzie+M%3BGrant%2C+Edward+G&rft.aulast=Hathout&rft.aufirst=Gasser&rft.date=2005-01-01&rft.volume=26&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Neuroradiology&rft.issn=01956108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Angiography; Data processing; Occlusion; Regression analysis; Carotid artery; Stenosis ER - TY - JOUR T1 - Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice AN - 19807193; 6432292 AB - Genetic murine models play an important role in the study of human neurological disorders by providing accurate and experimentally accessible systems to study pathogenesis and to test potential therapeutic treatments. One of the most widely employed models of Huntington's disease (HD) is the R6/2 transgenic mouse. To characterize this model further, we have performed behavioral and neuropathological analyses that provide a foundation for the use of R6/2 mice in preclinical therapeutic trials. Behavioral analyses of the R6/2 mouse reveal age-related impairments in dystonic movements, motor performance, grip strength, and body weight that progressively worsen until death. Significant neuropathological sequela, identified as increasing marked reductions in brain weight, are present from 30 days, whereas decreased brain volume is present from 60 days and decreased neostriatal volume and striatal neuron area, with a concomitant reduction in striatal neuron number, are present at 90 days of age. Huntingtin-positive aggregates are present at postnatal day 1 and increase in number and size with age. Our findings suggest that the R6/2 HD model exhibits a progressive HD-like behavioral and neuropathological phenotype that more closely corresponds to human HD than previously believed, providing further assurance that the R6/2 mouse is an appropriate model for testing potential therapies for HD. JF - Journal of Comparative Neurology AU - Stack, Edward C AU - Kubilus, James K AU - Smith, Karen AU - Cormier, Kerry AU - Signore, Steven JDel AU - Guelin, Emmanuel AU - Ryu, Hoon AU - Hersch, Steven M AU - Ferrante, Robert J AD - Geriatric Research Education and Clinical Center, Bedford Veterans Administration Medical Center, Bedford, Massachusetts 01730, rjferr@bu.edu Y1 - 2005 PY - 2005 DA - 2005 SP - 354 EP - 370 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 490 IS - 4 SN - 0021-9967, 0021-9967 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Huntington's disease KW - temporal phenotype KW - R6/2 transgenic mice KW - huntingtin KW - Age KW - Neurological diseases KW - Body weight KW - Neurons KW - Neostriatum KW - Motor task performance KW - Animal models KW - Brain KW - Transgenic mice KW - W 30925:Genetic Engineering KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19807193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Comparative+Neurology&rft.atitle=Chronology+of+behavioral+symptoms+and+neuropathological+sequela+in+R6%2F2+Huntington%27s+disease+transgenic+mice&rft.au=Stack%2C+Edward+C%3BKubilus%2C+James+K%3BSmith%2C+Karen%3BCormier%2C+Kerry%3BSignore%2C+Steven+JDel%3BGuelin%2C+Emmanuel%3BRyu%2C+Hoon%3BHersch%2C+Steven+M%3BFerrante%2C+Robert+J&rft.aulast=Stack&rft.aufirst=Edward&rft.date=2005-01-01&rft.volume=490&rft.issue=4&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=Journal+of+Comparative+Neurology&rft.issn=00219967&rft_id=info:doi/10.1002%2Fcne.20680 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Huntington's disease; Age; Neurological diseases; Body weight; Neurons; Motor task performance; Neostriatum; Brain; Animal models; Transgenic mice DO - http://dx.doi.org/10.1002/cne.20680 ER - TY - JOUR T1 - Monomeric endotoxin:protein complexes are essential for TLR4-dependent cell activation AN - 17876474; 6263300 AB - Potent TLR4-dependent cell activation by Gram-negative bacterial endotoxin depends on sequential endotoxin-protein and protein-protein interactions with LBP, CD14, MD-2 and TLR4. LBP and CD14 combine, in an albumin-dependent fashion, to extract single endotoxin molecules from purified endotoxin aggregates (E sub(agg)) or the bacterial outer membrane and form monomeric endotoxin:CD14 complexes that are the preferred presentation of endotoxin for transfer to MD-2. Endotoxin in endotoxin:CD14 is readily transferred to MD-2, again in an albumin-dependent manner, to form monomeric endotoxin:MD-2 complex. This monomeric endotoxin:protein complex (endotoxin:MD-2) activates TLR4 at picomolar concentrations, independently of albumin, and is, therefore, the apparent ligand in endotoxin-dependent TLR4 activation. Tetra-, penta-, and hexa-acylated forms of meningococcal endotoxin (LOS) react similarly with LBP, CD14, and MD-2 to form endotoxin:MD-2 complexes. However, tetra- and penta-acylated LOS:MD-2 complexes are less potent TLR4 agonists than hexa-acylated LOS:MD-2. This is mirrored in the reduced activity of tetra-, penta- versus hexa-acylated LOS aggregates (LOS sub(agg)) + LBP toward cells containing mCD14, MD-2, and TLR4. Therefore, changes in agonist potency of under-acylated meninigococcal LOS are determined by differences in properties of monomeric endotoxin:MD-2. JF - Journal of Endotoxin Research AU - Gioannini, T L AU - Teghanemt, A AU - Zhang, D AU - Levis, EN AU - Weiss, J P AD - Departments of Internal Medicine, and Biochemistry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa and the Veterans' Administration Medical Center, Iowa City, IA 52241, USA, theresa-gioannini@uiowa.edu Y1 - 2005 PY - 2005 DA - 2005 SP - 117 EP - 123 VL - 11 IS - 2 SN - 0968-0519, 0968-0519 KW - Microbiology Abstracts B: Bacteriology KW - Endotoxins KW - Outer membranes KW - Albumin KW - CD14 antigen KW - TLR4 protein KW - Protein interaction KW - Toll-like receptors KW - Cell activation KW - J 02822:Biosynthesis and physicochemical properties KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17876474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Endotoxin+Research&rft.atitle=Monomeric+endotoxin%3Aprotein+complexes+are+essential+for+TLR4-dependent+cell+activation&rft.au=Gioannini%2C+T+L%3BTeghanemt%2C+A%3BZhang%2C+D%3BLevis%2C+EN%3BWeiss%2C+J+P&rft.aulast=Gioannini&rft.aufirst=T&rft.date=2005-01-01&rft.volume=11&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Journal+of+Endotoxin+Research&rft.issn=09680519&rft_id=info:doi/10.1179%2F096805105X35198 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Endotoxins; TLR4 protein; Toll-like receptors; CD14 antigen; Cell activation; Albumin; Outer membranes; Protein interaction DO - http://dx.doi.org/10.1179/096805105X35198 ER - TY - JOUR T1 - Benzodiazepines and injury: a risk adjusted model AN - 17568018; 6458943 AB - Background Benzodiazepines (BZD) are one class of medications that are generally acknowledged to be a risk factor for injuries. Objective Our objective was to link outpatient prescription data with clinical data in order to develop a risk adjusted binary model that associates BZD usage with the risk for a healthcare encounter for an injury. Methods In total, 3 years of outpatient BZD prescription data, totaling 133 872 outpatient BZD prescriptions for 13 745 patients for a VA medical center, were combined with data from inpatient and outpatient administrative databases. The model incorporated Elixhauser comorbidity measures with 1-year look back period, along with hospital discharges, marital status, age, mean arterial pressure and body mass index. The model also included the dose of the drug, converted to valium equivalents and its duration. The model was analyzed using generalized estimation equations (GEE). Results Dose, duration, discharges and various comorbidities were associated with an increased risk for injury, while being married reduced the risk. Increased body mass was associated with increased injury risk. Increased mean arterial pressure was associated with decreased risk. Conclusions These findings offer guidance on how specific combinations of risk factors and potential protective effects may impact accidental injury risk. Clinicians prescribing or adjusting BZDs can use these results to more accurately tailor medication regimens for a patient. Our findings suggest that clinicians should also consider the nature of the social support system available to the patient in assessing total injury risk. JF - Pharmacoepidemiology and Drug Safety AU - French, D D AU - Campbell, R AU - Spehar, A AU - Angaran, D M AD - VISN-8 Measurement Support Team, 11605 N Nebraska Ave., Tampa, FL 33612, USA, Dustin.French@med.va.gov Y1 - 2005/01// PY - 2005 DA - Jan 2005 SP - 17 EP - 24 VL - 14 IS - 1 SN - 1053-8569, 1053-8569 KW - benzodiazepines KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Injuries KW - Body mass KW - Blood pressure KW - Models KW - Mathematics KW - Databases KW - valium KW - Risk factors KW - Benzodiazepine KW - Body size KW - Body mass index KW - Drugs KW - Side effects KW - Hospitals KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17568018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Benzodiazepines+and+injury%3A+a+risk+adjusted+model&rft.au=French%2C+D+D%3BCampbell%2C+R%3BSpehar%2C+A%3BAngaran%2C+D+M&rft.aulast=French&rft.aufirst=D&rft.date=2005-01-01&rft.volume=14&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.967 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Databases; valium; Injuries; Body mass; Risk factors; Benzodiazepine; Body mass index; Drugs; Blood pressure; Hospitals; Mathematics; Models; Body size; Side effects DO - http://dx.doi.org/10.1002/pds.967 ER - TY - JOUR T1 - Embolic stroke complicating Staphylococcus aureusendocarditis circumstantially linked to rectal trauma from foreign body: a first case report AN - 17494769; 6271563 AB - Background: Diagnostic and therapeutic instrumentation of the lower gastrointestinal tract has been reported to result in bacteremia and endocarditis. No such case has been reported in persons with a history of rectal foreign body insertion despite its potential for greater trauma. Case presentation: A 58-year-old male was admitted with confusion and inability to speak. His past history was notable for hospitalization to extract a retained plastic soda bottle from the rectosigmoid two years prior. On examination, he was febrile, tachycardic and hypotensive. There was an apical pansystolic murmur on cardiac examination. He had a mixed receptive and expressive aphasia, and a right hemiparesis. On rectal examination he had perianal erythema and diminished sphincter tone. Magnetic resonance imaging of the brain showed infarction of the occipital and frontal lobes. Transesophageal Echocardiography of the heart revealed vegetations on the mitral valve. All of his blood culture bottles grew methicillin sensitive Staphylococcus aureus. He was successfully treated for bacterial endocarditis with intravenous nafcillin and gentamicin. The rectum is frequently colonized by Staphylococcus aureus and trauma to its mucosa can lead to bacteremia and endocarditis with this organism. In the absence of corroborative evidence such as presented here, it is difficult to make a correlation between staphylococcal endocarditis and anorectal foreign body insertion due to patients being less than forthcoming Conclusions: There is a potential risk of staphylococcal bacteremia and endocarditis with rectal foreign body insertion. Further studies are needed to explore this finding. Detailed sexual history and patient counseling should be made a part of routine primary care. JF - BMC Infectious Diseases AU - Pandey, B B AU - Dang, T C AU - Healy, J F Y1 - 2005 PY - 2005 DA - 2005 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 5 KW - Microbiology Abstracts B: Bacteriology KW - Heart KW - Neuroimaging KW - Intravenous administration KW - Rectum KW - Magnetic resonance imaging KW - sphincter KW - Stroke KW - Echocardiography KW - Mucosa KW - Vegetation KW - Bacteremia KW - Trauma KW - Endocarditis KW - Gentamicin KW - Digestive tract KW - Case reports KW - Frontal lobe KW - Staphylococcus aureus KW - aphasia KW - Foreign bodies KW - Cerebral infarction KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17494769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Infectious+Diseases&rft.atitle=Embolic+stroke+complicating+Staphylococcus+aureusendocarditis+circumstantially+linked+to+rectal+trauma+from+foreign+body%3A+a+first+case+report&rft.au=Pandey%2C+B+B%3BDang%2C+T+C%3BHealy%2C+J+F&rft.aulast=Pandey&rft.aufirst=B&rft.date=2005-01-01&rft.volume=5&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Infectious+Diseases&rft.issn=1471-2334&rft_id=info:doi/10.1186%2F1471-2334-5-42 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Heart; Intravenous administration; Neuroimaging; Rectum; Mucosa; Echocardiography; Stroke; sphincter; Magnetic resonance imaging; Bacteremia; Vegetation; Endocarditis; Trauma; Gentamicin; Digestive tract; Case reports; Frontal lobe; aphasia; Foreign bodies; Cerebral infarction; Staphylococcus aureus DO - http://dx.doi.org/10.1186/1471-2334-5-42 ER - TY - JOUR T1 - Three Surveillance Strategies for Vancomycin-Resistant Enterococci in Hospitalized Patients: Detection of Colonization Efficiency and a Cost- Effectiveness Model AN - 17370828; 6474679 AB - To evaluate the cost-effectiveness and detection sensitivity associated with three active surveillance strategies for the identification of patients harboring vancomycin-resistant enterococci (VRE) to determine which is the most medically and economically useful. Culture for VRE from 200 consecutive stool specimens submitted for Clostridium difficile culture. Following this, risk factors were assessed for patients whose culture yielded VRE, and a cost-effectiveness evaluation was performed using a decision analytic model with a probabilistic analysis. A 688-bed, tertiary-care facility in Chicago, Illinois, with approximately 39,000 annual admissions, 7,000 newborn deliveries, 56,000 emergency department visits, and 115,000 home care and 265,000 outpatient visits. All stool specimens submitted to the clinical microbiology laboratory for C. difficile culture from hospital inpatients. From 200 stool samples submitted for C. difficile testing, we identified 5 patients with VRE in non-high-risk areas not screened as part of our routine patient surveillance. Medical record review revealed that all 5 had been hospitalized within the prior 2 years. Three of 5 had a history of renal impairment. The strategy that would involve screening the greatest number of patients (all those with a history of hospital admission in the prior 2 years) resulted in highest screening cost per patient admitted ($2.48), lower per patient admission costs ($480), and the best survival rates. An expanded VRE surveillance program that encompassed all patients hospitalized within the prior 2 years was a cost-effective screening strategy compared with a more traditional one focused on high-risk units. JF - Infection Control and Hospital Epidemiology AU - Lee, T A AU - Hacek, D M AU - Stroupe, K T AU - Collins, S M AU - Peterson, L R AD - Midwest Center for Health Services and Policy Research, Hines VA Hospital, PO Box 5000 (151-H), Hines, IL 60141, USA, todd.lee@med.va.gov Y1 - 2005/01// PY - 2005 DA - Jan 2005 SP - 39 EP - 46 VL - 26 IS - 1 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology KW - Colonization KW - medical records KW - Risk factors KW - Kidney KW - Survival KW - Risk groups KW - Clostridium difficile KW - Neonates KW - Feces KW - Hospitals KW - Models KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17370828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Three+Surveillance+Strategies+for+Vancomycin-Resistant+Enterococci+in+Hospitalized+Patients%3A+Detection+of+Colonization+Efficiency+and+a+Cost-+Effectiveness+Model&rft.au=Lee%2C+T+A%3BHacek%2C+D+M%3BStroupe%2C+K+T%3BCollins%2C+S+M%3BPeterson%2C+L+R&rft.aulast=Lee&rft.aufirst=T&rft.date=2005-01-01&rft.volume=26&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Colonization; medical records; Risk factors; Kidney; Risk groups; Survival; Neonates; Feces; Models; Hospitals; Clostridium difficile ER - TY - JOUR T1 - Concurrent Outbreak of Multidrug-Resistant and Susceptible Subclones of Acinetobacter baumannii Affecting Different Wards of a Single Hospital AN - 17368636; 6474681 AB - Acinetobacter baumannii has emerged as an opportunistic pathogen among acutely ill patients, especially those with thermal injury. A prospective 8-month study was conducted to describe the clinical and molecular epidemiology of multidrug-resistant A. baumannii affecting a single hospital. Univariate analysis comparing Smal macrorestriction patterns of A. baumannii generated by pulsed-field gel electrophoresis (PFGE) versus clinical and demographic risk factors. A total of 200 isolates from 76 patients were collected, of which 185 isolates from 76 patients were analyzed by PFGE. A total of 17 distinct PFGE clonal types were identified. One clonal type (strain A) represented 129 isolates from 49 patients. A group of related clonal types (strain A variants) were identified as 40 isolates from 20 patients. The only risk factor other than geographic location associated with the presence of strain A was prior treatment with antibiotics active against gram-negative bacteria (P = .0015). The two clonal types differed in antibiotic resistance profiles: 25% of strain A isolates, the dominant strain in the burn unit, were susceptible to at least one antibiotic tested. In contrast, approximately 80% of the other strain types were susceptible to at least one antibiotic and were cultured from patients admitted elsewhere in the hospital. No combination of antibiotics was observed to yield additive or synergistic activity. Clonally related strains of Acinetobacter that differ in susceptibility patterns may coexist within a single hospital, dependent on the selective pressure related to antibiotic exposure. JF - Infection Control and Hospital Epidemiology AU - Maslow, J N AU - Glaze, T AU - Adams, P AU - Lataillade, M AD - ACOS for Research, VA Medical Center (151), University and Woodland Avenues, Philadelphia, PA 19104, USA, Joel.Maslow@med.va.gov Y1 - 2005/01// PY - 2005 DA - Jan 2005 SP - 69 EP - 75 VL - 26 IS - 1 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology KW - Demography KW - Thermal injury KW - Acinetobacter baumannii KW - Epidemiology KW - Risk factors KW - Gram-negative bacteria KW - Pulsed-field gel electrophoresis KW - Antibiotics KW - Burns unit KW - Antibiotic resistance KW - Hospitals KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17368636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Concurrent+Outbreak+of+Multidrug-Resistant+and+Susceptible+Subclones+of+Acinetobacter+baumannii+Affecting+Different+Wards+of+a+Single+Hospital&rft.au=Maslow%2C+J+N%3BGlaze%2C+T%3BAdams%2C+P%3BLataillade%2C+M&rft.aulast=Maslow&rft.aufirst=J&rft.date=2005-01-01&rft.volume=26&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Demography; Thermal injury; Epidemiology; Gram-negative bacteria; Risk factors; Pulsed-field gel electrophoresis; Burns unit; Antibiotics; Antibiotic resistance; Hospitals; Acinetobacter baumannii ER - TY - JOUR T1 - Family history of suicidal behavior and earlier onset of suicidal behavior. AN - 67175401; 15590049 AB - The study examined whether having a family history of suicidal behavior is associated with an earlier age of first attempting suicide. Interviews were conducted with 545 patients who had attempted suicide about their family history of suicidal behavior and about their age of first suicide attempt. The results showed that attempters with a family history of suicidal behavior, particularly attempters with two or more such family members, had first attempted suicide at an earlier age than attempters who did not have a family history of suicidal behavior. These results suggest that a family history of suicide, which is known to increase the risk of suicidal behavior, may also be associated with an earlier age of first attempting suicide. JF - Psychiatry research AU - Roy, Alec AD - Psychiatry Service 116A, Department of Veterans Affairs, New Jersey Healthcare System, 385 Tremont Avenue, East Orange, NJ 07018, USA. Alec.Roy@med.va.gov Y1 - 2004/12/15/ PY - 2004 DA - 2004 Dec 15 SP - 217 EP - 219 VL - 129 IS - 2 SN - 0165-1781, 0165-1781 KW - Index Medicus KW - Substance-Related Disorders -- diagnosis KW - Age of Onset KW - Humans KW - Adult KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Male KW - Female KW - Diagnostic and Statistical Manual of Mental Disorders KW - Suicide, Attempted -- statistics & numerical data KW - Suicide, Attempted -- psychology KW - Self-Injurious Behavior -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67175401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Family+history+of+suicidal+behavior+and+earlier+onset+of+suicidal+behavior.&rft.au=Roy%2C+Alec&rft.aulast=Roy&rft.aufirst=Alec&rft.date=2004-12-15&rft.volume=129&rft.issue=2&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-10 N1 - Date created - 2004-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Contagious acute gastrointestinal infections. AN - 67134844; 15575058 JF - The New England journal of medicine AU - Musher, Daniel M AU - Musher, Benjamin L AD - Medical Service, Infectious Disease Section, Michael E. DeBakey Veterans Affairs Medical Center, and the Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. daniel.musher@med.va.gov Y1 - 2004/12/02/ PY - 2004 DA - 2004 Dec 02 SP - 2417 EP - 2427 VL - 351 IS - 23 KW - Abridged Index Medicus KW - Index Medicus KW - Protozoan Infections -- parasitology KW - Acute Disease KW - Virus Diseases -- transmission KW - Bacterial Infections -- microbiology KW - Bacterial Infections -- prevention & control KW - Humans KW - Foodborne Diseases -- complications KW - Virus Diseases -- prevention & control KW - Virus Diseases -- virology KW - Protozoan Infections -- prevention & control KW - Bacterial Infections -- transmission KW - Communicable Diseases -- microbiology KW - Communicable Diseases -- parasitology KW - Gastrointestinal Diseases -- parasitology KW - Gastrointestinal Diseases -- microbiology KW - Gastrointestinal Diseases -- prevention & control KW - Communicable Diseases -- transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67134844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Contagious+acute+gastrointestinal+infections.&rft.au=Musher%2C+Daniel+M%3BMusher%2C+Benjamin+L&rft.aulast=Musher&rft.aufirst=Daniel&rft.date=2004-12-02&rft.volume=351&rft.issue=23&rft.spage=2417&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-08 N1 - Date created - 2004-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 2005 Mar 24;352(12):1267-8; author reply 1267-8 [15788508] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Efficacy and tolerability of memantine in the treatment of dementia. AN - 67304810; 15903287 AB - Until recently, acetylcholinesterase inhibitors were the only approved agents for the treatment of Alzheimer's disease (AD). These medications have also been used in the treatment of vascular dementia (VD). Memantine, the first N-methyl-D-aspartate (NMDA)-receptor antagonist to be well tolerated, has been approved for the treatment of moderate to severe AD. The aim of this study was to review the current literature on the efficacy and tolerability of memantine in the treatment of AD and VD. A MEDLINE search of the English-language literature from January 1970 to March 2004 was conducted to identify randomized, double-blind, placebo-controlled, parallel-group trials in which memantine was administered to patients with VD or AD. The search terms were memantine, NMDA inhibitor, and NMDA antagonist. Excessive glutamate, the brain's major excitatory neurotransmitter, can cause excitotoxicity by allowing too much calcium to enter neuronal cells. Moderate-affinity NMDA-receptor antagonists such as memantine block pathologic activity of glutamate while allowing physiologic activity. Use of memantine has been associated with significant improvements in measures of cognition, function, and behavior in both VD and AD. Adverse events associated with memantine have been comparable to those with placebo, with the exception of an increased incidence of dizziness, constipation, cataracts, nausea, dyspnea, confusion, headache, and urinary incontinence. Memantine seems to be promising and well tolerated in the treatment of moderate to severe VD or AD, either as monotherapy or in combination with donepezil. It appears to be particularly effective in improving cognitive, functional, and global outcomes in moderate to severe AD and in improving cognitive end points in mild to moderate VD. More research is needed on important clinical questions, including whether memantine can prolong patients' ability to provide self-care and delay institutional placement. JF - The American journal of geriatric pharmacotherapy AU - Rossom, Rebecca AU - Adityanjee AU - Dysken, Maurice AD - Minneapolis Veterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota 55417, USA. rebecca.rossom@med.va.gov Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 303 EP - 312 VL - 2 IS - 4 SN - 1543-5946, 1543-5946 KW - Receptors, N-Methyl-D-Aspartate KW - 0 KW - Memantine KW - W8O17SJF3T KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Aged KW - Dementia, Vascular -- drug therapy KW - Memantine -- therapeutic use KW - Alzheimer Disease -- drug therapy KW - Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors KW - Memantine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67304810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+geriatric+pharmacotherapy&rft.atitle=Efficacy+and+tolerability+of+memantine+in+the+treatment+of+dementia.&rft.au=Rossom%2C+Rebecca%3BAdityanjee%3BDysken%2C+Maurice&rft.aulast=Rossom&rft.aufirst=Rebecca&rft.date=2004-12-01&rft.volume=2&rft.issue=4&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+geriatric+pharmacotherapy&rft.issn=15435946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-28 N1 - Date created - 2005-05-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recent quitters' interest in recycling and harm reduction. AN - 67285311; 15801581 AB - Many smoking cessation attempts are followed by failure or relapse. The optimal time to initiate a new quit attempt is not known. Administrative databases documenting recent use of a pharmacological aid for smoking cessation provide access to a population of smokers recently in the action phase of quitting. This study describes interest in further treatment among this population. A total of 2,340 smokers from the Minneapolis Veterans Administration Medical Center received prescriptions for a smoking cessation aid during an 18-month period. We conducted a cross-sectional survey of a random sample of this population a minimum of 3 months following the prescription, using a structured telephone interview (N=391). The response rate was 75.8%. The 1-month point-prevalent abstinence rate was 19.7%. Of continuing smokers, 98% were willing to make another quit attempt--50% immediately, and 28% within 1 month. There was no relationship between time since the last quit attempt and interest in trying again immediately. Some 95% of continuing smokers were willing to try a reduction strategy. Of these, 82.7% were interested in using nicotine replacement therapy (NRT) to accomplish this goal. Most cessation programs do not systematically approach participants who relapse. These data suggest that this population would welcome further help in quitting or reducing smoking shortly following failure, and that smokers do not commonly relapse to a precontemplation stage of change. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Joseph, Anne M AU - Rice, Kathryn AU - An, Lawrence C AU - Mohiuddin, Asra AU - Lando, Harry AD - Minneapolis Veterans Affairs Medical Center, Center for Chronic Disease Outcomes Research of Health Services Research and Development, and University of Minnesota Medical School, Minneapolis, Minnesota 55417, USA. Anne.M.Joseph@med.va.gov Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 1075 EP - 1077 VL - 6 IS - 6 SN - 1462-2203, 1462-2203 KW - Dopamine Uptake Inhibitors KW - 0 KW - Ganglionic Stimulants KW - Bupropion KW - 01ZG3TPX31 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Administration, Cutaneous KW - Bupropion -- therapeutic use KW - Databases as Topic KW - Humans KW - Aged KW - Dopamine Uptake Inhibitors -- therapeutic use KW - Recurrence KW - Cross-Sectional Studies KW - Aged, 80 and over KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Female KW - Male KW - Nicotine -- therapeutic use KW - Harm Reduction KW - Tobacco Use Disorder -- drug therapy KW - Smoking Cessation -- methods KW - Ganglionic Stimulants -- therapeutic use KW - Nicotine -- administration & dosage KW - Tobacco Use Disorder -- prevention & control KW - Smoking -- prevention & control KW - Ganglionic Stimulants -- administration & dosage KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67285311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Recent+quitters%27+interest+in+recycling+and+harm+reduction.&rft.au=Joseph%2C+Anne+M%3BRice%2C+Kathryn%3BAn%2C+Lawrence+C%3BMohiuddin%2C+Asra%3BLando%2C+Harry&rft.aulast=Joseph&rft.aufirst=Anne&rft.date=2004-12-01&rft.volume=6&rft.issue=6&rft.spage=1075&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-10 N1 - Date created - 2005-04-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models. AN - 67236470; 15681801 AB - Both oxidative damage and inflammation are elevated in brains of Alzheimer's disease (AD) patients, but their pathogenic significance remains unclear. The reduced AD risk associated with high intake of both nonsteroidal anti-inflammatory drugs (NSAIDs) and antioxidants suggests causal roles, but clinical trials in AD patients have yielded only limited or negative results. To test the potential efficacy and mechanisms of candidate approaches, we have explored conventional and unconventional NSAIDs, antioxidants, and combined NSAID/antioxidants in cell culture and animal models for AD (including aging APPsw transgenic mice and soluble Abeta rodent infusion models). The conventional NSAID ibuprofen has the strongest epidemiological support. At sustainable doses designed to mimic protective consumption in the epidemiology, ibuprofen reduces amyloid accumulation but suppresses a surprisingly limited subset of inflammatory markers in APPsw transgenic mice. Both Ab production (APP, beta- and gamma-secretases) and post-production pathways (those affecting Abeta aggregation or clearance: e.g., IL-1 or alpha1ACT) are potentially involved in ibuprofen and other NSAID anti-AD activities. The post-production pathways are predictably shared with other seemingly protective NSAIDs, including naproxen that do not lower Abeta42 in vitro. Using clinically feasible dosing, brain levels of NSAIDs appear too low to implicate a number of pharmacological dose targets that have been demonstrated in vitro. Ibuprofen did not suppress microglial markers related to phagocytosis. The putative anti-inflammatory omega-3 fatty acid DHA had a profound impact on pathogenesis but did not lower inflammation, while vitamin E was surprisingly ineffective in reducing oxidative damage or amyloid in the aged APPsw mouse. In contrast, the unconventional NSAID/antioxidant curcumin was effective, lowering oxidative damage, cognitive deficits, synaptic marker loss, and amyloid deposition. Curcumin proved to be immunomodulatory, simultaneously inhibiting cytokine and microglial activation indices related to neurotoxicity, but increasing an index of phagocytosis. Curcumin directly targeted Abeta and was also effective in other models, warranting further preclinical and clinical exploration. JF - Annals of the New York Academy of Sciences AU - Cole, Greg M AU - Morihara, Takashi AU - Lim, Giselle P AU - Yang, Fusheng AU - Begum, Aynun AU - Frautschy, Sally A AD - Greater Los Angeles Healthcare System, Veterans Administration Medical Center, North Hills, CA 91343, USA. gmcole@ucla.edu Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 68 EP - 84 VL - 1035 SN - 0077-8923, 0077-8923 KW - Amyloid beta-Protein Precursor KW - 0 KW - Anti-Inflammatory Agents, Non-Steroidal KW - Antioxidants KW - Fatty Acids, Omega-3 KW - Index Medicus KW - Animals KW - Fatty Acids, Omega-3 -- therapeutic use KW - Humans KW - Signal Transduction -- drug effects KW - In Vitro Techniques KW - Inflammation -- drug therapy KW - Disease Models, Animal KW - Amyloid beta-Protein Precursor -- metabolism KW - Models, Biological KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Antioxidants -- therapeutic use KW - Alzheimer Disease -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67236470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=NSAID+and+antioxidant+prevention+of+Alzheimer%27s+disease%3A+lessons+from+in+vitro+and+animal+models.&rft.au=Cole%2C+Greg+M%3BMorihara%2C+Takashi%3BLim%2C+Giselle+P%3BYang%2C+Fusheng%3BBegum%2C+Aynun%3BFrautschy%2C+Sally+A&rft.aulast=Cole&rft.aufirst=Greg&rft.date=2004-12-01&rft.volume=1035&rft.issue=&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-13 N1 - Date created - 2005-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cigarette smoking exacerbates chronic alcohol-induced brain damage: a preliminary metabolite imaging study. AN - 67183251; 15608601 AB - Cigarette smoking is common among alcohol-dependent individuals. Nevertheless, previous research has typically not accounted for the potential independent or compounding effects of cigarette smoking on alcohol-induced brain injury and neurocognition. Twenty-four 1-week-abstinent recovering alcoholics (RAs; 14 smokers and 10 nonsmokers) in treatment and 26 light-drinking controls (7 smokers and 19 nonsmokers) were compared on measures of common brain metabolites in gray matter and white matter of the major lobes, basal ganglia, midbrain, and cerebellar vermis, obtained via multislice short-echo time proton magnetic resonance spectroscopic imaging. Smoking and nonsmoking RAs were also contrasted on measures of neurocognitive functioning, as well as laboratory markers of drinking severity and nutritional status. Chronic alcohol dependence, independent of smoking, was associated with lower concentrations of frontal N-acetylaspartate (NAA) and frontal choline-containing compounds, as well as lower parietal and thalamic choline. Smoking RAs had lower NAA concentrations in frontal white matter and midbrain and lower midbrain choline than nonsmoking RAs. A four-group analysis of covariance also demonstrated that chronic cigarette smoking was associated with lower midbrain NAA and choline and with lower vermian choline. In smoking RAs, heavier drinking was associated with heavier smoking, which correlated with numerous subcortical metabolite abnormalities. The 1-week-abstinent smoking and nonsmoking RAs did not differ significantly on a brief neurocognitive battery. In smoking RAs, lower cerebellar vermis NAA was associated with poorer visuomotor scanning speed and incidental learning, and in nonsmoking RAs lower vermis NAA was related to poorer visuospatial learning and memory. These human in vivo proton magnetic resonance spectroscopic imaging findings indicate that chronic cigarette smoking exacerbates chronic alcohol-induced neuronal injury and cell membrane damage in the frontal lobes of RAs and has independent adverse effects on neuronal viability and cell membranes in the midbrain and on cell membranes of the cerebellar vermis. Higher smoking levels are associated with metabolite concentrations in select subcortical structures. Greater consideration of the potential effects of comorbid cigarette smoking on alcohol-induced brain damage and other diseases affecting the central nervous system is warranted. JF - Alcoholism, clinical and experimental research AU - Durazzo, Timothy C AU - Gazdzinski, Stefan AU - Banys, Peter AU - Meyerhoff, Dieter J AD - San Francisco Veterans Administration Medical Center, MRS Unit (114M), 4150 Clement St., San Francisco, CA 94121, USA. timothy.durazzo@med.va.gov Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 1849 EP - 1860 VL - 28 IS - 12 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Cognition -- physiology KW - Magnetic Resonance Spectroscopy -- statistics & numerical data KW - Analysis of Variance KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Brain -- metabolism KW - Male KW - Female KW - Alcohol-Induced Disorders, Nervous System -- metabolism KW - Alcohol-Induced Disorders, Nervous System -- complications KW - Smoking -- metabolism KW - Alcoholism -- metabolism KW - Brain Damage, Chronic -- metabolism KW - Brain Damage, Chronic -- etiology KW - Temperance -- statistics & numerical data KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67183251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Cigarette+smoking+exacerbates+chronic+alcohol-induced+brain+damage%3A+a+preliminary+metabolite+imaging+study.&rft.au=Durazzo%2C+Timothy+C%3BGazdzinski%2C+Stefan%3BBanys%2C+Peter%3BMeyerhoff%2C+Dieter+J&rft.aulast=Durazzo&rft.aufirst=Timothy&rft.date=2004-12-01&rft.volume=28&rft.issue=12&rft.spage=1849&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-03-22 N1 - Date created - 2004-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of a data warehouse to examine the effect of fluoroquinolones on glucose metabolism. AN - 67176214; 15595230 JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Coblio, Nicholas A AU - Mowrey, Kim AU - McCright, Paul AU - Means, Heidi AU - McCormick, Michael T AD - Pharmacy Department (119), James A. Haley Veterans Affairs Medical Center, 13000 Bruce B. Downs Boulevard, Tampa, FL 33612, USA. Nicholas.Coblio@med.va.gov Y1 - 2004/12/01/ PY - 2004 DA - 2004 Dec 01 SP - 2545 EP - 2548 VL - 61 IS - 23 SN - 1079-2082, 1079-2082 KW - Anti-Infective Agents KW - 0 KW - Blood Glucose KW - Fluoroquinolones KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Diabetes Mellitus -- metabolism KW - Blood Glucose -- metabolism KW - Hyperglycemia -- chemically induced KW - Humans KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Hypoglycemia -- chemically induced KW - Male KW - Female KW - Fluoroquinolones -- adverse effects KW - Anti-Infective Agents -- adverse effects KW - Glucose -- metabolism KW - Databases, Factual UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67176214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Use+of+a+data+warehouse+to+examine+the+effect+of+fluoroquinolones+on+glucose+metabolism.&rft.au=Coblio%2C+Nicholas+A%3BMowrey%2C+Kim%3BMcCright%2C+Paul%3BMeans%2C+Heidi%3BMcCormick%2C+Michael+T&rft.aulast=Coblio&rft.aufirst=Nicholas&rft.date=2004-12-01&rft.volume=61&rft.issue=23&rft.spage=2545&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-02-23 N1 - Date created - 2004-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tiotropium bromide. AN - 67175259; 15596697 AB - Tiotropium bromide is a novel, inhaled, once-daily anticholinergic bronchodilator that has recently been approved in the United States for use in patients with COPD. Its unique feature is the persistence of bronchodilation for > 24 h due to prolonged M(3) muscarinic receptor blockade. Tiotropium provides significant improvement in spirometry and lung volumes. Clinically relevant outcomes such as the relief of dyspnea, improvement in the quality of life (health status), and reductions in the frequency and severity of acute exacerbations have been consistently obtained with tiotropium in clinical trials. In head-to-head trials, tiotropium administered once daily resulted in bronchodilation (peak, trough, and area under the curve) that was statistically superior to ipratropium administered four times daily and salmeterol administered twice daily. Clinical outcomes (dyspnea, quality of life, exacerbation frequency) were numerically but not always statistically better with tiotropium than salmeterol. Long-term studies of the combination of tiotropium with adrenergic agents, methylxanthines, or inhaled corticosteroids have not been reported in full. Several 1-year studies demonstrate that the only significant side effect of tiotropium was dryness of the mouth, which occurred in approximately 10 to 16% of patients; it is well tolerated by patients and safe. JF - Chest AU - Gross, Nicholas J AD - Hines VA Hospital, PO Box 1485, Hines, IL 60141, USA. Nicholas.gross@med.va.gov Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 1946 EP - 1953 VL - 126 IS - 6 SN - 0012-3692, 0012-3692 KW - Bronchodilator Agents KW - 0 KW - Cholinergic Antagonists KW - Scopolamine Derivatives KW - Tiotropium Bromide KW - XX112XZP0J KW - Abridged Index Medicus KW - Index Medicus KW - Acute Disease KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Quality of Life KW - Bronchi -- drug effects KW - Lung -- physiopathology KW - Scopolamine Derivatives -- therapeutic use KW - Bronchodilator Agents -- pharmacology KW - Bronchodilator Agents -- therapeutic use KW - Scopolamine Derivatives -- adverse effects KW - Cholinergic Antagonists -- therapeutic use KW - Pulmonary Disease, Chronic Obstructive -- physiopathology KW - Pulmonary Disease, Chronic Obstructive -- drug therapy KW - Cholinergic Antagonists -- pharmacology KW - Scopolamine Derivatives -- pharmacology KW - Cholinergic Antagonists -- adverse effects KW - Bronchodilator Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67175259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Tiotropium+bromide.&rft.au=Gross%2C+Nicholas+J&rft.aulast=Gross&rft.aufirst=Nicholas&rft.date=2004-12-01&rft.volume=126&rft.issue=6&rft.spage=1946&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-01-18 N1 - Date created - 2004-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evidence for bidirectional cues as a function of time following treatment with amphetamine: implications for understanding tolerance and withdrawal. AN - 67158669; 15582685 AB - Previous drug-discrimination studies have focused on characterizing the cue properties associated with amphetamine's (AMPH) primary effect. Results from recent experiments indicate that equally prominent cues are associated with AMPH withdrawal. The purpose of the present study was to investigate the extent to which AMPH-induced withdrawal cues, opposite to those associated with AMPH's primary effect are observed. Since dopamine (DA) has been implicated in mediating the AMPH cue, rats were trained to discriminate between 0.25 mg/kg AMPH, an indirect DA agonist, and 0.033 mg/kg haloperidol (HAL), a DA antagonist at the D2 receptor site. Training doses were chosen so that rats responded about equally on both levers when tested on saline (SAL) providing a behavioral baseline sensitive to assessing AMPH-related bidirectional changes in cue state. Following acquisition of the discrimination, rats were tested for choice of responding on the AMPH and HAL levers at intervals from 6 to 72 h following treatment with a single dose of 3.0 mg/AMPH. Also, in order to investigate the relationship between withdrawal and tolerance to AMPH's cue properties, AMPH dose-response curves were determined 24 h following treatment with SAL, 1.5 and 3.0 mg/kg AMPH. At short intervals after treatment with 3.0 mg/kg AMPH, rats responded primarily on the AMPH lever followed by a shift to predominant responding on the HAL lever 16-30 h post-treatment, before returning to predrug levels. Treatment with 1.5 and 3.0 mg/kg AMPH produced parallel dose-response curve shifts to the right. Following a single dose of AMPH, robust cues associated with AMPH withdrawal were observed that lasted approximately three times longer than the cues associated with the drug's primary effects. Furthermore, results from the tolerance tests indicate that tolerance reflects a baseline shift rather than a loss in drug efficacy. JF - Pharmacology, biochemistry, and behavior AU - Barrett, Robert J AU - Caul, William F AU - Smith, Randy L AD - Veterans Administration Medical Center, Departments of Psychology and Pharmacology, Vanderbilt University, Research Service (151), 1310 24th Avenue South, Nashville, TN 37212-2637, USA. r2k2@comcast.net Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 761 EP - 771 VL - 79 IS - 4 SN - 0091-3057, 0091-3057 KW - Amphetamine KW - CK833KGX7E KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Time Factors KW - Male KW - Reaction Time -- drug effects KW - Drug Tolerance -- physiology KW - Cues KW - Substance Withdrawal Syndrome -- psychology KW - Amphetamine -- pharmacology KW - Reaction Time -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67158669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Evidence+for+bidirectional+cues+as+a+function+of+time+following+treatment+with+amphetamine%3A+implications+for+understanding+tolerance+and+withdrawal.&rft.au=Barrett%2C+Robert+J%3BCaul%2C+William+F%3BSmith%2C+Randy+L&rft.aulast=Barrett&rft.aufirst=Robert&rft.date=2004-12-01&rft.volume=79&rft.issue=4&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-29 N1 - Date created - 2004-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Carisoprodol withdrawal syndrome. AN - 67157246; 15585447 AB - A 43-year-old man with chronic back and shoulder pain was treated with hydrocodone. He began taking excessive amounts of the drug, so his physicians stopped prescribing it. The patient then obtained the muscle relaxant carisoprodol on his own from several sources. He was consuming up to 30 or more tablets/day (> or =10,500 mg/day) for several weeks, then abruptly stopped taking the drug. Within 48 hours he developed anxiety, tremors, muscle twitching, insomnia, auditory and visual hallucinations, and bizarre behavior. The symptoms intensified and peaked on the fourth day after carisoprodol cessation. The patient required brief treatment with olanzapine and tapering dosages of lorazepam while the symptoms gradually resolved. To our knowledge, this is the first documented case of a withdrawal syndrome with carisoprodol. The symptoms most likely resulted because of accumulation of meprobamate, the active metabolite of carisoprodol in humans. Clinicians prescribing carisoprodol should be aware of the possibility for abuse or addiction. Further, we recommend that carisoprodol be designated a controlled substance at the federal level. JF - Pharmacotherapy AU - Reeves, Roy R AU - Beddingfield, John J AU - Mack, James E AD - G.V. (Sonny) Montgomery VA Medical Center, School of Medicine, University of Mississippi, Jackson, Mississippi, USA. roy.reeves@med.va.gov Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 1804 EP - 1806 VL - 24 IS - 12 SN - 0277-0008, 0277-0008 KW - Carisoprodol KW - 21925K482H KW - Index Medicus KW - Humans KW - Adult KW - Male KW - Carisoprodol -- adverse effects KW - Substance Withdrawal Syndrome -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67157246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Carisoprodol+withdrawal+syndrome.&rft.au=Reeves%2C+Roy+R%3BBeddingfield%2C+John+J%3BMack%2C+James+E&rft.aulast=Reeves&rft.aufirst=Roy&rft.date=2004-12-01&rft.volume=24&rft.issue=12&rft.spage=1804&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-01-26 N1 - Date created - 2004-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Behavioral interventions for dual-diagnosis patients. AN - 67089221; 15550289 AB - Dual diagnosis patients come to treatment with a variety of deficits,talents, and motivations. A biopsychosocial treatment plan involves multiple interventions, including medications, medical treatment, psychotherapy, family therapy, housing, and vocational rehabilitation. Treatment must be individualized and integrated, and this requires collaboration among a variety of health caregivers. There is empirical evidence that dual-diagnosis patients can be helped to stabilize, to remain in the community,and even to enter the workforce. Behavioral interventions are key ingredients to integrated and comprehensive treatment planning. There is no single model for dual disorders that explains why substance use and psychiatric illness co-occur so frequently. Mueser et al described four theoretical models accounting for the increased rates of comorbidity between psychiatric disorders and substance use disorders. They suggested that there could be a common factor that accounts for both, primary psychiatric disorder causing secondary substance abuse, primary substance abuse causing secondary psychiatric disorder, or a bidirectional problem, where each contributes to the other. There is evidence for each, although some are more compelling than others, and none is so compelling that it stands alone. Although family studies and genetic research could explain the common factor, no common gene has appeared. Antisocial personality disorder has been associated with very high rates of substance use disorders and mental illness; however, its prevalence is too low to explain most of the co-occurring phenomena. Common neurobiology, specifically the dopamine-releasing neurons in the mesolimbic system, also may be involved in mental illness, but this is not compelling at the moment. The Self-medication model is very appealing to mental health professionals, as an explanation for the secondary substance abuse model. Mueser et al suggest that three lines of evidence would be present to support this explanation: (1) patients would report beneficial effects of substance use on their symptoms; (2) epidemiology would report that a specific substance would be used by specific psychiatric disorders, and (3) psychiatric patients with severe symptoms would be more likely to abuse substances than those with mild symptoms. Unfortunately the research data do not support these. The primary substance abuse causing secondary psychiatric disorder model could be explained by neuronal kindling from substance-induced disorders. Patients who develop the psychiatric disorder after the substance use disorder do have a course of illness similar to those with a psychiatric disorder, but without substance use disorder. The bidirectional model is consistent with the tendency of disturbed teenagers to socialize with youth using alcohol and drugs; however, this model has not been tested rigorously in research studies. With such a disparate set of models, behavior interventions are conceptualized best as a multi-component program, a treatment plan that generates a problem list and devises an intervention to respond to each member of the list. This requires a talented, multi-disciplinary team or network that can assess carefully and package the interventions creatively, and dose the treatment components empathically to fit the patient's tolerance, motivation, and abilities. JF - The Psychiatric clinics of North America AU - Goldsmith, R Jeffrey AU - Garlapati, Vamsi AD - Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0559, USA. jeffrey.goldsmith@med.va.gov Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 709 EP - 725 VL - 27 IS - 4 SN - 0193-953X, 0193-953X KW - Index Medicus KW - Motivation KW - Housing KW - Humans KW - Family Therapy -- methods KW - Diagnosis, Dual (Psychiatry) KW - Employment KW - Comorbidity KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Mental Disorders -- diagnosis KW - Mental Disorders -- therapy KW - Mental Disorders -- epidemiology KW - Behavior Therapy -- methods KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67089221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Psychiatric+clinics+of+North+America&rft.atitle=Behavioral+interventions+for+dual-diagnosis+patients.&rft.au=Goldsmith%2C+R+Jeffrey%3BGarlapati%2C+Vamsi&rft.aulast=Goldsmith&rft.aufirst=R&rft.date=2004-12-01&rft.volume=27&rft.issue=4&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=The+Psychiatric+clinics+of+North+America&rft.issn=0193953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-02-03 N1 - Date created - 2004-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of D-cycloserine on negative symptoms in schizophrenia. AN - 66957878; 15474895 AB - The negative and cognitive symptoms of schizophrenia are poorly responsive to neuroleptic treatment. Glutamatergic dysfunction may mediate some of these symptoms. Low dose D-cycloserine (DCS) is a partial agonist at the glycine site of the NMDA-associated receptor complex, noncompetitively enhancing NMDA neurotransmission. Prior studies suggest a beneficial effect of DCS on negative symptoms and cognition. This treatment trial was initiated to confirm and extend these findings. Twenty-two male schizophrenic subjects displaying prominent negative symptoms who were stabilized on typical neuroleptics completed the study. A randomized double-blind parallel group design was used to compare the effects of 50 mg p.o. QD of DCS to placebo over 4 weeks. The two subject groups did not differ significantly in age, age of onset of illness or time on current neuroleptic treatment. Symptoms were rated by means of the SANS, BPRS and Abrams and Taylor rating scale. Cognition was assessed with the Sternberg Memory Test and the Continuous Performance Test. Both medication groups improved over the 4 weeks of treatment. However, there were no significant differences between the DCS and placebo group on any symptom rating. DCS effects on cognition did not differ from placebo. This study did not detect improvement in negative symptoms or cognitive performance with DCS treatment that has been found in some prior studies. This negative finding may be attributed to small sample size, relatively short duration of treatment and the overall modest effect of DCS. Future studies of DCS should be adequately powered to detect a small to medium effect size and should provide for a longer treatment phase than was used in this study in order to avoid a type II error. JF - Schizophrenia research AU - Duncan, Erica J AU - Szilagyi, Sandor AU - Schwartz, Marion P AU - Bugarski-Kirola, Dragana AU - Kunzova, Alena AU - Negi, Shobhit AU - Stephanides, Myrsini AU - Efferen, Toby R AU - Angrist, Burt AU - Peselow, Eric AU - Corwin, June AU - Gonzenbach, Stephen AU - Rotrosen, John P AD - Atlanta Veterans Affairs Medical Center/Emory University School of Medicine, Atlanta, GA 30033, USA. erica.duncan2@med.va.gov Y1 - 2004/12/01/ PY - 2004 DA - 2004 Dec 01 SP - 239 EP - 248 VL - 71 IS - 2-3 SN - 0920-9964, 0920-9964 KW - Antimetabolites KW - 0 KW - Antipsychotic Agents KW - Receptors, N-Methyl-D-Aspartate KW - Cycloserine KW - 95IK5KI84Z KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Severity of Illness Index KW - Drug Administration Schedule KW - Double-Blind Method KW - Receptors, N-Methyl-D-Aspartate -- drug effects KW - Humans KW - Glycine -- metabolism KW - Middle Aged KW - Neuropsychological Tests KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Antimetabolites -- pharmacology KW - Cognition Disorders -- diagnosis KW - Affect -- drug effects KW - Antipsychotic Agents -- blood KW - Cycloserine -- administration & dosage KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenia -- diagnosis KW - Antimetabolites -- administration & dosage KW - Schizophrenia -- drug therapy KW - Cycloserine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66957878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+research&rft.atitle=Effects+of+D-cycloserine+on+negative+symptoms+in+schizophrenia.&rft.au=Duncan%2C+Erica+J%3BSzilagyi%2C+Sandor%3BSchwartz%2C+Marion+P%3BBugarski-Kirola%2C+Dragana%3BKunzova%2C+Alena%3BNegi%2C+Shobhit%3BStephanides%2C+Myrsini%3BEfferen%2C+Toby+R%3BAngrist%2C+Burt%3BPeselow%2C+Eric%3BCorwin%2C+June%3BGonzenbach%2C+Stephen%3BRotrosen%2C+John+P&rft.aulast=Duncan&rft.aufirst=Erica&rft.date=2004-12-01&rft.volume=71&rft.issue=2-3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+research&rft.issn=09209964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-03-01 N1 - Date created - 2004-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Low Testosterone Is Associated with Decreased Function and Increased Mortality Risk: A Preliminary Study of Men in a Geriatric Rehabilitation Unit AN - 20713573; 6227945 AB - Objectives: To evaluate whether low testosterone levels are associated with greater depression or poorer function in a geriatric rehabilitation unit. Design: Retrospective review. Setting: Geriatric rehabilitation unit. Measurements: Low testosterone levels were defined as total testosterone of 3.0 ng-mL or less or free testosterone of 9.0 pg-mL or less. Age, ethnicity, weight, depression, ambulation, length of rehabilitation, and 6-month rehospitalization and mortality rates were obtained. Overall illness severity was determined using the Cumulative Illness Rating Scale for Geriatrics. Results: Low testosterone levels were present in 29 of 44 (65.9%) men. There were no significant differences between men with low and normal testosterone levels in ethnicity, age, weight, depression, and overall illness severity. Lower testosterone levels were correlated with decreased ability to ambulate and transfer (Spearman P>.34; P<.05). There were no significant differences between men with low and normal testosterone in length of stay on the rehabilitation unit (mean plus or minus standard deviation= 19.6 plus or minus 11.6 vs 17.7 plus or minus 17.5 days, P=.68) or rehospitalization rates (41.4% vs 26.7%; P=.34). Men with low testosterone had a trend toward increased 6-month mortality (31.0% vs 6.7%; chi super(2)=3.3, P=.07) and shorter survival time (log rank=3.2; df 1, P=.07). After entering testosterone and variables with potential prognostic significance for mortality in a stepwise manner in a Cox regression analysis, there was a significant mortality risk associated with low testosterone (hazard ratio=27.9, 95% confidence interval=2.0-384.0; P=.01). Conclusion: Low testosterone levels were correlated with decreased physical function and increased risk for 6-month mortality. Prospective studies with larger sample sizes and better standardized testosterone measures are needed to confirm these findings. JF - Journal of the American Geriatrics Society AU - Shores, Molly M AU - Moceri, Victoria M AU - Gruenewald, David A AU - Brodkin, Kayla I AU - Matsumoto, Alvin M AU - Kivlahan, Daniel R AD - Molly M. Shores, MD, VA Puget Sound Health Care System, 1660 S. Columbian Way, S-182 GRECC, Seattle, WA 98108, molly.shores@med.va.gov Y1 - 2004/12// PY - 2004 DA - Dec 2004 SP - 2077 EP - 2081 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 52 IS - 12 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - Mortality KW - Age KW - Reviews KW - males KW - Standards KW - survival KW - depression KW - Ethnic groups KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20713573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Low+Testosterone+Is+Associated+with+Decreased+Function+and+Increased+Mortality+Risk%3A+A+Preliminary+Study+of+Men+in+a+Geriatric+Rehabilitation+Unit&rft.au=Shores%2C+Molly+M%3BMoceri%2C+Victoria+M%3BGruenewald%2C+David+A%3BBrodkin%2C+Kayla+I%3BMatsumoto%2C+Alvin+M%3BKivlahan%2C+Daniel+R&rft.aulast=Shores&rft.aufirst=Molly&rft.date=2004-12-01&rft.volume=52&rft.issue=12&rft.spage=2077&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2004.52562.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - SuppNotes - Figures, 1; tables, 2; references, 30. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Age; Reviews; males; Standards; survival; depression; Ethnic groups DO - http://dx.doi.org/10.1111/j.1532-5415.2004.52562.x ER - TY - JOUR T1 - Chlamydial infection in women along the US-Mexico border AN - 17800463; 6130227 AB - Few studies have reported on sexually transmitted infections at the US-Mexico border, so the prevalence of Chlamydia trachomatis in this population remains uncertain. This binational project investigated the prevalence of, and risk factors for, C. trachomatis among women along the Arizona, US-Sonora, Mexico border. Women who self-referred for routine gynaecological care were invited to complete an interviewer-administered questionnaire and to undergo a Pap smear, C. trachomatis test, and HPV test. In 2270 women, C. trachomatis prevalence overall was 8.2% as measured by hybrid capture and 2.6% by enzyme immunoassay. Infection was associated with young age, a history of new sexual partner(s) in the previous three months, HPV infection, and proximity of clinic to the international border. Antibiotic use in the previous 30 days was associated with decreased odds of infection. Women in Arizona-Sonora border communities are at increased risk for C. trachomatis infection compared to women attending clinics in non-border locations. JF - International Journal of STD & AIDS AU - Baldwin, S B AU - Djambazov, B AU - Papenfuss, M AU - Abrahamsen, M AU - Denman, C AU - de Zapien, JG AU - Ortega, L AU - Henze, JLN AU - Hunter, J AU - Rojas, M AU - Garcia, F AU - Giuliano, A R AD - Veterans Health Administration of Greater Los Angeles, Sepulveda Ambulatory Care Center, 16111 Plummer St, Sepulveda, CA, USA, sbaldwin@mednet.ucla.edu Y1 - 2004/12// PY - 2004 DA - Dec 2004 SP - 815 EP - 821 VL - 15 IS - 12 SN - 0956-4624, 0956-4624 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Age KW - Chlamydia trachomatis KW - Antibiotics KW - Enzyme immunoassay KW - USA KW - Mexico KW - Risk factors KW - Hybrids KW - Ethnic groups KW - Human papillomavirus KW - V 22123:Epidemiology KW - J 02849:Sexually-transmitted diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17800463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+STD+%26+AIDS&rft.atitle=Chlamydial+infection+in+women+along+the+US-Mexico+border&rft.au=Baldwin%2C+S+B%3BDjambazov%2C+B%3BPapenfuss%2C+M%3BAbrahamsen%2C+M%3BDenman%2C+C%3Bde+Zapien%2C+JG%3BOrtega%2C+L%3BHenze%2C+JLN%3BHunter%2C+J%3BRojas%2C+M%3BGarcia%2C+F%3BGiuliano%2C+A+R&rft.aulast=Baldwin&rft.aufirst=S&rft.date=2004-12-01&rft.volume=15&rft.issue=12&rft.spage=815&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+STD+%26+AIDS&rft.issn=09564624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human papillomavirus; Chlamydia trachomatis; USA; Mexico; Age; Ethnic groups; Antibiotics; Enzyme immunoassay; Hybrids; Risk factors ER - TY - JOUR T1 - Use of Translational Fusion of the MrpH Fimbrial Adhesin-Binding Domain with the Cholera Toxin A2 Domain, Coexpressed with the Cholera Toxin B Subunit, as an Intranasal Vaccine To Prevent Experimental Urinary Tract Infection by Proteus mirabilis AN - 17758993; 6093185 AB - This is a follow-up to our previous study using an intranasal vaccine composed of MrpH, the tip adhesin of the MR/P fimbria, and cholera toxin to prevent urinary tract infection by Proteus mirabilis (X. Li, C. V. Lockatell, D. E. Johnson, M. C. Lane, J. W. Warren, and H. L. Mobley, Infect. Immun. 72:66-75, 2004). Here, we have expressed a cholera toxin-like chimera in which the MrpH adhesin-binding domain (residues 23 to 157) replaces the cholera toxin A1 ADP- ribosyltransferase domain. This chimera, when administered intranasally without additional adjuvant, is sufficient to induce protective immunity in mice. JF - Infection and Immunity AU - Li, Xin AU - Erbe, Jarrod L AU - Lockatell, CVirginia AU - Johnson, David E AU - Jobling, Michael G AU - Holmes, Randall K AU - Mobley, Harry LT AD - Department of Microbiology and Immunology, University of Maryland School of Medicine. Division of Research Affairs, Veterans Administration Hospital, Baltimore, Maryland. Y1 - 2004/12// PY - 2004 DA - Dec 2004 SP - 7306 EP - 7310 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 72 IS - 12 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Adhesins KW - Adjuvants KW - Urinary tract KW - Proteus mirabilis KW - Pili KW - Cholera toxin KW - cholera toxin B subunit KW - Cholera KW - Vaccines KW - J 02834:Vaccination and immunization KW - F 06807:Active immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17758993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Use+of+Translational+Fusion+of+the+MrpH+Fimbrial+Adhesin-Binding+Domain+with+the+Cholera+Toxin+A2+Domain%2C+Coexpressed+with+the+Cholera+Toxin+B+Subunit%2C+as+an+Intranasal+Vaccine+To+Prevent+Experimental+Urinary+Tract+Infection+by+Proteus+mirabilis&rft.au=Li%2C+Xin%3BErbe%2C+Jarrod+L%3BLockatell%2C+CVirginia%3BJohnson%2C+David+E%3BJobling%2C+Michael+G%3BHolmes%2C+Randall+K%3BMobley%2C+Harry+LT&rft.aulast=Li&rft.aufirst=Xin&rft.date=2004-12-01&rft.volume=72&rft.issue=12&rft.spage=7306&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Proteus mirabilis; Cholera toxin; Vaccines; Urinary tract; cholera toxin B subunit; Adhesins; Adjuvants; Cholera; Pili ER - TY - JOUR T1 - Risk factors and mortality associated with Clostridium difficile- associated diarrhoea at a VA hospital open] AN - 17695352; 6103471 AB - The objective of this study was to evaluate the risk of certain patient co- morbidities and antibiotics in the development of Clostridium difficile- associated diarrhoea (CDAD). Hospitalized patients developing CDAD during a specified period were compared with a cohort of patients, matched by age, without a diagnosis of CDAD, who were hospitalized during the same time period. Data collection included demographics, hospital ward, co-morbid conditions, antibiotics received, and mortality. Gender and age were similar in both groups. Co-morbid conditions significantly associated with the case group included cancer and COPD. The most commonly prescribed antibiotics in the case versus control group included levofloxacin, intravenous vancomycin, clindamycin, and piperacillin/tazobactam. The case group was associated with a higher mortality rate. JF - International Journal of Antimicrobial Agents AU - Changela, U AU - Cannon, J P AU - Aneziokoro, C AU - Shah, P S AU - Thottapurathu, L AU - Lentino, J AD - Pharmacy Services, Edward Hines Jr. VA Hospital, Fifth Avenue and Roosevelt Road, Building 200, Room 1243, Hines, IL 60141, USA, joseph.lentino@med.va.gov Y1 - 2004/12// PY - 2004 DA - Dec 2004 SP - 562 EP - 566 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 24 IS - 6 SN - 0924-8579, 0924-8579 KW - Microbiology Abstracts B: Bacteriology KW - Clostridium difficile KW - Antibiotics KW - Mortality KW - Risk factors KW - Clindamycin KW - Age KW - Levofloxacin KW - Tazobactam KW - Data collections KW - Morbidity KW - Antimicrobial agents KW - Demography KW - Gender KW - Vancomycin KW - Piperacillin KW - Hospitals KW - J 02846:Gastrointestinal tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17695352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Antimicrobial+Agents&rft.atitle=Risk+factors+and+mortality+associated+with+Clostridium+difficile-+associated+diarrhoea+at+a+VA+hospital+open%5D&rft.au=Changela%2C+U%3BCannon%2C+J+P%3BAneziokoro%2C+C%3BShah%2C+P+S%3BThottapurathu%2C+L%3BLentino%2C+J&rft.aulast=Changela&rft.aufirst=U&rft.date=2004-12-01&rft.volume=24&rft.issue=6&rft.spage=562&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Antimicrobial+Agents&rft.issn=09248579&rft_id=info:doi/10.1016%2Fj.ijantimicag.2004.07.011 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Mortality; Age; Clindamycin; Levofloxacin; Antibiotics; Tazobactam; Data collections; Morbidity; Antimicrobial agents; Demography; Risk factors; Gender; Vancomycin; Piperacillin; Hospitals; Clostridium difficile DO - http://dx.doi.org/10.1016/j.ijantimicag.2004.07.011 ER - TY - JOUR T1 - Excimer laser ablation for valvular angioplasty in pulmonary atresia and intact ventricular septum AN - 17391963; 6473045 AB - The prognosis for infants with pulmonary atresia and intact ventricular septum (PA/IVS) is poor and they present a major management challenge. Mechanical penetration of the atretic pulmonary valve is an applicable option for decompression of the right ventricle and optimization of left ventricular function. The utilization of laser energy for debulking and vaporization of the atretic valve tissue is a relevant approach due to the potential for controlled, precise mode of energy distribution. A 4-month-old female with PA/IVS whose failure to thrive was accompanied by critical hemodynamic abnormalities received successful percutaneous pulmonary valve plate ablation by a 0.9 mm pulsed-wave ultraviolet excimer laser catheter (308 nm wavelength, fluence 50 mJ/mm super(2); 30 Hz). A "step-by-step" lasing technique was applied whereby the tip of the emitting laser catheter is advanced ahead of a guide wire that serves mainly as support for positioning of that catheter. Adequate penetration of the atretic tissue enabled introduction of balloon dilations resulting in patency of the atretic valve, decompression of the right ventricle, improved right and left ventricular hemodynamics, and oxygenation. To further investigate the effect of excimer laser energy on atretic valvular tissue this laser was applied in a specimen of heart from an infant who died because of PA/IVS. Histopathologic examination of the irradiated tissue revealed no laser-induced injury to the pulmonary valve. Thus, laser ablation and penetration of an atretic pulmonary valve is feasible and safe. The penetration of the atretic valve with the laser catheter enables subsequent introduction of various sizes balloon dilations. The application of available laser sources for treatment of congenital heart diseases is reviewed. JF - Lasers in Surgery and Medicine AU - Moskowitz, William B AU - Titus, Jack L AU - Topaz, On AD - Interventional Cardiology, McGuire Veterans Affairs Medical Center, Division of Cardiology, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA, USA, on.topaz@med.va.gov Y1 - 2004/12// PY - 2004 DA - Dec 2004 SP - 327 EP - 335 PB - John Wiley & Sons, Ltd. VL - 35 IS - 5 SN - 0196-8092, 0196-8092 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Hemodynamics KW - Balloons KW - Ventricle KW - U.V. radiation KW - Lung KW - Reviews KW - Energy KW - Catheters KW - Lasers KW - Septum KW - Heart diseases KW - Infants KW - W4 130:General Biomedical Engineering: Tools & Techniques KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17391963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lasers+in+Surgery+and+Medicine&rft.atitle=Excimer+laser+ablation+for+valvular+angioplasty+in+pulmonary+atresia+and+intact+ventricular+septum&rft.au=Moskowitz%2C+William+B%3BTitus%2C+Jack+L%3BTopaz%2C+On&rft.aulast=Moskowitz&rft.aufirst=William&rft.date=2004-12-01&rft.volume=35&rft.issue=5&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Lasers+in+Surgery+and+Medicine&rft.issn=01968092&rft_id=info:doi/10.1002%2Flsm.20106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lasers; Lung; Catheters; Infants; Energy; Ventricle; Balloons; Hemodynamics; Septum; U.V. radiation; Heart diseases; Reviews DO - http://dx.doi.org/10.1002/lsm.20106 ER - TY - JOUR T1 - Continuous ethanol exposure inhibits agonist-stimulated phosphorylation of p70S6 kinase and ribosomal S6 protein in cultured rat astrocytes AN - 17609446; 6158030 AB - The effects of ethanol exposure on agonist-stimulated phosphorylation of p70S6 kinase and ribosomal S6 protein were determined in confluent astrocyte monolayers. Basal phosphorylation of p70S6 kinase and S6 protein was either unaffected or reduced, respectively, after exposure to 50 mM ethanol for 4 days. The abilities of norepinephrine, carbachol and epidermal growth factor to phosphorylate these proteins were significantly decreased after ethanol exposure. In contrast, ethanol exposure had no effect on the protein expression of either p70S6 kinase or S6 protein. Our data suggest that continuous ethanol exposure results in a generalized decrease in agonist-activation of the p70S6 pathway. and receptors JF - Molecular Brain Research AU - Smith, T L AU - Eaton, M C AD - Research Health Care Group (0-151), Southern Arizona VA Health Care System, Tucson, AZ, USA, thomas.smith6@med.va.gov Y1 - 2004/11/24/ PY - 2004 DA - 2004 Nov 24 SP - 145 EP - 148 VL - 131 IS - 1-2 SN - 0169-328X, 0169-328X KW - rats KW - Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts; Toxicology Abstracts KW - N 14070:Ribosomes: rRNA, ribosomal proteins, and translation KW - N3 11106:Neurobiology of drug abuse KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17609446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Brain+Research&rft.atitle=Continuous+ethanol+exposure+inhibits+agonist-stimulated+phosphorylation+of+p70S6+kinase+and+ribosomal+S6+protein+in+cultured+rat+astrocytes&rft.au=Smith%2C+T+L%3BEaton%2C+M+C&rft.aulast=Smith&rft.aufirst=T&rft.date=2004-11-24&rft.volume=131&rft.issue=1-2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Molecular+Brain+Research&rft.issn=0169328X&rft_id=info:doi/10.1016%2Fj.molbrainres.2004.08.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-04-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1016/j.molbrainres.2004.08.018 ER - TY - JOUR T1 - Incidence of thyroid dysfunction during interferon alfa-2b and ribavirin therapy in men with chronic hepatitis C: a prospective cohort study. AN - 67097279; 15557418 AB - Thyroid dysfunction is a known complication of interferon monotherapy in women with hepatitis C virus (HCV) infection. The aims of this study were to determine the incidence and long-term outcome of thyroid dysfunction in HCV-infected men receiving interferon and ribavirin combination therapy. We prospectively studied 225 HCV-infected men with baseline levels of thyrotropin (TSH) within the reference range who were treated with subcutaneous interferon alfa-2b (3 million units 3 times per week) and oral ribavirin (1000-1200 mg/d) for 24 to 48 weeks. Patients underwent screening of TSH levels every 12 weeks during HCV therapy and at weeks 12 and 24 after completion of treatment. Patients with abnormal TSH levels underwent a comprehensive thyroid evaluation. Among the 225 patients, overt thyroid disease developed in 6.7% (95% confidence interval, 3.8%-10.8%), and subclinical thyroid disease was diagnosed in 4.0% (95% confidence interval, 1.8%-7.4%). In the 12 patients with overt hypothyroidism, antithyroglobulin antibodies were present in 11 and antithyroid peroxidase antibodies were present in 10, whereas thyroid-stimulating immunoglobulins were present in 2 of the 3 individuals with overt hyperthyroidism. Most of the patients with thyroid dysfunction completed HCV therapy, and thyroid disease resolved in 10 of the 12 patients with overt hypothyroidism, 2 of the 3 with overt hyperthyroidism, and all 9 with subclinical thyroid disease. Men with HCV infection treated with interferon and ribavirin should undergo routine screening for thyroid disease. Treatment of HCV can be safely continued in these patients because thyroid disease responds well to treatment and is reversible in most individuals. JF - Archives of internal medicine AU - Bini, Edmund J AU - Mehandru, Saurabh AD - Department of Medicine and Division of Gastroenterology, Veterans Affairs New York Harbor Healthcare System, New York 10010, USA. Edmund.Bini@med.va.gov Y1 - 2004/11/22/ PY - 2004 DA - 2004 Nov 22 SP - 2371 EP - 2376 VL - 164 IS - 21 SN - 0003-9926, 0003-9926 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - Recombinant Proteins KW - interferon alfa-2b KW - 43K1W2T1M6 KW - Ribavirin KW - 49717AWG6K KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Prospective Studies KW - Sex Factors KW - Humans KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Antiviral Agents -- therapeutic use KW - Antiviral Agents -- administration & dosage KW - Interferon-alpha -- therapeutic use KW - Ribavirin -- therapeutic use KW - Interferon-alpha -- administration & dosage KW - Hepatitis C, Chronic -- drug therapy KW - Thyroid Diseases -- diagnosis KW - Ribavirin -- adverse effects KW - Thyroid Diseases -- chemically induced KW - Thyroid Diseases -- therapy KW - Interferon-alpha -- adverse effects KW - Hepatitis C, Chronic -- complications KW - Ribavirin -- administration & dosage KW - Antiviral Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67097279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Incidence+of+thyroid+dysfunction+during+interferon+alfa-2b+and+ribavirin+therapy+in+men+with+chronic+hepatitis+C%3A+a+prospective+cohort+study.&rft.au=Bini%2C+Edmund+J%3BMehandru%2C+Saurabh&rft.aulast=Bini&rft.aufirst=Edmund&rft.date=2004-11-22&rft.volume=164&rft.issue=21&rft.spage=2371&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-23 N1 - Date created - 2004-11-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 2005 May 9;165(9):1072; author reply 1072-3 [15883255] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterizations of long-term oxycodone/acetaminophen prescriptions in veteran patients. AN - 67096519; 15557416 AB - Long-term management of chronic pain with opioids may be stable over time or may be complicated by problematic dose increases, drug dependencies, and toxic effects. To determine clinical contexts in which stability or problems may occur, we examined the pharmacologic and clinical correlates of long-term prescriptions of oxycodone/acetaminophen, a commonly prescribed short-acting opioid formulation. We analyzed linked, archival outpatient pharmacy and clinical databases from the New England Veterans Integrated Service Network between January 1, 1998, and June 30, 2001. Durations, doses, and dose changes of oxycodone/acetaminophen prescriptions and concurrent use of long-acting opioids, benzodiazepines, tricyclic antidepressants, and anticonvulsants were determined. In aggregate, 2195 patients (31% with cancer diagnoses per the International Classification of Diseases, Ninth Revision, Clinical Modification) received oxycodone/acetaminophen for more than 9 months at a mean prescribed daily dose of 3.9 tablets per day (range, 0.5-13.0 tablets per day) with minimal changes in daily prescribed mean dose over time. Patients with cancer were more likely than other patients to receive concurrent long-acting opioids. For patients without cancer, a higher mean daily dose was associated with duration, older age, human immunodeficiency virus (HIV) and/or AIDS, and with prescribed benzodiazepines and long-acting opioids; concurrent benzodiazepine prescriptions were associated with anticonvulsant prescriptions and with psychogenic pain and alcohol abuse and/or dependence diagnoses. In veteran patients who received long-term oxycodone/acetaminophen prescriptions, mean daily doses were typically modest and stable, likely reflecting a selection of patients with successful, long-term management. Among patients without cancer, however, associations of higher oxycodone/acetaminophen doses with benzodiazepine prescriptions, psychogenic pain, alcohol abuse, and HIV/AIDS may portend opioid prescription management problems. JF - Archives of internal medicine AU - Hermos, John A AU - Young, Melissa M AU - Gagnon, David R AU - Fiore, Louis D AD - The Pharmacoepidemiology Research Group, Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston 02130, USA. john.hermos@med.va.gov Y1 - 2004/11/22/ PY - 2004 DA - 2004 Nov 22 SP - 2361 EP - 2366 VL - 164 IS - 21 SN - 0003-9926, 0003-9926 KW - Analgesics, Non-Narcotic KW - 0 KW - Analgesics, Opioid KW - Drug Combinations KW - Acetaminophen KW - 362O9ITL9D KW - Oxycodone KW - CD35PMG570 KW - Abridged Index Medicus KW - Index Medicus KW - Pain -- etiology KW - Pain -- drug therapy KW - Neoplasms -- complications KW - Humans KW - Adult KW - Chronic Disease KW - Time Factors KW - Male KW - Female KW - Veterans KW - Acetaminophen -- administration & dosage KW - Oxycodone -- administration & dosage KW - Analgesics, Opioid -- administration & dosage KW - Analgesics, Non-Narcotic -- administration & dosage KW - Drug Prescriptions -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67096519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Characterizations+of+long-term+oxycodone%2Facetaminophen+prescriptions+in+veteran+patients.&rft.au=Hermos%2C+John+A%3BYoung%2C+Melissa+M%3BGagnon%2C+David+R%3BFiore%2C+Louis+D&rft.aulast=Hermos&rft.aufirst=John&rft.date=2004-11-22&rft.volume=164&rft.issue=21&rft.spage=2361&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-23 N1 - Date created - 2004-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Addiction Severity Index medical and psychiatric composite scores measure similar domains as the SF-36 in substance-dependent veterans: concurrent and discriminant validity. AN - 66979282; 15488340 AB - Recently attention has focused on the assessment of functional health status in substance-dependent individuals. The addiction severity index (ASI) is a widely used assessment instrument that includes scales to reflect current medical and psychiatric status. This study examines the concurrent validity of these ASI composite scores in relation to the short form 36-item health survey (SF-36), a well-established measure of health-related quality of life/functional health status. Veterans (n=674) were assessed at admission to substance dependence treatment. Correlations were performed between ASI composite scores and SF-36 scales and the physical and mental summary components (PSC and MSC, respectively). Areas under receiver operating characteristic (ROC) curves determined the descriminative ability of the ASI composites to ascertain impairment. The ASI medical composite score demonstrated robust correlations with the four SF-36 scales that relate to physical health and with the PCS. The ASI psychiatric composite score had robust correlations with the four SF-36 scales related to mental health and with the mental component summary (MCS). ROC curves indicated that the ASI medical (AUC=0.83) and psychiatric composites (AUC=0.90) accurately detected subjects with impairment. ASI medical and psychiatric composite scores provide effective initial screening for patients with impaired functional status as measured by the corresponding SF-36 component summary scores. JF - Drug and alcohol dependence AU - Calsyn, Donald A AU - Saxon, Andrew J AU - Bush, Kristen R AU - Howell, Donelle N AU - Baer, John S AU - Sloan, Kevin L AU - Malte, Carol A AU - Kivlahan, Daniel R AD - VA Puget Sound Health Care System, Center of Excellence in Substance Abuse Treatment and Education, 1660 S Columbian Way, Seattle, WA 98108, USA. donald.calsyn@med.va.gov Y1 - 2004/11/11/ PY - 2004 DA - 2004 Nov 11 SP - 165 EP - 171 VL - 76 IS - 2 SN - 0376-8716, 0376-8716 KW - Index Medicus KW - Reproducibility of Results KW - Humans KW - Activities of Daily Living -- psychology KW - Referral and Consultation KW - Aged KW - Psychometrics -- statistics & numerical data KW - Primary Health Care KW - Quality of Life -- psychology KW - Comorbidity KW - Health Status Indicators KW - Substance Abuse Treatment Centers KW - Adult KW - Health Surveys KW - Treatment Outcome KW - Patient Admission -- statistics & numerical data KW - Activities of Daily Living -- classification KW - Middle Aged KW - Delivery of Health Care, Integrated KW - Female KW - Male KW - Alcoholism -- rehabilitation KW - Mental Disorders -- rehabilitation KW - Alcoholism -- epidemiology KW - Personality Assessment -- statistics & numerical data KW - Mental Disorders -- epidemiology KW - Veterans -- psychology KW - Mental Disorders -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66979282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=The+Addiction+Severity+Index+medical+and+psychiatric+composite+scores+measure+similar+domains+as+the+SF-36+in+substance-dependent+veterans%3A+concurrent+and+discriminant+validity.&rft.au=Calsyn%2C+Donald+A%3BSaxon%2C+Andrew+J%3BBush%2C+Kristen+R%3BHowell%2C+Donelle+N%3BBaer%2C+John+S%3BSloan%2C+Kevin+L%3BMalte%2C+Carol+A%3BKivlahan%2C+Daniel+R&rft.aulast=Calsyn&rft.aufirst=Donald&rft.date=2004-11-11&rft.volume=76&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-03-01 N1 - Date created - 2004-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A randomized trial of nortriptyline combined with transdermal nicotine for smoking cessation. AN - 67060584; 15534159 AB - Smoking cessation rates with current therapy are suboptimal. Tricyclic antidepressants improve cessation rates. We hypothesized that addition of nortriptyline hydrochloride to transdermal nicotine would enhance cessation rates. We conducted a randomized, double-blind, placebo-controlled trial at a Department of Veterans Affairs medical center. Subjects were aged 18 to 65 years, smoked 10 or more cigarettes per day, and did not have current major depression. Nortriptyline hydrochloride or matched placebo was started at 25 mg 14 days before quit day, titrated to 75 mg/d as tolerated, and continued for 12 weeks after quit day. Transdermal nicotine (21 mg/d) was started on quit day and continued for 8 weeks. The behavioral intervention consisted of 12 brief, individual visits. Withdrawal symptoms were measured by means of a daily diary, and smoking cessation was defined as self-reported abstinence, expired carbon monoxide level of 9 ppm or less, and a 6-month urine cotinine level less than 50 ng/mL (284 nmol/L). A total of 158 patients were randomized (79 to nortriptyline and 79 to placebo). There was no significant reduction in withdrawal symptoms. The cessation rates at 6 months were 23% (18/79) and 10% (8/79), respectively (absolute difference, 13%; 95% confidence interval, 1.3%-24.5%; P = .052). Nortriptyline caused frequent side effects, including dry mouth (38%) and sedation (20%). Nortriptyline combined with transdermal nicotine resulted in an increased cessation rate with little effect on withdrawal symptoms. This combination may represent an option for smokers in whom standard therapy has failed. JF - Archives of internal medicine AU - Prochazka, Allan V AU - Kick, Steven AU - Steinbrunn, Connie AU - Miyoshi, Thomas AU - Fryer, George E AD - Division of General Internal Medicine, University of Colorado Health Sciences Center, Denver, USA. Allan.Prochazka@med.va.gov Y1 - 2004/11/08/ PY - 2004 DA - 2004 Nov 08 SP - 2229 EP - 2233 VL - 164 IS - 20 SN - 0003-9926, 0003-9926 KW - Nicotine KW - 6M3C89ZY6R KW - Nortriptyline KW - BL03SY4LXB KW - Abridged Index Medicus KW - Index Medicus KW - Administration, Oral KW - Probability KW - Reference Values KW - Administration, Cutaneous KW - Drug Administration Schedule KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Humans KW - Smoking -- adverse effects KW - Aged KW - Risk Assessment KW - Drug Therapy, Combination KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Adolescent KW - Statistics, Nonparametric KW - Male KW - Female KW - Substance Withdrawal Syndrome -- diagnosis KW - Substance Withdrawal Syndrome -- epidemiology KW - Smoking Cessation -- methods KW - Nicotine -- administration & dosage KW - Nortriptyline -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67060584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=A+randomized+trial+of+nortriptyline+combined+with+transdermal+nicotine+for+smoking+cessation.&rft.au=Prochazka%2C+Allan+V%3BKick%2C+Steven%3BSteinbrunn%2C+Connie%3BMiyoshi%2C+Thomas%3BFryer%2C+George+E&rft.aulast=Prochazka&rft.aufirst=Allan&rft.date=2004-11-08&rft.volume=164&rft.issue=20&rft.spage=2229&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-02 N1 - Date created - 2004-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drop-in, drop-out allele-specific PCR. A highly sensitive, single-tube method AN - 954577896; 13860100 AB - Allelotyping large numbers of samples by allele-specific polymerase chain reaction (PCR) can be problematic if the DNA samples to be tested are of highly variable concentration. On the one hand, analysis of dilute DNA samples often requires nested PCR to produce a product of sufficient yield to be detectable on ethidium bromide-stained agarose gels. Such two-step assays require additional reagents, are labor-intensive, and have a higher risk of contaiminations. On the other hand, the specificity of allele-specific PCR assays can be lost at high input DNA concentrations. Large population-based genetic studies using DNA from varied sources would benefit from one-tube assays that could detect mutations in samples over a wide range of concentration. We describe a one-tube nested allele-specific PCR-based assay, in which the input DNA concentration has little effect on the assay's yield or specificity. An assay using this method is highly sensitive and specific, and was used to type several thousand DNA samples, obtained from various sources, for a G to A transition at human transthyretin codon 122. Similar assays could be readily adapted to any high-throughput allelotype assay where input DNA is of highly variable concentration. JF - Molecular Biotechnology AU - Alexander, Alice AU - Subramanian, Nivedita AU - Buxbaum, Joel N AU - Jacobson, Daniel R AD - Department of Veterans Affairs, Research Service 151, New York Campus, New York Harbor Healthcare System, 423 East 23 Street, 10010, New York, NY, USA, daniel.jacobson@med.va.gov Y1 - 2004/11// PY - 2004 DA - Nov 2004 SP - 171 EP - 174 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 28 IS - 3 SN - 1073-6085, 1073-6085 KW - Biotechnology and Bioengineering Abstracts KW - Gels KW - transthyretin KW - Risk factors KW - Codons KW - Polymerase chain reaction KW - Mutation KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954577896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Biotechnology&rft.atitle=Drop-in%2C+drop-out+allele-specific+PCR.+A+highly+sensitive%2C+single-tube+method&rft.au=Alexander%2C+Alice%3BSubramanian%2C+Nivedita%3BBuxbaum%2C+Joel+N%3BJacobson%2C+Daniel+R&rft.aulast=Alexander&rft.aufirst=Alice&rft.date=2004-11-01&rft.volume=28&rft.issue=3&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Molecular+Biotechnology&rft.issn=10736085&rft_id=info:doi/10.1385%2FMB%3A28%3A3%3A171 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Gels; transthyretin; Risk factors; Codons; Polymerase chain reaction; Mutation DO - http://dx.doi.org/10.1385/MB:28:3:171 ER - TY - JOUR T1 - Cost of chronic hepatitis B infection in the United States. AN - 85413640; pmid-15602162 AB - To estimate the direct medical costs associated with chronic hepatitis B (CHB) infection in the United States.Approximately 240,000 new cases of hepatitis B infection occur annually in the United States. There are estimated to be 1.25 million sufferers of CHB in the United States. However, the economic impact of these infections has not been well studied.We conducted a retrospective cohort analysis using administrative healthcare claims data to estimate costs for six health states associated with CHB infection. The six states were as follows: 1) CHB, 2) compensated cirrhosis, 3) decompensated cirrhosis, 4) liver transplantation, 5) transplant care >12 months following transplant, and 6) hepatocellular carcinoma. Patients in each health state were identified using diagnostic and procedure codes, and their utilization was tracked during their time in that health state. To estimate costs, we used reimbursed amounts and adjusted to year US 2000 dollars.Average annual costs for patients in each health state were as follows: CHB, US 761 dollars; compensated cirrhosis, US 227 dollars; decompensated cirrhosis, US 11,459 dollars; liver transplant, US 86,552 dollars; transplant care >12 months following transplant, US 12,560 dollars; and hepatocellular carcinoma, US 7,533 dollars. Medications contributed the largest proportion of costs in CHB and compensated cirrhosis disease states, while hospitalizations were the largest cost component in the other health states.This analysis provides estimates of the annual costs of complications of hepatitis B infection in the United States. The most progressive health states were associated with significantly higher costs. JF - Journal of clinical gastroenterology AU - Lee, Todd A AU - Veenstra, David L AU - Iloeje, Uchenna H AU - Sullivan, Sean D AD - Midwest Center for Health Services and Policy Research, Hines VA Hospital, Hines, IL, USA. lee@research.hines.med.va.gov Y1 - 2004/11// PY - 2004 DA - Nov 2004 SP - S144 EP - S147 VL - 38 IS - 10 Suppl 3 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Cohort Studies KW - Costs and Cost Analysis KW - *Health Care Costs KW - *Hepatitis B, Chronic: economics KW - Humans KW - Middle Aged KW - Retrospective Studies KW - United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85413640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Cost+of+chronic+hepatitis+B+infection+in+the+United+States.&rft.au=Lee%2C+Todd+A%3BVeenstra%2C+David+L%3BIloeje%2C+Uchenna+H%3BSullivan%2C+Sean+D&rft.aulast=Lee&rft.aufirst=Todd&rft.date=2004-11-01&rft.volume=38&rft.issue=10+Suppl+3&rft.spage=S144&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Effects of gender on neurologic and functional recovery after spinal cord injury. AN - 85303993; pmid-15520978 AB - OBJECTIVE: To assess gender differences in neurologic and functional outcome measures in persons with spinal cord injury (SCI). DESIGN: Case series. SETTINGS: Model Spinal Cord Injury Systems (MSCIS) throughout the United States. PARTICIPANTS: People (N=14,433) admitted to an MSCIS within 30 days of injury. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Improvement in American Spinal Injury Association (ASIA) motor index score, ASIA Impairment Scale, level of injury, and FIM instrument scores after SCI. RESULTS: When examining subjects grouped by severity of injury, changes in ASIA motor index total scores, from system admission to 1-year anniversary, were significantly greater for women than men with either complete ( P =.035) or incomplete ( P =.031) injuries. Functional comparison of men and women, using the FIM motor subscale, revealed that men had higher FIM motor scores at rehabilitation discharge among those with motor-complete injuries, except for those with C1-4 and C6 neurologic levels. Women with motor-incomplete high tetraplegia (C1-4 levels) had higher discharge FIM motor scores than did similarly afflicted men. There were no significant differences in FIM motor scores among men and women with other levels of motor incomplete SCI. CONCLUSIONS: Gender differences in SCI were seen in several areas. Women may have more natural neurologic recovery than men; however, for a given level and degree of neurologic injury, men tend to do better functionally than women at time of discharge from rehabilitation. Future prospective study of the effects of estrogen on neurologic recovery and the effects of gender on functional potential are recommended. JF - Archives of Physical Medicine and Rehabilitation AU - Sipski, Marca L AU - Jackson, Amie B AU - Gómez-Marín Orlando AU - Estores Irene AU - Stein, Adam AD - Center for Excellence in Functional Recovery in Chronic SCI, Veterans Administration Rehabilitation Research and Development, Miami, FL, USA. PY - 2004 SP - 1826 EP - 1836 VL - 85 IS - 11 SN - 0003-9993, 0003-9993 KW - United States KW - Sex Characteristics KW - Humans KW - Aged KW - Child KW - Infant KW - Spinal Cord Injuries KW - Comparative Study KW - Aged, 80 and over KW - Research Support, U.S. Gov't, Non-P.H.S. KW - Adult KW - Treatment Outcome KW - Adolescent KW - Trauma Severity Indices KW - Male KW - Estrogens KW - Sex Factors KW - Infant, Newborn KW - Motor Skills KW - Child, Preschool KW - Length of Stay KW - Logistic Models KW - Disability Evaluation KW - Middle Aged KW - Menopause KW - Female KW - Men KW - Women KW - Activities of Daily Living KW - Recovery of Function UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85303993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Effects+of+gender+on+neurologic+and+functional+recovery+after+spinal+cord+injury.&rft.au=Sipski%2C+Marca+L%3BJackson%2C+Amie+B%3BG%C3%B3mez-Mar%C3%ADn+Orlando%3BEstores+Irene%3BStein%2C+Adam&rft.aulast=Sipski&rft.aufirst=Marca&rft.date=2004-11-01&rft.volume=85&rft.issue=11&rft.spage=1826&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - A randomized trial of concurrent versus delayed smoking intervention for patients in alcohol dependence treatment. AN - 67244645; 15700504 AB - Fear of jeopardizing drinking outcomes has resulted in a reluctance to treat tobacco dependence concurrently with alcohol dependence, in spite of the high prevalence of smoking among patients with alcohol dependence. The objective of this study was to compare the effects of smoking treatment and intensive treatment for alcohol dependence, delivered concurrently, with delayed smoking treatment on smoking and alcohol use. For the study, 1,943 patients in intensive treatment for alcohol dependence or abuse were screened for participation. Of these, 499 smokers were enrolled and randomized to concurrent (during alcohol treatment) or delayed (6 months later) smoking intervention. The smoking intervention included individual behavioral counseling and nicotine replacement. The main smoking outcome measure was 7-day point prevalent tobacco abstinence, and the main drinking outcome was 6-month prolonged abstinence from alcohol; both measured 18 months after study enrollment. Participants in the concurrent group were more likely to participate in smoking treatment than those in the delayed group (78.5% vs 64.5%, p = .005), but there was no significant difference in cessation rates at 18 months (12.4% vs 13.7%). Prolonged, 6-month abstinence from alcohol was worse in the concurrent group than in the delayed group at 6, 12 and 18 months (41% vs 56%, p =.001; 33% vs 42%,p = .06; 41% vs 48%, p = .14, respectively), and 30-day prolonged alcohol abstinence was also worse in the concurrent treatment group (51% vs 64%, p = .004; 46% vs 53%, p = .11; 48% vs 60%, p = .01, respectively). These data show that patients in alcohol treatment are interested in smoking cessation, participate in treatment and demonstrate success; but there was no benefit of concurrent treatment. Drinking outcomes were worse with concurrent tobacco treatment. These findings suggest that smoking cessation intervention should be provided to patients after intensive alcohol treatment; however, the data require confirmation because they are not consistent with the existing literature. JF - Journal of studies on alcohol AU - Joseph, Anne M AU - Willenbring, Mark L AU - Nugent, Sean M AU - Nelson, David B AD - Center for Chronic Disease Outcomes Research, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA. Anne.M.Joseph@med.va.gov Y1 - 2004/11// PY - 2004 DA - November 2004 SP - 681 EP - 691 VL - 65 IS - 6 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Humans KW - Adult KW - Temperance -- psychology KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Time Factors KW - Temperance -- statistics & numerical data KW - Male KW - Female KW - Smoking -- therapy KW - Substance Abuse Treatment Centers -- statistics & numerical data KW - Smoking Cessation -- psychology KW - Substance Abuse Treatment Centers -- methods KW - Alcoholism -- therapy KW - Smoking Cessation -- methods KW - Smoking -- psychology KW - Alcoholism -- psychology KW - Smoking Cessation -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67244645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=A+randomized+trial+of+concurrent+versus+delayed+smoking+intervention+for+patients+in+alcohol+dependence+treatment.&rft.au=Joseph%2C+Anne+M%3BWillenbring%2C+Mark+L%3BNugent%2C+Sean+M%3BNelson%2C+David+B&rft.aulast=Joseph&rft.aufirst=Anne&rft.date=2004-11-01&rft.volume=65&rft.issue=6&rft.spage=681&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-25 N1 - Date created - 2005-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Potential benefits of quetiapine in the treatment of substance dependence disorders. AN - 67228651; 15644986 AB - Some antipsychotic medications prescribed for the treatment of psychoses, mood disorders or post-traumatic stress disorder in patients with coexisting substance dependence disorders (SDD) have reduced substance dependence. We studied the potential benefits of quetiapine in the treatment of SDD. We conducted a retrospective chart review of data for 9 patients who were admitted to a 28-day residential rehabilitation program designed for individuals with SDD during a 3-month period from January 2003 through March 2003 and treated with quetiapine for nonpsychotic anxiety. These patients also met the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, criteria for alcohol, cocaine and/or methamphetamine dependence and substance-induced anxiety disorder. The patients were assessed using the Hamilton-D Rating Scale for Depression (Ham-D), a 10-point Likert scale to measure alcohol or drug cravings, and random Breathalyzer and urine drug screens. Quetiapine was generally well tolerated. Only 1 of the 9 patients stopped taking the medication because of increased anxiety. Other patients reported improvement in sleep and anxiety. The mean decrease in Ham-D score at discharge for the responders was 18.5 (p < 0.005). The biggest decreases on the Ham-D occurred on the subscales of insomnia, agitation, somatic anxiety, psychologic anxiety, hypochondriasis and obsessional symptoms. The mean decrease in the Likert 10-point craving scale was 5.9 for the responders (p < 0.005). These patients' periodic Breathalyzer and urine test results suggested that they remained abstinent from alcohol and other drug use. Quetiapine was beneficial in the treatment of SDD in patients with nonpsychotic anxiety. JF - Journal of psychiatry & neuroscience : JPN AU - Sattar, S Pirzada AU - Bhatia, Subhash C AU - Petty, Frederick AD - Department of Psychiatry, Creighton University School of Medicine and Omaha VA Medical Center, Omaha, NE 68131, USA. syed.sattar@med.va.gov Y1 - 2004/11// PY - 2004 DA - November 2004 SP - 452 EP - 457 VL - 29 IS - 6 SN - 1180-4882, 1180-4882 KW - Anti-Anxiety Agents KW - 0 KW - Antidepressive Agents KW - Antipsychotic Agents KW - Dibenzothiazepines KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Patient Admission KW - Humans KW - Retrospective Studies KW - Anti-Anxiety Agents -- therapeutic use KW - Anxiety Disorders -- rehabilitation KW - Antidepressive Agents -- adverse effects KW - Comorbidity KW - Drug Therapy, Combination KW - Substance Abuse Treatment Centers KW - Substance Abuse Detection KW - Adult KW - Treatment Outcome KW - Anti-Anxiety Agents -- adverse effects KW - Antidepressive Agents -- therapeutic use KW - Middle Aged KW - Anxiety Disorders -- chemically induced KW - Nebraska KW - Female KW - Male KW - Alcoholism -- rehabilitation KW - Dibenzothiazepines -- adverse effects KW - Antipsychotic Agents -- therapeutic use KW - Amphetamine-Related Disorders -- rehabilitation KW - Antipsychotic Agents -- adverse effects KW - Cocaine-Related Disorders -- rehabilitation KW - Dibenzothiazepines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67228651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychiatry+%26+neuroscience+%3A+JPN&rft.atitle=Potential+benefits+of+quetiapine+in+the+treatment+of+substance+dependence+disorders.&rft.au=Sattar%2C+S+Pirzada%3BBhatia%2C+Subhash+C%3BPetty%2C+Frederick&rft.aulast=Sattar&rft.aufirst=S&rft.date=2004-11-01&rft.volume=29&rft.issue=6&rft.spage=452&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychiatry+%26+neuroscience+%3A+JPN&rft.issn=11804882&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-02-23 N1 - Date created - 2005-01-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Psychopharmacol. 2000 Feb;20(1):94-8 [10653215] J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62 [14399272] Schizophr Bull. 2000;26(2):441-9 [10885642] Eur Neuropsychopharmacol. 2000 Sep;10(5):325-32 [10974602] J Psychoactive Drugs. 2000 Nov;32 Suppl:i-iv, 1-112 [11280926] Actas Esp Psiquiatr. 2001 Mar-Apr;29(2):124-30 [11333531] J Subst Abuse Treat. 2001 Dec;21(4):217-21 [11777671] Ann Pharmacother. 2002 Dec;36(12):1875-8 [12452747] Int J Psychiatry Med. 2003;33(1):85-9 [12906345] J Clin Psychopharmacol. 2004 Feb;24(1):101-2 [14709960] J Clin Psychopharmacol. 2004 Oct;24(5):532-5 [15349010] Acta Psychiatr Scand Suppl. 1966;192:193-6 [5227583] Arch Gen Psychiatry. 1973 Aug;29(2):218-25 [4741512] Int Pharmacopsychiatry. 1973;8(4):248-51 [4589641] Int J Clin Pharmacol. 1974 Jun;9(4):321-5 [4609289] J Nerv Ment Dis. 1975 Feb;160(2-1):83-99 [235010] Hosp Community Psychiatry. 1975 Sep;26(9):574 [238907] Int J Clin Pharmacol Biopharm. 1978 Jul;16(7):331-2 [352974] Mil Med. 1979 Apr;144(4):251-2 [108622] Acta Psychiatr Belg. 1981 Mar-Apr;81(2):121-7 [7293809] Am J Psychiatry. 1985 Nov;142(11):1259-64 [3904487] Arch Gen Psychiatry. 1989 Apr;46(4):322-5 [2930329] Schizophr Bull. 1990;16(1):111-22 [1970669] Schizophr Bull. 1990;16(1):81-5 [1970670] EXS. 1994;71:361-70 [8032167] Psychopharmacology (Berl). 1995 May;119(1):124-6 [7675943] Psychopharmacol Bull. 1997;33(1):177-81 [9133772] Schizophr Bull. 1997;23(2):215-28 [9165632] J Psychoactive Drugs. 1997 Jul-Sep;29(3):249-54 [9339856] J Subst Abuse Treat. 1998 Mar-Apr;15(2):113-6 [9561949] J Clin Psychiatry. 1998;59 Suppl 12:46-52 [9766620] Am J Addict. 1999 Spring;8(2):120-7 [10365192] Harv Rev Psychiatry. 1999 Mar-Apr;6(6):287-96 [10370435] J Clin Psychiatry. 1999;60 Suppl 12:43-6 [10372611] Am J Psychiatry. 1999 Jul;156(7):1119-20 [10401473] Arch Gen Psychiatry. 2000 Jun;57(6):553-9 [10839333] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Predicting methadone maintenance treatment outcomes using the Addiction Severity Index and the MMPI-2 Content Scales (Negative Treatment Indicators and Cynism scales). AN - 67222983; 15624551 AB - We studied the ability of the Minnesota Multiphasic Personality Inventory-2 Content Scales (Negative Treatment Indicators [TRT] and Cynicism [CYN]) and the domain scales of the Addiction Severity Index (ASI) in predicting outcome from a methadone maintenance program. Participants were 108 African American males treated in a VA health care outpatient methadone maintenance treatment program and followed for up to 1 year after admission. Dependent variables were 1) length of stay and the percentage of 2) missed medication days, 3) toxicology urine samples free from illicit drugs, 4) full-time employment, 5) attendance at scheduled counseling sessions, and 6) counselor ratings of patient progress. A stepwise linear regression equation indicated that low drug severity scores on the ASI and low scores on percentage of missed medication predicted patients who were clean 1 year later; low scores on the psychological domain of the ASI predicted attendance at counseling sessions; a discriminant function analysis (consisting of percent of missed medication, percentage of clean urines, and ratings of patient progress) successfully predicted patient status (i.e., dropouts vs. "active patients") with 85% accuracy. Although the TRT and CYN were related to some ASI domains, they were not associated with any outcome variable. Results suggest that some ASI scores serve as important indicators of patient progress in methadone maintenance treatment. JF - The American journal of drug and alcohol abuse AU - Craig, Robert J AU - Olson, Ronald E AD - Drug Abuse Treatment Center, VA Chicago Health Care System, 820 South Damen Ave., Chicago, IL 60612-3740, USA. Robert.Craig2@med.va.gov Y1 - 2004/11// PY - 2004 DA - November 2004 SP - 823 EP - 839 VL - 30 IS - 4 SN - 0095-2990, 0095-2990 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Reproducibility of Results KW - Combined Modality Therapy KW - Humans KW - European Continental Ancestry Group -- psychology KW - Adult KW - Prognosis KW - Patient Dropouts -- statistics & numerical data KW - Patient Dropouts -- psychology KW - Middle Aged KW - Hispanic Americans -- psychology KW - Psychometrics KW - Male KW - Social Perception KW - Methadone -- therapeutic use KW - Opioid-Related Disorders -- psychology KW - Personality Inventory -- statistics & numerical data KW - Patient Acceptance of Health Care KW - MMPI -- statistics & numerical data KW - Opioid-Related Disorders -- rehabilitation KW - African Continental Ancestry Group -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67222983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Predicting+methadone+maintenance+treatment+outcomes+using+the+Addiction+Severity+Index+and+the+MMPI-2+Content+Scales+%28Negative+Treatment+Indicators+and+Cynism+scales%29.&rft.au=Craig%2C+Robert+J%3BOlson%2C+Ronald+E&rft.aulast=Craig&rft.aufirst=Robert&rft.date=2004-11-01&rft.volume=30&rft.issue=4&rft.spage=823&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-22 N1 - Date created - 2004-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fluoxetine attenuates adrenocortical but not subjective responses to cocaine cues. AN - 67209042; 15624548 AB - Preclinical data suggest a link between stress reactivity and cocaine self-administration by rodents. Serotonin appears to modulate the hypothalamic-pituitary-adrenal (HPA) axis. We studied the effects of chronic treatment with the serotonin reuptake inhibitor fluoxetine 40 mg/day on subjective and hormonal responses to cocaine cues in 22 subjects participating in a controlled clinical trial for cocaine dependence. Fluoxetine antagonized the cue-induced increase in cortisol but increased subjects' ratings of the likelihood of cocaine use in response to cocaine cues. Cortisol response to cocaine cues was not related to subjective craving. Activation of the HPA axis by cocaine cues does not appear to be a necessary mediator of cue-induced craving. JF - The American journal of drug and alcohol abuse AU - Harris, Debra S AU - Batki, Steven L AU - Berger, S Paul AD - Department of Psychiatry, University of Cincinnati and Cincinnati VA Medical Center, Cincinnati, Ohio 45220, USA. debra.harris4@med.va.gov Y1 - 2004/11// PY - 2004 DA - November 2004 SP - 765 EP - 782 VL - 30 IS - 4 SN - 0095-2990, 0095-2990 KW - Serotonin Uptake Inhibitors KW - 0 KW - Fluoxetine KW - 01K63SUP8D KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Hypothalamo-Hypophyseal System -- drug effects KW - Double-Blind Method KW - Arousal -- drug effects KW - Humans KW - Adult KW - Treatment Outcome KW - Cues KW - Middle Aged KW - Pituitary-Adrenal System -- drug effects KW - Male KW - Female KW - Substance Withdrawal Syndrome -- rehabilitation KW - Motivation KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Cocaine-Related Disorders -- psychology KW - Fluoxetine -- therapeutic use KW - Substance Withdrawal Syndrome -- psychology KW - Cocaine-Related Disorders -- rehabilitation KW - Hydrocortisone -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67209042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+drug+and+alcohol+abuse&rft.atitle=Fluoxetine+attenuates+adrenocortical+but+not+subjective+responses+to+cocaine+cues.&rft.au=Harris%2C+Debra+S%3BBatki%2C+Steven+L%3BBerger%2C+S+Paul&rft.aulast=Harris&rft.aufirst=Debra&rft.date=2004-11-01&rft.volume=30&rft.issue=4&rft.spage=765&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+drug+and+alcohol+abuse&rft.issn=00952990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-22 N1 - Date created - 2004-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structural requirements for efficient cellular photoprotection by carotenoid derivatives. AN - 67208630; 15623338 AB - We have synthesized five carotenoid derivatives: (1) Girard's reagent P (GRP)-retinal from GRP and retinal; (2) GRP-carotenal from GRP and beta-apo-8'-carotenal; (3) Girard's reagent T (GRT)-carotenal from GRT and beta-apo-8'-carotenal; (4) (GRP2-canthaxanthin from 2 mol of GRP and 1 mol of canthaxanthin; and (5) dansyl hydrazine (DH)-carotenal from DH and beta-apo-8'-carotenal. The first three derivatives are cations, whereas the fourth is a dication and the fifth is a weak base. Using K562 cells, we compared the subcellular distribution of the synthetic carotenoid derivatives with two uncharged natural carotenoids, beta-carotene and beta-apo-8'-carotenal. The two natural carotenoids were present mainly within the cell membranes. The synthetic carotenoid derivatives were more broadly distributed among the cell organelles. The positively charged derivatives had relatively high concentrations in mitochondria, whereas DH-carotenal had a relatively high concentration in lysosomes. We also measured the amount of photoprotection provided by the synthetic and natural carotenoids for K562 cells labeled with a photosensitizer (hypericin, protoporphyrin IX or cis-di[4-sulfonatophenyl]diphenylporphine). In this model system, only carotenoid derivatives with a permanent positive charge provided significant photoprotection. Neither the two natural carotenoids nor DH-carotenal were effective photoprotectors. JF - Photochemistry and photobiology AU - Kanofsky, Jeffrey R AU - Sima, Paul D AD - Medical Service, Edward Hines, Jr., Department of Veterans Affairs Hospital, Hines, IL 60141, USA. jeff.kanofsky@med.va.gov PY - 2004 SP - 507 EP - 517 VL - 80 IS - 3 SN - 0031-8655, 0031-8655 KW - Photosensitizing Agents KW - 0 KW - Carotenoids KW - 36-88-4 KW - Acridine Orange KW - F30N4O6XVV KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Molecular Structure KW - Acridine Orange -- chemistry KW - Spectrum Analysis KW - Cell Survival -- drug effects KW - Humans KW - Acridine Orange -- pharmacology KW - Cell Line, Tumor KW - Cell Survival -- radiation effects KW - Photosensitizing Agents -- pharmacology KW - Carotenoids -- chemical synthesis KW - Oxygen -- chemistry KW - Carotenoids -- chemistry KW - Carotenoids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67208630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Structural+requirements+for+efficient+cellular+photoprotection+by+carotenoid+derivatives.&rft.au=Kanofsky%2C+Jeffrey+R%3BSima%2C+Paul+D&rft.aulast=Kanofsky&rft.aufirst=Jeffrey&rft.date=2004-11-01&rft.volume=80&rft.issue=3&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-29 N1 - Date created - 2004-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis. AN - 67153208; 15582280 AB - A growing body of evidence indicates that dysregulation of cerebral biometals (Fe, Cu, Zn) and their interactions with APP and Abeta amyloid may contribute to the Alzheimer's amyloid pathology, and thus metal chelation could be a rational therapeutic approach for interdicting AD pathogenesis. However, poor target specificity and consequential clinical safety of current metal-complexing agents have limited their widespread clinical use. To develop the next generation of metal chelators, we have designed and synthesized a new bifunctional molecule-XH1, based on a novel 'pharmacophore conjugation' concept. This lipophilic molecule has both amyloid-binding and metal-chelating moieties covalently connected by amide bonds. It achieved a putative binding geometry with Abeta1-40 peptide by the computational chemistry modeling and reduced Zn(II)-induced Abeta1-40 aggregation in vitro as determined by turbidometry. Moreover, our pilot data indicated that XH1 has no significant neurotoxicity at low micromolar concentrations and acute animal toxicity. XH1 specifically reduced APP protein expression in human SH-SY5Y neuroblastoma cells and attenuated cerebral Abeta amyloid pathology in PS1/APP transgenic mice without inducing apparent toxicity and behavior disturbances. Collectively, these preliminary findings carry implication for XH1 being a BBB-permeable lead compound for AD therapeutics targeting Alzheimer's amyloidogenesis, although further studies are needed. JF - Experimental gerontology AU - Dedeoglu, Alpaslan AU - Cormier, Kerry AU - Payton, Sandra AU - Tseitlin, Katya A AU - Kremsky, Jonathan N AU - Lai, Li AU - Li, Xiaohua AU - Moir, Robert D AU - Tanzi, Rudolph E AU - Bush, Ashley I AU - Kowall, Neil W AU - Rogers, Jack T AU - Huang, Xudong AD - Geriatric Research Education and Clinical Center, Bedford Veterans' Administration Medical Center, Bedford, MA 01730, USA. PY - 2004 SP - 1641 EP - 1649 VL - 39 IS - 11-12 SN - 0531-5565, 0531-5565 KW - Amyloid beta-Peptides KW - 0 KW - Amyloid beta-Protein Precursor KW - Chelating Agents KW - Metals KW - Peptide Fragments KW - amyloid beta-protein (1-40) KW - Index Medicus KW - Peptide Fragments -- metabolism KW - Animals KW - Peptide Fragments -- genetics KW - Humans KW - Brain Chemistry KW - Peptide Fragments -- analysis KW - Aged KW - Amyloid beta-Protein Precursor -- metabolism KW - Mice KW - Immunohistochemistry -- methods KW - Brain -- metabolism KW - Cell Line, Tumor KW - Amyloid beta-Peptides -- analysis KW - Mice, Transgenic KW - Amyloid beta-Protein Precursor -- genetics KW - Neuroblastoma KW - Brain Neoplasms KW - Amyloid beta-Peptides -- genetics KW - Amyloid beta-Peptides -- metabolism KW - Amyloid beta-Protein Precursor -- analysis KW - Female KW - Chelating Agents -- therapeutic use KW - Chelating Agents -- chemical synthesis KW - Amyloidosis -- metabolism KW - Alzheimer Disease -- metabolism KW - Alzheimer Disease -- prevention & control KW - Amyloidosis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67153208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+gerontology&rft.atitle=Preliminary+studies+of+a+novel+bifunctional+metal+chelator+targeting+Alzheimer%27s+amyloidogenesis.&rft.au=Dedeoglu%2C+Alpaslan%3BCormier%2C+Kerry%3BPayton%2C+Sandra%3BTseitlin%2C+Katya+A%3BKremsky%2C+Jonathan+N%3BLai%2C+Li%3BLi%2C+Xiaohua%3BMoir%2C+Robert+D%3BTanzi%2C+Rudolph+E%3BBush%2C+Ashley+I%3BKowall%2C+Neil+W%3BRogers%2C+Jack+T%3BHuang%2C+Xudong&rft.aulast=Dedeoglu&rft.aufirst=Alpaslan&rft.date=2004-11-01&rft.volume=39&rft.issue=11-12&rft.spage=1641&rft.isbn=&rft.btitle=&rft.title=Experimental+gerontology&rft.issn=05315565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-21 N1 - Date created - 2004-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Male hormonal contraception. AN - 67140672; 15571489 AB - Although women have traditionally shouldered the responsibility of contraception, up to a third of couples worldwide employ a male form of contraception (e.g., condoms or vasectomy). Some women are unable to use hormonal contraception; vasectomy is best considered irreversible; and long-term use of condoms is associated with a relatively high failure rate (pregnancy). Thus, a need exists for a safe, effective, reversible, well-tolerated male hormonal contraceptive agent. Two large multi-centre, multi-national trials sponsored by the World Health Organization in the 1990s showed that high-dosage exogenous testosterone provided contraceptive efficacy similar to existing female oral contraceptives. However, the supraphysiological dosages of testosterone used resulted in androgen-related adverse effects such as weight gain and suppression of high-density lipoprotein cholesterol levels. Subsequent efforts have been directed at combining testosterone with other agents, such as progestogens or gonadotropin-releasing hormone analogues, to decrease the dosage of testosterone (and thus androgen-related side effects) while achieving uniform azoospermia. This review discusses the latest developments in male hormonal contraception. JF - Expert opinion on emerging drugs AU - Cornia, Paul B AU - Anawalt, Bradley D AD - VA Puget Sound Healthcare System, 1660 South Columbian Way (S-111-GIMC), Seattle, WA 98108-1597, USA. paul.cornia@med.va.gov Y1 - 2004/11// PY - 2004 DA - November 2004 SP - 335 EP - 344 VL - 9 IS - 2 KW - Androgens KW - 0 KW - Contraceptive Agents, Male KW - Drug Combinations KW - Progestins KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Testosterone KW - 3XMK78S47O KW - Index Medicus KW - Testosterone -- pharmacology KW - Humans KW - Progestins -- pharmacology KW - Gonadotropin-Releasing Hormone -- pharmacology KW - Gonadotropin-Releasing Hormone -- analogs & derivatives KW - Male KW - Spermatogenesis -- physiology KW - Contraceptive Agents, Male -- pharmacology KW - Contraception KW - Androgens -- adverse effects KW - Spermatogenesis -- drug effects KW - Androgens -- pharmacology KW - Contraceptive Agents, Male -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67140672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+emerging+drugs&rft.atitle=Male+hormonal+contraception.&rft.au=Cornia%2C+Paul+B%3BAnawalt%2C+Bradley+D&rft.aulast=Cornia&rft.aufirst=Paul&rft.date=2004-11-01&rft.volume=9&rft.issue=2&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+emerging+drugs&rft.issn=1744-7623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-24 N1 - Date created - 2004-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Complications and long-term survival for alcoholic patients with resectable lung cancer. AN - 67090839; 15546569 AB - The aim of this study was to determine the surgical risks and long-term survival in alcoholic patients undergoing resection for non-small-cell lung cancer. Nineteen resected patients comprising the alcoholic group were identified by either a Diagnostic and Statistical Manual of Mental Disorders-IV diagnosis of alcohol dependence/abuse, or an alcohol consumption of 60 oz/d or more. Alcoholic patients were compared with 37 nonalcoholic patients undergoing resection. Alcoholic patients had an increase in major infectious complications (37% [7 of 19] versus 5% [2 of 37], P = 0.005), respiratory failure (42% [8 of 19] versus 5% [2 of 37], P /=12 days. Neutrophil counts generally increased following discontinuation of vancomycin. One article reported successful resolution of neutropenia and infection by switching the patient's therapy to the structurally related antibiotic agent teicoplanin. Other patients were continued on vancomycin therapy, and neutropenia was treated with moderate to good success with filgrastim. Rechallenge was not generally attempted. The mechanism of neutropenia caused by vancomycin is unclear, but appears to be immune-mediated. Vancomycin therapy should not be prolonged unless absolutely necessary, and therapy should be reserved for patients with clear indications for the drug, such as infections due to gram-positive organisms resistant to other therapies. Patients should have periodic assessment of white blood cell and neutrophil counts with consideration to discontinue vancomycin if neutropenia develops. JF - The Annals of pharmacotherapy AU - Segarra-Newnham, Marisel AU - Tagoff, Shari S AD - Veterans Affairs Medical Center, West Palm Beach, FL, USA. marisel.segarra-newnham@med.va.gov Y1 - 2004/11// PY - 2004 DA - November 2004 SP - 1855 EP - 1859 VL - 38 IS - 11 SN - 1060-0280, 1060-0280 KW - Anti-Bacterial Agents KW - 0 KW - Vancomycin KW - 6Q205EH1VU KW - Index Medicus KW - Humans KW - Adult KW - Osteomyelitis -- drug therapy KW - Middle Aged KW - Child KW - Male KW - Female KW - Child, Preschool KW - Vancomycin -- adverse effects KW - Leukopenia -- chemically induced KW - Anti-Bacterial Agents -- adverse effects KW - Neutropenia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66986636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Probable+vancomycin-induced+neutropenia.&rft.au=Segarra-Newnham%2C+Marisel%3BTagoff%2C+Shari+S&rft.aulast=Segarra-Newnham&rft.aufirst=Marisel&rft.date=2004-11-01&rft.volume=38&rft.issue=11&rft.spage=1855&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-02-01 N1 - Date created - 2004-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of levofloxacin on the viability of intracellular Chlamydia pneumoniae and modulation of proinflammatory cytokine production by human monocytes AN - 20302082; 7583547 AB - Although antibiotics are known to affect the intracellular growth of Chlamydia pneumoniae in acute infections, their efficacy in therapy for chronic infections, including atherosclerosis, remains debatable. Human monocyte-derived macrophages (MDM) obtained from monocytes of healthy donors were infected with C. pneumoniae AR-39 and treated with levofloxacin (8 is a subset of g/mL) immediately after infection (0 hours) or 24 hours after infection. Levofloxacin treatment at 24 hours, but not at 0 hours, resulted in a significant decrease in the number of C. pneumoniae inclusions within the MDM (p < 0.05). Also decreased were concentrations of proinflammatory cytokines tumor necrosis factor- alpha (TNF- alpha ), interleukin (IL)-1 beta , IL-6, and IL-8 in the extracellular medium (p < 0.01). Viable counts in titrations remained similar to those in untreated controls. In summary, levofloxacin administered to MDM at serum-attainable levels 24 hours after C. pneumoniae infection significantly decreased inclusion counts and proinflammatory cytokine production, but did not eliminate the C. pneumoniae infection. JF - Diagnostic Microbiology and Infectious Disease AU - Baltch, Aldona L AU - Smith, Raymond P AU - Ritz, William J AU - Carpenter, Andrea N AU - Bopp, Lawrence H AU - Michelsen, Phyllis B AU - Carlyn, Cynthia J AU - Hibbs, Jonathan R AD - Stratton Veterans Affairs Medical Center, Albany, NY, USA, aldona.baltch@med.va.gov Y1 - 2004/11// PY - 2004 DA - Nov 2004 SP - 205 EP - 212 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 50 IS - 3 SN - 0732-8893, 0732-8893 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 6 KW - Macrophages KW - Levofloxacin KW - Antibiotics KW - Arteriosclerosis KW - Interleukin 8 KW - Inflammation KW - Chronic infection KW - Titration KW - Cytokines KW - Monocytes KW - Tumor necrosis factor- alpha KW - Chlamydophila pneumoniae KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20302082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+Microbiology+and+Infectious+Disease&rft.atitle=Effect+of+levofloxacin+on+the+viability+of+intracellular+Chlamydia+pneumoniae+and+modulation+of+proinflammatory+cytokine+production+by+human+monocytes&rft.au=Baltch%2C+Aldona+L%3BSmith%2C+Raymond+P%3BRitz%2C+William+J%3BCarpenter%2C+Andrea+N%3BBopp%2C+Lawrence+H%3BMichelsen%2C+Phyllis+B%3BCarlyn%2C+Cynthia+J%3BHibbs%2C+Jonathan+R&rft.aulast=Baltch&rft.aufirst=Aldona&rft.date=2004-11-01&rft.volume=50&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Diagnostic+Microbiology+and+Infectious+Disease&rft.issn=07328893&rft_id=info:doi/10.1016%2Fj.diagmicrobio.2004.07.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; Interleukin 6; Levofloxacin; Titration; Chronic infection; Cytokines; Antibiotics; Arteriosclerosis; Tumor necrosis factor- alpha; Monocytes; Interleukin 8; Inflammation; Chlamydophila pneumoniae DO - http://dx.doi.org/10.1016/j.diagmicrobio.2004.07.009 ER - TY - JOUR T1 - Violence in Healthcare Facilities: Lessons From the Veterans Health Administration AN - 17708415; 6109630 AB - Goals: The authors examined assault frequency and risk factors in health care. Methods: The authors conducted a cross-sectional questionnaire survey in 142 hospitals. Analyses are presented at the level of the individual and aggregated by facility. Results: Thirteen percent of employees described at least 1 assault in the last year; the proportion assaulted per facility ranged from 1% to 26%. Patients were the most common assaulters. Working in geriatrics, mental health, and rehabilitation or in nursing represented a high risk for assault. Hours of work and work patterns represented major risk factors for assault, as were higher measures of organizational stress. The penetration of training in alternate dispute resolution strategies was associated with lower rates of assaults. Conclusions: Although work in health care is associated with high rates of assaults, closer scrutiny suggests specific possible intervention strategies. JF - Journal of Occupational and Environmental Medicine AU - Hodgson, MJ AU - Reed, R AU - Craig, T AU - Murphy, F AU - Lehmann, L AU - Belton, L AU - Warren, N AD - Veterans Administration, muh7@mail.va.gov Y1 - 2004/11// PY - 2004 DA - Nov 2004 SP - 1158 EP - 1165 VL - 46 IS - 11 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Medical personnel KW - Mental disorders KW - Occupational exposure KW - Training KW - Stress KW - Violence KW - Health care KW - Hospitals KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17708415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Violence+in+Healthcare+Facilities%3A+Lessons+From+the+Veterans+Health+Administration&rft.au=Hodgson%2C+MJ%3BReed%2C+R%3BCraig%2C+T%3BMurphy%2C+F%3BLehmann%2C+L%3BBelton%2C+L%3BWarren%2C+N&rft.aulast=Hodgson&rft.aufirst=MJ&rft.date=2004-11-01&rft.volume=46&rft.issue=11&rft.spage=1158&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2F01.jom.0000141658.91805.47 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Health care; Hospitals; Stress; Violence; Medical personnel; Occupational exposure; Mental disorders; Training DO - http://dx.doi.org/10.1097/01.jom.0000141658.91805.47 ER - TY - JOUR T1 - Ventilatory responses to carbon dioxide at low and high levels of oxygen are elevated after episodic hypoxia in men compared with women AN - 17606472; 6041385 AB - We hypothesized that the acute ventilatory response to carbon dioxide in the presence of low and high levels of oxygen would increase to a greater extent in men compared with women after exposure to episodic hypoxia. Eleven healthy men and women of similar race, age, and body mass index completed a series of rebreathing trials before and after exposure to eight 4-min episodes of hypoxia. During the rebreathing trials, subjects initially hyperventilated to reduce the end-tidal partial pressure of carbon dioxide (PET sub(CO2)) below 25 Torr. Subjects then rebreathed from a bag containing a normocapnic (42 Torr), low (50 Torr), or high oxygen gas mixture (150 Torr). During the trials, PET sub(CO2) increased while the selected level of oxygen was maintained. The point at which minute ventilation began to rise in a linear fashion as PET sub(CO2) increased was considered to be the carbon dioxide set point. The ventilatory response below and above this point was determined. The results showed that the ventilatory response to carbon dioxide above the set point was increased in men compared with women before exposure to episodic hypoxia, independent of the oxygen level that was maintained during the rebreathing trials (50 Torr: men, 5.19 +/- 0.82 vs. women, 4.70 +/- 0.77 l.min super(-1).Torr super(-1); 150 Torr: men, 4.33 +/- 1.15 vs. women, 3.21 +/- 0.58 l.min super(-1).Torr super(-1)). Moreover, relative to baseline measures, the ventilatory response to carbon dioxide in the presence of low and high oxygen levels increased to a greater extent in men compared with women after exposure to episodic hypoxia (50 Torr: men, 9.52 +/- 1.40 vs. women, 5.97 +/- 0.71 l.min super(-1).Torr super(-1); 150 Torr: men, 5.73 +/- 0.81 vs. women, 3.83 +/- 0.56 l.min super(-1).Torr super(-1)). Thus we conclude that enhancement of the acute ventilatory response to carbon dioxide after episodic hypoxia is sex dependent. JF - Journal of Applied Physiology AU - Morelli, Chris AU - Badr, MSafwan AU - Mateika, Jason H AD - John D. Dingell Veterans Administration Medical Center, Department of Internal Medicine, Wayne State University School of Medicine, Department of Biomedical Engineering, Wayne State University, and Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan Y1 - 2004/11// PY - 2004 DA - Nov 2004 SP - 1673 EP - 1680 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA, [mailto:webmaster@the-aps.org], [URL:http://www.the-aps.org/] VL - 97 IS - 5 SN - 8750-7587, 8750-7587 KW - Physical Education Index KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17606472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Physiology&rft.atitle=Ventilatory+responses+to+carbon+dioxide+at+low+and+high+levels+of+oxygen+are+elevated+after+episodic+hypoxia+in+men+compared+with+women&rft.au=Morelli%2C+Chris%3BBadr%2C+MSafwan%3BMateika%2C+Jason+H&rft.aulast=Morelli&rft.aufirst=Chris&rft.date=2004-11-01&rft.volume=97&rft.issue=5&rft.spage=1673&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Physiology&rft.issn=87507587&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Intralabyrinthine fluid dynamics: Meniere disease. AN - 85373416; pmid-15377953 AB - Meniere disease has long been postulated to be a disorder of intralabyrinthine fluid dynamics.More recent developments in this field indicate that the control of fluid movement may be at a cellular level and that hormonal influence may be important.The control of fluid and ion movements through aquaporins and gap junctions in the cell membranes are creating new perspectives in the mechanism of development of endolymphatic hydrops as well as potential methods for treatment. Intralabyrinthine fluid dynamics also play a role in the ability to locally deliver drugs to the inner ear through the middle ear. JF - Current opinion in otolaryngology & head and neck surgery AU - Andrews, James C AD - Division of Head and Neck Surgery, Sepulveda-UCLA Veterans Administration Hospital, 16111 Plummer Street, Sepulveda, CA 91343, USA. jandrews@mednet.ucla.edu Y1 - 2004/10// PY - 2004 DA - Oct 2004 SP - 408 EP - 412 VL - 12 IS - 5 SN - 1068-9508, 1068-9508 KW - Index Medicus KW - National Library of Medicine KW - Combined Modality Therapy KW - *Endolymph: physiology KW - Endolymphatic Hydrops: physiopathology KW - Female KW - Humans KW - Injections, Intralymphatic KW - Labyrinthine Fluids: physiology KW - Male KW - *Meniere Disease: diagnosis KW - *Meniere Disease: drug therapy KW - Prognosis KW - Risk Assessment KW - Severity of Illness Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85373416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+otolaryngology+%26+head+and+neck+surgery&rft.atitle=Intralabyrinthine+fluid+dynamics%3A+Meniere+disease.&rft.au=Andrews%2C+James+C&rft.aulast=Andrews&rft.aufirst=James&rft.date=2004-10-01&rft.volume=12&rft.issue=5&rft.spage=408&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+otolaryngology+%26+head+and+neck+surgery&rft.issn=10689508&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Prognosis for Aphasia: Relationship between Selected Biographical and Behavioural Variables and Outcome and Improvement AN - 85335498; llba-200414506 AB - Numerous biographical & behavioral variables have been investigated for their prognostic value in aphasia. Tompkins, Jackson, & Schulz (1990) recommended ways to reconceptualize some of these variables & suggested exploration of additional variables that have been neglected. The purpose of this investigation was to examine the relationship between selected biographical & behavioral variables & initial performance, outcome, & amount of change in aphasia. A total of 34 participants, from the first Veterans Administration Cooperative Study on Aphasia, composed the study sample. Each was evaluated with the Porch Index of Communicative Ability (PICA) & the Rating of Functional Performance (RFP) (a modification of the Functional Communication Profile) at 4 & 48 weeks post-onset (WPO), before & after a 44-week treatment trial. Information for 10 biographical & behavioral variables was available for each participant at 4 WPO. Spearman's correlations were employed to determine the relationship between each biographical & behavioral variable & initial performance, outcome, & amount of change on the PICA & RFP. Performance at 4 WPO, pre-treatment, on the PICA & RFP was significantly correlated. Similarly, performance on the PICA & RFP at 4 WPO was significantly correlated with conversational, Token Test, & word fluency performance at 4 WPO. Outcome on the PICA & the RFP at 48 WPO, post-treatment, was significantly correlated with PICA, RFP, & word fluency performance at 4 WPO. Moreover, outcome on the PICA at 48 WPO was significantly correlated with conversational & Token Test performance at 4 WPO. Amount of change on the PICA between 4 WPO & 48 WPO was significantly negatively correlated with PICA, word fluency, Token Test, & conversational performance at 4 WPO. Amount of change on the RFP between 4 WPO & 48 WPO was significantly negatively correlated with RFP performance at 4 WPO. The results indicate that there are significant relationships between specific behavioral variables & initial performance, outcome, & amount of change on measures of language impairment & functional communication. Moreover, there is a difference between formulating a prognosis for outcome & amount of change in aphasia - individuals who attain higher outcomes do not necessarily make more improvement. However, the influence of a ceiling effect must be considered in this relationship. Finally, to determine the predictive precision of these relationships, future investigations will require a larger sample size & application of multiple regression analysis. 5 Tables, 47 References. Adapted from the source document JF - Aphasiology AU - de Riesthal, Michael AU - Wertz, Robert T AD - Dept Veterans Affairs, North Florida/South Georgia Healthcare System, Gainesville, FL michael.deriesthal2@med.va.gov Y1 - 2004/10// PY - 2004 DA - Oct 2004 SP - 899 EP - 915 VL - 18 IS - 10 SN - 0268-7038, 0268-7038 KW - *Fluency (24910) KW - *Prognostic Tests (68150) KW - *Language Therapy (44400) KW - *Interpersonal Behavior (37550) KW - *Aphasia (03400) KW - *Language Tests (44250) KW - *Statistical Analysis (83850) KW - *Communicative Competence (13650) KW - article KW - 6414: language-pathological and normal; aphasia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85335498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Prognosis+for+Aphasia%3A+Relationship+between+Selected+Biographical+and+Behavioural+Variables+and+Outcome+and+Improvement&rft.au=de+Riesthal%2C+Michael%3BWertz%2C+Robert+T&rft.aulast=de+Riesthal&rft.aufirst=Michael&rft.date=2004-10-01&rft.volume=18&rft.issue=10&rft.spage=899&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2004-12-01 N1 - Last updated - 2014-06-17 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - *Aphasia (03400); *Language Therapy (44400); *Prognostic Tests (68150); *Language Tests (44250); *Statistical Analysis (83850); *Interpersonal Behavior (37550); *Fluency (24910); *Communicative Competence (13650) ER - TY - JOUR T1 - Mass mailing and telephone contact were effective in recruiting veterans into an antibiotic treatment randomized clinical trial. AN - 67046645; 15528057 AB - Achieving enrollment goals of randomized clinical trials (RCT) within budgets depends on the timely recruitment of sufficient numbers of participants. We report a comparison of recruitment methods and yields of previously deployed veterans into a large RCT. A retrospective survey concerning recruitment was administered to staff at 28 sites participating in the VA Cooperative Study #475, "Antibiotic Treatment of Gulf War Veterans' Illnesses" (GWVI). Twenty-one sites reported identifying 31,407 Gulf War Veterans (GWV). Of these, 13.7% were successfully contacted, 3.5% were enrolled, and 1.2% were randomized. Mass mailings and direct telephone calls to GWV identified from a GWV database accounted for 78% of the GWV contacted. The other 22% were contacted by using referrals from medical staff, veterans' groups, media advertisements, and other methods. Data collected prospectively at the Albany Stratton VAMC were similar to data collected retrospectively from other sites. These findings demonstrate that in previously deployed GWV with GWVI, 1.2% could be randomized. Although the use of all recruitment methods combined achieved the study recruitment goal, these data demonstrate that mass mailing and direct telephone contacts were effective recruitment methods. JF - Journal of clinical epidemiology AU - Resio, Michael A AU - Baltch, Aldona L AU - Smith, Raymond P AD - Stratton VA Medical Center and Albany Medical College, Albany, NY 12208, USA. michael.resio@med.va.gov Y1 - 2004/10// PY - 2004 DA - October 2004 SP - 1063 EP - 1070 VL - 57 IS - 10 SN - 0895-4356, 0895-4356 KW - Anti-Bacterial Agents KW - 0 KW - Index Medicus KW - Anti-Bacterial Agents -- therapeutic use KW - Telephone KW - Humans KW - Retrospective Studies KW - Postal Service KW - Persian Gulf Syndrome -- drug therapy KW - Veterans KW - Randomized Controlled Trials as Topic KW - Communication KW - Patient Selection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67046645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+epidemiology&rft.atitle=Mass+mailing+and+telephone+contact+were+effective+in+recruiting+veterans+into+an+antibiotic+treatment+randomized+clinical+trial.&rft.au=Resio%2C+Michael+A%3BBaltch%2C+Aldona+L%3BSmith%2C+Raymond+P&rft.aulast=Resio&rft.aufirst=Michael&rft.date=2004-10-01&rft.volume=57&rft.issue=10&rft.spage=1063&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+epidemiology&rft.issn=08954356&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-01-11 N1 - Date created - 2004-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adverse events with disease modifying antirheumatic drugs (DMARD): a cohort study of leflunomide compared with other DMARD. AN - 66944865; 15468352 AB - To determine and compare the incidence of serious adverse events (AE) during treatment of rheumatoid arthritis (RA) with disease modifying antirheumatic drugs (DMARD), focusing on leflunomide (LEF). A retrospective cohort study of a large US insurance claims database was performed. Study groups were patients with RA classified by DMARD exposure as either no-DMARD therapy, single-agent DMARD (monotherapy), or combination-DMARD therapy. Specific DMARD examined were leflunomide (LEF) and methotrexate (MTX), compared to other DMARD (penicillamine, hydroxychloroquine, sulfasalazine, gold, etanercept, infliximab) and no DMARD (nonsteroidal antiinflammatory drugs, COX-2 inhibitors). All AE reported were considered endpoints; primary endpoints included hepatic, dermatologic, hematologic, infectious, respiratory, hypertension, and pancreatitis AE. The 40,594 RA patients of the study period (September 1998 to December 2000) accumulated 83,143 person-years (PY) of followup. Followup for each of the groups was: DMARD-monotherapy, 46,054 PY (55% of total); combination-DMARD, 25,830 PY (14%); and no-DMARD, 11,259 PY (14%). The incidence rate of all AE combined was significantly lower for LEF monotherapy (94 events/1000 PY) than MTX (145 events/1000 PY), other DMARD (143 events/1000 PY), or no DMARD (383 events/1000 PY) (p < 0.001 for all comparisons). The "all-AE" rates during combination therapy with LEF + MTX (43/1000 PY) and LEF + other DMARD (59/1000 PY) were lower than the "all-AE" rate for DMARD + MTX (70/1000 PY; p = 0.002). LEF monotherapy had the lowest rate of hepatic events in the DMARD monotherapy groups. The rates of AE in the LEF group, alone and combined with MTX, were generally lower than or comparable to the AE rates seen with MTX and other agents. JF - The Journal of rheumatology AU - Cannon, Grant W AU - Holden, William L AU - Juhaeri, Juhaeri AU - Dai, Wanju AU - Scarazzini, Linda AU - Stang, Paul AD - Veterans Affairs Salt Lake City Health Care System, Division of Rheumatology, University of Utah, Salt Lake City, Utah, USA. grant.cannon@med.va.gov Y1 - 2004/10// PY - 2004 DA - October 2004 SP - 1906 EP - 1911 VL - 31 IS - 10 SN - 0315-162X, 0315-162X KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Antirheumatic Agents KW - Isoxazoles KW - leflunomide KW - G162GK9U4W KW - Index Medicus KW - Humans KW - Cohort Studies KW - Adult KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Arthritis, Rheumatoid -- drug therapy KW - Isoxazoles -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Antirheumatic Agents -- adverse effects KW - Arthritis, Rheumatoid -- diagnosis KW - Isoxazoles -- therapeutic use KW - Antirheumatic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66944865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+rheumatology&rft.atitle=Adverse+events+with+disease+modifying+antirheumatic+drugs+%28DMARD%29%3A+a+cohort+study+of+leflunomide+compared+with+other+DMARD.&rft.au=Cannon%2C+Grant+W%3BHolden%2C+William+L%3BJuhaeri%2C+Juhaeri%3BDai%2C+Wanju%3BScarazzini%2C+Linda%3BStang%2C+Paul&rft.aulast=Cannon&rft.aufirst=Grant&rft.date=2004-10-01&rft.volume=31&rft.issue=10&rft.spage=1906&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+rheumatology&rft.issn=0315162X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-07-21 N1 - Date created - 2004-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Response of myasthenia gravis to rituximab in a patient with non-Hodgkin lymphoma. AN - 66924229; 15389902 AB - Myasthenia gravis is a B-cell-mediated autoimmune neuromuscular disorder characterized by weakness and fatigability of skeletal muscles. The underlying defect is an autoantibody-mediated attack on the acetylcholine receptors (AchRs) at the neuromuscular junction. Rituximab is a genetically engineered chimeric murine/human monoclonal antibody indicated for treatment of patients with low-grade or follicular, CD20-positive, B-cell non-Hodgkin lymphoma. Based on its potential for elimination of auto-reactive B-cell clones, rituximab may have a role in the management of some autoimmune disorders. We report a patient with B-cell, follicular non-Hodgkin lymphoma and a long-standing history of myasthenia gravis and the favorable impact of rituximab on both disorders. Copyright 2004 Wiley-Liss, Inc. JF - American journal of hematology AU - Gajra, Ajeet AU - Vajpayee, Neerja AU - Grethlein, Sara J AD - Department of Medicine, VA Medical Center, Syracuse, New York, USA. Ajeet.Gajra@med.va.gov Y1 - 2004/10// PY - 2004 DA - October 2004 SP - 196 EP - 197 VL - 77 IS - 2 SN - 0361-8609, 0361-8609 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Murine-Derived KW - Antineoplastic Agents KW - Cholinesterase Inhibitors KW - Rituximab KW - 4F4X42SYQ6 KW - Pyridostigmine Bromide KW - KVI301NA53 KW - Index Medicus KW - Cholinesterase Inhibitors -- adverse effects KW - Humans KW - Cholinesterase Inhibitors -- therapeutic use KW - Treatment Outcome KW - Pyridostigmine Bromide -- adverse effects KW - Aged KW - Pyridostigmine Bromide -- therapeutic use KW - Female KW - Myasthenia Gravis -- complications KW - Lymphoma, Non-Hodgkin -- drug therapy KW - Myasthenia Gravis -- drug therapy KW - Antineoplastic Agents -- administration & dosage KW - Lymphoma, Non-Hodgkin -- complications KW - Myasthenia Gravis -- enzymology KW - Antineoplastic Agents -- therapeutic use KW - Antibodies, Monoclonal -- administration & dosage KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66924229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hematology&rft.atitle=Response+of+myasthenia+gravis+to+rituximab+in+a+patient+with+non-Hodgkin+lymphoma.&rft.au=Gajra%2C+Ajeet%3BVajpayee%2C+Neerja%3BGrethlein%2C+Sara+J&rft.aulast=Gajra&rft.aufirst=Ajeet&rft.date=2004-10-01&rft.volume=77&rft.issue=2&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hematology&rft.issn=03618609&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-11-09 N1 - Date created - 2004-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Management of onychomycosis with topicals. AN - 66914957; 15450900 AB - Of all superficial fungal infections, onychomycosis is the most difficult to manage. Practitioners of all disciplines realize its chronic nature, difficulty in eradication, and propensity to recur. Topical treatment of onychomycosis, as opposed to oral therapies, offers a distinct advantage by allowing the patient to apply medication directly to the affected area, thus decreasing the potential for serious adverse events, such as drug toxicity and drug interactions. In the past, a multitude of topical antifungal agents were used in the treatment of onychomycosis; however, an acceptable level of scientific evidence regarding their effectiveness was lacking and this was evident by poor success rates. The development of a comparatively effective topical agent, the only one so far to gain FDA approval, has renewed interest in this form of therapy. Improved versions are being developed that may overcome the shortcomings of the first approved topical agent. JF - Clinics in podiatric medicine and surgery AU - Albert, Stephen F AU - Weis, Zak H AD - Department of Veterans Affairs Medical Center, Surgical Service, Podiatric Section (112), 1055 Clermont Street, Denver, CO 80220, USA. stephen.albert@med.va.gov Y1 - 2004/10// PY - 2004 DA - October 2004 SP - 605 EP - 15, vii VL - 21 IS - 4 SN - 0891-8422, 0891-8422 KW - Antifungal Agents KW - 0 KW - Pyridones KW - ciclopirox KW - 19W019ZDRJ KW - Index Medicus KW - Humans KW - Foot Dermatoses -- drug therapy KW - Administration, Topical KW - Pyridones -- administration & dosage KW - Antifungal Agents -- administration & dosage KW - Onychomycosis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66914957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+podiatric+medicine+and+surgery&rft.atitle=Management+of+onychomycosis+with+topicals.&rft.au=Albert%2C+Stephen+F%3BWeis%2C+Zak+H&rft.aulast=Albert&rft.aufirst=Stephen&rft.date=2004-10-01&rft.volume=21&rft.issue=4&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Clinics+in+podiatric+medicine+and+surgery&rft.issn=08918422&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-17 N1 - Date created - 2004-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Burden of general medical conditions among individuals with bipolar disorder. AN - 66903552; 15383128 AB - Treatment of coexisting medical comorbidities may reduce the risk of adverse outcomes among patients with bipolar disorder. We determined the prevalence of general medical conditions in a population-based sample of patients diagnosed with bipolar disorder in the Veterans Administration (VA). We conducted a cross-sectional study of patients (n = 4310) diagnosed with bipolar disorder in fiscal year 2001 receiving care at VA facilities located within the mid-Atlantic region. General medical conditions were assessed using ICD-9 codes, and we compared the prevalence of each condition in our bipolar sample with national data on the VA patient population. The mean age was 53 (SD = 13), 10% were women, and 12% African-American. The mean age of the VA national patient population was higher (58 years). The most prevalent conditions among patients with bipolar disorder included cardiovascular (e.g. hypertension, 35%), endocrine (e.g. hyperlipidemia, 23%; diabetes, 17%), and alcohol use disorder (25%). When compared with national data, the prevalence of diabetes was higher in the bipolar cohort than in the national cohort (17.2% versus 15.6%; p = 0.0035). Hepatitis C was more common in the bipolar group than the national cohort (5.9% versus 1.1%; p < 0.001). Lower back pain (15.4% versus 10.6%; p < 0.0001) and pulmonary conditions (e.g. COPD: 10.6% versus 9.4%; p = 0.005) were also more prevalent among the bipolar cohort than the VA national cohort. Individuals with bipolar disorder possess a substantial burden of general medical comorbidity, and are occurring at an earlier age than in the general VA patient population, suggesting the need for earlier detection and treatment for patients with bipolar disorder. JF - Bipolar disorders AU - Kilbourne, Amy M AU - Cornelius, Jack R AU - Han, Xiaoyan AU - Pincus, Harold A AU - Shad, Mujeeb AU - Salloum, Ihsan AU - Conigliaro, Joseph AU - Haas, Gretchen L AD - VA Pittsburgh Healthcare System, University of Pittsburgh, Pittsburgh, PA 15240, USA. amy.kilbourne@med.va.gov Y1 - 2004/10// PY - 2004 DA - October 2004 SP - 368 EP - 373 VL - 6 IS - 5 SN - 1398-5647, 1398-5647 KW - Index Medicus KW - Pulmonary Disease, Chronic Obstructive -- epidemiology KW - International Classification of Diseases KW - Humans KW - Retrospective Studies KW - Aged KW - Comorbidity KW - Cross-Sectional Studies KW - Hyperlipidemias -- epidemiology KW - Alcoholism -- epidemiology KW - Low Back Pain -- epidemiology KW - Cardiovascular Diseases -- epidemiology KW - Middle Aged KW - Hepatitis C -- epidemiology KW - Female KW - Male KW - Prevalence KW - Bipolar Disorder -- diagnosis KW - Bipolar Disorder -- epidemiology KW - Cost of Illness KW - Health Status KW - Bipolar Disorder -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66903552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bipolar+disorders&rft.atitle=Burden+of+general+medical+conditions+among+individuals+with+bipolar+disorder.&rft.au=Kilbourne%2C+Amy+M%3BCornelius%2C+Jack+R%3BHan%2C+Xiaoyan%3BPincus%2C+Harold+A%3BShad%2C+Mujeeb%3BSalloum%2C+Ihsan%3BConigliaro%2C+Joseph%3BHaas%2C+Gretchen+L&rft.aulast=Kilbourne&rft.aufirst=Amy&rft.date=2004-10-01&rft.volume=6&rft.issue=5&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=Bipolar+disorders&rft.issn=13985647&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-02-01 N1 - Date created - 2004-09-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intraluminal antibodies to macrophage migration inhibitory factor decrease substance P induced inflammatory changes in the rat bladder and prostate. AN - 66882991; 15371880 AB - Noxious stimuli induce substance P (SP) secretion from nerve terminals, resulting in plasma extravasation, edema and hyperalgesia, commonly referred to as neurogenic inflammation. Since SP is a short-lived molecule, additional proinflammatory mediators maintain continued inflammation. The bladder contains stores of preformed macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, which is released into the lumen in response to SP. MIF may act in an amplifying manner to maintain or increase inflammation. Inducing inflammatory changes with SP, while sequestering released luminal MIF with an antibody, tested this hypothesis. In anesthetized rats the ureters were cut to isolate the bladder and the bladder contents were replaced with saline or antiMIF antibody (5 or 15 microg/ml), immediately followed by systemic SP or saline. Changes in the expression of inflammatory cytokines, and histological changes in the bladder and prostate were evaluated 1 hour later. : Targeted array analysis identified increases in proinflammatory gene expression in the bladder and prostate as a result of SP. SP induced changes in MIF, cyclooxygenase-2, nerve growth factor, c-fos and edema were decreased by intraluminal anti-MIF. SP increased MIF amounts in the bladder lumen. Sequestering luminal MIF with an antiMIF antibody decreased SP induced inflammatory changes in the bladder and prostate, suggesting that MIF is involved in acute pelvic visceral neurogenic inflammation. These data indicate that MIF released from the bladder sustains or amplifies SP induced inflammation, a possibility that agrees with known MIF proinflammatory functions. These data continue to support our hypothesis that MIF is a new target for intervention in pelvic viscera inflammation. JF - The Journal of urology AU - Meyer-Siegler, Katherine L AU - Vera, Pedro L AD - Bay Pines Veterans Affairs Medical Center, Research and Development Service, Bay Pines, Florida 33744, USA. Katherine.Siegler@med.va.gov Y1 - 2004/10// PY - 2004 DA - October 2004 SP - 1504 EP - 1509 VL - 172 IS - 4 Pt 1 SN - 0022-5347, 0022-5347 KW - Antibodies KW - 0 KW - Cytokines KW - Macrophage Migration-Inhibitory Factors KW - Substance P KW - 33507-63-0 KW - Abridged Index Medicus KW - Index Medicus KW - Urinary Bladder -- pathology KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Prostate -- pathology KW - Cytokines -- metabolism KW - Male KW - Immunoenzyme Techniques KW - Macrophage Migration-Inhibitory Factors -- antagonists & inhibitors KW - Prostatitis -- chemically induced KW - Antibodies -- pharmacology KW - Cystitis -- pathology KW - Cystitis -- chemically induced KW - Substance P -- toxicity KW - Prostatitis -- pathology KW - Macrophage Migration-Inhibitory Factors -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66882991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Intraluminal+antibodies+to+macrophage+migration+inhibitory+factor+decrease+substance+P+induced+inflammatory+changes+in+the+rat+bladder+and+prostate.&rft.au=Meyer-Siegler%2C+Katherine+L%3BVera%2C+Pedro+L&rft.aulast=Meyer-Siegler&rft.aufirst=Katherine&rft.date=2004-10-01&rft.volume=172&rft.issue=4+Pt+1&rft.spage=1504&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-11-02 N1 - Date created - 2004-09-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quetiapine for treatment of alcohol dependence. AN - 66845368; 15349010 AB - Quetiapine is an atypical antipsychotic that has sedative effects. In this retrospective study, indices of alcohol use were compared for alcohol-dependent subjects who either were (n = 30) or were not (n = 20) treated with quetiapine (25 to 200 mg nightly) for disturbed sleep. Indices examined included total days of abstinence, number of hospitalizations for detoxification, and days to first relapse over 1 year of clinic treatment. Subjects were male veterans. All subjects had a diagnosis of alcohol dependence, and 90% of subjects in each group were also diagnosed with posttraumatic stress disorder. Both treatment groups contained a large number of subjects treated with psychiatric medications other than quetiapine. Significant differences were not found between the groups with respect to mean age, detoxifications undergone during the previous year, frequency of comorbid posttraumatic stress disorder or depression, or antidepressant use. The mean number of days abstinent was significantly greater, and the number of hospitalizations was significantly lower for the quetiapine than for the control group during the period studied. The mean number of days to relapse approached significance for the quetiapine as compared to the control group. This study has the usual limitations of a retrospective review, including the lack of standardized assessments of alcohol use. The results of this study are consistent with the hypothesis that the use of quetiapine to improve disturbed sleep may help alcohol-dependent patients maintain abstinence, although decreased drinking may also be a result of improving posttraumatic stress disorder symptoms or of a direct action of quetiapine to reduce alcohol use. JF - Journal of clinical psychopharmacology AU - Monnelly, Edward P AU - Ciraulo, Domenic A AU - Knapp, Clifford AU - LoCastro, Joseph AU - Sepulveda, Isaias AD - Division of Psychiatry, Boston University School of Medicine, Boston, MA 02118, USA. edward.monnelly@med.va.gov Y1 - 2004/10// PY - 2004 DA - October 2004 SP - 532 EP - 535 VL - 24 IS - 5 SN - 0271-0749, 0271-0749 KW - Alcohol Deterrents KW - 0 KW - Antipsychotic Agents KW - Dibenzothiazepines KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Index Medicus KW - Patient Readmission -- statistics & numerical data KW - Controlled Clinical Trials as Topic KW - Humans KW - Adult KW - Treatment Outcome KW - Retrospective Studies KW - Middle Aged KW - Temperance KW - Liver Function Tests KW - Secondary Prevention KW - Male KW - Alcoholism -- rehabilitation KW - Alcohol Deterrents -- adverse effects KW - Dibenzothiazepines -- adverse effects KW - Antipsychotic Agents -- therapeutic use KW - Veterans -- psychology KW - Antipsychotic Agents -- adverse effects KW - Dibenzothiazepines -- therapeutic use KW - Alcohol Deterrents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66845368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Quetiapine+for+treatment+of+alcohol+dependence.&rft.au=Monnelly%2C+Edward+P%3BCiraulo%2C+Domenic+A%3BKnapp%2C+Clifford%3BLoCastro%2C+Joseph%3BSepulveda%2C+Isaias&rft.aulast=Monnelly&rft.aufirst=Edward&rft.date=2004-10-01&rft.volume=24&rft.issue=5&rft.spage=532&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-01-28 N1 - Date created - 2004-09-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relation of Shyness with Aspects of Online Relationship Involvement AN - 60543089; 200500317 AB - Relationships that individuals develop using an online medium constitute a relatively new way of forming personal attachments with others. Researchers have only recently begun to explore online relationship involvement & the personality characteristics that may draw individuals to use this medium for relationship development. Although certain aspects have been proposed, including loneliness & social anxiety, to date only a few studies have explored these issues. The primary focus of this study involved examining the relation of participants' shyness with identical aspects of online & face-to-face relational involvement. University students were surveyed, with 146 reporting involvement in at least one online relationship. Results indicated that correlations of shyness with aspects of involvement in online relationships were greater than those with involvement in face-to-face relationships. However, shyness was not significantly related to aspects of online relationship involvement. Other findings included the comparability of surveys measuring both face-to-face & online relational involvement & the relationship of participants' sex with aspects of involvement in online relationships. 4 Tables, 23 References. [Reprinted by permission of Sage Publications Ltd., copyright 2004.] JF - Journal of Social and Personal Relationships AU - Ward, Christopher C AU - Tracey, Terence J G AD - VHA National Center Organization Development, Cincinnati, OH christopher.ward2@med.va.gov Y1 - 2004/10// PY - 2004 DA - October 2004 SP - 611 EP - 623 VL - 21 IS - 5 SN - 0265-4075, 0265-4075 KW - shyness KW - Dating (Social) KW - Interpersonal Relations KW - College Students KW - Internet KW - article KW - 1772: sociology of science; sociology of technology KW - 0312: social psychology; personality & social roles (individual traits, social identity, adjustment, conformism, & deviance) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60543089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Social+and+Personal+Relationships&rft.atitle=Relation+of+Shyness+with+Aspects+of+Online+Relationship+Involvement&rft.au=Ward%2C+Christopher+C%3BTracey%2C+Terence+J+G&rft.aulast=Ward&rft.aufirst=Christopher&rft.date=2004-10-01&rft.volume=21&rft.issue=5&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+and+Personal+Relationships&rft.issn=02654075&rft_id=info:doi/10.1177%2F0265407504045890 LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Number of references - 23 N1 - Last updated - 2016-09-28 N1 - CODEN - JSRLE9 N1 - SubjectsTermNotLitGenreText - Interpersonal Relations; Internet; College Students; Dating (Social) DO - http://dx.doi.org/10.1177/0265407504045890 ER - TY - JOUR T1 - The Adherent Gastric Mucous Layer Is Composed of Alternating Layers of MUC5AC and MUC6 Mucin Proteins AN - 20794870; 6083673 AB - Mucin-type glycoproteins are the major structural proteins in gastric mucus. Stomach mucin proteins include MUC5AC, synthesized by surface foveolar or pit cells, and MUC6, synthesized by neck and gland cells. The aim of this study was to determine the spatial distribution of these mucin proteins within the extracellular mucous coat. Double-labeling immunoflourescence/confocal microscopy was used in histologically normal surgical resection specimens. Intralumenal mucin within antral glands consisted entirely of MUC6 protein. Intralumenal mucin within the gland isthmus region consisted of an irregular mixture of MUC5AC and MUC6. The mucous layer on the gastric surface consisted primarily of MUC5AC extending in layered sheets with MUC6 protein layered in between. The laminated appearance of the surface mucus was present in both H. pylori-infected and noninfected specimens. These data indicate that MUC5AC and MUC6 proteins remain segregated within the mucous gel in a laminated linear arrangement. The physical stratification of mucin proteins may confer increased strength to the mucous layer or represent independent and redundant protection. JF - Digestive Diseases and Sciences AU - Ho, S B AU - Takamura, K AU - Anway, R AU - Shekels, L L AU - Toribara, N W AU - Ota, H AD - Department of Medicine, Veterans Affairs Medical Center and University of Minnesota, Minneapolis, Minnesota, USA, Samuel.Ho@med.va.gov Y1 - 2004/10// PY - 2004 DA - Oct 2004 SP - 1598 EP - 1606 PB - Kluwer Academic Publishers VL - 49 IS - 10 SN - 0163-2116, 0163-2116 KW - Microbiology Abstracts B: Bacteriology KW - Spatial distribution KW - Glands KW - Confocal microscopy KW - mucin KW - Mucus KW - Glycoproteins KW - Neck KW - Stomach KW - Structural proteins KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20794870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+Diseases+and+Sciences&rft.atitle=The+Adherent+Gastric+Mucous+Layer+Is+Composed+of+Alternating+Layers+of+MUC5AC+and+MUC6+Mucin+Proteins&rft.au=Ho%2C+S+B%3BTakamura%2C+K%3BAnway%2C+R%3BShekels%2C+L+L%3BToribara%2C+N+W%3BOta%2C+H&rft.aulast=Ho&rft.aufirst=S&rft.date=2004-10-01&rft.volume=49&rft.issue=10&rft.spage=1598&rft.isbn=&rft.btitle=&rft.title=Digestive+Diseases+and+Sciences&rft.issn=01632116&rft_id=info:doi/10.1023%2FB%3ADDAS.0000043371.12671.98 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Spatial distribution; Glands; Confocal microscopy; mucin; Mucus; Glycoproteins; Neck; Structural proteins; Stomach DO - http://dx.doi.org/10.1023/B:DDAS.0000043371.12671.98 ER - TY - JOUR T1 - Risk Factors Relating Blood Markers of Inflammation and Nutritional Status to Survival in Cachectic Geriatric Patients in a Randomized Clinical Trial AN - 20718240; 6222556 AB - Objectives: To evaluate the effect of proinflammatory cytokines, their receptors, and nutritional indicators (at baseline and after 12 weeks of megestrol acetate (MA) treatment) upon long-term survival in geriatric cachectic patients without active acute infections, inflammation, or cancer. Design: Randomized clinical trial with placebo or MA treatment for 12 weeks and then follow-up for more than 4 years. Setting: Veterans Affairs nursing home in Northport, New York. Participants: Nursing home patients with weight loss of 5% of usual body weight over the previous 3 months or body weight 20% below ideal body weight. Intervention: Random assignment of placebo or MA oral suspension 800 mg-d to the eligible patients for 12 weeks. Measurements: White blood cell counts, prealbumin, plasma cytokine levels (or their receptors), including tumor necrosis factor receptor (TNFR), soluble subunits (TNFR-p55 and TNFR-p75), interleukin (IL)-6, soluble IL-2 receptor, and C-reactive protein at baseline and 12 weeks after treatment. Results: There was no difference in survival between the MA and placebo groups. Considering possible confounders, initial IL-6, initial TNFR-p75 levels, and final neutrophil percentage were associated with elevated mortality, whereas higher initial prealbumin, initial albumin, final prealbumin, final albumin, and final weight gain were associated with decreased death. Conclusion: In geriatric weight-loss patients with cachexia, certain cytokines and nutritional indicators were effective in predicting long-term mortality, regardless of treatment with MA. Interventions to modify levels of these cytokines or their receptors and improvement in nutritional status by weight gain might be helpful in ameliorating undetected chronic inflammation and thus might prolong the survival of these nursing home residents. JF - Journal of the American Geriatrics Society AU - Yeh, Shing-shing AU - Hafner, Alice AU - Chang, Chin-Kuo AU - Levine, Daniel M AU - Parker, Thomas S AU - Schuster, Michael W AD - Box 111, VAMC Northport, 79 Middleville Road, Northport, NY 11768, Shingshing.Yeh@med.va.gov Y1 - 2004/10// PY - 2004 DA - Oct 2004 SP - 1708 EP - 1712 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 52 IS - 10 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - Mortality KW - obesity KW - tumors KW - clinical trials KW - Nutrition KW - Cancer KW - USA, New York KW - intervention KW - infection KW - Proteins KW - survival KW - body weight KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20718240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Risk+Factors+Relating+Blood+Markers+of+Inflammation+and+Nutritional+Status+to+Survival+in+Cachectic+Geriatric+Patients+in+a+Randomized+Clinical+Trial&rft.au=Yeh%2C+Shing-shing%3BHafner%2C+Alice%3BChang%2C+Chin-Kuo%3BLevine%2C+Daniel+M%3BParker%2C+Thomas+S%3BSchuster%2C+Michael+W&rft.aulast=Yeh&rft.aufirst=Shing-shing&rft.date=2004-10-01&rft.volume=52&rft.issue=10&rft.spage=1708&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2004.52465.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - SuppNotes - Figures, 1; tables, 2; references, 30. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; intervention; infection; obesity; Proteins; tumors; clinical trials; survival; body weight; Nutrition; Cancer; USA, New York DO - http://dx.doi.org/10.1111/j.1532-5415.2004.52465.x ER - TY - JOUR T1 - Veterans Administration support for medical research: opinions of the endangered species of physician-scientists AN - 19700681; 6040913 AB - Over the past three decades the Veterans Affairs (VA) Research program has evolved into a powerful, peer-reviewed funding mechanism for basic and translational research that has resulted in numerous important contributions to medical science and improvements in patient care. Continuity in VA Merit Review funding has fostered and nurtured the scientific careers of a large number of physician-scientists who have remained devoted to the mission of performing creative and innovative research that affects the patient care mission of the VA. VA medical research policies have undergone a major overhaul in the past year. Although many of these changes (de-emphasizing bench research and revamping the peer review process) have recently been reversed, the future direction of VA research remains in flux. The goal of this manuscript is to demonstrate the importance of the Merit Review medical research funding mechanism not just to the VA, but to the entire nation's health care system. To achieve this goal, the opinions of 65 established VA medical investigators were obtained regarding the past success and future direction of VA research. The conclusions reached include the following. 1) Merit Review research funding has been essential to the training, recruitment, and retention of productive VA physician-scientists. 2) The VA research program has contributed both basic and clinical innovations that have led to improvements in medical care. Contributions of VA researchers to excellence in many aspects of patient care at VA hospitals have been extraordinary. 3) Development of initiatives that entice outstanding Ph.D.'s to develop their careers in the VA has been crucial to the success of the program. 4) The VA research program has fostered a mutually beneficial relationship with affiliated medical schools. 5) Better methods to quantify VA research contributions and outcomes are essential for future program development.-Zucker, S., Crabbe, J. C., Cooper, G., IV, Finkelman, F., Largman, C., McCarley, R. W., Rice, L., Rubin, J., Richardson, B., Seil, F., Snider, G. L., Vandenbark, A. A. Veterans Administration support for medical research: opinions of the endangered species of physician-scientists. JF - FASEB Journal AU - Zucker, Stanley AU - Crabbe, John C AU - Cooper, George AU - Finkelman, Fred AU - Largman, Corey AU - Mccarley, Robert W AU - Rice, Louis AU - Rubin, Janet AU - Richardson, Bruce AU - Seil, Frederick AU - Snider, Gordon L AU - Vandenbark, Arthur A AD - Veterans Administration Medical Centers located in. Northport, New York, USA Y1 - 2004/10// PY - 2004 DA - Oct 2004 SP - 1481 EP - 1486 PB - Federation of American Societies for Experimental Biology, 9650 Rockville Pike Bethesda MD 20814 USA, [URL:http://www.fasebj.org] VL - 18 IS - 13 SN - 0892-6638, 0892-6638 KW - Sustainability Science Abstracts KW - Training KW - Oryza sativa KW - medical research KW - careers KW - schools KW - Health care KW - Reviews KW - Endangered species KW - recruitment KW - innovations KW - Research programs KW - Hospitals KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19700681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+Journal&rft.atitle=Veterans+Administration+support+for+medical+research%3A+opinions+of+the+endangered+species+of+physician-scientists&rft.au=Zucker%2C+Stanley%3BCrabbe%2C+John+C%3BCooper%2C+George%3BFinkelman%2C+Fred%3BLargman%2C+Corey%3BMccarley%2C+Robert+W%3BRice%2C+Louis%3BRubin%2C+Janet%3BRichardson%2C+Bruce%3BSeil%2C+Frederick%3BSnider%2C+Gordon+L%3BVandenbark%2C+Arthur+A&rft.aulast=Zucker&rft.aufirst=Stanley&rft.date=2004-10-01&rft.volume=18&rft.issue=13&rft.spage=1481&rft.isbn=&rft.btitle=&rft.title=FASEB+Journal&rft.issn=08926638&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - careers; Health care; schools; Training; Reviews; recruitment; Endangered species; innovations; medical research; Research programs; Hospitals; Oryza sativa ER - TY - JOUR T1 - Elbow anatomy and structural biomechanics AN - 17851931; 6068258 AB - The elbow joint provides an important link in the upper extremity between the shoulder and the hand. Certain occupations and activities expose the elbow to increased amounts of stress, which can lead to traumatic or overuse type injuries. This article discusses the basic anatomy of the elbow and the biomechanics of this joint. A combination of bony articulation and soft-tissue stabilizers accounts for the elbow's stability and complex kinematics. Knowledge of the anatomy and biomechanics is essential to understanding potential sites and etiologies of pathologic conditions in the elbow joint. JF - Clinics in Sports Medicine AU - Alcid, J G AU - Ahmad, C S AU - Lee, T Q AD - Orthopaedic Biomechanics Laboratory, Veterans Administration Long Beach Healthcare System, 5901 East 7th Street, Long Beach, CA 90822, USA, tqlee@med.va.gov Y1 - 2004/10// PY - 2004 DA - Oct 2004 SP - 503 EP - 517 VL - 23 IS - 4 SN - 0278-5919, 0278-5919 KW - Physical Education Index KW - Hands KW - Kinematics KW - Injuries KW - Stress KW - Stability KW - Knowledge KW - Anatomy KW - Joints KW - Elbows KW - Shoulders KW - Activities KW - Biomechanics KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17851931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+Sports+Medicine&rft.atitle=Elbow+anatomy+and+structural+biomechanics&rft.au=Alcid%2C+J+G%3BAhmad%2C+C+S%3BLee%2C+T+Q&rft.aulast=Alcid&rft.aufirst=J&rft.date=2004-10-01&rft.volume=23&rft.issue=4&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=Clinics+in+Sports+Medicine&rft.issn=02785919&rft_id=info:doi/10.1016%2Fj.csm.2004.06.008 LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Elbows; Joints; Anatomy; Biomechanics; Activities; Knowledge; Shoulders; Kinematics; Hands; Stability; Stress; Injuries DO - http://dx.doi.org/10.1016/j.csm.2004.06.008 ER - TY - JOUR T1 - Molecular Methods for Diagnosis of Viral Encephalitis AN - 17712218; 6062067 AB - Hundreds of viruses cause central nervous system (CNS) disease, including meningoencephalitis and postinfectious encephalomyelitis, in humans. The cerebrospinal fluid (CSF) is abnormal in >90% of cases; however, routine CSF studies only rarely lead to identification of a specific etiologic agent. Diagnosis of viral infections of the CNS has been revolutionized by the advent of new molecular diagnostic technologies to amplify viral nucleic acid from CSF, including PCR, nucleic acid sequence-based amplification, and branched-DNA assay. PCR is ideally suited for identifying fastidious organisms that may be difficult or impossible to culture and has been widely applied for detection of both DNA and RNA viruses in CSF. The technique can be performed rapidly and inexpensively and has become an integral component of diagnostic medical practice in the United States and other developed countries. In addition to its use for identification of etiologic agents of CNS disease in the clinical setting, PCR has also been used to quantitate viral load and monitor duration and adequacy of antiviral drug therapy. PCR has also been applied in the research setting to help discriminate active versus postinfectious immune- mediate disease, identify determinants of drug resistance, and investigate the etiology of neurologic disease of uncertain cause. This review discusses general principles of PCR and reverse transcription-PCR, including qualitative, quantitative, and multiplex techniques, with comment on issues of sensitivity, specificity, and positive and negative predictive values. The application of molecular diagnostic methods for diagnosis of specific infectious entities is reviewed in detail, including viruses for which PCR is of proven efficacy and is widely available, viruses for which PCR is less widely available or for which PCR has unproven sensitivity and specificity, and nonviral entities which can mimic viral CNS disease. JF - Clinical Microbiology Reviews AU - Debiasi, Roberta L AU - Tyler, Kenneth L AD - Department of Pediatrics, Division of Infectious Diseases. Department of Neurology. Department of Medicine, Microbiology and Immunology, University of Colorado Health Sciences Center. Denver Veterans Administration Medical Center, Denver, Colorado Y1 - 2004/10// PY - 2004 DA - Oct 2004 SP - 903 EP - 925 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 17 IS - 4 SN - 0893-8512, 0893-8512 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Central nervous system KW - Etiology KW - Drug resistance KW - Meningoencephalitis KW - Transcription KW - RNA viruses KW - Encephalomyelitis KW - Infection KW - DNA viruses KW - Encephalitis KW - Cerebrospinal fluid KW - nucleic acids KW - Antiviral agents KW - Reviews KW - Polymerase chain reaction KW - A 01114:Viruses KW - V 22022:Virus assay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17712218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+Reviews&rft.atitle=Molecular+Methods+for+Diagnosis+of+Viral+Encephalitis&rft.au=Debiasi%2C+Roberta+L%3BTyler%2C+Kenneth+L&rft.aulast=Debiasi&rft.aufirst=Roberta&rft.date=2004-10-01&rft.volume=17&rft.issue=4&rft.spage=903&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+Reviews&rft.issn=08938512&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Central nervous system; Etiology; Drug resistance; Meningoencephalitis; Transcription; Encephalomyelitis; RNA viruses; Infection; DNA viruses; Encephalitis; Cerebrospinal fluid; nucleic acids; Antiviral agents; Reviews; Polymerase chain reaction ER - TY - JOUR T1 - Heart failure alters the strength and mechanisms of arterial baroreflex pressor responses during dynamic exercise AN - 17698832; 6030228 AB - Arterial baroreflex function is well preserved during dynamic exercise in normal subjects. In subjects with heart failure (HF), arterial baroreflex ability to regulate blood pressure is impaired at rest. However, whether exercise modifies the strength and mechanisms of baroreflex responses in HF is unknown. Therefore, we investigated the relative roles of cardiac output and peripheral vasoconstriction in eliciting the pressor response to bilateral carotid occlusion (BCO) in conscious, chronically instrumented dogs at rest and during treadmill exercise ranging from mild to heavy workloads. Experiments were performed in the same animals before and after rapid ventricular pacing-induced HF. At rest, the pressor response to BCO was significantly attenuated in HF (33.3 +/- 1.2 vs. 18.7 +/- 2.7 mmHg), and this difference persisted during exercise in part due to lower cardiac output responses in HF. However, both before and after the induction of HF, the contribution of vasoconstriction in active skeletal muscle toward the pressor response became progressively greater as workload increased. We conclude that, although there is an impaired ability of the baroreflex to regulate arterial pressure at rest and during exercise in HF, vasoconstriction in active skeletal muscle becomes progressively more important in mediating the baroreflex pressor response as workload increases with a pattern similar to that observed in normal subjects. JF - American Journal of Physiology: Heart and Circulatory Physiology AU - Kim, Jong-Kyung AU - Augustyniak, Robert A AU - Sala-Mercado, Javier A AU - Hammond, Robert L AU - Ansorge, Eric J AU - Rossi, Noreen F AU - O'leary, Donal S AD - Department of Physiology, Department of Surgery, and Department of Internal Medicine, Wayne State University School of Medicine, and John D. Dingell Veterans Administration Medical Center, Detroit, Michigan Y1 - 2004/10// PY - 2004 DA - Oct 2004 SP - H1682 EP - H1688 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA, [mailto:webmaster@the-aps.org], [URL:http://www.the-aps.org/] VL - 287 IS - 4 SN - 0363-6135, 0363-6135 KW - Physical Education Index KW - Exercise physiology KW - Strength KW - Exercise (effects) KW - Blood pressure KW - Heart diseases KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17698832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Heart+and+Circulatory+Physiology&rft.atitle=Heart+failure+alters+the+strength+and+mechanisms+of+arterial+baroreflex+pressor+responses+during+dynamic+exercise&rft.au=Kim%2C+Jong-Kyung%3BAugustyniak%2C+Robert+A%3BSala-Mercado%2C+Javier+A%3BHammond%2C+Robert+L%3BAnsorge%2C+Eric+J%3BRossi%2C+Noreen+F%3BO%27leary%2C+Donal+S&rft.aulast=Kim&rft.aufirst=Jong-Kyung&rft.date=2004-10-01&rft.volume=287&rft.issue=4&rft.spage=H1682&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Heart+and+Circulatory+Physiology&rft.issn=03636135&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Strength; Heart diseases; Exercise (effects); Exercise physiology; Blood pressure ER - TY - JOUR T1 - Overview of the Veterans Health Administration (VHA) Quality Enhancement Research Initiative (QUERI) AN - 17687630; 6006506 AB - The U.S. Veterans Health Administration (VHA)'s Quality Enhancement Research Initiative (QUERI) is an innovative integration of health services research, policy, and clinical care delivery designed to improve the quality, outcomes, and efficiency of VHA health care through the identification and implementation of evidence-based practices in routine care settings. A total of eight condition-specific QUERI centers are currently in operation, each pursuing an integrated portfolio of activities designed to identify and correct gaps in clinical quality and performance and to derive generalizable scientific knowledge regarding quality improvement processes and methods and their effectiveness. This overview article describes QUERI's mission, history, structure, and activities and provides a brief summary of key findings and impacts. JF - Journal of the American Medical Informatics Association AU - Mcqueen, Lynn AU - Mittman, Brian S AU - Demakis, John G AD - Office of Quality and Performance (LM), Quality Enhancement Research Initiative (BSM), Health Services Research and Development Service (JGD), U.S. Department of Veterans Affairs, Washington, DC. Y1 - 2004/10// PY - 2004 DA - Oct 2004 SP - 339 EP - 343 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org] VL - 11 IS - 5 SN - 1067-5027, 1067-5027 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - W4 140:Bioinformatics & Computers in Health & Medicine KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17687630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=Overview+of+the+Veterans+Health+Administration+%28VHA%29+Quality+Enhancement+Research+Initiative+%28QUERI%29&rft.au=Mcqueen%2C+Lynn%3BMittman%2C+Brian+S%3BDemakis%2C+John+G&rft.aulast=Mcqueen&rft.aufirst=Lynn&rft.date=2004-10-01&rft.volume=11&rft.issue=5&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - A Comparison of Multiple Data Sources to Identify Vaccinations for Veterans with Spinal Cord Injuries and Disorders AN - 17589334; 6006511 AB - Monitoring vaccination activity requires regular access to information about patient vaccination status. This report describes our experience using multiple Department of Veterans Affairs (VA) data sources to determine availability and completeness of vaccination information for veterans with spinal cord injuries and disorders (SCI&D). Administrative and clinical databases were limited to coding vaccine administration, undercounted vaccinations, and were unable to account for whether the vaccine was offered and the reasons for nonreceipt. Medical record review provided more detail but was labor intensive and costly. Patient surveys provided the richest information but were costly, time- consuming, and based on a sample of patients. Agreement was poor between data sources. This report suggests that while VA is well positioned to use national databases for clinical care decisions and to inform policy, vaccination data were incomplete. Electronic records must include data that are consistently entered and validated before they can be useful for care management and decision making. JF - Journal of the American Medical Informatics Association AU - Weaver, Frances M AU - Hatzakis, Michael AU - Evans, Charlesnika T AU - Smith, Bridget AU - Lavela, Sherri L AU - Wallace, Carolyn AU - Legro, Marcia W AU - Goldstein, Barry AD - Spinal Cord Injury Quality Enhancement Research Initiative, Midwest Center for Health Services and Policy Research, Hines Veterans Administration Hospital, Hines, IL, and Institute for Health Services and Policy Research, Northwestern University, Chicago, IL (FMW) Y1 - 2004/10// PY - 2004 DA - Oct 2004 SP - 377 EP - 379 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org] VL - 11 IS - 5 SN - 1067-5027, 1067-5027 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Decision making KW - Databases KW - medical records KW - Severe combined immunodeficiency KW - Bioinformatics KW - Spinal cord injury KW - Vaccines KW - Vaccination KW - W4 140:Bioinformatics & Computers in Health & Medicine KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17589334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=A+Comparison+of+Multiple+Data+Sources+to+Identify+Vaccinations+for+Veterans+with+Spinal+Cord+Injuries+and+Disorders&rft.au=Weaver%2C+Frances+M%3BHatzakis%2C+Michael%3BEvans%2C+Charlesnika+T%3BSmith%2C+Bridget%3BLavela%2C+Sherri+L%3BWallace%2C+Carolyn%3BLegro%2C+Marcia+W%3BGoldstein%2C+Barry&rft.aulast=Weaver&rft.aufirst=Frances&rft.date=2004-10-01&rft.volume=11&rft.issue=5&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Vaccination; Vaccines; Databases; Spinal cord injury; medical records; Severe combined immunodeficiency; Decision making; Bioinformatics ER - TY - JOUR T1 - Respiratory symptoms and intensity of occupational dust exposure AN - 16204102; 6282862 AB - Objectives: Occupational exposure to dusts may result in chronic respiratory symptoms. Methods: To investigate the utility of obtaining a history of occupational exposure to dust in US veterans, a respiratory health survey was conducted between 1988 and 1992 in a community-based cohort of US veterans in southeastern Massachusetts that were eligible for Veterans' Affairs (VA) healthcare benefits but were not regular users. A mail questionnaire was used to obtain a history of cough, phlegm, and wheeze, work in a dusty job, and duration, type, and intensity of dust exposure. Information on cigarette use and other possible confounders was obtained. Results: In 2,617 white men, after the data had been adjusted for cigarette smoking, age, distance to the nearest major roadway, and chronic respiratory disease, the relative odds of chronic cough, chronic phlegm, and persistent wheeze attributable to occupational dust exposure was increased twofold. Risk also increased, based on exposure intensity. For heavy dust exposure the OR was 1.98 (95% CI 1.39-2.81) for chronic cough, 2.82 (95% CI 2.03-3.93) for chronic phlegm, and 2.70 (95% CI 1.95-3.75) for persistent wheeze. Conclusions: After active cigarette smoking and other possible confounders had been considered, it was found that dust exposure was related to respiratory symptoms in US veterans and that the greatest risk was attributable to heavy intensity exposure. JF - International Archives of Occupational and Environmental Health AU - Garshick, Eric AU - Laden, Francine AU - Hart, Jaime E AU - Moy, Marilyn L AD - VA Boston Healthcare System, 1400 VFW Parkway, West Roxbury, Massachusetts, MA 02132, USA, eric.garshick@med.va.gov Y1 - 2004/10// PY - 2004 DA - Oct 2004 SP - 515 EP - 520 PB - Springer-Verlag (Berlin), Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 77 IS - 7 SN - 0340-0131, 0340-0131 KW - Toxicology Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Historical account KW - USA, Massachusetts KW - Cough KW - Respiratory diseases KW - Dust KW - Respiratory tract diseases KW - Health care KW - Cigarette smoking KW - Military KW - Occupational exposure KW - X 24156:Environmental impact KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16204102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Archives+of+Occupational+and+Environmental+Health&rft.atitle=Respiratory+symptoms+and+intensity+of+occupational+dust+exposure&rft.au=Garshick%2C+Eric%3BLaden%2C+Francine%3BHart%2C+Jaime+E%3BMoy%2C+Marilyn+L&rft.aulast=Garshick&rft.aufirst=Eric&rft.date=2004-10-01&rft.volume=77&rft.issue=7&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=International+Archives+of+Occupational+and+Environmental+Health&rft.issn=03400131&rft_id=info:doi/10.1007%2Fs00420-004-0534-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-08-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Respiratory tract diseases; Cigarette smoking; Cough; Occupational exposure; Dust; Historical account; Health care; Respiratory diseases; Military; USA, Massachusetts DO - http://dx.doi.org/10.1007/s00420-004-0534-1 ER - TY - JOUR T1 - Evidence-based practices for safe patient handling and movement. AN - 66976175; 15482090 AB - Efforts to reduce injuries associated with patient handling are often based on tradition and personal experience rather than scientific evidence. The purpose of this article is to summarize current evidence for interventions designed to reduce caregiver injuries, a significant problem for decades. Despite strong evidence, published over three decades, the most commonly used strategies have strong evidence that demonstrate they are ineffective. There is a growing body of evidence to support newer interventions that are effective or show promise in reducing musculoskeletal pain and injuries in care providers. The authors have organized potential solutions into three established ergonomic solution types: engineering based, administrative, and behavioral. For each intervention, the level of evidence to support its use is provided. JF - Online journal of issues in nursing AU - Nelson, Audrey AU - Baptiste, Andrea S AD - James A. Haley Veterans Hospital in Tampa, Florida, USA. audrey.nelson@med.va.gov Y1 - 2004/09/30/ PY - 2004 DA - 2004 Sep 30 SP - 4 VL - 9 IS - 3 KW - Index Medicus KW - Nursing KW - Musculoskeletal Diseases -- prevention & control KW - Human Engineering -- methods KW - Humans KW - Occupational Diseases -- prevention & control KW - Health Policy KW - Education, Nursing, Continuing -- methods KW - Patient Care Team -- organization & administration KW - Risk Assessment KW - Nursing -- instrumentation KW - Evidence-Based Medicine -- methods KW - Lifting KW - Nursing -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66976175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Online+journal+of+issues+in+nursing&rft.atitle=Evidence-based+practices+for+safe+patient+handling+and+movement.&rft.au=Nelson%2C+Audrey%3BBaptiste%2C+Andrea+S&rft.aulast=Nelson&rft.aufirst=Audrey&rft.date=2004-09-30&rft.volume=9&rft.issue=3&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Online+journal+of+issues+in+nursing&rft.issn=1091-3734&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-18 N1 - Date created - 2004-10-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Orthop Nurs. 2006 Nov-Dec;25(6):366-79 [17130758] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Advancing cancer care through technology AN - 39986935; 3866239 AU - Kobb, R AU - Chumbler, N AU - Richardson, L AU - Todd, C AU - McCarthy, C AU - Lodge, R AU - Morris, K AU - Demanuel, L Y1 - 2004/09/21/ PY - 2004 DA - 2004 Sep 21 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39986935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Advancing+cancer+care+through+technology&rft.au=Kobb%2C+R%3BChumbler%2C+N%3BRichardson%2C+L%3BTodd%2C+C%3BMcCarthy%2C+C%3BLodge%2C+R%3BMorris%2C+K%3BDemanuel%2C+L&rft.aulast=Kobb&rft.aufirst=R&rft.date=2004-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Amer. Telemedicine Assn., 1100 Connecticut Avenue NW, Washington, DC 20036, USA; URL: www.americantelemed.org N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Security and interconnection of radiology devices to healthcare networks AN - 39859333; 3884687 AU - Seymour, D M Y1 - 2004/09/21/ PY - 2004 DA - 2004 Sep 21 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39859333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Security+and+interconnection+of+radiology+devices+to+healthcare+networks&rft.au=Seymour%2C+D+M&rft.aulast=Seymour&rft.aufirst=D&rft.date=2004-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: CARS Conference Office, Im Gut 11-15, D-79790 Kuessaberg, F.R. Germany; URL: www.cars-int.de N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Comparison of custom sounds for achieving tinnitus relief. AN - 85405211; pmid-15553658 AB - Tinnitus masking has been a widely used method for treating clinically significant tinnitus. The method, referred to herein as "sound-based relief," typically uses wearable ear-level devices ("maskers") to effect palliative tinnitus relief. Although often effective, this approach is limited to the use of broadband noise with the maskers. We hypothesized that the effectiveness of treatment can be improved by expanding the auditory-stimulus options available to patients. A pilot study was conducted to determine for each of 21 subjects the most effective of custom sounds that are designed to promote tinnitus relief. While sitting in a sound booth, subjects listened to white noise and to custom sounds that are available commercially for providing tinnitus relief. Three sound formats ("E-Water," "E-Nature," and "E-Air") were provided by the Dynamic Tinnitus Mitigation (DTM-6a) system (Petroff Audio Technologies, Inc.). Additionally, seven sounds were provided by the Moses/Lang CD7 system (Oregon Hearing Research Center). Considering group data, all of the sounds provided a significant reduction in tinnitus annoyance relative to the annoyance of tinnitus alone. Two of the commercial sounds (DTM E-Nature and E-Water) were judged significantly more effective than the other sounds. JF - Journal of the American Academy of Audiology AU - Henry, James A AU - Rheinsburg, Betsy AU - Zaugg, Tara AD - VA RR&D National Center for Rehabilitative Auditory Research, Portland VA Medical Center, OR 97207, USA. james.henry@med.va.gov Y1 - 2004/09// PY - 2004 DA - Sep 2004 SP - 585 EP - 598 VL - 15 IS - 8 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - *Acoustic Stimulation: methods KW - Aged KW - Aged, 80 and over KW - Audiometry, Pure-Tone KW - Auditory Threshold KW - Female KW - Humans KW - Male KW - Middle Aged KW - *Perceptual Masking KW - Pilot Projects KW - Psychoacoustics KW - *Tinnitus: psychology KW - *Tinnitus: therapy KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85405211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Comparison+of+custom+sounds+for+achieving+tinnitus+relief.&rft.au=Henry%2C+James+A%3BRheinsburg%2C+Betsy%3BZaugg%2C+Tara&rft.aulast=Henry&rft.aufirst=James&rft.date=2004-09-01&rft.volume=15&rft.issue=8&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: J Am Acad Audiol. 2004 Sep;15(8):540[15553653] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Global-local visual processing in posttraumatic stress disorder. AN - 85396018; pmid-15327718 AB - The purpose of this study was to examine a behavioral index of hemispheric asymmetry (i.e., visual hierarchical attention) in posttraumatic stress disorder (PTSD), a disorder characterized by anxiety and other emotional symptoms. A reaction time based, computerized, global-local visual paradigm was administered to 26 PTSD-diagnosed and 22 psychopathology-free right-handed, male Vietnam War zone veterans. Results indicated that PTSD-diagnosed veterans displayed slower reaction times to all targets than the no-mental disorders comparison sample. However, findings also revealed a Group x Target location interaction in which the PTSD group was slower than the no-disorders comparison sample to respond to local, but not global, targets. Moreover, relative global bias was greater among PTSD-diagnosed veterans than their no-diagnosis counterparts. Findings provide partial support for the hypothesis that PTSD may be associated with a functional cerebral asymmetry favoring the right hemisphere. JF - Journal of the International Neuropsychological Society : JINS AU - Vasterling, Jennifer J AU - Duke, Lisa M AU - Tomlin, Holly AU - Lowery, Natasha AU - Kaplan, Edith AD - Veterans Affairs Medical Center, New Orleans, Louisiana 70112, USA. jennifer.vasterling@med.va.gov Y1 - 2004/09// PY - 2004 DA - Sep 2004 SP - 709 EP - 718 VL - 10 IS - 5 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Analysis of Variance KW - *Attention: physiology KW - Combat Disorders: physiopathology KW - Functional Laterality: physiology KW - Humans KW - Male KW - Middle Aged KW - *Neuropsychological Tests KW - Personality Inventory KW - Photic Stimulation KW - Psychiatric Status Rating Scales KW - Reaction Time: physiology KW - *Stress Disorders, Post-Traumatic: physiopathology KW - Veterans KW - *Visual Perception: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Global-local+visual+processing+in+posttraumatic+stress+disorder.&rft.au=Vasterling%2C+Jennifer+J%3BDuke%2C+Lisa+M%3BTomlin%2C+Holly%3BLowery%2C+Natasha%3BKaplan%2C+Edith&rft.aulast=Vasterling&rft.aufirst=Jennifer&rft.date=2004-09-01&rft.volume=10&rft.issue=5&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Sensory testing of the esophagus. AN - 85395893; pmid-15319643 AB - Originally, sensory testing of the esophagus included the acid perfusion test and the edrophonium test, which were developed to assess patients with non-cardiac chest pain. In the last 2 decades interest in functional esophageal disorders has increased and thus further understanding of the underlying mechanisms of esophageal pain required development of new sensory testing techniques. Balloon distension using a computerized electronic device, electrical stimulation and impedance planimetry have generated important information about esophageal sensory thresholds for pain in different disease states. Intraluminal ultrasonography has been used to determine the physiologic changes of the muscle wall of the esophagus during perception of typical esophageal symptoms. Central evaluation of patients undergoing esophageal stimulation has recently been introduced to assess cerebral activation in different esophageal disorders. However, many studies using esophageal sensory testing are afflicted with significant design flaws, making interpretation of the results very difficult. This is primarily due to lack of recognition of factors that can modulate esophageal sensation. JF - Journal of clinical gastroenterology AU - Fass, Ronnie AD - Neuro-Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson, Arizona 85723, USA. Ronnie.Fass@med.VA.gov Y1 - 2004/09// PY - 2004 DA - Sep 2004 SP - 628 EP - 641 VL - 38 IS - 8 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Acids: diagnostic use KW - Balloon Dilation KW - Brain: physiology KW - Cholinesterase Inhibitors: diagnostic use KW - Edrophonium: diagnostic use KW - Electric Impedance KW - Electric Stimulation KW - *Esophagus: physiology KW - Esophagus: ultrasonography KW - Evoked Potentials KW - Humans KW - Proton Pumps: antagonists & inhibitors KW - *Sensation: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85395893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Sensory+testing+of+the+esophagus.&rft.au=Fass%2C+Ronnie&rft.aulast=Fass&rft.aufirst=Ronnie&rft.date=2004-09-01&rft.volume=38&rft.issue=8&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Risk stratification of Barrett's esophagus: updated prospective multivariate analysis. AN - 85389728; pmid-15330898 AB - Prospective evaluation of Barrett's esophagus (BE) in order to determine what demographic, endoscopic, and histologic features are predictive of the prevalence and incidence of Barrett's high-grade dysplasia (HGD) and adenocarcinoma (Ca).Newly diagnosed BE patients were entered into and followed in a standardized surveillance protocol. The following features were examined using either forward, stepwise multiple regression analysis, or Cox proportional hazards to determine their ability to predict the presence of HGD or Ca at index BE diagnosis as well as their ability to predict progression of BE during follow-up: age, race, gender, length of BE in cm, size of a hiatal hernia, severity of dysplasia at index diagnosis as well as during surveillance, gastric Helicobacter pylori infection status, and type of medical acid-reflux treatment.A total of 550 patients were diagnosed with BE over the study period. Stepwise multiple regression analysis showed three factors significantly associated with index diagnosis of HGD or Ca: hiatal hernia (larger size), Barrett's length (longer length), and absence of H. pylori infection. Three hundred and twenty-four BE entered the surveillance protocol. Cox proportional hazards models revealed a significant and independent association for five factors predictive of the time to progression of BE: presence of dysplasia at index diagnosis (p < 0.001), severity of dysplasia during surveillance (p < 0.001), length of Barrett's epithelium (p= 0.012), size of hiatal hernia (p= 0.006), and gastric H. pylori infection status (p= 0.023).Endoscopic and histologic features of BE at initial diagnosis are predictive of index HGD and cancer as well as with risk of BE progression. JF - The American journal of gastroenterology AU - Weston, Allan P AU - Sharma, Prateek AU - Mathur, Sharad AU - Banerjee, Sushanta AU - Jafri, A Khatib AU - Cherian, Rachel AU - McGregor, Douglas AU - Hassanein, Ruth S AU - Hall, Matthew AD - Veterans Administration Medical Center 111C, 4801 E. Linwood Boulevard, Kansas City, MO 64128-2226, USA. Y1 - 2004/09// PY - 2004 DA - Sep 2004 SP - 1657 EP - 1666 VL - 99 IS - 9 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Adenocarcinoma: epidemiology KW - *Adenocarcinoma: pathology KW - Age Distribution KW - Aged KW - Barrett Esophagus: epidemiology KW - *Barrett Esophagus: pathology KW - Biopsy, Needle KW - Case-Control Studies KW - Esophageal Neoplasms: epidemiology KW - *Esophageal Neoplasms: pathology KW - Esophagoscopy KW - Female KW - Humans KW - Immunohistochemistry KW - Kansas: epidemiology KW - Male KW - Middle Aged KW - Multivariate Analysis KW - *Precancerous Conditions: pathology KW - Predictive Value of Tests KW - Prevalence KW - Probability KW - Prognosis KW - Proportional Hazards Models KW - Prospective Studies KW - Regression Analysis KW - Risk Assessment KW - Sex Distribution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85389728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Risk+stratification+of+Barrett%27s+esophagus%3A+updated+prospective+multivariate+analysis.&rft.au=Weston%2C+Allan+P%3BSharma%2C+Prateek%3BMathur%2C+Sharad%3BBanerjee%2C+Sushanta%3BJafri%2C+A+Khatib%3BCherian%2C+Rachel%3BMcGregor%2C+Douglas%3BHassanein%2C+Ruth+S%3BHall%2C+Matthew&rft.aulast=Weston&rft.aufirst=Allan&rft.date=2004-09-01&rft.volume=99&rft.issue=9&rft.spage=1657&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Prediction of fall risk reduction as measured by dynamic gait index in individuals with unilateral vestibular hypofunction. AN - 85379316; pmid-15354006 AB - To determine the effect of vestibular rehabilitation on reduction of fall risk in individuals with unilateral vestibular hypofunction and to identify those factors that predict fall risk reduction.Retrospective chart review.Tertiary referral center.Forty-seven patients with unilateral vestibular hypofunction, aged 28 to 86 years, who were at risk for falls on initial assessment.All patients underwent vestibular rehabilitation including adaptation exercises, designed to improve gaze stability, and gait and balance exercises.Fall risk (Dynamic Gait Index), visual acuity during head movements (Dynamic Visual Acuity), and subjective complaints were measured initially, at 2-week intervals, and at completion of physical therapy.As a group, the patients had significantly reduced risk for falls (p or = 65 yr) and younger (< 65 yr) adults showed significant reductions in fall risk with vestibular rehabilitation (p <0.001). However, a significantly greater proportion (Chi2= 0.016) of older adults remained at risk for falls at discharge compared with young adults (45% versus 11%). Initial Dynamic Gait Index and Dynamic Visual Acuity scores predicted fall risk reduction in patients with unilateral vestibular hypofunction. A model was developed using initial Dynamic Gait Index and Dynamic Visual Acuity scores to predict fall risk reduction.Vestibular rehabilitation is effective in significantly reducing fall risk in individuals with unilateral vestibular deficit. The model predicts fall risk reduction with good sensitivity (77%) and specificity (90%). JF - Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology AU - Hall, Courtney D AU - Schubert, Michael C AU - Herdman, Susan J AD - Rehabilitation Research and Development, Atlanta Veterans Administration, Decatur, Georgia 30322, USA. chall7@emory.edu Y1 - 2004/09// PY - 2004 DA - Sep 2004 SP - 746 EP - 751 VL - 25 IS - 5 SN - 1531-7129, 1531-7129 KW - Index Medicus KW - National Library of Medicine KW - *Accidental Falls: prevention & control KW - *Accidental Falls: statistics & numerical data KW - Adult KW - Aged KW - Aged, 80 and over KW - *Exercise Therapy: methods KW - Female KW - Humans KW - Male KW - Middle Aged KW - *Postural Balance KW - Retrospective Studies KW - Risk Reduction Behavior KW - Treatment Outcome KW - Vestibular Diseases: complications KW - *Vestibular Diseases: rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85379316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otology+%26+neurotology+%3A+official+publication+of+the+American+Otological+Society%2C+American+Neurotology+Society+%5Band%5D+European+Academy+of+Otology+and+Neurotology&rft.atitle=Prediction+of+fall+risk+reduction+as+measured+by+dynamic+gait+index+in+individuals+with+unilateral+vestibular+hypofunction.&rft.au=Hall%2C+Courtney+D%3BSchubert%2C+Michael+C%3BHerdman%2C+Susan+J&rft.aulast=Hall&rft.aufirst=Courtney&rft.date=2004-09-01&rft.volume=25&rft.issue=5&rft.spage=746&rft.isbn=&rft.btitle=&rft.title=Otology+%26+neurotology+%3A+official+publication+of+the+American+Otological+Society%2C+American+Neurotology+Society+%5Band%5D+European+Academy+of+Otology+and+Neurotology&rft.issn=15317129&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Oxidative damage precedes nitrative damage in adriamycin-induced cardiac mitochondrial injury. AN - 67183590; 15605432 AB - The purpose of the present study was to determine if elevated reactive oxygen (ROS)/nitrogen species (RNS) reported to be present in adriamycin (ADR)-induced cardiotoxicity actually resulted in cardiomyocyte oxidative/nitrative damage, and to quantitatively determine the time course and subcellular localization of these postulated damage products using an in vivo approach. B6C3 mice were treated with a single dose of 20 mg/kg ADR. Ultrastructural damage and levels of 4-hydroxy-2-nonenal (4HNE)-protein adducts and 3-nitrotyrosine (3NT) were analyzed. Quantitative ultrastructural damage using computerized image techniques showed cardiomyocyte injury as early as 3 hours, with mitochondria being the most extensively and progressively injured subcellular organelle. Analysis of 4HNE protein adducts by immunogold electron microscopy showed appearance of 4HNE protein adducts in mitochondria as early as 3 hours, with a peak at 6 hours and subsequent decline at 24 hours. 3NT levels were significantly increased in all subcellular compartments at 6 hours and subsequently declined at 24 hours. Our data showed ADR induced 4HNE-protein adducts in mitochondria at the same time point as when mitochondrial injury initially appeared. These results document for the first time in vivo that mitochondrial oxidative damage precedes nitrative damage. The progressive nature of mitochondrial injury suggests that mitochondria, not other subcellular organelles, are the major site of intracellular injury. JF - Toxicologic pathology AU - Chaiswing, Luksana AU - Cole, Marsha P AU - St Clair, Daret K AU - Ittarat, Wanida AU - Szweda, Luke I AU - Oberley, Terry D AD - Department of Pathology and Laboratory Medicine, William S. Middleton Memorial Veterans Administration Hospital and University of Wisconsin Medical School, Madison WI 53705, USA. PY - 2004 SP - 536 EP - 547 VL - 32 IS - 5 SN - 0192-6233, 0192-6233 KW - Antineoplastic Agents KW - 0 KW - Reactive Nitrogen Species KW - Reactive Oxygen Species KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Disease Models, Animal KW - Mice KW - Microscopy, Immunoelectron KW - Immunohistochemistry KW - Myocardium -- metabolism KW - Male KW - Reactive Oxygen Species -- metabolism KW - Cardiomyopathies -- metabolism KW - Cardiomyopathies -- pathology KW - Oxidative Stress KW - Antineoplastic Agents -- toxicity KW - Mitochondria, Heart -- drug effects KW - Reactive Nitrogen Species -- metabolism KW - Doxorubicin -- toxicity KW - Cardiomyopathies -- chemically induced KW - Mitochondria, Heart -- metabolism KW - Mitochondria, Heart -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67183590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Oxidative+damage+precedes+nitrative+damage+in+adriamycin-induced+cardiac+mitochondrial+injury.&rft.au=Chaiswing%2C+Luksana%3BCole%2C+Marsha+P%3BSt+Clair%2C+Daret+K%3BIttarat%2C+Wanida%3BSzweda%2C+Luke+I%3BOberley%2C+Terry+D&rft.aulast=Chaiswing&rft.aufirst=Luksana&rft.date=2004-09-01&rft.volume=32&rft.issue=5&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-01-04 N1 - Date created - 2004-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Outcomes of substance use disorder treatment in suicidal and nonsuicidal male patients. AN - 67064734; 15536775 AB - Numerous studies report high rates of substance-related problems and psychopathology in substance use disorder (SUD) patients with a history of a suicide attempt. However, little is known about the response of suicidal SUD patients to treatment. This study examined the treatment outcomes of suicidal and nonsuicidal SUD patients who were followed for 5 years. A total of 2099 male SUD patients were recruited from 15 Department of Veterans Affairs residential alcohol and drug treatment programs and were assessed at four points (treatment entry, discharge, and 1 and 5 years later). Approximately 7% (n = 156) of the patients reported a suicide attempt in the 3 months prior to the start of treatment. Although patients with a recent suicide attempt reported severe patterns of alcohol use and elevated psychiatric symptoms at baseline, they showed significant improvements in both of these domains at discharge from residential treatment, and these improvements were still evident at 1-year and 5-year follow-ups. Suicidal SUD patients were no more likely to leave treatment early than were nonsuicidal patients, and they received slightly longer and more individualized treatment. Despite a more severe pattern of alcohol use and psychiatric symptoms at baseline, suicidal SUD patients benefitted substantially from residential SUD treatment. These findings imply that suicidal SUD patients can be treated effectively within SUD treatment settings. JF - Journal of studies on alcohol AU - Ilgen, Mark A AU - Tiet, Quyen AU - Moos, Rudolf AD - Center for Health Care Evaluation, Department of Veterans Affairs Palo Alto Health Care System, California, USA. Mark.Ilgen@med.va.gov Y1 - 2004/09// PY - 2004 DA - September 2004 SP - 643 EP - 650 VL - 65 IS - 5 SN - 0096-882X, 0096-882X KW - Index Medicus KW - United States KW - Humans KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Longitudinal Studies KW - United States Department of Veterans Affairs -- statistics & numerical data KW - Male KW - Substance-Related Disorders -- therapy KW - Suicide, Attempted -- psychology KW - Substance-Related Disorders -- psychology KW - Suicide, Attempted -- prevention & control KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67064734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Outcomes+of+substance+use+disorder+treatment+in+suicidal+and+nonsuicidal+male+patients.&rft.au=Ilgen%2C+Mark+A%3BTiet%2C+Quyen%3BMoos%2C+Rudolf&rft.aulast=Ilgen&rft.aufirst=Mark&rft.date=2004-09-01&rft.volume=65&rft.issue=5&rft.spage=643&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-02-08 N1 - Date created - 2004-11-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antiarrhythmic and proarrhythmic properties of QT-prolonging antianginal drugs. AN - 66892038; 15378133 AB - In recent years there has been a major reorientation of drug therapy for cardiac arrhythmias, its changing role, and above all, a radical change in the class of arrhythmia drugs because of their impact on mortality. The decline in the use of sodium-channel blockers has led to an ex panding use of beta-blockers and simple or complex class III agents for controlling cardiac arrhythmias. Success with these agents in the context of their side effects has spurred the development of compounds with simpler ion-channel blocking properties that have less complex adverse reactions. The resulting so-called pure class III agents, such as dofetilide or ibutilide, were found to have antifibrillatory effects in atrial fibrillation and flutter and in ventricular tachyarrhythmias. Such agents are effective and have diversity, but they have come into therapeutics with a price: the sometimes-fatal torsades de pointes. The drug amiodarone, a complex compound that was synthesized as an antianginal agent, has been an exception in this regard. Its therapeutic use is associated with a negligibly low incidence of torsades de pointes, even though the drug produces significant bradycardia and QT lengthening to 500 to 700 msec. Recent electrophysiologic studies suggest that this paradox is likely due to the differential block of ion channels in endocardium, epicardium, midmyocardial (M) cells, and Purkinje fibers in the ventricular myocardium. There is also clinical evidence suggesting that amiodarone reduces the "torsadogenic" effects of pure class III agents. Ranolazine was also synthesized for the development of antianginal properties that stem from a partial inhibition of fatty acid oxidation; it too has been found to have electrophysioloigic properties. These are somewhat similar to those of amiodarone on ion channels in endocardium, epicardium, M cells, and Purkinje fibers in the ventricular myocardium, but the drug does not prolong the QT interval to the same extent as amiodarone does. Thus, the drug produces modest increases in repolarization as judged by its effects on the action potential duration (APD) without the potential for the development of torsades de pointes. By virtue of its suppressant action on early afterdepolarizations and triggered activity in Purkinje fibers and M cells, the drug appears to have a powerful potential for reducing the torsadogenic proclivity of conventional class III antiarrhythmic compounds. The rationale for the therapeutic niche for amiodarone, and especially in the case of ranolazine, in the prevention of drug-induced torsades de pointes is discussed. JF - Journal of cardiovascular pharmacology and therapeutics AU - Singh, Bramah N AU - Wadhani, Nitin AD - Division of Cardiology, Veterans Administration Greater Los Angeles Healthcare System and the David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, CA 90073, USA. bsingh@ucla.edu Y1 - 2004/09// PY - 2004 DA - September 2004 SP - S85 EP - S97 VL - 9 Suppl 1 SN - 1074-2484, 1074-2484 KW - Anti-Arrhythmia Agents KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Electrocardiography KW - Clinical Trials as Topic KW - Angina Pectoris -- prevention & control KW - Long QT Syndrome -- chemically induced KW - Anti-Arrhythmia Agents -- classification KW - Angina Pectoris -- drug therapy KW - Long QT Syndrome -- prevention & control KW - Torsades de Pointes -- prevention & control KW - Long QT Syndrome -- drug therapy KW - Torsades de Pointes -- chemically induced KW - Torsades de Pointes -- drug therapy KW - Anti-Arrhythmia Agents -- adverse effects KW - Anti-Arrhythmia Agents -- therapeutic use KW - Angina Pectoris -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66892038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.atitle=Antiarrhythmic+and+proarrhythmic+properties+of+QT-prolonging+antianginal+drugs.&rft.au=Singh%2C+Bramah+N%3BWadhani%2C+Nitin&rft.aulast=Singh&rft.aufirst=Bramah&rft.date=2004-09-01&rft.volume=9+Suppl+1&rft.issue=&rft.spage=S85&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.issn=10742484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-28 N1 - Date created - 2004-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multicenter drug use evaluation of tamsulosin and availability of guidance criteria for nonformulary use in the veterans affairs health system. AN - 66880951; 15369425 AB - The U.S. Department of Veterans Affairs (VA) Pharmacy Benefits Management Strategic Healthcare Group (PBM-SHG) and its Medical Advisory Panel developed national criteria (guidelines) for the appropriate use of tamsulosin in the VA. Drug use evaluation (DUE) was performed to (a) determine the prescribing patterns (indications and patient follow-up monitoring as measured by a clinician.s note regarding evaluation of therapeutic response or report of adverse drug event) of tamsulosin, (b) assess the impact of the availability (not active dissemination) of national criteria for nonformulary use of tamsulosin, and (c) project the cost avoidance if generic terazosin was substituted for tamsulosin in those patients who were prescribed tamsulosin outside of appropriate use criteria. Geographically dispersed VA medical centers were identified for which tamsulosin utilization was significantly above and below the national average (4.8% of all prescriptions for alpha [alpha]-blockers) in January 2001. A data collection form for medical record abstraction was designed to capture the patient.s diagnosis, reported indication for tamsulosin, history of previous alpha-blocker use, tamsulosin follow-up evaluation, and the individual facility.s method of implementation of criteria for nonformulary use. Patients receiving a prescription for tamsulosin during a 3-month period preceding the posting of national criteria, and patients with a first-time prescription for tamsulosin during a 3-month period after the national criteria were posted were randomly selected by the PBM and assigned for chart review at each site. Data for 332 patients were collected from 6 different sites over a 6-month period for each pregroup and postgroup beginning August 2001 and January 2002, respectively. Tamsulosin was prescribed for appropriate indications in 66% of patients, potentially appropriate indications in 4% of patients, and inappropriate indications in 30% of patients. Of the 206 patients (62%) who were prescribed tamsulosin as a result of a reported adverse event with a previous alpha-blocker, only 29% of the cases (N = 59) showed evidence that an attempt was made to reduce the dose of the first alpha-blocker to abate the side effects. Followup monitoring was conducted in 78% of tamsulosin patients, of whom 55% reported effectiveness of tamsulosin, and 6% reported side effects attributable to tamsulosin. No meaningful differences in prescribing patterns were found between the pregroups and postgroups relative to the posting of the criteria for nonformulary use. Two sites had some form of the criteria made available to physicians, while 4 sites had not implemented the national criteria. Extrapolation of the results to the VA system-wide yielded a conservative estimate of 480,993 dollars in potential cost avoidance for 1 quarter (July to September 2002) when corrected for patients prescribed tamsulosin outside of the criteria for nonformulary use. Despite the availability of national criteria for nonformulary use of tamsulosin, the results reveal that these criteria were not followed by prescribers. The DUE reinforced the need for more effective implementation and dissemination of criteria for appropriate use of tamsulosin. A formal education process is necessary to encourage appropriate use of formulary alpha-blockers and to attenuate the increased cost associated with the inappropriate prescribing of the nonformulary drug. JF - Journal of managed care pharmacy : JMCP AU - Burk, Muriel AU - Furmaga, Elaine AU - Dong, Diane AU - Cunningham, Francesca AD - VA Pharmacy Benefits Management Strategic Healthcare Group, Hines, Illinois 60141, USA. Muriel.Burk@med.va.gov PY - 2004 SP - 423 EP - 432 VL - 10 IS - 5 SN - 1083-4087, 1083-4087 KW - Adrenergic alpha-Antagonists KW - 0 KW - Sulfonamides KW - tamsulosin KW - G3P28OML5I KW - Index Medicus KW - United States KW - Humans KW - Practice Guidelines as Topic KW - Pharmacy Service, Hospital KW - Male KW - Hospitals, Veterans KW - Prostatic Hyperplasia -- drug therapy KW - Adrenergic alpha-Antagonists -- therapeutic use KW - Sulfonamides -- adverse effects KW - Sulfonamides -- therapeutic use KW - Adrenergic alpha-Antagonists -- adverse effects KW - Drug Utilization Review UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66880951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+managed+care+pharmacy+%3A+JMCP&rft.atitle=Multicenter+drug+use+evaluation+of+tamsulosin+and+availability+of+guidance+criteria+for+nonformulary+use+in+the+veterans+affairs+health+system.&rft.au=Burk%2C+Muriel%3BFurmaga%2C+Elaine%3BDong%2C+Diane%3BCunningham%2C+Francesca&rft.aulast=Burk&rft.aufirst=Muriel&rft.date=2004-09-01&rft.volume=10&rft.issue=5&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Journal+of+managed+care+pharmacy+%3A+JMCP&rft.issn=10834087&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-10-26 N1 - Date created - 2004-09-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: J Manag Care Pharm. 2004 Sep-Oct;10(5):456-60 [15369430] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The febrile patient: diagnostic, prognostic and therapeutic considerations. AN - 66855783; 15353288 AB - Although clinicians have long pondered the diagnostic and prognostic implications and the treatment of fever, fundamental questions remain unanswered. The value of the height or pattern of a fever in predicting the etiology or course of the illness causing it is a case in point. Whether fever is ever harmful and should, therefore, be suppressed is another. These controversies and others concerning the febrile patient are the subject of this manuscript. JF - Frontiers in bioscience : a journal and virtual library AU - Mackowiak, Philip A AD - Medical Care Clinical Center, VA Maryland Health Care System, Baltimore, MD 21201, USA. Philip.Mackowiak@med.va.gov Y1 - 2004/09/01/ PY - 2004 DA - 2004 Sep 01 SP - 2297 EP - 2301 VL - 9 SN - 1093-9946, 1093-9946 KW - Analgesics, Non-Narcotic KW - 0 KW - Index Medicus KW - Body Temperature Regulation KW - Analgesics, Non-Narcotic -- adverse effects KW - Analgesics, Non-Narcotic -- pharmacology KW - Sepsis -- pathology KW - Diagnosis, Differential KW - Body Temperature KW - Humans KW - Prognosis KW - Fever -- diagnosis KW - Fever -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66855783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+bioscience+%3A+a+journal+and+virtual+library&rft.atitle=The+febrile+patient%3A+diagnostic%2C+prognostic+and+therapeutic+considerations.&rft.au=Mackowiak%2C+Philip+A&rft.aulast=Mackowiak&rft.aufirst=Philip&rft.date=2004-09-01&rft.volume=9&rft.issue=&rft.spage=2297&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+bioscience+%3A+a+journal+and+virtual+library&rft.issn=10939946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-28 N1 - Date created - 2004-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Health and Health Status of Older Korean Americans at the 100-Year Anniversary of Korean Immigration AN - 60532800; 200502528 AB - There are 28 subgroups in the Asian American Pacific Islander (AAPI) ethnic population. They accounted for 12.5 million persons in the year 2002 or 4.4% of the non-institutionalized US population (Reeves & Bennett, 2003). It is a rapidly growing population in the US, particularly in Southern CA. The Korean American population is the fifth largest ethnic group in the heterogeneous AAPI population. Despite their increasing numbers there lacks data regarding the health status & healthcare utilization of the AAPI population. The aim of this study is to characterize the health status & healthcare utilization of an Asian American ethnic group, the Korean Americans. The data are from the 2000 Korean American Health Survey (KAHS). This survey of 1,660 Korean Americans living in Los Angeles County assessed their health status & medical needs & composed the largest sample recruited for a health study on Korean Americans to date. For the study 208 Koreans Americans aged 65 & over were reported. Descriptive statistics were performed to illustrate the health status & needs of the Korean American older persons. Over one-half of the sample, 69% of the Korean American older persons in the study reported a fair or poor health status. This is in stark contrast to a survey conducted by the Commonwealth Fund, which found that 17% of the minorities & 30% of the Korean Americans rated their health as fair or poor (Commonwealth Fund, 2002). With regards to access to healthcare 21% of the Korean American older adults in the sample lacked health insurance & 31% had never visited a medical doctor within the last 12 months for a check up or consultation. It is felt that an individual's chance of being uninsured varies across the life span & that people 65 years & older have a minimal likelihood of being uninsured due to Medicare (IOM, 2001). However when looking at certain subgroups higher percentages of uninsured are revealed. One out of every three Koreans Americans in the US is uninsured compared to 21% of all AAPI & 14% non-Latino whites. In CA the proportion is even higher with almost half of all Koreans being uninsured (Brown et al. 2001). This type of discrepancy compounds the "Model Minority Myth" that AAPI population is a successful minority group & do not have barriers to health care (Chen et al. 1995). One study examining health services research status in the AAPI found that Korean Americans were one of the most understudied populations relative to their size (Andersen et al. 1995). Since the AAPI population & subgroups are often not included in health services research this results in "myths" or inaccuracies regarding their health. Studies of AAPI populations are needed to provide information regarding the health of the population, educate health care providers to assist them in the care of ethnic populations, & seek interventions to remove health disparities in minority populations. 2 Tables, 34 References. Adapted from the source document. JF - Journal of Cross-Cultural Gerontology AU - Sohn, Linda AD - VA GLAHS, Los Angeles, CA linda.sohn@med.va.gov Y1 - 2004/09// PY - 2004 DA - September 2004 SP - 203 EP - 219 VL - 19 IS - 3 SN - 0169-3816, 0169-3816 KW - Health Insurance KW - Immigrants KW - Elderly KW - United States of America KW - Asian Americans KW - Health KW - Health Care Utilization KW - article KW - 2143: social problems and social welfare; social gerontology KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60532800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cross-Cultural+Gerontology&rft.atitle=The+Health+and+Health+Status+of+Older+Korean+Americans+at+the+100-Year+Anniversary+of+Korean+Immigration&rft.au=Sohn%2C+Linda&rft.aulast=Sohn&rft.aufirst=Linda&rft.date=2004-09-01&rft.volume=19&rft.issue=3&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cross-Cultural+Gerontology&rft.issn=01693816&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Number of references - 34 N1 - Last updated - 2016-09-28 N1 - CODEN - JCCGEB N1 - SubjectsTermNotLitGenreText - Elderly; Asian Americans; United States of America; Immigrants; Health; Health Care Utilization; Health Insurance ER - TY - JOUR T1 - Neutrophil NADPH Oxidase Is Reduced at the Anaplasma phagocytophilum Phagosome AN - 18056265; 5992135 AB - The intracellular organism Anaplasma phagocytophilum causes human granulocytic ehrlichiosis and specifically infects and multiplies in neutrophilic granulocytes. Previous reports have suggested that, for its survival, this bacterium suppresses the neutrophil respiratory burst. To investigate the mechanism of survival, we first assessed the kinetics of A. phagocytophilum entry into neutrophils by using double-labeling confocal microscopy. At 30, 60, 120, and 240 min of incubation, 25, 50, 55, and 70% of neutrophils contained bacteria, respectively. The neutrophil respiratory burst in the presence of A. phagocytophilum was assessed by a kinetic cytochrome c assay and by measurement of oxygen consumption. Neutrophils in the presence of A. phagocytophilum did not produce a significant respiratory burst, but A. phagocytophilum did not inhibit the neutrophil respiratory burst when phorbol myristate acetate was added. Immunoelectron microscopy of neutrophils infected with A. phagocytophilum or Escherichia coli revealed that NADPH oxidase subunits gp91 super(phox) and p22 super(phox) were significantly reduced at the A. phagocytophilum phagosome after 1 and 4 h of incubation. In neutrophils incubated simultaneously with A. phagocytophilum and E. coli for 30, 60, and 90 min, gp91 super(phox) was present on 20, 14, and 10% of the A. phagocytophilum phagosomes, whereas p22 super(phox) was present in 11, 5, and 4% of the phagosomes, respectively. Similarly, on E. coli phagosomes, gp91 super(phox) was present in 62, 64, and 65%, whereas p22 super(phox) was detected in 54, 48, and 48%. We conclude that A. phagocytophilum does not suppress a global respiratory burst and that, under identical conditions in the same cells, A. phagocytophilum, but not E. coli, significantly reduces gp91 super(phox) and p22 super(phox) from its phagosome membrane. JF - Infection and Immunity AU - Ijdo, Jacob W AU - Mueller, Angel C AD - Inflammation Program, Department of Internal Medicine, Division of Rheumatology, University of Iowa, and Veterans Administration Medical Center, Iowa City, Iowa Y1 - 2004/09// PY - 2004 DA - Sep 2004 SP - 5392 EP - 5401 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 72 IS - 9 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Phagosomes KW - Immunoelectron microscopy KW - Infection KW - Anaplasma KW - Respiratory burst KW - Pyruvic acid KW - Cytochrome c KW - Escherichia coli KW - NADPH oxidase KW - Oxygen consumption KW - Bacteria KW - Leukocytes (neutrophilic) KW - Immunity KW - Acetic acid KW - Leukocytes (granulocytic) KW - Confocal microscopy KW - Human granulocytic ehrlichiosis KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18056265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Neutrophil+NADPH+Oxidase+Is+Reduced+at+the+Anaplasma+phagocytophilum+Phagosome&rft.au=Ijdo%2C+Jacob+W%3BMueller%2C+Angel+C&rft.aulast=Ijdo&rft.aufirst=Jacob&rft.date=2004-09-01&rft.volume=72&rft.issue=9&rft.spage=5392&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Anaplasma; Escherichia coli; Leukocytes (neutrophilic); Phagosomes; Respiratory burst; NADPH oxidase; Immunity; Acetic acid; Confocal microscopy; Cytochrome c; Oxygen consumption; Leukocytes (granulocytic); Immunoelectron microscopy; Human granulocytic ehrlichiosis; Infection; Pyruvic acid; Bacteria ER - TY - JOUR T1 - Hepatotoxicity of rifampin and pyrazinamide in the treatment of latent tuberculosis infection in HIV-infected persons: is it different than in HIV-uninfected persons? AN - 66856454; 15356822 AB - In 2000, results of a multinational trial demonstrated that a 2-month course of rifampin and pyrazinamide (RZ) was as effective as isoniazid (INH) in reducing tuberculosis in human immunodeficiency virus (HIV)-infected individuals with latent tuberculosis infection (LTBI). After the release of new guidelines, the Centers for Disease Control and Prevention received reports of severe hepatotoxicity associated with the use of the RZ regimen for the treatment of LTBI in the general population. To better understand the occurrence of hepatotoxicity in an HIV-infected population, we conducted a more detailed analysis of the liver function test results obtained in the multinational trial of RZ. At study entry, patients were required to have a bilirubin level of < or =2.5 mg/dL and both an aspartate aminotransferase (AST) level and an alkaline phosphatase level of < or =5 times the upper limit of normal. Patients with acute hepatitis were excluded. At months 1 and 2 of the study, all patients had bilirubin and AST levels measured. There was no difference between the RZ and INH groups with regard to AST level or bilirubin level at baseline. An increase in the AST level of > or =40 U/L was associated with the use of INH and older age; and an increase in the bilirubin level of > or =0.5 mg/dL was associated with the use of RZ, male sex, and nonwhite race (P250 U/L occurred in 12 of 745 INH recipients and in 15 of 721 RZ recipients (P=.56), and an absolute bilirubin level of >2.5 mg/dL occurred in 5 of 743 INH recipients and 13 of 718 RZ recipients (P=.06). These data demonstrate very little liver injury associated with either INH or RZ in the HIV-infected subjects, leaving unclear the reasons for serious RZ-related liver damage in the general population. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Gordin, Fred M AU - Cohn, David L AU - Matts, John P AU - Chaisson, Richard E AU - O'Brien, Richard J AU - Terry Beirn Community Programs for Clinical Research on AIDS AU - Adult AIDS Clinical Trials Group AU - Centers for Disease Control and Prevention AD - Infectious Diseases Section, Veterans Affairs Medical Center and George Washington University, Washington, DC 20422, USA. Fred.Gordin@med.va.gov ; Terry Beirn Community Programs for Clinical Research on AIDS ; Adult AIDS Clinical Trials Group ; Centers for Disease Control and Prevention Y1 - 2004/08/15/ PY - 2004 DA - 2004 Aug 15 SP - 561 EP - 565 VL - 39 IS - 4 KW - Pyrazinamide KW - 2KNI5N06TI KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Bilirubin KW - RFM9X3LJ49 KW - Isoniazid KW - V83O1VOZ8L KW - Rifampin KW - VJT6J7R4TR KW - Index Medicus KW - Regression Analysis KW - Multicenter Studies as Topic KW - Randomized Controlled Trials as Topic KW - Drug Administration Schedule KW - Isoniazid -- therapeutic use KW - Humans KW - Isoniazid -- adverse effects KW - Multivariate Analysis KW - Aspartate Aminotransferases -- blood KW - Liver -- drug effects KW - Adult KW - Bilirubin -- blood KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Chemical and Drug Induced Liver Injury -- blood KW - Tuberculosis -- blood KW - Pyrazinamide -- adverse effects KW - Chemical and Drug Induced Liver Injury -- etiology KW - Pyrazinamide -- therapeutic use KW - Tuberculosis -- drug therapy KW - Tuberculosis -- complications KW - HIV Infections -- complications KW - HIV Infections -- blood KW - Rifampin -- adverse effects KW - HIV Infections -- drug therapy KW - Rifampin -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66856454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Hepatotoxicity+of+rifampin+and+pyrazinamide+in+the+treatment+of+latent+tuberculosis+infection+in+HIV-infected+persons%3A+is+it+different+than+in+HIV-uninfected+persons%3F&rft.au=Gordin%2C+Fred+M%3BCohn%2C+David+L%3BMatts%2C+John+P%3BChaisson%2C+Richard+E%3BO%27Brien%2C+Richard+J%3BTerry+Beirn+Community+Programs+for+Clinical+Research+on+AIDS%3BAdult+AIDS+Clinical+Trials+Group%3BCenters+for+Disease+Control+and+Prevention&rft.aulast=Gordin&rft.aufirst=Fred&rft.date=2004-08-15&rft.volume=39&rft.issue=4&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-31 N1 - Date created - 2004-09-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Infect Dis. 2004 Aug 15;39(4):566-8 [15356823] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metformin monitoring and change in serum creatinine levels in patients undergoing radiologic procedures involving administration of intravenous contrast media. AN - 66836078; 15338847 AB - To evaluate the prevalence and magnitude of serum creatinine level elevations in patients receiving metformin who underwent radiologic procedures involving administration of intravenous contrast media, and to evaluate the efficacy of an electronic consultation in promoting timely evaluation of renal function after the procedure. Retrospective evaluation. Veterans Affairs Medical Center. Ninety-seven patients receiving metformin who underwent a radiologic procedure involving administration of intravenous contrast media over a 27-month period. Ninety-seven patients underwent a total of 111 radiologic procedures with documented administration of intravenous contrast dye. Average time from procedure to laboratory follow-up, excluding one patient, was 2.62+/-1.56 days. Average serum creatinine levels before and after the procedure were 1.10+/-0.19 and 1.13+/-0.23 mg/dl, respectively (p>0.05). Four patients developed contrast material-associated nephropathy. An additional four patients with borderline serum creatinine levels at baseline (1.4 mg/dl) had a serum creatinine level of 1.5 mg/dl or greater after the procedure. Our results indicated that electronic consultations result in timely evaluation of serum creatinine levels in patients receiving metformin who undergo a radiologic procedure involving intravenous contrast material. Also, the study suggests that nearly 4% of patients with diabetes mellitus and normal renal function may develop contrast material-associated nephropathy [corrected] with nonionic contrast material. In addition, about 8% of patients with diabetes treated with metformin (with baseline serum creatinine levels or = 1.5 mg/dl) of lactic acidosis. These findings support the recommendations of the Food and Drug Administration regarding metformin monitoring in patients undergoing radiologic procedures involving administration of intravenous contrast media. JF - Pharmacotherapy AU - Parra, David AU - Legreid, Anna M AU - Beckey, Nick P AU - Reyes, Sonia AD - Section of Clinical Pharmacy, Patient Support Service, Department of Veterans Affairs Medical Center, West Palm Beach, FL 33410-6400, USA. David.Parra@med.va.gov Y1 - 2004/08// PY - 2004 DA - August 2004 SP - 987 EP - 993 VL - 24 IS - 8 SN - 0277-0008, 0277-0008 KW - Contrast Media KW - 0 KW - Hypoglycemic Agents KW - Metformin KW - 9100L32L2N KW - Creatinine KW - AYI8EX34EU KW - Index Medicus KW - Injections, Intravenous KW - Humans KW - Retrospective Studies KW - Aged KW - Radiography KW - Male KW - Hospitals, Veterans KW - Metformin -- therapeutic use KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Contrast Media -- adverse effects KW - Hypoglycemic Agents -- therapeutic use KW - Metformin -- contraindications KW - Diabetic Nephropathies -- chemically induced KW - Hypoglycemic Agents -- contraindications KW - Contrast Media -- administration & dosage KW - Creatinine -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66836078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Metformin+monitoring+and+change+in+serum+creatinine+levels+in+patients+undergoing+radiologic+procedures+involving+administration+of+intravenous+contrast+media.&rft.au=Parra%2C+David%3BLegreid%2C+Anna+M%3BBeckey%2C+Nick+P%3BReyes%2C+Sonia&rft.aulast=Parra&rft.aufirst=David&rft.date=2004-08-01&rft.volume=24&rft.issue=8&rft.spage=987&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-10-26 N1 - Date created - 2004-09-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Pharmacotherapy. 2004 Oct;24(10):1489 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Patterns of dispensed disulfiram and naltrexone for alcoholism treatment in a veteran patient population. AN - 66798412; 15318122 AB - Short-term treatment trials indicate that two Food and Drug Administration-approved agents, disulfiram and naltrexone, may each curtail alcohol consumption, but two large 1-year Veterans Administration cooperative studies showed no long-term benefits for these agents over placebo. To assess whether these agents are being prescribed for extended periods, as an indicator of long-term use in nonexperimental settings, we compared dispensing patterns in a veteran patient population. The New England Veterans Integrated Service Network outpatient pharmacy files between January 1, 1998, and June 30, 2001, were analyzed; only patients with prescriptions on or after March 1, 1998, were included. Measurements for each patient included data on new and refilled prescriptions of disulfiram, naltrexone, and control medications. Prescription survival curves with right censoring were constructed. Distinct treatment episodes were defined by having six or more months between the end date of a prior prescription and the start date of a new prescription. From eight New England Veterans Integrated Service Network centers, 754 patients were dispensed disulfiram, and 971 were dispensed naltrexone, encompassing 873 and 1075 treatment episodes, respectively. Treatment episode durations were virtually identical for both drugs: more than 35% of episodes were 1 month or shorter, more than 50% were 2 months or shorter, and 75% were 5 months or shorter. Concurrently prescribed neuroleptic or statin medications predicted longer disulfiram and naltrexone treatment episodes. However, for patients newly prescribed common neuroleptic, antidepressant, or statin agents, the risks for discontinuing disulfiram or naltrexone were 1.4 to 2.3 times greater than for discontinuing these other agents. In clinical settings, veteran patients were likely to be dispensed either disulfiram or naltrexone for only several months or less. The contexts and reasons for these predominantly short-term treatment episodes or the benefits derived were not known and merit further study. Copyright 2004 Research Society on Alcoholism JF - Alcoholism, clinical and experimental research AU - Hermos, John A AU - Young, Melissa M AU - Gagnon, David R AU - Fiore, Louis D AD - Pharmacoepidemiology Research Project, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Veterans Affairs Boston Healthcare System, Boston, Massachusetts 02130, USA. john.hermos@med.va.gov Y1 - 2004/08// PY - 2004 DA - August 2004 SP - 1229 EP - 1235 VL - 28 IS - 8 SN - 0145-6008, 0145-6008 KW - Naltrexone KW - 5S6W795CQM KW - Disulfiram KW - TR3MLJ1UAI KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Adult KW - Confidence Intervals KW - Aged KW - Middle Aged KW - New England -- epidemiology KW - Survival Analysis KW - Multivariate Analysis KW - Disulfiram -- therapeutic use KW - Veterans -- statistics & numerical data KW - Alcoholism -- epidemiology KW - Alcoholism -- drug therapy KW - Naltrexone -- therapeutic use KW - Drug Prescriptions -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66798412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Patterns+of+dispensed+disulfiram+and+naltrexone+for+alcoholism+treatment+in+a+veteran+patient+population.&rft.au=Hermos%2C+John+A%3BYoung%2C+Melissa+M%3BGagnon%2C+David+R%3BFiore%2C+Louis+D&rft.aulast=Hermos&rft.aufirst=John&rft.date=2004-08-01&rft.volume=28&rft.issue=8&rft.spage=1229&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-02-04 N1 - Date created - 2004-08-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Using narrative text and coded data to develop hazard scenarios for occupational injury interventions. AN - 66790261; 15314055 AB - To determine whether narrative text in safety reports contains sufficient information regarding contributing factors and precipitating mechanisms to prioritize occupational back injury prevention strategies.Design, setting, subjects, and Nine essential data elements were identified in narratives and coded sections of safety reports for each of 94 cases of back injuries to United States Army truck drivers reported to the United States Army Safety Center between 1987 and 1997. The essential elements of each case were used to reconstruct standardized event sequences. A taxonomy of the event sequences was then developed to identify common hazard scenarios and opportunities for primary interventions. Coded data typically only identified five data elements (broad activity, task, event/exposure, nature of injury, and outcomes) while narratives provided additional elements (contributing factor, precipitating mechanism, primary source) essential for developing our taxonomy. Three hazard scenarios were associated with back injuries among Army truck drivers accounting for 83% of cases: struck by/against events during motor vehicle crashes; falls resulting from slips/trips or loss of balance; and overexertion from lifting activities. Coded data from safety investigations lacked sufficient information to thoroughly characterize the injury event. However, the combination of existing narrative text (similar to that collected by many injury surveillance systems) and coded data enabled us to develop a more complete taxonomy of injury event characteristics and identify common hazard scenarios. This study demonstrates that narrative text can provide the additional information on contributing factors and precipitating mechanisms needed to target prevention strategies. JF - Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention AU - Lincoln, A E AU - Sorock, G S AU - Courtney, T K AU - Wellman, H M AU - Smith, G S AU - Amoroso, P J AD - War-Related Illness and Injury Study Center, Washington DC Veterans Administration Medical Center, Department of Veterans Affairs, Washington, DC 20422, USA. Andrew.Lincoln@med.va.gov Y1 - 2004/08// PY - 2004 DA - August 2004 SP - 249 EP - 254 VL - 10 IS - 4 SN - 1353-8047, 1353-8047 KW - Index Medicus KW - Information Dissemination -- methods KW - Accidents, Occupational -- prevention & control KW - Data Collection -- methods KW - Risk Factors KW - Military Personnel KW - Humans KW - Safety KW - Accidental Falls -- prevention & control KW - Forms and Records Control KW - Lifting KW - Accidents, Traffic -- prevention & control KW - Male KW - Documentation KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- etiology KW - Back Injuries -- prevention & control KW - Back Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66790261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+prevention+%3A+journal+of+the+International+Society+for+Child+and+Adolescent+Injury+Prevention&rft.atitle=Using+narrative+text+and+coded+data+to+develop+hazard+scenarios+for+occupational+injury+interventions.&rft.au=Lincoln%2C+A+E%3BSorock%2C+G+S%3BCourtney%2C+T+K%3BWellman%2C+H+M%3BSmith%2C+G+S%3BAmoroso%2C+P+J&rft.aulast=Lincoln&rft.aufirst=A&rft.date=2004-08-01&rft.volume=10&rft.issue=4&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Injury+prevention+%3A+journal+of+the+International+Society+for+Child+and+Adolescent+Injury+Prevention&rft.issn=13538047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-02 N1 - Date created - 2004-08-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Prev Med. 2000 Apr;18(3 Suppl):8-13 [10736536] Mil Med. 1999 Aug;164(8 Suppl):1-88 [10847822] Mil Med. 1999 Aug;164(8 Suppl):1-36 [10847819] J Nippon Med Sch. 2000 Jun;67(3):186-90 [10851352] Work. 2002;19(1):95-102 [12454355] Am J Ind Med. 1998 Aug;34(2):133-6 [9651622] Inj Prev. 2004 Aug;10(4):206-11 [15314046] Hum Factors. 1983 Jun;25(3):329-42 [6885081] Scand J Work Environ Health. 1991 Oct;17(5):302-11 [1947915] Am J Ind Med. 1997 Aug;32(2):116-28 [9215434] Accid Anal Prev. 2004 Mar;36(2):165-71 [14642871] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gulf War veterans' illnesses: a pilot study of the relationship of illness beliefs to symptom severity and functional health status. AN - 66773150; 15300134 AB - This investigation describes the illness beliefs of veterans regarding their Gulf War-related health concerns and investigates the relationship of these illness beliefs to physical and mental health functioning. Gulf War veterans (N = 583) presenting for evaluation at a Veteran's Affairs and Department of Defense facility completed self-report measures of symptom-related beliefs, psychosocial distress, and functional status. Hierarchical multiple regression analyses were performed to determine the extent that symptom-related beliefs impacted symptom-reporting and functional status independent of demographic factors and psychiatric illness. Several beliefs predicted physical symptom reporting and functional impairment in physical health and mental health domains after controlling for demographic variables and psychiatric illness. Gulf War veterans' illness beliefs may impact clinical outcomes. Discussing illness beliefs and providing accurate information is an important component of medical care for Gulf War veterans. JF - Journal of occupational and environmental medicine AU - Hunt, Stephen C AU - Richardson, Ralph D AU - Engel, Charles C AU - Atkins, David C AU - McFall, Miles AD - Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA. stephen.hunt@med.va.gov Y1 - 2004/08// PY - 2004 DA - August 2004 SP - 818 EP - 827 VL - 46 IS - 8 SN - 1076-2752, 1076-2752 KW - Index Medicus KW - Regression Analysis KW - Health Status Indicators KW - Humans KW - Health Status KW - Adult KW - Pilot Projects KW - Middle Aged KW - Mental Health KW - Attitude KW - Male KW - Female KW - Persian Gulf Syndrome -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66773150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Gulf+War+veterans%27+illnesses%3A+a+pilot+study+of+the+relationship+of+illness+beliefs+to+symptom+severity+and+functional+health+status.&rft.au=Hunt%2C+Stephen+C%3BRichardson%2C+Ralph+D%3BEngel%2C+Charles+C%3BAtkins%2C+David+C%3BMcFall%2C+Miles&rft.aulast=Hunt&rft.aufirst=Stephen&rft.date=2004-08-01&rft.volume=46&rft.issue=8&rft.spage=818&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-01 N1 - Date created - 2004-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Concurrent psychiatric diagnoses by age and race among persons with bipolar disorder. AN - 66753193; 15292544 AB - The authors characterized concurrent psychiatric diagnoses among patients with a diagnosis of bipolar disorder who were in routine care by using administrative data from a Department of Veterans Affairs facility. Of 813 patients who had a diagnosis of bipolar disorder in 2000, 21 percent were older (>/=60 years) whites, and 2 percent were older African Americans. Older African Americans were the most likely to have a diagnosis of schizophrenia documented in the medical record compared with younger African Americans, older whites, and younger whites (67 percent, 34 percent, 38 percent, and 27 percent, respectively). The results suggest that older African-American patients with bipolar disorder are more likely to receive diagnoses of mutually exclusive conditions, such as schizophrenia, and thus appear to have an elevated risk of their illness being underrecognized or misdiagnosed and receiving inappropriate treatment. JF - Psychiatric services (Washington, D.C.) AU - Kilbourne, Amy M AU - Haas, Gretchen L AU - Mulsant, Benoit H AU - Bauer, Mark S AU - Pincus, Harold A AD - Center for Health Equity Research and Promotion, the Department of Veterans Affairs (VA) Pittsburgh Healthcare System, Pennsylvania 15240, USA. amy.kilbourne@med.va.gov Y1 - 2004/08// PY - 2004 DA - August 2004 SP - 931 EP - 933 VL - 55 IS - 8 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - International Classification of Diseases KW - Humans KW - Aged KW - Middle Aged KW - Diagnostic and Statistical Manual of Mental Disorders KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Bipolar Disorder -- diagnosis KW - Bipolar Disorder -- epidemiology KW - Stress Disorders, Post-Traumatic -- therapy KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Alcoholism -- therapy KW - Schizophrenia -- diagnosis KW - Bipolar Disorder -- therapy KW - Schizophrenia -- therapy KW - Schizophrenia -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66753193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Concurrent+psychiatric+diagnoses+by+age+and+race+among+persons+with+bipolar+disorder.&rft.au=Kilbourne%2C+Amy+M%3BHaas%2C+Gretchen+L%3BMulsant%2C+Benoit+H%3BBauer%2C+Mark+S%3BPincus%2C+Harold+A&rft.aulast=Kilbourne&rft.aufirst=Amy&rft.date=2004-08-01&rft.volume=55&rft.issue=8&rft.spage=931&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-01 N1 - Date created - 2004-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of the outpatient clinic nurse in monitoring opioid therapy. AN - 66668694; 15228887 AB - Outpatient clinical nurses specialize in patient care in a particular area of nursing practice. Typically, the registered nurse also holds a professional certification in that specialty or subspecialty. The only nursing certification related to pain and symptom management is the Hospice and Palliative Care certification. Managing the patient with chronic pain is a common clinical challenge, especially when opioid therapy is indicated. Chronic pain often is undertreated in patients with cancer and in those with non-malignant conditions. Because chronic pain can be complex, successful long-term treatment is more difficult for providers. Professional nurses are the primary team members who assess, coordinate, direct, and evaluate patient care needs during times of illness. A nurse is one of the first contacts in the health care system that the patient encounters. Nurses must possess unique qualifications and be able to deal compassionately with a demanding and sometimes hostile group of patients. How the patients are accepted into a pain medicine practice and managed is discussed in this article. JF - Current pain and headache reports AU - Jennings, Pamela J AD - George E. Wahlen Department of Veterans Affairs Medical Center, 500 Foothill Boulevard, Salt Lake City, UT 84148, USA. Pamela.Jennings@med.va.gov Y1 - 2004/08// PY - 2004 DA - August 2004 SP - 284 EP - 288 VL - 8 IS - 4 SN - 1531-3433, 1531-3433 KW - Analgesics, Opioid KW - 0 KW - Index Medicus KW - Humans KW - Adult KW - Substance-Related Disorders -- complications KW - Chronic Disease KW - Male KW - Substance-Related Disorders -- prevention & control KW - Pain -- complications KW - Ambulatory Care -- organization & administration KW - Pain -- drug therapy KW - Nurse's Role KW - Pain -- nursing KW - Analgesics, Opioid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66668694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+pain+and+headache+reports&rft.atitle=The+role+of+the+outpatient+clinic+nurse+in+monitoring+opioid+therapy.&rft.au=Jennings%2C+Pamela+J&rft.aulast=Jennings&rft.aufirst=Pamela&rft.date=2004-08-01&rft.volume=8&rft.issue=4&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Current+pain+and+headache+reports&rft.issn=15313433&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-11-08 N1 - Date created - 2004-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risks, Stigma and Honduran Garifuna Conceptions of HIV/AIDS AN - 60566993; 200502530 AB - The HIV/AIDS epidemic along Honduras' north coast has intensified in recent years & become particularly severe in Garifuna communities. Based on a qualitative study in the community of Las Espinas & comparison with results from an earlier knowledge, attitudes, beliefs, & practices survey, this article explores Garifuna ideas about the disease, focusing on issues of risk perception & stigma. Using correspondence analysis with data from systematic elicitation techniques we abstract the local schema of HIV/AIDS, showing how accurate knowledge of transmission co-occurs with cultural judgments about safe partners, increasing chances for infection. Despite broad familiarity with the disease in the community it remains highly stigmatized, suggesting continuing problems in coming to terms with the epidemic as treatment becomes more widely available in Honduras. Questions of power, sexuality, & affective expectations about partners complicate the situation for women hoping to prevent infection. Given the broader risk environment characterized by labor migration & transnational movement, vital interventions & educational efforts in Garifuna communities will need to be complemented with prevention efforts in contexts where men make a living. 3 Tables, 1 Figure, 58 References. [Copyright 2004 Elsevier Ltd.] JF - Social Science & Medicine AU - Stansbury, James P AU - Sierra, Manuel AD - Rehabilitation Outcomes Research Center, North Florida/South Georgia Veterans Health System, Gainesville, FL James.stansbury2@med.va.gov Y1 - 2004/08// PY - 2004 DA - August 2004 SP - 457 EP - 471 VL - 59 IS - 3 SN - 0277-9536, 0277-9536 KW - Acquired Immune Deficiency Syndrome KW - Cultural Values KW - Intervention KW - Labor Migration KW - Health Policy KW - Health Education KW - Treatment KW - Stigma KW - Risk KW - Honduras KW - Sex Information KW - Sex Role Attitudes KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60566993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Risks%2C+Stigma+and+Honduran+Garifuna+Conceptions+of+HIV%2FAIDS&rft.au=Stansbury%2C+James+P%3BSierra%2C+Manuel&rft.aulast=Stansbury&rft.aufirst=James&rft.date=2004-08-01&rft.volume=59&rft.issue=3&rft.spage=457&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2003.11.013 LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Number of references - 58 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Honduras; Acquired Immune Deficiency Syndrome; Risk; Stigma; Health Education; Sex Information; Sex Role Attitudes; Cultural Values; Treatment; Labor Migration; Health Policy; Intervention DO - http://dx.doi.org/10.1016/j.socscimed.2003.11.013 ER - TY - JOUR T1 - Delayed Detection of Ventricular Tachycardia in a Dual Chamber Rate Adaptive Pacing Implantable Cardioverter Defibrillator: A Case of Intradevice Interaction AN - 19961370; 6623894 AB - Ventricular tachycardia detection is delayed due to concomitant programming of rate adaptive dual chamber pacing. Underlying timing cycle constraints as well as programming precautions and pitfalls are reviewed. JF - Pacing and Clinical Electrophysiology AU - Shalaby, Alaa A AD - Address for reprints: Alaa A. Shalaby, M.D., F.A.C.C., Assistant Professor of Medicine, University of Pittsburgh, Director of Cardiac Electrophysiology, Division of Cardiology, Pittsburgh VA Healthcare System 111[copy ]) University Drive C, Pittsburgh PA 15240, Alaa.Shalaby@med.va.gov Y1 - 2004/08// PY - 2004 DA - Aug 2004 SP - 1164 EP - 1166 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 27 IS - 8 SN - 0147-8389, 0147-8389 KW - Biotechnology and Bioengineering Abstracts KW - Tachycardia KW - Reviews KW - Defibrillators KW - Electrophysiology KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19961370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pacing+and+Clinical+Electrophysiology&rft.atitle=Delayed+Detection+of+Ventricular+Tachycardia+in+a+Dual+Chamber+Rate+Adaptive+Pacing+Implantable+Cardioverter+Defibrillator%3A+A+Case+of+Intradevice+Interaction&rft.au=Shalaby%2C+Alaa+A&rft.aulast=Shalaby&rft.aufirst=Alaa&rft.date=2004-08-01&rft.volume=27&rft.issue=8&rft.spage=1164&rft.isbn=&rft.btitle=&rft.title=Pacing+and+Clinical+Electrophysiology&rft.issn=01478389&rft_id=info:doi/10.1111%2Fj.1540-8159.2004.00603.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - SuppNotes - Figures, 1; references, 5. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Defibrillators; Reviews; Tachycardia; Electrophysiology DO - http://dx.doi.org/10.1111/j.1540-8159.2004.00603.x ER - TY - JOUR T1 - Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2 AN - 19898795; 5963569 AB - The expression of inducible antimicrobial peptides, such as human beta - defensin-2 (HBD-2) by epithelia, comprises a component of innate pulmonary defenses. We hypothesized that HBD-2 induction in airway epithelia is linked to pattern recognition receptors such as the Toll-like receptors (TLRs). We found that primary cultures of well-differentiated human airway epithelia express the mRNA for TLR-4, but little or no MD-2 mRNA, and display little HBD-2 expression in response to treatment with purified endotoxin +/- LPS binding protein (LBP) and soluble CD14. Expression of endogenous MD-2 by transduction of airway epithelial cells with an adenoviral vector encoding MD-2 or extracellular addition of recombinant MD-2 both increased the responses of airway epithelia to endotoxin + LBP and sCD14 by >100-fold, as measured by NF- Kappa B-luciferase activity and HBD-2 mRNA expression. MD-2 mRNA could be induced in airway epithelia by exposure of these cells to specific bacterial or host products (e.g., killed Haemophilus influenzae, the P6 outer membrane protein from H. influenzae, or TNF- alpha + IFN- gamma ). These findings suggest that MD-2, either coexpressed with TLR-4 or secreted when produced in excess of TLR-4 from neighboring cells, is required for airway epithelia to respond sensitively to endotoxin. The regulation of MD-2 expression in airway epithelia and pulmonary macrophages may serve as a means to modify endotoxin responsiveness in the airway. JF - American Journal of Physiology: Lung Cellular and Molecular Physiology AU - Jia, Hong Peng AU - Kline, Joel N AU - Penisten, Andrea AU - Apicella, Michael A AU - Gioannini, Theresa L AU - Weiss, Jerrold AU - Mccray, Paul B AD - Departments of Pediatrics, Internal Medicine, Microbiology, Biochemistry, and The Inflammation Program, Carver College of Medicine, University of Iowa and Iowa City Veterans Administration, Iowa City, Iowa Y1 - 2004/08// PY - 2004 DA - Aug 2004 SP - L428 EP - L437 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA, [mailto:webmaster@the-aps.org], [URL:http://www.the-aps.org/] VL - 287 IS - 2 SN - 1040-0605, 1040-0605 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Endotoxins KW - Macrophages KW - gamma -Interferon KW - Epithelial cells KW - Haemophilus influenzae KW - outer membrane proteins KW - Cell culture KW - CD14 antigen KW - Expression vectors KW - Gene expression KW - Pattern recognition KW - Defensins KW - Lung KW - Lipopolysaccharides KW - Tumor necrosis factor- alpha KW - Antimicrobial peptides KW - Toll-like receptors KW - Respiratory tract KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19898795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.atitle=Endotoxin+responsiveness+of+human+airway+epithelia+is+limited+by+low+expression+of+MD-2&rft.au=Jia%2C+Hong+Peng%3BKline%2C+Joel+N%3BPenisten%2C+Andrea%3BApicella%2C+Michael+A%3BGioannini%2C+Theresa+L%3BWeiss%2C+Jerrold%3BMccray%2C+Paul+B&rft.aulast=Jia&rft.aufirst=Hong&rft.date=2004-08-01&rft.volume=287&rft.issue=2&rft.spage=L428&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.issn=10400605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Macrophages; Endotoxins; Epithelial cells; gamma -Interferon; outer membrane proteins; Cell culture; CD14 antigen; Gene expression; Expression vectors; Pattern recognition; Defensins; Lung; Lipopolysaccharides; Tumor necrosis factor- alpha; Antimicrobial peptides; Toll-like receptors; Respiratory tract; Haemophilus influenzae ER - TY - JOUR T1 - The effect of cane use on the compensatory step following posterior perturbations AN - 18029515; 5984287 AB - Objective. The compensatory step is a critical component of the balance response and is impaired in older fallers. The purpose of this research was to examine whether utilization of a cane modified the compensatory step response following external posterior perturbations. Design. Single subject withdrawal design was employed. Single subject statistical analysis--the standard deviation bandwidth-method--supplemented visual analysis of the data. Methods. Four older adults (range: 73-83 years) with balance impairment who habitually use a cane completed this study. Subjects received a series of sudden backward pulls that were large enough to elicit compensatory stepping. We examined the following variables both with and without cane use: timing of cane loading relative to step initiation and center of mass acceleration, stability margin, center of mass excursion and velocity, step length and width. Results. No participant loaded the cane prior to initiation of the first compensatory step. There was no effect of cane use on the stability margin, nor was there an effect of cane use on center of mass excursion or velocity, or step length or width. Conclusions. These data suggest that cane use does not necessarily improve balance recovery following an external posterior perturbation when the individual is forced to rely on compensatory stepping. Instead these data suggest that the strongest factor in modifying step characteristics is experience with the perturbation. JF - Clinical Biomechanics AU - Hall, C D AU - Jensen, J L AD - Atlanta Veterans Administration, Rehabilitation Research and Development Center (151R), 1670 Clairmont Road, Decatur, GA 30033, USA, chall7@emory.edu Y1 - 2004/08// PY - 2004 DA - Aug 2004 SP - 678 EP - 687 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 19 IS - 7 SN - 0268-0033, 0268-0033 KW - Physical Education Index KW - Stepping KW - Gerontology KW - Balance KW - Biomechanics KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18029515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Biomechanics&rft.atitle=The+effect+of+cane+use+on+the+compensatory+step+following+posterior+perturbations&rft.au=Hall%2C+C+D%3BJensen%2C+J+L&rft.aulast=Hall&rft.aufirst=C&rft.date=2004-08-01&rft.volume=19&rft.issue=7&rft.spage=678&rft.isbn=&rft.btitle=&rft.title=Clinical+Biomechanics&rft.issn=02680033&rft_id=info:doi/10.1016%2Fj.clinbiomech.2004.05.002 LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Biomechanics; Balance; Gerontology; Stepping DO - http://dx.doi.org/10.1016/j.clinbiomech.2004.05.002 ER - TY - JOUR T1 - Enteropathogenic Escherichia coli infection leads to appearance of aberrant tight junctions strands in the lateral membrane of intestinal epithelial cells AN - 18018705; 5967056 AB - Infection of intestinal epithelial cells with enteropathogenic Escherichia coli (EPEC) disrupts tight junction (TJ) architecture and barrier function. The aim of this study was to determine the impact of EPEC on TJ protein interactions and localization. Human intestinal epithelial cells (T84) were infected for 1, 3 or 6 h with EPEC. To probe the TJ protein-protein interactions, co-immunoprecipitations were performed. The associations between ZO-1, occludin and claudin-1 progressively decreased after infection. Corresponding morphological changes were analysed by immunofluorescence confocal microscopy. Tight junction proteins progressively lost their apically restricted localization. Freeze-fracture electron microscopy revealed the appearance of aberrant strands throughout the lateral membrane that contained claudin-1 and occludin as determined by immunogold labelling. These structural alterations were accompanied by a loss of barrier function. Mutation of the gene encoding EspF, important in the disruption of TJs by EPEC, prevented the disruption of TJs. Tight junction structure normalized following eradication of EPEC with gentamicin and overnight recovery. This is the first demonstration that a microbial pathogen can cause aberrant TJ strands in the lateral membrane of host cells. We speculate that the disruption of integral and cytoplasmic TJ protein interactions following EPEC infection allows TJ strands to form or diffuse into the lateral plasma membrane. JF - Cellular Microbiology AU - Muza-Moons, M M AU - Schneeberger, EE AU - Hecht, G A AD - Department of Medicine, Section of Digestive Diseases and Nutrition, and Department of Microbiology and Immunology, University of Illinois at Chicago and Chicago Veterans Administration Medical Center, Chicago, IL, USA., gahecht@uic.edu Y1 - 2004/08// PY - 2004 DA - Aug 2004 SP - 783 EP - 793 PB - Blackwell Science Ltd VL - 6 IS - 8 SN - 1462-5814, 1462-5814 KW - TJ protein KW - occludin KW - claudin 1 KW - Microbiology Abstracts B: Bacteriology KW - Interaction KW - Immunoprecipitation KW - Escherichia coli KW - Epithelium KW - Infection KW - Electron microscopy KW - J 02846:Gastrointestinal tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18018705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=Enteropathogenic+Escherichia+coli+infection+leads+to+appearance+of+aberrant+tight+junctions+strands+in+the+lateral+membrane+of+intestinal+epithelial+cells&rft.au=Muza-Moons%2C+M+M%3BSchneeberger%2C+EE%3BHecht%2C+G+A&rft.aulast=Muza-Moons&rft.aufirst=M&rft.date=2004-08-01&rft.volume=6&rft.issue=8&rft.spage=783&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2004.00404.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Epithelium; Interaction; Immunoprecipitation; Infection; Electron microscopy DO - http://dx.doi.org/10.1111/j.1462-5822.2004.00404.x ER - TY - JOUR T1 - Some novel insights into the pathogenesis of alcoholic steatosis AN - 17795843; 6141281 AB - The pathogenesis of alcoholic steatosis is a complex process that is manifested through several mechanisms involving some of or all the following body metabolism components: increased fat synthesis, increased mobilization of depot fat, defective export of fat from the liver, and decreased fat breakdown. Some of the novel findings in these mechanisms involve the down-regulation of peroxisome proliferator-activated receptor alpha and up-regulation of lipogenic enzymes through the induction of sterol regulatory element-binding protein. Yet another mechanism that remains viable is the adenosine 5'-monophosphate- activated protein kinase, which, through a complex mechanism, may regulate the relative concentrations of intracellular malonyl coenzyme A and long-chain acyl- coenzyme A, the key metabolites responsible for the balance between fat synthesis versus degradation pathways. Finally, excess dietary intake of omega-6 polyunsaturated fatty acids may exacerbate alcohol-induced onset of hepatic steatosis and alcoholic liver disease. This may explain why supplementation with lecithin containing omega-6 polyunsaturated fatty acids in a recent clinical trial in human beings failed to show any beneficial effects, although it was partially effective in an animal model. In contrast, dietary intake of omega-3 polyunsaturated fatty acids in moderation may have a protective effect against steatosis and alcoholic liver disease. JF - Alcohol AU - Lakshman, M R AD - Lipid Research Laboratory (151T), VA Medical Center, 50 Irving Street NW, Washington, DC 20422, USA, raj.lakshman@med.va.gov Y1 - 2004/08// PY - 2004 DA - Aug 2004 SP - 45 EP - 48 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 34 IS - 1 SN - 0741-8329, 0741-8329 KW - adenosine 5'-monophosphate KW - Toxicology Abstracts KW - Liver diseases KW - Peroxisome proliferator-activated receptors KW - steatosis KW - Animal models KW - Lecithin KW - Metabolites KW - Sterol regulatory element-binding protein KW - Clinical trials KW - Dietary intake KW - Alcoholics KW - Coenzyme A KW - Dietary supplements KW - Fatty acids KW - Fatty liver KW - Protein kinase KW - Fat metabolism KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17795843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol&rft.atitle=Some+novel+insights+into+the+pathogenesis+of+alcoholic+steatosis&rft.au=Lakshman%2C+M+R&rft.aulast=Lakshman&rft.aufirst=M&rft.date=2004-08-01&rft.volume=34&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Alcohol&rft.issn=07418329&rft_id=info:doi/10.1016%2Fj.alcohol.2004.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Alcoholics; steatosis; Fatty acids; Liver diseases; Coenzyme A; Dietary intake; Lecithin; Clinical trials; Sterol regulatory element-binding protein; Protein kinase; Metabolites; Fat metabolism; Fatty liver; Animal models; Peroxisome proliferator-activated receptors; Dietary supplements DO - http://dx.doi.org/10.1016/j.alcohol.2004.08.004 ER - TY - JOUR T1 - Fatal Lactic Acidosis Associated with Coadministration of Didanosine and Tenofovir Disoproxil Fumarate AN - 17791155; 6038136 AB - Lactic acidosis is an uncommon but potentially life-threatening adverse effect of didanosine. When given concomitantly with tenofovir disoproxil fumarate (DF), the area under the concentration-time curve of didanosine is increased by 48-60%. A 63-year-old man with human immunodeficiency virus (HIV) infection tolerated several didanosine-containing antiretroviral regimens. He developed generalized weakness, loss of appetite, weight loss, nausea, and vomiting 1.5 years after tenofovir DF was added to his didanosine-containing regimen. He was diagnosed with lactic acidosis and died after a 13-day hospital stay, when his lactate level increased to 189.7 mg/dl and his arterial blood gas pH value fell to 6.75. Health care providers should maintain a high index of suspicion for lactic acidosis in patients with HIV infection who receive didanosine and tenofovir DF concurrently. For patients receiving antiretroviral regimens containing this drug combination, it would be prudent to monitor lactate levels periodically. This is especially important when patients experience symptoms suggestive of lactic acidosis, such as weakness, abdominal pain, weight loss, nausea and vomiting, and shortness of breath. JF - Pharmacotherapy AU - Guo, Y AU - Fung, H B AD - BCPS, Critical Care Center, Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA, horatio.fung@med.va.gov Y1 - 2004/08// PY - 2004 DA - Aug 2004 SP - 1089 EP - 1094 VL - 24 IS - 8 SN - 0277-0008, 0277-0008 KW - HIV KW - Toxicology Abstracts KW - Vomiting KW - Pain KW - tenofovir KW - Appetite KW - Infection KW - Lactic acidosis KW - Blood KW - Didanosine KW - Human immunodeficiency virus KW - Lactic acid KW - Nausea KW - Drugs KW - Side effects KW - Hospitals KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17791155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Fatal+Lactic+Acidosis+Associated+with+Coadministration+of+Didanosine+and+Tenofovir+Disoproxil+Fumarate&rft.au=Guo%2C+Y%3BFung%2C+H+B&rft.aulast=Guo&rft.aufirst=Y&rft.date=2004-08-01&rft.volume=24&rft.issue=8&rft.spage=1089&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Vomiting; tenofovir; Pain; Infection; Appetite; Lactic acidosis; Blood; Didanosine; Lactic acid; Nausea; Drugs; Side effects; Hospitals; Human immunodeficiency virus ER - TY - JOUR T1 - Prescribing practices for the treatment of hepatitis C in a Veterans Affairs medical center. AN - 66824251; 15332696 JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Mangin, Emmanelle F M AU - Jones, William N AD - Southern Arizona Veterans Affairs Health Care System, Tucson, AZ 85723, USA. emmanuelle.Mangin@med.va.gov Y1 - 2004/07/15/ PY - 2004 DA - 2004 Jul 15 SP - 1479 EP - 1482 VL - 61 IS - 14 SN - 1079-2082, 1079-2082 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - Recombinant Proteins KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2b KW - 43K1W2T1M6 KW - Ribavirin KW - 49717AWG6K KW - peginterferon alfa-2b KW - G8RGG88B68 KW - Index Medicus KW - United States KW - Genotype KW - Drug Therapy, Combination KW - Humans KW - Treatment Outcome KW - Retrospective Studies KW - Middle Aged KW - Male KW - Female KW - Hospitals, Veterans KW - Antiviral Agents -- therapeutic use KW - Ribavirin -- therapeutic use KW - Interferon-alpha -- therapeutic use KW - Interferon-alpha -- adverse effects KW - Hepatitis C -- drug therapy KW - Ribavirin -- economics KW - Interferon-alpha -- economics KW - Antiviral Agents -- economics KW - Antiviral Agents -- adverse effects KW - Hepatitis C -- genetics KW - Ribavirin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66824251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Prescribing+practices+for+the+treatment+of+hepatitis+C+in+a+Veterans+Affairs+medical+center.&rft.au=Mangin%2C+Emmanelle+F+M%3BJones%2C+William+N&rft.aulast=Mangin&rft.aufirst=Emmanelle+F&rft.date=2004-07-15&rft.volume=61&rft.issue=14&rft.spage=1479&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-10-19 N1 - Date created - 2004-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacist interventions in pain management. AN - 66824049; 15332699 JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Lynn, Marsha A AD - College of Pharmacy, University of Florida, Gainesville, USA. marsha.lynn@med.va.gov Y1 - 2004/07/15/ PY - 2004 DA - 2004 Jul 15 SP - 1487 EP - 1489 VL - 61 IS - 14 SN - 1079-2082, 1079-2082 KW - Analgesics KW - 0 KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Adult KW - Pain Measurement KW - Aged KW - Middle Aged KW - Male KW - Female KW - Pain -- drug therapy KW - Analgesics -- administration & dosage KW - Pharmacy Service, Hospital KW - Analgesics -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66824049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Pharmacist+interventions+in+pain+management.&rft.au=Lynn%2C+Marsha+A&rft.aulast=Lynn&rft.aufirst=Marsha&rft.date=2004-07-15&rft.volume=61&rft.issue=14&rft.spage=1487&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-10-19 N1 - Date created - 2004-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of pallidal and subthalamic deep brain stimulation for the treatment of levodopa-induced dyskinesias. AN - 66737288; 15264772 AB - Deep brain stimulation (DBS) can relieve dyskinesias effectively and safely. This modality is applied most commonly in the treatment of dyskinesias associated with levodopa therapy for Parkinson disease. The subthalamic nucleus (STN) and globus pallidus internus (GPi) are the most common surgical targets. Deep brain stimulation of the GP has a direct antidyskinetic effect, whereas relief of dyskinesias by DBS of the STN depends on postoperative reduction of dopaminergic medications. Outcomes are similar for DBS in these two sites despite the different mechanisms by which the stimulation relieves dyskinesias. Deep brain stimulation of the STN has become the surgical treatment of choice in many movement disorders programs but this modality has not been compared with DBS of the GPi in randomized controlled trials, and the superiority of one site over the other remains unproven. In the absence of data demonstrating superiority, selection of the stimulation target should be individualized to meet the needs of each patient. Selection of the target should be based on the patient's most disabling symptoms, response to medications (including side effects), and the goals of therapy, with consideration given to the different antidyskinetic effects of DBS of the STN and GPi. JF - Neurosurgical focus AU - Follett, Kenneth A AD - Department of Neurosurgery, University of Iowa Hospitals and Clinics, and Iowa City Veterans Administration Medical Center, Iowa City, Iowa 52242, USA. Y1 - 2004/07/15/ PY - 2004 DA - 2004 Jul 15 SP - 1 VL - 17 IS - 1 KW - Antiparkinson Agents KW - 0 KW - Levodopa KW - 46627O600J KW - Index Medicus KW - Parkinson Disease -- therapy KW - Electrodes, Implanted KW - Combined Modality Therapy KW - Humans KW - Treatment Outcome KW - Thalamus -- physiopathology KW - Organ Specificity KW - Parkinson Disease -- drug therapy KW - Dyskinesias -- therapy KW - Dyskinesia, Drug-Induced -- therapy KW - Antiparkinson Agents -- adverse effects KW - Subthalamic Nucleus -- physiopathology KW - Levodopa -- therapeutic use KW - Antiparkinson Agents -- therapeutic use KW - Globus Pallidus -- physiopathology KW - Dyskinesia, Drug-Induced -- etiology KW - Levodopa -- adverse effects KW - Electric Stimulation Therapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66737288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurosurgical+focus&rft.atitle=Comparison+of+pallidal+and+subthalamic+deep+brain+stimulation+for+the+treatment+of+levodopa-induced+dyskinesias.&rft.au=Follett%2C+Kenneth+A&rft.aulast=Follett&rft.aufirst=Kenneth&rft.date=2004-07-15&rft.volume=17&rft.issue=1&rft.spage=E3&rft.isbn=&rft.btitle=&rft.title=Neurosurgical+focus&rft.issn=1092-0684&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-10-22 N1 - Date created - 2004-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Variations in evidence-based clinical practices in nine United States Veterans Administration opioid agonist therapy clinics. AN - 66658334; 15225893 AB - Opioid agonist therapy (OAT) for opioid dependence has a strong evidence base, but clinical practice often does not conform to evidence-based practices. The goal of the OpiATE Initiative is to improve patient outcomes by implementing four evidence-based practices in United States Veterans Administration OAT clinics: (1) long-term maintenance orientation, (2) adequate dosing, (3) adequate counseling, and (4) use of contingency management. The OpiATE monitoring system (OMS) was developed to help clinics assess concordance with evidence-based practices. For each patient, counselors record current agonist dose, recent counseling frequency, length of treatment, and urine toxicology results. For patients with sub-standard agonist doses, an algorithm was used to determine if the current dose was clinically appropriate. Maintenance orientation was assessed using the abstinence orientation scale. Concordance with counseling recommendations was uniformly high, concordance with maintenance orientation and dosing recommendations varied widely across clinics, and concordance with contingency management principles was low. Abstinence orientation scores were negatively correlated with dose and patient retention. Dose was negatively correlated with percent of urine screens positive for non-medical opioids and other illicit substances. The OMS was well accepted by clinic staff. Wide variability in clinical practices and outcomes across clinics supports the importance of individualizing quality improvement strategies to address specific performance gaps. JF - Drug and alcohol dependence AU - Willenbring, Mark L AU - Hagedorn, Hildi J AU - Postier, Andrea C AU - Kenny, Marie AD - Minneapolis VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA. mark.willenbring@med.va.gov Y1 - 2004/07/15/ PY - 2004 DA - 2004 Jul 15 SP - 97 EP - 106 VL - 75 IS - 1 SN - 0376-8716, 0376-8716 KW - Analgesics, Opioid KW - 0 KW - Index Medicus KW - United States KW - Humans KW - Substance Abuse Treatment Centers -- statistics & numerical data KW - Substance Abuse Treatment Centers -- methods KW - Evidence-Based Medicine -- statistics & numerical data KW - Evidence-Based Medicine -- methods KW - Analgesics, Opioid -- therapeutic use KW - United States Department of Veterans Affairs -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66658334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Variations+in+evidence-based+clinical+practices+in+nine+United+States+Veterans+Administration+opioid+agonist+therapy+clinics.&rft.au=Willenbring%2C+Mark+L%3BHagedorn%2C+Hildi+J%3BPostier%2C+Andrea+C%3BKenny%2C+Marie&rft.aulast=Willenbring&rft.aufirst=Mark&rft.date=2004-07-15&rft.volume=75&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-10-12 N1 - Date created - 2004-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Management of alcohol withdrawal delirium. An evidence-based practice guideline. AN - 66698842; 15249349 AB - Alcohol withdrawal delirium is the most serious manifestation of alcohol withdrawal. Evidence suggests that appropriate care improves mortality, but systematic reviews are unavailable. Articles with original data on management of alcohol withdrawal delirium underwent structured review and meta-analysis. Meta-analysis of 9 prospective controlled trials demonstrated that sedative-hypnotic agents are more effective than neuroleptic agents in reducing duration of delirium and mortality, with a relative risk of death when using neuroleptic agents of 6.6. Statistically significant differences among various benzodiazepines and barbiturates were not found. No deaths were reported in 217 patients from trials using benzodiazepines or barbiturates. Control of agitation should be achieved using parenteral rapid-acting sedative-hypnotic agents that are cross-tolerant with alcohol. Adequate doses should be used to maintain light somnolence for the duration of delirium. Coupled with comprehensive supportive medical care, this approach is highly effective in preventing morbidity and mortality. JF - Archives of internal medicine AU - Mayo-Smith, Michael F AU - Beecher, Lee H AU - Fischer, Timothy L AU - Gorelick, David A AU - Guillaume, Jeanette L AU - Hill, Arnold AU - Jara, Gail AU - Kasser, Chris AU - Melbourne, John AU - Working Group on the Management of Alcohol Withdrawal Delirium, Practice Guidelines Committee, American Society of Addiction Medicine AD - Primary Care Service, Veterans Administration Medical Center, Manchester, NH 03104, USA. Michael.Mayo-Smith@med.va.gov ; Working Group on the Management of Alcohol Withdrawal Delirium, Practice Guidelines Committee, American Society of Addiction Medicine Y1 - 2004/07/12/ PY - 2004 DA - 2004 Jul 12 SP - 1405 EP - 1412 VL - 164 IS - 13 SN - 0003-9926, 0003-9926 KW - Antipsychotic Agents KW - 0 KW - Benzodiazepines KW - 12794-10-4 KW - Abridged Index Medicus KW - Index Medicus KW - Psychomotor Agitation -- drug therapy KW - Psychomotor Agitation -- economics KW - Costs and Cost Analysis KW - Antipsychotic Agents -- standards KW - Antipsychotic Agents -- therapeutic use KW - Disease Management KW - Humans KW - Benzodiazepines -- standards KW - Controlled Clinical Trials as Topic KW - Benzodiazepines -- therapeutic use KW - Prospective Studies KW - Antipsychotic Agents -- economics KW - Benzodiazepines -- economics KW - Meta-Analysis as Topic KW - Evidence-Based Medicine -- standards KW - Alcohol Withdrawal Delirium -- economics KW - Alcohol Withdrawal Delirium -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66698842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Management+of+alcohol+withdrawal+delirium.+An+evidence-based+practice+guideline.&rft.au=Mayo-Smith%2C+Michael+F%3BBeecher%2C+Lee+H%3BFischer%2C+Timothy+L%3BGorelick%2C+David+A%3BGuillaume%2C+Jeanette+L%3BHill%2C+Arnold%3BJara%2C+Gail%3BKasser%2C+Chris%3BMelbourne%2C+John%3BWorking+Group+on+the+Management+of+Alcohol+Withdrawal+Delirium%2C+Practice+Guidelines+Committee%2C+American+Society+of+Addiction+Medicine&rft.aulast=Mayo-Smith&rft.aufirst=Michael&rft.date=2004-07-12&rft.volume=164&rft.issue=13&rft.spage=1405&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-09-21 N1 - Date created - 2004-07-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 2005 Feb 14;165(3):346 [15710803] ACP J Club. 2005 Jan-Feb;142(1):4 [15656545] Arch Intern Med. 2005 Mar 14;165(5):586; author reply 587 [15767537] Arch Intern Med. 2005 Mar 14;165(5):586; author reply 587 [15767538] Arch Intern Med. 2005 Mar 14;165(5):587; author reply 587 [15767540] Erratum In: Arch Intern Med. 2004 Oct 11;164(18):2068 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A refractory case of erythromelalgia involving the ears. AN - 85381387; pmid-15239031 AB - Erythromelalgia is a rare syndrome that is characterized by episodic attacks of burning pain, erythema, and increased temperature usually affecting the extremities, which is aggravated by warmth or exercise. We describe a patient with a 3-year history of refractory burning pain and red ears. A review of clinical features, disease classification, associated diseases, and treatment of this disease is presented. JF - American journal of otolaryngology AU - Ramirez, Claudia C AU - Kirsner, Robert S AD - Veterans Administration Medical Center, Miami, FL 33125, USA. Y1 - 2004/07// PY - 2004 DA - Jul 2004 SP - 251 EP - 254 VL - 25 IS - 4 SN - 0196-0709, 0196-0709 KW - Index Medicus KW - National Library of Medicine KW - Biopsy KW - Cryoglobulins: analysis KW - Diagnosis, Differential KW - *Ear Diseases: diagnosis KW - Ear Diseases: drug therapy KW - *Ear, External: pathology KW - *Erythromelalgia: diagnosis KW - Erythromelalgia: drug therapy KW - Humans KW - Male KW - Middle Aged KW - Pain UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85381387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+otolaryngology&rft.atitle=A+refractory+case+of+erythromelalgia+involving+the+ears.&rft.au=Ramirez%2C+Claudia+C%3BKirsner%2C+Robert+S&rft.aulast=Ramirez&rft.aufirst=Claudia&rft.date=2004-07-01&rft.volume=25&rft.issue=4&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=American+journal+of+otolaryngology&rft.issn=01960709&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Treatment of radiation-induced fibrosis of the face with manual compression therapy. AN - 85372623; pmid-15372919 AB - Radiation-induced fibrosis (RIF) is an uncommon complication of radiation therapy. RIF most often occurs in the extremities; it is rare in the head and neck. Only a few medical treatments for RIF are available, and they have been mediocre at best. We describe a case of RIF of the face that was treated successfully with a nonmedical modality: manual compression therapy. JF - Ear, nose, & throat journal AU - Oppenheimer, Randy AU - Finkel, Rima AU - Brennan, Andrea AD - Department of Surgery, Carl T. Hayden VA Medical Center, Phoenix, AZ 85012, USA. randy.oppenheimer@med.va.gov Y1 - 2004/07// PY - 2004 DA - Jul 2004 SP - 478 EP - 480 VL - 83 IS - 7 SN - 0145-5613, 0145-5613 KW - Index Medicus KW - National Library of Medicine KW - *Bandages KW - *Edema: etiology KW - Edema: pathology KW - *Edema: therapy KW - Fibrosis KW - Humans KW - Male KW - Middle Aged KW - *Radiodermatitis: etiology KW - Radiodermatitis: pathology KW - *Radiodermatitis: therapy KW - *Radiotherapy: adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85372623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear%2C+nose%2C+%26+throat+journal&rft.atitle=Treatment+of+radiation-induced+fibrosis+of+the+face+with+manual+compression+therapy.&rft.au=Oppenheimer%2C+Randy%3BFinkel%2C+Rima%3BBrennan%2C+Andrea&rft.aulast=Oppenheimer&rft.aufirst=Randy&rft.date=2004-07-01&rft.volume=83&rft.issue=7&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=Ear%2C+nose%2C+%26+throat+journal&rft.issn=01455613&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Assessing continuity of care practices in substance use disorder treatment programs. AN - 66891181; 15376826 AB - The purpose of this article is to describe the development and psychometric properties of parallel program-level and individual-level versions of the Continuity of Care Practices Survey (CCPS-P and CCPS-I), a measure that assesses four dimensions of continuity of care practices in substance use disorder (SUD) treatment programs. CCPS subscales assess staff efforts to ensure provider continuity, maintain contact with patients, coordinate care among providers and connect patients to community resources. Program-level CCPS data were obtained from directors/coordinators of 129 intensive inpatient/residential and outpatient Department of Veterans Affairs SUD programs. These data were used to examine the internal consistency and discriminant validity of the CCPS-P. A parallel individual-level CCPS-I completed by counselors for 835 patients in a subsample of 28 SUD programs, assessed the continuity of care services that staff provided to individual patients. These data were used to examine the predictive validity of the CCPS-P. CCPS-P and CCPS-I subscales demonstrated acceptable psychometric properties. Lack of significant correlations between CCPS-P subscales and SUD program characteristics (e.g., size, staffing) provided preliminary evidence for discriminant validity. CCPS-P subscales and the overall CCPS-P score predicted corresponding continuity of care services that staff provided to patients within programs, offering support for predictive validity. Managers can use the CCPS to monitor and improve SUD programs' continuity of care practices. The CCPS also enables researchers to determine the impact of continuity of care practices on the engagement of patients in continuing care and outcomes. JF - Journal of studies on alcohol AU - Schaefer, Jeanne A AU - Cronkite, Ruth AU - Ingudomnukul, Erin AD - Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System, 795 Willow Road (152), Menlo Park, California 94025, USA. Jeanne.Schaefer@med.va.gov Y1 - 2004/07// PY - 2004 DA - July 2004 SP - 513 EP - 520 VL - 65 IS - 4 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Regression Analysis KW - Analysis of Variance KW - Humans KW - Middle Aged KW - Psychometrics KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - Continuity of Patient Care -- statistics & numerical data KW - Substance Abuse Treatment Centers -- statistics & numerical data KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66891181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Assessing+continuity+of+care+practices+in+substance+use+disorder+treatment+programs.&rft.au=Schaefer%2C+Jeanne+A%3BCronkite%2C+Ruth%3BIngudomnukul%2C+Erin&rft.aulast=Schaefer&rft.aufirst=Jeanne&rft.date=2004-07-01&rft.volume=65&rft.issue=4&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-21 N1 - Date created - 2004-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Factors associated with readiness to stop smoking among patients in treatment for alcohol use disorder. AN - 66875376; 15370939 AB - The Timing of Alcohol and Smoking Cessation (TASC) Study is a randomized controlled trial that examines the optimal timing of intervention for nicotine dependence in patients with alcohol use disorders. A cross-sectional analysis of baseline characteristics of study participants was used to identify characteristics associated with readiness of patients in intensive treatment for alcohol abuse or dependence to quit smoking. Baseline characteristics of 499 subjects enrolled in the TASC trial were analyzed. Readiness to quit was assessed by two self-rated measures: being in the preparation/action stages of change and scoring at least an 8 on the Contemplation Ladder. Univariate analyses showed a higher prevalence of African-Americans and other minorities than Caucasian, among participants planning to quit in the next month (p = 0.005). There were no other differences between groups. Participants in the preparation/action stages of change experienced significantly lower rates of current (p = 0.011) and past (p = 0.014) major depressive disorder and displayed significantly less current depressive symptoms on the Beck Depression Inventory (p = 0.008). Patients with Contemplation Ladder ratings between 8 and 10 showed similar results. Logistic regression models consistently confirmed that the degree of depression was negatively associated with the intention to quit, but different models suggested that increasing age, shorter duration of smoking history, race other than white, and a greater number of past quit attempts were positively associated with readiness to quit. Among patients in intensive treatment for alcohol use disorders who smoke, a history of depressive disorder and depressive symptoms predict less interest in quitting smoking. JF - The American journal on addictions AU - Joseph, Anne AU - Lexau, Ben AU - Willenbring, Mark AU - Nugent, Sean AU - Nelson, Dave AD - Section of General Internal Medicine, Minneapolis VA Medical Center and University of Minnesota, Minneapolis, MN 55417, USA. Anne.M.Joseph@med.va.gov PY - 2004 SP - 405 EP - 417 VL - 13 IS - 4 SN - 1055-0496, 1055-0496 KW - Index Medicus KW - Cross-Sectional Studies KW - Models, Psychological KW - Psychiatric Status Rating Scales KW - Logistic Models KW - Depressive Disorder -- psychology KW - Humans KW - African Americans -- psychology KW - European Continental Ancestry Group -- psychology KW - Depressive Disorder -- diagnosis KW - Personality Inventory KW - Comorbidity KW - Smoking Cessation -- psychology KW - Intention KW - Alcohol-Related Disorders -- therapy KW - Smoking -- prevention & control KW - Patient Acceptance of Health Care -- psychology KW - Smoking -- epidemiology KW - Alcohol-Related Disorders -- psychology KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66875376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Factors+associated+with+readiness+to+stop+smoking+among+patients+in+treatment+for+alcohol+use+disorder.&rft.au=Joseph%2C+Anne%3BLexau%2C+Ben%3BWillenbring%2C+Mark%3BNugent%2C+Sean%3BNelson%2C+Dave&rft.aulast=Joseph&rft.aufirst=Anne&rft.date=2004-07-01&rft.volume=13&rft.issue=4&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-10 N1 - Date created - 2004-09-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Atazanavir: a new protease inhibitor to treat HIV infection. AN - 66762804; 15287232 AB - The pharmacology, pharmacokinetics, and clinical trials of and drug interactions and formulary considerations associated with atazanavir, the newest protease inhibitor (PI) to treat human immunodeficiency virus (HIV) infection, are evaluated. Clinical and pharmacokinetic trials were identified through a MEDLINE search. In addition, all available literature citations and meeting abstracts were obtained from the drug's manufacturer. All articles identified from the data sources were evaluated, and all information deemed relevant was included in this review. Data on atazanavir for the treatment of HIV infection are limited to several phase II and III trials, one of which is still ongoing. Atazanavir has shown efficacy comparable with other PIs and the nonnucleoside reverse-transcriptase inhibitor efavirenz in reducing HIV RNA levels, increasing CD4+ lymphocyte counts, and increasing the percentage of patients achieving clinically undetectable HIV RNA levels when given as the sole PI in treatment-naive patients, in combination with saquinavir in treatment-experienced patients, and with ritonavir-boosting regimens in highly treatment-experienced patients. Treatment-naive patients receiving atazanavir commonly develop a protease enzyme mutation on codon 50, which decreases HIV's susceptibility to atazanavir but may increase the susceptibility of the virus to other PIs. When atazanavir is given to patients with preexisting PI-related mutations, the virus's susceptibility to atazanavir is greatly reduced. The occurrence of lipid abnormalities, which has been a major concern with previous PIs, has not been shown to be troublesome in patients receiving atazanavir. Atazanavir may be used alone as a first-line PI, with saquinavir in treatment-experienced patients, or in combination with a ritonavir-boosting regimen in highly treatment-experienced patients as part of a salvage regimen. JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Musial, Bogdan L AU - Chojnacki, Joanna K AU - Coleman, Craig I AD - Primary Care Clinical Pharmacy Specialist, Connecticut Veterans Administration Healthcare System, West Haven, USA. Y1 - 2004/07/01/ PY - 2004 DA - 2004 Jul 01 SP - 1365 EP - 1374 VL - 61 IS - 13 SN - 1079-2082, 1079-2082 KW - HIV Protease Inhibitors KW - 0 KW - Oligopeptides KW - Pyridines KW - Atazanavir Sulfate KW - 4MT4VIE29P KW - Saquinavir KW - L3JE09KZ2F KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Interactions KW - Humans KW - Saquinavir -- administration & dosage KW - Clinical Trials as Topic KW - Saquinavir -- therapeutic use KW - Drug Resistance, Viral -- drug effects KW - Oligopeptides -- pharmacokinetics KW - Pyridines -- administration & dosage KW - Pyridines -- pharmacokinetics KW - Oligopeptides -- therapeutic use KW - Oligopeptides -- administration & dosage KW - HIV Infections -- drug therapy KW - HIV Protease Inhibitors -- pharmacokinetics KW - Pyridines -- therapeutic use KW - HIV Protease Inhibitors -- therapeutic use KW - HIV-1 KW - HIV Protease Inhibitors -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66762804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Atazanavir%3A+a+new+protease+inhibitor+to+treat+HIV+infection.&rft.au=Musial%2C+Bogdan+L%3BChojnacki%2C+Joanna+K%3BColeman%2C+Craig+I&rft.aulast=Musial&rft.aufirst=Bogdan&rft.date=2004-07-01&rft.volume=61&rft.issue=13&rft.spage=1365&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-10-19 N1 - Date created - 2004-08-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Am J Health Syst Pharm. 2004 Nov 1;61(21):2243 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vitro and in vivo comparison of human Escherichia coli heat-stable peptide analogues incorporating the 111In-DOTA group and distinct linker moieties. AN - 66724003; 15264876 AB - Three human Escherichia coli heat-stable peptide (STh) analogues, each containing a DOTA chelating group, were synthesized by SPPS and oxidative refolding and compared in in vitro and in vivo systems. One analogue, DOTA-F19-STh(1-19), contains an N-terminal DOTA group attached via an amide bond linkage to an STh moiety which is essentially wild-type except for a Tyr to Phe alteration at position 19 of the molecule. A second analogue, DOTA-R1,4,F19-STh(1-19), differs from the first in that asparagine residues in positions 1 and 4 have been altered to arginine residues in order to examine the effect of positively charged groups in the linker domain. A third analogue, DOTA-11AUN-F19-STh(1-19), differs from the first in that it incorporates an 11-aminoundecanoic acid spacer group between the DOTA group and the first asparagine residue. In vitro competitive binding assays utilizing T-84 human colon cancer cells demonstrated that significant alterations to the N-terminal region of the STh molecule were well tolerated and did not significantly affect binding affinity of STh for the guanylyl cyclase C (GC-C) receptor. Internalization and efflux studies of the indium-labeled species demonstrated that inclusion of positive charge in the linker moiety inhibits internalization of the compound within tumor cells. The characteristics of the three analogues were compared in an in vivo model utilizing T-84 human colon cancer cell xenografts in SCID mice. Clearance of all analogues was rapid, primarily via renal excretion into the urine, with >89% ID excreted into the urine at 1 h pi for all analogues. The 111In-DOTA-R1,4,F19-STh(1-19) and 111In-DOTA-11AUN-F19-STh(1-19) analogues both had longer residence times in the blood than did the 111In-DOTA-F19-STh(1-19) analogue, probably accounting for increased %ID/g values for tumors and nontarget tissues at 1 h pi. At 4 h pi, significant differences between analogues were only seen with respect to metabolic routes of excretion, indicating that increased blood residence time did not result in increased tumor residualization. Reduction of hepatic uptake of these compounds, however, could have significance in the development of agents for the imaging of hepatic metastases. The ability to manipulate in vivo pharmacodynamics and tumor uptake of radiolabeled STh peptides through modification of linker moieties is under continuing investigation in order to produce optimal imaging and therapeutic radiopharmaceuticals. JF - Bioconjugate chemistry AU - Giblin, Michael F AU - Gali, Hariprasad AU - Sieckman, Gary L AU - Owen, Nellie K AU - Hoffman, Timothy J AU - Forte, Leonard R AU - Volkert, Wynn A AD - Research Service, Harry S. Truman Memorial Veterans' Administration Hospital, Columbia, Missouri 65201, USA. PY - 2004 SP - 872 EP - 880 VL - 15 IS - 4 SN - 1043-1802, 1043-1802 KW - Chelating Agents KW - 0 KW - Escherichia coli Proteins KW - Indium Radioisotopes KW - Index Medicus KW - Molecular Structure KW - Animals KW - Humans KW - Protein Denaturation KW - Cell Line, Tumor KW - Mice KW - Tissue Distribution KW - Protein Binding KW - Chromatography, High Pressure Liquid KW - Molecular Weight KW - Neoplasm Transplantation KW - Inhibitory Concentration 50 KW - Female KW - Protein Renaturation KW - Escherichia coli Proteins -- pharmacokinetics KW - Escherichia coli Proteins -- chemistry KW - Hot Temperature KW - Chelating Agents -- pharmacokinetics KW - Escherichia coli Proteins -- metabolism KW - Chelating Agents -- chemistry KW - Escherichia coli Proteins -- administration & dosage KW - Chelating Agents -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66724003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+chemistry&rft.atitle=In+vitro+and+in+vivo+comparison+of+human+Escherichia+coli+heat-stable+peptide+analogues+incorporating+the+111In-DOTA+group+and+distinct+linker+moieties.&rft.au=Giblin%2C+Michael+F%3BGali%2C+Hariprasad%3BSieckman%2C+Gary+L%3BOwen%2C+Nellie+K%3BHoffman%2C+Timothy+J%3BForte%2C+Leonard+R%3BVolkert%2C+Wynn+A&rft.aulast=Giblin&rft.aufirst=Michael&rft.date=2004-07-01&rft.volume=15&rft.issue=4&rft.spage=872&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+chemistry&rft.issn=10431802&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-01-31 N1 - Date created - 2004-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The use of novel antipsychotics in the older patient with neurodegenerative disorders in the long-term care setting. AN - 66667690; 15228634 AB - Treating older patients with neurodegenerative disorders involves numerous challenges. The older patient population is expected to increase appreciably in the coming years; thus, there will be increasing numbers of these individuals requiring treatment. As a result, the appropriate choice of psychopharmacologic agents becomes an important decision in treating older patients with atypical antipsychotics. The atypical antipsychotic medications are replacing the high-potency conventional antipsychotics in the long-term care setting because of the lower risks of side effects. For instance, atypical antipsychotics have lower rates of extrapyramidal side effects and tardive dyskinesia. Double-blind placebo-controlled trials examining the use of risperidone and olanzapine have been published and indicate that both agents safely and effectively reduce agitation symptoms in long-term care patients with neurodegenerative disorders. For instance, based on these studies, the doses that appear efficacious in treating behavioral agitation in dementia are 0.5 to 1.5 mg per day of risperidone and 5 to 10 mg per day of olanzapine. In addition, there are open-label studies examining the use of quetiapine, which suggest that this agent is also safe and efficacious in patients with dementia. Doses used range approximately from 25 to 350 mg per day. Very few studies are available examining the newest atypical antipsychotics, ziprasidone and aripiprazole, in patients with neurodegenerative disorders. These studies do suggest that ziprasidone and aripiprazole are worth further study in the long-term care setting. JF - Journal of the American Medical Directors Association AU - Kasckow, J W AU - Mulchahey, J J AU - Mohamed, S AD - Cincinnati Veterans Administration Medical Center, Psychiatry Service, and Department of Psychiatry, University of Cincinnati School of Medicine, OH 45220, USA. jkasckow@pol.net PY - 2004 SP - 242 EP - 248 VL - 5 IS - 4 SN - 1525-8610, 1525-8610 KW - Antipsychotic Agents KW - 0 KW - Dibenzothiazepines KW - Piperazines KW - Quinolones KW - Thiazoles KW - Benzodiazepines KW - 12794-10-4 KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - ziprasidone KW - 6UKA5VEJ6X KW - Aripiprazole KW - 82VFR53I78 KW - Risperidone KW - L6UH7ZF8HC KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - United States KW - Randomized Controlled Trials as Topic KW - Quinolones -- therapeutic use KW - Dibenzothiazepines -- pharmacology KW - Humans KW - Piperazines -- therapeutic use KW - Aged KW - Quality of Life KW - Piperazines -- pharmacology KW - Risperidone -- pharmacology KW - Thiazoles -- pharmacology KW - Benzodiazepines -- therapeutic use KW - Risk Factors KW - Long-Term Care KW - Benzodiazepines -- pharmacology KW - Risperidone -- therapeutic use KW - Thiazoles -- therapeutic use KW - Dibenzothiazepines -- therapeutic use KW - Quinolones -- pharmacology KW - Neurodegenerative Diseases -- drug therapy KW - Antipsychotic Agents -- therapeutic use KW - Antipsychotic Agents -- pharmacology KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66667690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Directors+Association&rft.atitle=The+use+of+novel+antipsychotics+in+the+older+patient+with+neurodegenerative+disorders+in+the+long-term+care+setting.&rft.au=Kasckow%2C+J+W%3BMulchahey%2C+J+J%3BMohamed%2C+S&rft.aulast=Kasckow&rft.aufirst=J&rft.date=2004-07-01&rft.volume=5&rft.issue=4&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Directors+Association&rft.issn=15258610&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-27 N1 - Date created - 2004-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A double-blind placebo-controlled pilot study of risperidone for decreasing cue-elicited craving in recently withdrawn cocaine dependent patients. AN - 66656875; 15223093 AB - Cocaine use causes an initial increase in dopamine and serotonin neurotransmission that is largely responsible for the pleasurable and reinforcing effects of the drug. Dysregulation of these neurotransmitters during withdrawal plays an important role in craving. Recent research has focused on the use of dopamine and serotonin antagonists early in recovery to reduce cocaine craving in both schizophrenic and non-schizophrenic cocaine dependent patients. This 2-week, double blind, placebo-controlled study compared risperidone vs. placebo in reducing cue-elicited cocaine craving. Thirty-four subjects with cocaine dependence were randomized to either risperidone or a placebo and underwent a weekly cue-exposure procedure. Although both groups had a reduction in craving over time, there were no significant differences among those treated with risperidone (n=19) compared to those taking a placebo (n=16) on the four craving dimensions. The results do not support the hypothesis that risperidone reduces cocaine craving among non-schizophrenic cocaine-dependent individuals. JF - Journal of substance abuse treatment AU - Smelson, David A AU - Williams, John AU - Ziedonis, Douglas AU - Sussner, Bradley D AU - Losonczy, Miklos F AU - Engelhart, Charles AU - Kaune, Maureen AD - Department of Veterans Affairs, VISN 3 Mental Illness Research, Education and Clinical Center, Bronx, NY, USA. David.Smelson@med.va.gov Y1 - 2004/07// PY - 2004 DA - July 2004 SP - 45 EP - 49 VL - 27 IS - 1 SN - 0740-5472, 0740-5472 KW - Dopamine Antagonists KW - 0 KW - Serotonin Antagonists KW - Risperidone KW - L6UH7ZF8HC KW - Index Medicus KW - Behavior, Addictive KW - Analysis of Variance KW - Double-Blind Method KW - Humans KW - Adult KW - Cues KW - Pilot Projects KW - New Jersey KW - Serotonin Antagonists -- therapeutic use KW - Dopamine Antagonists -- therapeutic use KW - Risperidone -- therapeutic use KW - Cocaine-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66656875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=A+double-blind+placebo-controlled+pilot+study+of+risperidone+for+decreasing+cue-elicited+craving+in+recently+withdrawn+cocaine+dependent+patients.&rft.au=Smelson%2C+David+A%3BWilliams%2C+John%3BZiedonis%2C+Douglas%3BSussner%2C+Bradley+D%3BLosonczy%2C+Miklos+F%3BEngelhart%2C+Charles%3BKaune%2C+Maureen&rft.aulast=Smelson&rft.aufirst=David&rft.date=2004-07-01&rft.volume=27&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-11-19 N1 - Date created - 2004-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fibroblast growth factor-10 attenuates H2O2-induced alveolar epithelial cell DNA damage: role of MAPK activation and DNA repair. AN - 66650904; 14975937 AB - Fibroblast growth factor-10 (FGF-10), an alveolar epithelial cell (AEC) mitogen that is critical for lung development, may promote AEC repair. We determined whether FGF-10 attenuates H2O2-induced, A549 and rat alveolar type II cell DNA damage. We show that FGF-10 prevents H2O2-induced DNA damage assessed by an alkaline elution, ethidium bromide fluorescence as well as by a comet assay. Mitogen-activated protein kinase inhibitors abolished the protective effect of FGF-10 against H2O2-induced DNA damage yet had no effect on H2O2-induced DNA damage. A Grb2-SOS inhibitor (SH3 binding peptide), an Ras inhibitor (farnesyl transferase inhibitor 277), and an Raf-1 inhibitor (forskolin) each prevented FGF-10- and H2O2-induced A549 cell ERK1/2 phosphorylation. Also, FGF-10 and H2O2 each induced negligible ERK1/2 phosphorylation in Ras dominant-negative (N17) cells. Inhibitors of Ras and Raf-1 blocked the protective effect of FGF-10 against H2O2-induced DNA damage but had no effect on H2O2-induced DNA damage. Furthermore, cold conditions and aphidicolin, an inhibitor of DNA polymerase-alpha, -delta, and -epsilon, each blocked the protective effects of FGF-10, suggesting a role for DNA repair. We conclude that FGF-10 attenuates H2O2-induced AEC DNA damage by mechanisms that involve activation of Grb2-SOS/Ras/RAF-1/ERK1/2 pathway and DNA repair. JF - American journal of respiratory cell and molecular biology AU - Upadhyay, Daya AU - Bundesmann, Michael AU - Panduri, Vijayalakshmi AU - Correa-Meyer, Eduardo AU - Kamp, David W AD - Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Veterans Administration Chicago Health Care System, Chicago, IL 60611, USA. Y1 - 2004/07// PY - 2004 DA - July 2004 SP - 107 EP - 113 VL - 31 IS - 1 SN - 1044-1549, 1044-1549 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Enzyme Inhibitors KW - FGF10 protein, human KW - Fgf10 protein, rat KW - Fibroblast Growth Factor 10 KW - GRB2 Adaptor Protein KW - GRB2 protein, human KW - Grb2 protein, rat KW - Nucleic Acid Synthesis Inhibitors KW - Oxidants KW - Proteins KW - Fibroblast Growth Factors KW - 62031-54-3 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Proto-Oncogene Proteins c-raf KW - EC 2.7.11.1 KW - Mitogen-Activated Protein Kinase 3 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinases KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - ras Proteins KW - EC 3.6.5.2 KW - Index Medicus KW - Animals KW - MAP Kinase Signaling System -- physiology KW - Humans KW - Proto-Oncogene Proteins c-raf -- antagonists & inhibitors KW - Rats KW - Mitogen-Activated Protein Kinases -- drug effects KW - Oxidants -- antagonists & inhibitors KW - MAP Kinase Signaling System -- drug effects KW - Mitogen-Activated Protein Kinases -- metabolism KW - Hydrogen Peroxide -- antagonists & inhibitors KW - Proto-Oncogene Proteins c-raf -- metabolism KW - Proteins -- metabolism KW - DNA Repair -- drug effects KW - Hydrogen Peroxide -- toxicity KW - DNA Repair -- genetics KW - ras Proteins -- antagonists & inhibitors KW - Proteins -- antagonists & inhibitors KW - Oxidants -- toxicity KW - Enzyme Inhibitors -- pharmacology KW - ras Proteins -- metabolism KW - Cell Line KW - DNA-Directed DNA Polymerase -- metabolism KW - Respiratory Mucosa -- drug effects KW - Oxidative Stress -- genetics KW - Fibroblast Growth Factors -- metabolism KW - Fibroblast Growth Factors -- pharmacology KW - DNA Damage -- genetics KW - Pulmonary Fibrosis -- metabolism KW - DNA Damage -- drug effects KW - Pulmonary Fibrosis -- genetics KW - Respiratory Mucosa -- metabolism KW - Pulmonary Alveoli -- metabolism KW - Pulmonary Fibrosis -- chemically induced KW - Oxidative Stress -- drug effects KW - Pulmonary Alveoli -- drug effects KW - Pulmonary Alveoli -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66650904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Fibroblast+growth+factor-10+attenuates+H2O2-induced+alveolar+epithelial+cell+DNA+damage%3A+role+of+MAPK+activation+and+DNA+repair.&rft.au=Upadhyay%2C+Daya%3BBundesmann%2C+Michael%3BPanduri%2C+Vijayalakshmi%3BCorrea-Meyer%2C+Eduardo%3BKamp%2C+David+W&rft.aulast=Upadhyay&rft.aufirst=Daya&rft.date=2004-07-01&rft.volume=31&rft.issue=1&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-24 N1 - Date created - 2004-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - High levels of catalase and glutathione peroxidase activity dampen H2O2 signaling in human alveolar macrophages. AN - 66650520; 14962975 AB - Results are presented which support the hypothesis that adequate steady-state levels of hydrogen peroxide (H2O2) are required to overcome the effects of high catalase and glutathione peroxidase (GPx) expression for p38 mitogen-activated protein (MAP) kinase activation and tumor necrosis factor (TNF)-alpha gene expression in human alveolar macrophages stimulated with asbestos. We found significant differences in the types and amounts of reactive oxygen species generated in human blood monocytes compared with human alveolar macrophages. This difference in reactive oxygen species production is related, in part, to the differences in antioxidant enzyme expression and activity. Most importantly, catalase and GPx activities were significantly increased in alveolar macrophages compared with blood monocytes. Asbestos activated the p38 MAP kinase and induced TNF-alpha gene expression only in blood monocytes. Increasing the steady-state levels of H2O2 by using polyethylene glycol superoxide dismutase, an antioxidant that crosses the cell membrane, or aminotriazole, an irreversible inhibitor of catalase, allowed the p38 MAP kinase to be activated in alveolar macrophages. In addition, asbestos-stimulated macrophages cultured with polyethylene glycol superoxide dismutase had a significant increase in gene expression mediated by the TNF-alpha promoter. These results demonstrate that high catalase and GPx activity in human alveolar macrophages limits the effectiveness of H2O2 to act as a mediator of inflammatory gene expression. JF - American journal of respiratory cell and molecular biology AU - Carter, A Brent AU - Tephly, Linda A AU - Venkataraman, Sujatha AU - Oberley, Larry W AU - Zhang, Yuping AU - Buettner, Garry R AU - Spitz, Douglas R AU - Hunninghake, Gary W AD - Department of Medicine, University of Iowa Roy J. and Lucille A Carver College of Medicine, Iowa City Veterans Administration medical Center, Iowa City, IA 52242, USA. brent-carter@uiowa.edu Y1 - 2004/07// PY - 2004 DA - July 2004 SP - 43 EP - 53 VL - 31 IS - 1 SN - 1044-1549, 1044-1549 KW - RNA, Messenger KW - 0 KW - Reactive Oxygen Species KW - Tumor Necrosis Factor-alpha KW - Asbestos KW - 1332-21-4 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Catalase KW - EC 1.11.1.6 KW - Glutathione Peroxidase KW - EC 1.11.1.9 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - p38 Mitogen-Activated Protein Kinases KW - Amitrole KW - ZF80H5GXUF KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Humans KW - RNA, Messenger -- drug effects KW - Superoxide Dismutase -- metabolism KW - Tumor Necrosis Factor-alpha -- genetics KW - Superoxide Dismutase -- pharmacology KW - Promoter Regions, Genetic -- drug effects KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Up-Regulation -- drug effects KW - Adult KW - Lung -- enzymology KW - Promoter Regions, Genetic -- genetics KW - Mitogen-Activated Protein Kinases -- genetics KW - Amitrole -- pharmacology KW - Adolescent KW - Monocytes -- enzymology KW - Lung -- metabolism KW - Up-Regulation -- physiology KW - Signal Transduction -- physiology KW - Oxidative Stress -- physiology KW - Gene Expression Regulation, Enzymologic -- genetics KW - RNA, Messenger -- metabolism KW - Cells, Cultured KW - Signal Transduction -- drug effects KW - Oxidative Stress -- drug effects KW - Monocytes -- drug effects KW - Macrophages, Alveolar -- metabolism KW - Catalase -- metabolism KW - Glutathione Peroxidase -- metabolism KW - Pneumonia -- enzymology KW - Hydrogen Peroxide -- metabolism KW - Macrophages, Alveolar -- enzymology KW - Macrophages, Alveolar -- drug effects KW - Pneumonia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66650520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=High+levels+of+catalase+and+glutathione+peroxidase+activity+dampen+H2O2+signaling+in+human+alveolar+macrophages.&rft.au=Carter%2C+A+Brent%3BTephly%2C+Linda+A%3BVenkataraman%2C+Sujatha%3BOberley%2C+Larry+W%3BZhang%2C+Yuping%3BBuettner%2C+Garry+R%3BSpitz%2C+Douglas+R%3BHunninghake%2C+Gary+W&rft.aulast=Carter&rft.aufirst=A&rft.date=2004-07-01&rft.volume=31&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-24 N1 - Date created - 2004-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Efficacy and safety of rosuvastatin and atorvastatin in patients with hypercholesterolemia and a high risk of coronary heart disease: a randomized, controlled trial. AN - 66643902; 15215813 AB - This double-blind, multicenter, randomized trial compared rosuvastatin and atorvastatin for reducing low-density lipoprotein cholesterol (LDL-C) in adults with hypercholesterolemia and a high risk of coronary heart disease. After a 6-week dietary lead-in period, patients with LDL-C levels > or =160 and <250 mg/dL and triglyceride levels < or =400 mg/dL were randomly assigned to 24 weeks' treatment in 1 of 3 groups, each with forced dose titrations at 12 and 18 weeks. Starting and titrated doses for each group were rosuvastatin 5, 20, and 80 mg (n = 127); rosuvastatin 10, 40, and 80 mg (n = 128); and atorvastatin 10, 40, and 80 mg (n = 128). At 24 weeks, LDL-C was reduced significantly more with 80 mg rosuvastatin (combined rosuvastatin group) than with atorvastatin 80 mg (60% vs 52% [P <.001]). At 12 weeks, rosuvastatin 5 and 10 mg reduced LDL-C significantly more than atorvastatin 10 mg (40% [P <.01], 47% [P <.001] vs 35%). At 18 weeks, LDL-C reductions were also significantly greater in both rosuvastatin groups than in the atorvastatin group (52% [P <.01], 59% [P <.001] vs 47%). Consequently, more patients receiving rosuvastatin achieved LDL-C goals. Total cholesterol, high-density lipoprotein cholesterol (HDL-C), non-HDL-C, apolipoproteins B and A-I, and all lipid ratios were more favorably modified by rosuvastatin at 24 weeks (P <.01). Effects of the 2 agents on triglycerides were similar. Rosuvastatin was more efficacious than atorvastatin in modifying lipids in patients with hypercholesterolemia and a high coronary heart disease risk. JF - American heart journal AU - Schwartz, Gregory G AU - Bolognese, Michael A AU - Tremblay, Benoit P AU - Caplan, Richard AU - Hutchinson, Howard AU - Raza, Ali AU - Cressman, Michael AD - University of Colorado, Denver VA Medical Center, Denver, Colo 80220, USA. Gregory.Schwartz@med.va.gov Y1 - 2004/07// PY - 2004 DA - July 2004 SP - 1 VL - 148 IS - 1 KW - Anticholesteremic Agents KW - 0 KW - Apolipoproteins KW - Fluorobenzenes KW - Heptanoic Acids KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Pyrimidines KW - Pyrroles KW - Sulfonamides KW - Triglycerides KW - Atorvastatin Calcium KW - 48A5M73Z4Q KW - Rosuvastatin Calcium KW - 83MVU38M7Q KW - Cholesterol KW - 97C5T2UQ7J KW - Abridged Index Medicus KW - Index Medicus KW - Triglycerides -- blood KW - Double-Blind Method KW - Humans KW - Aged KW - Cholesterol -- blood KW - Apolipoproteins -- blood KW - Muscular Diseases -- chemically induced KW - Logistic Models KW - Aged, 80 and over KW - Adult KW - Least-Squares Analysis KW - Middle Aged KW - Anticholesteremic Agents -- therapeutic use KW - Anticholesteremic Agents -- adverse effects KW - Male KW - Female KW - Pyrroles -- adverse effects KW - Pyrimidines -- adverse effects KW - Hypercholesterolemia -- blood KW - Pyrimidines -- therapeutic use KW - Fluorobenzenes -- therapeutic use KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- therapeutic use KW - Pyrroles -- therapeutic use KW - Sulfonamides -- therapeutic use KW - Heptanoic Acids -- adverse effects KW - Hypercholesterolemia -- drug therapy KW - Sulfonamides -- adverse effects KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- adverse effects KW - Fluorobenzenes -- adverse effects KW - Heptanoic Acids -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66643902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+heart+journal&rft.atitle=Efficacy+and+safety+of+rosuvastatin+and+atorvastatin+in+patients+with+hypercholesterolemia+and+a+high+risk+of+coronary+heart+disease%3A+a+randomized%2C+controlled+trial.&rft.au=Schwartz%2C+Gregory+G%3BBolognese%2C+Michael+A%3BTremblay%2C+Benoit+P%3BCaplan%2C+Richard%3BHutchinson%2C+Howard%3BRaza%2C+Ali%3BCressman%2C+Michael&rft.aulast=Schwartz&rft.aufirst=Gregory&rft.date=2004-07-01&rft.volume=148&rft.issue=1&rft.spage=e4&rft.isbn=&rft.btitle=&rft.title=American+heart+journal&rft.issn=1097-6744&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-10-05 N1 - Date created - 2004-06-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CREATION OF A STABLE MAMMARY TUMOR CELL LINE THAT MAINTAINS FERTILITY-CYCLE TUMOR BIOLOGY OF THE PARENT TUMOR AN - 19336333; 8696346 JF - In Vitro Cellular & Developmental Biology - Animal AU - You, Shaojin AU - Li, Wei AU - Kobayashi, Minoru AU - Xiong, Yin AU - Hrushesky, William AU - Wood, Patricia AD - Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center (151), 6439 Garners Ferry Road, Columbia, South Carolina 29209, patricia.wood2@med.va.gov Y1 - 2004/07// PY - 2004 DA - Jul 2004 SP - 187 EP - 195 PB - Allen Press, Inc., 810 East Tenth St. VL - 40 IS - 7 SN - 1071-2690, 1071-2690 KW - Biotechnology and Bioengineering Abstracts KW - mammary neoplasma KW - fertility cycle KW - surgery KW - metastasis KW - Mammary gland KW - Tumors KW - Tumor cells KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19336333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.atitle=CREATION+OF+A+STABLE+MAMMARY+TUMOR+CELL+LINE+THAT+MAINTAINS+FERTILITY-CYCLE+TUMOR+BIOLOGY+OF+THE+PARENT+TUMOR&rft.au=You%2C+Shaojin%3BLi%2C+Wei%3BKobayashi%2C+Minoru%3BXiong%2C+Yin%3BHrushesky%2C+William%3BWood%2C+Patricia&rft.aulast=You&rft.aufirst=Shaojin&rft.date=2004-07-01&rft.volume=40&rft.issue=7&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.issn=10712690&rft_id=info:doi/10.1290%2F1543-706X%282004%29402.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mammary gland; Tumors; Tumor cells DO - http://dx.doi.org/10.1290/1543-706X(2004)40<187:COASMT>2.0.CO;2 ER - TY - JOUR T1 - Bacterial Clearance and Cytokine Profiles in a Murine Model of Postsurgical Nosocomial Pneumonia AN - 18015476; 5969515 AB - The development of a nosocomial pneumonia is facilitated by alterations in host innate pulmonary antibacterial defenses following surgical trauma, which can result in decreased pulmonary bacterial clearance and increased morbidity and mortality. In a murine model of postoperative nosocomial infection, surgical stress (laparotomy) decreased Escherichia coli clearance from the lungs of animals that underwent surgery. Consistent with previous studies, (i) pulmonary levels of tumor necrosis factor alpha at 6 h and of interleukin-1 beta (IL-1 beta ), IL-6, and gamma interferon (IFN- gamma ) at 24 h post-bacterial infection (PBI) were decreased in animals that underwent laparotomy 24 h prior to E. coli infection (LAP/E. coli) compared to animals that received E. coli only; (ii) KC and macrophage inhibitory protein 2 were elevated at 6 h PBI in LAP/E. coli animals compared to E. coli-only animals; however, at 24 h PBI, levels were higher in the E. coli-only group; (iii) at 24 h PBI, monocyte chemoattractant protein 1 was lower in the LAP/E. coli group compared to the E. coli-only group; (iv) IL- 10 levels were unaffected at all time points evaluated; and (v) the total number of neutrophils present in the lungs of LAP/E. coli animals at 6 h PBI was decreased in comparison to that in E. coli-only animals, resulting in decreased bacterial clearance and increased mortality in LAP/E. coli animals by 24 h PBI. Similar changes in cytokine profiles, pulmonary bacterial clearance, and mortality were consistent with reported findings in patients following surgical trauma. This model, therefore, provides a clinically relevant system in which the molecular and cellular mechanisms that lead to the development of nosocomial pneumonia can be further explored. JF - Clinical and Diagnostic Laboratory Immunology AU - Manderscheid, Patricia A AU - Bodkin, Ryan P AU - Davidson, Bruce A AU - Jensen, Erik AU - Russo, Thomas A AU - Knight, Paul R AD - Department of Anesthesiology. Department of Medicine. Department of Microbiology. The Witebsky Center for Microbial Pathogenesis, University at Buffalo. Veterans Administration Western New York Healthcare System, Buffalo, New York Y1 - 2004/07// PY - 2004 DA - Jul 2004 SP - 742 EP - 751 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 11 IS - 4 SN - 1071-412X, 1071-412X KW - man KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 6 KW - Postoperative infection KW - g-Interferon KW - Interleukin 1 KW - Tumor necrosis factor-a KW - ^g-Interferon KW - Nosocomial infection KW - Tumor necrosis factor-^a KW - Escherichia coli KW - Cytokines KW - Pneumonia KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18015476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Diagnostic+Laboratory+Immunology&rft.atitle=Bacterial+Clearance+and+Cytokine+Profiles+in+a+Murine+Model+of+Postsurgical+Nosocomial+Pneumonia&rft.au=Manderscheid%2C+Patricia+A%3BBodkin%2C+Ryan+P%3BDavidson%2C+Bruce+A%3BJensen%2C+Erik%3BRusso%2C+Thomas+A%3BKnight%2C+Paul+R&rft.aulast=Manderscheid&rft.aufirst=Patricia&rft.date=2004-07-01&rft.volume=11&rft.issue=4&rft.spage=742&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Diagnostic+Laboratory+Immunology&rft.issn=1071412X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Cytokines; Pneumonia; Nosocomial infection; Postoperative infection; Tumor necrosis factor-a; Interleukin 1; Interleukin 6; g-Interferon; Tumor necrosis factor-^a; ^g-Interferon ER - TY - JOUR T1 - Chondrocyte viability in press-fit cryopreserved osteochondral allografts AN - 17767889; 5928884 AB - The viability of chondrocytes in press-fit glycerol-preserved osteochondral allografts was compared to that in fresh autografts, after transplantation into load-bearing and non-load-bearing sites in mature sheep stifle joints. We used macroscopic grading, tonometer pen indentation testing, histology, sulfate uptake and viability as determined by confocal-microscopy to assess cartilage condition. Despite there being no statistical differences between macroscopic appearance and tonometer testing of all grafts, confocal microscopy and histology demonstrated a positive effect of load-bearing placement on cryopreserved osteochondral allografts. Allografts transplanted into load-bearing sites demonstrated superior confocal microscopy-measured chondrocyte viability (77% +/- 17%SD) than those transplanted into non-load-bearing sites (25% +/- 2%). Load-bearing effect was not seen in autografts (78% +/- 15%), and was comparable in adjacent cartilage (83% +/- 9%). Similarly, load-bearing allografts demonstrated histological scoring closer to that of autografts and adjacent cartilage, all of which fared significantly better than non-load-bearing allografts. Load-bearing allografts had a greater amount of fibrocartilage than autografts or adjacent cartilage but less fibrocartilage than non-load-bearing allografts. Both autografts and allografts had non-significant increases in metabolism compared to adjacent cartilage as measured by sulfate-uptake. Load-bearing placement improved chondrocyte viability of glycerol cryopreserved osteochondral allograft following a press-fit implantation. JF - Journal of Orthopaedic Research AU - Gole, MD AU - Poulsen, D AU - Marzo, J M AU - Ko, S-H AU - Ziv, I AD - Orthopaedics Section, Veterans Administration--Western New York Healthcare System, Suite 7B, 3495 Bailey Ave, Buffalo, NY 14215, USA, israelz@buffalo.edu Y1 - 2004/07// PY - 2004 DA - Jul 2004 SP - 781 EP - 787 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 22 IS - 4 SN - 0736-0266, 0736-0266 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Mechanical loading KW - Autografts KW - Transplantation KW - Cartilage KW - Chondrocytes KW - Cryopreservation KW - Allografts KW - T 20009:Bone grafts, implants, and biomaterials KW - W 30965:Miscellaneous, Reviews KW - W4 110:Biomedical Materials & Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17767889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Orthopaedic+Research&rft.atitle=Chondrocyte+viability+in+press-fit+cryopreserved+osteochondral+allografts&rft.au=Gole%2C+MD%3BPoulsen%2C+D%3BMarzo%2C+J+M%3BKo%2C+S-H%3BZiv%2C+I&rft.aulast=Gole&rft.aufirst=MD&rft.date=2004-07-01&rft.volume=22&rft.issue=4&rft.spage=781&rft.isbn=&rft.btitle=&rft.title=Journal+of+Orthopaedic+Research&rft.issn=07360266&rft_id=info:doi/10.1016%2Fj.orthres.2003.11.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cartilage; Autografts; Allografts; Transplantation; Chondrocytes; Mechanical loading; Cryopreservation DO - http://dx.doi.org/10.1016/j.orthres.2003.11.006 ER - TY - JOUR T1 - Regulation of central dopamine-2 receptor sensitivity by a proportional control thermostat in humans. AN - 66720373; 15261701 AB - Central dopamine-2 (D2) receptors are importantly involved in the pathogenesis and treatment of schizophrenia. Central D2 receptors are also involved in thermoregulation. Recently, a type of central nervous system proportional control thermostat was described that governs the magnitude of several serotonin receptor-mediated core body thermoregulatory responses in proportion to both the amount of nocturnal melatonin secreted and the minimum level of nocturnal core body temperature (Tmin). The present study investigated whether the magnitude of D2 receptor-mediated hypothermia--a putative index of central D2 receptor sensitivity--is also regulated by this proportional control thermostat in humans. Twenty healthy subjects had their 02:00 h melatonin concentrations (MT2am) and Tmin measured during consecutive sleep episodes and their core body temperature responses (TAUC) measured the next two mornings after oral ingestion of either the D2 receptor agonist bromocriptine 3.125 mg or placebo. We found that the bromocriptine-induced TAUC was significantly and independently correlated with both Tmin and MT2am. In conclusion, D2 receptor-mediated hypothermia, an index of central D2 receptor sensitivity, is regulated by a proportional control thermostat in humans. The abnormal D2 receptor function in schizophrenia could be related to dysfunction of this thermostat. Copyright 2004 Elsevier Ireland Ltd. JF - Psychiatry research AU - Schwartz, Paul J AU - Erk, Stanley D AD - Department of Psychiatry, Wright State University School of Medicine and University of Cincinnati College of Medicine, Dayton VA Medical Center, Building 302, Second Floor, 4100 West Third Street, Dayton, OH 45428, USA. Paul.Schwartz3@med.va.gov Y1 - 2004/06/30/ PY - 2004 DA - 2004 Jun 30 SP - 19 EP - 26 VL - 127 IS - 1-2 SN - 0165-1781, 0165-1781 KW - Dopamine Agonists KW - 0 KW - Receptors, Dopamine D2 KW - Bromocriptine KW - 3A64E3G5ZO KW - Melatonin KW - JL5DK93RCL KW - Index Medicus KW - Melatonin -- blood KW - Body Temperature -- drug effects KW - Humans KW - Circadian Rhythm -- drug effects KW - Adult KW - Hypothermia -- chemically induced KW - Adolescent KW - Male KW - Female KW - Body Temperature Regulation -- drug effects KW - Bromocriptine -- adverse effects KW - Dopamine Agonists -- therapeutic use KW - Schizophrenia -- metabolism KW - Corpus Striatum -- metabolism KW - Bromocriptine -- therapeutic use KW - Receptors, Dopamine D2 -- drug effects KW - Dopamine Agonists -- adverse effects KW - Schizophrenia -- drug therapy KW - Schizophrenia -- physiopathology KW - Receptors, Dopamine D2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66720373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Regulation+of+central+dopamine-2+receptor+sensitivity+by+a+proportional+control+thermostat+in+humans.&rft.au=Schwartz%2C+Paul+J%3BErk%2C+Stanley+D&rft.aulast=Schwartz&rft.aufirst=Paul&rft.date=2004-06-30&rft.volume=127&rft.issue=1-2&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-11-02 N1 - Date created - 2004-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vagus nerve stimulation inhibits harmaline-induced tremor. AN - 71918079; 15140653 AB - Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. This system receives rich sensory inputs, including visceral. We hypothesized that electrical vagus nerve stimulation (VNS) would suppress harmaline tremor, as measured with digitized motion power in the rat. Cervical vagus nerve stimulation suppressed power in the 8-12-Hz tremor range by 40%, whereas sham stimulation was ineffective. This study raises the possibility that activation of various sensory modalities, as well as visceral, may reduce tremor. JF - Brain research AU - Krahl, Scott E AU - Martin, Fredricka C AU - Handforth, Adrian AD - Research and Development Service, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA. scott.krahl@med.va.gov Y1 - 2004/06/11/ PY - 2004 DA - 2004 Jun 11 SP - 135 EP - 138 VL - 1011 IS - 1 SN - 0006-8993, 0006-8993 KW - Harmaline KW - CN58I4TOET KW - Index Medicus KW - Rats KW - Animals KW - Rats, Long-Evans KW - Male KW - Vagus Nerve -- physiology KW - Tremor -- drug therapy KW - Electric Stimulation Therapy KW - Tremor -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71918079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Vagus+nerve+stimulation+inhibits+harmaline-induced+tremor.&rft.au=Krahl%2C+Scott+E%3BMartin%2C+Fredricka+C%3BHandforth%2C+Adrian&rft.aulast=Krahl&rft.aufirst=Scott&rft.date=2004-06-11&rft.volume=1011&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-23 N1 - Date created - 2004-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical signs and symptoms in a large hereditary spastic paraparesis pedigree with a novel spastin mutation. AN - 85389865; pmid-15197701 AB - The most common form of autosomal dominant hereditary spastic paraparesis (HSP), SPG4, is caused by mutations in the spastin gene on chromosome 2p. This disease is characterized by intra- and interfamilial phenotypic variation. To determine the predictive values of clinical signs and symptoms in SPG4, we examined 43 members of a large pedigree with autosomal dominant HSP. We then identified the genetic etiology of the disorder in this family, a novel nonsense mutation in exon 1 of spastin, carried by 24 of the examined family members. The best clinical predictors of positive gene status were the presence of hyperreflexia in the lower extremities, >2 beats of ankle clonus, pes cavus, bladder symptoms and increased tone in the legs. The mean age of onset was 32.2 +/- 7.4 years, but the age of onset was earlier in children from 10 of 12 child-parent gene-positive pairs, with a mean difference of 10.8 +/- 3.3 years. The finding of leg weakness was especially common in older-onset affected family member with leg hyperreflexia. These results suggest that specific clinical signs and symptoms may be of value in differentiating individuals affected with SPG4 from family members with nonspecific neurological findings.Copyright 2004 Movement Disorder Society JF - Movement disorders : official journal of the Movement Disorder Society AU - Nicholas, Anthony P AU - O'Hearn, Elizabeth AU - Holmes, Susan E AU - Chen, Dung-Tsa AU - Margolis, Russell L AD - Department of Neurology, University of Alabama at Birmingham and the Birmingham Veterans Administration Medical Center, Birmingham, Alabama 35249-7340, USA. nicholas@uab.edu Y1 - 2004/06// PY - 2004 DA - Jun 2004 SP - 641 EP - 648 VL - 19 IS - 6 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - *Adenosine Triphosphatases: genetics KW - Adult KW - *Calcium-Binding Proteins: genetics KW - DNA Repeat Expansion: genetics KW - Female KW - Genetic Linkage: genetics KW - Humans KW - Male KW - Middle Aged KW - *Paraparesis, Spastic: genetics KW - *Paraparesis, Spastic: physiopathology KW - Pedigree KW - *Point Mutation: genetics KW - Polymerase Chain Reaction KW - Videotape Recording UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85389865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Clinical+signs+and+symptoms+in+a+large+hereditary+spastic+paraparesis+pedigree+with+a+novel+spastin+mutation.&rft.au=Nicholas%2C+Anthony+P%3BO%27Hearn%2C+Elizabeth%3BHolmes%2C+Susan+E%3BChen%2C+Dung-Tsa%3BMargolis%2C+Russell+L&rft.aulast=Nicholas&rft.aufirst=Anthony&rft.date=2004-06-01&rft.volume=19&rft.issue=6&rft.spage=641&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Suffocation in motor vehicle crashes. AN - 71963385; 15166758 AB - Because death from suffocation in traffic fatalities has not been well described, we delineated the clinical, circumstantial, and autopsy findings associated with suffocation in a series of motor vehicle crashes. Medical examiner case files from a 5-year period were reviewed. Scene investigation, autopsy, toxicology, and first-responder reports were examined. Crash descriptions were reviewed, including vehicle type, mechanism of crash, response time, restraint use, occupant ejection, and victim position in cabins of vehicles. Mechanisms of suffocation, including torso compression, inversion, neck flexion, facial occlusion, and blood aspiration, were determined for each case. The files were searched for factors relevant to the diagnosis of suffocation, namely, cerebral concussion, alcohol intoxication, obesity, petechiae, lung weights as a proxy for livor, natural disease, and impact wounds. Twenty-nine traffic fatality cases were identified in which suffocation caused death. In 26, suffocation mechanisms were solely responsible for death. In 3, death was caused by suffocation in combination with other mechanisms. Twenty-five subjects were occupants of vehicles with cabins and 4 were motorcycle riders. The most common mechanism of suffocation was torso compression. Most subjects had either multiple mechanisms of suffocation or a single mechanism acting in concert with concussion or alcohol intoxication. Concussion and intoxication were common, with one or both present in 20 subjects, including all of those with blood aspiration. Petechiae were frequent but were found consistently only among those with inversion. Cutaneous chest petechiae were associated with inversion and torso compression. Lung weights were highest among those with blood aspiration and lowest among those with inversion. Body mass index was highest among those with inversion, suggesting that obesity could be a risk factor for this mechanism. JF - The American journal of forensic medicine and pathology AU - Vega, Russell S AU - Adams, Vernard I AD - Department of Pathology, University of South Florida, Tampa, Florida, USA. russell.vega@med.va.gov Y1 - 2004/06// PY - 2004 DA - June 2004 SP - 101 EP - 107 VL - 25 IS - 2 SN - 0195-7910, 0195-7910 KW - Index Medicus KW - Alcoholic Intoxication -- pathology KW - Inhalation KW - Thoracic Injuries -- complications KW - Humans KW - Alcoholic Intoxication -- complications KW - Facial Injuries -- pathology KW - Lung -- pathology KW - Body Mass Index KW - Organ Size KW - Florida KW - Thoracic Injuries -- pathology KW - Compressive Strength -- physiology KW - Blood KW - Neck Injuries -- pathology KW - Adult KW - Facial Injuries -- complications KW - Middle Aged KW - Purpura -- pathology KW - Neck Injuries -- complications KW - Time Factors KW - Thoracic Injuries -- physiopathology KW - Male KW - Female KW - Asphyxia -- physiopathology KW - Asphyxia -- pathology KW - Asphyxia -- etiology KW - Accidents, Traffic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71963385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+forensic+medicine+and+pathology&rft.atitle=Suffocation+in+motor+vehicle+crashes.&rft.au=Vega%2C+Russell+S%3BAdams%2C+Vernard+I&rft.aulast=Vega&rft.aufirst=Russell&rft.date=2004-06-01&rft.volume=25&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+forensic+medicine+and+pathology&rft.issn=01957910&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-07-22 N1 - Date created - 2004-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - V-erba homodimers mediate the potent dominant negative activity of v-erba on everted repeats. AN - 66755912; 15293789 AB - The oncoprotein v-erbA is a mutated form of TRalpha1 that is unable to bind thyroid hormone (T3). V-erbA homodimerizes or heterodimerizes with retinoid X receptor (RXR) on core motifs arranged as direct, everted, or inverted repeats (DRs, ERs, or IRs). We created a series of v-erbA mutants in order to obtain a better understanding of the role of v-erbA homodimers versus v-erbA-RXR heterodimers in the dominant negative activity of v-erbA on ERs (the most potent v-erbA response elements). We found that one of these mutants, v-erbA mutant E325A, is able to homodimerize but unable to heterodimerize with RXR on ERs. Our data also suggest that v-erbA homodimers interact preferentially with the corepressor NCoR over SMRT and that the interaction with corepressors is stronger with v-erbA homodimers over v-erbA-RXR heterodimers. Furthermore, functional studies showed that v-erbA homodimers rather than v-erbA-RXR heterodimers mediate the dominant negative activity of v-erbA on ERs. JF - Molecular biology reports AU - Zubkova, Inna AU - Subauste, Jose S AD - G. V Montgomery Veterans Administration Medical Center and Division of Endocrinology and Metabolism, University of Mississippi, Jackson, MS 39216, USA. Y1 - 2004/06// PY - 2004 DA - June 2004 SP - 131 EP - 137 VL - 31 IS - 2 SN - 0301-4851, 0301-4851 KW - Oncogene Proteins v-erbA KW - 0 KW - Repressor Proteins KW - Retinoid X Receptor alpha KW - Index Medicus KW - Point Mutation -- genetics KW - Animals KW - Retinoid X Receptor alpha -- chemistry KW - COS Cells KW - Helix-Loop-Helix Motifs -- genetics KW - Dimerization KW - Humans KW - Repressor Proteins -- metabolism KW - Amino Acid Sequence KW - Retinoid X Receptor alpha -- metabolism KW - Repressor Proteins -- chemistry KW - Mutagenesis, Site-Directed KW - Binding, Competitive KW - Cercopithecus aethiops KW - Molecular Sequence Data KW - Response Elements KW - Oncogene Proteins v-erbA -- chemistry KW - Repetitive Sequences, Nucleic Acid KW - Oncogene Proteins v-erbA -- genetics KW - Oncogene Proteins v-erbA -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66755912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+biology+reports&rft.atitle=V-erba+homodimers+mediate+the+potent+dominant+negative+activity+of+v-erba+on+everted+repeats.&rft.au=Zubkova%2C+Inna%3BSubauste%2C+Jose+S&rft.aulast=Zubkova&rft.aufirst=Inna&rft.date=2004-06-01&rft.volume=31&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Molecular+biology+reports&rft.issn=03014851&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-01-24 N1 - Date created - 2004-08-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Panic disorder: psychopathology, medical management and dental implications. AN - 66731091; 15270162 AB - This article reviews the clinical features, epidemiology, pathophysiology, dental findings, and dental and medical management of the care of patients with panic disorder, or PD. The authors conducted a MEDLINE search for the period 1998 through 2003, using the key term "panic disorder" to define the pathophysiology of the disorder, its epidemiology and dental implications. The articles they selected for further review included those published in peer-reviewed journals. PD is a common and debilitating psychiatric disease in which a person experiences sudden and unpredictable panic attacks, or PAs, with symptoms of overwhelming anxiety, chest pain, palpitations and shortness of breath. Persistent concern about having another attack and worry that it may indicate a heart attack or "going crazy" impairs the person's social, family and working lives. Frequently accompanying the disorder is agoraphobia, depression and mitral valve prolapse, or MVP. In patients with PD, the prevalence of dental disease may be extensive because of the xerostomic effects of psychiatric medications used to treat it. Dental treatment consists of preventive dental education and prescribing saliva substitutes and anticaries agents. Precautions must be taken when prescribing or administering analgesics, antibiotics or sedative agents that may have an adverse interaction with the psychiatric medications. Because there is a connection between PAs and MVP, the dentist needs to consult with the patient's physician to determine the presence of MVP and whether there is associated mitral valve regurgitation. Patients with MVP and accompanying mitral valve regurgitation require prophylactic antibiotics when undergoing dental procedures known to cause a bacteremia and heightened risk of endocarditis. JF - Journal of the American Dental Association (1939) AU - Friedlander, Arthur H AU - Marder, Stephen R AU - Sung, Eric C AU - Child, John S AD - VA Greater Los Angeles Healthcare System, Calif 90073, USA. arthur.friedlander@med.va.gov Y1 - 2004/06// PY - 2004 DA - June 2004 SP - 771 EP - 8; quiz 796-7 VL - 135 IS - 6 SN - 0002-8177, 0002-8177 KW - Anti-Anxiety Agents KW - 0 KW - Serotonin Uptake Inhibitors KW - Benzodiazepines KW - 12794-10-4 KW - Dentistry KW - Index Medicus KW - Drug Interactions KW - Antibiotic Prophylaxis -- utilization KW - Xerostomia -- chemically induced KW - Benzodiazepines -- adverse effects KW - Mitral Valve Prolapse -- etiology KW - Behavior Therapy KW - Humans KW - Anti-Anxiety Agents -- adverse effects KW - Serotonin Uptake Inhibitors -- adverse effects KW - Dental Care for Chronically Ill -- methods KW - Panic Disorder -- physiopathology KW - Panic Disorder -- epidemiology KW - Panic Disorder -- therapy KW - Panic Disorder -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66731091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Panic+disorder%3A+psychopathology%2C+medical+management+and+dental+implications.&rft.au=Friedlander%2C+Arthur+H%3BMarder%2C+Stephen+R%3BSung%2C+Eric+C%3BChild%2C+John+S&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2004-06-01&rft.volume=135&rft.issue=6&rft.spage=771&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-23 N1 - Date created - 2004-07-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Am Dent Assoc. 2004 Aug;135(8):1086; author reply 1086 [15387046] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of frequency modulation (FM) transmitter microphone directivity on speech perception in noise. AN - 66701342; 15248800 AB - Frequency modulation (FM) technology can significantly improve the speech perception ability of individuals with sensorineural hearing loss (SNHL) in background noise. Previous investigations have demonstrated that the microphone design of the FM transmitter can have a significant impact on this improved speech perception. The purpose of this investigation was to compare 3 types of FM transmitter microphone designs: (a) wide angle (omnidirectional microphone), which amplifies sounds coming from all directions around the microphone equally; (b) zoom (1 directional microphone), which provides less amplification to signals coming from the rear, and (c) superzoom (2 directional microphones), which provides less amplification to signals originating from the rear and the sides. Fifteen adults with bilateral slight to moderately severe SNHL participated. Speech perception was assessed using the Hearing in Noise Test (M. Nilsson, S. Soli, and J. Sullivan, 1994). Speech spectrum shaped noise served as the noise competition. Results revealed that the best speech perception in noise was obtained when the FM transmitter was used in the zoom setting. The poorest performance was obtained when the FM transmitter was in the wide-angle mode. The clinical implications of these results are discussed. JF - American journal of audiology AU - Lewis, M Samantha AU - Crandell, Carl C AU - Kreisman, Nicole V AD - University of Florida, Gainesville, FL, USA. Michele.Lewis3@med.va.gov Y1 - 2004/06// PY - 2004 DA - June 2004 SP - 16 EP - 22 VL - 13 IS - 1 SN - 1059-0889, 1059-0889 KW - Index Medicus KW - Environment KW - Equipment Design KW - Analysis of Variance KW - Aged, 80 and over KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Male KW - Female KW - Speech Perception KW - Noise KW - Hearing Aids KW - Hearing Loss, Sensorineural -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66701342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+audiology&rft.atitle=Effects+of+frequency+modulation+%28FM%29+transmitter+microphone+directivity+on+speech+perception+in+noise.&rft.au=Lewis%2C+M+Samantha%3BCrandell%2C+Carl+C%3BKreisman%2C+Nicole+V&rft.aulast=Lewis&rft.aufirst=M&rft.date=2004-06-01&rft.volume=13&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=American+journal+of+audiology&rft.issn=10590889&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-02-07 N1 - Date created - 2004-07-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Heme oxygenase in experimental intracerebral hemorrhage: the benefit of tin-mesoporphyrin. AN - 66649519; 15217087 AB - The prognosis of intracerebral hemorrhage (ICH) is unfavorable. Beyond immediate mass effect and tissue destruction, ICHs cause additional neuronal loss in a "perifocal reactive zone." Heme in ICH induces heme oxygenase-1 (HO-1), and the action of this enzyme on heme yields ferrous iron, biliverdin, and carbon monoxide. Iron is ultimately converted to ferritin and hemosiderin. Free iron is tissue-toxic, and inhibition of HO-1 should provide protection against additional damage. Experimental ICHs were made in adult rabbits by the stereotaxic injection of autologous blood, and the induction of HO-1 and increase in ferritin were followed by confocal immunofluorescence microscopy. Heme diffused rapidly through perivascular spaces, and HO-1 reaction product first occurred in perivascular cells and microglia. At this stage, HO-1 and ferritin showed extensive colocalization. As ICH resolution progressed, HO-1 immunoreactivity faded while ferritin and hemosiderin continued to accumulate. This process was accompanied by a gradient of destruction of neuronal cell bodies and dendrites in the perifocal reactive zone. In an effort to inhibit HO-1, repeated intravenous injections of tin-mesoporphyrin IX (SnMP) were given to ICH-bearing rabbits. The ICH disrupted the blood-brain barrier sufficiently to allow SnMP to enter the brain in pharmacological amounts, and the metalloporphyrin provided significant protection against neuronal loss. JF - Journal of neuropathology and experimental neurology AU - Koeppen, Arnulf H AU - Dickson, Andrew C AU - Smith, Joanne AD - Neurology Service, VA Medical Center, Albany, New York 12208, USA. arnulf.koeppen@med.va.gov Y1 - 2004/06// PY - 2004 DA - June 2004 SP - 587 EP - 597 VL - 63 IS - 6 SN - 0022-3069, 0022-3069 KW - Enzyme Inhibitors KW - 0 KW - Metalloporphyrins KW - tin mesoporphyrin KW - 0KAE1U0G7Q KW - Heme Oxygenase (Decyclizing) KW - EC 1.14.14.18 KW - Index Medicus KW - Animals KW - Enzyme Inhibitors -- therapeutic use KW - Enzyme Inhibitors -- pharmacology KW - Rabbits KW - Male KW - Heme Oxygenase (Decyclizing) -- antagonists & inhibitors KW - Metalloporphyrins -- pharmacology KW - Heme Oxygenase (Decyclizing) -- metabolism KW - Cerebral Hemorrhage -- drug therapy KW - Metalloporphyrins -- therapeutic use KW - Cerebral Hemorrhage -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66649519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuropathology+and+experimental+neurology&rft.atitle=Heme+oxygenase+in+experimental+intracerebral+hemorrhage%3A+the+benefit+of+tin-mesoporphyrin.&rft.au=Koeppen%2C+Arnulf+H%3BDickson%2C+Andrew+C%3BSmith%2C+Joanne&rft.aulast=Koeppen&rft.aufirst=Arnulf&rft.date=2004-06-01&rft.volume=63&rft.issue=6&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuropathology+and+experimental+neurology&rft.issn=00223069&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-07-08 N1 - Date created - 2004-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Safety of 25- and 50-mg capsules in the initiation of zonisamide therapy in patients with epilepsy: an uncontrolled, open-label study. AN - 66637854; 15200740 AB - This study was designed to assess the safety of 25- and 50-mg dosage strengths of zonisamide for initial titration in patients with epilepsy. This phase 3, multicenter, open-label, uncontrolled study conducted at 26 study sites in the United States included male and female patients with epilepsy >or= 12 years of age. After a screening visit, subjects began zonisamide therapy at a dosage depending on their body weight. Zonisamide was titrated to 100 mg/day. At the study's conclusion, information regarding adverse events (AEs) and body weight was recorded. One hundred forty-three subjects enrolled and received at least one zonisamide dose. Of these subjects, 125 reached at least the 100-mg dosage before terminating the study. Eighty-two subjects (57.3%) experienced at least one AE. Most commonly reported AEs included headache, somnolence, asthenia, rhinitis, nausea, and rash. No significant change in patient body weight was noted during the study (95% confidence interval: -0.1, 0.6). Study limitations include the open-label design and the lack of direct comparison between lower (25- and 50-mg) and higher (100-mg) starting dosages. Despite these limitations, the 25- and 50-mg zonisamide dosage formulations were well tolerated in this study. JF - Current medical research and opinion AU - Uthman, Basim M AU - Miller, G Steven AU - Montouris, Georgia AU - James, Steven P AU - Anthony, Stacy AU - Zonisamide 501 Study Group AD - Malcom Randall Department of Veterans Affairs Medical Center; University of Florida College of Medicine and the McKnight Brain Institute, Gainesville, FL 32608, USA. basim.uthman@med.va.gov ; Zonisamide 501 Study Group Y1 - 2004/06// PY - 2004 DA - June 2004 SP - 837 EP - 842 VL - 20 IS - 6 SN - 0300-7995, 0300-7995 KW - Anticonvulsants KW - 0 KW - Isoxazoles KW - zonisamide KW - 459384H98V KW - Index Medicus KW - United States KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Male KW - Female KW - Isoxazoles -- adverse effects KW - Epilepsy -- drug therapy KW - Isoxazoles -- administration & dosage KW - Isoxazoles -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66637854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+medical+research+and+opinion&rft.atitle=Safety+of+25-+and+50-mg+capsules+in+the+initiation+of+zonisamide+therapy+in+patients+with+epilepsy%3A+an+uncontrolled%2C+open-label+study.&rft.au=Uthman%2C+Basim+M%3BMiller%2C+G+Steven%3BMontouris%2C+Georgia%3BJames%2C+Steven+P%3BAnthony%2C+Stacy%3BZonisamide+501+Study+Group&rft.aulast=Uthman&rft.aufirst=Basim&rft.date=2004-06-01&rft.volume=20&rft.issue=6&rft.spage=837&rft.isbn=&rft.btitle=&rft.title=Current+medical+research+and+opinion&rft.issn=03007995&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-09-21 N1 - Date created - 2004-06-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Veterans Seeking Disability Benefits for Post-Traumatic Stress Disorder: Who Applies and the Self-Reported Meaning of Disability Compensation AN - 61433054; 200405065 AB - Assumptions about the characteristics & motivations of individuals pursuing disability status are well known. However, policy, programming & interventions need to be based on information about the actual sociodemographic characteristics of disabled individuals, as well as their goals in seeking disability status. In this study, we focus on veterans seeking disability compensation for post-traumatic stress disorder (PTSD) from the United States Department of Veterans Affairs. We present information on their life circumstances & their self-reported reasons for valuing the obtainment of veterans' disability status on the basis of PTSD. There was considerable variability in the background of veterans seeking disability status on the basis of PTSD. Of concern, only about half of these individuals were receiving any mental health treatment at the time of application. Most claimants reported seeking disability compensation for symbolic reasons, especially for acknowledgement, validation & relief from self-blame. Reasons having to do with improved finances were less frequently endorsed, although the importance of obtaining improved solvency through disability status decreased as income increased. The sense of investment in obtaining a sense of self-acceptance & acceptance from others through disability status varied by sociodemographic variables. Overall, findings suggest that individuals seeking disability benefits may have unmet mental health care needs, & that policy makers, investigators & providers should consider material benefit as one of many possible reasons for engaging in a disability compensation system. 3 Tables, 69 References. [Copyright 2004 Elsevier Ltd.] JF - Social Science & Medicine AU - Sayer, Nina A AU - Spoont, Michele AU - Nelson, Dave AD - Center Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, MN nina.sayer@med.va.gov Y1 - 2004/06// PY - 2004 DA - June 2004 SP - 2133 EP - 2143 VL - 58 IS - 11 SN - 0277-9536, 0277-9536 KW - Veterans KW - Midwestern States KW - Disability Recipients KW - United States of America KW - Posttraumatic Stress Disorder KW - Benefits KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61433054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Veterans+Seeking+Disability+Benefits+for+Post-Traumatic+Stress+Disorder%3A+Who+Applies+and+the+Self-Reported+Meaning+of+Disability+Compensation&rft.au=Sayer%2C+Nina+A%3BSpoont%2C+Michele%3BNelson%2C+Dave&rft.aulast=Sayer&rft.aufirst=Nina&rft.date=2004-06-01&rft.volume=58&rft.issue=11&rft.spage=2133&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2003.08.009 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Number of references - 69 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Veterans; Posttraumatic Stress Disorder; Disability Recipients; Benefits; Midwestern States; United States of America DO - http://dx.doi.org/10.1016/j.socscimed.2003.08.009 ER - TY - JOUR T1 - A report from the international consensus on diagnosing and treating the infected diabetic foot AN - 21280312; 11313736 AB - In persons with diabetes, foot infection, that is, invasion and multiplication of microorganisms in tissues accompanied by tissue destruction or a host inflammatory response, usually begins with skin trauma or ulceration [1]. While most foot infections remain superficial, they can spread to subcutaneous tissues, including muscle, joints, and bone. Many diabetic foot ulcers eventuate in an amputation; infection plays a role in approximately 60% of cases [2-4]. Neuropathy is the main factor leading to skin breaks, while arterial perfusion largely affects infection outcome. Among the factors predisposing diabetic patients to foot infections are ill-defined immunological perturbations [5][6]; foot anatomy may foster proximal spread of infection and ischemic necrosis [7][8]. JF - Diabetes - Metabolism: Research and Reviews (Print Edition) AU - Lipsky, Benjamin A AD - VA Puget Sound HCS, S-111 GIMC, 1660 S. Columbian Way, Seattle, Washington, 98108, USA, Benjamin.Lipsky@med.va.gov Y1 - 2004/06// PY - 2004 DA - Jun 2004 SP - S68 EP - S77 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 20 IS - S1 SN - 1520-7552, 1520-7552 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Skin KW - Perfusion KW - Amputation KW - Joint diseases KW - Muscles KW - Ischemia KW - Infection KW - Inflammation KW - Trauma KW - Bone KW - Diabetes mellitus KW - Necrosis KW - Ulcers KW - Microorganisms KW - Foot KW - Neuropathy KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21280312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+-+Metabolism%3A+Research+and+Reviews+%28Print+Edition%29&rft.atitle=A+report+from+the+international+consensus+on+diagnosing+and+treating+the+infected+diabetic+foot&rft.au=Lipsky%2C+Benjamin+A&rft.aulast=Lipsky&rft.aufirst=Benjamin&rft.date=2004-06-01&rft.volume=20&rft.issue=S1&rft.spage=S68&rft.isbn=&rft.btitle=&rft.title=Diabetes+-+Metabolism%3A+Research+and+Reviews+%28Print+Edition%29&rft.issn=15207552&rft_id=info:doi/10.1002%2Fdmrr.453 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Perfusion; Skin; Amputation; Muscles; Joint diseases; Ischemia; Infection; Trauma; Inflammation; Diabetes mellitus; Bone; Necrosis; Ulcers; Foot; Microorganisms; Neuropathy DO - http://dx.doi.org/10.1002/dmrr.453 ER - TY - JOUR T1 - HB-107, a nonbacteriostatic fragment of the antimicrobial peptide cecropin B, accelerates murine wound repair AN - 19520144; 6590098 AB - Antimicrobial peptides are essential to innate host defense as effectors of pathogen clearance and can modify host cell behaviors to promote wound repair. While these two functions appear interrelated, it is unclear whether the ability to aid in wound repair requires inherent antimicrobial function. We hypothesized that the influence of antimicrobial peptides on wound repair is not dependent on antimicrobial function. To explore this, we analyzed the microbial killing activity of peptide fragments and correlated this with the ability to influence wound repair in mice. HB-107, a peptide lacking antimicrobial activity and originally derived from the antimicrobial cecropin B, showed up to 64 percent improvement in wound repair compared to scrambled peptide and vehicle controls, an effect comparable to treatment with recombinant human platelet-derived growth factor-BB (formulated as Regranex super(TM)). Wounds treated with HB-107 showed keratinocyte hyperplasia and increased leukocyte infiltration. Furthermore, HB-107 stimulated interleukin-8 secretion from cultured endothelial cells, an effect that may explain the increase in leukocyte migration. These findings confirm that antimicrobial peptides can function as effectors of cutaneous wound repair. Moreover, this study furthers our understanding of antimicrobial peptides by showing that their wound repair properties can be independent of antimicrobial function. JF - Wound Repair and Regeneration AU - Lee, Phillip HA AU - Rudisill, Jennifer A AU - Lin, Kenneth H AU - Zhang, Lijuan AU - Harris, Scott M AU - Falla, Timothy J AU - Gallo, Richard L AD - Richard L. Gallo, MD, PhD, Dermatology Section, Veterans Administration Hospital, 3350 La Jolla Village Dr. Mail code 151, San Diego, CA 92161, rgallo@vapop.ucsd.edu Y1 - 2004/06// PY - 2004 DA - Jun 2004 SP - 351 EP - 358 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 12 IS - 3 SN - 1067-1927, 1067-1927 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Endothelial cells KW - Leukocyte migration KW - Cecropin KW - Hyperplasia KW - Antimicrobial activity KW - Wound healing KW - Pathogens KW - Keratinocytes KW - Antimicrobial peptides KW - Interleukin 8 KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19520144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wound+Repair+and+Regeneration&rft.atitle=HB-107%2C+a+nonbacteriostatic+fragment+of+the+antimicrobial+peptide+cecropin+B%2C+accelerates+murine+wound+repair&rft.au=Lee%2C+Phillip+HA%3BRudisill%2C+Jennifer+A%3BLin%2C+Kenneth+H%3BZhang%2C+Lijuan%3BHarris%2C+Scott+M%3BFalla%2C+Timothy+J%3BGallo%2C+Richard+L&rft.aulast=Lee&rft.aufirst=Phillip&rft.date=2004-06-01&rft.volume=12&rft.issue=3&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Wound+Repair+and+Regeneration&rft.issn=10671927&rft_id=info:doi/10.1111%2Fj.1067-1927.2004.012303.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - SuppNotes - Figures, 4; tables, 2; references, 28. N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Leukocyte migration; Endothelial cells; Cecropin; Antimicrobial activity; Hyperplasia; Wound healing; Keratinocytes; Pathogens; Antimicrobial peptides; Interleukin 8 DO - http://dx.doi.org/10.1111/j.1067-1927.2004.012303.x ER - TY - JOUR T1 - Use of auditory brainstem responses for the early detection of ototoxicity from aminoglycosides or chemotherapeutic drugs AN - 18032086; 5983446 AB - Effective objective HF (high-frequency) testing methodology provides for the early detection of ototoxic hearing loss because it typically progresses from high to low frequencies. Such early detection is considered necessary to prevent hearing loss from progressing into the frequency range important for understanding speech. Objective tests must be reliable, sensitive to hearing change, and time efficient. Auditory brainstem responses (ABRs) appear well suited to this task; however, current ABR techniques have limitations. Conventional clicks stimulate middle (1-4 kHz) rather than high frequencies (>8 kHz). Responses to HF tone bursts require considerable recording time. We hypothesized that using HF band-limited clicks (HF clicks) could overcome these limitations. Two different HF clicks, with band-widths of 8-14 kHz were used to elicit ABRs. The current study compared responses among these stimuli. The results demonstrate the reliability of HF-click responses and of tone bursts presented in trains. JF - Journal of Rehabilitation Research and Development AU - Mitchell, C R AU - Ellingson, R M AU - Henry, JA AU - Fausti, SA AD - 3710 SW United States Veterans Hospital Road (R&D-NCRAR), Portland, OR 97207, USA, stephen.fausti@med.va.gov Y1 - 2004/06// PY - 2004 DA - Jun 2004 SP - 373 EP - 382 VL - 41 IS - 3A SN - 0748-7711, 0748-7711 KW - Toxicology Abstracts KW - Ototoxicity KW - Detection KW - Hearing KW - Toxicity testing KW - Drugs KW - Aminoglycoside antibiotics KW - X 24221:Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18032086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Use+of+auditory+brainstem+responses+for+the+early+detection+of+ototoxicity+from+aminoglycosides+or+chemotherapeutic+drugs&rft.au=Mitchell%2C+C+R%3BEllingson%2C+R+M%3BHenry%2C+JA%3BFausti%2C+SA&rft.aulast=Mitchell&rft.aufirst=C&rft.date=2004-06-01&rft.volume=41&rft.issue=3A&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Ototoxicity; Detection; Hearing; Drugs; Toxicity testing; Aminoglycoside antibiotics ER - TY - JOUR T1 - Isolated Pulmonic Valve Infective Endocarditis: A Persistent Challenge AN - 17785765; 5968179 AB - Isolated pulmonic valve infective endocarditis is an uncommon clinical entity. We report our experience with three patients diagnosed with pulmonic valve endocarditis from our institution. Two cases were caused by Enterococcus faecalis (one was resistant to vancomycin) and one by coagulase-negative staphylococci (CNS). One of the cases of isolated pulmonic valve endocarditis due to the E. faecalis was nosocomially acquired; the case of CNS pulmonic valve endocarditis was dialysis catheter related. Each patient with isolated pulmonic valve endocarditis presented with hypotension and interstitial pulmonary infiltrates. Two patients were treated with linezolid. Both vancomycinresistant enterococci (VRE) and CNS were eliminated from blood cultures on linezolid therapy. The challenges inherent in the management of pulmonic valve endocarditis mandate the development of individual patient-specific guidelines. JF - Infection AU - Hamza, N AU - Ortiz, J AU - Bonomo, R A AD - Infectious Disease Section, Medical and Research Services, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Blvd., Cleveland, Ohio 44106, USA, robert.bonomo@med.va.gov Y1 - 2004/06// PY - 2004 DA - Jun 2004 SP - 170 EP - 175 VL - 32 IS - 3 SN - 0300-8126, 0300-8126 KW - Microbiology Abstracts B: Bacteriology KW - Blood culture KW - Hypotension KW - Central nervous system KW - Dialysis KW - Lung KW - Catheters KW - Enterococcus faecalis KW - Vancomycin KW - Linezolid KW - Endocarditis KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17785765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection&rft.atitle=Isolated+Pulmonic+Valve+Infective+Endocarditis%3A+A+Persistent+Challenge&rft.au=Hamza%2C+N%3BOrtiz%2C+J%3BBonomo%2C+R+A&rft.aulast=Hamza&rft.aufirst=N&rft.date=2004-06-01&rft.volume=32&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Infection&rft.issn=03008126&rft_id=info:doi/10.1007%2Fs15010-004-3022-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Enterococcus faecalis; Endocarditis; Central nervous system; Linezolid; Hypotension; Blood culture; Vancomycin; Catheters; Lung; Dialysis DO - http://dx.doi.org/10.1007/s15010-004-3022-3 ER - TY - JOUR T1 - In Vitro Activities of Garenoxacin and Levofloxacin against Chlamydia pneumoniae Are Not Affected by Presence of Mycoplasma DNA AN - 17705662; 5917719 AB - We studied 20 Chlamydia pneumoniae isolates obtained from respiratory sites and atheroma tissue of patients from various geographic areas to determine the susceptibilities of these isolates to a new des-fluoroquinolone, garenoxacin, and to levofloxacin. In addition, we assessed the cultures with these isolates by PCR for the presence or absence of Mycoplasma sp. DNA. Both the MIC at which 90% of isolates are inhibited (MIC sub(90)) and the minimal bactericidal concentration at which 90% of isolates are killed (MBC sub(90)) for garenoxacin were 0.06 mu g/ml, and both the MIC sub(90) and the MBC sub(90) for levofloxacin were 2.0 mu g/ml. The activity of garenoxacin against C. pneumoniae was 32-fold greater than that of levofloxacin. Mycoplasma sp. DNA was detected by PCR in 17 of 20 cultures. Mycoplasma amplicons from five Mycoplasma DNA-positive C. pneumoniae cultures were sequenced and found to represent four Mycoplasma species. Our data demonstrate that C. pneumoniae cultures frequently contain Mycoplasma DNA and that its presence in C. pneumoniae cultures does not appear to affect the susceptibility results for the two fluoroquinolones that we tested. JF - Antimicrobial Agents & Chemotherapy AU - Smith, R P AU - Baltch, AL AU - Ritz, W J AU - Carpenter, AN AU - Halse, T A AU - Bopp, L H AD - Infectious Disease Research, Infectious Disease Section (III D), Stratton VA Medical Center, Albany, NY 12208, aldona.baltch@med.va.gov Y1 - 2004/06// PY - 2004 DA - Jun 2004 SP - 2081 EP - 2084 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 48 IS - 6 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology KW - Culture KW - Fluoroquinolones KW - Levofloxacin KW - Drug resistance KW - Chlamydia pneumoniae KW - garenoxacin KW - Polymerase chain reaction KW - Minimum inhibitory concentration KW - Mycoplasma KW - Antimicrobial agents KW - J 02806:Quinones, quinolones and quinolines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17705662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+Vitro+Activities+of+Garenoxacin+and+Levofloxacin+against+Chlamydia+pneumoniae+Are+Not+Affected+by+Presence+of+Mycoplasma+DNA&rft.au=Smith%2C+R+P%3BBaltch%2C+AL%3BRitz%2C+W+J%3BCarpenter%2C+AN%3BHalse%2C+T+A%3BBopp%2C+L+H&rft.aulast=Smith&rft.aufirst=R&rft.date=2004-06-01&rft.volume=48&rft.issue=6&rft.spage=2081&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.48.6.2081-2084.2004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycoplasma; Chlamydia pneumoniae; Drug resistance; Culture; garenoxacin; Levofloxacin; Polymerase chain reaction; Fluoroquinolones; Antimicrobial agents; Minimum inhibitory concentration DO - http://dx.doi.org/10.1128/AAC.48.6.2081-2084.2004 ER - TY - JOUR T1 - Hippocampal dysfunction in Gulf War Syndrome. A proton MR spectroscopy study. AN - 71892707; 15120596 AB - The pathogenesis of Gulf War Syndrome (GWS) is not clearly understood. Data exist to suggest that GWS may originate from a combination of chronic fatigue and sensitivity to the exposure of exogenous agents. Since the head region of hippocampus is highly vascularized and thus vulnerable to toxic substances in circulation, we postulated that hippocampal impairment occurs in GWS. To test this, single volume localized in vivo proton MR spectroscopy (MRS) studies of the left and right hippocampi of consenting Gulf War veterans (N=15; 10 with GWS, and 5 without GWS) and control Vietnam veterans (N=6) were conducted in accordance with approved human study protocols. The N-acetyl aspartate (NAA) to creatine and choline to creatine ratios were computed from the spectra. The NAA/creatine ratio of the GWS group (N=10) was found to be significantly lower than that of the entire control group (N=11) or the unaffected GW control group (N=5). No laterality differences were observed among any of the three groups. The choline/creatine ratio of the GWS group was not different from that for either control group. To check the existence of any relationship between age and the NAA/creatine ratios, the entire study population was grouped into those below or above the median age (44.3 years). It was found that the NAA/Cre ratio of the younger group (only Gulf War veterans) was significantly lower than that of the older group. The lower NAA/creatine ratio for the GWS group points to the existence of hippocampal dysfunction. JF - Brain research AU - Menon, P Mohanakrishnan AU - Nasrallah, Henry A AU - Reeves, Roy R AU - Ali, Jeffrey A AD - Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216, USA. parekkat.mohanakrishnan@med.va.gov Y1 - 2004/05/29/ PY - 2004 DA - 2004 May 29 SP - 189 EP - 194 VL - 1009 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Aspartic Acid KW - 30KYC7MIAI KW - N-acetylaspartate KW - 997-55-7 KW - Creatine KW - MU72812GK0 KW - Choline KW - N91BDP6H0X KW - Index Medicus KW - Creatine -- metabolism KW - Analysis of Variance KW - Dominance, Cerebral -- physiology KW - Brain Chemistry KW - Humans KW - Choline -- metabolism KW - Veterans KW - Magnetic Resonance Spectroscopy -- methods KW - Adult KW - Middle Aged KW - Image Processing, Computer-Assisted KW - Female KW - Male KW - Aspartic Acid -- metabolism KW - Aspartic Acid -- analogs & derivatives KW - Persian Gulf Syndrome -- diagnosis KW - Hippocampus -- physiopathology KW - Persian Gulf Syndrome -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71892707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Hippocampal+dysfunction+in+Gulf+War+Syndrome.+A+proton+MR+spectroscopy+study.&rft.au=Menon%2C+P+Mohanakrishnan%3BNasrallah%2C+Henry+A%3BReeves%2C+Roy+R%3BAli%2C+Jeffrey+A&rft.aulast=Menon&rft.aufirst=P&rft.date=2004-05-29&rft.volume=1009&rft.issue=1-2&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-07-12 N1 - Date created - 2004-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Promotion of noise-induced hearing loss by chemical contaminants AN - 17983415; 5940150 AB - Recent studies have underscored the ability of a wide range of chemical agents to potentate noise-induced hearing loss. Given the ubiquitous nature of noise exposure particularly in many work settings, the high rate of noise-induced hearing loss, the limited degree to which auditory function can recover following damage to the inner ear, and the disparate chemical structures that appear capable of impairing hearing, this issue appears to have great public health significance. A compendium of chemicals known to potentiate noise induced hearing loss is presented along with a hypothesis that might explain at least one basis for potentiation of noise-induced hearing loss by certain chemical toxicants. The use of benchmark dose analysis to undertake a risk assessment for promotion of noise-induced hearing loss by both carbon monoxide and hydrogen cyanide is described. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Fechter, L D AD - Jerry Pettis Memorial Veterans Medical Center, Research Service (151), 11201 Benton Street, Loma Linda, CA 92357, USA, larry.fechter@med.va.gov Y1 - 2004/05/28/ PY - 2004 DA - 2004 May 28 SP - 727 EP - 740 VL - 67 IS - 8-10 SN - 1528-7394, 1528-7394 KW - man KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts; Risk Abstracts KW - Chemicals KW - Toxicants KW - Xenobiotics KW - Occupational exposure KW - Noise levels KW - Hearing loss KW - Working conditions KW - Reviews KW - Contaminants KW - R2 23080:Industrial and labor KW - P 7000:NOISE KW - X 24250:Reviews KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17983415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Promotion+of+noise-induced+hearing+loss+by+chemical+contaminants&rft.au=Fechter%2C+L+D&rft.aulast=Fechter&rft.aufirst=L&rft.date=2004-05-28&rft.volume=67&rft.issue=8-10&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390490428206 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Chemicals; Noise levels; Hearing loss; Toxicants; Occupational exposure; Working conditions; Reviews; Contaminants; Xenobiotics DO - http://dx.doi.org/10.1080/15287390490428206 ER - TY - JOUR T1 - Anemia in HIV infection: clinical impact and evidence-based management strategies. AN - 71960474; 15156485 AB - Anemia in human immunodeficiency virus (HIV)-infected patients can have serious implications, which vary from functional and quality-of-life decrements to an association with disease progression and decreased survival. In 2002, 16 members of the Anemia in HIV Working Group, an expert panel of physicians involved in the care of HIV-infected patients that met first in 1998, reconvened to assess new data and to translate these data into evidence-based treatment guidelines. The group reached consensus on the prevalence of anemia in the highly active antiretroviral therapy era; the risk factors that are independently associated with the development of anemia; the impact of anemia on quality of life, physical functioning, and survival; the impact of the treatment of hepatitis C virus coinfection on anemia in HIV-infected patients; evidence-based guidelines for treatment of anemia in HIV-infected patients, including the therapeutic role of epoetin alfa; and directions for future research. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Volberding, Paul A AU - Levine, Alexandra M AU - Dieterich, Douglas AU - Mildvan, Donna AU - Mitsuyasu, Ronald AU - Saag, Michael AU - Anemia in HIV Working Group AD - University of California, San Francisco, CA, USA. paul.volberding@med.va.gov ; Anemia in HIV Working Group Y1 - 2004/05/15/ PY - 2004 DA - 2004 May 15 SP - 1454 EP - 1463 VL - 38 IS - 10 KW - Anti-HIV Agents KW - 0 KW - Antiviral Agents KW - Recombinant Proteins KW - Erythropoietin KW - 11096-26-7 KW - Epoetin Alfa KW - 64FS3BFH5W KW - Index Medicus KW - Antiviral Agents -- therapeutic use KW - Antiretroviral Therapy, Highly Active -- adverse effects KW - Hepatitis C -- drug therapy KW - Humans KW - Erythropoietin -- therapeutic use KW - Anti-HIV Agents -- adverse effects KW - Quality of Life KW - Forecasting KW - Antiviral Agents -- adverse effects KW - Anemia -- psychology KW - HIV Infections -- complications KW - Anemia -- epidemiology KW - Anemia -- drug therapy KW - Anemia -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71960474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Anemia+in+HIV+infection%3A+clinical+impact+and+evidence-based+management+strategies.&rft.au=Volberding%2C+Paul+A%3BLevine%2C+Alexandra+M%3BDieterich%2C+Douglas%3BMildvan%2C+Donna%3BMitsuyasu%2C+Ronald%3BSaag%2C+Michael%3BAnemia+in+HIV+Working+Group&rft.aulast=Volberding&rft.aufirst=Paul&rft.date=2004-05-15&rft.volume=38&rft.issue=10&rft.spage=1454&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-07-22 N1 - Date created - 2004-05-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Infect Dis. 2004 Oct 1;39(7):1088-9 [15472874] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Can drug therapies improve language functions of individuals with aphasia? A review of the evidence. AN - 85381269; pmid-15118945 AB - The neurochemistry of language and the neuropharmacology of aphasia are two domains of cognitive neuroscience still in their infancy. In this article we review what is known about these two domains, especially with regard to treating aphasia with drugs. Selected neurotransmitters can improve language function in certain patients with aphasia. We discuss which neurotransmitters work for which language functions in which patients, and why.Copyright 2004 Thieme Medical Publishers, Inc. JF - Seminars in speech and language AU - Klein, Reva B AU - Albert, Martin L AD - Boston University School of Medicine, VA Boston Healthcare System, Boston, Massachusetts 02130, USA. RevaBKlein@Boston.VA.gov Y1 - 2004/05// PY - 2004 DA - May 2004 SP - 193 EP - 204 VL - 25 IS - 2 SN - 0734-0478, 0734-0478 KW - Index Medicus KW - National Library of Medicine KW - *Acetylcholine: therapeutic use KW - *Aphasia: drug therapy KW - Aphasia: physiopathology KW - *Catecholamines: therapeutic use KW - Dopamine: therapeutic use KW - Evaluation Studies as Topic KW - Humans KW - Norepinephrine: therapeutic use KW - *Serotonin: therapeutic use KW - Treatment Outcome KW - *gamma-Aminobutyric Acid: therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85381269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+speech+and+language&rft.atitle=Can+drug+therapies+improve+language+functions+of+individuals+with+aphasia%3F+A+review+of+the+evidence.&rft.au=Klein%2C+Reva+B%3BAlbert%2C+Martin+L&rft.aulast=Klein&rft.aufirst=Reva&rft.date=2004-05-01&rft.volume=25&rft.issue=2&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Seminars+in+speech+and+language&rft.issn=07340478&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Leflunomide. AN - 71973858; 15172042 AB - Leflunomide is a low-molecular weight, synthetic, oral agent specifically developed for immunosuppression. Because of activity in animal models, leflunomide was tested in rheumatoid arthritis(RA). These investigations have demonstrated that leflunomide reduces the clinical symptoms and signs of RA, improves health related quality of life, and retards structural damage. Leflunomide has been evaluated in RA patients as monotherapy and in combination with methotrexate. Close monitoring for adverse events with particular attention for monitoring liver enzymes for hepatic toxicity is important during treatment with leflunomide. JF - Rheumatic diseases clinics of North America AU - Cannon, Grant W AU - Kremer, Joel M AD - Division of Rheumatology, Department of Medicine, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132, USA. grant.cannon@med.va.gov Y1 - 2004/05// PY - 2004 DA - May 2004 SP - 295 EP - 309, vi VL - 30 IS - 2 SN - 0889-857X, 0889-857X KW - Antirheumatic Agents KW - 0 KW - Immunosuppressive Agents KW - Isoxazoles KW - leflunomide KW - G162GK9U4W KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Models, Animal KW - Drug Therapy, Combination KW - Drug Monitoring -- methods KW - Arthritis, Rheumatoid -- drug therapy KW - Liver -- pathology KW - Joints -- pathology KW - Liver -- drug effects KW - Humans KW - Clinical Trials as Topic KW - Joints -- drug effects KW - Methotrexate -- therapeutic use KW - Antirheumatic Agents -- pharmacology KW - Isoxazoles -- therapeutic use KW - Isoxazoles -- pharmacology KW - Immunosuppressive Agents -- therapeutic use KW - Antirheumatic Agents -- therapeutic use KW - Immunosuppressive Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71973858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rheumatic+diseases+clinics+of+North+America&rft.atitle=Leflunomide.&rft.au=Cannon%2C+Grant+W%3BKremer%2C+Joel+M&rft.aulast=Cannon&rft.aufirst=Grant&rft.date=2004-05-01&rft.volume=30&rft.issue=2&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Rheumatic+diseases+clinics+of+North+America&rft.issn=0889857X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-03 N1 - Date created - 2004-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Elevations in serum creatinine concentration: concerning or reassuring? AN - 71963440; 15162910 AB - The use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) has significantly reduced morbidity and mortality across the continuum of vascular disease. The utilization of these agents, however, remains suboptimal. The drugs are not prescribed in many patients because of concerns regarding their effects on renal function. Despite overwhelming evidence in favor of renoprotection, it is not uncommon for the glomerular filtration rate (GFR) to decrease shortly after starting treatment with an ACE inhibitor or ARB. This response is functional in nature and should be expected based on renal physiology and its dependence on the renin-angiotensin system to maintain GFR. Unfortunately, this phenomenon sometimes is viewed as an adverse effect or an indicator of underlying pathology. Although somewhat counterintuitive, early elevations in serum creatinine concentration are associated with improved long-term renal outcomes in patients with renal insufficiency and thus support, rather than condemn, continued treatment. Clinicians should be aware of the physiologic course associated with blockade of the renin-angiotensin system so that these agents will not be withheld unnecessarily. JF - Pharmacotherapy AU - Epstein, Benjamin J AD - Department of Pharmacy and Research, North Florida/South Georgia Veterans Health-System, Gainesville, Florida 32608, USA. benjamin.epstein@med.va.gov Y1 - 2004/05// PY - 2004 DA - May 2004 SP - 697 EP - 702; discussion 702-3 VL - 24 IS - 5 SN - 0277-0008, 0277-0008 KW - Angiotensin Receptor Antagonists KW - 0 KW - Angiotensin-Converting Enzyme Inhibitors KW - Creatinine KW - AYI8EX34EU KW - Index Medicus KW - Glomerular Filtration Rate KW - Humans KW - Acute Kidney Injury -- chemically induced KW - Homeostasis -- drug effects KW - Angiotensin-Converting Enzyme Inhibitors -- adverse effects KW - Renin-Angiotensin System -- drug effects KW - Creatinine -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71963440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Elevations+in+serum+creatinine+concentration%3A+concerning+or+reassuring%3F&rft.au=Epstein%2C+Benjamin+J&rft.aulast=Epstein&rft.aufirst=Benjamin&rft.date=2004-05-01&rft.volume=24&rft.issue=5&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-17 N1 - Date created - 2004-05-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Pharmacotherapy. 2003 Sep;23(9):1199-204 [14524653] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Utilization of zonisamide in patients with chronic pain or epilepsy refractory to other treatments: a retrospective, open label, uncontrolled study in a VA hospital. AN - 71915782; 15140322 AB - Zonisamide (1,2-benzisoxazole-3-methanesulfonamide) is a novel anti-seizure medication approved for use in the United States as adjunct therapy in the treatment of partial seizures in adults with epilepsy. It has also been used to treat other conditions including intractable pain. The aim of this study was to determine the usefulness of zonisamide in patients whose seizures were not controlled after having been treated with at least three other currently available anticonvulsant medications or in patients whose pain control was suboptimal despite the use of commonly used drug regimens. This was a retrospective study documenting the efficacy of zonisamide in 48 consecutive patients who presented at an outpatient neurology clinic at a Veterans Administration hospital. The patients were diagnosed with refractory partial seizures (n = 21) or a variety of intractable neuropathic pain syndromes (n = 27). Sixteen out of 21 seizure patients (76%) experienced a 50% or greater reduction in seizure frequency when zonisamide (100-200 mg daily) was added to their existing anticonvulsant medication regimen. Of 27 patients with neuropathic pain, 17 (59%) responded to zonisamide, reporting subjective reduction in pain by at least 50%. The most common adverse events were gastrointestinal upset, somnolence, and one case of skin rash. In this study, zonisamide appeared to be an effective adjunct therapy in the treatment of partial seizures in adults who continued to experience frequent episodes while taking other anticonvulsant medications, and in adults whose neuropathic pain was not well controlled with analgesics. These promising results must be tempered by the fact that this investigation included a small patient population in an uncontrolled study design. Further research into the efficacy and tolerability of zonisamide in these areas is warranted. JF - Current medical research and opinion AU - Hasegawa, Hisanori AD - Aleda E. Lutz Saginaw Veterans Administration Medical Center, Saginaw, MI 48602, USA. hisanori.hasegawa@med.va.gov Y1 - 2004/05// PY - 2004 DA - May 2004 SP - 577 EP - 580 VL - 20 IS - 5 SN - 0300-7995, 0300-7995 KW - Anticonvulsants KW - 0 KW - Isoxazoles KW - zonisamide KW - 459384H98V KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Treatment Outcome KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Chronic Disease KW - Male KW - Pain -- etiology KW - Pain -- drug therapy KW - Isoxazoles -- adverse effects KW - Epilepsy -- complications KW - Anticonvulsants -- adverse effects KW - Epilepsy -- drug therapy KW - Anticonvulsants -- therapeutic use KW - Isoxazoles -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71915782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+medical+research+and+opinion&rft.atitle=Utilization+of+zonisamide+in+patients+with+chronic+pain+or+epilepsy+refractory+to+other+treatments%3A+a+retrospective%2C+open+label%2C+uncontrolled+study+in+a+VA+hospital.&rft.au=Hasegawa%2C+Hisanori&rft.aulast=Hasegawa&rft.aufirst=Hisanori&rft.date=2004-05-01&rft.volume=20&rft.issue=5&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=Current+medical+research+and+opinion&rft.issn=03007995&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-09-16 N1 - Date created - 2004-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - SSRIs do not cause affective blunting in healthy elderly volunteers. AN - 71903963; 15126234 AB - This study was undertaken to evaluate the effects of selective serotonin reuptake inhibitors (SSRIs) on affective experience in healthy older adults. After 1 week of observation, normal elderly volunteers (age range: 65-84 years) were given placebo, paroxetine (10 mg-40 mg/day), or sertraline (50 mg-150 mg/day) for 3 weeks in a double-blind study. Paroxetine- and sertraline-treated subjects were analyzed together as the SSRI group (N=30). Volunteers were assessed weekly and recorded mood and events in a daily diary each evening. All data were analyzed with mixed-effects random-regression models. There were significant relationships between daily affect and events reported in the daily diary for the sample as a whole, with no differences between groups in mean slopes of positive or negative affect across the length of the study. There were no differences between groups in affective variability. However, the SSRI group, but not the placebo group, demonstrated a significant drug-dependent decrease in negative affect related to negative events. There were no other observed group differences on any other measure. Interpreting the results conservatively, they demonstrate that SSRIs are not associated with affective toxicity in elderly persons. JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry AU - Furlan, Patricia M AU - Kallan, Michael J AU - Have, Thomas Ten AU - Lucki, Irwin AU - Katz, Ira AD - Department of Psychiatry, University of Pennsylvania, and MIRECC, Philadelphia Veterans Administration Medical Center, 19104, USA. PY - 2004 SP - 323 EP - 330 VL - 12 IS - 3 SN - 1064-7481, 1064-7481 KW - Serotonin Uptake Inhibitors KW - 0 KW - Paroxetine KW - 41VRH5220H KW - Sertraline KW - QUC7NX6WMB KW - Index Medicus KW - Double-Blind Method KW - Aged, 80 and over KW - Humans KW - Aged KW - Male KW - Female KW - Sertraline -- therapeutic use KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Health Status KW - Paroxetine -- therapeutic use KW - Mood Disorders -- epidemiology KW - Hypertension -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71903963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+geriatric+psychiatry+%3A+official+journal+of+the+American+Association+for+Geriatric+Psychiatry&rft.atitle=SSRIs+do+not+cause+affective+blunting+in+healthy+elderly+volunteers.&rft.au=Furlan%2C+Patricia+M%3BKallan%2C+Michael+J%3BHave%2C+Thomas+Ten%3BLucki%2C+Irwin%3BKatz%2C+Ira&rft.aulast=Furlan&rft.aufirst=Patricia&rft.date=2004-05-01&rft.volume=12&rft.issue=3&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+geriatric+psychiatry+%3A+official+journal+of+the+American+Association+for+Geriatric+Psychiatry&rft.issn=10647481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-24 N1 - Date created - 2004-05-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epoetin alfa treatment for acute anaemia during interferon plus ribavirin combination therapy for chronic hepatitis C. AN - 71896141; 15117320 AB - Infection with the hepatitis C virus (HCV) remains chronic in 75% of infected individuals, in whom it can cause liver inflammation and progressive fibrosis leading to cirrhosis in 20% of patients. A sustained viral response (SVR) to HCV therapy, i.e. undetectable plasma HCV RNA 6 months after the end of treatment, leads to permanent eradication of the virus in 98.3% of patients. The current treatment of choice is combination therapy with pegylated interferon alfa (PEG-IFN alfa), 2a or 2b, and ribavirin (RBV), which achieves an SVR in 54-56% of patients. In patients with HCV genotype 1, RBV doses of 1000-1200 mg/day are associated with a higher SVR than 800 mg/day (51 vs 40%). However, RBV also causes dose-dependent reversible haemolytic anaemia that, in combination with the myelosuppressive effects of PEG-IFN, results in a mean drop in haemoglobin (Hb) level of 3.7 g/dL within 4 weeks. Conventionally, this acute anaemia has been managed with RBV dose reductions. However, this may result in a decreased SVR rate. Alternatively, this anaemia can be managed with administration of epoetin alfa at 40 000 IU once weekly. In a randomized placebo-controlled trial, treatment with epoetin alfa has been shown to raise Hb levels and maintain RBV doses. Furthermore, the increase in Hb level was associated with improved quality of life. Anaemia in patients treated with interferon plus RBV combination therapy can be managed effectively and safely with once weekly epoetin alfa without sacrificing optimal dosing of RBV. JF - Journal of viral hepatitis AU - Bräu, N AD - Department of Medicine, Division of Infectious Diseases, Veterans Affairs Medical Center, Bronx, and Mount Sinai School of Medicine, New York, NY, USA. norbert.brau@med.va.gov Y1 - 2004/05// PY - 2004 DA - May 2004 SP - 191 EP - 197 VL - 11 IS - 3 SN - 1352-0504, 1352-0504 KW - Antiviral Agents KW - 0 KW - Hematinics KW - Interferon-alpha KW - Recombinant Proteins KW - Erythropoietin KW - 11096-26-7 KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2a KW - 47RRR83SK7 KW - Ribavirin KW - 49717AWG6K KW - Epoetin Alfa KW - 64FS3BFH5W KW - peginterferon alfa-2a KW - Q46947FE7K KW - Index Medicus KW - Hematinics -- administration & dosage KW - Drug Therapy, Combination KW - Antiviral Agents -- administration & dosage KW - Humans KW - Antiviral Agents -- adverse effects KW - Anemia, Hemolytic -- chemically induced KW - Interferon-alpha -- administration & dosage KW - Hepatitis C, Chronic -- drug therapy KW - Erythropoietin -- administration & dosage KW - Anemia, Hemolytic -- drug therapy KW - Hepatitis C, Chronic -- complications KW - Ribavirin -- administration & dosage KW - Polyethylene Glycols -- administration & dosage KW - Ribavirin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71896141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+viral+hepatitis&rft.atitle=Epoetin+alfa+treatment+for+acute+anaemia+during+interferon+plus+ribavirin+combination+therapy+for+chronic+hepatitis+C.&rft.au=Br%C3%A4u%2C+N&rft.aulast=Br%C3%A4u&rft.aufirst=N&rft.date=2004-05-01&rft.volume=11&rft.issue=3&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Journal+of+viral+hepatitis&rft.issn=13520504&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-07-02 N1 - Date created - 2004-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Suicidal ideation during interferon-alpha2b and ribavirin treatment of patients with chronic hepatitis C. AN - 71894915; 15121353 AB - Psychiatric and substance use disorders affect most patients with chronic hepatitis C and are the most common reasons for exclusion from antiviral therapies. Suicidal ideation (SI) is often cited as a reason to exclude patients from interferon-based treatment or to terminate antiviral treatment that is in progress. This study examines SI in hepatitis C patients untreated and treated with interferon-alpha2b, a medication commonly associated with depression. Fifty-five subjects with chronic hepatitis C were followed for 24 weeks with three measures of depression, each containing one item assessing SI. A total of 15/55 (27%) subjects reported SI while not on interferon therapy. Of the 42 patients treated with interferon, 18 (43%) endorsed SI at some point during antiviral treatment. However, 17/18 (94%) finished at least a 6-month course of interferon therapy. No subjects attempted suicide. Although SI in some form is common in hepatitis C patients, in most cases it is mild in nature. With adequate support most patients can successfully complete a full course of antiviral treatment. JF - General hospital psychiatry AU - Dieperink, Eric AU - Ho, Samuel B AU - Tetrick, Lori AU - Thuras, Paul AU - Dua, Kulwinder AU - Willenbring, Mark L AD - Department of Medicine, Veterans Affairs Medical Center, Minneapolis, MN, USA. eric.dieperink@med.va.gov PY - 2004 SP - 237 EP - 240 VL - 26 IS - 3 SN - 0163-8343, 0163-8343 KW - Anti-Retroviral Agents KW - 0 KW - Interferon-alpha KW - Recombinant Proteins KW - interferon alfa-2b KW - 43K1W2T1M6 KW - Sertraline KW - QUC7NX6WMB KW - Index Medicus KW - Depressive Disorder, Major -- diagnosis KW - Minnesota KW - Humans KW - Veterans -- psychology KW - Diagnosis, Dual (Psychiatry) KW - Substance-Related Disorders -- psychology KW - Health Services Accessibility KW - Depressive Disorder, Major -- drug therapy KW - Psychiatric Status Rating Scales KW - Sertraline -- therapeutic use KW - Adult KW - Follow-Up Studies KW - Middle Aged KW - Wisconsin KW - Female KW - Male KW - Interferon-alpha -- therapeutic use KW - Interferon-alpha -- adverse effects KW - Interferon-alpha -- contraindications KW - Hepatitis C, Chronic -- psychology KW - Hepatitis C, Chronic -- drug therapy KW - Anti-Retroviral Agents -- adverse effects KW - Suicide -- psychology KW - Anti-Retroviral Agents -- therapeutic use KW - Anti-Retroviral Agents -- contraindications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71894915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=General+hospital+psychiatry&rft.atitle=Suicidal+ideation+during+interferon-alpha2b+and+ribavirin+treatment+of+patients+with+chronic+hepatitis+C.&rft.au=Dieperink%2C+Eric%3BHo%2C+Samuel+B%3BTetrick%2C+Lori%3BThuras%2C+Paul%3BDua%2C+Kulwinder%3BWillenbring%2C+Mark+L&rft.aulast=Dieperink&rft.aufirst=Eric&rft.date=2004-05-01&rft.volume=26&rft.issue=3&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=General+hospital+psychiatry&rft.issn=01638343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-24 N1 - Date created - 2004-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thrombocytopenia due to acute venous thromboembolism and its role in expanding the differential diagnosis of heparin-induced thrombocytopenia. AN - 71884608; 15114601 AB - Thrombocytopenia is an uncommon but serious consequence of heparin administration. Occasionally patients with massive acute venous thromboembolism (VTE) will develop thrombocytopenia. As heparin or some thrombin inhibitor is strongly indicated in acute VTE, it is important to distinguish this event from heparin-induced thrombocytopenia (HIT). Four patients are presented who developed thrombocytopenia so early in their course of VTE and/or therapy with heparin that HIT was considered unlikely. The mean nadir platelet count for these four patients was 60,000/microl occurring at a mean time of 18 hr after the initiation of heparin therapy. Because of strong indications to continue heparin for their acute VTE in the face of a very low likelihood that they did have HIT, heparin was continued with excellent results and resolution of the thrombocytopenia. The literature of this subject is reviewed. Thrombocytopenia following VTE is actually rather common, but it is usually milder than in these four cases. In some cases such as these four, the thrombocytopenia can be sudden and rather severe causing diagnostic confusion with HIT. Copyright 2004 Wiley-Liss, Inc. JF - American journal of hematology AU - Kitchens, Craig S AD - Division of Hematology, Department of Medicine, University of Florida, Gainesville, Florida, USA. craig.kitchens@med.va.gov Y1 - 2004/05// PY - 2004 DA - May 2004 SP - 69 EP - 73 VL - 76 IS - 1 SN - 0361-8609, 0361-8609 KW - Heparin KW - 9005-49-6 KW - Index Medicus KW - Acute Disease KW - Diagnosis, Differential KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Male KW - Female KW - Thrombocytopenia -- etiology KW - Venous Thrombosis -- complications KW - Thromboembolism -- complications KW - Thrombocytopenia -- diagnosis KW - Thrombocytopenia -- chemically induced KW - Heparin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71884608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+hematology&rft.atitle=Thrombocytopenia+due+to+acute+venous+thromboembolism+and+its+role+in+expanding+the+differential+diagnosis+of+heparin-induced+thrombocytopenia.&rft.au=Kitchens%2C+Craig+S&rft.aulast=Kitchens&rft.aufirst=Craig&rft.date=2004-05-01&rft.volume=76&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=American+journal+of+hematology&rft.issn=03618609&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-06-03 N1 - Date created - 2004-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - MUC1 and MUC2 in pancreatic neoplasia. AN - 71875939; 15113850 AB - MUCs are glycoproteins with various roles in homeostasis and carcinogenesis. Among other actions, MUC1 may inhibit cell-cell and cell-stroma interactions and function as a signal transducer, participating in cancer progression. In contrast, MUC2 is normally found only in goblet cells, where it contributes to the protective barrier function of these cells. Recently, a tumour suppressor role has been demonstrated for MUC2, and both MUC1 and MUC2 appear to have important roles in pancreatic neoplasia. MUC1 appears to be a marker of aggressive phenotype and may facilitate the vascular spread of carcinoma cells. In contrast, MUC2 is rarely detectable in aggressive pancreatic tumours, but is commonly expressed in intraductal papillary mucinous neoplasms (IPMNs), which are rare, indolent tumours, in intestinal IPMNs, and in indolent colloid carcinomas. MUC2 appears to be not only a marker of this indolent pathway, but also partly responsible for its less aggressive nature. Thus, in pancreatic neoplasia, MUC1 and MUC2 have potential diagnostic and prognostic value as markers of aggressive and indolent phenotypes, respectively, and have potential as therapeutic targets. JF - Journal of clinical pathology AU - Levi, E AU - Klimstra, D S AU - Andea, A AU - Basturk, O AU - Adsay, N V AD - John Dingell Veterans Administration Medical Center, 4646 John Road, Detroit, MI 48201, USA. Y1 - 2004/05// PY - 2004 DA - May 2004 SP - 456 EP - 462 VL - 57 IS - 5 SN - 0021-9746, 0021-9746 KW - MUC1 tandem repeat peptide KW - 0 KW - MUC2 protein, human KW - Mucin-1 KW - Mucin-2 KW - Mucins KW - Neoplasm Proteins KW - Peptide Fragments KW - Abridged Index Medicus KW - Index Medicus KW - Neoplasm Invasiveness KW - Humans KW - Cell Transformation, Neoplastic KW - Pancreatic Neoplasms -- pathology KW - Mucin-1 -- physiology KW - Pancreatic Neoplasms -- chemistry KW - Neoplasm Proteins -- physiology KW - Mucins -- analysis KW - Mucins -- physiology KW - Peptide Fragments -- analysis KW - Mucin-1 -- analysis KW - Neoplasm Proteins -- analysis KW - Peptide Fragments -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71875939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+pathology&rft.atitle=MUC1+and+MUC2+in+pancreatic+neoplasia.&rft.au=Levi%2C+E%3BKlimstra%2C+D+S%3BAndea%2C+A%3BBasturk%2C+O%3BAdsay%2C+N+V&rft.aulast=Levi&rft.aufirst=E&rft.date=2004-05-01&rft.volume=57&rft.issue=5&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+pathology&rft.issn=00219746&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-25 N1 - Date created - 2004-04-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mod Pathol. 2002 Oct;15(10):1087-95 [12379756] J Gastrointest Surg. 2002 Sep-Oct;6(5):656-9 [12399051] J Mammary Gland Biol Neoplasia. 2002 Apr;7(2):209-21 [12463741] Adv Surg. 2002;36:15-38 [12465545] J Biol Chem. 2002 Dec 13;277(50):48270-5 [12374798] J Pathol. 2003 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AN - 71804121; 15069302 AB - Non-hazardous waste management facilities, which are not authorized to receive licensable radioactive material (RAM), periodically find contaminated waste in shipments from local healthcare facilities. As a consequence, many healthcare facilities are cited each year for losing control and/or improperly disposing of RAM at unauthorized disposal sites. Healthcare radiation safety professionals must ensure that effective measures are in place at their facilities to prevent RAM from inadvertently being included with non-radioactive waste shipments. The objective of this article is to assist in developing and implementing procedures to properly monitor and dispose of waste containing RAM. This article discusses, among other topics, the installation of portal monitors containing both visual and audible alarms to screen medical waste, instruction to individuals handling medical waste and emergency response procedures. JF - Health physics AU - Michel, René AU - Zorn, Michael J AD - VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA. rene.michel@med.va.gov Y1 - 2004/05// PY - 2004 DA - May 2004 SP - S116 EP - S119 VL - 86 IS - 5 Suppl SN - 0017-9078, 0017-9078 KW - Radioactive Waste KW - 0 KW - Index Medicus KW - United States KW - Risk Management -- methods KW - Risk Management -- organization & administration KW - Risk Management -- standards KW - Radiation Protection -- methods KW - Safety Management -- standards KW - Safety Management -- methods KW - Waste Management -- methods KW - Radioactive Waste -- prevention & control KW - Safety Management -- organization & administration KW - Health Facilities -- standards KW - Waste Management -- standards KW - Radiation Protection -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71804121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Preventing+improper+disposal+of+healthcare+facility+waste+containing+RAM.&rft.au=Michel%2C+Ren%C3%A9%3BZorn%2C+Michael+J&rft.aulast=Michel&rft.aufirst=Ren%C3%A9&rft.date=2004-05-01&rft.volume=86&rft.issue=5+Suppl&rft.spage=S116&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-21 N1 - Date created - 2004-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sensitization to the psychosis-inducing effects of cocaine compared with measures of cocaine craving and cue reactivity. AN - 66875641; 15370950 AB - A previous study has suggested that sensitization to the psychosis-inducing effects of cocaine may be a marker of vulnerability to relapse in cocaine addiction. In this report, cocaine-dependent subjects participating in a study on naturally occurring and cue-induced cocaine craving were interviewed about prior experience of cocaine-induced psychosis and the degree to which this effect had become more frequent or severe or had occurred at lower cumulative doses. Sensitization to cocaine-induced psychosis was negatively correlated with baseline measures of drug dependence severity and indices of cocaine craving over the preceding 24 hours but not with measures of cocaine cue reactivity. JF - The American journal on addictions AU - Reid, Malcolm S AU - Ciplet, Debra AU - O'Leary, Siobhan AU - Branchey, Marc AU - Buydens-Branchey, Laure AU - Angrist, Burt AD - Department of Psychiatry, New York University School of Medicine, New York, NY, USA. malcolm.reid@med.va.gov PY - 2004 SP - 305 EP - 315 VL - 13 IS - 3 SN - 1055-0496, 1055-0496 KW - Dopamine Uptake Inhibitors KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Humans KW - Adult KW - Drug Resistance KW - Middle Aged KW - Recurrence KW - Male KW - Female KW - Cocaine-Related Disorders -- physiopathology KW - Psychotic Disorders -- etiology KW - Cocaine -- pharmacology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66875641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Sensitization+to+the+psychosis-inducing+effects+of+cocaine+compared+with+measures+of+cocaine+craving+and+cue+reactivity.&rft.au=Reid%2C+Malcolm+S%3BCiplet%2C+Debra%3BO%27Leary%2C+Siobhan%3BBranchey%2C+Marc%3BBuydens-Branchey%2C+Laure%3BAngrist%2C+Burt&rft.aulast=Reid&rft.aufirst=Malcolm&rft.date=2004-05-01&rft.volume=13&rft.issue=3&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-10-19 N1 - Date created - 2004-09-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Frequency of simvastatin prescriptions with potentially interacting medications in a Veterans Affairs health care system. AN - 66669609; 15228374 AB - The primary objective of this review is to quantify the proportion of patients on simvastatin, an HMG-CoA reductase inhibitor (commonly known as statin), who received concurrent prescriptions for potentially interacting chronicuse medications. The secondary objective is to determine the frequency with which simvastatin was prescribed above its recommended dose when administered concomitantly with known interacting medications. A retrospective review of computerized outpatient pharmacy records from a Veterans Affairs Medical Center and its associated ambulatory clinics was performed in September 2002. A total of 12,240 patients had an active prescription for a statin. The majority of patients (95%, N = 11,677) were on simvastatin therapy, and 1,231 (10.5%) of the patients on simvastatin were prescribed at least 1 potentially interacting medication. More than one half (57.8%) of simvastatin doses were above the maximum recommended daily dose when prescribed with potentially interacting medications. This analysis supports the need for vigilance in reviewing the dose of simvastatin in patients receiving interacting medications. Health care systems should consider strategies to educate health care professionals on prevention of drug interactions and adverse patient outcomes. JF - Journal of managed care pharmacy : JMCP AU - Petropoulos, Jerilyn B AU - Bello-Quintero, Cristina E AD - Medical Information, VA Medical Center, 1201 NW 16th St. (119), Miami, FL 33125, USA. Jerilyn.Petropoulos@med.va.gov PY - 2004 SP - 239 EP - 243 VL - 10 IS - 3 SN - 1083-4087, 1083-4087 KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - 0 KW - Simvastatin KW - AGG2FN16EV KW - Index Medicus KW - United States KW - Drug Interactions KW - Aged, 80 and over KW - Humans KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Florida KW - Male KW - Female KW - Simvastatin -- therapeutic use KW - Delivery of Health Care -- organization & administration KW - United States Department of Veterans Affairs KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- therapeutic use KW - Drug Utilization Review UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66669609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+managed+care+pharmacy+%3A+JMCP&rft.atitle=Frequency+of+simvastatin+prescriptions+with+potentially+interacting+medications+in+a+Veterans+Affairs+health+care+system.&rft.au=Petropoulos%2C+Jerilyn+B%3BBello-Quintero%2C+Cristina+E&rft.aulast=Petropoulos&rft.aufirst=Jerilyn&rft.date=2004-05-01&rft.volume=10&rft.issue=3&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Journal+of+managed+care+pharmacy+%3A+JMCP&rft.issn=10834087&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-19 N1 - Date created - 2004-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exploring the effectiveness of tazobactam against ceftazidime resistant Escherichia coli: insights from the comparison between susceptibility testing and beta -lactamase inhibition AN - 18008348; 5953754 AB - Thirteen clinical isolates of Escherichia coli resistant to ceftazidime that possessed an AmpC and other ( beta -lactamases were identified. The effectiveness of different formulations of piperacillin/tazobactam to other beta -lactams was compared. Antibiotic susceptibility testing, polymerase chain reaction, amplification of blaTEM, blaSHV and blaAmpC, and enzyme-linked immunosorbent assays to identify AmpC beta -lactamases were performed. Hydrolysis rates were obtained and residual enzymatic activity was determined. Cefepime and ertapenem were more active than piperacillin/tazobactam. In contrast, increasing the relative proportion of tazobactam improved susceptibility testing. Twenty micromolar tazobactam inhibited total beta -lactamase activity (as measured by nitrocefin hydrolysis rates) by greater than 75% against all isolates tested: in 11 of 13 E. coli isolates, total beta -lactamase activity was inhibited by 90%. The observed differences between MIC determinations and susceptibility to enzymatic inactivation by tazobactam against E. coli containing AmpC and other beta -lactamases may be due to the final tazobactam concentration achieved in the periplasmic space. Factors determining this are critical considerations in assessing beta -lactamase inhibitor potency. JF - FEMS Microbiology Letters AU - Bethel, C R AU - Hujer, AM AU - Helfand AU - Bonomo, R A AD - Infectious Diseases Section, Geriatrics and Extended Care, Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA, robert.bonomo@med.va.gov Y1 - 2004/05/01/ PY - 2004 DA - 2004 May 01 SP - 99 EP - 103 VL - 234 IS - 1 SN - 0378-1097, 0378-1097 KW - blaAmpC gene KW - Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Enzyme-linked immunosorbent assay KW - ertapenem KW - Tazobactam KW - Minimum inhibitory concentration KW - Ceftazidime KW - Cefepime KW - Antibiotic sensitivity testing KW - Escherichia coli KW - Polymerase chain reaction KW - Piperacillin KW - ^b-Lactamase KW - J 02785:Beta-lactam antibiotics KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18008348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEMS+Microbiology+Letters&rft.atitle=Exploring+the+effectiveness+of+tazobactam+against+ceftazidime+resistant+Escherichia+coli%3A+insights+from+the+comparison+between+susceptibility+testing+and+beta+-lactamase+inhibition&rft.au=Bethel%2C+C+R%3BHujer%2C+AM%3BHelfand%3BBonomo%2C+R+A&rft.aulast=Bethel&rft.aufirst=C&rft.date=2004-05-01&rft.volume=234&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=FEMS+Microbiology+Letters&rft.issn=03781097&rft_id=info:doi/10.1016%2Fj.femsle.2004.03.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Clinical isolates; Tazobactam; Ceftazidime; ^b-Lactamase; Piperacillin; Antibiotic sensitivity testing; Polymerase chain reaction; Enzyme-linked immunosorbent assay; ertapenem; Cefepime; Minimum inhibitory concentration DO - http://dx.doi.org/10.1016/j.femsle.2004.03.025 ER - TY - JOUR T1 - Intranasal Immunization with Multivalent Group A Streptococcal Vaccines Protects Mice against Intranasal Challenge Infections AN - 17939675; 5887620 AB - We have previously shown that a hexavalent group A streptococcal M protein- based vaccine evoked bactericidal antibodies after intramuscular injection. In the present study, we show that the hexavalent vaccine formulated with several different mucosal adjuvants and delivered intranasally induced serum and salivary antibodies that protected mice from intranasal challenge infections with virulent group A streptococci. The hexavalent vaccine was formulated with liposomes with or without monophosphorylated lipid A (MPL), cholera toxin B subunit with or without holotoxin, or proteosomes from Neisseria meningitidis outer membrane proteins complexed with lipopolysaccharide from Shigella flexneri. Intranasal immunization with the hexavalent vaccine mixed with these adjuvants resulted in significant levels of antibodies in serum 2 weeks after the final dose. Mean serum antibody titers were equivalent in all groups of mice except those that were immunized with hexavalent protein plus liposomes without MPL, which were significantly lower. Salivary antibodies were also detected in mice that received the vaccine formulated with the four strongest adjuvants. T-cell proliferative assays and cytokine assays using lymphocytes from cervical lymph nodes and spleens from mice immunized with the hexavalent vaccine formulated with proteosomes indicated the presence of hexavalent protein-specific T cells and a Th1-weighted mixed Th1-Th2 cytokine profile. Intranasal immunization with adjuvanted formulations of the hexavalent vaccine resulted in significant levels of protection (80 to 100%) following intranasal challenge infections with type 24 group A streptococci. Our results indicate that intranasal delivery of adjuvanted multivalent M protein vaccines induces protective antibody responses and may provide an alternative to parenteral vaccine formulations. JF - Infection and Immunity AU - Hall, MA AU - Stroop, S D AU - Hu, M C AU - Walls, MA AU - Reddish, MA AU - Burt, D S AU - Lowell, G H AU - Dale, J B AD - VA Medical Center (11A), 1030 Jefferson Ave., Memphis, TN 38104, james.dale@med.va.gov Y1 - 2004/05// PY - 2004 DA - May 2004 SP - 2507 EP - 2512 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 72 IS - 5 SN - 0019-9567, 0019-9567 KW - mice KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - cholera toxin B subunit KW - Lipid A KW - Vaccines KW - Neisseria meningitidis KW - Streptococcus pyogenes KW - J 02834:Vaccination and immunization KW - F 06807:Active immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17939675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Intranasal+Immunization+with+Multivalent+Group+A+Streptococcal+Vaccines+Protects+Mice+against+Intranasal+Challenge+Infections&rft.au=Hall%2C+MA%3BStroop%2C+S+D%3BHu%2C+M+C%3BWalls%2C+MA%3BReddish%2C+MA%3BBurt%2C+D+S%3BLowell%2C+G+H%3BDale%2C+J+B&rft.aulast=Hall&rft.aufirst=MA&rft.date=2004-05-01&rft.volume=72&rft.issue=5&rft.spage=2507&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.72.5.2507-2512.2004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pyogenes; Neisseria meningitidis; Lipid A; Vaccines; cholera toxin B subunit DO - http://dx.doi.org/10.1128/IAI.72.5.2507-2512.2004 ER - TY - JOUR T1 - Identification of hibernating myocardium by acoustic microscopy AN - 17569011; 5924077 AB - Hibernating myocardium is viable myocardium that recovers after revascularization. The observation of loss of contractile proteins (myofibrils) and accumulation of glycogen in hibernating cardiomyocytes provide the basis for diagnosing hibernating myocardium. In this pilot study, acoustic microscopy was used to identify the cellular structure of normal vs. hibernating myocardium. Sections cut at 5- mu m of archival paraffin blocks on glass slides were used for this study. Acoustic microscopy of normal cardiomyocytes showed intracellular linear echoes suggestive of myofibrils, and cardiomyocytes of hibernating myocardium revealed absence of myofibrils and dense intracellular echoes that corresponded to glycogen accumulation on optical microscopy. This modality of visualization allows a definitive diagnosis of hibernating myocardium. JF - Ultrasound in Medicine & Biology AU - Ng, D AU - Sathish, S AU - Khan, A AU - Chandrasoma, P AU - Wijns, W AU - Chandraratna, PAN AD - Division of Cardiology, LAC+USC Medical Center, University of Southern California School of Medicine, Los Angeles, CA, USA, premindra.chandraratna@med.va.gov Y1 - 2004/05// PY - 2004 DA - May 2004 SP - 693 EP - 696 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 30 IS - 5 SN - 0301-5629, 0301-5629 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Paraffin KW - Acoustics KW - Microscopy KW - cardiomyocytes KW - Contractility KW - Ultrasound KW - Glycogen KW - Myofibrils KW - Myocardium KW - W4 150:Medical Imaging KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17569011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Medicine+%26+Biology&rft.atitle=Identification+of+hibernating+myocardium+by+acoustic+microscopy&rft.au=Ng%2C+D%3BSathish%2C+S%3BKhan%2C+A%3BChandrasoma%2C+P%3BWijns%2C+W%3BChandraratna%2C+PAN&rft.aulast=Ng&rft.aufirst=D&rft.date=2004-05-01&rft.volume=30&rft.issue=5&rft.spage=693&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Medicine+%26+Biology&rft.issn=03015629&rft_id=info:doi/10.1016%2Fj.ultrasmedbio.2004.03.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Myocardium; Microscopy; cardiomyocytes; Myofibrils; Acoustics; Glycogen; Paraffin; Ultrasound; Contractility DO - http://dx.doi.org/10.1016/j.ultrasmedbio.2004.03.012 ER - TY - JOUR T1 - Endocarditis Caused by Staphylococcus aureus with Reduced Susceptibility to Vancomycin AN - 17751197; 5908617 AB - Clinical management of infective endocarditis (IE) is expected to become more difficult with the emergence of Staphylococcus aureus with reduced susceptibility to vancomycin (SARV) in the United States and worldwide. We report the strain characterization and treatment of a patient with SARV IE. JF - Clinical Infectious Diseases AU - Woods, C W AU - Cheng, A C AU - Fowler, VG Jr AU - Moorefield, M AU - Frederick, J AU - Sakoulas, G AU - Meka, V G AU - Tenover, F C AU - Zwadyk, P AU - Wilson, KH AD - Durham Veterans Administration Medical Center and Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA Y1 - 2004/04/15/ PY - 2004 DA - 2004 Apr 15 SP - 1188 EP - 1191 VL - 38 IS - 8 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology KW - Vancomycin KW - Staphylococcus aureus KW - Endocarditis KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17751197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Endocarditis+Caused+by+Staphylococcus+aureus+with+Reduced+Susceptibility+to+Vancomycin&rft.au=Woods%2C+C+W%3BCheng%2C+A+C%3BFowler%2C+VG+Jr%3BMoorefield%2C+M%3BFrederick%2C+J%3BSakoulas%2C+G%3BMeka%2C+V+G%3BTenover%2C+F+C%3BZwadyk%2C+P%3BWilson%2C+KH&rft.aulast=Woods&rft.aufirst=C&rft.date=2004-04-15&rft.volume=38&rft.issue=8&rft.spage=1188&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Staphylococcus aureus; Endocarditis; Vancomycin ER - TY - JOUR T1 - Stimulation of beta-amyloid precursor protein alpha-processing by phorbol ester involves calcium and calpain activation. AN - 71722250; 15020222 AB - Normal processing of Alzheimer's beta-amyloid precursor protein (APP) is markedly stimulated by phorbol esters, but the underlying mechanisms have yet to be fully understood. In this study, we observed that: (a) Phorbol 12,13-dibutyrate (PDBu)-stimulated APP secretion in cultured SH-SY5Y neuroblastoma and fibroblast cells was blocked by EGTA and calpain inhibitors in a concentration-dependent manner, but not by other protease inhibitors. (b) Secretion of fibronectin, another secretory protein tested for comparison, was enhanced by PDBu, but insensitive to calpain inhibitors. (c) PDBu stimulated intracellular calpain activity as measured by the hydrolysis of a fluorogenic calpain substrate. (d) PDBu also induced rapid proteolysis of two endogenous substrates of calpains, i.e., tau and microtubule-associated protein-2 (MAP-2) and the proteolysis was blocked by EGTA and calpain inhibitors. Taken together, these results suggest that stimulation of APP alpha-processing by PDBu is through a mechanism that involves the activation of Ca(2+) and, most notably, calpain. The implications of the findings are discussed in relation to the regulatory mechanism of APP alpha-processing. JF - Biochemical and biophysical research communications AU - Chen, Ming AU - Fernandez, Hugo L AD - Neurobiology of Aging Research Laboratory, Medical Research Service, Bay Pines VA Medical Center, FL 33744, USA. ming.chen@med.va.gov Y1 - 2004/04/02/ PY - 2004 DA - 2004 Apr 02 SP - 332 EP - 340 VL - 316 IS - 2 SN - 0006-291X, 0006-291X KW - Amyloid beta-Protein Precursor KW - 0 KW - Chelating Agents KW - Enzyme Inhibitors KW - Fibronectins KW - Microtubule-Associated Proteins KW - Peptide Fragments KW - alpha-sAPP protein, human KW - tau Proteins KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - Egtazic Acid KW - 526U7A2651 KW - Calpain KW - EC 3.4.22.- KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Chelating Agents -- pharmacology KW - tau Proteins -- metabolism KW - Microtubule-Associated Proteins -- metabolism KW - Enzyme Activation KW - Cells, Cultured KW - Humans KW - Fibronectins -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Egtazic Acid -- pharmacology KW - Peptide Fragments -- metabolism KW - Calpain -- antagonists & inhibitors KW - Calcium -- physiology KW - Amyloid beta-Protein Precursor -- metabolism KW - Calpain -- metabolism KW - Phorbol 12,13-Dibutyrate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71722250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Stimulation+of+beta-amyloid+precursor+protein+alpha-processing+by+phorbol+ester+involves+calcium+and+calpain+activation.&rft.au=Chen%2C+Ming%3BFernandez%2C+Hugo+L&rft.aulast=Chen&rft.aufirst=Ming&rft.date=2004-04-02&rft.volume=316&rft.issue=2&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-27 N1 - Date created - 2004-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Accuracy of Formal Tests for Diagnosing Mild Aphasia: An Application of Evidence-Based Medicine AN - 85577838; 200409566 AB - Normal elderly & mildly aphasic individuals may exhibit similar impairments in language comprehension & expression. Accurate differential diagnosis is essential for providing a prognosis, focusing treatment, & justifying reimbursement for services. We employed the principles of evidence-based medicine to examine the accuracy of two general language tests (Porch Index of Communicative Ability & Western Aphasia Battery) & two functional communication tests (Communication Activities of Daily Living & American Speech-Language-Hearing Association's Functional Assessment of Communication Skills for Adults) for diagnosing mild aphasia, beyond individual clinical expertise. The test performance of 10 mildly aphasic patients was compared with that of 10 non-brain-injured (NBI) adults. An operational definition of aphasia was applied as a reference standard for correct diagnosis. Pre-test & post-test diagnostic probabilities were compared, using the likelihood ratio as an index of accuracy. In our sample, we obtained positive likelihood ratios ranged from 3.00 to 6000.60, & the post-test probability of a correct positive diagnosis ranged from 91% to 100%. However, the pre-test probability of a correct positive diagnosis was already high (70-100%), because information necessary to diagnose correctly was available to the clinician prior to formal test administration. Thus, an overall score derived from subsequent administration of a formal test added, at best, moderate improvement over individual clinical expertise. The tests may prove more important for clinicians uncertain of a patient's diagnosis or for diagnosing "borderline" patients whose symptoms are unclear. For pre-test probabilities between 40% & 60%, administration of one of the formal tests we examined may increase or decrease diagnostic probability by as many as 60 percentage points. Results indicate that overall scores derived from these tests are accurate but may or may not be important in confirming the presence or absence of mild aphasia, depending on the pre-test probability of a positive diagnosis. Suggestions for testing the validity of our results within a wider spectrum of patients are provided. 9 Tables, 3 Appendixes, 32 References. Adapted from the source document JF - Aphasiology AU - Ross, Katherine B AU - Wertz, Robert T AD - Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ katherine.ross3@med.va.gov Y1 - 2004/04// PY - 2004 DA - April 2004 SP - 337 EP - 355 VL - 18 IS - 4 SN - 0268-7038, 0268-7038 KW - Elderly (21350) KW - Language Tests (44250) KW - Aphasia (03400) KW - Speech Pathology (82650) KW - Language Pathology (43250) KW - Test Validity and Reliability (88800) KW - article KW - 6414: language-pathological and normal; aphasia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85577838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Accuracy+of+Formal+Tests+for+Diagnosing+Mild+Aphasia%3A+An+Application+of+Evidence-Based+Medicine&rft.au=Ross%2C+Katherine+B%3BWertz%2C+Robert+T&rft.aulast=Ross&rft.aufirst=Katherine&rft.date=2004-04-01&rft.volume=18&rft.issue=4&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2004-08-01 N1 - Last updated - 2016-09-27 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Elderly (21350); Language Tests (44250); Speech Pathology (82650); Language Pathology (43250); Test Validity and Reliability (88800) ER - TY - JOUR T1 - The performance-perceptual test and its relationship to unaided reported handicap. AN - 85382394; pmid-15064656 AB - Measurement of hearing aid outcomes is necessary for demonstration of treatment efficacy, third-party payment, and cost-benefit analysis. Outcomes are usually measured with hearing-related questionnaires and/or tests of speech recognition. However, results from these two types of test often conflict. In this paper, we provide data from a new test measure, known as the Performance-Perceptual Test (PPT), in which subjective and performance aspects of hearing in noise are measured using the same test materials and procedures. A Performance Speech Reception Threshold (SRTN) and a Perceptual SRTN are measured using the Hearing In Noise Test materials and adaptive procedure. A third variable, the discrepancy between these two SRTNs, is also computed. It measures the accuracy with which subjects assess their own hearing ability and is referred to as the Performance-Perceptual Discrepancy (PPDIS).One hundred seven subjects between 24 and 83 yr of age took part. Thirty-three subjects had normal hearing, while the remaining seventy-four had symmetrical sensorineural hearing loss. Of the subjects with impaired hearing, 24 wore hearing aids and 50 did not. All subjects underwent routine audiological examination and completed the PPT and the Hearing Handicap Inventory for the Elderly/Adults on two occasions, between 1 and 2 wk apart. The PPT was conducted for unaided listening with the masker level set to 50, 65, and 80 dB SPL.PPT data show that the subjects with normal hearing have significantly better Performance and Perceptual SRTNs at each test level than the subjects with impaired hearing but that PPDIS values do not differ between the groups. Test-retest reliability for the PPT is excellent (r-values > 0.93 for all conditions). Stepwise multiple regression analysis showed that the Performance SRTN, the PPDIS, and age explain 40% of the variance in reported handicap (Hearing Handicap Inventory for the Elderly/Adults scores). More specifically, poorer performance, underestimation of hearing ability and younger age result in greater reported handicap, and vice versa.Reported handicap consists of a performance component and a (mis)perception component, as measured by the Performance SRTN and the PPDIS respectively. The PPT should thus prove to be a valuable tool for better understanding why some individuals complain of hearing difficulties but have only a mild hearing loss or conversely report few difficulties in the presence of substantial impairment. The measure would thus seem to provide both an explanation and a counseling tool for patients for whom there is a mismatch between reported and measured hearing difficulties. JF - Ear and hearing AU - Saunders, Gabrielle H AU - Forsline, Anna AU - Fausti, Stephen A AD - The National Center for Rehabilitative Auditory Research, Portland, Oregon 97207, USA. Gabrielle.Saunders@med.va.gov Y1 - 2004/04// PY - 2004 DA - Apr 2004 SP - 117 EP - 126 VL - 25 IS - 2 SN - 0196-0202, 0196-0202 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Aged, 80 and over KW - Audiometry, Pure-Tone KW - Audiometry, Speech KW - Case-Control Studies KW - Female KW - *Hearing Aids KW - *Hearing Loss: diagnosis KW - Hearing Loss: therapy KW - *Hearing Tests: methods KW - Humans KW - Male KW - Middle Aged KW - Noise: adverse effects KW - Perceptual Masking KW - Questionnaires KW - *Speech Perception KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85382394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear+and+hearing&rft.atitle=The+performance-perceptual+test+and+its+relationship+to+unaided+reported+handicap.&rft.au=Saunders%2C+Gabrielle+H%3BForsline%2C+Anna%3BFausti%2C+Stephen+A&rft.aulast=Saunders&rft.aufirst=Gabrielle&rft.date=2004-04-01&rft.volume=25&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Ear+and+hearing&rft.issn=01960202&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Self-hypnosis relapse prevention training with chronic drug/alcohol users: effects on self-esteem, affect, and relapse. AN - 72014339; 15190730 AB - This study evaluated the effectiveness of a self-hypnosis protocol with chronic drug and alcohol patients in increasing self-esteem, improving affect, and preventing relapse against a control, a transtheoretical cognitive-behavioral (TCB), and a stress management (attention-placebo) group. Participants were 261 veterans admitted to Substance Abuse Residential Rehabilitation Treatment Programs (SARRTPs). Participants were assessed pre- and postintervention, and at 7-week follow-up. Relapse rates did not significantly differ across the 4 groups at follow-up; 87% of those contacted reported abstinence. At follow-up, the participants in the 3 treatment conditions were asked how often they practiced the intervention materials provided them. Practicing and minimal-practicing participants were compared against the control group for each of the 3 interventions via MANOVAs/ANOVAs. Results revealed a significant Time by Groups interaction for the hypnosis intervention, with individuals who played the self-hypnosis audiotapes "at least 3 to 5 times a week" at 7-week follow-up reporting the highest levels of self-esteem and serenity, and the least anger/impulsivity, in comparison to the minimal-practice and control groups. No significant effects were found for the transtheoretical or stress management interventions. Regression analyses predicted almost two-thirds of the variance of who relapsed and who did not in the hypnosis intervention group. Hypnotic susceptibility predicted who practiced the self-hypnosis audiotapes. The results suggest that hypnosis can be a useful adjunct in helping chronic substance abuse individuals with their reported self-esteem, serenity, and anger/impulsivity. JF - The American journal of clinical hypnosis AU - Pekala, Ronald J AU - Maurer, Ronald AU - Kumar, V K AU - Elliott, Nancy C AU - Masten, Ellsworth AU - Moon, Edward AU - Salinger, Margaret AD - Biofeedback Clinic (116B), Coatesville VA Medical Center, Coatesville, PA 19320-2096, USA. Ronald.Pekala@med.va.gov Y1 - 2004/04// PY - 2004 DA - April 2004 SP - 281 EP - 297 VL - 46 IS - 4 SN - 0002-9157, 0002-9157 KW - Index Medicus KW - Humans KW - Alcoholism -- therapy KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Chronic Disease KW - Secondary Prevention KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - Self Concept KW - Self Efficacy KW - Affect KW - Hypnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72014339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+hypnosis&rft.atitle=Self-hypnosis+relapse+prevention+training+with+chronic+drug%2Falcohol+users%3A+effects+on+self-esteem%2C+affect%2C+and+relapse.&rft.au=Pekala%2C+Ronald+J%3BMaurer%2C+Ronald%3BKumar%2C+V+K%3BElliott%2C+Nancy+C%3BMasten%2C+Ellsworth%3BMoon%2C+Edward%3BSalinger%2C+Margaret&rft.aulast=Pekala&rft.aufirst=Ronald&rft.date=2004-04-01&rft.volume=46&rft.issue=4&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+hypnosis&rft.issn=00029157&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-07-27 N1 - Date created - 2004-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Incorporating clinical monitoring into electronic orders for antipsychotics. AN - 71808400; 15067165 JF - Psychiatric services (Washington, D.C.) AU - Roche-Desilets, Jennifer AU - Fuller, Matthew A AU - Konicki, P Eric AD - Psychiatry Service of Louis Stokes Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA. jennifer.roche@med.va.gov Y1 - 2004/04// PY - 2004 DA - April 2004 SP - 455 VL - 55 IS - 4 SN - 1075-2730, 1075-2730 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Humans KW - Diabetes Mellitus -- chemically induced KW - Diabetic Ketoacidosis -- epidemiology KW - Drug Monitoring -- methods KW - Antipsychotic Agents -- therapeutic use KW - Automatic Data Processing KW - Antipsychotic Agents -- adverse effects KW - Psychotic Disorders -- epidemiology KW - Psychotic Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71808400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Incorporating+clinical+monitoring+into+electronic+orders+for+antipsychotics.&rft.au=Roche-Desilets%2C+Jennifer%3BFuller%2C+Matthew+A%3BKonicki%2C+P+Eric&rft.aulast=Roche-Desilets&rft.aufirst=Jennifer&rft.date=2004-04-01&rft.volume=55&rft.issue=4&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-06 N1 - Date created - 2004-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical problem-solving. Red snapper or crab? AN - 71804508; 15070795 JF - The New England journal of medicine AU - Cornia, Paul B AU - Lipsky, Benjamin A AU - Dhaliwal, Gurpreet AU - Saint, Sanjay AD - Primary and Specialty Medical Care Service, Veterans Affairs Puget Sound Health Care System, Seattle 98108-1597, USA. paul.cornia@med.va.gov Y1 - 2004/04/01/ PY - 2004 DA - 2004 Apr 01 SP - 1443 EP - 1448 VL - 350 IS - 14 KW - Asbestos KW - 1332-21-4 KW - Abridged Index Medicus KW - Index Medicus KW - Occupational Diseases -- diagnosis KW - Ascites -- etiology KW - Diagnosis, Differential KW - Lung -- diagnostic imaging KW - Humans KW - Tomography, X-Ray Computed KW - Tuberculosis, Pulmonary -- diagnosis KW - Aged KW - Pleural Effusion -- etiology KW - Thrombosis -- diagnostic imaging KW - Military Personnel KW - Thrombosis -- complications KW - Asbestos -- adverse effects KW - Jugular Veins -- diagnostic imaging KW - Dyspnea -- etiology KW - Tuberculin Test KW - Male KW - Paracentesis KW - Pleural Effusion -- microbiology KW - Mesothelioma -- diagnosis KW - Peritoneal Neoplasms -- complications KW - Mesothelioma -- complications KW - Omentum -- diagnostic imaging KW - Omentum -- pathology KW - Peritoneal Neoplasms -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71804508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Clinical+problem-solving.+Red+snapper+or+crab%3F&rft.au=Cornia%2C+Paul+B%3BLipsky%2C+Benjamin+A%3BDhaliwal%2C+Gurpreet%3BSaint%2C+Sanjay&rft.aulast=Cornia&rft.aufirst=Paul&rft.date=2004-04-01&rft.volume=350&rft.issue=14&rft.spage=1443&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-19 N1 - Date created - 2004-04-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Self-help organizations for alcohol and drug problems: toward evidence-based practice and policy. AN - 71797516; 15063905 AB - This expert consensus statement reviews evidence on the effectiveness of drug and alcohol self-help groups and presents potential implications for clinicians, treatment program managers and policymakers. Because longitudinal studies associate self-help group involvement with reduced substance use, improved psychosocial functioning, and lessened health care costs, there are humane and practical reasons to develop self-help group supportive policies. Policies described here that could be implemented by clinicians and program managers include making greater use of empirically-validated self-help group referral methods in both specialty and non-specialty treatment settings and developing a menu of locally available self-help group options that are responsive to client's needs, preferences, and cultural background. The workgroup also offered possible self-help supportive policy options (e.g., supporting self-help clearinghouses) for state and federal decision makers. Implementing such policies could strengthen alcohol and drug self-help organizations, and thereby enhance the national response to the serious public health problem of substance abuse. JF - Journal of substance abuse treatment AU - Humphreys, Keith AU - Wing, Stephen AU - McCarty, Dennis AU - Chappel, John AU - Gallant, Lewi AU - Haberle, Beverly AU - Horvath, A Thomas AU - Kaskutas, Lee Ann AU - Kirk, Thomas AU - Kivlahan, Daniel AU - Laudet, Alexandre AU - McCrady, Barbara S AU - McLellan, A Thomas AU - Morgenstern, Jon AU - Townsend, Mike AU - Weiss, Roger AD - SAMHSA/Veterans Health Administration Workgroup on Substance Abuse Self-Help Organizations, c/o Program Evaluation and Resource Center, Veterans Affairs Health Care System (152-MPD), 795 Willow Road, Menlo Park, CA 94025, USA. KNH@stanford.edu Y1 - 2004/04// PY - 2004 DA - April 2004 SP - 151 EP - 8; discussion 159-65 VL - 26 IS - 3 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - United States KW - Evidence-Based Medicine KW - Humans KW - Cost-Benefit Analysis KW - Health Policy KW - Alcoholism -- rehabilitation KW - Quality of Health Care KW - Self-Help Groups -- economics KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71797516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Self-help+organizations+for+alcohol+and+drug+problems%3A+toward+evidence-based+practice+and+policy.&rft.au=Humphreys%2C+Keith%3BWing%2C+Stephen%3BMcCarty%2C+Dennis%3BChappel%2C+John%3BGallant%2C+Lewi%3BHaberle%2C+Beverly%3BHorvath%2C+A+Thomas%3BKaskutas%2C+Lee+Ann%3BKirk%2C+Thomas%3BKivlahan%2C+Daniel%3BLaudet%2C+Alexandre%3BMcCrady%2C+Barbara+S%3BMcLellan%2C+A+Thomas%3BMorgenstern%2C+Jon%3BTownsend%2C+Mike%3BWeiss%2C+Roger&rft.aulast=Humphreys&rft.aufirst=Keith&rft.date=2004-04-01&rft.volume=26&rft.issue=3&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-07-16 N1 - Date created - 2004-04-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nutrition education is positively associated with substance abuse treatment program outcomes. AN - 71787950; 15054346 AB - The scope and types of nutrition services provided in substance abuse treatment programs has not been well defined nor has there been an attempt to determine if associations exist between the provision of nutrition services and substance abuse treatment outcomes. The objectives of this study were to assess the provision (use and extent) of nutrition education in substance abuse treatment programs in facilities that provide a single or two or more substance abuse treatment programs, and to determine the possible association between nutrition intervention and substance abuse treatment program outcome measures (defined as changes in Addiction Severity Index [ASI] composite scores). A descriptive, single, cross-sectional survey of registered dietitians with clinical nutrition program management responsibility (n=152) was used to define the use and extent of nutrition services in substance abuse treatment programs. Positive associations between nutrition services provided, particularly nutrition education services and substance abuse treatment program outcome measures, were detected. When group nutrition/substance abuse education was offered, ASI psychological and medical domain scores improved by 68% and 56%, respectively (P<.05). Individual nutrition/substance abuse education was a predictor of ASI family/social domain change scores improving by 99% (P<.05). In those programs where group nutrition/substance abuse education was offered, moderate to strong correlations with various nutrition education services were observed, specifically in individual nutrition/substance abuse education (r=0.51; P<.05), group normal/nutrition education (r=0.64; P<.01), and individual normal/nutrition education (r=0.46; P<.05). Substance abuse treatment programs offering group nutrition/substance abuse education offered significantly (P<.05) more nutrition services overall. Findings support the position that nutrition education is an essential component of substance abuse treatment programs and can enhance substance abuse treatment outcomes. Dietitians should promote and encourage the inclusion of nutrition education into substance abuse treatment programs. JF - Journal of the American Dietetic Association AU - Grant, Louise P AU - Haughton, Betsy AU - Sachan, Dileep S AD - Nutrition and Food Service, James H Quillen VA Medical Center, Mountain Home, TN, USA. louise.grant2@med.va.gov Y1 - 2004/04// PY - 2004 DA - April 2004 SP - 604 EP - 610 VL - 104 IS - 4 SN - 0002-8223, 0002-8223 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Severity of Illness Index KW - Cross-Sectional Studies KW - Patient Education as Topic KW - Humans KW - Treatment Outcome KW - Surveys and Questionnaires KW - Data Collection KW - Substance-Related Disorders -- therapy KW - Substance Abuse Treatment Centers KW - Health Knowledge, Attitudes, Practice KW - Substance-Related Disorders -- psychology KW - Delivery of Health Care, Integrated KW - Nutritional Sciences -- education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71787950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dietetic+Association&rft.atitle=Nutrition+education+is+positively+associated+with+substance+abuse+treatment+program+outcomes.&rft.au=Grant%2C+Louise+P%3BHaughton%2C+Betsy%3BSachan%2C+Dileep+S&rft.aulast=Grant&rft.aufirst=Louise&rft.date=2004-04-01&rft.volume=104&rft.issue=4&rft.spage=604&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dietetic+Association&rft.issn=00028223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-25 N1 - Date created - 2004-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Systematic ED assessment and treatment of alcohol withdrawal syndromes: a pilot project at a Veterans Affairs Medical Center. AN - 71759152; 15039669 JF - Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association AU - Wojtecki, Cindy A AU - Marron, James AU - Allison, E Jackson AU - Kaul, Pratibha AU - Tyndall, Gary AD - Department of Veterans Affairs Medical Center, Syracuse, NY 13210, USA. Cindy.Wojtecki@med.va.gov Y1 - 2004/04// PY - 2004 DA - April 2004 SP - 134 EP - 140 VL - 30 IS - 2 SN - 0099-1767, 0099-1767 KW - Hypnotics and Sedatives KW - 0 KW - Nursing KW - United States KW - Psychomotor Agitation -- drug therapy KW - Hypnotics and Sedatives -- therapeutic use KW - Humans KW - Psychomotor Agitation -- etiology KW - Pilot Projects KW - Patient Care Team -- organization & administration KW - Male KW - Hospitals, Veterans KW - Emergency Nursing -- methods KW - Substance Withdrawal Syndrome -- complications KW - Nursing Assessment -- standards KW - Emergency Nursing -- instrumentation KW - Substance Withdrawal Syndrome -- diagnosis KW - Practice Guidelines as Topic KW - Substance Withdrawal Syndrome -- drug therapy KW - Alcoholism -- nursing KW - Emergency Nursing -- standards KW - Substance Withdrawal Syndrome -- nursing KW - Alcoholism -- complications KW - Nursing Assessment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71759152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+emergency+nursing%3A+JEN+%3A+official+publication+of+the+Emergency+Department+Nurses+Association&rft.atitle=Systematic+ED+assessment+and+treatment+of+alcohol+withdrawal+syndromes%3A+a+pilot+project+at+a+Veterans+Affairs+Medical+Center.&rft.au=Wojtecki%2C+Cindy+A%3BMarron%2C+James%3BAllison%2C+E+Jackson%3BKaul%2C+Pratibha%3BTyndall%2C+Gary&rft.aulast=Wojtecki&rft.aufirst=Cindy&rft.date=2004-04-01&rft.volume=30&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Journal+of+emergency+nursing%3A+JEN+%3A+official+publication+of+the+Emergency+Department+Nurses+Association&rft.issn=00991767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-25 N1 - Date created - 2004-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fatal acute tumor lysis syndrome, hepatic encephalopathy and flare phenomenon following combined androgen blockade. AN - 71747059; 15017238 JF - The Journal of urology AU - Tanvetyanon, Tawee AU - Choudhury, Abdul M AD - Loyola University Stritch School of Medicine, Maywood and Edward J Hines Veterans Administration Hospital, Hines (AMC), Illinois, USA. tanvety@pol.net Y1 - 2004/04// PY - 2004 DA - April 2004 SP - 1627 VL - 171 IS - 4 SN - 0022-5347, 0022-5347 KW - Androgen Antagonists KW - 0 KW - Goserelin KW - 0F65R8P09N KW - Flutamide KW - 76W6J0943E KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Fatal Outcome KW - Humans KW - Aged KW - Prostatic Neoplasms -- drug therapy KW - Male KW - Androgen Antagonists -- adverse effects KW - Tumor Lysis Syndrome -- etiology KW - Flutamide -- adverse effects KW - Goserelin -- adverse effects KW - Hepatic Encephalopathy -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71747059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Fatal+acute+tumor+lysis+syndrome%2C+hepatic+encephalopathy+and+flare+phenomenon+following+combined+androgen+blockade.&rft.au=Tanvetyanon%2C+Tawee%3BChoudhury%2C+Abdul+M&rft.aulast=Tanvetyanon&rft.aufirst=Tawee&rft.date=2004-04-01&rft.volume=171&rft.issue=4&rft.spage=1627&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-05 N1 - Date created - 2004-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prolactin levels and erectile function in patients treated with risperidone. AN - 66649453; 15206663 AB - Treatment with risperidone is associated with prolactin (PRL) elevation, and PRL elevations are associated with erectile dysfunction (ED). We evaluated whether the PRL elevations caused by risperidone treatment of subjects with schizophrenia are associated with objective measures of erectile function. Subjects were hospitalized for 2 nights, and serum measurements of PRL, total testosterone, and free and weakly bound testosterone were performed in the morning and afternoon of each day. Risperidone levels, parent compound, and 9-hydroxy metabolite levels were drawn on the first day. Erectile function assessments, using the RigiScan, an instrument that measures nocturnal penile tumescence and rigidity, were performed on both nights. Consistent with previous reports, the correlation between total risperidone level and PRL was very high (r = 0.92, df = 12, P < 0.0001), but risperidone did not appear to affect either testosterone (r = 0.29, df = 5, P = 0.51) or free and weakly bound testosterone (r = -0.11, df = 10, P = 0.72). Contrary to expectations, PRL levels from the second night were positively correlated with erectile function (r = 0.68, df = 9, P = 0.022). Using objective measures, we were unable to confirm a detrimental association between PRL levels and male erectile function. These results are tentative given the small sample. JF - Journal of clinical psychopharmacology AU - Spollen, John J AU - Wooten, Robert G AU - Cargile, Christopher AU - Bartztokis, George AD - Central Arkansas Veterans Health System, North Little Rock, VA, AR 72114, USA. John.Spollen@med.va.gov Y1 - 2004/04// PY - 2004 DA - April 2004 SP - 161 EP - 166 VL - 24 IS - 2 SN - 0271-0749, 0271-0749 KW - Antipsychotic Agents KW - 0 KW - Testosterone KW - 3XMK78S47O KW - Prolactin KW - 9002-62-4 KW - Risperidone KW - L6UH7ZF8HC KW - Index Medicus KW - Circadian Rhythm -- physiology KW - Affect -- drug effects KW - Humans KW - Testosterone -- blood KW - Adult KW - Aged KW - Schizophrenia -- drug therapy KW - Middle Aged KW - Penile Erection -- drug effects KW - Adolescent KW - Schizophrenia -- complications KW - Male KW - Erectile Dysfunction -- chemically induced KW - Prolactin -- blood KW - Erectile Dysfunction -- blood KW - Risperidone -- adverse effects KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66649453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Prolactin+levels+and+erectile+function+in+patients+treated+with+risperidone.&rft.au=Spollen%2C+John+J%3BWooten%2C+Robert+G%3BCargile%2C+Christopher%3BBartztokis%2C+George&rft.aulast=Spollen&rft.aufirst=John&rft.date=2004-04-01&rft.volume=24&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-07-06 N1 - Date created - 2004-06-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Psychopharmacol. 2005 Aug;25(4):393-4 [16012288] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Short-course treatment regimen to identify potential antituberculous agents in a murine model of tuberculosis AN - 17938364; 5894589 AB - Objective: Designing a more rapid method to test antimycobacterial agents in a murine model would significantly improve the drug development process. We describe a short-course in vivo treatment model that could be used to screen potential antituberculous drugs. Methods: In this model, C57BL/6 mice were infected intranasally with similar to 10 super(6) viable Mycobacterium tuberculosis organisms. Treatment began 1 day post-infection and was administered for 2 days. Mice were euthanized 3 days post-infection and their right lungs were removed and cell counts determined. Several antimycobacterial agents with superior in vivo activity in a 4 week treatment model were tested to evaluate the short-course treatment model. Results: Two days of isoniazid (25 mg/kg), rifampicin (20 mg/kg), PNU-100480 (100 mg/kg), gatifloxacin (100 mg/kg), levofloxacin (100 mg/kg) and sparfloxacin (100 mg/kg) were all able to significantly reduce the mycobacterial load in the lungs compared with the untreated control mice. Conclusions: Use of this model to screen potential chemotherapeutic agents will save time and resources. JF - Journal of Antimicrobial Chemotherapy AU - Shoen, C M AU - DeStefano AU - Sklaney, M R AU - Monica, B J AU - Slee, A M AU - Cynamon, M H AD - VAMC, 800 Irving Avenue, Syracuse, NY 13210, USA, michael.cynamon@med.va.gov Y1 - 2004/04// PY - 2004 DA - Apr 2004 SP - 641 EP - 645 VL - 53 IS - 4 SN - 0305-7453, 0305-7453 KW - mice KW - Microbiology Abstracts B: Bacteriology KW - Rifampin KW - Sparfloxacin KW - Chemotherapy KW - Levofloxacin KW - Lung diseases KW - Antitubercular agents KW - Gatifloxacin KW - Isoniazid KW - Mycobacterium tuberculosis KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17938364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Short-course+treatment+regimen+to+identify+potential+antituberculous+agents+in+a+murine+model+of+tuberculosis&rft.au=Shoen%2C+C+M%3BDeStefano%3BSklaney%2C+M+R%3BMonica%2C+B+J%3BSlee%2C+A+M%3BCynamon%2C+M+H&rft.aulast=Shoen&rft.aufirst=C&rft.date=2004-04-01&rft.volume=53&rft.issue=4&rft.spage=641&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkh124 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Isoniazid; Rifampin; Sparfloxacin; Levofloxacin; Gatifloxacin; Chemotherapy; Antitubercular agents; Lung diseases DO - http://dx.doi.org/10.1093/jac/dkh124 ER - TY - CPAPER T1 - Use of intravenous immunoglobulin in stevens-johnson syndrome AN - 39837726; 3844504 AU - Gowda, V C AU - Klaustermeyer, W B Y1 - 2004/03/26/ PY - 2004 DA - 2004 Mar 26 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39837726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Use+of+intravenous+immunoglobulin+in+stevens-johnson+syndrome&rft.au=Gowda%2C+V+C%3BKlaustermeyer%2C+W+B&rft.aulast=Gowda&rft.aufirst=V&rft.date=2004-03-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Academy of Allergy, Asthma & Immunology, 611 East Wells Street, Milwaukee, WI 53202, USA; phone: 414-272-6071; email: info@aaaai.org; URL: www.aaaai.org N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Outcomes of Computer-Provided Treatment for Aphasia AN - 85584146; 200409571 AB - Computers have become a familiar component of aphasia treatment over the past 20 years. Published research continues to indicate the influence computerized treatment may have on improving language performance of aphasic adults. As a result of the move to develop evidenced-based clinical guidelines, there is a need to evaluate the research methodology & the level of evidence provided by computerized interventions for aphasia. The purposes of this paper are to evaluate examples of reports in the computerized treatment for aphasia outcomes research literature by applying precise definitions of the treatment outcome research terminology, placing the examples within the context of the five-phase treatment outcomes research model, applying a level of evidence scale to rate the evidence provided by the selected examples, & speculating where we are & where we may need to go in demonstrating the influence of computer-provided treatment on improvement in aphasia. We applied Robey & Schultz's (1998) model for conducting clinical-outcome research in aphasia & the level of evidence scale developed by the American Academy of Neurology (1994) to the results of computer-provided aphasia treatment studies. Eight Phase 1 studies, three series of Phase 2 studies, & one Phase 3 study are described as examples. While several Phase 1 & 2 studies imply that computer-provided treatment is active in the treatment of people with aphasia, evidence to support the efficacy of computerized treatment for adults with aphasia is based on a single Phase 3 study. Additional Phase 3 studies are needed to demonstrate the efficacy of additional treatment software, & Phase 4 & Phase 5 studies are necessary to demonstrate the effectiveness & efficiency of computerized treatment for people with aphasia. 38 References. Adapted from the source document JF - Aphasiology AU - Wertz, Robert T AU - Katz, Richard C AD - VA Medical Center, Nashville, TN robert.wertz@med.va.gov Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 229 EP - 244 VL - 18 IS - 3 SN - 0268-7038, 0268-7038 KW - Computer Software (14360) KW - Aphasia (03400) KW - Computer Applications (14150) KW - Research Design (72950) KW - Adults (00600) KW - Speech Therapy (83200) KW - article KW - 6414: language-pathological and normal; aphasia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85584146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Outcomes+of+Computer-Provided+Treatment+for+Aphasia&rft.au=Wertz%2C+Robert+T%3BKatz%2C+Richard+C&rft.aulast=Wertz&rft.aufirst=Robert&rft.date=2004-03-01&rft.volume=18&rft.issue=3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2004-08-01 N1 - Last updated - 2016-09-27 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Computer Applications (14150); Adults (00600); Speech Therapy (83200); Computer Software (14360); Research Design (72950) ER - TY - JOUR T1 - Hearing specific and generic measures of the psychosocial impact of hearing aids. AN - 85382106; pmid-15119464 AB - Hearing-specific and generic measures of hearing aid outcome were examined in order (a) to determine their relative sensitivity to hearing aid use and (b) to examine the relationship between pre-hearing aid use expectations and post-use outcomes. Ninety-two hearing-impaired individuals completed some combination of the Abbreviated Profile of Hearing Aid Benefit, Expected Consequences of Hearing Aid Ownership (ECHO), Satisfaction with Amplification in Daily Life (SADL), and Psychosocial Impact of Assistive Devices Scale, and provided reports of their daily and lifetime hearing aid use. In general, (a) the longer individuals wear hearing aids, the more positive the reported outcome, and (b) ECHO scores of non-hearing aid users are higher than SADL scores of new hearing aid users (six weeks to one year of use) but are similar to those obtained from experienced users (greater than one year of use). Between-questionnaire comparisons showed the generic measure to be as sensitive as the hearing aid specific measures. We suggest that generic measures have some advantages over hearing specific measures but that each has a place in the clinic. JF - Journal of the American Academy of Audiology AU - Saunders, Gabrielle H AU - Jutai, Jeffrey W AD - National Center for Rehabilitative Auditory Research, 3710 SW US Veterans Hospital Road, Portland, OR 97207, USA. Gabrielle.saunders@med.va.gov Y1 - 2004/03// PY - 2004 DA - Mar 2004 SP - 238 EP - 248 VL - 15 IS - 3 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Female KW - *Hearing Aids: psychology KW - Hearing Loss: psychology KW - *Hearing Loss: rehabilitation KW - Humans KW - Male KW - Multivariate Analysis KW - *Outcome Assessment (Health Care) KW - *Patient Satisfaction KW - *Quality of Life KW - Questionnaires KW - Speech Perception: physiology KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85382106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Hearing+specific+and+generic+measures+of+the+psychosocial+impact+of+hearing+aids.&rft.au=Saunders%2C+Gabrielle+H%3BJutai%2C+Jeffrey+W&rft.aulast=Saunders&rft.aufirst=Gabrielle&rft.date=2004-03-01&rft.volume=15&rft.issue=3&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: J Am Acad Audiol. 2004 Mar;15(3):183[15119459] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Hepatitis C tested prevalence and comorbidities among veterans in the US Northwest. AN - 85381268; pmid-15128077 AB - (1) Investigate the epidemiology of hepatitis C virus infection among patients seen in the Veterans Administration Northwest Network; (2) examine time trends in testing practices and results; and (3) estimate the prevalence of hepatitis C virus infection among active patients.Hepatitis C virus infection causes chronic hepatitis and cirrhosis and is a leading cause of end-stage liver disease. Hepatitis C virus antibodies are estimated to be present in 1.8% of the US population, but reports of its prevalence among US veterans range from 1.7 to 35%.Retrospective review of computerized medical records of veterans tested for hepatitis C from October 1994 through December 2000 (n = 37,938) at 8 Northwest Veterans Administration Medical Centers.Among tested veterans, 8230 (21.7%) had evidence of hepatitis C virus infection. The number of patients tested increased annually from 2335 to 18,191, while the proportion with first-time positive hepatitis C test results decreased from 35 to 10%. This drop in tested prevalence was associated with a shift away from testing individuals at highest risk--those with positive hepatitis B serostatus, repeatedly elevated alanine transaminase levels, and drug use disorder diagnoses. We estimate that 11.4% of the Northwest Network veteran users are hepatitis C virus seropositive, with a lower bound of 4.0% and upper bound of 19.5%.Although estimates of hepatitis C virus infection rates among veteran users of the Veterans Administration system remain higher than those for the general population, changes in testing practice make generalizations from earlier studies hazardous. JF - Journal of clinical gastroenterology AU - Sloan, Kevin L AU - Straits-Tröster, Kristy A AU - Dominitz, Jason A AU - Kivlahan, Daniel R AD - Veterans Affairs Puget Sound Health Care System, Mental Health Service and the Addictions Treatment Center, Seattle, WA 98108, USA. Kevin.Sloan@med.va.gov Y1 - 2004/03// PY - 2004 DA - Mar 2004 SP - 279 EP - 284 VL - 38 IS - 3 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Comorbidity KW - Female KW - *Hepatitis C: epidemiology KW - Humans KW - Male KW - Middle Aged KW - Northwestern United States: epidemiology KW - Prevalence KW - Retrospective Studies KW - Risk Factors KW - Seroepidemiologic Studies KW - *Veterans: statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85381268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Hepatitis+C+tested+prevalence+and+comorbidities+among+veterans+in+the+US+Northwest.&rft.au=Sloan%2C+Kevin+L%3BStraits-Tr%C3%B6ster%2C+Kristy+A%3BDominitz%2C+Jason+A%3BKivlahan%2C+Daniel+R&rft.aulast=Sloan&rft.aufirst=Kevin&rft.date=2004-03-01&rft.volume=38&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Consequences of noise- or styrene-induced cochlear damages on glutamate decarboxylase levels in the rat inferior colliculus. AN - 85374610; pmid-14987755 AB - Both noise and styrene can injure the cochlea, resulting in a reduction of incoming inputs from the cochlea to the central nervous system. In addition, styrene is known to have neurotoxic properties at high doses. The loss of inputs caused by noise has been shown to be compensated by a new equilibrium between excitatory and inhibitory influences within the inferior colliculus (IC). The main goal of this study was to determine whether styrene-induced hearing loss could also be counterbalanced by a GABAergic adjustment in the IC. For this purpose, rats were exposed to noise (97 dB SPL octave band noise centered at 8 kHz), or to a non-neurotoxic dose of styrene for 4 weeks (700 ppm, 6 h/day, 5 days/week). Auditory sensitivity was tested by evoked potentials, and cochlear damage was assessed by hair cell counts. Glutamate decarboxylase (GAD) was dosed in the IC by indirect competitive enzyme-linked immunosorbent assay. Both noise and styrene caused PTSs that reached 27.0 and 14.6 dB respectively. Outer hair cell (OHC) loss caused by noise did not exceed 9% in the first row, on the other hand OHC loss induced by styrene reached 63% in the third row. Only the noise caused a decrease of GAD of 37% compared to that measured in the controls. No significant modification of GAD concentration has been shown after styrene exposure. Thus, central compensation for cochlear damage may depend on the nature of the ototoxic agent. Unless styrene directly affects IC function, it is reasonable to assume that noise causes a modification of inhibitory neurotransmission within the structure because of impairment of afferent supply to the auditory brainstem. The present findings suggest that central compensation for cochlear damage can preferably occur when afferent fibers are altered. JF - Hearing research AU - Pouyatos, Benoît AU - Morel, Georges AU - Lambert-Xolin, Anne-Marie AU - Maguin, Katy AU - Campo, Pierre AD - Institut National de Recherche et de Sécurité, Laboratoire de Neurotoxicologie, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre, France. benoit.pouyatos@med.va.gov Y1 - 2004/03// PY - 2004 DA - Mar 2004 SP - 83 EP - 91 VL - 189 IS - 1-2 SN - 0378-5955, 0378-5955 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Audiometry KW - Auditory Threshold KW - *Cochlea: drug effects KW - *Cochlea: injuries KW - Cochlea: pathology KW - Enzyme-Linked Immunosorbent Assay KW - Evoked Potentials, Auditory KW - *Glutamate Decarboxylase: metabolism KW - Hair Cells, Auditory: pathology KW - *Hearing Loss: chemically induced KW - Hearing Loss: diagnosis KW - Hearing Loss: enzymology KW - Hearing Loss: pathology KW - Hearing Loss, Noise-Induced: diagnosis KW - Hearing Loss, Noise-Induced: physiopathology KW - Hearing Tests KW - *Inferior Colliculi: enzymology KW - *Isoenzymes: metabolism KW - Male KW - *Noise KW - Rats KW - Rats, Long-Evans KW - *Styrene: pharmacology KW - *Wounds and Injuries: enzymology KW - Wounds and Injuries: pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85374610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hearing+research&rft.atitle=Consequences+of+noise-+or+styrene-induced+cochlear+damages+on+glutamate+decarboxylase+levels+in+the+rat+inferior+colliculus.&rft.au=Pouyatos%2C+Beno%C3%AEt%3BMorel%2C+Georges%3BLambert-Xolin%2C+Anne-Marie%3BMaguin%2C+Katy%3BCampo%2C+Pierre&rft.aulast=Pouyatos&rft.aufirst=Beno%C3%AEt&rft.date=2004-03-01&rft.volume=189&rft.issue=1-2&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Hearing+research&rft.issn=03785955&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation. AN - 80177505; 14978093 AB - IL-12 has been reported to affect thymic T cell selection, but the role of IL-12 in thymic involution has not been studied. We found that in vivo, IL-12b knockout (IL-12b(-/-)) mice exhibited accelerated thymic involution compared with wild-type (WT) B6 mice. This is characterized by an increase in thymocytes with the early development stage phenotype of CD25(-)CD44(+)CD4(-)CD8(-) in aged IL-12b(-/-) mice. Histologically, there were accelerated degeneration of thymic extracellular matrix and blood vessels, a significantly decreased thymic cortex/medulla ratio, and increased apoptotic cells in aged IL-12b(-/-) mice compared with WT mice. There was, however, no apparent defect in thymic structure and thymocyte development in young IL-12(-/-) mice. These results suggest the importance of IL-12 in maintaining thymic integrity and function during the aging process. Surprisingly, in WT B6 mice, there was no age-related decrease in the levels of IL-12 produced from thymic dendritic cells. Stimulation of thymocytes with IL-12 alone also did not enhance the thymocyte proliferative response in vitro. IL-12, however, provided a strong synergistic effect to augment the IL-7 or IL-2 induced thymocyte proliferative response, especially in aged WT and IL-12b(-/-) mice. Our data strongly support the role of IL-12 as an enhancement cytokine, which acts through its interactions with other cytokines to maintain thymic T cell function and development during aging. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Li, Lina AU - Hsu, Hui-Chen AU - Stockard, Cecil R AU - Yang, PingAr AU - Zhou, Juling AU - Wu, Qi AU - Grizzle, William E AU - Mountz, John D AD - Department of Pathology, Veterans Administration Medical Center, Birmingham, AL 35233, USA. Y1 - 2004/03/01/ PY - 2004 DA - 2004 Mar 01 SP - 2909 EP - 2916 VL - 172 IS - 5 SN - 0022-1767, 0022-1767 KW - Adjuvants, Immunologic KW - 0 KW - Interleukin-12 Subunit p40 KW - Interleukin-2 KW - Interleukin-7 KW - Protein Subunits KW - Interleukin-12 KW - 187348-17-0 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Apoptosis -- immunology KW - Mice KW - Mice, Knockout KW - Apoptosis -- genetics KW - Protein Subunits -- genetics KW - Cell Division -- immunology KW - Cells, Cultured KW - Signal Transduction -- genetics KW - Protein Subunits -- physiology KW - Mice, Inbred C57BL KW - Signal Transduction -- immunology KW - Protein Subunits -- deficiency KW - Drug Synergism KW - Aging -- immunology KW - Aging -- genetics KW - Female KW - T-Lymphocyte Subsets -- cytology KW - Thymus Gland -- cytology KW - Interleukin-2 -- pharmacology KW - Adjuvants, Immunologic -- physiology KW - Thymus Gland -- pathology KW - Interleukin-12 -- deficiency KW - Adjuvants, Immunologic -- genetics KW - Interleukin-7 -- pharmacology KW - Adjuvants, Immunologic -- biosynthesis KW - Thymus Gland -- immunology KW - Adjuvants, Immunologic -- deficiency KW - Interleukin-12 -- biosynthesis KW - Interleukin-12 -- physiology KW - T-Lymphocyte Subsets -- immunology KW - Interleukin-12 -- genetics KW - T-Lymphocyte Subsets -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80177505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=IL-12+inhibits+thymic+involution+by+enhancing+IL-7-+and+IL-2-induced+thymocyte+proliferation.&rft.au=Li%2C+Lina%3BHsu%2C+Hui-Chen%3BStockard%2C+Cecil+R%3BYang%2C+PingAr%3BZhou%2C+Juling%3BWu%2C+Qi%3BGrizzle%2C+William+E%3BMountz%2C+John+D&rft.aulast=Li&rft.aufirst=Lina&rft.date=2004-03-01&rft.volume=172&rft.issue=5&rft.spage=2909&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-06-21 N1 - Date created - 2004-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acrylonitrile potentiates noise-induced hearing loss in rat. AN - 80176249; 14669069 AB - Acrylonitrile, one of the 50 most commonly produced industrial chemicals, has recently been identified as a promoter of noise-induced hearing loss (NIHL). This agent has the potential to produce oxidative stress through multiple pathways. We hypothesize that acrylonitrile potentiates NIHL as a consequence of oxidative stress. The objectives of this study were to characterize acrylonitrile exposure conditions that promote permanent NIHL in rats and determine the ability of this nitrile to produce auditory dysfunction by itself. Additionally, we sought to determine whether a spin-trap agent that can form adducts with ROS would protect against the effects of acrylonitrile. Acrylonitrile administration produced significant elevation in NIHL detected as a loss in compound action potential sensitivity. The effect was particularly robust for high-frequency tones and particularly when acrylonitrile and noise were given on repeated occasions. Acrylonitrile by itself did not disrupt threshold sensitivity. Administration of the spin-trap agent phenyl- N- tert-butylnitrone (PBN), given to rats prior to acrylonitrile and noise, did block the elevation of NIHL by acrylonitrile. However, PBN at the dose and time interval given was ineffective in protecting auditory function in subjects exposed to noise alone. The results suggest that oxidative stress may play a role in the promotion of NIHL by acrylonitrile. JF - Journal of the Association for Research in Otolaryngology : JARO AU - Fechter, Laurence D AU - Gearhart, Caroline AU - Shirwany, Najeeb A AD - Research Service Jerry Pettis Memorial Veterans Medical Center, Loma Linda, CA 92357, USA. larry.fechter@med.va.gov Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 90 EP - 98 VL - 5 IS - 1 SN - 1525-3961, 1525-3961 KW - Carcinogens KW - 0 KW - Acrylonitrile KW - MP1U0D42PE KW - Index Medicus KW - Rats KW - Animals KW - Rats, Long-Evans KW - Auditory Threshold -- drug effects KW - Oxidative Stress -- drug effects KW - Noise -- adverse effects KW - Male KW - Hearing Loss, Noise-Induced -- physiopathology KW - Acrylonitrile -- toxicity KW - Carcinogens -- toxicity KW - Hearing Loss, Noise-Induced -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80176249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Association+for+Research+in+Otolaryngology+%3A+JARO&rft.atitle=Acrylonitrile+potentiates+noise-induced+hearing+loss+in+rat.&rft.au=Fechter%2C+Laurence+D%3BGearhart%2C+Caroline%3BShirwany%2C+Najeeb+A&rft.aulast=Fechter&rft.aufirst=Laurence&rft.date=2004-03-01&rft.volume=5&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Association+for+Research+in+Otolaryngology+%3A+JARO&rft.issn=15253961&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-10-08 N1 - Date created - 2004-02-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hear Res. 1994 Oct;80(1):25-30 [7852200] Hear Res. 1987;26(1):37-43 [3558142] Eur Arch Otorhinolaryngol. 1995;252(8):504-8 [8719596] Hear Res. 1996 Dec 1;102(1-2):90-8 [8951454] Toxicol Appl Pharmacol. 1997 Jan;142(1):47-55 [9007033] Acta Otolaryngol. 1997 Mar;117(2):232-8 [9105457] Neurotoxicol Teratol. 1997 Mar-Apr;19(2):129-40 [9136129] Fundam Appl Toxicol. 1997 Apr;36(2):149-56 [9143484] Fundam Appl Toxicol. 1997 Jul;38(1):101-6 [9268609] Am J Otol. 1997 Sep;18(5):559-71 [9303151] Scand Audiol. 1997;26(3):141-9 [9309809] Scand J Work Environ Health. 1997 Aug;23(4):289-98 [9322820] Hear Res. 1997 Dec;114(1-2):75-82 [9447921] Toxicol Sci. 1998 Mar;42(1):28-35 [9538045] Brain Res. 1999 Jan 9;815(2):317-25 [9878807] Otolaryngol Head Neck Surg. 1998 Dec;119(6):581-7 [9852529] Hear Res. 1999 Dec;138(1-2):13-28 [10575111] Acta Otolaryngol. 1988 Jan-Feb;105(1-2):56-63 [3341162] Ann Otol Rhinol Laryngol. 1988 Jan-Feb;97(1):36-41 [3341701] Hear Res. 1987 Dec 31;31(3):217-22 [3436849] Hear Res. 1988 Jul 1;34(1):39-47 [3403384] Free Radic Res Commun. 1990;9(3-6):317-23 [2387499] Hear Res. 1990 Dec;50(1-2):211-23 [2076973] Anat Rec. 1991 May;230(1):136-45 [2064025] Scand J Work Environ Health. 1993 Aug;19(4):245-54 [8235513] Otolaryngol Head Neck Surg. 1993 Dec;109(6):1052-6 [8265189] Hear Res. 1994 Apr;74(1-2):217-20 [8040090] Hear Res. 1994 Jun 15;77(1-2):81-7 [7928740] Arch Environ Health. 1994 Sep-Oct;49(5):359-65 [7944568] Toxicol Sci. 1999 Feb;47(2):195-202 [10220857] Hear Res. 1999 Jun;132(1-2):149-59 [10392557] Hear Res. 2001 May;155(1-2):1-8 [11335071] Audiol Neurootol. 1999 Sep-Oct;4(5):229-36 [10436315] Audiol Neurootol. 1999 Sep-Oct;4(5):237-46 [10436316] J Comp Neurol. 1999 Oct 11;413(1):101-12 [10464373] IARC Monogr Eval Carcinog Risks Hum. 1999;71 Pt 1:43-108 [10476445] Hear Res. 1999 Dec;138(1-2):181-91 [10575125] Ann N Y Acad Sci. 1999 Nov 28;884:368-80 [10842607] Hear Res. 2000 Aug;146(1-2):28-34 [10913881] Toxicol Appl Pharmacol. 2000 Sep 1;167(2):125-31 [10964763] Brain Res. 2000 Sep 29;878(1-2):163-73 [10996147] Toxicol Appl Pharmacol. 2001 Jul 1;174(1):27-34 [11437646] J Assoc Res Otolaryngol. 2000 Nov;1(3):243-54 [11545230] Toxicol Sci. 2002 Mar;66(1):131-8 [11861980] Laryngoscope. 2002 Sep;112(9):1515-32 [12352659] Drug Metab Dispos. 2003 Feb;31(2):147-52 [12527695] Toxicol Sci. 2003 Sep;75(1):117-23 [12832658] J Biol Chem. 1973 May 25;248(10):3582-92 [4702877] Otolaryngology. 1978 May-Jun;86(3 Pt 1):ORL400-4 [112529] J Toxicol Environ Health. 1980 Mar;6(2):273-82 [7392095] Arch Otolaryngol. 1980 Dec;106(12):744-50 [7436850] Drug Metab Dispos. 1981 May-Jun;9(3):246-9 [6113934] Annu Rev Pharmacol Toxicol. 1984;24:451-81 [6428300] Fundam Appl Toxicol. 1995 Jul;26(2):293-300 [7589918] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Serotonin syndrome resulting from coadministration of tramadol, venlafaxine, and mirtazapine. AN - 80165355; 14970364 AB - To report a case of serotonin syndrome (SS) resulting from the addition of tramadol to a medication regimen of venlafaxine and mirtazapine. A 47-year-old white man receiving combined mirtazapine and venlafaxine therapy for major depressive disorder developed agitation, confusion, severe shivering, diaphoresis, myoclonus, hyperreflexia, mydriasis, tachycardia, and fever on coadministration of tramadol for chronic pain. An objective causality assessment revealed that the addition of tramadol was the probable cause of the adverse reaction. SS is a potentially fatal iatrogenic complication of serotonergic polypharmacy. Considered idiopathic in presentation, it typically appears after initiation or dose escalation of the offending agent to a regimen including other serotonergic agents. All drugs that directly or indirectly increase central serotonin neurotransmission at postsynaptic 5-HT(1A) and 5-HT(2A) receptors can produce SS. Individual vulnerability appears to play a role in the development of SS. It is likely that the activation of 5-HT(1A) receptors by mirtazapine, the combined serotonin reuptake inhibition by venlafaxine and tramadol, as well as possible serotonin release by tramadol, contributed to the development of SS in this case. It is vital that clinicians are aware of the potential for SS when psychotropic and nonpsychotropic agents are coadministered to certain patients, such as those with both depression and chronic pain. JF - The Annals of pharmacotherapy AU - Houlihan, David J AD - Veterans Affairs Medical Center, 500 E. Veterans St., Tomah, WI 54660-9912, USA. David.Houlihan@med.va.gov Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 411 EP - 413 VL - 38 IS - 3 SN - 1060-0280, 1060-0280 KW - Analgesics, Opioid KW - 0 KW - Antidepressive Agents KW - Cyclohexanols KW - Mianserin KW - 250PJI13LM KW - Tramadol KW - 39J1LGJ30J KW - Venlafaxine Hydrochloride KW - 7D7RX5A8MO KW - mirtazapine KW - A051Q2099Q KW - Index Medicus KW - Humans KW - Polypharmacy KW - Middle Aged KW - Male KW - Pain -- drug therapy KW - Mianserin -- adverse effects KW - Tramadol -- adverse effects KW - Depressive Disorder -- drug therapy KW - Antidepressive Agents -- adverse effects KW - Analgesics, Opioid -- adverse effects KW - Serotonin Syndrome -- chemically induced KW - Cyclohexanols -- adverse effects KW - Mianserin -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80165355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Serotonin+syndrome+resulting+from+coadministration+of+tramadol%2C+venlafaxine%2C+and+mirtazapine.&rft.au=Houlihan%2C+David+J&rft.aulast=Houlihan&rft.aufirst=David&rft.date=2004-03-01&rft.volume=38&rft.issue=3&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-25 N1 - Date created - 2004-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cardiac medications and their association with cardiovascular events in incident dialysis patients: cause or effect? AN - 80147943; 14871422 AB - There are no large randomized, controlled trials evaluating the efficacy of common cardioprotective medications on cardiovascular outcomes in the dialysis population. We aimed to determine the association between cardioprotective medications and a composite end point of cardiovascular events or death in an incident dialysis cohort. Medicare claims data were utilized to determine outcomes in participants of the Dialysis Morbidity and Mortality Wave 2 cohort. Information was gathered at baseline regarding demographics, comorbidities, medication use, and lab data. Cox proportional hazard models were developed to determine the association between cardioprotective medication use at baseline and the subsequent development of a composite of cardiovascular events or death. Two thousand two hundred thirty-four of 3044 individuals experienced a cardiovascular event or death. Use of the following medications at baseline was associated with an increased event rate: nitrates, antiplatelet agents, and warfarin. There was no association between the use of angiotensin-converting enzyme inhibitors, beta-blockers, or 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and a composite cardiovascular outcome or death. Only use of a calcium channel blocker at baseline was associated with a reduced risk of events. This beneficial association did not persist when death was excluded as an outcome. Many of the associations observed varied substantially depending on the outcome utilized. Use of cohort data to determine an association between medication use and outcome is difficult because the indication for the medication confounds the observed association. Before widespread practice changes, rigorous clinical trials of common cardioprotective medications on cardiovascular morbidity and mortality in dialysis should be performed. JF - Kidney international AU - Ishani, Areef AU - Herzog, Charles A AU - Collins, Allan J AU - Foley, Robert N AD - Department of Medicine, Minneapolis Veterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota 55417, USA. areef.ishani@me.va.gov Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 1017 EP - 1025 VL - 65 IS - 3 SN - 0085-2538, 0085-2538 KW - Adrenergic beta-Antagonists KW - 0 KW - Angiotensin-Converting Enzyme Inhibitors KW - Calcium Channel Blockers KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Platelet Aggregation Inhibitors KW - Index Medicus KW - Platelet Aggregation Inhibitors -- adverse effects KW - Peripheral Vascular Diseases -- drug therapy KW - Humans KW - Adrenergic beta-Antagonists -- adverse effects KW - Aged KW - Stroke -- mortality KW - Comorbidity KW - Cause of Death KW - Multivariate Analysis KW - Adrenergic beta-Antagonists -- administration & dosage KW - Stroke -- drug therapy KW - Myocardial Infarction -- mortality KW - Heart Failure -- prevention & control KW - Adult KW - Peripheral Vascular Diseases -- prevention & control KW - Myocardial Infarction -- prevention & control KW - Male KW - Angiotensin-Converting Enzyme Inhibitors -- administration & dosage KW - Heart Failure -- drug therapy KW - Angiotensin-Converting Enzyme Inhibitors -- adverse effects KW - Heart Failure -- mortality KW - Incidence KW - Middle Aged KW - Stroke -- prevention & control KW - Peripheral Vascular Diseases -- mortality KW - Female KW - Proportional Hazards Models KW - Myocardial Infarction -- drug therapy KW - Platelet Aggregation Inhibitors -- administration & dosage KW - Cardiovascular Diseases -- mortality KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- administration & dosage KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- adverse effects KW - Calcium Channel Blockers -- adverse effects KW - Calcium Channel Blockers -- administration & dosage KW - Kidney Failure, Chronic -- mortality KW - Cardiovascular Diseases -- drug therapy KW - Cardiovascular Diseases -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80147943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Cardiac+medications+and+their+association+with+cardiovascular+events+in+incident+dialysis+patients%3A+cause+or+effect%3F&rft.au=Ishani%2C+Areef%3BHerzog%2C+Charles+A%3BCollins%2C+Allan+J%3BFoley%2C+Robert+N&rft.aulast=Ishani&rft.aufirst=Areef&rft.date=2004-03-01&rft.volume=65&rft.issue=3&rft.spage=1017&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-10-08 N1 - Date created - 2004-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epigenetic alterations in head and neck cancer: prevalence, clinical significance, and implications. AN - 80134901; 14751093 AB - Head and neck cancers are a group of malignancies with diverse biologic behaviors and a strong, well-established association with tobacco and alcohol use. Although the hunt for genetic alterations in head and neck cancer has continued in the past two decades, with unequivocal proof of a genetic role in multistage head and neck carcinogenesis, epigenetic alteration in association with promoter CpG island hypermethylation has emerged in the past few years as one of the most active areas of cancer research. It is now firmly believed that, in cancer cells, promoter CpG island hypermethylation (epigenetic alteration) represents a bona fide alternative mechanism, as opposed to genetic factors, such as gene mutations and deletion, in the inactivation of many tumor-suppressor genes. It is also realized that epigenetic and genetic factors often work together, affecting multiple cellular pathways, such as cell-cycle regulation, DNA repair, apoptosis, angiogenesis, and cell-to-cell adhesion, during the process of tumor growth and progression. JF - Current oncology reports AU - Fan, Chun-Yang AD - Department of Pathology and Otolaryngology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, 4300 West 7th Street (113/LR), Little Rock, AR 72205, USA. chun.fan@med.va.gov Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 152 EP - 161 VL - 6 IS - 2 SN - 1523-3790, 1523-3790 KW - Index Medicus KW - Cell Physiological Phenomena KW - DNA Methylation KW - Gene Silencing KW - Humans KW - Prevalence KW - Epigenesis, Genetic -- genetics KW - CpG Islands -- genetics KW - Head and Neck Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80134901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+oncology+reports&rft.atitle=Epigenetic+alterations+in+head+and+neck+cancer%3A+prevalence%2C+clinical+significance%2C+and+implications.&rft.au=Fan%2C+Chun-Yang&rft.aulast=Fan&rft.aufirst=Chun-Yang&rft.date=2004-03-01&rft.volume=6&rft.issue=2&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Current+oncology+reports&rft.issn=15233790&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-12 N1 - Date created - 2004-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Infiltrative lung disease due to noncytotoxic agents. AN - 71958485; 15062596 AB - Pulmonary complications of therapy for RA or other benign conditions are often difficult to diagnose and treat. Clinical presentation of lung disease that is due to noncytotoxic drugs may vary from a mild, nonspecific cough to fulminant respiratory failure. The differential diagnosis of pulmonary disease should include drug toxicity, progression of the primary illness, and opportunistic infection. An objective assessment of the patient's baseline pulmonary status, as well as his treatment history, is crucial to differentiate drug-induced pathology from the primary process. Diagnostic work-up should include chest radiograph, repeat pulmonary function testing, and high-resolution CT of the chest. Bronchoscopy for tissue pathology or specific BAL cytokine markers also may yield useful information; occasionally, open-lung biopsy is required. If pulmonary disease that results from noncytotoxic drug therapy is suspected, the drug should be discontinued until the disease process is understood clearly. JF - Clinics in chest medicine AU - Lock, Brion J AU - Eggert, Michael AU - Cooper, J Allen D AD - Pulmonary Section, Birmingham Veterans Administration Medical Center, AL 35233, USA. Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 47 EP - 52 VL - 25 IS - 1 SN - 0272-5231, 0272-5231 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Antirheumatic Agents KW - Narcotics KW - Organogold Compounds KW - Hydrochlorothiazide KW - 0J48LPH2TH KW - Aspirin KW - R16CO5Y76E KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Methotrexate -- adverse effects KW - Iatrogenic Disease KW - Aspirin -- adverse effects KW - Syndrome KW - Humans KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Antirheumatic Agents -- adverse effects KW - Narcotics -- adverse effects KW - Lung Diseases, Interstitial -- chemically induced KW - Kidney Diseases -- chemically induced KW - Hydrochlorothiazide -- adverse effects KW - Lung Diseases -- chemically induced KW - Lung Diseases -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71958485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+chest+medicine&rft.atitle=Infiltrative+lung+disease+due+to+noncytotoxic+agents.&rft.au=Lock%2C+Brion+J%3BEggert%2C+Michael%3BCooper%2C+J+Allen+D&rft.aulast=Lock&rft.aufirst=Brion&rft.date=2004-03-01&rft.volume=25&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Clinics+in+chest+medicine&rft.issn=02725231&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-12 N1 - Date created - 2004-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enfuvirtide: a fusion inhibitor for the treatment of HIV infection. AN - 71870535; 15110129 AB - Drug resistance continues to be a major challenge in the treatment of HIV-1 infection. Virtually all currently available antiretroviral medications inhibit the viral reverse transcriptase or protease. Enfuvirtide is the first fusion inhibitor approved by the US Food and Drug Administration for use in combination with other antiretroviral agents for the treatment of HIV-1 infection in treatment-experienced patients. This paper describes the pharmacologic properties and clinical usefulness of enfuvirtide. Relevant information was identified through searches of MEDLINE (1990 to October 2003), International Pharmaceutical Abstracts (1970 to October 2003), and meeting abstracts of major HIV/AIDS conferences (1996-2003) using the search terms enfuvirtide, pentafuside, T-20, DP-178, and fusion inhibitor. In vitro, enfuvirtide exhibits activity against HIV-1 isolates that are resistant to all other classes of anti-retroviral medications. Enfuvirtide blocks the entry of HIV-1 into host cells by interfering with virus-cell fusion, making it unique among licensed antiretroviral medications. In human adults, enfuvirtide has a volume of distribution of 5.48 L, is highly bound to plasma protein (92%), has a plasma elimination half-life of 3.8 hours, and is catabolized by peptidases and proteinases in various tissues. Dose adjustment does not appear necessary on the basis of age, race, or body weight, but may be warranted in women weighing 15 cases per 100 patient-years of exposure) adverse events (AEs) in clinical trials included injection-site reactions, diarrhea, nausea, fatigue, insomnia, peripheral neuropathy, headache, vomiting, and fever. The most commonly reported (> or =2%) laboratory abnormalities (grade III or IV) were eosinophilia, anemia, and increases in amylase, lipase, triglycerides, creatine phosphokinase, alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase. In clinical trials, serious AEs leading to study discontinuation occurred in 12.9% ( 114/885 ) of patients in the enfuvirtide arm, compared with 10.7% ( 12/112 ) in the control arm ( P = NS ). The recommended dosage of enfuvirtide is 90 mg SC BID in adults and 2 mg/kg SC BID in children. Efficacy studies in children are ongoing. Although additional studies are needed, enfuvirtide appears to be a promising agent, in combination with other antiretroviral agents, for the treatment of HIV infection in treatment-experienced patients. JF - Clinical therapeutics AU - Fung, Horatio B AU - Guo, Yi AD - Critical Care Center, Veterans Affairs Medical Center, Bronx, New York 10468, USA. horatio.fung@med.va.gov Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 352 EP - 378 VL - 26 IS - 3 SN - 0149-2918, 0149-2918 KW - HIV Envelope Protein gp41 KW - 0 KW - HIV Fusion Inhibitors KW - Peptide Fragments KW - enfuvirtide KW - 19OWO1T3ZE KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Interactions KW - Drug Resistance, Viral KW - Humans KW - Clinical Trials as Topic KW - Economics, Pharmaceutical KW - Peptide Fragments -- therapeutic use KW - HIV Fusion Inhibitors -- pharmacokinetics KW - Peptide Fragments -- pharmacology KW - HIV Infections -- drug therapy KW - HIV Envelope Protein gp41 -- therapeutic use KW - HIV Fusion Inhibitors -- therapeutic use KW - HIV Envelope Protein gp41 -- pharmacology KW - Peptide Fragments -- pharmacokinetics KW - HIV Fusion Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71870535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+therapeutics&rft.atitle=Enfuvirtide%3A+a+fusion+inhibitor+for+the+treatment+of+HIV+infection.&rft.au=Fung%2C+Horatio+B%3BGuo%2C+Yi&rft.aulast=Fung&rft.aufirst=Horatio&rft.date=2004-03-01&rft.volume=26&rft.issue=3&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Clinical+therapeutics&rft.issn=01492918&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-13 N1 - Date created - 2004-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rosiglitazone and heart failure: long-term vigilance. AN - 71836009; 15094965 AB - Thiazolidinediones have become a powerful tool for lowering insulin resistance. In many short-term clinical studies, many patients taking thiazolidinediones experience significant improvement in glycemic control and lipid profiles without any adverse effects. Health care providers should be aware that, in long-term follow-up, peripheral edema and congestive heart failure may occur in patients with multiple comorbidities more than 26 weeks after starting thiazolidinediones. This article reports two patients who developed congestive heart failure 6 to 12 months after starting rosiglitazone, in combination with insulin. The patients' glycemic control improved over the first 3 to 6 months of therapy. When edema and congestive heart failure occurred later, they recovered only after medical therapy (diuretics, afterload reduction) was titrated and the rosiglitazone was withdrawn. JF - Journal of cardiovascular pharmacology and therapeutics AU - Singh, Nalini AD - Department of Endocrinology and Metabolism, Veterans Affairs Puget Sound Healthcare System, Medicine-111, 1660 South Columbian Way, Seattle, WA 98108, USA. Nalini.Singh2@med.va.gov Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 21 EP - 25 VL - 9 IS - 1 SN - 1074-2484, 1074-2484 KW - Hypoglycemic Agents KW - 0 KW - Insulin KW - Thiazolidinediones KW - rosiglitazone KW - 05V02F2KDG KW - Index Medicus KW - Edema -- chemically induced KW - Humans KW - Aged KW - Middle Aged KW - Insulin Resistance KW - Time Factors KW - Male KW - Diabetes Mellitus -- drug therapy KW - Hypoglycemic Agents -- therapeutic use KW - Thiazolidinediones -- adverse effects KW - Hypoglycemic Agents -- adverse effects KW - Heart Failure -- chemically induced KW - Insulin -- therapeutic use KW - Thiazolidinediones -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71836009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.atitle=Rosiglitazone+and+heart+failure%3A+long-term+vigilance.&rft.au=Singh%2C+Nalini&rft.aulast=Singh&rft.aufirst=Nalini&rft.date=2004-03-01&rft.volume=9&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+pharmacology+and+therapeutics&rft.issn=10742484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-07-20 N1 - Date created - 2004-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The impact of dose per cycle of etoposide and cisplatin on outcomes in patients with extensive small-cell lung cancer. AN - 71834281; 15086968 AB - Etoposide/cisplatin is the standard chemotherapy regimen used in the United States for the treatment of small-cell lung cancer (SCLC). A wide variety of dose and schedules have been employed when managing these patients. We conducted an analysis of the phase II/III trials of etoposide/cisplatin in the past 20 years to determine whether the dose and cycle of either drug affected outcomes in patients with extensive SCLC. We identified 15 phase I/II studies, which included 1419 patients. Etoposide doses per cycle ranged from 180 mg/m(2) to 510 mg/m(2) and cisplatin doses per cycle ranged from 80 mg/m2 to 280 mg/m(2). With logistic regression analysis, we found that increasing doses of etoposide resulted in increased complete response rates (P = 0.01) but had no impact on overall response rates. Cisplatin dose per cycle had no influence on complete or overall response. With linear regression analysis, we were unable to find a relationship between survival and dose per cycle of etoposide or cisplatin. Variations in the administration of this regimen had no impact on outcomes in patients with extensive SCLC. JF - Clinical lung cancer AU - Niell, Harvey B AU - Beganovic, Said AU - Richey, Sylvia AU - Wan, Jim Y AD - Veterans Administration Medical Center, University of Tennessee Cancer Institute, Memphis, USA. hniell@utmem.edu Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 299 EP - 302 VL - 5 IS - 5 SN - 1525-7304, 1525-7304 KW - Etoposide KW - 6PLQ3CP4P3 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Neoplasm Staging KW - Etoposide -- administration & dosage KW - Clinical Trials, Phase II as Topic KW - Leukopenia -- chemically induced KW - Humans KW - Treatment Outcome KW - Thrombocytopenia -- chemically induced KW - Neutropenia -- chemically induced KW - Survival Analysis KW - Cisplatin -- administration & dosage KW - Carcinoma, Small Cell -- pathology KW - Lung Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Small Cell -- drug therapy KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71834281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+lung+cancer&rft.atitle=The+impact+of+dose+per+cycle+of+etoposide+and+cisplatin+on+outcomes+in+patients+with+extensive+small-cell+lung+cancer.&rft.au=Niell%2C+Harvey+B%3BBeganovic%2C+Said%3BRichey%2C+Sylvia%3BWan%2C+Jim+Y&rft.aulast=Niell&rft.aufirst=Harvey&rft.date=2004-03-01&rft.volume=5&rft.issue=5&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Clinical+lung+cancer&rft.issn=15257304&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-18 N1 - Date created - 2004-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuropsychiatric side effects of HCV therapy and their treatment: focus on IFN alpha-induced depression. AN - 71823955; 15081102 AB - Psychiatric disorders, particularly depression, and substance-use disorders (SUDs) are common comorbidities in patients who have chronic hepatitis C virus (HCV) infection. Patients who are infected with HCV who are treated with interferon alfa (IFNalpha) are also at significant risk for IFNalpha-induced depression (incidence, ~20-30%) and other neuropsychiatric side effects that can affect treatment adherence, require dose reduction or discontinuation, and impact patient quality of life adversely. Because psychiatric illness and SUD comorbidities are so common, patients who have hepatitis C should be screened for these disorders. If these disorders are present, patients should be referred to a mental health care provider for appropriate treatment before therapy with IFNalpha is considered. Having a comanagement model of care that involves mental health care providers should help identify appropriate candidates for IFNalpha therapy. If preexisting depression responds to antidepressant treatment IFNalpha therapy can then be initiated. Patients who have other active psychiatric disorders can probably be offered IFNalpha therapy safely with appropriate monitoring and management involving a mental health care professional; however, there is a paycity of research in this area, and the few published studies have small sample sizes. If depression develops during IFNalpha therapy, most patients respond to treatment with selective serotonin-reuptake inhibitors, often allowing patients to continue receiving IFNalpha therapy. In addition to screening patients and treating those who have psychiatric disorders before IFNalpha therapy is started, early recognition of psychiatric disorders and neuropsychiatric side effects during IRNalpha therapy through continued screening and monitoring, with appropriate management, can potentially maximize HCV treatment adherence and possibly improve antiviral therapy outcomes. JF - Gastroenterology clinics of North America AU - Hauser, Peter AD - Oregon Health Science University, and Behavioral Health and Clincial Neurosciences Division, Portland VA Medical Center, 97239, USA. pater.hauser2@med.va.gov Y1 - 2004/03// PY - 2004 DA - March 2004 SP - S35 EP - S50 VL - 33 IS - 1 Suppl SN - 0889-8553, 0889-8553 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - Index Medicus KW - Humans KW - Antiviral Agents -- therapeutic use KW - Interferon-alpha -- therapeutic use KW - Interferon-alpha -- adverse effects KW - Hepatitis C -- drug therapy KW - Depression -- therapy KW - Antiviral Agents -- adverse effects KW - Depression -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71823955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology+clinics+of+North+America&rft.atitle=Neuropsychiatric+side+effects+of+HCV+therapy+and+their+treatment%3A+focus+on+IFN+alpha-induced+depression.&rft.au=Hauser%2C+Peter&rft.aulast=Hauser&rft.aufirst=Peter&rft.date=2004-03-01&rft.volume=33&rft.issue=1+Suppl&rft.spage=S35&rft.isbn=&rft.btitle=&rft.title=Gastroenterology+clinics+of+North+America&rft.issn=08898553&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-12 N1 - Date created - 2004-04-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identifying work organization targets for a work-related musculoskeletal symptom prevention program. AN - 71786084; 15055501 AB - While research linking work organization factors to work-related musculoskeletal disorders has been increasing, there is still a need to delineate specific dimensions to be targeted by intervention programs. The present cross-sectional investigation identified work organization risk factors for low back (LB) and upper extremity (UE) symptoms and determined the magnitudes of such associations. Questionnaires containing items on ergonomic, individual psychosocial, and occupational psychosocial factors were administered to a sample of workers (n = 248 U.S. Marines) in previously identified high-risk job categories for musculoskeletal disorders. Study participants were categorized into groups of either having LB symptoms only, UE symptoms only, concurrent LB and UE symptoms, or being asymptomatic on the basis of self-report. Additionally, measures of pain intensity, physical function, and mental health were obtained. Linear regression analyses adjusting for demographics, ergonomic factors, and individual psychosocial factors indicated that decision authority and experienced responsibility for work were significant correlates for pain intensity during the week. Logistic regression analyses indicated that ergonomic stressors were a risk factor for all symptomatic groups (OR = 1.02 per point increase; 95% CI: 1.0-1.1). Time pressure (OR = 1.2 per point increase; 95% CI: 1.0-1.4) was also a significant risk factor for all symptomatic groups, while cognitive processing placed workers at higher risks for concurrent LB and UE symptoms (OR = 1.2; 95% CI: 1.0-1.4). Interpersonal demands placed individuals at a lower risk for LB symptoms (OR = 0.8; 95% CI: 0.5-1.0). Findings highlight the importance of intervention approaches that address time pressure, cognitive processing factors, and interpersonal demands at work. In light of past biobehavioral studies, these results also suggest that job redesign and interventions that address a worker's workstyle when faced with increased work demands may help reduce the likelihood of musculoskeletal symptoms and/or their intensity. JF - Journal of occupational rehabilitation AU - Huang, Grant D AU - Feuerstein, Michael AD - Office of Research & Development, U.S. Department of Veterans Affairs, Washington, District of Columbia, USA. Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 13 EP - 30 VL - 14 IS - 1 SN - 1053-0487, 1053-0487 KW - Index Medicus KW - Regression Analysis KW - Human Engineering KW - Humans KW - Occupational Health -- statistics & numerical data KW - Military Personnel -- statistics & numerical data KW - Cross-Sectional Studies KW - Upper Extremity -- injuries KW - Virginia -- epidemiology KW - Risk Factors KW - Stress, Psychological KW - Adult KW - District of Columbia -- epidemiology KW - Middle Aged KW - California -- epidemiology KW - Female KW - Male KW - Musculoskeletal Diseases -- etiology KW - Workload -- psychology KW - Musculoskeletal Diseases -- prevention & control KW - Low Back Pain -- epidemiology KW - Occupational Diseases -- prevention & control KW - Low Back Pain -- prevention & control KW - Occupational Diseases -- etiology KW - Low Back Pain -- etiology KW - Occupational Diseases -- epidemiology KW - Musculoskeletal Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71786084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+rehabilitation&rft.atitle=Identifying+work+organization+targets+for+a+work-related+musculoskeletal+symptom+prevention+program.&rft.au=Huang%2C+Grant+D%3BFeuerstein%2C+Michael&rft.aulast=Huang&rft.aufirst=Grant&rft.date=2004-03-01&rft.volume=14&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+rehabilitation&rft.issn=10530487&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-13 N1 - Date created - 2004-04-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Beliefs about evidence-based practices in addiction treatment: a survey of Veterans Administration program leaders. AN - 71774173; 15050084 AB - The purpose of this study was to determine Veterans Administration addiction treatment program leaders' familiarity with evidence-based practices, understanding of and attitudes toward existing VA treatment guidelines, the extent to which specific practices should be implemented, and perceived barriers to implementation. Two hundred and twenty surveys were mailed to program leaders between November 1999 and May 2000. One hundred and seventy-four (79%) were completed, representing 135 out of 162 (83%) facilities. Program leaders saw guidelines as educational tools that improved quality of care and could be implemented into existing programs. However, they also perceived staff resistance to implementation. The most strongly cited barriers to implementation were lack of administrative support, insufficient staff time, and lack of skills or knowledge. Several treatments were seen as strongly evidentiary, but were not widely implemented, suggesting possible foci for future translation studies. JF - Journal of substance abuse treatment AU - Willenbring, Mark L AU - Kivlahan, Daniel AU - Kenny, Marie AU - Grillo, Michael AU - Hagedorn, Hildi AU - Postier, Andrea AD - Quality Enhancement Research Initiative-SUD Module, Minneapolis VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA. mark.willenbring@med.va.gov Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 79 EP - 85 VL - 26 IS - 2 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - United States KW - Attitude of Health Personnel KW - Substance Abuse Treatment Centers -- organization & administration KW - United States Department of Veterans Affairs KW - Humans KW - Adult KW - Practice Guidelines as Topic KW - Health Plan Implementation KW - Middle Aged KW - Data Collection KW - Male KW - Female KW - Evidence-Based Medicine KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71774173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Beliefs+about+evidence-based+practices+in+addiction+treatment%3A+a+survey+of+Veterans+Administration+program+leaders.&rft.au=Willenbring%2C+Mark+L%3BKivlahan%2C+Daniel%3BKenny%2C+Marie%3BGrillo%2C+Michael%3BHagedorn%2C+Hildi%3BPostier%2C+Andrea&rft.aulast=Willenbring&rft.aufirst=Mark&rft.date=2004-03-01&rft.volume=26&rft.issue=2&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-07-21 N1 - Date created - 2004-03-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Donepezil for alcohol-related dementia: a case report. AN - 71759224; 15040658 AB - A 75-year old man with a 40-year history of alcoholism was admitted to the hospital for intoxication and inability to care for himself. He had been admitted frequently in the past for detoxification and rehabilitation. The patient had no family history of Alzheimer's disease, no history of head injury, and single-photon emission computed tomography showed no typical findings of Alzheimer's disease. His cognitive function was impaired. He was treated with donepezil for alcohol-related dementia, and 3 months later, his cognitive function had improved. More research is needed to confirm donepezil's role in treating alcohol-related dementia. JF - Pharmacotherapy AU - Kim, Kye Y AU - Ke, Victoria AU - Adkins, Laurie M AD - Extended Care Psychiatry Program, Salem Veterans Affairs Medical Center, Salem, Virginia 24153, USA. kye.kim@med.va.gov Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 419 EP - 421 VL - 24 IS - 3 SN - 0277-0008, 0277-0008 KW - Indans KW - 0 KW - Piperidines KW - donepezil KW - 8SSC91326P KW - Vitamin B 12 KW - P6YC3EG204 KW - Index Medicus KW - Cognition Disorders -- diagnosis KW - Drug Administration Schedule KW - Vitamin B 12 Deficiency -- diagnosis KW - Vitamin B 12 -- therapeutic use KW - Cognition Disorders -- drug therapy KW - Humans KW - Vitamin B 12 Deficiency -- complications KW - Aged KW - Vitamin B 12 -- blood KW - Vitamin B 12 Deficiency -- drug therapy KW - Treatment Outcome KW - Vitamin B 12 -- administration & dosage KW - Injections KW - Time Factors KW - Cognition Disorders -- complications KW - Male KW - Alcohol-Related Disorders -- diagnosis KW - Indans -- therapeutic use KW - Alcohol-Related Disorders -- complications KW - Alcohol-Related Disorders -- drug therapy KW - Piperidines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71759224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Donepezil+for+alcohol-related+dementia%3A+a+case+report.&rft.au=Kim%2C+Kye+Y%3BKe%2C+Victoria%3BAdkins%2C+Laurie+M&rft.aulast=Kim&rft.aufirst=Kye&rft.date=2004-03-01&rft.volume=24&rft.issue=3&rft.spage=419&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-19 N1 - Date created - 2004-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Twelve-week outcomes from an investigation of high-dose nicotine patch therapy for heavy smokers with a past history of alcohol dependence. AN - 71742985; 15008689 AB - This study reports findings from an investigation of the efficacy of high-dose nicotine patch (NP) therapy for heavy smokers with a past history of alcohol dependence. One hundred thirty participants were randomly assigned to 42 mg or 21 mg of transdermal nicotine for 4 weeks, followed by an 8-week dose titration. Follow-up assessments were conducted at 4 and 12 weeks. Differences between dose conditions were nonsignificant, although unexpectedly, outcomes favored participants in the 21-mg NP condition. Nicotine abstinence at follow-up was related to longer length of alcohol abstinence at time of enrollment. Future research should investigate ways to improve smoking quit rates in this population, including more frequent counseling sessions and/or other pharmacotherapies. These investigations should focus primarily on smokers in early alcohol recovery. JF - Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors AU - Kalman, David AU - Kahler, Christopher W AU - Tirch, Dennis AU - Kaschub, Cynthia AU - Penk, Walter AU - Monti, Peter M AD - Department of Psychiatry, School of Medicine, Boston University, Boston, MA, USA. david.kalman@med.va.gov Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 78 EP - 82 VL - 18 IS - 1 SN - 0893-164X, 0893-164X KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Administration, Cutaneous KW - Double-Blind Method KW - Humans KW - Linear Models KW - Middle Aged KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Nicotine -- adverse effects KW - Nicotine -- administration & dosage KW - Smoking -- psychology KW - Smoking -- drug therapy KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71742985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+addictive+behaviors+%3A+journal+of+the+Society+of+Psychologists+in+Addictive+Behaviors&rft.atitle=Twelve-week+outcomes+from+an+investigation+of+high-dose+nicotine+patch+therapy+for+heavy+smokers+with+a+past+history+of+alcohol+dependence.&rft.au=Kalman%2C+David%3BKahler%2C+Christopher+W%3BTirch%2C+Dennis%3BKaschub%2C+Cynthia%3BPenk%2C+Walter%3BMonti%2C+Peter+M&rft.aulast=Kalman&rft.aufirst=David&rft.date=2004-03-01&rft.volume=18&rft.issue=1&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Psychology+of+addictive+behaviors+%3A+journal+of+the+Society+of+Psychologists+in+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-21 N1 - Date created - 2004-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical and economic comparison of epoetin alfa and darbepoetin alfa. AN - 71730398; 15025847 AB - The pharmacoeconomics of erythropoietic therapy for the treatment of anemia is receiving renewed attention due to the current availability of two agents. Epoetin alfa has been the standard of therapy for patients with renal disease and cancer-related anemia for more than a decade. Darbepoetin alfa, an alternative agent, is now approved for anemia resulting from renal disease and cancer chemotherapy. Although direct comparative trials have not been performed with these agents, information published in the last several years regarding their clinical efficacy, safety, and dosing is sufficient, in most cases, to compare costs. With the disclaimer that any efficacy comparison of competing products using published reports has certain limitations, a cost-minimization approach from a provider's perspective was conducted. To provide background for the economic evaluation, pharmacokinetic and pharmacodynamic data for these two agents are discussed. Recent clinical trials in the nephrology and oncology therapeutic areas are summarized, highlighting study designs, dosing regimens, patient entry criteria, study endpoints, and published results. Cost data, based on average wholesale prices (AWP) in 2003, are compared and calculated from available clinical data with an emphasis on efficacy. These evaluations largely conclude that epoetin alfa is the better pharmacoeconomic value of the two currently available erythropoietic agents. JF - Current medical research and opinion AU - Morreale, Anthony AU - Plowman, Brian AU - DeLattre, Melissa AU - Boggie, Dan AU - Schaefer, Monica AD - Pharmacy Services, VA San Diego Health Care System, San Diego, California 92161, USA. anthony.morreale@med.va.gov Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 381 EP - 395 VL - 20 IS - 3 SN - 0300-7995, 0300-7995 KW - Antineoplastic Agents KW - 0 KW - Hematinics KW - Recombinant Proteins KW - Erythropoietin KW - 11096-26-7 KW - Darbepoetin alfa KW - 15UQ94PT4P KW - Epoetin Alfa KW - 64FS3BFH5W KW - Index Medicus KW - Erythrocytes -- drug effects KW - Neoplasms -- complications KW - Dose-Response Relationship, Drug KW - Humans KW - Cost-Benefit Analysis KW - Treatment Outcome KW - Economics, Pharmaceutical KW - Kidney Failure, Chronic -- complications KW - Antineoplastic Agents -- adverse effects KW - Erythropoietin -- analogs & derivatives KW - Erythropoietin -- economics KW - Erythropoietin -- pharmacology KW - Hematinics -- pharmacokinetics KW - Hematinics -- economics KW - Erythropoietin -- pharmacokinetics KW - Anemia -- chemically induced KW - Anemia -- drug therapy KW - Hematinics -- pharmacology KW - Anemia -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71730398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+medical+research+and+opinion&rft.atitle=Clinical+and+economic+comparison+of+epoetin+alfa+and+darbepoetin+alfa.&rft.au=Morreale%2C+Anthony%3BPlowman%2C+Brian%3BDeLattre%2C+Melissa%3BBoggie%2C+Dan%3BSchaefer%2C+Monica&rft.aulast=Morreale&rft.aufirst=Anthony&rft.date=2004-03-01&rft.volume=20&rft.issue=3&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Current+medical+research+and+opinion&rft.issn=03007995&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-06-10 N1 - Date created - 2004-03-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Curr Med Res Opin. 2004 Sep;20(9):1461; author reply 1462-3 [15487107] Curr Med Res Opin. 2004 Sep;20(9):1459-60; author reply 1462-3 [15383195] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Asbestos and the pleura: a review. AN - 71712877; 15006974 JF - Chest AU - Cugell, David W AU - Kamp, David W AD - Feinberg School of Medicine, Division of Respiratory and Critical Care Medicine, Northwestern University and The Veterans Administration Chicago Health Care System, Lakeside Division, Chicago, IL, USA. mymble@northwestern.edu Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 1103 EP - 1117 VL - 125 IS - 3 SN - 0012-3692, 0012-3692 KW - Asbestos KW - 1332-21-4 KW - Abridged Index Medicus KW - Index Medicus KW - Pulmonary Atelectasis -- pathology KW - Lung -- diagnostic imaging KW - Pleural Effusion -- pathology KW - Fibrosis KW - Humans KW - Mesothelioma -- etiology KW - Pleura -- diagnostic imaging KW - Pleural Neoplasms -- pathology KW - Pleural Effusion -- diagnostic imaging KW - Pleura -- pathology KW - Pleural Effusion -- etiology KW - Mesothelioma -- diagnosis KW - Environmental Exposure KW - Pulmonary Atelectasis -- etiology KW - Mesothelioma -- pathology KW - Radiography KW - Pleural Neoplasms -- etiology KW - Pulmonary Atelectasis -- diagnostic imaging KW - Pleural Neoplasms -- diagnosis KW - Pleural Diseases -- pathology KW - Pleural Diseases -- etiology KW - Asbestos -- adverse effects KW - Pleural Diseases -- diagnostic imaging KW - Asbestosis -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71712877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Asbestos+and+the+pleura%3A+a+review.&rft.au=Cugell%2C+David+W%3BKamp%2C+David+W&rft.aulast=Cugell&rft.aufirst=David&rft.date=2004-03-01&rft.volume=125&rft.issue=3&rft.spage=1103&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-01 N1 - Date created - 2004-03-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Chest. 2004 Oct;126(4):1388; author reply 1388. [15486417] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sudden Illness and Biographical Flow in Narratives of Stroke Recovery AN - 60488794; 200413435 AB - The conceptual framework of biographical disruption has dominated studies into the everyday experience of chronic illness. Biographical disruption assumes that the illness presents the person with an intense crisis, regardless of other mitigating factors. However, our data suggests that the lives of people who have a particular illness that is notably marked by sudden onset are not inevitably disrupted. Extensive qualitative interviews were conducted with a sample of veteran non-Hispanic white, African American, & Puerto Rican Hispanic stroke survivors, at one month, six months, & twelve months after being discharged home from hospital. Narrative excerpts are presented to describe specific discursive resources these people use that offset the disrupting connotations of stroke. Our findings suggest a biographical flow more than a biographical disruption to specific chronic illnesses once certain social indicators such as age, other health concerns, & previous knowledge of the illness experience, are taken into account. This difference in biographical construction of the lived self has been largely ignored in the literature. Treating all survivor experiences as universal glosses over some important aspects of the survival experience, resulting in poorly designed interventions, & in turn, low outcomes for particular people. 45 References. Adapted from the source document. JF - Sociology of Health and Illness AU - Faircloth, Christopher A AU - Boylstein, Craig AU - Rittman, Maude AU - Young, Mary Ellen AU - Gubrium, Jaber AD - Rehabilitation Outcomes Research Center, North Florida-South Georgia VA Medical Center, Gainesville christopher.faircloth@med.va.gov Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 242 EP - 261 VL - 26 IS - 2 SN - 0141-9889, 0141-9889 KW - stroke KW - Veterans KW - Whites KW - Black Americans KW - Puerto Rico KW - Rehabilitation KW - Chronic Illness KW - Narratives KW - Florida KW - Puerto Rican Americans KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60488794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sociology+of+Health+and+Illness&rft.atitle=Sudden+Illness+and+Biographical+Flow+in+Narratives+of+Stroke+Recovery&rft.au=Faircloth%2C+Christopher+A%3BBoylstein%2C+Craig%3BRittman%2C+Maude%3BYoung%2C+Mary+Ellen%3BGubrium%2C+Jaber&rft.aulast=Faircloth&rft.aufirst=Christopher&rft.date=2004-03-01&rft.volume=26&rft.issue=2&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Sociology+of+Health+and+Illness&rft.issn=01419889&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Number of references - 45 N1 - Last updated - 2016-09-28 N1 - CODEN - SHILDJ N1 - SubjectsTermNotLitGenreText - Chronic Illness; Narratives; Rehabilitation; Whites; Puerto Rican Americans; Black Americans; Puerto Rico; Florida; Veterans ER - TY - JOUR T1 - Mechanism of Sequential Swallowing during Straw Drinking in Healthy Young and Older Adults AN - 85574415; 200509102 AB - Recent research has revealed differences between isolated & sequential swallowing in healthy young adults; however, the influence of normal aging on sequential swallowing has not been studied. Thus, the purpose of this investigation was to examine the effects of normal aging on deglutition during sequential straw drinking. Videofluoroscopic samples of two 10-s straw drinking trials were obtained for 20 healthy young men (age 29 +/- 3 years) & 18 healthy older men (age 69 +/- 7 years). Hyolaryngeal complex (HLC) movement patterns, leading edge of the bolus location at swallow onset, & occurrences of airway invasion were determined. Two HLC patterns were identified: (1) HLC lowering with the epiglottis returned to upright between swallows & (2) partially maintained HLC elevation with the epiglottis inverted between swallows. The bolus was frequently in the hypopharynx at swallow onset. Strong associations were identified between age & HLC pattern, age & leading edge of the bolus location, & HLC pattern & leading edge location. Laryngeal penetration was uncommon overall; however, it occurred more frequently in the older adults than in the young adults. A significant relation was identified between age & the average Penetration-Aspiration Scale score. Laryngeal penetration was associated with both HLC movement patterns & hypopharyngeal bolus location, particularly in older adults. Results indicate that subtle age-related differences are evident in healthy young & older adults with sequential straw drinking. These data suggest that specific inherent swallowing patterns may increase the risk of laryngeal penetration with normal aging. Adapted from the source document JF - Journal of Speech, Language, and Hearing Research AU - Daniels, Stephanie K AU - Corey, David M AU - Hadskey, Leslie D AU - Legendre, Calli AU - Priestly, Daniel H AU - Rosenbek, John C AU - Foundas, Anne L AD - Veterans Affairs Medical Center, New Orleans, LA stephanie.daniels@med.va.gov Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 33 EP - 45 VL - 47 IS - 1 SN - 1092-4388, 1092-4388 KW - swallowing KW - Elderly (21350) KW - Age Differences (01150) KW - Vocal Tract (94900) KW - Adults (00600) KW - article KW - 6210: hearing and speech physiology; hearing and speech physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85574415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=Mechanism+of+Sequential+Swallowing+during+Straw+Drinking+in+Healthy+Young+and+Older+Adults&rft.au=Daniels%2C+Stephanie+K%3BCorey%2C+David+M%3BHadskey%2C+Leslie+D%3BLegendre%2C+Calli%3BPriestly%2C+Daniel+H%3BRosenbek%2C+John+C%3BFoundas%2C+Anne+L&rft.aulast=Daniels&rft.aufirst=Stephanie&rft.date=2004-02-01&rft.volume=47&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2005-08-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Vocal Tract (94900); Elderly (21350); Age Differences (01150); Adults (00600) ER - TY - JOUR T1 - Development of quality of care indicators for Parkinson's disease. AN - 85373611; pmid-14978668 AB - Parkinson's disease (PD) is a major cause of disability. To date, there have been no large-scale efforts to measure the quality of PD care because of a lack of quality indicators for conducting an explicit review of PD care processes. We present a set of quality indicators for PD care. Based on a structured review of the medical literature, 79 potential indicators were drafted. Through a two-round modified Delphi process, an expert panel of seven movement disorders specialists rated each indicator on criteria of validity, feasibility, impact on outcomes, room for improvement, and overall utility. Seventy-one quality indicators met validity and feasibility thresholds. Applying thresholds for impact on outcomes, room for improvement, and overall utility, a subset of 29 indicators was identified, spanning dopaminergic therapy, assessment of functional status, assessment and treatment of depression, coordination of care, and medication use. Multivariable analysis showed that overall utility ratings were driven by validity and impact on outcomes (P < 0.01). An expert panel can reach consensus on a set of highly rated quality indicators for PD care, which can be used to assess quality of PD care and guide the design of quality improvement projects. JF - Movement disorders : official journal of the Movement Disorder Society AU - Cheng, Eric M AU - Siderowf, Andrew AU - Swarztrauber, Kari AU - Eisa, Mahmood AU - Lee, Martin AU - Vickrey, Barbara G AD - Parkinson's Disease Research, Education Clinical Center (PADRECC), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA. eric.cheng@med.va.gov Y1 - 2004/02// PY - 2004 DA - Feb 2004 SP - 136 EP - 150 VL - 19 IS - 2 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Activities of Daily Living KW - *Critical Pathways: statistics & numerical data KW - Expert Testimony KW - Feasibility Studies KW - Humans KW - Outcome and Process Assessment (Health Care): standards KW - *Parkinson Disease: therapy KW - *Quality Indicators, Health Care: standards KW - Quality of Life KW - Reproducibility of Results KW - Specialization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85373611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Development+of+quality+of+care+indicators+for+Parkinson%27s+disease.&rft.au=Cheng%2C+Eric+M%3BSiderowf%2C+Andrew%3BSwarztrauber%2C+Kari%3BEisa%2C+Mahmood%3BLee%2C+Martin%3BVickrey%2C+Barbara+G&rft.aulast=Cheng&rft.aufirst=Eric&rft.date=2004-02-01&rft.volume=19&rft.issue=2&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The cognitive benefits of galantamine are sustained for at least 36 months: a long-term extension trial. AN - 80162897; 14967774 AB - Alzheimer disease (AD) causes progressive cognitive and functional decline over years. Although cholinesterase inhibitors have demonstrated efficacy in studies lasting 3 to 6 months, little is known about long-term therapy. To report the long-term cognitive effects of galantamine hydrobromide given continuously for 36 months in AD patients. Subjects were 194 US patients with mild to moderate AD who had been randomized to continuous galantamine therapy in either of 2 double-blind placebo-controlled trials. Subjects subsequently received open-label continuous galantamine therapy for up to 36 months. Effects on cognition were analyzed as change from study enrollment baseline in scores on the Alzheimer's Disease Assessment Scale-11-item cognitive subscale. Cognitive decline in galantamine-treated subjects was compared with that in a clinically similar historical control sample of AD patients who had received placebo for 12 months and with the mathematically predicted decline of untreated patients over 36 months. The rate of cognitive decline of patients who completed the entire 36-month trial (n = 119) was compared with that of patients who withdrew for any reason during the long-term open-label extension (n = 75). An inverted responder analysis was also performed in 36-month completers. Patients treated continuously with galantamine for 36 months increased a mean +/- SE of 10.2 +/- 0.9 points on the Alzheimer's Disease Assessment Scale-11-item cognitive subscale-a substantially smaller cognitive decline (approximately 50%) than that predicted for untreated patients. Patients discontinuing galantamine therapy before 36 months had declined at a similar rate before discontinuation as those completing 36 months of treatment. Almost 80% of patients who received galantamine continuously for up to 36 months seemed to demonstrate cognitive benefits compared with those predicted for untreated patients. Cognitive decline over 36 months of continuous galantamine treatment was substantially less than the predicted cognitive decline of untreated patients with mild to moderate dementia. Thus, the cognitive benefits of galantamine seemed to be sustained for at least 36 months. These findings suggest that galantamine slows the clinical progression of AD. JF - Archives of neurology AU - Raskind, Murray A AU - Peskind, Elaine R AU - Truyen, Luc AU - Kershaw, Paul AU - Damaraju, ChandrasekharRao Venkata AD - Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle 98108, USA. murray.raskind@med.va.gov Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 252 EP - 256 VL - 61 IS - 2 SN - 0003-9942, 0003-9942 KW - Cholinesterase Inhibitors KW - 0 KW - Galantamine KW - 0D3Q044KCA KW - Abridged Index Medicus KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Double-Blind Method KW - Aged, 80 and over KW - Humans KW - Disease Progression KW - Aged KW - Long-Term Care KW - Neuropsychological Tests KW - Male KW - Female KW - Electrocardiography -- drug effects KW - Galantamine -- adverse effects KW - Cholinesterase Inhibitors -- adverse effects KW - Cognition -- drug effects KW - Cholinesterase Inhibitors -- therapeutic use KW - Alzheimer Disease -- drug therapy KW - Alzheimer Disease -- psychology KW - Galantamine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80162897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+neurology&rft.atitle=The+cognitive+benefits+of+galantamine+are+sustained+for+at+least+36+months%3A+a+long-term+extension+trial.&rft.au=Raskind%2C+Murray+A%3BPeskind%2C+Elaine+R%3BTruyen%2C+Luc%3BKershaw%2C+Paul%3BDamaraju%2C+ChandrasekharRao+Venkata&rft.aulast=Raskind&rft.aufirst=Murray&rft.date=2004-02-01&rft.volume=61&rft.issue=2&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Archives+of+neurology&rft.issn=00039942&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-08 N1 - Date created - 2004-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacogenomic-guided rational therapeutic drug monitoring: conceptual framework and application platforms for atypical antipsychotics. AN - 80160018; 14965233 AB - Atypical antipsychotic agents such as aripiprazole, clozapine, olanzapine, quetiapine and ziprasidone offer many advantages over conventional neuroleptics. These agents reduce negative symptoms of schizophrenia, are effective in treatment refractory cases, and have a markedly lower incidence of extrapyramidal symptoms and tardive dyskinesia. However, there is considerable patient-to-patient variability in therapeutic dose requirements of atypical antipsychotics and the propensity for side effects. Hence, the initial excitement since the introduction of atypical antipsychotics in late 1980s is now shifting towards a focus on individualization of pharmacotherapy and elucidation of the mechanistic basis of interindividual variability in drug response with use of pharmacokinetic and pharmacodynamic biomarkers. Pharmacogenomics, introduced in late 1990s, is the study of variability in drug response using information from the entire genome of a given individual patient. Both pharmacogenomics and conventional therapeutic drug monitoring (TDM) share the similar goal of improving pharmacotherapy through better explanation of individual variability in drug response. Hence, pharmacogenomic biomarkers offer a unique opportunity to complement and expand the scope of traditional TDM in clinical psychopharmacology. Importantly, pharmacogenomics enables the investigation of factors distal to drug exposure in the plasma compartment (e.g. drug targets at the biophase), thereby providing a more complete portrayal of sources of variability in psychotropic drug response. We discuss (1). the definitions for biomarkers and surrogate endpoints in the context of pharmacogenomics, (2). genetic variations in isozyme-specific atypical antipsychotic metabolism in vivo, (3). selected examples of pharmacogenomic variability in pertinent drug targets and, (4). the anticipated roadmap from implementation of pharmacogenomics to changes in healthcare and therapeutic policy. In addition, a conceptual framework that outlines the theoretical advantages of pharmacogenomics-guided TDM is presented using recent clinical applications as precedence. JF - Current medicinal chemistry AU - Albers, Lawrence J AU - Ozdemir, Vural AD - Department of Psychiatry, Long Beach VA Healthcare System, University of California Irvine, USA. larry.albers@med.va.gov Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 297 EP - 312 VL - 11 IS - 3 SN - 0929-8673, 0929-8673 KW - Antipsychotic Agents KW - 0 KW - Biomarkers KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Clozapine KW - J60AR2IKIC KW - Index Medicus KW - Drug Delivery Systems KW - Drug Interactions KW - Clozapine -- pharmacokinetics KW - Clozapine -- therapeutic use KW - Humans KW - Clinical Trials as Topic KW - Cytochrome P-450 Enzyme System -- metabolism KW - Clozapine -- adverse effects KW - Pharmacogenetics KW - Antipsychotic Agents -- therapeutic use KW - Antipsychotic Agents -- pharmacokinetics KW - Drug Monitoring KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80160018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+medicinal+chemistry&rft.atitle=Pharmacogenomic-guided+rational+therapeutic+drug+monitoring%3A+conceptual+framework+and+application+platforms+for+atypical+antipsychotics.&rft.au=Albers%2C+Lawrence+J%3BOzdemir%2C+Vural&rft.aulast=Albers&rft.aufirst=Lawrence&rft.date=2004-02-01&rft.volume=11&rft.issue=3&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Current+medicinal+chemistry&rft.issn=09298673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-20 N1 - Date created - 2004-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Do clozapine and risperidone affect social competence and problem solving? AN - 80140831; 14754789 AB - The purpose of this investigation was to evaluate the effects of clozapine and risperidone on social skill and problem solving in patients with schizophrenia. The Wisconsin Card Sorting Test and the Maryland Assessment of Social Competence were administered at baseline, week 17, and week 29 of a multisite clinical trial. Despite evidence of clinical improvement with both medications, there was virtually no medication effect on either social competence or problem solving. These findings underscore the circumscribed nature of symptomatic improvement in the broader spectrum of clinical outcomes and suggest that new-generation medications may not be expected to produce substantial changes in social role functioning or social problem-solving capacity in the community. The generalizability of the findings should be viewed cautiously because of the low power of this trial, and replication is warranted. JF - The American journal of psychiatry AU - Bellack, Alan S AU - Schooler, Nina R AU - Marder, Stephen R AU - Kane, John M AU - Brown, Clayton H AU - Yang, Ye AD - Mental Health Research, Education and Clinical Center, VA Maryland Health Care System, Baltimore 21201, USA. alan.bellack@med.va.gov Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 364 EP - 367 VL - 161 IS - 2 SN - 0002-953X, 0002-953X KW - Clozapine KW - J60AR2IKIC KW - Risperidone KW - L6UH7ZF8HC KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Double-Blind Method KW - Humans KW - Adult KW - Neuropsychological Tests KW - Male KW - Female KW - Cognition Disorders -- diagnosis KW - Social Behavior KW - Schizophrenia -- drug therapy KW - Cognition Disorders -- chemically induced KW - Risperidone -- adverse effects KW - Clozapine -- adverse effects KW - Problem Solving -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80140831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Do+clozapine+and+risperidone+affect+social+competence+and+problem+solving%3F&rft.au=Bellack%2C+Alan+S%3BSchooler%2C+Nina+R%3BMarder%2C+Stephen+R%3BKane%2C+John+M%3BBrown%2C+Clayton+H%3BYang%2C+Ye&rft.aulast=Bellack&rft.aufirst=Alan&rft.date=2004-02-01&rft.volume=161&rft.issue=2&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-01 N1 - Date created - 2004-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer. AN - 80138189; 14762775 AB - 5-Fluorouracil improves mortality in stage III colorectal cancer patients. In vitro studies suggest that microsatellite instability influences cell survival after 5-fluorouracil treatment. We investigated the survival influence of 5-fluorouracil in patients with microsatellite instability-high tumors. We collected data and tumors on 204 consecutive stage II and III colorectal cancer patients from registries at the University of California and Veterans Administration hospitals in San Diego, California, from 1982 to 1999. Archival DNA was extracted, and microsatellite instability was assessed by National Cancer Institute-recommended markers. Cox proportional hazard modeling was used to determine survival associations for microsatellite instability and 5-fluorouracil treatment status. We identified 36 microsatellite instability-high (17.6%) and 168 non-microsatellite instability-high tumors (82.4%). Microsatellite instability-high tumors were significantly associated with proximal colon location, presence of mucin, and surrounding lymphoid reaction. Univariate and multivariate analyses showed no survival difference between microsatellite instability-high and non-microsatellite instability-high groups (hazard ratio, 1.04; P = 0.88). Dichotomized by use of 5-fluorouracil, there was increased risk of death in patients who received no adjuvant chemotherapy (hazard ratio, 2.02; P = 0.02). However, the benefit of 5-fluorouracil was different between microsatellite instability-high and non-microsatellite instability-high groups. Patients with non-microsatellite instability-high tumors who received 5-fluorouracil had better survival compared with patients who were not treated (P < 0.05). Conversely, patients with microsatellite instability-high tumors who were treated with 5-fluorouracil had no survival difference compared with patients without treatment (P = 0.52). There is improved survival in patients with non-microsatellite instability-high tumors after 5-fluorouracil-based chemotherapy that does not extend to patients with microsatellite instability-high tumors. The microsatellite instability status of a patient's colorectal cancer may indicate differences in 5-fluorouracil-based chemosensitivity; this is consistent with in vitro studies. JF - Gastroenterology AU - Carethers, John M AU - Smith, E Julieta AU - Behling, Cynthia A AU - Nguyen, Lanchinh AU - Tajima, Akihiro AU - Doctolero, Ryan T AU - Cabrera, Betty L AU - Goel, Ajay AU - Arnold, Christian A AU - Miyai, Katsumi AU - Boland, C Richard AD - Department of Gastroenterology and Cancer Center, University of California, and Veterans Administration Research Service, San Diego, 92161, USA. jcarethers@ucsd.edu Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 394 EP - 401 VL - 126 IS - 2 SN - 0016-5085, 0016-5085 KW - Antimetabolites, Antineoplastic KW - 0 KW - Genetic Markers KW - Fluorouracil KW - U3P01618RT KW - Abridged Index Medicus KW - Index Medicus KW - Registries KW - Neoplasm Staging KW - Humans KW - Cohort Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Survival Analysis KW - Proportional Hazards Models KW - Fluorouracil -- therapeutic use KW - Microsatellite Repeats -- genetics KW - Colorectal Neoplasms -- pathology KW - Colorectal Neoplasms -- genetics KW - Colorectal Neoplasms -- drug therapy KW - Antimetabolites, Antineoplastic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80138189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Use+of+5-fluorouracil+and+survival+in+patients+with+microsatellite-unstable+colorectal+cancer.&rft.au=Carethers%2C+John+M%3BSmith%2C+E+Julieta%3BBehling%2C+Cynthia+A%3BNguyen%2C+Lanchinh%3BTajima%2C+Akihiro%3BDoctolero%2C+Ryan+T%3BCabrera%2C+Betty+L%3BGoel%2C+Ajay%3BArnold%2C+Christian+A%3BMiyai%2C+Katsumi%3BBoland%2C+C+Richard&rft.aulast=Carethers&rft.aufirst=John&rft.date=2004-02-01&rft.volume=126&rft.issue=2&rft.spage=394&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-26 N1 - Date created - 2004-02-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Gastroenterology. 2004 Aug;127(2):688-9; author reply 689-90 [15300610] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Radiation safety precautions for sentinel lymph node procedures. AN - 80113180; 14744068 AB - Radiation safety professionals need guidelines for controlling occupational radiation doses and handling generated contaminated tissues from sentinel lymph node procedures involving 99mTc. Many healthcare facilities do not have formal controls in place, or they adopt policies that may be too restrictive or impractical. During accreditation inspections at healthcare facilities, agencies such as the College of American Pathology and the Joint Commission on the Accreditation of Healthcare Organizations occasionally raise questions about these issues. Inspectors expect to find formal policies to ensure these procedures are performed safely. The objective of this article is to review the basic radiation safety controls needed during sentinel lymph node procedures and to propose guidelines that may be used to control occupational radiation doses and handling of SLN contaminated tissues. JF - Health physics AU - Michel, René AU - Hofer, Curtis AD - VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA. rene.michel@med.va.gov Y1 - 2004/02// PY - 2004 DA - February 2004 SP - S35 EP - S37 VL - 86 IS - 2 Suppl SN - 0017-9078, 0017-9078 KW - Radiopharmaceuticals KW - 0 KW - Index Medicus KW - Radiation Dosage KW - Occupational Exposure -- prevention & control KW - Maximum Allowable Concentration KW - Risk Factors KW - Humans KW - Safety KW - Practice Guidelines as Topic KW - Decontamination KW - Intraoperative Care -- methods KW - Radiometry -- methods KW - Occupational Exposure -- analysis KW - Radionuclide Imaging KW - Radiation Protection -- methods KW - Specimen Handling -- adverse effects KW - Lymph Nodes -- diagnostic imaging KW - Radiation Injuries -- prevention & control KW - Lymph Nodes -- pathology KW - Specimen Handling -- methods KW - Radiopharmaceuticals -- adverse effects KW - Radiation Protection -- instrumentation KW - Sentinel Lymph Node Biopsy -- methods KW - Radiation Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80113180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Radiation+safety+precautions+for+sentinel+lymph+node+procedures.&rft.au=Michel%2C+Ren%C3%A9%3BHofer%2C+Curtis&rft.aulast=Michel&rft.aufirst=Ren%C3%A9&rft.date=2004-02-01&rft.volume=86&rft.issue=2+Suppl&rft.spage=S35&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-25 N1 - Date created - 2004-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Social reinforcement of substance abuse treatment aftercare participation: Impact on outcome. AN - 80111734; 14732421 AB - Although adherence to aftercare therapy in substance abuse treatment is associated with improved outcome, little research has explored the effects of adherence interventions on outcome. We compared 20 graduates of our 28-day intensive treatment program who received a standard aftercare orientation with 20 graduates who received this intervention plus social reinforcement of aftercare group therapy attendance. The social reinforcement group showed less alcohol use than the standard care group at a 6-month follow-up assessment as measured by the Addiction Severity Index (ASI), but not less drug use. Additionally, compared to standard care, the social reinforcement participants were more likely to be abstinent at the 6-month follow up (76% vs. 40%). The groups did not differ on hospital readmission rates over a 12-month follow-up period. Additionally, the social reinforcement group showed better long-term aftercare attendance compared to the standard care group. JF - Addictive behaviors AU - Lash, Steven J AU - Burden, Jennifer L AU - Monteleone, Brian R AU - Lehmann, Lauren P AD - Substance Abuse Residential Rehabilitation Treatment Program (116A4), Veterans Affairs Medical Center, Salem, VA 24153, USA. Steven.Lash@med.va.gov Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 337 EP - 342 VL - 29 IS - 2 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Alcoholism -- rehabilitation KW - Psychiatric Status Rating Scales KW - Patient Compliance KW - Humans KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Reinforcement, Social KW - Aftercare -- methods KW - Substance-Related Disorders -- rehabilitation KW - Aftercare -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80111734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Social+reinforcement+of+substance+abuse+treatment+aftercare+participation%3A+Impact+on+outcome.&rft.au=Lash%2C+Steven+J%3BBurden%2C+Jennifer+L%3BMonteleone%2C+Brian+R%3BLehmann%2C+Lauren+P&rft.aulast=Lash&rft.aufirst=Steven&rft.date=2004-02-01&rft.volume=29&rft.issue=2&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-06 N1 - Date created - 2004-01-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of topiramate on glucocorticoid receptor mediated action. AN - 80110354; 14666121 AB - This study examined the effects of topiramate (TPM) on glucocorticoid receptors (GRs) in mononuclear leukocytes of nine men and four women with chronic and recurring post-traumatic stress disorder (PTSD) and a group of comparison subjects (nine men, four women). A measure of 60 ml of blood was withdrawn by venipuncture at 0800 and mononuclear leukocytes were isolated. The cells were incubated with a series of concentrations of dexamethasone (DEX) without or with 50 micromol/l of TPM to evaluate the effects of DEX to inhibit lysozyme activity and the effect of TPM on it. ANCOVA compared the IC(50) for lysozyme inhibition under conditions of DEX only and TPM+DEX. TPM affected lysozyme IC(50) in the direction of increasing the sensitivity of the receptor in the sample as a whole. This effect was more pronounced in the mononuclear leukocytes from participants in the PTSD group, particularly in cells from subjects whose pretreatment lysozyme IC(50) was relatively higher (eg, reflecting decreased glucococorticoid receptor responsiveness), compared to the rest of the sample. In conclusion, further investigation of the actions of TPM on GR and other neuroendocrine systems may prove useful in understanding some of the other established clinical effects of this agent. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Yehuda, Rachel AU - Yang, Ren-Kui AU - Golier, Julia A AU - Tischler, Lisa AU - Liong, Betty AU - Decker, Kelly AD - The Traumatic Stress Studies Program, Department of Psychiatry, Mount Sinai School of Medicine and the Bronx Veterans Affairs Medical Center, Bronx, NY, USA. rachel.yehuda@med.va.gov Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 433 EP - 439 VL - 29 IS - 2 SN - 0893-133X, 0893-133X KW - Anticonvulsants KW - 0 KW - Glucocorticoids KW - Receptors, Glucocorticoid KW - topiramate KW - 0H73WJJ391 KW - Fructose KW - 30237-26-4 KW - Dexamethasone KW - 7S5I7G3JQL KW - Muramidase KW - EC 3.2.1.17 KW - Index Medicus KW - Drug Interactions KW - Dexamethasone -- pharmacology KW - Humans KW - Aged KW - Muramidase -- metabolism KW - Stress Disorders, Post-Traumatic -- blood KW - Glucocorticoids -- pharmacology KW - Binding Sites KW - Demography KW - Adult KW - Surveys and Questionnaires KW - Case-Control Studies KW - Middle Aged KW - Inhibitory Concentration 50 KW - Stress Disorders, Post-Traumatic -- drug therapy KW - Female KW - Male KW - Anticonvulsants -- pharmacology KW - Receptors, Glucocorticoid -- drug effects KW - Fructose -- analogs & derivatives KW - Leukocytes, Mononuclear -- metabolism KW - Fructose -- therapeutic use KW - Leukocytes, Mononuclear -- drug effects KW - Anticonvulsants -- therapeutic use KW - Receptors, Glucocorticoid -- physiology KW - Fructose -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80110354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Effect+of+topiramate+on+glucocorticoid+receptor+mediated+action.&rft.au=Yehuda%2C+Rachel%3BYang%2C+Ren-Kui%3BGolier%2C+Julia+A%3BTischler%2C+Lisa%3BLiong%2C+Betty%3BDecker%2C+Kelly&rft.aulast=Yehuda&rft.aufirst=Rachel&rft.date=2004-02-01&rft.volume=29&rft.issue=2&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-27 N1 - Date created - 2004-01-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationship of childhood trauma to age of first suicide attempt and number of attempts in substance dependent patients. AN - 80100674; 14725593 AB - To examine whether childhood trauma effect the age of first attempting suicide and the number of attempts. One thousand twelve hundred and eighty substance dependent patients were interviewed about whether or not they had ever attempted suicide, the age of first attempt and the number of attempts. Patients completed the Childhood Trauma Questionnaire - 34 item version. Five hundred and thirty-eight patients (42%) had attempted suicide. Significantly more of the patients who had attempted suicide were female. Patients who had made three or more attempts had significantly higher childhood trauma scores than patients who had made two attempts, who had higher scores than patients who had made one attempt, who had higher scores than patients who had never attempted. Patients who first attempted suicide before the age of 20 years had significantly higher childhood trauma scores than patients who first attempted after 20 years of age. Childhood trauma may be a determinant of the age of onset of suicidal behavior and of the number of suicide attempts. JF - Acta psychiatrica Scandinavica AU - Roy, A AD - Department of Veterans Affairs, New Jersey Healthcare System, East Orange, NJ 07108, USA.. alec.roy@med.va.gov Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 121 EP - 125 VL - 109 IS - 2 SN - 0001-690X, 0001-690X KW - Index Medicus KW - Analysis of Variance KW - New Jersey -- epidemiology KW - Age of Onset KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Child KW - Time Factors KW - Male KW - Female KW - Child Abuse -- psychology KW - Suicide, Attempted -- statistics & numerical data KW - Suicide, Attempted -- psychology KW - Child Abuse -- statistics & numerical data KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80100674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+psychiatrica+Scandinavica&rft.atitle=Relationship+of+childhood+trauma+to+age+of+first+suicide+attempt+and+number+of+attempts+in+substance+dependent+patients.&rft.au=Roy%2C+A&rft.aulast=Roy&rft.aufirst=A&rft.date=2004-02-01&rft.volume=109&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Acta+psychiatrica+Scandinavica&rft.issn=0001690X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-06-17 N1 - Date created - 2004-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Experimental avoidance as a mediator of the effects of adolescent sexual victimization on negative adult outcomes. AN - 72000430; 15179750 AB - The study examined experiential avoidance as a mediator between sexual victimization and negative adult outcomes. Baron and Kenny's (1986) regression analyses were performed on a sample of 304 undergraduate women to assess direct and indirect effects of sexual victimization on depressive, psychological distress, and alcohol abuse symptoms. Experiential avoidance accounted for statistically significant, but modest effects of victimization on depressive and distress symptoms. Child sexual abuse was not directly associated with experiential avoidance or negative outcomes, but increased vulnerability for adolescent sexual victimization. Adolescent sexual victimization contributed to increased experiential avoidance, which was associated with greater negative outcomes. These results uniquely contribute to the existing literature linking experiential avoidance to psychological problems. JF - Violence and victims AU - Polusny, Melissa A AU - Rosenthal, M Zachary AU - Aban, Inmaculada AU - Follette, Victoria M AD - Minneapolis Veterans Affairs Medical Center, University of Minnesota Medical School, USA. melissa.polusny@med.va.gov Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 109 EP - 120 VL - 19 IS - 1 SN - 0886-6708, 0886-6708 KW - Index Medicus KW - Students -- psychology KW - Regression Analysis KW - Alcoholism -- etiology KW - Models, Psychological KW - Anxiety -- psychology KW - Humans KW - Psychometrics KW - Alcoholism -- psychology KW - Stress, Psychological -- etiology KW - Self Concept KW - Depression -- etiology KW - Depression -- psychology KW - Adult KW - Midwestern United States KW - Universities KW - Adolescent KW - Anxiety -- etiology KW - Female KW - Child Abuse, Sexual -- psychology KW - Adaptation, Psychological KW - Crime Victims -- psychology KW - Avoidance Learning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72000430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Violence+and+victims&rft.atitle=Experimental+avoidance+as+a+mediator+of+the+effects+of+adolescent+sexual+victimization+on+negative+adult+outcomes.&rft.au=Polusny%2C+Melissa+A%3BRosenthal%2C+M+Zachary%3BAban%2C+Inmaculada%3BFollette%2C+Victoria+M&rft.aulast=Polusny&rft.aufirst=Melissa&rft.date=2004-02-01&rft.volume=19&rft.issue=1&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Violence+and+victims&rft.issn=08866708&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-13 N1 - Date created - 2004-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - The Veterans Aging Cohort Study: observational studies of alcohol use, abuse, and outcomes among human immunodeficiency virus-infected veterans. AN - 71877594; 15112939 AB - This article represents the proceedings of a symposium at the 2003 annual meeting of the Research Society on Alcoholism in Fort Lauderdale, FL. The organizers/chairs were Joseph Conigliaro and Amy Justice. The presentations were (1) Introduction, by Joseph Conigliaro and Tamra Madenwald; (2) Alcohol and HIV/AIDS: the importance of integrative and translational research, by Kendall Bryant; (3) Alcohol use and abuse among patients with HIV infection, by Joseph Conigliaro and Stephan Maisto; (4) Severity of comorbid alcohol use/abuse in HIV infection, by Amy Justice and Jeffrey Samet; (5) Estimating the impact of alcohol use on long-term HIV outcomes, by Scott Braithwaite and Amy Justice; (6) Homelessness, drug & alcohol use among HIV+ veterans, by Adam Gordon and Robert Cook; and (7) Hepatitis C & alcohol in the VACS 3 study, by Shawn Fultz and Kevin Kraemer. The symposium concluded with a discussion led and facilitated by Diedra Roach. JF - Alcoholism, clinical and experimental research AU - Conigliaro, Joseph AU - Madenwald, Tamra AU - Bryant, Kendall AU - Braithwaite, Scott AU - Gordon, Adam AU - Fultz, Shawn L AU - Maisto, Stephen AU - Samet, Jeffrey AU - Kraemer, Kevin AU - Cook, Robert AU - Day, Nancy AU - Roach, Diedra AU - Richey, Susan AU - Justice, Amy Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 313 EP - 321 VL - 28 IS - 2 KW - Index Medicus KW - United States KW - Animals KW - Humans KW - Cohort Studies KW - Treatment Outcome KW - Longitudinal Studies KW - Societies, Medical KW - Alcohol Drinking -- drug therapy KW - Veterans -- statistics & numerical data KW - HIV Infections -- complications KW - Alcoholism -- epidemiology KW - HIV Infections -- drug therapy KW - Aging KW - Alcohol Drinking -- epidemiology KW - HIV Infections -- epidemiology KW - Alcoholism -- complications KW - Alcoholism -- drug therapy KW - Military Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71877594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=The+Veterans+Aging+Cohort+Study%3A+observational+studies+of+alcohol+use%2C+abuse%2C+and+outcomes+among+human+immunodeficiency+virus-infected+veterans.&rft.au=Conigliaro%2C+Joseph%3BMadenwald%2C+Tamra%3BBryant%2C+Kendall%3BBraithwaite%2C+Scott%3BGordon%2C+Adam%3BFultz%2C+Shawn+L%3BMaisto%2C+Stephen%3BSamet%2C+Jeffrey%3BKraemer%2C+Kevin%3BCook%2C+Robert%3BDay%2C+Nancy%3BRoach%2C+Diedra%3BRichey%2C+Susan%3BJustice%2C+Amy&rft.aulast=Conigliaro&rft.aufirst=Joseph&rft.date=2004-02-01&rft.volume=28&rft.issue=2&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-17 N1 - Date created - 2004-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of intravenous amino acid administration with Y-90 DOTA-Phe1-Tyr3-Octreotide (SMT487[OctreoTher) treatment. AN - 71810258; 15068609 AB - Y-90-DOTA-Phe1-Tyr3-Octreotide (90Y-SMT 487, OctreoTher) has shown potential for effectively treating patients with neuroendocrine tumors. The dose-limiting organ for this agent is the kidney. The purpose of this work is to assess the effectiveness of a commercially available amino acid solution on reducing renal uptake of 90Y-SMT 487 and determine the safety profile of this solution. Subjects with In-111 pentetreotide positive tumors and normal creatinine levels were treated with 3 cycles of 90Y-SMT 487, 120 mCi/cycle, at 6-9 week intervals. During each treatment two liters of an amino acid solution containing arginine and lysine (Aminosyn II 7%, Abbott Laboratories, Abbott Park, IL) were infused IV over 4 hours. Adverse events were recorded. To assess the effect of Aminosyn II on renal uptake of 90Y-SMT 487, a subgroup of subjects underwent bremsstrahlung imaging 24 hours following infusion. Kidney to liver (K/L) count density ratios were generated from the baseline In-111 pentetreotide images (performed without amino acid infusion) and the 90Y bremsstrahlung images. Follow-up creatinine levels were obtained. Thirty-seven subjects received a total of 89 90Y-SMT 487 treatments. The number of amino-acid infusions associated with one or more episodes of emesis was 53 (62%). During 13 (15%) of these infusions, the Aminosyn II rate had to be reduced because of severe nausea and vomiting. Symptomatic flushing occurred during 16 (18%) of the infusions. One subject experienced a near syncopal event shortly after completing the infusion. Creatinine levels remained normal in 34 of 36 subjects during a mean follow-up period of 9.8 months. Fourteen subjects underwent bremsstrahlung imaging following infusion of 90Y-SMT 487. Kidney uptake appeared to decrease with administration of the amino acid solution in 13 of 14 subjects. For the 28 individual kidneys, the mean percent decrease in the Kidney/Liver uptake ratio with the amino acid solution was found to be 32%. We conclude that 2 L of Aminosyn II 7% infused over 4 hours appears to notably reduce renal uptake of 90Y-SMT 487. Aminosyn is generally well tolerated, particularly at lower infusion rates with occasional moderate to severe nausea and vomiting at higher rates. JF - Cancer biotherapy & radiopharmaceuticals AU - Bushnell, David AU - Menda, Yusuf AU - O'Dorisio, Thomas AU - Madsen, Mark AU - Miller, Sara AU - Carlisle, Thomas AU - Squires, Shayne AU - Kahn, Daniel AU - Walkner, Wayne AU - Connolly, Mary AU - O'Dorisio, Sue AU - Karwal, Mark AU - Ponto, James AU - Bouterfa, Hakim AD - Iowa City Veterans Administration Hospital, Diagnostic Imaging and Radioisotope Therapy Service, Iowa City, IA 52240, USA. davie-bushnell@uiowa.edu Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 35 EP - 41 VL - 19 IS - 1 SN - 1084-9785, 1084-9785 KW - Amino Acids KW - 0 KW - Radiopharmaceuticals KW - Yttrium Radioisotopes KW - Arginine KW - 94ZLA3W45F KW - Lysine KW - K3Z4F929H6 KW - Octreotide KW - RWM8CCW8GP KW - Edotreotide KW - U194AS08HZ KW - Index Medicus KW - Radiopharmaceuticals -- pharmacokinetics KW - Lysine -- pharmacology KW - Radiopharmaceuticals -- administration & dosage KW - Pancreatic Neoplasms -- metabolism KW - Lung Neoplasms -- radiotherapy KW - Infusions, Intravenous KW - Humans KW - Aged KW - Radiopharmaceuticals -- adverse effects KW - Arginine -- administration & dosage KW - Arginine -- pharmacology KW - Radiopharmaceuticals -- therapeutic use KW - Pancreatic Neoplasms -- radiotherapy KW - Meningioma -- metabolism KW - Adult KW - Middle Aged KW - Meningioma -- radiotherapy KW - Lysine -- administration & dosage KW - Carcinoid Tumor -- metabolism KW - Carcinoid Tumor -- radiotherapy KW - Male KW - Female KW - Lung Neoplasms -- metabolism KW - Amino Acids -- administration & dosage KW - Yttrium Radioisotopes -- therapeutic use KW - Yttrium Radioisotopes -- administration & dosage KW - Kidney -- metabolism KW - Octreotide -- analogs & derivatives KW - Yttrium Radioisotopes -- pharmacokinetics KW - Octreotide -- therapeutic use KW - Octreotide -- adverse effects KW - Kidney -- drug effects KW - Yttrium Radioisotopes -- adverse effects KW - Octreotide -- administration & dosage KW - Amino Acids -- pharmacology KW - Octreotide -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71810258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biotherapy+%26+radiopharmaceuticals&rft.atitle=Effects+of+intravenous+amino+acid+administration+with+Y-90+DOTA-Phe1-Tyr3-Octreotide+%28SMT487%5BOctreoTher%29+treatment.&rft.au=Bushnell%2C+David%3BMenda%2C+Yusuf%3BO%27Dorisio%2C+Thomas%3BMadsen%2C+Mark%3BMiller%2C+Sara%3BCarlisle%2C+Thomas%3BSquires%2C+Shayne%3BKahn%2C+Daniel%3BWalkner%2C+Wayne%3BConnolly%2C+Mary%3BO%27Dorisio%2C+Sue%3BKarwal%2C+Mark%3BPonto%2C+James%3BBouterfa%2C+Hakim&rft.aulast=Bushnell&rft.aufirst=David&rft.date=2004-02-01&rft.volume=19&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Cancer+biotherapy+%26+radiopharmaceuticals&rft.issn=10849785&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-10-26 N1 - Date created - 2004-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Initiating HIV therapy. Timing is critical, controversial. AN - 71701523; 15000057 AB - Currently available antiretroviral drug regimens are able to suppress HIV replication and allow CD4 recovery in the vast majority of patients with HIV infection. The challenge is to match each patient to the regimen that is most likely to durably suppress HIV replication enough to prevent resistance selection without causing treatment-limiting toxicities. It is also critical, but difficult, to know when to begin treatment relative to CD4 cell count and plasma viral load. In this article, Dr Volberding addresses the central questions surrounding antiretroviral treatment initiation and reviews some available treatment options. JF - Postgraduate medicine AU - Volberding, Paul A AD - University of California, San Francisco, School of Medicine, UCSF-Gladstone Institute of Virology and Immunology Center for AIDS Research, San Francisco Veterans Affairs Medical Center, USA. paul.volberding@med.va.gov Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 15 EP - 8, 21, 24-6 VL - 115 IS - 2 SN - 0032-5481, 0032-5481 KW - Anti-Retroviral Agents KW - 0 KW - Protease Inhibitors KW - Abridged Index Medicus KW - Index Medicus KW - Viral Load KW - Protease Inhibitors -- therapeutic use KW - Drug Therapy, Combination KW - Protease Inhibitors -- adverse effects KW - Risk Factors KW - Humans KW - CD4 Lymphocyte Count KW - Time Factors KW - HIV Infections -- immunology KW - HIV Infections -- drug therapy KW - Anti-Retroviral Agents -- adverse effects KW - Anti-Retroviral Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71701523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Postgraduate+medicine&rft.atitle=Initiating+HIV+therapy.+Timing+is+critical%2C+controversial.&rft.au=Volberding%2C+Paul+A&rft.aulast=Volberding&rft.aufirst=Paul&rft.date=2004-02-01&rft.volume=115&rft.issue=2&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Postgraduate+medicine&rft.issn=00325481&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-23 N1 - Date created - 2004-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vogt-Koyanagi-Harada syndrome and ulcerative colitis. AN - 71674810; 14982267 AB - The Vogt-Koyanagi-Harada (VKH) syndrome is an uncommon disorder characterized by uveitis and neurologic and cutaneous abnormalities, including tinnitus, vertigo, headache, meningoencephalitis, vitiligo, alopecia, and poliosis. The VKH syndrome has been reported to occur in association with other autoimmune disorders. We report a case of a patient with severe ulcerative colitis who developed VKH syndrome. We postulate that the patient's history of a traumatic brain injury might have been responsible for an abnormal "immunologic milieu" and the occurrence of ulcerative colitis, VKH syndrome, and severe reactive arthritis. JF - Southern medical journal AU - Federman, Daniel G AU - Kravetz, Jeffrey D AU - Ruser, Christopher B AU - Judson, Peter H AU - Kirsner, Robert S AD - Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. daniel.federman@med.va.gov Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 169 EP - 171 VL - 97 IS - 2 SN - 0038-4348, 0038-4348 KW - Glucocorticoids KW - 0 KW - Prednisone KW - VB0R961HZT KW - Abridged Index Medicus KW - Index Medicus KW - Prednisone -- adverse effects KW - Prednisone -- therapeutic use KW - Humans KW - Adult KW - Glucocorticoids -- adverse effects KW - Glucocorticoids -- therapeutic use KW - Male KW - Alopecia -- chemically induced KW - Colitis, Ulcerative -- complications KW - Uveomeningoencephalitic Syndrome -- physiopathology KW - Uveomeningoencephalitic Syndrome -- complications KW - Uveomeningoencephalitic Syndrome -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71674810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Vogt-Koyanagi-Harada+syndrome+and+ulcerative+colitis.&rft.au=Federman%2C+Daniel+G%3BKravetz%2C+Jeffrey+D%3BRuser%2C+Christopher+B%3BJudson%2C+Peter+H%3BKirsner%2C+Robert+S&rft.aulast=Federman&rft.aufirst=Daniel&rft.date=2004-02-01&rft.volume=97&rft.issue=2&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-09 N1 - Date created - 2004-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-term opiate effects on amphetamine-induced dopamine release in the nucleus accumbens core and conditioned place preference AN - 19267442; 5827855 AB - Withdrawal following chronic exposure to opiates or other drugs of abuse, administered as frequent doses, or a chronic infusion can cause reductions in mesolimbic dopamine (DA) transmission. However, mesolimbic da transmission can be enhanced by opiates or psychostimulants administered intermittently as a single daily injection. Both enhanced and attenuated responsiveness of the mesolimbic da system may have important implications for substance abuse disorders. Previous studies have shown that procedures that use electrical stimulation or drug treatments to augment neurotransmitter release are more effective for demonstrating declines in mesolimbic da transmission that persist for extended periods following opiate withdrawal. The present study evaluated the effects of pretreatment with noncontingent morphine on amphetamine-induced da release in the nucleus accumbens core and conditioned place preference (CPP). Morphine pretreatment was administered as a constant infusion, which was gradually increased to a dose of 50 mg/kg/day over a 1-week period in Wistar rats. At 10 days after cessation of morphine pretreatment, baseline dialysate da levels in the nucleus accumbens core were unchanged, but amphetamine-induced increases in da were attenuated by greater than 50% in morphine-pretreated animals. Morphine pretreatment did not modify locomotor activity during conditioning sessions, expressed as absolute values or change in activity counts between saline and morphine injections. Place preference, conditioned by two morphine pairings at 10 and 11 days after the onset of opiate withdrawal, was enhanced by opiate pretreatment between 12 and 33 days after the onset of withdrawal. In conclusion, morphine pretreatment delivered as a constant infusion can have pronounced and long-lasting effects on da release and CPP, which may have important implications for drug-seeking behavior and treatment of substance abuse disorders. JF - Pharmacology Biochemistry and Behavior AU - He, S AU - Li, N AU - Grasing, K AD - Substance Abuse Research Laboratory, Research Service, Kansas City Veterans Affairs Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA, kenneth.grasing@med.va.gov Y1 - 2004/02// PY - 2004 DA - Feb 2004 SP - 327 EP - 335 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 77 IS - 2 SN - 0091-3057, 0091-3057 KW - rats KW - conditioned place preference KW - Animal Behavior Abstracts; Toxicology Abstracts KW - Nucleus accumbens KW - Morphine KW - Dopamine KW - Opiates KW - Amphetamine KW - Place preference conditioning KW - X 24180:Social poisons & drug abuse KW - Y 25817:Mammals (excluding primates) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19267442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+Biochemistry+and+Behavior&rft.atitle=Long-term+opiate+effects+on+amphetamine-induced+dopamine+release+in+the+nucleus+accumbens+core+and+conditioned+place+preference&rft.au=He%2C+S%3BLi%2C+N%3BGrasing%2C+K&rft.aulast=He&rft.aufirst=S&rft.date=2004-02-01&rft.volume=77&rft.issue=2&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Pharmacology+Biochemistry+and+Behavior&rft.issn=00913057&rft_id=info:doi/10.1016%2Fj.pbb.2003.11.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Place preference conditioning; Morphine; Opiates; Nucleus accumbens; Dopamine; Amphetamine DO - http://dx.doi.org/10.1016/j.pbb.2003.11.014 ER - TY - JOUR T1 - A Paradox-based data collection and management system for multi-center randomized clinical trials AN - 19267137; 5826889 AB - We have developed a Paradox-based data collection and management system for large-scale multi-site randomized clinical trials. The system runs under Windows operating system and integrates Symantec pcAnywhere32 telecommunications software for data transmission and remote control sessions, PKZIP utility for the compression/decompression of transmitted data, and Stat/Transfer for exporting the centralized Paradox database for analyses. We initially developed this system for VA Cooperative Study #399 'The Effect of Antiarrhythmic Therapy in Maintaining Stability of Sinus Rhythm in Atrial Fibrillation', which collects over 1000 variables on 706 patients at 20 sites. Patient intake for this 5-year study began in March of 1998. We have also developed an enhanced version of this system, which is being used in the NIH-funded 'Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT)' that collects over 1200 variables on 1588 patients at 13 sites. Patient intake for this 4-year study began in October of 2000. JF - Computer Methods and Programs in Biomedicine AU - Abdellatif, M AU - Reda, D J AD - Hines VA Cooperative Studies Program Coordinating Center (151K), P.O. Box 5000, 5th Ave. and Roosevelt Rd. Bldg. 1, Rm. B240, Hines, IL 60141-5000, USA, abdellat@research.hines.med.va.gov Y1 - 2004/02// PY - 2004 DA - Feb 2004 SP - 145 EP - 164 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo@elsevier.com], [URL:http://www.elsevier.nl] VL - 73 IS - 2 SN - 0169-2607, 0169-2607 KW - man KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Databases KW - Data collections KW - Clinical trials KW - Information systems KW - W4 140:Bioinformatics & Computers in Health & Medicine KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19267137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computer+Methods+and+Programs+in+Biomedicine&rft.atitle=A+Paradox-based+data+collection+and+management+system+for+multi-center+randomized+clinical+trials&rft.au=Abdellatif%2C+M%3BReda%2C+D+J&rft.aulast=Abdellatif&rft.aufirst=M&rft.date=2004-02-01&rft.volume=73&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Computer+Methods+and+Programs+in+Biomedicine&rft.issn=01692607&rft_id=info:doi/10.1016%2FS0169-2607%2803%2900019-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Clinical trials; Data collections; Information systems; Databases DO - http://dx.doi.org/10.1016/S0169-2607(03)00019-1 ER - TY - JOUR T1 - Anthrax Vaccination and Self-reported Symptoms, Functional Status, and Medical Conditions in the National Health Survey of Gulf War Era Veterans and Their Families AN - 17930850; 5868757 AB - To evaluate the health status of Gulf War veterans who reported receipt of anthrax vaccination and a small group of Gulf War veterans for whom documentation of anthrax vaccination exists. Among the 11,441 Gulf War veterans who completed a health survey, 4601 reported receiving the anthrax vaccine during the war; 2979 veterans reported not receiving it; 3861 were uncertain. Also, 352 of these respondents were documented by the Department of Defense as having received anthrax vaccination. We compared the medical history of these groups of veterans using multivariate analyses. Finally, we analyzed perception of exposure and its relation to reporting bias. There were statistically significant differences in prevalence for almost all outcomes studied between those who reported having received anthrax vaccination and those who did not so report. However, when we compared the veterans for whom vaccination records exist to the group who self-reported that they had not received the vaccine, the significant differences in prevalence for almost all of the outcomes disappeared. The extent of a reporting bias should be carefully considered when one evaluates the health consequences of anthrax vaccination based on self-reported data. JF - Annals of Epidemiology AU - Mahan, C M AU - Kang, H K AU - Dalager, NA AU - Heller, J M AD - Environmental Epidemiology Service, Department of Veterans Affairs, 810 Vermont Avenue, NW, Washington, DC 20420, USA, han.kang@hq.med.va.gov Y1 - 2004/02// PY - 2004 DA - Feb 2004 SP - 81 EP - 88 VL - 14 IS - 2 SN - 1047-2797, 1047-2797 KW - Gulf War veterans KW - anthrax KW - vaccination KW - Health & Safety Science Abstracts KW - Military KW - Occupational exposure KW - Side effects KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17930850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Anthrax+Vaccination+and+Self-reported+Symptoms%2C+Functional+Status%2C+and+Medical+Conditions+in+the+National+Health+Survey+of+Gulf+War+Era+Veterans+and+Their+Families&rft.au=Mahan%2C+C+M%3BKang%2C+H+K%3BDalager%2C+NA%3BHeller%2C+J+M&rft.aulast=Mahan&rft.aufirst=C&rft.date=2004-02-01&rft.volume=14&rft.issue=2&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2FS1047-2797%2803%2900124-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Side effects; Military; Occupational exposure DO - http://dx.doi.org/10.1016/S1047-2797(03)00124-8 ER - TY - JOUR T1 - Three Dimensional Virtual Reality Model of the Normal Female Pelvic Floor AN - 17675781; 5960607 AB - The anatomy of the pelvic floor is complex and difficult to visualize from conventional two-dimensional anatomy pictures. The goal of this project was to establish the methods necessary to develop a static three-dimensional virtual reality model of the normal female pelvic floor from high-resolution magnetic resonance imaging (MRI) scans. An asymptomatic nulliparous 23-year-old female with no urinary incontinence symptoms underwent a high-resolution pelvic floor MRI scan. Selected pelvic floor structures were manually segmented: bladder, urethra, vagina, uterus, cervix, levator ani, obturator externus, obturator internus, and pubic bone. With high-resolution scans, accurate segmentation of the structures was possible. The completed models were displayed on an ImmersaDesk Virtual Reality system and three clinicians verified their accuracy. Stereovision glasses were used to enhance the model while a receiver tracked head position. Three-dimensional virtual reality models of the female pelvic floor can enhance our understanding of anatomy and physiology of this complex part of the body. They can be used as tools for both research and teaching, facilitating improved treatment of pelvic floor pathologies. JF - Annals of Biomedical Engineering AU - Parikh, M AU - Rasmussen, M AU - Brubaker, L AU - Salomon, C AU - Sakamoto, K AU - Evenhouse, R AU - Ai, Z AU - Damaser AD - Research Service, Hines VA Hospital, Hines, IL, USA, margot.damaser@med.va.gov Y1 - 2004/02// PY - 2004 DA - Feb 2004 SP - 292 EP - 296 VL - 32 IS - 2 SN - 0090-6964, 0090-6964 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - W4 150:Medical Imaging KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17675781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Biomedical+Engineering&rft.atitle=Three+Dimensional+Virtual+Reality+Model+of+the+Normal+Female+Pelvic+Floor&rft.au=Parikh%2C+M%3BRasmussen%2C+M%3BBrubaker%2C+L%3BSalomon%2C+C%3BSakamoto%2C+K%3BEvenhouse%2C+R%3BAi%2C+Z%3BDamaser&rft.aulast=Parikh&rft.aufirst=M&rft.date=2004-02-01&rft.volume=32&rft.issue=2&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Annals+of+Biomedical+Engineering&rft.issn=00906964&rft_id=info:doi/10.1023%2FB%3AABME.0000012749.79488.d6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1023/B:ABME.0000012749.79488.d6 ER - TY - JOUR T1 - Treatment needs associated with pain in substance use disorder patients: implications for concurrent treatment. AN - 80072002; 14687956 AB - Although pain problems are prevalent in substance use disorder (SUD) patients, the special treatment needs of SUD patients with pain have not been investigated. This study examines the problems and behaviors associated with reported pain among veterans treated at eight opioid substitution treatment clinics. Patients reporting pain had more severe medical and psychiatric problems and greater health care utilization. Pain was associated with an increased propensity for misuse of substances with analgesic effects, suggesting that ongoing pain contributes to an altered and more severe pattern of drug-seeking behavior. Patients without pain rarely abused sedatives or opioid medication, indicating that misuse of these substances is unique to co-morbid pain and SUD patients. Patients reporting pain did not differ from patients without pain in use of heroin, alcohol, cocaine or in injection practices, demonstrating that they are truly SUD patients in need of SUD treatment. Pain complicates the treatment of SUD and should be addressed as an important co-morbidity during treatment. JF - Drug and alcohol dependence AU - Trafton, Jodie A AU - Oliva, Elizabeth M AU - Horst, Doyanne A AU - Minkel, Jared D AU - Humphreys, Keith AD - Center for Health Care Evaluation, VA Palo Alto Health Care System and Stanford University School of Medicine, Menlo Park, CA 94025, USA. jodie.trafton@med.va.gov Y1 - 2004/01/07/ PY - 2004 DA - 2004 Jan 07 SP - 23 EP - 31 VL - 73 IS - 1 SN - 0376-8716, 0376-8716 KW - Analgesics, Opioid KW - 0 KW - Hypnotics and Sedatives KW - Narcotics KW - Street Drugs KW - Methadyl Acetate KW - L59OC40KWJ KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - United States KW - Analysis of Variance KW - Pain Measurement -- statistics & numerical data KW - Humans KW - Methadyl Acetate -- administration & dosage KW - Narcotics -- administration & dosage KW - Methadone -- administration & dosage KW - Comorbidity KW - Cross-Sectional Studies KW - Adult KW - Health Services -- utilization KW - Chronic Disease KW - Middle Aged KW - Statistics as Topic KW - Utilization Review KW - Female KW - Male KW - Pain -- drug therapy KW - Health Services Needs and Demand -- statistics & numerical data KW - Opioid-Related Disorders -- psychology KW - Pain -- psychology KW - Veterans -- psychology KW - Opioid-Related Disorders -- rehabilitation KW - Pain -- epidemiology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Opioid-Related Disorders -- epidemiology KW - Veterans -- statistics & numerical data KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80072002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Treatment+needs+associated+with+pain+in+substance+use+disorder+patients%3A+implications+for+concurrent+treatment.&rft.au=Trafton%2C+Jodie+A%3BOliva%2C+Elizabeth+M%3BHorst%2C+Doyanne+A%3BMinkel%2C+Jared+D%3BHumphreys%2C+Keith&rft.aulast=Trafton&rft.aufirst=Jodie&rft.date=2004-01-07&rft.volume=73&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-26 N1 - Date created - 2003-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Heterotrimeric G protein subunits are located on rat liver endosomes. AN - 71909306; 14711382 AB - Rat liver endosomes contain activated insulin receptors and downstream signal transduction molecules. We undertook these studies to determine whether endosomes also contain heterotrimeric G proteins that may be involved in signal transduction from G protein-coupled receptors. By Western blotting Gsalpha, Gialpha1,2, Gialpha3 and Gbeta were enriched in both canalicular (CM) and basolateral (BLM) membranes but also readily detectable on three types of purified rat liver endosomes in the order recycling receptor compartment (RRC) > compartment for uncoupling of receptor and ligand (CURL) > multivesicular bodies (MVB) >> purified secondary lysosomes. Western blotting with antibodies to Na, K-ATPase and to other proteins associated with plasma membranes and intracellular organelles indicated this was not due to contamination of endosome preparations by CM or BLM. Adenylate cyclase (AC) was also identified on purified CM, BLM, RRC, CURL and MVB. Percoll gradient fractionation of liver postnuclear supernatants demonstrated co-occurrence of endosomes and heterotrimeric G protein subunits in fractions with little plasma membrane markers. By confocal microscopy, punctate staining for Gsalpha, Gialpha3 and Gbeta corresponded to punctate areas of endocytosed Texas red-dextran in hepatocytes from control and cholera toxin-treated livers. We conclude that heterotrimeric G protein subunits as well as AC likely traffic into hepatocytes on endosome membranes, possibly generating downstream signals spatially separate from signalling generated at the plasma membrane, analogous to the role(s) of internalized insulin receptors. JF - BMC physiology AU - Van Dyke, Rebecca W AD - Dept of Internal Medicine, University of Michigan School of Medicine and Veterans Administration Hospital, Ann Arbor, MI 48105, USA. wynne@umich.edu Y1 - 2004/01/07/ PY - 2004 DA - 2004 Jan 07 SP - 1 VL - 4 KW - Receptors, G-Protein-Coupled KW - 0 KW - Cholera Toxin KW - 9012-63-9 KW - Heterotrimeric GTP-Binding Proteins KW - EC 3.6.5.1 KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Index Medicus KW - Microscopy, Confocal KW - Animals KW - Lysosomes -- chemistry KW - Cholera Toxin -- pharmacology KW - Receptors, G-Protein-Coupled -- physiology KW - Microscopy, Fluorescence KW - Rats KW - Endocytosis KW - Blotting, Western KW - Rats, Sprague-Dawley KW - Adenylyl Cyclases -- analysis KW - Lysosomes -- ultrastructure KW - Signal Transduction KW - Male KW - Hepatocytes -- chemistry KW - Hepatocytes -- drug effects KW - Hepatocytes -- ultrastructure KW - Endosomes -- chemistry KW - Heterotrimeric GTP-Binding Proteins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71909306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+physiology&rft.atitle=Heterotrimeric+G+protein+subunits+are+located+on+rat+liver+endosomes.&rft.au=Van+Dyke%2C+Rebecca+W&rft.aulast=Van+Dyke&rft.aufirst=Rebecca&rft.date=2004-01-07&rft.volume=4&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=BMC+physiology&rft.issn=1472-6793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-07-13 N1 - Date created - 2004-05-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cell Sci. 1998 Apr;111 ( Pt 8):1137-45 [9512509] Electrophoresis. 1997 Dec;18(14):2548-57 [9527484] Am J Physiol. 1998 Jun;274(6 Pt 1):G1151-9 [9696716] J Biol Chem. 1998 Aug 21;273(34):22007-13 [9705342] Hepatology. 1999 Nov;30(5):1115-20 [10534329] Chem Senses. 2000 Jun;25(3):313-22 [10866989] Mol Cell Biol Res Commun. 1999 May;1(2):132-9 [10356362] Electrophoresis. 2000 Oct;21(16):3386-95 [11079559] Endocrinology. 2000 Nov;141(11):4041-9 [11089534] FEBS Lett. 1998 Dec 11;441(1):34-8 [9877160] Hepatology. 1999 Feb;29(2):483-93 [9918926] Trends Pharmacol Sci. 1999 Feb;20(2):66-73 [10101967] Brain Res. 1999 May 1;826(2):253-69 [10224303] Kidney Int. 1999 Jun;55(6):2376-82 [10354285] Gastroenterology. 1999 Jul;117(1):89-98 [10381914] Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10146-51 [10468577] Hepatology. 2000 Dec;32(6):1357-69 [11093743] Gastroenterology. 2000 Dec;119(6):1692-707 [11113091] Pharmacol Rev. 2001 Mar;53(1):1-24 [11171937] J Biol Chem. 2001 Nov 9;276(45):42063-9 [11533056] Endocrinology. 2001 Dec;142(12):5069-75 [11713199] Science. 2001 Nov 30;294(5548):1939-42 [11729322] Nat Cell Biol. 2002 Feb;4(2):E33-5 [11835054] Mol Biol Cell. 2002 Oct;13(10):3400-15 [12388745] Nat Rev Mol Cell Biol. 2002 Dec;3(12):893-905 [12461556] J Lipid Res. 2003 Apr;44(4):655-67 [12562849] J Cell Biol. 1984 Mar;98(3):991-1000 [6699096] Proc Natl Acad Sci U S A. 1987 Oct;84(19):6785-9 [3477810] Biochem J. 1989 Aug 1;261(3):905-12 [2508624] FASEB J. 1990 Apr 1;4(6):1598-605 [2156741] J Biol Chem. 1991 Jan 25;266(3):1396-402 [1671034] J Cell Sci. 1990 Aug;96 ( Pt 4):691-703 [2178165] J Biol Chem. 1992 Apr 25;267(12):8213-21 [1314820] Am J Physiol. 1993 Oct;265(4 Pt 1):C901-17 [8238315] Am J Physiol. 1993 Oct;265(4 Pt 1):G686-98 [8238352] Endocrinology. 1994 Jan;134(1):233-44 [8275939] Am J Physiol. 1994 Jan;266(1 Pt 1):C81-94 [8304433] J Cell Sci Suppl. 1993;17:33-9 [8144703] Metabolism. 1995 Jun;44(6):771-8 [7783662] J Biol Chem. 1995 Jul 14;270(28):16895-902 [7622506] FEBS Lett. 1995 Aug 1;369(1):84-8 [7641891] Biochem Biophys Res Commun. 1996 May 15;222(2):312-6 [8670202] J Cell Biol. 1996 Jun;133(5):1027-40 [8655576] Hepatology. 1996 Jul;24(1):226-32 [8707267] J Biol Chem. 1996 Oct 4;271(40):24967-75 [8798777] J Cell Biochem. 1996 Sep 1;62(3):334-41 [8872605] Physiol Rev. 1997 Jul;77(3):759-803 [9234965] J Biol Chem. 1998 Jan 9;273(2):685-8 [9422717] Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5057-60 [9560227] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dilated intercellular spaces and shunt permeability in nonerosive acid-damaged esophageal epithelium. AN - 85370605; pmid-14687135 AB - It has recently been established that patients with nonerosive reflux disease have on biopsy within esophageal epithelium a lesion known as dilated intercellular spaces (DIS).To further explore the nature and implications of this lesion, in vitro models of nonerosive acid and acid-pepsin damage were created in Ussing chamber-mounted rabbit esophageal epithelium. Using these models circuit analysis and permeability studies were carried out, the latter using dextran of varying size and human epidermal growth factor (EGF).Luminal HCl, pH 1.1, or HCl, pH 2.0 + pepsin, 1 mg/ml, for 30 min significantly reduced transepithelial electrical resistance (RT) but produced no gross erosions or histologic evidence of cell necrosis. Transmission electron microscopy, however, documented the presence of DIS. Circuit analysis on healthy esophageal epithelium showed that shunt resistance (RS) was much lower than apical membrane, basolateral membrane and transcellular resistances (Ra, Rb, and Rcell, respectively) and approached that of RT. Further, circuit analysis on acid and acid-pepsin damaged tissues showed that the declines in RT resulted from declines in RS. Moreover, the declines in RT (and so RS) were associated with a linear increase in permeability to 4 kD dextrans as well as an increase in permeability to 6 kD EGF and dextrans as large as 20 kD.In nonerosive acid-damaged esophageal epithelium DIS develop in association with and as a marker of reduced transepithelial resistance and increased shunt permeability. This change in shunt permeability upon acid or acid-pepsin exposure is substantial, permitting dextran molecules as large as 20 kD (33 A) to diffuse across the epithelium. Also, this shunt leak enables luminal EGF at 6 kD to diffuse across the acid-damaged epithelium and by so doing enables it to access its receptors on epithelial basal cells. We hypothesize that the shunt leak of EGF may in part account for the development of a reparative phenomenon on esophageal biopsy in patients with nonerosive reflux disease known as basal cell hyperplasia. JF - The American journal of gastroenterology AU - Tobey, N A AU - Hosseini, S S AU - Argote, C M AU - Dobrucali, A M AU - Awayda, M S AU - Orlando, R C AD - Department of Medicine, Tulane University School of Medicine, Veterans Administration Medical Center, New Orleans, Louisiana 70112, USA. Y1 - 2004/01// PY - 2004 DA - Jan 2004 SP - 13 EP - 22 VL - 99 IS - 1 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - Dextrans: pharmacokinetics KW - Electric Conductivity KW - Epidermal Growth Factor: pharmacokinetics KW - Epithelium: metabolism KW - Epithelium: ultrasonography KW - *Esophagitis, Peptic: pathology KW - Esophagitis, Peptic: physiopathology KW - Esophagus: metabolism KW - *Esophagus: ultrasonography KW - *Extracellular Space: ultrasonography KW - Male KW - Microscopy, Electron KW - Permeability KW - Rabbits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85370605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Dilated+intercellular+spaces+and+shunt+permeability+in+nonerosive+acid-damaged+esophageal+epithelium.&rft.au=Tobey%2C+N+A%3BHosseini%2C+S+S%3BArgote%2C+C+M%3BDobrucali%2C+A+M%3BAwayda%2C+M+S%3BOrlando%2C+R+C&rft.aulast=Tobey&rft.aufirst=N&rft.date=2004-01-01&rft.volume=99&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Macrophage migration inhibitory factor is upregulated in an endotoxin-induced model of bladder inflammation in rats. AN - 80187403; 14980085 AB - Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine found in epithelial cells as preformed stores, such that MIF release can activate innate immune responses. Our identification of MIF stores in the urothelium suggests that MIF may function in the bladder's initial response to infectious stimuli, such as lipopolysaccharide (LPS). To test this hypothesis, we observed changes in MIF, cyclooxygenase-2 (COX-2) and c-fos in the bladder, L6-S1 spinal cord, dorsal root ganglion (DRG), and major pelvic ganglion (MPG) and MIF changes in the prostate following intravesical LPS. Intravesical LPS induced bladder edema and leukocyte infiltration, as well as increased MIF protein and mRNA in the bladder and lumbosacral spinal cord. Expression of immediate-early gene c-fos, a transcription factor used as a marker of neuronal activation, increased in the L6-S1 spinal cord and L6-S1 DRG of rats that received LPS. We conclude that significant increases in bladder MIF expression and protein in response to intravesical LPS may represent part of this organ's initial innate immune response. In addition, MIF upregulation may represent a neural response to visceral inflammation. Finally, changes in prostate MIF content after intravesical LPS suggest that MIF may be involved in viscerovisceral interactions associated with chronic pelvic pain syndromes. JF - Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research AU - Meyer-Siegler, Katherine L AU - Ordorica, Raul C AU - Vera, Pedro L AD - Bay Pines VA Medical Center, Research & Development Service (151), and University of South Florida, Department of Surgery, Division of Urology, Tampa, FL, USA. Katherine.Siegel@med.va.gov Y1 - 2004/01// PY - 2004 DA - January 2004 SP - 55 EP - 63 VL - 24 IS - 1 SN - 1079-9907, 1079-9907 KW - Lipopolysaccharides KW - 0 KW - Macrophage Migration-Inhibitory Factors KW - Proto-Oncogene Proteins c-fos KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Prostaglandin-Endoperoxide Synthases KW - Ptgs2 protein, rat KW - Index Medicus KW - Urinary Bladder -- pathology KW - Urinary Bladder -- metabolism KW - Animals KW - Peripheral Nervous System -- pathology KW - Peripheral Nervous System -- metabolism KW - Proto-Oncogene Proteins c-fos -- metabolism KW - Spinal Cord -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Prostaglandin-Endoperoxide Synthases -- metabolism KW - Spinal Cord -- pathology KW - Up-Regulation KW - Male KW - Macrophage Migration-Inhibitory Factors -- metabolism KW - Cystitis -- metabolism KW - Lipopolysaccharides -- toxicity KW - Cystitis -- pathology KW - Cystitis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80187403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+interferon+%26+cytokine+research+%3A+the+official+journal+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.atitle=Macrophage+migration+inhibitory+factor+is+upregulated+in+an+endotoxin-induced+model+of+bladder+inflammation+in+rats.&rft.au=Meyer-Siegler%2C+Katherine+L%3BOrdorica%2C+Raul+C%3BVera%2C+Pedro+L&rft.aulast=Meyer-Siegler&rft.aufirst=Katherine&rft.date=2004-01-01&rft.volume=24&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Journal+of+interferon+%26+cytokine+research+%3A+the+official+journal+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.issn=10799907&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-25 N1 - Date created - 2004-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparative testing of 5 nicotine systems: initial use and preferences. AN - 80171251; 14977161 AB - To test initial reactions to 5 nicotine treatments (NRTs: 2 and 4 mg gum, inhaler, nasal spray, tablet) in a crossover study (n=41). Subjects used each medication on arising (1/2 day) and resumed smoking each afternoon. Subjects rated (individually) and ranked (comparatively) treatments on use, reinforcement, withdrawal, craving, and preferences. Overall preferences: inhaler (49%), 4 mg gum (24%), 2 mg gum (10%), 2 mg tablet (10%), nasal spray (7%). Overall results were consistent with ratings and rankings of individual characteristics of drugs. Subjects had varied reactions to NRTs that may affect initiation of cessation. JF - American journal of health behavior AU - Schneider, Nina G AU - Olmstead, Richard E AU - Nides, Mitchell AU - Mody, Freny Vaghaiwalla AU - Otte-Colquette, Pamela AU - Doan, Kim AU - Patel, Shilpan AD - Nicotine Dependence Research Unit, Greater Los Angeles Veterans Administration, West Los Angeles, CA 90073, USA. ngs@ucla.edu PY - 2004 SP - 72 EP - 86 VL - 28 IS - 1 SN - 1087-3244, 1087-3244 KW - Chewing Gum KW - 0 KW - Tablets KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Substance Withdrawal Syndrome KW - Humans KW - Surveys and Questionnaires KW - Cross-Over Studies KW - Male KW - Female KW - Drug Administration Routes KW - Nicotine -- therapeutic use KW - Smoking Cessation -- psychology KW - Tobacco Use Disorder -- drug therapy KW - Smoking Cessation -- methods KW - Nicotine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80171251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health+behavior&rft.atitle=Comparative+testing+of+5+nicotine+systems%3A+initial+use+and+preferences.&rft.au=Schneider%2C+Nina+G%3BOlmstead%2C+Richard+E%3BNides%2C+Mitchell%3BMody%2C+Freny+Vaghaiwalla%3BOtte-Colquette%2C+Pamela%3BDoan%2C+Kim%3BPatel%2C+Shilpan&rft.aulast=Schneider&rft.aufirst=Nina&rft.date=2004-01-01&rft.volume=28&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health+behavior&rft.issn=10873244&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-05 N1 - Date created - 2004-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of comorbid physical illnesses among veterans with PTSD and veterans with alcohol dependence. AN - 80075893; 14699207 AB - Posttraumatic stress disorder (PTSD) is associated with high rates of medical service use and with self-reported poor health. Male veterans admitted to a rehabilitation unit for PTSD (N=55) or alcohol dependence (N=38) were evaluated for comorbid psychiatric and medical conditions and health risk factors. Patients with PTSD were more likely to have osteoarthritis, diabetes, heart disease, comorbid depression, obesity, and elevated lipid levels. These findings suggest that there may be a relationship between specific medical conditions, possibly mediated by behavioral risk factors, among the aging population of veterans with PTSD. JF - Psychiatric services (Washington, D.C.) AU - David, Daniella AU - Woodward, Claudia AU - Esquenazi, Jose AU - Mellman, Thomas A AD - Department of Psychiatry, Miami Veterans Affairs Medical Center, 1201 Northwest 16th Street, 116A12, Miami, Florida 33125, USA. daniella.david@med.va.gov Y1 - 2004/01// PY - 2004 DA - January 2004 SP - 82 EP - 85 VL - 55 IS - 1 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Florida KW - Male KW - Veterans KW - Stress Disorders, Post-Traumatic -- complications KW - Alcoholism -- diagnosis KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Diagnosis, Dual (Psychiatry) KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80075893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Comparison+of+comorbid+physical+illnesses+among+veterans+with+PTSD+and+veterans+with+alcohol+dependence.&rft.au=David%2C+Daniella%3BWoodward%2C+Claudia%3BEsquenazi%2C+Jose%3BMellman%2C+Thomas+A&rft.aulast=David&rft.aufirst=Daniella&rft.date=2004-01-01&rft.volume=55&rft.issue=1&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-22 N1 - Date created - 2003-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Over-the-counter analgesics in older adults: a call for improved labelling and consumer education. AN - 71996997; 15182214 AB - The use of analgesics increases with age and on any given day 20-30% of older adults take an analgesic medication. Over-the-counter (OTC) analgesics are generally well tolerated and effective when taken for brief periods of time and at recommended dosages. However, their long-term use, use at inappropriately high doses, or use by persons with contraindications may result in adverse effects, including gastrointestinal haemorrhage, cardiovascular toxicity, renal toxicity and hepatotoxicity. Many OTC drugs are also available through a prescription, for a broader range of indications and for longer durations of use and wider dose ranges, under the assumption that healthcare providers will help patients make safe choices about analgesics. Safe and effective use of medications is one of the greatest challenges faced by healthcare providers in medicine. More than 60% of people cannot identify the active ingredient in their brand of pain reliever. Additionally, about 40% of Americans believe that OTC drugs are too weak to cause any real harm. As a result of a recent US FDA policy, the conversion of prescription to OTC medications will result in a 50% increase of OTC medications. To reduce the risks of potential adverse effects from OTC drug therapy in older adults, we propose that the use of analgesics will be enhanced through the use of patient and healthcare provider education, as well as improved labelling of OTC analgesics. Improved labelling of OTC analgesics may help consumers distinguish common analgesic ingredients in a wide variety of preparations and facilitate informed decisions concerning the use of OTC drugs. Copyright 2004 Adis Data Information BV JF - Drugs & aging AU - Roumie, Christianne L AU - Griffin, Marie R AD - Quality Scholars Program, Veterans Administration, Tennessee Valley Healthcare System, Nashville, Tennessee 37212, USA. christianne.roumie@vanderbilt.edu Y1 - 2004 PY - 2004 DA - 2004 SP - 485 EP - 498 VL - 21 IS - 8 SN - 1170-229X, 1170-229X KW - Analgesics KW - 0 KW - Nonprescription Drugs KW - Index Medicus KW - Consumer Product Safety -- standards KW - Attitude to Health KW - Humans KW - Aged KW - Nonprescription Drugs -- adverse effects KW - Patient Education as Topic -- standards KW - Nonprescription Drugs -- therapeutic use KW - Self Medication -- trends KW - Nonprescription Drugs -- administration & dosage KW - Analgesics -- administration & dosage KW - Analgesics -- adverse effects KW - Drug Labeling -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71996997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drugs+%26+aging&rft.atitle=Over-the-counter+analgesics+in+older+adults%3A+a+call+for+improved+labelling+and+consumer+education.&rft.au=Roumie%2C+Christianne+L%3BGriffin%2C+Marie+R&rft.aulast=Roumie&rft.aufirst=Christianne&rft.date=2004-01-01&rft.volume=21&rft.issue=8&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Drugs+%26+aging&rft.issn=1170229X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-10-07 N1 - Date created - 2004-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Developmental stuttering: manifestations, treatment and dental implications. AN - 71942711; 15157054 AB - Developmental stuttering (DS) is a disturbance in the normal fluency and time patterning of speech resulting in involuntary repetition, prolongation, or cessation of sound. The scientific literature has implicated the lack of strong left cerebral dominance and abnormal levels of the neurotransmitters dopamine and possibly serotonin in regions of the brain controlling the coordination of language processing and motor activity of the vocal apparatus as possible causative factors in DS. Speech-language therapy is the most common form of treatment, but antipsychotic, antidepressant, and anxiolytic medications may be prescribed for some children and adults with persistent stuttering. These medications may cause xerostomia and adversely interact with certain antibiotics, analgesics, and sedatives routinely used in dentistry. Some people who stutter have sensory-motor and tactile-proprioceptive deficits that impede accurate and timely movements of the mandible, lips, and tongue, necessitating protection of the airway by staff during dental care. JF - Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry AU - Friedlander, Arthur H AU - Noffsinger, Douglas AU - Mendez, Mario F AU - Yagiela, John A AD - Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA. arthur.friedlander@med.va.gov PY - 2004 SP - 7 EP - 12 VL - 24 IS - 1 SN - 0275-1879, 0275-1879 KW - Anti-Anxiety Agents KW - 0 KW - Antidepressive Agents, Tricyclic KW - Antipsychotic Agents KW - Serotonin Uptake Inhibitors KW - Dentistry KW - Xerostomia -- chemically induced KW - Humans KW - Anti-Anxiety Agents -- adverse effects KW - Antidepressive Agents, Tricyclic -- adverse effects KW - Dominance, Cerebral KW - Antipsychotic Agents -- adverse effects KW - Serotonin Uptake Inhibitors -- adverse effects KW - Stuttering -- drug therapy KW - Stuttering -- physiopathology KW - Dental Care for Chronically Ill UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71942711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Special+care+in+dentistry+%3A+official+publication+of+the+American+Association+of+Hospital+Dentists%2C+the+Academy+of+Dentistry+for+the+Handicapped%2C+and+the+American+Society+for+Geriatric+Dentistry&rft.atitle=Developmental+stuttering%3A+manifestations%2C+treatment+and+dental+implications.&rft.au=Friedlander%2C+Arthur+H%3BNoffsinger%2C+Douglas%3BMendez%2C+Mario+F%3BYagiela%2C+John+A&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2004-01-01&rft.volume=24&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Special+care+in+dentistry+%3A+official+publication+of+the+American+Association+of+Hospital+Dentists%2C+the+Academy+of+Dentistry+for+the+Handicapped%2C+and+the+American+Society+for+Geriatric+Dentistry&rft.issn=02751879&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-06-07 N1 - Date created - 2004-05-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Selective serotonin reuptake inhibitor-related extrapyramidal symptoms in autistic children: a case series. AN - 71935495; 15142402 AB - Abnormal movements occur rarely with selective serotonin reuptake inhibitors (SSRIs). This report describes four consecutive autistic children who developed extrapyramidal side effects (EPS) following SSRI exposure. Videotapes, physician notes, and parental interviews were used retrospectively to rate symptoms on the Extrapyramidal Symptom Rating Scale. Findings suggest that EPS is a potential complication of SSRI treatment in autistic children. JF - Journal of child and adolescent psychopharmacology AU - Sokolski, Kenneth N AU - Chicz-Demet, Aleksandra AU - Demet, Edward M AD - Mental Health Care Group, Veterans Affairs Medical Center, Long Beach, California, USA. Kenneth.Sokolski@med.va.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 143 EP - 147 VL - 14 IS - 1 SN - 1044-5463, 1044-5463 KW - Serotonin Uptake Inhibitors KW - 0 KW - Index Medicus KW - Humans KW - Basal Ganglia Diseases -- psychology KW - Child KW - Male KW - Basal Ganglia Diseases -- chemically induced KW - Dyskinesia, Drug-Induced -- psychology KW - Dyskinesia, Drug-Induced -- diagnosis KW - Autistic Disorder -- drug therapy KW - Autistic Disorder -- psychology KW - Serotonin Uptake Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71935495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+child+and+adolescent+psychopharmacology&rft.atitle=Selective+serotonin+reuptake+inhibitor-related+extrapyramidal+symptoms+in+autistic+children%3A+a+case+series.&rft.au=Sokolski%2C+Kenneth+N%3BChicz-Demet%2C+Aleksandra%3BDemet%2C+Edward+M&rft.aulast=Sokolski&rft.aufirst=Kenneth&rft.date=2004-01-01&rft.volume=14&rft.issue=1&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Journal+of+child+and+adolescent+psychopharmacology&rft.issn=10445463&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-17 N1 - Date created - 2004-05-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Child Adolesc Psychopharmacol. 2005 Apr;15(2):150-1; author reply 152 [15910197] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - [d-Ala2,N-MePhe4,Gly-ol5]enkephalin-induced internalization of the micro opioid receptor in the spinal cord of morphine tolerant rats. AN - 71856903; 15099667 AB - Several theories of opioid tolerance predict that the magnitude of micro opioid receptor (MOR) internalization in response to ligand changes in the setting of morphine tolerance. Here we show that in rats rendered tolerant to the analgesic action of morphine, cross-tolerance to the analgesic action of intrathecally administered [d-Ala2,N-MePhe4,Gly-ol5]enkephalin (DAMGO) can be produced without changes in the magnitude of DAMGO-induced internalization of the MOR in lamina II neurons of the rat spinal cord. These results suggest that opioid tolerance-related changes in signaling are located downstream from or in parallel with receptor activation and internalization and support the idea that key features of opioid signaling are maintained, rather than reduced, in the setting of morphine tolerance. JF - Neuroscience AU - Trafton, J A AU - Basbaum, A I AD - Departments of Anatomy and Physiology and W. M. Keck Foundation for Integrative Neuroscience, University of California at San Francisco, San Francisco, CA 94143, USA. jodie.trafton@med.va.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 541 EP - 543 VL - 125 IS - 3 SN - 0306-4522, 0306-4522 KW - Narcotics KW - 0 KW - Receptors, Opioid, mu KW - Enkephalin, Ala(2)-MePhe(4)-Gly(5)- KW - 100929-53-1 KW - Index Medicus KW - Rats KW - Signal Transduction -- physiology KW - Animals KW - Rats, Sprague-Dawley KW - Enkephalin, Ala(2)-MePhe(4)-Gly(5)- -- pharmacology KW - Protein Transport -- drug effects KW - Signal Transduction -- drug effects KW - Endocytosis -- drug effects KW - Narcotics -- pharmacology KW - Protein Transport -- physiology KW - Male KW - Posterior Horn Cells -- cytology KW - Opioid-Related Disorders -- physiopathology KW - Opioid-Related Disorders -- metabolism KW - Spinal Cord -- metabolism KW - Posterior Horn Cells -- metabolism KW - Posterior Horn Cells -- drug effects KW - Drug Tolerance -- physiology KW - Spinal Cord -- drug effects KW - Receptors, Opioid, mu -- drug effects KW - Receptors, Opioid, mu -- metabolism KW - Spinal Cord -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71856903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=%5Bd-Ala2%2CN-MePhe4%2CGly-ol5%5Denkephalin-induced+internalization+of+the+micro+opioid+receptor+in+the+spinal+cord+of+morphine+tolerant+rats.&rft.au=Trafton%2C+J+A%3BBasbaum%2C+A+I&rft.aulast=Trafton&rft.aufirst=J&rft.date=2004-01-01&rft.volume=125&rft.issue=3&rft.spage=541&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-02 N1 - Date created - 2004-04-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vivo electrical stimulation of rabbit retina with a microfabricated array: strategies to maximize responses for prospective assessment of stimulus efficacy and biocompatibility. AN - 67273272; 15798362 AB - Our primary goal was to assess the effects of varying stimulus parameters on the electrically evoked cortical potentials (EECPs) in rabbits, which we intend to use as one measure of biocompatibility of implanted retinal prosthetic devices. We also sought to exclude contamination of waveforms recorded over the occipital cortex from electrical activity from the retina and the degree of reproducibility of EECP recordings. A concentric bipolar platinum electrode or microfabricated 5x5 electrode array delivered current to the retina of 43 Dutch-belted rabbits while the EECP was recorded from extradural electrodes over the occipital cortex. Electroretinogram (ERG) and visual evoked cortical potential (VECP) recordings were routinely obtained. Verification that occipital cortical recordings were not heavily contaminated by electrical potentials from the retina (i.e. the "validity" of the cortical recordings) was made by recording retinal and brain responses before and after intravitreal injection of tetrodotoxin. Electrical stimulation of the retina was performed with monopolar (with distant return) or bipolar electrode configurations. Cortical responses were computer-averaged over 100-500 stimulations. The effect of variation in stimulus current, charge, duration, frequency, polarity and spatial orientation of stimulating electrodes on cortical responses was studied. Progressive reduction of responses toward the anterior skull and abolition of posterior recordings by tetrodotoxin indicated that retinal activity did not significantly contaminate EECP recordings. Reproducibility testing revealed that inter-animal variability within the first hour of testing across all animals was not significantly greater than that found during prolonged testing of a single animal. The lowest current that yielded a reproducible EECP with monopolar stimulation was 75 microA (total current through 21 electrodes) using 200 microsec pulses, which yielded a 45 microV cortical response. Strength-duration curves were generally flat for fixed charge stimulation and linear for fixed current stimulation, at least up to a saturation point, which occurred at very high charge. Over 0.5-16 Hz stimulus frequencies, ERGs varied little but evoked potential responses showed a monotonic decline in amplitude at higher frequencies. Large negative-going initial pulses of a biphasic pair yielded the largest cortical amplitudes. EECP amplitudes varied significantly with the orientation of stimulating electrodes on the retina. This study provides novel data on the reproducibility of EECP recordings, and insight into stimulation parameters that affect retinal and cortical responses. This information can be used to improve the yield of retinal and evoked potential recordings, which will enhance the prospective assessment of the efficacy of stimulation and health of the stimulated tissues following. JF - Restorative neurology and neuroscience AU - Rizzo, Joseph F AU - Goldbaum, Sumiko AU - Shahin, Mohamed AU - Denison, Timothy J AU - Wyatt, John AD - Center for Innovative Visual Rehabilitation, Boston Veterans Administration Hospital, Boston, MA, USA. Y1 - 2004 PY - 2004 DA - 2004 SP - 429 EP - 443 VL - 22 IS - 6 SN - 0922-6028, 0922-6028 KW - Anesthetics, Local KW - 0 KW - Tetrodotoxin KW - 4368-28-9 KW - Index Medicus KW - Animals KW - Orientation -- physiology KW - Reproducibility of Results KW - Anesthetics, Local -- pharmacology KW - Rabbits KW - Dose-Response Relationship, Radiation KW - Reaction Time -- physiology KW - Photic Stimulation -- methods KW - Reaction Time -- radiation effects KW - Brain Mapping KW - Electroretinography -- methods KW - Prospective Studies KW - Orientation -- radiation effects KW - Computer-Aided Design KW - Tetrodotoxin -- pharmacology KW - Time Factors KW - Microelectrodes KW - Evoked Potentials, Visual -- drug effects KW - Occipital Lobe -- physiology KW - Retina -- physiology KW - Electrodes, Implanted KW - Evoked Potentials, Visual -- radiation effects KW - Occipital Lobe -- radiation effects KW - Electric Stimulation KW - Retina -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67273272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Restorative+neurology+and+neuroscience&rft.atitle=In+vivo+electrical+stimulation+of+rabbit+retina+with+a+microfabricated+array%3A+strategies+to+maximize+responses+for+prospective+assessment+of+stimulus+efficacy+and+biocompatibility.&rft.au=Rizzo%2C+Joseph+F%3BGoldbaum%2C+Sumiko%3BShahin%2C+Mohamed%3BDenison%2C+Timothy+J%3BWyatt%2C+John&rft.aulast=Rizzo&rft.aufirst=Joseph&rft.date=2004-01-01&rft.volume=22&rft.issue=6&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Restorative+neurology+and+neuroscience&rft.issn=09226028&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-06 N1 - Date created - 2005-03-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Suicide: a focus on primary care. AN - 67203486; 15622827 AB - The judgment of the primary care physician is critical in preventing suicide since most mental health care is provided by a primary care doctor. This article will briefly discuss the epidemiology of suicide, then turn to the pragmatic assessment of suicide in the primary care office and treatment issues in patients with elevated suicide risk. Special attention is paid to the risk of suicide with antidepressants because of the recent publicity and the concerns many practitioners have expressed. JF - WMJ : official publication of the State Medical Society of Wisconsin AU - Gillmore, John M AU - Chan, Carlyle H AD - Clement J Zablocki Veterans Administration Medical Center, USA. Y1 - 2004 PY - 2004 DA - 2004 SP - 88 EP - 92 VL - 103 IS - 6 SN - 1098-1861, 1098-1861 KW - Antidepressive Agents KW - 0 KW - Index Medicus KW - Risk Factors KW - Humans KW - Depressive Disorder -- diagnosis KW - Antidepressive Agents -- therapeutic use KW - Antidepressive Agents -- adverse effects KW - Primary Health Care KW - Suicide -- statistics & numerical data KW - Suicide -- psychology KW - Suicide -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67203486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=WMJ+%3A+official+publication+of+the+State+Medical+Society+of+Wisconsin&rft.atitle=Suicide%3A+a+focus+on+primary+care.&rft.au=Gillmore%2C+John+M%3BChan%2C+Carlyle+H&rft.aulast=Gillmore&rft.aufirst=John&rft.date=2004-01-01&rft.volume=103&rft.issue=6&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=WMJ+%3A+official+publication+of+the+State+Medical+Society+of+Wisconsin&rft.issn=10981861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-02-01 N1 - Date created - 2004-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Schizophrenia and obesity: impact of antipsychotic medications. AN - 67184303; 15600381 AB - Obesity is an epidemic in this country and much of the rest of the developed world. It is a major contributor to a range of metabolic disorders responsible for much of the medical morbidity and mortality that burden our society. The combination of the costs to society of the chronic illness of schizophrenia with the costs of obesity and the chronic illnesses associated with it, e.g., metabolic disorders, diabetes, dyslipidemias, and cardiovascular disease, represents a major public health problem. Obesity in schizophrenia is accentuated even further largely through illness-related factors, like poor dietary conditions and more sedentary lifestyles, and particularly because many of the psychiatric medications (antipsychotics, mood stabilizers, and antidepressants) used to combat this devastating illness themselves result in weight gain that, if untreated, may result in the usual obesity-associated morbidity and mortality. This article is intended to review some of the physiology of obesity and obesity-related metabolic disorders, the risks to schizophrenia patients engendered by obesity, the evidence for weight gain associated with the antipsychotic drugs, and the possible mechanisms involved in antipsychotic medication-associated weight gain. JF - The Journal of clinical psychiatry AU - Wirshing, Donna A AD - Department of Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. Donna.Wirshing@med.va.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 13 EP - 26 VL - 65 Suppl 18 SN - 0160-6689, 0160-6689 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Weight Gain -- drug effects KW - Behavior Therapy KW - Risk Factors KW - Humans KW - United States -- epidemiology KW - Comorbidity KW - Prevalence KW - Obesity -- therapy KW - Antipsychotic Agents -- therapeutic use KW - Antipsychotic Agents -- pharmacology KW - Schizophrenia -- drug therapy KW - Schizophrenia -- epidemiology KW - Obesity -- epidemiology KW - Antipsychotic Agents -- adverse effects KW - Obesity -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67184303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Schizophrenia+and+obesity%3A+impact+of+antipsychotic+medications.&rft.au=Wirshing%2C+Donna+A&rft.aulast=Wirshing&rft.aufirst=Donna&rft.date=2004-01-01&rft.volume=65+Suppl+18&rft.issue=&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-02-01 N1 - Date created - 2004-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Addiction training scale: pilot study of a self-report evaluation tool for psychiatry residents. AN - 67013064; 15507555 AB - Alcohol and drug dependence disorders have become common public health hazards. Psychiatrists encounter these problems in a major portion of their patients. However, recent data suggest that their training does not provide them the confidence to treat these disorders. Current methods of evaluating residents fail to adequately ascertain the lack of confidence in substance abuse training. Here, we present the Addiction Training Scale (ATS) that we developed to help trainers identify deficits in residents' substance abuse training. We developed the ATS and conducted a pilot study with the psychiatry residents at the Creighton University Department of Psychiatry, to test the validity of the ATS as a self-report evaluation tool to measure the level of psychiatry residents' preparedness in treating substance abuse disorders. Our results suggest that the ATS is related to the confidence and preparedness that residents express in their ability to treat substance abuse problems. The ATS may be beneficial in assessing psychiatry residents' substance abuse training and identifying deficits, which may be addressed during training. JF - Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry AU - Sattar, S Pirzada AU - Madison, James AU - Markert, Ronald J AU - Bhatia, Subhash C AU - Petty, Frederick AD - Creighton University School of Medicine, Omaha, Nebraska 68131, USA. syed.sattar@med.va.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 204 EP - 208 VL - 28 IS - 3 SN - 1042-9670, 1042-9670 KW - Index Medicus KW - Substance-Related Disorders -- therapy KW - Humans KW - Surveys and Questionnaires KW - Pilot Projects KW - Education KW - Internship and Residency -- standards KW - Psychiatry -- education KW - Professional Competence KW - Self-Assessment KW - Psychiatry -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67013064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Academic+psychiatry+%3A+the+journal+of+the+American+Association+of+Directors+of+Psychiatric+Residency+Training+and+the+Association+for+Academic+Psychiatry&rft.atitle=Addiction+training+scale%3A+pilot+study+of+a+self-report+evaluation+tool+for+psychiatry+residents.&rft.au=Sattar%2C+S+Pirzada%3BMadison%2C+James%3BMarkert%2C+Ronald+J%3BBhatia%2C+Subhash+C%3BPetty%2C+Frederick&rft.aulast=Sattar&rft.aufirst=S&rft.date=2004-01-01&rft.volume=28&rft.issue=3&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Academic+psychiatry+%3A+the+journal+of+the+American+Association+of+Directors+of+Psychiatric+Residency+Training+and+the+Association+for+Academic+Psychiatry&rft.issn=10429670&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-03-18 N1 - Date created - 2004-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bupreorphine:a new pharmacotherapy for opioid addictions treatment. AN - 66870977; 15364630 AB - The federal Drug Abuse Treatment Act 2000 (DATA) opened a window of opportunity for patients with the disease of addiction by providing increased access to options for treatment. Previously, only methadone maintenance, approved for use only through specially regulated clinics, was available to treat opioid addiction. DATA allows any physician choosing to take a short specialty training course and become certified to prescribe buprenorphine. Buprenorphine and buprenorphine/ naloxone (Subutex, Suboxone) can be prescribed by certified physicians in a traditional office setting to treat patients with opioid dependence. Clinical studies indicate buprenorphine maintenance is as effective as methadone maintenance in retaining patients in substance abuse treatment and reducing illicit opioid use. Sublingual buprenorphine is more effective than clonidine or clonidine/naltrexone in short-term opioid detoxification treatment. Buprenorphine provides an additional tool to treat opioid addiction and improve the quality of lives of these patients. More physicians are needed to treat patients with addiction. DATA facilitates this by removing existing barriers and increasing access to treatment. JF - Journal of pain & palliative care pharmacotherapy AU - Stock, Christopher AU - Shum, Jason H AD - George E. Wahlen Veterans Affairs Salt Lake City Health Care System, Salt Lake City, UT 84148, USA. christopher.stock@med.va.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 35 EP - 54 VL - 18 IS - 3 SN - 1536-0288, 1536-0288 KW - Narcotic Antagonists KW - 0 KW - Buprenorphine KW - 40D3SCR4GZ KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Drug Interactions KW - Humans KW - Biological Availability KW - Narcotic Antagonists -- pharmacokinetics KW - Buprenorphine -- metabolism KW - Buprenorphine -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Buprenorphine -- pharmacokinetics KW - Narcotic Antagonists -- metabolism KW - Opioid-Related Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66870977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pain+%26+palliative+care+pharmacotherapy&rft.atitle=Bupreorphine%3Aa+new+pharmacotherapy+for+opioid+addictions+treatment.&rft.au=Stock%2C+Christopher%3BShum%2C+Jason+H&rft.aulast=Stock&rft.aufirst=Christopher&rft.date=2004-01-01&rft.volume=18&rft.issue=3&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Journal+of+pain+%26+palliative+care+pharmacotherapy&rft.issn=15360288&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-01-18 N1 - Date created - 2004-09-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lewy body dementia: the litmus test for neuroleptic sensitivity and extrapyramidal symptoms. AN - 66730580; 15264967 AB - Lewy body dementia, also referred to as dementia with Lewy bodies (DLB), is a neurodegenerative disorder now considered to be the second most common cause of dementia after Alzheimer's disease. Postmortem findings suggest that DLB accounts for 20% to 34% of all dementia cases and is often underdiagnosed. Salient features of DLB include fluctuations in cognition, perceptual abnormalities (e.g., visual hallucinations), and mild parkinsonism. Other symptoms include frequent falls, nighttime agitation, and depression. DLB symptomatology can be partly explained by the extensive destruction of dopaminergic and acetylcholinergic pathways caused by neurodegeneration. For this reason, DLB patients are especially vulnerable to the antidopaminergic and anticholinergic actions of most conventional antipsychotics, which makes treatment of the psychotic symptoms of DLB extremely difficult. Patients are particularly sensitive to developing extrapyramidal symptoms (EPS) and also to the potentially fatal complication of neuroleptic sensitivity, which affects approximately 50% of DLB patients. Therefore, a need exists for antipsychotic drugs with less propensity to induce EPS and reduced affinity for dopamine and acetylcholine receptors. Here we review studies evaluating the efficacy and tolerability of atypical antipsychotics for the treatment of psychoses associated with DLB. Olanzapine appears to be poorly tolerated, and risperidone has been associated with high risk of neuroleptic malignant syndrome. Clozapine use remains controversial because of its potent anticholinergic action and risk of agranulocytosis. Quetiapine has been shown to reduce psychiatric manifestations of DLB without causing neuroleptic sensitivity or increasing EPS. Hence, quetiapine is an attractive candidate for the treatment of psychoses in DLB and other dementias. JF - The Journal of clinical psychiatry AU - Baskys, Andrius AD - Department of Psychiatry and Human Behavior, University of California at Irvine, USA. andrius.baskys@med.va.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 16 EP - 22 VL - 65 Suppl 11 SN - 0160-6689, 0160-6689 KW - Antipsychotic Agents KW - 0 KW - Dibenzothiazepines KW - Benzodiazepines KW - 12794-10-4 KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Clozapine KW - J60AR2IKIC KW - Risperidone KW - L6UH7ZF8HC KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - Humans KW - Aged KW - Clozapine -- adverse effects KW - Parkinson Disease -- drug therapy KW - Controlled Clinical Trials as Topic KW - Benzodiazepines -- therapeutic use KW - Dibenzothiazepines -- adverse effects KW - Benzodiazepines -- adverse effects KW - Clozapine -- therapeutic use KW - Treatment Outcome KW - Risperidone -- adverse effects KW - Risperidone -- therapeutic use KW - Parkinson Disease -- psychology KW - Dibenzothiazepines -- therapeutic use KW - Psychotic Disorders -- psychology KW - Lewy Body Disease -- psychology KW - Antipsychotic Agents -- therapeutic use KW - Lewy Body Disease -- drug therapy KW - Antipsychotic Agents -- adverse effects KW - Basal Ganglia Diseases -- epidemiology KW - Psychotic Disorders -- drug therapy KW - Basal Ganglia Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66730580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Lewy+body+dementia%3A+the+litmus+test+for+neuroleptic+sensitivity+and+extrapyramidal+symptoms.&rft.au=Baskys%2C+Andrius&rft.aulast=Baskys&rft.aufirst=Andrius&rft.date=2004-01-01&rft.volume=65+Suppl+11&rft.issue=&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-19 N1 - Date created - 2004-07-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vocational Rehabilitation of Participants with Severe Substance Use Disorders in a VA Veterans Industries Program AN - 61519848; 200502399 AB - There are approximately 100 Veterans Industries work therapy programs in the Veterans Health Administration (VHA) throughout the US. The majority of participants are veterans with severe substance use disorders & their length of stay ranges from 3 to 12 months. This study examines the Veterans Industries work therapy model at one site where veterans are referred from an addictions partial hospitalization treatment program. The study period was from 1996-97 & includes 80 patients. The characteristics of the participants are described. Barriers to employment are identified including unemployment rates, homelessness, drug of choice, age, & disability status. Outcome rates are reported including employment, abstinence, & housing support. 1 Table, 15 References. Adapted from the source document. JF - Substance Use & Misuse AU - Kerrigan, Anthony J AU - Kaough, Judith E AU - Wilson, Bill L AU - Wilson, J Vaughn AU - Bostick, Rosie AD - Mental Health Care Line, Veterans Affairs Medical Center, Houston, TX kerrigan.anthonyj@med.va.gov Y1 - 2004///0, PY - 2004 DA - 0, 2004 SP - 2513 EP - 2523 VL - 39 IS - 13-14 SN - 1082-6084, 1082-6084 KW - Veterans KW - Treatment Outcomes KW - Substance Abuse KW - Treatment Programs KW - Vocational Rehabilitation KW - United States of America KW - Program Evaluation KW - Employment KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61519848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+Use+%26+Misuse&rft.atitle=Vocational+Rehabilitation+of+Participants+with+Severe+Substance+Use+Disorders+in+a+VA+Veterans+Industries+Program&rft.au=Kerrigan%2C+Anthony+J%3BKaough%2C+Judith+E%3BWilson%2C+Bill+L%3BWilson%2C+J+Vaughn%3BBostick%2C+Rosie&rft.aulast=Kerrigan&rft.aufirst=Anthony&rft.date=2004-01-01&rft.volume=39&rft.issue=13-14&rft.spage=2513&rft.isbn=&rft.btitle=&rft.title=Substance+Use+%26+Misuse&rft.issn=10826084&rft_id=info:doi/10.1081%2FLSUM-200034695 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Number of references - 15 N1 - Last updated - 2016-09-28 N1 - CODEN - SUMIFL N1 - SubjectsTermNotLitGenreText - Veterans; Substance Abuse; Treatment Outcomes; Treatment Programs; Vocational Rehabilitation; United States of America; Program Evaluation; Employment DO - http://dx.doi.org/10.1081/LSUM-200034695 ER - TY - JOUR T1 - Toward the Development of an Integral Approach to Social Work: Implications for Human Behavior Theory and Research AN - 61515105; 200501038 AB - The social work profession has often struggled with how to achieve the conceptual unity & coherence sought in theory, practice, policy, & education. This struggle has often included paradigmatic debates that serve to articulate the broader metatheoretical backgrounds & systems (epistemic domains) from which we understand human behavior. Integralism represents an approach that can potentially transcend social work's dialectical dilemma inherent within the debates between modern & postmodern influences. By combining the epistemological insights & value awareness of the various schools of postmodernism with the methodological & conceptual achievements of modernism, & the partial truths & insights of premodernism, a transcendent or integral approach is conceptualized. 3 Figures, 71 References. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Human Behavior in the Social Environment AU - Thomas, Philip E AD - School Social Work, Indiana U , Indianapolis Philip.thomas2@med.va.gov Y1 - 2004///0, PY - 2004 DA - 0, 2004 SP - 1 EP - 19 VL - 9 IS - 3 SN - 1091-1359, 1091-1359 KW - Postmodernism KW - Modernity KW - Social Work Theory KW - Social Behavior KW - Theory Practice Relationship KW - Social Work KW - Epistemology KW - article KW - 6111: social work theory/research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61515105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Human+Behavior+in+the+Social+Environment&rft.atitle=Toward+the+Development+of+an+Integral+Approach+to+Social+Work%3A+Implications+for+Human+Behavior+Theory+and+Research&rft.au=Thomas%2C+Philip+E&rft.aulast=Thomas&rft.aufirst=Philip&rft.date=2004-01-01&rft.volume=9&rft.issue=3&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Human+Behavior+in+the+Social+Environment&rft.issn=10911359&rft_id=info:doi/10.1300%2FJ137v09n03_01 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Number of references - 71 N1 - Last updated - 2016-09-28 N1 - CODEN - JHBEF2 N1 - SubjectsTermNotLitGenreText - Social Work; Theory Practice Relationship; Social Behavior; Epistemology; Social Work Theory; Postmodernism; Modernity DO - http://dx.doi.org/10.1300/J137v09n03_01 ER - TY - JOUR T1 - Caregiver Reports: A Systematic Method of Comparison with Clinical Impressions AN - 61501261; 200405001 AB - We describe one method for comparing clinician & caregiver perspectives on dementia patients, using 62 individuals (31 patients with formal diagnoses of dementia & each patient's primary caregiver) as study participants. Caregivers completed questionnaires about their perceived caregiver burden, their mood state, & various aspects of patients' functioning. For comparison purposes, both clinicians & caregivers completed ratings & rankings of dementia-related problems in four domains of functioning. A majority of clinician-caregiver comparisons were incongruent, predominately for patients with a moderate degree of dementia. Overall, caregiver burden & mood state were both significantly related to clinician-caregiver incongruence. 5 Tables, 32 References. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Clinical Gerontologist AU - Battista, Matthew A AU - Pate, Debra Sue AU - Hierholzer, Robert AU - Howsepian, A A AU - Mogelof, Jeffrey AD - VACCHCS Fresno, CA matthew.battista@med.va.gov Y1 - 2004///0, PY - 2004 DA - 0, 2004 SP - 53 EP - 70 VL - 27 IS - 4 SN - 0731-7115, 0731-7115 KW - dementia KW - Caregivers KW - Diagnosis KW - Senility KW - Elderly KW - Alzheimer's Disease KW - Physicians KW - Cognitive Functioning KW - Caregiver Burden KW - article KW - 6142: mental & emotional health problems KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61501261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Gerontologist&rft.atitle=Caregiver+Reports%3A+A+Systematic+Method+of+Comparison+with+Clinical+Impressions&rft.au=Battista%2C+Matthew+A%3BPate%2C+Debra+Sue%3BHierholzer%2C+Robert%3BHowsepian%2C+A+A%3BMogelof%2C+Jeffrey&rft.aulast=Battista&rft.aufirst=Matthew&rft.date=2004-01-01&rft.volume=27&rft.issue=4&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Clinical+Gerontologist&rft.issn=07317115&rft_id=info:doi/10.1300%2FJ018v27n04_06 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Number of references - 32 N1 - Last updated - 2016-09-28 N1 - CODEN - CLGEDA N1 - SubjectsTermNotLitGenreText - Alzheimer's Disease; Elderly; Diagnosis; Physicians; Caregivers; Cognitive Functioning; Senility; Caregiver Burden DO - http://dx.doi.org/10.1300/J018v27n04_06 ER - TY - JOUR T1 - Japanese American Caregivers of Individuals with Dementia: An Examination of Japanese Cultural Values and Dementia Caregiving AN - 61483132; 200403110 AB - As the population of the US continues to live longer than in previous years, a larger number of older adults are being diagnosed with dementia or other memory-related conditions. The individuals who experience a tremendous amount of stress & burden are the caregivers for the individual with dementia. The majority of the dementia caregiver research has been conducted on Caucasian caregivers, & to a lesser extent on Latino & African American caregivers. However, there is a paucity of research based on Japanese American caregivers. An understanding of how Japanese culture often affects Japanese American caregivers will assist clinicians in providing culturally competent health care to this group of caregivers. The authors provide an overview of the Japanese caregiver literature, followed by a discussion of traditional Japanese cultural values as they apply to a case example that illustrates the interaction of Japanese cultural values & dementia caregiving. 32 References. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Clinical Gerontologist AU - Kinoshita, Lisa M AU - Gallagher-Thompson, Dolores AD - Mental Illness Research/Education/Clinical Center, VA Palo Alto Health Care System, CA Lisa.kinoshita@med.va.gov Y1 - 2004///0, PY - 2004 DA - 0, 2004 SP - 87 EP - 102 VL - 27 IS - 1-2 SN - 0731-7115, 0731-7115 KW - Caregivers KW - Alzheimer's Disease KW - Cultural Values KW - Asian Americans KW - Cultural Sensitivity KW - Caregiver Burden KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61483132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Gerontologist&rft.atitle=Japanese+American+Caregivers+of+Individuals+with+Dementia%3A+An+Examination+of+Japanese+Cultural+Values+and+Dementia+Caregiving&rft.au=Kinoshita%2C+Lisa+M%3BGallagher-Thompson%2C+Dolores&rft.aulast=Kinoshita&rft.aufirst=Lisa&rft.date=2004-01-01&rft.volume=27&rft.issue=1-2&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Clinical+Gerontologist&rft.issn=07317115&rft_id=info:doi/10.1300%2FJ018v27n01_08 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Number of references - 32 N1 - Last updated - 2016-09-28 N1 - CODEN - CLGEDA N1 - SubjectsTermNotLitGenreText - Asian Americans; Caregivers; Cultural Values; Caregiver Burden; Cultural Sensitivity; Alzheimer's Disease DO - http://dx.doi.org/10.1300/J018v27n01_08 ER - TY - JOUR T1 - Developing Programs for Homeless Veterans: Understanding Driving Forces in Implementation AN - 61433692; 200503559 AB - Between 1992 & 2003, services for homeless veterans at the Veterans Affairs Greater Los Angeles Healthcare System went from inappropriate utilization of hospital medical & psychiatric beds, to a continuum of residential treatment, transitional housing, & employment programs through arrangements with private agencies. The authors use elements of Hasenfeld & Brock's Political Economy Model (1991) to explain this transformation in service delivery that was spearheaded by a VA social work leadership team. It is argued that three driving forces crucial to program implementation were present: technological certainty, economic stability, & concentration of power. Evidence of the implementation's impact includes creation of new homeless program beds, a reduction in use of medical/psychiatric beds, & a large number of formerly homeless veterans with housing & employment at program discharge. Study limitations & implications for future studies are discussed. 15 References. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Social Work in Health Care AU - Nakashima, John AU - McGuire, Jim AU - Berman, Stephen AU - Daniels, William AD - Community Care, VA Greater Los Angeles Healthcare System, CA john.nakashima@med.va.gov Y1 - 2004///0, PY - 2004 DA - 0, 2004 SP - 1 EP - 12 VL - 40 IS - 2 SN - 0098-1389, 0098-1389 KW - Los Angeles, California KW - Veterans KW - Housing KW - Program Implementation KW - Delivery Systems KW - Social Programs KW - Health Care Services KW - Homelessness KW - article KW - 6141: poverty & homelessness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61433692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=Developing+Programs+for+Homeless+Veterans%3A+Understanding+Driving+Forces+in+Implementation&rft.au=Nakashima%2C+John%3BMcGuire%2C+Jim%3BBerman%2C+Stephen%3BDaniels%2C+William&rft.aulast=Nakashima&rft.aufirst=John&rft.date=2004-01-01&rft.volume=40&rft.issue=2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/10.1300%2FJ010v40n02_01 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Number of references - 15 N1 - Last updated - 2016-09-28 N1 - CODEN - SWHCDO N1 - SubjectsTermNotLitGenreText - Veterans; Homelessness; Housing; Social Programs; Program Implementation; Health Care Services; Delivery Systems; Los Angeles, California DO - http://dx.doi.org/10.1300/J010v40n02_01 ER - TY - JOUR T1 - Understanding the Interface of HIV, Trauma, Post-Traumatic Stress Disorder, and Substance Use and Its Implications for Health Outcomes AN - 61380561; 200601178 AB - Many individuals living with HIV have been exposed to some type of traumatic event during their lives & may be living with symptoms of post-traumatic stress disorder (PTSD). A substantial number of these individuals are also likely to show evidence of a co-morbid substance use disorder (SUD). There is reason to believe that the co-occurrence of HIV & PTSD or co-morbid PTSD & SUD (PTSD/SUD) may predict poorer health outcomes. There are several pathways through which PTSD or PTSD/SUD might adversely impact the health of individuals living with HIV, including participation in negative health behaviours, low levels of adherence to antiretroviral medications, &/or a direct, deleterious effect on immune function. Psychological interventions are needed to treat PTSD & PTSD/SUD in HIV-positive individuals, & reduce the negative impact of these conditions on health outcomes. This article will explore data on the prevalence of trauma exposure, PTSD, & PTSD/SUD among individuals living with HIV, the pathways through which these conditions might affect health, possible interventions for PTSD & PTSD/SUD for individuals living with HIV, & methods for integrating care for individuals with these disorders. Future directions for research related to HIV, PTSD, & PTSD/SUD will also be discussed. References. Adapted from the source document. JF - AIDS Care AU - Brief, D J AU - Bollinger, A R AU - Vielhauer, M J AU - Berger-Greenstein, J A AU - Morgan, E E AU - Brady, S M AU - Buondonno, L M AU - Keane, T M AU - HIV/AIDS Treatment Adherence/Health Outcomes/Cost Study Grp AD - VA Boston Healthcare System, MA deborah.brief@med.va.gov Y1 - 2004///0, PY - 2004 DA - 0, 2004 SP - S97 EP - S120 VL - 16 SN - 0954-0121, 0954-0121 KW - Treatment Outcomes KW - Substance Abuse KW - Treatment Compliance KW - Acquired Immune Deficiency Syndrome KW - Interdisciplinary Approach KW - Posttraumatic Stress Disorder KW - Comorbidity KW - Health Care Services KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61380561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Care&rft.atitle=Understanding+the+Interface+of+HIV%2C+Trauma%2C+Post-Traumatic+Stress+Disorder%2C+and+Substance+Use+and+Its+Implications+for+Health+Outcomes&rft.au=Brief%2C+D+J%3BBollinger%2C+A+R%3BVielhauer%2C+M+J%3BBerger-Greenstein%2C+J+A%3BMorgan%2C+E+E%3BBrady%2C+S+M%3BBuondonno%2C+L+M%3BKeane%2C+T+M%3BHIV%2FAIDS+Treatment+Adherence%2FHealth+Outcomes%2FCost+Study+Grp&rft.aulast=Brief&rft.aufirst=D&rft.date=2004-01-01&rft.volume=16&rft.issue=&rft.spage=S97&rft.isbn=&rft.btitle=&rft.title=AIDS+Care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540120412301315259 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Number of references - 154 N1 - Last updated - 2016-09-28 N1 - CODEN - AIDCEF N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Comorbidity; Posttraumatic Stress Disorder; Substance Abuse; Treatment Compliance; Treatment Outcomes; Health Care Services; Interdisciplinary Approach DO - http://dx.doi.org/10.1080/09540120412301315259 ER - TY - JOUR T1 - Gender Differences in Identity Processes and Self-Esteem in Middle and Later Adulthood AN - 60494741; 200422434 AB - Gender differences were examined in the identity processes of identity assimilation (maintaining identity despite age changes), identity accommodation (changing identity) & balance (using both processes) & in the relationship of these processes to self-esteem. We tested a community sample of 222 adults (131 females & 91 males) ranging from 40 to 84 years of age (M = 57.5, SD = 12.1). Analysis of variance yielded evidence showing greater use of identity accommodation for women. Identity accommodation was negatively associated with self-esteem for both genders, while identity assimilation was positively associated with self-esteem for women only. For both men & women, identity balance was positively related to self-esteem. Women's use of the identity processes in relation to self-esteem is discussed. Societal views on aging are suggested to impact women, such that they engage in identity accommodation while benefiting from identity assimilation. From these findings, it appears that examining the processes contributing to the maintenance of self-esteem may be a more useful approach to characterizing the aging process & gender differences than focusing on mean differences alone. 2 Tables, 17 References. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Women & Aging AU - Skultety, Karyn M AU - Whitbourne, Susan Krauss AD - U Massachusetts, Amherst karyn.skultety@med.va.gov Y1 - 2004///0, PY - 2004 DA - 0, 2004 SP - 175 EP - 188 VL - 16 IS - 1-2 SN - 0895-2841, 0895-2841 KW - Self Esteem KW - Social Identity KW - Aging KW - Elderly KW - Sex Differences KW - Life Stage Transitions KW - Middle Aged Adults KW - Adjustment KW - article KW - 0312: social psychology; personality & social roles (individual traits, social identity, adjustment, conformism, & deviance) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60494741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Women+%26+Aging&rft.atitle=Gender+Differences+in+Identity+Processes+and+Self-Esteem+in+Middle+and+Later+Adulthood&rft.au=Skultety%2C+Karyn+M%3BWhitbourne%2C+Susan+Krauss&rft.aulast=Skultety&rft.aufirst=Karyn&rft.date=2004-01-01&rft.volume=16&rft.issue=1-2&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Journal+of+Women+%26+Aging&rft.issn=08952841&rft_id=info:doi/10.1300%2FJ074v16n01_12 LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Number of references - 17 N1 - Last updated - 2016-09-28 N1 - CODEN - JWAGE5 N1 - SubjectsTermNotLitGenreText - Social Identity; Sex Differences; Aging; Elderly; Middle Aged Adults; Life Stage Transitions; Self Esteem; Adjustment DO - http://dx.doi.org/10.1300/J074v16n01_12 ER - TY - JOUR T1 - Disrupted Bodies: Experiencing the Newly Limited Body in Stroke AN - 60099467; 200414224 AB - This article explores the intersection of recovery & bodily practices among stroke survivors. Drawing on the extensive literature on the socially constructed body in general, on chronic illness, & on interactionist thought, we explore bodily experience as a mechanism that informs stroke survivors' understanding & practices of everyday life in recovery. We ask a central question: what practical mechanisms does the survivor employ to provide meaning to her or his newly disrupted body? Data gathered from in-depth interviews with fifty-one discharged stroke survivors show that they use three specific technologies of bodily management & meaning-making. These are managing the body within a mind-body dualism, testing the body in its everyday practices, & orienting to the body as a biographically informed phenomenon. 46 References. Adapted from the source document. JF - Symbolic Interaction AU - Faircloth, Christopher A AU - Boylstein, Craig AU - Rittman, Maude AU - Young, Mary Ellen AD - Rehabilitation Outcomes Research Center, North Florida-South Georgia VA Medical Center, Gainesville, FL christopher.faircloth@med.va.gov Y1 - 2004/01// PY - 2004 DA - January 2004 SP - 71 EP - 87 VL - 27 IS - 1 SN - 0195-6086, 0195-6086 KW - Chronic Illness KW - Human Body KW - Embodiment KW - Social Constructionism KW - Social Interaction KW - article KW - 0373: social psychology; cognitive/interpretive sociologies, symbolic interactionism, & ethnomethodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60099467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Symbolic+Interaction&rft.atitle=Disrupted+Bodies%3A+Experiencing+the+Newly+Limited+Body+in+Stroke&rft.au=Faircloth%2C+Christopher+A%3BBoylstein%2C+Craig%3BRittman%2C+Maude%3BYoung%2C+Mary+Ellen&rft.aulast=Faircloth&rft.aufirst=Christopher&rft.date=2004-01-01&rft.volume=27&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Symbolic+Interaction&rft.issn=01956086&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-10-30 N1 - Number of references - 46 N1 - Last updated - 2016-09-28 N1 - CODEN - SYMIDD N1 - SubjectsTermNotLitGenreText - Chronic Illness; Social Interaction; Social Constructionism; Human Body; Embodiment ER - TY - JOUR T1 - The genetic relationship of personality to major depression and schizophrenia AN - 20137020; 10263074 AB - Since ancient times, dimensions of personality have been linked with the liability to psychiatric illness. In modern times, several research approaches suggest that personality and the liability to psychiatric illness such as schizophrenia and major depression (MD) are influenced by many of the same genes. If this is true, it could shed light on the genetic architecture of psychiatric illness. It could also validate the use of personality measures in unaffected relatives in linkage and association studies of psychiatric illness. This approach could potentially increase statistical power to detect genetic effects. The personality trait neuroticism (N) may be genetically related to MD, while schizotypal traits may be genetically related to schizophrenia. Twin studies have reported that most of the covariation between N and MD is due to shared additive genetic factors. Adoption studies have demonstrated that the biological offspring of schizophrenic mothers are more likely to have schizotypal personality disorder than are children of control mothers.At the current time, only one genome wide scan of N has been published, which does show some overlap in linkage results with genome scans of MD. However,this should be replicated and more rigorously studied. At the present time, there are no established susceptibility genes for MD. When these are established, it will be necessary to assess their relationship with N. Currently, no genome scans of schizotypy have been published. Furthermore, although several putative susceptibility genes for schizophrenia have been reported and replicated, only one -- catechol-O-methyltransferase (COMT) -- has been tested in schizotypy. JF - Neurotoxicity Research AU - Fanous, Ayman H AU - Kendler, Kenneth S AD - Washington VA Medical Center-Georgetown University Medical Center Schizophrenia Research Program, 50 Irving St. NW, 20422 Washington, DC, USA, ayman.fanous@med.va.gov Y1 - 2004/01// PY - 2004 DA - Jan 2004 SP - 43 EP - 50 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 6 IS - 1 SN - 1029-8428, 1029-8428 KW - Toxicology Abstracts; Genetics Abstracts; CSA Neurosciences Abstracts KW - Genomes KW - Genetic factors KW - Statistics KW - Depression KW - Neurosis KW - Personality KW - Adoption KW - Children KW - Genetic relationship KW - Schizophrenia KW - Mental disorders KW - Catechol O-methyltransferase KW - Twins KW - Neurotoxicity KW - Progeny KW - G 07880:Human Genetics KW - N3 11001:Behavioral and Cognitive Neuroscience KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20137020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicity+Research&rft.atitle=The+genetic+relationship+of+personality+to+major+depression+and+schizophrenia&rft.au=Fanous%2C+Ayman+H%3BKendler%2C+Kenneth+S&rft.aulast=Fanous&rft.aufirst=Ayman&rft.date=2004-01-01&rft.volume=6&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Neurotoxicity+Research&rft.issn=10298428&rft_id=info:doi/10.1007%2FBF03033295 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Genetic factors; Depression; Statistics; Personality; Neurosis; Adoption; Children; Schizophrenia; Genetic relationship; Mental disorders; Twins; Catechol O-methyltransferase; Neurotoxicity; Progeny DO - http://dx.doi.org/10.1007/BF03033295 ER - TY - JOUR T1 - Local ex vivo gene therapy with bone marrow stromal cells expressing human BMP4 promotes endosteal bone formation in mice AN - 19223712; 5805607 AB - Bone loss in osteoporosis is caused by an imbalance between resorption and formation on endosteal surfaces of trabecular and cortical bone. We investigated the feasibility of increasing endosteal bone formation in mice by ex vivo gene therapy with bone marrow stromal cells (MSCs) transduced with a MLV-based retroviral vector to express human bone morphogenetic protein 4 (BMP4). We assessed two approaches for administering transduced MSCs. beta -Galactosidase ( beta -Gal) transduced C57BL/6J mouse MSCs were injected intravenously via tail vein or directly injected into the femoral bone marrow cavity of non-marrow- ablated syngenic recipient mice and bone marrow cavity engraftment was assessed. BMP4- or beta -Gal-transduced cells were injected into the femoral bone marrow cavity and effects on bone were evaluated by X-ray, peripheral quantitative computed tomography (pQCT), and histology. After tail-vein injection less than 20% of recipient mice contained beta -Gal-positive donor cells in femur, humerus or vertebra marrow cavities combined, and in these mice only 0.02-0.29% of injected cells were present in the bone marrow. In contrast, direct intramedullary injection was always successful and an average of 2% of injected cells were present in the injected femur marrow cavity 24 hours after injection. Numbers of donor cells decreased over the next 14 days. Intramedullary injection of BMP4-transduced MSCs induced bone formation. Trabecular bone mineral density (BMD) determined by pQCT increased 20.5% at 14 days and total BMD increased 6.5% at 14 days and 10.4% at 56 days. The present findings support the feasibility of using ex vivo MSC-based retroviral gene therapy to induce relatively sustained new bone formation, with normal histological appearance, at endosteal bone sites. JF - Journal of Gene Medicine AU - Zhang, X S AU - Linkhart, T A AU - Chen, S-T AU - Peng, H AU - Wergedal, JE AU - Guttierez, G G AU - Sheng, MH-C AU - Lau, K-HW AU - Baylink, D J AD - Department of Medicine, Loma Linda University, and Gene Therapy Division, Musculoskeletal Disease Center (151), VA Loma Linda Healthcare Network, Loma Linda, CA 92357, USA, Tom.Linkhart@med.va.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 4 EP - 15 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 6 IS - 1 SN - 1099-498X, 1099-498X KW - mice KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Stroma KW - Gene therapy KW - Bone marrow KW - Bone density KW - Osteoporosis KW - b-Galactosidase KW - Bone morphogenetic protein 4 KW - Transduction KW - ^b-Galactosidase KW - G 07443:Gene therapy KW - W 30965:Miscellaneous, Reviews KW - W4 120:Genetic Engineering in Medicine KW - W3 33180:Gene based (protocols, clinical trials, and animal models) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19223712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Gene+Medicine&rft.atitle=Local+ex+vivo+gene+therapy+with+bone+marrow+stromal+cells+expressing+human+BMP4+promotes+endosteal+bone+formation+in+mice&rft.au=Zhang%2C+X+S%3BLinkhart%2C+T+A%3BChen%2C+S-T%3BPeng%2C+H%3BWergedal%2C+JE%3BGuttierez%2C+G+G%3BSheng%2C+MH-C%3BLau%2C+K-HW%3BBaylink%2C+D+J&rft.aulast=Zhang&rft.aufirst=X&rft.date=2004-01-01&rft.volume=6&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Journal+of+Gene+Medicine&rft.issn=1099498X&rft_id=info:doi/10.1002%2Fjgm.477 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bone morphogenetic protein 4; Bone density; b-Galactosidase; Osteoporosis; Transduction; Bone marrow; Stroma; Gene therapy; ^b-Galactosidase DO - http://dx.doi.org/10.1002/jgm.477 ER - TY - CONF T1 - An endotoxin:sCD14 complex is the preferred substrate for acyloxyacylhydrolase AN - 17798231; 6146708 AB - The removal of secondary fatty acyl chains contained in the lipid A component of endotoxin by treatment with the enzyme acyloxyacylhydrolase (AOAH), greatly modifies the pro-inflammatory potency of endotoxin from Gram-negative bacteria. While AOAH in intact host cells works efficiently against both isolated endotoxin and intact Gram-negative bacteria, purified enzyme requires low pH and detergent. To address the physiological form of the endotoxin substrate, we have compared the efficiency of AOAH to release metabolically labeled radioactive fatty acids from endotoxin isolated from Neisseria meningitidis (LOS) presented either as aggregates or as isolated, purified complexes with endotoxin-binding proteins (sCD14 or MD-2) that are necessary intermediates in endotoxin-dependent activation of TLR4. The experiments were carried out in balanced Hanks' buffer salt solution containing HEPES and 0.1% albumin. As judged by time and [AOAH] requirements, LOS:sCD14 was > 10 times more readily deacylated by AOAH than were LOS aggregates. In contrast, there is no apparent activity of AOAH on LOS presented as LOS:MD-2. These results support the suggestion that the lipid portion of endotoxin is deeply buried within a pocket of MD-2 and, thus, is rendered inaccessible to AOAH. The reactivity of LOS:sCD14 emphasizes the accessibility of the lipid A portion of LOS when bound to CD14, consistent with the need for albumin in its formation and stabilization. Our studies suggest the efficiency of deacylation of endotoxin by cellular AOAH may depend upon the transfer of endotoxin to mCD14, i.e. formation of an endotoxin:mCD14 complex. JF - Journal of Endotoxin Research AU - Gioannini, T L AU - Teghanemt, A AU - Zhang, D S AU - Weiss, J P Y1 - 2004 PY - 2004 DA - 2004 SP - 125 PB - W.S. Maney & Son Ltd., Hudson Road Leeds LS9 7DL UK, [URL:http://www.ingenta.com] VL - 10 IS - 5 KW - acyloxyacyl hydrolase KW - Microbiology Abstracts B: Bacteriology KW - Salts KW - Deacylation KW - Detergents KW - Gram-negative bacteria KW - Albumin KW - Fatty acids KW - Lipid A KW - Neisseria meningitidis KW - CD14 antigen KW - TLR4 protein KW - Toll-like receptors KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17798231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Endotoxin+Research&rft.atitle=An+endotoxin%3AsCD14+complex+is+the+preferred+substrate+for+acyloxyacylhydrolase&rft.au=Gioannini%2C+T+L%3BTeghanemt%2C+A%3BZhang%2C+D+S%3BWeiss%2C+J+P&rft.aulast=Gioannini&rft.aufirst=T&rft.date=2004-01-01&rft.volume=10&rft.issue=5&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Journal+of+Endotoxin+Research&rft.issn=09680519&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - CONF T1 - Francisella tularensis live vaccine strain lipopolysaccharide does not bind to lipopolysaccharide binding protein AN - 17797447; 6146672 AB - Francisella tularensis is a facultative intracellular Gram-negative bacterium that can cause overwhelming sepsis at a small inoculum. The lipopolysaccharide (LPS) of F. tularensis neither activates endotoxin-responsive human cells nor antagonizes cell activation by potent LPS species. LPS binding to lipopolysaccharide binding protein (LBP) is the first step in potent pro-inflammatory host responses to LPS. We hypothesized that the functionally inert properties of F. tularensis LPS could be due to an inability to bind LBP. We investigated the binding of F. tularensis live vaccine strain LPS to LBP using competition assays. In the initial experiments, LBP was adsorbed to a polystyrene plate, and we measured binding of [ super(3)H]-lipo-oligosaccharide (LOS) from Neisseria meningitidis. Cold N. meningitidis LOS competed with the [ super(3)H]-LOS, with a 10-fold excess of cold LOS inhibiting by 57% (SD plus or minus 3%) [ super(3)H]-LOS binding to LBP and a 100-fold excess inhibiting by 79% ( plus or minus 6%). By contrast, F. tularensis LPS showed no competition at a 10-fold excess and inhibited by only 23% ( plus or minus 12%) and 30% ( plus or minus 6%) at 100 and 1000-fold excesses, respectively. Because adsorbed LBP may not mimic LBP in its more physiological soluble form, we conducted an immune capture assay in which adsorbed polyclonal antibody to LBP pulled down LBP-[ super(3)H]-LOS complexes. When cold LOS was co-incubated with LBP and [ super(3)H]-LOS, a 10-fold excess of cold LOS fully abrogated formation of LBP-[ super(3)H]-LOS complexes. By contrast, 10- and 100-fold excesses of F. tularensis LPS had no effect on formation of LBP-[ super(3)H]-LOS complexes. Thus, F. tularensis LPS shows little or no binding to LBP. This inability to bind LBP may explain why F. tularensis LPS does not interact with host LPS-sensing machinery. JF - Journal of Endotoxin Research AU - Barker, J H AU - Weiss, J AU - Apicella, MA AU - Nauseef, WM Y1 - 2004 PY - 2004 DA - 2004 SP - 61 EP - 62 PB - W.S. Maney & Son Ltd., Hudson Road Leeds LS9 7DL UK, [URL:http://www.ingenta.com] VL - 10 IS - 5 KW - Microbiology Abstracts B: Bacteriology KW - Sepsis KW - Antibodies KW - polystyrene KW - Lipopolysaccharides KW - Francisella tularensis KW - Vaccines KW - Neisseria meningitidis KW - Cell activation KW - J 02834:Vaccination and immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17797447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Endotoxin+Research&rft.atitle=Francisella+tularensis+live+vaccine+strain+lipopolysaccharide+does+not+bind+to+lipopolysaccharide+binding+protein&rft.au=Barker%2C+J+H%3BWeiss%2C+J%3BApicella%2C+MA%3BNauseef%2C+WM&rft.aulast=Barker&rft.aufirst=J&rft.date=2004-01-01&rft.volume=10&rft.issue=5&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Journal+of+Endotoxin+Research&rft.issn=09680519&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Characterization of triacsin C inhibition of short-, medium-, and long-chain fatty acid:CoA ligases of human liver AN - 17757718; 6058938 AB - Short-, medium-, and long-chain fatty acid:CoA ligases from human liver were tested for their sensitivity to inhibition by triacsin C. The short-chain fatty acid:CoA ligase was inhibited less than 10% by concentrations of triacsin C as high as 80 mu M. The two mitochondrial xenobiotic/medium-chain fatty acid:CoA ligases (XM-ligases), HXM-A and HXM-B, were partially inhibited by triacsin C, and the inhibitions were characterized by low affinity for triacsin C (K sub(I) values > 100 mu M). These inhibitions were found to be the result of triacsin C competing with medium-chain fatty acid for binding at the active site. The microsomal and mitochondrial forms of long-chain fatty acid:CoA ligase (also termed long-chain fatty acyl-CoA synthetase, or long-chain acyl-CoA synthetase LACS) were potently inhibited by triacsin C, and the inhibition had identical characteristics for both LACS forms. Dixon plots of this inhibition were biphasic. There is a high-affinity site with a K sub(I) of 0.1 mu M that accounts for a maximum of 70% of the inhibition. There is also a low affinity site with a K sub(I) of 6 mu M that accounts for a maximum of 30% inhibition. Kinetic analysis revealed that the high-affinity inhibition of the mitochondrial and microsomal LACS forms is the result of triacsin C binding at the palmitate substrate site. The high-affinity triacsin C inhibition of both the mitochondrial and microsomal LACS forms was found to require a high concentration of free Mg super(2+), with the EC sub(50) for inhibition being 3 mM free Mg super(2+). The low affinity triacsin C inhibition was also enhanced by Mg super(2+). The data suggests that Mg super(2+) promotes triacsin C inhibition of LACS by enhancing binding at the palmitate binding site. In contrast, the partial inhibition of the XM-ligases by triacsin C, which showed only a low-affinity component, did not require Mg super(2+). JF - Journal of Biochemical and Molecular Toxicology AU - Vessey, Donald A AU - Kelley, Michael AU - Warren, Robert S AD - Liver Study Unit, Department of Veterans' Affairs Medical Center, San Francisco, CA 94121, USA, donald.vessey@med.va.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 100 EP - 106 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 18 IS - 2 SN - 1095-6670, 1095-6670 KW - triacsin C KW - Toxicology Abstracts KW - Acyl-CoA Synthetase KW - Fatty Acid:CoA Ligase KW - Triacsin C KW - Kinetics KW - Liver KW - Fatty acids KW - Mitochondria KW - Long-chain-fatty-acid-CoA ligase KW - Xenobiotics KW - Magnesium KW - X 24171:Microbial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17757718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biochemical+and+Molecular+Toxicology&rft.atitle=Characterization+of+triacsin+C+inhibition+of+short-%2C+medium-%2C+and+long-chain+fatty+acid%3ACoA+ligases+of+human+liver&rft.au=Vessey%2C+Donald+A%3BKelley%2C+Michael%3BWarren%2C+Robert+S&rft.aulast=Vessey&rft.aufirst=Donald&rft.date=2004-01-01&rft.volume=18&rft.issue=2&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biochemical+and+Molecular+Toxicology&rft.issn=10956670&rft_id=info:doi/10.1002%2Fjbt.20009 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Kinetics; Fatty acids; Liver; Mitochondria; Long-chain-fatty-acid-CoA ligase; Xenobiotics; Magnesium DO - http://dx.doi.org/10.1002/jbt.20009 ER - TY - JOUR T1 - Recurrent Mycobacterium xenopi Infection in a Patient with Rheumatoid Arthritis Receiving Etanercept AN - 17713978; 5890876 AB - A case of recurrent Mycobacterium xenopi infection presenting as Pott's disease in a patient receiving etanercept for severe rheumatoid arthritis is described. A 49-y-old Caucasian male had received a total of 11 months of anti-mycobacterial therapy for hip infection acquired 15 months earlier; he presented with progressive back pain, which was diagnosed as Pott's disease. He had been treated with etanercept in addition to his prior immunosuppressive agents after the diagnosis of hip infection. JF - Scandinavian Journal of Infectious Diseases AU - Yim, Kyongwook AU - Nazeer, SH AU - Kiska, D AU - Rose, F B AU - Brown, D AU - Cynamon, M H AD - Department of Medicine, Syracuse VA Medical Center, 800 Irving Avenue, Syracuse, NY 13210, USA, michael.cynamon@med.va.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 150 VL - 36 IS - 2 SN - 0036-5548, 0036-5548 KW - Back pain KW - Microbiology Abstracts B: Bacteriology KW - etanercept KW - Rheumatoid arthritis KW - Mycobacterium xenopi KW - Immunosuppressive agents KW - Hip KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17713978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Infectious+Diseases&rft.atitle=Recurrent+Mycobacterium+xenopi+Infection+in+a+Patient+with+Rheumatoid+Arthritis+Receiving+Etanercept&rft.au=Yim%2C+Kyongwook%3BNazeer%2C+SH%3BKiska%2C+D%3BRose%2C+F+B%3BBrown%2C+D%3BCynamon%2C+M+H&rft.aulast=Yim&rft.aufirst=Kyongwook&rft.date=2004-01-01&rft.volume=36&rft.issue=2&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Infectious+Diseases&rft.issn=00365548&rft_id=info:doi/10.1080%2F00365540310017474 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium xenopi; etanercept; Hip; Rheumatoid arthritis; Immunosuppressive agents DO - http://dx.doi.org/10.1080/00365540310017474 ER - TY - JOUR T1 - In Vitro Susceptibility of Nocardia Species to Cethromycin, Clarithromycin and Amikacin AN - 17650648; 6492027 JF - European Journal of Clinical Microbiology & Infectious Diseases AU - Alvirez-Freites, E AU - Yeo, AET AU - DeStefano AU - Cynamon, M H AD - Department of Medicine, Veterans Affairs Medical Center, 800 Irving Avenue, Syracuse, NY 13210, USA, Michael.Cynamon@med.va.gov Y1 - 2004/01// PY - 2004 DA - Jan 2004 SP - 69 EP - 70 VL - 23 IS - 1 SN - 0934-9723, 0934-9723 KW - Cethromycin KW - Microbiology Abstracts B: Bacteriology KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17650648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.atitle=In+Vitro+Susceptibility+of+Nocardia+Species+to+Cethromycin%2C+Clarithromycin+and+Amikacin&rft.au=Alvirez-Freites%2C+E%3BYeo%2C+AET%3BDeStefano%3BCynamon%2C+M+H&rft.aulast=Alvirez-Freites&rft.aufirst=E&rft.date=2004-01-01&rft.volume=23&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.issn=09349723&rft_id=info:doi/10.1007%2Fs10096-003-1054-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-12-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1007/s10096-003-1054-8 ER - TY - JOUR T1 - Understanding Resistance to beta -Lactams and beta -Lactamase Inhibitors in the SHV beta -Lactamase: Lessons from the mutagenesis of SER-130 AN - 19227326; 5788001 AB - Bacterial resistance to beta -lactam/ beta -lactamase inhibitor combinations by single amino acid mutations in class A beta -lactamases threatens our most potent clinical antibiotics. In TEM-1 and SHV-1, the common class A beta -lactamases, alterations at Ser-130 confer resistance to inactivation by the beta -lactamase inhibitors, clavulanic acid, and tazobactam. By using site-saturation mutagenesis, we sought to determine the amino acid substitutions at Ser-130 in SHV-1 beta -lactamase that result in resistance to these inhibitors. Antibiotic susceptibility testing revealed that ampicillin and ampicillin/clavulanic acid resistance was observed only for the S130G beta -lactamase expressed in Escherichia coli. Kinetic analysis of the S130G beta -lactamase demonstrated a significant elevation in apparent K sub(m) and a reduction in k sub(cat)/K sub(m) for ampicillin. Marked increases in the dissociation constant for the preacylation complex, K sub(I), of clavulanic acid (SHV-1, 0.14 mu M; S130G, 46.5 mu M) and tazobactam (SHV-1, 0.07 mu M; S130G, 4.2 mu M) were observed. In contrast, the k sub(inact)s of S130G and SHV-1 differed by only 17% for clavulanic acid and 40% for tazobactam. Progressive inactivation studies showed that the inhibitor to enzyme ratios required to inactivate SHV-1 and S130G were similar. Our observations demonstrate that enzymatic activity is preserved despite amino acid substitutions that significantly alter the apparent affinity of the active site for beta -lactams and beta -lactamase inhibitors. These results underscore the mechanistic versatility of class A beta -lactamases and have implications for the design of novel beta -lactamase inhibitors. JF - Journal of Biological Chemistry AU - Helfand AU - Bethel, C R AU - Hujer, AM AU - Hujer, K M AU - Anderson, V E AU - Bonomo, R A AD - Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, and Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, robert.bonomo@med.va.gov Y1 - 2003/12/26/ PY - 2003 DA - 2003 Dec 26 SP - 52724 EP - 52729 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 278 IS - 52 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Site-directed mutagenesis KW - b-Lactam antibiotics KW - Tazobactam KW - ^b-Lactam antibiotics KW - Clavulanic acid KW - b-Lactamase KW - ^b-Lactamase KW - Antibiotic resistance KW - N 14681:Mutagenesis techniques KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19227326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Understanding+Resistance+to+beta+-Lactams+and+beta+-Lactamase+Inhibitors+in+the+SHV+beta+-Lactamase%3A+Lessons+from+the+mutagenesis+of+SER-130&rft.au=Helfand%3BBethel%2C+C+R%3BHujer%2C+AM%3BHujer%2C+K+M%3BAnderson%2C+V+E%3BBonomo%2C+R+A&rft.aulast=Helfand&rft.aufirst=&rft.date=2003-12-26&rft.volume=278&rft.issue=52&rft.spage=52724&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M306059200 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Antibiotic resistance; b-Lactamase; Tazobactam; Clavulanic acid; Site-directed mutagenesis; b-Lactam antibiotics; ^b-Lactamase; ^b-Lactam antibiotics DO - http://dx.doi.org/10.1074/jbc.M306059200 ER - TY - JOUR T1 - Cbl PYXXM motifs activate the P85 subunit of phosphatidylinositol 3-kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes. AN - 71416185; 14640702 AB - The thiazolidinedione (TZD), rosiglitazone, has previously been found to tyrosine-phosphorylate Cbl and activate Cbl-dependent phosphatidylinositol (PI) 3-kinase and atypical protein kinase Cs (aPKCs) while stimulating glucose transport in 3T3/L1 adipocytes. Presently, the role of Cbl in rosiglitazone action was further assessed in both 3T3/L1 and human adipocytes by expressing Y371F and/or Y731F mutant forms of Cbl that nullified the functionality of canonical pYXXM motifs in Cbl. These mutants diminished the interaction of Cbl with the p85 subunit of PI 3-kinase and inhibited subsequent increases in Cbl-dependent PI 3-kinase activity, aPKC activity, and glucose transport. These mutants also inhibited the interaction of Cbl with Crk, which has been implicated in the activation of other PI 3-kinase-independent signaling factors that have been found to be required during activation of glucose transport by insulin and other agonists. We conclude that pYXXM motifs in Cbl serve to activate PI 3-kinase-dependent and possibly PI 3-kinase-independent pathways that are required for TZD-dependent glucose transport in adipocytes. JF - Biochemistry AU - Miura, Atsushi AU - Sajan, Mini P AU - Standaert, Mary L AU - Bandyopadhyay, Gautam AU - Franklin, Dawn M AU - Lea-Currie, Renee AU - Farese, Robert V AD - Research Service, James A. Haley Veterans Administration Medical Center, and Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA. Y1 - 2003/12/09/ PY - 2003 DA - 2003 Dec 09 SP - 14335 EP - 14341 VL - 42 IS - 48 SN - 0006-2960, 0006-2960 KW - Insulin KW - 0 KW - Isoenzymes KW - Protein Subunits KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins c-crk KW - Thiazolidinediones KW - Deoxyglucose KW - 9G2MP84A8W KW - 2,4-thiazolidinedione KW - AA68LXK93C KW - Proto-Oncogene Proteins c-cbl KW - EC 2.3.2.27 KW - Ubiquitin-Protein Ligases KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - protein kinase C zeta KW - EC 2.7.11.1 KW - PKC-3 protein KW - EC 2.7.11.13 KW - Protein Kinase C KW - protein kinase C lambda KW - CBL protein, human KW - EC 6.3.2.- KW - Cbl protein, mouse KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Animals KW - Deoxyglucose -- antagonists & inhibitors KW - Humans KW - Mice KW - 3T3-L1 Cells KW - Insulin -- pharmacology KW - Protein Subunits -- metabolism KW - Protein Binding KW - Biological Transport -- drug effects KW - Enzyme Activation -- genetics KW - Mutagenesis, Site-Directed KW - Amino Acid Motifs KW - Cells, Cultured KW - Enzyme Activation -- drug effects KW - Deoxyglucose -- metabolism KW - Protein Kinase C -- metabolism KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Adipocytes -- enzymology KW - Thiazolidinediones -- antagonists & inhibitors KW - Glucose -- metabolism KW - Thiazolidinediones -- pharmacology KW - Proto-Oncogene Proteins -- metabolism KW - Adipocytes -- metabolism KW - Proto-Oncogene Proteins -- genetics KW - Proto-Oncogene Proteins -- physiology KW - Phosphatidylinositol 3-Kinases -- antagonists & inhibitors KW - Adipocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71416185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Cbl+PYXXM+motifs+activate+the+P85+subunit+of+phosphatidylinositol+3-kinase%2C+Crk%2C+atypical+protein+kinase+C%2C+and+glucose+transport+during+thiazolidinedione+action+in+3T3%2FL1+and+human+adipocytes.&rft.au=Miura%2C+Atsushi%3BSajan%2C+Mini+P%3BStandaert%2C+Mary+L%3BBandyopadhyay%2C+Gautam%3BFranklin%2C+Dawn+M%3BLea-Currie%2C+Renee%3BFarese%2C+Robert+V&rft.aulast=Miura&rft.aufirst=Atsushi&rft.date=2003-12-09&rft.volume=42&rft.issue=48&rft.spage=14335&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-17 N1 - Date created - 2003-12-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Audiologic manifestations of patients with post-treatment Lyme disease syndrome. AN - 85368662; pmid-14663350 AB - The purpose of this study was to characterize auditory function in patients diagnosed with post-treatment Lyme disease syndrome (PTLDS).Eighteen patients with PTLDS were evaluated and compared to a normal population. Evaluations consisted of pure tone and speech thresholds, word recognition (WRS), acoustic immittance battery, auditory brain stem response (ABR), and loudness discomfort level (LDL). Both seropositive and seronegative patients were evaluated. Audiologists were blinded to patient status.Forty four percent of the patients had one or more abnormal pure tone thresholds compared to gender- and age-adjusted norms. Thirty-one percent showed abnormally reduced LDLs, and 17% had abnormal acoustic reflexes at one or more frequencies.This paper catalogs previously unstudied long-term auditory system sequelae resulting from PTLDS. Our most significant finding was the dramatically reduced loudness tolerance in the presence of either normal or minimally impaired hearing. The clinician is encouraged to consider PTLDS when confronted with these or similar findings in patients having history of Borrelia burgdorferi infection and continued complaints. JF - Ear and hearing AU - Shotland, Lawrence I AU - Mastrioanni, Mary Ann AU - Choo, Daniel L AU - Szymko-Bennett, Yvonne M AU - Dally, Leonard G AU - Pikus, Anita T AU - Sledjeski, Kathryn AU - Marques, Adriana AD - Hearing Section, Neuro-Otology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA. Larry.Shotland@med.va.gov Y1 - 2003/12// PY - 2003 DA - Dec 2003 SP - 508 EP - 517 VL - 24 IS - 6 SN - 0196-0202, 0196-0202 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Audiometry, Pure-Tone KW - Audiometry, Speech KW - *Auditory Perceptual Disorders: etiology KW - Auditory Threshold KW - Chronic Disease KW - Evoked Potentials, Auditory, Brain Stem KW - Female KW - Humans KW - *Loudness Perception KW - *Lyme Disease: complications KW - Lyme Disease: drug therapy KW - Magnetic Resonance Imaging KW - Male KW - Middle Aged UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85368662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear+and+hearing&rft.atitle=Audiologic+manifestations+of+patients+with+post-treatment+Lyme+disease+syndrome.&rft.au=Shotland%2C+Lawrence+I%3BMastrioanni%2C+Mary+Ann%3BChoo%2C+Daniel+L%3BSzymko-Bennett%2C+Yvonne+M%3BDally%2C+Leonard+G%3BPikus%2C+Anita+T%3BSledjeski%2C+Kathryn%3BMarques%2C+Adriana&rft.aulast=Shotland&rft.aufirst=Lawrence&rft.date=2003-12-01&rft.volume=24&rft.issue=6&rft.spage=508&rft.isbn=&rft.btitle=&rft.title=Ear+and+hearing&rft.issn=01960202&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Predicting the outcome of methadone maintenance treatment with the Negative Treatment Indicators content scale from the MMPI-2. AN - 71527870; 14765569 AB - Scores on the Negative Treatment Indicators content scale from the MMPI-2 were not significantly correlated with 5 measures of treatment outcome among 108 male patients on methadone maintenance. These results and those from other studies using this content scale as an independent variable with substance abusers suggest that the scale has yet to demonstrate consistent predictive validity with this population. JF - Psychological reports AU - Craig, Robert J AU - Olson, Ronald E AD - VA Chicago Health Care System, IL, USA. Robert.Craig2@med.va.gov Y1 - 2003/12// PY - 2003 DA - December 2003 SP - 1056 EP - 1058 VL - 93 IS - 3 Pt 2 SN - 0033-2941, 0033-2941 KW - Narcotics KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Humans KW - Outcome Assessment (Health Care) -- methods KW - Treatment Outcome KW - Predictive Value of Tests KW - Middle Aged KW - Male KW - Female KW - Methadone -- therapeutic use KW - MMPI KW - Narcotics -- therapeutic use KW - Narcotics -- administration & dosage KW - Heroin Dependence -- rehabilitation KW - Methadone -- administration & dosage KW - Heroin Dependence -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71527870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+reports&rft.atitle=Predicting+the+outcome+of+methadone+maintenance+treatment+with+the+Negative+Treatment+Indicators+content+scale+from+the+MMPI-2.&rft.au=Craig%2C+Robert+J%3BOlson%2C+Ronald+E&rft.aulast=Craig&rft.aufirst=Robert&rft.date=2003-12-01&rft.volume=93&rft.issue=3+Pt+2&rft.spage=1056&rft.isbn=&rft.btitle=&rft.title=Psychological+reports&rft.issn=00332941&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-09 N1 - Date created - 2004-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Radiation-induced heart disease after Hodgkin's disease and breast cancer treatment: dental implications. AN - 71505776; 14719759 AB - People with Hodgkin's disease and breast cancer often receive therapeutic irradiation to the chest (mediastinum) as an element of treatment. While the therapy often cures the malignancy, it has been implicated in causing late-onset heart disease that may influence the provision of dental treatment. The authors conducted a MEDLINE search of the years 1995 through 2002 using the key terms "Hodgkin's disease," "breast cancer," "radiation therapy," "cardiac valves" and "coronary artery" to define the pathophysiology of the disorder, its epidemiology and dental implications. The articles they selected for further review included those published in English in peer-reviewed journals. Therapeutic irradiation of the chest results in the inadvertent inclusion of the heart within the irradiation field. Over the next 10 to 20 years, some of these people may experience pathological changes of the heart valves that could predispose them to endocarditis, accelerated atherosclerosis of the coronary artery that heightens their risk of experiencing a fatal myocardial infarction or both. Dentists need to identify patients who have received therapeutic irradiation to the chest and consult with the patients' physicians to determine whether the therapy has damaged the heart valves or coronary arteries. Patients with radiation-induced valvular disease may require prophylactic antibiotics when undergoing specific dental procedures that are known to cause a bacteremia and a heightened risk of developing endocarditis. Patients with radiation-induced coronary artery disease should be administered only limited amounts of local anesthetic agents containing a vasoconstrictor, and they may require the administration of sedative agents and cardiac medications to preclude ischemic episodes. JF - Journal of the American Dental Association (1939) AU - Friedlander, Arthur H AU - Sung, Eric C AU - Child, John S AD - VA Greater Los Angeles Healthcare System, Calif. 90073, USA. arthur.friedlander@med.va.gov Y1 - 2003/12// PY - 2003 DA - December 2003 SP - 1615 EP - 1620 VL - 134 IS - 12 SN - 0002-8177, 0002-8177 KW - Dentistry KW - Index Medicus KW - Anesthesia, Dental -- adverse effects KW - Heart Valves -- radiation effects KW - Coronary Vessels -- radiation effects KW - Bacteremia -- prevention & control KW - Bacteremia -- etiology KW - Humans KW - Antibiotic Prophylaxis KW - Female KW - Radiotherapy -- adverse effects KW - Coronary Disease -- etiology KW - Hodgkin Disease -- radiotherapy KW - Endocarditis -- prevention & control KW - Endocarditis -- etiology KW - Heart Valve Diseases -- etiology KW - Breast Neoplasms -- radiotherapy KW - Radiation Injuries -- complications KW - Dental Care for Chronically Ill UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71505776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Radiation-induced+heart+disease+after+Hodgkin%27s+disease+and+breast+cancer+treatment%3A+dental+implications.&rft.au=Friedlander%2C+Arthur+H%3BSung%2C+Eric+C%3BChild%2C+John+S&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2003-12-01&rft.volume=134&rft.issue=12&rft.spage=1615&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-10 N1 - Date created - 2004-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Patterns of substance abuse among treatment-seeking pathological gamblers. AN - 71480435; 14693255 AB - Substance abuse patterns were reviewed for a group of patients admitted to the Gambling Treatment Program at the Brecksville Veterans Administration Medical Center. A retrospective chart review of 113 consecutively admitted patients between September 2000 and September 2001 found that 66.4% of pathological gamblers had a lifetime history of substance abuse or dependence at some point in their lives. A history of substance abuse or dependence was less common among gamblers aged 60 and above. In the year prior to admission, 58.1% of those with a history of substance abuse or dependence were actively using substances. Alcohol was the most commonly used substance, followed by marijuana and cocaine. In most gamblers with comorbid disorders, the onset of substance dependence preceded the onset of problem gambling. Pathological gamblers engaged in multiple impulsive and dysfunctional behaviors including suicide attempts, compulsive shopping and spending, and compulsive sexual behavior, and the presence of comorbid substance abuse disorders may influence the degree to which pathological gamblers engage in these additional problematic behaviors. These factors have important implications for treatment and prevention of relapse, as well as for theories of addictions. JF - Journal of substance abuse treatment AU - Kausch, Otto AD - Louis Stokes Veterans Administration Medical Center, Brecksville Division Veterans Addiction Recovery Center (VARC), 10000 Brecksville Rd., Brecksville, Ohio 44141, USA. Otto.Kausch@med.va.gov Y1 - 2003/12// PY - 2003 DA - December 2003 SP - 263 EP - 270 VL - 25 IS - 4 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Suicide, Attempted -- statistics & numerical data KW - Mental Disorders -- epidemiology KW - Humans KW - Adult KW - Retrospective Studies KW - Ohio -- epidemiology KW - Aged KW - Middle Aged KW - Compulsive Behavior -- epidemiology KW - Male KW - Female KW - Comorbidity KW - Gambling -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71480435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Patterns+of+substance+abuse+among+treatment-seeking+pathological+gamblers.&rft.au=Kausch%2C+Otto&rft.aulast=Kausch&rft.aufirst=Otto&rft.date=2003-12-01&rft.volume=25&rft.issue=4&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-22 N1 - Date created - 2003-12-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association between sweet preference and paternal history of alcoholism in psychiatric and substance abuse patients. AN - 71476364; 14691380 AB - The relationship between preference for stronger sweet solutions and propensity to excessive alcohol drinking is supported by both animal and human studies. This study was designed to test the hypothesis that sweet preference is associated with the genetic risk of alcoholism as measured by a paternal history of alcoholism. Participants were 180 patients admitted to a residential treatment program for the treatment of alcoholism, drug dependence, or psychiatric conditions. In addition to a routine medical examination, patients completed the standard sweet preference test twice (on the 9th and 24th days after admission), and the family history of alcoholism was evaluated. Sweet preference was shown to be stable over time. It was strongly associated with a paternal history of alcoholism, with family history-positive patients approximately 5 times more likely to prefer stronger sweet solutions than family history-negative subjects. Such factors as dependence on alcohol, cocaine, opiates, cannabis, other drugs (including prescription drugs), and tobacco smoking, as well as demographics (gender and age), did not significantly interfere with association between sweet preference and paternal history of alcoholism. These findings provide some support for the hypothesis that preference for stronger sweet solutions is associated with a genetic predisposition to alcoholism as measured by a paternal history of alcoholism. JF - Alcoholism, clinical and experimental research AU - Kampov-Polevoy, A B AU - Ziedonis, D AU - Steinberg, M L AU - Pinsky, I AU - Krejci, J AU - Eick, C AU - Boland, G AU - Khalitov, E AU - Crews, F T AD - Mount Sinai School of Medicine, Division of Psychiatry, Bronx Veterans Affairs Medical Center, New York 10468, USA. alexei.kampov@med.va.gov Y1 - 2003/12// PY - 2003 DA - December 2003 SP - 1929 EP - 1936 VL - 27 IS - 12 SN - 0145-6008, 0145-6008 KW - Sucrose KW - 57-50-1 KW - Index Medicus KW - Taste -- genetics KW - Logistic Models KW - Dose-Response Relationship, Drug KW - Humans KW - Chi-Square Distribution KW - Adult KW - Middle Aged KW - Taste -- drug effects KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- genetics KW - Male KW - Female KW - Mental Disorders -- genetics KW - Food Preferences -- psychology KW - Fathers -- psychology KW - Mental Disorders -- psychology KW - Food Preferences -- physiology KW - Sucrose -- administration & dosage KW - Alcoholism -- genetics KW - Alcoholism -- psychology KW - Food Preferences -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71476364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Association+between+sweet+preference+and+paternal+history+of+alcoholism+in+psychiatric+and+substance+abuse+patients.&rft.au=Kampov-Polevoy%2C+A+B%3BZiedonis%2C+D%3BSteinberg%2C+M+L%3BPinsky%2C+I%3BKrejci%2C+J%3BEick%2C+C%3BBoland%2C+G%3BKhalitov%2C+E%3BCrews%2C+F+T&rft.aulast=Kampov-Polevoy&rft.aufirst=A&rft.date=2003-12-01&rft.volume=27&rft.issue=12&rft.spage=1929&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-13 N1 - Date created - 2003-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The TWEAK is weak for alcohol screening among female Veterans Affairs outpatients. AN - 71474860; 14691385 AB - The optimal brief questionnaire for alcohol screening among female patients has not yet been identified. This study compared the performance of the TWEAK (tolerance, worried, eye-opener, amnesia, cutdown), the Alcohol Use Disorders Identification Test (AUDIT), and the AUDIT Consumption (AUDIT-C) as self-administered screening tests for hazardous drinking and/or active alcohol abuse or dependence among female Veterans Affairs (VA) outpatients. Women were included in the study if they received care at VA Puget Sound and completed both a self-administered survey containing the AUDIT and TWEAK screening questionnaires and subsequent in-person interviews with the Alcohol Use Disorders and Associated Disabilities Interview Schedule. Sensitivities, specificities, positive and negative likelihood ratios, and areas under Receiver Operating Characteristic curves were computed for each screening questionnaire compared with two interview-based comparison standards: (1) active DSM-IV alcohol abuse or dependence and (2) hazardous drinking and/or active DSM-IV alcohol abuse or dependence, the more appropriate target for primary care screening. Of 393 women who completed screening questionnaires and interviews, 39 (9.9%) met diagnostic criteria for alcohol abuse or dependence, and 89 (22.7%) met criteria for hazardous drinking or alcohol abuse or dependence. The TWEAK had relatively low sensitivities (0.62 and 0.44) but adequate specificities (0.86 and 0.89) for both interview-based comparison standards, even at its lowest cut-point (>/=1). The AUDIT and AUDIT-C were superior, with the following areas under the receiver operating characteristic curve for active alcohol abuse or dependence and hazardous drinking and/or active alcohol abuse or dependence, respectively: AUDIT, 0.90 [95% confidence interval (CI), 0.85-0.95] and 0.87 (95% CI, 0.84-0.91); AUDIT-C, 0.91 (95% CI, 0.88-0.95) and 0.91 (95% CI, 0.88-0.94); and TWEAK, 0.76 (95% CI, 0.66-0.86) and 0.67 (95% CI, 0.60-0.74). The TWEAK has low sensitivity as an alcohol-screening questionnaire among female VA outpatients and should be evaluated further before being used in other female primary care populations. The three-item AUDIT-C was the optimal brief alcohol-screening questionnaire in this study. JF - Alcoholism, clinical and experimental research AU - Bush, Kristen R AU - Kivlahan, Daniel R AU - Davis, Tania M AU - Dobie, Dorcas J AU - Sporleder, Jennifer L AU - Epler, Amee J AU - Bradley, Katharine A AD - Department of Veterans Affairs, Veterans Health Administration, Veterans Affairs Puget Sound Health Care System, Center of Excellence in Substance Abuse Treatment and Education, Seattle, WA 98108, USA. kristen.bush@med.va.gov Y1 - 2003/12// PY - 2003 DA - December 2003 SP - 1971 EP - 1978 VL - 27 IS - 12 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - United States KW - Women's Health KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Confidence Intervals KW - Middle Aged KW - Female KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Health Surveys KW - Veterans -- psychology KW - Ambulatory Care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71474860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=The+TWEAK+is+weak+for+alcohol+screening+among+female+Veterans+Affairs+outpatients.&rft.au=Bush%2C+Kristen+R%3BKivlahan%2C+Daniel+R%3BDavis%2C+Tania+M%3BDobie%2C+Dorcas+J%3BSporleder%2C+Jennifer+L%3BEpler%2C+Amee+J%3BBradley%2C+Katharine+A&rft.aulast=Bush&rft.aufirst=Kristen&rft.date=2003-12-01&rft.volume=27&rft.issue=12&rft.spage=1971&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-13 N1 - Date created - 2003-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Distal risk factors for suicidal behavior in alcoholics: replications and new findings. AN - 71401277; 14612227 AB - To examine distal risk factors for suicidal behavior in alcoholics. Two-hundred and eighty alcoholics were interviewed and completed the Childhood Trauma (CTQ) and Eysenck Personality Questionnaires (EPQ). One-hundred and twenty-one of the two-hundred and eighty alcoholics had attempted suicide (42.9%). Significantly more of the attempters were female and had a family history of suicidal behavior. Alcoholics who had attempted were significantly younger and had significantly higher CTQ scores for emotional abuse, physical abuse, sexual abuse, emotional neglect and physical neglect. Attempters were significantly more introverted and neurotic on the EPQ. Significantly more alcoholics who had attempted suicide had received antidepressant medication. Other possible distal and proximal suicide risk factors were not examined. These results suggest that the suicide risk factor model may be applicable to suicidal behavior in alcoholics. Distal risk factors like childhood trauma, family history of suicide, and introversion may increase an alcoholics suicide risk when they experience a proximal or trigger factor like depression. JF - Journal of affective disorders AU - Roy, Alec AD - Psychiatry Service 116A, Department of Veterans Affairs New Jersey Healthcare System, 385 Tremont Avenue,East Orange, NJ 07018, USA. alec.roy@med.va.gov Y1 - 2003/12// PY - 2003 DA - December 2003 SP - 267 EP - 271 VL - 77 IS - 3 SN - 0165-0327, 0165-0327 KW - Index Medicus KW - Emotions KW - Age Factors KW - Humans KW - Personality KW - Personality Inventory KW - Child KW - Introversion (Psychology) KW - Medical History Taking KW - Risk Factors KW - Adult KW - Middle Aged KW - Family Health KW - Female KW - Male KW - Suicide, Attempted -- psychology KW - Child Abuse KW - Alcoholism -- psychology KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71401277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+affective+disorders&rft.atitle=Distal+risk+factors+for+suicidal+behavior+in+alcoholics%3A+replications+and+new+findings.&rft.au=Roy%2C+Alec&rft.aulast=Roy&rft.aufirst=Alec&rft.date=2003-12-01&rft.volume=77&rft.issue=3&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Journal+of+affective+disorders&rft.issn=01650327&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-09 N1 - Date created - 2003-11-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of antigenic heterogeneity on the efficacy of enhanced delivery of antibody-targeted chemotherapy in a human lung cancer intracerebral xenograft model in rats. AN - 71399659; 14633307 AB - The SGN-15 monoclonal antibody-doxorubicin immunoconjugate is toxic to Lewis(Y) antigen-expressing cells and is effective against intracerebral tumors in nude rats when delivery is enhanced with osmotic disruption of the blood-brain barrier (BBB). We tested whether doxorubicin released locally in antigen-expressing cells would affect adjacent non-antigen-expressing cells in heterogeneously expressing intracerebral tumors. Nude rats with intracerebral xenografts of human small cell lung carcinoma cells with high (n = 10) or low (n = 23) Lewis(Y) antigen expression were treated with SGN-15 at a low (10 mg/kg) or high (140 mg/kg) antibody dose, administered intra-arterially with BBB disruption, and tumor volumes and antigen expression were evaluated after 6 days. BBB disruption-enhanced delivery of SGN-15 (10 mg/kg) reduced the high-expressor tumor volume from 26.1 +/- 3.7 mm(3) (n = 7) in untreated control animals to 6.7 +/- 4.6 mm(3) (n = 3, P < 0.05). Untreated high-expressor tumors exhibited uniform prominent Lewis(Y) antigen staining (97.6 +/- 0.9% positive, n = 4), whereas treated tumors demonstrated areas of nil, moderate, and prominent staining (71.0 +/- 8.5% positive, n = 3, P < 0.05). In intracerebral tumors with low initial antigen expression, BBB disruption-enhanced delivery of a low dose of immunoconjugate was significantly effective, but treated tumors demonstrated low levels of antigen expression. An increase in the immunoconjugate dose did not significantly alter either efficacy or antigen expression. Immunoconjugate delivered across the BBB was effective against antigen-positive tumor cells, but there was not an effective chemical bystander effect against antigen-negative tumor cells. JF - Neurosurgery AU - Muldoon, Leslie L AD - Department of Neurology, Oregon Health & Science University, and Veterans Administration Medical Center, Portland, Oregon 97201, USA. neuwelte@ohsu.edu Y1 - 2003/12// PY - 2003 DA - December 2003 SP - 1406 EP - 12; discussion 1412-3 VL - 53 IS - 6 SN - 0148-396X, 0148-396X KW - Antibodies, Monoclonal KW - 0 KW - Antigens, Heterophile KW - BR96-doxorubicin immunoconjugate KW - Lewis Blood-Group System KW - Lewis Y antigen KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Rats KW - Animals KW - Rats, Nude KW - Humans KW - Xenograft Model Antitumor Assays KW - Disease Models, Animal KW - Cell Line, Tumor KW - Female KW - Lewis Blood-Group System -- immunology KW - Brain Neoplasms -- drug therapy KW - Brain Neoplasms -- immunology KW - Doxorubicin -- administration & dosage KW - Antigens, Heterophile -- immunology KW - Carcinoma, Small Cell -- drug therapy KW - Carcinoma, Small Cell -- immunology KW - Antibodies, Monoclonal -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71399659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurosurgery&rft.atitle=Effect+of+antigenic+heterogeneity+on+the+efficacy+of+enhanced+delivery+of+antibody-targeted+chemotherapy+in+a+human+lung+cancer+intracerebral+xenograft+model+in+rats.&rft.au=Muldoon%2C+Leslie+L&rft.aulast=Muldoon&rft.aufirst=Leslie&rft.date=2003-12-01&rft.volume=53&rft.issue=6&rft.spage=1406&rft.isbn=&rft.btitle=&rft.title=Neurosurgery&rft.issn=0148396X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-24 N1 - Date created - 2003-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modafinil for remitted bipolar depression with hypersomnia. AN - 71391828; 14632587 AB - To report 2 cases of bipolar disorder with recent depression in remission with prominent residual hypersomnia, responding well to the addition of the psychostimulant modafinil. Two patients with bipolar disorder with recent depressive episodes in remission are presented. Despite the absence of prominent depressive symptoms, both patients had significant hypersomnia, with scores ranging from 15 to 20 (maximum 24) on the Epworth Sleepiness Scale. The addition of modafinil to their medication regimen resulted in a decrease in hypersomnia and improvement in their level of functioning. This is the first report (MEDLINE search, October 7, 2003) demonstrating the use of modafinil in the treatment of hypersomnia in bipolar disorder while mood symptoms were in remission. Hypersomnia frequently occurs in depressive episodes and can be disabling when severe. The patients had optimal mood stabilization with mood stabilizers and antidepressants, but continued to experience excessive daytime sleepiness. Conventional stimulants were not considered because of the risk of triggering mania. The addition of the selective psychostimulant modafinil resulted in significant improvement in the hypersomnia, with improvement in functioning. No adverse effects or mood changes were noted. Modafinil may be a well-tolerated and effective alternative to conventional stimulants in the treatment of hypersomnia, especially in bipolar disorder, where there is considerable risk of switch to mania with stimulant medications. Modafinil may be useful even when depressive symptoms are not prominent. JF - The Annals of pharmacotherapy AU - Fernandes, Praveen P AU - Petty, Frederick AD - Omaha Veterans Affairs Medical Center and Creighton University School of Medicine, Omaha, NE. Praveen.Fernandes@med.va.gov Y1 - 2003/12// PY - 2003 DA - December 2003 SP - 1807 EP - 1809 VL - 37 IS - 12 SN - 1060-0280, 1060-0280 KW - Benzhydryl Compounds KW - 0 KW - modafinil KW - R3UK8X3U3D KW - Index Medicus KW - Humans KW - Middle Aged KW - Male KW - Female KW - Disorders of Excessive Somnolence -- drug therapy KW - Disorders of Excessive Somnolence -- psychology KW - Disorders of Excessive Somnolence -- complications KW - Benzhydryl Compounds -- therapeutic use KW - Bipolar Disorder -- drug therapy KW - Bipolar Disorder -- psychology KW - Benzhydryl Compounds -- adverse effects KW - Bipolar Disorder -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71391828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Modafinil+for+remitted+bipolar+depression+with+hypersomnia.&rft.au=Fernandes%2C+Praveen+P%3BPetty%2C+Frederick&rft.aulast=Fernandes&rft.aufirst=Praveen&rft.date=2003-12-01&rft.volume=37&rft.issue=12&rft.spage=1807&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-13 N1 - Date created - 2003-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Factors influencing body composition in persons with spinal cord injury: a cross-sectional study AN - 19240901; 5806986 AB - To determine the body composition differences across age, 133 men with chronic spinal cord injury (SCI) (66 with tetraplegia, 67 with paraplegia) were compared with an age-, height-, and ethnicity-matched able-bodied male reference population (n = 100) using two different dual-energy X-ray absorptiometry densitometers. The effects of duration of injury, level, and completeness of lesion were analyzed in the SCI population. Independent of age, total body and regional lean mass were lower and fat mass was higher in persons with SCI compared with controls. The SCI group was 13 plus or minus 1% (means plus or minus SE) fatter per unit of body mass index (kg/m super(2)) compared with the control group (P < 0.0001). Advancing age was strongly associated with less lean mass and greater adiposity in those with SCI, whereas it was mildly related in the controls. Total body and regional arm and trunk, but not leg, lean tissues were lower in subjects with SCI, across all ages, than in the controls. In summary, persons with SCI were fatter for any body mass index and demonstrated significantly less lean and more adipose tissues for any given age compared with controls. JF - Journal of Applied Physiology AU - Spungen, A M AU - Adkins, R H AU - Stewart, CA AU - Wang, J AU - Pierson, RN Jr AU - Waters, R L AU - Bauman, WA AD - Spinal Cord Damage Research Center, VA Medical Center, Rm. 1E-02, 130 West Kingsbridge Road, Bronx, NY 10468, USA, ann.spungen@med.va.gov Y1 - 2003/12// PY - 2003 DA - Dec 2003 SP - 2398 EP - 2407 VL - 95 IS - 6 SN - 8750-7587, 8750-7587 KW - Physical Education Index KW - X-Ray KW - Age KW - Spine KW - Body composition KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19240901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Physiology&rft.atitle=Factors+influencing+body+composition+in+persons+with+spinal+cord+injury%3A+a+cross-sectional+study&rft.au=Spungen%2C+A+M%3BAdkins%2C+R+H%3BStewart%2C+CA%3BWang%2C+J%3BPierson%2C+RN+Jr%3BWaters%2C+R+L%3BBauman%2C+WA&rft.aulast=Spungen&rft.aufirst=A&rft.date=2003-12-01&rft.volume=95&rft.issue=6&rft.spage=2398&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Physiology&rft.issn=87507587&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Body composition; X-Ray; Spine; Age ER - TY - JOUR T1 - Asynchronous Functional, Cellular and Transcriptional Changes after a Bout of Eccentric Exercise in the Rat AN - 1780521329; PQ0002847901 AB - Thirty eccentric contractions (ECs) were imposed upon rat dorsiflexors ( n= 46 ) by activating the peroneal nerve and plantarflexing the foot approximately 40 deg, corresponding to a sarcomere length change over the range 2.27-2.39 mu m for the tibialis anterior and 2.52-2.66 mu m for the extensor digitorum longus. Animals were allowed to recover for one of 10 time periods ranging from 0.5 to 240 h, at which time muscle contractile properties, immunohistochemical labelling and gene expression were measured. Peak isometric torque dropped significantly by approximately 40 % from an initial level of 0.0530 plus or minus 0.0009 Nm to 0.0298 plus or minus 0.0008 Nm ( P < 0.0001 ) immediately after EC, and then recovered in a linear fashion to control levels 168 h later. Immunohistochemical labelling of cellular proteins revealed a generally asynchronous sequence of events at the cellular level, with the earliest event measured being loss of immunostaining for the intermediate filament protein, desmin. Soon after the first signs of desmin loss, infiltration of inflammatory cells occurred, followed by a transient increase in membrane permeability, manifested as inclusion of plasma fibronectin. The quantitative polymerase chain reaction (QPCR) was used to measure transcript levels of desmin, vimentin, embryonic myosin heavy chain (MHC), myostatin, myoD and myogenin. Compared to control levels, myostatin transcripts were significantly elevated after only 0.5 h, myogenic regulatory factors significantly elevated after 3 h and desmin transcripts were significantly increased 12 h after EC. None of the measured parameters provide a mechanistic explanation for muscle force loss after EC. Future studies are required to investigate whether there is a causal relationship among desmin loss, increased cellular permeability, upregulation of the myoD and desmin genes, and, ultimately, an increase in the desmin content per sarcomere of the muscle. JF - Journal of Physiology (London) AU - Peters, David AU - Barash, Ilona A AU - Burdi, Michael AU - Yuan, Philip S AU - Mathew, Liby AU - Friden, Jan AU - Lieber, Richard L AD - Departments of Orthopaedics and Bioengineering, and the Biomedical Sciences Graduate Group University of California and Veterans Administration Medical Centers, San Diego, CA, USA. Y1 - 2003/12// PY - 2003 DA - December 2003 SP - 947 EP - 957 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 553 IS - 3 SN - 0022-3751, 0022-3751 KW - Physical Education Index KW - Force KW - Measurement KW - Blood KW - Exercise physiology KW - Feet KW - Muscles KW - Proteins KW - Isometrics KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780521329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Physiology+%28London%29&rft.atitle=Asynchronous+Functional%2C+Cellular+and+Transcriptional+Changes+after+a+Bout+of+Eccentric+Exercise+in+the+Rat&rft.au=Peters%2C+David%3BBarash%2C+Ilona+A%3BBurdi%2C+Michael%3BYuan%2C+Philip+S%3BMathew%2C+Liby%3BFriden%2C+Jan%3BLieber%2C+Richard+L&rft.aulast=Peters&rft.aufirst=David&rft.date=2003-12-01&rft.volume=553&rft.issue=3&rft.spage=947&rft.isbn=&rft.btitle=&rft.title=Journal+of+Physiology+%28London%29&rft.issn=00223751&rft_id=info:doi/10.1113%2Fjphysiol.2003.048462 LA - English DB - Physical Education Index N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Force; Blood; Measurement; Exercise physiology; Feet; Muscles; Isometrics; Proteins DO - http://dx.doi.org/10.1113/jphysiol.2003.048462 ER - TY - JOUR T1 - Cellular Vacuolation and Mitochondrial Cytochrome c Release Are Independent Outcomes of Helicobacter pylori Vacuolating Cytotoxin Activity That Are Each Dependent on Membrane Channel Formation AN - 19197349; 5770008 AB - Helicobacter pylori vacuolating toxin (VacA) is a secreted toxin that is reported to produce multiple effects on mammalian cells. In this study, we explored the relationship between VacA-induced cellular vacuolation and VacA- induced cytochrome c release from mitochondria. Within intoxicated cells, vacuolation precedes cytochrome c release and occurs at lower VacA concentrations, indicating that cellular vacuolation is not a downstream consequence of cytochrome c release. Conversely, bafilomycin A1 blocks VacA- induced vacuolation but not VacA-induced cytochrome c release, which indicates that cytochrome c release is not a downstream consequence of cellular vacuolation. Acid activation of purified VacA is required for entry of VacA into cells, and correspondingly, acid activation of the toxin is required for both vacuolation and cytochrome c release, which suggests that VacA must enter cells to produce these two effects. Single amino acid substitutions (P9A and G14A) that ablate vacuolating activity and membrane channel-forming activity render VacA unable to induce cytochrome c release. Channel blockers known to inhibit cellular vacuolation and VacA membrane channel activity also inhibit cytochrome c release. These data indicate that cellular vacuolation and mitochondrial cytochrome c release are two independent outcomes of VacA intoxication and that both effects are dependent on the formation of anion-selective membrane channels. JF - Journal of Biological Chemistry AU - Willhite, D C AU - Cover, T L AU - Blanke AD - Department of Biology and Biochemistry, University of Houston, 369 Science & Research Building II, Houston, Texas 77204-5001 and Departments of Medicine and Microbiology and Immunology, Vanderbilt University School of Medicine and Veterans Administration Medical Center, Nashville, Tennessee 37232-2605, sblanke@uh.edu Y1 - 2003/11/28/ PY - 2003 DA - 2003 Nov 28 SP - 48204 EP - 48209 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 278 IS - 48 SN - 0021-9258, 0021-9258 KW - bafilomycin A1 KW - Microbiology Abstracts B: Bacteriology KW - Helicobacter pylori KW - Cytochrome c KW - Gastrointestinal tract diseases KW - Cytotoxins KW - Vacuoles KW - Mitochondria KW - Mutation KW - VacA protein KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19197349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Cellular+Vacuolation+and+Mitochondrial+Cytochrome+c+Release+Are+Independent+Outcomes+of+Helicobacter+pylori+Vacuolating+Cytotoxin+Activity+That+Are+Each+Dependent+on+Membrane+Channel+Formation&rft.au=Willhite%2C+D+C%3BCover%2C+T+L%3BBlanke&rft.aulast=Willhite&rft.aufirst=D&rft.date=2003-11-28&rft.volume=278&rft.issue=48&rft.spage=48204&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M304131200 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Helicobacter pylori; Cytotoxins; Vacuoles; Mitochondria; Cytochrome c; VacA protein; Gastrointestinal tract diseases; Mutation DO - http://dx.doi.org/10.1074/jbc.M304131200 ER - TY - JOUR T1 - Suggested guidelines for evaluation and treatment of glucocorticoid-induced osteoporosis for the Department of Veterans Affairs. AN - 71406467; 14638562 AB - Glucocorticoid-induced osteoporosis is an important disorder in the predominantly male US veteran population. Department of Veterans Affairs facilities vary considerably in evaluation and management of glucocorticoid-induced osteoporosis. We suggest how evaluation and management can take place in medical centers with and without bone mineral density measurements by dual energy x-ray absorptiometry (DXA). The proposed guidelines can be applied to other health care systems. Use of DXA can help determine fracture risk for patients taking glucocorticoid therapy and for those starting therapy for at least 3 months. Patients with low bone mineral density should be treated with a bisphosponate as should all patients about to start prednisone treatment at a dose of 7.5 mg/d or more. In facilities without DXA, most patients should be treated with bisphosphonates, the cost of which is about $30 to $35 per month. In addition, the use of urinary calcium measurements is encouraged to determine which patients might benefit from augmented vitamin D and calcium supplementation. Attention to fracture risk assessment in patients undergoing glucocorticoid therapy and timely bisphosphonate treatment should lead to fewer fractures. JF - Archives of internal medicine AU - Adler, Robert A AU - Hochberg, Marc C AD - Endocrinology Section (111-P), McGuire Veterans Affairs Medical Center, Richmond, VA 23249, USA. robert.adler@med.va.gov Y1 - 2003/11/24/ PY - 2003 DA - 2003 Nov 24 SP - 2619 EP - 2624 VL - 163 IS - 21 SN - 0003-9926, 0003-9926 KW - Diphosphonates KW - 0 KW - Glucocorticoids KW - Parathyroid Hormone KW - Calcium KW - SY7Q814VUP KW - Prednisone KW - VB0R961HZT KW - Abridged Index Medicus KW - Index Medicus KW - Sarcoidosis -- complications KW - Humans KW - Absorptiometry, Photon KW - Parathyroid Hormone -- therapeutic use KW - Calcium -- urine KW - Veterans KW - Fractures, Bone -- prevention & control KW - Diphosphonates -- therapeutic use KW - Prednisone -- adverse effects KW - Fractures, Bone -- etiology KW - Glucocorticoids -- adverse effects KW - Osteoporosis -- economics KW - Osteoporosis -- therapy KW - Osteoporosis -- complications KW - Osteoporosis -- chemically induced KW - Diphosphonates -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71406467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Suggested+guidelines+for+evaluation+and+treatment+of+glucocorticoid-induced+osteoporosis+for+the+Department+of+Veterans+Affairs.&rft.au=Adler%2C+Robert+A%3BHochberg%2C+Marc+C&rft.aulast=Adler&rft.aufirst=Robert&rft.date=2003-11-24&rft.volume=163&rft.issue=21&rft.spage=2619&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-12-23 N1 - Date created - 2003-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sodium butyrate inhibits angiogenesis of human intestinal microvascular endothelial cells through COX-2 inhibition. AN - 71335425; 14596920 AB - We examined the effect of sodium butyrate on in vitro angiogenesis and cyclooxygenase (COX) expression using primary cultures of human intestinal microvascular endothelial cells (HIMEC). Butyrate inhibited VEGF-induced cellular proliferation, transmigration and tube formation of HIMEC. Butyrate also inhibited COX-2 expression as well as prostaglandin (PG)E2 and PGI2 production, and administration of PGI2 analog partially reversed the effect of butyrate on HIMEC angiogenesis. These results indicate that sodium butyrate inhibits HIMEC angiogenesis through down-regulation of COX-2 expression and PG production, and suggest that anti-angiogenic mechanisms may also be involved in the inhibitory effect of sodium butyrate on tumor growth. JF - FEBS letters AU - Ogawa, Hitoshi AU - Rafiee, Parvaneh AU - Fisher, Pamela J AU - Johnson, Nathan A AU - Otterson, Mary F AU - Binion, David G AD - Department of Medicine, Division of Gastroenterology and Hepatology, Digestive Disease Center, Froedtert Memorial Lutheran Hospital, Milwaukee Veterans Administration Medical Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Y1 - 2003/11/06/ PY - 2003 DA - 2003 Nov 06 SP - 88 EP - 94 VL - 554 IS - 1-2 SN - 0014-5793, 0014-5793 KW - Angiogenesis Inhibitors KW - 0 KW - Butyrates KW - Cyclooxygenase 2 Inhibitors KW - Cyclooxygenase Inhibitors KW - Isoenzymes KW - Membrane Proteins KW - Vascular Endothelial Growth Factor A KW - Epoprostenol KW - DCR9Z582X0 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Dinoprostone -- biosynthesis KW - Humans KW - Cell Division -- drug effects KW - Vascular Endothelial Growth Factor A -- pharmacology KW - Cyclooxygenase Inhibitors -- pharmacology KW - Prostaglandin-Endoperoxide Synthases -- physiology KW - Isoenzymes -- physiology KW - Isoenzymes -- biosynthesis KW - Cell Movement -- drug effects KW - Microcirculation KW - Drug Antagonism KW - Epoprostenol -- biosynthesis KW - Prostaglandin-Endoperoxide Synthases -- biosynthesis KW - Angiogenesis Inhibitors -- pharmacology KW - Endothelium, Vascular -- drug effects KW - Endothelium, Vascular -- cytology KW - Intestines -- blood supply KW - Butyrates -- pharmacology KW - Neovascularization, Physiologic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71335425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Sodium+butyrate+inhibits+angiogenesis+of+human+intestinal+microvascular+endothelial+cells+through+COX-2+inhibition.&rft.au=Ogawa%2C+Hitoshi%3BRafiee%2C+Parvaneh%3BFisher%2C+Pamela+J%3BJohnson%2C+Nathan+A%3BOtterson%2C+Mary+F%3BBinion%2C+David+G&rft.aulast=Ogawa&rft.aufirst=Hitoshi&rft.date=2003-11-06&rft.volume=554&rft.issue=1-2&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-12-23 N1 - Date created - 2003-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of a speech-in-multitalker-babble paradigm to assess word-recognition performance. AN - 85415269; pmid-14708835 AB - A simple word-recognition task in multitalker babble for clinic use was developed in the course of four experiments involving listeners with normal hearing and listeners with hearing loss. In Experiments 1 and 2, psychometric functions for the individual NU No. 6 words from Lists 2, 3, and 4 were obtained with each word in a unique segment of multitalker babble. The test paradigm that emerged involved ten words at each of seven signal-to-babble ratios (S/B) from 0 to 24 dB. Experiment 3 examined the effect that babble presentation level (70, 80, and 90 dB SPL) had on recognition performance in babble, whereas Experiment 4 studied the effect that monaural and binaural listening had on recognition performance. For listeners with normal hearing, the 90th percentile was 6 dB S/B. In comparison to the listeners with normal hearing, the 50% correct points on the functions for listeners with hearing loss were at 5 to 15 dB higher signal-to-babble ratios. JF - Journal of the American Academy of Audiology AU - Wilson, Richard H AD - James H. Quillen VA Medical Center, Mountain Home, Tennessee 37684, USA. RICHARD.WILSON2@MED.VA.GOV Y1 - 2003/11// PY - 2003 DA - Nov 2003 SP - 453 EP - 470 VL - 14 IS - 9 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Acoustic Stimulation KW - Adolescent KW - Adult KW - Aged KW - Aged, 80 and over KW - Female KW - *Hearing Loss, High-Frequency: physiopathology KW - Humans KW - Male KW - Middle Aged KW - *Perceptual Masking KW - Psychometrics KW - *Speech Reception Threshold Test: instrumentation KW - *Vocabulary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85415269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Development+of+a+speech-in-multitalker-babble+paradigm+to+assess+word-recognition+performance.&rft.au=Wilson%2C+Richard+H&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2003-11-01&rft.volume=14&rft.issue=9&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Erratum In: J Am Acad Audiol. 2010 Jan;21(1):66 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The effects of click and tone-burst stimulus parameters on the vestibular evoked myogenic potential (VEMP). AN - 85369223; pmid-14708838 AB - Vestibular evoked myogenic potentials (VEMP) are short latency electromyograms (EMG) evoked by high-level acoustic stimuli and recorded from surface electrodes over the tonically contracted sternocleidomastoid (SCM) muscle and are presumed to originate in the saccule. The present experiments examined the effects of click and tone-burst level and stimulus frequency on the latency, amplitude, and threshold of the VEMP in subjects with normal hearing sensitivity and no history of vestibular disease. VEMPs were recorded in all subjects using 100 dB nHL click stimuli. Most subjects had VEMPs present at 500, 750, and 1000 Hz, and few subjects had VEMPs present at 2000 Hz. The response amplitude of the VEMP increased with click and tone-burst level, whereas VEMP latency was not influenced by the stimulus level. The largest tone-burst-evoked VEMPs and lowest thresholds were obtained at 500 and 750 Hz. VEMP latency was independent of stimulus frequency when tone-burst duration was held constant. JF - Journal of the American Academy of Audiology AU - Akin, Faith Wurm AU - Murnane, Owen D AU - Proffitt, Tina M AD - James H. Quillen VA Medical Center, Mountain Home, TN 37684, USA. faith.akin@med.va.gov Y1 - 2003/11// PY - 2003 DA - Nov 2003 SP - 500 EP - 9; quiz 534-5 VL - 14 IS - 9 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - *Acoustic Stimulation: methods KW - Adult KW - Analysis of Variance KW - Auditory Threshold KW - Electromyography KW - *Evoked Potentials, Auditory: physiology KW - Female KW - Humans KW - Male KW - Middle Aged KW - Reaction Time: physiology KW - Saccule and Utricle: physiology KW - Vestibular Function Tests KW - Vestibular Nerve: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85369223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=The+effects+of+click+and+tone-burst+stimulus+parameters+on+the+vestibular+evoked+myogenic+potential+%28VEMP%29.&rft.au=Akin%2C+Faith+Wurm%3BMurnane%2C+Owen+D%3BProffitt%2C+Tina+M&rft.aulast=Akin&rft.aufirst=Faith&rft.date=2003-11-01&rft.volume=14&rft.issue=9&rft.spage=500&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The effects of high-frequency hearing loss on low-frequency components of the click-evoked otoacoustic emission. AN - 85366067; pmid-14708841 AB - Click-evoked otoacoustic emission (CEOAE) input/output (I/O) functions were measured in ears with normal hearing and in ears with sensorineural hearing loss above 2000 Hz. The low- to midfrequency CEOAEs obtained from the ears with high-frequency hearing loss were significantly reduced in level compared to the CEOAEs obtained from the ears with normal hearing even though there were no significant group differences in the 250-2000 Hz pure-tone thresholds. The findings are discussed within the context of two hypotheses that explain the low- to midfrequency reduction in transient-evoked otoacoustic emission (TEOAE) magnitude: (1) subclinical damage to the more apical regions of the cochlea not detected by behavioral audiometry, or (2) trauma to the basal region of the cochlea that affects the generation of low-frequency emissions. It is proposed that localized damage at basal cochlear sites affects the generation of low- to midfrequency CEOAE energy. JF - Journal of the American Academy of Audiology AU - Murnane, Owen D AU - Kelly, John K AD - James H. Quillen VA Medical Center, Mountain Home, Tennessee 37684, USA. owen.murnane@med.va.gov Y1 - 2003/11// PY - 2003 DA - Nov 2003 SP - 525 EP - 533 VL - 14 IS - 9 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Analysis of Variance KW - Auditory Threshold KW - Cochlea: physiopathology KW - Female KW - *Hearing Loss, High-Frequency: physiopathology KW - Humans KW - Male KW - Middle Aged KW - *Otoacoustic Emissions, Spontaneous KW - Pitch Perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85366067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=The+effects+of+high-frequency+hearing+loss+on+low-frequency+components+of+the+click-evoked+otoacoustic+emission.&rft.au=Murnane%2C+Owen+D%3BKelly%2C+John+K&rft.aulast=Murnane&rft.aufirst=Owen&rft.date=2003-11-01&rft.volume=14&rft.issue=9&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Diagnosis and treatment of alcohol dependence in older alcoholics. AN - 71571213; 15024810 AB - Treatment of alcohol dependence among older alcoholic patients should be multidimensional to address as many potential relapse factors as possible. As the literature suggests, alcohol-related disorders often are under diagnosed and under treated. More efforts are needed to identify and improve diagnosis of these disorders in older alcoholic patients. For better outcomes, age-specific programs should be implemented. Furthermore, when treating elderly patients, basic therapeutic principles like respect for privacy and a respectful attitude should be adopted. Adequate medical, pharmacologic, and psychiatric treatment should be provided when appropriate. Medication to reduce cravings should be considered in patients without contraindications to its use. Participation in individual, group, and family therapy and attendance at self-help group meetings such as AA should be encouraged (Table 8). Despite the lack of empiric testing to validate these recommendations in an elderly population, clinical experience suggests that adherence to these recommendations will benefit elderly patients just as it has the general adult population. Research is necessary to explore the benefits of alcohol treatments in elderly patients. Until then, adherence to these recommendations should be the best available approach. JF - Clinics in geriatric medicine AU - Sattar, S Pirzada AU - Petty, Frederick AU - Burke, William J AD - Department of Psychiatry, Creighton University School of Medicine, Omaha Veteran's Administration Medical Center, University of Nebraska School of Medicine, Omaha, NE, USA. syed.sattar@med.va.gov Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 743 EP - 761 VL - 19 IS - 4 SN - 0749-0690, 0749-0690 KW - Index Medicus KW - Alcohol-Related Disorders -- diagnosis KW - Humans KW - Aged KW - Alcohol-Related Disorders -- therapy KW - Alcohol Drinking KW - Alcoholism -- diagnosis KW - Alcoholism -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71571213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+geriatric+medicine&rft.atitle=Diagnosis+and+treatment+of+alcohol+dependence+in+older+alcoholics.&rft.au=Sattar%2C+S+Pirzada%3BPetty%2C+Frederick%3BBurke%2C+William+J&rft.aulast=Sattar&rft.aufirst=S&rft.date=2003-11-01&rft.volume=19&rft.issue=4&rft.spage=743&rft.isbn=&rft.btitle=&rft.title=Clinics+in+geriatric+medicine&rft.issn=07490690&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-13 N1 - Date created - 2004-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Latex allergy. AN - 71474481; 14673247 AB - Allergy to natural rubber latex affects people routinely exposed to rubber products. Groups thought to be at highest risk include atopics, health care workers, rubber industry workers, and individuals who have undergone multiple surgical procedures, especially those with spina bifida. Allergy to latex is a type I, immediate, IgE-mediated reaction that can lead to anaphylaxis and death. The prevalence, risk factors, clinical manifestations, diagnosis, and management of latex allergy are summarized in this review. JF - Skinmed AU - Warshaw, Erin M AD - Minneapolis VA Medical Center and the Department of Dermatology, University of Minnesota, Minneapolis, MN 55417, USA. erin.warshaw@med.va.gov PY - 2003 SP - 359 EP - 366 VL - 2 IS - 6 SN - 1540-9740, 1540-9740 KW - Index Medicus KW - Severity of Illness Index KW - Primary Prevention KW - Survival Rate KW - Risk Factors KW - Humans KW - Prognosis KW - Health Personnel KW - Incidence KW - Patch Tests KW - Male KW - Female KW - Occupational Diseases -- diagnosis KW - Latex Hypersensitivity -- diagnosis KW - Latex Hypersensitivity -- epidemiology KW - Hypersensitivity, Immediate -- drug therapy KW - Occupational Diseases -- etiology KW - Occupational Diseases -- epidemiology KW - Latex Hypersensitivity -- drug therapy KW - Hypersensitivity, Immediate -- epidemiology KW - Hypersensitivity, Immediate -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71474481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Skinmed&rft.atitle=Latex+allergy.&rft.au=Warshaw%2C+Erin+M&rft.aulast=Warshaw&rft.aufirst=Erin&rft.date=2003-11-01&rft.volume=2&rft.issue=6&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Skinmed&rft.issn=15409740&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-22 N1 - Date created - 2003-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characteristics of drug addicts who attempt suicide. AN - 71317071; 14572627 AB - The aim of the study was to further describe the characteristics of drug-dependent patients who attempt suicide. Thus, 449 drug-dependent patients were interviewed about whether or not they had ever attempted suicide and about their family history of suicidal behavior. Patients completed the Childhood Trauma Questionnaire and the Eysenck Personality Questionnaire, and were interviewed with the Addiction Severity Index (ASI). It was found that patients who had attempted suicide (N=175) were significantly younger than patients who had never attempted suicide (N=274). Significantly more of the patients who had attempted suicide were female; had a family history of suicide; and had a lifetime history of major depression, of having received antidepressant medication, and of alcoholism. Also, patients who had attempted suicide had significantly higher scores for childhood trauma, psychoticism, neuroticism and introversion, as well as higher ASI psychiatric composite scores. These results suggest that social, personality, family, developmental and psychiatric risk factors may predispose to suicidal behavior in drug-dependent individuals. JF - Psychiatry research AU - Roy, Alec AD - Psychiatry Service 116A, Department of Veterans Affairs, New Jersey Healthcare System, 385 Tremont Avenue, East Orange, NJ 07018, USA. alec.roy@med.va.gov Y1 - 2003/11/01/ PY - 2003 DA - 2003 Nov 01 SP - 99 EP - 103 VL - 121 IS - 1 SN - 0165-1781, 0165-1781 KW - Index Medicus KW - Child Abuse -- psychology KW - Personality Inventory -- statistics & numerical data KW - Child Abuse -- statistics & numerical data KW - Humans KW - Child of Impaired Parents -- psychology KW - Psychometrics -- statistics & numerical data KW - Child KW - Comorbidity KW - Life Change Events KW - Risk Factors KW - Adult KW - Child of Impaired Parents -- statistics & numerical data KW - Middle Aged KW - Female KW - Male KW - Opioid-Related Disorders -- epidemiology KW - Opioid-Related Disorders -- psychology KW - Alcoholism -- epidemiology KW - Suicide, Attempted -- statistics & numerical data KW - Suicide, Attempted -- psychology KW - Depressive Disorder, Major -- psychology KW - Cocaine-Related Disorders -- psychology KW - Depressive Disorder, Major -- epidemiology KW - Cocaine-Related Disorders -- epidemiology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71317071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Characteristics+of+drug+addicts+who+attempt+suicide.&rft.au=Roy%2C+Alec&rft.aulast=Roy&rft.aufirst=Alec&rft.date=2003-11-01&rft.volume=121&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-21 N1 - Date created - 2003-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Animal and in vitro models of alcoholic pancreatitis: role of cholecystokinin. AN - 71312485; 14576490 AB - Although ethanol abuse is the major etiologic factor in the development of acute and chronic pancreatitis, the mechanisms of ethanol effects to cause pancreatitis are poorly understood. The major reason for the lack of progress is the relative lack of animal models that reproduce the deleterious effects of ethanol on the pancreas that are observed in human disease. We propose that the effect of ethanol on the pancreas is due to its ability to sensitize animals and humans to the potentially injurious effects of other stimuli. We have developed models of ethanol-induced acute and chronic pancreatitis in rats as well as pancreatic acinar cells in primary culture demonstrating that ethanol sensitizes the pancreas to the inflammatory, cell death, and fibrosing responses caused by cholecystokinin (CCK). Our results indicate that the ethanol-sensitized inflammatory response is the key or trigger event for the development of the other pathologic responses in both acute and chronic pancreatitis, such as cell death, intracellular digestive enzyme activation, and fibrosis. These findings suggest that experimental strategies designed to reveal the modulating effects of ethanol on the mechanisms underlying the inflammatory, cell death, and fibrosing responses stimulated by CCK will provide the key information needed to understand how ethanol abuse causes pancreatitis. JF - Pancreas AU - Pandol, Stephen J AU - Gukovsky, Ilya AU - Satoh, Akihiko AU - Lugea, Aurelia AU - Gukovskaya, Anna S AD - Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, California 90073, USA. Stephen.Pandol@med.va.gov Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 297 EP - 300 VL - 27 IS - 4 KW - NF-kappa B KW - 0 KW - Transcription Factor AP-1 KW - Ethanol KW - 3K9958V90M KW - Sincalide KW - M03GIQ7Z6P KW - Index Medicus KW - Rats KW - Pancreas -- pathology KW - Animals KW - Transcription Factor AP-1 -- metabolism KW - Pancreas -- metabolism KW - Humans KW - In Vitro Techniques KW - Ethanol -- administration & dosage KW - Sincalide -- administration & dosage KW - Pancreas -- drug effects KW - NF-kappa B -- metabolism KW - Pancreatitis, Alcoholic -- chemically induced KW - Pancreatitis, Alcoholic -- metabolism KW - Disease Models, Animal KW - Pancreatitis, Alcoholic -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71312485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pancreas&rft.atitle=Animal+and+in+vitro+models+of+alcoholic+pancreatitis%3A+role+of+cholecystokinin.&rft.au=Pandol%2C+Stephen+J%3BGukovsky%2C+Ilya%3BSatoh%2C+Akihiko%3BLugea%2C+Aurelia%3BGukovskaya%2C+Anna+S&rft.aulast=Pandol&rft.aufirst=Stephen&rft.date=2003-11-01&rft.volume=27&rft.issue=4&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Pancreas&rft.issn=1536-4828&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-15 N1 - Date created - 2003-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Docetaxel and ketoconazole in advanced hormone-refractory prostate carcinoma: a phase I and pharmacokinetic study. AN - 71311285; 14584067 AB - Docetaxel has significant single-agent activity in patients with prostate carcinoma, and ketoconazole has activity as a second-line hormonal agent. In vitro, ketoconazole exhibits synergy with several chemotherapeutic agents. A potential drug interaction exists, however, because both docetaxel and ketoconazole are metabolized hepatically by the cytochrome p450 system (CYP3A4). The authors performed a Phase I study and a pharmacokinetic study evaluating the both tolerability of a docetaxel/ketoconazole combination as well as this potential drug interaction. For all initial patients, docetaxel was administered intravenously at a dose of 55 mg/m(2) over 1 hour every 21 days. Starting on Day 8 after their first docetaxel dose, cohorts of at least 3-5 new patients were enrolled to receive escalating doses of ketoconazole. When the maximally tolerated dose (MTD) of ketoconazole was reached, the subsequent cohort of patients received an escalating dose of docetaxel. Pharmacokinetic studies were performed after docetaxel infusions on Day 1 (prior to ketoconazole) and Day 22 (after starting ketoconazole). Twenty-six patients were enrolled and completed at least 2 cycles of treatment. The MTD was ketoconazole 400 mg twice daily and docetaxel 55 mg/m(2). Dose-limiting toxicities included neutropenia and fatigue. Ketoconazole did not cause a consistent effect on docetaxel pharmacokinetics, although there was significant intrapatient and interpatient variability in serum levels. The recommended Phase II dose for this combination is ketoconazole 400 mg twice daily and docetaxel 55 mg/m(2) every 21 days. JF - Cancer AU - Van Veldhuizen, Peter J AU - Reed, Gregory AU - Aggarwal, Arvind AU - Baranda, Joaquina AU - Zulfiqar, Muhammad AU - Williamson, Stephen AD - Department of Medicine, Section of Hematology/Oncology, Kansas City Veterans Affairs Medical Center, University of Kansas Medical Center, Kansas City, Missouri 64128, USA. peter.vandeldhuizen@med.va.gov Y1 - 2003/11/01/ PY - 2003 DA - 2003 Nov 01 SP - 1855 EP - 1862 VL - 98 IS - 9 SN - 0008-543X, 0008-543X KW - Taxoids KW - 0 KW - docetaxel KW - 15H5577CQD KW - Paclitaxel KW - P88XT4IS4D KW - Ketoconazole KW - R9400W927I KW - Abridged Index Medicus KW - Index Medicus KW - Drug Administration Schedule KW - Humans KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Maximum Tolerated Dose KW - Male KW - Paclitaxel -- administration & dosage KW - Ketoconazole -- pharmacokinetics KW - Paclitaxel -- adverse effects KW - Paclitaxel -- pharmacokinetics KW - Paclitaxel -- analogs & derivatives KW - Ketoconazole -- administration & dosage KW - Prostatic Neoplasms -- drug therapy KW - Ketoconazole -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71311285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Docetaxel+and+ketoconazole+in+advanced+hormone-refractory+prostate+carcinoma%3A+a+phase+I+and+pharmacokinetic+study.&rft.au=Van+Veldhuizen%2C+Peter+J%3BReed%2C+Gregory%3BAggarwal%2C+Arvind%3BBaranda%2C+Joaquina%3BZulfiqar%2C+Muhammad%3BWilliamson%2C+Stephen&rft.aulast=Van+Veldhuizen&rft.aufirst=Peter&rft.date=2003-11-01&rft.volume=98&rft.issue=9&rft.spage=1855&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-11-05 N1 - Date created - 2003-10-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Residence near a major road and respiratory symptoms in U.S. Veterans. AN - 71280418; 14569190 AB - There is evidence that exposure to motor vehicle exhaust is associated with respiratory disease. Studies in children have observed associations with wheeze, hospital admissions for asthma, and decrements in pulmonary function. However, a relationship of adult respiratory disease with exposure to vehicular traffic has not been established. We studied a sample of U.S. male veterans drawn from the general population of southeastern Massachusetts. Information on respiratory symptoms and potential risk factors was collected by questionnaire. We assessed distance from residential addresses to major roadways using geographic information system methodology. Adjusting for cigarette smoking, age, and occupational exposure to dust, men living within 50 m of a major roadway were more likely to report persistent wheeze (odds ratio [OR] = 1.3; 95% confidence interval [CI] = 1.0-1.7) compared with those living more than 400 m away. The risk was observed only for those living within 50 m of heavily trafficked roads (>/=10,000 vehicles/24 h): OR = 1.7; CI = 1.2-2.4). The risk of patients experiencing chronic phlegm while living on heavily trafficked roads also increased (OR = 1.4; CI = 1.0-2.0), although there was little evidence for an association with chronic cough. This association was not dependent on preexisting doctor-diagnosed chronic respiratory or heart disease. Exposure to vehicular emissions by living near busy roadways might contribute to symptoms of chronic respiratory disease in adults. JF - Epidemiology (Cambridge, Mass.) AU - Garshick, Eric AU - Laden, Francine AU - Hart, Jaime E AU - Caron, Amy AD - Pulmonary and Critical Care Medicine Section, Medical Service and Research Service, VA Boston Healthcare System, West Roxbury, MA 02132, USA. eric.garshick@med.va.gov Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 728 EP - 736 VL - 14 IS - 6 SN - 1044-3983, 1044-3983 KW - Vehicle Emissions KW - 0 KW - Index Medicus KW - Humans KW - Confounding Factors (Epidemiology) KW - Cohort Studies KW - Environmental Exposure KW - Aged KW - Middle Aged KW - Chronic Disease KW - Massachusetts -- epidemiology KW - Male KW - Veterans KW - Respiratory Tract Diseases -- etiology KW - Respiratory Tract Diseases -- epidemiology KW - Residence Characteristics KW - Vehicle Emissions -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71280418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Residence+near+a+major+road+and+respiratory+symptoms+in+U.S.+Veterans.&rft.au=Garshick%2C+Eric%3BLaden%2C+Francine%3BHart%2C+Jaime+E%3BCaron%2C+Amy&rft.aulast=Garshick&rft.aufirst=Eric&rft.date=2003-11-01&rft.volume=14&rft.issue=6&rft.spage=728&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-04 N1 - Date created - 2003-10-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2002 Mar 6;287(9):1132-41 [11879110] J Air Waste Manag Assoc. 2002 Sep;52(9):1032-42 [12269664] Arch Environ Health. 1973 Jun;26(6):319-24 [4122090] Am Rev Respir Dis. 1978 Dec;118(6 Pt 2):1-120 [742764] Am Rev Respir Dis. 1982 Jan;125(1):39-42 [7065507] Thorax. 1999 Dec;54(12):1070-4 [10567625] Arch Environ Health. 1994 Jul-Aug;49(4):223-7 [7518223] Ann Epidemiol. 1994 May;4(3):243-7 [7519948] Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 1):669-74 [7881654] Arch Environ Health. 1995 May-Jun;50(3):207-13 [7542442] Occup Environ Med. 1996 Apr;53(4):241-7 [8664961] Epidemiology. 1996 Nov;7(6):578-82 [8899382] Epidemiology. 1997 May;8(3):298-303 [9115026] Allergy. 1997;52(38 Suppl):26-9; discussion 35-6 [9208056] Environ Res. 1997;74(2):122-32 [9339225] Occup Environ Med. 1998 Nov;55(11):771-8 [9924455] J Med Assoc Thai. 1999 May;82(5):435-43 [10443092] Environ Health Perspect. 1999 Sep;107(9):761-7 [10464078] N Engl J Med. 1993 Dec 9;329(24):1753-9 [8179653] BMJ. 1993 Sep 4;307(6904):596-600 [7691304] Arch Environ Health. 1993 Jan-Feb;48(1):53-8 [7680850] Am Ind Hyg Assoc J. 1991 Dec;52(12):529-41 [1723577] Am J Ind Med. 1988;14(1):25-36 [2457311] Environ Res. 1987 Feb;42(1):201-14 [2433131] Environ Res. 1987 Oct;44(1):6-17 [2443345] Arch Environ Health. 1984 Nov-Dec;39(6):389-94 [6524958] Am J Ind Med. 1983;4(3):435-58 [6601909] Ann Occup Hyg. 1982;26(1-4):817-31 [7181309] Am J Respir Crit Care Med. 2001 Dec 15;164(12):2177-80 [11751183] Environ Health Perspect. 2000 Oct;108(10):941-7 [11049813] Occup Environ Med. 2000 Mar;57(3):152-8 [10810096] Occup Environ Med. 1999 Dec;56(12):802-12 [10658536] Ann Occup Hyg. 1982;26(1-4):799-815 [7181308] Environ Health Perspect. 1999 Dec;107(12):1001-6 [10585904] Epidemiology. 2000 Jan;11(1):64-70 [10615846] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A STEPWISE METHOD FOR THE ISOLATION OF ENDOTHELIAL CELLS AND SMOOTH MUSCLE CELLS FROM INDIVIDUAL CANINE CORONARY ARTERIES AN - 19332624; 8696246 AB - Methods for the stepwise isolation of endothelial cells and smooth muscle cells from individual canine coronary arteries are described. Both cell types can be isolated in pure culture with high yields. Dogs are a common species used in the study of atherosclerosis and coronary artery disease. Capacity to isolate endothelial cells and smooth muscle cells from individual canine coronary arteries should prove useful in the study of coronary artery disease. JF - In Vitro Cellular & Developmental Biology - Animal AU - Dame, Michael K AU - Yu, Xinwen AU - Garrido, Rosario AU - Bobrowski, Walter AU - Eric McDuffie, J AU - Murphy, Hedwig S AU - Albassam, Mudher AU - Varani, James AD - Department of Pathology, University of Michigan Medical School, 4224 Medical Science I Building, 1301 Catherine Street, Ann Arbor, Michigan 48109-0602 (M. K. D., H. S. M., J. V.), Pfizer Global Research and Development, Pfizer, 2800 Plymouth, Ann Arbor, Michigan 48105 (X. Y., R. G., W. B., J. E. M., M. A.), and Pathology and Laboratory Medicine, Veterans Administration Ann Arbor Health System, Ann Arbor, Michigan 48105-2303 (H. S. M.), mdame@med.umich.edu Y1 - 2003/11// PY - 2003 DA - Nov 2003 SP - 402 EP - 406 PB - Allen Press, Inc., 810 East Tenth St. VL - 39 IS - 10 SN - 1071-2690, 1071-2690 KW - Biotechnology and Bioengineering Abstracts KW - dog KW - culture KW - arteriosclerosis KW - heart KW - vasculature KW - circulation KW - Endothelial cells KW - Smooth muscle KW - Pure culture KW - Arteriosclerosis KW - Heart diseases KW - coronary artery KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19332624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.atitle=A+STEPWISE+METHOD+FOR+THE+ISOLATION+OF+ENDOTHELIAL+CELLS+AND+SMOOTH+MUSCLE+CELLS+FROM+INDIVIDUAL+CANINE+CORONARY+ARTERIES&rft.au=Dame%2C+Michael+K%3BYu%2C+Xinwen%3BGarrido%2C+Rosario%3BBobrowski%2C+Walter%3BEric+McDuffie%2C+J%3BMurphy%2C+Hedwig+S%3BAlbassam%2C+Mudher%3BVarani%2C+James&rft.aulast=Dame&rft.aufirst=Michael&rft.date=2003-11-01&rft.volume=39&rft.issue=10&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.issn=10712690&rft_id=info:doi/10.1290%2F1543-706X%282003%290392.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Pure culture; Smooth muscle; Endothelial cells; Arteriosclerosis; coronary artery; Heart diseases DO - http://dx.doi.org/10.1290/1543-706X(2003)039<0402:ASMFTI>2.0.CO;2 ER - TY - JOUR T1 - Radiation Safety Compliance Issues at Affiliated Institutions AN - 19228627; 5797520 AB - "Affiliation" may be defined as a collaborative interaction between two (or more) organizations in a spirit of mutual benefit through an equitable contribution of resources. Across the United States, hundreds of medical schools and healthcare organizations affiliate with one another for the enhancement of patient care, education, and research. Oftentimes, both parties in the affiliation have active clinical and research programs that involve the use of radioactive material (RAM). The combination of this close affiliation and use of radioactive material presents a number of challenging radiation safety compliance issues. It is important for radiation safety professionals (RSPs) employed by each affiliate to work together to ensure compliance with applicable regulatory requirements. JF - Health Physics AU - Michel, R AU - Zorn, MJ AD - VA San Diego, Healthcare System, rene.michel@med.va.gov Y1 - 2003/11// PY - 2003 DA - Nov 2003 SP - S78 EP - S80 VL - 85 IS - 5 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts KW - Education KW - Compliance KW - Radioactive materials KW - Occupational exposure KW - Research programs KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19228627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=Radiation+Safety+Compliance+Issues+at+Affiliated+Institutions&rft.au=Michel%2C+R%3BZorn%2C+MJ&rft.aulast=Michel&rft.aufirst=R&rft.date=2003-11-01&rft.volume=85&rft.issue=5&rft.spage=S78&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Education; Research programs; Radioactive materials; Occupational exposure; Compliance ER - TY - JOUR T1 - Biosynthetic specificity of the rhamnosyltransferase gene of Mycobacterium avium serovar 2 as determined by allelic exchange mutagenesis AN - 19175144; 5765274 AB - In prior studies, through recombinant expression in Mycobacterium smegmatis, the rtfA gene of Mycobacterium avium was shown to encode a rhamnosyltransferase that catalyses the addition of rhamnose (Rha) to the 6-deoxytalose of serovar 2-specific glycopeptidolipid (GPL). Whether RtfA also catalyses the transfer of Rha to the alaninol of the lipopeptide core is unknown. An isogenic rtfA mutant of M. avium serovar 2 strain TMC724 was derived using a novel allelic exchange mutagenesis system utilizing a multicopy plasmid that contained the katG gene of Mycobacterium bovis and the gene encoding green fluorescent protein (gfp). Overexpression of KatG in M. avium resulted in increased susceptibility to isoniazid, thus providing counter-selection by enriching for clones that had lost plasmid DNA. Plasmid loss was confirmed by screening for gfp-negative clones to select putative allelic exchange mutants. Two exchange mutants were created, confirmed by Southern hybridization, and demonstrated loss of serovar 2-specific GPL by thin-layer chromatography (TLC). Gas chromatography of alditol acetate derivatives revealed the loss of Rha and the terminal 2,3-O-Me-fucose and preservation of 3-O-Me-Rha and 3,4-O-Me-Rha substituents at the terminal alaninol of the lipopeptide core. Complementation of rtfA in trans through an integrative plasmid restored serovar 2-specific GPL expression identical to wild-type TMC724. This result shows that rtfA encodes an enzyme responsible only for the transfer of Rha to the serovar 2-specific oligosaccharide and provides a system of allelic exchange for M. avium as a tool for future genetic studies involving this species. JF - Microbiology AU - Maslow, J N AU - Irani, V R AU - Lee, S-H AU - Eckstein, T M AU - Inamine, J M AU - Belisle, J T AD - Section of Infectious Diseases, VA Medical Center (151), University and Woodland Aves, Philadelphia, PA 19104, USA, joel.maslow@med.va.gov Y1 - 2003/11// PY - 2003 DA - Nov 2003 SP - 3193 EP - 3202 VL - 149 IS - 11 SN - 1350-0872, 1350-0872 KW - 6-deoxytalose KW - oligosaccharides KW - rhamnosyltransferase KW - rtfA gene KW - Microbiology Abstracts B: Bacteriology KW - Mycobacterium avium KW - Overexpression KW - Mutagenesis KW - Mutants KW - Isoniazid KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19175144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology&rft.atitle=Biosynthetic+specificity+of+the+rhamnosyltransferase+gene+of+Mycobacterium+avium+serovar+2+as+determined+by+allelic+exchange+mutagenesis&rft.au=Maslow%2C+J+N%3BIrani%2C+V+R%3BLee%2C+S-H%3BEckstein%2C+T+M%3BInamine%2C+J+M%3BBelisle%2C+J+T&rft.aulast=Maslow&rft.aufirst=J&rft.date=2003-11-01&rft.volume=149&rft.issue=11&rft.spage=3193&rft.isbn=&rft.btitle=&rft.title=Microbiology&rft.issn=13500872&rft_id=info:doi/10.1099%2Fmic.0.26565-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium avium; Overexpression; Isoniazid; Mutants; Mutagenesis DO - http://dx.doi.org/10.1099/mic.0.26565-0 ER - TY - JOUR T1 - Extended-Spectrum beta -Lactamases in Klebsiella pneumoniae Bloodstream Isolates from Seven Countries: Dominance and Widespread Prevalence of SHV- and CTX-M-Type beta -Lactamases AN - 18951989; 5740972 AB - A huge variety of extended-spectrum beta -lactamases (ESBLs) have been detected during the last 20 years. The majority of these have been of the TEM or SHV lineage. We have assessed ESBLs occurring among a collection of 455 bloodstream isolates of Klebsiella pneumoniae, collected from 12 hospitals in seven countries. Multiple beta -lactamases were produced by isolates with phenotypic evidence of ESBL production (mean of 2.7 beta -lactamases per isolate; range, 1 to 5). SHV-type ESBLs were the most common ESBL, occurring in 67.1% (49 of 73) of isolates with phenotypic evidence of ESBL production. In contrast, TEM-type ESBLs (TEM-10 type, -12 type, -26 type, and -63 type) were found in just 16.4% (12 of 73) of isolates. The finding of TEM-10 type and TEM-12 type represents the first detection of a TEM-type ESBL in South America. PER (for Pseudomonas extended resistance)-type beta -lactamases were detected in five of the nine isolates from Turkey and were found with SHV-2-type and SHV-5-type ESBLs in two of the isolates. CTX-M-type ESBLs (bla sub(CTX-M-2) type and bla sub(CTX-M-3) type) were found in 23.3% (17 of 73) of isolates and were found in all study countries except for the United States. We also detected CTX- M-type ESBLs in four countries where they have previously not been described: Australia, Belgium, Turkey, and South Africa. The widespread emergence and proliferation of CTX-M-type ESBLs is particularly noteworthy and may have important implications for clinical microbiology laboratories and for physicians treating patients with serious K. pneumoniae infections. JF - Antimicrobial Agents & Chemotherapy AU - Paterson, D L AU - Hujer, K M AU - Hujer, AM AU - Yeiser, B AU - Bonomo, MD AU - Rice, L B AD - Section of Infectious Diseases, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, Robert.bonomo@med.va.gov Y1 - 2003/11// PY - 2003 DA - Nov 2003 SP - 3554 EP - 3560 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 47 IS - 11 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Geographical distribution KW - ^b-Lactamase KW - Antibiotic resistance KW - Hospitals KW - Klebsiella pneumoniae KW - J 02841:Microflora KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18951989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Extended-Spectrum+beta+-Lactamases+in+Klebsiella+pneumoniae+Bloodstream+Isolates+from+Seven+Countries%3A+Dominance+and+Widespread+Prevalence+of+SHV-+and+CTX-M-Type+beta+-Lactamases&rft.au=Paterson%2C+D+L%3BHujer%2C+K+M%3BHujer%2C+AM%3BYeiser%2C+B%3BBonomo%2C+MD%3BRice%2C+L+B&rft.aulast=Paterson&rft.aufirst=D&rft.date=2003-11-01&rft.volume=47&rft.issue=11&rft.spage=3554&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.47.11.3554-3560.2003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Klebsiella pneumoniae; ^b-Lactamase; Clinical isolates; Hospitals; Geographical distribution; Antibiotic resistance DO - http://dx.doi.org/10.1128/AAC.47.11.3554-3560.2003 ER - TY - JOUR T1 - Skin and soft-tissue infections: impact of resistant gram-positive bacteria AN - 1566831002; 19353472 AB - Surgical site infections remain significant causes of postoperative morbidity and mortality despite an improved understanding of risk factors and an increasing armamentarium of antimicrobial agents. The overall rates of surgical site infections have been slowly decreasing, but the proportion of infections with gram-positive bacteria continues to increase, and drug-resistant species continue to become more prevalent. Although new antibiotic classes have efficacy against such organisms, these agents are only short-term solutions to the problem of multiple-drug resistance. Surgeons must focus on prevention of infections by appropriately using antibiotics, emphasizing principles of infection control, and understanding nontraditional measures that may decrease infection risk. JF - American Journal of Surgery AU - Wilson, Mark A AD - Veterans Administration Pittsburgh Healthcare System and Department of Surgery, University of Pittsburgh, University Drive C (112), Pittsburgh, Pennsylvania 15230, USA Y1 - 2003/11// PY - 2003 DA - Nov 2003 SP - 35 EP - 41 PB - Elsevier B.V., Radarweg 29 Amsterdam 1043 NX Netherlands VL - 186 IS - 5 SN - 0002-9610, 0002-9610 KW - Microbiology Abstracts B: Bacteriology KW - Mortality KW - Skin KW - Gram-positive bacteria KW - Risk factors KW - Drug resistance KW - Antibiotics KW - Infection KW - Morbidity KW - Antimicrobial agents KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566831002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Surgery&rft.atitle=Skin+and+soft-tissue+infections%3A+impact+of+resistant+gram-positive+bacteria&rft.au=Wilson%2C+Mark+A&rft.aulast=Wilson&rft.aufirst=Mark&rft.date=2003-11-01&rft.volume=186&rft.issue=5&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Surgery&rft.issn=00029610&rft_id=info:doi/10.1016%2Fj.amjsurg.2003.10.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Mortality; Skin; Drug resistance; Risk factors; Gram-positive bacteria; Antibiotics; Infection; Morbidity; Antimicrobial agents DO - http://dx.doi.org/10.1016/j.amjsurg.2003.10.006 ER - TY - JOUR T1 - State-of-the-art therapy for severe sepsis and multisystem organ dysfunction AN - 1560136563; 19353474 AB - Despite spectacular advances in life-support technology, the management of patients with severe sepsis continues to be a significant health care challenge because of the associated major morbidity, high mortality, and health economic implications. Severe sepsis with associated multisystem organ dysfunction (MOD) is the leading cause of death in the intensive care unit. Recent understanding of the pathophysiology now demonstrates that the syndrome of severe sepsis after a major physiologic insult is characterized by the activation of multiple overlapping and interacting cascades leading to systemic inflammation, a procoagulant state, and decreased fibrinolysis, which if unchecked leads to the progressive functional deterioration of multiple interdependent organs. This review will highlight the epidemiology, current understanding of the pathophysiology, management, and prevention of the syndrome of severe sepsis with MOD. JF - American Journal of Surgery AU - Awad, Samir S AD - Houston Veterans Administration Medical Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, Texas 77030, USA Y1 - 2003/11// PY - 2003 DA - Nov 2003 SP - 23 EP - 30 PB - Elsevier B.V., Radarweg 29 Amsterdam 1043 NX Netherlands VL - 186 IS - 5 SN - 0002-9610, 0002-9610 KW - Microbiology Abstracts B: Bacteriology KW - Mortality KW - Sepsis KW - Intensive care units KW - Epidemiology KW - Reviews KW - Economics KW - Fibrinolysis KW - Morbidity KW - Inflammation KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560136563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Surgery&rft.atitle=State-of-the-art+therapy+for+severe+sepsis+and+multisystem+organ+dysfunction&rft.au=Awad%2C+Samir+S&rft.aulast=Awad&rft.aufirst=Samir&rft.date=2003-11-01&rft.volume=186&rft.issue=5&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Surgery&rft.issn=00029610&rft_id=info:doi/10.1016%2Fj.amjsurg.2003.10.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Mortality; Sepsis; Epidemiology; Intensive care units; Reviews; Economics; Fibrinolysis; Morbidity; Inflammation DO - http://dx.doi.org/10.1016/j.amjsurg.2003.10.004 ER - TY - JOUR T1 - Early detection of ototoxicity using 1/6th-octave steps. AN - 85367455; pmid-14655957 AB - The National Center for Rehabilitative Auditory Research has developed a protocol to provide early identification of ototoxicity for patients receiving ototoxic medications. The initial work involved patients with relatively good high-frequency hearing and resulted in the use of an individualized, sensitive frequency range separated by 1/6th-octave intervals. This protocol tested pure-tone frequencies at 1/6th-octave steps above 9 kHz, but only conventional audiometric frequencies were tested below 9 kHz. More recently, the testing protocol was expanded to include 1/6th-octave testing below 9 kHz. The primary question of interest was to determine whether adding 1/6th-octave test frequencies below 9 kHz would increase the ototoxicity detection rate for patients with poorer hearing. Results indicated 76 of the 210 (36.2%) ears that demonstrated initial ototoxic hearing change would have been missed or detected later if only conventional frequency testing was conducted.Therefore, for individuals with poorer hearing, expanding the use of the 1/6th-octave test protocol provides earlier identification of ototoxicity. JF - Journal of the American Academy of Audiology AU - Fausti, Stephen A AU - Helt, Wendy J AU - Phillips, David S AU - Gordon, Jane S AU - Bratt, Gene W AU - Sugiura, Karen M AU - Noffsinger, Douglas AD - VA RR&D National Center for Rehabilitative Auditory Research, Portland VA Medical Center, Portland, Oregon 97239, USA. Stephen.fausti@med.va.gov Y1 - 2003/10// PY - 2003 DA - Oct 2003 SP - 444 EP - 450 VL - 14 IS - 8 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Aged, 80 and over KW - *Anti-Bacterial Agents: adverse effects KW - *Antineoplastic Agents: adverse effects KW - Audiometry, Pure-Tone: methods KW - *Auditory Threshold: drug effects KW - Female KW - Follow-Up Studies KW - *Hearing Loss, Sensorineural: chemically induced KW - *Hearing Loss, Sensorineural: diagnosis KW - Humans KW - Male KW - Middle Aged UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85367455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Early+detection+of+ototoxicity+using+1%2F6th-octave+steps.&rft.au=Fausti%2C+Stephen+A%3BHelt%2C+Wendy+J%3BPhillips%2C+David+S%3BGordon%2C+Jane+S%3BBratt%2C+Gene+W%3BSugiura%2C+Karen+M%3BNoffsinger%2C+Douglas&rft.aulast=Fausti&rft.aufirst=Stephen&rft.date=2003-10-01&rft.volume=14&rft.issue=8&rft.spage=444&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Time-frequency analyses of transient-evoked stimulus-frequency and distortion-product otoacoustic emissions: testing cochlear model predictions. AN - 85364400; pmid-14587602 AB - Time-frequency representations (TFRs) of otoacoustic emissions (OAEs) provide information simultaneously in time and frequency that may be obscured in waveform or spectral analyses. TFRs were applied to transient-evoked stimulus-frequency (SF) and distortion-product (DP) OAEs to test cochlear model predictions. SFOAEs and DPOAEs were elicited in 18 normal-hearing subjects using gated tones and tone pips. Synchronous spontaneous (SS) OAEs were measured to assess their contributions to SFOAEs and DPOAEs. A common form of TFR of measured OAEs was a collection of frequency-specific components often aligned with SSOAE sites, with each component characterized by one or more brief segments or a single long-duration segment. The spectral envelope of evoked OAEs differed from that of the evoking stimulus. Strong emission regions or cochlear "hot spots" were detected, and sometimes accounted for OAE energy observed outside the stimulus bandwidth. Contributions of hot spots and multiple internal reflections to the OAE, and differences between measured and predicted OAE spectra, increased as stimulus level decreased, consistent with level-dependent changes in the estimated cochlear reflectance. Suppression and frequency-pulling effects between components were observed. A recursive formulation was described for the linear coherent reflection emission theory [Zweig and Shera, J. Acoust. Soc. Am. 98, 2018-2047 (1995)] that is well suited for time-domain calculations. JF - The Journal of the Acoustical Society of America AU - Konrad-Martin, Dawn AU - Keefe, Douglas H AD - VA RR&D National Center For Rehabilitative Auditory Research, Portland VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, USA. dawn.martin@med.va.gov Y1 - 2003/10// PY - 2003 DA - Oct 2003 SP - 2021 EP - 2043 VL - 114 IS - 4 Pt 1 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Acoustic Stimulation KW - Adolescent KW - Adult KW - Basilar Membrane: physiology KW - Child KW - *Cochlea: physiology KW - Fourier Analysis KW - Humans KW - Middle Aged KW - *Models, Neurological KW - *Otoacoustic Emissions, Spontaneous: physiology KW - *Perceptual Distortion: physiology KW - Reference Values KW - *Signal Processing, Computer-Assisted KW - *Sound Spectrography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85364400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Time-frequency+analyses+of+transient-evoked+stimulus-frequency+and+distortion-product+otoacoustic+emissions%3A+testing+cochlear+model+predictions.&rft.au=Konrad-Martin%2C+Dawn%3BKeefe%2C+Douglas+H&rft.aulast=Konrad-Martin&rft.aufirst=Dawn&rft.date=2003-10-01&rft.volume=114&rft.issue=4+Pt+1&rft.spage=2021&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Evaluating the clinical effectiveness of 90Y-SMT 487 in patients with neuroendocrine tumors. AN - 75749031; 14530466 AB - Because of the presence of cell membrane somatostatin receptors (SSTRs), many neuroendocrine tumors will bind analogs of somatostatin. (90)Y-Dodecanetetraacetic acid-Phe1-Tyr3-octreotide (SMT 487) is an SSTR radiopharmaceutical currently under investigation as a therapeutic option for neuroendocrine tumors. Although there are a variety of methods for evaluating response to a given cancer therapy, an important indicator of success is the impact on the clinical status of the patient. The purpose of this work was to develop a semiquantitative method and assess the clinical effectiveness of (90)Y-SMT 487 therapy in patients with neuroendocrine tumors. A scoring system was developed to evaluate clinical response that included the following parameters: weight, health status score (determined by the patient), Karnofsky score, and tumor-related symptoms. We applied this scoring system to 21 patients who had completed 3 cycles of therapy with (90)Y-SMT 487. Fourteen of the 21 showed a favorable clinical response, whereas 5 were clinically stable after treatment and 2 showed evidence of clinical progression. There was also a significant reduction in the amount of octreotide being used after completion of (90)Y-SMT 487 therapy in the 20 patients who were on this medication. Using this scoring method, (90)Y-SMT 487 appears effective in improving the clinical status of patients with (111)In-pentetreotide-positive neuroendocrine tumors. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Bushnell, David AU - O'Dorisio, Thomas AU - Menda, Yusuf AU - Carlisle, Thomas AU - Zehr, Pamela AU - Connolly, Mary AU - Karwal, Mark AU - Miller, Sara AU - Parker, Stan AU - Bouterfa, Hakim AD - Iowa City Veterans Administration Hospital, Diagnostic Imaging and Radioisotope Therapy Service, and Department of Radiology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, 55240, USA. david-bushnell@uiowa.edu Y1 - 2003/10// PY - 2003 DA - October 2003 SP - 1556 EP - 1560 VL - 44 IS - 10 SN - 0161-5505, 0161-5505 KW - Radiopharmaceuticals KW - 0 KW - Yttrium Radioisotopes KW - Octreotide KW - RWM8CCW8GP KW - Edotreotide KW - U194AS08HZ KW - Index Medicus KW - Radiopharmaceuticals -- administration & dosage KW - Injections, Intravenous KW - Radiotherapy Dosage KW - Humans KW - Adult KW - Treatment Outcome KW - Quality of Life KW - Aged KW - Middle Aged KW - Radiography KW - Dose-Response Relationship, Radiation KW - Male KW - Female KW - Yttrium Radioisotopes -- administration & dosage KW - Neuroendocrine Tumors -- secondary KW - Octreotide -- analogs & derivatives KW - Neuroendocrine Tumors -- diagnostic imaging KW - Neuroendocrine Tumors -- diagnosis KW - Neuroendocrine Tumors -- radiotherapy KW - Octreotide -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75749031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Evaluating+the+clinical+effectiveness+of+90Y-SMT+487+in+patients+with+neuroendocrine+tumors.&rft.au=Bushnell%2C+David%3BO%27Dorisio%2C+Thomas%3BMenda%2C+Yusuf%3BCarlisle%2C+Thomas%3BZehr%2C+Pamela%3BConnolly%2C+Mary%3BKarwal%2C+Mark%3BMiller%2C+Sara%3BParker%2C+Stan%3BBouterfa%2C+Hakim&rft.aulast=Bushnell&rft.aufirst=David&rft.date=2003-10-01&rft.volume=44&rft.issue=10&rft.spage=1556&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-12-22 N1 - Date created - 2003-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Somnambulism due to probable interaction of valproic acid and zolpidem. AN - 75729801; 14519043 AB - To report a case of somnambulism due to a probable interaction between valproic acid and zolpidem in a patient with no prior personal or family history of somnambulism. A 47-year-old white man with a history of bipolar disorder was being maintained on citalopram 40 mg once daily and zolpidem 5 mg at bedtime. During treatment, he developed manic symptoms and was started on adjunctive valproic acid therapy. Soon after this, he developed episodes of somnambulism, which stopped when valproic acid was discontinued. On rechallenge with valproic acid, somnambulism returned. To our knowledge, this is the first report in the literature describing a probable interaction between valproic acid and zolpidem leading to somnambulism. Even though valproic acid has been associated with sleep changes, there are no published reports of somnambulism with this agent. Zolpidem has been associated with somnambulism, but our patient did not experience this when he was on zolpidem monotherapy. However, within 2 days of starting adjunctive valproic acid, sleepwalking occurred. It stopped after valproic acid was withdrawn. On rechallenge with valproic acid, sleepwalking recurred. However, when zolpidem was discontinued and valproic acid was continued, somnambulism did not occur. An assessment on the Naranjo probability scale suggests probable pharmacokinetic or pharmacodynamic interactions between the 2 medications. Valproic acid and zolpidem are generally safe medications that are commonly prescribed and often used together. No interactions have been previously reported with combined use of valproic acid and zolpidem. This case suggests a probable interaction between these 2 agents that can have a serious consequence, somnambulism. This could be frightening to patients and put them in danger. Recognition of such interactions that place patients at risk for potentially serious adverse events is imperative for appropriate care. JF - The Annals of pharmacotherapy AU - Sattar, S Pirzada AU - Ramaswamy, Sriram AU - Bhatia, Subhash C AU - Petty, Frederick AD - Department of Psychiatry, School of Medicine, Creighton University, Omaha, NE, USA. syed.sattar@med.va.gov Y1 - 2003/10// PY - 2003 DA - October 2003 SP - 1429 EP - 1433 VL - 37 IS - 10 SN - 1060-0280, 1060-0280 KW - Pyridines KW - 0 KW - Citalopram KW - 0DHU5B8D6V KW - Valproic Acid KW - 614OI1Z5WI KW - zolpidem KW - 7K383OQI23 KW - Index Medicus KW - Drug Therapy, Combination KW - Citalopram -- therapeutic use KW - Sleep Initiation and Maintenance Disorders -- drug therapy KW - Humans KW - Depression -- complications KW - Sleep Initiation and Maintenance Disorders -- complications KW - Bipolar Disorder -- drug therapy KW - Depression -- drug therapy KW - Middle Aged KW - Citalopram -- administration & dosage KW - Citalopram -- metabolism KW - Time Factors KW - Male KW - Bipolar Disorder -- complications KW - Drug Interactions KW - Pyridines -- administration & dosage KW - Pyridines -- therapeutic use KW - Valproic Acid -- metabolism KW - Valproic Acid -- therapeutic use KW - Pyridines -- metabolism KW - Valproic Acid -- administration & dosage KW - Somnambulism -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75729801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Somnambulism+due+to+probable+interaction+of+valproic+acid+and+zolpidem.&rft.au=Sattar%2C+S+Pirzada%3BRamaswamy%2C+Sriram%3BBhatia%2C+Subhash+C%3BPetty%2C+Frederick&rft.aulast=Sattar&rft.aufirst=S&rft.date=2003-10-01&rft.volume=37&rft.issue=10&rft.spage=1429&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-26 N1 - Date created - 2003-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Self-help for substance-use disorders: history, effectiveness, knowledge gaps, and research opportunities. AN - 73651948; 12971904 AB - Scientific evidence suggests substance-use disorder (SUD)-focused self-help group involvement is a helpful adjunct to SUD treatment, yet significant knowledge gaps remain. The principal aim of this review is to highlight areas of knowledge deficit and their implications for research and practice. To accomplish this, evidence regarding whether self-help group involvement is effective, for whom, and why, is reviewed. The appropriateness of self-help groups for certain subpopulations is considered with respect to psychiatric comorbidity, religious orientation, gender, and age. An increasingly rigorous body of evidence suggests consistent benefits of self-help group involvement. Regarding subpopulations, current evidence suggests non- or less-religious individuals benefit as much from self-help groups as more religious individuals and women become as involved and benefit as much as men. However, participation in, and effects from, traditional self-help groups for dually diagnosed patients may be moderated by type of psychiatric comorbidity. Some youth appear to benefit, but remain largely unstudied. Dropout and nonattendance rates are high, despite clinical recommendations to attend. Clinicians can significantly influence the effectiveness of self-help, but optimal methods and duration of facilitation efforts need testing. Greater understanding of the reasons why many do not attend or drop out would benefit facilitation efforts. JF - Clinical psychology review AU - Kelly, John F AD - Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System, Menlo Park, CA 94025, USA. john.kelly4@med.va.gov Y1 - 2003/10// PY - 2003 DA - October 2003 SP - 639 EP - 663 VL - 23 IS - 5 SN - 0272-7358, 0272-7358 KW - Index Medicus KW - United States KW - History, 20th Century KW - Treatment Outcome KW - Substance-Related Disorders -- therapy KW - Research KW - Substance-Related Disorders -- history KW - Alcoholics Anonymous -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73651948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+psychology+review&rft.atitle=Self-help+for+substance-use+disorders%3A+history%2C+effectiveness%2C+knowledge+gaps%2C+and+research+opportunities.&rft.au=Kelly%2C+John+F&rft.aulast=Kelly&rft.aufirst=John&rft.date=2003-10-01&rft.volume=23&rft.issue=5&rft.spage=639&rft.isbn=&rft.btitle=&rft.title=Clinical+psychology+review&rft.issn=02727358&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-08 N1 - Date created - 2003-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase I clinical study of a static magnetic field combined with anti-neoplastic chemotherapy in the treatment of human malignancy: initial safety and toxicity data. AN - 73632840; 12955758 AB - We have completed the lowest level of exposure in a Phase I study, designed to establish the safety and toxicity of the combination of a static magnetic field (SMF) and antineoplastic chemotherapy in patients with advanced malignancy. The SMF application is carefully controlled by applying the magnet to the patient only in our clinic during chemotherapy administration. No increase in the severity of chemotherapy toxicity as measured by white blood cell count and platelet count was seen in the participants exposed to SMF compared to the historical control subjects. These data have permitted the next group of subjects to be treated at the next dose level. Published 2003 Wiley-Liss, Inc. JF - Bioelectromagnetics AU - Salvatore, Joseph R AU - Harrington, Joanne AU - Kummet, Thomas AD - Division of Hematology-Oncology, Carl T Hayden VA Medical Center, Phoenix, Arizona 85012, USA. joseph.salvatore@med.va.gov Y1 - 2003/10// PY - 2003 DA - October 2003 SP - 524 EP - 527 VL - 24 IS - 7 SN - 0197-8462, 0197-8462 KW - Antineoplastic Agents KW - 0 KW - Vincristine KW - 5J49Q6B70F KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Combined Modality Therapy -- methods KW - Radiation Dosage KW - Antineoplastic Agents -- administration & dosage KW - Humans KW - Aged KW - Dose-Response Relationship, Radiation KW - Risk Assessment -- methods KW - Leukocyte Count KW - Antineoplastic Agents -- adverse effects KW - Toxicity Tests KW - Electromagnetic Fields -- adverse effects KW - Middle Aged KW - Female KW - Male KW - Platelet Count KW - Cyclophosphamide -- administration & dosage KW - Neoplasms -- drug therapy KW - Doxorubicin -- adverse effects KW - Vincristine -- adverse effects KW - Neoplasms -- blood KW - Vincristine -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Doxorubicin -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Magnetics -- therapeutic use KW - Neoplasms -- therapy KW - Cyclophosphamide -- adverse effects KW - Prednisone -- adverse effects KW - Magnetics -- adverse effects KW - Prednisone -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73632840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioelectromagnetics&rft.atitle=Phase+I+clinical+study+of+a+static+magnetic+field+combined+with+anti-neoplastic+chemotherapy+in+the+treatment+of+human+malignancy%3A+initial+safety+and+toxicity+data.&rft.au=Salvatore%2C+Joseph+R%3BHarrington%2C+Joanne%3BKummet%2C+Thomas&rft.aulast=Salvatore&rft.aufirst=Joseph&rft.date=2003-10-01&rft.volume=24&rft.issue=7&rft.spage=524&rft.isbn=&rft.btitle=&rft.title=Bioelectromagnetics&rft.issn=01978462&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-26 N1 - Date created - 2003-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Detection of radiation-accelerated atherosclerosis of the carotid artery by panoramic radiography. A new opportunity for dentists. AN - 71355782; 14620017 AB - The authors review the pathophysiology, epidemiology, course of disease, dental findings and dental treatment of patients who developed atherosclerosis of the carotid artery after having received therapeutic radiation to the neck for squamous-cell carcinoma of the oral cavity, pharynx or larynx; salivary gland tumors; and lymphomas involving the cervical lymph nodes. The authors conducted a MEDLINE search for 1997 through 2002 using the key terms "radiation therapy," "carotid artery" "atherosclerosis," "cancer" and "dentistry." The articles selected for further review included those published in English in peer-reviewed journals, with preference given to articles reporting randomized, controlled trials. Recent advances in the delivery of radiation therapy to malignancies of the head and neck have resulted in the prolonged survival of increasing numbers of patients. However, the therapy has been implicated as causing atherosclerotic lesions in the cervical component of the carotid artery, which predisposes patients to an increased risk of developing stroke. Panoramic radiography can identify some of these lesions before they can cause a stroke. Radiation-induced atherosclerosis is common, with approximately 40 percent of patients developing hemodynamically significant carotid artery plaques within 10 years of having received irradiation. Dentists treating patients who have received therapeutic radiation to the neck should examine the patients' panoramic radiographs for evidence of atheromalike calcifications, which appear 1.5 to 2.5 centimeters posterior and inferior to the angle of the mandible. Patients with evidence of such lesions should be referred to their physician for an ultrasound examination of their carotid arteries. JF - Journal of the American Dental Association (1939) AU - Friedlander, Arthur H AU - Freymiller, Earl G AD - Graduate Medical Education, VA Greater Los Angeles Healthcare System, Calif. 90073, USA. arthur.friedlander@med.va.gov Y1 - 2003/10// PY - 2003 DA - October 2003 SP - 1361 EP - 1365 VL - 134 IS - 10 SN - 0002-8177, 0002-8177 KW - Dentistry KW - Index Medicus KW - Humans KW - Head and Neck Neoplasms -- radiotherapy KW - Radiography, Panoramic KW - Carotid Arteries -- radiation effects KW - Carcinoma, Squamous Cell -- radiotherapy KW - Radiation Injuries -- etiology KW - Cranial Irradiation -- adverse effects KW - Carotid Stenosis -- diagnostic imaging KW - Carotid Stenosis -- etiology KW - Arteriosclerosis -- diagnostic imaging KW - Arteriosclerosis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71355782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Detection+of+radiation-accelerated+atherosclerosis+of+the+carotid+artery+by+panoramic+radiography.+A+new+opportunity+for+dentists.&rft.au=Friedlander%2C+Arthur+H%3BFreymiller%2C+Earl+G&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2003-10-01&rft.volume=134&rft.issue=10&rft.spage=1361&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-06 N1 - Date created - 2003-11-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Outcome variables and their assessment in alcohol treatment studies: 1968-1998. AN - 71291240; 14574240 AB - This article provides a historical overview of the assessment of outcome variables in alcohol treatment studies that were first published between 1968 and 1998. The review focuses on changes over time in (1) the number of outcome variables and the number of different types of outcome variables assessed, (2) the likelihood of assessing specific types of outcome variables, (3) the methods used to assess outcome variables, and (4) the status of outcome assessment in more recent studies first published between 1990 and 1998. Reports of 357 alcohol treatment trials with two or more treatment/control groups were coded with respect to the number and types of outcome variables assessed, sources of outcome data, and methodological aspects of outcome assessment. Although the number of outcome variables assessed in studies, on average, did not increase significantly over time, the number of different types of outcome variables did increase. An expected decrease in the assessment of categorical abstinence was not found, but another categorical variable, global ratings of drinking improvement, did decrease over time. More recent studies were more likely to assess such continuous variables as time abstinent, alcohol consumption, time drinking, dependence symptoms, and drinking-related problems. Physiological markers of drinking/alcohol misuse also were assessed more frequently in later years. Some aspects of outcome assessment methods exhibited improvement over time; validity data were more likely to be provided or cited, and self-reports of drinking behaviors were more likely to be corroborated in studies first published in more recent years. However, the percentages of studies that provided/cited reliability data for outcome measures, indicated that follow-up data collectors were not affiliated with treatment and were unaware of respondents' treatment conditions, and reported that respondents were alcohol-free at follow-up did not rise significantly over time. Although the methods of outcome assessment improved between 1968 and 1998, much room for improvement remains. JF - Alcoholism, clinical and experimental research AU - Finney, John W AU - Moyer, Anne AU - Swearingen, Carolyn E AD - Center for Health Care Evaluation, VA Pao Alto Health Care System, Menlo Park, California 94087, USA. John.Finney@med.va.gov Y1 - 2003/10// PY - 2003 DA - October 2003 SP - 1671 EP - 1679 VL - 27 IS - 10 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Humans KW - Treatment Outcome KW - Alcoholism -- epidemiology KW - Alcoholism -- therapy KW - Clinical Trials as Topic -- trends KW - Clinical Trials as Topic -- methods KW - Clinical Trials as Topic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71291240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Outcome+variables+and+their+assessment+in+alcohol+treatment+studies%3A+1968-1998.&rft.au=Finney%2C+John+W%3BMoyer%2C+Anne%3BSwearingen%2C+Carolyn+E&rft.aulast=Finney&rft.aufirst=John&rft.date=2003-10-01&rft.volume=27&rft.issue=10&rft.spage=1671&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-06-15 N1 - Date created - 2003-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug interactions between the proteasome inhibitor bortezomib and cytotoxic chemotherapy, tumor necrosis factor (TNF) alpha, and TNF-related apoptosis-inducing ligand in prostate cancer. AN - 71272703; 14555528 AB - Proteasome inhibition has been shown to be an effective anticancer therapy in many tumor models, including prostate cancer. We sought to identify drug interactions between the proteasome inhibitor bortezomib and other apoptotic stimuli, including cytotoxic chemotherapy and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). In addition, we wanted to gain insight into the role of nuclear factor kappaB inhibition as a mediator of bortezomib cytotoxic effects. Prostate cancer cell lines (LNCaP, LAPC4, CL1, and DU145) were treated with bortezomib and apoptotic stimuli (TRAIL, chemotherapy, and tumor necrosis factor alpha), alone or in combination. Apoptosis and cell viability were measured, and median effect/combination index analyses were used to quantitate drug interactions. Nuclear factor kappaB activity at baseline and in response to drug treatment was determined by gel shift and reporter gene assays. Bortezomib induced cell death of androgen-dependent (LNCaP and LAPC4) and androgen-independent (CL1 and DU145) prostate cancer cell lines, although androgen-dependent cells were more sensitive to proteasome inhibition. Bortezomib synergized with TRAIL and tumor necrosis factor alpha to induce death in both androgen-dependent and androgen-independent cells. Bortezomib and TRAIL represent a synergistic drug combination that warrants further evaluation in in vivo models of prostate cancer. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - An, Jiabin AU - Sun, Yi-Ping AU - Adams, Julian AU - Fisher, Myrna AU - Belldegrun, Arie AU - Rettig, Matthew B AD - Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA. Y1 - 2003/10/01/ PY - 2003 DA - 2003 Oct 01 SP - 4537 EP - 4545 VL - 9 IS - 12 SN - 1078-0432, 1078-0432 KW - Androgens KW - 0 KW - Antineoplastic Agents KW - Apoptosis Regulatory Proteins KW - Boronic Acids KW - Membrane Glycoproteins KW - Multienzyme Complexes KW - NF-kappa B KW - Protease Inhibitors KW - Pyrazines KW - TNF-Related Apoptosis-Inducing Ligand KW - TNFSF10 protein, human KW - Tumor Necrosis Factor-alpha KW - Bortezomib KW - 69G8BD63PP KW - Luciferases KW - EC 1.13.12.- KW - Cysteine Endopeptidases KW - EC 3.4.22.- KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Drug Interactions KW - Humans KW - Electrophoretic Mobility Shift Assay KW - Luciferases -- metabolism KW - Androgens -- pharmacology KW - Tumor Cells, Cultured KW - Cell Survival -- drug effects KW - Multienzyme Complexes -- antagonists & inhibitors KW - Male KW - NF-kappa B -- metabolism KW - Protease Inhibitors -- therapeutic use KW - Prostatic Neoplasms -- metabolism KW - Pyrazines -- therapeutic use KW - Membrane Glycoproteins -- therapeutic use KW - Apoptosis -- drug effects KW - Prostatic Neoplasms -- drug therapy KW - Tumor Necrosis Factor-alpha -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Boronic Acids -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71272703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Drug+interactions+between+the+proteasome+inhibitor+bortezomib+and+cytotoxic+chemotherapy%2C+tumor+necrosis+factor+%28TNF%29+alpha%2C+and+TNF-related+apoptosis-inducing+ligand+in+prostate+cancer.&rft.au=An%2C+Jiabin%3BSun%2C+Yi-Ping%3BAdams%2C+Julian%3BFisher%2C+Myrna%3BBelldegrun%2C+Arie%3BRettig%2C+Matthew+B&rft.aulast=An&rft.aufirst=Jiabin&rft.date=2003-10-01&rft.volume=9&rft.issue=12&rft.spage=4537&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-20 N1 - Date created - 2003-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevention and treatment of bacterial diseases caused by bacterial bioterrorism threat agents. AN - 71262759; 14554016 AB - There is general consensus that the bacterial agents or products most likely to be used as weapons of mass destruction are Bacillus anthracis, Yersinia pestis, Francisella tularensis and the neurotoxin of Clostridium botulinum. Modern supportive and antimicrobial therapy for inhalational anthrax is associated with a 45% mortality rate, reinforcing the need for better adjunctive therapy and prevention strategies. Pneumonic plague is highly contagious, difficult to recognize and is frequently fatal. Therefore, the development of vaccines against this agent is crucial. Although tularemia is associated with low mortality, the highly infectious nature of aerosolized F. tularensis poses a substantive threat that is best met by vaccine development. Safer antitoxins and a vaccine are required to meet the threat of the use of botulinum toxin as a weapon of mass destruction. In this article, the current status of research in these areas is reviewed. JF - Drug discovery today AU - Greenfield, Ronald A AU - Bronze, Michael S AD - The Infectious Diseases Section, Department of Medicine, University of Oklahoma Health Sciences Center, & The Oklahoma City Veterans Administration Medical Center, Oklahoma City, OK 73190, USA. Ronald-Greenfield@ouhsc.edu Y1 - 2003/10/01/ PY - 2003 DA - 2003 Oct 01 SP - 881 EP - 888 VL - 8 IS - 19 SN - 1359-6446, 1359-6446 KW - Adjuvants, Immunologic KW - 0 KW - Anti-Bacterial Agents KW - Antitoxins KW - Bacterial Vaccines KW - Vaccines, DNA KW - Index Medicus KW - Botulism -- drug therapy KW - Anti-Bacterial Agents -- therapeutic use KW - Botulism -- prevention & control KW - Plague -- prevention & control KW - Vaccines, DNA -- therapeutic use KW - Humans KW - Anthrax -- prevention & control KW - Tularemia -- drug therapy KW - Plague -- drug therapy KW - Tularemia -- prevention & control KW - Antitoxins -- therapeutic use KW - Anthrax -- drug therapy KW - Adjuvants, Immunologic -- therapeutic use KW - Infection Control KW - Bioterrorism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71262759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+discovery+today&rft.atitle=Prevention+and+treatment+of+bacterial+diseases+caused+by+bacterial+bioterrorism+threat+agents.&rft.au=Greenfield%2C+Ronald+A%3BBronze%2C+Michael+S&rft.aulast=Greenfield&rft.aufirst=Ronald&rft.date=2003-10-01&rft.volume=8&rft.issue=19&rft.spage=881&rft.isbn=&rft.btitle=&rft.title=Drug+discovery+today&rft.issn=13596446&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-28 N1 - Date created - 2003-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of angiogenesis by NSAIDs: molecular mechanisms and clinical implications. AN - 71261880; 13679997 AB - Angiogenesis, the formation of new capillary blood vessels, is a fundamental process essential for reproduction and embryonic development. It is crucial to the healing of tissue injury because it provides essential oxygen and nutrients to the healing site. Angiogenesis is also required for cancer growth and progression since tumor growth requires an increased nutrient and oxygen supply. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used drugs worldwide for treating pain, arthritis, cardiovascular diseases, and more recently for colon cancer prevention. However, NSAIDs produce gastrointestinal ulcers and delay ulcer healing. Recently NSAIDs have been demonstrated to inhibit angiogenesis, but the underlying mechanisms are only beginning to be elucidated. The inhibition of angiogenesis by NSAIDs is a causal factor in the delay of ulcer healing, and it is becoming clear that this is also likely to be one of the mechanisms by which NSAIDs can reduce or prevent cancer growth. Based on the experimental data and the literature, the mechanisms by which NSAIDs inhibit angiogenesis appear to be multifactorial and likely include local changes in angiogenic growth factor expression, alteration in key regulators and mediators of vascular endothelial growth factor (VEGF), increased endothelial cell apoptosis, inhibition of endothelial cell migration, recruitment of inflammatory cells and platelets, and/or thromboxane A2 mediated effects. Some of these mechanisms include: inhibition of mitogen-activated protein (Erk2) kinase activity; suppression of cell cycle proteins; inhibition of early growth response (Egr-1) gene activation; interference with hypoxia inducible factor 1 and VEGF gene activation; increased production of the angiogenesis inhibitor, endostatin; inhibition of endothelial cell proliferation, migration, and spreading; and induction of endothelial apoptosis. JF - Journal of molecular medicine (Berlin, Germany) AU - Tarnawski, Andrzej S AU - Jones, Michael K AD - Gastroenterology Section, VA Medical Center, 5901 E. Seventh Street, Long Beach, CA 90822, USA. andrzej.tarnawski@med.va.gov Y1 - 2003/10// PY - 2003 DA - October 2003 SP - 627 EP - 636 VL - 81 IS - 10 SN - 0946-2716, 0946-2716 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - DNA-Binding Proteins KW - EGR1 protein, human KW - Early Growth Response Protein 1 KW - Immediate-Early Proteins KW - Transcription Factors KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Animals KW - Endothelium, Vascular -- drug effects KW - Transcription Factors -- antagonists & inhibitors KW - Humans KW - Apoptosis -- drug effects KW - Cell Division -- drug effects KW - Mitogen-Activated Protein Kinases -- antagonists & inhibitors KW - Immediate-Early Proteins -- antagonists & inhibitors KW - DNA-Binding Proteins -- antagonists & inhibitors KW - Neoplasms -- blood supply KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Neovascularization, Pathologic -- prevention & control KW - Neovascularization, Pathologic -- enzymology KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71261880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+medicine+%28Berlin%2C+Germany%29&rft.atitle=Inhibition+of+angiogenesis+by+NSAIDs%3A+molecular+mechanisms+and+clinical+implications.&rft.au=Tarnawski%2C+Andrzej+S%3BJones%2C+Michael+K&rft.aulast=Tarnawski&rft.aufirst=Andrzej&rft.date=2003-10-01&rft.volume=81&rft.issue=10&rft.spage=627&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+medicine+%28Berlin%2C+Germany%29&rft.issn=09462716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-06-21 N1 - Date created - 2003-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quantification of tartrate resistant acid phosphatase distribution in mouse tibiae using image analysis AN - 19616170; 7333598 AB - Tartrate resistant acid phosphatase (TRAP) activity of bone is a suitable biochemical marker for osteoclastic bone resorption. Qualitatively, the histochemical distribution of TRAP has been used to identify osteoclasts responsible for bone resorption; however, there have been few attempts to quantify TRAP localization. We describe a method for evaluating bone resorption by quantifying area percentages of positive TRAP localization using image analysis. Mouse tibiae were paraffin embedded following demineralization in disodium ethylenediamine tetraacetic acid. Longitudinal sections of tibia were cut from 15 levels in the left and the right limbs of six mice (180 sections total) and stained for TRAP distribution. Positive TRAP localization was quantified by pixel area count and reported as a percentage of the total tissue area specified. The 1.85 mm 2 region of interest was placed at the midpoint of the epiphyseal growth plate containing the provisional calcification layer and the primary spongiosa, while excluding cortical bone of each mouse tibia. The percentage of TRAP localization ranged from 0.95 to 1.31% and was not significantly different from level to level or limb to limb in each mouse ( p> 0.100). Within the same region of interest, an osteoclast count along the bone perimeter also was performed. We demonstrated a strong correlation (r 2 =0.903) between the conventional histomorphometric osteoclast index and positive TRAP localization, validating the latter as an alternative method to assess bone resorption. Quantitative analysis of TRAP is significant because it allows statistical comparisons between treatment groups, promotes precise pathological diagnoses and facilitates a reference data base that may aid the study of bone related diseases involving increased bone resorption. JF - Biotechnic and Histochemistry AU - Sawyer, A AU - Lott, P AU - Titrud, J AU - McDonald, J AD - Department of Pathology University of Alabama at Birmingham and Veterans Administration Medical Center Birmingham Alabama 35233 Y1 - 2003/10// PY - 2003 DA - Oct 2003 SP - 271 EP - 278 PB - Taylor & Francis Ltd., 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 78 IS - 5 SN - 1052-0295, 1052-0295 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Biochemical markers KW - Statistics KW - Bone growth KW - Activation-induced cytidine deaminase KW - Epiphyseal growth plate KW - Demineralization KW - Calcification KW - Bone (cortical) KW - Acid phosphatase (tartrate-resistant) KW - Bone resorption KW - Paraffin KW - Osteoclasts KW - Image processing KW - Tibia KW - Databases KW - Limbs KW - Bone diseases KW - Histochemistry KW - W 30910:Imaging KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19616170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnic+and+Histochemistry&rft.atitle=Quantification+of+tartrate+resistant+acid+phosphatase+distribution+in+mouse+tibiae+using+image+analysis&rft.au=Sawyer%2C+A%3BLott%2C+P%3BTitrud%2C+J%3BMcDonald%2C+J&rft.aulast=Sawyer&rft.aufirst=A&rft.date=2003-10-01&rft.volume=78&rft.issue=5&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Biotechnic+and+Histochemistry&rft.issn=10520295&rft_id=info:doi/10.1080%2F10520290310001646668 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Acid phosphatase (tartrate-resistant); Bone resorption; Osteoclasts; Limbs; Image processing; Tibia; Activation-induced cytidine deaminase; Bone growth; Epiphyseal growth plate; Bone (cortical); Calcification; Biochemical markers; Demineralization; Paraffin; Statistics; Histochemistry; Bone diseases; Databases DO - http://dx.doi.org/10.1080/10520290310001646668 ER - TY - JOUR T1 - Bodies in motion: Monitoring daily activity and exercise with motion sensors in people with chronic pulmonary disease AN - 19245542; 5812436 AB - A primary goal of pulmonary rehabilitation is to improve health and life quality by encouraging participants to engage in exercise and to increase daily physical activity. The recent advent of motion sensors, including digital pedometers and accelerometers that measure motion as a continuous variable, have added precision to the measurement of free-living daily activity. Daily activity and exercise are variables of keen interest to proponents of the national health agenda, epidemiologists, clinical researchers, and rehabilitation interventionists. This paper summarizes issues related to conceptualizing and monitoring activity in the rehabilitation setting; reviews motion sensor methodology; compares motion-sensing devices; presents analysis issues and current and potential applications to the pulmonary rehabilitation setting; and gives practical applications and limitations. JF - Journal of Rehabilitation Research and Development AU - Steele, B G AU - Belza, B AU - Cain, K AU - Warms, C AU - Coppersmith, J AU - Howard, J AD - VA Puget Sound Health Care System (111-B), 1660 Columbian Way South, Seattle, WA 98108, USA, bonnie.steele@med.va.gov Y1 - 2003/10// PY - 2003 DA - Oct 2003 SP - 45 EP - 58 VL - 40 IS - 5 SN - 0748-7711, 0748-7711 KW - Physical Education Index KW - Rehabilitation KW - Exercise (prescription) KW - Lungs KW - Diseases KW - Exercise (programs) KW - Movement KW - PE 110:Physical Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19245542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Bodies+in+motion%3A+Monitoring+daily+activity+and+exercise+with+motion+sensors+in+people+with+chronic+pulmonary+disease&rft.au=Steele%2C+B+G%3BBelza%2C+B%3BCain%2C+K%3BWarms%2C+C%3BCoppersmith%2C+J%3BHoward%2C+J&rft.aulast=Steele&rft.aufirst=B&rft.date=2003-10-01&rft.volume=40&rft.issue=5&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Rehabilitation; Movement; Lungs; Diseases; Exercise (prescription); Exercise (programs) ER - TY - JOUR T1 - Effect of ventilation-feedback training on endurance and perceived breathlessness during constant work-rate leg-cycle exercise in patients with COPD AN - 19226587; 5812435 AB - The purpose of this study was to evaluate the efficacy of a unique program of ventilation-feedback training combined with leg-cycle exercise to improve exertional endurance and decrease perceived dyspnea in patients with chronic obstructive pulmonary disease (COPD). Thirty-nine patients (67.5 plus or minus 8.1 yr of age) with moderate to severe COPD (42.6% of predicted forced expiratory volume in 1 s) were randomized to one of three 6-week experimental interventions: ventilation-feedback with exercise (V super(+EX)), exercise only (EX super(ONLY)), or ventilation-feedback only (VF super(ONLY)). At baseline and at 6 weeks, patients completed a constant work-rate leg-cycle ergometer test at 85 percent of maximal power output. There were increases within the groups in exercise duration: 11.5 min (103%), 8.0 min (66%), and 0.4 min (4%) for the VF super(+EX), EX super(ONLY), and VF super(ONLY) groups, respectively. The VF super(ONLY) group experienced no significant within-group changes in selected gas exchange parameters. However, there were significant (p < 0.05) posttraining changes in minute ventilation, tidal volume, breathing frequency (f), and expiratory time (Te) in the VF super(+EX) group, and in f and Te in the EX super(ONLY) group. After completing the training, VF super(+EX) and EX super(ONLY) patients reported less breathlessness and perceived exertion (p < 0.05). The VF super(ONLY) patients' ratings changed in the hypothesized direction but were not significant. Based on these preliminary data, VF super(+EX) and EX super(ONLY) were equally effective in improving leg-cycle exercise tolerance in patients with moderate to severe COPD. JF - Journal of Rehabilitation Research and Development AU - Collins, E G AU - Fehr, L AU - Bammert, C AU - O'Connell, S AU - Laghi, F AU - Hanson, K AU - Hagarty, E AU - Langbein, W E AD - Research and Development (151), Hines VA Hospital, Hines, IL 60141, USA, eileen.collins@med.va.gov Y1 - 2003/10// PY - 2003 DA - Oct 2003 SP - 35 EP - 44 VL - 40 IS - 5 SN - 0748-7711, 0748-7711 KW - Physical Education Index KW - Bicycle ergometry KW - Rehabilitation KW - Respiration KW - Exercise (tolerance) KW - Legs KW - Feedback KW - Cardiorespiratory endurance KW - PE 110:Physical Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19226587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Effect+of+ventilation-feedback+training+on+endurance+and+perceived+breathlessness+during+constant+work-rate+leg-cycle+exercise+in+patients+with+COPD&rft.au=Collins%2C+E+G%3BFehr%2C+L%3BBammert%2C+C%3BO%27Connell%2C+S%3BLaghi%2C+F%3BHanson%2C+K%3BHagarty%2C+E%3BLangbein%2C+W+E&rft.aulast=Collins&rft.aufirst=E&rft.date=2003-10-01&rft.volume=40&rft.issue=5&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Rehabilitation; Feedback; Exercise (tolerance); Respiration; Cardiorespiratory endurance; Bicycle ergometry; Legs ER - TY - JOUR T1 - Recombination Proficiency Influences Frequency and Locus of Mutational Resistance to Linezolid in Enterococcus faecalis AN - 18874799; 5720899 AB - In vitro linezolid resistance was selected at a higher frequency in Enterococcus faecalis JH2-2 than in recombination-deficient E. faecalis UV202. Resistance in JH2-2 was related to accumulated G2576T mutations in 23S rRNA genes, with the least resistance conferred by mutations in two of four copies. UV202 resistance was associated with a G2505A mutation present in a single copy in mutants with different MICs. JF - Antimicrobial Agents & Chemotherapy AU - Lobritz, M AU - Hutton-Thomas, R AU - Marshall, S AU - Rice, L B AD - Medical Service 111(W), VA Medical Center, 10701 East Blvd., Cleveland, OH 44106, louis.rice@med.va.gov Y1 - 2003/10// PY - 2003 DA - Oct 2003 SP - 3318 EP - 3320 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 47 IS - 10 SN - 0066-4804, 0066-4804 KW - linezolid KW - Microbiology Abstracts B: Bacteriology KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18874799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Recombination+Proficiency+Influences+Frequency+and+Locus+of+Mutational+Resistance+to+Linezolid+in+Enterococcus+faecalis&rft.au=Lobritz%2C+M%3BHutton-Thomas%2C+R%3BMarshall%2C+S%3BRice%2C+L+B&rft.aulast=Lobritz&rft.aufirst=M&rft.date=2003-10-01&rft.volume=47&rft.issue=10&rft.spage=3318&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.47.10.3318-3320.2003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1128/AAC.47.10.3318-3320.2003 ER - TY - JOUR T1 - Comparison of breathing patterns during exercise in patients with obstructive and restrictive ventilatory abnormalities AN - 17696203; 5980825 AB - Patients with obstructive and restrictive ventilatory abnormalities suffer from exercise intolerance and dyspnea. Breathing pattern components (volume, flow, and timing) during incremental exercise may provide further insight in the role played by dynamic hyperinflation in the genesis of dyspnea. This study analyzed the breathing patterns of patients with obstructive and restrictive ventilatory abnormalities during incremental exercise. It also explored breathing pattern components with dyspnea at maximum oxygen uptake (VO sub(2) max). Twenty patients, thirteen obstructive patients (forced expiratory volume 38% plus or minus 13% predicted, forced expiratory volume in 1 s/forced vital capacity ratio 39 plus or minus 8%), and seven restrictive patients (forced vital capacity 55 plus or minus 16% predicted, forced expiratory volume in 1 s/forced vital capacity ratio 84% plus or minus 11%) performed symptom-limited incremental exercise tests on a cycle ergometer with breath-by-breath determination of ventilation and gas exchange parameters. Breathing patterns were analyzed at baseline, 20, 40, 60, 80, and 100 percent of VO sub(2) max. Dyspnea was measured at end-exercise with a 100 mm visual analogue scale. The timing ratio of inspiratory to expiratory time (T sub(I)/T sub(E)) and the flow ratio of inspiratory flow to expiratory flow ratio (V sub(I)/V sub(E)) were different (p < 0.008) between obstructive and restrictive patients at all exercise intensity levels. The timing components of expiratory time (T sub(E)) and inspiratory time to total time (T sub(I)T sub(TOT)) were significantly different (p < 0.008) at baseline and maximum exercise. Dyspnea scores were not significantly different. For obstructive patients, correlations were noted between T sub(I)/T sub(E), V sub(I)/V sub(E), T sub(I)T sub(TOT) and dyspnea (p < 0.05). Breathing pattern-timing components, specifically T sub(I)/T sub(E), in patients with obstructive and restrictive ventilatory abnormalities during exercise provided further insight into the pathophysiology of the two conditions and the contribution of dynamic hyperinflation to dyspnea. JF - Journal of Rehabilitation Research and Development AU - Nield, M AU - Arora, A AU - Dracup, K AU - Hoo, GWS AU - Cooper, C B AD - VA West Los Angeles Healthcare Center, Pulmonary Section 111Q, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA, margaret.nield@med.va.gov Y1 - 2003/10// PY - 2003 DA - Oct 2003 SP - 407 EP - 414 VL - 40 IS - 5 SN - 0748-7711, 0748-7711 KW - Physical Education Index KW - Rehabilitation KW - Pulmonary ventilation KW - Respiration KW - Exercise (tolerance) KW - Exercise (effects) KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17696203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Comparison+of+breathing+patterns+during+exercise+in+patients+with+obstructive+and+restrictive+ventilatory+abnormalities&rft.au=Nield%2C+M%3BArora%2C+A%3BDracup%2C+K%3BHoo%2C+GWS%3BCooper%2C+C+B&rft.aulast=Nield&rft.aufirst=M&rft.date=2003-10-01&rft.volume=40&rft.issue=5&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=07487711&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Exercise (tolerance); Respiration; Pulmonary ventilation; Rehabilitation; Exercise (effects) ER - TY - JOUR T1 - Dexamethasone induces caspase activation in murine osteoblastic MC3T3-E1 cells. AN - 73652671; 12972296 AB - Glucocorticoids are widely used as anti-inflammatory and chemotherapeutic agents. However, prolonged use of glucocorticoids leads to osteoporosis. This study was designed to examine the mechanism of dexamethasone (DEX)-induced apoptosis in murine osteoblastic MC3T3-E1 cells. Total RNA was extracted from MC3T3-E1 cells treated with 10(-7) M DEX for 6 h. DEX exerted a variety of effects on apoptotic gene expression in osteoblasts. Ribonuclease protection assays (RPA) revealed that DEX upregulated mRNA levels of caspases-1, -3, -6, -8, -11, -12, and bcl-XL. Western blot analysis showed enhanced processing of these caspases, with the appearance of their activated enzymes 8 h after DEX treatment. In addition, DEX also induced the activation of caspase-9. DEX elevated the levels of cleaved poly(ADP-ribose) polymerase and lamin A, a caspase-3 and a caspase-6 substrate, respectively. Expression of bcl-XL protein level was upregulated by DEX. Cytochrome c release was detected in the cytosol of DEX-treated cells. Furthermore, caspase-3 enzyme activity was elevated by 2-fold after DEX treatment for 7 h. Finally, early apoptotic cells were detected in cells treated with DEX for 3 h. Our results demonstrate that DEX-induced apoptosis involves gene activation of a number of caspases. JF - Biochimica et biophysica acta AU - Chua, Chu Chang AU - Chua, Balvin H L AU - Chen, Zhongyi AU - Landy, Cathy AU - Hamdy, Ronald C AD - Osteoporosis Center, James H. Quillen College of Medicine, East Tennessee State University, and Veterans Affairs Medical Center, Box 70432, Johnson City, TN 37614, USA. chua.chu@med.va.gov Y1 - 2003/09/23/ PY - 2003 DA - 2003 Sep 23 SP - 79 EP - 85 VL - 1642 IS - 1-2 SN - 0006-3002, 0006-3002 KW - Bcl2l1 protein, mouse KW - 0 KW - Cytochrome c Group KW - Lamin Type A KW - Proteins KW - Proto-Oncogene Proteins c-bcl-2 KW - RNA, Messenger KW - bcl-X Protein KW - Dexamethasone KW - 7S5I7G3JQL KW - Parp1 protein, mouse KW - EC 2.4.2.30 KW - Poly (ADP-Ribose) Polymerase-1 KW - Poly(ADP-ribose) Polymerases KW - Caspases KW - EC 3.4.22.- KW - Index Medicus KW - Animals KW - Lamin Type A -- drug effects KW - RNA, Messenger -- drug effects KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Proto-Oncogene Proteins c-bcl-2 -- drug effects KW - Up-Regulation -- drug effects KW - Osteoporosis -- genetics KW - Cytochrome c Group -- metabolism KW - Osteoporosis -- enzymology KW - Osteoporosis -- chemically induced KW - Reaction Time -- drug effects KW - Lamin Type A -- metabolism KW - Mice KW - Up-Regulation -- genetics KW - Proteins -- metabolism KW - Reaction Time -- physiology KW - Transcriptional Activation KW - Proteins -- drug effects KW - Gene Expression Regulation, Enzymologic -- genetics KW - RNA, Messenger -- metabolism KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Cytochrome c Group -- drug effects KW - Osteoblasts -- drug effects KW - Osteoblasts -- enzymology KW - Enzyme Induction -- drug effects KW - Dexamethasone -- pharmacology KW - Apoptosis -- physiology KW - Apoptosis -- drug effects KW - Caspases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73652671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Dexamethasone+induces+caspase+activation+in+murine+osteoblastic+MC3T3-E1+cells.&rft.au=Chua%2C+Chu+Chang%3BChua%2C+Balvin+H+L%3BChen%2C+Zhongyi%3BLandy%2C+Cathy%3BHamdy%2C+Ronald+C&rft.aulast=Chua&rft.aufirst=Chu&rft.date=2003-09-23&rft.volume=1642&rft.issue=1-2&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-10-28 N1 - Date created - 2003-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of MK-801-elicited mouse popping behavior by galantamine is complex and dose-dependent. AN - 73608391; 12941437 AB - The ability of phencyclidine (PCP), a noncompetitive antagonist of NMDA receptor-mediated neurotransmission, to precipitate a schizophreniform psychosis in susceptible individuals is consistent with the hypothesized pathologic occurrence of NMDA receptor hypofunction in this disorder. Because the psychosis caused by PCP resembles schizophrenia in all of the relevant domains of psychopathology, investigators have sought to characterize animal models of NMDA receptor hypofunction. MK-801 (dizocilpine) binds to the same hydrophobic channel domain in the NMDA receptor-associated ionophore as PCP, and has been shown to elicit intense irregular episodes of jumping behavior in mice, termed "popping." MK-801-elicited mouse popping is an animal model of NMDA receptor hypofunction that has been used to screen novel candidate compounds for the treatment of schizophrenia. Recently, a selective abnormality in the transduction of the acetylcholine signal at the level of the alpha 7 nicotinic receptor has been described in schizophrenia. The existence of a nicotinic cholinergic abnormality in schizophrenia has stimulated interest in a potential therapeutic role for positive allosteric modulation of nicotinic receptors. Galantamine is a compound that possesses two interesting properties: inhibition of acetylcholinesterase and positive allosteric modulation of nicotinic neurotransmission. Theoretically, galantamine would be expected to increase the efficiency or likelihood that acetylcholine will promote channel opening and ionic conductance at nicotinic receptors. As expected, in the current investigation statistically significant popping behavior was elicited by MK-801 in mice (T(22) = 2.16, P < 0.05). This MK-801-elicited popping was significantly attenuated by 100 mg/kg of galantamine (T(22) = 2.24, P < 0.05). The data show that nicotinic interventions can influence NMDA receptor-mediated neurotransmission in the intact mouse. JF - Life sciences AU - Deutsch, Stephen I AU - Rosse, Richard B AU - Billingslea, Eddie N AU - Bellack, Alan S AU - Mastropaolo, John AD - Mental Health Service Line, Veterans Integrated Service Network (VISN) 5, 849 International Drive, Suite 275, Linthicum, MD 21090, USA. Stephen.Deutsch@med.va.gov Y1 - 2003/09/19/ PY - 2003 DA - 2003 Sep 19 SP - 2355 EP - 2361 VL - 73 IS - 18 SN - 0024-3205, 0024-3205 KW - Neuroprotective Agents KW - 0 KW - Parasympathomimetics KW - Galantamine KW - 0D3Q044KCA KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - Index Medicus KW - Schizophrenia KW - Injections, Intraperitoneal KW - Animals KW - Disease Models, Animal KW - Mice KW - Drug Antagonism KW - Image Processing, Computer-Assisted KW - Male KW - Behavior, Animal -- drug effects KW - Parasympathomimetics -- pharmacology KW - Neuroprotective Agents -- administration & dosage KW - Galantamine -- administration & dosage KW - Galantamine -- pharmacology KW - Behavior, Animal -- physiology KW - Dizocilpine Maleate -- administration & dosage KW - Parasympathomimetics -- administration & dosage KW - Neuroprotective Agents -- pharmacology KW - Dizocilpine Maleate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73608391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Modulation+of+MK-801-elicited+mouse+popping+behavior+by+galantamine+is+complex+and+dose-dependent.&rft.au=Deutsch%2C+Stephen+I%3BRosse%2C+Richard+B%3BBillingslea%2C+Eddie+N%3BBellack%2C+Alan+S%3BMastropaolo%2C+John&rft.aulast=Deutsch&rft.aufirst=Stephen&rft.date=2003-09-19&rft.volume=73&rft.issue=18&rft.spage=2355&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-09-22 N1 - Date created - 2003-08-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment of essential blepharospasm with quetiapine. AN - 85378526; pmid-14502683 AB - A 69-year-old male with blepharospasm unresponsive to several medications who was successfully treated with quetiapine is described. His symptoms were largely alleviated by low doses, but he experienced sedation, which permitted him to take the medication at bedtime only.Copyright 2003 Movement Disorder Society JF - Movement disorders : official journal of the Movement Disorder Society AU - Reeves, Roy R AU - Liberto, Vincent AD - University of Mississippi School of Medicine, Jackson, Mississippi 39216, USA. roy.reeves@med.va.gov Y1 - 2003/09// PY - 2003 DA - Sep 2003 SP - 1072 EP - 1073 VL - 18 IS - 9 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - *Antipsychotic Agents: therapeutic use KW - *Blepharospasm: drug therapy KW - *Dibenzothiazepines: therapeutic use KW - Humans KW - Male KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85378526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Treatment+of+essential+blepharospasm+with+quetiapine.&rft.au=Reeves%2C+Roy+R%3BLiberto%2C+Vincent&rft.aulast=Reeves&rft.aufirst=Roy&rft.date=2003-09-01&rft.volume=18&rft.issue=9&rft.spage=1072&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Right-sided vagus nerve stimulation reduces generalized seizure severity in rats as effectively as left-sided. AN - 75754157; 14529948 AB - As currently utilized, vagus nerve stimulation (VNS) is applied to the cervical trunk of the left vagus nerve to suppress seizures clinically. Demonstration that VNS can also reduce seizure severity when electrodes are placed on the right cervical vagus nerve in rats would provide empirical evidence that the antiepileptic effects of VNS are not an exclusive property of the left vagus nerve. Rats were implanted with a custom cuff electrode on either the left or right cervical vagus nerve. Two days later, continuous VNS was begun in half the rats with left-sided and half with right-sided electrodes. The remaining rats were connected to the stimulator, but did not receive VNS. After 30s, pentylenetetrazole (PTZ) was administered systemically and seizures were rated by a blinded observer. The PTZ test was repeated two days later, with VNS administered to the previously unstimulated rats, while the others received no stimulation. VNS significantly reduced the severity of PTZ-induced seizures in rats regardless of the side of stimulation as compared to their no-VNS (control condition) seizure severity. No significant differences in efficacy existed based on the side of stimulation. These results indicate that right-sided VNS in rats is just as effective as left-sided VNS, suggesting that fibers necessary for seizure suppression are not unique to the left vagus nerve. JF - Epilepsy research AU - Krahl, Scott E AU - Senanayake, Shayani S AU - Handforth, Adrian AD - Neurology Service, VA Greater Los Angeles Healthcare System, and Division of Neurosurgery, University of California, Los Angeles, USA. scott.krahl@med.va.gov Y1 - 2003/09// PY - 2003 DA - September 2003 SP - 1 EP - 4 VL - 56 IS - 1 SN - 0920-1211, 0920-1211 KW - Pentylenetetrazole KW - WM5Z385K7T KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Electrodes KW - Disease Models, Animal KW - Vagus Nerve -- physiology KW - Vagus Nerve -- radiation effects KW - Epilepsy, Generalized -- chemically induced KW - Epilepsy, Generalized -- therapy KW - Functional Laterality -- physiology KW - Functional Laterality -- radiation effects KW - Electric Stimulation Therapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75754157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsy+research&rft.atitle=Right-sided+vagus+nerve+stimulation+reduces+generalized+seizure+severity+in+rats+as+effectively+as+left-sided.&rft.au=Krahl%2C+Scott+E%3BSenanayake%2C+Shayani+S%3BHandforth%2C+Adrian&rft.aulast=Krahl&rft.aufirst=Scott&rft.date=2003-09-01&rft.volume=56&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Epilepsy+research&rft.issn=09201211&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-09-13 N1 - Date created - 2003-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Continuous spinal anaesthesia: what's new and what's not. AN - 75747085; 14529010 AB - Continuous spinal anaesthesia combines the advantages of single-dose spinal anaesthesia, rapid onset and a high degree of success, with those of a continuous technique. The introduction of micro-catheters invigorated interest in the technique and allowed its expansion to additional populations and surgical procedures. However, multiple cases of cauda equina syndrome associated with micro-catheters and (primarily) hyperbaric lidocaine solution led to withdrawal of micro-catheters from the US market, casting doubt over the safety of continuous spinal anaesthesia as a whole. A decade after these events it is possible to look back at the experience with continuous spinal anaesthesia for operative anaesthesia and postoperative analgesia and to compare it with the available alternatives. From this perspective, continuous spinal anaesthesia remains a useful and safe technique. Future research should focus on the comparison of continuous spinal anaesthesia with the combined spinal/epidural technique and the use of newer spinal agents. JF - Best practice & research. Clinical anaesthesiology AU - Bevacqua, Brian K AD - University of Wisconsin School of Medicine, William S. Middleton VAMC (112A), Anesthesiology Service, 2500 Overlook Terrace, Madison, WI 53705, USA. brian.bevacqua2@med.va.gov Y1 - 2003/09// PY - 2003 DA - September 2003 SP - 393 EP - 406 VL - 17 IS - 3 SN - 1521-6896, 1521-6896 KW - Anesthetics, Local KW - 0 KW - Index Medicus KW - Pain, Postoperative -- prevention & control KW - Humans KW - Anesthesia, Epidural -- adverse effects KW - Anesthesia, Epidural -- methods KW - Anesthesia, Spinal -- methods KW - Anesthetics, Local -- administration & dosage KW - Anesthesia, Spinal -- adverse effects KW - Anesthetics, Local -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75747085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Best+practice+%26+research.+Clinical+anaesthesiology&rft.atitle=Continuous+spinal+anaesthesia%3A+what%27s+new+and+what%27s+not.&rft.au=Bevacqua%2C+Brian+K&rft.aulast=Bevacqua&rft.aufirst=Brian&rft.date=2003-09-01&rft.volume=17&rft.issue=3&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Best+practice+%26+research.+Clinical+anaesthesiology&rft.issn=15216896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-11 N1 - Date created - 2003-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Trazodone for erectile dysfunction: a systematic review and meta-analysis. AN - 73646934; 12930437 AB - To determine the efficacy and safety of trazodone in the treatment of erectile dysfunction (ED) in a meta-analysis. The data sources used were Medline and the Cochrane Library databases (January 1966 to May 2002), bibliographies of retrieved articles and review articles, and conference proceedings and abstracts. Trials were eligible for inclusion in the review if they included men with ED, compared trazodone with a control, were randomized, of > or = 7 days' duration and assessed clinically relevant outcomes. Two reviewers independently evaluated study quality and extracted data in a standardized fashion. Six trials (comprising 396 men) met the inclusion criteria; they consisted of heterogeneous populations, were small, brief and in some cases methodologically weak. Three of the six trials showed an apparently clinically meaningful benefit of trazodone for ED compared with placebo, the differences being statistically significant in two. In pooled results, trazodone monotherapy appeared more likely than placebo to lead to a 'positive treatment response', although this difference was not statistically significant (37% vs 20%; relative benefit increase, 1.6; 95% confidence interval, CI, 0.8-3.3). Subgroup analyses suggested that men with psychogenic ED might be more likely to benefit from trazodone than those with mixed or physiological ED. The efficacy of trazodone also appeared greater at higher doses (150-200 vs 50 mg/day). Men randomized to trazodone were not significantly more likely than those receiving placebo to withdraw for any reason or for an adverse event, or to have specific adverse events, but wide CIs could not exclude a greater risk of these adverse outcomes with trazodone. Specific adverse events with trazodone included dry mouth (19%), sedation (16%), dizziness (16%) and fatigue (15%). Trazodone may be helpful in men with ED, possibly more so at higher doses, and in men with psychogenic ED. Future high-quality trials should compare trazodone with placebo and other therapies in men with depression and psychogenic ED. JF - BJU international AU - Fink, H A AU - MacDonald, R AU - Rutks, I R AU - Wilt, T J AD - Geriatric Research Education and Clinical Center, Section of General Internal Medicine, VA Medical Center, Minneapolis, USA. howard.fink@med.va.gov Y1 - 2003/09// PY - 2003 DA - September 2003 SP - 441 EP - 446 VL - 92 IS - 4 SN - 1464-4096, 1464-4096 KW - Anti-Anxiety Agents KW - 0 KW - Antidepressive Agents, Second-Generation KW - Trazodone KW - YBK48BXK30 KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Male KW - Trazodone -- therapeutic use KW - Antidepressive Agents, Second-Generation -- adverse effects KW - Antidepressive Agents, Second-Generation -- therapeutic use KW - Erectile Dysfunction -- psychology KW - Trazodone -- adverse effects KW - Erectile Dysfunction -- drug therapy KW - Anti-Anxiety Agents -- therapeutic use KW - Anti-Anxiety Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73646934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BJU+international&rft.atitle=Trazodone+for+erectile+dysfunction%3A+a+systematic+review+and+meta-analysis.&rft.au=Fink%2C+H+A%3BMacDonald%2C+R%3BRutks%2C+I+R%3BWilt%2C+T+J&rft.aulast=Fink&rft.aufirst=H&rft.date=2003-09-01&rft.volume=92&rft.issue=4&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=BJU+international&rft.issn=14644096&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-12-15 N1 - Date created - 2003-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 133Xe contamination found in internal bacteria filter of xenon ventilation system. AN - 73641522; 12968050 AB - We report on (133)Xe contamination found in the reusable internal bacteria filter of our xenon ventilation system. Internal bacteria filters (n = 6) were evaluated after approximately 1 mo of normal use. The ventilation system was evacuated twice to eliminate (133)Xe in the system before removal of the filter. Upon removal, the filter was monitored using a survey meter with an energy-compensated probe and was imaged on a scintillation camera. The filter was monitored and imaged over several days and was stored in a fume hood. Estimated (133)Xe activity in each filter immediately after removal ranged from 132 to 2,035 kBq (3.6-55.0 micro Ci), based on imaging. Initial surface radiation levels ranged from 0.4 to 4.5 micro Sv/h (0.04-0.45 mrem/h). The (133)Xe activity did not readily leave the filter over time (i.e., time to reach half the counts of the initial decay-corrected image ranged from 72 h). The majority of the image counts (approximately 70%) were seen in 2 distinctive areas in the filter. They corresponded to sites where the manufacturer used polyurethane adhesive to attach the fiberglass filter medium to the filter housing. (133)Xe contamination within the reusable internal bacteria filter of our ventilation system was easily detected by a survey meter and imaging. Although initial activities and surface radiation levels were low, radiation safety practices would dictate that a (133)Xe-contaminated bacteria filter be stored preferably in a fume hood until it cannot be distinguished from background before autoclaving or disposal. JF - Journal of nuclear medicine technology AU - Hackett, Michael T AU - Collins, Judith A AU - Wierzbinski, Rebecca S AD - Radiation Safety Office and Nuclear Medicine Service, Department of Veterans Affairs Medical Center, Lexington, Kentucky 40502-2236, USA. michael.hackett@med.va.gov Y1 - 2003/09// PY - 2003 DA - September 2003 SP - 170 EP - 172 VL - 31 IS - 3 SN - 0091-4916, 0091-4916 KW - Radioactive Pollutants KW - 0 KW - Xenon Radioisotopes KW - Index Medicus KW - Radiation Protection -- methods KW - Decontamination -- instrumentation KW - Bacteria -- isolation & purification KW - Radiometry -- methods KW - Administration, Inhalation KW - Ultrafiltration -- instrumentation KW - Drug Delivery Systems -- instrumentation KW - Ventilators, Mechanical KW - Xenon Radioisotopes -- administration & dosage KW - Radioactive Pollutants -- analysis KW - Equipment Failure Analysis -- methods KW - Equipment Contamination -- prevention & control KW - Xenon Radioisotopes -- analysis KW - Equipment Failure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73641522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+technology&rft.atitle=133Xe+contamination+found+in+internal+bacteria+filter+of+xenon+ventilation+system.&rft.au=Hackett%2C+Michael+T%3BCollins%2C+Judith+A%3BWierzbinski%2C+Rebecca+S&rft.aulast=Hackett&rft.aufirst=Michael&rft.date=2003-09-01&rft.volume=31&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+technology&rft.issn=00914916&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-12 N1 - Date created - 2003-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Feasibility of a skills training approach to reduce substance dependence among individuals with schizophrenia. AN - 73624153; 12954948 AB - A novel treatment for persons who have both schizophrenia and substance abuse was evaluated by incorporating cognitive-behavioral drug relapse prevention strategies into a skills training method originally developed to teach social and independent living skills to patients with schizophrenia. Thirty-four of 56 patients completed treatment and a three-month follow-up assessment. Participants learned substance abuse management skills and reported that they found the treatment relevant, useful, and satisfying, and their drug use decreased. Improvements were noted in medication adherence, psychiatric symptoms, and quality of life. This manual-driven therapy may play an important role in the treatment of substance abuse among patients with schizophrenia. JF - Psychiatric services (Washington, D.C.) AU - Shaner, Andrew AU - Eckman, Thad AU - Roberts, Lisa J AU - Fuller, Thomas AD - Department of Psychiatry (116A), West Los Angeles VA Medical Center, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA. andrew.shaner@med.va.gov Y1 - 2003/09// PY - 2003 DA - September 2003 SP - 1287 EP - 1289 VL - 54 IS - 9 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - Feasibility Studies KW - Patient Compliance KW - Humans KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - Program Evaluation KW - Middle Aged KW - Male KW - Los Angeles KW - Female KW - Hospitals, Veterans KW - Patient Education as Topic -- methods KW - Veterans -- psychology KW - Schizophrenia -- diagnosis KW - Substance-Related Disorders -- complications KW - Self Efficacy KW - Schizophrenia -- drug therapy KW - Veterans -- education KW - Schizophrenia -- complications KW - Secondary Prevention KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73624153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Feasibility+of+a+skills+training+approach+to+reduce+substance+dependence+among+individuals+with+schizophrenia.&rft.au=Shaner%2C+Andrew%3BEckman%2C+Thad%3BRoberts%2C+Lisa+J%3BFuller%2C+Thomas&rft.aulast=Shaner&rft.aufirst=Andrew&rft.date=2003-09-01&rft.volume=54&rft.issue=9&rft.spage=1287&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-06 N1 - Date created - 2003-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Randomized controlled trial of clopidogrel plus aspirin to prevent hemodialysis access graft thrombosis. AN - 73588119; 12937308 AB - Thrombosis of hemodialysis vascular access grafts represents a major medical and economic burden. Experimental and clinical models suggest a role for antiplatelet agents in the prevention of thrombosis. The study was designed to determine the efficacy of the combination of aspirin and clopidogrel in the prevention of graft thrombosis. The study was a randomized, double-blind trial conducted at 30 hemodialysis units at Veterans Affairs medical centers. Participants undergoing hemodialysis with a polytetrafluoroethylene graft in the arm were randomized to receive either double placebos or aspirin (325 mg) and clopidogrel (75 mg) daily. Participants were to be monitored while receiving study medications for a minimum of 2 yr. The study was stopped after randomization of 200 participants, as recommended by the Data Safety and Monitoring Board because of a significantly increased risk of bleeding among the participants receiving aspirin and clopidogrel therapy. The cumulative incidence of bleeding events was significantly greater for those participants, compared with participants receiving placebos [hazard ratio, 1.98; 95% confidence interval (CI), 1.19 to 3.28; P = 0.007]. Twenty-three participants in the placebo group and 44 participants in the active treatment group experienced a bleeding event (P = 0.006). There was no significant benefit of active treatment in the prevention of thrombosis (hazard ratio, 0.81; 95% CI, 0.47 to 1.40; P = 0.45), although there was a trend toward a benefit among participants who had not experienced previous graft thrombosis (hazard ratio, 0.52; 95% CI, 0.22 to 1.26; P = 0.14). In the hemodialysis population, therapy with aspirin and clopidogrel was associated with a significantly increased risk of bleeding and probably would not result in a reduced frequency of graft thrombosis. JF - Journal of the American Society of Nephrology : JASN AU - Kaufman, James S AU - O'Connor, Theresa Z AU - Zhang, Jane Hongyuan AU - Cronin, Robert E AU - Fiore, Louis D AU - Ganz, Michael B AU - Goldfarb, David S AU - Peduzzi, Peter N AU - Veterans Affairs Cooperative Study Group on Hemodialysis Access Graft Thrombosis AD - Department of Veterans Affairs Boston Healthcare System and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02130, USA. james.kaufman@med.va.gov ; Veterans Affairs Cooperative Study Group on Hemodialysis Access Graft Thrombosis Y1 - 2003/09// PY - 2003 DA - September 2003 SP - 2313 EP - 2321 VL - 14 IS - 9 SN - 1046-6673, 1046-6673 KW - Platelet Aggregation Inhibitors KW - 0 KW - Polytetrafluoroethylene KW - 9002-84-0 KW - clopidogrel KW - A74586SNO7 KW - Ticlopidine KW - OM90ZUW7M1 KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Drug Therapy, Combination KW - Double-Blind Method KW - Humans KW - Kidney Failure, Chronic -- therapy KW - Aged KW - Polytetrafluoroethylene -- adverse effects KW - Middle Aged KW - Renal Dialysis KW - Male KW - Female KW - Thrombosis -- prevention & control KW - Ticlopidine -- analogs & derivatives KW - Aspirin -- administration & dosage KW - Catheters, Indwelling -- adverse effects KW - Thrombosis -- etiology KW - Ticlopidine -- administration & dosage KW - Platelet Aggregation Inhibitors -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73588119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=Randomized+controlled+trial+of+clopidogrel+plus+aspirin+to+prevent+hemodialysis+access+graft+thrombosis.&rft.au=Kaufman%2C+James+S%3BO%27Connor%2C+Theresa+Z%3BZhang%2C+Jane+Hongyuan%3BCronin%2C+Robert+E%3BFiore%2C+Louis+D%3BGanz%2C+Michael+B%3BGoldfarb%2C+David+S%3BPeduzzi%2C+Peter+N%3BVeterans+Affairs+Cooperative+Study+Group+on+Hemodialysis+Access+Graft+Thrombosis&rft.aulast=Kaufman&rft.aufirst=James&rft.date=2003-09-01&rft.volume=14&rft.issue=9&rft.spage=2313&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-04 N1 - Date created - 2003-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acrylonitrile produces transient cochlear function loss and potentiates permanent noise-induced hearing loss. AN - 73561698; 12832658 AB - There is growing evidence that agents that produce oxidative stress in the cochlea have significant ototoxic potential by themselves and can potentiate noise-induced hearing loss as well. Acrylonitrile (ACN) metabolism entails conjugation with glutathione, resulting in rapid and pronounced depletion of this important antioxidant in many organs including brain, liver, and kidney. ACN metabolism also results in cyanide (CN) formation through a secondary oxidative pathway. The results of two physiological experiments are reported here. First, the acute effects of ACN (50 mg/kg sc) on auditory sensitivity are assessed using a within subject study. In the second study, persistent effects of ACN alone (50 mg/kg, sc and 2 x 50 mg/kg, sc) and ACN in combination with noise exposure (8 h, 108 dB octave-band noise) are evaluated using threshold sensitivity as the dependent measure. Auditory threshold shift and absolute thresholds were determined using the compound action potential (CAP) amplitude. Acute ACN administration produces a loss in auditory threshold sensitivity that reached a maximum 10-20 min following sc injection. Auditory thresholds returned to control levels 75-100 min following exposure. In the study of permanent auditory threshold shifts, ACN plus noise increased auditory threshold impairment relative to rats receiving noise only when thresholds were assessed 3 weeks following exposure. ACN by itself did not produce permanent threshold impairment 3 weeks following administration. Assays were undertaken in separate groups of rats to track the elevation in blood CN and the depletion of total glutathione in cochlea, brain, and liver following ACN treatment. Systemic blood CN levels were not significantly elevated until 60-120 min following injection, and cochlear glutathione levels showed significant depletion as little as 15 min after injection and remained depressed for about 4 h. The results confirm the prediction that ACN is acutely ototoxic and can enhance noise-induced hearing loss. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Fechter, Laurence D AU - Klis, Sjaak F L AU - Shirwany, Najeeb A AU - Moore, Toby G AU - Rao, Deepa Bandi AD - Oklahoma Center for Toxicology, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA. larry.fechter@med.va.gov Y1 - 2003/09// PY - 2003 DA - September 2003 SP - 117 EP - 123 VL - 75 IS - 1 SN - 1096-6080, 1096-6080 KW - Cyanides KW - 0 KW - Glutathione KW - GAN16C9B8O KW - Acrylonitrile KW - MP1U0D42PE KW - Index Medicus KW - Rats KW - Animals KW - Rats, Long-Evans KW - Cyanides -- blood KW - Cochlea -- metabolism KW - Auditory Threshold KW - Glutathione -- metabolism KW - Liver -- metabolism KW - Brain -- metabolism KW - Time Factors KW - Noise -- adverse effects KW - Male KW - Cochlear Diseases -- etiology KW - Cochlear Diseases -- prevention & control KW - Hearing Loss, Noise-Induced -- etiology KW - Acrylonitrile -- toxicity KW - Hearing Loss, Noise-Induced -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73561698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Acrylonitrile+produces+transient+cochlear+function+loss+and+potentiates+permanent+noise-induced+hearing+loss.&rft.au=Fechter%2C+Laurence+D%3BKlis%2C+Sjaak+F+L%3BShirwany%2C+Najeeb+A%3BMoore%2C+Toby+G%3BRao%2C+Deepa+Bandi&rft.aulast=Fechter&rft.aufirst=Laurence&rft.date=2003-09-01&rft.volume=75&rft.issue=1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-02 N1 - Date created - 2003-08-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacologic treatment of posttraumatic stress disorder: a focus on antipsychotic use. AN - 71544871; 14971865 AB - To review the literature on the pharmacologic treatment of posttraumatic stress disorder (PTSD), with a focus on reports of antipsychotic use for this illness. A MEDLINE search (1966-Oct 2002) for English only articles about pharmacologic treatment of PTSD. Antipsychotic medications are being used with some frequency for PTSD. There are few studies and scant evidence to recommend the traditional antipsychotics. There are a number of reports (mostly case reports and open trials) in which atypical antipsychotics improved sleep and decreased the frequency of nightmares and flashbacks. Some studies showed global improvement across symptom clusters. The newer atypical antipsychotics show promise for the treatment of PTSD, mainly ameliorating intrusive symptoms. The paucity of double-blind studies prevents firm conclusions, however, this class of medications may be useful particularly for refractory symptoms. JF - Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists AU - Ahearn, Eileen P AU - Krohn, Amy AU - Connor, Kathryn M AU - Davidson, Jonathan R T AD - William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705-2286, USA. eileen.ahearn@med.va.gov PY - 2003 SP - 193 EP - 201 VL - 15 IS - 3-4 SN - 1040-1237, 1040-1237 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Sleep -- drug effects KW - Humans KW - Dreams -- drug effects KW - Treatment Outcome KW - Clinical Trials as Topic KW - Drug Utilization -- statistics & numerical data KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Antipsychotic Agents -- administration & dosage KW - Combat Disorders -- psychology KW - Stress Disorders, Post-Traumatic -- psychology KW - Combat Disorders -- drug therapy KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Combat Disorders -- diagnosis KW - Combat Disorders -- epidemiology KW - Antipsychotic Agents -- adverse effects KW - Stress Disorders, Post-Traumatic -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71544871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+clinical+psychiatry+%3A+official+journal+of+the+American+Academy+of+Clinical+Psychiatrists&rft.atitle=Pharmacologic+treatment+of+posttraumatic+stress+disorder%3A+a+focus+on+antipsychotic+use.&rft.au=Ahearn%2C+Eileen+P%3BKrohn%2C+Amy%3BConnor%2C+Kathryn+M%3BDavidson%2C+Jonathan+R+T&rft.aulast=Ahearn&rft.aufirst=Eileen&rft.date=2003-09-01&rft.volume=15&rft.issue=3-4&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Annals+of+clinical+psychiatry+%3A+official+journal+of+the+American+Academy+of+Clinical+Psychiatrists&rft.issn=10401237&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-10 N1 - Date created - 2004-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Suicide attempts among veterans seeking treatment for pathological gambling. AN - 71394298; 14628978 AB - There is little information in the scientific literature regarding the suicide attempts of pathological gamblers, even though studies of problem gamblers have found that completed suicide, suicide attempts, and suicidal ideation are common outcomes related to gambling behavior. There has been no attempt in previous studies to identify the contributions of comorbid conditions, such as substance abuse, to the suicide attempts of pathological gamblers. A retrospective chart review was completed for all consecutive admissions (N = 114) to the Gambling Treatment Program of the Louis Stokes VA Medical Center over a 12-month period (September 2000-September 2001). All subjects met DSM-IV criteria for pathological gambling. Relevant information was obtained from the admission history and physical examination, as well as a variety of self-report questionnaires and structured instruments. Forty-five patients (39.5%) reported that they had made a suicide attempt at some time in their lives. The most common method was overdose. Sixty-four percent of attempters reported that their most recent attempt was related to gambling. Forty-two percent of gamblers with a history of alcohol dependence and 58.8% of those with a history of drug dependence had a history of suicide attempts. Mean impulsivity scores differentiated suicide attempters from nonattempters among gamblers with a history of drug and/or alcohol dependence. Severity of psychiatric symptoms and family problems on admission was related to a history of suicide attempts. Pathological gamblers have high rates of attempted suicide. They are highly impulsive and suffer from high rates of comorbid psychiatric conditions as well as social disruptions. A combination of these risk factors very likely contributes to their potential for suicidal behavior. JF - The Journal of clinical psychiatry AU - Kausch, Otto AD - Louis Stokes VA Medical Center, Brecksville Division, Brecksville, OH 44141, USA. Otto.Kausch@med.va.gov Y1 - 2003/09// PY - 2003 DA - September 2003 SP - 1031 EP - 1038 VL - 64 IS - 9 SN - 0160-6689, 0160-6689 KW - Index Medicus KW - United States KW - Humans KW - Retrospective Studies KW - Aged KW - Personality Inventory KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Comorbidity KW - Cross-Sectional Studies KW - Alcoholism -- epidemiology KW - Risk Factors KW - Adult KW - Incidence KW - Middle Aged KW - Adolescent KW - Substance-Related Disorders -- epidemiology KW - Disruptive, Impulse Control, and Conduct Disorders -- epidemiology KW - Disruptive, Impulse Control, and Conduct Disorders -- diagnosis KW - Gambling -- psychology KW - Veterans -- statistics & numerical data KW - Suicide, Attempted -- statistics & numerical data KW - Disruptive, Impulse Control, and Conduct Disorders -- psychology KW - Veterans -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71394298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Suicide+attempts+among+veterans+seeking+treatment+for+pathological+gambling.&rft.au=Kausch%2C+Otto&rft.aulast=Kausch&rft.aufirst=Otto&rft.date=2003-09-01&rft.volume=64&rft.issue=9&rft.spage=1031&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-17 N1 - Date created - 2003-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The pathophysiology, medical management and dental implications of fragile X, Rett, and Prader-Willi syndromes. AN - 71276109; 14560873 AB - Fragile X, Rett, and Prader-Willi syndromes are a group of inherited disorders that often present with varying degrees of mental retardation and challenging behaviors. Dentists caring for individuals with these disorders must be familiar with the manifestations of these diseases and their associated features so they can garner the maximum level of cooperation from the patient. They must also be familiar with the medications (anticonvulsants, antihypertensives, antidepressants, antipsychotics, and central nervous system stimulants) used to treat the associated behaviors, because many of these pharmaceuticals cause clinically evident orofacial and systemic reactions, and may precipitate adverse interactions with dental therapeutic agents. JF - Journal of the California Dental Association AU - Friedlander, Arthur H AU - Yagiela, John A AU - Paterno, Victoria I AU - Mahler, Michael E AD - VA Greater Los Angeles Healthcare System, and Hospital Dental Service, UCLA Medical Center, CA 90073, USA. arthur.friedlander@med.va.gov Y1 - 2003/09// PY - 2003 DA - September 2003 SP - 693 EP - 702 VL - 31 IS - 9 SN - 1043-2256, 1043-2256 KW - Anticonvulsants KW - 0 KW - Antidepressive Agents KW - Antihypertensive Agents KW - Antipsychotic Agents KW - Central Nervous System Stimulants KW - Dentistry KW - Intellectual Disability -- etiology KW - Dental Caries -- etiology KW - Drug Interactions KW - Intellectual Disability -- drug therapy KW - Humans KW - Antihypertensive Agents -- adverse effects KW - Anticonvulsants -- adverse effects KW - Mouth Diseases -- chemically induced KW - Central Nervous System Stimulants -- adverse effects KW - Antidepressive Agents -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Rett Syndrome -- drug therapy KW - Prader-Willi Syndrome -- physiopathology KW - Prader-Willi Syndrome -- complications KW - Rett Syndrome -- physiopathology KW - Fragile X Syndrome -- physiopathology KW - Rett Syndrome -- complications KW - Prader-Willi Syndrome -- drug therapy KW - Fragile X Syndrome -- drug therapy KW - Fragile X Syndrome -- complications KW - Dental Care for Chronically Ill UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71276109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+California+Dental+Association&rft.atitle=The+pathophysiology%2C+medical+management+and+dental+implications+of+fragile+X%2C+Rett%2C+and+Prader-Willi+syndromes.&rft.au=Friedlander%2C+Arthur+H%3BYagiela%2C+John+A%3BPaterno%2C+Victoria+I%3BMahler%2C+Michael+E&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2003-09-01&rft.volume=31&rft.issue=9&rft.spage=693&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+California+Dental+Association&rft.issn=10432256&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-11-25 N1 - Date created - 2003-10-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Primary care physician attitudes concerning follow-up of abnormal test results and ambulatory decision support systems AN - 18939347; 5727913 AB - Objectives: Failures to follow-up abnormal test results are common in ambulatory care. Information systems could assist providers with abnormal test result tracking, yet little is known about primary care providers attitudes toward outpatient decision support systems. Methods: A cross-sectional survey of 216 primary care physicians (PCPs) that utilize a single electronic medical record (EMR) without computer-based clinical decision support. Results: The overall response rate was 65% (140/216). Less than one-third of the respondents were satisfied with their current system to manage abnormal laboratory, radiographs, Pap smear, or mammograms results. Only 15% of providers were satisfied with their system to notify patients of abnormal results. Over 90% of respondents felt automated systems to track abnormal test results would be useful. Seventy-nine percent of our respondents believed that they could comply better with guidelines through electronic clinical reminders. Conclusions: Most PCPs were not satisfied with their methods for tracking abnormal results. Respondents believed that clinical decision support systems (CDSS) would be useful and could improve their ability to track abnormal results. JF - International Journal of Medical Informatics AU - Murff, HJ AU - Gandhi, T K AU - Karson, A K AU - Mort, E A AU - Poon, E G AU - Wang, S J AU - Fairchild, D G AU - Bates, D W AD - Division of General Internal Medicine, Vanderbilt University Medical Center and Department of Veterans Affairs, TVH, GRECC Unit, 1310 24th Avenue South, Nashville, TN 37212-2637, USA, harvey.murff@med.va.gov Y1 - 2003/09// PY - 2003 DA - Sep 2003 SP - 137 EP - 149 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo@elsevier.com], [URL:http://www.elsevier.nl] VL - 71 IS - 2-3 SN - 1386-5056, 1386-5056 KW - decision support systems KW - electronic medical records KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Surveys KW - Bioinformatics KW - Computer applications KW - W4 140:Bioinformatics & Computers in Health & Medicine KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18939347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Medical+Informatics&rft.atitle=Primary+care+physician+attitudes+concerning+follow-up+of+abnormal+test+results+and+ambulatory+decision+support+systems&rft.au=Murff%2C+HJ%3BGandhi%2C+T+K%3BKarson%2C+A+K%3BMort%2C+E+A%3BPoon%2C+E+G%3BWang%2C+S+J%3BFairchild%2C+D+G%3BBates%2C+D+W&rft.aulast=Murff&rft.aufirst=HJ&rft.date=2003-09-01&rft.volume=71&rft.issue=2-3&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Medical+Informatics&rft.issn=13865056&rft_id=info:doi/10.1016%2FS1386-5056%2803%2900133-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bioinformatics; Surveys; Computer applications DO - http://dx.doi.org/10.1016/S1386-5056(03)00133-3 ER - TY - JOUR T1 - Changes in the NCCLS Breakpoints and Laboratory Reporting Strategies for Ceftriaxone/Cefotaxime and Streptococcus pneumoniae AN - 18880624; 5737905 AB - The NCCLS Committee on antimicrobial susceptibility testing published new minimum inhibitory concentration (MIC) breakpoints for ceftriaxone/cefotaxime for isolates of Streptococcus pneumoniae. The original, more stringent breakpoints are used for isolates from the meninges, while the one-doubling concentration-higher breakpoints are for isolates from patients without meningitis. These changes were based on the pharmacokinetic/pharmacodynamic (PK/PD) properties of ceftriaxone and cefotaxime and on outcome studies. Implementation of these breakpoints required educational intervention with physicians, pharmacists, medical technologists, and computer specialists. Within the past year, these new breakpoints have been implemented in many hospital systems. JF - Clinical Microbiology Newsletter AU - Brecher, S M AU - Ginocchio, C C AD - VA Medical Center, 1400 V.F.W. Pkwy., West Roxbury, MA 02132, USA, Brecher.stephen@boston.va.gov Y1 - 2003/09// PY - 2003 DA - Sep 2003 SP - 129 EP - 135 VL - 25 IS - 17 SN - 0196-4399, 0196-4399 KW - cefotaxime KW - ceftriaxone KW - minimum inhibitory concentration KW - pharmacodynamics KW - pharmacokinetics KW - Microbiology Abstracts B: Bacteriology KW - J 02793:Antibiotics: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18880624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+Newsletter&rft.atitle=Changes+in+the+NCCLS+Breakpoints+and+Laboratory+Reporting+Strategies+for+Ceftriaxone%2FCefotaxime+and+Streptococcus+pneumoniae&rft.au=Brecher%2C+S+M%3BGinocchio%2C+C+C&rft.aulast=Brecher&rft.aufirst=S&rft.date=2003-09-01&rft.volume=25&rft.issue=17&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+Newsletter&rft.issn=01964399&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Efficacy of Linezolid Alone or in Combination with Vancomycin for Treatment of Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus AN - 18869332; 5695486 AB - The levels of effectiveness of linezolid, vancomycin, and the combination of linezolid and vancomycin were compared in the rabbit model of endocarditis caused by a clinical methicillin-resistant Staphylococcus aureus (MRSA) isolate. Vancomycin alone was more effective than either linezolid alone or the combination of linezolid and vancomycin for the treatment of endocarditis due to MRSA. JF - Antimicrobial Agents & Chemotherapy AU - Chiang, F-Y AU - Climo, M AD - Hunter Holmes McGuire Veteran Affairs Medical Center, 1201 Broad Rock Blvd., Section 111-C, Richmond, VA 23249, Michael.Climo@med.va.gov Y1 - 2003/09// PY - 2003 DA - Sep 2003 SP - 3002 EP - 3004 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 47 IS - 9 SN - 0066-4804, 0066-4804 KW - linezolid KW - rabbits KW - vancomycin KW - Microbiology Abstracts B: Bacteriology KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18869332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Efficacy+of+Linezolid+Alone+or+in+Combination+with+Vancomycin+for+Treatment+of+Experimental+Endocarditis+Due+to+Methicillin-Resistant+Staphylococcus+aureus&rft.au=Chiang%2C+F-Y%3BClimo%2C+M&rft.aulast=Chiang&rft.aufirst=F-Y&rft.date=2003-09-01&rft.volume=47&rft.issue=9&rft.spage=3002&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.47.9.3002-3004.2003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1128/AAC.47.9.3002-3004.2003 ER - TY - JOUR T1 - Laser Eye Injuries in Military Occupations AN - 18831264; 5725340 AB - Introduction: Lasers (light amplification by stimulated emission of radiation) play an important role in our world and their use is increasing. They are powerful tools for good, but can also cause tragedy, especially in an aviation environment. Information about injuries associated with lasers is limited. This study highlights several laser eye injuries in the U.S. military and discusses issues pertaining to them. Methods: We gathered data from the U.S. Army Safety Center, the U.S. Army Center for Health Promotion and Preventive Medicine, and the Walter Reed Army Institute of Research. This paper describes ten representative cases of laser eye injury that occurred in the U.S. military between 1984 and 2000. Results: Patients suffered retinal damage, though no corneal injury occurred. Most were caused by accidental exposure to a Q-switched, Neodynium:YAG (Nd:YAG) laser at 1064 nm wavelength. The incidents occurred both on and off duty, indoors and outdoors, and from close and long ranges. None of the victims were wearing eye protection. Inadequate training and poor equipment design were major factors in at least six of the nine unintentional cases. The tenth occurred during military operations in the Persian Gulf. All of the victims needed several months medical care and follow up. Two received medical discharges as a result of their injuries. Discussion: As illustrated by these cases, human and societal costs from unintentional laser eye injuries can be reduced by improving operator training, safety procedure compliance, and equipment design. In addition, intentional laser eye injuries are a growing concern and further research is needed to design appropriate protection, treatment and countermeasures. JF - Aviation, Space and Environmental Medicine AU - Harris, MD AU - Lincoln, A E AU - Amoroso, P J AU - Stuck, B AU - Sliney, D AD - Research Health Scientist, War-Related Illness and Injury Study Center, VA Medical Center, MS 11, 50 Irving Street, NW, Washington, DC 20422, USA, andrew.lincoln@med.va.gov Y1 - 2003/09// PY - 2003 DA - Sep 2003 SP - 947 EP - 952 VL - 74 IS - 9 SN - 0095-6562, 0095-6562 KW - Health & Safety Science Abstracts KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18831264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aviation%2C+Space+and+Environmental+Medicine&rft.atitle=Laser+Eye+Injuries+in+Military+Occupations&rft.au=Harris%2C+MD%3BLincoln%2C+A+E%3BAmoroso%2C+P+J%3BStuck%2C+B%3BSliney%2C+D&rft.aulast=Harris&rft.aufirst=MD&rft.date=2003-09-01&rft.volume=74&rft.issue=9&rft.spage=947&rft.isbn=&rft.btitle=&rft.title=Aviation%2C+Space+and+Environmental+Medicine&rft.issn=00956562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Preventive and therapeutic approaches to viral agents of bioterrorism AN - 18834240; 5726047 AB - Certain viruses, such as those that cause smallpox and hemorrhagic fevers, have been identified as possible bioterrorism agents by the Centers for Disease Control and Prevention. They have been designated as potential threats because large quantities can be propagated in cell culture, they are transmissible as aerosols and, for the most part, there are only limited vaccine and pharmaceutical strategies for either prevention or treatment of established infection. An additional concern is the potential to genetically modify these agents to enhance virulence or promote resistance to vaccines or identified antivirals. Although the major impact of these agents is human illness, the release of zoonotic agents, such as the Nipah virus, would have consequences for both humans and animals because infected and noninfected animals might need to be sacrificed to control the spread of infection. Continued research is necessary to develop effective strategies to limit the impact of these biological threats. JF - Drug Discovery Today AU - Bronze AU - Greenfield, R A AD - Division of Infectious Diseases, University of Oklahoma Health, Sciences Center and the Oklahoma City, Veterans Administration Medical Center, Oklahoma City, USA Y1 - 2003/08/15/ PY - 2003 DA - 2003 Aug 15 SP - 740 EP - 745 PB - Elsevier Science Ltd VL - 8 IS - 16 SN - 1359-6446, 1359-6446 KW - antimicrobial resistance KW - bioterrorism KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Bioengineering Abstracts KW - W4 240:Bioterrorism & Biological Warfare KW - V 22124:Prophylaxis & control KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18834240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Discovery+Today&rft.atitle=Preventive+and+therapeutic+approaches+to+viral+agents+of+bioterrorism&rft.au=Bronze%3BGreenfield%2C+R+A&rft.aulast=Bronze&rft.aufirst=&rft.date=2003-08-15&rft.volume=8&rft.issue=16&rft.spage=740&rft.isbn=&rft.btitle=&rft.title=Drug+Discovery+Today&rft.issn=13596446&rft_id=info:doi/10.1016%2FS1359-6446%2803%2902778-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1016/S1359-6446(03)02778-8 ER - TY - JOUR T1 - Lessons learned in the use of tumor necrosis factor-alpha inhibitors in the treatment of rheumatoid arthritis. AN - 75757616; 14531954 AB - Tumor necrosis factor-alpha (TNFa) plays a central role in rheumatoid arthritis (RA) pathogenesis. There are currently three available anti-TNFa agents for the treatment of RA--adalimumab, etanercept, and infliximab. These targeted therapies have select advantages over traditional disease-modifying antirheumatic drugs (DMARDs), agents that have long been the mainstay of RA treatment. Compared with conventional DMARDs, TNFa inhibitors display a rapid onset of action and have shown a significant effect in retarding the radiographic joint destruction that often characterizes RA disease progression. Although anti-TNFa drugs represent an important advance in RA treatment, postmarketing reports of serious infections, as well as other adverse events, highlight the need for continued postmarketing vigilance with the use of these agents. This review evaluates the unique attributes of the available TNFa inhibitors, focusing specifically on recent reports providing important insight into the understanding of drug-related efficacy and toxicity. JF - Current rheumatology reports AU - Mikuls, Ted R AU - Weaver, Arthur L AD - Section of Rheumatology and Immunology, University of Nebraska Medical Center and the Omaha Veterans' Administration Medical Center, 983025 Nebraska Medical Center, Omaha, NE 68198, USA. tmikuls@unmc.edu Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 270 EP - 277 VL - 5 IS - 4 SN - 1523-3774, 1523-3774 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antirheumatic Agents KW - Immunoglobulin G KW - Receptors, Tumor Necrosis Factor KW - Tumor Necrosis Factor-alpha KW - Infliximab KW - B72HH48FLU KW - Adalimumab KW - FYS6T7F842 KW - Etanercept KW - OP401G7OJC KW - Index Medicus KW - Odds Ratio KW - Humans KW - Heart Failure -- chemically induced KW - Lymphoma -- chemically induced KW - Incidence KW - Demyelinating Diseases -- chemically induced KW - Arthritis, Rheumatoid -- drug therapy KW - Immunoglobulin G -- adverse effects KW - Immunoglobulin G -- pharmacology KW - Antirheumatic Agents -- adverse effects KW - Tumor Necrosis Factor-alpha -- antagonists & inhibitors KW - Antirheumatic Agents -- pharmacology KW - Antibodies, Monoclonal -- adverse effects KW - Antibodies, Monoclonal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75757616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+rheumatology+reports&rft.atitle=Lessons+learned+in+the+use+of+tumor+necrosis+factor-alpha+inhibitors+in+the+treatment+of+rheumatoid+arthritis.&rft.au=Mikuls%2C+Ted+R%3BWeaver%2C+Arthur+L&rft.aulast=Mikuls&rft.aufirst=Ted&rft.date=2003-08-01&rft.volume=5&rft.issue=4&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Current+rheumatology+reports&rft.issn=15233774&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-06 N1 - Date created - 2003-10-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Attempted suicide by a terminally ill patient. AN - 75715992; 14516508 JF - Journal of palliative medicine AU - Khanna, Poornima AU - Bulow, Kwi AD - Veterans Administration Medical Center, San Diego, CA 92121, USA. poonammd@yahoo.com Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 629 EP - 632 VL - 6 IS - 4 SN - 1096-6218, 1096-6218 KW - Index Medicus KW - Palliative Care -- psychology KW - Patient Care Team KW - Humans KW - Drug Overdose KW - Middle Aged KW - Male KW - Suicide, Attempted KW - Neoplasms -- complications KW - Depressive Disorder -- etiology KW - Depressive Disorder -- diagnosis KW - Depressive Disorder -- drug therapy KW - Physician's Role KW - Neoplasms -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75715992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+palliative+medicine&rft.atitle=Attempted+suicide+by+a+terminally+ill+patient.&rft.au=Khanna%2C+Poornima%3BBulow%2C+Kwi&rft.aulast=Khanna&rft.aufirst=Poornima&rft.date=2003-08-01&rft.volume=6&rft.issue=4&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=Journal+of+palliative+medicine&rft.issn=10966218&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-12-16 N1 - Date created - 2003-09-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessment of hepatic toxicity from treatment with 90Y-SMT 487 (OctreoTher(TM)) in patients with diffuse somatostatin receptor positive liver metastases. AN - 75698748; 14503953 AB - The purpose of this study was to determine whether there is evidence for hepatocellular radiation injury following treatment with (90)Y-SMT487 ((90)Y-DOTA-tyr3-octreotide, OctreoTher(TM)) in patients with extensive liver metastases from neuroendocrine tumors. Patients reported in this study participated in a Phase II trial of efficacy and safety of (90)Y-SMT487. The trial design called for three treatment cycles of 120 mCi each (4400 MBq) of (90)Y-SMT487. (111)In-pentetreotide SPECT images were used to determine the extent of liver metastases. Serum AST, ALT, and alkaline phosphatase levels were obtained at baseline and following each cycle of therapy. Least squares fit was applied to the serial liver enzyme measurements in patients with extensive liver metastases. Post-therapy liver enzyme measurements were also evaluated using WHO common toxicity criteria. Repeated-measures ANOVA and paired t-test were applied to the serial enzyme measures. There were 21 subjects. Fifteen of these had hepatic metastases with 12 demonstrating extensive (defined as 25% or more) liver involvement. In only 4 of these 15 did any of the three enzyme levels increase in WHO toxicity grade from baseline to final follow-up. We conclude that patients with diffuse SSTR positive hepatic metastases can be treated with a cumulative administered activity of 360 mCi (90)Y-SMT487 with only a small chance of developing mild acute or subacute hepatic radiation injury. JF - Cancer biotherapy & radiopharmaceuticals AU - Bushnell, David AU - Menda, Yusuf AU - Madsen, Mark AU - O'Dorisio, Thomas AU - Carlisle, Thomas AU - Zehr, Pamela AU - Ponto, Laura AU - Karwal, Mark AU - Parker, Stan AU - Ponto, James AU - Connolly, Mary AU - Bouterfa, Hakim AD - Iowa City Veterans Administration Hospital, Diagnostic Imaging and Radioisotope Therapy Service, and Department of Radiology, University of Iowa Roy J. and Lucille A. Carver School of Medicine, IA, USA. david.bushnell@uiowa.edu Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 581 EP - 588 VL - 18 IS - 4 SN - 1084-9785, 1084-9785 KW - Radiopharmaceuticals KW - 0 KW - Receptors, Somatostatin KW - Yttrium Radioisotopes KW - Somatostatin KW - 51110-01-1 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - pentetreotide KW - G083B71P98 KW - Octreotide KW - RWM8CCW8GP KW - Edotreotide KW - U194AS08HZ KW - Index Medicus KW - Radiopharmaceuticals -- therapeutic use KW - Aspartate Aminotransferases -- blood KW - Carcinoma, Neuroendocrine -- pathology KW - Analysis of Variance KW - Alanine Transaminase -- blood KW - Tomography, Emission-Computed, Single-Photon KW - Radiopharmaceuticals -- metabolism KW - Humans KW - Disease Progression KW - Alkaline Phosphatase -- blood KW - Radiopharmaceuticals -- adverse effects KW - Clinical Protocols KW - Yttrium Radioisotopes -- metabolism KW - Liver Neoplasms -- radiotherapy KW - Receptors, Somatostatin -- metabolism KW - Yttrium Radioisotopes -- therapeutic use KW - Liver -- pathology KW - Liver Neoplasms -- metabolism KW - Octreotide -- analogs & derivatives KW - Octreotide -- therapeutic use KW - Somatostatin -- analogs & derivatives KW - Liver Neoplasms -- secondary KW - Octreotide -- metabolism KW - Liver -- diagnostic imaging KW - Octreotide -- adverse effects KW - Yttrium Radioisotopes -- adverse effects KW - Liver -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75698748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biotherapy+%26+radiopharmaceuticals&rft.atitle=Assessment+of+hepatic+toxicity+from+treatment+with+90Y-SMT+487+%28OctreoTher%28TM%29%29+in+patients+with+diffuse+somatostatin+receptor+positive+liver+metastases.&rft.au=Bushnell%2C+David%3BMenda%2C+Yusuf%3BMadsen%2C+Mark%3BO%27Dorisio%2C+Thomas%3BCarlisle%2C+Thomas%3BZehr%2C+Pamela%3BPonto%2C+Laura%3BKarwal%2C+Mark%3BParker%2C+Stan%3BPonto%2C+James%3BConnolly%2C+Mary%3BBouterfa%2C+Hakim&rft.aulast=Bushnell&rft.aufirst=David&rft.date=2003-08-01&rft.volume=18&rft.issue=4&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Cancer+biotherapy+%26+radiopharmaceuticals&rft.issn=10849785&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-28 N1 - Date created - 2003-09-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 3-Hydroxyanthranilate in Cryptococcus neoformans: a secreted reductant that does not enable wood rot. AN - 73653157; 12964724 AB - Cryptococcus neoformans secretes 3-hydroxyanthranilate (3HAA), but the utility is unknown. Exogenous 3HAA promoted growth of cultures starved for iron with transferrin, presumably by releasing Fe(III) reductively. Exogenous 3HAA protected C. neoformans from strong oxidants, suggesting a role in resistance to killing by immune cells. 3HAA represents an endogenous laccase substrate, in that crude laccase preparations convert 3HAA to cinnabarinic acid, whereas 3HAA concentrations are higher in Lac- mutants. We isolated hypersecreting mutants as highly fluorescent clones. Because C. neoformans has been isolated from rotting wood, we looked for a role in degradation of lignin. Using cyclic voltammetry, we found no electrochemical evidence that organic oxidation products of 3HAA are capable of oxidizing lignin. We found neither cellulose dehydrogenase nor lignin peroxidase enzymic activity, nor did C. neoformans grow on cellulose as carbon source. We found no evidence for production of Fenton reagent by cultures, even in the presence of transition metal ions or of those and 3HAA. The biological utility of 3HAA may be related to its functions as reducing agent and, conceivably, as laccase substrate. It does not appear to attack wood, nor does C. neoformans appear to have a mechanism to rot wood. JF - Medical mycology AU - Jacobson, E S AU - Milhausen, S M AU - Manthey, M K AD - Research Service, McGuire Veterans Affairs Medical Center, Richmond, VA 23249, USA. Eric.Jacobson2@Med.va.gov Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 309 EP - 320 VL - 41 IS - 4 SN - 1369-3786, 1369-3786 KW - Antioxidants KW - 0 KW - Reducing Agents KW - Transferrin KW - 3-Hydroxyanthranilic Acid KW - 1UQB1BT4OT KW - Lignin KW - 9005-53-2 KW - Iron KW - E1UOL152H7 KW - Oxidoreductases KW - EC 1.- KW - Carbohydrate Dehydrogenases KW - EC 1.1.- KW - cellobiose-quinone oxidoreductase KW - EC 1.1.99.18 KW - Laccase KW - EC 1.10.3.2 KW - Peroxidases KW - EC 1.11.1.- KW - lignin peroxidase KW - Index Medicus KW - Transferrin -- metabolism KW - Carbohydrate Dehydrogenases -- metabolism KW - Antioxidants -- metabolism KW - Oxidoreductases -- metabolism KW - Oxidative Stress KW - Biodegradation, Environmental KW - Lignin -- metabolism KW - Iron -- metabolism KW - Peroxidases -- metabolism KW - Reducing Agents -- metabolism KW - 3-Hydroxyanthranilic Acid -- metabolism KW - Wood KW - Cryptococcus neoformans -- genetics KW - Cryptococcus neoformans -- metabolism KW - Cryptococcus neoformans -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73653157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+mycology&rft.atitle=3-Hydroxyanthranilate+in+Cryptococcus+neoformans%3A+a+secreted+reductant+that+does+not+enable+wood+rot.&rft.au=Jacobson%2C+E+S%3BMilhausen%2C+S+M%3BManthey%2C+M+K&rft.aulast=Jacobson&rft.aufirst=E&rft.date=2003-08-01&rft.volume=41&rft.issue=4&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Medical+mycology&rft.issn=13693786&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-11-05 N1 - Date created - 2003-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Smoking cessation treatment among dually diagnosed individuals: preliminary evaluation of different pharmacotherapies. AN - 73623387; 12959797 AB - This descriptive, observational pilot study evaluated a smoking cessation intervention using open-label bupropion and nicotine replacement within an addiction treatment center for patients with high rates of comorbid psychiatric diagnoses. Participants were 115 veterans receiving substance abuse treatment at a Veterans Administration outpatient program who voluntarily sought smoking cessation treatment. Three fourths of participants had a psychiatric diagnosis in addition to substance dependence (i.e., dual diagnosis). The intervention consisted of a weekly smoking cessation therapy group and pharmacotherapy as determined by participant and clinician preference (none, nicotine replacement only, bupropion only, or combined nicotine and bupropion). A total of 47 participants (40.9%) completed four group smoking cessation sessions, and 17 (14.8%) completed eight sessions. Of these participants, 27 (23.5%) had breath carbon monoxide (CO) levels <9 ppm (indicating short-term abstinence) at session 4, and nine (7.8%) had CO levels <9 ppm at session 8. Participants who received nicotine replacement alone or with bupropion attended more sessions than did subjects who did not receive nicotine replacement. Participants receiving combined medications had greater reductions in CO levels at session 4 than did the other participants. There was no evidence of increased use of other substances during smoking cessation treatment. These findings indicate that many dually diagnosed individuals are willing to attempt smoking cessation with appropriate pharmacotherapy and achieve reductions in CO measures, but only minimal success was observed with respect to cessation. Additional research is needed to assess medication effects in randomized trials, to explore effects of more intensive treatments, and to assess possible harm reduction from smoking interventions within this population. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Saxon, Andrew J AU - Baer, John S AU - Davis, Tania M AU - Sloan, Kevin L AU - Malte, Carol A AU - Fitzgibbons, Kerry AU - Kivlahan, Daniel R AD - VA Puget Sound Health Care System, University of Washington, Seattle, WA 98108, USA. andrew.saxon@med.va.gov Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 589 EP - 596 VL - 5 IS - 4 SN - 1462-2203, 1462-2203 KW - Dopamine Uptake Inhibitors KW - 0 KW - Ganglionic Stimulants KW - Bupropion KW - 01ZG3TPX31 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Drug Therapy, Combination KW - Psychotherapy, Group KW - Humans KW - Adult KW - Treatment Outcome KW - Diagnosis, Dual (Psychiatry) KW - Middle Aged KW - Counseling KW - Male KW - Female KW - Nicotine -- therapeutic use KW - Tobacco Use Disorder -- drug therapy KW - Bupropion -- therapeutic use KW - Mental Disorders KW - Smoking Cessation -- methods KW - Ganglionic Stimulants -- therapeutic use KW - Tobacco Use Disorder -- psychology KW - Nicotine -- administration & dosage KW - Dopamine Uptake Inhibitors -- therapeutic use KW - Smoking -- psychology KW - Ganglionic Stimulants -- administration & dosage KW - Smoking -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73623387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Smoking+cessation+treatment+among+dually+diagnosed+individuals%3A+preliminary+evaluation+of+different+pharmacotherapies.&rft.au=Saxon%2C+Andrew+J%3BBaer%2C+John+S%3BDavis%2C+Tania+M%3BSloan%2C+Kevin+L%3BMalte%2C+Carol+A%3BFitzgibbons%2C+Kerry%3BKivlahan%2C+Daniel+R&rft.aulast=Saxon&rft.aufirst=Andrew&rft.date=2003-08-01&rft.volume=5&rft.issue=4&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-06 N1 - Date created - 2003-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A new progressive ratio schedule for support of morphine self-administration in opiate dependent rats. AN - 73525686; 12732925 AB - In preliminary studies, we observed that opiate dependent rats self-administered only a small number of morphine injections under a PR (progressive ratio) schedule developed to study psychostimulant self-administration. Therefore, a new schedule was developed to support morphine self-administration by incrementing response requirements in a relatively gradual manner. The present study compared morphine self-administration under a commonly used PR schedule to self-administration maintained by our modified PR schedule. After pretreatment with non-contingent morphine, rats acquired self-administration under fixed-ratio (FR) schedules of intravenous morphine delivery. Morphine-maintained behavior was evaluated under a standard PR schedule (termed "PR3-4", because the third response requirement was four lever presses), and our modified PR schedule (termed "PR9-4", because the ninth response requirement was four lever presses). The PR9-4 schedule was also evaluated for self-administration of morphine doses of 0.001-3.2 mg/kg per injection. The number of ratios completed for morphine self-administration on the PR9-4 schedule, but not the PR3-4 schedule, exceeded values obtained during extinction. Dose-related increases in completed ratios occurred for morphine self-administration on the PR9-4 schedule, with stable patterns emerging after three sessions. A relatively flat dose-response relationship was observed, which did not increase monotonically with morphine dose. Morphine self-administration on the PR9-4 schedule decreased mean inter-injection interval and prolonged the duration of responding during 6-h sessions. In the present study, a schedule that incremented response requirement gradually (PR9-4) supported reliable self-administration across a range of morphine doses. JF - Psychopharmacology AU - Grasing, Kenneth AU - Li, Ning AU - He, Shaunteng AU - Parrish, Christopher AU - Delich, John AU - Glowa, John AD - Research Service, Kansas City Veterans Affairs Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA. kenneth.grasing@med.va.gov Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 387 EP - 396 VL - 168 IS - 4 SN - 0033-3158, 0033-3158 KW - Naloxone KW - 36B82AMQ7N KW - Morphine KW - 76I7G6D29C KW - Index Medicus KW - Rats KW - Naloxone -- administration & dosage KW - Animals KW - Substance Withdrawal Syndrome KW - Self Administration -- adverse effects KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Rats, Wistar KW - Cues KW - Time Factors KW - Male KW - Conditioning, Operant -- drug effects KW - Opioid-Related Disorders -- physiopathology KW - Reinforcement Schedule KW - Morphine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73525686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=A+new+progressive+ratio+schedule+for+support+of+morphine+self-administration+in+opiate+dependent+rats.&rft.au=Grasing%2C+Kenneth%3BLi%2C+Ning%3BHe%2C+Shaunteng%3BParrish%2C+Christopher%3BDelich%2C+John%3BGlowa%2C+John&rft.aulast=Grasing&rft.aufirst=Kenneth&rft.date=2003-08-01&rft.volume=168&rft.issue=4&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-12-24 N1 - Date created - 2003-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Combined amiodarone and silymarin treatment, but not amiodarone alone, prevents sustained atrial flutter in dogs. AN - 73519904; 12890050 AB - Amiodarone/Silymarin Treatment for Sustained Atrial Flutter. Because amiodarone generates free radicals that may mediate amiodarone's toxicity, simultaneous therapy with an antioxidant might be beneficial if the antioxidant did not impair amiodarone's antiarrhythmic action. We tested whether simultaneous administration of a flavonoid antioxidant, silymarin, altered the electrophysiologic (EP) actions of amiodarone in 62 open chest dogs with electrically induced atrial flutter created by a Y-shaped right atrial incision. Fifteen dogs received oral amiodarone (600 mg/day); 15 dogs received amiodarone (600 mg/day) and silymarin (70 mg bid); and 8 dogs received silymarin (70 mg bid) alone. All dosing was for 8 weeks; 24 control dogs received no drugs prior to induction of atrial flutter. Atrial flutter was induced by rapid right atrial pacing, and EP measurements were made before (presurgical) and after (postsurgical) creation of a Y-shaped right atrial incision. There was no difference in the frequency of induction of atrial flutter lasting >30 minutes among amiodarone-treated (8/15 [53%]), silymarin-treated (4/6 [67%]), and control (15/21 [71%]) groups, whereas the frequency of induction in the amiodarone+silymarin dogs (2/15 [13%]) was significantly reduced (P = 0.008) compared with the other three groups. Both amiodarone and amiodarone+silymarin treatment prolonged the presurgical and postsurgical right atrial effective refractory period (P = 0.012) compared with control; however, there was no significant difference in either parameter between the amiodarone+silymarin-treated and amiodarone-treated groups. The increase in atrial flutter mean cycle length (postsurgical minus presurgical) was significantly (P = 0.005) less in the amiodarone+silymarin-treated and control dogs compared with the amiodarone-treated dogs (16 +/- 11 msec for amiodarone+silymarin; 24 +/- 8 msec for control; and 42 +/- 14 msec for amiodarone treatment). Amiodarone+silymarin treatment resulted in a longer postsurgical right atrial refractory period (155 +/- 13 msec) than atrial flutter mean cycle length (154 +/- 19 msec), consistent with reduction and/or elimination of the excitable gap. Silymarin alone did not exert significant EP or antiarrhythmic action. Amiodarone exerted no preventative antiarrhythmic action in this atrial flutter model, probably because it could not reduce the excitable gap of atrial flutter. However, an antioxidant, silymarin, without a direct antiarrhythmic action, when administered together with amiodarone, potentiated amiodarone's antiarrhythmic actions and prevented sustained atrial flutter by reduction and/or elimination of the excitable gap. JF - Journal of cardiovascular electrophysiology AU - Vereckei, András AU - Zipes, Douglas P AU - Besch, Henry AD - Department of Medicine, Indiana University, School of Medicine and the Roudebush Veterans Administration Medical Center, Indianapolis Indiana 46202, USA. Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 861 EP - 867 VL - 14 IS - 8 SN - 1045-3873, 1045-3873 KW - Silymarin KW - 0 KW - Amiodarone KW - N3RQ532IUT KW - Index Medicus KW - Drug Therapy, Combination KW - Animals KW - Treatment Outcome KW - Dogs KW - Chronic Disease KW - Male KW - Female KW - Electrocardiography -- methods KW - Atrial Flutter -- diagnosis KW - Amiodarone -- administration & dosage KW - Silymarin -- administration & dosage KW - Atrial Flutter -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73519904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cardiovascular+electrophysiology&rft.atitle=Combined+amiodarone+and+silymarin+treatment%2C+but+not+amiodarone+alone%2C+prevents+sustained+atrial+flutter+in+dogs.&rft.au=Vereckei%2C+Andr%C3%A1s%3BZipes%2C+Douglas+P%3BBesch%2C+Henry&rft.aulast=Vereckei&rft.aufirst=Andr%C3%A1s&rft.date=2003-08-01&rft.volume=14&rft.issue=8&rft.spage=861&rft.isbn=&rft.btitle=&rft.title=Journal+of+cardiovascular+electrophysiology&rft.issn=10453873&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-30 N1 - Date created - 2003-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pneumoconiosis in a vermiculite end-product user. AN - 73487432; 12874855 AB - Vermiculite is a silicate used as an insulating agent, soil additive, and carrier for chemicals and fertilizers. It is currently perceived to have no adverse effects to "end-product" users. An 82-year-old man presented with complaints of progressive dyspnea on exertion. A clinical evaluation included a chest radiograph, complete pulmonary function testing, CT scan of the thorax, and comprehensive occupational and environmental history. The patient had clinical and radiographic features of advanced pulmonary interstitial fibrosis. The presence of calcified pleural plaques, together with the other clinical and radiographic features, strongly supported a diagnosis of asbestosis. His only significant exposure was to vermiculite used in the workplace for several hours per day from 1970 to 1987. This case represents the first report of an end-product vermiculite-user with probable asbestosis, and together with recent similar findings in a vermiculite expansion plant worker, requires further epidemiologic investigations. Published 2003 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Howard, Thomas Peter AD - Brevard VA Clinic, Viera, Florida 32940, USA. Thomas.Howard@Med.VA.Gov Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 214 EP - 217 VL - 44 IS - 2 SN - 0271-3586, 0271-3586 KW - Aluminum Silicates KW - 0 KW - vermiculite KW - 1318-00-9 KW - Index Medicus KW - Humans KW - Tomography, X-Ray Computed KW - Aged KW - Male KW - Pulmonary Fibrosis -- etiology KW - Pulmonary Fibrosis -- diagnosis KW - Aluminum Silicates -- adverse effects KW - Pneumoconiosis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73487432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Pneumoconiosis+in+a+vermiculite+end-product+user.&rft.au=Howard%2C+Thomas+Peter&rft.aulast=Howard&rft.aufirst=Thomas&rft.date=2003-08-01&rft.volume=44&rft.issue=2&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-11-12 N1 - Date created - 2003-07-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A reassessment of radioactive material security in health care and biomedical research. AN - 73464380; 12865744 AB - The medical facilities of the U.S. Department of Veterans Affairs (VA) use radioactive material for health care and biomedical research. In the past, a single level of security for all radioactive material was generally deemed to be adequate. The events of 11 September 2001 prompted a reassessment of security. Based on site visits to VA facilities possessing a range of radioactive material typically used in health care and biomedical research, the VA National Health Physics Program has compiled recommendations for the security of radioactive material. A primary recommendation is to evaluate radioactive material from a risk perspective and use security measures commensurate with risk. The risk evaluation should consider activity, half-life, exposure rate constant, ALI, ease of removal/portability, and dispersibility. We concluded that current security measures are likely adequate for the risks associated with most nuclear medicine departments and biomedical research laboratories. However, for radioactive material of higher risk, particularly multicurie sources of long half-life, the radiation safety staff should consult with police/security experts to determine if additional security measures are warranted. This focus on risk should help optimize resource allocation. We also recommend that security evaluations consider both physical security and personnel security, training of staff with unescorted access to higher-risk radioactive material emphasize security issues, and disposal of higher-risk material not likely to be used. Finally, we note that the goals of security can be in conflict with hazard awareness and hazard communication. JF - Health physics AU - Leidholdt, Edwin M AU - William, Gary E AU - McGuire, Lynn E AD - VHA National Health Physics Program (115HP/NLR), U.S. Department of Veterans Affairs, 2200 Fort Roots Drive, North Little Rock, AR 72114, USA. edwin.leidholt@med.va.gov Y1 - 2003/08// PY - 2003 DA - August 2003 SP - S15 EP - S19 VL - 85 IS - 2 Suppl SN - 0017-9078, 0017-9078 KW - Radioactive Waste KW - 0 KW - Index Medicus KW - United States KW - Terrorism KW - Radioactive Hazard Release KW - United States Department of Veterans Affairs KW - Humans KW - Refuse Disposal -- standards KW - Risk Assessment KW - Radiation Protection KW - Research -- standards KW - Safety Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73464380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=A+reassessment+of+radioactive+material+security+in+health+care+and+biomedical+research.&rft.au=Leidholdt%2C+Edwin+M%3BWilliam%2C+Gary+E%3BMcGuire%2C+Lynn+E&rft.aulast=Leidholdt&rft.aufirst=Edwin&rft.date=2003-08-01&rft.volume=85&rft.issue=2+Suppl&rft.spage=S15&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-06 N1 - Date created - 2003-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Autologous stem cell transplantation for Hodgkin's disease: busulfan, melphalan and thiotepa compared to a radiation-based regimen. AN - 73464107; 12858199 AB - We evaluated prognostic factors and treatment outcome of patients with relapsed/refractory Hodgkin's disease (HD) receiving autologous stem cell transplantation (ASCT). In total, 92 patients received total body irradiation, cyclophosphamide and etoposide (TBI/CY/E) (n=42) or busulfan, melphalan and thiotepa (Bu/Mel/T) (n=50) supported with ASCT. A total of 33 (66%) patients receiving the Bu/Mel/T regimen had a prior history of dose-limiting irradiation. Mucositis, hepatic and pulmonary toxicities were the main causes of morbidity and mortality, irrespective of the conditioning regimen. The transplant-related mortality was 15%. With a median follow-up of 6 years (range 2.5-11), the cumulative probabilities of survival, event-free survival (EFS) and relapse at 6 years were 55, 51 and 32%. The 6-year Kaplan-Meier (KM) probabilities of EFS for patients with less advanced disease (patients in first chemotherapy-responsive relapse or second remission (n=42)) and more advanced disease (all other patients (n=50)) were 60 and 44%. No differences in toxicities and efficacy between the conditioning regimens were found. ASCT is an effective treatment for patients with refractory/relapsed HD. Female patients and patients with less advanced disease at transplant had a better outcome. Patients with prior irradiation benefited from the Bu/Mel/T regimen. JF - Bone marrow transplantation AU - Gutierrez-Delgado, F AU - Holmberg, L AU - Hooper, H AU - Petersdorf, S AU - Press, O AU - Maziarz, R AU - Maloney, D AU - Chauncey, T AU - Appelbaum, F AU - Bensinger, W AD - Fred Hutchinson Cancer Research, Veterans Administration Hospital, University of Washington, Seattle, WA, USA. Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 279 EP - 285 VL - 32 IS - 3 SN - 0268-3369, 0268-3369 KW - Thiotepa KW - 905Z5W3GKH KW - Busulfan KW - G1LN9045DK KW - Melphalan KW - Q41OR9510P KW - Index Medicus KW - Humans KW - Prognosis KW - Retrospective Studies KW - Transplantation, Autologous KW - Busulfan -- administration & dosage KW - Melphalan -- administration & dosage KW - Risk Factors KW - Adult KW - Treatment Outcome KW - Thiotepa -- administration & dosage KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Salvage Therapy -- methods KW - Survival Analysis KW - Hematopoietic Stem Cell Transplantation -- mortality KW - Whole-Body Irradiation KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Hodgkin Disease -- therapy KW - Hodgkin Disease -- complications KW - Antineoplastic Combined Chemotherapy Protocols -- toxicity KW - Hodgkin Disease -- mortality KW - Hematopoietic Stem Cell Transplantation -- methods KW - Hematopoietic Stem Cell Transplantation -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73464107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bone+marrow+transplantation&rft.atitle=Autologous+stem+cell+transplantation+for+Hodgkin%27s+disease%3A+busulfan%2C+melphalan+and+thiotepa+compared+to+a+radiation-based+regimen.&rft.au=Gutierrez-Delgado%2C+F%3BHolmberg%2C+L%3BHooper%2C+H%3BPetersdorf%2C+S%3BPress%2C+O%3BMaziarz%2C+R%3BMaloney%2C+D%3BChauncey%2C+T%3BAppelbaum%2C+F%3BBensinger%2C+W&rft.aulast=Gutierrez-Delgado&rft.aufirst=F&rft.date=2003-08-01&rft.volume=32&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Bone+marrow+transplantation&rft.issn=02683369&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-24 N1 - Date created - 2003-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Resident Outcomes of Medicaid-Funded Community Residential Care AN - 61342894; 200401073 AB - Purpose: WA initiatives to increase the availability & quality of community residential care presented an opportunity to describe clients entering adult family homes, adult residential care, & assisted living, & to identify outcomes of care. Design & Methods: We enrolled 349 residents, 243 informal caregivers, & 299 providers in 219 settings. We conducted interviews at enrollment & 12 months later, & we collected data from state databases. Results: The average resident was a 78-year-old woman reporting dependence in two of six activities of daily living. Residents in adult family homes demonstrated significantly more disability. Seventy-eight percent of residents survived at the 12-month follow-up. In analyses that controlled for differences at enrollment, residents in the three types of settings were very similar in health outcomes at follow-up. Implications: State policies should reflect the wide range of needs of residents seeking care in these settings. Choices among type of setting can be based on the match of needs to individual preferences. 5 Tables, 1 Figure, 30 References. Adapted from the source document. JF - The Gerontologist AU - Hedrick, Susan C AU - Sales, Anne E B AU - Sullivan, Jean H AU - Gray, Shelly L AU - Tornatore, Jane AU - Curtis, Michael AU - Zhou, Xiao-Hua Andrew AD - VA Puget Sound Health Care System, Seattle, WA susan.hedrick@med.va.gov Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 473 EP - 482 VL - 43 IS - 4 SN - 0016-9013, 0016-9013 KW - Adult Care Services KW - Washington (State) KW - Long Term Care KW - Activities of Daily Living KW - Health KW - article KW - 6111: social work theory/research KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61342894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=Resident+Outcomes+of+Medicaid-Funded+Community+Residential+Care&rft.au=Hedrick%2C+Susan+C%3BSales%2C+Anne+E+B%3BSullivan%2C+Jean+H%3BGray%2C+Shelly+L%3BTornatore%2C+Jane%3BCurtis%2C+Michael%3BZhou%2C+Xiao-Hua+Andrew&rft.aulast=Hedrick&rft.aufirst=Susan&rft.date=2003-08-01&rft.volume=43&rft.issue=4&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-10-30 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Washington (State); Adult Care Services; Activities of Daily Living; Long Term Care; Health ER - TY - JOUR T1 - Masculinity and Emotionality: An Investigation of Men's Primary and Secondary Emotional Responding AN - 60472042; 200321537 AB - In this study, we investigated the role of masculinity in men's affect intensity & men's fear of emotions. Men's masculine ideology & self-reported masculine gender role stress were assessed as cognitive & experiential factors of adherence to traditional masculine gender norms. Masculine ideology was negatively related to men's global affect intensity. However, on a 3-factor model of affect intensity, only negative reactivity was significantly related to masculine ideology. Both masculine ideology & masculine gender role stress were positively related to men's fear of emotions. Results are discussed in the context of theories of gender differences in emotion. 5 Tables, 52 References. Adapted from the source document. JF - Sex Roles: A Journal of Research AU - Jakupcak, Matthew AU - Salters, Kristalyn AU - Gratz, Kim L AU - Roemer, Lizabeth AD - Veterans Affairs Puget Sound Health Care System, Seattle, WA matthew.jakupcak@med.va.gov Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 111 EP - 120 VL - 49 IS - 3-4 SN - 0360-0025, 0360-0025 KW - Masculinity KW - Emotions KW - Fear KW - Males KW - Sex Differences KW - College Students KW - Sex Stereotypes KW - article KW - 2983: feminist/gender studies; sociology of gender & gender relations KW - 0312: social psychology; personality & social roles (individual traits, social identity, adjustment, conformism, & deviance) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60472042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sex+Roles%3A+A+Journal+of+Research&rft.atitle=Masculinity+and+Emotionality%3A+An+Investigation+of+Men%27s+Primary+and+Secondary+Emotional+Responding&rft.au=Jakupcak%2C+Matthew%3BSalters%2C+Kristalyn%3BGratz%2C+Kim+L%3BRoemer%2C+Lizabeth&rft.aulast=Jakupcak&rft.aufirst=Matthew&rft.date=2003-08-01&rft.volume=49&rft.issue=3-4&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Sex+Roles%3A+A+Journal+of+Research&rft.issn=03600025&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SROLDH N1 - SubjectsTermNotLitGenreText - Masculinity; Males; Emotions; Sex Stereotypes; Sex Differences; Fear; College Students ER - TY - JOUR T1 - Discriminative Validity of Selected Measures for Differentiating Normal from Aphasic Performance AN - 57190892; 200611557 AB - Normal elderly & mildly aphasic individuals may exhibit similar impairments in comprehension & expression. The discriminative validity between normal & aphasic performance on most standardized measures of aphasia has not been reported. The authors compared the performance of 18 aphasic & 18 normal adults to determine the discriminative validity of 2 general language measures -- the Porch Index of Communicative Ability (B. E. Porch, 1967) & the Western Aphasia Battery (A. Kertesz, 1982) -- & 2 functional communication measures -- the Communication Activities of Daily Living-Second Edition (A. L. Holland, C. Frattali, & D. Fromm, 1999) & the American Speech-Language-Hearing Association's Functional Assessment of Communication Skills for Adults (C. Frattali, C. K. Thompson, A. L. Holland, C. B. Wohl, & M. K. Ferketic, 1995). All between-groups comparisons of summary scores for each measure showed significant mean differences. Expressive language ability & efficiency of performance best differentiated between the aphasic & normal groups. However, group performance ranges overlapped by at least 10% on each measure. To enhance the differential diagnosis of aphasia, supplementing formal test results with additional subjective & objective evidence is recommended. Adapted from the source document. JF - American Journal of Speech-Language Pathology AU - Ross, Katherine B AU - Wertz, Robert T AD - Carl T. Hayden VA Medical Center, Phoenix, AZ katherine.ross3@med.va.gov Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 312 EP - 319 PB - American Speech-Language-Hearing Association, Rockville MD VL - 12 IS - 3 SN - 1058-0360, 1058-0360 KW - aphasia, diagnosis, language impairment, activity limitation, validity KW - Elderly people KW - Diagnostic testing KW - Aphasia KW - Validity KW - Language disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57190892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Speech-Language+Pathology&rft.atitle=Discriminative+Validity+of+Selected+Measures+for+Differentiating+Normal+from+Aphasic+Performance&rft.au=Ross%2C+Katherine+B%3BWertz%2C+Robert+T&rft.aulast=Ross&rft.aufirst=Katherine&rft.date=2003-08-01&rft.volume=12&rft.issue=3&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Speech-Language+Pathology&rft.issn=10580360&rft_id=info:doi/10.1044%2F1058-0360 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-07-28 N1 - Last updated - 2016-09-27 N1 - CODEN - AJSPFZ N1 - SubjectsTermNotLitGenreText - Aphasia; Elderly people; Language disorders; Diagnostic testing; Validity DO - http://dx.doi.org/10.1044/1058-0360 ER - TY - JOUR T1 - Activity of clarithromycin alone and in combination in a murine model of Mycobacterium kansasii infection AN - 19160218; 5744950 AB - Activities of clarithromycin alone and in combination with rifampicin, gatifloxacin or linezolid were evaluated against Mycobacterium kansasii in a murine infection model. Clarithromycin was the most active single agent. Rifampicin and gatifloxacin had similar activities, but were less active than clarithromycin. Clarithromycin in combination with rifampicin was the most active combination therapy. JF - Journal of Antimicrobial Chemotherapy AU - Cynamon, M H AU - Elliott, SA AU - DeStefano AU - Yeo, AET AD - Department of Medicine, Veterans Affairs Medical Center, 800 Irving Avenue, Syracuse, NY 13210, USA, Michael.Cynamon@med.VA.gov Y1 - 2003/08// PY - 2003 DA - Aug 2003 SP - 306 EP - 307 VL - 52 IS - 2 SN - 0305-7453, 0305-7453 KW - mice KW - Microbiology Abstracts B: Bacteriology KW - Rifampin KW - Clarithromycin KW - Animal models KW - Mycobacterium kansasii KW - Gatifloxacin KW - J 02855:Human Bacteriology: Others KW - J 02786:Macrolide antibiotics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19160218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Activity+of+clarithromycin+alone+and+in+combination+in+a+murine+model+of+Mycobacterium+kansasii+infection&rft.au=Cynamon%2C+M+H%3BElliott%2C+SA%3BDeStefano%3BYeo%2C+AET&rft.aulast=Cynamon&rft.aufirst=M&rft.date=2003-08-01&rft.volume=52&rft.issue=2&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkg323 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium kansasii; Animal models; Clarithromycin; Rifampin; Gatifloxacin DO - http://dx.doi.org/10.1093/jac/dkg323 ER - TY - JOUR T1 - Gatifloxacin and Ethionamide as the Foundation for Therapy of Tuberculosis AN - 18860672; 5675661 AB - The use of gatifloxacin (GAT) in combination with ethionamide (ETA) with or without pyrazinamide (PZA) for a 12-week treatment period followed by an 8-week observation period was evaluated in a model of tuberculosis in mice. Mice treated with GAT at 300 mg/kg of body weight in combination with ETA (25 mg/kg) for 5 days per week had sterile lungs, whereas mice treated with GAT (100 mg/kg) and ETA (25 mg/kg) had about 10 CFU/lung; however, there was regrowth of the organisms in both groups at the end of the observation period. When PZA (450 mg/kg 5 days per week) was added to the high-dose GAT-ETA regimen, no viable mycobacteria were present after the 8-week observation period. GAT in combination with ETA and PZA has great promise for the treatment of tuberculosis. JF - Antimicrobial Agents & Chemotherapy AU - Cynamon, M H AU - Sklaney, M AD - VAMC, 800 Irving Ave., Syracuse, NY 13210, Michael.Cynamon@Med.VA.Gov Y1 - 2003/08// PY - 2003 DA - Aug 2003 SP - 2442 EP - 2444 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 47 IS - 8 SN - 0066-4804, 0066-4804 KW - ethionamide KW - mice KW - pyrazinamide KW - Microbiology Abstracts B: Bacteriology KW - J 02806:Quinones, quinolones and quinolines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18860672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Gatifloxacin+and+Ethionamide+as+the+Foundation+for+Therapy+of+Tuberculosis&rft.au=Cynamon%2C+M+H%3BSklaney%2C+M&rft.aulast=Cynamon&rft.aufirst=M&rft.date=2003-08-01&rft.volume=47&rft.issue=8&rft.spage=2442&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.47.8.2442-2444.2003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1128/AAC.47.8.2442-2444.2003 ER - TY - JOUR T1 - How Harmful Is Hazardous Alcohol Use and Abuse in HIV Infection: Do Health Care Providers Know Who Is at Risk? AN - 18815930; 5692720 AB - We conducted a prospective cohort study to describe the association between alcohol use, HIV disease progression, and drug toxicity and to determine health care provider awareness of excessive alcohol use by recruiting 881 HIV-infected veterans (median age, 49 years; 99% male; 54% African American) from 3 VA HIV clinics. Twenty percent of patients were hazardous drinkers by the Alcohol Use Disorders Identification Test, 33% were binge drinkers, 32% had a chart ICD-9 alcohol diagnosis, and 12.5% and 66.7%, respectively, were described by their health care providers as currently and ever drinking "too much." Hazardous/binge drinkers more often had detectable viral loads (P 200/mL. We conclude that in HIV-positive veterans, hazardous drinking and alcohol diagnoses were common and associated with HIV disease progression and/or hepatic comorbidity and anemia. Health care providers more often missed alcohol problems in patients with less severe HIV infection and those without evidence of liver disease. Health care providers should routinely screen and counsel patients regarding alcohol problems as part of standard of care to minimize disease progression and bone marrow and hepatic toxicity. JF - JAIDS Journal of Acquired Immune Deficiency Syndromes AU - Conigliaro, J AU - Gordon, A J AU - McGinnis, KA AU - Rabeneck, L AU - Justice, A C AD - VA Pittsburgh Healthcare System, University Drive C, 130-VACS, Pittsburgh, PA 15240, USA, amy.justice@med.va.gov Y1 - 2003/08/01/ PY - 2003 DA - 2003 Aug 01 SP - 521 EP - 525 VL - 33 IS - 4 SN - 1525-4135, 1525-4135 KW - HIV KW - disease transmission KW - substance abuse KW - Risk Abstracts; Virology & AIDS Abstracts KW - V 22006:AIDS: Other aspects KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18815930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAIDS+Journal+of+Acquired+Immune+Deficiency+Syndromes&rft.atitle=How+Harmful+Is+Hazardous+Alcohol+Use+and+Abuse+in+HIV+Infection%3A+Do+Health+Care+Providers+Know+Who+Is+at+Risk%3F&rft.au=Conigliaro%2C+J%3BGordon%2C+A+J%3BMcGinnis%2C+KA%3BRabeneck%2C+L%3BJustice%2C+A+C&rft.aulast=Conigliaro&rft.aufirst=J&rft.date=2003-08-01&rft.volume=33&rft.issue=4&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=JAIDS+Journal+of+Acquired+Immune+Deficiency+Syndromes&rft.issn=15254135&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - The anxiogenic beta-carboline FG-7142 inhibits locomotor exploration similarly in postweanling and adult rats. AN - 73395144; 12850534 AB - The beta-carboline FG-7142 exerts many stress-like effects in the adult rat, including the inhibition of locomotor exploration. However, comparable effects in immature animals have not been reported. Stress-like effects of FG-7142 are mediated via its inverse agonist actions on gamma-aminobutyric acid (GABA) receptors. GABA systems change considerably with development and GABA agonists such as diazepam have opposite behavioral actions in immature and adult rats. Accordingly, we compared FG-7142 effects on locomotor exploration in postweanling and adult rats. Postweanling male rats (24 days) and adult rats (90 days) received a single injection of vehicle or FG-7142 (15 mg/kg i.p.) and 15 min later were placed in photocell monitors for 1 h. Although postweanling animals traveled a smaller distance overall than adults, FG-7142 inhibited locomotor exploration to a similar degree in both groups. We conclude that FG-7142 exerts stress-like effects in postweanling rats and may be considered for use as a model of childhood stress. JF - Neuroscience letters AU - Jaskiw, George E AU - Lipska, Barbara K AU - Weinberger, Daniel R AD - Louis Stokes Cleveland Veterans Administration Medical Center, Cleveland, OH 44141, USA. gxj75@po.cwru.edu Y1 - 2003/07/31/ PY - 2003 DA - 2003 Jul 31 SP - 5 EP - 8 VL - 346 IS - 1-2 SN - 0304-3940, 0304-3940 KW - Carbolines KW - 0 KW - FG 7142 KW - 60PO70N1BP KW - Index Medicus KW - Rats KW - Animals KW - Age Factors KW - Stress, Psychological -- chemically induced KW - Weaning KW - Stress, Psychological -- psychology KW - Anxiety -- psychology KW - Anxiety -- chemically induced KW - Exploratory Behavior -- drug effects KW - Carbolines -- toxicity KW - Exploratory Behavior -- physiology KW - Motor Activity -- physiology KW - Motor Activity -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73395144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=The+anxiogenic+beta-carboline+FG-7142+inhibits+locomotor+exploration+similarly+in+postweanling+and+adult+rats.&rft.au=Jaskiw%2C+George+E%3BLipska%2C+Barbara+K%3BWeinberger%2C+Daniel+R&rft.aulast=Jaskiw&rft.aufirst=George&rft.date=2003-07-31&rft.volume=346&rft.issue=1-2&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-09-02 N1 - Date created - 2003-07-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of ABR stimuli for the early detection of ototoxicity: conventional clicks compared with high frequency clicks and single frequency tonebursts. AN - 85381034; pmid-12956307 AB - Effective objective testing methodology is needed for early detection of the effects of ototoxicity on hearing in patients. The requirements for such testing include responses that are: 1) reliable across test sessions; 2) sensitive to ototoxic change ( > 8 kHz), and 3) recordable in a time-efficient manner. Auditory brainstem responses (ABR) appear well suited to this task however, conventional clicks stimulate primarily mid-frequencies (1-4 kHz) and high frequency tonebursts require too much time. We hypothesized that delivery of a band of high frequencies (a high frequency "click"), would elicit reliable and useful ABRs. In the current study, flat and sloped HF (high frequency) clicks with a bandwidth of 8-14 kHz were used. The purpose was to compare brainstem responses elicited by tonebursts, two HF clicks and conventional clicks. The results show that the reliability of responses to the HF clicks were comparable to the tonebursts and further, both HF clicks produced responses slightly larger than tonebursts. JF - Journal of the American Academy of Audiology AU - Fausti, Stephen A AU - Flick, Christopher L AU - Bobal, Alison M AU - Ellingson, Roger M AU - Henry, James A AU - Mitchell, Curtin R AD - National Center for Rehabilitative Auditory Research, 3710 SW US Veterans Hospital Road (R&D-NCRAR), Portland, Oregon 97207, USA. fausti.stephen@portland.va.gov Y1 - 2003/07// PY - 2003 DA - Jul 2003 SP - 239 EP - 50; quiz 281-2 VL - 14 IS - 5 SN - 1050-0545, 1050-0545 KW - Index Medicus KW - National Library of Medicine KW - *Acoustic Stimulation: methods KW - Analysis of Variance KW - Early Diagnosis KW - *Evoked Potentials, Auditory, Brain Stem KW - *Hearing Disorders: chemically induced KW - *Hearing Disorders: diagnosis KW - Hearing Disorders: physiopathology KW - Hearing Loss, High-Frequency: chemically induced KW - Hearing Loss, High-Frequency: diagnosis KW - Humans KW - Reproducibility of Results UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85381034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Audiology&rft.atitle=Comparison+of+ABR+stimuli+for+the+early+detection+of+ototoxicity%3A+conventional+clicks+compared+with+high+frequency+clicks+and+single+frequency+tonebursts.&rft.au=Fausti%2C+Stephen+A%3BFlick%2C+Christopher+L%3BBobal%2C+Alison+M%3BEllingson%2C+Roger+M%3BHenry%2C+James+A%3BMitchell%2C+Curtin+R&rft.aulast=Fausti&rft.aufirst=Stephen&rft.date=2003-07-01&rft.volume=14&rft.issue=5&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Audiology&rft.issn=10500545&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: J Am Acad Audiol. 2003 Jul;14(5):230[12956305] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - EphA4 provides repulsive signals to developing cochlear ganglion neurites mediated through ephrin-B2 and -B3. AN - 85269583; pmid-12761826 AB - The ephrins and Eph receptors make up two large families of bi-directional signaling molecules that are known to play a role in the development of the nervous system. Recently, expression of EphA4 in the developing cochlea was shown, with strong expression in cells lining the osseous spiral lamina (OSL) through which afferent dendrites must pass to reach the organ of Corti (OC). It was also demonstrated that ephrin-B2 and -B3, both of which are known to interact with EphA4, are expressed by spiral ganglion (SG) neurons. To investigate the functional role of EphA4 in the development of inner ear neurons, neonatal rat SG explants were cultured for 72 hours on uniformly coated surfaces or near stripes of EphA4/IgG-Fc-chimera. Control explants were cultured on or near IgG-Fc and EphA1/IgG-Fc-chimera. To assess the roles of ephrin-B2 and -B3 in EphA4 signaling, SG explants were cultured with or without anti-ephrin-B2 and/or -B3 blocking antibodies. Growth patterns of SG neurites at the border of EphA4 receptor stripes showed repulsion, characterized by turning, stopping and/or reversal. In the case of IgG-Fc and EphA1, the neurites grew straight onto the stripes. Treatment with either anti-ephrin-B2 or -B3 blocking antibodies significantly reduced the repulsive effect of an EphA4 stripe. Moreover, when both antibodies were used together, neurites crossed onto EphA4 stripes with no evidence of repulsion. The results suggest that EphA4 provides repulsive signals to SG neurites in the developing cochlea, and that ephrin-B2 and -B3 together mediate this response. JF - The Journal of Comparative Neurology AU - Brors Dominik AU - Bodmer, Daniel AU - Pak Kwang AU - Aletsee Christoph AU - Schäfers Maria AU - Dazert Stefan AU - Ryan, Allen F AD - Department of Surgery, Division Otolaryngology and Neurosciences, University of California, San Diego School of Medicine and Veterans Administration Medical Center, La Jolla 92093, USA. PY - 2003 SP - 90 EP - 100 VL - 462 IS - 1 SN - 0021-9967, 0021-9967 KW - Receptor, EphA4 KW - Ephrin-B3 KW - Support, U.S. Gov't, P.H.S. KW - Ephrin-B2 KW - Animal KW - Cell Differentiation KW - Spiral Ganglion KW - Neurons, Afferent KW - Chimeric Proteins KW - Neurites KW - Growth Cones KW - Rats KW - Animals, Newborn KW - Antibodies KW - Rats, Sprague-Dawley KW - Organ Culture KW - Cell Communication KW - Support, Non-U.S. Gov't KW - Support, U.S. Gov't, Non-P.H.S. KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85269583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Comparative+Neurology&rft.atitle=EphA4+provides+repulsive+signals+to+developing+cochlear+ganglion+neurites+mediated+through+ephrin-B2+and+-B3.&rft.au=Brors+Dominik%3BBodmer%2C+Daniel%3BPak+Kwang%3BAletsee+Christoph%3BSch%C3%A4fers+Maria%3BDazert+Stefan%3BRyan%2C+Allen+F&rft.aulast=Brors+Dominik&rft.aufirst=&rft.date=2003-07-01&rft.volume=462&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Comparative+Neurology&rft.issn=00219967&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Quantitative electroencephalographic studies of cue-induced cocaine craving. AN - 75748558; 14521273 AB - Quantitative electroencephalographic (qEEG) profiles were studied in cocaine dependent patients in response to cocaine cue exposure. Using neurometric analytical methods, the spectral power of each primary bandwidth was computed and topographically mapped. Additional measures of cue-reactivity included cocaine craving, anxiety and related subjective ratings, and physiological measures of skin conductance, skin temperature, heart rate, and plasma cortisol and HVA levels. Twenty-four crack cocaine-dependent subjects were tested for their response to tactile, visual and audio cues related to crack cocaine or neutral items. All measures were analyzed for significant difference by comparing cocaine versus neutral cue conditions. An increase in cocaine craving, anxiety and related subjective ratings, elevated plasma cortisol levels, and a decrease in skin temperature, were induced by cocaine cue exposure. Distinct qEEG profiles were found during the paraphernalia handling and video viewing (eyes-open), and guided imagery (eyes-closed), phases of cocaine cue exposure. During paraphernalia handling and video viewing, there was an increase in beta activity accompanied by a drop in delta power in the frontal cortex, and an increase in beta mean frequency in the occipital cortex. In contrast, during guided imagery there was an increase in theta and delta power in the frontal cortex, and an increase in beta power in the occipital cortex. Correlation analyses revealed that cue-induced anxiety during paraphernalia handling and video viewing was associated with reduced high frequency and enhanced low frequency EEG activity. These findings demonstrated that EEG activation during cue-induced cocaine craving may be topographically mapped and subsequently analyzed for functional relevance. JF - Clinical EEG (electroencephalography) AU - Reid, Malcolm S AU - Prichep, Leslie S AU - Ciplet, Debra AU - O'Leary, Siobhan AU - Tom, MeeLee AU - Howard, Bryant AU - Rotrosen, John AU - John, E Roy AD - Department of Psychiatry, New York University School of Medicine, and V.A. New York Harbor Healthcare System, New York, NY 10010, USA. malcolm.reid@med.va.gov Y1 - 2003/07// PY - 2003 DA - July 2003 SP - 110 EP - 123 VL - 34 IS - 3 SN - 0009-9155, 0009-9155 KW - Index Medicus KW - Brain Mapping -- methods KW - Humans KW - Adult KW - Aged KW - Predictive Value of Tests KW - Middle Aged KW - Statistics as Topic KW - Adolescent KW - Male KW - Female KW - Photic Stimulation -- methods KW - Cocaine-Related Disorders -- diagnosis KW - Diagnosis, Computer-Assisted -- methods KW - Conditioning (Psychology) KW - Cocaine-Related Disorders -- psychology KW - Cues KW - Cocaine-Related Disorders -- physiopathology KW - Behavior, Addictive -- psychology KW - Behavior, Addictive -- complications KW - Behavior, Addictive -- physiopathology KW - Electroencephalography -- methods KW - Cocaine-Related Disorders -- complications KW - Behavior, Addictive -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75748558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+EEG+%28electroencephalography%29&rft.atitle=Quantitative+electroencephalographic+studies+of+cue-induced+cocaine+craving.&rft.au=Reid%2C+Malcolm+S%3BPrichep%2C+Leslie+S%3BCiplet%2C+Debra%3BO%27Leary%2C+Siobhan%3BTom%2C+MeeLee%3BHoward%2C+Bryant%3BRotrosen%2C+John%3BJohn%2C+E+Roy&rft.aulast=Reid&rft.aufirst=Malcolm&rft.date=2003-07-01&rft.volume=34&rft.issue=3&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Clinical+EEG+%28electroencephalography%29&rft.issn=00099155&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-05 N1 - Date created - 2003-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Celecoxib and rofecoxib potentiate chronic colitis and premalignant changes in interleukin 10 knockout mice. AN - 73598087; 12902846 AB - Nonsteroidal anti-inflammatory drugs decrease sporadic colorectal carcinoma and adenomas in patients with familial adenomatous polyposis and in rodent models of sporadic colon cancer and familial adenomatous polyposis. Similarly, selective cyclooxygenase 2 inhibitors decrease adenomas in humans and rodents. However, their effects on chronic colitis and colitis-associated neoplasia are unknown. Interleukin 10-/- mice (C57/B6) were fed regular chow (n = 20) or chow with celecoxib (1,500 ppm, n = 18) or rofecoxib (75 ppm, n = 20) for 12 weeks. Twenty-eight percent of the celecoxib group died versus 5% of the control and rofecoxib groups (p < 0.05 compared with control). Celecoxib and rofecoxib increased the incidence of colitis (26% vs. 92% and 68%, p < 0.01), colitis score (0.4 +/- 0.2 vs. 2.5 +/- 0.3 and 2 +/- 0.4, p < 0.01), aberrant crypt foci (0.5 +/- 0.3 vs. 3.7 +/- 2.6 and 2.8 +/- 0.7, p < 0.01), aberrant crypts per mouse (4.11 +/- 2.1 vs. 41.2 +/- 9.7 and 27.1 +/- 7.5, p < 0.01) and dysplasia (11% vs. 54% and 42%, p < 0.01). Similarly, indomethacin (9 ppm, n = 15) increased colitis score, aberrant crypt foci, and dysplasia after 27 days of treatment. Two selective cyclooxygenase 2 inhibitors exacerbate colitis and premalignant changes in the interleukin 10-/- mouse model of chronic colitis and colitis-associated colon carcinoma. JF - Inflammatory bowel diseases AU - Hegazi, Refaat A F AU - Mady, Hussam H AU - Melhem, Mona F AU - Sepulveda, Antonia R AU - Mohi, Mohamed AU - Kandil, Hossam M AD - Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center and Pittsburgh Veterans Administration Medical Center, Pittsburgh, Pennsylvania 15213, U.S.A. Y1 - 2003/07// PY - 2003 DA - July 2003 SP - 230 EP - 236 VL - 9 IS - 4 SN - 1078-0998, 1078-0998 KW - Cyclooxygenase Inhibitors KW - 0 KW - Lactones KW - Pyrazoles KW - Sulfonamides KW - Sulfones KW - rofecoxib KW - 0QTW8Z7MCR KW - Interleukin-10 KW - 130068-27-8 KW - Celecoxib KW - JCX84Q7J1L KW - Index Medicus KW - Animals KW - Colorectal Neoplasms -- pathology KW - Disease Models, Animal KW - Mice KW - Colorectal Neoplasms -- chemically induced KW - Immunohistochemistry KW - Mice, Knockout KW - Precancerous Conditions -- chemically induced KW - Cyclooxygenase Inhibitors -- toxicity KW - Interleukin-10 -- pharmacology KW - Sulfonamides -- toxicity KW - Colitis -- pathology KW - Colitis -- chemically induced KW - Lactones -- toxicity KW - Precancerous Conditions -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73598087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inflammatory+bowel+diseases&rft.atitle=Celecoxib+and+rofecoxib+potentiate+chronic+colitis+and+premalignant+changes+in+interleukin+10+knockout+mice.&rft.au=Hegazi%2C+Refaat+A+F%3BMady%2C+Hussam+H%3BMelhem%2C+Mona+F%3BSepulveda%2C+Antonia+R%3BMohi%2C+Mohamed%3BKandil%2C+Hossam+M&rft.aulast=Hegazi&rft.aufirst=Refaat+A&rft.date=2003-07-01&rft.volume=9&rft.issue=4&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Inflammatory+bowel+diseases&rft.issn=10780998&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-10-28 N1 - Date created - 2003-08-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adjuvant topiramate administration: a pharmacologic strategy for addressing NMDA receptor hypofunction in schizophrenia. AN - 73547417; 12897641 AB - N-methyl-d-aspartate receptor hypofunction (NRH) and its downstream consequences, especially excitotoxicity, may explain the progressive psychosocial deterioration and ventriculomegaly observed in at least some patients with schizophrenia. Topiramate has several properties that address downstream consequences of NRH. In this open-label investigation, the authors examined the salutary therapeutic effects of adjuvant topiramate in 12 patients with schizophrenia and schizoaffective disorder. Patients were selected on the basis of the presence of negative symptoms. An optimal dose of topiramate was determined for each patient during a slow 4-week titration process. Patients were maintained on topiramate and their stable antipsychotic medications for 8 weeks, after which topiramate was tapered and discontinued. Patients were followed for an additional 4 weeks on their stable antipsychotic medications. Clinical measures of efficacy (eg, Positive and Negative Syndrome Scale), cognitive measures (eg, verbal fluency, memory), and safety measures (eg, postural sway) were assessed throughout this study. Topiramate administration (average dose, 110.42 mg/day) decreased total scores on the Positive and Negative Syndrome Scale. Topiramate was also associated with a selective and reversible worsening of verbal fluency performance. These results encourage further testing of topiramate and kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonists in schizophrenia patients and support the heuristic model of NRH. JF - Clinical neuropharmacology AU - Deutsch, Stephen I AU - Schwartz, Barbara L AU - Rosse, Richard B AU - Mastropaolo, John AU - Marvel, Cherie L AU - Drapalski, Amy L AD - Mental Health Service Line, Veterans Affairs Medical Center, 50 Irving Street NW, Washington, DC 20422, USA. Stephen.Deutsch@med.va.gov PY - 2003 SP - 199 EP - 206 VL - 26 IS - 4 SN - 0362-5664, 0362-5664 KW - Receptors, N-Methyl-D-Aspartate KW - 0 KW - topiramate KW - 0H73WJJ391 KW - Fructose KW - 30237-26-4 KW - Index Medicus KW - Drug Therapy, Combination KW - Analysis of Variance KW - Humans KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Cognition Disorders -- chemically induced KW - Psychotic Disorders -- physiopathology KW - Male KW - Female KW - Psychotic Disorders -- drug therapy KW - Receptors, N-Methyl-D-Aspartate -- physiology KW - Fructose -- analogs & derivatives KW - Fructose -- adverse effects KW - Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors KW - Schizophrenia -- drug therapy KW - Fructose -- therapeutic use KW - Schizophrenia -- physiopathology KW - Fructose -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73547417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+neuropharmacology&rft.atitle=Adjuvant+topiramate+administration%3A+a+pharmacologic+strategy+for+addressing+NMDA+receptor+hypofunction+in+schizophrenia.&rft.au=Deutsch%2C+Stephen+I%3BSchwartz%2C+Barbara+L%3BRosse%2C+Richard+B%3BMastropaolo%2C+John%3BMarvel%2C+Cherie+L%3BDrapalski%2C+Amy+L&rft.aulast=Deutsch&rft.aufirst=Stephen&rft.date=2003-07-01&rft.volume=26&rft.issue=4&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Clinical+neuropharmacology&rft.issn=03625664&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-09-10 N1 - Date created - 2003-08-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interaction of rofecoxib and celecoxib with warfarin. AN - 73535761; 12901032 AB - The interaction of celecoxib and rofecoxib with warfarin was studied. Patients stable on warfarin therapy and concurrently taking a cyclooxygenase-2 (COX-2) inhibitor comparator (traditional nonsteroidal antiinflammatory medications, salsalate, or acetaminophen) randomly received celecoxib 200 mg/day or rofecoxib 25 mg/day for three weeks. After a one-week washout period, the patients were crossed over to treatment with the opposite COX-2 inhibitor for three more weeks. The International Normalized Ratio (INR) was measured at baseline and at weeks 1, 2, and 3 of therapy with each COX-2 inhibitor by testing blood samples obtained by finger stick. Data for 16 patients were analyzed. The INR increased by 13%, 6%, and 5% on average in patients taking celecoxib at weeks 1, 2, and 3, respectively, and by 5%, 9%, and 5% in patients taking rofecoxib. Changes in the INR were statistically significant at week 1 for celecoxib and at week 2 for rofecoxib. Of the 12 subjects who had a clinically significant > or = 15% change in the INR while receiving either COX-2 inhibitor, 4 showed this change for both agents. Adverse drug reactions were similar for each COX-2 inhibitor, but the rate of edema requiring medical intervention was higher in the rofecoxib group. Significant increases in the INR were observed in patients who were stable on warfarin therapy after the addition of therapy with rofecoxib or celecoxib. JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Schaefer, Monica G AU - Plowman, Brian K AU - Morreale, Anthony P AU - Egan, Melissa AD - VA San Diego Healthcare System, Pharmacy (119), 3350 La Jolla Village Drive, San Diego, CA 92161, USA. monica.schaefer@med.va.gov Y1 - 2003/07/01/ PY - 2003 DA - 2003 Jul 01 SP - 1319 EP - 1323 VL - 60 IS - 13 SN - 1079-2082, 1079-2082 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Anticoagulants KW - Cyclooxygenase 2 Inhibitors KW - Cyclooxygenase Inhibitors KW - Isoenzymes KW - Lactones KW - Membrane Proteins KW - Pyrazoles KW - Sulfonamides KW - Sulfones KW - rofecoxib KW - 0QTW8Z7MCR KW - Warfarin KW - 5Q7ZVV76EI KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Celecoxib KW - JCX84Q7J1L KW - Index Medicus KW - Humans KW - International Normalized Ratio KW - Aged KW - Isoenzymes -- antagonists & inhibitors KW - Prospective Studies KW - Cross-Over Studies KW - Drug Synergism KW - Female KW - Male KW - Lactones -- adverse effects KW - Cyclooxygenase Inhibitors -- adverse effects KW - Sulfonamides -- adverse effects KW - Sulfonamides -- pharmacology KW - Anticoagulants -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Warfarin -- adverse effects KW - Lactones -- pharmacology KW - Cyclooxygenase Inhibitors -- pharmacology KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73535761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Interaction+of+rofecoxib+and+celecoxib+with+warfarin.&rft.au=Schaefer%2C+Monica+G%3BPlowman%2C+Brian+K%3BMorreale%2C+Anthony+P%3BEgan%2C+Melissa&rft.aulast=Schaefer&rft.aufirst=Monica&rft.date=2003-07-01&rft.volume=60&rft.issue=13&rft.spage=1319&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=10792082&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-11-06 N1 - Date created - 2003-08-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Population-based maximum tolerated dose of irinotecan and carboplatin. AN - 73522034; 12886868 AB - A novel schema of intrapatient dose escalation was applied to determine a population-based maximum tolerated dose (pMTD) for irinotecan (CPT-11, Camptosar) and carboplatin (Paraplatin) in a phase I trial. A total of 74 patients with advanced solid tumors were enrolled with the following characteristics: men/women, 46/28; median age, 61 years; 51 patients with and 23 patients without prior chemotherapy; performance status of 0-1 (93%) and 2 (7%). Patients were started at dose level 1 with irinotecan at 200 mg/m2, and carboplatin at an area under the concentration-time curve (AUC) of 5 mg/mL x min, administered every 21 days. Depending on degree of toxicity observed, the dose for each patient in each subsequent cycle was determined according to a predetermined schema of dose levels. Individual maximum tolerated dose (iMTD) was determined for each patient. The pMTD was defined as the highest dose level for which the incidence of dose-limiting toxicity occurred in less than 33% of the patient population. The most common dose-limiting toxicity included neutropenia (58%), thrombocytopenia (15%), diarrhea (8%), and nausea/emesis (7%). The iMTD ranged from dose level-3 (irinotecan at 100 mg/m2 and carboplatin at an AUC of 4) to dose level 5 (irinotecan at 350 mg/m2 and carboplatin at AUC 6). The pMTD was determined to be dose level-1 and 1 for previously chemotherapy-treated and--untreated patients, respectively. Fifty-nine patients were assessable for response. Of note, a response rate of 40% was observed in 15 patients with relapsed small-cell lung cancer previously treated with platinum-based therapy. We recommend dose level 1 of irinotecan (200 mg/m2) and carboplatin (AUC 5) for chemotherapynaive patients, and dose level-1 of irinotecan (150 mg/m2) and carboplatin (AUC 5) for chemotherapy-treated patients in phase II trials. JF - Oncology (Williston Park, N.Y.) AU - Wild, Carolyn A AU - Wang, Stephen E AU - Gandara, David R AU - Lara, Primo N AU - Meyers, Frederick J AU - Tanaka, Michael AU - Houston, Joan AU - Lauder, Jun AU - Lau, Derick H AD - University of California, Davis Cancer Center, Veterans Administration, Northern California Health Care System, Sacramento, California, USA. Y1 - 2003/07// PY - 2003 DA - July 2003 SP - 11 EP - 16 VL - 17 IS - 7 Suppl 7 SN - 0890-9091, 0890-9091 KW - irinotecan KW - 0H43101T0J KW - Carboplatin KW - BG3F62OND5 KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Neoplasms -- drug therapy KW - Drug Administration Schedule KW - Area Under Curve KW - Dose-Response Relationship, Drug KW - Humans KW - Aged KW - Carboplatin -- administration & dosage KW - Carboplatin -- adverse effects KW - Aged, 80 and over KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Female KW - Male KW - Camptothecin -- analogs & derivatives KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Maximum Tolerated Dose KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Camptothecin -- adverse effects KW - Camptothecin -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73522034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+%28Williston+Park%2C+N.Y.%29&rft.atitle=Population-based+maximum+tolerated+dose+of+irinotecan+and+carboplatin.&rft.au=Wild%2C+Carolyn+A%3BWang%2C+Stephen+E%3BGandara%2C+David+R%3BLara%2C+Primo+N%3BMeyers%2C+Frederick+J%3BTanaka%2C+Michael%3BHouston%2C+Joan%3BLauder%2C+Jun%3BLau%2C+Derick+H&rft.aulast=Wild&rft.aufirst=Carolyn&rft.date=2003-07-01&rft.volume=17&rft.issue=7+Suppl+7&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Oncology+%28Williston+Park%2C+N.Y.%29&rft.issn=08909091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-10-23 N1 - Date created - 2003-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of a minimal services treatment track for noncompliant patients in opioid substitution treatment. AN - 73441639; 12835190 JF - American journal of public health AU - Calsyn, Donald A AU - DeMarco, Frank J AU - Saxon, Andrew J AU - Sloan, Kevin L AU - Gibbon, Karen E AD - Addictions Treatment Center, Veterans Affairs Puget Sound Health Care System and the University of Washington School of Medicine, Seattle, 98108, USA. donald.calsyn@med.va.gov Y1 - 2003/07// PY - 2003 DA - July 2003 SP - 1086 EP - 1088 VL - 93 IS - 7 SN - 0090-0036, 0090-0036 KW - Methadone KW - UC6VBE7V1Z KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Washington KW - Methadone -- therapeutic use KW - Drug and Narcotic Control KW - United States Department of Veterans Affairs KW - Humans KW - Veterans -- psychology KW - Program Evaluation KW - Substance Abuse Treatment Centers -- organization & administration KW - Opioid-Related Disorders -- drug therapy KW - Health Services Accessibility -- organization & administration KW - Treatment Refusal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73441639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Evaluation+of+a+minimal+services+treatment+track+for+noncompliant+patients+in+opioid+substitution+treatment.&rft.au=Calsyn%2C+Donald+A%3BDeMarco%2C+Frank+J%3BSaxon%2C+Andrew+J%3BSloan%2C+Kevin+L%3BGibbon%2C+Karen+E&rft.aulast=Calsyn&rft.aufirst=Donald&rft.date=2003-07-01&rft.volume=93&rft.issue=7&rft.spage=1086&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-06 N1 - Date created - 2003-07-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Addict. 1985 Jun-Jul;20(6-7):803-21 [3908338] Arch Gen Psychiatry. 1987 Mar;44(3):281-4 [3827521] Am Psychol. 1998 Nov;53(11):1199-208 [9830372] J Nerv Ment Dis. 1991 Apr;179(4):222-7 [2007893] J Addict Dis. 1994;13(3):47-63 [7734459] J Health Soc Behav. 1988 Sep;29(3):214-26 [3241064] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of nicotine deprivation on urges to drink and smoke in alcoholic smokers. AN - 73438174; 12814497 AB - This study examined the effect of nicotine deprivation on alcohol and smoking urges in a sample of alcohol-dependent smokers in early recovery. Using a within-subjects design, participants underwent two cue-reactivity laboratory sessions in which they rated their urges for alcohol and cigarettes during the following three trials: baseline, neutral cue and mood induction combined with alcohol beverage cue exposure. One session was completed after 34 hours of nicotine deprivation and another in a non-deprived state. Forty alcohol-dependent heavy smokers recruited from a substance abuse day treatment program. Self-reported urge to drink, urge to smoke and salivation. Results showed that during the non-deprived session, alcohol cue presentations were associated with significant increases in urges to drink and urges to smoke. Acute nicotine deprivation led to increased smoking urges, but was not associated with increased urges to drink alcohol. Findings suggest that the acute effects of smoking cessation are unlikely to increase risk of relapse to alcohol in alcoholic patients who are undergoing treatment. JF - Addiction (Abingdon, England) AU - Cooney, Judith L AU - Cooney, Ned L AU - Pilkey, David T AU - Kranzler, Henry R AU - Oncken, Cheryl A AD - VA Connecticut Healthcare System, Newington, CT, USA. judith.cooney@med.va.gov Y1 - 2003/07// PY - 2003 DA - July 2003 SP - 913 EP - 921 VL - 98 IS - 7 SN - 0965-2140, 0965-2140 KW - Nicotinic Agonists KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Carbon Monoxide KW - 7U1EE4V452 KW - Cotinine KW - K5161X06LL KW - Index Medicus KW - Salivation KW - Carbon Monoxide -- analysis KW - Imagery (Psychotherapy) KW - Humans KW - Adult KW - Cues KW - Cotinine -- blood KW - Substance Withdrawal Syndrome -- psychology KW - Middle Aged KW - Male KW - Female KW - Breath Tests KW - Alcoholism -- rehabilitation KW - Motivation KW - Nicotinic Agonists -- blood KW - Nicotine -- adverse effects KW - Nicotine -- blood KW - Smoking -- psychology KW - Nicotinic Agonists -- adverse effects KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73438174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Effects+of+nicotine+deprivation+on+urges+to+drink+and+smoke+in+alcoholic+smokers.&rft.au=Cooney%2C+Judith+L%3BCooney%2C+Ned+L%3BPilkey%2C+David+T%3BKranzler%2C+Henry+R%3BOncken%2C+Cheryl+A&rft.aulast=Cooney&rft.aufirst=Judith&rft.date=2003-07-01&rft.volume=98&rft.issue=7&rft.spage=913&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-09-16 N1 - Date created - 2003-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase 1 study of the intravesical administration of recombinant human interleukin-12 in patients with recurrent superficial transitional cell carcinoma of the bladder. AN - 73431023; 12843796 AB - Superficial transitional cell carcinoma (STCC) of the bladder is usually managed with intravesical bacille Calmette-Guerin. Recombinant human interleukin-12 (rhIL-12) is a heterodimeric cytokine that induces T-cell and natural killer cell proliferation/activation and production of IFNgamma. It has demonstrated preclinical in vivo bladder antitumor activity and no systemic toxicity. This phase 1 study evaluated intravesical rhIL-12 administration in patients with STCC (Tis, Ta, or T1) who had failed at least one prior intravesical therapy or had at least two recurrences of low-grade tumors. Eligible patients had adequate hematologic, renal, and hepatic function and Karnofsky performance status at least 70%. Cohorts of three patients received 5, 20, 50, 100, and 200 microg rhIL-12 (treated n = 15). Each patient received intravesical rhIL-12 weekly for 6 weeks, with a 2-hour bladder dwell. No patient experienced moderate, severe, or life-threatening systemic toxicity. Treatment-related adverse events included dysuria, urinary frequency, urinary urgency, asthenia, pain, hematuria, bladder spasms, and chills. Specific AE incidences were not dose-related. Among 12 patients without visible pretreatment lesions, 7 remained disease-free and 5 experienced recurrence of STCC within the 4-week follow-up period. Three patients with pretreatment Tis or Ta/T1 lesions had persistent disease at posttreatment follow-up. No patients with persistent tumor manifested antitumor response to rhIL-12. Two-hour dwell urine samples and 24- to 30-hour postdose serum samples showed negligible induction of IFNgamma. In summary, intravesical rhIL-12 was well tolerated by patients with recurrent STCC but showed no clinically relevant evidence of antitumor or immunologic effects. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Weiss, Geoffrey R AU - O'Donnell, Michael A AU - Loughlin, Kevin AU - Zonno, Kristilyn AU - Laliberte, Robert J AU - Sherman, Matthew L AD - The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA. GEOFFREY.WEISS@med.va.gov PY - 2003 SP - 343 EP - 348 VL - 26 IS - 4 SN - 1524-9557, 1524-9557 KW - Recombinant Proteins KW - 0 KW - Interleukin-12 KW - 187348-17-0 KW - Index Medicus KW - Urinary Bladder -- pathology KW - Dose-Response Relationship, Drug KW - Dimerization KW - Humans KW - Aged KW - Administration, Intravesical KW - Aged, 80 and over KW - Cohort Studies KW - Middle Aged KW - Time Factors KW - Female KW - Male KW - Cell Division KW - Interleukin-12 -- administration & dosage KW - Urinary Bladder Neoplasms -- drug therapy KW - Recombinant Proteins -- chemistry KW - Interleukin-12 -- therapeutic use KW - Recombinant Proteins -- therapeutic use KW - Recombinant Proteins -- administration & dosage KW - Carcinoma, Transitional Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73431023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Phase+1+study+of+the+intravesical+administration+of+recombinant+human+interleukin-12+in+patients+with+recurrent+superficial+transitional+cell+carcinoma+of+the+bladder.&rft.au=Weiss%2C+Geoffrey+R%3BO%27Donnell%2C+Michael+A%3BLoughlin%2C+Kevin%3BZonno%2C+Kristilyn%3BLaliberte%2C+Robert+J%3BSherman%2C+Matthew+L&rft.aulast=Weiss&rft.aufirst=Geoffrey&rft.date=2003-07-01&rft.volume=26&rft.issue=4&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=15249557&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-23 N1 - Date created - 2003-07-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Five-year outcomes following psychiatric consultation to a tertiary care emergency room. AN - 73403198; 12832256 AB - The authors prospectively examined inpatient psychiatric hospitalization and mortality rates of psychiatric patients seen in the emergency room of a large Department of Veterans Affairs medical center. Charts of 504 patients receiving evening psychiatric consultation during a 13-month period were assessed 5 years after the consultation to determine rates of psychiatric hospitalization and mortality. Patients with multiple psychiatric diagnoses, including comorbid addiction disorders, had significantly higher rates of psychiatric hospitalization 5 years after an emergency room visit. Comorbid psychiatric disorders increased the rate of inpatient psychiatric hospitalization across diagnoses. Seventy-eight patients died during the study period. These findings reveal relationships between diagnostic profiles and future psychiatric hospitalization and mortality rates. This information could focus psychiatric and medical interventions for high-risk patients. JF - The American journal of psychiatry AU - Lambert, Michael T AU - LePage, James P AU - Schmitt, Andrew L AD - Department of Psychiatry, University of Texas Southwestern Medical School at Dallas, TX 75216, USA. Michael.Lambert2@med.va.gov Y1 - 2003/07// PY - 2003 DA - July 2003 SP - 1350 EP - 1353 VL - 160 IS - 7 SN - 0002-953X, 0002-953X KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Prospective Studies KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Substance-Related Disorders -- mortality KW - Outcome Assessment (Health Care) KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Referral and Consultation -- statistics & numerical data KW - Mental Disorders -- diagnosis KW - Mental Disorders -- therapy KW - Emergency Service, Hospital -- statistics & numerical data KW - Emergency Service, Hospital -- utilization KW - Hospitals, Veterans -- statistics & numerical data KW - Hospitals, Psychiatric -- statistics & numerical data KW - Hospitalization -- statistics & numerical data KW - Mental Disorders -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73403198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Five-year+outcomes+following+psychiatric+consultation+to+a+tertiary+care+emergency+room.&rft.au=Lambert%2C+Michael+T%3BLePage%2C+James+P%3BSchmitt%2C+Andrew+L&rft.aulast=Lambert&rft.aufirst=Michael&rft.date=2003-07-01&rft.volume=160&rft.issue=7&rft.spage=1350&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-29 N1 - Date created - 2003-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase II study of vinorelbine with low dose prednisone in the treatment of hormone-refractory metastatic prostate cancer. AN - 73397978; 12792740 AB - A phase II trial of vinorelbine and low dose prednisone in hormone-refractory metastatic prostate cancer was conducted in order to investigate its safety, efficacy and impact on quality of life. Vinorelbine was administered at the dose of 25 mg/m(2) i.v. weekly for 12 weeks and then biweekly, along with 10 mg of daily oral prednisone until time of progression. Fourteen patients, median age of 74 years, were treated. The treatment was generally well tolerated with leukopenia and anemia as the major side effects. One patient achieved partial remission and eleven remained with stable disease. One of the eleven patients with stable disease had a dramatic PSA response from 1000 to 236 ng/ml; seven of these progressed after week twelve when vinorelbine was given biweekly. PSA response occurred in 5 of 14 patients. The median time to progression was 28 weeks and the median survival was 17 months. Nine out of the 14 accrued patients were evaluable for quality of life assessment. Five of them improved, three remained unchanged and two had a slight worsening. Four patients had improvement in pain control and fatigue. Our preliminary data suggest that the combination of vinorelbine/prednisone has modest activity in metastatic prostate cancer with a very favorable toxicity profile and is very well tolerated in this group of elderly patients. JF - Oncology reports AU - Robles, C AU - Furst, A J AU - Sriratana, P AU - Lai, S AU - Chua, L AU - Donnelly, E AU - Solomon, J AU - Sundaram, M AU - Feun, L AU - Savaraj, N AD - VA Medical Center, 1201 NW 16th Avenue D1010 (111k), Miami, FL 33125, USA. carlos.robles@med.va.gov PY - 2003 SP - 885 EP - 889 VL - 10 IS - 4 SN - 1021-335X, 1021-335X KW - Vinblastine KW - 5V9KLZ54CY KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - vinorelbine KW - Q6C979R91Y KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Aged, 80 and over KW - Prostate-Specific Antigen -- metabolism KW - Humans KW - Bone Neoplasms -- drug therapy KW - Treatment Outcome KW - Aged KW - Adenocarcinoma -- secondary KW - Middle Aged KW - Adenocarcinoma -- drug therapy KW - Prednisone -- administration & dosage KW - Male KW - Bone Neoplasms -- secondary KW - Prostatic Neoplasms -- pathology KW - Vinblastine -- analogs & derivatives KW - Vinblastine -- administration & dosage KW - Neoplasms, Hormone-Dependent -- drug therapy KW - Prostatic Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73397978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+reports&rft.atitle=Phase+II+study+of+vinorelbine+with+low+dose+prednisone+in+the+treatment+of+hormone-refractory+metastatic+prostate+cancer.&rft.au=Robles%2C+C%3BFurst%2C+A+J%3BSriratana%2C+P%3BLai%2C+S%3BChua%2C+L%3BDonnelly%2C+E%3BSolomon%2C+J%3BSundaram%2C+M%3BFeun%2C+L%3BSavaraj%2C+N&rft.aulast=Robles&rft.aufirst=C&rft.date=2003-07-01&rft.volume=10&rft.issue=4&rft.spage=885&rft.isbn=&rft.btitle=&rft.title=Oncology+reports&rft.issn=1021335X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-06 N1 - Date created - 2003-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - LDL immune complexes stimulate LDL receptor expression in U937 histiocytes via extracellular signal-regulated kinase and AP-1. AN - 73353884; 12730303 AB - We have previously shown that LDL-containing immune complexes (LDL-ICs) induce up-regulation of LDL receptor (LDLR) expression in human macrophages. The present study further investigated the molecular mechanisms leading to LDLR up-regulation by LDL-ICs as well as the signaling pathways involved. Results showed that treatment of U937 histiocytes with LDL-ICs did not increase the precursors and the cleaved forms of sterol-regulatory element binding proteins (SREBPs) 1a and 2, suggesting that SREBPs may not be involved in LDLR up-regulation by LDL-ICs. Promoter deletion and mutation studies showed that the AP-1 binding sites were essential for LDL-IC-stimulated LDLR expression. Electrophoretic mobility shift assays further demonstrated that LDL-ICs stimulated transcription factor AP-1 activity. Studies assessing the signaling pathways involved in LDLR up-regulation by LDL-ICs showed that the up-regulation of LDLR was extracellular signal-regulated kinase (ERK) dependent. In conclusion, the present study shows that LDL-ICs up-regulate LDLR expression via the ERK signaling pathway and the AP-1 motif-dependent transcriptional activation. JF - Journal of lipid research AU - Fu, Yuchang AU - Huang, Yan AU - Bandyopadhyay, Sumita AU - Virella, Gabriel AU - Lopes-Virella, Maria F AD - Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC 29401, USA. Y1 - 2003/07// PY - 2003 DA - July 2003 SP - 1315 EP - 1321 VL - 44 IS - 7 SN - 0022-2275, 0022-2275 KW - CCAAT-Enhancer-Binding Proteins KW - 0 KW - DNA-Binding Proteins KW - Lipoproteins, LDL KW - SREBF1 protein, human KW - Sterol Regulatory Element Binding Protein 1 KW - Transcription Factor AP-1 KW - Transcription Factors KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Humans KW - Transcription, Genetic KW - Reverse Transcriptase Polymerase Chain Reaction KW - Protein Binding KW - Transcriptional Activation KW - Gene Deletion KW - Mutagenesis KW - Blotting, Western KW - Promoter Regions, Genetic KW - Transfection KW - Models, Genetic KW - CCAAT-Enhancer-Binding Proteins -- metabolism KW - Genes, Reporter KW - Up-Regulation KW - Mutation KW - Signal Transduction KW - U937 Cells KW - DNA-Binding Proteins -- metabolism KW - Macrophages -- metabolism KW - Transcription Factor AP-1 -- metabolism KW - Mitogen-Activated Protein Kinases -- metabolism KW - Lipoproteins, LDL -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73353884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+lipid+research&rft.atitle=LDL+immune+complexes+stimulate+LDL+receptor+expression+in+U937+histiocytes+via+extracellular+signal-regulated+kinase+and+AP-1.&rft.au=Fu%2C+Yuchang%3BHuang%2C+Yan%3BBandyopadhyay%2C+Sumita%3BVirella%2C+Gabriel%3BLopes-Virella%2C+Maria+F&rft.aulast=Fu&rft.aufirst=Yuchang&rft.date=2003-07-01&rft.volume=44&rft.issue=7&rft.spage=1315&rft.isbn=&rft.btitle=&rft.title=Journal+of+lipid+research&rft.issn=00222275&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-17 N1 - Date created - 2003-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A word-recognition task in multitalker babble using a descending presentation mode from 24 dB to 0 dB signal to babble. AN - 71576060; 15074443 AB - A speech-in-multitalker-babble test instrument was developed for use in a Department of Veterans Affairs (VA) multicenter study examining the effects of hearing loss on self-perceived quality of life. Word recognition in quiet and in multitalker babble was measured on 24 listeners with normal hearing and 24 listeners with sensorineural hearing loss. The protocol involved the presentation of 10 monosyllabic words (each in a unique babble segment) at each of seven signal-to-babble (S/B) ratios from 24 dB to 0 dB, with the babble fixed at 60 dB HL (hearing loss). Word recognition in quiet at 60 dB and 80 dB HL for both groups was >90% correct. Two trials on the task were conducted. In babble, the 50% correct points were at 4.1 dB and 9.4 dB S/B for the listeners with normal hearing and hearing loss, respectively, with the 90th percentile for the listeners with normal hearing at 6 dB S/B. Twenty-two of the twenty-four listeners with hearing loss had 50% correct points outside of the 90th percentile for listeners with normal hearing. Test-retest reliability was excellent. JF - Journal of rehabilitation research and development AU - Wilson, Richard H AU - Abrams, Harvey B AU - Pillion, Amanda L AD - James H. Quillen Department of Veterans Affairs (VA) Medical Center, Mountain Home, TN 37684, USA. richard.wilson2@med.va.gov PY - 2003 SP - 321 EP - 327 VL - 40 IS - 4 SN - 0748-7711, 0748-7711 KW - Index Medicus KW - Humans KW - Noise KW - Task Performance and Analysis KW - Psychometrics KW - Hearing Loss, Sensorineural -- rehabilitation KW - Auditory Perception UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71576060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+rehabilitation+research+and+development&rft.atitle=A+word-recognition+task+in+multitalker+babble+using+a+descending+presentation+mode+from+24+dB+to+0+dB+signal+to+babble.&rft.au=Wilson%2C+Richard+H%3BAbrams%2C+Harvey+B%3BPillion%2C+Amanda+L&rft.aulast=Wilson&rft.aufirst=Richard&rft.date=2003-07-01&rft.volume=40&rft.issue=4&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Journal+of+rehabilitation+research+and+development&rft.issn=07487711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-13 N1 - Date created - 2004-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Postoperative pain guidelines AN - 205112603; 12945020 AB - BACKGROUND AND OBJECTIVES: Postoperative pain is the expected but nonetheless undesirable byproduct of all surgical procedures. Humanitarian concerns and recent quasi-governmental regulations have heightened awareness about the importance of treating postoperative pain. This guideline builds upon the foundation created by the Agency for Health Care Policy and Research guideline published in 1993, highlights changes that have occurred over the past 10 years, and makes recommendations based on the current scientific evidence. In addition, it takes advantage of the versatile information management inherent in a web-based format to make the information readily available. METHODS: A multidisciplinary group of physicians, dentists, nurses, pharmacists, physical therapists, psychologists, and ethicists from the Veterans Health Administration (VHA) and Department of Defense (DoD) in conjunction with the VHA Office of Quality and Performance and a consultant group developed a postoperative pain algorithm and supporting documentation. The guideline structure and content were determined by a standardized rating of the evidence gleaned from comprehensive electronic searches. RESULTS: An interactive electronic and traditional "paper" guideline with a pre- and postoperative algorithm was developed. A table, which provides a menu of analgesic choices organized by specific operation, was constructed. Preferences for particular analgesic techniques and classes of medications were identified. A postoperative pain interactive pharmacopoeia and printable patient educational materials were also provided. The guideline may be reviewed at the following website: www.oqp.med.va.gov/cpg/cpg.htm. CONCLUSIONS: This postoperative pain guideline provides readily accessible information and evidence-based guidance to a variety of providers. It highlights deficiencies in our understanding of the pain and recovery processes and how they might guide our choices of postoperative analgesic techniques. In combination with the powerful system-wide data collection capabilities of the VHA, there may be improved understanding of what techniques are useful. Finally, it may lead to the development of reliable, individualized analgesic plans for specific surgical procedures that incorporate the full range of pharmacologic and nonpharmacologic techniques. JF - Regional Anesthesia and Pain Medicine AU - Rosenquist, Richard W AU - Rosenberg, Jack Y1 - 2003///Jul/Aug PY - 2003 DA - Jul/Aug 2003 SP - 279 EP - 88 CY - Secaucus PB - Lippincott Williams & Wilkins VL - 28 IS - 4 SN - 10987339 KW - Medical Sciences--Anaesthesiology KW - Analgesics KW - Drug Delivery Systems KW - Evidence-Based Medicine KW - Cognitive Therapy KW - Humans KW - Pain, Postoperative -- drug therapy KW - Algorithms KW - Cold Temperature KW - Transcutaneous Electric Nerve Stimulation KW - Analgesics -- administration & dosage KW - Analgesics -- therapeutic use KW - Quality Assurance, Health Care KW - Anesthesia, Conduction KW - Pain, Postoperative -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/205112603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regional+Anesthesia+and+Pain+Medicine&rft.atitle=Postoperative+pain+guidelines&rft.au=Rosenquist%2C+Richard+W%3BRosenberg%2C+Jack&rft.aulast=Rosenquist&rft.aufirst=Richard&rft.date=2003-07-01&rft.volume=28&rft.issue=4&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Regional+Anesthesia+and+Pain+Medicine&rft.issn=10987339&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Churchill Livingstone Inc., Medical Publishers Jul/Aug 2003 N1 - Last updated - 2014-05-18 ER - TY - JOUR T1 - Quadriceps Fatigability after Single Muscle Exercise in Patients with Chronic Obstructive Pulmonary Disease AN - 17703976; 5980647 AB - The purpose of this study was to compare quadriceps fatigability in patients with varying severity of chronic obstructive pulmonary disease with age-matched control subjects. Ten healthy control subjects, 8 patients with severe disease (FEV sub(1) less than 35% predicted), and 11 patients with mild to moderate disease were studied. The FEV sub(1) was 1.75 plus or minus 0.13 L (SE), 50.4 plus or minus 2.9% of predicted in the mild to moderate group, and 0.87 plus or minus 0.06 L, 25.9 plus or minus 1.9% of predicted in the severe group. Quadriceps fatigue was quantified by the reduction in potentiated twitch force after a potentially fatiguing task. All subjects performed three sets of 10 maximum voluntary contractions of the right quadriceps muscle. Quadriceps maximum voluntary contraction force was 58.3 plus or minus 3.3 kg for the healthy older group, 49.0 plus or minus 4.2 kg in the mild to moderate group, and 44.3 plus or minus 4.7 kg in the severe group. The fall in potentiated twitch force after exercise was significantly greater in the patients with severe disease than in the healthy control subjects. In conclusion, the quadriceps in patients with severe chronic obstructive pulmonary disease are more fatigable than those in age- and sex-matched healthy control subjects. JF - American Journal of Respiratory and Critical Care Medicine AU - Mador, MJ AU - Deniz, O AU - Aggarwal, A AU - Kufel, T J AD - Division of Pulmonary, Critical Care and Sleep Medicine, Section 111S, State University of New York at Buffalo, Veterans Administration Medical Center, 3495 Bailey Avenue, Buffalo, NY 14215, USA, mador@acsu.buffalo.edu Y1 - 2003/07/01/ PY - 2003 DA - 2003 Jul 01 SP - 102 EP - 108 VL - 168 IS - 1 SN - 0003-0805, 0003-0805 KW - Physical Education Index KW - Muscles (exercise effects) KW - Lungs KW - Muscles (fatigue) KW - Diseases KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17703976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Quadriceps+Fatigability+after+Single+Muscle+Exercise+in+Patients+with+Chronic+Obstructive+Pulmonary+Disease&rft.au=Mador%2C+MJ%3BDeniz%2C+O%3BAggarwal%2C+A%3BKufel%2C+T+J&rft.aulast=Mador&rft.aufirst=MJ&rft.date=2003-07-01&rft.volume=168&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=00030805&rft_id=info:doi/10.1164%2Frccm.200202-080OC LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Muscles (exercise effects); Lungs; Diseases; Muscles (fatigue) DO - http://dx.doi.org/10.1164/rccm.200202-080OC ER - TY - JOUR T1 - Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells. AN - 73362872; 12794122 AB - Lipopolysaccharide (endotoxin) tolerance is well described in monocytes and macrophages, but is less well characterized in endothelial cells. Because intestinal microvascular endothelial cells exhibit a strong immune response to LPS challenge and play a critical regulatory role in gut inflammation, we sought to characterize the activation response of these cells to repeated LPS exposure. Primary cultures of human intestinal microvascular endothelial cells (HIMEC) were stimulated with LPS over 6-60 h and activation was assessed using U937 leukocyte adhesion, expression of E-selectin, ICAM-1, VCAM-1, IL-6, IL-8, manganese superoxide dismutase, HLA-DR, and CD86. Effect of repeat LPS stimulation on HIMEC NF-kappaB and mitogen-activated protein kinase (MAPK) activation, generation of superoxide anion, and Toll-like receptor 4 expression was characterized. LPS pretreatment of HIMEC for 24-48 h significantly decreased leukocyte adhesion after subsequent LPS stimulation. LPS pretreatment inhibited expression of E-selectin, VCAM-1, IL-6, and CD86, while ICAM-1, IL-8, and HLA-DR were not altered. Manganese superoxide dismutase expression increased with repeated LPS stimulation, with a reduction in intracellular superoxide. NF-kappaB activation was transiently inhibited by LPS pretreatment for 6 h, but not at later time points. In contrast, p44/42 MAPK, p38 MAPK, and c-Jun N-terminal kinase activation demonstrated inhibition by LPS pretreatment 24 or 48 h prior. Toll-like receptor 4 expression on HIMEC was not altered by LPS. HIMEC exhibit endotoxin tolerance after repeat LPS exposure in vitro, characterized by diminished activation and intracellular superoxide anion concentration, and reduced leukocyte adhesion. HIMEC possess specific mechanisms of immunoregulatory hyporesponsiveness to repeated LPS exposure. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Ogawa, Hitoshi AU - Rafiee, Parvaneh AU - Heidemann, Jan AU - Fisher, Pamela J AU - Johnson, Nathan A AU - Otterson, Mary F AU - Kalyanaraman, Balaraman AU - Pritchard, Kirkwood A AU - Binion, David G AD - Division of Gastroenterology and Hepatology, Department of Surgery, Milwaukee Veterans Administration Medical Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Y1 - 2003/06/15/ PY - 2003 DA - 2003 Jun 15 SP - 5956 EP - 5964 VL - 170 IS - 12 SN - 0022-1767, 0022-1767 KW - Adjuvants, Immunologic KW - 0 KW - Antibodies, Monoclonal KW - Cell Adhesion Molecules KW - Cytokines KW - Lipopolysaccharides KW - Membrane Glycoproteins KW - NF-kappa B KW - Reactive Oxygen Species KW - Receptors, Cell Surface KW - TLR4 protein, human KW - Toll-Like Receptor 4 KW - Toll-Like Receptors KW - Superoxides KW - 11062-77-4 KW - Abridged Index Medicus KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Microcirculation -- pathology KW - Cell Adhesion Molecules -- immunology KW - Humans KW - Cytokines -- secretion KW - MAP Kinase Signaling System -- immunology KW - Microcirculation -- immunology KW - Superoxides -- antagonists & inhibitors KW - Superoxides -- metabolism KW - Adjuvants, Immunologic -- toxicity KW - Cell Membrane -- immunology KW - Intracellular Fluid -- immunology KW - Immunity, Mucosal -- immunology KW - Microcirculation -- metabolism KW - Cell Adhesion Molecules -- biosynthesis KW - NF-kappa B -- antagonists & inhibitors KW - Microcirculation -- enzymology KW - Reactive Oxygen Species -- immunology KW - Antibodies, Monoclonal -- metabolism KW - Intracellular Fluid -- metabolism KW - Receptors, Cell Surface -- biosynthesis KW - Membrane Glycoproteins -- biosynthesis KW - Dose-Response Relationship, Immunologic KW - Binding, Competitive -- immunology KW - Cell Adhesion -- immunology KW - Inflammation -- immunology KW - Inflammation -- metabolism KW - Cell Membrane -- metabolism KW - Binding Sites, Antibody KW - Cell Line KW - U937 Cells KW - NF-kappa B -- metabolism KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- enzymology KW - Lipopolysaccharides -- immunology KW - Intestinal Mucosa -- immunology KW - Intestinal Mucosa -- enzymology KW - Endothelium, Vascular -- pathology KW - Lipopolysaccharides -- toxicity KW - Intestinal Mucosa -- pathology KW - Intestinal Mucosa -- metabolism KW - Immune Tolerance KW - Endothelium, Vascular -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73362872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Mechanisms+of+endotoxin+tolerance+in+human+intestinal+microvascular+endothelial+cells.&rft.au=Ogawa%2C+Hitoshi%3BRafiee%2C+Parvaneh%3BHeidemann%2C+Jan%3BFisher%2C+Pamela+J%3BJohnson%2C+Nathan+A%3BOtterson%2C+Mary+F%3BKalyanaraman%2C+Balaraman%3BPritchard%2C+Kirkwood+A%3BBinion%2C+David+G&rft.aulast=Ogawa&rft.aufirst=Hitoshi&rft.date=2003-06-15&rft.volume=170&rft.issue=12&rft.spage=5956&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-09-08 N1 - Date created - 2003-06-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Approaches to Speech-Language Intervention and the True Believer: A Response AN - 85627547; 200510708 AB - Commentary on Frederic A. Gruber et al's "Approaches to Speech-Language Intervention and the True Believer" (Journal of Medical Speech-Language Pathology, 2003, 11, 2, 95-104) addresses in turn each of the five extraneous sources of bias in treatment outcomes research identified by Gruber et al & their proposals for controlling each type of bias. (1) It is argued that randomized controlled trials provide the only effective control for the placebo effect; ethical reservations can be mitigated by treating the no-treatment S group immediately after the study. (2) The Hawthorne effect is not eliminated by a comparison of treatments design or a single-S design as Gruber et al suggest. (3) Natural effects of time can be equated between groups by random assignment to treatment & no-treatment conditions. (4) Although a double-blind study is impossible in behavioral treatment research, the experimenter effect can be controlled by outside scoring of outcome measures from videotape recordings. (5) Potential controls are noted for regression effects in the absence of knowledge of the true mean for the population of communicative disorders. 9 References. J. Hitchcock JF - Journal of Medical Speech-Language Pathology AU - Wertz, Robert T AD - VA Tennessee Valley Healthcare System, Nashville robert.wertz@med.va.gov Y1 - 2003/06// PY - 2003 DA - June 2003 SP - 105 EP - 109 VL - 11 IS - 2 SN - 1065-1438, 1065-1438 KW - Diagnosis (18540) KW - Judgment (39900) KW - Language Therapy (44400) KW - Videotape Recordings (94000) KW - Health Care Practitioners (31130) KW - Research Design (72950) KW - Speech Therapy (83200) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85627547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Speech-Language+Pathology&rft.atitle=Approaches+to+Speech-Language+Intervention+and+the+True+Believer%3A+A+Response&rft.au=Wertz%2C+Robert+T&rft.aulast=Wertz&rft.aufirst=Robert&rft.date=2003-06-01&rft.volume=11&rft.issue=2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Speech-Language+Pathology&rft.issn=10651438&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2005-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JSLPEP N1 - SubjectsTermNotLitGenreText - Speech Therapy (83200); Language Therapy (44400); Judgment (39900); Diagnosis (18540); Health Care Practitioners (31130); Research Design (72950); Videotape Recordings (94000) ER - TY - JOUR T1 - Semantic and Cross-Case Identity Priming in Patients with Parkinson's Disease AN - 85580776; 200312824 AB - Semantic & cross-case identity priming were investigated in nondemented patients with Parkinson's disease (PD) & controls using the Lexical Decision Task. Three conditions were administered that consisted of the presentation of prime & target word pairs. In the semantic priming condition the word pairs were semantically related (eg, table-CHAIR), in the cross-case identity priming condition the word pairs consisted of the same word (eg, noise-NOISE), & in the unrelated condition the word pairs were not related semantically (eg, guns-DEEP). A fourth condition was also administered that consisted of the presentation of a prime word & a pronounceable nonword target (eg, starved-FORVE). Participants were asked to indicate whether the target was a real word or a nonword. The prime & target were separated by either a short or long (250 ms or 1000 ms) stimulus onset asynchrony (SOA). Results indicated that PD patients displayed normal semantic priming (ie, faster responding to the target in the semantic condition as compared to the unrelated condition) at both the short & long SOA. Similarly, PD patients displayed normal cross-case identity priming (ie, faster responding to the target in the identity condition relative to the unrelated condition) at the long SOA. At the short SOA, however, PD patients displayed hyper identity priming relative to controls (134 ms vs. 50 ms). These results suggest that semantic processes are normal in nondemented PD patients but that the processes involved in accessing lexical information may be overly activated in these patients. 4 Tables, 1 Figure, 82 References. Adapted from the source document JF - Journal of Clinical and Experimental Neuropsychology AU - Filoteo, J Vincent AU - Friedrich, Frances J AU - Rilling, Laurie M AU - Davis, Jennifer D AU - Stricker, John L AU - Prenovitz, Mark AD - Psychology Service, Veterans Administration San Diego Healthcare System, CA vfiloteo@ucsd.edu Y1 - 2003/06// PY - 2003 DA - June 2003 SP - 441 EP - 456 VL - 25 IS - 4 SN - 1380-3395, 1380-3395 KW - Priming (67670) KW - Nonsense Words (58350) KW - Language Pathology (43250) KW - Lexical Access (46630) KW - Parkinsons Disease (62800) KW - Word Recognition (98200) KW - Semantic Processing (76760) KW - article KW - 4014: psycholinguistics; semantic processing KW - 6410: language-pathological and normal; language-pathological and normal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85580776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+and+Experimental+Neuropsychology&rft.atitle=Semantic+and+Cross-Case+Identity+Priming+in+Patients+with+Parkinson%27s+Disease&rft.au=Filoteo%2C+J+Vincent%3BFriedrich%2C+Frances+J%3BRilling%2C+Laurie+M%3BDavis%2C+Jennifer+D%3BStricker%2C+John+L%3BPrenovitz%2C+Mark&rft.aulast=Filoteo&rft.aufirst=J&rft.date=2003-06-01&rft.volume=25&rft.issue=4&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+and+Experimental+Neuropsychology&rft.issn=13803395&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCENE8 N1 - SubjectsTermNotLitGenreText - Parkinsons Disease (62800); Semantic Processing (76760); Language Pathology (43250); Lexical Access (46630); Priming (67670); Word Recognition (98200); Nonsense Words (58350) ER - TY - JOUR T1 - Apnea and seizures following retrobulbar local anesthetic injection. AN - 73504656; 12888161 AB - Surgery on the eye is performed using topical anesthesia, retrobulbar anesthesia, peribulbar anesthesia, and general anesthesia. Retrobulbar anesthesia is associated with a number of complications that include apnea (respiratory arrest), seizures, or both. Although these complications are transient and self-limiting, they can be life-threatening if not recognized and treated early. We report two patients who developed apnea, one of whom had cardiorespiratory arrest; and two other patients who presented with seizures. We provided ventilation with 100% oxygen, treated the hypertension with nicardipine, and the tachycardia with esmolol. The patients did not have any residual complications. JF - Journal of clinical anesthesia AU - Moorthy, Sreenivasa S AU - Zaffer, Rashid AU - Rodriguez, Sandra AU - Ksiazek, Susan AU - Yee, Robert D AD - Department of Anesthesia, Roudebush V.A. Medical Center, Indianapolis, IN 46202, USA. Screenivasa.Moorthy@med.va.gov Y1 - 2003/06// PY - 2003 DA - June 2003 SP - 267 EP - 270 VL - 15 IS - 4 SN - 0952-8180, 0952-8180 KW - Anesthetics, Local KW - 0 KW - Index Medicus KW - Aged, 80 and over KW - Ophthalmologic Surgical Procedures KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Seizures -- chemically induced KW - Anesthetics, Local -- administration & dosage KW - Apnea -- drug therapy KW - Anesthetics, Local -- adverse effects KW - Seizures -- drug therapy KW - Apnea -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73504656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+anesthesia&rft.atitle=Apnea+and+seizures+following+retrobulbar+local+anesthetic+injection.&rft.au=Moorthy%2C+Sreenivasa+S%3BZaffer%2C+Rashid%3BRodriguez%2C+Sandra%3BKsiazek%2C+Susan%3BYee%2C+Robert+D&rft.aulast=Moorthy&rft.aufirst=Sreenivasa&rft.date=2003-06-01&rft.volume=15&rft.issue=4&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+anesthesia&rft.issn=09528180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-05 N1 - Date created - 2003-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pilot study comparing motivational interviewing and an educational intervention in patients with schizophrenia and alcohol use disorders. AN - 73480753; 12836801 AB - Thirty subjects with comorbid schizophrenia and alcohol use disorders were randomly assigned to receive either a Motivational Interviewing (MI) or Educational Treatment (ET) intervention with treatment goals of abstinence and/or decreased alcohol use. Subjects were followed up at 4, 8 and 24-weeks upon completion of the interventions. Outcome measures included number of drinking days, abstinence rates, average blood alcohol concentration and standard ethanol content per drinking day. Subjects randomized to the MI intervention had a significant reduction in drinking days and an increase in abstinence rates when compared to subjects receiving ET. Motivational Interviewing may be a useful treatment intervention for individuals with schizophrenia and alcoholism. JF - Community mental health journal AU - Graeber, David A AU - Moyers, Theresa B AU - Griffith, Gayle AU - Guajardo, Eliseo AU - Tonigan, Scott AD - New Mexico VA Health Care System and the University of New Mexico Health Science Center, San Pedro SE, Albquerque 87108, USA. david.graeber@med.va.gov Y1 - 2003/06// PY - 2003 DA - June 2003 SP - 189 EP - 202 VL - 39 IS - 3 SN - 0010-3853, 0010-3853 KW - Index Medicus KW - Prospective Studies KW - Humans KW - Adult KW - Treatment Outcome KW - Diagnosis, Dual (Psychiatry) KW - Pilot Projects KW - Middle Aged KW - New Mexico KW - Mental Health Services KW - Male KW - Female KW - Comorbidity KW - Motivation KW - Alcoholism -- epidemiology KW - Directive Counseling KW - Alcoholism -- therapy KW - Schizophrenia -- therapy KW - Schizophrenia -- complications KW - Alcoholism -- complications KW - Psychotherapy, Brief UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73480753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+mental+health+journal&rft.atitle=A+pilot+study+comparing+motivational+interviewing+and+an+educational+intervention+in+patients+with+schizophrenia+and+alcohol+use+disorders.&rft.au=Graeber%2C+David+A%3BMoyers%2C+Theresa+B%3BGriffith%2C+Gayle%3BGuajardo%2C+Eliseo%3BTonigan%2C+Scott&rft.aulast=Graeber&rft.aufirst=David&rft.date=2003-06-01&rft.volume=39&rft.issue=3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Community+mental+health+journal&rft.issn=00103853&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-10-07 N1 - Date created - 2003-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neoral-to-Gengraf conversion in renal transplant recipients. AN - 73421069; 12826145 AB - Our objective was to evaluate the safety, efficacy, and need for dosage adjustments when patients taking the Neoral formulation of cyclosporine are converted to the generic formulation, Gengraf. From September 2001 through January 2002, patients receiving follow-up care in the renal transplant clinic at the VA Tennessee Valley Healthcare System were converted from Neoral to Gengraf based on a 1:1 dosing equivalency. Steady-state cyclosporine trough concentrations were obtained both prior to and following Neoral-to-Gengraf conversions. Patients were also monitored for changes in serum creatinine, hospitalization, cyclosporine toxicity, graft rejection, and need for further adjustment in cyclosporine regimen. Forty-one patients were included in data analysis. There were no differences in cyclosporine concentrations (P =.0853) or serum creatinine (P =.4469) following conversion to Gengraf. There were no reports of cyclosporine toxicity, no episodes of graft rejection, and no need for further dose adjustment related to the generic conversion. Neoral and Gengraf are therapeutically equivalent cyclosporine formulations, such that renal transplant recipients maintained on Neoral can be safely and effectively converted to the Gengraf formulation based on a 1:1 conversion ratio. The use of Gengraf over Neoral within the Veterans Affairs Healthcare System offers a reduced cost alternative but maintains equal efficacy and outcomes. JF - Transplantation proceedings AU - Carnahan, W AU - Cooper, T Y AD - VA Tennessee Valley Healthcare System, Nashville, Tennessee 37212, USA. lewiscarnahan2@med.va.gov Y1 - 2003/06// PY - 2003 DA - June 2003 SP - 1308 EP - 1313 VL - 35 IS - 4 SN - 0041-1345, 0041-1345 KW - Immunosuppressive Agents KW - 0 KW - Cyclosporine KW - 83HN0GTJ6D KW - Creatinine KW - AYI8EX34EU KW - Index Medicus KW - Tissue Donors -- statistics & numerical data KW - Humans KW - Adult KW - Tennessee KW - Aged KW - Middle Aged KW - Creatinine -- blood KW - Male KW - Female KW - Chemistry, Pharmaceutical KW - Cyclosporine -- therapeutic use KW - Kidney Transplantation -- immunology KW - Immunosuppressive Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73421069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transplantation+proceedings&rft.atitle=Neoral-to-Gengraf+conversion+in+renal+transplant+recipients.&rft.au=Carnahan%2C+W%3BCooper%2C+T+Y&rft.aulast=Carnahan&rft.aufirst=W&rft.date=2003-06-01&rft.volume=35&rft.issue=4&rft.spage=1308&rft.isbn=&rft.btitle=&rft.title=Transplantation+proceedings&rft.issn=00411345&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-11 N1 - Date created - 2003-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol abuse and dependence: psychopathology, medical management and dental implications. AN - 73420706; 12839410 AB - The authors review the clinical features, epidemiology, pathophysiology, medical management, dental findings and dental treatment of patients with alcoholism. The authors conducted a MEDLINE search for 1995 through 2001 using the key terms of alcoholism, epidemiology, pathophysiology, treatment and dentistry. Reports selected for further review included those published in English in peer-reviewed journals. The authors gave preference to articles reporting randomized, controlled trials. Alcoholism is a chronic and progressive psychiatric illness that afflicts more than 14 million Americans. It is characterized by a loss of control over the use of alcohol, resulting in impaired social functioning, and the consequent development of medical illnesses. The disease arises in genetically vulnerable people when they are overwhelmed by their cravings for the alcohol-associated euphoria that results from the actions of several neurotransmitter systems in the brain's pleasure center. New medications to counteract alcohol-induced neurotransmission imbalance may assist patients in reducing their craving. The prevalence of dental disease usually is extensive because of a disinterest in performing appropriate oral hygiene techniques and diminished salivary flow. Concurrent abuse of tobacco products worsens dental disease and heightens the risk of developing oral cancer. Identification of the alcohol-abusing patient, a cancer-screening examination, preventive dental education, and use of saliva substitutes and anticaries agents are indicated. Special precautions must be taken when performing surgery and when prescribing or administering analgesics, antibiotics or sedative agents that are likely to have an adverse interaction with alcohol or psychiatric medications. JF - Journal of the American Dental Association (1939) AU - Friedlander, Arthur H AU - Marder, Stephen R AU - Pisegna, Joseph R AU - Yagiela, John A AD - VA Greater Los Angeles Healthcare System, Calif. 90073, USA. arthur.friedlander@med.va.gov Y1 - 2003/06// PY - 2003 DA - June 2003 SP - 731 EP - 740 VL - 134 IS - 6 SN - 0002-8177, 0002-8177 KW - Alcohol Deterrents KW - 0 KW - Ethanol KW - 3K9958V90M KW - Dentistry KW - Index Medicus KW - Alcohol Deterrents -- adverse effects KW - Nutrition Disorders -- chemically induced KW - Drug Interactions KW - Sialorrhea -- chemically induced KW - Humans KW - Smoking -- adverse effects KW - Sialorrhea -- complications KW - Mouth Neoplasms -- complications KW - Nutrition Disorders -- complications KW - Hemorrhage -- etiology KW - Mandibular Fractures -- complications KW - Xerostomia -- complications KW - Ethanol -- adverse effects KW - Xerostomia -- chemically induced KW - Tobacco Use Disorder -- complications KW - Alcohol-Related Disorders -- complications KW - Periodontal Diseases -- etiology KW - Alcohol-Related Disorders -- therapy KW - Liver Diseases, Alcoholic -- complications KW - Dental Care for Chronically Ill UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73420706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Alcohol+abuse+and+dependence%3A+psychopathology%2C+medical+management+and+dental+implications.&rft.au=Friedlander%2C+Arthur+H%3BMarder%2C+Stephen+R%3BPisegna%2C+Joseph+R%3BYagiela%2C+John+A&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2003-06-01&rft.volume=134&rft.issue=6&rft.spage=731&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-09-26 N1 - Date created - 2003-07-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Am Dent Assoc. 2003 Oct;134(10):1306; author reply 1306 [14620002] J Am Dent Assoc. 2003 Oct;134(10):1306, 1308; author reply 1308 [14620003] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Imipramine-associated hyperpigmentation. AN - 73331754; 12773071 AB - To inform clinicians of the potential for severe and persistent facial hyperpigmentation with the long-term use of imipramine. A 65-year-old white male veteran with a history of paranoid schizophrenia was referred to the psychiatry service by a dentist who thought that the patient was both cyanotic and psychotic. The history and biopsy results indicated the possibility of imipramine-associated hyperpigmentation, only the second reported case in a male patient. The presentation was complex, with a history of neuroleptic exposure and multiple signs of parkinsonism. A brain single photon-emission computed tomography scan demonstrated frontal lobe hypermetabolism and bilateral caudate hypermetabolism, which normalized 14 months later. Despite discontinuation of imipramine, the patient continued to appear cyanotic, leading to worsening social isolation. He became known as "the man with the purple face." On his rare ventures outside the home, he was embarrassed by sporadic calls to 911 by persons fearing he was ill. Although facial hyperpigmentation secondary to the use of phenothiazines has been reported frequently, it is much less common with imipramine, and is very rare in males. Failure to recognize this adverse reaction led to continuing treatment with imipramine and to an apparently irreversible condition. The brain imaging findings have no link with the hyperpigmenting process, but raise questions about neuroleptic-induced metabolic changes in the brain. Clinicians need to be aware of rare adverse reactions such as hyperpigmentation, and be prepared to take appropriate and early action to prevent such reactions from becoming irreversible. JF - The Annals of pharmacotherapy AU - Dean, Charles E AU - Grund, Frank M AD - Tardive Dyskinesia Clinic, Minneapolis Veterans Affairs Medical Center and School of Medicine, University of Minnesota, Minneapolis, MN 55417-2309, USA. charles.dean@med.va.gov Y1 - 2003/06// PY - 2003 DA - June 2003 SP - 825 EP - 828 VL - 37 IS - 6 SN - 1060-0280, 1060-0280 KW - Imipramine KW - OGG85SX4E4 KW - Index Medicus KW - Humans KW - Aged KW - Male KW - Imipramine -- adverse effects KW - Hyperpigmentation -- physiopathology KW - Hyperpigmentation -- diagnosis KW - Hyperpigmentation -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73331754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Imipramine-associated+hyperpigmentation.&rft.au=Dean%2C+Charles+E%3BGrund%2C+Frank+M&rft.aulast=Dean&rft.aufirst=Charles&rft.date=2003-06-01&rft.volume=37&rft.issue=6&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-01 N1 - Date created - 2003-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gabapentin for the treatment of ethanol withdrawal. AN - 73330048; 12766380 AB - Benzodiazepines (BZDs) are the drug of choice for the suppression of alcohol withdrawal symptoms. Gabapentin, a drug approved for use as adjunctive therapy in the treatment of partial seizures, has none of the BZD-type difficulties (drug interactions, abuse potential). We retrospectively report on the use of gabapentin for ethanol withdrawal in 49 patients. Thirty-one patients were treated in the outpatient program and 18 in the general inpatient psychiatric unit. Positive outcomes as evidenced by completion of gabapentin therapy were achieved in 25 out of 31 outpatients and 17 out of 18 inpatients. Statistical significance was reached regarding the positive relationship between prior ethanol use and inpatient "as needed" benzodiazepine use. Both sets of data suggest that gabapentin works well for the mild to moderate alcohol withdrawal patient. JF - Substance abuse AU - Voris, John AU - Smith, Nancy L AU - Rao, Subba M AU - Thorne, Diana L AU - Flowers, Queen J AD - Mental Health Service Line, WJBD Veteran's Affairs Medical Center, Columbia, South Carolina 29209, USA. John.Voris@med.va.gov Y1 - 2003/06// PY - 2003 DA - June 2003 SP - 129 EP - 132 VL - 24 IS - 2 SN - 0889-7077, 0889-7077 KW - Acetates KW - 0 KW - Amines KW - Anticonvulsants KW - Central Nervous System Depressants KW - Cyclohexanecarboxylic Acids KW - Benzodiazepines KW - 12794-10-4 KW - Ethanol KW - 3K9958V90M KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - gabapentin KW - 6CW7F3G59X KW - Index Medicus KW - Benzodiazepines -- therapeutic use KW - Humans KW - Adult KW - Retrospective Studies KW - Alcohol Withdrawal Seizures -- drug therapy KW - Middle Aged KW - Male KW - Female KW - Ethanol -- adverse effects KW - Central Nervous System Depressants -- adverse effects KW - Substance-Related Disorders -- drug therapy KW - Acetates -- therapeutic use KW - Substance Withdrawal Syndrome -- drug therapy KW - Anticonvulsants -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73330048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+abuse&rft.atitle=Gabapentin+for+the+treatment+of+ethanol+withdrawal.&rft.au=Voris%2C+John%3BSmith%2C+Nancy+L%3BRao%2C+Subba+M%3BThorne%2C+Diana+L%3BFlowers%2C+Queen+J&rft.aulast=Voris&rft.aufirst=John&rft.date=2003-06-01&rft.volume=24&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Substance+abuse&rft.issn=08897077&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-20 N1 - Date created - 2003-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - "Do-It-Yourself" Dementia Testing: Issues regarding an Alzheimer's Home Screening Test AN - 61330862; 200400120 AB - The Early Alert Alzheimer's Home Screening Test (AHST) is a variant of the Smell Identification Test (SIT) & the Cross-Cultural Smell Identification Test (CC-SIT), & recently became available for purchase by the general public. The validity & the practical utility of routine screening for individuals with asymptomatic cognitive impairment has not been established. There are considerable specific methodological concerns regarding the use of the AHST including the association of olfactory impairment with (1) age in the absence of cognitive impairment, (2) numerous acute &/or chronic medical conditions, & (3) lifestyle habits & social &/or demographic variables. General public misunderstanding of the difference between a screening & a diagnostic test, primary care physicians' frequent confusion about follow-up mechanisms for newly diagnosed patients with dementia, the possible lack of perceived counseling options for those self-diagnosed, & abuse of test findings create distinct possibilities for misuse of this test. The marketing of the AHST & its general use without appropriate public health educational safeguards is inappropriate & may be unethical. 50 References. Adapted from the source document. JF - The Gerontologist AU - Kier, Frederick J AU - Molinari, Victor AD - Highland Drive Division, VA Pittsburgh Healthcare System, PA frederick.kier@med.va.gov Y1 - 2003/06// PY - 2003 DA - June 2003 SP - 295 EP - 301 VL - 43 IS - 3 SN - 0016-9013, 0016-9013 KW - Diagnosis KW - Alzheimer's Disease KW - Cognitive Functioning KW - Methodological Problems KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61330862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Gerontologist&rft.atitle=%22Do-It-Yourself%22+Dementia+Testing%3A+Issues+regarding+an+Alzheimer%27s+Home+Screening+Test&rft.au=Kier%2C+Frederick+J%3BMolinari%2C+Victor&rft.aulast=Kier&rft.aufirst=Frederick&rft.date=2003-06-01&rft.volume=43&rft.issue=3&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=The+Gerontologist&rft.issn=00169013&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-10-30 N1 - Number of references - 50 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Alzheimer's Disease; Diagnosis; Cognitive Functioning; Methodological Problems ER - TY - JOUR T1 - Promoting Quality of Life for Clients Diagnosed with Dementia AN - 21226320; 11613559 AB - Much of the nursing research related to clients diagnosed with dementia has focused on management of disruptive behaviors, safety, and basic sustenance with little attention to the higher level developmental needs of love, belonging, self-esteem, self-actualization, and aesthetics. As nurses seek to understand the links between cognitive, functional, and developmental decline and focus interventions on meeting the higher level needs of their clients, they can provide more comprehensive care and promote quality of life for clients diagnosed with dementia. JF - Journal of the American Psychiatric Nurses Association AU - Hendry, Karen C AU - Douglas, Dianna H AD - Veterans Administration, Gulfport, Mississippi Y1 - 2003/06// PY - 2003 DA - Jun 2003 SP - 96 EP - 102 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 9 IS - 3 SN - 1078-3903, 1078-3903 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21226320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Psychiatric+Nurses+Association&rft.atitle=Promoting+Quality+of+Life+for+Clients+Diagnosed+with+Dementia&rft.au=Hendry%2C+Karen+C%3BDouglas%2C+Dianna+H&rft.aulast=Hendry&rft.aufirst=Karen&rft.date=2003-06-01&rft.volume=9&rft.issue=3&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Psychiatric+Nurses+Association&rft.issn=10783903&rft_id=info:doi/10.1016%2FS1078-3903%2803%2900109-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1016/S1078-3903(03)00109-5 ER - TY - JOUR T1 - Lactobacillus paracasei Continuous Ambulatory Peritoneal Dialysis-Related Peritonitis and Review of the Literature AN - 18810181; 5684700 AB - We describe the first case of continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis due to Lactobacillus paracasei. It occurred in a 65-year-old patient with recurrent episodes of peritonitis while he was receiving a prolonged course of intraperitoneal vancomycin. L. paracasei should be considered in the differential diagnosis of pathogens in CAPD-related peritonitis, especially in patients receiving prolonged vancomycin or glycopeptide treatment. JF - Journal of Clinical Microbiology AU - Neef, P A AU - Polenakovik, H AU - Clarridge, JE AU - Saklayen, M AU - Bogard, L AU - Bernstein, J M AD - VAMC (111W), 4100 W. Third St., Dayton, OH 45428, Hari.polenakovik@med.va.gov Y1 - 2003/06// PY - 2003 DA - Jun 2003 SP - 2783 EP - 2784 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 41 IS - 6 SN - 0095-1137, 0095-1137 KW - continuous ambulatory peritoneal dialysis KW - Microbiology Abstracts B: Bacteriology KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18810181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Lactobacillus+paracasei+Continuous+Ambulatory+Peritoneal+Dialysis-Related+Peritonitis+and+Review+of+the+Literature&rft.au=Neef%2C+P+A%3BPolenakovik%2C+H%3BClarridge%2C+JE%3BSaklayen%2C+M%3BBogard%2C+L%3BBernstein%2C+J+M&rft.aulast=Neef&rft.aufirst=P&rft.date=2003-06-01&rft.volume=41&rft.issue=6&rft.spage=2783&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.41.6.2783-2784.2003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1128/JCM.41.6.2783-2784.2003 ER - TY - JOUR T1 - In vivo bone formation in fracture repair induced by direct retroviral-based gene therapy with bone morphogenetic protein-4 AN - 18806826; 5681835 AB - This study sought to develop an in vivo gene therapy to accelerate the repair of bone fractures. In vivo administration of an engineered viral vector to promote fracture healing represents a potential high-efficacy, low-risk procedure. We selected a murine leukemia virus (MLV)-based retroviral vector, because this vector would be expected to target transgene expression to the proliferating periosteal cells arising shortly after bone fracture. This vector transduced a hybrid gene that consisted of a bone morphogenetic protein (BMP)-4 transgene with the BMP-2 secretory signal to enhance the secretion of mature BMP-4. The MLV vector expressing this BMP-2/4 hybrid gene or beta -galactosidase control gene was administered at the lateral side of the fracture periosteum at 1 day after fracture in the rat femoral fracture model. X-ray examination by radiograph and peripheral quantitative computed tomography at 7, 14, and 28 days after fracture revealed a highly significant enhancement of fracture tissue size in the MLV-BMP-2 /4-treated fractures compared to the control fractures. The tissue was extensively ossified at 14 and 28 days, and the newly formed bone exhibited normal bone histology. This tissue also exhibited strong immunohistochemical staining of BMP-4. Additional control and MLV-BMP-2/4-treated animals each were monitored for 70 days to determine the fate of the markedly enhanced fracture callus. Radiographs showed that the hard callus had been remodeled and substantial healing at the fracture site had occurred, suggesting that the union of the bone at the fracture site was at least as high in the BMP-4-treated bone as in the control bone. There was no evidence of viral vector infection of extraskeletal tissues, suggesting that this in vivo gene therapy for fracture repair is safe. In summary, we have demonstrated for the first time that a MLV-based retroviral vector is a safe and effective means of introducing a transgene to a fracture site and that this procedure caused an enormous augmentation of fracture bone formation. JF - Bone AU - Rundle, CH AU - Miyakoshi, N AU - Kasukawa, Y AU - Chen, S AU - Sheng, M H AU - Wergedal, JE AU - Lau, K W AU - Baylink, D J AD - Departments of Medicine and Biochemistry, Loma Linda University and the Musculoskeletal Disease Center (151), Jerry L. Pettis Memorial Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA, David.Baylink@med.va.gov Y1 - 2003/06// PY - 2003 DA - Jun 2003 SP - 591 EP - 601 PB - Elsevier Science (USA) VL - 32 IS - 6 SN - 8756-3282, 8756-3282 KW - rats KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - T 20031:Fractures and bone healing KW - W 30965:Miscellaneous, Reviews KW - W4 120:Genetic Engineering in Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18806826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bone&rft.atitle=In+vivo+bone+formation+in+fracture+repair+induced+by+direct+retroviral-based+gene+therapy+with+bone+morphogenetic+protein-4&rft.au=Rundle%2C+CH%3BMiyakoshi%2C+N%3BKasukawa%2C+Y%3BChen%2C+S%3BSheng%2C+M+H%3BWergedal%2C+JE%3BLau%2C+K+W%3BBaylink%2C+D+J&rft.aulast=Rundle&rft.aufirst=CH&rft.date=2003-06-01&rft.volume=32&rft.issue=6&rft.spage=591&rft.isbn=&rft.btitle=&rft.title=Bone&rft.issn=87563282&rft_id=info:doi/10.1016%2FS8756-3282%2803%2900096-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1016/S8756-3282(03)00096-6 ER - TY - JOUR T1 - Bacterial invasion by a paracellular route: divide and conquer AN - 18766635; 5638372 AB - The epithelium of the host plays an important first line of defense against most human pathogens. Microbial factors have been identified that are involved in the destruction of the structures that maintain the integrity of the epithelium. The mechanisms used by several, selected bacteria for the disruption of epithelial cell-cell junctions are discussed. JF - Microbes and Infection AU - Balkovetz, D F AU - Katz, J AD - Departments of Medicine, Cell Biology, and Microbiology, University of Alabama at Birmingham and Veterans Administration Medical Center, Birmingham AL 35294, USA, balkovet@uab.edu Y1 - 2003/06// PY - 2003 DA - Jun 2003 SP - 613 EP - 619 VL - 5 IS - 7 SN - 1286-4579, 1286-4579 KW - man KW - Microbiology Abstracts B: Bacteriology KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18766635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbes+and+Infection&rft.atitle=Bacterial+invasion+by+a+paracellular+route%3A+divide+and+conquer&rft.au=Balkovetz%2C+D+F%3BKatz%2C+J&rft.aulast=Balkovetz&rft.aufirst=D&rft.date=2003-06-01&rft.volume=5&rft.issue=7&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=Microbes+and+Infection&rft.issn=12864579&rft_id=info:doi/10.1016%2FS1286-4579%2803%2900089-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1016/S1286-4579(03)00089-3 ER - TY - JOUR T1 - Transporting efficacious treatments from academia to community: barriers and opportunities. AN - 73242049; 12732404 JF - Drug and alcohol dependence AU - Saxon, Andrew J AD - Department of Psychiatry and Behavioral Sciences, Center of Excellence in Substance Abuse Treatment and Education, University of Washington, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle 98108-1595, USA. andrew.saxon@med.va.gov Y1 - 2003/05/21/ PY - 2003 DA - 2003 May 21 SP - 127 EP - 129 VL - 70 IS - 2 SN - 0376-8716, 0376-8716 KW - Index Medicus KW - Humans KW - Substance-Related Disorders -- therapy KW - Community Health Services -- methods KW - Academic Medical Centers -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73242049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Transporting+efficacious+treatments+from+academia+to+community%3A+barriers+and+opportunities.&rft.au=Saxon%2C+Andrew+J&rft.aulast=Saxon&rft.aufirst=Andrew&rft.date=2003-05-21&rft.volume=70&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-10-15 N1 - Date created - 2003-05-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Drug Alcohol Depend. 2003 May 21;70(2):117-25 [12732403] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The cost-effectiveness of cyclooxygenase-2 selective inhibitors in the management of chronic arthritis. AN - 73268140; 12755551 AB - Rofecoxib and celecoxib (coxibs) effectively treat chronic arthritis pain and reduce ulcer complications by 50% compared with nonselective nonsteroidal anti-inflammatory drugs (NSAIDs). However, their absolute risk reduction is small and the cost-effectiveness of treatment is uncertain. To determine whether the degree of risk reduction in gastrointestinal complications by coxibs offsets their increased cost compared with a generic nonselective NSAID. Cost-utility analysis. Systematic review of MEDLINE and published abstracts. Patients with osteoarthritis or rheumatoid arthritis who are not taking aspirin and who require long-term NSAID therapy for moderate to severe arthritis pain. Third-party payer. Naproxen, 500 mg twice daily, and coxib, once daily. Patients intolerant of naproxen were switched to a coxib. Lifetime. Incremental cost per quality-adjusted life-year (QALY) gained. Using a coxib instead of a nonselective NSAID in average-risk patients cost an incremental 275 809 dollars per year to gain 1 additional QALY. The incremental cost per QALY gained decreased to 55 803 dollars when the analysis was limited to the subset of patients with a history of bleeding ulcers. The coxib strategy became dominant when the cost of coxibs was reduced by 90% of the current average wholesale price. In probabilistic sensitivity analysis, if a third-party payer was willing to pay 150 000 dollars per QALY gained, then 4.3% of average-risk patients would fall within the budget. The risk reduction seen with coxibs does not offset their increased costs compared with nonselective NSAIDs in the management of average-risk patients with chronic arthritis. However, coxibs may provide an acceptable incremental cost-effectiveness ratio in the subgroup of patients with a history of bleeding ulcers. JF - Annals of internal medicine AU - Spiegel, Brennan M R AU - Targownik, Laura AU - Dulai, Gareth S AU - Gralnek, Ian M AD - Veterans Administration Greater Los Angeles Healthcare System, David Geffen School of Medicine at University of California, CURE Digestive Diseases Research Center, Los Angeles, CA 90073, USA. Y1 - 2003/05/20/ PY - 2003 DA - 2003 May 20 SP - 795 EP - 806 VL - 138 IS - 10 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase 2 Inhibitors KW - Cyclooxygenase Inhibitors KW - Isoenzymes KW - Lactones KW - Membrane Proteins KW - Pyrazoles KW - Sulfonamides KW - Sulfones KW - rofecoxib KW - 0QTW8Z7MCR KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Celecoxib KW - JCX84Q7J1L KW - Abridged Index Medicus KW - Index Medicus KW - Sensitivity and Specificity KW - Humans KW - Peptic Ulcer -- prevention & control KW - Cardiovascular Diseases -- chemically induced KW - Peptic Ulcer -- chemically induced KW - Recurrence KW - Quality-Adjusted Life Years KW - Risk Factors KW - Cost-Benefit Analysis KW - Chronic Disease KW - Decision Support Techniques KW - Arthritis, Rheumatoid -- drug therapy KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- economics KW - Lactones -- economics KW - Cyclooxygenase Inhibitors -- economics KW - Sulfonamides -- therapeutic use KW - Cyclooxygenase Inhibitors -- adverse effects KW - Cyclooxygenase Inhibitors -- therapeutic use KW - Isoenzymes -- antagonists & inhibitors KW - Lactones -- adverse effects KW - Sulfonamides -- adverse effects KW - Lactones -- therapeutic use KW - Sulfonamides -- economics KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Osteoarthritis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73268140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=The+cost-effectiveness+of+cyclooxygenase-2+selective+inhibitors+in+the+management+of+chronic+arthritis.&rft.au=Spiegel%2C+Brennan+M+R%3BTargownik%2C+Laura%3BDulai%2C+Gareth+S%3BGralnek%2C+Ian+M&rft.aulast=Spiegel&rft.aufirst=Brennan+M&rft.date=2003-05-20&rft.volume=138&rft.issue=10&rft.spage=795&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-06-05 N1 - Date created - 2003-05-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Intern Med. 2004 May 4;140(9):761; author reply 761-2 [15126263] ACP J Club. 2003 Sep-Oct;139(2):53 [12954045] Summary For Patients In: Ann Intern Med. 2003 May 20;138(10):I39 [12755582] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tc-99m depreotide SPECT demonstrates photon-deficiency in the thoracic vertebrae after adjunct radiation therapy of lung cancer: Correlation with MRI and bone scintigraphy AN - 904463468; 13922129 AB - Fifteen months after right lobe lobectomy with adjunctive radiation therapy for squamous cell carcinoma, a patient 53-yr-old man underwent Tc-99m depreotide chest single photon emission tomography (SPECT). In addition to two focal areas of abnormally increased uptake in the right lung, the Tc-99m depreotide SPECT showed cold areas in the middle thoracic vertebrae. Photopenic areas in the 6th and 7th thoracic vertebrae were shown on a bone scintigraphy. T1 weighted magnetic resonance imaging (MRI) of the spine showed fatty replacement of the marrow and Schmorl's nodes involving the 5th to 11th thoracic vertebrae. The vertebrae are normally visualized in Tc-99m depreotide SPECT imaging study, and lung tumor is usually somatostatin receptor positive with demonstrable activity in the lung. Absent uptake in the vertebrae in the fatty replacement of the marrow and multiple and giant vertebral Schmorl's nodes in the correspondent vertebrae in MRI may reflect visualization of vertebrae due to Tc-99m depreotide localizing in the bone marrow. Of the three imaging modalities, MRI showed the widest areas of thoracic vertebral involvement. One should be aware that a cold lesion in the vertebrae on Tc-99m depreotide imaging study may result from irradiation and may indicate the presence of a benign lesion in the bone marrow. JF - Annals of Nuclear Medicine AU - Shih, Wei-Jen AU - Wyk, Charl AD - Nuclear Medicine Service, Lexington VA Medical Center, 1101 Veterans Dr., 40502, Lexington, KY, USA, wei-jen.shih@med.va.gov Y1 - 2003/05// PY - 2003 DA - May 2003 SP - 245 EP - 248 PB - Springer Japan KK, Tokyo VL - 17 IS - 3 SN - 0914-7187, 0914-7187 KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Bone cancer KW - Somatostatin receptors KW - Magnetic resonance imaging KW - Bone marrow KW - squamous cell carcinoma KW - Tumors KW - Chest KW - Scintigraphy KW - Vertebrae KW - Single photon emission computed tomography KW - Spine KW - Radiation KW - Thorax KW - Nuclear medicine KW - Nodes KW - Lung cancer KW - Benign KW - W 30910:Imaging KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904463468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Nuclear+Medicine&rft.atitle=Tc-99m+depreotide+SPECT+demonstrates+photon-deficiency+in+the+thoracic+vertebrae+after+adjunct+radiation+therapy+of+lung+cancer%3A+Correlation+with+MRI+and+bone+scintigraphy&rft.au=Shih%2C+Wei-Jen%3BWyk%2C+Charl&rft.aulast=Shih&rft.aufirst=Wei-Jen&rft.date=2003-05-01&rft.volume=17&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Annals+of+Nuclear+Medicine&rft.issn=09147187&rft_id=info:doi/10.1007%2FBF02990029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Bone cancer; Somatostatin receptors; Magnetic resonance imaging; Bone marrow; squamous cell carcinoma; Tumors; Chest; Scintigraphy; Vertebrae; Single photon emission computed tomography; Spine; Radiation; Thorax; Nuclear medicine; Nodes; Benign; Lung cancer DO - http://dx.doi.org/10.1007/BF02990029 ER - TY - JOUR T1 - The Inter-Rater Reliability of the Story Retell Procedure AN - 85579927; 200308838 AB - McNeil, Doyle, Fossett, Park, & Goda (2001) have presented the story retell procedure (SRP) as an efficient means of assessing discourse in adults with aphasia, in part because it provides reliable, valid, & sensitive indices of performance without the need for time-consuming transcription of language samples. The purpose of this study was to demonstrate that the SRP, when scored without transcription by judges with minimal training, produces a reliable measure of information transfer. Four judges who had not used the SRP previously scored audio-recorded language samples, produced by four subjects with aphasia & 11 normal subjects, for percent information units per minute (%IU/Min). The results demonstrate that the SRP has high inter-rater reliability. Reliability coefficients ranged from .89 to .995, & the standard error of measurement associated with inter-rater scoring error ranged from .59 to 1.42 %IU/Min. Point-to-point reliability in scoring individual information units ranged from 85-95% & averaged 91% for both subject groups. The SRP is a potentially useful tool for quantifying connected language behavior & may be particularly valuable in clinical & research settings where economy of assessment procedures is essential. 3 Tables, 19 References. Adapted from the source document JF - Aphasiology AU - Hula, William D AU - McNeil, Malcolm R AU - Doyle, Patrick J AU - Rubinsky, Hillel J AU - Fossett, Tepanta R D AD - Audiology & Speech Pathology, VA Pittsburgh Healthcare System, PA william.hula@med.va.gov Y1 - 2003/05// PY - 2003 DA - May 2003 SP - 523 EP - 528 VL - 17 IS - 5 SN - 0268-7038, 0268-7038 KW - Transfer (Learning) (90850) KW - Aphasia (03400) KW - Phonetic Transcription (64700) KW - Adults (00600) KW - Communicative Competence (13650) KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85579927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=The+Inter-Rater+Reliability+of+the+Story+Retell+Procedure&rft.au=Hula%2C+William+D%3BMcNeil%2C+Malcolm+R%3BDoyle%2C+Patrick+J%3BRubinsky%2C+Hillel+J%3BFossett%2C+Tepanta+R+D&rft.aulast=Hula&rft.aufirst=William&rft.date=2003-05-01&rft.volume=17&rft.issue=5&rft.spage=523&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Adults (00600); Communicative Competence (13650); Phonetic Transcription (64700); Transfer (Learning) (90850) ER - TY - JOUR T1 - Tracheal stomal recurrence of tonsillar cancer. AN - 85366110; pmid-12748578 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery AU - Moorthy, Sreenivasa S AU - Radpour, Shokri AD - Department of Anesthesia, Roudebush VA Medical Center, Indianapolis, IN 46202, USA. sreenivasa.moorthy@med.va.gov Y1 - 2003/05// PY - 2003 DA - May 2003 SP - 769 EP - 770 VL - 128 IS - 5 SN - 0194-5998, 0194-5998 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - *Carcinoma, Squamous Cell: pathology KW - Carcinoma, Squamous Cell: surgery KW - Combined Modality Therapy KW - Humans KW - Male KW - *Neoplasm Recurrence, Local KW - Surgical Stomas: adverse effects KW - *Surgical Stomas: pathology KW - *Tonsillar Neoplasms: pathology KW - Tonsillar Neoplasms: surgery KW - Tonsillectomy KW - *Tracheostomy: adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85366110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=Tracheal+stomal+recurrence+of+tonsillar+cancer.&rft.au=Moorthy%2C+Sreenivasa+S%3BRadpour%2C+Shokri&rft.aulast=Moorthy&rft.aufirst=Sreenivasa&rft.date=2003-05-01&rft.volume=128&rft.issue=5&rft.spage=769&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - A ten-year follow-up of older former problem drinkers: risk of relapse and implications of successfully sustained remission. AN - 73403235; 12817825 AB - This study examines the risk, predictors of relapse and the effects of successfully sustained remission on the drinking behavior, functioning, life context, coping and help seeking of older adults who were problem drinkers earlier in life. Older former problem drinkers (n = 447) were prospectively followed for 10 years and compared to lifetime nonproblem drinkers. Of former problem drinkers, 31% (n = 141) died over the 10-year interval, a rate 1.6 times higher than that of lifetime nonproblem drinkers. Among surviving former problem drinkers, although relapse was relatively uncommon (11%), a less severe drinking history, heavier baseline alcohol consumption, and lower baseline income were associated with relapse. The majority (63%) of former problem drinkers who successfully achieved sustained remission continued to drink alcohol, though at levels below those consumed by older lifetime nonproblem drinkers (n = 339). Stably remitted problem drinkers who were abstinent (SRAs) generally reported more severe drinking histories, greater functioning and life context deficits and more help seeking than did stably remitted problem drinkers who were nonabstinent (SRNs). Although SRAs and SRNs both experienced improvements in functioning over the 10-year interval, they continued to experience financial, health-related and life context deficits relative to older lifetime nonproblem drinkers. Results suggest there are long-term costs associated with earlier drinking problems, even when remission is maintained. Both current drinking behavior and drinking history are worth considering when making recommendations regarding older adults' alcohol consumption. JF - Journal of studies on alcohol AU - Schutte, K K AU - Nichols, K A AU - Brennan, P L AU - Moos, R H AD - Center for Health Care Evaluation, Department of Veterans Affairs Health Care System & Stanford University Medical Center, Menlo Park California 94025, USA. Kathleen.Schutte@med.va.gov Y1 - 2003/05// PY - 2003 DA - May 2003 SP - 367 EP - 374 VL - 64 IS - 3 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Analysis of Variance KW - Prospective Studies KW - Logistic Models KW - Risk Factors KW - Humans KW - Chi-Square Distribution KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Secondary Prevention KW - Male KW - Female KW - Alcoholism -- epidemiology KW - Temperance -- psychology KW - Alcohol Drinking -- psychology KW - Alcohol Drinking -- prevention & control KW - Alcohol Drinking -- epidemiology KW - Temperance -- statistics & numerical data KW - Alcoholism -- psychology KW - Alcoholism -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73403235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=A+ten-year+follow-up+of+older+former+problem+drinkers%3A+risk+of+relapse+and+implications+of+successfully+sustained+remission.&rft.au=Schutte%2C+K+K%3BNichols%2C+K+A%3BBrennan%2C+P+L%3BMoos%2C+R+H&rft.aulast=Schutte&rft.aufirst=K&rft.date=2003-05-01&rft.volume=64&rft.issue=3&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-10-17 N1 - Date created - 2003-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Safety issues in pharmacotherapy for smoking in patients with cardiovascular disease. AN - 73376592; 12800126 AB - Twenty percent of patients with cardiovascular disease smoke, and smoking cessation results in a dramatic decline in the relative risk of future cardiovascular events. Questions regarding the safety of nicotine-replacement therapy and bupropion SR for smoking cessation in patients with cardiovascular disease have arisen, in particular because of potential hemodynamic effects of these agents. There have been several randomized, controlled, clinical trials testing the safety of transdermal nicotine in patients with cardiovascular disease that failed to show an increased risk for cardiac events in active treatment conditions compared with placebo. Efficacy trials conducted in other patient populations also support the safety of nicotine-replacement use in cardiac disease patients. To date there is one randomized controlled trial to test bupropion for smoking cessation conducted in this population. Studies to test the efficacy of bupropion for smoking cessation and depression suggest it is safe to use in cardiac disease patients despite recent case reports of adverse events associated with bupropion use. Nicotine-replacement therapy and bupropion significantly increase long-term smoking cessation rates, and the benefits of cessation exceed the risks for pharmacotherapy in patients with cardiovascular disease. Copyright 2003, Elsevier Science (USA). All rights reserved. JF - Progress in cardiovascular diseases AU - Joseph, Anne M AU - Fu, Steven S AD - Department of Medicine, Veterans Affairs Health Services Research and Development Center of Excellence for Chronic Disease Outcomes Research, Minneapolis, MN, USA. Anne.M.Joseph@med.va.gov PY - 2003 SP - 429 EP - 441 VL - 45 IS - 6 SN - 0033-0620, 0033-0620 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Bupropion KW - 01ZG3TPX31 KW - Nicotine KW - 6M3C89ZY6R KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Antidepressive Agents, Second-Generation -- adverse effects KW - Smoking Cessation KW - Nicotine -- adverse effects KW - Bupropion -- adverse effects KW - Cardiovascular Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73376592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+cardiovascular+diseases&rft.atitle=Safety+issues+in+pharmacotherapy+for+smoking+in+patients+with+cardiovascular+disease.&rft.au=Joseph%2C+Anne+M%3BFu%2C+Steven+S&rft.aulast=Joseph&rft.aufirst=Anne&rft.date=2003-05-01&rft.volume=45&rft.issue=6&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Progress+in+cardiovascular+diseases&rft.issn=00330620&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-07-03 N1 - Date created - 2003-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical implications of mycotoxins and Stachybotrys. AN - 73345823; 12792245 AB - There has been considerable interest and concern in recent years regarding the potential health effects of mycotoxins in the indoor environment. Although the existence of mycotoxins has been known for several decades, relatively little is known about their effects in humans. What is known comes almost exclusively from studies of ingestion as the route of exposure. This review summarizes what is known regarding health effects of mycotoxins in general and specifically examines the evidence for the role of indoor exposure to the fungi of the genus Stachybotrys as a cause of disease in humans. Much work remains to be done in the area of mycotoxin research. The risk of health effects from ingestion seems much more widespread than from indoor airborne exposure, although the latter has received considerably more media attention. Rigorously controlled studies are needed to clarify these issues. JF - The American journal of the medical sciences AU - Revankar, Sanjay G AD - Dallas Veterans Affairs Medical Center, Texas, USA. sanjay.revankar@med.va.gov Y1 - 2003/05// PY - 2003 DA - May 2003 SP - 262 EP - 274 VL - 325 IS - 5 SN - 0002-9629, 0002-9629 KW - Aflatoxins KW - 0 KW - Fumonisins KW - Mycotoxins KW - Ochratoxins KW - Trichothecenes KW - Abridged Index Medicus KW - Index Medicus KW - Trichothecenes -- toxicity KW - Ochratoxins -- toxicity KW - Humans KW - Mycotoxicosis -- complications KW - Fumonisins -- toxicity KW - Aflatoxins -- toxicity KW - Lung Diseases -- etiology KW - Air Pollution, Indoor KW - Stachybotrys -- pathogenicity KW - Air Microbiology KW - Stachybotrys -- isolation & purification KW - Mycotoxins -- toxicity KW - Hemorrhage -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73345823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Clinical+implications+of+mycotoxins+and+Stachybotrys.&rft.au=Revankar%2C+Sanjay+G&rft.aulast=Revankar&rft.aufirst=Sanjay&rft.date=2003-05-01&rft.volume=325&rft.issue=5&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-06-19 N1 - Date created - 2003-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Shock-like sensations during venlafaxine withdrawal. AN - 73269725; 12741444 AB - Electric shock-like sensations may occur after cessation of treatment with serotonin selective reuptake inhibitors but are reported in the literature only rarely with discontinuation of venlafaxine. Two patients experienced severe shock-like sensations during venlafaxine withdrawal. For both patients symptoms occurred with lowering of the dosage and persisted for 5 days after complete discontinuation of the drug. These sensations may represent significant alteration of neuronal activity in the central nervous system. JF - Pharmacotherapy AU - Reeves, Roy R AU - Mack, James E AU - Beddingfield, John J AD - Department of Psychiatry, Montgomery VA Medical Center, and the School of Medicine, University of Mississippi, Jackson, Mississippi 39216, USA. roy.reeves@med.va.gov Y1 - 2003/05// PY - 2003 DA - May 2003 SP - 678 EP - 681 VL - 23 IS - 5 SN - 0277-0008, 0277-0008 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Cyclohexanols KW - Venlafaxine Hydrochloride KW - 7D7RX5A8MO KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Substance Withdrawal Syndrome -- etiology KW - Antidepressive Agents, Second-Generation -- adverse effects KW - Sensation Disorders -- chemically induced KW - Cyclohexanols -- administration & dosage KW - Antidepressive Agents, Second-Generation -- administration & dosage KW - Cyclohexanols -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73269725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Shock-like+sensations+during+venlafaxine+withdrawal.&rft.au=Reeves%2C+Roy+R%3BMack%2C+James+E%3BBeddingfield%2C+John+J&rft.aulast=Reeves&rft.aufirst=Roy&rft.date=2003-05-01&rft.volume=23&rft.issue=5&rft.spage=678&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-12 N1 - Date created - 2003-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Radiation therapy of changes secondary to lung cancer and pneumonectomy on bone and Tc-99m depreotide imaging. AN - 73207869; 12702946 JF - Clinical nuclear medicine AU - Shih, Wei-Jen AU - Kiefer, Vickie AD - Nuclear Medicine Service, VA Medical Center, Lexington, Kentucky 40502, USA. wei-jen.shh@med.va.gov Y1 - 2003/05// PY - 2003 DA - May 2003 SP - 419 EP - 420 VL - 28 IS - 5 SN - 0363-9762, 0363-9762 KW - Organotechnetium Compounds KW - 0 KW - Radiopharmaceuticals KW - Somatostatin KW - 51110-01-1 KW - technetium Tc 99m depreotide KW - 9M48M2SF02 KW - Index Medicus KW - Carcinoma, Bronchogenic -- diagnostic imaging KW - Radiopharmaceuticals -- pharmacokinetics KW - Neoplasms, Squamous Cell -- surgery KW - Humans KW - Carcinoma, Bronchogenic -- surgery KW - Carcinoma, Bronchogenic -- radiotherapy KW - Spine -- metabolism KW - Neoplasms, Squamous Cell -- secondary KW - Radionuclide Imaging KW - Spine -- diagnostic imaging KW - Spine -- radiation effects KW - Pneumonectomy KW - Neoplasms, Squamous Cell -- radiotherapy KW - Middle Aged KW - Male KW - Lung Neoplasms -- radiotherapy KW - Sternum -- metabolism KW - Sternum -- radiation effects KW - Bone Marrow -- metabolism KW - Somatostatin -- analogs & derivatives KW - Lung Neoplasms -- diagnostic imaging KW - Lung Neoplasms -- surgery KW - Somatostatin -- pharmacokinetics KW - Bone Marrow -- diagnostic imaging KW - Radiation Injuries -- diagnostic imaging KW - Organotechnetium Compounds -- pharmacokinetics KW - Sternum -- diagnostic imaging KW - Bone Marrow -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73207869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+nuclear+medicine&rft.atitle=Radiation+therapy+of+changes+secondary+to+lung+cancer+and+pneumonectomy+on+bone+and+Tc-99m+depreotide+imaging.&rft.au=Shih%2C+Wei-Jen%3BKiefer%2C+Vickie&rft.aulast=Shih&rft.aufirst=Wei-Jen&rft.date=2003-05-01&rft.volume=28&rft.issue=5&rft.spage=419&rft.isbn=&rft.btitle=&rft.title=Clinical+nuclear+medicine&rft.issn=03639762&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-22 N1 - Date created - 2003-04-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effect of ethanol exposure on mitogen-activated protein kinase activity and expression in cultured rat astrocytes. AN - 73196848; 12686373 AB - The effects of ethanol exposures on mitogen-activated protein kinase (MAPK) activity were determined in confluent astrocyte monolayers prepared from neonatal rat cerebral cortex. Acute 30 min exposure to 50 mM ethanol had no significant effect on MAPK activity. However, chronic exposure to ethanol for 4 days elicited a concentration-dependent increase in the basal level of this enzyme activity with no parallel increase in its protein expression. In addition, the magnitude of MAPK activation by epidermal growth factor, basic fibroblast growth factor and platelet-derived growth factor was significantly increased above corresponding control values in cells chronically exposed to ethanol. Immunolabeling experiments indicated that the protein expression of receptors for these growth factors was unaffected by ethanol treatment. Our results suggest that even after chronic ethanol treatment, MAPK phosphorylation and, hence, activation remains elevated. JF - Neuroscience letters AU - Smith, Thomas L AU - Navratilova, Edita AD - Research Health Care Group (0-151), Southern AZ VA Health Care System, Tucson, AZ, USA. thomas.smith6@med.va.gov Y1 - 2003/05/01/ PY - 2003 DA - 2003 May 01 SP - 91 EP - 94 VL - 341 IS - 2 SN - 0304-3940, 0304-3940 KW - Central Nervous System Depressants KW - 0 KW - Platelet-Derived Growth Factor KW - Ethanol KW - 3K9958V90M KW - Epidermal Growth Factor KW - 62229-50-9 KW - Mitogen-Activated Protein Kinase 1 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 3 KW - Mitogen-Activated Protein Kinases KW - Index Medicus KW - Animals KW - Cerebral Cortex -- cytology KW - Platelet-Derived Growth Factor -- metabolism KW - Cerebral Cortex -- metabolism KW - Dose-Response Relationship, Drug KW - Rats KW - Animals, Newborn KW - Blotting, Western KW - Cells, Cultured KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Environmental Exposure KW - Time Factors KW - Epidermal Growth Factor -- metabolism KW - Central Nervous System Depressants -- pharmacology KW - Mitogen-Activated Protein Kinases -- metabolism KW - Ethanol -- pharmacology KW - Astrocytes -- drug effects KW - Astrocytes -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73196848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=The+effect+of+ethanol+exposure+on+mitogen-activated+protein+kinase+activity+and+expression+in+cultured+rat+astrocytes.&rft.au=Smith%2C+Thomas+L%3BNavratilova%2C+Edita&rft.aulast=Smith&rft.aufirst=Thomas&rft.date=2003-05-01&rft.volume=341&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-15 N1 - Date created - 2003-04-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats. AN - 73182041; 12692058 AB - The role of sensory neurones in colitis was studied by chemical denervation of primary sensory neurones as well as antagonism of the vanilloid receptor-1 (VR-1) in rats prior to administration of dextran sulphate sodium (DSS) to induce colitis. Neonatal rats were chemically denervated by subcutaneous administration of capsaicin; controls received capsaicin vehicle only. When animals reached maturity, colitis was induced by administration of 5% DSS in drinking water for seven days. Additionally, normal adult rats were treated with a VR-1 antagonist capsazepine (CPZ) or vehicle twice daily via an enema from day 0 to day 6 of the DSS regimen. Control rats were treated with an enema infusion of vehicle and 5% DSS, or without either an enema infusion or DSS in drinking water. For both groups of rats, severity of inflammation was quantitated by disease activity index (DAI), myeloperoxidase (MPO) activity, and histological examination. DSS induced active colitis in all control rats with resultant epithelial ulceration, crypt shortening, and neutrophil infiltration. Both neonatal capsaicinised rats and normal adult rats treated with CPZ enemas exhibited significantly lower levels of DAI, MPO, and histological damage compared with vehicle treated rats (p< 0.05). Neonatal capsaicinisation and local administration of CPZ prevents intestinal inflammation in a well established model of colitis indicating that primary sensory neurones possessing VR-1 receptors are required in the propagation of colonic inflammation. JF - Gut AU - Kihara, N AU - de la Fuente, S G AU - Fujino, K AU - Takahashi, T AU - Pappas, T N AU - Mantyh, C R AD - Department of Surgery, Duke University Medical Center and Veterans' Administration Hospital, Durham, NC 27710, USA. Y1 - 2003/05// PY - 2003 DA - May 2003 SP - 713 EP - 719 VL - 52 IS - 5 SN - 0017-5749, 0017-5749 KW - Receptors, Drug KW - 0 KW - TRPV Cation Channels KW - TRPV1 receptor KW - Dextran Sulfate KW - 9042-14-2 KW - Peroxidase KW - EC 1.11.1.7 KW - capsazepine KW - LFW48MY844 KW - Capsaicin KW - S07O44R1ZM KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Colon -- pathology KW - Peroxidase -- metabolism KW - Colon -- drug effects KW - Disease Models, Animal KW - Colon -- innervation KW - Denervation -- methods KW - Colitis, Ulcerative -- prevention & control KW - Colitis, Ulcerative -- pathology KW - Colitis, Ulcerative -- chemically induced KW - Capsaicin -- analogs & derivatives KW - Receptors, Drug -- antagonists & inhibitors KW - Neurons, Afferent -- physiology KW - Capsaicin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73182041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gut&rft.atitle=Vanilloid+receptor-1+containing+primary+sensory+neurones+mediate+dextran+sulphate+sodium+induced+colitis+in+rats.&rft.au=Kihara%2C+N%3Bde+la+Fuente%2C+S+G%3BFujino%2C+K%3BTakahashi%2C+T%3BPappas%2C+T+N%3BMantyh%2C+C+R&rft.aulast=Kihara&rft.aufirst=N&rft.date=2003-05-01&rft.volume=52&rft.issue=5&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Gut&rft.issn=00175749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-06-24 N1 - Date created - 2003-04-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Trends Pharmacol Sci. 2000 Apr;21(4):131-3 [10740286] Am J Pathol. 2000 Mar;156(3):775-80 [10702392] Eur J Pharmacol. 2000 Jun 16;398(2):309-15 [10854844] Brain Res. 2000 Jul 21;871(2):181-91 [10899285] Neurosci Lett. 2000 Oct 6;292(2):95-8 [10998557] Am J Pathol. 2000 Nov;157(5):1511-22 [11073811] Am J Physiol Gastrointest Liver Physiol. 2000 Dec;279(6):G1298-306 [11093954] Peptides. 2001 Sep;22(9):1439-46 [11514026] J Physiol Paris. 2001 Jan-Dec;95(1-6):181-8 [11595435] Genes Immun. 2001 Oct;2(6):309-16 [11607786] Am J Physiol Gastrointest Liver Physiol. 2001 Nov;281(5):G1322-8 [11668042] Eur J Pharmacol. 1980 Feb 8;61(3):303-7 [6153986] Gastroenterology. 1990 Mar;98(3):694-702 [1688816] J Intern Med Suppl. 1990;732:125-32 [2166522] Brain Res. 1991 Mar 1;542(2):212-8 [1709387] Pharmacol Rev. 1991 Jun;43(2):143-201 [1852779] Gastroenterology. 1991 Nov;101(5):1211-9 [1718806] Scand J Gastroenterol. 1992 Jul;27(7):529-37 [1641579] Br J Pharmacol. 1992 Oct;107(2):544-52 [1422598] Lab Invest. 1993 Aug;69(2):238-49 [8350599] Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):947-51 [7508124] J Physiol Paris. 1993;87(4):277-80 [8136795] Gastroenterology. 1994 May;106(5):1208-14 [7513664] Gastroenterology. 1994 Sep;107(3):657-65 [7915699] Digestion. 1995;56(3):259-64 [7544748] Am J Physiol. 1996 Jan;270(1 Pt 1):G79-86 [8772504] Gastroenterology. 1996 Nov;111(5):1272-80 [8898641] Am J Physiol. 1997 Feb;272(2 Pt 1):G272-80 [9124351] Pharmacol Ther. 1997;73(3):173-217 [9175155] Nature. 1997 Oct 23;389(6653):816-24 [9349813] J Clin Invest. 1998 Apr 15;101(8):1547-50 [9541482] Digestion. 1998 Jul-Aug;59(4):269-83 [9693197] Gastroenterology. 1998 Oct;115(4):874-82 [9753490] Science. 2000 Apr 14;288(5464):306-13 [10764638] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Fatal large-volume mouthwash ingestion in an adult: a review and the possible role of phenolic compound toxicity. AN - 71550051; 14984634 AB - To describe a case of fatal mouthwash ingestion and review possible sources of toxicity. Case report. Veterans Administration Medical Center. Single patient with massive mouthwash ingestion. This patient was a 45-year-old man who developed cardiovascular collapse and multiorgan system failure following a massive ingestion of mouthwash (almost 3 liters). His presentation was remarkable for a profound anion-gap metabolic acidosis and a significant osmolar gap. No other co-ingestants were identified, and he expired despite full supportive care including dialysis and mechanical ventilation. An autopsy failed to identify any other cause of death. Nonalcoholic ingredients of this mouthwash are phenolic compounds (eucalyptol, menthol, and thymol), and large-volume mouthwash ingestion will produce exposure in the reported toxic range of these ingredients. When ingested in large quantities, the phenolic compounds in mouthwash may contribute to a severe anion-gap metabolic acidosis and osmolar gap, multiorgan system failure, and death. These compounds, in addition to alcohol, may account for the adverse effects associated with massive mouthwash ingestion. JF - Journal of intensive care medicine AU - Soo Hoo, Guy W AU - Hinds, Robert L AU - Dinovo, Eugene AU - Renner, Stephen W AD - Pulmonary and Critical Care Section, VA Greater Los Angeles Healthcare System, UCLA School of Medicine 90073, USA. guy.soohoo@med.va.gov PY - 2003 SP - 150 EP - 155 VL - 18 IS - 3 SN - 0885-0666, 0885-0666 KW - Anti-Infective Agents, Local KW - 0 KW - Drug Combinations KW - Fixatives KW - Mouthwashes KW - Phenols KW - Salicylates KW - Terpenes KW - Menthol KW - 1490-04-6 KW - Thymol KW - 3J50XA376E KW - Listerine KW - 51273-66-6 KW - methyl salicylate KW - LAV5U5022Y KW - Index Medicus KW - Severity of Illness Index KW - Menthol -- poisoning KW - Anti-Infective Agents, Local -- poisoning KW - Autopsy KW - Fatal Outcome KW - Humans KW - Respiration, Artificial KW - Critical Care -- methods KW - Renal Dialysis KW - Cause of Death KW - Risk Factors KW - Drug Overdose KW - Fixatives -- poisoning KW - Middle Aged KW - Thymol -- poisoning KW - Eucalyptus -- poisoning KW - Alcoholism -- complications KW - Male KW - Acidosis -- therapy KW - Terpenes -- poisoning KW - Mouthwashes -- poisoning KW - Acidosis -- chemically induced KW - Mouthwashes -- chemistry KW - Multiple Organ Failure -- therapy KW - Multiple Organ Failure -- diagnosis KW - Salicylates -- chemistry KW - Terpenes -- chemistry KW - Multiple Organ Failure -- chemically induced KW - Phenols -- poisoning KW - Salicylates -- poisoning KW - Acidosis -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71550051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+intensive+care+medicine&rft.atitle=Fatal+large-volume+mouthwash+ingestion+in+an+adult%3A+a+review+and+the+possible+role+of+phenolic+compound+toxicity.&rft.au=Soo+Hoo%2C+Guy+W%3BHinds%2C+Robert+L%3BDinovo%2C+Eugene%3BRenner%2C+Stephen+W&rft.aulast=Soo+Hoo&rft.aufirst=Guy&rft.date=2003-05-01&rft.volume=18&rft.issue=3&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Journal+of+intensive+care+medicine&rft.issn=08850666&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-15 N1 - Date created - 2004-02-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Intensive Care Med. 2003 May-Jun;18(3):160-2 [14984636] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Human U251MG glioma cells expressing the membrane form of macrophage colony-stimulating factor (mM-CSF) are killed by human monocytes in vitro and are rejected within immunodeficient mice via paraptosis that is associated with increased expression of three different heat shock proteins AN - 18784160; 5649446 AB - Human U251MG glioma cells retrovirally transduced with the human gene for the membrane form of macrophage colony-stimulating factor (mM-CSF) were investigated. The clones, MG-2F11 and MG-2C4, that expressed the most mM-CSF, but not the viral vector or the parental U251MG cells, were killed by both murine and human monocyte/macrophages in cytotoxicity assays. MG-2F11 cells failed to form subcutaneous tumors in either nude or NIH-bg-nu-xidBR mice, while mice inoculated with the U251MG viral vector (MG-VV) cells developed tumors. Electron microscopy studies showed that 4 hours after subcutaneous injection, the mM-CSF-transduced cells began dying of a process that resembled paraptosis. The dying tumor cells were swollen and had extensive vacuolization of their mitochondria and endoplasm reticulum. This killing process was complete within 24 hours. Macrophage-like cells were immediately adjacent to the killed MG-2F11 cells. Immunohistological staining for the heat shock proteins HSP60, HSP70 and GRP94 (gp96) showed that 18 hours after inoculation into nude mice, the MG-2F11 injection site was two to four times more intensely stained than the MG-VV cells. This study shows that human gliomas transduced with mM-CSF have the potential to be used as a safe live tumor cell vaccine. JF - Cancer Gene Therapy AU - Jadus, M R AU - Chen, Y AU - Boldaji, M T AU - Delgado, C AU - Sanchez, R AU - Douglass, T AU - Al-Atar, U AU - Schulz, W AU - Lloyd, C AU - Wepsic, H T AD - Box 113, Diagnostic and Molecular Medicine Service, Veterans Affairs Medical Center, 5901 E 7th Street, Long Beach, CA, USA, martin.jadus@med.va.gov Y1 - 2003/05// PY - 2003 DA - May 2003 SP - 411 EP - 420 VL - 10 IS - 5 SN - 0929-1903, 0929-1903 KW - GRP94 protein KW - Hsp60 protein KW - Hsp70 protein KW - man KW - nude mice KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Bioengineering Abstracts KW - W3 33181:Gene therapy vectors KW - W 30965:Miscellaneous, Reviews KW - W4 120:Genetic Engineering in Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18784160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Gene+Therapy&rft.atitle=Human+U251MG+glioma+cells+expressing+the+membrane+form+of+macrophage+colony-stimulating+factor+%28mM-CSF%29+are+killed+by+human+monocytes+in+vitro+and+are+rejected+within+immunodeficient+mice+via+paraptosis+that+is+associated+with+increased+expression+of+three+different+heat+shock+proteins&rft.au=Jadus%2C+M+R%3BChen%2C+Y%3BBoldaji%2C+M+T%3BDelgado%2C+C%3BSanchez%2C+R%3BDouglass%2C+T%3BAl-Atar%2C+U%3BSchulz%2C+W%3BLloyd%2C+C%3BWepsic%2C+H+T&rft.aulast=Jadus&rft.aufirst=M&rft.date=2003-05-01&rft.volume=10&rft.issue=5&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Cancer+Gene+Therapy&rft.issn=09291903&rft_id=info:doi/10.1038%2Fsj.cgt.7700583 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1038/sj.cgt.7700583 ER - TY - JOUR T1 - Fatal lactic acidosis and acute renal failure after addition of tenofovir to an antiretroviral regimen containing didanosine. AN - 73181803; 12684925 AB - We describe a 49-year-old man with human immunodeficiency virus infection and stable chronic renal insufficiency who developed acute oliguric renal failure and severe lactic acidosis and who died several weeks after tenofovir was added to an antiretroviral regimen that included didanosine. Although the role of tenofovir in precipitating acute renal failure is unclear, progressive accumulation of the drug and pharmacologic interaction that caused increased levels of didanosine were the likely antecedents of increased mitochondrial toxicity that led to lactic acidosis. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Murphy, Melissa D AU - O'Hearn, Mary AU - Chou, Sunwen AD - Infectious Disease Section, Veterans Affairs Medical Center, and Oregon Health and Science University, Portland, Oregon 97201, USA. melissa.murphy@med.va.gov Y1 - 2003/04/15/ PY - 2003 DA - 2003 Apr 15 SP - 1082 EP - 1085 VL - 36 IS - 8 KW - Anti-HIV Agents KW - 0 KW - Organophosphonates KW - Organophosphorus Compounds KW - Tenofovir KW - 99YXE507IL KW - Adenine KW - JAC85A2161 KW - Didanosine KW - K3GDH6OH08 KW - Index Medicus KW - Fatal Outcome KW - Humans KW - Mitochondria -- drug effects KW - Antiretroviral Therapy, Highly Active KW - Middle Aged KW - Drug Synergism KW - Male KW - Acidosis, Lactic -- chemically induced KW - Acute Kidney Injury -- chemically induced KW - Anti-HIV Agents -- adverse effects KW - Organophosphorus Compounds -- adverse effects KW - Adenine -- analogs & derivatives KW - Adenine -- adverse effects KW - Didanosine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73181803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Fatal+lactic+acidosis+and+acute+renal+failure+after+addition+of+tenofovir+to+an+antiretroviral+regimen+containing+didanosine.&rft.au=Murphy%2C+Melissa+D%3BO%27Hearn%2C+Mary%3BChou%2C+Sunwen&rft.aulast=Murphy&rft.aufirst=Melissa&rft.date=2003-04-15&rft.volume=36&rft.issue=8&rft.spage=1082&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-23 N1 - Date created - 2003-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Two brief alcohol-screening tests From the Alcohol Use Disorders Identification Test (AUDIT): validation in a female Veterans Affairs patient population. AN - 73197895; 12695273 AB - Primary care physicians need a brief alcohol questionnaire that identifies hazardous drinking and alcohol use disorders. The Alcohol Use Disorders Identification Test (AUDIT) questions 1 through 3 (AUDIT-C), and AUDIT question 3 alone are effective alcohol-screening tests in male Veterans Affairs (VA) patients, but have not been validated in women. Female VA patients (n = 393) completed self-administered questionnaires, including the 10-item AUDIT and a previously proposed modification to AUDIT question 3 with a sex-specific threshold for binge drinking (>/=4 drinks/occasion), and in-person interviews with the Alcohol Use Disorder and Associated Disabilities Interview Schedule. The AUDIT-C, AUDIT question 3 alone, and the 10-item AUDIT were each evaluated with and without the sex-specific binge question and compared with past-year hazardous drinking (>7 drinks/week or >/=4 drinks/occasion) and/or active Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition alcohol abuse or dependence, based on interviews. Eighty-nine women (22.6%) met interview criteria for past-year hazardous drinking and/or active alcohol abuse or dependence. Standard and sex-specific AUDIT-Cs were sensitive (0.81 and 0.84, respectively) and specific (0.86 and 0.85, respectively). Their areas under the receiver operating characteristic curves were equivalent (0.91, and 0.92, respectively) and slightly higher than for the standard 10-item AUDIT (0.87). A single, sex-specific question about binge drinking (modified AUDIT question 3) had a sensitivity of 0.69 and specificity of 0.94, whereas the standard AUDIT question 3 was specific (0.96) but relatively insensitive (0.45). The standard and sex-specific AUDIT-Cs are effective screening tests for past-year hazardous drinking and/or active alcohol abuse or dependence in female patients in a VA study. JF - Archives of internal medicine AU - Bradley, Katharine A AU - Bush, Kristen R AU - Epler, Amee J AU - Dobie, Dorcas J AU - Davis, Tania M AU - Sporleder, Jennifer L AU - Maynard, Charles AU - Burman, Marcia L AU - Kivlahan, Daniel R AD - Veteran Women's Alcohol Problems Study, Department of Veterans Affairs, Veterans Health Administration, Veterans Affairs Puget Sound Health Care System, Health Services Research and Development Service, Seattle, WA 98109, USA. willi@u.washington.edu Y1 - 2003/04/14/ PY - 2003 DA - 2003 Apr 14 SP - 821 EP - 829 VL - 163 IS - 7 SN - 0003-9926, 0003-9926 KW - Abridged Index Medicus KW - Index Medicus KW - Veterans KW - Humans KW - Cost-Benefit Analysis KW - Adult KW - Surveys and Questionnaires KW - Aged KW - Predictive Value of Tests KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Prevalence KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Mass Screening -- economics KW - Alcoholism -- economics KW - Alcohol Drinking KW - Mass Screening -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73197895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Two+brief+alcohol-screening+tests+From+the+Alcohol+Use+Disorders+Identification+Test+%28AUDIT%29%3A+validation+in+a+female+Veterans+Affairs+patient+population.&rft.au=Bradley%2C+Katharine+A%3BBush%2C+Kristen+R%3BEpler%2C+Amee+J%3BDobie%2C+Dorcas+J%3BDavis%2C+Tania+M%3BSporleder%2C+Jennifer+L%3BMaynard%2C+Charles%3BBurman%2C+Marcia+L%3BKivlahan%2C+Daniel+R&rft.aulast=Bradley&rft.aufirst=Katharine&rft.date=2003-04-14&rft.volume=163&rft.issue=7&rft.spage=821&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-06 N1 - Date created - 2003-04-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quality of Life with and without Aphasia AN - 85329715; llba-200308847 AB - Although the social approach to managing aphasia is designed to improve the quality of life (QOL) of the aphasic person, the influence of being aphasic on different facets of QOL is unknown. To delineate socially valid therapy targets, we examined 24 facets of QOL proposed by the World Health Organization (WHO) to determine which facets differentiate QOL between aphasic & nonaphasic people. A prospective, observational, non-randomized group design was employed. Two measures - the WHO QOL Instrument, Short Form (WHO QOL-BREF) & the Psychosocial Well-Being Index (PWI) - were administered to 18 adults with chronic aphasia & 18 nonaphasic adults. Indices of determination & degrees of overlap were calculated to determine which of the 24 facets were best in differentiating between the aphasic & nonaphasic groups. Facets within three domains - level of independence, social relationships, & environment - were best in distinguishing QOL between the aphasic & nonaphasic groups. In conclusion, therapy that focuses on situation-specific communication & societal participation appears to be most appropriate for enhancing the QOL of people with chronic aphasia. 3 Tables, 38 References. Adapted from the source document JF - Aphasiology AU - Ross, Katherine B AU - Wertz, Robert T AD - Audiology & Speech Pathology Dept, Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ katherine.ross3@med.va.gov Y1 - 2003/04// PY - 2003 DA - Apr 2003 SP - 355 EP - 364 VL - 17 IS - 4 SN - 0268-7038, 0268-7038 KW - *Language Therapy (44400) KW - *Aphasia (03400) KW - *Psychometric Analysis (69210) KW - *Communicative Competence (13650) KW - *Diagnostic Tests (18550) KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85329715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Quality+of+Life+with+and+without+Aphasia&rft.au=Ross%2C+Katherine+B%3BWertz%2C+Robert+T&rft.aulast=Ross&rft.aufirst=Katherine&rft.date=2003-04-01&rft.volume=17&rft.issue=4&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2003-10-01 N1 - Last updated - 2014-06-17 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - *Aphasia (03400); *Psychometric Analysis (69210); *Diagnostic Tests (18550); *Communicative Competence (13650); *Language Therapy (44400) ER - TY - JOUR T1 - Six-month neuropsychological outcome of medical intensive care unit patients. AN - 85264385; pmid-12682497 AB - OBJECTIVE: To examine neuropsychological function, depression, and quality of life 6 months after discharge in patients who received mechanical ventilation in the intensive care unit. DESIGN: Prospective cohort study. SETTING: Tertiary care, medical and coronary intensive care unit of a university-based medical center. STUDY POPULATION: A total of 275 consecutive, mechanically ventilated patients from a medical intensive care unit were prospectively followed. At 6 months, 157 were alive, of whom 41 (26%) returned for extensive follow-up testing. MEASUREMENT AND MAIN RESULTS: Neuropsychological testing and assessment of depression and quality of life were performed at 6-month follow-up. Seven of 41 patients were excluded from further analysis due to preexisting cognitive impairment determined via surrogate interviews using the Modified Blessed Dementia Rating Scale and a review of medical records. On the basis of strict criteria derived from normative data, we found that 11 of 34 patients (32%) were neuropsychologically impaired. Impairment was generally diffuse but occurred primarily in areas of psychomotor speed, visual and working memory, verbal fluency, and visuo-construction. The rate of neuropsychological deficits in the study population was markedly higher than population norms for mild dementia. Scores on the Geriatric Depression Scale-Short Form were significantly more abnormal in the neuropsychologically impaired group than in the nonimpaired group at hospital discharge (p =.04) and at 6-month follow-up (p =.02), and clinically significant depression was found in 27% of impaired subjects at hospital discharge and in 36% at 6-month follow-up. No differences were observed between groups in quality of life as measured with the Short Form Health Survey-12 at discharge or 6-month follow-up. CONCLUSIONS: Prolonged neuropsychological impairment is common among survivors of the medical intensive care unit and occurs with greater than anticipated frequency when compared with relevant normative data. Future investigations are warranted to elucidate the nature of the association between critical illness, neuropsychological impairment, depression, and decreased quality of life. JF - Critical Care Medicine AU - Jackson, James C AU - Hart, Robert P AU - Gordon, Sharon M AU - Shintani Ayumi AU - Truman, Brenda AU - May, Lisa AU - Wesley, Ely E AD - Department of Internal Medicine, Division of General Internal Medicine and Center for Health Services Research and the Geriatric Research Education and Clinical Center of the Veterans Administration Tennessee Valley Healthcare System, Nashville, TN, USA. PY - 2003 SP - 1226 EP - 1234 VL - 31 IS - 4 SN - 0090-3493, 0090-3493 KW - APACHE KW - Prospective Studies KW - Depression KW - Support, U.S. Gov't, P.H.S. KW - Length of Stay KW - Human KW - Middle Age KW - Support, Non-U.S. Gov't KW - Quality of Life KW - Male KW - Female KW - Cognition Disorders KW - Intensive Care Units KW - Respiration, Artificial KW - Neuropsychological Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85264385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+Care+Medicine&rft.atitle=Six-month+neuropsychological+outcome+of+medical+intensive+care+unit+patients.&rft.au=Jackson%2C+James+C%3BHart%2C+Robert+P%3BGordon%2C+Sharon+M%3BShintani+Ayumi%3BTruman%2C+Brenda%3BMay%2C+Lisa%3BWesley%2C+Ely+E&rft.aulast=Jackson&rft.aufirst=James&rft.date=2003-04-01&rft.volume=31&rft.issue=4&rft.spage=1226&rft.isbn=&rft.btitle=&rft.title=Critical+Care+Medicine&rft.issn=00903493&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Latency of the pupil light reflex: sample rate, stimulus intensity, and variation in normal subjects. AN - 85263366; pmid-12657591 AB - PURPOSE. To investigate the clinical usefulness of the latency of the pupil light reflex by optimizing its measurement, characterizing its variability, and determining the sensitivity of pupil latency as a function of stimulus input in normal subjects. METHODS. Computerized binocular infrared pupillography was performed in 14 eyes of seven healthy subjects. Pupils were recorded simultaneously at 60 and 1000 Hz. Each eye was alternatively stimulated eight times for 50 ms every 2.5 seconds, increasing by 0.5 log units over a 2.0-log-unit range. To determine intersubject and intereye variability, 98 eyes of 49 healthy subjects were recorded at 60 Hz over a 3.0-log-unit range (15 degrees radius stimulation, four repetitions at each intensity). RESULTS. Accuracy and resolution of latency were limited by the number of light reflexes used to estimate the average latency and were significantly affected by sampling rate when the number of reflexes recorded was fewer than four. Binocular recording and interpolation of the 60-Hz recording to 300 Hz added resolution to the latency. Biological variability contributed more to interindividual variability than did measurement variability. The range of intereye afferent asymmetry of latency in normal subjects was only between 8.3 and 35 ms-less with brighter stimulus intensity. CONCLUSIONS. An optimal method for determination of the onset of the pupil light reflex was devised that consisted of filtering, interpolation of pupil recordings, and analysis of the first and second derivative of the pupil movement. Most of the variability in latency as a function of intensity in normal subjects was due to interindividual variation and latency was well matched between the two eyes of the subjects. JF - Investigative Ophthalmology & Visual Science AU - Bergamin Oliver AU - Kardon, Randy H AD - Department of Ophthalmology and Visual Sciences and Veterans Administration Hospital, University of Iowa, Iowa City, Iowa. Department of Ophthalmology, University Hospital of Zürich, Zürich, Switzerland. PY - 2003 SP - 1546 EP - 1554 VL - 44 IS - 4 SN - 0146-0404, 0146-0404 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85263366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+Ophthalmology+%26+Visual+Science&rft.atitle=Latency+of+the+pupil+light+reflex%3A+sample+rate%2C+stimulus+intensity%2C+and+variation+in+normal+subjects.&rft.au=Bergamin+Oliver%3BKardon%2C+Randy+H&rft.aulast=Bergamin+Oliver&rft.aufirst=&rft.date=2003-04-01&rft.volume=44&rft.issue=4&rft.spage=1546&rft.isbn=&rft.btitle=&rft.title=Investigative+Ophthalmology+%26+Visual+Science&rft.issn=01460404&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - An holistic approach to substance abuse treatment. AN - 73579994; 12924747 AB - The purpose of this article is to describe a model outpatient substance abuse treatment program. This program is designed to provide patients with not only traditional modalities of treatment such as individual, group, and family therapy, but also to provide an opportunity for patients to express thoughts and feelings through holistic modalities. These modalities include dance/movement therapy, Tai Chi, art therapy, leisure and recreational skills, spiritual growth and development, cultural awareness and appreciation, vocational services, psychiatric care and physical health. The authors describe features of this program that they believe to be unique and that focus on ways to help patients develop a stronger sense of self-identity, self-esteem and self-confidence. JF - Journal of psychoactive drugs AU - Breslin, Kathy T AU - Reed, Maria R AU - Malone, Sandra B AD - Drug Dependency Treatment Program, Veterans Administration, Maryland Health Care System, Baltimore, Maryland 21201, USA. PY - 2003 SP - 247 EP - 251 VL - 35 IS - 2 SN - 0279-1072, 0279-1072 KW - Index Medicus KW - Tai Ji -- methods KW - Humans KW - Sensory Art Therapies -- methods KW - Self-Help Groups KW - Substance-Related Disorders -- therapy KW - Holistic Health KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73579994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=An+holistic+approach+to+substance+abuse+treatment.&rft.au=Breslin%2C+Kathy+T%3BReed%2C+Maria+R%3BMalone%2C+Sandra+B&rft.aulast=Breslin&rft.aufirst=Kathy&rft.date=2003-04-01&rft.volume=35&rft.issue=2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-09-17 N1 - Date created - 2003-08-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Qualitative and quantitative assessments of HAART adherence of substance-abusing women. AN - 73477509; 12856345 AB - This study was set up to examine factors affecting adherence to highly active antiretroviral therapy (HAART) by substance abusing women and to conduct a pilot study of a reminder device intervention. Three focus groups totaling 24 HIV-positive women developed priority lists of issues affecting adherence. Another group of 24 HIV-positive women received a timer-reminder with structured interviews on adherence at baseline and two monthly follow up intervals. Focus groups described key barriers to HAART adherence as substance abuse, forgetting, feeling ill, others' negative attitudes, obtaining refills and confidentiality. Primary disadvantages to HAART were side effects, pill-taking schedule and burden of taking medications. Facilitators included reminders (e.g. pill boxes) and spirituality. After receiving the reminder, missing a dose was less common (p < 0.05) due to sleeping through dose, being busy and feeling too good while a favourable trend (p = 0.07) was seen for change in daily routine and having too many pills to take. Although well accepted, the reminder did not affect the proportion missing a dose in the past two weeks: baseline (33%), first follow-up (30%) and second follow-up (30%). Forgetting to take HAART was only one of many cited barriers to adherence in these HIV-positive women; well-received reminder devices did not affect adherence. To improve substance-abusing women's adherence, multidimensional interventions are warranted. JF - AIDS care AU - Powell-Cope, G M AU - White, J AU - Henkelman, E J AU - Turner, B J AD - James A. Haley Veterans Administration Hospital, Tampa, FL, USA. Y1 - 2003/04// PY - 2003 DA - April 2003 SP - 239 EP - 249 VL - 15 IS - 2 SN - 0954-0121, 0954-0121 KW - Index Medicus KW - AIDS/HIV KW - Focus Groups KW - Humans KW - Adult KW - Pilot Projects KW - Female KW - Patient Compliance -- psychology KW - HIV Infections -- drug therapy KW - Antiretroviral Therapy, Highly Active KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73477509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Qualitative+and+quantitative+assessments+of+HAART+adherence+of+substance-abusing+women.&rft.au=Powell-Cope%2C+G+M%3BWhite%2C+J%3BHenkelman%2C+E+J%3BTurner%2C+B+J&rft.aulast=Powell-Cope&rft.aufirst=G&rft.date=2003-04-01&rft.volume=15&rft.issue=2&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-04 N1 - Date created - 2003-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dropout from 12-step self-help groups: prevalence, predictors, and counteracting treatment influences. AN - 73365294; 12810145 AB - Attendance at 12-step self-help groups is frequently recommended as an adjunct to professional substance use disorder (SUD) treatment, yet patient dropout from these groups is common. This study assessed the prevalence, predictors, and treatment-related factors affecting dropout in the first year following treatment for 2,778 male patients. Of these, 91% (2,518) were identified as having attended 12-step groups either in the 90 days prior to, or during, treatment. At 1-year followup 40% had dropped out. A number of baseline factors predicted dropout. Importantly, patients who initiated 12-step behaviors during treatment were less likely to drop out. Further findings suggest patients at highest risk for dropout may be at lower risk if treated in a more supportive environment. Clinicians may decrease the likelihood of dropout directly, by screening for risk factors and focusing facilitation efforts accordingly, and indirectly, by increasing the supportiveness of the treatment environment, and facilitating 12-step involvement during treatment. JF - Journal of substance abuse treatment AU - Kelly, John F AU - Moos, Rudolf AD - Center for Healthcare Evaluation, Veterans Affairs Palo Alto Healthcare System (MPD-152) and Stanford University School of Medicine, 795 Willow Road, Menlo Park, CA 94025, USA. john.kelly4@med.va.gov Y1 - 2003/04// PY - 2003 DA - April 2003 SP - 241 EP - 250 VL - 24 IS - 3 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Veterans KW - Logistic Models KW - Risk Factors KW - Humans KW - Adult KW - Treatment Outcome KW - Temperance -- psychology KW - Aged KW - Social Support KW - Middle Aged KW - Male KW - Social Environment KW - Patient Dropouts -- statistics & numerical data KW - Patient Dropouts -- psychology KW - Alcoholics Anonymous KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73365294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Dropout+from+12-step+self-help+groups%3A+prevalence%2C+predictors%2C+and+counteracting+treatment+influences.&rft.au=Kelly%2C+John+F%3BMoos%2C+Rudolf&rft.aulast=Kelly&rft.aufirst=John&rft.date=2003-04-01&rft.volume=24&rft.issue=3&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-19 N1 - Date created - 2003-06-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Parathyroid adenomas versus four-gland hyperplasia as the cause of primary hyperparathyroidism in patients with prolonged lithium therapy. AN - 73138028; 12658498 AB - Chronic lithium therapy in patients with affective psychiatric disorders has been implicated as the cause of hypercalcemia and primary hyperparathyroidism. Our objective was to evaluate whether primary hyperparathyroidism was caused by an adenoma or four-gland hyperplasia. The medical records of 15 patients with affective psychiatric disorders who were treated with chronic lithium therapy from 1982 to 1997, all of whom were operated on for primary hyperparathyroidism, were reviewed. Data on age, symptoms, duration of lithium therapy, pre- and postoperative calcium levels, and parathyroid hormone levels were collected. Parathyroid histology for each patient was independently and blindly reviewed. The mean age was 58 +/- 10 years, the mean duration of lithium therapy 10.7 +/- 6 years, and the mean preoperative calcium level 11.7 +/- 0.5 mg/dl. All patients underwent bilateral neck exploration with selective resection of enlarged glands. Of the 15 patients, 14 (92%) had adenomas (11 single, 3 double), and 1 (8%) had four-gland hyperplasia. All patients were rendered eucalcemic, with a postoperative calcium level of 9.2 +/- 0.5 mg/dl ( p < 0.005). All patients resumed their lithium therapy, with 1 of 15 patients developing recurrent hyperparathyroidism 2 years following the first operation; this patient required reexploration, at which time an adenoma was resected. In our experience hyperparathyroidism in patients who have undergone prolonged therapy with lithium is associated with a high incidence of parathyroid adenomas versus four-gland hyperplasia. This suggests that lithium selectively stimulates growth of parathyroid adenomas in susceptible patients, who are best treated with adenoma excision rather than subtotal parathyroidectomy. JF - World journal of surgery AU - Awad, Samir S AU - Miskulin, Judiann AU - Thompson, Norman AD - Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston Veterans Administration Medical Center, Surgical Service (112), 2002 Holcombe Boulevard, Houston, Texas 77030, USA. sawad@bcm.tmc.edu Y1 - 2003/04// PY - 2003 DA - April 2003 SP - 486 EP - 488 VL - 27 IS - 4 SN - 0364-2313, 0364-2313 KW - Antidepressive Agents KW - 0 KW - Lithium KW - 9FN79X2M3F KW - Index Medicus KW - Hyperplasia KW - Humans KW - Bipolar Disorder -- drug therapy KW - Adult KW - Hypercalcemia -- chemically induced KW - Aged KW - Middle Aged KW - Recurrence KW - Male KW - Female KW - Hyperparathyroidism -- chemically induced KW - Adenoma -- chemically induced KW - Parathyroid Neoplasms -- chemically induced KW - Parathyroid Glands -- pathology KW - Parathyroid Glands -- drug effects KW - Antidepressive Agents -- adverse effects KW - Lithium -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73138028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=World+journal+of+surgery&rft.atitle=Parathyroid+adenomas+versus+four-gland+hyperplasia+as+the+cause+of+primary+hyperparathyroidism+in+patients+with+prolonged+lithium+therapy.&rft.au=Awad%2C+Samir+S%3BMiskulin%2C+Judiann%3BThompson%2C+Norman&rft.aulast=Awad&rft.aufirst=Samir&rft.date=2003-04-01&rft.volume=27&rft.issue=4&rft.spage=486&rft.isbn=&rft.btitle=&rft.title=World+journal+of+surgery&rft.issn=03642313&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-09-24 N1 - Date created - 2003-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Major depression in patients with substance use disorders: relationship to 12-Step self-help involvement and substance use outcomes. AN - 73137020; 12653819 AB - Many patients treated for substance use disorders (SUDs) who become involved in 12-Step self-help groups have improved treatment outcomes. However, due to high rates of psychiatric comorbidity and major depressive disorder (MDD), among SUD patients in particular, concerns have been raised over whether these benefits extend to dual diagnosis patients. This study examined the influence of comorbid MDD among patients with SUDs on 12-Step self-help group involvement and its relation to treatment outcome. A quasi-experimental, prospective, intact group design was used with assessments completed during treatment, and 1 and 2 years postdischarge. A total of 2161 male patients recruited during in-patient SUD treatment, of whom 110 had a comorbid MDD diagnosis (SUD-MDD) and 2051 were without psychiatric comorbidity (SUD-only). SUD-MDD patients were initially less socially involved in and derived progressively less benefit from 12-Step groups over time compared to the SUD-only group. However, substance use outcomes did not differ by diagnostic cohort. In contrast, despite using substantially more professional out-patient services, the SUD-MDD cohort continued to suffer significant levels of depression. Treatment providers should allocate more resources to targeting depressive symptoms in SUD-MDD patients. Furthermore, SUD-MDD patients may not assimilate as readily into, nor benefit as much from, traditional 12-Step self-help groups such as Alcoholics Anonymous, as psychiatrically non-comorbid patients. Newer, dual-diagnosis-specific, self-help groups may be a better fit for these patients, but await further study. JF - Addiction (Abingdon, England) AU - Kelly, John F AU - McKellar, John D AU - Moos, Rudolf AD - Center for Healthcare Evaluation, Veterans Affairs Palo Alto Healthcare System and Stanford University School of Medicine, Menlo Park, CA 94025, USA. john.kelly4@med.va.gov Y1 - 2003/04// PY - 2003 DA - April 2003 SP - 499 EP - 508 VL - 98 IS - 4 SN - 0965-2140, 0965-2140 KW - Index Medicus KW - Prospective Studies KW - Humans KW - Treatment Outcome KW - Diagnosis, Dual (Psychiatry) KW - Follow-Up Studies KW - Male KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- complications KW - Self-Help Groups KW - Depressive Disorder -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73137020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Major+depression+in+patients+with+substance+use+disorders%3A+relationship+to+12-Step+self-help+involvement+and+substance+use+outcomes.&rft.au=Kelly%2C+John+F%3BMcKellar%2C+John+D%3BMoos%2C+Rudolf&rft.aulast=Kelly&rft.aufirst=John&rft.date=2003-04-01&rft.volume=98&rft.issue=4&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-22 N1 - Date created - 2003-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Switching patients to aripiprazole from other antipsychotic agents: a multicenter randomized study. AN - 73136382; 12610718 AB - Switching patients from one antipsychotic to another can lead to tolerability problems or transient symptom exacerbations. It is important to compare switching strategies to determine which methods produce the best possible patient outcomes. To investigate the efficacy, safety and tolerability of three dosing strategies for switching chronic, stable patients with schizophrenia from current oral antipsychotic monotherapy to once-daily oral aripiprazole monotherapy. Patients in this 8-week, open-label, outpatient study were randomized to: 1). immediate initiation of 30 mg/day aripiprazole with simultaneous immediate discontinuation of current antipsychotic; 2). immediate initiation of 30 mg/day aripiprazole while tapering off current antipsychotic over 2 weeks; or 3). up-titrating aripiprazole to 30 mg/day over 2 weeks, while simultaneously tapering off current antipsychotic. Efficacy assessments included PANSS, CGI-S, and CGI-I scores. Safety assessments included: adverse events (AEs) recording, evaluation of extrapyramidal symptoms (EPS), vital signs, ECG, and clinical laboratory tests. Efficacy with aripiprazole was maintained during the study with numerical improvements compared with baseline in all three groups. The overall incidence of AEs was broadly comparable across all groups, and AEs were generally mild to moderate in severity and time-limited. Discontinuations due to AEs were comparable across the groups. No deterioration in EPS occurred in any group. The reduction in body weight and plasma prolactin levels following switch to aripiprazole were comparable across the three groups. Any of the three strategies evaluated can be used safely for switching patients to aripiprazole from antipsychotic monotherapy. Furthermore, patients' symptoms may continue to improve after switching to aripiprazole. JF - Psychopharmacology AU - Casey, Daniel E AU - Carson, William H AU - Saha, Anutosh R AU - Liebeskind, Amy AU - Ali, Mirza W AU - Jody, Darlene AU - Ingenito, Gary G AU - Aripiprazole Study Group AD - Mental Health Division (P3MIRECC), VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA. daniel.casey@med.va.gov ; Aripiprazole Study Group Y1 - 2003/04// PY - 2003 DA - April 2003 SP - 391 EP - 399 VL - 166 IS - 4 SN - 0033-3158, 0033-3158 KW - Antipsychotic Agents KW - 0 KW - Piperazines KW - Quinolones KW - Aripiprazole KW - 82VFR53I78 KW - Index Medicus KW - Drug Administration Schedule KW - Humans KW - Adult KW - Treatment Outcome KW - Male KW - Female KW - Antipsychotic Agents -- administration & dosage KW - Quinolones -- adverse effects KW - Quinolones -- therapeutic use KW - Piperazines -- therapeutic use KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenia -- drug therapy KW - Piperazines -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Piperazines -- administration & dosage KW - Quinolones -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73136382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Switching+patients+to+aripiprazole+from+other+antipsychotic+agents%3A+a+multicenter+randomized+study.&rft.au=Casey%2C+Daniel+E%3BCarson%2C+William+H%3BSaha%2C+Anutosh+R%3BLiebeskind%2C+Amy%3BAli%2C+Mirza+W%3BJody%2C+Darlene%3BIngenito%2C+Gary+G%3BAripiprazole+Study+Group&rft.aulast=Casey&rft.aufirst=Daniel&rft.date=2003-04-01&rft.volume=166&rft.issue=4&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-07-24 N1 - Date created - 2003-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - HIV therapy in 2003: consensus and controversy AN - 18805706; 5661546 AB - HIV therapy has well-established and substantial clinical benefits. Awareness of these benefits has brought many infected persons into care. Many more infected persons would be treated were it not for the frequent side effects associated with antiretroviral drugs. All antiretroviral agents can cause both short-term and long-term toxicities. This is a particularly vexing problem as current data does not allow accurate predictions of treatment toxicities and, in many cases, side effects are only partially reversible. Moreover, therapy is frequently associated with the selection of drug-resistant viral isolates and incomplete viral suppression. This is commonly caused by inadequate medication adherence and leads to increasingly severe virologic failure. The present review will address both the striking advantages of HIV therapy as well as the ongoing challenges in its application. JF - AIDS AU - Volberding, P A AD - 4150 Clement Street (VAMC 111) University of California, San Francisco, CA 94121, USA, Paul.Volberding@med.va.gov Y1 - 2003/04// PY - 2003 DA - Apr 2003 SP - S4 EP - S11 VL - 17 SN - 0269-9370, 0269-9370 KW - HIV KW - man KW - Virology & AIDS Abstracts; Toxicology Abstracts KW - V 22004:AIDS: Clinical aspects KW - X 24113:Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18805706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=HIV+therapy+in+2003%3A+consensus+and+controversy&rft.au=Volberding%2C+P+A&rft.aulast=Volberding&rft.aufirst=P&rft.date=2003-04-01&rft.volume=17&rft.issue=&rft.spage=S4&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - CSF CRH in abstinent cocaine-dependent patients. AN - 73187708; 12686370 AB - Alterations in stress responsivity may be important in the vulnerability to become cocaine dependent. Thus, an index of hypothalamic-pituitary-adrenal (HPA) axis function was examined in abstinent cocaine-dependent patients. Cerebrospinal fluid (CSF) concentrations of corticotropin releasing factor (CRH) were determined in 29 abstinent cocaine-dependent patients and 66 normal controls. The results showed that there was no significant difference between the abstinent cocaine-dependent patients and normal controls for CSF CRH. Also, CSF CRH concentrations were not related to cocaine-craving scores in a cue-elicited cocaine-craving procedure. Thus, these data suggest that after protracted abstinence from cocaine there is no marked dysregulation of CRH systems as measured by CSF CRH concentrations. JF - Psychiatry research AU - Roy, Alec AU - Bissette, Garth AU - Williams, Redford AU - Berman, Jeffrey AU - Gonzalez, Bienvenido AD - Psychiatry Service (116A), Department of Veterans Affairs, New Jersey Healthcare System, 385 Tremont Avenue, East Orange, NJ 07018, USA. alec.roy@med.va.gov Y1 - 2003/03/25/ PY - 2003 DA - 2003 Mar 25 SP - 277 EP - 280 VL - 117 IS - 3 SN - 0165-1781, 0165-1781 KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - Cocaine KW - I5Y540LHVR KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Hypothalamo-Hypophyseal System -- physiopathology KW - Humans KW - Pituitary-Adrenal System -- physiopathology KW - Adult KW - Follow-Up Studies KW - Male KW - Hydrocortisone -- blood KW - Corticotropin-Releasing Hormone -- cerebrospinal fluid KW - Substance Withdrawal Syndrome -- etiology KW - Substance Withdrawal Syndrome -- cerebrospinal fluid KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73187708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=CSF+CRH+in+abstinent+cocaine-dependent+patients.&rft.au=Roy%2C+Alec%3BBissette%2C+Garth%3BWilliams%2C+Redford%3BBerman%2C+Jeffrey%3BGonzalez%2C+Bienvenido&rft.aulast=Roy&rft.aufirst=Alec&rft.date=2003-03-25&rft.volume=117&rft.issue=3&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-19 N1 - Date created - 2003-04-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Demographic, medical, and psychiatric factors in work and marital status after mild head injury. AN - 85379202; pmid-12802224 AB - To explore factors associated with long-term outcomes of work and marital status in individuals who had experienced a mild head injury (MHI), as well as those who had not.Population-based study using logistical regression analyses to investigate the impact of preinjury characteristics on work and marital status.Two groups of Vietnam-era Army veterans: 626 who had experienced a MHI an average of 8 years before examination, and 3,896 who had not.Demographic characteristics, concurrent medical conditions, early life psychiatric problems, loss of consciousness (LOC), and interactions among these variables were used to predict current work and marital status.Multiple variables were associated with work and marital status in the sample with MHI, accounting for approximately 23% and 17% of the variance in these two outcome variables, respectively. In contrast, the same factors accounted for significantly less variance in outcome in the sample without a head injury-13.3% and 9.4% for work and marital status, respectively.These findings suggest a more potent role for and increased vulnerability to the influence of demographic, medical, and psychiatric factors on outcomes after a MHI. That is, MHI itself moderates the influence of preinjury characteristics on work and marital status. In addition, in those who had a MHI, moderator relationships were found between education and LOC for both work and marital status. Similarly, complex moderator relationships among race, region of residence, and LOC were found for both work and marital status outcomes. JF - The Journal of head trauma rehabilitation AU - Vanderploeg, Rodney D AU - Curtiss, Glenn AU - Duchnick, Jennifer J AU - Luis, Cheryl A AD - The James A. Haley Veterans Affairs Medical Center, Defense and Veterans Head Injury Program, Psychology Service 116B, Tampa, FL 33612, USA. Rodney.Vanderploeg@med.va.gov Y1 - 2003/03// PY - 2003 DA - Mar 2003 SP - 148 EP - 163 VL - 18 IS - 2 SN - 0885-9701, 0885-9701 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Age Factors KW - *Brain Injuries: rehabilitation KW - Continental Population Groups KW - Educational Status KW - *Employment KW - Health Status KW - Humans KW - Logistic Models KW - Male KW - *Marital Status KW - Mental Disorders: complications KW - Outcome Assessment (Health Care) KW - Regression Analysis KW - Risk Factors KW - Unconsciousness: complications KW - United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85379202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+head+trauma+rehabilitation&rft.atitle=Demographic%2C+medical%2C+and+psychiatric+factors+in+work+and+marital+status+after+mild+head+injury.&rft.au=Vanderploeg%2C+Rodney+D%3BCurtiss%2C+Glenn%3BDuchnick%2C+Jennifer+J%3BLuis%2C+Cheryl+A&rft.aulast=Vanderploeg&rft.aufirst=Rodney&rft.date=2003-03-01&rft.volume=18&rft.issue=2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+head+trauma+rehabilitation&rft.issn=08859701&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Olfactory functioning in Gulf War-era veterans: relationships to war-zone duty, self-reported hazards exposures, and psychological distress. AN - 85372978; pmid-12666765 AB - To explore possible neurotoxic sequelae of Gulf War (GW) participation, olfactory identification performance, neurocognitive functioning, health perceptions, and emotional distress were assessed in 72 veterans deployed to the GW and 33 military personnel activated during the GW but not deployed to the war zone. Findings revealed that war-zone-exposed veterans reported more concerns about health, cognitive functioning, and depression than did their counterparts who did not see war-zone duty. There was no evidence that performances on olfactory or neurocognitive measures were related to war-zone duty or to self-reported exposure to GW toxicants. However, symptoms of emotional distress were positively correlated with self-report of health and cognitive complaints. Results do not provide support for the hypothesis that objectively-measured sensory (i.e., olfactory) or cognitive deficits are related to war-zone participation but do underscore the increasingly demonstrated association between self-reported health concerns and symptoms of emotional distress. JF - Journal of the International Neuropsychological Society : JINS AU - Vasterling, Jennifer J AU - Brailey, Kevin AU - Tomlin, Holly AU - Rice, Janet AU - Sutker, Patricia B AD - Mental Health Service Line, Veterans Affairs Medical Center, New Orleans, Louisiana 70112, USA. jennifer.vasterling@med.va.gov Y1 - 2003/03// PY - 2003 DA - Mar 2003 SP - 407 EP - 418 VL - 9 IS - 3 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Chemical Warfare KW - *Environmental Exposure KW - Female KW - Humans KW - Male KW - Middle Aged KW - Military Personnel: psychology KW - Neuropsychological Tests KW - Olfaction Disorders: chemically induced KW - Olfaction Disorders: physiopathology KW - Olfaction Disorders: psychology KW - Persian Gulf Syndrome: epidemiology KW - *Persian Gulf Syndrome: physiopathology KW - Persian Gulf Syndrome: psychology KW - Psychomotor Performance KW - *Self-Assessment KW - Stress, Psychological: epidemiology KW - *Veterans KW - War UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85372978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=Olfactory+functioning+in+Gulf+War-era+veterans%3A+relationships+to+war-zone+duty%2C+self-reported+hazards+exposures%2C+and+psychological+distress.&rft.au=Vasterling%2C+Jennifer+J%3BBrailey%2C+Kevin%3BTomlin%2C+Holly%3BRice%2C+Janet%3BSutker%2C+Patricia+B&rft.aulast=Vasterling&rft.aufirst=Jennifer&rft.date=2003-03-01&rft.volume=9&rft.issue=3&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Epidemiology and pathophysiology of symptomatic gastroesophageal reflux disease. AN - 85368722; pmid-12644025 AB - Symptomatic, or nonerosive, gastroesophageal reflux disease (GERD) is the most common presentation of GERD. Patients with symptomatic GERD more frequently are younger, female, weigh less, and are less likely to have a hiatal hernia compared with patients who have erosive GERD. Physiologically, these patients demonstrate minimal esophageal motor abnormalities. However, despite a common clinical presentation and similar endoscopic findings, symptomatic GERD is comprised of a heterogeneous group of patients. There are several identifiable subgroups differentiated by the underlying mechanisms causing their heartburn symptoms, distinctions that may explain the relatively low symptom response rate to potent antireflux treatment observed among these patients as compared with those with erosive esophagitis. JF - The American journal of gastroenterology AU - Fass, Ronnie AD - Section of Gastroenterology (1-111G-1), Southern Arizona Veterans Administration Health Care System, Tucson, AZ 85723-0001, USA. Y1 - 2003/03// PY - 2003 DA - Mar 2003 SP - S2 EP - S7 VL - 98 IS - 3 Suppl SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Clinical Trials as Topic KW - *Gastroesophageal Reflux: epidemiology KW - *Gastroesophageal Reflux: physiopathology KW - Humans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85368722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Epidemiology+and+pathophysiology+of+symptomatic+gastroesophageal+reflux+disease.&rft.au=Fass%2C+Ronnie&rft.aulast=Fass&rft.aufirst=Ronnie&rft.date=2003-03-01&rft.volume=98&rft.issue=3+Suppl&rft.spage=S2&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The Burden of Stroke Scale (BOSS): Validating Patient-Reported Communication Difficulty and Associated Psychological Distress in Stroke Survivors AN - 85351514; llba-200306006 AB - This study was designed to examine the discriminative & concurrent validity of the BOSS (Burden of Stroke Scale) Communication Difficulty (CD) & Communication-Associated Psychological Distress (CAPD) scales. A secondary purpose was to provide a preliminary examination of the relationships between the BOSS CD & CAPD scales & aspects of subjective well-being, including the frequency with which participants reported experiencing general positive & negative emotional states. The BOSS was administered as a face-to-face interviewer-assisted survey to 281 medically stable, community-dwelling stroke survivors selected from five collaborating centers in the USA. Prior to administration of the BOSS, all subjects were rated for severity of communication impairment using the Boston Diagnostic Aphasia Examination (BDAE) severity rating scale (Goodglass, Kaplan, & Baressi, 2001) & were administered Subtest 8 of the Revised Token Test (RTT), (McNeil & Prescott, 1978). The discriminant validity of the BOSS CD & CAPD scales was examined by comparing scores in stroke survivors with (N = 135) & without (N = 146) communication impairment, & within the communicatively impaired sample when classified according to BDAE ratings & RTT performance. Concurrent validity of the BOSS CD & CAPD scales was examined by correlating BOSS scores with BDAE ratings & RTT performance. Finally, correlations between the BOSS CAPD, BOSS CD, positive mood, & negative mood scales were calculated. Statistical analyses revealed significant differences between communicatively impaired & non-communicatively impaired subjects on the BOSS CD & CAPD scales, as well as significant differences between communicatively impaired subjects of differing severity levels classified both by BDAE severity ratings & RTT performance. Correlational analyses revealed moderately strong relationships among the BOSS CD scale, BDAE severity ratings, & RTT performance. Finally, correlations among the BOSS CAPD, CD, Positive Mood, & Negative Mood scales revealed true co-varying relationships of moderate strength between the BOSS CAPD & CD scales, & also between the CAPD & negative mood scales. 7 Tables, 1 Figure, 3 Appendixes, 32 References. Adapted from the source document JF - Aphasiology AU - Doyle, Patrick J AU - McNeil, Malcolm R AU - Hula, William D AU - Mikolic, Joseph M AD - Geriatric Research Education & Clinical Center, VA patrick.doyle@med.va.gov Y1 - 2003/03// PY - 2003 DA - Mar 2003 SP - 291 EP - 304 VL - 17 IS - 3 SN - 0268-7038, 0268-7038 KW - *Emotions (21600) KW - *Aphasia (03400) KW - *Practitioner Patient Relationship (66830) KW - *Communicative Competence (13650) KW - *Brain Damage (09400) KW - *Diagnostic Tests (18550) KW - *Test Validity and Reliability (88800) KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85351514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=The+Burden+of+Stroke+Scale+%28BOSS%29%3A+Validating+Patient-Reported+Communication+Difficulty+and+Associated+Psychological+Distress+in+Stroke+Survivors&rft.au=Doyle%2C+Patrick+J%3BMcNeil%2C+Malcolm+R%3BHula%2C+William+D%3BMikolic%2C+Joseph+M&rft.aulast=Doyle&rft.aufirst=Patrick&rft.date=2003-03-01&rft.volume=17&rft.issue=3&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2003-10-01 N1 - Last updated - 2014-06-17 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - *Aphasia (03400); *Brain Damage (09400); *Diagnostic Tests (18550); *Practitioner Patient Relationship (66830); *Emotions (21600); *Communicative Competence (13650); *Test Validity and Reliability (88800) ER - TY - JOUR T1 - A typology of alcohol use patterns among persons with recent traumatic brain injury or spinal cord injury: implications for treatment matching. AN - 85222837; pmid-12638103 AB - OBJECTIVE: To describe empirically valid and clinically meaningful types of alcohol use among persons with recent traumatic brain or spinal cord injury. DESIGN: Cross-sectional cohort survey. SETTING: Acute inpatient rehabilitation program in a level I trauma center. PARTICIPANTS: A total of 218 (87%) of 250 consecutive initial admissions who met inclusion criteria and completed interviews. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Alcohol and drug use questionnaires, alcohol problem questions, admission toxicology results, readiness to change, and treatment preference questions. RESULTS: Participants were on average 37 years old, 84% were men, and 82% were white. Four types were identified by using k-means cluster analysis based on preinjury alcohol consumption, alcohol problems, and alcohol dependence. Cluster groups differed on extrinsic variables such as drug use, readiness to change, and interest in treatment or in attending Alcoholics Anonymous. The 4 types corresponded to those with a history of (1) alcohol abuse; (2) alcohol dependence; (3) alcohol dependence in remission, partial remission, or relapsed; and (4) normal or nondrinkers. CONCLUSION: More effective care may be possible if clinicians match common patient types to specific interventions such as education, motivational interventions, formal substance abuse treatment, and relapse prevention. JF - Archives of Physical Medicine and Rehabilitation AU - Turner, Aaron P AU - Bombardier, Charles H AU - Rimmele, Carl T AD - Veterans Administration Puget Sound Health Care System Center for Excellence in Substance Abuse Treatment and Education, Seattle, WA, USA. PY - 2003 SP - 358 EP - 364 VL - 84 IS - 3 SN - 0003-9993, 0003-9993 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85222837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=A+typology+of+alcohol+use+patterns+among+persons+with+recent+traumatic+brain+injury+or+spinal+cord+injury%3A+implications+for+treatment+matching.&rft.au=Turner%2C+Aaron+P%3BBombardier%2C+Charles+H%3BRimmele%2C+Carl+T&rft.aulast=Turner&rft.aufirst=Aaron&rft.date=2003-03-01&rft.volume=84&rft.issue=3&rft.spage=358&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Assessment of respiratory symptoms and asthma prevalence in a U.S.-Mexico border region. AN - 75761840; 14535575 AB - The authors studied children who were 10-12 yr of age and who resided in sister cities in a U.S.-Mexico border region to determine the prevalence of asthma and respiratory symptoms. The relationship of symptoms to ambient levels of particulate matter less than 10 microm in diameter (PM10), and to several indoor environmental conditions, was assessed. The study was conducted in the border cities of Ambos Nogales (Nogales, Arizona [United States], and Nogales, Sonora [Mexico]). At the beginning of the 11-wk study, during the autumn of 1996, 631 students and their parents completed baseline questionnaires. While in school, the children completed daily symptom diaries and daily peak expiratory flow maneuvers. PM10 values and daily temperatures were also measured. The authors found that the prevalence of self-reported asthma among 5th-grade students was comparable on both sides of the border (i.e., 7.6% on the Arizona side and 6.9% on the Sonora side). Wheezing was a frequent complaint (29.5-35.6%), as was cough (16.8-29.6%). Smoking in the home was common on both sides of the border, and it was associated with a greater occurrence of self-reported asthma and respiratory complaints. Increased respiratory symptoms were also associated with increased ambient PM10 levels. The prevalence of respiratory symptoms such as wheezing and frequent cough among all children in this study, combined with the limitations inherent in self-reporting, suggest that asthma may actually be more prevalent than has been previously reported. JF - Archives of environmental health AU - Stephen, George A AU - McRill, Cheryl AU - Mack, Maura D AU - O'Rourke, Mary Kay AU - Flood, Timothy J AU - Lebowitz, Michael D AD - Southern Arizona VA Health Care System, University of Arizona, Tucson, Arizona 85723, USA. stephen@med.va.gov Y1 - 2003/03// PY - 2003 DA - March 2003 SP - 156 EP - 162 VL - 58 IS - 3 SN - 0003-9896, 0003-9896 KW - Air Pollutants KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Respiratory Function Tests KW - Respiratory Sounds -- etiology KW - Arizona -- epidemiology KW - Particle Size KW - Humans KW - Child KW - Mexico -- epidemiology KW - Cough -- epidemiology KW - Urban Population KW - Male KW - Female KW - Prevalence KW - Cough -- etiology KW - Asthma -- epidemiology KW - Asthma -- etiology KW - Environmental Exposure KW - Air Pollutants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75761840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+environmental+health&rft.atitle=Assessment+of+respiratory+symptoms+and+asthma+prevalence+in+a+U.S.-Mexico+border+region.&rft.au=Stephen%2C+George+A%3BMcRill%2C+Cheryl%3BMack%2C+Maura+D%3BO%27Rourke%2C+Mary+Kay%3BFlood%2C+Timothy+J%3BLebowitz%2C+Michael+D&rft.aulast=Stephen&rft.aufirst=George&rft.date=2003-03-01&rft.volume=58&rft.issue=3&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=Archives+of+environmental+health&rft.issn=00039896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-10-23 N1 - Date created - 2003-10-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Amifostine and curative intent chemoradiation for compromised cancer patients. AN - 73424366; 12820436 AB - Concurrent chemotherapy and radiation are usually indicated for locally advanced carcinomas such as head and neck and anal malignancies. Because of the toxicity of the treatment, patient selection plays an important role in recommendations to treat with a curative intent. Elderly patients (> 70 years), those with underlying medical conditions or acquired immunological disorders (AIDS) are commonly excluded from combined modality therapy because of their perceived inability to tolerate the aggressive treatment. They may thus be deprived of a potentially curative therapy. In an attempt to improve outcome, we conducted a pilot study using amifostine, a radioprotector, to increase the tolerance of such compromised individuals to treatment. Amifostine (500 mg intravenously) was given during chemotherapy on days 1-5, and days 21-25 of radiation regimen. All patients were able to complete the chemoradiation. Despite the locally advanced stage of the disease, five out of our six patients achieved a complete response (CR). One patient with synchronous primaries had a complete response for the base of tongue cancer and regression of the esophageal cancer, which allowed him to resume oral feeding. All patients achieved improved quality of life. Successful chemoradiation appears to be feasible in patients with advanced stage, age and/or underlying medical conditions when amifostine is integrated in the treatment. JF - Anticancer research AU - Nguyen, Nam P AU - Levinson, Barry AU - Dutta, Suresh AU - Karlsson, Ulf AU - Kelly, Kevin C AU - Dowell, Jonathan AU - Ludin, Adir AU - Sallah, Sabah AD - Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, VA North Texas Health Care System, 4500 S Lancaster Road, Dallas, TX 75216, USA. NamPhong.Nguyen@med.va.gov PY - 2003 SP - 1649 EP - 1656 VL - 23 IS - 2C SN - 0250-7005, 0250-7005 KW - Radiation-Protective Agents KW - 0 KW - Amifostine KW - M487QF2F4V KW - Cisplatin KW - Q20Q21Q62J KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Fluorouracil -- administration & dosage KW - Combined Modality Therapy KW - Aged, 80 and over KW - Humans KW - Aged KW - Pilot Projects KW - Middle Aged KW - Male KW - Cisplatin -- administration & dosage KW - Anus Neoplasms -- radiotherapy KW - Amifostine -- therapeutic use KW - Acquired Immunodeficiency Syndrome -- complications KW - Anus Neoplasms -- drug therapy KW - Radiation-Protective Agents -- therapeutic use KW - Head and Neck Neoplasms -- complications KW - Head and Neck Neoplasms -- radiotherapy KW - Anus Neoplasms -- complications KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Head and Neck Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73424366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+research&rft.atitle=Amifostine+and+curative+intent+chemoradiation+for+compromised+cancer+patients.&rft.au=Nguyen%2C+Nam+P%3BLevinson%2C+Barry%3BDutta%2C+Suresh%3BKarlsson%2C+Ulf%3BKelly%2C+Kevin+C%3BDowell%2C+Jonathan%3BLudin%2C+Adir%3BSallah%2C+Sabah&rft.aulast=Nguyen&rft.aufirst=Nam&rft.date=2003-03-01&rft.volume=23&rft.issue=2C&rft.spage=1649&rft.isbn=&rft.btitle=&rft.title=Anticancer+research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-07-10 N1 - Date created - 2003-06-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adverse drug reactions associated with antipsychotics, antidepressants, and mood stabilizers. AN - 73245680; 12712677 AB - This article on major ADRs associated with psychotropic agents has overviewed major side effects of conventional and novel medications. Nursing interventions that focus on prevention, early identification, accurate diagnosis and appropriate interventions are crucial to treatment outcomes. JF - The Nursing clinics of North America AU - Antai-Otong, Deborah AD - Employee Support Program, Mental Health Outpatient Clinic, VA North Texas Health Care System, 4500 South Lancaster Road, Dallas, TX 75216, USA. Deborah.antai-otong@med.va.gov Y1 - 2003/03// PY - 2003 DA - March 2003 SP - 161 EP - 176 VL - 38 IS - 1 SN - 0029-6465, 0029-6465 KW - Antidepressive Agents KW - 0 KW - Antimanic Agents KW - Antipsychotic Agents KW - Serotonin Uptake Inhibitors KW - Abridged Index Medicus KW - Index Medicus KW - Nursing KW - Neuroleptic Malignant Syndrome -- diagnosis KW - Humans KW - Serotonin Uptake Inhibitors -- adverse effects KW - Antimanic Agents -- adverse effects KW - Antidepressive Agents -- adverse effects KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73245680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Nursing+clinics+of+North+America&rft.atitle=Adverse+drug+reactions+associated+with+antipsychotics%2C+antidepressants%2C+and+mood+stabilizers.&rft.au=Antai-Otong%2C+Deborah&rft.aulast=Antai-Otong&rft.aufirst=Deborah&rft.date=2003-03-01&rft.volume=38&rft.issue=1&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=The+Nursing+clinics+of+North+America&rft.issn=00296465&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-21 N1 - Date created - 2003-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment and outcomes of older patients with alcohol use disorders in community residential programs. AN - 73233239; 12713195 AB - To determine whether older patients with alcohol use disorders receive equitable treatment in community residential facilities. Older male veterans with alcohol use disorders who were treated in 63 community residential facilities (CRFs) were matched with young and middle-aged male veterans in these programs (n = 190 in each age group) on demographic variables and dual-diagnosis status. Patients were assessed at program intake and were followed 1 year and 4 years after treatment entry. Program staff provided information on use of services and on program characteristics. Although they had similar alcohol consumption and dependence symptoms at treatment entry, older patients experienced fewer alcohol-related problems and had fewer symptoms of psychological distress than did young and middle-aged patients. Controlling for initial differences, older patients did at least as well as young and middle-aged patients at both follow-ups. Older, middle-aged and young patients had equivalent treatment involvement in the CRF, participation in continuing outpatient care and involvement in self-help groups. Similar factors predicted better outcomes for older and younger patients, including a longer stay in the CRF, more counseling, involvement in supportive relationships with other residents, continuing outpatient substance abuse care and participation in self-help groups following residential treatment. Both older and younger patients showed similar benefits across varied treatment orientations. Older patients fare at least as well as younger patients in these age-integrated, community-based programs, and they respond in similar ways to treatment experiences and program factors. JF - Journal of studies on alcohol AU - Lemke, Sonne AU - Moos, Rudolf H AD - Center for Health Care Evaluation and Program Evaluation and Resource Center, (152-MPD), Veterans Affairs Palo Alto Health Care System, 795 Willow Road, Menlo Park, California 94025, USA. Sonne.Lemke@med.va.gov Y1 - 2003/03// PY - 2003 DA - March 2003 SP - 219 EP - 226 VL - 64 IS - 2 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Age Factors KW - Prospective Studies KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Residential Treatment KW - Community Mental Health Services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73233239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Treatment+and+outcomes+of+older+patients+with+alcohol+use+disorders+in+community+residential+programs.&rft.au=Lemke%2C+Sonne%3BMoos%2C+Rudolf+H&rft.aulast=Lemke&rft.aufirst=Sonne&rft.date=2003-03-01&rft.volume=64&rft.issue=2&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-20 N1 - Date created - 2003-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Singlet-oxygen generation from A2E. AN - 73179533; 12685649 AB - Singlet-oxygen generation was measured in solutions containing equilibrium mixtures of the retinal lipofuscins, 2-[2, 6-dimethyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)- 1E,3E,5E,7Eoctatetraenyl]-1-(2-hydroxyethyl)-4-[4-methyl-6(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E-hexatrienyl]-pyridinium (A2E) and double bond isomer of A2E (iso-A2E), using steady-state irradiation and using cholesterol as a singlet-oxygen trap. The amount of singlet oxygen generated by equilibrium mixtures of A2E and iso-A2E was compared with that generated by tetraphenylporphine (TPP) under the same conditions. Studies were carried out in ethanol-d6, acetone-d6, 80% cyclohexane-d(12)-20% acetone-d6 (vol/vol) and hexafluorobenzene. Using 420 nm irradiation and assuming a singlet-oxygen quantum yield of 0.60 +/- 0.12 for TPP, the singlet-oxygen quantum yields were 0.8 +/- 0.3 x 10(-3), 1.2 +/- 0.4 x 10(-3), 2 +/- 1 x 10(-3) and 4 + 1 x 10(-3), respectively. In acetone-d6, the quantum yields were smaller at longer wavelengths, with values of 0.3 +/- 0.1 x 10(-3) and 0.4 +/- 0.2 x 10(-3) at 461 and 493 nm, respectively. Singlet-oxygen generation was greatest in solvents with the lowest dielectric constants. In view of the relatively small quantum yields, the contribution of singlet-oxygen generation to the phototoxic properties of A2E and of iso-A2E will require further study. JF - Photochemistry and photobiology AU - Kanofsky, Jeffrey R AU - Sima, Paul D AU - Richter, Christoph AD - Medical Service, Edward Hines Jr., Department of Veterans Affairs Hospital, Hines, IL 60141, USA. jeff.kanofsky@med.va.gov Y1 - 2003/03// PY - 2003 DA - March 2003 SP - 235 EP - 242 VL - 77 IS - 3 SN - 0031-8655, 0031-8655 KW - A2-E (N-retinylidene-N-retinylethanolamine) KW - 0 KW - Pyridinium Compounds KW - Retinoids KW - Singlet Oxygen KW - 17778-80-2 KW - cholesterol hydroperoxide KW - 7J48214Z9H KW - Cholesterol KW - 97C5T2UQ7J KW - Index Medicus KW - Photochemistry KW - Aging -- metabolism KW - Pigment Epithelium of Eye -- metabolism KW - Humans KW - In Vitro Techniques KW - Luminescence KW - Singlet Oxygen -- metabolism KW - Retinoids -- metabolism KW - Retinoids -- toxicity KW - Pyridinium Compounds -- metabolism KW - Cholesterol -- metabolism KW - Pyridinium Compounds -- toxicity KW - Cholesterol -- analogs & derivatives KW - Retinoids -- radiation effects KW - Pyridinium Compounds -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73179533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Singlet-oxygen+generation+from+A2E.&rft.au=Kanofsky%2C+Jeffrey+R%3BSima%2C+Paul+D%3BRichter%2C+Christoph&rft.aulast=Kanofsky&rft.aufirst=Jeffrey&rft.date=2003-03-01&rft.volume=77&rft.issue=3&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-27 N1 - Date created - 2003-04-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Understanding the new and evolving profile of adverse drug effects in schizophrenia. AN - 73176083; 12683265 AB - This article has reviewed the emerging side-effect profiles of second-generation antipsychotic medications. Although these medications have favorable extrapyramidal side-effect profiles, clinicians must be aware of their propensity to cause weight gain, glucose and lipid abnormalities, and cardiac and sexual side effects. If clinicians are proactive about warning patients about these side effects and appropriately monitoring them, further morbidity and mortality may be prevented in this patient population. Initial choices of medication should be made based on the relative side-effect profiles in light of a particular patient's medical status. In the future, new treatments may be developed, with even fewer side effects. JF - The Psychiatric clinics of North America AU - Wirshing, Donna A AU - Pierre, Joseph M AU - Erhart, Stephen M AU - Boyd, Jennifer A AD - Department of Psychiatry, Schizophrenia Treatment Unit, Veterans Administration West Los Angeles Healthcare Center, 11301 Wilshire Boulevard, Building 210, Room 15, Los Angeles, CA 90073, USA. ames@ucla.edu Y1 - 2003/03// PY - 2003 DA - March 2003 SP - 165 EP - 190 VL - 26 IS - 1 SN - 0193-953X, 0193-953X KW - Antipsychotic Agents KW - 0 KW - Prolactin KW - 9002-62-4 KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Weight Gain -- drug effects KW - Long QT Syndrome -- chemically induced KW - Hyperlipidemias -- chemically induced KW - Humans KW - Glucose -- metabolism KW - Diabetes Mellitus -- chemically induced KW - Sexual Dysfunction, Physiological -- chemically induced KW - Male KW - Female KW - Prolactin -- metabolism KW - Schizophrenia -- classification KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73176083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Psychiatric+clinics+of+North+America&rft.atitle=Understanding+the+new+and+evolving+profile+of+adverse+drug+effects+in+schizophrenia.&rft.au=Wirshing%2C+Donna+A%3BPierre%2C+Joseph+M%3BErhart%2C+Stephen+M%3BBoyd%2C+Jennifer+A&rft.aulast=Wirshing&rft.aufirst=Donna&rft.date=2003-03-01&rft.volume=26&rft.issue=1&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=The+Psychiatric+clinics+of+North+America&rft.issn=0193953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-01 N1 - Date created - 2003-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A survey of gun collection and use among three groups of veteran patients admitted to veterans affairs hospital treatment programs. AN - 73154475; 12659354 AB - An important risk factor for suicide is psychiatric illness, but only a limited amount of work has been directed at assessing the use of firearms and other weapons by select psychiatric populations at high risk for violent acts. Patients with combat-related posttraumatic stress disorder (PTSD), patients with schizophrenia, and patients undergoing rehabilitation for substance abuse were asked to complete a weapons-use survey and measures of psychopathology. The PTSD patients surveyed related owning more than four times as many firearms as other subjects and reported significantly higher levels of potentially dangerous firearm-related behaviors than the other psychiatric subjects surveyed. High levels of aggression, impulsive and dangerous weapon use, and ready weapon availability may be significant factors in gun-related violence in the PTSD patient population. Additional prospective research is needed to determine whether gun ownership or certain types of weapon use in this population is associated with future acts of violence. JF - Southern medical journal AU - Freeman, Thomas W AU - Roca, Vincent AU - Kimbrell, Tim AD - Mental Health Service, Central Arkansas Veterans Healthcare System, and the Department of Psychiatry, University of Arkansas School of Medical Sciences, Little Rock, AR, USA. thomas.freeman@med.va.gov Y1 - 2003/03// PY - 2003 DA - March 2003 SP - 240 EP - 243 VL - 96 IS - 3 SN - 0038-4348, 0038-4348 KW - Abridged Index Medicus KW - Index Medicus KW - Analysis of Variance KW - Risk-Taking KW - Hostility KW - Aggression -- psychology KW - Humans KW - Adult KW - Veterans -- psychology KW - Middle Aged KW - Ownership KW - Male KW - Arkansas KW - Combat Disorders -- psychology KW - Firearms KW - Schizophrenic Psychology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Suicide -- psychology KW - Suicide -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73154475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=A+survey+of+gun+collection+and+use+among+three+groups+of+veteran+patients+admitted+to+veterans+affairs+hospital+treatment+programs.&rft.au=Freeman%2C+Thomas+W%3BRoca%2C+Vincent%3BKimbrell%2C+Tim&rft.aulast=Freeman&rft.aufirst=Thomas&rft.date=2003-03-01&rft.volume=96&rft.issue=3&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-10 N1 - Date created - 2003-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Older and younger patients with substance use disorders: outpatient mental health service use and functioning over a 12-month interval. AN - 73148883; 12665080 AB - This observational study compared a nationwide sample of older patients with substance use disorders (n = 3,598; age > 55) with a demographically and diagnostically matched sample of younger patients on initial functioning, subsequent outpatient mental health service use, and 12-month follow-up outcomes. Older patents were initially functioning a well as or better than younger patients according to substance use, psychiatric, family, and legal criteria. The groups received comparable amounts of outpatient mental health care. At a 12-month follow-up, older patients generally had better substance use and functioning outcomes than did younger patients. The findings suggest that older patients with substance use disorders are keeping pace with demographically and diagnostically comparable younger patients in obtaining specialized outpatient mental health services and that they have positive treatment prognoses. JF - Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors AU - Brennan, Penny L AU - Nichol, Aran C AU - Moos, Rudolf H AD - Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA. penny.brennan@med.va.gov Y1 - 2003/03// PY - 2003 DA - March 2003 SP - 42 EP - 48 VL - 17 IS - 1 SN - 0893-164X, 0893-164X KW - Index Medicus KW - United States KW - Analysis of Variance KW - Age Factors KW - Aged, 80 and over KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Community Mental Health Services -- utilization KW - Outcome and Process Assessment (Health Care) KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73148883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+addictive+behaviors+%3A+journal+of+the+Society+of+Psychologists+in+Addictive+Behaviors&rft.atitle=Older+and+younger+patients+with+substance+use+disorders%3A+outpatient+mental+health+service+use+and+functioning+over+a+12-month+interval.&rft.au=Brennan%2C+Penny+L%3BNichol%2C+Aran+C%3BMoos%2C+Rudolf+H&rft.aulast=Brennan&rft.aufirst=Penny&rft.date=2003-03-01&rft.volume=17&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Psychology+of+addictive+behaviors+%3A+journal+of+the+Society+of+Psychologists+in+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-01 N1 - Date created - 2003-03-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Time-dependent interactions of oxidant-sensitive fluoroprobes with inhibitors of cellular metabolism. AN - 73109846; 12649337 AB - We tested three oxidant sensitive fluoroprobes (dihydrorhodamine [DHR], 2',7'-dichlorodihydrofluorescein [H(2)DCF], and dihydroethidium [DHE]) for interactions with three inhibitors of mitochondrial electron transport. DHR, H(2)DCF, and DHE produced large time-dependent increases in fluorescence in a cell-free medium that contained either of the site III inhibitors antimycin (A) and 2-heptyl-4-hydroxy-quinoline-N-oxide but minimal increases in medium that contained another site III inhibitor, myxothiazol (Mx). The interactions between A and each of the fluoroprobes occurred at concentrations of agent/probe that are frequently used in experiments designed to investigate cellular oxidant production. To define more effectively the nature of these agent/probe interactions, we determined the oxygen dependence of the interactions between A and each probe. The A/H(2)DCF and A/DHR interactions either were highly oxygen-dependent or exhibited a small degree of oxygen dependence, respectively, whereas the A/DHE interaction was oxygen-independent. Finally, we determined multiple ways to reduce the impact of the agent/probe interaction on data acquisition. The addition of either fetal bovine serum (10%) or albumin (5%) to the media abolished the A/DHR and A/H(2)DCF interactions. Shifting the excitation wavelength of DHE (from 470 to 530 nm) reduced measurement of the A/DHE interaction while preserving measurement of the intracellular signal. Collectively, these results emphasize the importance of testing for interactions between agents and probes, because these interactions can interfere with the accurate interpretation of experimental results. In addition, the methods presented for circumventing these interactions may be applicable to other experiments in which agent/probe interactions are an obstacle to accurate interpretation of the experimental results. JF - Laboratory investigation; a journal of technical methods and pathology AU - Tollefson, Kirsten E AU - Kroczynski, James AU - Cutaia, Michael V AD - Pulmonary Disease Section, Department of Medicine, Veterans Administration Medical Center, and State University of New York/Downstate Health Sciences Center, Brooklyn, New York 19209-7104, USA. Y1 - 2003/03// PY - 2003 DA - March 2003 SP - 367 EP - 375 VL - 83 IS - 3 SN - 0023-6837, 0023-6837 KW - Fluorescent Dyes KW - 0 KW - Hydroxyquinolines KW - Indicators and Reagents KW - Methacrylates KW - Oxidants KW - Thiazoles KW - antimycin KW - 11118-72-2 KW - 2-(n-heptyl)-4-hydroxyquinoline N-oxide KW - 1FU5S5CG6A KW - Antimycin A KW - 642-15-9 KW - myxothiazol KW - 76706-55-3 KW - Index Medicus KW - Thiazoles -- pharmacology KW - Electron Transport KW - Cells, Cultured KW - Hydroxyquinolines -- pharmacology KW - Humans KW - Time Factors KW - Antimycin A -- pharmacology KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Endothelium, Vascular -- cytology KW - Antimycin A -- analogs & derivatives KW - Oxidants -- chemistry KW - Oxidants -- metabolism KW - Fluorescent Dyes -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73109846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.atitle=Time-dependent+interactions+of+oxidant-sensitive+fluoroprobes+with+inhibitors+of+cellular+metabolism.&rft.au=Tollefson%2C+Kirsten+E%3BKroczynski%2C+James%3BCutaia%2C+Michael+V&rft.aulast=Tollefson&rft.aufirst=Kirsten&rft.date=2003-03-01&rft.volume=83&rft.issue=3&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.issn=00236837&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-08 N1 - Date created - 2003-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Safe patient handling and movement. AN - 73088699; 12626938 JF - The American journal of nursing AU - Nelson, Audrey AU - Owen, Bernice AU - Lloyd, John D AU - Fragala, Guy AU - Matz, Mary W AU - Amato, Margaret AU - Bowers, Judith AU - Moss-Cureton, Susan AU - Ramsey, Glenn AU - Lentz, Karen AD - Patient Safety Center of Inquiry at the Veterans Administration Medical Center, Tampa, FL, USA. audrey.nelson@med.va.gov Y1 - 2003/03// PY - 2003 DA - March 2003 SP - 32 EP - 43; quiz 44 VL - 103 IS - 3 SN - 0002-936X, 0002-936X KW - Abridged Index Medicus KW - Index Medicus KW - Nursing KW - Nursing Assessment KW - Equipment and Supplies KW - Humans KW - Safety KW - Algorithms KW - Occupational Diseases -- prevention & control KW - Occupational Diseases -- etiology KW - Back Injuries -- prevention & control KW - Back Injuries -- etiology KW - Movement KW - Lifting KW - Nursing Care -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73088699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+nursing&rft.atitle=Safe+patient+handling+and+movement.&rft.au=Nelson%2C+Audrey%3BOwen%2C+Bernice%3BLloyd%2C+John+D%3BFragala%2C+Guy%3BMatz%2C+Mary+W%3BAmato%2C+Margaret%3BBowers%2C+Judith%3BMoss-Cureton%2C+Susan%3BRamsey%2C+Glenn%3BLentz%2C+Karen&rft.aulast=Nelson&rft.aufirst=Audrey&rft.date=2003-03-01&rft.volume=103&rft.issue=3&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+nursing&rft.issn=0002936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-10 N1 - Date created - 2003-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Brief motivational feedback improves post-incarceration treatment contact among veterans with substance use disorders. AN - 73059246; 12609701 AB - To test the efficacy of providing brief motivational feedback to increase post-incarceration substance use disorders (SUD) treatment contact. Randomized clinical trial (feedback vs. control) with a 2-month post-incarceration follow-up. Veterans (N = 73) incarcerated in a county jail system who met SUD diagnostic criteria. Baseline assessment included the Addiction Severity Index, the Form-90 assessment of recent alcohol use, and a DSM-IV SUD criteria checklist. The primary outcome was Veterans Administration (VA) appointments. Secondary outcomes were the Addiction Severity Index-Followup and the Treatment Services Review. All participants received baseline assessment. The feedback condition received personalized feedback and encouragement to explore ambivalence about change and treatment in a single interview. Participants receiving feedback were more likely to schedule appointments at a VA addictions clinic within 60 days of their jail release dates (67 vs. 41%; P 50%, limiting power to detect significant differences by self-report. Brief motivational feedback shows promise as a way to link incarcerated individuals to SUD treatment services. Copyright 2002 Elsevier Science Ireland Ltd. JF - Drug and alcohol dependence AU - Davis, Tania M AU - Baer, John S AU - Saxon, Andrew J AU - Kivlahan, Daniel R AD - Center of Excellence in Substance Abuse Treatment and Education, VA Puget Sound Health Care System, Seattle, WA 98108, USA. tania.davis@med.va.gov Y1 - 2003/03/01/ PY - 2003 DA - 2003 Mar 01 SP - 197 EP - 203 VL - 69 IS - 2 SN - 0376-8716, 0376-8716 KW - Index Medicus KW - Severity of Illness Index KW - Office Visits -- statistics & numerical data KW - Feedback, Psychological KW - Humans KW - Middle Aged KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - Motivation KW - Interview, Psychological -- methods KW - Veterans -- psychology KW - Prisoners -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73059246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Brief+motivational+feedback+improves+post-incarceration+treatment+contact+among+veterans+with+substance+use+disorders.&rft.au=Davis%2C+Tania+M%3BBaer%2C+John+S%3BSaxon%2C+Andrew+J%3BKivlahan%2C+Daniel+R&rft.aulast=Davis&rft.aufirst=Tania&rft.date=2003-03-01&rft.volume=69&rft.issue=2&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-07-09 N1 - Date created - 2003-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A National Survey of the Oral Health Status of Homeless Veterans AN - 21128268; 11162662 AB - Objectives: This study reports results from a survey designed to (1) assess the oral health needs of a national sample of homeless veterans and (2) compare the dental needs of homeless veterans participating in VA-sponsored rehabilitation programs with domiciled veterans in VA substance addiction programs. Methods:Homeless veterans enrolled in a nationwide rehabilitation program (n=1,152) completed a survey including questions concerning patients' perceptions of their oral health, dental service needs and use, and alcohol and tobacco use. A sample of these veterans (n=281) subsequently received dental exams. A comparison group of domiciled veterans enrolled in VA substance abuse programs (n=339) completed a similar survey. A sample of these veterans (n=150) also received dental exams. Results: Sociodemographic variables, patient-reported oral health information and risk behaviors, and findings from dental exams described two remarkably similar populations. Conclusions: As expected, the homeless veterans exhibited poor oral health, but it was not different from domiciled veterans enrolled in substance addiction programs. Lifestyle choices, such as heavy drinking and smoking, may contribute more to poor oral health than living conditions. Manuscript received: 2/12/01; returned to authors for revision: 5/11/01; final version accepted for publication: 1/28/02. JF - Journal of Public Health Dentistry AU - Gibson, Gretchen AU - Rosenheck, Robert AU - Tullner, John B AU - Grimes, Rebecca M AU - Seibyl, Catherine L AU - Rivera-Torres, Angel AU - Goodman, Harold S AU - Nunn, Martha E Y1 - 2003/03// PY - 2003 DA - Mar 2003 SP - 30 EP - 37 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 63 IS - 1 SN - 0022-4006, 0022-4006 KW - Health & Safety Science Abstracts KW - Alcohol KW - living conditions KW - substance abuse KW - Smoking KW - dentistry KW - Perception KW - Tobacco KW - homelessness KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21128268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health+Dentistry&rft.atitle=A+National+Survey+of+the+Oral+Health+Status+of+Homeless+Veterans&rft.au=Gibson%2C+Gretchen%3BRosenheck%2C+Robert%3BTullner%2C+John+B%3BGrimes%2C+Rebecca+M%3BSeibyl%2C+Catherine+L%3BRivera-Torres%2C+Angel%3BGoodman%2C+Harold+S%3BNunn%2C+Martha+E&rft.aulast=Gibson&rft.aufirst=Gretchen&rft.date=2003-03-01&rft.volume=63&rft.issue=1&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health+Dentistry&rft.issn=00224006&rft_id=info:doi/10.1111%2Fj.1752-7325.2003.tb03471.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - homelessness; living conditions; Smoking; Alcohol; Tobacco; Perception; dentistry; substance abuse DO - http://dx.doi.org/10.1111/j.1752-7325.2003.tb03471.x ER - TY - JOUR T1 - ISOLATION OF MURINE AORTIC ENDOTHELIAL CELLS IN CULTURE AND THE EFFECTS OF SEX STEROIDS ON THEIR GROWTH AN - 19332738; 8696266 AB - The lack of commercially available primary murine endothelial cells prompted us to isolate and cultivate this cell type. We report here the effect of sex steroids on the in vitro growth of murine aortic endothelial cells. Murine aortic endothelial cells were isolated by a combination of explant outgrowth from aortic rings and enzymatic digestion. The endothelial nature of the cells was verified by uptake of acylated low-density lipoprotein and positive staining for CD-31. Murine aortic endothelial cell growth is stimulated by physiological concentrations of estrogen. Progesterone, when given simultaneously with estrogen, inhibited the stimulatory growth effect of estrogen. Murine aortic endothelial cells grown in vitro continue to express messenger ribonucleic acid for proteins related to endothelial growth. These include vascular endothelial growth factor, its receptors Flt-1 and Flk-1, and the angiogenesis-associated transcription factor, Ets-1. JF - In Vitro Cellular & Developmental Biology - Animal AU - Lincoln, David W AU - Larsen, Ann M AU - Phillips, Patricia G AU - Bove, Kathleen AD - Research Service, Stratton VA Medical Center, Albany, New York 12208 (D. W. L., P. G. P., K. B.), Albany Research Institute, Inc., Albany, New York 12208 (A. M. L.), and Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208 (P. G. P.), kathleen.bove@med.va.gov Y1 - 2003/03// PY - 2003 DA - Mar 2003 SP - 140 EP - 145 PB - Allen Press, Inc., 810 East Tenth St. VL - 39 IS - 3 SN - 1071-2690, 1071-2690 KW - Biotechnology and Bioengineering Abstracts KW - mouse KW - estrogen KW - VEGF KW - angiogenesis KW - Endothelial cells KW - Vascular endothelial growth factor KW - Estrogens KW - Progesterone KW - Aorta KW - Transcription factors KW - Lipoproteins KW - Cell culture KW - Steroid hormones KW - Vascular endothelial growth factor receptor 2 KW - Explants KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19332738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.atitle=ISOLATION+OF+MURINE+AORTIC+ENDOTHELIAL+CELLS+IN+CULTURE+AND+THE+EFFECTS+OF+SEX+STEROIDS+ON+THEIR+GROWTH&rft.au=Lincoln%2C+David+W%3BLarsen%2C+Ann+M%3BPhillips%2C+Patricia+G%3BBove%2C+Kathleen&rft.aulast=Lincoln&rft.aufirst=David&rft.date=2003-03-01&rft.volume=39&rft.issue=3&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.issn=10712690&rft_id=info:doi/10.1290%2F1543-706X%282003%290392.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Vascular endothelial growth factor; Endothelial cells; Estrogens; Progesterone; Transcription factors; Aorta; Lipoproteins; Cell culture; Vascular endothelial growth factor receptor 2; Steroid hormones; Explants DO - http://dx.doi.org/10.1290/1543-706X(2003)039<0140:IOMAEC>2.0.CO;2 ER - TY - JOUR T1 - Anatomy and Biomechanics of the Elbow Joint AN - 18793040; 5651502 AB - The elbow joint is a complex structure that provides an important function as the mechanical link in the upper extremity between the hand, wrist and the shoulder. The elbow's functions include positioning the hand in space for fine movements, powerful grasping and serving as a fulcrum for the forearm. Loss of elbow function can severely affect activities of daily living. It is important to recognize the unique anatomy of the elbow, including the bony geometry, articulation, and soft tissue structures. The biomechanics of the elbow joint can be divided into kinematics, stabilizing structures in elbow stability, and force transmission through the elbow joint. The passive and active stabilizers provide biomechanical stability in the elbow joint. The passive stabilizers include the bony articular geometry and the soft tissue stabilizers. The active stabilizers are the muscles that provide joint compressive forces and function. Knowledge of both the anatomy and biomechanics is essential for proper treatment of elbow disorders. JF - Sports Medicine and Arthroscopy Review AU - Fornalski, S AU - Gupta, R AU - Lee, T Q AD - Orthopaedic Biomechanics Laboratory VA Long Beach Healthcare System (09/151), 5901 East 7th Street, Long Beach, California, 90822, USA, tqlee@med.va.gov Y1 - 2003/03// PY - 2003 DA - Mar 2003 SP - 1 EP - 9 VL - 11 IS - 1 SN - 1062-8592, 1062-8592 KW - Physical Education Index KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18793040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sports+Medicine+and+Arthroscopy+Review&rft.atitle=Anatomy+and+Biomechanics+of+the+Elbow+Joint&rft.au=Fornalski%2C+S%3BGupta%2C+R%3BLee%2C+T+Q&rft.aulast=Fornalski&rft.aufirst=S&rft.date=2003-03-01&rft.volume=11&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Sports+Medicine+and+Arthroscopy+Review&rft.issn=10628592&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Use of the Microbial Growth Curve in Postantibiotic Effect Studies of Legionella pneumophila AN - 18715315; 5591602 AB - Using the standard Craig and Gudmundsson method (W. A. Craig and S. Gudmundsson, p. 296-329, in V. Lorian, ed., Antibiotics in Laboratory Medicine, 1996) as a guideline for determination of postantibiotic effects (PAE), we studied a large series of growth curves for two strains of Legionella pneumophila. We found that the intensity of the PAE was best determined by using a statistically fitted line over hours 3 to 9 following antibiotic removal. We further determined the PAE duration by using a series of observations of the assay interval from hours 3 to 24. We determined that inoculum reduction was not necessarily the only predictor of the PAE but that the PAE was subject to the type and dose of the drug used in the study. In addition, there was a variation between strains. Only levofloxacin at five and ten times the minimum inhibitory concentration (MIC) resulted in a PAE duration of 4 to 10 h for both strains of L. pneumophila tested. Ciprofloxacin at five and Ten times the MIC and azithromycin at Ten times the MIC caused a PAE for one strain only. No PAE could be demonstrated for either strain with erythromycin or doxycycline. Using the presently described method of measuring PAE for L. pneumophila, we were able to detect differences in PAE which were dependent upon the L. pneumophila strain, the antibiotic tested, and the antibiotic concentration. We suggest the use of mathematically fitted curves for comparison of bacterial growth in order to measure PAE for L. pneumophila. JF - Antimicrobial Agents & Chemotherapy AU - Smith, R P AU - Baltch, AL AU - Michelsen, P B AU - Ritz, W J AU - Alteri, R AD - Infectious Disease Research (111D), Stratton VA Medical Center, 113 Holland Ave., Albany, NY 12208, Aldona.Baltch@med.va.gov Y1 - 2003/03// PY - 2003 DA - Mar 2003 SP - 1081 EP - 1087 VL - 47 IS - 3 SN - 0066-4804, 0066-4804 KW - post-antibiotic effect KW - Microbiology Abstracts B: Bacteriology KW - J 02783:Antibiotics: General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18715315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Use+of+the+Microbial+Growth+Curve+in+Postantibiotic+Effect+Studies+of+Legionella+pneumophila&rft.au=Smith%2C+R+P%3BBaltch%2C+AL%3BMichelsen%2C+P+B%3BRitz%2C+W+J%3BAlteri%2C+R&rft.aulast=Smith&rft.aufirst=R&rft.date=2003-03-01&rft.volume=47&rft.issue=3&rft.spage=1081&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.47.3.1081-1087.2003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1128/AAC.47.3.1081-1087.2003 ER - TY - JOUR T1 - PoleStriding Exercise and Vitamin E for Management of Peripheral Vascular Disease AN - 18707943; 5599478 AB - Purpose: The purpose of this investigation was to evaluate the efficacy of PoleStriding exercise (a form of walking that uses muscles of the upper and lower body in a continuous movement similar to cross-country skiing) and vitamin E ( alpha -tocopherol) to improve walking ability and perceived quality of life (QOL) of patients with claudication pain secondary to peripheral arterial disease (PAD). Methods: Fifty-two subjects were randomized into four groups: PoleStriding with vitamin E (N = 13), PoleStriding with placebo (N = 14), vitamin E without exercise (N = 13), and placebo without exercise (N = 12). The dose of vitamin E was 400 IU daily. Only the PoleStriding with vitamin E and PoleStriding with placebo groups received PoleStriding instruction and training. Assignment to vitamin E or placebo was double blind. Subjects trained three times weekly for 30-45 min (rest time excluded). Individuals in vitamin E and placebo groups came to the laboratory biweekly for ankle blood-pressure measurements. Results: Results of this randomized clinical trial provide strong evidence that PoleStriding significantly (P < 0.001) improved exercise tolerance on the constant work-rate and incremental treadmill tests. Ratings of perceived claudication pain were significantly less after the PoleStriding training program (P = 0.02). In contrast, vitamin E did not have a statistically significant effect on the subjects' ratings of perceived leg pain (P = 0.35) or treadmill walking duration (P = 0.36). Perceived distance and walking speed (Walking Impairment Questionnaire) and perceived physical function (Rand Short Form-36) improved in the PoleStriding trained group only (P < 0.001, 0.022 and 0.003, respectively). Conclusion: PoleStriding effectively improved the exercise tolerance and perceived QOL of patients with PAD. Little additional benefit to exercise capacity was realized from vitamin E supplementation. JF - Medicine & Science in Sports & Exercise AU - Collins, E G AU - Langbein, W E AU - Orebaugh, C AU - Bammert, C AU - Hanson, K AU - Reda, D AU - Edwards, L C AU - Littooy, F N AD - Research & Development (151), Edward Hines Jr. VA Hospital, Hines, IL 60141, USA, eileen.collins@med.va.gov Y1 - 2003/03// PY - 2003 DA - Mar 2003 SP - 384 EP - 393 VL - 35 IS - 3 SN - 0195-9131, 0195-9131 KW - Physical Education Index KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18707943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicine+%26+Science+in+Sports+%26+Exercise&rft.atitle=PoleStriding+Exercise+and+Vitamin+E+for+Management+of+Peripheral+Vascular+Disease&rft.au=Collins%2C+E+G%3BLangbein%2C+W+E%3BOrebaugh%2C+C%3BBammert%2C+C%3BHanson%2C+K%3BReda%2C+D%3BEdwards%2C+L+C%3BLittooy%2C+F+N&rft.aulast=Collins&rft.aufirst=E&rft.date=2003-03-01&rft.volume=35&rft.issue=3&rft.spage=384&rft.isbn=&rft.btitle=&rft.title=Medicine+%26+Science+in+Sports+%26+Exercise&rft.issn=01959131&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Blue cone electroretinogram amplitudes are related to dopamine function in cocaine-dependent patients. AN - 73055991; 12606020 AB - The objective of the study was to examine the relationship between an index of central dopamine function and electroretinographic (ERG) blue cone amplitudes in cocaine-dependent patients. Thus, 17 recently abstinent cocaine-dependent patients had an ERG performed. They also had a lumbar puncture for determination of cerebrospinal (CSF) concentrations of the dopamine metabolite homovanillic acid (HVA). It was found that patients who had reduced ERG blue cone b-wave amplitudes (<0.5 microV) had significantly lower concentrations of CSF HVA than patients who had ERG blue cone b-wave amplitudes greater than 0.5 microV. There was also a significant positive correlation between ERG blue cone amplitudes and CSF HVA concentrations. These results suggest the possibility that ERG blue cone amplitudes may be a neurobiologic marker related to central dopamine function in cocaine-dependent patients. Copyright 2002 Elsevier Science Ireland Ltd. JF - Psychiatry research AU - Roy, Alec AU - Roy, Monique AU - Berman, Jeffrey AU - Gonzalez, Bienvenido AD - Psychiatry Service (116A), Department of Veterans Affairs, New Jersey Healthcare System, 385 Tremont Avenue, East Orange, NJ 07018, USA. Alec.Roy@med.va.gov Y1 - 2003/02/15/ PY - 2003 DA - 2003 Feb 15 SP - 191 EP - 195 VL - 117 IS - 2 SN - 0165-1781, 0165-1781 KW - Dopamine KW - VTD58H1Z2X KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Homovanillic Acid -- cerebrospinal fluid KW - Humans KW - Electroretinography -- instrumentation KW - Adult KW - Male KW - Cocaine-Related Disorders -- cerebrospinal fluid KW - Dopamine -- physiology KW - Cocaine-Related Disorders -- physiopathology KW - Dopamine -- cerebrospinal fluid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73055991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Blue+cone+electroretinogram+amplitudes+are+related+to+dopamine+function+in+cocaine-dependent+patients.&rft.au=Roy%2C+Alec%3BRoy%2C+Monique%3BBerman%2C+Jeffrey%3BGonzalez%2C+Bienvenido&rft.aulast=Roy&rft.aufirst=Alec&rft.date=2003-02-15&rft.volume=117&rft.issue=2&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-07-01 N1 - Date created - 2003-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Physiologic effects of open and closed tracheostomy tubes on the pharyngeal swallow. AN - 85399454; pmid-12597287 AB - Studies linking aspiration and dysphagia to an open tracheostomy tube exemplify the possibility that the larynx may have an influence on oropharyngeal swallow function. Experiments addressing the effects of tracheostomy tube occlusion during the swallow have looked at the presence and severity of aspiration, but few have included measurements that capture the changes in swallowing physiology. Also, hypotheses for the importance of near-normal subglottic air pressure during the swallow have not been offered to date. As such, the aim of this study was to compare the depth of laryngeal penetration, bolus speed, and duration of pharyngeal muscle contraction during the swallow in individuals with tracheostomy tubes while their tubes were open and closed. The results of this series of experiments indicate that within the same tracheostomized patient, pharyngeal swallowing physiology is measurably different in the absence of subglottic air pressure (open tube) as compared to the closed tube condition. JF - The Annals of otology, rhinology, and laryngology AU - Gross, Roxann Diez AU - Mahlmann, Jeanne AU - Grayhack, Judith P AD - Department of Audiology and Speech Pathology, Veterans Administration Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240, USA. Y1 - 2003/02// PY - 2003 DA - Feb 2003 SP - 143 EP - 152 VL - 112 IS - 2 SN - 0003-4894, 0003-4894 KW - National Library of Medicine KW - Aged KW - Air Pressure KW - Biomechanics KW - *Deglutition: physiology KW - Deglutition Disorders: etiology KW - *Deglutition Disorders: physiopathology KW - Equipment Failure KW - Fluoroscopy KW - Glottis: physiology KW - Glottis: physiopathology KW - Humans KW - *Inhalation: physiology KW - Male KW - Mechanoreceptors: physiology KW - Mechanoreceptors: physiopathology KW - Middle Aged KW - Muscle Contraction: physiology KW - Observer Variation KW - *Oropharynx: physiology KW - Oropharynx: physiopathology KW - Pharyngeal Muscles: physiology KW - Pharyngeal Muscles: physiopathology KW - Time Factors KW - *Tracheostomy: adverse effects KW - Tracheostomy: instrumentation KW - Videotape Recording UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85399454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.atitle=Physiologic+effects+of+open+and+closed+tracheostomy+tubes+on+the+pharyngeal+swallow.&rft.au=Gross%2C+Roxann+Diez%3BMahlmann%2C+Jeanne%3BGrayhack%2C+Judith+P&rft.aulast=Gross&rft.aufirst=Roxann&rft.date=2003-02-01&rft.volume=112&rft.issue=2&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.issn=00034894&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Depression after traumatic brain injury: a National Institute on Disability and Rehabilitation Research Model Systems multicenter investigation. AN - 85222836; pmid-12601647 AB - OBJECTIVE: To identify the frequency and manifestations of depression after traumatic brain injury (TBI) and the factors that contribute to developing this mood disorder. DESIGN: A prospective, nationwide, multicenter study; 17 centers supplied data from medical records and patient responses on a standardized criterion instrument. SETTING: Traumatic Brain Injury Model Systems programs. PARTICIPANTS: A demographically diverse sample of 666 outpatients with TBI was evaluated 10 to 126 months after injury. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Depressive symptoms were characterized with the Neurobehavioral Functioning Inventory by using the Diagnostic and Statistical Manual of Mental Disorders (4th ed; DSM-IV) diagnostic framework. Analysis of variance and Pearson correlations were used to identify factors that were significantly related to depression. RESULTS: Fatigue (29%), distractibility (28%), anger or irritability (28%), and rumination (25%) were the most commonly cited depressive symptoms in the sample. Twenty-seven percent of patients with TBI met the prerequisite number (>/=5) of criterion A symptoms for a DSM-IV diagnosis of major depressive disorder. Feeling hopeless, feeling worthless, and difficulty enjoying activities were the 3 symptoms that most differentiated depressed from nondepressed patients. Patients who were unemployed at the time of injury and who were impoverished were significantly more likely to report DSM-IV criterion A symptoms than patients who were employed, were students, or were retired due to age. Time after injury, injury severity, and postinjury marital status were not significantly related to depression. CONCLUSIONS: Patients with TBI are at great risk for developing depressive symptoms. Findings provide empirical support for the inclusion of depression evaluation and treatment protocols in brain injury programs. Unemployment and poverty may be substantial risk factors for the development of depressive symptoms. Future research should develop biopsychosocial predictive models to identify high-risk patients and examine the efficacy of treatment interventions. JF - Archives of Physical Medicine and Rehabilitation AU - Seel, Ronald T AU - Kreutzer, Jeffrey S AU - Rosenthal, Mitchell AU - Hammond, Flora M AU - Corrigan, John D AU - Black Kertia AD - Defense and Veterans Brain Injury Center, McGuire Veterans Administration Medical Center, Richmond, VA, USA. PY - 2003 SP - 177 EP - 184 VL - 84 IS - 2 SN - 0003-9993, 0003-9993 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85222836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Physical+Medicine+and+Rehabilitation&rft.atitle=Depression+after+traumatic+brain+injury%3A+a+National+Institute+on+Disability+and+Rehabilitation+Research+Model+Systems+multicenter+investigation.&rft.au=Seel%2C+Ronald+T%3BKreutzer%2C+Jeffrey+S%3BRosenthal%2C+Mitchell%3BHammond%2C+Flora+M%3BCorrigan%2C+John+D%3BBlack+Kertia&rft.aulast=Seel&rft.aufirst=Ronald&rft.date=2003-02-01&rft.volume=84&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Archives+of+Physical+Medicine+and+Rehabilitation&rft.issn=00039993&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Somatic dysfunction during carisoprodol cessation: evidence for a carisoprodol withdrawal syndrome. AN - 73074673; 12622352 AB - Carisoprodol is a commonly used skeletal muscle relaxant with potential for abuse because of its active metabolite, meprobamate, and several reports have suggested that patients abruptly stopping intake of carisoprodol may have a withdrawal syndrome. The authors studied changes in the occurrence of somatic dysfunctions in five patients during an 8-day period following discontinuation from large doses of carisoprodol. Results showed that the number of somatic dysfunctions changed significantly during the withdrawal period. Each patient had an increase in the number of somatic dysfunctions during the first 3 days after cessation of carisoprodol with return to at or near baseline by the eighth day. This was reflected statistically in a significant-within-subjects effect for time. Results of supplemental analyses revealed a significant component of the effect and a trend for the quadratic component to be significant. Increases in the number of somatic dysfunctions during carisoprodol discontinuation support the existence of a carisoprodol withdrawal syndrome. JF - The Journal of the American Osteopathic Association AU - Reeves, Roy R AU - Parker, Jefferson D AD - G.V. (Sonny) Montgomery VA Medical Center and University of Mississippi, Jackson 39216, USA. roy.reeves@med.va.gov Y1 - 2003/02// PY - 2003 DA - February 2003 SP - 75 EP - 80 VL - 103 IS - 2 SN - 0098-6151, 0098-6151 KW - Muscle Relaxants, Central KW - 0 KW - Carisoprodol KW - 21925K482H KW - Index Medicus KW - Humans KW - Adult KW - Male KW - Female KW - Carisoprodol -- adverse effects KW - Substance Withdrawal Syndrome -- physiopathology KW - Somatosensory Disorders -- physiopathology KW - Somatosensory Disorders -- chemically induced KW - Muscle Relaxants, Central -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73074673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+American+Osteopathic+Association&rft.atitle=Somatic+dysfunction+during+carisoprodol+cessation%3A+evidence+for+a+carisoprodol+withdrawal+syndrome.&rft.au=Reeves%2C+Roy+R%3BParker%2C+Jefferson+D&rft.aulast=Reeves&rft.aufirst=Roy&rft.date=2003-02-01&rft.volume=103&rft.issue=2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+American+Osteopathic+Association&rft.issn=00986151&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-04 N1 - Date created - 2003-03-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reference values are de facto regulatory limits for patient exposures. For the proposition. AN - 73057368; 12607845 JF - Medical physics AU - Moore, Mary E AD - Philadelphia VA Medical Center, Radiation Safety Office, Philadelphia, Pennsylvania 19104, USA. MaryE.Moore@med.va.gov Y1 - 2003/02// PY - 2003 DA - February 2003 SP - 273 EP - 274 VL - 30 IS - 2 SN - 0094-2405, 0094-2405 KW - Index Medicus KW - Reference Values KW - Government Regulation KW - Maximum Allowable Concentration KW - Humans KW - Radiation Dosage KW - Radiation Monitoring -- standards KW - Reference Standards KW - Safety -- standards KW - Radiation Protection -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73057368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+physics&rft.atitle=Reference+values+are+de+facto+regulatory+limits+for+patient+exposures.+For+the+proposition.&rft.au=Moore%2C+Mary+E&rft.aulast=Moore&rft.aufirst=Mary&rft.date=2003-02-01&rft.volume=30&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Medical+physics&rft.issn=00942405&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-21 N1 - Date created - 2003-02-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Med Phys. 2003 Feb;30(2):274-5 [12607846] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diminished anticoagulant effects of warfarin with concomitant mercaptopurine therapy. AN - 73018322; 12587816 AB - The drug interaction between mercaptopurine and warfarin is documented, but case reports of the existence or magnitude of this interaction are rare. An increased warfarin dosage was required for a patient receiving 12-week cycles of mercaptopurine for acute promyelocytic leukemia. At the start of mercaptopurine therapy, an upward titration of 25% beyond the warfarin maintenance dosage was required to achieve a therapeutic international normalized ratio. When a cycle of mercaptopurine was completed, a sharp reduction in warfarin dosage was required. The mechanism behind this interaction is unclear. Mercaptopurine may inhibit gastrointestinal absorption of warfarin, or it may induce hepatic enzymes that metabolize the anticoagulant. With dramatic changes in warfarin or anticoagulant requirements, practitioners should be aware of potential thromboembolic sequelae or bleeding complications when these agents are prescribed concomitantly. Frequent monitoring and careful dosage titration are warranted during concomitant administration. JF - Pharmacotherapy AU - Martin, Leigh Ann AU - Mehta, Sanjay D AD - Department of Veterans Affairs Medical Center, Anticoagulation Clinic, Louisville, Kentucky 40206-1499, USA. martin.leigh_a@louisville.med.va.gov Y1 - 2003/02// PY - 2003 DA - February 2003 SP - 260 EP - 264 VL - 23 IS - 2 SN - 0277-0008, 0277-0008 KW - Anticoagulants KW - 0 KW - Antimetabolites, Antineoplastic KW - Warfarin KW - 5Q7ZVV76EI KW - 6-Mercaptopurine KW - E7WED276I5 KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Interactions KW - Aged, 80 and over KW - Humans KW - Drug Monitoring KW - Aged KW - Male KW - Antimetabolites, Antineoplastic -- administration & dosage KW - Leukemia, Promyelocytic, Acute -- drug therapy KW - Antimetabolites, Antineoplastic -- adverse effects KW - Anticoagulants -- adverse effects KW - Warfarin -- adverse effects KW - Warfarin -- administration & dosage KW - 6-Mercaptopurine -- administration & dosage KW - 6-Mercaptopurine -- adverse effects KW - Anticoagulants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73018322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Diminished+anticoagulant+effects+of+warfarin+with+concomitant+mercaptopurine+therapy.&rft.au=Martin%2C+Leigh+Ann%3BMehta%2C+Sanjay+D&rft.aulast=Martin&rft.aufirst=Leigh&rft.date=2003-02-01&rft.volume=23&rft.issue=2&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-23 N1 - Date created - 2003-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Concurrent interferon-alpha and radiation for head and neck melanoma. AN - 72997469; 12569287 AB - Melanoma cells are resistant to radiation in part due to their capacity to repair sublethal damage. A large fraction dose is therefore often utilized. However, if the tumour is located close to critical structures with modest tolerance, high fraction doses increase the risk for late complications compared with standard fractionation, but using the latter alone risks the desired outcome. Concurrent systemic biotherapy with standard radiation fractions may therefore represent an acceptable compromise. The outcome of concurrent systemic interferon-alpha (IFNalpha) and radiation in three patients with head and neck melanoma was evaluated. Standard radiation fractions were used because of the radiosensitizing properties of IFNalpha. Acute toxicity was significant and required treatment interruptions. However, all side effects subsided following treatment. All three patients achieved local control at follow-up periods of 24, 18 and 19 months, respectively. One patient developed widespread distant metastases. The combination of IFNalpha with radiation is considered feasible in terms of outcome and should be investigated with a larger cohort of patients. Toxicity is significant, and the addition of radioprotectors could be desirable. JF - Melanoma research AU - Nguyen, N P AU - Levinson, B AU - Dutta, S AU - Karlsson, U AU - Alfieri, A AU - Childress, C AU - Sallah, S AD - Department of Radiation Oncology and Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75216, USA. NamPhong.Nguyen@med.va.gov Y1 - 2003/02// PY - 2003 DA - February 2003 SP - 67 EP - 71 VL - 13 IS - 1 SN - 0960-8931, 0960-8931 KW - Antineoplastic Agents KW - 0 KW - Interferon-alpha KW - Index Medicus KW - Dose Fractionation KW - Combined Modality Therapy KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Interferon-alpha -- therapeutic use KW - Melanoma -- pathology KW - Melanoma -- drug therapy KW - Head and Neck Neoplasms -- radiotherapy KW - Head and Neck Neoplasms -- pathology KW - Melanoma -- radiotherapy KW - Antineoplastic Agents -- therapeutic use KW - Head and Neck Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72997469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Melanoma+research&rft.atitle=Concurrent+interferon-alpha+and+radiation+for+head+and+neck+melanoma.&rft.au=Nguyen%2C+N+P%3BLevinson%2C+B%3BDutta%2C+S%3BKarlsson%2C+U%3BAlfieri%2C+A%3BChildress%2C+C%3BSallah%2C+S&rft.aulast=Nguyen&rft.aufirst=N&rft.date=2003-02-01&rft.volume=13&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Melanoma+research&rft.issn=09608931&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-09-25 N1 - Date created - 2003-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Non-small cell lung cancer-derived soluble mediators enhance apoptosis in activated T lymphocytes through an I kappa B kinase-dependent mechanism. AN - 72997340; 12566308 AB - T lymphocyte survival is critical for the development and maintenance of an effective host antitumor immune response; however, the tumor environment can negatively impact T-cell survival. Lymphocytes exposed to tumor supernatants (TSNs) were evaluated for apoptosis after mitogen stimulation. TSN was observed to significantly enhance phorbol 12-myristate 13-acetate/ionomycin- and anti-CD3-stimulated lymphocyte apoptosis. Enhanced lymphocyte apoptosis was associated with an impairment of nuclear factor kappa B nuclear translocation and diminished I kappa B alpha degradation. In lymphocytes stimulated after exposure to TSNs, cytoplasmic I kappa B alpha persisted as a result of alterations in I kappa B kinase (IKK) activity. Accordingly, although there were no apparent differences in IKK component concentrations, lymphocytes preexposed to TSNs exhibited markedly reduced IKK activity. We conclude that non-small cell lung cancer-derived soluble factors promote apoptosis in activated lymphocytes by an IKK-dependent pathway. JF - Cancer research AU - Batra, Raj K AU - Lin, Ying AU - Sharma, Sherven AU - Dohadwala, Mariam AU - Luo, Jie AU - Pold, Mehis AU - Dubinett, Steven M AD - Department of Medicine and The Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, University of California at Los Angeles and Veterans Administration-Greater Los Angeles Health Care System, Los Angeles, California 90095, USA. Y1 - 2003/02/01/ PY - 2003 DA - 2003 Feb 01 SP - 642 EP - 646 VL - 63 IS - 3 SN - 0008-5472, 0008-5472 KW - Antigens, CD3 KW - 0 KW - I kappa B beta protein KW - I-kappa B Proteins KW - NF-kappa B KW - Ionomycin KW - 56092-81-0 KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - CHUK protein, human KW - EC 2.7.11.10 KW - I-kappa B Kinase KW - IKBKB protein, human KW - IKBKE protein, human KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Adenocarcinoma -- metabolism KW - I-kappa B Proteins -- immunology KW - Humans KW - I-kappa B Proteins -- metabolism KW - NF-kappa B -- immunology KW - Adenocarcinoma -- immunology KW - Ionomycin -- pharmacology KW - Adenocarcinoma -- pathology KW - Adenocarcinoma -- enzymology KW - Antigens, CD3 -- immunology KW - Jurkat Cells -- pathology KW - Jurkat Cells -- enzymology KW - Jurkat Cells -- immunology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - NF-kappa B -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- metabolism KW - Lung Neoplasms -- enzymology KW - Protein-Serine-Threonine Kinases -- metabolism KW - Lung Neoplasms -- immunology KW - Apoptosis -- immunology KW - Carcinoma, Non-Small-Cell Lung -- immunology KW - Protein-Serine-Threonine Kinases -- immunology KW - T-Lymphocytes -- pathology KW - T-Lymphocytes -- enzymology KW - Carcinoma, Non-Small-Cell Lung -- pathology KW - Carcinoma, Non-Small-Cell Lung -- enzymology KW - T-Lymphocytes -- immunology KW - Lung Neoplasms -- metabolism KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72997340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Non-small+cell+lung+cancer-derived+soluble+mediators+enhance+apoptosis+in+activated+T+lymphocytes+through+an+I+kappa+B+kinase-dependent+mechanism.&rft.au=Batra%2C+Raj+K%3BLin%2C+Ying%3BSharma%2C+Sherven%3BDohadwala%2C+Mariam%3BLuo%2C+Jie%3BPold%2C+Mehis%3BDubinett%2C+Steven+M&rft.aulast=Batra&rft.aufirst=Raj&rft.date=2003-02-01&rft.volume=63&rft.issue=3&rft.spage=642&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-07 N1 - Date created - 2003-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Data and safety monitoring board issues raised in the VA Status Epilepticus Study. AN - 72988087; 12559644 AB - The Department of Veteran Affairs Status Epilepticus Cooperative Study was a randomized, multicenter clinical trial testing four intravenous drug regimens (lorazepam, phenobarbital, phenytoin and diazepam followed by phenytoin) to treat generalized convulsive status epilepticus. During the course of the study, two problems emerged that the study's data and safety monitoring board (DSMB) was required to address: poor recruitment and an unexpected difference in 30-day mortality between treatment groups. By the first annual DSMB meeting, recruitment was only 25.6% of expected. The DSMB recommended placing the study on probation and replacing poorly performing sites. At their second annual meeting, the DSMB recommended approval of proposed changes to the study design contingent on the study leadership removing nonproductive sites. These changes were a 2-year increase in the recruitment period and a change in study design that decreased required sample size. Nonproductive centers were terminated and the approved changes allowed the study to be successfully completed. At the second annual DSMB meeting, an unexpected doubling of mortality rates between drug groups was observed. Although not statistically significant, the finding raised serious concerns for patient safety. The DSMB recommended instituting monthly reporting on mortality and suggested additional analyses for exploring why the differences could be occurring. These analyses indicated that, by chance, older and sicker patients were being randomized to the drugs with the higher mortality rates. By the end of the study, the observed differences in mortality between drug groups had evened out. The DSMB's thoughtful recommendations, support and monitoring ensured that the study was successfully completed without endangering the study patients. JF - Controlled clinical trials AU - Collins, Joseph F AD - Cooperative Studies Program Coordinating Center, VA Medical Center, Perry Point, MD 21902, USA. joseph.collins2@med.va.gov Y1 - 2003/02// PY - 2003 DA - February 2003 SP - 71 EP - 77 VL - 24 IS - 1 SN - 0197-2456, 0197-2456 KW - Anticonvulsants KW - 0 KW - Index Medicus KW - United States KW - Therapeutic Human Experimentation -- ethics KW - Humans KW - Safety KW - Data Interpretation, Statistical KW - Patient Selection KW - Clinical Trials Data Monitoring Committees KW - Anticonvulsants -- adverse effects KW - Randomized Controlled Trials as Topic -- standards KW - Anticonvulsants -- administration & dosage KW - Epilepsy -- drug therapy KW - Research Design KW - Randomized Controlled Trials as Topic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72988087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Controlled+clinical+trials&rft.atitle=Data+and+safety+monitoring+board+issues+raised+in+the+VA+Status+Epilepticus+Study.&rft.au=Collins%2C+Joseph+F&rft.aulast=Collins&rft.aufirst=Joseph&rft.date=2003-02-01&rft.volume=24&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Controlled+clinical+trials&rft.issn=01972456&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-29 N1 - Date created - 2003-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Screening for substance abuse and psychiatric disorders among women patients in a VA Health Care System. AN - 72983417; 12556603 AB - This study of women Veterans Affairs (VA) health care patients screened for the prevalence of past-year smoking, hazardous and problem drinking, other drug abuse, and psychiatric disorders. A survey was mailed to women veterans who had received care from VA Puget Sound Health Care System between October 1, 1996, and January 1, 1998. Screening measures included questions about cigarettes; questions from the Alcohol Use Disorders Identification Test about consumption (hazardous drinking); the TWEAK test (problem drinking); a drug abuse screen; the Patient Health Questionnaire (psychiatric conditions); and the PTSD (posttraumatic stress disorder) Checklist. Of eligible patients, 1,257 (65 percent) returned surveys with complete substance use data. Patients reported a relatively high rate of past-year smoking (29.1 percent) and hazardous drinking, problem drinking, or both (31.1 percent). The rate of past-year drug use was much lower (4.9 percent). Younger age was strongly associated with greater substance abuse: 59 percent of women under age 35 screened positive for smoking, hazardous or problem drinking, or drug abuse. Screening positive for a psychiatric condition (N=504) was also associated with substance abuse: The rate of past-year drug abuse among women screening positive for a psychiatric condition (9.7 percent) was double the rate for the entire sample. Of the women who screened positive for depression, PTSD, eating disorders, or panic disorders, 57 percent screened positive for substance abuse (including smoking). Substance abuse is common among women VA patients and is associated with younger age and with screening positive for other psychiatric conditions. Providers are expected to follow up on positive screening tests, and these data indicate substantial provider burden. JF - Psychiatric services (Washington, D.C.) AU - Davis, Tania M AU - Bush, Kristen R AU - Kivlahan, Daniel R AU - Dobie, Dorcas J AU - Bradley, Katharine A AD - Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA. tania.davis@med.va.gov Y1 - 2003/02// PY - 2003 DA - February 2003 SP - 214 EP - 218 VL - 54 IS - 2 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - United States KW - Washington -- epidemiology KW - Women's Health KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Diagnosis, Dual (Psychiatry) KW - Middle Aged KW - Hospitals, Veterans -- utilization KW - Female KW - Prevalence KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Smoking -- therapy KW - Mass Screening KW - Mental Disorders -- diagnosis KW - Mental Disorders -- therapy KW - Veterans -- statistics & numerical data KW - Mental Disorders -- epidemiology KW - Veterans -- psychology KW - Mental Health Services -- utilization KW - Smoking -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72983417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Screening+for+substance+abuse+and+psychiatric+disorders+among+women+patients+in+a+VA+Health+Care+System.&rft.au=Davis%2C+Tania+M%3BBush%2C+Kristen+R%3BKivlahan%2C+Daniel+R%3BDobie%2C+Dorcas+J%3BBradley%2C+Katharine+A&rft.aulast=Davis&rft.aufirst=Tania&rft.date=2003-02-01&rft.volume=54&rft.issue=2&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-15 N1 - Date created - 2003-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anti-neurofilament antibodies in neuropathy with monoclonal gammopathy of undetermined significance produce experimental motor nerve conduction block. AN - 72961192; 12536221 AB - Elevated levels of serum antibodies to neurofilament proteins have been associated with a variety of neurological diseases, including autoimmune disorders such as neuropathy with monoclonal gammopathy of undetermined significance (MGUS). The pathological significance of anti-neurofilament antibodies in sera of affected patients, however, remains unclear. In this study, we report our findings of polyclonal antibodies in sera from 4 of 16 IgG MGUS neuropathy patients that react strongly on immunoblot with a high molecular weight neurofilament protein (NFH). The effect of anti-NFH polyclonal antibody on peripheral nerve function was tested in vivo by intraneural injection. Sera containing anti-NFH antibody, but not sera from age-matched control subjects, injected into the endoneurium of rat sciatic nerve significantly attenuated proximal-evoked motor nerve compound muscle action potential (CMAP) amplitudes in a complement-dependent manner. In contrast, ankle-evoked CMAP amplitudes were unaffected by intraneural injection of sera containing anti-NFH antibody. Anti-NFH serum-injected nerves showed changes in both axon caliber (shrinkage) and myelin ultrastructure (vesiculation and ovoid formation), suggestive of intramyelinic edema. Preincubation of sera containing anti-NFH antibody with purified NFH protein abolished immunoreactivity to NFH protein and neutralized the serum-mediated toxicity. The data suggest that anti-NFH polyclonal antibodies occurring in sera of some patients with IgG MGUS neuropathy may elicit peripheral nerve conduction block independent of the patients' IgG paraprotein. Anti-neural polyclonal antibodies in sera of IgG MGUS neuropathy patients may have a greater pathological significance than previously anticipated. JF - Acta neuropathologica AU - Stubbs, Evan B AU - Lawlor, Mike W AU - Richards, Michael P AU - Siddiqui, Kiran AU - Fisher, Morris A AU - Bhoopalam, Nirmala AU - Siegel, George J AD - Neurology Service, Edward Hines, Jr. VA Hospital, IL 60141, USA. evan.stubbs@med.va.gov Y1 - 2003/02// PY - 2003 DA - February 2003 SP - 109 EP - 116 VL - 105 IS - 2 SN - 0001-6322, 0001-6322 KW - Immunoglobulin G KW - 0 KW - Neurofilament Proteins KW - Index Medicus KW - Rats KW - Immunoglobulin G -- blood KW - Animals KW - Action Potentials -- physiology KW - Neural Conduction -- drug effects KW - Humans KW - Immunoglobulin G -- pharmacology KW - Electromyography KW - Aged KW - Neurons -- ultrastructure KW - Male KW - Neurons -- pathology KW - Sciatic Nerve -- ultrastructure KW - Neurofilament Proteins -- immunology KW - Monoclonal Gammopathy of Undetermined Significance -- immunology KW - Sciatic Nerve -- pathology KW - Sciatic Nerve -- physiopathology KW - Sciatic Nerve -- drug effects KW - Peripheral Nervous System Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72961192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+neuropathologica&rft.atitle=Anti-neurofilament+antibodies+in+neuropathy+with+monoclonal+gammopathy+of+undetermined+significance+produce+experimental+motor+nerve+conduction+block.&rft.au=Stubbs%2C+Evan+B%3BLawlor%2C+Mike+W%3BRichards%2C+Michael+P%3BSiddiqui%2C+Kiran%3BFisher%2C+Morris+A%3BBhoopalam%2C+Nirmala%3BSiegel%2C+George+J&rft.aulast=Stubbs&rft.aufirst=Evan&rft.date=2003-02-01&rft.volume=105&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Acta+neuropathologica&rft.issn=00016322&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-23 N1 - Date created - 2003-01-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Detecting adverse events for patient safety research: a review of current methodologies AN - 18956305; 5739182 AB - Promoting patient safety is a national priority. To evaluate interventions for reducing medical errors and adverse event, effective methods for detecting such events are required. This paper reviews the current methodologies for detection of adverse events and discusses their relative advantages and limitations. It also presents a cognitive framework for error monitoring and detection. While manual chart review has been considered the 'gold-standard' for identifying adverse events in many patient safety studies, this methodology is expensive and imperfect. Investigators have developed or are currently evaluating, several electronic methods that can detect adverse events using coded data, free-text clinical narratives, or a combination of techniques. Advances in these systems will greatly facilitate our ability to monitor adverse events and promote patient safety research. But these systems will perform optimally only if we improve our understanding of the fundamental nature of errors and the ways in which the human mind can naturally, but erroneously, contribute to the problems that we observe. JF - Journal of Biomedical Informatics AU - Murff, HJ AU - Patel, V L AU - Hripcsak, G AU - Bates, D W AD - Department of Veterans Affairs, Tennessee Valley Healthcare System, GRECC, 1310 24th Avenue South, Nashville, TN 37212-2637, USA, harvey.murff@med.va.gov Y1 - 2003/02// PY - 2003 DA - Feb 2003 SP - 131 EP - 143 PB - Academic Press, Inc., 525 B St. Ste. 1900 San Diego CA 92101-4495 USA, [mailto:apsubs@acad.com] VL - 36 IS - 1-2 SN - 1532-0464, 1532-0464 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Reviews KW - Safety KW - Patients KW - Bioinformatics KW - Errors KW - W4 140:Bioinformatics & Computers in Health & Medicine KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18956305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=Detecting+adverse+events+for+patient+safety+research%3A+a+review+of+current+methodologies&rft.au=Murff%2C+HJ%3BPatel%2C+V+L%3BHripcsak%2C+G%3BBates%2C+D+W&rft.aulast=Murff&rft.aufirst=HJ&rft.date=2003-02-01&rft.volume=36&rft.issue=1-2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2003.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bioinformatics; Patients; Safety; Reviews; Errors DO - http://dx.doi.org/10.1016/j.jbi.2003.08.003 ER - TY - JOUR T1 - Occurrence of Extended-Spectrum and AmpC Beta-Lactamases in Bloodstream Isolates of Klebsiella pneumoniae: Isolates Harbor Plasmid-Mediated FOX-5 and ACT-1 AmpC Beta-Lactamases AN - 18658307; 5563638 AB - We tested 190 Klebsiella pneumoniae bloodstream isolates recovered from 189 patients in 30 U.S. hospitals in 23 states to determine the occurrence of extended-spectrum beta -lactamase (ESBL) and AmpC beta -lactamase producers. Based on growth inhibition by clavulanic acid by disk and MIC test methods, 18 (9.5%) of the isolates produced ESBLs. Although the disk diffusion method with standard breakpoints identified 28 cefoxitin-nonsusceptible isolates, only 5 (18%) of these were confirmed as AmpC producers. Of two AmpC confirmatory tests, the three-dimensional extract test was easier to perform than was the double-disk approximation test using a novel inhibitor, Syn2190. Three of the five AmpC producers carried the bla sub(FOX-5) gene, while the other two isolates harbored the bla sub(ACT-1) gene. All AmpC genes were transferable. In vitro susceptibility testing with standard inocula showed that all five AmpC-producing strains were susceptible to cefepime, imipenem, and ertapenem but that with a high inoculum, more of these strains were susceptible to the carbapenems than to cefepime. All but 1 of 14 screen-positive AmpC nonproducers (and ESBL nonproducers) were susceptible to ceftriaxone and cefepime at the standard inoculum as were 6 of 6 isolates that were randomly selected and tested with a high inoculum. These results indicate that (i) a significant number of K. pneumoniae bloodstream isolates harbor ESBL or AmpC beta -lactamases, (ii) confirmatory tests are necessary to identify true AmpC producers, and (iii) in vitro, carbapenems are active against AmpC-producing strains of K. pneumoniae. JF - Journal of Clinical Microbiology AU - Coudron, P E AU - Hanson, N D AU - Climo, M W AD - Pathology & Laboratory Medicine Service/113, McGuire Veterans Affairs Medical Center, 1201 Broad Rock Blvd., Richmond, VA 23249-0001, Philip.Coudron@med.va.gov Y1 - 2003/02// PY - 2003 DA - Feb 2003 SP - 772 EP - 777 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 41 IS - 2 SN - 0095-1137, 0095-1137 KW - AmpC protein KW - man KW - Microbiology Abstracts B: Bacteriology KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18658307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Occurrence+of+Extended-Spectrum+and+AmpC+Beta-Lactamases+in+Bloodstream+Isolates+of+Klebsiella+pneumoniae%3A+Isolates+Harbor+Plasmid-Mediated+FOX-5+and+ACT-1+AmpC+Beta-Lactamases&rft.au=Coudron%2C+P+E%3BHanson%2C+N+D%3BClimo%2C+M+W&rft.aulast=Coudron&rft.aufirst=P&rft.date=2003-02-01&rft.volume=41&rft.issue=2&rft.spage=772&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.41.2.772-777.2003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1128/JCM.41.2.772-777.2003 ER - TY - JOUR T1 - Sequences required for the transition from monomeric to homodimeric forms of thyroid hormone receptor alpha and v-erbA. AN - 73020569; 12581880 AB - Thyroid hormone receptor alpha (TRalpha) and the oncoprotein v-erbA (a mutated form of TRalpha incapable of binding T3) bind as heterodimers with retinoid X receptor (RXR) to DNA sequences with different orientations of AGGTCA half sites. v-erbA can also form homodimers, whereas, TRalpha1 homodimerizes poorly. Therefore, in order to obtain a better understanding for the distinct homodimerization properties between TRalpha1 and v-erbA, we created chimeras between these two receptors and tested their abilities to homodimerize on direct and everted repeats (DRs, ERs). We found that the enhanced homodimerization properties of v-erbA compared to TRalpha1 map to isoleucine at position 339 in conjunction with serine at position 351 and alanine at position 358. Our data indicate that the methyl group in isoleucine at position 339 plays an important role in v-erbA homodimerization, particularly on ER 6. Functional studies with I339V+S351P+A358T, a v-erbA mutant unable to homodimerize but still able to heterodimerize with RXR on ERs and DRs, indicate that v-erbA-RXR heterodimers mediate the dominant negative activity of v-erbA on DRs. However, the repressor activity of this mutant is weaker than that of the wild type v-erbA on ERs, suggesting that v-erbA homodimers rather than v-erbA-RXR heterodimers mediate the potent dominant negative activity of v-erbA on ERs. JF - Molecular and cellular endocrinology AU - Zubkova, Inna AU - Subauste, Jose S AD - G.V. Montgomery Veterans Administration Medical Center, R&E Building (151), 1500 E. Woodrow Wilson Blvd., Jackson, MS 39216, USA. Y1 - 2003/01/31/ PY - 2003 DA - 2003 Jan 31 SP - 61 EP - 72 VL - 199 IS - 1-2 SN - 0303-7207, 0303-7207 KW - Oncogene Proteins v-erbA KW - 0 KW - Receptors, Retinoic Acid KW - Recombinant Fusion Proteins KW - Retinoid X Receptors KW - Thyroid Hormone Receptors alpha KW - Transcription Factors KW - Index Medicus KW - Receptors, Retinoic Acid -- metabolism KW - Animals KW - Protein Structure, Secondary KW - Transcription Factors -- metabolism KW - Dimerization KW - Mice KW - Amino Acid Sequence -- physiology KW - Mutagenesis, Site-Directed KW - Sequence Alignment KW - Transfection KW - Molecular Sequence Data KW - Point Mutation KW - Recombinant Fusion Proteins -- genetics KW - Thyroid Hormone Receptors alpha -- genetics KW - Oncogene Proteins v-erbA -- chemistry KW - Thyroid Hormone Receptors alpha -- metabolism KW - Oncogene Proteins v-erbA -- genetics KW - Oncogene Proteins v-erbA -- metabolism KW - Thyroid Hormone Receptors alpha -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73020569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+endocrinology&rft.atitle=Sequences+required+for+the+transition+from+monomeric+to+homodimeric+forms+of+thyroid+hormone+receptor+alpha+and+v-erbA.&rft.au=Zubkova%2C+Inna%3BSubauste%2C+Jose+S&rft.aulast=Zubkova&rft.aufirst=Inna&rft.date=2003-01-31&rft.volume=199&rft.issue=1-2&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+endocrinology&rft.issn=03037207&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-05 N1 - Date created - 2003-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Post-Traumatic Stress Disorder and Chronic Fatigue Syndrome-like Illness among Gulf War Veterans: A Population-based Survey of 30,000 Veterans AN - 18756596; 5637725 AB - The authors estimated the prevalence of post-traumatic stress disorder (PTSD) and illness resembling chronic fatigue syndrome (CFS) in the entire population of Gulf War and non-Gulf-War veterans. They also evaluated the relation between the extent of deployment-related stress and the risk of either PTSD or CFS. In 1995-1997, the authors conducted a health survey in which these two symptom-based medical diagnoses in a population-based sample of 15,000 Gulf War veterans representing four military branches and three unit components (active, reserve, and National Guard) were compared with those of 15,000 non-Gulf veteran controls. Gulf War veterans, compared with non-Gulf veteran controls, reported significantly higher rates of PTSD (adjusted odds ratio = 3.1, 95% confidence interval: 2.7, 3.4) and CFS (adjusted odds ratio = 4.8, 95% confidence interval: 3.9, 5.9). The prevalence of PTSD increased monotonically across six levels of deployment-related stress intensity (test for trend: p < 0.01), while the prevalence of CFS rose only at the low end of the stress spectrum. While deployment-related stress could account for the higher risks of both PTSD and CFS, additional factor(s) unique to the Gulf environment may have contributed to the risk of CFS among Gulf War veterans. JF - American Journal of Epidemiology AU - Kang, H K AU - Natelson, B H AU - Mahan, C M AU - Lee, KY AU - Murphy, F M AD - Veterans Health Administration, Department of Veterans Affairs, Washington, DC, USA Y1 - 2003/01/15/ PY - 2003 DA - 2003 Jan 15 SP - 141 EP - 148 VL - 157 IS - 2 SN - 0002-9262, 0002-9262 KW - Gulf War Syndrome KW - chronic fatigue KW - posttraumatic stress disorder KW - Health & Safety Science Abstracts KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18756596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Post-Traumatic+Stress+Disorder+and+Chronic+Fatigue+Syndrome-like+Illness+among+Gulf+War+Veterans%3A+A+Population-based+Survey+of+30%2C000+Veterans&rft.au=Kang%2C+H+K%3BNatelson%2C+B+H%3BMahan%2C+C+M%3BLee%2C+KY%3BMurphy%2C+F+M&rft.aulast=Kang&rft.aufirst=H&rft.date=2003-01-15&rft.volume=157&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Symptom control. AN - 75755725; 14533447 AB - Symptom control has become increasingly recognized as an important goal in patient care. In this article, advances in symptom assessment, and various definitions of symptom improvement are reviewed. Theoretical concepts underlying symptom control and clinically significant change are presented, as well as the role of symptom control as an endpoint in clinical trials. Symptom control is then surveyed in two broad categories for selected symptoms. The first area is therapy related symptoms, secondary to chemotherapy, radiation, hormonal therapy, and surgery. Symptoms reviewed include chemotherapy related mucositis, emesis, fatigue; hot flashes; and radiation related dermatitis, xerostomia, and mucositis. The second area is palliative oncologic approaches to disease-related symptoms. Results in palliative chemotherapy, palliative radiation therapy, cancer pain, and lack of appetite are summarized. Areas requiring further research are noted. Findings are presented in both a clinical and research context to help guide the reader with interpreting symptom control studies. JF - Cancer investigation AU - Chang, Victor T AU - Ingham, Jane AD - UMDNJ/New Jersey Medical School, VA New Jersey Health Care System, 385 Tremont Avenue, East Orange, NJ 07018, USA. victor.chang@med.va.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 564 EP - 578 VL - 21 IS - 4 SN - 0735-7907, 0735-7907 KW - Antineoplastic Agents KW - 0 KW - Antineoplastic Agents, Hormonal KW - Index Medicus KW - Endpoint Determination KW - Humans KW - Antineoplastic Agents, Hormonal -- adverse effects KW - Radiotherapy -- adverse effects KW - Antineoplastic Agents -- adverse effects KW - Neoplasms -- complications KW - Quality of Life KW - Palliative Care KW - Neoplasms -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/75755725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+investigation&rft.atitle=Symptom+control.&rft.au=Chang%2C+Victor+T%3BIngham%2C+Jane&rft.aulast=Chang&rft.aufirst=Victor&rft.date=2003-01-01&rft.volume=21&rft.issue=4&rft.spage=564&rft.isbn=&rft.btitle=&rft.title=Cancer+investigation&rft.issn=07357907&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-10-23 N1 - Date created - 2003-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antidepressant-related erectile dysfunction: management via avoidance, switching antidepressants, antidotes, and adaptation. AN - 73663116; 12971811 AB - The ideal antidepressant would control depression with no adverse effect on sexual function. Erectile dysfunction and other sexual dysfunction associated with antidepressant medication treatment are problems with many antidepressants and can lead to patient dissatisfaction and decreased compliance with treatment. A computerized MEDLINE search (English language, 1966-2003) was performed using the terms antidepressive agents, erectile dysfunction, and sexual dysfunction. Emphasis was placed on studies with specific sexual function measurements taken before and after treatment and placebo control. Mixed mediator, nonserotonergic antidepressants that block postsynaptic serotonin type 2 receptors (nefazodone, mirtazapine) or that primarily increase dopamine or norepinephrine levels (bupropion) were thought to be good choices for avoiding antidepressant-associated sexual dysfunction or for switching patients in whom antidepressant-associated sexual dysfunction emerged. Comparisons with serotonin reuptake inhibitors (SRIs) have revealed less desire and orgasm dysfunction with nonserotonergic bupropion, less orgasm dysfunction with nefazodone, and superior overall satisfaction with sexual functioning with bupropion or nefazodone. However, most of these studies have design flaws that make evidence-based claims of efficacy difficult to substantiate. Agents proposed for antidote use in antidepressant-associated sexual dysfunction have either not been studied in men or not proved efficacious in randomized placebo-controlled trials. Switching to and augmentation with bupropion or nefazodone have also not clearly shown efficacy in controlled trials and require care and monitoring to avoid SRI discontinuation symptoms and loss of antidepressant efficacy. Few proposed treatment options, apart from avoidance, have proved effective for antidepressant-associated sexual dysfunction, which can have negative consequences on depression management. JF - The Journal of clinical psychiatry AU - Labbate, Lawrence A AU - Croft, Harry A AU - Oleshansky, Marvin A AD - Department of Psychiatry and Behavioral Science, Medical University of South Carolina and Veterans Administration Medical Center, Charleston, SC, USA. labbatel@musc.edu Y1 - 2003 PY - 2003 DA - 2003 SP - 11 EP - 19 VL - 64 Suppl 10 SN - 0160-6689, 0160-6689 KW - Antidepressive Agents KW - 0 KW - Serotonin Uptake Inhibitors KW - Triazoles KW - Bupropion KW - 01ZG3TPX31 KW - Doxepin KW - 1668-19-5 KW - Mianserin KW - 250PJI13LM KW - nefazodone KW - 59H4FCV1TF KW - mirtazapine KW - A051Q2099Q KW - Moclobemide KW - PJ0Y7AZB63 KW - Index Medicus KW - Orgasm -- drug effects KW - Moclobemide -- therapeutic use KW - Moclobemide -- adverse effects KW - Bupropion -- therapeutic use KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Humans KW - Bupropion -- adverse effects KW - Triazoles -- adverse effects KW - Remission, Spontaneous KW - Serotonin Uptake Inhibitors -- adverse effects KW - Controlled Clinical Trials as Topic KW - Drug Tolerance KW - Doxepin -- adverse effects KW - Treatment Outcome KW - Triazoles -- therapeutic use KW - Doxepin -- therapeutic use KW - Male KW - Erectile Dysfunction -- chemically induced KW - Mianserin -- therapeutic use KW - Mianserin -- adverse effects KW - Depressive Disorder -- drug therapy KW - Antidepressive Agents -- therapeutic use KW - Antidepressive Agents -- adverse effects KW - Erectile Dysfunction -- therapy KW - Mianserin -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73663116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Antidepressant-related+erectile+dysfunction%3A+management+via+avoidance%2C+switching+antidepressants%2C+antidotes%2C+and+adaptation.&rft.au=Labbate%2C+Lawrence+A%3BCroft%2C+Harry+A%3BOleshansky%2C+Marvin+A&rft.aulast=Labbate&rft.aufirst=Lawrence&rft.date=2003-01-01&rft.volume=64+Suppl+10&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-08 N1 - Date created - 2003-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk-attitude and patient treatment preferences. AN - 73341897; 12765300 AB - Women's treatment preferences for lupus nephritis vary widely even after adjusting for sociodemographic factors and disease severity. Attitude toward risk may partially explain interpatient variability in treatment preference. The objective of this study was to examine the association between 'risk-attitude' and patient treatment preferences in lupus nephritis. Sixty-five premenopausal women with systemic lupus erythematosus were interviewed. Patient preferences for cyclophosphamide versus azathioprine for the treatment of lupus nephritis were ascertained using an Adaptive Conjoint Analysis questionnaire. Risk-attitude was ascertained by asking patients to choose between a pair of lotteries having the same expected value but differing in spread (the difference between the worst and best outcomes). Respondents preferring the wider spread were classified as relatively more risk-seeking and those preferring the narrower spread were classified as relatively more risk-averse. Twenty-eight percent of respondents were classified as relatively more risk-seeking. Risk-seeking women were more likely to prefer cyclophosphamide for the treatment of lupus nephritis compared with risk-averse women [least square mean (+/- SD) preference for cyclophosphamide 63 +/- 3 among risk-seeking women versus 55 +/- 2 among risk-averse women (P < 0.03)]. The association between risk attitude and treatment preference persisted asthe probabilities of adverse events were varied to reflect the range of risks reported in the literature. Our results suggest that patients' relative risk-attitudes, as measured by a lottery task, are related to their treatment preferences. Differences in risk-attitude may help explain the inter-patient variability in treatment preferences. JF - Lupus AU - Fraenkel, L AU - Bogardus, S T AU - Wittink, D R AD - VA Connecticut Health Care System, West Haven, CT 06516, USA. liana.fraenkel@med.va.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 370 EP - 376 VL - 12 IS - 5 SN - 0961-2033, 0961-2033 KW - Antirheumatic Agents KW - 0 KW - Cyclophosphamide KW - 8N3DW7272P KW - Azathioprine KW - MRK240IY2L KW - Index Medicus KW - Cyclophosphamide -- therapeutic use KW - Azathioprine -- adverse effects KW - Humans KW - Azathioprine -- therapeutic use KW - Antirheumatic Agents -- adverse effects KW - Adult KW - Treatment Outcome KW - Decision Making KW - Female KW - Antirheumatic Agents -- therapeutic use KW - Risk Assessment KW - Cyclophosphamide -- adverse effects KW - Lupus Nephritis -- drug therapy KW - Attitude to Health KW - Patient Participation KW - Lupus Nephritis -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73341897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lupus&rft.atitle=Risk-attitude+and+patient+treatment+preferences.&rft.au=Fraenkel%2C+L%3BBogardus%2C+S+T%3BWittink%2C+D+R&rft.aulast=Fraenkel&rft.aufirst=L&rft.date=2003-01-01&rft.volume=12&rft.issue=5&rft.spage=370&rft.isbn=&rft.btitle=&rft.title=Lupus&rft.issn=09612033&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-16 N1 - Date created - 2003-05-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ligand-induced mu opioid receptor endocytosis and recycling in enteric neurons. AN - 73318912; 12763066 AB - Immunohistochemistry and confocal microscopy were used to investigate endocytosis and recycling of the native mu opioid receptor (muOR) in enteric neurons. Isolated segments of the guinea-pig ileum were exposed to increasing concentrations of muOR agonists at 4 degrees C to allow ligand binding and warming to 37 degrees C for 0 min (baseline) to 6 h in ligand-free medium to allow receptor internalization and recycling. The endogenous ligand, [Met]enkephalin, and [D-Ala(2),MePhe(4),Gly-ol(5)] enkephalin (DAMGO), an opioid analog, and the alkaloids, etorphine and fentanyl, induced rapid internalization of muOR immunoreactivity in enteric neurons, whereas morphine did not. muOR internalization was prevented by muOR antagonists. Basal levels of muOR immunoreactivity in the cytoplasm were 10.52+/-2.05%. DAMGO (1 nM-100 microM) induced a concentration-dependent increase of muOR immunofluorescence density in the cytoplasm to a maximum of 84.37+/-2.26%. Translocation of muOR immunoreactivity in the cytoplasm was detected at 2 min, reached the maximum at 15-30 min, remained at similar levels for 2 h, began decreasing at 4 h, and was at baseline values at 6 h. A second exposure to DAMGO (100 nM) following recovery of internalized muOR immunoreactivity at the cell surface induced a translocation of muOR immunoreactivity in the cytoplasm comparable to the one observed following the first exposure (46.89+/-3.11% versus 43.31+/-3.80%). muOR internalization was prevented by hyperosmolar sucrose, phenylarsine oxide or potassium depletion, which inhibit clathrin-mediated endocytosis. muOR recycling was prevented by pre-treatment with bafilomycin A1, an acidotropic agent that inhibits endosomal acidification, but not by the protein synthesis inhibitor, cycloheximide. This study shows that native muOR in enteric neurons undergoes ligand-selective endocytosis, which is primarily clathrin-mediated, and recycles following endosomal acidification. Following recycling, muOR is activated and internalized by DAMGO indicating that recycled receptors are functional. JF - Neuroscience AU - Minnis, J G AU - Patierno, S AU - Kohlmeier, S E AU - Brecha, N C AU - Tonini, M AU - Sternini, C AD - CURE Digestive Diseases Research Center, Building 115, Veterans Administration Greater Los Angeles Healthcare System, Digestive Diseases Division, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA. Y1 - 2003 PY - 2003 DA - 2003 SP - 33 EP - 42 VL - 119 IS - 1 SN - 0306-4522, 0306-4522 KW - Analgesics, Opioid KW - 0 KW - Arsenicals KW - Enkephalins KW - Enzyme Inhibitors KW - Ligands KW - Narcotic Antagonists KW - Receptors, Opioid, mu KW - oxophenylarsine KW - 0HUR2WY345 KW - Enkephalin, Ala(2)-MePhe(4)-Gly(5)- KW - 100929-53-1 KW - phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide KW - 103429-31-8 KW - Naloxone KW - 36B82AMQ7N KW - Somatostatin KW - 51110-01-1 KW - Sucrose KW - 57-50-1 KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Animals KW - Naloxone -- pharmacology KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Guinea Pigs KW - Arsenicals -- pharmacology KW - Enkephalins -- pharmacology KW - Microscopy, Confocal -- instrumentation KW - Potassium -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Sucrose -- pharmacology KW - Microscopy, Confocal -- methods KW - Time Factors KW - Organ Culture Techniques KW - Narcotic Antagonists -- pharmacology KW - Immunohistochemistry KW - Somatostatin -- pharmacology KW - Neurons -- metabolism KW - Enkephalin, Ala(2)-MePhe(4)-Gly(5)- -- pharmacology KW - Analgesics, Opioid -- pharmacology KW - Neurons -- drug effects KW - Ileum -- drug effects KW - Endocytosis -- drug effects KW - Ileum -- metabolism KW - Receptors, Opioid, mu -- drug effects KW - Somatostatin -- analogs & derivatives KW - Receptors, Opioid, mu -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73318912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Ligand-induced+mu+opioid+receptor+endocytosis+and+recycling+in+enteric+neurons.&rft.au=Minnis%2C+J+G%3BPatierno%2C+S%3BKohlmeier%2C+S+E%3BBrecha%2C+N+C%3BTonini%2C+M%3BSternini%2C+C&rft.aulast=Minnis&rft.aufirst=J&rft.date=2003-01-01&rft.volume=119&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-07-28 N1 - Date created - 2003-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Questions and answers for the advanced practice psychiatric nurse. AN - 73243129; 12724964 AB - Because of the importance of maintaining current knowledge of technological advances involving genetics, neuroscience, and their impact on psychopharmacology, we have created a new column for advanced practice psychiatric nurses. This new column offers a question-and-answer forum that can help nurses maintain their knowledge of advances in prescribing and psychopharmacology, and implications for safe psychiatric care. Deborah Antai-Otong has a wealth of knowledge and expertise with prescriptive authority and as a psychotherapist. She currently manages the care of patients with various psychiatric disorders including mood disorders, schizophrenia, dual diagnosis, and anxiety disorders. She is the author of numerous refereed journal articles and book chapters that focus on psychopharmacology and is a guest lecturer at a local university on this topic. She is also the author of several books, including Psychiatric Nursing: Biological and Behavioral Concepts (Clifton Park, NY: Delmar & Thompson Learning, 2003) and Psychiatric Emergencies (Eau Claire, WI: PESI, 2001). JF - Perspectives in psychiatric care AU - Antai-Otong, Deborah AD - VA North Texas Health Care System, Dallas, TX, USA. Deborah.Antai-otong@med.va.gov PY - 2003 SP - 33 EP - 34 VL - 39 IS - 1 SN - 0031-5990, 0031-5990 KW - Cytochrome P-450 Enzyme Inhibitors KW - 0 KW - Psychotropic Drugs KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Nursing KW - Drug Therapy, Combination KW - Drug Interactions KW - Nursing Assessment KW - Humans KW - Cytochrome P-450 Enzyme System -- biosynthesis KW - Mental Disorders -- diagnosis KW - Mental Disorders -- drug therapy KW - Mental Disorders -- nursing KW - Psychotropic Drugs -- therapeutic use KW - Psychotropic Drugs -- pharmacokinetics KW - Psychiatric Nursing KW - Psychotropic Drugs -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73243129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+in+psychiatric+care&rft.atitle=Questions+and+answers+for+the+advanced+practice+psychiatric+nurse.&rft.au=Antai-Otong%2C+Deborah&rft.aulast=Antai-Otong&rft.aufirst=Deborah&rft.date=2003-01-01&rft.volume=39&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Perspectives+in+psychiatric+care&rft.issn=00315990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-05 N1 - Date created - 2003-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aftermath of a patient's suicide: a case study. AN - 73239565; 12724962 AB - Nurse psychotherapists often feel poorly prepared to cope with a patient's death by suicide. The psychotherapist may identify with the family, feel sad at the death, and be plagued by feelings of guilt and responsibility. A case study illustrates the meaning of the loss to the therapist and the influence on professional identity, self-confidence, and self-esteem. Case study and review of the literature from Medline, psychinfo, and CINAHL. Therapists experience their own grief as a lack of omnipotence over suicide, and the fear of their colleagues' responses. Understanding bereavement and factors influencing bereavement may help therapists facilitate and reduce negative consequences of their own grief. JF - Perspectives in psychiatric care AU - Valente, Sharon M AD - University of Southern California, USA. sharon.valente@med.va.gov PY - 2003 SP - 17 EP - 22 VL - 39 IS - 1 SN - 0031-5990, 0031-5990 KW - Nursing KW - Depressive Disorder -- nursing KW - Nursing Assessment KW - Depressive Disorder -- psychology KW - Humans KW - Adult KW - Referral and Consultation KW - Nurse's Role KW - Alcoholism -- nursing KW - Alcoholism -- psychology KW - Female KW - Comorbidity KW - Risk Assessment KW - Psychotherapy KW - Psychiatric Nursing KW - Grief KW - Suicide -- psychology KW - Bereavement KW - Suicide -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73239565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+in+psychiatric+care&rft.atitle=Aftermath+of+a+patient%27s+suicide%3A+a+case+study.&rft.au=Valente%2C+Sharon+M&rft.aulast=Valente&rft.aufirst=Sharon&rft.date=2003-01-01&rft.volume=39&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Perspectives+in+psychiatric+care&rft.issn=00315990&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-05 N1 - Date created - 2003-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug interactions with cholinesterase inhibitors. AN - 73230867; 12710863 AB - Cholinesterase inhibitors are used for the symptomatic treatment of patients with Alzheimer's disease. This population often has numerous comorbidities and receives treatment with multiple medications. The astute clinician should remain mindful of possible drug interactions, both pharmacokinetic and pharmacodynamic, that may occur with concomitant treatment. Although pharmacokinetic interactions have been reported, pharmacodynamic interactions play a far greater role in the significance of drug interactions, with anticholinergic medications being most concerning. Commonly prescribed medications, such as antihistamines and tricyclic antidepressants, often have anticholinergic properties that alone or in combination with one another can antagonise the effects of cholinesterase inhibitors. Other medication classes such as antipsychotics and cholinergic agents may also result in pharmacodynamic interactions. However, for the most part, cholinesterase inhibitors can be used safely in combination with other medications. JF - Drugs & aging AU - Defilippi, Jennifer L AU - Crismon, M Lynn AD - Central Texas Veterans Health Care System, Mental Health Clinic, Temple, Texas 76504, USA. Jennifer.Faulkner1@med.va.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 437 EP - 444 VL - 20 IS - 6 SN - 1170-229X, 1170-229X KW - Cholinesterase Inhibitors KW - 0 KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Interactions KW - Humans KW - Clinical Trials as Topic KW - Aged KW - Cholinesterase Inhibitors -- pharmacology KW - Cholinesterase Inhibitors -- therapeutic use KW - Alzheimer Disease -- drug therapy KW - Cholinesterase Inhibitors -- pharmacokinetics KW - Alzheimer Disease -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73230867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drugs+%26+aging&rft.atitle=Drug+interactions+with+cholinesterase+inhibitors.&rft.au=Defilippi%2C+Jennifer+L%3BCrismon%2C+M+Lynn&rft.aulast=Defilippi&rft.aufirst=Jennifer&rft.date=2003-01-01&rft.volume=20&rft.issue=6&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Drugs+%26+aging&rft.issn=1170229X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-09-17 N1 - Date created - 2003-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Physicians and the pharmaceutical industry: a dysfunctional relationship. AN - 73216413; 12721524 AB - The pharmaceutical industry is one of the largest and most profitable industries in the world, and in the United States, the industry has a particularly privileged economic position. Yet the cost of drugs in the United States is higher than anywhere else, due largely to the fact that the industry is focusing increasingly on marketing rather than on the development of meaningful new medications: available evidence does not support claims of great expense for the development of new drugs. Because of its vast resources, the pharmaceutical industry has assumed an increasing influence in medicine, which, given the differences in values and priorities between medicine and the drug companies, is a cause for concern. The pharmaceutical industry has acted to maximize its profits in ways that frequently conflict with medicine's need for truth and full disclosure. Indeed, the industry has arguably worked to compromise physicians' judgments, as well as academic standards. As a result, despite government regulation there have been unnecessary adverse effects from drugs. The experience with butorphanol (Stadol) exemplifies problems in the current system and the harm that can result. Changes are suggested to make the pharmaceutical industry more responsive to the needs of patients and physicians. JF - Perspectives in biology and medicine AU - Fisher, Morris A AD - Loyola University Stritch School of Medicine, Maywood, IL, USA. morris.fisher@med.va.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 254 EP - 272 VL - 46 IS - 2 SN - 0031-5982, 0031-5982 KW - Analgesics, Opioid KW - 0 KW - Butorphanol KW - QV897JC36D KW - Bioethics KW - Index Medicus KW - Health Care and Public Health KW - United States KW - Analgesics, Opioid -- economics KW - Butorphanol -- economics KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Social Control, Formal KW - United States Food and Drug Administration -- legislation & jurisprudence KW - Butorphanol -- adverse effects KW - Analgesics, Opioid -- adverse effects KW - Substance-Related Disorders -- prevention & control KW - Drug Industry -- economics KW - Physicians -- ethics KW - Drug Industry -- ethics KW - Interprofessional Relations -- ethics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73216413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+in+biology+and+medicine&rft.atitle=Physicians+and+the+pharmaceutical+industry%3A+a+dysfunctional+relationship.&rft.au=Fisher%2C+Morris+A&rft.aulast=Fisher&rft.aufirst=Morris&rft.date=2003-01-01&rft.volume=46&rft.issue=2&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Perspectives+in+biology+and+medicine&rft.issn=00315982&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-09-12 N1 - Date created - 2003-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Outcomes at 1 and 5 years for older patients with alcohol use disorders. AN - 73133380; 12646329 AB - Older patients with alcohol use disorders who had gone through residential treatment were compared with matched groups of young and middle-aged patients (N = 432 in each age group) on their 1- and 5-year outcomes, use of continuing care services, and outcome predictors. Older patients had better outcomes than did young and middle-aged patients but had comparable levels of continuing substance abuse care and 12-step self-help group involvement. Similar factors predicted outcomes across the age groups. Longer duration of continuing substance abuse care and greater self-help group involvement were related to better outcomes, as were patients' attitudes and coping strategies at program discharge. The findings indicate that older patients with alcohol use disorders respond to age-integrated substance abuse treatment programs at least as well as do younger patients and are equally involved in formal and informal continuing substance abuse care. JF - Journal of substance abuse treatment AU - Lemke, Sonne AU - Moos, Rudolf H AD - Center for Health Care Evaluation and Program Evaluation and Resource Center (152 Palo Alto), Veterans Affairs Health Care System, 795 Willow Road, Menlo Park, CA 94025, USA. sonne.lemke@med.va.gov Y1 - 2003/01// PY - 2003 DA - January 2003 SP - 43 EP - 50 VL - 24 IS - 1 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Age Factors KW - Motivation KW - Humans KW - Prognosis KW - Self-Help Groups KW - Risk Factors KW - Adult KW - Patient Dropouts KW - Treatment Outcome KW - Sampling Studies KW - Follow-Up Studies KW - Middle Aged KW - Female KW - Male KW - Alcoholism -- rehabilitation KW - Alcoholism -- diagnosis KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73133380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Outcomes+at+1+and+5+years+for+older+patients+with+alcohol+use+disorders.&rft.au=Lemke%2C+Sonne%3BMoos%2C+Rudolf+H&rft.aulast=Lemke&rft.aufirst=Sonne&rft.date=2003-01-01&rft.volume=24&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-05 N1 - Date created - 2003-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cognitive disparity in schizophrenics with and without cocaine dependency. AN - 73125271; 12646333 AB - Although cognition has been investigated in individuals with schizophrenia and in non-schizophrenic cocaine abusers, few studies have focused on cocaine-abusing schizophrenics. Previous studies have shown contradictory results despite the fact that individuals with schizophrenia and cocaine dependence have worse long-term outcomes, and that each disorder separately is associated with neuropsychological impairment. The present study intended to clarify these inconsistencies with a comprehensive neuropsychological battery. Twenty-four cocaine-dependent schizophrenics and 23 non-drug abusing schizophrenics were recruited from the VA. Participants were administered tests focusing on motor skills, processing speed, attention, concentration, and executive functioning. While individuals with schizophrenia and cocaine dependence performed worse on the Grooved Peg Board and the Stroop A, the non-drug abusing schizophrenics performed worse on Trails Part A and B. However, a MANOVA failed to show group differences in overall neuropsychological performance. These findings are similar to the existing literature and suggest that cocaine may compromise motor functioning. Copyright 2003 Elsevier Science Inc. JF - Journal of substance abuse treatment AU - Smelson, David A AU - Davis, Craig W AU - Eisenstein, Norman AU - Engelhart, Charles AU - Williams, John AU - Losonczy, Miklos F AU - Ziedonis, Douglas AD - Department of Veterans Affairs, VISN 3 Mental Illness, Research, Education and Clinical Center, Bronx, NY 10451, USA. david.smelson@med.va.gov Y1 - 2003/01// PY - 2003 DA - January 2003 SP - 75 EP - 79 VL - 24 IS - 1 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Veterans KW - Psychiatric Status Rating Scales KW - Humans KW - Task Performance and Analysis KW - Middle Aged KW - Neuropsychological Tests KW - Cognition Disorders -- etiology KW - Cognition Disorders -- diagnosis KW - Schizophrenic Psychology KW - Schizophrenia -- complications KW - Cocaine-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73125271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Cognitive+disparity+in+schizophrenics+with+and+without+cocaine+dependency.&rft.au=Smelson%2C+David+A%3BDavis%2C+Craig+W%3BEisenstein%2C+Norman%3BEngelhart%2C+Charles%3BWilliams%2C+John%3BLosonczy%2C+Miklos+F%3BZiedonis%2C+Douglas&rft.aulast=Smelson&rft.aufirst=David&rft.date=2003-01-01&rft.volume=24&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-05 N1 - Date created - 2003-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-term use of Viozan (sibenadet HCl) in patients with chronic obstructive pulmonary disease: results of a 1-year study. AN - 72997952; 12564610 AB - Viozan (sibenadet HCl, AR-C68397AA) is a novel dual D2 dopamine receptor, beta2-adrenoceptor agonist that has been investigated for efficacy in alleviating the symptoms of chronic obstructive pulmonary disease (COPD). The slowly progressive nature of this disease means that patients will require ongoing therapeutic management for many years, or even decades. With such long-term treatment, the safety profile of new agents will be of paramount importance. As part of the large-scale assessment of sibenadet, a 12-month safety study has been conducted. Following completion of a 2-week baseline period, 435 adults with stable, symptomatic, smoking-related COPD were randomized to receive either 500 microg sibenadet or placebo delivered via pressurized metered dose inhaler (pMDI), three times daily for 52 weeks. Sibenadet therapy was generally well tolerated, with the only notable differences seen in the incidence of tremor and taste of treatment (16.9% vs. 4.1% and 14.5% vs. 4.1% in the sibenadet and placebo groups respectively). There were a total of 79 patients with serious adverse events (SAEs), 43 (14.8%) in the sibenadet pMDI group and 36 (24.8%) in the placebo group. No clinically significant abnormal laboratory values or overall differences between treatment groups were noted. Similarly, there were no clinically significant differences between the two treatment groups for cardiac variables, or in vital signs. The secondary variables showed no notable differences with respect to lung function, exacerbations or health-related quality of life. Due to the effective beta2-agonist properties, patients in the sibenadet group did, however, report reduced rescue medication usage at all timepoints. While the results of this study show that, overall, sibenadet therapy was well tolerated, the lack of sustained benefit reported in large-scale clinical efficacy studies means that sibenadet development will not be continued. JF - Respiratory medicine AU - Hiller, F C AU - Alderfer, V AU - Goldman, M AD - Division of Pulmonary and Critical Care Medicine, University of Arkansas for Medical Sciences and the Little Rock Veterans Administration Medical Center, AK 72205, USA. Y1 - 2003/01// PY - 2003 DA - January 2003 SP - S45 EP - S52 VL - 97 Suppl A SN - 0954-6111, 0954-6111 KW - Adrenergic beta-2 Receptor Agonists KW - 0 KW - Bronchodilator Agents KW - Receptors, Adrenergic, beta-2 KW - Receptors, Dopamine D2 KW - Thiazoles KW - sibenadet KW - N32934RHGW KW - Index Medicus KW - Double-Blind Method KW - Humans KW - Smoking -- adverse effects KW - Receptors, Adrenergic, beta-2 -- administration & dosage KW - Quality of Life KW - Aged KW - Smoking -- physiopathology KW - Aged, 80 and over KW - Adult KW - Treatment Outcome KW - Forced Expiratory Volume -- physiology KW - Long-Term Care KW - Middle Aged KW - Metered Dose Inhalers KW - Administration, Inhalation KW - Female KW - Male KW - Thiazoles -- administration & dosage KW - Receptors, Dopamine D2 -- administration & dosage KW - Bronchodilator Agents -- administration & dosage KW - Receptors, Dopamine D2 -- agonists KW - Pulmonary Disease, Chronic Obstructive -- physiopathology KW - Pulmonary Disease, Chronic Obstructive -- drug therapy KW - Thiazoles -- adverse effects KW - Bronchodilator Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72997952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Respiratory+medicine&rft.atitle=Long-term+use+of+Viozan+%28sibenadet+HCl%29+in+patients+with+chronic+obstructive+pulmonary+disease%3A+results+of+a+1-year+study.&rft.au=Hiller%2C+F+C%3BAlderfer%2C+V%3BGoldman%2C+M&rft.aulast=Hiller&rft.aufirst=F&rft.date=2003-01-01&rft.volume=97+Suppl+A&rft.issue=&rft.spage=S45&rft.isbn=&rft.btitle=&rft.title=Respiratory+medicine&rft.issn=09546111&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-18 N1 - Date created - 2003-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characteristics of HIV patients who attempt suicide. AN - 72992239; 12558540 AB - To examine the risk factors for suicidal behaviour in human immunodeficiency virus (HIV) positive patients. HIV substance dependent positive patients who had attempted suicide were compared with HIV substance dependent positive patients who had never attempted suicide for suicide risk factors. Among the 149 HIV positive patients examined almost half had attempted suicide. Significantly more HIV positive patients who had attempted suicide were female. Attempters were significantly younger than non-attempters. Significantly more of the attempters had a family history of suicidal behaviour. Attempters also reported significantly more childhood trauma, scored significantly higher for neuroticism, had experienced significantly more comorbidity with depression, and more of them had received antidepressant medication. These data suggest that both distal and proximal risk factors are involved in suicidal behaviour in HIV positive substance dependent patients. JF - Acta psychiatrica Scandinavica AU - Roy, A AD - Psychiatry Service 116A, Department of Veterans Affairs, New Jersey Healthcare System, East Orange 07018, USA. alec.roy@med.va.gov Y1 - 2003/01// PY - 2003 DA - January 2003 SP - 41 EP - 44 VL - 107 IS - 1 SN - 0001-690X, 0001-690X KW - Antidepressive Agents KW - 0 KW - Index Medicus KW - Severity of Illness Index KW - Depressive Disorder, Major -- drug therapy KW - Risk Factors KW - Humans KW - Substance-Related Disorders -- etiology KW - Adult KW - Antidepressive Agents -- therapeutic use KW - Middle Aged KW - Depressive Disorder, Major -- etiology KW - Male KW - Female KW - Substance-Related Disorders -- epidemiology KW - HIV Seropositivity -- psychology KW - Suicide, Attempted -- statistics & numerical data KW - Suicide, Attempted -- psychology KW - HIV Seropositivity -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72992239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+psychiatrica+Scandinavica&rft.atitle=Characteristics+of+HIV+patients+who+attempt+suicide.&rft.au=Roy%2C+A&rft.aulast=Roy&rft.aufirst=A&rft.date=2003-01-01&rft.volume=107&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Acta+psychiatrica+Scandinavica&rft.issn=0001690X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-01 N1 - Date created - 2003-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Glucocorticoid-induced osteoporosis in patients with sarcoidosis. AN - 72979519; 12544077 AB - Patients with sarcoidosis are at risk for osteoporosis caused by glucocorticoid therapy. However, because of potential hypercalciuria and hypercalcemia, the usual conservative treatment for low bone mass, calcium and vitamin D supplements, may not be well tolerated. Patients with sarcoidosis referred to a metabolic bone clinic were compared with other sarcoidosis patients studied prospectively and patients with chronic obstructive pulmonary disease (COPD) or asthma. The subjects underwent bone mineral density (BMD) testing, and the sarcoidosis patients underwent mobility testing and measurements of serum and urine chemistries, vitamin D levels, bone turnover markers, and sex hormone levels. The subjects were mostly male African Americans in the 6th decade of life. Many took chronic oral glucocorticoid therapy and often used home oxygen therapy. Low hip BMD was common among the referred group, comparable with patients with COPD. Surprisingly, hypercalciuria and hypercalcemia were uncommon, and serum testosterone levels were frequently low. The use of calcium supplements, multivitamins containing vitamin D, and glucocorticoids had no impact on serum or urine calcium levels. From univariate analysis, potential risk factors for low hip BMD were low weight, low body mass index (BMI), advanced age, and current use of glucocorticoids. However, in stepwise multiple regression analysis, only low BMI predicted about 40% of hip BMD. Despite calcium and vitamin D supplements, this group of patients with sarcoidosis had low BMD but relatively infrequent hypercalciuria and hypercalcemia. No prediction model of BMD was adequate. Therefore, we conclude that each patient needs to be assessed individually, including measurement of BMD, serum and urine calcium, and sex steroid status. JF - The American journal of the medical sciences AU - Adler, Robert A AU - Funkhouser, Holly L AU - Petkov, Valentina I AU - Berger, Meredith M AD - Endocrinology and Metabolism Section, McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USA. robert.adler@med.va.gov Y1 - 2003/01// PY - 2003 DA - January 2003 SP - 1 EP - 6 VL - 325 IS - 1 SN - 0002-9629, 0002-9629 KW - Glucocorticoids KW - 0 KW - Vitamin D KW - 1406-16-2 KW - Testosterone KW - 3XMK78S47O KW - Calcitriol KW - FXC9231JVH KW - Calcifediol KW - P6YZ13C99Q KW - Calcium KW - SY7Q814VUP KW - Abridged Index Medicus KW - Index Medicus KW - Femoral Neck Fractures KW - Regression Analysis KW - Calcium -- blood KW - Humans KW - Retrospective Studies KW - Aged KW - Calcium -- administration & dosage KW - Pulmonary Disease, Chronic Obstructive -- physiopathology KW - Vitamin D -- administration & dosage KW - Body Mass Index KW - Calcitriol -- blood KW - Calcium -- urine KW - Asthma -- physiopathology KW - Calcifediol -- blood KW - Spine KW - Prospective Studies KW - Testosterone -- blood KW - Adult KW - Absorptiometry, Photon KW - Bone Density KW - Middle Aged KW - Dietary Supplements KW - Male KW - Female KW - Sarcoidosis -- physiopathology KW - Glucocorticoids -- adverse effects KW - Sarcoidosis -- drug therapy KW - Osteoporosis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72979519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+the+medical+sciences&rft.atitle=Glucocorticoid-induced+osteoporosis+in+patients+with+sarcoidosis.&rft.au=Adler%2C+Robert+A%3BFunkhouser%2C+Holly+L%3BPetkov%2C+Valentina+I%3BBerger%2C+Meredith+M&rft.aulast=Adler&rft.aufirst=Robert&rft.date=2003-01-01&rft.volume=325&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+the+medical+sciences&rft.issn=00029629&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-02-10 N1 - Date created - 2003-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The safety of valproic acid use for patients with hepatitis C infection. AN - 72948134; 12505820 AB - Valproic acid is frequently not recommended for patients with hepatic dysfunction. The authors evaluated the association between hepatitis C and alanine aminotransferase (ALT) values during valproic acid treatment. ALT changes in 564 individuals beginning valproic acid treatment were examined. Changes among those with positive hepatitis C status were compared with changes among patients with positive hepatitis C status who were taking other psychotropic agents. ALT elevations with valproic acid were significantly greater among patients with positive hepatitis C status than those with negative or unknown status. Among patients with positive hepatitis C status, ALT increases did not differ significantly between valproic acid and other medications. Use of valproic acid may be possible for some patients with hepatitis C. ALT increases in seropositive patients may be partially related to chronic hepatitis infection. However, ALT levels should be closely monitored in all hepatitis C patients taking valproic acid. JF - The American journal of psychiatry AU - Felker, Bradford L AU - Sloan, Kevin L AU - Dominitz, Jason A AU - Barnes, Robert F AD - Department of Veteran Affairs Puget Sound Health Care System, MHC/116, 1660 South Columbian Way, Seattle, WA 98108-1597, USA. bradford.felker@med.va.gov Y1 - 2003/01// PY - 2003 DA - January 2003 SP - 174 EP - 178 VL - 160 IS - 1 SN - 0002-953X, 0002-953X KW - Valproic Acid KW - 614OI1Z5WI KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Abridged Index Medicus KW - Index Medicus KW - Risk KW - Humans KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Female KW - Chemical and Drug Induced Liver Injury -- etiology KW - Alanine Transaminase -- blood KW - Hepatitis C -- complications KW - Chemical and Drug Induced Liver Injury -- diagnosis KW - Mental Disorders -- drug therapy KW - Valproic Acid -- adverse effects KW - Liver Function Tests KW - Valproic Acid -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72948134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=The+safety+of+valproic+acid+use+for+patients+with+hepatitis+C+infection.&rft.au=Felker%2C+Bradford+L%3BSloan%2C+Kevin+L%3BDominitz%2C+Jason+A%3BBarnes%2C+Robert+F&rft.aulast=Felker&rft.aufirst=Bradford&rft.date=2003-01-01&rft.volume=160&rft.issue=1&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-30 N1 - Date created - 2002-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol withdrawal in severe hypothyroidism. AN - 72947486; 12515842 JF - Psychosomatics AU - Lambert, Michael Tedford AD - University of Texas Southwestern Medical School at Dallas, Texas, USA. Michael.Lambert2@med.va.gov PY - 2003 SP - 79 EP - 81 VL - 44 IS - 1 SN - 0033-3182, 0033-3182 KW - Index Medicus KW - Diagnosis, Differential KW - Humans KW - Middle Aged KW - Female KW - Alcohol Withdrawal Delirium -- diagnosis KW - Hypothyroidism -- diagnosis KW - Hypothyroidism -- complications KW - Alcohol Withdrawal Delirium -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72947486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatics&rft.atitle=Alcohol+withdrawal+in+severe+hypothyroidism.&rft.au=Lambert%2C+Michael+Tedford&rft.aulast=Lambert&rft.aufirst=Michael&rft.date=2003-01-01&rft.volume=44&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Psychosomatics&rft.issn=00333182&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-02-06 N1 - Date created - 2003-01-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Presumed teratoma-associated paraneoplastic retinopathy. AN - 72947343; 12523906 JF - Archives of ophthalmology (Chicago, Ill. : 1960) AU - Suhler, Eric B AU - Chan, Chi-Chao AU - Caruso, Rafael C AU - Schrump, David S AU - Thirkill, Charles AU - Smith, Janine A AU - Nussenblatt, Robert B AU - Buggage, Ronald R AD - eric.suhler@med.va.gov Y1 - 2003/01// PY - 2003 DA - January 2003 SP - 133 EP - 137 VL - 121 IS - 1 SN - 0003-9950, 0003-9950 KW - Arrestin KW - 0 KW - Autoantigens KW - Abridged Index Medicus KW - Index Medicus KW - Autoantigens -- blood KW - Humans KW - Arrestin -- immunology KW - Adult KW - Tomography, X-Ray Computed KW - Visual Fields KW - Female KW - Electroretinography KW - Retinal Diseases -- surgery KW - Retinal Diseases -- diagnosis KW - Teratoma -- complications KW - Paraneoplastic Syndromes -- etiology KW - Paraneoplastic Syndromes -- surgery KW - Paraneoplastic Syndromes -- diagnosis KW - Mediastinal Neoplasms -- complications KW - Retinal Diseases -- etiology KW - Mediastinal Neoplasms -- diagnostic imaging KW - Teratoma -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72947343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+ophthalmology+%28Chicago%2C+Ill.+%3A+1960%29&rft.atitle=Presumed+teratoma-associated+paraneoplastic+retinopathy.&rft.au=Suhler%2C+Eric+B%3BChan%2C+Chi-Chao%3BCaruso%2C+Rafael+C%3BSchrump%2C+David+S%3BThirkill%2C+Charles%3BSmith%2C+Janine+A%3BNussenblatt%2C+Robert+B%3BBuggage%2C+Ronald+R&rft.aulast=Suhler&rft.aufirst=Eric&rft.date=2003-01-01&rft.volume=121&rft.issue=1&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Archives+of+ophthalmology+%28Chicago%2C+Ill.+%3A+1960%29&rft.issn=00039950&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-23 N1 - Date created - 2003-01-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Combination antipsychotic therapy in clinical practice. AN - 72942134; 12509667 AB - Surveys have shown that antipsychotic drug combinations are frequently prescribed, yet few clinical studies have examined this practice. Experts have generally recommended antipsychotic combinations, especially those combining an atypical and a conventional antipsychotic, as a measure of last resort. A survey of prescribers was conducted to examine why combination antipsychotic therapy is being used in outpatient clinical practice. Antipsychotic prescribing practices in the Department of Veterans Affairs Puget Sound Health System were reviewed for a six-month period during 1998-1999. Data on the use of atypical and conventional antipsychotics in combination were collected. A total of 1,794 patients received prescriptions for at least one antipsychotic medication during the study period, of which 715 (40 percent) received an atypical agent. Ninety-three patients (13 percent) who were treated with an atypical antipsychotic received a prescription for combination antipsychotic therapy for at least 30 days. In cases in which both a conventional and an atypical agent were prescribed, the primary reason given for adding a conventional antipsychotic medication was to treat persistent positive symptoms. The primary reason an atypical agent was added to a conventional agent was to switch medications to the atypical agent; however, a significant number of patients became "stuck" on the combination. The results of this study support previous reports of the frequent use of combination antipsychotic therapy in clinical practice. Prospective controlled trials are needed to substantiate perceptions that combination antipsychotic therapy is clinically beneficial and to provide guidelines on when and for whom antipsychotic polypharmacy should be considered. JF - Psychiatric services (Washington, D.C.) AU - Tapp, Andre AU - Wood, Amanda Ernst AU - Secrest, Lori AU - Erdmann, Jaime AU - Cubberley, Lindy AU - Kilzieh, Nael AD - Department of Veterans Affairs Puget Sound Health Care System, Tacoma, Washington 98493, USA. tapp.andre@seattle.va.gov Y1 - 2003/01// PY - 2003 DA - January 2003 SP - 55 EP - 59 VL - 54 IS - 1 SN - 1075-2730, 1075-2730 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Combined Modality Therapy KW - Humans KW - Adult KW - Male KW - Female KW - Drug Prescriptions -- statistics & numerical data KW - Practice Patterns, Physicians' KW - Mental Disorders -- therapy KW - Mental Disorders -- drug therapy KW - Antipsychotic Agents -- therapeutic use KW - Psychotherapy -- methods KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72942134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Combination+antipsychotic+therapy+in+clinical+practice.&rft.au=Tapp%2C+Andre%3BWood%2C+Amanda+Ernst%3BSecrest%2C+Lori%3BErdmann%2C+Jaime%3BCubberley%2C+Lindy%3BKilzieh%2C+Nael&rft.aulast=Tapp&rft.aufirst=Andre&rft.date=2003-01-01&rft.volume=54&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-23 N1 - Date created - 2003-01-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Psychiatr Serv. 2003 Apr;54(4):574; author reply 574 [12663851] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of divalproex combined with olanzapine or risperidone in patients with an acute exacerbation of schizophrenia. AN - 72894471; 12496955 AB - This double-blind, randomized, multicenter study investigated the use of divalproex with an antipsychotic agent in patients hospitalized for acute exacerbation of schizophrenia. Patients (n = 249) who met DSM-IV criteria for schizophrenia were randomly assigned to receive olanzapine monotherapy, risperidone monotherapy, divalproex plus olanzapine, or divalproex plus risperidone for 28 days. Divalproex was initiated at 15 mg/kg/day and titrated over 12 days to a maximum dosage of 30 mg/kg/day. Olanzapine and risperidone, were, respectively, initiated at 5 and 2 mg/day and were titrated over the first 6 days to respective target fixed daily dosages of 15 and 6 mg/day. Improvements from baseline were observed at all evaluation points throughout the 28-day treatment period in the two combination therapy and the two antipsychotic monotherapy groups, with statistically significant treatment differences favoring combination therapy as soon as day 3 for Positive and Negative Syndrome Scale (PANSS) total score, derived Brief Psychiatric Rating Scale (BPRSd) total score, as well as PANSS and BPRSd subscales. These findings were confirmed in post hoc repeated-measures analyses of variance in which treatment differences favoring combination therapy were observed for PANSS total (p = 0.020) and PANSS positive scale scores (p = 0.002). Both combination therapy and antipsychotic monotherapy were well tolerated. Treatment with divalproex in combination with an atypical antipsychotic agent resulted in earlier improvements in a range of psychotic symptoms among acutely hospitalized patients with schizophrenia. Further evaluation is warranted to confirm these findings. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Casey, Daniel E AU - Daniel, David G AU - Wassef, Adel A AU - Tracy, Katherine A AU - Wozniak, Patricia AU - Sommerville, Kenneth W AD - Mental Illness Research, Education, and Clinical Center, Portland VA Medical Center, OR 97201, USA. daniel.casey@med.va.gov Y1 - 2003/01// PY - 2003 DA - January 2003 SP - 182 EP - 192 VL - 28 IS - 1 SN - 0893-133X, 0893-133X KW - Antimanic Agents KW - 0 KW - Antipsychotic Agents KW - Benzodiazepines KW - 12794-10-4 KW - Pirenzepine KW - 3G0285N20N KW - Valproic Acid KW - 614OI1Z5WI KW - Risperidone KW - L6UH7ZF8HC KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - Drug Therapy, Combination KW - Psychiatric Status Rating Scales KW - Double-Blind Method KW - Humans KW - Adult KW - Schizophrenic Psychology KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Pirenzepine -- analogs & derivatives KW - Antipsychotic Agents -- therapeutic use KW - Antimanic Agents -- adverse effects KW - Antimanic Agents -- therapeutic use KW - Valproic Acid -- adverse effects KW - Schizophrenia -- drug therapy KW - Risperidone -- adverse effects KW - Valproic Acid -- therapeutic use KW - Antipsychotic Agents -- adverse effects KW - Risperidone -- therapeutic use KW - Pirenzepine -- therapeutic use KW - Pirenzepine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72894471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Effect+of+divalproex+combined+with+olanzapine+or+risperidone+in+patients+with+an+acute+exacerbation+of+schizophrenia.&rft.au=Casey%2C+Daniel+E%3BDaniel%2C+David+G%3BWassef%2C+Adel+A%3BTracy%2C+Katherine+A%3BWozniak%2C+Patricia%3BSommerville%2C+Kenneth+W&rft.aulast=Casey&rft.aufirst=Daniel&rft.date=2003-01-01&rft.volume=28&rft.issue=1&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-17 N1 - Date created - 2002-12-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Neuropsychopharmacology. 2003 Nov;28(11):2049; author reply 2052-3 [12968130] Neuropsychopharmacology. 2004 Mar;29(3):636; author reply 637-8 [14973433] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fructose diphosphate attenuates the acetaminophen-induced liver injury in the rat evidence for involvement of nitric oxide. AN - 71599687; 15686124 AB - We have previously shown that fructose-1,6-diphosphate (FDP) stimulates the synthesis of nitric oxide probably by stimulating the hepatic inducible nitric oxide synthase (iNOS). The aim of the present study was to evaluate the hepatoprotective role of FDP in acetaminophen-induced liver injury and whether this hepatoprotective effect is mediated by nitric oxide. Liver injury was induced in adult Sprague-Dawley rats by the administration of acetaminophen (1.6 g/kg by gavage) 10 min prior to the intraperitoneal injection of either FDP or normal saline. Liver injury was assessed by alanine aminotransferase (ALT) activity in the serum. iNOS and malondialdehyde (MDA) levels were determined in liver homogenates. Acetaminophen produced striking elevations of serum ALT, high MDA levels and a profound decrease in the liver iNOS. Administration of FDP attenuated the ALT and MDA elevations and prevented the liver iNOS depletion caused by acetaminophen. Pretreatment of the animals with the iNOS inhibitor L-NAME abolished this hepatoprotection. These findings suggest that FDP protects against acetaminophen-induced liver injury, at least partly, by stimulating production of nitric oxide. JF - Research communications in molecular pathology and pharmacology AU - Mihas, Anastasios A AU - Kanji, Vijaya K AU - Mihas, Thanos A AU - Joseph, Roy M AU - Markov, Angel K AU - Heuman, Douglas M AD - Department Of Medicine, University Of Mississippi Medical Center Jackson, Mississippi, USA. anastasios.mihas2@med.va.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 253 EP - 266 VL - 113-114 SN - 1078-0297, 1078-0297 KW - Analgesics, Non-Narcotic KW - 0 KW - Fructosediphosphates KW - Nitric Oxide KW - 31C4KY9ESH KW - Acetaminophen KW - 362O9ITL9D KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Nitric Oxide Synthase Type II KW - Nos2 protein, rat KW - Alanine Transaminase KW - EC 2.6.1.2 KW - fructose-1,6-diphosphate KW - M7522JYX1H KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Alanine Transaminase -- blood KW - Male KW - Chemical and Drug Induced Liver Injury -- prevention & control KW - Analgesics, Non-Narcotic -- antagonists & inhibitors KW - Analgesics, Non-Narcotic -- toxicity KW - Nitric Oxide -- physiology KW - Acetaminophen -- antagonists & inhibitors KW - Nitric Oxide Synthase -- metabolism KW - Fructosediphosphates -- therapeutic use KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Chemical and Drug Induced Liver Injury -- enzymology KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71599687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+communications+in+molecular+pathology+and+pharmacology&rft.atitle=Fructose+diphosphate+attenuates+the+acetaminophen-induced+liver+injury+in+the+rat+evidence+for+involvement+of+nitric+oxide.&rft.au=Mihas%2C+Anastasios+A%3BKanji%2C+Vijaya+K%3BMihas%2C+Thanos+A%3BJoseph%2C+Roy+M%3BMarkov%2C+Angel+K%3BHeuman%2C+Douglas+M&rft.aulast=Mihas&rft.aufirst=Anastasios&rft.date=2003-01-01&rft.volume=113-114&rft.issue=&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Research+communications+in+molecular+pathology+and+pharmacology&rft.issn=10780297&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-03-02 N1 - Date created - 2005-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The nob mutation does not protect against light-induced retinal degeneration. AN - 71578246; 15180280 JF - Advances in experimental medicine and biology AU - Pardue, Machelle T AU - Grimm, Christian AU - Wenzel, Andreas AU - Remé, Charlotte E AD - Rehab R&D, Atlanta VA Medical Center, Decatur, GA 30033, USA. machelle.pardue@med.va.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 327 EP - 330 VL - 533 SN - 0065-2598, 0065-2598 KW - NYX protein, human KW - 0 KW - Proteoglycans KW - Index Medicus KW - Animals KW - Mice, Mutant Strains KW - Mice, Inbred C57BL KW - Mice KW - Genetic Predisposition to Disease KW - Mice, Inbred BALB C KW - Radiation Injuries -- complications KW - Male KW - Female KW - Retinal Degeneration -- prevention & control KW - Light -- adverse effects KW - Proteoglycans -- genetics KW - Retinal Degeneration -- etiology KW - Mutation KW - Retinal Degeneration -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71578246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=The+nob+mutation+does+not+protect+against+light-induced+retinal+degeneration.&rft.au=Pardue%2C+Machelle+T%3BGrimm%2C+Christian%3BWenzel%2C+Andreas%3BRem%C3%A9%2C+Charlotte+E&rft.aulast=Pardue&rft.aufirst=Machelle&rft.date=2003-01-01&rft.volume=533&rft.issue=&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-04 N1 - Date created - 2004-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Spider Bites Presenting with Methicillin-Resistant Staphylococcus aureus Soft Tissue Infection Require Early Aggressive Treatment. AN - 71557863; 15012857 AB - Occasionally, spider bites result in necrotizing soft tissue infections that require aggressive surgical debridement and treatment with intravenous antibiotics. With the rise of microbial resistance in the community, management with standard gram-positive intravenous antibiotic coverage may be ineffective. Our objective was to determine the infectious organisms cultured following wide local excision of soft tissue infections caused by spider bites. We hypothesized that the majority of isolated organisms would be sensitive to penicillin based antibiotics. From March 2000 to November 2001, the medical records were reviewed of patients who presented to a tertiary care hospital with serious soft tissue infections secondary to spider bites that required surgical treatment. For each patient, demographics, symptoms, size, time to surgical evaluation (TTSE), temperature, white blood cell (WBC) count, surgical procedure, and culture data were collected. Data are presented as mean +/- SEM. Thirty-eight patients presented with serious soft tissue infections secondary to spider bites that required surgical debridement and treatment with intravenous antibiotics. Twenty-nine percent (11 of 38) of these patients had failed initial outpatient therapy with penicillin-based oral antibiotics. The mean TTSE was 5.0 +/- 0.5 days (range = 2-14 days; median = 4.5 days). The most common presenting symptoms were pain and erythema surrounding the bite site. The mean temperature was 98.8 +/- 0.6 degrees F (range = 97.2-102.2 degrees F; median = 99.2 degrees F). The mean WBC count was 12.6 +/- 0.8 mm3. All patients required wide surgical debridement of the infected area. The mean size of the excised tissue was 26 +/- 4 cm2 (range = 4-120 cm2; median = 16 cm2). Every patient had cultures that grew Staphylococcus aureus. In 86.8% of patients, S. aureus was found to be methicillin-resistant (MRSA). All isolated organisms were sensitive to trimethoprim-sulfamethoxazole. In our experience, patients who presented with soft tissue infections as result of spider bites predominantly had methicillin-resistant S. aureus infections, corresponding to the increased incidence of MRSA reported in the community. Therefore, a more aggressive approach to the management of spider bites presenting with severe cellulitis is warranted. Routine treatment should include aggressive surgical debridement, intraoperative wound cultures, the empiric use of antibiotics with activity against MRSA, and adjustment of antimicrobial therapy based on culture and sensitivity data. JF - Surgical infections AU - Fagan, Shawn P AU - Berger, David H AU - Rahwan, Khalil AU - Awad, Samir S AD - Houston Veterans Affairs Medical Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77054, USA. Shawn.P.Fagan@med.va.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 311 EP - 315 VL - 4 IS - 4 SN - 1096-2964, 1096-2964 KW - Anti-Bacterial Agents KW - 0 KW - Index Medicus KW - Anti-Bacterial Agents -- therapeutic use KW - Humans KW - Retrospective Studies KW - Debridement KW - Time Factors KW - Staphylococcal Infections -- therapy KW - Spider Bites -- microbiology KW - Staphylococcus aureus -- isolation & purification KW - Soft Tissue Infections -- microbiology KW - Spider Bites -- complications KW - Methicillin Resistance KW - Staphylococcal Infections -- etiology KW - Spider Bites -- therapy KW - Soft Tissue Infections -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71557863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Surgical+infections&rft.atitle=Spider+Bites+Presenting+with+Methicillin-Resistant+Staphylococcus+aureus+Soft+Tissue+Infection+Require+Early+Aggressive+Treatment.&rft.au=Fagan%2C+Shawn+P%3BBerger%2C+David+H%3BRahwan%2C+Khalil%3BAwad%2C+Samir+S&rft.aulast=Fagan&rft.aufirst=Shawn&rft.date=2003-01-01&rft.volume=4&rft.issue=4&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Surgical+infections&rft.issn=10962964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-20 N1 - Date created - 2004-03-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Surg Infect (Larchmt). 2004 Fall;5(3):321-2; author reply 322 [15684805] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunoneutralization of procalcitonin as therapy of sepsis. AN - 71518966; 14733723 AB - Prior studies have demonstrated that the prohormone, procalcitonin (ProCT), and its component calcitonin precursors (CTpr) are increased in the serum of septic patients, correlate with the severity of the illness, and persist for relatively long periods of time. Animal studies in septic hamsters have revealed that the administration of ProCT is toxic and that immunoneutralization with IgG that is reactive to this molecule significantly improves survival. A large animal model of a very rapidly lethal polymicrobial sepsis has been developed in the pig in order to measure continuous physiological and metabolic parameters and also to compare the effects in this animal of an immunoneutralization, which is performed late in the course of the disease, to an identical, but early, therapy. Based upon the physiological and metabolic parameters, the late therapy, which was initiated during the fourth hour at a time when pigs were nearly moribund, was found to be as beneficial as early therapy. In both late and early therapy, the only animals to survive at the predetermined time of euthanasia were those which had received immunoneutralization therapy. JF - Journal of endotoxin research AU - Becker, K L AU - Nylén, E S AU - Snider, R H AU - Müller, B AU - White, J C AD - George Washington University and Veterans Administration Medical Center, 50 Irving Street NW, Washington, DC 20422, USA. klb1@erols.com Y1 - 2003 PY - 2003 DA - 2003 SP - 367 EP - 374 VL - 9 IS - 6 SN - 0968-0519, 0968-0519 KW - Immunoglobulin G KW - 0 KW - Protein Precursors KW - Calcitonin KW - 9007-12-9 KW - Index Medicus KW - Swine KW - Animals KW - Mesocricetus KW - Time Factors KW - Cricetinae KW - Sepsis -- immunology KW - Calcitonin -- toxicity KW - Calcitonin -- immunology KW - Protein Precursors -- genetics KW - Sepsis -- physiopathology KW - Calcitonin -- blood KW - Protein Precursors -- secretion KW - Sepsis -- therapy KW - Calcitonin -- secretion KW - Immunoglobulin G -- immunology KW - Immunoglobulin G -- administration & dosage KW - Protein Precursors -- toxicity KW - Protein Precursors -- immunology KW - Sepsis -- mortality KW - Sepsis -- blood KW - Calcitonin -- genetics KW - Protein Precursors -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71518966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+endotoxin+research&rft.atitle=Immunoneutralization+of+procalcitonin+as+therapy+of+sepsis.&rft.au=Becker%2C+K+L%3BNyl%C3%A9n%2C+E+S%3BSnider%2C+R+H%3BM%C3%BCller%2C+B%3BWhite%2C+J+C&rft.aulast=Becker&rft.aufirst=K&rft.date=2003-01-01&rft.volume=9&rft.issue=6&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Journal+of+endotoxin+research&rft.issn=09680519&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-08-16 N1 - Date created - 2004-01-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Critical gaps in the world's largest electronic medical record: Ad Hoc nursing narratives and invisible adverse drug events. AN - 71506000; 14728184 AB - The Veterans Health Administration (VHA), of the U.S. Department of Veteran Affairs, operates one of the largest healthcare networks in the world. Its electronic medical record (EMR) is fully integrated into clinical practice, having evolved over several decades of design, testing, trial, and error. It is unarguably the world's largest EMR, and as such it makes an important case study for a host of timely informatics issues. The VHA consistently has been at the vanguard of patient safety, especially in its provider-oriented EMR. We describe here a study of a large set of adverse drug events (ADEs) that eluded a rigorous ADE survey based on prospective EMR chart review. These numerous ADEs were undetected (and hence invisible) in the EMR, missed by an otherwise sophisticated ADE detection scheme. We speculate how these invisible nursing ADE narratives persist and what they portend for safety re-engineering. JF - AMIA ... Annual Symposium proceedings. AMIA Symposium AU - Hurdle, John F AU - Weir, Charlene R AU - Roth, Beverly AU - Hoffman, Jennifer AU - Nebeker, Jonathan R AD - Veterans Administration SLC Healthcare System Geriatrics Research, Education, and Care Center (GRECC), Salt Lake City, UT, USA. Y1 - 2003 PY - 2003 DA - 2003 SP - 309 EP - 312 KW - Index Medicus KW - United States KW - Clinical Pharmacy Information Systems KW - United States Department of Veterans Affairs KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Risk Management KW - Medical Audit KW - Hospitals, Veterans KW - Medical Records Systems, Computerized KW - Adverse Drug Reaction Reporting Systems KW - Narration KW - Nursing Records UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71506000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AMIA+...+Annual+Symposium+proceedings.+AMIA+Symposium&rft.atitle=Critical+gaps+in+the+world%27s+largest+electronic+medical+record%3A+Ad+Hoc+nursing+narratives+and+invisible+adverse+drug+events.&rft.au=Hurdle%2C+John+F%3BWeir%2C+Charlene+R%3BRoth%2C+Beverly%3BHoffman%2C+Jennifer%3BNebeker%2C+Jonathan+R&rft.aulast=Hurdle&rft.aufirst=John&rft.date=2003-01-01&rft.volume=&rft.issue=&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=AMIA+...+Annual+Symposium+proceedings.+AMIA+Symposium&rft.issn=1942-597X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-14 N1 - Date created - 2004-01-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Nurs Care Qual. 2000 Oct;15(1):42-8 [11008438] Pharm World Sci. 1999 Jun;21(3):110-5 [10427579] Methods Inf Med. 2003;42(1):61-7 [12695797] Am J Hosp Pharm. 1990 Jun;47(6):1334-9 [2368727] JAMA. 1991 Nov 27;266(20):2847-51 [1942452] J Gen Intern Med. 1993 Jun;8(6):289-94 [8320571] BMJ. 1993 Aug 21;307(6902):480-1 [8400931] JAMA. 1995 Jul 5;274(1):29-34 [7791255] Jt Comm J Qual Improv. 1995 Oct;21(10):541-8 [8556111] Am J Health Syst Pharm. 1996 Jan 15;53(2):178-81 [8653485] Am J Health Syst Pharm. 1996 Feb 1;53(3):314-5 [8808031] Br J Clin Pharmacol. 1998 Mar;45(3):301-8 [9517375] J Am Med Inform Assoc. 1998 May-Jun;5(3):305-14 [9609500] Eur J Clin Pharmacol. 1999 Jan;54(11):887-92 [10027665] Lancet. 2000 Oct 7;356(9237):1255-9 [11072960] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Timing of alcohol and smoking cessation (TASC): smoking among substance use patients screened and enrolled in a clinical trial. AN - 71501763; 14723480 AB - Tobacco dependence is prevalent among alcohol dependent patients, and causes increased morbidity and mortality. Concurrent treatment for these disorders may be advantageous, but there are concerns about adverse effects on alcohol treatment outcomes. The Timing of Alcohol and Smoking Cessation (TASC) Study is a randomized controlled clinical trial to compare the effectiveness of smoking cessation treatment offered concurrently or six months following intensive rehabilitation for alcohol dependence. This paper describes the study design and baseline characteristics of the study population. Participants were current smokers in intensive alcohol dependence treatment, with willingness to consider quitting smoking. Smoking intervention offered behavioral and pharmacological treatment. One thousand nine hundred forty-three patients were screened for enrollment; 499 were eligible and participated (26%). We describe demographic characteristics, smoking behavior and attitudes among participants and nonparticipants toward smoking cessation and drinking. We conclude that there is considerable interest in smoking cessation in alcohol dependent treatment populations, and recruitment to research studies is feasible. JF - Journal of addictive diseases AU - Joseph, Anne M AU - Nelson, David B AU - Nugent, Sean M AU - Willenbring, Mark L AD - Center for Chronic Disease Outcomes Research, Minneapolis VA Medical Center, and the University of Minnesota, Minneapolis, MN, USA. Anne.M.Joseph@med.va.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 87 EP - 107 VL - 22 IS - 4 SN - 1055-0887, 1055-0887 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Nicotine -- therapeutic use KW - Minnesota KW - Administration, Cutaneous KW - Substance Abuse Treatment Centers KW - Humans KW - Adult KW - Behavior Therapy -- methods KW - Time Factors KW - Male KW - Female KW - Alcohol-Related Disorders -- complications KW - Tobacco Use Disorder -- therapy KW - Smoking Cessation -- methods KW - Alcohol-Related Disorders -- therapy KW - Tobacco Use Disorder -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71501763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+addictive+diseases&rft.atitle=Timing+of+alcohol+and+smoking+cessation+%28TASC%29%3A+smoking+among+substance+use+patients+screened+and+enrolled+in+a+clinical+trial.&rft.au=Joseph%2C+Anne+M%3BNelson%2C+David+B%3BNugent%2C+Sean+M%3BWillenbring%2C+Mark+L&rft.aulast=Joseph&rft.aufirst=Anne&rft.date=2003-01-01&rft.volume=22&rft.issue=4&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Journal+of+addictive+diseases&rft.issn=10550887&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-26 N1 - Date created - 2004-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - African American and Caucasian attempters compared for suicide risk factors: a preliminary study. AN - 71481822; 14695058 AB - The aim of the study was to compare African American and Caucasian substance dependent suicide attempters for risk factors for suicidal behavior. One hundred and fifty-eight African American and 95 Caucasian substance dependent patients who had attempted suicide were interviewed and their family history of suicidal behavior recorded. Patients completed the Childhood Trauma Questionnaire, the Eysenck Personality Questionnaire, and the Foulds Hostility and Direction of Hostility Questionnaire. The results revealed that there were no significant differences between the African American and Caucasian suicide attempters for marital status, age, childhood abuse, or for personality scores for neuroticism, extraversion, psychoticism, or hostility. However, the African American attempters had significantly lower childhood emotional neglect scores. Also, significantly more of the Caucasian attempters had a family history of suicide and current legal problems. Further studies seem warranted examining for differences between African Americans and Caucasians for risk factors for suicidal behavior. JF - Suicide & life-threatening behavior AU - Roy, Alec AD - Psychiatry Service (116A), Department of Veterans Affairs, New Jersey Healthcare System, 385 Tremont Avenue, East Orange, NJ 07018, USA. Alec.Roy@med.va.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 443 EP - 447 VL - 33 IS - 4 SN - 0363-0234, 0363-0234 KW - Index Medicus KW - New Jersey -- epidemiology KW - Risk Factors KW - Humans KW - Adult KW - Male KW - Female KW - Comorbidity KW - Suicide, Attempted -- statistics & numerical data KW - Suicide, Attempted -- psychology KW - African Americans -- psychology KW - European Continental Ancestry Group -- psychology KW - Suicide, Attempted -- ethnology KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71481822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Suicide+%26+life-threatening+behavior&rft.atitle=African+American+and+Caucasian+attempters+compared+for+suicide+risk+factors%3A+a+preliminary+study.&rft.au=Roy%2C+Alec&rft.aulast=Roy&rft.aufirst=Alec&rft.date=2003-01-01&rft.volume=33&rft.issue=4&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Suicide+%26+life-threatening+behavior&rft.issn=03630234&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-01 N1 - Date created - 2003-12-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sexual trauma, posttraumatic stress disorder, and health behavior. AN - 71445983; 14663922 AB - The authors tested whether sexual traumatization is associated with poorer health behavior and also evaluated the role of posttraumatic stress disorder (PTSD) in this relationship. They mailed questionnaires to 419 women who had visited a San Diego Veterans Administration primary care clinic in 1998 and received 221 responses, a 56% return rate. They found that a history of sexual assault was associated with increased substance use, risky sexual behaviors, less vigorous exercise, and increased preventive healthcare. They then used regression-based techniques to test whether PTSD mediates the relationship between a history of sexual assault and health behaviors and discovered support for this hypothesis in relation to substance use. PTSD symptoms were also associated with less likelihood of conducting regular breast self-examinations. Findings from the study highlight the value of programs designed to (1) identify trauma victims, (2) screen for problematic behaviors, and (3) intervene to improve long-term health outcomes. JF - Behavioral medicine (Washington, D.C.) AU - Lang, Ariel J AU - Rodgers, Carie S AU - Laffaye, Charlene AU - Satz, Leslie E AU - Dresselhaus, Timothy R AU - Stein, Murray B AD - Behavioral Medicine Service, Veterans Administration San Diego Healthcare System (VASDHS), USA. ajlang@ucsd.edu Y1 - 2003 PY - 2003 DA - 2003 SP - 150 EP - 158 VL - 28 IS - 4 SN - 0896-4289, 0896-4289 KW - Index Medicus KW - Substance-Related Disorders -- diagnosis KW - Risk-Taking KW - Aged, 80 and over KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Female KW - Substance-Related Disorders -- epidemiology KW - Rape -- psychology KW - Stress Disorders, Post-Traumatic -- etiology KW - Stress Disorders, Post-Traumatic -- psychology KW - Health Behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71445983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+medicine+%28Washington%2C+D.C.%29&rft.atitle=Sexual+trauma%2C+posttraumatic+stress+disorder%2C+and+health+behavior.&rft.au=Lang%2C+Ariel+J%3BRodgers%2C+Carie+S%3BLaffaye%2C+Charlene%3BSatz%2C+Leslie+E%3BDresselhaus%2C+Timothy+R%3BStein%2C+Murray+B&rft.aulast=Lang&rft.aufirst=Ariel&rft.date=2003-01-01&rft.volume=28&rft.issue=4&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Behavioral+medicine+%28Washington%2C+D.C.%29&rft.issn=08964289&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-25 N1 - Date created - 2003-12-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sleep respiratory concomitants of comorbid panic and nightmare complaint in post-traumatic stress disorder. AN - 71431351; 14661189 AB - Posttraumatic stress disorder (PTSD) patients with comorbid panic disorder (PD) may express additive symptoms of central fear system disturbance. They endorse elevated levels of sleep and nightmare disturbance [Leskin GA, et al., J Psychiatr Res 2002;36:449-452], and demonstrate movement suppression during laboratory sleep [Woodward SH, et al., Sleep 2002;25:681-688]. We estimated respiratory rate and rate variability separately for rapid-eye movement (REM) and non-rapid-eye movement (NREM) sleep. Subjects were 49 Vietnam combat-related PTSD inpatients (11 with comorbid PD and 38 without) and 15 controls. Computer-based estimates of respiratory rate and variability were derived from 10 to 18 hr of baseline sleep collected over two or three nights. Neither rate nor rate variability distinguished PTSD patients with comorbid PD from those without, or PTSD patients from controls; however, PTSD patients failed to exhibit the expected differences between REM and NREM respiratory rates. Moreover, the difference between REM and NREM respiratory rate was inversely related to a continuous measure of PTSD severity. PTSD patients with trauma-related nightmare complaint exhibited higher sleep respiration rates over both REM and NREM sleep. Conversely, in addition to slowed respiration, nightmare-free patients exhibited reduced respiratory rate variability in REM relative to NREM sleep, which was a reversal of the normal pattern. These finding are discussed in light of known telencephalic regulatory influences upon respiration rate. JF - Depression and anxiety AU - Woodward, Steven H AU - Leskin, Gregory A AU - Sheikh, Javaid I AD - National Center for PTSD, Clinical Laboratory and Education Division, Veterans' Administration Palo Alto Health Care System, California, USA. Steve.woodward@med.va.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 198 EP - 204 VL - 18 IS - 4 SN - 1091-4269, 1091-4269 KW - Index Medicus KW - Substance-Related Disorders -- physiopathology KW - Depressive Disorder, Major -- diagnosis KW - Signal Processing, Computer-Assisted KW - Alcoholism -- diagnosis KW - Sleep, REM -- physiology KW - Humans KW - Arousal -- physiology KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Comorbidity KW - Vietnam KW - Cerebral Cortex -- physiopathology KW - Substance-Related Disorders -- diagnosis KW - Depressive Disorder, Major -- psychology KW - Adult KW - Middle Aged KW - Alcoholism -- physiopathology KW - Male KW - Depressive Disorder, Major -- physiopathology KW - Sleep Wake Disorders -- diagnosis KW - Polysomnography KW - Combat Disorders -- psychology KW - Respiration KW - Veterans -- psychology KW - Combat Disorders -- diagnosis KW - Sleep Wake Disorders -- psychology KW - Dreams -- physiology KW - Combat Disorders -- physiopathology KW - Sleep Wake Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71431351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+anxiety&rft.atitle=Sleep+respiratory+concomitants+of+comorbid+panic+and+nightmare+complaint+in+post-traumatic+stress+disorder.&rft.au=Woodward%2C+Steven+H%3BLeskin%2C+Gregory+A%3BSheikh%2C+Javaid+I&rft.aulast=Woodward&rft.aufirst=Steven&rft.date=2003-01-01&rft.volume=18&rft.issue=4&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=Depression+and+anxiety&rft.issn=10914269&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-07-07 N1 - Date created - 2003-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Constructing the Theoretical Foundation for Cross-Cultural Medical Ethics T2 - Society for the Study of Social Problems AN - 61782141; 2003S41312 AB - Ethics has proven to be a fertile source of laws, regulations, and guidelines for practitioners in a wide variety of professions. Yet within medicine, ethical standards that are particular to cultures are often more apparent than those that transcend cultures. Modern western medicine, however, seems able to generate a medical ethics that transcends cultures. The ethical universalist view holds that right action entails the universalizability of the principle that guides the action. Separate from universal human rights, based in ethics & the law, there are human values that are inherently universal. Modern medical ethics can serve as an encouraging example of international ethical dialogue directed toward creating universal ethical policies & concrete ethical standards for implementing bioethical principles, including respect for autonomy, nonmaleficence, beneficence, & justice. But in every instance a gap will exist between the universal ethical standards & the cultural circumstance or medical context in which these will be applied. Universal ethical principles are fundamental & yet will usually require some adjustment in order to be properly applied. Culture will never invalidate universal ethical principles or require that they be violated. Culture, however, will always require consideration for the way principles are applied via rules and norms. JF - Society for the Study of Social Problems AU - Rodriguez, Keri Lyn Y1 - 2003///0, PY - 2003 DA - 0, 2003 KW - Ethics KW - Bioethics KW - Cultural Universals KW - Human Rights KW - proceeding KW - 2499: policy, planning, forecasting; sociology of ethics & ethical decision making UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61782141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Society+for+the+Study+of+Social+Problems&rft.atitle=Constructing+the+Theoretical+Foundation+for+Cross-Cultural+Medical+Ethics&rft.au=Rodriguez%2C+Keri+Lyn&rft.aulast=Rodriguez&rft.aufirst=Keri&rft.date=2003-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Society+for+the+Study+of+Social+Problems&rft.issn=&rft_id=info:doi/ L2 - http://Pittsburgh, LA - English DB - Sociological Abstracts N1 - Date revised - 2009-03-10 N1 - Publication note - 2003 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Comparison of Consumption Effects of Brief Interventions for Hazardous Drinking Elderly AN - 61554548; 200400545 AB - We sought to determine if Brief Interventions (BIs, Motivational Enhancement (ME), & Brief Advice (BA)) reduced alcohol consumption among hazardous alcohol drinking elderly (65 years or older) & whether the elderly responded similarly to younger populations. In 12 primary care offices from Oct 1995 to Dec 1997, we screened 13,438 patients of whom 2,702 were elderly (180 were hazardous drinkers). Forty-five elderly enrollees were randomized to receive ME (n = 18), BA (n = 12), & Standard Care (SC, n = 12). At baseline, the elderly drank more alcohol & abstained fewer days than the younger cohort (p0.05). During the year, the elderly in ME, BA, & SC intervention arms increased the number of days abstained, decreased the number of drinks per day, & reduced the number of total days per month drinking. There were trends toward decreases in the alcohol consumption measures in the ME & BA treatment arms compared to SC. The elderly's response to all interventions was similar to that of the younger cohort. This study suggests that hazardous alcohol consumption in the elderly is common & that BIs reduce alcohol consumption in the elderly similar to younger populations. 2 Tables, 45 References. Adapted from the source document. JF - Substance Use & Misuse AU - Gordon, Adam J AU - Conigliaro, Joseph AU - Maisto, Stephen A AU - McNeil, Melissa AU - Kraemer, Kevin L AU - Kelley, Mary E AD - Center Health Equity Research & Promotion, VA Pittsburgh Healthcare System, Section General Internal Medicine, PA adam.gordon@med.va.gov Y1 - 2003///0, PY - 2003 DA - 0, 2003 SP - 1017 EP - 1035 VL - 38 IS - 8 SN - 1082-6084, 1082-6084 KW - Alcohol Abuse KW - Treatment Programs KW - Drinking Behavior KW - Elderly KW - Intervention KW - Counseling KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61554548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Substance+Use+%26+Misuse&rft.atitle=Comparison+of+Consumption+Effects+of+Brief+Interventions+for+Hazardous+Drinking+Elderly&rft.au=Gordon%2C+Adam+J%3BConigliaro%2C+Joseph%3BMaisto%2C+Stephen+A%3BMcNeil%2C+Melissa%3BKraemer%2C+Kevin+L%3BKelley%2C+Mary+E&rft.aulast=Gordon&rft.aufirst=Adam&rft.date=2003-01-01&rft.volume=38&rft.issue=8&rft.spage=1017&rft.isbn=&rft.btitle=&rft.title=Substance+Use+%26+Misuse&rft.issn=10826084&rft_id=info:doi/10.1081%2FJA-120017649 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Number of references - 45 N1 - Last updated - 2016-09-28 N1 - CODEN - SUMIFL N1 - SubjectsTermNotLitGenreText - Elderly; Drinking Behavior; Alcohol Abuse; Intervention; Counseling; Treatment Programs DO - http://dx.doi.org/10.1081/JA-120017649 ER - TY - JOUR T1 - Determinants of Behavioral Symptoms in Dementia Patients AN - 61500410; 200400121 AB - Behavioral symptoms in dementia are common, & lack of a conceptual model has resulted in the use of treatments that address only the symptoms & not the causes. Our conceptual model proposes that the determinants of behavioral symptoms derive from three sources, the patient, the caregiver, & the environment. These determinants are subdivided into those that are mutable & those that are fixed. By identifying mutable determinants, this conceptual model eventually will lead to a more systematic approach to the treatment of behavioral symptoms in dementia & to quality improvement programs. 1 Figure, 9 References. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Clinical Gerontologist AU - Kunik, Mark E AU - Martinez, Melissa AU - Snow, A Lynn AU - Beck, Cornelia K AU - Cody, Marisue AU - Rapp, Carla Gene AU - Molinari, Victor A AU - Orengo, Claudia A AU - Hamilton, Joseph DeVance AD - Houston Center Quality Care & Utilization Studies, Houston Veterans Administration Medical Center, TX mkunik@bcm.tmc.edu Y1 - 2003///0, PY - 2003 DA - 0, 2003 SP - 83 EP - 89 VL - 26 IS - 3-4 SN - 0731-7115, 0731-7115 KW - Symptoms KW - Senility KW - Behavior Problems KW - Models KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61500410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Gerontologist&rft.atitle=Determinants+of+Behavioral+Symptoms+in+Dementia+Patients&rft.au=Kunik%2C+Mark+E%3BMartinez%2C+Melissa%3BSnow%2C+A+Lynn%3BBeck%2C+Cornelia+K%3BCody%2C+Marisue%3BRapp%2C+Carla+Gene%3BMolinari%2C+Victor+A%3BOrengo%2C+Claudia+A%3BHamilton%2C+Joseph+DeVance&rft.aulast=Kunik&rft.aufirst=Mark&rft.date=2003-01-01&rft.volume=26&rft.issue=3-4&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Clinical+Gerontologist&rft.issn=07317115&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Number of references - 9 N1 - Last updated - 2016-09-28 N1 - CODEN - CLGEDA N1 - SubjectsTermNotLitGenreText - Senility; Symptoms; Models; Behavior Problems ER - TY - JOUR T1 - Eating Disorders among Urban and Rural African American and European American Women AN - 60471649; 200402766 AB - It is alleged that eating disorders are nonexistent in African American women & that eating disorder symptomatology occurs predominantly among White middle class women (Kumanyika, Wilson, & Guilford-Davenport, 1993; Smolak & Striegel-Moore, 2001). This research attempted to identify differences in eating disorder symptomatology in African American & White American women. An eating disorder is a disability because it can damage the person physically, emotionally, & socially. It can be undetected for years & society may reinforce the hidden disorder by being complimentary regarding the thin appearance of the person. The Eating Disorder Inventory (EDI) was used to measure psychological traits & symptom clusters associated with the understanding & treatment of eating disorders (Garner, 1990). Measures of self-esteem, depression, & coping were also examined. Findings indicated differences between African American & White women on the Ineffectiveness scale of the EDI, differences between the urban/rural women on Ineffectiveness & Perfectionism, & differences in coping strategies & education among this sample group of women. Successful treatment usually involves psychotherapy &/or medication for depression. 3 Tables, 40 References. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Women & Therapy AU - Bagley, Cherie A AU - Character, Colleen D AU - Shelton, Lisamarie AD - Louis Stokes Cleveland Dept Veterans Affairs Medical Center, Brecksville, OH bagley6.cherie@cleveland.va.gov Y1 - 2003///0, PY - 2003 DA - 0, 2003 SP - 57 EP - 79 VL - 26 IS - 1-2 SN - 0270-3149, 0270-3149 KW - Whites KW - Black White Differences KW - Black Americans KW - Self Esteem KW - Rural Urban Differences KW - Depression (Psychology) KW - Females KW - Atlanta, Georgia KW - Coping KW - Iowa KW - Eating Disorders KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60471649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women+%26+Therapy&rft.atitle=Eating+Disorders+among+Urban+and+Rural+African+American+and+European+American+Women&rft.au=Bagley%2C+Cherie+A%3BCharacter%2C+Colleen+D%3BShelton%2C+Lisamarie&rft.aulast=Bagley&rft.aufirst=Cherie&rft.date=2003-01-01&rft.volume=26&rft.issue=1-2&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Women+%26+Therapy&rft.issn=02703149&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - WOTHDJ N1 - SubjectsTermNotLitGenreText - Eating Disorders; Black Americans; Females; Whites; Black White Differences; Rural Urban Differences; Coping; Self Esteem; Depression (Psychology); Atlanta, Georgia; Iowa ER - TY - JOUR T1 - Predictive modeling for the presence of prostate carcinoma using clinical, laboratory, and ultrasound parameters in patients with prostate specific antigen levels <= 10 ng/mL AN - 20226201; 5727138 AB - The objective of the current study was to develop a model for predicting the presence of prostate carcinoma using clinical, laboratory, and transrectal ultrasound (TRUS) data. Data were collected on 1237 referred men with serum prostate specific antigen (PSA) levels 10% was used to indicate the presence of prostate carcinoma. The area under the receiver operating characteristic curve (AUC) for the model was 73%, which was significantly higher compared with the prediction based on PSA alone (AUC, 62%). If it was validated externally, then application of this model to the biopsy decision could result in a 24% reduction in unnecessary biopsy procedures, with an overall reduction of 20%. Incorporation of clinical, laboratory, and TRUS data into a prebiopsy nomogram significantly improved the prediction of prostate carcinoma over the use of individual factors alone. Predictive nomograms may serve as an aid to patient counseling regarding prostate biopsy outcome and to reduce the number of unnecessary biopsy procedures. JF - Cancer AU - Garzotto, M AU - Hudson, R G AU - Peters, L AU - Hsieh, Y-C AU - Barrera, E AU - Mori, M AU - Beer, T M AU - Klein, T AD - Division of Urology, Portland Veterans Administration Medical Center, Portland, Oregon, garzotto@ohsu.edu Y1 - 2003 PY - 2003 DA - 2003 SP - 1417 EP - 1422 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 98 IS - 7 SN - 0008-543X, 0008-543X KW - Biotechnology and Bioengineering Abstracts KW - prostate carcinoma KW - detection KW - prediction KW - nomogram KW - Risk assessment KW - Age KW - Data processing KW - Rectum KW - Regression analysis KW - Biopsy KW - Ultrasound KW - Races KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20226201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Predictive+modeling+for+the+presence+of+prostate+carcinoma+using+clinical%2C+laboratory%2C+and+ultrasound+parameters+in+patients+with+prostate+specific+antigen+levels+%26lt%3B%3D+10+ng%2FmL&rft.au=Garzotto%2C+M%3BHudson%2C+R+G%3BPeters%2C+L%3BHsieh%2C+Y-C%3BBarrera%2C+E%3BMori%2C+M%3BBeer%2C+T+M%3BKlein%2C+T&rft.aulast=Garzotto&rft.aufirst=M&rft.date=2003-01-01&rft.volume=98&rft.issue=7&rft.spage=1417&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.11668 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; prostate carcinoma; Age; Rectum; Data processing; Regression analysis; Biopsy; Ultrasound; Races; Models DO - http://dx.doi.org/10.1002/cncr.11668 ER - TY - JOUR T1 - Efficacy of liposome-encapsulated ciprofloxacin compared with ciprofloxacin and ceftriaxone in a rat model of pneumococcal pneumonia AN - 18894679; 5763035 AB - Encapsulation of ciprofloxacin in sterically stabilized liposomes results in a prolonged circulation time and improved pharmacokinetics. Liposome-encapsulated ciprofloxacin was compared with conventional ciprofloxacin and ceftriaxone in a rat model of pneumococcal pneumonia. Male Sprague-Dawley rats were infected transtracheally with type 3 Streptococcus pneumoniae and then treated with intravenous ceftriaxone (100 mg/kg), ciprofloxacin (40 or 80 mg/kg) or liposomal ciprofloxacin (40 or 80 mg/kg) administered once or twice daily for 3 days. White blood counts, development of bacteraemia and mortality were measured for 10 days. Antibiotic concentrations in serum, lung lavage fluid and white blood cells recovered from lung lavage fluid were determined. Liposomal ciprofloxacin concentrations were significantly higher in serum and lavage fluid compared with conventional ciprofloxacin, resulting in greater area under the serum concentration-time curve and maximum serum concentration. Despite these higher concentrations, survival rates were similar between groups treated with equivalent doses of liposomal ciprofloxacin versus ciprofloxacin. When antibiotics were given once daily, ceftriaxone was more effective than either form of ciprofloxacin. JF - Journal of Antimicrobial Chemotherapy AU - Ellbogen, M H AU - Olsen, K M AU - Gentry-Nielsen, MJ AU - Preheim, L C AD - Infectious Diseases Section; Veterans Affairs Medical Center, 4101 Woohvorth Avenue, Omaha, NE68105, USA, laurel.preheim@med.va.gov Y1 - 2003/01// PY - 2003 DA - Jan 2003 SP - 83 EP - 91 VL - 51 IS - 1 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology KW - J 02855:Human Bacteriology: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18894679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Efficacy+of+liposome-encapsulated+ciprofloxacin+compared+with+ciprofloxacin+and+ceftriaxone+in+a+rat+model+of+pneumococcal+pneumonia&rft.au=Ellbogen%2C+M+H%3BOlsen%2C+K+M%3BGentry-Nielsen%2C+MJ%3BPreheim%2C+L+C&rft.aulast=Ellbogen&rft.aufirst=M&rft.date=2003-01-01&rft.volume=51&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Disability after clinical fracture in postmenopausal women with low bone density: the fracture intervention trial (FIT) AN - 18726146; 5611417 AB - Relatively little is known about outcomes following clinical osteoporotic fractures at nonhip, nonvertebral skeletal sites. To address this issue, we prospectively assessed post-fracture disability at multiple skeletal sites in a population of 909 older (aged 55-81 years), community-dwelling women with low femoral neck bone mineral density who had experienced a fracture while enrolled in the Fracture Intervention Trial (FIT). FIT is a randomized, double-masked, placebo-controlled trial that was designed to determine the effect of alendronate on fracture incidence, and the current study was conducted as a secondary analysis of FIT data. Following incident clinical fractures, FIT participants were followed prospectively for assessment of site-specific, fracture-related disability. Measures of disability were self-reported days hospitalized or confined to bed because of the fracture (`bed days') and days of reduced usual activities because of the fracture (`limited activity days'). Of fracture types evaluated, those of the hip resulted in the highest percentage of subjects with any bed days or limited activity days after fracture (94% with any bed days and 100% with any limited activity days), though the mean number of bed days and limited activity days appeared highest after lumbar vertebral fractures (25.8 mean bed days and 158.5 mean limited activity days). Substantial disability also was reported after fractures of thoracic vertebrae, humerus, distal forearm, ankle and foot. Within fracture types, post-fracture disability was highly variable, ranging from none to more than 6 months. JF - Osteoporosis International AU - Fink, HA AU - Ensrud, KE AU - Nelson, D B AU - Kerani, R P AU - Schreiner, P J AU - Zhao, Y AU - Cummings AU - Nevitt, M C AD - Medical Center, One Veterans Drive, Box 11G, Minneapolis, MN 55417, USA, howard.fink@med.va.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 69 EP - 76 VL - 14 IS - 1 SN - 0937-941X, 0937-941X KW - females KW - man KW - Physical Education Index; Calcium & Calcified Tissue Abstracts KW - PE 090:Sports Medicine & Exercise Sport Science KW - T 20031:Fractures and bone healing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18726146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Osteoporosis+International&rft.atitle=Disability+after+clinical+fracture+in+postmenopausal+women+with+low+bone+density%3A+the+fracture+intervention+trial+%28FIT%29&rft.au=Fink%2C+HA%3BEnsrud%2C+KE%3BNelson%2C+D+B%3BKerani%2C+R+P%3BSchreiner%2C+P+J%3BZhao%2C+Y%3BCummings%3BNevitt%2C+M+C&rft.aulast=Fink&rft.aufirst=HA&rft.date=2003-01-01&rft.volume=14&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Osteoporosis+International&rft.issn=0937941X&rft_id=info:doi/10.1007%2Fs00198-002-1314-y LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1007/s00198-002-1314-y ER - TY - JOUR T1 - Chronic ethanol treatment reduces the magnitude of hippocampal LTD in the adult rat AN - 17974455; 5915750 AB - Human alcoholics and animals that have received chronic ethanol treatment (CET) display memory deficits. Previous work in our laboratory has shown that CET produces damage to the hippocampus and a reduction in the magnitude of hippocampal long-term synaptic potentiation. In the present report we examined the effects of CET on hippocampal long-term depression (LTD). We used in vitro hippocampal slices to examine LTD after rats received 38-41 weeks of paired feeding on liquid diets containing ethanol or isocaloric sucrose. Stimulation delivered through electrodes in the CA3-CA1 Schaffer collateral pathway activated synaptic population responses in CA1. LTD of CA1 stratum radiatum evoked field potential slope was not induced by 900 single pulses at 1 Hz, but was elicited by 900 pulse pairs separated by 50 or 200 msec delivered at 1 Hz (pLFS50, pLFS200). LTD evoked by pLFS200, but not by pLFS50, was significantly reduced in slices from ethanol-treated rats. The N-methyl D- aspartate (NMDA) receptor antagonist 2-amino-5-phosphonopentanoic acid (AP5) (50 mu M) blocked LTD induced by pLFS50 and pLFS200 equally, but the L-type calcium channel blocker nimodipine (10 mu M) had no effect on either type of LTD. Thus, direct effects on these channels cannot explain how CET selectively reduces the magnitude of pLFS200 LTD. Finally, we describe a novel and robust LTD of the presynaptic afferent volley that is resistant to CET, NMDAR antagonists, GABA-A receptor blockade, and blockade of L-type calcium channels. JF - Synapse AU - Thinschmidt, J S AU - Walker, D W AU - King, MA AD - University of Florida McKnight Brain Institute and Veterans Administration Medical Center, Gainesville, Florida, tschmidt@ufbi.ufl.edu Y1 - 2003 PY - 2003 DA - 2003 SP - 189 EP - 197 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 48 IS - 4 SN - 0887-4476, 0887-4476 KW - rats KW - Toxicology Abstracts KW - Depression KW - Hippocampus KW - Brain KW - Long-term depression KW - Ethanol KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17974455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse&rft.atitle=Chronic+ethanol+treatment+reduces+the+magnitude+of+hippocampal+LTD+in+the+adult+rat&rft.au=Thinschmidt%2C+J+S%3BWalker%2C+D+W%3BKing%2C+MA&rft.aulast=Thinschmidt&rft.aufirst=J&rft.date=2003-01-01&rft.volume=48&rft.issue=4&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Synapse&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Long-term depression; Depression; Ethanol; Hippocampus; Brain ER - TY - JOUR T1 - A data review and re-assessment of ovarian cancer serum proteomic profiling AN - 17532324; 6234053 AB - Background: The early detection of ovarian cancer has the potential to dramatically reduce mortality. Recently, the use of mass spectrometry to develop profiles of patient serum proteins, combined with advanced data mining algorithms has been reported as a promising method to achieve this goal. In this report, we analyze the Ovarian Dataset 8-7-02 downloaded from the Clinical Proteomics Program Databank website, using nonparametric statistics and stepwise discriminant analysis to develop rules to diagnose patients, as well as to understand general patterns in the data that may guide future research. Results: The mass spectrometry serum profiles derived from cancer and controls exhibited numerous statistical differences. For example, use of the Wilcoxon test in comparing the intensity at each of the 15,154 mass to charge (M/Z) values between the cancer and controls, resulted in the detection of 3,591 M/Z values whose intensities differed by a p-value of 10 super(-6 )or less. The region containing the M/Z values of greatest statistical difference between cancer and controls occurred at M/Z values less than 500. For example the M/Z values of 2.7921478 and 245.53704 could be used to significantly separate the cancer from control groups. Three other sets of M/Z values were developed using a training set that could distinguish between cancer and control subjects in a test set with 100% sensitivity and specificity. Conclusions: The ability to discriminate between cancer and control subjects based on the M/Z values of 2.7921478 and 245.53704 reveals the existence of a significant non-biologic experimental bias between these two groups. This bias may invalidate attempts to use this dataset to find patterns of reproducible diagnostic value. To minimize false discovery, results using mass spectrometry and data mining algorithms should be carefully reviewed and benchmarked with routine statistical methods. JF - BMC Bioinformatics AU - Sorace, James M AU - Zhan, Min AD - Department of Pathology and Laboratory Services, Veterans Administration Maryland Health Care System, Baltimore, 21201, USA, jmsorace@ix.netcom.com Y1 - 2003 PY - 2003 DA - 2003 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 4 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Ovarian cancer KW - Data processing KW - Statistics KW - Algorithms KW - Bioinformatics KW - proteomics KW - Mass spectroscopy KW - Serum proteins KW - W4 140:Bioinformatics & Computers in Health & Medicine KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17532324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=A+data+review+and+re-assessment+of+ovarian+cancer+serum+proteomic+profiling&rft.au=Sorace%2C+James+M%3BZhan%2C+Min&rft.aulast=Sorace&rft.aufirst=James&rft.date=2003-01-01&rft.volume=4&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-4-24 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Statistics; Mass spectroscopy; Data processing; Algorithms; Ovarian cancer; proteomics; Bioinformatics; Serum proteins DO - http://dx.doi.org/10.1186/1471-2105-4-24 ER - TY - JOUR T1 - The effect of cigarette smoking on musculoskeletal-related disability AN - 17501420; 6384535 AB - This study describes cigarette smoking's effect on development of physical disability following initial musculoskeletal-related hospitalization. We followed 15,140 US Army personnel hospitalized for common musculoskeletal disorders between 1989-1996 for up to 8 years (1997) to assess risk for long- term physical disability. Trends between increased smoking level and long-term disability were identified for persons with knee injuries, rotator cuff injuries, and intervertebral disc displacement. In proportional hazards models, disability was significantly associated with heavy smoking among all subjects (relative hazard (RH) = 1.21). Both heavy smokers (RH = 1.49) and light to moderate smokers (RH = 1.44) were at greater risk for disability following meniscal injuries. Excess fraction due to smoking among subjects with meniscal injuries who currently smoke was 38%. Findings suggest an association between smoking and development of disability following meniscal injury. Given the high excess fraction of disability associated with smoking, other studies are needed to confirm this association. Published 2003 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Lincoln, Andrew E AU - Smith, Gordon S AU - Amoroso, Paul J AU - Bell, Nicole S AD - War-Related Illness and Injury Study Center, Veterans Affairs Medical Center, Washington DC, Andrew.Lincoln@med.va.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 337 EP - 349 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 43 IS - 4 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts; Risk Abstracts; Toxicology Abstracts KW - Risk assessment KW - Injuries KW - Cigarette smoke KW - Models KW - Smoking KW - Personnel KW - Disabilities KW - Cigarette smoking KW - Knee KW - Intervertebral discs KW - Light effects KW - Musculoskeletal system KW - Occupational health KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17501420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=The+effect+of+cigarette+smoking+on+musculoskeletal-related+disability&rft.au=Lincoln%2C+Andrew+E%3BSmith%2C+Gordon+S%3BAmoroso%2C+Paul+J%3BBell%2C+Nicole+S&rft.aulast=Lincoln&rft.aufirst=Andrew&rft.date=2003-01-01&rft.volume=43&rft.issue=4&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cigarette smoking; Occupational health; Musculoskeletal system; Disabilities; Smoking; Injuries; Intervertebral discs; Models; Personnel; Risk assessment; Light effects; Knee; Cigarette smoke ER - TY - JOUR T1 - Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor. AN - 72754637; 12475240 AB - Drug intervention that prevents reabsorption of circulating bile acids by the apical (ileal) sodium/bile acid cotransporter (ASBT) may be a promising new therapy for lowering of plasma cholesterol. 2164U90 is a benzothiazepine-based competitive inhibitor of bile acid transport with K(i) values of approximately 10 and 0.068 microM for the homologous human and mouse apical transporters, respectively. Hybrid human-mouse and mouse-human transporters were engineered to identify regions involved in this 150-fold difference in the inhibition constant for 2164U90. A mouse-human chimera with only the most C-terminal hydrophobic domain and the C-terminus of the transporter originating from the human variant was found to have a sensitivity to 2164U90 inhibition similar to that of the human transporter. Conversely, a human-mouse hybrid transporter encompassing the same C-terminal region from the mouse sequence but now inserted into the human sequence demonstrated the greater inhibition seen with the mouse wild type ASBT. Amino acid substitutions, individually or in combinations, of six candidate nonconserved residues between mouse and human transporters in this C-terminal domain showed replacements of Thr294 by Ser and Val295 by Ile to be responsible for the difference in the sensitivity toward 2164U90 seen between the species. The hamster apical SBAT encompassing Ser/Ile in these positions shared the lower sensitivity to 2164U90, as seen with the human ASBT, even though it is identical to the mouse SBAT in the remaining four positions of this region. In addition, the rat ASBT which is identical to the mouse ASBT in this domain also had the high sensitivity to 2164U90 inhibition found for the mouse ASBT. Methanethiosulfonates (MTS) are known to inactivate the sodium/bile acid transporters through alkylation of a cysteine in the most C-terminal hydrophobic domain (1). Inactivation of the human ASBT due to MTS modification of cysteine 270 was shown to be largely abolished when the transporter was preincubated with 2164U90, suggesting that the binding of this benzothiazepine is in the vicinity of position 270. Thus, the domain containing the two most C-terminal putative transmembrane regions of the SBATs, H8-H9, previously shown to constitute part of the binding pocket for bile acids, interacts also with the bile acid transport competitive inhibitor, 2164U90. JF - Biochemistry AU - Hallén, S AU - Björquist, A AU - Ostlund-Lindqvist, A M AU - Sachs, G AD - UCLA and the Wadsworth Veterans Administration Hospital, Los Angeles, California 90073, USA. Y1 - 2002/12/17/ PY - 2002 DA - 2002 Dec 17 SP - 14916 EP - 14924 VL - 41 IS - 50 SN - 0006-2960, 0006-2960 KW - 2164U90 KW - 0 KW - Bile Acids and Salts KW - Carrier Proteins KW - Membrane Glycoproteins KW - Mesylates KW - Organic Anion Transporters, Sodium-Dependent KW - Peptide Fragments KW - Recombinant Fusion Proteins KW - Symporters KW - Thiazepines KW - bile acid binding proteins KW - sodium-bile acid cotransporter KW - 145420-23-1 KW - (2-(trimethylammonium)ethyl)methanethiosulfonate KW - 155450-08-1 KW - Threonine KW - 2ZD004190S KW - Serine KW - 452VLY9402 KW - Taurocholic Acid KW - 5E090O0G3Z KW - Hydroxysteroid Dehydrogenases KW - EC 1.1.- KW - AKR1C2 protein, human KW - EC 1.1.1.- KW - Valine KW - HG18B9YRS7 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Animals KW - Taurocholic Acid -- metabolism KW - Threonine -- genetics KW - Humans KW - Mesylates -- metabolism KW - Valine -- genetics KW - Mesylates -- chemistry KW - Binding, Competitive -- genetics KW - Mutagenesis, Site-Directed KW - Rats KW - Recombinant Fusion Proteins -- metabolism KW - Cysteine -- chemistry KW - Sequence Alignment KW - Molecular Sequence Data KW - CHO Cells KW - Peptide Fragments -- metabolism KW - Recombinant Fusion Proteins -- antagonists & inhibitors KW - Cysteine -- metabolism KW - Peptide Fragments -- genetics KW - Amino Acid Sequence KW - Mice KW - Peptide Fragments -- antagonists & inhibitors KW - Serine -- genetics KW - Biological Transport, Active -- genetics KW - Kinetics KW - Cell Line KW - Cricetinae KW - Carrier Proteins -- metabolism KW - Carrier Proteins -- antagonists & inhibitors KW - Carrier Proteins -- chemistry KW - Carrier Proteins -- genetics KW - Ileum -- metabolism KW - Bile Acids and Salts -- metabolism KW - Ileum -- chemistry KW - Thiazepines -- chemistry KW - Bile Acids and Salts -- antagonists & inhibitors KW - Thiazepines -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72754637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Identification+of+a+region+of+the+ileal-type+sodium%2Fbile+acid+cotransporter+interacting+with+a+competitive+bile+acid+transport+inhibitor.&rft.au=Hall%C3%A9n%2C+S%3BBj%C3%B6rquist%2C+A%3BOstlund-Lindqvist%2C+A+M%3BSachs%2C+G&rft.aulast=Hall%C3%A9n&rft.aufirst=S&rft.date=2002-12-17&rft.volume=41&rft.issue=50&rft.spage=14916&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-30 N1 - Date created - 2002-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Managing infections in the elderly: The challenge of long-term care facilities AN - 18668472; 5569041 AB - Infections in the elderly that reside in long-term care facilities (LTCFs) are posing a significant challenge to clinicians. The most common infections encountered in LTCFs are pneumonia, urinary tract infections (UTIs), and skin and soft tissue infections. UTIs are the most common infections, while pneumonia is associated with the most mortality. It is often exceptionally difficult to diagnose an infectious-disease syndrome and make an accurate bacteriological diagnosis. Culture data may not always capture the true pathogenic organism(s), and clinical clues are often subtle. Antibiotic resistance is also an extremely important consideration in the decisions for empiric therapy. The concern for the presence of antimicrobial resistance must be balanced by the appropriate use of broad-spectrum agents only when they are indicated. Carefully designed clinical studies are needed. JF - Clinical Microbiology Newsletter AU - Bonomo, R A AU - Salata, R A AD - Infectious Diseases Section, Geriatrics and Long Term Care, Louis Stokes Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA, Robert.Bonomo@med.va.gov Y1 - 2002/12/15/ PY - 2002 DA - 2002 Dec 15 SP - 183 EP - 186 VL - 24 IS - 24 SN - 0196-4399, 0196-4399 KW - Long-term care facilities KW - antibiotic resistance KW - disease control KW - elderly KW - infectious diseases KW - long-term care KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - J 02855:Human Bacteriology: Others KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18668472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+Newsletter&rft.atitle=Managing+infections+in+the+elderly%3A+The+challenge+of+long-term+care+facilities&rft.au=Bonomo%2C+R+A%3BSalata%2C+R+A&rft.aulast=Bonomo&rft.aufirst=R&rft.date=2002-12-15&rft.volume=24&rft.issue=24&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+Newsletter&rft.issn=01964399&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Unexpected Advanced Generation Cephalosporinase Activity of the M69F Variant of SHV [beta]-Lactamase AN - 18627273; 5523609 AB - Infections with bacteria that contain hydrolytic [beta]-lactamase enzymes are becoming a serious problem in the United States. Mutations at Met-69, an amino acid proximal to the active site Ser-70 in the TEM-1 and SHV-1 [beta]-lactamases, have emerged as a puzzling cause of bacterial resistance to inhibitors of [beta]-lactamases. Site-saturation mutagenesis of the 69 position in SHV [beta]-lactamase was performed to determine how mutations of this non-catalytic residue play a role in increasing 50% inhibitory concentrations (IC sub(50) concentrations) for clinically important [beta]-lactamase enzyme inhibitors. Two distinct phenotypes are evident in the variant [beta]-lactamases studied: significantly increased minimum inhibitory concentrations ( mu g/ml) and IC sub(50) concentrations to clavulanic acid for the Met69Ile, Leu, and Val substitutions, and unanticipated increased minimum inhibitory concentrations and hydrolytic activity toward ceftazidime, an advanced generation cephalosporin antibiotic, for the Met69Lys, Tyr- and Phe-substituted enzymes. Molecular modeling studies emphasize the conserved structure of these substitutions despite great variation in substrate specificity. This study demonstrates the key role of Met-69 in defining substrate specificity of SHV [beta]-lactamases and alerts us to new phenotypes that may emerge clinically. JF - Journal of Biological Chemistry AU - Helfand AU - Hujer, AM AU - Soennichsen, F D AU - Bonomo, R A AD - Infectious Disease Division, University Hospitals of Cleveland, Cleveland, Ohio, robert.bonomo@med.va.gov. Y1 - 2002/12/06/ PY - 2002 DA - 2002 Dec 06 SP - 47719 EP - 47723 VL - 277 IS - 49 SN - 0021-9258, 0021-9258 KW - cephalosporinase KW - molecular modeling KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - J 02728:Enzymes KW - N 14681:Mutagenesis techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18627273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Unexpected+Advanced+Generation+Cephalosporinase+Activity+of+the+M69F+Variant+of+SHV+%5Bbeta%5D-Lactamase&rft.au=Helfand%3BHujer%2C+AM%3BSoennichsen%2C+F+D%3BBonomo%2C+R+A&rft.aulast=Helfand&rft.aufirst=&rft.date=2002-12-06&rft.volume=277&rft.issue=49&rft.spage=47719&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Molecular analysis of surgical margins in head and neck squamous cell carcinoma patients. AN - 85365171; pmid-12461330 AB - Molecular analysis of surgical margins is playing an increasingly important role in establishing surgical margins. Most markers lack the sensitivity and ease of applicability for effective clinical use. To date, the proto-oncogene eIF4E (4E) is elevated in 100% of head and neck squamous cell carcinoma tumors and is of prognostic value in predicting recurrence. In a retrospective study, 4E overexpression in the margins appeared to be a more sensitive predictor of recurrence when compared with p53. The goal was to confirm this finding in a prospective study and also to compare the expression of matrix metalloproteinase-9 (MMP-9) to 4E expression in tumors and margins. Other objectives were to determine which of these markers have prognostic significance in predicting recurrence and elucidate whether there is any additional benefit to analysis of surgical margins with a combination of the three molecular markers.A prospective study was performed on all patients who consecutively underwent primary surgical resection between 1998 and 1999 for head and neck squamous cell carcinoma. Patient and tumor characteristics were reviewed, and time to recurrence was noted.Paraffin-embedded sections of tumors and all histologically tumor-free margins were analyzed for the presence or absence of 4E, p53, and MMP-9 with immunohistochemical analysis. Patients were followed according to the institution's head and neck cancer protocol, and time to recurrence was noted.Ninety-eight percent of tumors overexpressed 4E, 65% overexpressed p53, and 92% overexpressed MMP-9. Of the 52 patients with tumor-free margins, 52%, 46%, and 54% had positive margins for 4E, p53, and MMP-9, respectively. Although no significant correlation between 4E and p53 expression was seen in the margins (P =.16), a significant correlation between 4E and MMP-9 expression was noted (P =.0002). However, when expression of 4E and p53 in the margins of only the patients who overexpressed p53 in the tumors was compared (n = 34), there was a significant correlation (P =.04). There was also a significant difference in the disease-free interval between patients with 4E-positive and 4E-negative margins (P =.003). This difference in time to recurrence was not significant for the p53-positive versus the p53-negative group (P =.18) but approached significance when MMP-9 was used as a marker (P =.07). Although the univariate analysis showed that stage, nodal disease, grade, and 4E expression in the margins were significantly associated with disease-free interval, in the Cox multiple regression analysis, only 4E expression in the margin was significantly associated with disease-free interval (P =.01).The era for molecular analysis of surgical margins is here. Although a significant correlation was seen between 4E and MMP-9, overexpression of 4E appears to be a significant predictor of recurrence when compared with the well-studied tumor suppressor gene p53 and a relatively novel marker, MMP-9. JF - The Laryngoscope AU - Nathan, Cherie-Ann O AU - Amirghahri, Nazanin AU - Rice, Cliff AU - Abreo, Fleurette W AU - Shi, Runhua AU - Stucker, Fred J AD - Department of Otolaryngology-Head and Neck Surgery, the Feist-Weiller Cancer Center, Louisiana State University Health Science Center and Veterans Administration Shreveport, 71130, USA.cnatha@lsuhsc.edu Y1 - 2002/12// PY - 2002 DA - Dec 2002 SP - 2129 EP - 2140 VL - 112 IS - 12 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - *Carcinoma, Squamous Cell: genetics KW - Carcinoma, Squamous Cell: surgery KW - *Eukaryotic Initiation Factor-4E: genetics KW - Eukaryotic Initiation Factor-4E: metabolism KW - Female KW - *Head and Neck Neoplasms: genetics KW - Head and Neck Neoplasms: surgery KW - Humans KW - Immunohistochemistry KW - Male KW - *Matrix Metalloproteinase 9: genetics KW - Matrix Metalloproteinase 9: metabolism KW - Middle Aged KW - Neoplasm Recurrence, Local: genetics KW - Proportional Hazards Models KW - Prospective Studies KW - Time Factors KW - Tumor Markers, Biological: genetics KW - Tumor Markers, Biological: metabolism KW - Tumor Suppressor Protein p53: genetics KW - Tumor Suppressor Protein p53: metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85365171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Molecular+analysis+of+surgical+margins+in+head+and+neck+squamous+cell+carcinoma+patients.&rft.au=Nathan%2C+Cherie-Ann+O%3BAmirghahri%2C+Nazanin%3BRice%2C+Cliff%3BAbreo%2C+Fleurette+W%3BShi%2C+Runhua%3BStucker%2C+Fred+J&rft.aulast=Nathan&rft.aufirst=Cherie-Ann&rft.date=2002-12-01&rft.volume=112&rft.issue=12&rft.spage=2129&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Zoonotic infections in travelers to the tropics. AN - 72867861; 12687899 AB - Infections that normally occur in animal hosts, zoonoses are transmitted occasionally between animals and humans. Zoonoses occur worldwide, and the traveler may engage in activities increasing the risk of acquiring these otherwise rare infections. This article reviews selected zoonoses in the context of travel to the tropics. JF - Primary care AU - Sellman, Jonathan AU - Bender, Jeff AD - Infectious Disease Section (111F), Minneapolis Veterans Administration Medical Center, One Veterans Drive Minneapolis, MN 55417, USA. jonathansellman@netscape.net Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 907 EP - 29, vii VL - 29 IS - 4 SN - 0095-4543, 0095-4543 KW - Index Medicus KW - Animals KW - Bacterial Infections -- prevention & control KW - Humans KW - Parasitic Diseases -- prevention & control KW - Disease Reservoirs KW - Bites and Stings KW - Virus Diseases -- prevention & control KW - Tropical Climate KW - Travel KW - Zoonoses KW - Primary Health Care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72867861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Primary+care&rft.atitle=Zoonotic+infections+in+travelers+to+the+tropics.&rft.au=Sellman%2C+Jonathan%3BBender%2C+Jeff&rft.aulast=Sellman&rft.aufirst=Jonathan&rft.date=2002-12-01&rft.volume=29&rft.issue=4&rft.spage=907&rft.isbn=&rft.btitle=&rft.title=Primary+care&rft.issn=00954543&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-24 N1 - Date created - 2003-04-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Three- to four-year follow-up to an open trial of nefazodone for combat-related posttraumatic stress disorder. AN - 72860460; 12630657 AB - Multiyear (37-51 months) follow-up data was obtained on patients who had participated in an open label trial of nefazodone that originally showed nefazodone may be useful for symptom management in posttraumatic stress disorder (PTSD) patients. Ten patients with combat-related DSM-IV posttraumatic stress disorder (PTSD) entered an open-label 12-week trial of nefazodone, beginning with 100 mg/day and increasing as necessary to achieve a maximal response or until reaching a maximum dosage of 600 mg/day. All 10 patients were followed for over 3-4 years and used nefazodone with dosages of 400-600 mg a day. The entire dosagewas shifted to bedtime to facilitate sleep in 7 patients. Data on PTSD symptoms, depression, sleep, and anger were examined. Nefazodone was well tolerated and no significant changes in sexual function were reported. All participants reported compliance with the prescribed nefazodone over 3-4 years. Nine patients reported that it remained effective, and expressed a desire to remain on the medication. On the basis of clinician global impression ratings (compared to baseline), 10 patients were rated as much improved at 12 weeks. Seven of the 10 patients continued to be much improved, 2 were minimally improved, and 1 was rated as worse (compared to baseline assessment) on 3-4-year follow-up. At 3-4-year follow-up, improvements in PTSD symptoms, sleep, and anger were maintained. These improvements were statistically significant with moderate-to-large effect sizes. These data suggest that clinical improvement in PTSD patients administered nefazodone may be maintained with continued treatment. The medication was tolerated well in long-term treatment, compliance was high, and improvement was maintained over several years. Length of treatment, appropriate dose, long-term efficacy, and compliance are all clinically significant issues with little guiding data available. Controlled studies are needed to (a) further investigate the long-term efficacy of nefazodone in the treatment of PTSD; (b) provide information for length of treatment guidelines; and (c) document if discontinuation is possible and efficacious. JF - Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists AU - Hertzberg, Michael A AU - Feldman, Michelle E AU - Beckham, Jean C AU - Moore, Scott D AU - Davidson, Jonathan R T AD - Duke University Medical Center, Department of Psychiatry, Durham, North Carolina, USA. michael.hertzberg@med.va.gov Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 215 EP - 221 VL - 14 IS - 4 SN - 1040-1237, 1040-1237 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Triazoles KW - nefazodone KW - 59H4FCV1TF KW - Index Medicus KW - Depressive Disorder, Major -- diagnosis KW - Humans KW - Clinical Trials as Topic KW - Anger -- drug effects KW - Depressive Disorder, Major -- drug therapy KW - Sleep -- drug effects KW - Patient Compliance KW - Depressive Disorder, Major -- psychology KW - Adult KW - Treatment Outcome KW - Chronic Disease KW - Follow-Up Studies KW - Middle Aged KW - Male KW - Middle East KW - Combat Disorders -- psychology KW - Antidepressive Agents, Second-Generation -- adverse effects KW - Antidepressive Agents, Second-Generation -- therapeutic use KW - Combat Disorders -- drug therapy KW - Veterans -- psychology KW - Combat Disorders -- diagnosis KW - Triazoles -- therapeutic use KW - Triazoles -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72860460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+clinical+psychiatry+%3A+official+journal+of+the+American+Academy+of+Clinical+Psychiatrists&rft.atitle=Three-+to+four-year+follow-up+to+an+open+trial+of+nefazodone+for+combat-related+posttraumatic+stress+disorder.&rft.au=Hertzberg%2C+Michael+A%3BFeldman%2C+Michelle+E%3BBeckham%2C+Jean+C%3BMoore%2C+Scott+D%3BDavidson%2C+Jonathan+R+T&rft.aulast=Hertzberg&rft.aufirst=Michael&rft.date=2002-12-01&rft.volume=14&rft.issue=4&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Annals+of+clinical+psychiatry+%3A+official+journal+of+the+American+Academy+of+Clinical+Psychiatrists&rft.issn=10401237&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-07-01 N1 - Date created - 2003-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intravascular adenoviral agents in cancer patients: lessons from clinical trials. AN - 72819640; 12522437 AB - A large number of adenoviral agents are being developed for the treatment of cancer. However, the treatment-related death of a patient with ornithine transcarbamylase deficiency following adenovirus administration by hepatic artery has led to serious concerns regarding the safety of intravascular adenovirus. Both replication-incompetent (rAd.p53, e.g., SCH58500) and replication-selective (dl1520, aka Onyx-015; CG7870) oncolytic adenoviruses, by intravascular administration, are in clinical trials. We review Phases I and I/II results from these clinical trials. dl1520 and rAd.p53 were well-tolerated following hepatic artery infusion at doses of up to 2x10(12) and 2.5x10(13) particles, respectively. At a dose of 7.5x10(13) particles, rAd.p53 was associated with dose-limiting cardiac output suppression; dl1520 dose escalation did not proceed higher than 2x10(12). Intravenous (i.v.) infusions of dl1520 and CG7870 have been well tolerated by i.v. infusion at doses of 2x10(13) and 6x10(12), respectively, without identification of a maximally tolerated dose to date. Mild/moderate transaminitis was demonstrated in some patients on both the hepatic arterial and i.v. trials at doses >or=10(12) particles. Interleukin (IL)-6 and IL-10 were induced in a dose-dependent manner in most patients, but significant interpatient and intrapatient (on repeat doses) variabilities were demonstrated. Evidence of p53 gene expression (Ad.p53) or viral replication (dl1520) was demonstrated in the majority of patients receiving >or=10(12) particles. Over 100 cancer patients have been treated with intravascular adenovirus constructs to date with an acceptable toxicity profile; further clinical trial testing appears appropriate in cancer patients. JF - Cancer gene therapy AU - Reid, Tony AU - Warren, Robert AU - Kirn, David AD - Stanford University, Palo Alto Veterans Administration Hospital, Palo Alto, California, USA. Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 979 EP - 986 VL - 9 IS - 12 SN - 0929-1903, 0929-1903 KW - Antineoplastic Agents KW - 0 KW - ONYX015 KW - Viral Vaccines KW - Index Medicus KW - Virus Replication KW - Dose-Response Relationship, Drug KW - Humans KW - Transgenes KW - Gene Expression KW - Genetic Therapy -- methods KW - Maximum Tolerated Dose KW - Drug Administration Routes KW - Clinical Trials as Topic -- statistics & numerical data KW - Neoplasms -- virology KW - Viral Vaccines -- adverse effects KW - Antineoplastic Agents -- pharmacokinetics KW - Viral Vaccines -- pharmacokinetics KW - Neoplasms -- therapy KW - Adenoviridae -- genetics KW - Antineoplastic Agents -- adverse effects KW - Genetic Vectors -- therapeutic use KW - Genetic Vectors -- adverse effects KW - Genetic Vectors -- pharmacokinetics KW - Antineoplastic Agents -- therapeutic use KW - Viral Vaccines -- therapeutic use KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72819640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+gene+therapy&rft.atitle=Intravascular+adenoviral+agents+in+cancer+patients%3A+lessons+from+clinical+trials.&rft.au=Reid%2C+Tony%3BWarren%2C+Robert%3BKirn%2C+David&rft.aulast=Reid&rft.aufirst=Tony&rft.date=2002-12-01&rft.volume=9&rft.issue=12&rft.spage=979&rft.isbn=&rft.btitle=&rft.title=Cancer+gene+therapy&rft.issn=09291903&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-06-13 N1 - Date created - 2003-01-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vaccines for Category A bioterrorism diseases. AN - 72814933; 12517267 AB - Vaccination programmes are very successful as a preventive strategy against many infectious diseases which have had a major impact on human morbidity and mortality. One of these diseases, smallpox, has been eliminated as a natural infection. The recent concern about biological attacks has turned attention to the use of an immunisation programme to prevent infection with what are considered the most significant potentially harmful biowarfare pathogens. This review puts into perspective the available information on current immunisation and newer vaccine options for anthrax, smallpox, tularaemia, plague and botulism. JF - Expert opinion on biological therapy AU - Lutwick, Larry I AU - Nierengarten, Mary Beth AD - Division of Infectious Diseases (IIIE), Veterans Affairs New York Harbor Healthcare System, 800 Poly Place, Brooklyn, New York 11209, USA. larry.lutwick@med.va.gov Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 883 EP - 893 VL - 2 IS - 8 SN - 1471-2598, 1471-2598 KW - Vaccines KW - 0 KW - Index Medicus KW - Animals KW - Tularemia -- immunology KW - Botulism -- prevention & control KW - Plague -- prevention & control KW - Humans KW - Smallpox -- immunology KW - Botulism -- immunology KW - Anthrax -- prevention & control KW - Smallpox -- prevention & control KW - Anthrax -- immunology KW - Tularemia -- prevention & control KW - Mass Vaccination KW - Plague -- immunology KW - Vaccines -- therapeutic use KW - Bioterrorism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72814933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+biological+therapy&rft.atitle=Vaccines+for+Category+A+bioterrorism+diseases.&rft.au=Lutwick%2C+Larry+I%3BNierengarten%2C+Mary+Beth&rft.aulast=Lutwick&rft.aufirst=Larry&rft.date=2002-12-01&rft.volume=2&rft.issue=8&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+biological+therapy&rft.issn=14712598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-12-19 N1 - Date created - 2003-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An investigation of predictors of nicotine abstinence in a smoking cessation treatment study of smokers with a past history of alcohol dependence. AN - 72806203; 12503909 AB - This study investigated predictors for smoking abstinence at 12-week follow-up among 85 smokers with a past history of alcohol dependence enrolled in a smoking cessation trial. Length of alcohol abstinence at time of enrollment and longest previous period of smoking abstinence were significantly associated with smoking status at follow-up. Multiple logistic regression with these variables entered as predictors suggested that longest previous period of smoking abstinence partially mediated the relationship between length of alcohol abstinence at enrollment and smoking status at follow-up. Additional research is warranted to identify predictors of nicotine abstinence and smoking relapse in this population and to understand the factors that mediate the relationship between length of alcohol abstinence at enrollment and smoking outcome. JF - Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors AU - Kalman, David AU - Tirch, Dennis AU - Penk, Walter AU - Denison, Helen AD - Department of Psychiatry, School of Medicine, Boston University, Massachusetts, USA. david.kalman@med.va.gov Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 346 EP - 349 VL - 16 IS - 4 SN - 0893-164X, 0893-164X KW - Index Medicus KW - Humans KW - Adult KW - Treatment Outcome KW - Prognosis KW - Male KW - Female KW - Smoking Cessation -- psychology KW - Tobacco Use Disorder -- rehabilitation KW - Alcoholism -- therapy KW - Tobacco Use Disorder -- diagnosis KW - Tobacco Use Disorder -- complications KW - Alcoholism -- complications KW - Smoking Cessation -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72806203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+of+addictive+behaviors+%3A+journal+of+the+Society+of+Psychologists+in+Addictive+Behaviors&rft.atitle=An+investigation+of+predictors+of+nicotine+abstinence+in+a+smoking+cessation+treatment+study+of+smokers+with+a+past+history+of+alcohol+dependence.&rft.au=Kalman%2C+David%3BTirch%2C+Dennis%3BPenk%2C+Walter%3BDenison%2C+Helen&rft.aulast=Kalman&rft.aufirst=David&rft.date=2002-12-01&rft.volume=16&rft.issue=4&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=Psychology+of+addictive+behaviors+%3A+journal+of+the+Society+of+Psychologists+in+Addictive+Behaviors&rft.issn=0893164X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-02-12 N1 - Date created - 2002-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Timing of alcohol and smoking cessation study. AN - 72795824; 12500130 JF - Alcoholism, clinical and experimental research AU - Joseph, Anne M AU - Willenbring, Mark L AU - Nelson, Dave AU - Nugent, Sean M AD - Center for Chronic Disease Outcomes Research, Minneapolis, Minnesota 55417, USA. Anne.M.Joseph@med.va.gov Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 1945 EP - 1946 VL - 26 IS - 12 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Humans KW - Temperance -- psychology KW - Follow-Up Studies KW - Time Factors KW - Smoking Cessation -- psychology KW - Alcoholism -- therapy KW - Smoking Cessation -- methods KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72795824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Timing+of+alcohol+and+smoking+cessation+study.&rft.au=Joseph%2C+Anne+M%3BWillenbring%2C+Mark+L%3BNelson%2C+Dave%3BNugent%2C+Sean+M&rft.aulast=Joseph&rft.aufirst=Anne&rft.date=2002-12-01&rft.volume=26&rft.issue=12&rft.spage=1945&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-06-05 N1 - Date created - 2002-12-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction in patients with diabetes mellitus. AN - 72784083; 12494279 AB - Sildenafil, a phosphodiesterase 5 (PDE5) inhibitor, has become a first-line therapy for diabetic patients with erectile dysfunction (ED). The efficacy in this subgroup, based on the Global Efficacy Question, is 56% vs 84% in a selected group of non-diabetic men with ED. Two novel PDE5 inhibitors, tadalafil (Lilly ICOS) and vardenafil (Bayer), have recently completed efficacy and safety clinical trials in 'general' and diabetic study populations and are now candidates for US FDA approval. A summary analysis of the phase three clinical trials of sildenafil, tadalafil and vardenafil in both study populations is presented to provide a foundation on which the evaluation of the role of the individual PDE5 inhibitors for the treatment of patients with ED and DM can be built. JF - International journal of impotence research AU - Vickers, M A AU - Satyanarayana, R AD - Department of Surgery, Togus VA Medical Center, Togus, Maine 04330, USA. Martyn.Vickers@med.va.gov Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 466 EP - 471 VL - 14 IS - 6 SN - 0955-9930, 0955-9930 KW - Carbolines KW - 0 KW - Imidazoles KW - Phosphodiesterase Inhibitors KW - Piperazines KW - Purines KW - Sulfones KW - Triazines KW - Vardenafil Dihydrochloride KW - 5O8R96XMH7 KW - Tadalafil KW - 742SXX0ICT KW - Sildenafil Citrate KW - BW9B0ZE037 KW - Phosphoric Diester Hydrolases KW - EC 3.1.4.- KW - 3',5'-Cyclic-GMP Phosphodiesterases KW - EC 3.1.4.35 KW - Cyclic Nucleotide Phosphodiesterases, Type 5 KW - PDE5A protein, human KW - Index Medicus KW - Multicenter Studies as Topic KW - Randomized Controlled Trials as Topic KW - Clinical Trials, Phase III as Topic KW - Humans KW - Male KW - Carbolines -- adverse effects KW - Piperazines -- therapeutic use KW - Erectile Dysfunction -- drug therapy KW - Imidazoles -- therapeutic use KW - Piperazines -- adverse effects KW - Phosphoric Diester Hydrolases -- drug effects KW - Phosphodiesterase Inhibitors -- therapeutic use KW - Phosphodiesterase Inhibitors -- adverse effects KW - Imidazoles -- adverse effects KW - Erectile Dysfunction -- complications KW - Diabetes Complications KW - Carbolines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72784083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+impotence+research&rft.atitle=Phosphodiesterase+type+5+inhibitors+for+the+treatment+of+erectile+dysfunction+in+patients+with+diabetes+mellitus.&rft.au=Vickers%2C+M+A%3BSatyanarayana%2C+R&rft.aulast=Vickers&rft.aufirst=M&rft.date=2002-12-01&rft.volume=14&rft.issue=6&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=International+journal+of+impotence+research&rft.issn=09559930&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-08-01 N1 - Date created - 2002-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dose-dependent effect of ethanol on extracellular dopamine in mesolimbic striatum of awake rhesus monkeys: comparison with cocaine across individuals. AN - 72756003; 12474120 AB - Dependence on both alcohol and cocaine is a widespread example of polydrug abuse/dependence. It has been hypothesized that ethanol reward is mediated via increased dopaminergic neurotransmission in mesolimbic striatum, as is the case for cocaine. However, little is known about the neurobiology of ethanol in primates, or how the effects of ethanol compare to those of cocaine across individual animals. To determine in animals with a history of cocaine exposure whether there is a dopaminergic impact of ethanol in non-human primates, and if so, whether the magnitude of that effect correlates with the dopaminergic effect of cocaine across individuals. Microdialysis studies were conducted in rhesus monkeys previously trained to self-administer cocaine. The dopaminergic impact of cocaine had been determined in those animals during cocaine self-administration sessions. Probes were placed in the ventral mesolimbic and associational central striatum. Ethanol was administered non-contingently by a slow intravenous infusion at doses of 0.5 g/kg (administered over 10 min) and 1.0 g/kg (administered over 20 min). The mean dopaminergic response to ethanol in four animals (with 2-4 trials in each animal at each dose) indicated a small but significant increase in extracellular dopamine at each dose (12% above baseline at 0.5 g/kg, 22% above baseline at 1.0 g/kg). Examining the responses across individual animals indicated substantial variability, in that two of the four animals showed no increase at either dose. Across individuals, regression analysis of cocaine-induced changes in dopamine with 1.0 g/kg ethanol-induced changes indicated a positive correlation between the drug effects, with a trend in this direction observed with the 0.5-g/kg dose of ethanol. These results provide support for the ability of ethanol to elevate extracellular dopamine in the mesolimbic striatum, though with a modest effect size and variability among individuals. Further, they suggest that some common mechanism influences the effects of ethanol and cocaine on dopaminergic output despite seemingly unrelated pharmacological mechanisms of action. JF - Psychopharmacology AU - Bradberry, Charles W AD - Department of Psychiatry, Yale University School of Medicine and Veterans Administration Connecticut Health Services, 950 Campbell Avenue, Mail Stop 116A2, West Haven, CT 06516, USA. charles.bradberry@yale.edu Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 67 EP - 76 VL - 165 IS - 1 SN - 0033-3158, 0033-3158 KW - Central Nervous System Depressants KW - 0 KW - Dopamine Uptake Inhibitors KW - Ethanol KW - 3K9958V90M KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Microdialysis KW - Regression Analysis KW - Animals KW - Analysis of Variance KW - Self Administration KW - Extracellular Space -- chemistry KW - Dose-Response Relationship, Drug KW - Macaca mulatta KW - Time Factors KW - Extracellular Space -- drug effects KW - Cocaine-Related Disorders -- metabolism KW - Male KW - Central Nervous System Depressants -- pharmacology KW - Ethanol -- pharmacology KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Dopamine -- metabolism KW - Cocaine -- pharmacology KW - Cocaine -- administration & dosage KW - Basal Ganglia -- drug effects KW - Dopamine Uptake Inhibitors -- pharmacology KW - Basal Ganglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72756003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Dose-dependent+effect+of+ethanol+on+extracellular+dopamine+in+mesolimbic+striatum+of+awake+rhesus+monkeys%3A+comparison+with+cocaine+across+individuals.&rft.au=Bradberry%2C+Charles+W&rft.aulast=Bradberry&rft.aufirst=Charles&rft.date=2002-12-01&rft.volume=165&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-20 N1 - Date created - 2002-12-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Motivational responses to natural and drug rewards in rats with neonatal ventral hippocampal lesions: an animal model of dual diagnosis schizophrenia. AN - 72737701; 12464446 AB - The high prevalence of substance use disorders in schizophrenia relative to the general population and other psychiatric diagnoses could result from developmental neuropathology in hippocampal and cortical structures that underlie schizophrenia. In this study, we tested the effects of neonatal ventral hippocampal lesions on instrumental behavior reinforced by sucrose pellets and intravenous cocaine injections. Lesioned rats acquired sucrose self-administration faster than sham-lesioned rats, but rates of extinction were not altered. Lesioned rats also responded at higher rates during acquisition of cocaine self-administration, and tended to acquire self-administration faster. Higher response rates reflected perseveration of responding during the post-injection "time-out" periods, and a greater incidence of binge-like cocaine intake, which persisted even after cocaine self-administration stabilized. In contrast to sucrose, extinction from cocaine self-administration was prolonged in lesioned rats, and reinstatement of cocaine seeking induced by cocaine priming increased compared with shams. These results suggest that neonatal ventral hippocampal lesions facilitate instrumental learning for both natural and drug rewards, and reduce inhibitory control over cocaine taking while promoting cocaine seeking and relapse after withdrawal. The findings are discussed in terms of possible developmental or direct effects of the lesions, and both positive reinforcement (substance use vulnerability as a primary disease symptom) and negative reinforcement (self-medication) theories of substance use comorbidity in schizophrenia. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Chambers, R Andrew AU - Self, David W AD - Division of Molecular Psychiatry, West Haven Veterans Administration Hospital, USA. robert.chambers@yale.edu Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 889 EP - 905 VL - 27 IS - 6 SN - 0893-133X, 0893-133X KW - Index Medicus KW - Rats KW - Animals, Newborn KW - Animals KW - Rats, Sprague-Dawley KW - Behavior, Addictive -- psychology KW - Self Administration -- psychology KW - Extinction, Psychological -- physiology KW - Extinction, Psychological -- drug effects KW - Diagnosis, Dual (Psychiatry) -- psychology KW - Behavior, Addictive -- physiopathology KW - Male KW - Female KW - Pregnancy KW - Reward KW - Motivation KW - Hippocampus -- physiology KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- physiopathology KW - Disease Models, Animal KW - Schizophrenia -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72737701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Motivational+responses+to+natural+and+drug+rewards+in+rats+with+neonatal+ventral+hippocampal+lesions%3A+an+animal+model+of+dual+diagnosis+schizophrenia.&rft.au=Chambers%2C+R+Andrew%3BSelf%2C+David+W&rft.aulast=Chambers&rft.aufirst=R&rft.date=2002-12-01&rft.volume=27&rft.issue=6&rft.spage=889&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-24 N1 - Date created - 2002-12-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prog Neurobiol. 1994 Oct;44(2):221-31 [7831478] J Neuropsychiatry Clin Neurosci. 1994 Fall;6(4):419-27 [7841813] J Neurosci. 1995 May;15(5 Pt 1):3622-39 [7751934] Synapse. 1995 Jun;20(2):125-30 [7570341] Biol Psychiatry. 1995 Aug 15;38(4):255-62 [8547448] Neuroreport. 1995 Oct 2;6(14):1845-8 [8547581] Behav Neurosci. 1996 Feb;110(1):60-73 [8652073] Psychopharmacology (Berl). 1995 Nov;122(1):35-43 [8711062] Curr Opin Neurobiol. 1996 Apr;6(2):228-36 [8725965] Synapse. 1996 Aug;23(4):292-301 [8855514] Behav Neurosci. 1996 Oct;110(5):1049-66 [8919008] Neuropsychopharmacology. 1996 Dec;15(6):587-94 [8946433] J Psychopharmacol. 1997;11(2):99-106 [9208373] Brain Res Dev Brain Res. 1997 Jul 18;101(1-2):17-25 [9263576] Hippocampus. 1997;7(4):397-402 [9287079] Psychopharmacology (Berl). 1997 Aug;132(3):303-10 [9292631] Science. 1997 Oct 3;278(5335):58-63 [9311927] Brain Res Bull. 1997;44(3):265-71 [9323441] J Clin Psychiatry. 1998;59 Suppl 3:26-30 [9541335] J Neurosci. 1998 Jul 1;18(13):5095-102 [9634575] Ann N Y Acad Sci. 1998 Jun 21;846:222-37 [9668410] Neuropharmacology. 1998 Apr-May;37(4-5):407-19 [9704982] Drug Alcohol Depend. 1998 Jun-Jul;51(1-2):13-22 [9716927] Drug Alcohol Depend. 1998 Jun-Jul;51(1-2):141-53 [9716936] Ann Med. 1998 Aug;30(4):379-89 [9783837] Hippocampus. 1998;8(6):608-19 [9882018] Biol Psychiatry. 1999 Feb 15;45(4):395-402 [10071707] Schizophr Res. 1999 Mar 1;35 Suppl:S93-100 [10190230] Nat Neurosci. 1998 Aug;1(4):318-23 [10195166] Eur J Neurosci. 1999 May;11(5):1598-604 [10215912] J Neural Transm (Vienna). 1999;106(2):183-96 [10226938] Neuropsychopharmacology. 1999 Jun;20(6):525-32 [10327422] Ann N Y Acad Sci. 1999 Jun 29;877:157-75 [10415649] Psychopharmacology (Berl). 1999 Jun;144(4):333-8 [10435405] Neuroreport. 1999 Aug 2;10(11):2307-11 [10439454] Psychopharmacology (Berl). 1999 Jul;145(1):61-6 [10445373] Behav Brain Res. 1999 Mar;99(2):133-41 [10512580] Neuroscience. 1999;94(4):1019-27 [10625044] Behav Brain Res. 2000 Apr;109(1):137-40 [10699665] Neuroscience. 2000;96(3):523-36 [10717433] J Neurosci. 2000 Apr 1;20(7):2711-8 [10729352] Neuropsychopharmacology. 2000 Jun;22(6):626-41 [10788762] Prog Brain Res. 2000;126:193-215 [11105648] Neuropsychopharmacology. 2001 Feb;24(2):97-129 [11120394] Behav Brain Res. 2001 Jan 29;118(2):123-41 [11164510] Neuropsychopharmacology. 2001 Jul;25(1):1-27 [11377916] J Neurosci. 2001 Jul 1;21(13):4915-22 [11425919] J Neurosci. 2001 Aug 1;21(15):5773-80 [11466449] Behav Neurosci. 2001 Aug;115(4):880-94 [11508727] Biol Psychiatry. 2001 Jul 15;50(2):71-83 [11526998] Med Aspects Hum Sex. 1976 Apr;10(4):32, 35, 39, passim [957810] Psychol Med. 1977 May;7(2):213-21 [560024] Neuroscience. 1982 Oct;7(10):2321-35 [6817161] Behav Neural Biol. 1983 Sep;39(1):7-21 [6661144] Schizophr Bull. 1990;16(1):97-110 [2185538] Brain Res. 1990 Sep 17;527(2):266-79 [1701338] Neuroscience. 1992 Jun;48(4):821-9 [1378574] Schizophr Res. 1992 Dec;8(2):119-23 [1457389] Neuropsychopharmacology. 1993 Aug;9(1):67-75 [8397725] Neuropsychopharmacology. 1994 May;10(3):199-205 [7916917] J Psychiatr Res. 1994 May-Jun;28(3):267-75 [7932286] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An analysis of cue reactivity among persons with and without schizophrenia who are addicted to cocaine. AN - 72727278; 12461224 AB - Persons with schizophrenia who are addicted to cocaine experience more psychiatric and substance abuse relapses and worse long-term outcomes than persons with only one of these conditions. This study examined whether individuals with cocaine dependence and schizophrenia experience more cue-elicited craving than those without schizophrenia. Ninety-one cocaine-dependent participants who had been abstinent from cocaine for at least 72 hours were recruited from substance abuse treatment programs in the Veterans Affairs New Jersey Health Care System. The study used a cue-exposure paradigm to stimulate cocaine craving. A self-report instrument was used to measure changes from baseline in four areas: craving intensity, happy or depressed mood, increased or decreased energy, and physical health or sickness. The participants with schizophrenia (N=35) reported significantly more cocaine craving than those without schizophrenia (N=56). When data for participants who were cue reactive were analyzed without regard to diagnosis, 97 percent of the cocaine-dependent participants with schizophrenia were cue reactive, compared with 43 percent of those without schizophrenia. Future research on cocaine dependence should focus on craving, particularly among patients with coexisting psychiatric disorders. JF - Psychiatric services (Washington, D.C.) AU - Smelson, David A AU - Losonczy, Miklos F AU - Kilker, Chris AU - Starosta, Aron AU - Kind, Jacob AU - Williams, John AU - Ziedonis, Douglas AD - Department of Veterans Affairs Mental Illness Research, Education, and Clinical Center, VISN3, Bronx, NY, USA. david.smelson@med.va.gov Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 1612 EP - 1616 VL - 53 IS - 12 SN - 1075-2730, 1075-2730 KW - Index Medicus KW - Humans KW - Depression -- psychology KW - Health Status KW - Adult KW - Middle Aged KW - Recurrence KW - Diagnostic and Statistical Manual of Mental Disorders KW - Disruptive, Impulse Control, and Conduct Disorders -- epidemiology KW - Cocaine-Related Disorders -- diagnosis KW - Cues KW - Schizophrenia -- complications KW - Cocaine-Related Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72727278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=An+analysis+of+cue+reactivity+among+persons+with+and+without+schizophrenia+who+are+addicted+to+cocaine.&rft.au=Smelson%2C+David+A%3BLosonczy%2C+Miklos+F%3BKilker%2C+Chris%3BStarosta%2C+Aron%3BKind%2C+Jacob%3BWilliams%2C+John%3BZiedonis%2C+Douglas&rft.aulast=Smelson&rft.aufirst=David&rft.date=2002-12-01&rft.volume=53&rft.issue=12&rft.spage=1612&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-21 N1 - Date created - 2002-12-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Morphology of anorexigen-associated valve disease by transthoracic and transesophageal echocardiography. AN - 72725071; 12450616 JF - The American journal of cardiology AU - Roldan, Carlos A AU - Gelgand, Erika A AU - Decker, Pamela AU - Prasad, Arti AU - Shively, Bruce K AD - Oregon Health Sciences University, Portland, Oregon, USA. carlos.roldan2@med.va.gov Y1 - 2002/12/01/ PY - 2002 DA - 2002 Dec 01 SP - 1269 EP - 1273 VL - 90 IS - 11 SN - 0002-9149, 0002-9149 KW - Appetite Depressants KW - 0 KW - Drug Combinations KW - Fenfluramine KW - 2DS058H2CF KW - Phentermine KW - C045TQL4WP KW - Dexfenfluramine KW - E35R3G56OV KW - Abridged Index Medicus KW - Index Medicus KW - Obesity -- drug therapy KW - Humans KW - Adult KW - Middle Aged KW - Body Mass Index KW - Female KW - Echocardiography, Transesophageal KW - Appetite Depressants -- adverse effects KW - Heart Valve Diseases -- diagnostic imaging KW - Fenfluramine -- therapeutic use KW - Dexfenfluramine -- adverse effects KW - Mitral Valve -- diagnostic imaging KW - Phentermine -- therapeutic use KW - Phentermine -- adverse effects KW - Fenfluramine -- adverse effects KW - Aortic Valve -- diagnostic imaging KW - Dexfenfluramine -- therapeutic use KW - Heart Valve Diseases -- etiology KW - Appetite Depressants -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72725071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Morphology+of+anorexigen-associated+valve+disease+by+transthoracic+and+transesophageal+echocardiography.&rft.au=Roldan%2C+Carlos+A%3BGelgand%2C+Erika+A%3BDecker%2C+Pamela%3BPrasad%2C+Arti%3BShively%2C+Bruce+K&rft.aulast=Roldan&rft.aufirst=Carlos&rft.date=2002-12-01&rft.volume=90&rft.issue=11&rft.spage=1269&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-30 N1 - Date created - 2002-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improving recognition of drug interactions: benefits and barriers to using automated drug alerts. AN - 72723491; 12458299 AB - Clinicians' perceptions about decision support systems may impact the effectiveness of these technologies. To explore clinicians' baseline knowledge of common drug interactions and experiences with automated drug alerts within a provider order entry system as a means to better understand the potential benefits and barriers to using this technology. Cross-sectional survey. The study population comprised 263 clinicians practicing within a Southern California Veterans Affairs health care system that used VA's Computerized Patient Record System (CPRS). Response rate was 64%. A 67-item survey (19 questions) was developed to elicit information including: (1) computer use for patient-related activities; (2) recognition of drug interactions; and (3) benefits and barriers to using automated drug alerts. Clinicians correctly categorized 44% (range 11-64%) of all drug-drug pairs, 53% of interacting combinations, and 54% of contraindicated pairs. Providers also correctly categorized 55% (range 24-87%) of 11 drug-disease pairs and 62% of interacting combinations, and 53% of contraindicated pairs. Nearly 90% of clinicians thought drug alerts would be helpful to identify interactions yet 55% of clinicians perceived that the most significant barrier to utilizing existing alerts was poor signal to noise ratio, meaning too many nonrelevant warnings. Automated drug interaction alerts have the potential to dramatically increase clinicians' recognition of selected drug interactions. However, perceived poor specificity of drug alerts may be an important obstacle to efficient utilization of information and may impede the ability of such alerts to improve patient safety. JF - Medical care AU - Glassman, Peter A AU - Simon, Barbara AU - Belperio, Pamela AU - Lanto, Andrew AD - VA HSR&D Center of Excellence for the Study of Healthcare Provider Behavior, VA Greater Los Angeles Healthcare System-West Los Angeles Campus, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA. Peter.Glassman@med.va.gov Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 1161 EP - 1171 VL - 40 IS - 12 SN - 0025-7079, 0025-7079 KW - Index Medicus KW - California KW - Regression Analysis KW - Medical Records Systems, Computerized KW - Cross-Sectional Studies KW - Computer Systems KW - Humans KW - Chi-Square Distribution KW - Surveys and Questionnaires KW - Automation KW - Hospitals, Veterans KW - Drug Interactions KW - Attitude of Health Personnel KW - Medication Errors -- prevention & control KW - Decision Support Systems, Clinical KW - Drug Therapy, Computer-Assisted UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72723491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+care&rft.atitle=Improving+recognition+of+drug+interactions%3A+benefits+and+barriers+to+using+automated+drug+alerts.&rft.au=Glassman%2C+Peter+A%3BSimon%2C+Barbara%3BBelperio%2C+Pamela%3BLanto%2C+Andrew&rft.aulast=Glassman&rft.aufirst=Peter&rft.date=2002-12-01&rft.volume=40&rft.issue=12&rft.spage=1161&rft.isbn=&rft.btitle=&rft.title=Medical+care&rft.issn=00257079&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-09 N1 - Date created - 2002-11-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quetiapine therapy for posttraumatic stress disorder. AN - 72718356; 12452747 AB - To report a case of improvement in posttraumatic stress disorder (PTSD) after adjunctive therapy with quetiapine. A 49-year-old white man witnessed a traumatic event and experienced severe PTSD. He was started on paroxetine, with increases in dosage and no significant improvement. Quetiapine was added to his regimen, with increased doses resulting in improvement of PTSD symptoms, both clinically and as measured on the Hamilton-D rating scale for depression and the clinician-administered PTSD screen. This is the first case published in the English language literature describing improvement in PTSD symptoms after treatment with quetiapine. There are several treatment options for PTSD, but some severe cases may require treatment with antipsychotic medications. Because of the lower risks of serious adverse effects, the newer atypical antipsychotics are much safer than the older antipsychotics. Although use of risperidone and olanzapine in the successful treatment of PTSD has been reported in the literature, there are no reports of quetiapine use in this clinical condition. Quetiapine appeared to improve clinical signs and symptoms of PTSD in this patient. It may be a treatment option in other severe cases of PTSD. JF - The Annals of pharmacotherapy AU - Sattar, S Pirzada AU - Ucci, Bernadette AU - Grant, Kathleen AU - Bhatia, Subhash C AU - Petty, Frederick AD - School of Medicine, Creighton University, Omaha, NE, USA. syed.sattar@med.va.gov Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 1875 EP - 1878 VL - 36 IS - 12 SN - 1060-0280, 1060-0280 KW - Antipsychotic Agents KW - 0 KW - Dibenzothiazepines KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Index Medicus KW - Humans KW - Alcoholism KW - Middle Aged KW - Male KW - Antipsychotic Agents -- therapeutic use KW - Stress Disorders, Post-Traumatic -- drug therapy KW - Dibenzothiazepines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72718356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Quetiapine+therapy+for+posttraumatic+stress+disorder.&rft.au=Sattar%2C+S+Pirzada%3BUcci%2C+Bernadette%3BGrant%2C+Kathleen%3BBhatia%2C+Subhash+C%3BPetty%2C+Frederick&rft.aulast=Sattar&rft.aufirst=S&rft.date=2002-12-01&rft.volume=36&rft.issue=12&rft.spage=1875&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-13 N1 - Date created - 2002-11-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Irbesartan substitution for valsartan or losartan in treating hypertension. AN - 72714427; 12452741 AB - To determine whether subjects whose therapy was converted from losartan or valsartan to irbesartan maintained equivalent blood pressure measurements, determine the safety and tolerability of irbesartan in the veteran population, and assess the number of subjects attaining their goal blood pressure before and after conversion. A retrospective review of medical records for subjects whose antihypertensive was converted to irbesartan was conducted. Demographic data were collected, and subjects' past medical histories were used to determine their goal blood pressure. Blood pressures were compared at baseline, 2 weeks, and 2 months after conversion to determine efficacy, and adverse effect occurrence was compared between visits to assess safety. Conversion was attempted in 79 subjects; 72 met the criteria for review. Mean baseline, 2-week, and 2-month blood pressures for all subjects were 143/74, 139/72, and 139/73 mm Hg, respectively (p values NS). The number of subjects achieving their goal blood pressure at each assessment visit was similar: 37.5% at baseline, 43.4% at 2 weeks, and 31.9% at 2 months. Thirteen of the 72 subjects discontinued irbesartan due to adverse events. Irbesartan is an appropriate substitution for valsartan or losartan. JF - The Annals of pharmacotherapy AU - Graham, Maqual R AU - Allcock, Nicole M AD - Department of Pharmacy Practice, School of Pharmacy, University of Missouri-Kansas City, USA. maqual.infranca@med.va.gov Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 1840 EP - 1844 VL - 36 IS - 12 SN - 1060-0280, 1060-0280 KW - Antihypertensive Agents KW - 0 KW - Biphenyl Compounds KW - Tetrazoles KW - Valsartan KW - 80M03YXJ7I KW - Valine KW - HG18B9YRS7 KW - irbesartan KW - J0E2756Z7N KW - Losartan KW - JMS50MPO89 KW - Index Medicus KW - Therapeutic Equivalency KW - Humans KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Blood Pressure -- drug effects KW - Male KW - Female KW - Biphenyl Compounds -- therapeutic use KW - Antihypertensive Agents -- adverse effects KW - Biphenyl Compounds -- pharmacology KW - Biphenyl Compounds -- adverse effects KW - Tetrazoles -- adverse effects KW - Antihypertensive Agents -- pharmacology KW - Tetrazoles -- administration & dosage KW - Tetrazoles -- therapeutic use KW - Hypertension -- drug therapy KW - Tetrazoles -- pharmacology KW - Biphenyl Compounds -- administration & dosage KW - Losartan -- administration & dosage KW - Antihypertensive Agents -- therapeutic use KW - Valine -- analogs & derivatives KW - Antihypertensive Agents -- administration & dosage KW - Valine -- therapeutic use KW - Losartan -- therapeutic use KW - Valine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72714427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Irbesartan+substitution+for+valsartan+or+losartan+in+treating+hypertension.&rft.au=Graham%2C+Maqual+R%3BAllcock%2C+Nicole+M&rft.aulast=Graham&rft.aufirst=Maqual&rft.date=2002-12-01&rft.volume=36&rft.issue=12&rft.spage=1840&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-13 N1 - Date created - 2002-11-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment and management of Helicobacter pylori infection. AN - 72693229; 12441037 AB - Clinical and basic mechanisms of interaction between Helicobacter pylori and its host have been the subject of numerous publications in the past year. Two additional proton pump inhibitors (PPIs), esomeprazole and rabeprazole, have shown effectiveness in H. pylori eradication when combined with amoxicillin and clarithromycin, and esomeprazole has demonstrated its effectiveness with only one daily dose. Other important recent developments worldwide include evidence-based treatment guidelines established at a European consensus meeting, improved accuracy in the urea breath test and the stool antigen test, new recommendations for second-line therapy, and a greater understanding of antimicrobial resistance in treatment failure. In addition, new studies have confirmed that H. pylori infection and use of nonsteroidal anti-inflammatory drugs or aspirin are the major causes of peptic ulcer disease and ulcer bleeding. This paper reviews the results of these studies and their implications for future research. JF - Current gastroenterology reports AU - Go, Mae F AD - Gastrointestinal Section, Veterans Administration Salt Lake City Health Care System, 500 Foothill Boulevard (111G), Salt Lake City, UT 84148, USA. mae.go@med.va.gov Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 471 EP - 477 VL - 4 IS - 6 SN - 1522-8037, 1522-8037 KW - 2-Pyridinylmethylsulfinylbenzimidazoles KW - 0 KW - Anti-Bacterial Agents KW - Anti-Inflammatory Agents, Non-Steroidal KW - Benzimidazoles KW - Enzyme Inhibitors KW - Rabeprazole KW - 32828355LL KW - Amoxicillin KW - 804826J2HU KW - Clarithromycin KW - H1250JIK0A KW - Esomeprazole KW - N3PA6559FT KW - Index Medicus KW - Anti-Bacterial Agents -- therapeutic use KW - Peptic Ulcer -- microbiology KW - Humans KW - Benzimidazoles -- therapeutic use KW - Peptic Ulcer -- chemically induced KW - Clarithromycin -- therapeutic use KW - Stomach Neoplasms -- microbiology KW - Drug Therapy, Combination KW - Amoxicillin -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Cardiovascular Diseases -- microbiology KW - Treatment Outcome KW - Esomeprazole -- therapeutic use KW - Helicobacter Infections -- diagnosis KW - Helicobacter pylori KW - Enzyme Inhibitors -- therapeutic use KW - Helicobacter Infections -- drug therapy KW - Helicobacter Infections -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72693229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+gastroenterology+reports&rft.atitle=Treatment+and+management+of+Helicobacter+pylori+infection.&rft.au=Go%2C+Mae+F&rft.aulast=Go&rft.aufirst=Mae&rft.date=2002-12-01&rft.volume=4&rft.issue=6&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Current+gastroenterology+reports&rft.issn=15228037&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-26 N1 - Date created - 2002-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nucleotide depletion increases trafficking of gentamicin to the Golgi complex in LLC-PK1 cells. AN - 72677100; 12388419 AB - Having shown rapid trafficking of aminoglycosides to the Golgi complex in cell culture, we focused on the injurious interaction that occurs when gentamicin administration is preceded by renal ischemia. Using Texas red-labeled gentamicin as a tracer, we determined that 15 min of cellular nucleotide depletion did not significantly increase subsequent uptake. However, cells previously depleted of nucleotides accumulated significantly more Texas red-labeled gentamicin within a dispersed Golgi complex. Using Ricinus communis and Lens culinaris lectins, which label specific compartments of the Golgi complex (trans-Golgi network/trans and medial/cis compartments, respectively), we determined that the medial/cis compartment dispersed after 15 min of nucleotide depletion but the trans-Golgi network/trans compartment remained unaffected. An increase in the number of cells exhibiting disrupted medial/cis-Golgi morphology after repletion in physiological media containing gentamicin was also seen. In summary, the increase in nephrotoxicity seen when ischemia precedes aminoglycoside uptake may be part of a complex mechanism initially involving increased Golgi accumulation and prolonged Golgi dispersion. The Golgi complex must then endure the effects of gentamicin accumulated in larger quantities in an aberrant physiological state. JF - American journal of physiology. Renal physiology AU - Sandoval, Ruben M AU - Bacallao, Robert L AU - Dunn, Kenneth W AU - Leiser, Jeffrey D AU - Molitoris, Bruce A AD - Department of Medicine, Division of Nephrology, Indiana University School of Medicine and Roudebush Veterans Administration Medical Center, Indianapolis, Indiana 46202, USA. Y1 - 2002/12// PY - 2002 DA - December 2002 SP - F1422 EP - F1429 VL - 283 IS - 6 SN - 1931-857X, 1931-857X KW - Anti-Bacterial Agents KW - 0 KW - Gentamicins KW - Nucleotides KW - Index Medicus KW - Swine KW - Renal Circulation KW - Animals KW - LLC-PK1 Cells KW - Tissue Distribution KW - Time Factors KW - Ischemia -- metabolism KW - Gentamicins -- pharmacokinetics KW - Kidney Tubules, Proximal -- metabolism KW - Kidney Tubules, Proximal -- ultrastructure KW - Kidney Tubules, Proximal -- pathology KW - Nucleotides -- deficiency KW - Golgi Apparatus -- metabolism KW - Anti-Bacterial Agents -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72677100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Renal+physiology&rft.atitle=Nucleotide+depletion+increases+trafficking+of+gentamicin+to+the+Golgi+complex+in+LLC-PK1+cells.&rft.au=Sandoval%2C+Ruben+M%3BBacallao%2C+Robert+L%3BDunn%2C+Kenneth+W%3BLeiser%2C+Jeffrey+D%3BMolitoris%2C+Bruce+A&rft.aulast=Sandoval&rft.aufirst=Ruben&rft.date=2002-12-01&rft.volume=283&rft.issue=6&rft.spage=F1422&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Renal+physiology&rft.issn=1931857X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-12-17 N1 - Date created - 2002-11-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mortality among US and UK veterans of the Persian Gulf War: a review AN - 19221857; 5798400 AB - Mortality data on Gulf War veterans was reviewed as a means of evaluating the long term consequences of the war. Studies were located from searches of Medline, Proceedings of the Conference on Federally Sponsored Gulf War Veterans' Illnesses Research, Proceedings of the American Public Health Association Annual Meetings, Annual Reports to Congress, and personal contacts with knowledgeable investigators. Data on study design, methods, and results were obtained from published studies of both US and UK veterans who served in the Persian Gulf. The methodology and results of studies are summarised and evaluated. Additional research recommendations based on reviewed studies are presented. It is concluded that in both US and UK studies, mortality from external causes was higher, while mortality from all illnesses was lower among Gulf War veterans in comparison to those of non-Gulf War veterans. Increased mortality from external causes is consistent with patterns of postwar mortality observed in veterans of previous wars. Further follow up of Gulf War veterans and their controls is warranted for evaluating the mortality risk from diseases with longer latency periods. JF - Occupational and Environmental Medicine AU - Kang, H K AU - Bullman, T A AU - Macfarlane, G J AU - Gray, G C AD - Environmental Epidemiology Service, Department of Veterans Affairs, 1120 20th Street, NW Suite 950, Washington, DC, 20036, USA, han.kang@mail.va.gov Y1 - 2002/12// PY - 2002 DA - Dec 2002 SP - 794 EP - 799 VL - 59 IS - 12 SN - 1351-0711, 1351-0711 KW - Health & Safety Science Abstracts KW - Mortality KW - occupational diseases KW - Arabian Sea, Persian Gulf KW - Military KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19221857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Mortality+among+US+and+UK+veterans+of+the+Persian+Gulf+War%3A+a+review&rft.au=Kang%2C+H+K%3BBullman%2C+T+A%3BMacfarlane%2C+G+J%3BGray%2C+G+C&rft.aulast=Kang&rft.aufirst=H&rft.date=2002-12-01&rft.volume=59&rft.issue=12&rft.spage=794&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Arabian Sea, Persian Gulf; Military; Occupational health; occupational diseases; Mortality ER - TY - JOUR T1 - Association of different mobile elements to generate novel integrative elements AN - 18756872; 5630356 AB - Among the more important problems in modern hospitals is the prevalence of bacterial pathogens expressing resistance to multiple antimicrobial agents. The frequency of multiresistance suggests mechanisms by which bacterial species can concentrate and efficiently exchange a variety of resistance determinants. Mechanisms by which this occurs include insertion of transposons within transposons, coalescence through the activity of insertion sequences and the employment of integrons. In some instances, more than one of these mechanisms is involved in creating large multiresistance genetic elements. The association of the elements with transferable elements or transposons may promote rapid dissemination among clinical strains, and create further opportunities for inclusion of additional resistance determinants. JF - Cellular and Molecular Life Sciences AU - Rice, L B AD - Medical Service 111(W), Louis Stokes VA Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA, louis.rice@med.va.gov Y1 - 2002/12// PY - 2002 DA - Dec 2002 SP - 2023 EP - 2032 VL - 59 IS - 12 SN - 1420-682X, 1420-682X KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - J 02760:Plasmids KW - N 14675:Transposition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18756872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+Molecular+Life+Sciences&rft.atitle=Association+of+different+mobile+elements+to+generate+novel+integrative+elements&rft.au=Rice%2C+L+B&rft.aulast=Rice&rft.aufirst=L&rft.date=2002-12-01&rft.volume=59&rft.issue=12&rft.spage=2023&rft.isbn=&rft.btitle=&rft.title=Cellular+and+Molecular+Life+Sciences&rft.issn=1420682X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Human factors engineering and patient safety AN - 18665065; 5566573 AB - The case study and analyses presented here illustrate the crucial role of human factors engineering (HFE) in patient safety. HFE is a framework for efficient and constructive thinking which includes methods and tools to help healthcare teams perform patient safety analyses, such as root cause analyses. The literature on HFE over several decades contains theories and applied studies to help to solve difficult patient safety problems and design issues. A case study is presented which illustrates the vulnerabilities of human factors design in a transport monitor. The subsequent analysis highlights how to move beyond the more obvious contributing factors like training to design problems and the establishment of informal norms. General advice is offered to address these issues and design issues specific to this case are discussed. JF - Quality & Safety in Health Care AU - Gosbee, J AD - Patient Safely Information Systems, National Center for Patient Safety, Department of Veterans Affairs, 24 Frank Lloyd Wright Drive, Lobby M, Ann Arbor, MI 48106, USA, john.gosbee@med.va.gov Y1 - 2002/12// PY - 2002 DA - Dec 2002 SP - 352 EP - 354 VL - 11 IS - 4 SN - 1475-3898, 1475-3898 KW - safety engineering KW - Health & Safety Science Abstracts KW - H 13000:Medical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18665065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quality+%26+Safety+in+Health+Care&rft.atitle=Human+factors+engineering+and+patient+safety&rft.au=Gosbee%2C+J&rft.aulast=Gosbee&rft.aufirst=J&rft.date=2002-12-01&rft.volume=11&rft.issue=4&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Quality+%26+Safety+in+Health+Care&rft.issn=14753898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Effect of Caffeine on Acetaminophen Hepatotoxicity in Cultured Hepatocytes Treated with Ethanol and Isopentanol AN - 18632720; 5539428 AB - Pretreatment of cultured rat hepatocytes with ethanol alone or in combination with isopentanol, the major higher chain alcohol in alcoholic beverages, significantly increased CYP3A and acetaminophen (APAP) bioactivation, with no increase in APAP toxicity. Caffeine has previously been shown to activate CYP3A activity in vitro and to increase APAP hepatotoxicity in rodents pretreated with prototypic inducers of CYP3A. Here we found that caffeine enhanced APAP toxicity in cultured rat hepatocytes pretreated with the alcohols. The caffeine-mediated increase in APAP toxicity was similar in cells treated with ethanol or isopentanol alone or in combination. These findings suggest that even small increases in CYP3A are sufficient to support caffeine-enhanced APAP toxicity. Triacetyloleandomycin inhibited CYP3A activity in intact hepatocytes and protected alcohol-pretreated cells from caffeine enhancement of APAP toxicity. This protection was associated with decreased formation of the toxic metabolite of APAP. The results indicate that CYP3A is responsible for the caffeine-mediated stimulation of APAP toxicity. Our results suggest that caffeine may be an additional risk factor for developing alcohol-mediated APAP hepatotoxicity. JF - Toxicology and Applied Pharmacology AU - Dipetrillo, K AU - Wood, S AU - Kostrubsky, V AU - Chatfield, K AU - Bement, J AU - Wrighton, S AU - Jeffery, E AU - Sinclair, P AU - Sinclair, J AD - Veterans Administration Medical Center, Department of Pharmacology /Toxicology, Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, 03756 Y1 - 2002/12/01/ PY - 2002 DA - 2002 Dec 01 SP - 91 EP - 97 PB - Academic Press VL - 185 IS - 2 SN - 0041-008X, 0041-008X KW - isopentyl alcohol KW - tissue culture KW - Toxicology Abstracts KW - X 24111:Acute exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18632720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Effect+of+Caffeine+on+Acetaminophen+Hepatotoxicity+in+Cultured+Hepatocytes+Treated+with+Ethanol+and+Isopentanol&rft.au=Dipetrillo%2C+K%3BWood%2C+S%3BKostrubsky%2C+V%3BChatfield%2C+K%3BBement%2C+J%3BWrighton%2C+S%3BJeffery%2C+E%3BSinclair%2C+P%3BSinclair%2C+J&rft.aulast=Dipetrillo&rft.aufirst=K&rft.date=2002-12-01&rft.volume=185&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1006%2Ftaap.2002.9535 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1006/taap.2002.9535 ER - TY - JOUR T1 - Folk yoghurt kills Helicobacter pylori AN - 18618959; 5537206 AB - Aims: To evaluate a traditional yoghurt used as folk medicine for its ability to kill Helicobacter pylori in vitro. Methods and Results: Micro-organisms from the yoghurt were identified and tested in different food substrates for their effects on H. pylori in a co-culture well system. Two yeasts and several strains of lactobacilli were isolated from the yoghurt, and both the yeast and the lactobacilli independently showed cidal activity against H. pylori. The microbes from the original yoghurt also retained their cidal effect when grown in corn meal and soy milk. Conclusions: The yeast and lactobacilli found in this yoghurt form a hardy symbiotic culture. The organisms secrete soluble factors capable of killing H. pylori, and these factors may include some organic by-products of fermentation. Significance and Impact of the Study: These yoghurt-derived food preparations could become simple and inexpensive therapies to suppress H. pylori infections in endemic countries. JF - Journal of Applied Microbiology AU - Oh, Y AU - Osato, M AU - Han, X AU - Bennett, G AU - Hong, W AD - Department of Head & Neck/Thoracic Medical Oncology, M.D. Anderson Cancer Center, Department of Gastroenterology, Veterans Administration Hospital, Department of Microbiology in Laboratory Medicine, M.D. Anderson Cancer Center, Department of Biochemistry, Rice University, and Division of Cancer Medicine, M.D. Anderson Cancer Center, Houston, TX, USA, ywoh@mdanderson.org Y1 - 2002/12// PY - 2002 DA - Dec 2002 SP - 1083 EP - 1088 PB - Blackwell Science Ltd VL - 93 IS - 6 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - A 01017:Human foods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18618959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Folk+yoghurt+kills+Helicobacter+pylori&rft.au=Oh%2C+Y%3BOsato%2C+M%3BHan%2C+X%3BBennett%2C+G%3BHong%2C+W&rft.aulast=Oh&rft.aufirst=Y&rft.date=2002-12-01&rft.volume=93&rft.issue=6&rft.spage=1083&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1046%2Fj.1365-2672.2002.01779.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1046/j.1365-2672.2002.01779.x ER - TY - JOUR T1 - Amino Acid Substitutions at Ambler Position Gly238 in the SHV-1 beta - Lactamase: Exploring Sequence Requirements for Resistance to Penicillins and Cephalosporins AN - 18533777; 5490426 AB - Site saturation mutagenesis of the 238 position in the SHV beta -lactamase was performed to identify the complete sequence requirements needed for the extended spectrum beta -lactamase (ESBL) phenotype. MICs (in micrograms per milliliter) in an isogenic background, Escherichia coli DH10B, demonstrated that the Gly238Ala mutation conferred the most resistance to penicillins and cephalosporins. The absolute increase in resistance was greatest against cefotaxime for the Gly238Ala mutant (0.06 to 8 mu g/ml). Except for the strain possessing the Gly238Pro beta -lactamase, ceftazidime MICs were also elevated. None of the mutant SHV beta -lactamases were expressed in as great an amount as the wild-type beta -lactamase. Kinetic analysis of the Gly238Ala mutant revealed that penicillin and cephalosporin substrates have a lower K sub(m) for the enzyme because of this mutation. Ampicillin and piperacillin MICs were inversely proportional to the side chain volume of the amino acid in cases larger than Ser, suggesting that steric considerations may be a primary requirement for penicillin resistance. Secondary structural effects explain increased resistance to oxyiminocephalosporins. Based upon this study, we anticipate that additional mutations of Gly238 in the SHV beta -lactamase will continue to be discovered with an ESBL (ceftazidime or cefotaxime resistant) phenotype. JF - Antimicrobial Agents & Chemotherapy AU - Hujer, AM AU - Hujer, K M AU - Helfand AU - Anderson, V E AU - Bonomo, R A AD - Infectious Disease Section, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Blvd., Cleveland, OH 44106, robert.bonomo@med.va.gov Y1 - 2002/12// PY - 2002 DA - Dec 2002 SP - 3971 EP - 3977 VL - 46 IS - 12 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18533777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Amino+Acid+Substitutions+at+Ambler+Position+Gly238+in+the+SHV-1+beta+-+Lactamase%3A+Exploring+Sequence+Requirements+for+Resistance+to+Penicillins+and+Cephalosporins&rft.au=Hujer%2C+AM%3BHujer%2C+K+M%3BHelfand%3BAnderson%2C+V+E%3BBonomo%2C+R+A&rft.aulast=Hujer&rft.aufirst=AM&rft.date=2002-12-01&rft.volume=46&rft.issue=12&rft.spage=3971&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.46.12.3971-3977.2002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1128/AAC.46.12.3971-3977.2002 ER - TY - JOUR T1 - Inflammatory mediators and the failing heart: past, present, and the foreseeable future. AN - 72717605; 12456484 AB - Recent studies have identified the importance of proinflammatory mediators in the development and progression of heart failure. The growing appreciation of the pathophysiological consequences of sustained expression of proinflammatory mediators in preclinical and clinical heart failure models culminated in a series of multicenter clinical trials that used "targeted" approaches to neutralize tumor necrosis factor in patients with moderate to advanced heart failure. However, these targeted approaches have resulted in worsening heart failure, thereby raising a number of important questions about what role, if any, proinflammatory cytokines play in the pathogenesis of heart failure. This review will summarize the tremendous growth of knowledge that has taken place in this field, with a focus on what we have learned from the negative clinical trials, as well as the potential direction of future research in this area. JF - Circulation research AU - Mann, Douglas L AD - Winters Center for Heart Failure Research, the Cardiology Section, Department of Medicine, Veterans Administration Medical Center, Methodist Hospital, and Baylor College of Medicine, Houston, Tex 77030, USA. dmann@bcm.tmc.edu Y1 - 2002/11/29/ PY - 2002 DA - 2002 Nov 29 SP - 988 EP - 998 VL - 91 IS - 11 KW - Antibodies, Monoclonal KW - 0 KW - Antirheumatic Agents KW - Cytokines KW - Immunoglobulin G KW - Immunologic Factors KW - Inflammation Mediators KW - Receptors, Tumor Necrosis Factor KW - Tumor Necrosis Factor-alpha KW - Thalidomide KW - 4Z8R6ORS6L KW - Infliximab KW - B72HH48FLU KW - Etanercept KW - OP401G7OJC KW - Pentoxifylline KW - SD6QCT3TSU KW - Index Medicus KW - Animals KW - Treatment Failure KW - Ventricular Dysfunction, Left -- etiology KW - Humans KW - Disease Progression KW - Endothelium, Vascular -- physiopathology KW - Research -- trends KW - Antibodies, Monoclonal -- therapeutic use KW - Pentoxifylline -- adverse effects KW - Endothelium, Vascular -- drug effects KW - Pentoxifylline -- therapeutic use KW - Receptors, Tumor Necrosis Factor -- therapeutic use KW - Antirheumatic Agents -- therapeutic use KW - Immunologic Factors -- adverse effects KW - Ventricular Function, Left -- drug effects KW - Immunoglobulin G -- adverse effects KW - Cytokines -- pharmacology KW - Thalidomide -- adverse effects KW - Clinical Trials as Topic KW - Cytokines -- metabolism KW - Cytokines -- antagonists & inhibitors KW - Ventricular Dysfunction, Left -- physiopathology KW - Immunoglobulin G -- therapeutic use KW - Immunologic Factors -- therapeutic use KW - Antirheumatic Agents -- adverse effects KW - Tumor Necrosis Factor-alpha -- antagonists & inhibitors KW - Antibodies, Monoclonal -- adverse effects KW - Thalidomide -- therapeutic use KW - Tumor Necrosis Factor-alpha -- metabolism KW - Heart Failure -- etiology KW - Heart Failure -- drug therapy KW - Inflammation Mediators -- pharmacology KW - Heart Failure -- physiopathology KW - Inflammation Mediators -- metabolism KW - Inflammation Mediators -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72717605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation+research&rft.atitle=Inflammatory+mediators+and+the+failing+heart%3A+past%2C+present%2C+and+the+foreseeable+future.&rft.au=Mann%2C+Douglas+L&rft.aulast=Mann&rft.aufirst=Douglas&rft.date=2002-11-29&rft.volume=91&rft.issue=11&rft.spage=988&rft.isbn=&rft.btitle=&rft.title=Circulation+research&rft.issn=1524-4571&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-12-09 N1 - Date created - 2002-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chant Therapy for Treating Vocal Fatigue among Public School Teachers: A Preliminary Study AN - 85621184; 200608130 AB - Voice therapies have proven to be an effective method of helping patients avoid the symptoms of vocal fatigue. This study assesses the effect of a chant-based therapy on self-perceptive symptoms of vocal fatigue. A recitational pattern was selected & a therapy regime created from important features of this chant. It was administered along with a placebo therapy to four public school teachers who were prone to vocal fatigue. A two-hour fatiguing task was administered pre- & post-therapies, during which self-evaluative measures of "vocal effort" & "voice quality" were made by the subjects. The plots of these measures were used for the purpose of determining the effects of the chant therapy. Based on changes in the subjects' responses to the fatiguing task after the delivery of the chant therapy, we concluded that this form of functional therapy has the potential to be effective in the remediation of vocal fatigue. Adapted from the source document JF - American Journal of Speech-Language Pathology AU - McCabe, Daniel J AU - Titze, Ingo R AD - U Iowa, Iowa City Dan.McCabe@med.va.gov Y1 - 2002/11// PY - 2002 DA - November 2002 SP - 356 EP - 369 VL - 11 IS - 4 SN - 1058-0360, 1058-0360 KW - Singing (78950) KW - Teachers (87860) KW - Voice Quality (95200) KW - Vocalization (94910) KW - Voice Disorders (95150) KW - Speech Therapy (83200) KW - article KW - 6812: special education; language therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85621184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Speech-Language+Pathology&rft.atitle=Chant+Therapy+for+Treating+Vocal+Fatigue+among+Public+School+Teachers%3A+A+Preliminary+Study&rft.au=McCabe%2C+Daniel+J%3BTitze%2C+Ingo+R&rft.aulast=McCabe&rft.aufirst=Daniel&rft.date=2002-11-01&rft.volume=11&rft.issue=4&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Speech-Language+Pathology&rft.issn=10580360&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2006-07-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJSPFZ N1 - SubjectsTermNotLitGenreText - Teachers (87860); Singing (78950); Vocalization (94910); Voice Disorders (95150); Voice Quality (95200); Speech Therapy (83200) ER - TY - JOUR T1 - Lansoprazole-associated microscopic colitis: a case series. AN - 85361105; pmid-12425567 AB - Lansoprazole is a potent proton pump inhibitor that has been well tolerated with minimal serious adverse events. One of the most commonly reported side effects is diarrhea in 3-8% of study patients. During 1997, approximately 850 veterans at our institution had their proton pump inhibitor converted from omeprazole to lansoprazole because of a formulary change. A number of patients subsequently developed chronic watery diarrhea. While evaluating six of these patients, we discovered microscopic colitis that resolved with discontinuation of lansoprazole. The diarrhea was described as three to 10 loose, nonbloody bowel movements per day with some abdominal cramping. Colonoscopy in five patients and flexible sigmoidoscopy in one patient revealed normal colonic mucosa, but random biopsies all supported microscopic colitis (five cases of lymphocytic colitis and one case of collagenous colitis). Complete symptom resolution occurred in all patients within 4 to 10 days of discontinuing lansoprazole. In all patients, follow-up biopsies demonstrated normalization of the colonic histology. This is the first published case series of patients with microscopic colitis that correlated clinically and histologically with the initiation and discontinuation of lansoprazole. JF - The American journal of gastroenterology AU - Thomson, Robert D AU - Lestina, Lisa S AU - Bensen, Steven P AU - Toor, Arifa AU - Maheshwari, Yogesh AU - Ratcliffe, Nora R AD - Department of Pathology, Veterans Administration Medical Center, Dartmouth Medical School, White River Junction, Vermont 05001, USA. Y1 - 2002/11// PY - 2002 DA - Nov 2002 SP - 2908 EP - 2913 VL - 97 IS - 11 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - 2-Pyridinylmethylsulfinylbenzimidazoles KW - Aged KW - Anti-Infective Agents: adverse effects KW - Anti-Ulcer Agents: adverse effects KW - *Colitis: chemically induced KW - Colitis: complications KW - *Colitis: pathology KW - Colonoscopy KW - Diarrhea: etiology KW - Enzyme Inhibitors: adverse effects KW - Humans KW - Male KW - Middle Aged KW - Omeprazole: administration & dosage KW - *Omeprazole: adverse effects KW - *Omeprazole: analogs & derivatives KW - *Proton Pumps: antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85361105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Lansoprazole-associated+microscopic+colitis%3A+a+case+series.&rft.au=Thomson%2C+Robert+D%3BLestina%2C+Lisa+S%3BBensen%2C+Steven+P%3BToor%2C+Arifa%3BMaheshwari%2C+Yogesh%3BRatcliffe%2C+Nora+R&rft.aulast=Thomson&rft.aufirst=Robert&rft.date=2002-11-01&rft.volume=97&rft.issue=11&rft.spage=2908&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Efficacy of combined radiation, paclitaxel and carboplatin for locally advanced non-small cell lung carcinoma. AN - 72832188; 12552935 AB - Locally advanced non-small cell lung carcinoma (NSCLC) has a poor prognosis when treated with conventional chemotherapy and radiation. New chemotherapy agents like paclitaxel may increase the sensitivity of tumors cells to radiation and potentially improve the outcome. The optimal combination of taxane-based chemotherapy agents and radiation is still unclear. We investigated the feasibility of induction chemotherapy followed by concurrent near systemic dose of chemotherapy with radiation. A prospective survey of 29 previously untreated patients with unresectable stage III (15 IIIA, 14 IIIB) NSCLC treated with paclitaxel and carboplatin in combination with radiation was reviewed. The patients received 2 cycles of paclitaxel 225 mg/m2 intravenously (i.v.) over 3 hours, days 1, 22; carboplatin at area under the curve (AUC) 6 based on Calvert formula days 1, 22 following completion of the paclitaxel infusion. Following induction chemotherapy, radiation therapy started on day 43 until completion to a tumor dose of at least 5960 cGy. Cycles 3 and 4 of chemotherapy were begun on days 43 and 63, respectively, and consisted of paclitaxel 175 mg/m2 i.v. over 3 hours, and carboplatin at AUC 6 following paclitaxel infusion. The response rate, acute toxicity, long-term complications, pattern of failure and survival were evaluated and compared to previous studies in the literature. Two patients were lost to follow-up. The response rate to induction carboplatin/paclitaxel was 52%. An overall response rate (complete and partial responders) of 85% was obtained following chemotherapy and radiation. Grade 3-4 acute side-effects were recorded in 9 patients (31%) and consisted of esophagitis (8 patients) and anemia (1 patient). One patient died from cachexia 3 months following treatment (3.7%). The median survival and 3-year survival were 15 months and 30%, respectively, for the remaining 27 patients at a median follow-up of 11 months. There was no difference in survival between stages IIIA and IIIB at 2 years (IIIA: 22%, IIIB: 31%). Local or regional recurrences and distant metastases developed in 9 patients (33%) and 13 patients (46%), respectively. The combination of paclitaxel, carboplatin and radiation for locally advanced non-small cell carcinoma is feasible with acceptable toxicity. The response rate compares favorably with previously reported studies. The decrease of tumor volume following induction chemotherapy allows sparing of the lungs from the toxicity of radiation. However, grades 3-4 esophagitis remain significant. The addition of amifostine may be beneficial in this setting. JF - Anticancer research AU - Nguyen, Nam P AU - Leonardo, James M AU - Karlsson, Ulf AU - Vos, Paul AU - Bullock, Laurie AU - Thomas, Patricia AU - Lepera, Pamela AU - Ludin, Adir AU - Chu, Colin AU - Salehpour, Mohammad AU - Jendrasiak, Gordon AU - Sallah, Sabah AD - Department of Radiation Oncology, Southwestern University, VA North Texas Health Care System, 4500 S Lancaster Road, Dallas, TX 75216, USA. NamPhong.Nguyen@med.va.gov PY - 2002 SP - 3429 EP - 3435 VL - 22 IS - 6B SN - 0250-7005, 0250-7005 KW - Carboplatin KW - BG3F62OND5 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Paclitaxel -- adverse effects KW - Combined Modality Therapy KW - Humans KW - Aged KW - Middle Aged KW - Carboplatin -- adverse effects KW - Carboplatin -- administration & dosage KW - Male KW - Female KW - Survival Analysis KW - Radiotherapy -- adverse effects KW - Lung Neoplasms -- radiotherapy KW - Lung Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Carcinoma, Non-Small-Cell Lung -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72832188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+research&rft.atitle=Efficacy+of+combined+radiation%2C+paclitaxel+and+carboplatin+for+locally+advanced+non-small+cell+lung+carcinoma.&rft.au=Nguyen%2C+Nam+P%3BLeonardo%2C+James+M%3BKarlsson%2C+Ulf%3BVos%2C+Paul%3BBullock%2C+Laurie%3BThomas%2C+Patricia%3BLepera%2C+Pamela%3BLudin%2C+Adir%3BChu%2C+Colin%3BSalehpour%2C+Mohammad%3BJendrasiak%2C+Gordon%3BSallah%2C+Sabah&rft.aulast=Nguyen&rft.aufirst=Nam&rft.date=2002-11-01&rft.volume=22&rft.issue=6B&rft.spage=3429&rft.isbn=&rft.btitle=&rft.title=Anticancer+research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-02-24 N1 - Date created - 2003-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Psychiatric comorbidity, continuing care and mutual help as predictors of five-year remission from substance use disorders. AN - 72821730; 12529071 AB - In a cohort of 2,595 male patients in VA intensive treatment programs for substance use disorders (SUD), we tested whether psychiatric comorbidity, outpatient care and mutual help group attendance during the first two follow-up years predicted remission status at Year 5, controlling for covariates. Logistic regression modeling of longitudinal data was used to test the hypotheses. Dual diagnosis patients were less likely to be in remission at Year 5 than SUD-only patients. Outpatient care was at best only weakly related to Year 5 remission status. By contrast, mutual help involvement substantially improved the chances of substance use remission at Year 5 for both SUD-only and dual diagnosis patients. Mutual help involvement did not, however, offset the poorer prognosis for dual diagnosis patients. Because mutual help groups specifically targeted to individuals with comorbid substance use and psychiatric disorders are currently rare, further research is recommended to investigate whether they are more effective than standard SUD mutual help groups in facilitating the recovery of persons with dual diagnoses. JF - Journal of studies on alcohol AU - Ritsher, Jennifer Boyd AU - McKellar, John D AU - Finney, John W AU - Otilingam, Poorni G AU - Moos, Rudolf H AD - Center for Health Care Evaluation, Veterans Affairs Palo Alto Health Care System, & Stanford University School of Medicine, Palo Alto, California, USA. jennifer.ritsher@med.va.gov Y1 - 2002/11// PY - 2002 DA - November 2002 SP - 709 EP - 715 VL - 63 IS - 6 SN - 0096-882X, 0096-882X KW - Index Medicus KW - Long-Term Care -- trends KW - Diagnosis, Dual (Psychiatry) -- trends KW - Chi-Square Distribution KW - Humans KW - Diagnosis, Dual (Psychiatry) -- psychology KW - Diagnosis, Dual (Psychiatry) -- statistics & numerical data KW - Comorbidity -- trends KW - Logistic Models KW - Adult KW - Cohort Studies KW - Middle Aged KW - Long-Term Care -- statistics & numerical data KW - Follow-Up Studies KW - Forecasting KW - Long-Term Care -- psychology KW - Male KW - Substance-Related Disorders -- therapy KW - Self-Help Groups -- trends KW - Self-Help Groups -- statistics & numerical data KW - Mental Disorders -- therapy KW - Mental Disorders -- epidemiology KW - Mental Disorders -- psychology KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72821730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+studies+on+alcohol&rft.atitle=Psychiatric+comorbidity%2C+continuing+care+and+mutual+help+as+predictors+of+five-year+remission+from+substance+use+disorders.&rft.au=Ritsher%2C+Jennifer+Boyd%3BMcKellar%2C+John+D%3BFinney%2C+John+W%3BOtilingam%2C+Poorni+G%3BMoos%2C+Rudolf+H&rft.aulast=Ritsher&rft.aufirst=Jennifer&rft.date=2002-11-01&rft.volume=63&rft.issue=6&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=Journal+of+studies+on+alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-08 N1 - Date created - 2003-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethanol promotes intestinal tumorigenesis in the MIN mouse. Multiple intestinal neoplasia. AN - 72692545; 12433735 AB - Epidemiological studies suggest that alcohol consumption increases the risk of developing colorectal cancer; however, these data are confounded by numerous cosegregating variables. Previous experimental reports with the rodent carcinogen model have also yielded discordant results. To clarify the alcohol-colon cancer relationship, we used the MIN (multiple intestinal neoplasia) mouse, a genetic model of intestinal tumorigenesis. Twenty-four MIN mice were randomized to ethanol supplementation in the drinking water (15% alternating with 20% on a daily basis) or control. Mice were sacrificed after 10 weeks, and the intestinal tumors were scored under magnification. Tissue sections were assessed for apoptosis and cell proliferation rates, along with the presence of the malondialdehyde-acetaldehyde (MAA) adduct, a mutagenic adduct associated with ethanol consumption. Ethanol supplementation resulted in a significant increase in tumor number (135 +/- 35%; P = 0.027 versus control). The induction of tumorigenesis by ethanol was most dramatic in the distal small bowel (167 +/- 56%; P = 0.01). In the uninvolved intestinal mucosa, there was no difference in proliferative or apoptotic indices. Cytoplasmic and nuclear MAA adducts were detected in both ethanol-treated and control mice. We demonstrated that ethanol ingestion increased intestinal tumorigenesis in the MIN mouse model. Furthermore, whereas mechanisms remain incompletely elucidated, our data implicate formation of MAA adducts. This report provides further support that ethanol consumption is a risk factor for colorectal cancer. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Roy, Hemant K AU - Gulizia, James M AU - Karolski, William J AU - Ratashak, Anne AU - Sorrell, Michael F AU - Tuma, Dean AD - Department of Internal Medicine, University of Nebraska Medical Center and Omaha Veterans Administration Medical Center, Omaha, Nebraska, USA. h-roy@northwestern.edu Y1 - 2002/11// PY - 2002 DA - November 2002 SP - 1499 EP - 1502 VL - 11 IS - 11 SN - 1055-9965, 1055-9965 KW - Biomarkers, Tumor KW - 0 KW - Proliferating Cell Nuclear Antigen KW - Ethanol KW - 3K9958V90M KW - Malondialdehyde KW - 4Y8F71G49Q KW - DNA Nucleotidylexotransferase KW - EC 2.7.7.31 KW - Acetaldehyde KW - GO1N1ZPR3B KW - Index Medicus KW - Intestinal Mucosa -- cytology KW - Rodentia -- immunology KW - Malondialdehyde -- immunology KW - Animals KW - Rodentia -- metabolism KW - Biomarkers, Tumor -- immunology KW - Acetaldehyde -- immunology KW - Apoptosis -- physiology KW - Proliferating Cell Nuclear Antigen -- drug effects KW - Intestinal Mucosa -- metabolism KW - Disease Models, Animal KW - Mice KW - Acetaldehyde -- metabolism KW - Proliferating Cell Nuclear Antigen -- biosynthesis KW - Malondialdehyde -- metabolism KW - Biomarkers, Tumor -- metabolism KW - Mice, Mutant Strains KW - Cell Differentiation -- physiology KW - DNA Nucleotidylexotransferase -- drug effects KW - Mice, Inbred C57BL KW - DNA Nucleotidylexotransferase -- metabolism KW - Antibody Specificity -- immunology KW - Immunohistochemistry KW - Male KW - Ethanol -- adverse effects KW - Abnormalities, Multiple -- physiopathology KW - Intestinal Neoplasms -- chemically induced KW - Abnormalities, Multiple -- immunology KW - Intestinal Neoplasms -- physiopathology KW - Intestinal Neoplasms -- immunology KW - Abnormalities, Multiple -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72692545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Ethanol+promotes+intestinal+tumorigenesis+in+the+MIN+mouse.+Multiple+intestinal+neoplasia.&rft.au=Roy%2C+Hemant+K%3BGulizia%2C+James+M%3BKarolski%2C+William+J%3BRatashak%2C+Anne%3BSorrell%2C+Michael+F%3BTuma%2C+Dean&rft.aulast=Roy&rft.aufirst=Hemant&rft.date=2002-11-01&rft.volume=11&rft.issue=11&rft.spage=1499&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-07 N1 - Date created - 2002-11-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Circadian variation of topoisomerase II-alpha in human rectal crypt epithelium: implications for reduction of toxicity of chemotherapy. AN - 72689486; 12429798 AB - Topoisomerase II-alpha is a target of common chemotherapeutic agents such as doxorubicin and etoposide, which induce DNA damage by altering the activity of this enzyme. We took rectal biopsies at 4-hour intervals over a 24-hour period (seven total) from each of 10 healthy volunteers and examined immunoperoxidase-stained coded anti-topoisomerase II-alpha-stained sections. A significant circadian periodicity was seen in the number of rectal crypt epithelial cell nuclei that were stained (P =.01). Mean peak staining was at 7:23 a.m. +/- 45 minutes, and the mean rate of change (difference between peak and trough expression) was 40%. Topoisomerase II-alpha expression in rectal epithelium has a significant circadian variation similar to that of tritiated thymidine incorporation. Although direct confirmation is needed, giving topoisomerase II-targeted chemotherapeutic agents at the proper time of day might reduce their mucositis side effects. JF - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc AU - Clayton, Frederic AU - Tessnow, Kathryn A AU - Fang, John C AU - Holden, Joseph A AU - Moore, John G AD - Department of Pathology, Salt Lake Veterans Administration Hospital, Salt Lake City, Utah 84148, USA. Y1 - 2002/11// PY - 2002 DA - November 2002 SP - 1191 EP - 1196 VL - 15 IS - 11 SN - 0893-3952, 0893-3952 KW - Antigens, Neoplasm KW - 0 KW - Antineoplastic Agents KW - DNA-Binding Proteins KW - DNA Topoisomerases, Type II KW - EC 5.99.1.3 KW - DNA topoisomerase II alpha KW - Index Medicus KW - Humans KW - Chronotherapy -- methods KW - Adult KW - Epithelium -- enzymology KW - Antineoplastic Agents -- therapeutic use KW - Adolescent KW - Immunohistochemistry KW - Male KW - DNA Topoisomerases, Type II -- biosynthesis KW - Rectum -- enzymology KW - Circadian Rhythm -- physiology KW - DNA Topoisomerases, Type II -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72689486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Modern+pathology+%3A+an+official+journal+of+the+United+States+and+Canadian+Academy+of+Pathology%2C+Inc&rft.atitle=Circadian+variation+of+topoisomerase+II-alpha+in+human+rectal+crypt+epithelium%3A+implications+for+reduction+of+toxicity+of+chemotherapy.&rft.au=Clayton%2C+Frederic%3BTessnow%2C+Kathryn+A%3BFang%2C+John+C%3BHolden%2C+Joseph+A%3BMoore%2C+John+G&rft.aulast=Clayton&rft.aufirst=Frederic&rft.date=2002-11-01&rft.volume=15&rft.issue=11&rft.spage=1191&rft.isbn=&rft.btitle=&rft.title=Modern+pathology+%3A+an+official+journal+of+the+United+States+and+Canadian+Academy+of+Pathology%2C+Inc&rft.issn=08933952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-07 N1 - Date created - 2002-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): phase II viral, immunologic, and clinical endpoints. AN - 72643892; 12414631 AB - Replication-selective oncolytic adenoviruses are being developed for the treatment of cancer, but the safety and feasibility of repeated adenovirus delivery to tumors via the bloodstream was unknown, particularly in light of a patient death after hepatic artery infusion of a replication-defective adenovirus vector. We performed a Phase II trial of an oncolytic replication-selective adenovirus (dl1520, also known as Onyx-015) administered by hepatic artery infusion in patients with gastrointestinal carcinoma metastatic to the liver (n = 27). dl1520 was infused into the hepatic artery (2 x 10(12) particles) on days 1 and 8 as a single agent, and thereafter starting on day 22 in combination with i.v. 5-fluorouracil and leucovorin every 28 days. Repeated viral infusions were feasible, and no deaths occurred on study; reversible grade 3/4 hyperbilirubinemia occurred in 2 patients. Systemic inflammatory cytokine responses varied greatly between patients and even between cycles within a given patient. Proinflammatory cytokines [e.g., tumor necrosis factor, IFN-gamma, and interleukin (IL) 6] typically rose within 3 h and were followed at 18 h by a rise in IL-10. However, in the single patient who suffered a severe but reversible systemic inflammatory response, a unique cytokine profile was detected: marked acute increases of IL-6 (20-fold higher than average for all of the patients) and inhibition of IL-10 production. Delayed secondary peaks of viremia were reproducibly detected 3-6 days after treatment, even in the presence of high level neutralizing antibody titers and antiviral cytokines. Mathematical modeling was used to calculate the number of virus particles produced and shed into the blood with each replication cycle. The combination of virotherapy and chemotherapy had antitumoral activity in some chemotherapy-resistant colorectal tumors. The intra-arterial infusion of oncolytic adenoviruses warrants additional study. JF - Cancer research AU - Reid, Tony AU - Galanis, Eva AU - Abbruzzese, James AU - Sze, Dan AU - Wein, Lawrence M AU - Andrews, James AU - Randlev, Britta AU - Heise, Carla AU - Uprichard, Margaret AU - Hatfield, Michael AU - Rome, Larry AU - Rubin, Joseph AU - Kirn, David AD - Palo Alto Veterans Administration Hospital and Stanford University Medical Center, California 94305, USA. Y1 - 2002/11/01/ PY - 2002 DA - 2002 Nov 01 SP - 6070 EP - 6079 VL - 62 IS - 21 SN - 0008-5472, 0008-5472 KW - Antibodies, Viral KW - 0 KW - Cytokines KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Virus Replication KW - Infusions, Intra-Arterial KW - Hepatic Artery KW - Combined Modality Therapy KW - Leucovorin -- administration & dosage KW - Cytokines -- biosynthesis KW - Humans KW - Cytokines -- immunology KW - Aged KW - Genome, Viral KW - Antibodies, Viral -- biosynthesis KW - Fluorouracil -- administration & dosage KW - Adult KW - Middle Aged KW - Male KW - Female KW - Colorectal Neoplasms -- pathology KW - Liver Neoplasms -- drug therapy KW - Adenoviruses, Human -- genetics KW - Liver Neoplasms -- virology KW - Colorectal Neoplasms -- immunology KW - Adenoviruses, Human -- physiology KW - Colorectal Neoplasms -- virology KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Liver Neoplasms -- secondary KW - Colorectal Neoplasms -- drug therapy KW - Liver Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72643892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Hepatic+arterial+infusion+of+a+replication-selective+oncolytic+adenovirus+%28dl1520%29%3A+phase+II+viral%2C+immunologic%2C+and+clinical+endpoints.&rft.au=Reid%2C+Tony%3BGalanis%2C+Eva%3BAbbruzzese%2C+James%3BSze%2C+Dan%3BWein%2C+Lawrence+M%3BAndrews%2C+James%3BRandlev%2C+Britta%3BHeise%2C+Carla%3BUprichard%2C+Margaret%3BHatfield%2C+Michael%3BRome%2C+Larry%3BRubin%2C+Joseph%3BKirn%2C+David&rft.aulast=Reid&rft.aufirst=Tony&rft.date=2002-11-01&rft.volume=62&rft.issue=21&rft.spage=6070&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-12-10 N1 - Date created - 2002-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. AN - 72640341; 12379862 AB - In animals, exposure to severe stress can damage the hippocampus. Recent human studies show smaller hippocampal volume in individuals with the stress-related psychiatric condition posttraumatic stress disorder (PTSD). Does this represent the neurotoxic effect of trauma, or is smaller hippocampal volume a pre-existing condition that renders the brain more vulnerable to the development of pathological stress responses? In monozygotic twins discordant for trauma exposure, we found evidence that smaller hippocampi indeed constitute a risk factor for the development of stress-related psychopathology. Disorder severity in PTSD patients who were exposed to trauma was negatively correlated with the hippocampal volume of both the patients and the patients' trauma-unexposed identical co-twin. Furthermore, severe PTSD twin pairs-both the trauma-exposed and unexposed members-had significantly smaller hippocampi than non-PTSD pairs. JF - Nature neuroscience AU - Gilbertson, Mark W AU - Shenton, Martha E AU - Ciszewski, Aleksandra AU - Kasai, Kiyoto AU - Lasko, Natasha B AU - Orr, Scott P AU - Pitman, Roger K AD - Research Service, Veterans Administration Medical Center, 718 Smyth Road, Manchester, New Hampshire 03104, USA. mark.gilbertson@med.va.gov Y1 - 2002/11// PY - 2002 DA - November 2002 SP - 1242 EP - 1247 VL - 5 IS - 11 SN - 1097-6256, 1097-6256 KW - Index Medicus KW - Alcoholism -- epidemiology KW - Twins, Monozygotic KW - Risk Factors KW - Humans KW - Middle Aged KW - Combat Disorders -- epidemiology KW - Male KW - Comorbidity KW - Combat Disorders -- pathology KW - Substance-Related Disorders -- epidemiology KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Hippocampus -- abnormalities KW - Stress Disorders, Post-Traumatic -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72640341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+neuroscience&rft.atitle=Smaller+hippocampal+volume+predicts+pathologic+vulnerability+to+psychological+trauma.&rft.au=Gilbertson%2C+Mark+W%3BShenton%2C+Martha+E%3BCiszewski%2C+Aleksandra%3BKasai%2C+Kiyoto%3BLasko%2C+Natasha+B%3BOrr%2C+Scott+P%3BPitman%2C+Roger+K&rft.aulast=Gilbertson&rft.aufirst=Mark&rft.date=2002-11-01&rft.volume=5&rft.issue=11&rft.spage=1242&rft.isbn=&rft.btitle=&rft.title=Nature+neuroscience&rft.issn=10976256&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-12-05 N1 - Date created - 2002-10-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cogn Neurosci. 2000 Jan;12(1):223-32 [10769318] Am J Psychiatry. 2000 May;157(5):737-44 [10784466] Behav Brain Res. 2000 May;109(2):177-86 [10762687] J Abnorm Psychol. 2000 May;109(2):290-8 [10895567] J Abnorm Psychol. 2001 Feb;110(1):40-8 [11261398] Hippocampus. 2001;11(2):73-4; discusion 82-4 [11345126] Hippocampus. 2001;11(2):75-81; discussion 82-4 [11345127] Am J Psychiatry. 2000 Jan;157(1):115-8 [10618023] Clin Genet. 1989 Jun;35(6):423-32 [2736790] J Neurosci. 1999 Jun 15;19(12):5034-43 [10366636] Biol Psychiatry. 1999 May 15;45(10):1271-84 [10349033] Magn Reson Med. 1998 Jul;40(1):66-71 [9660555] Ann N Y Acad Sci. 1997 Jun 21;821:516-20 [9238242] Ann N Y Acad Sci. 1997 Jun 21;821:24-34 [9238191] Psychol Med. 1997 Jul;27(4):951-9 [9234472] Biol Psychiatry. 1997 Jan 1;41(1):23-32 [8988792] Biol Psychiatry. 1996 Dec 1;40(11):1091-9 [8931911] Arch Gen Psychiatry. 1995 Dec;52(12):1048-60 [7492257] Am J Psychiatry. 1995 Jul;152(7):973-81 [7793467] Neuron. 1995 Apr;14(4):717-30 [7718235] J Trauma Stress. 1995 Jan;8(1):75-90 [7712061] Annu Rev Neurosci. 1993;16:547-63 [8460903] Hippocampus. 2001;11(2):85-9; discussion 82-4 [11345128] Am J Psychiatry. 2001 Aug;158(8):1248-51 [11481158] Nat Neurosci. 2001 Dec;4(12):1253-8 [11694885] Arch Gen Psychiatry. 2001 Dec;58(12):1145-51 [11735843] Biol Psychiatry. 2001 Dec 15;50(12):952-9 [11750891] Arch Gen Psychiatry. 2003 Mar;60(3):283-8 [12622661] J Comp Physiol Psychol. 1971 Jul;76(1):57-65 [5559608] Am J Psychiatry. 1971 Jun;127(12):1653-8 [5565851] Physiol Behav. 1972 Jul;9(1):15-20 [4342937] Brain Res. 1981 Aug;254(1):129-40 [7272765] Behav Brain Res. 1983 Jan;7(1):1-38 [6824524] Acta Genet Med Gemellol (Roma). 1987;36(1):61-6 [3673478] Behav Brain Res. 1989 Feb 1;32(1):81-8 [2930637] Public Health Rep. 1990 Jul-Aug;105(4):368-73 [2116638] J Neurosci. 1990 Sep;10(9):2897-902 [2398367] J Clin Psychol. 1991 Jan;47(1):80-6 [2026782] Neuroscience. 1991;42(2):335-50 [1832750] Am J Psychiatry. 1992 May;149(5):671-5 [1575259] Behav Neurosci. 1992 Apr;106(2):274-85 [1590953] Psychol Rev. 1992 Apr;99(2):195-231 [1594723] N Engl J Med. 1992 Aug 27;327(9):604-12 [1640954] Am J Psychiatry. 1992 Nov;149(11):1568-74 [1415826] Comment In: Nat Neurosci. 2002 Nov;5(11):1111-3 [12404003] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Linking mental health and addiction services: a continuity-of-care team model. AN - 72636703; 12404937 AB - Reorganization of mental health care delivery services at a Department of Veterans Affairs medical center addressed problems with the coordination of addiction treatment and mental health programming for patients with significant psychiatric and addiction comorbidity. Clinical services were organized into interdisciplinary continuity-of-care teams that follow patients across different levels of care. The teams provide addiction treatment through "universally available" resources such as a partial hospital addiction rehabilitation module. Continuity of care remains within the team structure as clinicians follow patients throughout their rehabilitation course. Patient and staff satisfaction focus on improved accessibility of addiction services and continuity of care providers across time and levels of care. Overall inpatient utilization and recidivism decreased after model implementation. JF - The journal of behavioral health services & research AU - Lambert, Michael T AD - Mental Health Service 116A, VANTHCS, Department of Psychiatry, University of Texas Southwestern Medical School at Dallas, USA. Michael.Lambert2@med.va.gov Y1 - 2002/11// PY - 2002 DA - November 2002 SP - 433 EP - 444 VL - 29 IS - 4 SN - 1094-3412, 1094-3412 KW - Index Medicus KW - United States KW - Patient Readmission -- statistics & numerical data KW - Patient Discharge -- statistics & numerical data KW - Hospital Restructuring KW - United States Department of Veterans Affairs KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Texas KW - Program Evaluation KW - Models, Organizational KW - Psychiatric Department, Hospital -- utilization KW - Psychiatric Department, Hospital -- organization & administration KW - Continuity of Patient Care -- organization & administration KW - Substance Abuse Treatment Centers -- organization & administration KW - Patient Care Team KW - Hospitals, Veterans -- organization & administration KW - Substance-Related Disorders -- rehabilitation KW - Substance Abuse Treatment Centers -- utilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72636703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+behavioral+health+services+%26+research&rft.atitle=Linking+mental+health+and+addiction+services%3A+a+continuity-of-care+team+model.&rft.au=Lambert%2C+Michael+T&rft.aulast=Lambert&rft.aufirst=Michael&rft.date=2002-11-01&rft.volume=29&rft.issue=4&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=The+journal+of+behavioral+health+services+%26+research&rft.issn=10943412&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-11-25 N1 - Date created - 2002-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oral arginine does not stimulate an increase in insulin concentration but delays glucose disposal. AN - 72628141; 12399273 AB - Ingested protein increases circulating insulin concentrations. Several years ago it was also determined that an intravenously administered mixture of 10 essential amino acids stimulated insulin secretion. Of these, arginine was the most potent. The effect was synergistic with administered glucose. Because the amounts of amino acid administered intravenously were very large and because ingested arginine is partially metabolized in the intestinal mucosa, we were interested in determining whether orally administered arginine stimulates a rise in circulating insulin concentration and whether arginine affects the glucose-induced rise in insulin concentration. Nine healthy subjects (4 women and 5 men aged 21-52 y) ingested 1 mmol arginine/kg lean body mass, 1 mmol arginine/kg lean body mass + 25 g glucose, 25 g glucose alone, and water only, in random order on separate occasions, at 0800. Blood samples were obtained at baseline and at 10-min intervals over the next 2 h and were assayed for glucose, insulin, glucagon, and amino acid concentrations. The half-time for gastric emptying was determined by scintigraphy. Unlike with intravenous administration, ingested arginine did not stimulate a rise in insulin concentration. The glucagon concentration was increased. Arginine attenuated and prolonged the glucose rise when it was ingested with glucose. Gastric emptying time was similar after ingestion of glucose alone or arginine plus glucose. Arginine, in an amount likely to be ingested in a high-protein meal, does not stimulate insulin secretion but attenuates the increase in glucose when given with glucose. JF - The American journal of clinical nutrition AU - Gannon, Mary C AU - Nuttall, Jennifer A AU - Nuttall, Frank Q AD - Metabolic Research Laboratory and the Section of Endocrinology, Metabolism, and Nutrition, Minneapolis Veterans Administration Medical Center, Department of Food Science and Nutrition, University of Minnesota, Minneapolis 55417, USA. ganno004@tc.umn.edu Y1 - 2002/11// PY - 2002 DA - November 2002 SP - 1016 EP - 1022 VL - 76 IS - 5 SN - 0002-9165, 0002-9165 KW - Blood Glucose KW - 0 KW - Insulin KW - Glucagon KW - 9007-92-5 KW - Arginine KW - 94ZLA3W45F KW - Glucose KW - IY9XDZ35W2 KW - Abridged Index Medicus KW - Index Medicus KW - Administration, Oral KW - Osmolar Concentration KW - Reference Values KW - Drug Interactions KW - Random Allocation KW - Humans KW - Gastric Emptying -- drug effects KW - Glucose -- pharmacology KW - Adult KW - Middle Aged KW - Glucagon -- blood KW - Time Factors KW - Female KW - Glucose -- administration & dosage KW - Male KW - Insulin -- blood KW - Blood Glucose -- analysis KW - Arginine -- pharmacology KW - Arginine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72628141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Oral+arginine+does+not+stimulate+an+increase+in+insulin+concentration+but+delays+glucose+disposal.&rft.au=Gannon%2C+Mary+C%3BNuttall%2C+Jennifer+A%3BNuttall%2C+Frank+Q&rft.aulast=Gannon&rft.aufirst=Mary&rft.date=2002-11-01&rft.volume=76&rft.issue=5&rft.spage=1016&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-11-27 N1 - Date created - 2002-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of comorbid diagnoses on sleep disturbance in PTSD. AN - 72536726; 12393315 AB - Patients with post-traumatic stress disorder (PTSD) are frequently diagnosed with other psychiatric comorbid conditions. This study tested the hypothesis that PTSD patients suffer a greater proportion of sleep problems according to comorbid diagnoses. National Comorbidity Survey (NCS) data from 591 individuals diagnosed with PTSD were analyzed. Revised versions of the Diagnostic Interview Schedule and Composite International Diagnostic Interview were administered to a representative sample of males and females. Groups consisted of patients diagnosed with lifetime PTSD and with current comorbid panic disorder, major depressive disorder, generalized anxiety disorder, and alcohol dependence. Patients diagnosed with PTSD/panic disorder reported a significantly greater proportion of nightmare complaints (96%) and insomnia (100%) compared with the other comorbid groups. A greater proportion of PTSD patients with comorbid panic disorder complain of sleep-related problems than other comorbid groups. This effect appears unique to panic, rather than other general anxiety disorder or depression. Prospective sleep studies are needed to differentiate the role of sleep in PTSD and PD, as well as to examine the role of psychiatric comorbidity in worsening sleep in PTSD patients. Copyright 2002 Elsevier Science Ltd. JF - Journal of psychiatric research AU - Leskin, Gregory A AU - Woodward, Steven H AU - Young, Helena E AU - Sheikh, Javaid I AD - VA Palo Alto Health Care System (116A-MP), 795 Willow Road, Menlo Park, CA 94025, USA. gregory.leskin@med.va.gov PY - 2002 SP - 449 EP - 452 VL - 36 IS - 6 SN - 0022-3956, 0022-3956 KW - Index Medicus KW - Humans KW - Adult KW - Male KW - Female KW - Comorbidity KW - Stress Disorders, Post-Traumatic -- epidemiology KW - Sleep Wake Disorders -- diagnosis KW - Panic Disorder -- epidemiology KW - Stress Disorders, Post-Traumatic -- diagnosis KW - Anxiety Disorders -- epidemiology KW - Substance-Related Disorders -- epidemiology KW - Sleep Wake Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72536726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychiatric+research&rft.atitle=Effects+of+comorbid+diagnoses+on+sleep+disturbance+in+PTSD.&rft.au=Leskin%2C+Gregory+A%3BWoodward%2C+Steven+H%3BYoung%2C+Helena+E%3BSheikh%2C+Javaid+I&rft.aulast=Leskin&rft.aufirst=Gregory&rft.date=2002-11-01&rft.volume=36&rft.issue=6&rft.spage=449&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychiatric+research&rft.issn=00223956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-21 N1 - Date created - 2002-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - New onset migraine associated with use of soy isoflavone supplements. AN - 72192556; 12391374 JF - Neurology AU - Engel, Peter A AD - Department of Medicine, Division of Geriatrics, Albany Medical College and the V.A. Medical Center, Albany, NY, USA. Peter.Engel@med.va.gov Y1 - 2002/10/22/ PY - 2002 DA - 2002 Oct 22 SP - 1289 EP - 1290 VL - 59 IS - 8 SN - 0028-3878, 0028-3878 KW - Isoflavones KW - 0 KW - Soybean Proteins KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Middle Aged KW - Male KW - Soybean Proteins -- adverse effects KW - Isoflavones -- adverse effects KW - Soybeans -- adverse effects KW - Migraine with Aura -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72192556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=New+onset+migraine+associated+with+use+of+soy+isoflavone+supplements.&rft.au=Engel%2C+Peter+A&rft.aulast=Engel&rft.aufirst=Peter&rft.date=2002-10-22&rft.volume=59&rft.issue=8&rft.spage=1289&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-11-14 N1 - Date created - 2002-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ruthenium red-sensitive cation channels, but not calcitonin gene-related peptide or substance P-mediated mechanisms, protect duodenal villi against acid-induced damage. AN - 72133530; 12354580 AB - Intestinal mucosal capsaicin-sensitive afferent nerves mediate, in part, the protective mesenteric hyperemia after intraduodenal acidification. Mechanisms associated the sensory neuropeptides, e.g. calcitonin gene-related peptide (CGRP), substance P, and ruthenium red-sensitive cation channels contribute to acid-induced mesenteric hyperemia, but whether they play a role in protection against acid-induced duodenal villous damage is not known. We tested the hypothesis that in doses that attenuate acid-induced hyperemia, inhibitors of these mechanisms will exacerbate acid-induced duodenal villous damage. Intravenous vehicle, specific receptor antagonists of CGRP (CGRP(8-37)), substance P (CP 96345), intraduodenal ruthenium red or vehicle was administered, followed by intraduodenal perfusion with 0.1 N HCl. Duodenal tissue was processed for hematoxylin and eosin staining. Villous damage was scored by blinded observers. Deep villous injury was significantly increased after treatment with ruthenium red, but not with CGRP(8-37) or CP 96345. These findings support the hypothesis that ruthenium red-sensitive cation channels, but not neuropeptides associated with intestinal mucosal afferent nerves, are involved in the acid-sensing mechanism which mediates the protection against acid-induced duodenal villous damage. JF - Life sciences AU - Leung, Felix W AU - Iwata, Fumihiro AU - Kao, John AU - Seno, Kyoji AU - Itoh, Makoto AU - Leung, Joseph W C AD - Research and Medical Services, Sepulveda Ambulatory Care Center and Nursing Home, Greater Los Angeles Healthcare System, California 91343, USA. felix.leung@med.va.gov Y1 - 2002/10/18/ PY - 2002 DA - 2002 Oct 18 SP - 2617 EP - 2624 VL - 71 IS - 22 SN - 0024-3205, 0024-3205 KW - Acids KW - 0 KW - Biphenyl Compounds KW - Cations KW - Ion Channels KW - Peptide Fragments KW - Ruthenium Red KW - 11103-72-3 KW - calcitonin gene-related peptide (8-37) KW - 119911-68-1 KW - Substance P KW - 33507-63-0 KW - Calcitonin Gene-Related Peptide KW - 83652-28-2 KW - Hydrochloric Acid KW - QTT17582CB KW - Capsaicin KW - S07O44R1ZM KW - CP 96345 KW - W22ILA2I52 KW - Index Medicus KW - Rats KW - Acids -- toxicity KW - Animals KW - Rats, Sprague-Dawley KW - Hydrochloric Acid -- toxicity KW - Dose-Response Relationship, Drug KW - Hydrogen-Ion Concentration KW - Peptide Fragments -- pharmacology KW - Neurons, Afferent -- drug effects KW - Biphenyl Compounds -- pharmacology KW - Male KW - Cations -- metabolism KW - Capsaicin -- pharmacology KW - Duodenum -- innervation KW - Intestinal Mucosa -- innervation KW - Ion Channels -- drug effects KW - Substance P -- antagonists & inhibitors KW - Ion Channels -- physiology KW - Substance P -- physiology KW - Duodenum -- drug effects KW - Calcitonin Gene-Related Peptide -- pharmacology KW - Intestinal Mucosa -- drug effects KW - Intestinal Mucosa -- pathology KW - Calcitonin Gene-Related Peptide -- physiology KW - Ruthenium Red -- pharmacology KW - Duodenum -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72133530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Ruthenium+red-sensitive+cation+channels%2C+but+not+calcitonin+gene-related+peptide+or+substance+P-mediated+mechanisms%2C+protect+duodenal+villi+against+acid-induced+damage.&rft.au=Leung%2C+Felix+W%3BIwata%2C+Fumihiro%3BKao%2C+John%3BSeno%2C+Kyoji%3BItoh%2C+Makoto%3BLeung%2C+Joseph+W+C&rft.aulast=Leung&rft.aufirst=Felix&rft.date=2002-10-18&rft.volume=71&rft.issue=22&rft.spage=2617&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-12-03 N1 - Date created - 2002-09-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cavernous hemangioma of the external ear canal. AN - 85369930; pmid-12368608 AB - To document the occurrence of a cavernous hemangioma of the external ear canal and to review the relevant literature. STUDY DESIGN Case report and literature review.Review of a patient chart, imaging studies, operative report, and histologic findings.A cavernous hemangioma of the external ear canal not involving the tympanic membrane was surgically excised without complication. This is the third documented cavernous hemangioma of the external ear canal without tympanic membrane involvement in the English literature. Computed tomography scan is invaluable to narrow the differential diagnosis. Complete removal is curative.Cavernous hemangioma of the external ear canal with or without tympanic membrane involvement is a rare otologic entity amenable to surgical treatment. Temporal bone computed tomography scan imaging is an important preoperative diagnostic tool. JF - The Laryngoscope AU - Reeck, Jay B AU - Yen, Thomas L AU - Szmit, Andrew AU - Cheung, Steven W AD - Division of Otology, Neurotology and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, Veterans Administration Medical Center, San Francisco, California, USA. Y1 - 2002/10// PY - 2002 DA - Oct 2002 SP - 1750 EP - 1752 VL - 112 IS - 10 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - *Ear Canal KW - *Ear Neoplasms: diagnosis KW - Ear Neoplasms: surgery KW - *Hemangioma, Cavernous: diagnosis KW - Hemangioma, Cavernous: surgery KW - Humans KW - Male KW - Middle Aged KW - Tomography, X-Ray Computed UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85369930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Cavernous+hemangioma+of+the+external+ear+canal.&rft.au=Reeck%2C+Jay+B%3BYen%2C+Thomas+L%3BSzmit%2C+Andrew%3BCheung%2C+Steven+W&rft.aulast=Reeck&rft.aufirst=Jay&rft.date=2002-10-01&rft.volume=112&rft.issue=10&rft.spage=1750&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Short course of omeprazole: a better first diagnostic approach to noncardiac chest pain than endoscopy, manometry, or 24-hour esophageal pH monitoring. AN - 85357936; pmid-12352293 AB - Noncardiac chest pain (NCCP) presents as a frequent diagnostic challenge, with patients tending to use a disproportionate level of health care resources. Gastroesophageal reflux disease (GERD) is the most frequent cause of NCCP.To test the efficacy of a potent acid-suppressing agent as a diagnostic test in the evaluation of NCCP and to compare it with three commonly used tests.Eighteen men and 24 women, aged 22 to 77 years, who presented with recurrent chest pain complaints of a noncardiac etiology, as determined by rest/stress perfusion imaging with technetium Tc99m sestamibi (MIBI), were enrolled in a prospective, double-blinded, placebo-controlled, crossover trial using high-dose omeprazole. Thirty-seven patients completed both arms of the trial. Findings were compared with those of endoscopy, manometry, and ambulatory 24-hour two-channel esophageal pH monitoring. All patients underwent initial diagnostic upper endoscopy, esophageal manometry, and 24-hour pH monitoring. Patients were then randomly assigned to either placebo or omeprazole (40 mg/d orally twice daily) for 14 days, washed out for 21 days, and then crossed over. Patient's symptoms were determined using a Visual Analogue Scale to measure the severity of chest pain before and after each period.Seventy-one percent of patients in the omeprazole arm reported improved chest pain, whereas only 18% in the placebo arm did. Abnormal results on manometry (20%), 24-hour pH monitoring (42%), or endoscopy with visual evidence of esophagitis (26%) were found less frequently. Combination of the three tests did not significantly increase their usefulness. In NCCP patients with GERD, as defined by positive results on a 24-hour pH test or presence of esophagitis on endoscopy, omeprazole treatment led to a response in 95% of patients, whereas 90% of GERD-positive patients treated with placebo did not respond. Of NCCP patients determined to be GERD negative, 39% responded to omeprazole.Omeprazole as a first diagnostic tool in the evaluation of MIBI-negative NCCP is sensitive and specific for determining the cause of NCCP. Endoscopy, manometry, and 24-hour pH monitoring were not only less sensitive in diagnosing NCCP, but they were significantly more expensive. JF - Journal of clinical gastroenterology AU - Pandak, William M AU - Arezo, Shahwali AU - Everett, Sharon AU - Jesse, Robert AU - DeCosta, Gail AU - Crofts, Theresa AU - Gennings, Chris AU - Siuta, Michael AU - Zfass, Alvin AD - Division of Gastroenterology and Department of Biostatistics, Virginia Commonweath University, Richmond, Virginia 23249, USA. cecile.rock@med.va.gov Y1 - 2002/10// PY - 2002 DA - Oct 2002 SP - 307 EP - 314 VL - 35 IS - 4 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Anti-Ulcer Agents: administration & dosage KW - *Anti-Ulcer Agents: diagnostic use KW - *Chest Pain: diagnosis KW - *Chest Pain: physiopathology KW - Cross-Over Studies KW - Diagnosis, Differential KW - Dose-Response Relationship, Drug KW - Double-Blind Method KW - *Esophagoscopy KW - Female KW - *Gastroesophageal Reflux: diagnosis KW - *Gastroesophageal Reflux: physiopathology KW - Humans KW - *Hydrogen-Ion Concentration KW - Male KW - *Manometry KW - Middle Aged KW - Omeprazole: administration & dosage KW - *Omeprazole: diagnostic use KW - Pain Measurement KW - Prospective Studies KW - Sensitivity and Specificity KW - Time Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85357936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Short+course+of+omeprazole%3A+a+better+first+diagnostic+approach+to+noncardiac+chest+pain+than+endoscopy%2C+manometry%2C+or+24-hour+esophageal+pH+monitoring.&rft.au=Pandak%2C+William+M%3BArezo%2C+Shahwali%3BEverett%2C+Sharon%3BJesse%2C+Robert%3BDeCosta%2C+Gail%3BCrofts%2C+Theresa%3BGennings%2C+Chris%3BSiuta%2C+Michael%3BZfass%2C+Alvin&rft.aulast=Pandak&rft.aufirst=William&rft.date=2002-10-01&rft.volume=35&rft.issue=4&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: J Clin Gastroenterol. 2002 Oct;35(4):292-4[12352290] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Social class and mortality in older women. AN - 85281345; pmid-12464370 AB - In middle-aged people, social class is one of the strongest predictors of mortality. However, to date, research prospectively evaluating the relationship between social class and mortality in the older persons has produced conflicting results. This may be due to the lack of clinical covariates in many analyses. The objective of this study was to determine the relationship between social class markers-education, income, husband's work history, and personal work history-and mortality in a cohort of older women, after adjusting for clinical and behavioral factors. The participants were 737 ambulatory, community-living women, age 72 and older, followed from 1989 to 1993. In addition to education attained, present income, husband's work history, and personal work history, proportional hazard models adjusted for age, race, marital status, number of chronic conditions, number of medications used, Activities of Daily Living status, Mini-Mental State Exam score, physical activity, and alcohol use. In multivariable models personal work history was the only social class marker that remained significantly associated with mortality. Compared with managers and professionals, women who never worked outside the home had a 3.5 greater risk of death (95% CI, 1.6-7.5), while women who had worked in partly/unskilled or skilled professions were over two and a half times more likely to die; the adjusted hazard ratios were 2.7 (95% CI, 1.2-6.4) and 2.7 (95% CI, 1.3-5.7), respectively. In this population of older women, personal work history was the only social class marker predictive of mortality. JF - Journal of Clinical Epidemiology AU - Long, Judith A AU - Ickovics, Jeannette R AU - Gill, Thomas M AU - Horwitz, Ralph I AD - Philadelphia Veterans Administration, Center for Health Equity Research and Promotion, 1201 Blockley Hall, 423 Guardian Drive. 19104-6021, Philadelphia, PA, USA PY - 2002 SP - 952 EP - 958 VL - 55 IS - 10 SN - 0895-4356, 0895-4356 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85281345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Epidemiology&rft.atitle=Social+class+and+mortality+in+older+women.&rft.au=Long%2C+Judith+A%3BIckovics%2C+Jeannette+R%3BGill%2C+Thomas+M%3BHorwitz%2C+Ralph+I&rft.aulast=Long&rft.aufirst=Judith&rft.date=2002-10-01&rft.volume=55&rft.issue=10&rft.spage=952&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Epidemiology&rft.issn=08954356&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Tenofovir disoproxil fumarate: a nucleotide reverse transcriptase inhibitor for the treatment of HIV infection. AN - 72728877; 12462284 AB - Tenofovir disoproxil fumarate (DF) is the first nucleotide reverse transcriptase inhibitor approved for use in combination with other antiretroviral agents in the treatment of HIV-1 infection in the United States. Unlike the nucleoside reverse transcriptase inhibitors, which must undergo 3 intracellular phosphorylation steps for activation. nucleotide analogues such as tenofovir require only 2 such steps. This reduction in the phosphorylation requirement has the potential to produce more rapid and complete conversion of the drug to its pharmacologically active metabolite. This article describes the pharmacologic properties and potential clinical usefulness of tenofovir DF. Relevant information was identified through searches of MEDLINE (1996-April 2002), Iowa Drug Information Service (1996-April 2002), and International Pharmaceutical Abstracts (1970-April 2002), as well as from meeting abstracts of major HIV/AIDS conferences (1996-2002), using the search terms tenofovir tenofovir disoproxil fumarate, PMPA, bis(POC)PMPA, GS-4331-05, acyclic nucleoside phosphonate, and nucleotide reverse transcriptase inhibitor. Additional information was obtained from material submitted to the US Food and Drug Administration by the manufacturer of tenofovir DF in support of its New Drug Application. In vitro, tenofovir DF has exhibited anti-HIV activity in various HIV-infected cell lines and has produced a synergistic or additive effect against HIV when combined with other antiretroviral agents. In adult humans, tenofovir has a volume of distribution of 0.813 L/kg, is minimally bound to plasma protein (7.2%), has a plasma elimination half-life of 12.0 to 14.4 hours, and is mainly excreted unchanged in urine (70%-80%). Dose adjustment based on sex or body weight does not appear to be necessary, although dose reduction may be necessary in the elderly; there are currently no data on tenofovir DF in renal or hepatic insufficiency. The results of clinical trials suggest the efficacy of tenofovir DF in reducing plasma levels of HIV-1 RNA when used as an add-on to a stable antiretroviral regimen. The most commonly (>3%) reported adverse events in clinical trials have included nausea, diarrhea, asthenia, headache, vomiting, flatulence, abdominal pain, and anorexia. The most commonly (>2%) reported laboratory abnormalities (grade III or IV) included increases in creatine kinase, triglycerides, amylase, aspartate aminotransferase, and alanine aminotransferase, as well as hyperglycemia and glucosuria. Serious adverse events leading to discontinuation of tenofovir DF were infrequent (5%), occurring with an incidence similar to that with placebo (8%). The recommended dosage of tenofovir DF in adults is 300 mg/d PO; pharmacokinetic and efficacy studies in children are ongoing. Although additional studies are needed, tenofovir DF appears to be a promising agent for the treatment of HIV infection. JF - Clinical therapeutics AU - Fung, Horatio B AU - Stone, Elizabeth A AU - Piacenti, Frank J AD - Critical Care Center, Veterans Affairs Medical Center, Bronx, New York 10468, USA. horatio.fung@med.va.gov Y1 - 2002/10// PY - 2002 DA - October 2002 SP - 1515 EP - 1548 VL - 24 IS - 10 SN - 0149-2918, 0149-2918 KW - Anti-HIV Agents KW - 0 KW - Organophosphonates KW - Organophosphorus Compounds KW - Reverse Transcriptase Inhibitors KW - Tenofovir KW - 99YXE507IL KW - Adenine KW - JAC85A2161 KW - Index Medicus KW - Drug Therapy, Combination KW - Animals KW - Hepatitis B -- complications KW - Drug Resistance, Viral KW - Dose-Response Relationship, Drug KW - Humans KW - Clinical Trials as Topic KW - Drug Synergism KW - Hepatitis B -- drug therapy KW - HIV-1 -- drug effects KW - Organophosphorus Compounds -- therapeutic use KW - Reverse Transcriptase Inhibitors -- pharmacology KW - Anti-HIV Agents -- adverse effects KW - Organophosphorus Compounds -- adverse effects KW - Adenine -- adverse effects KW - Reverse Transcriptase Inhibitors -- adverse effects KW - Adenine -- therapeutic use KW - Reverse Transcriptase Inhibitors -- pharmacokinetics KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- complications KW - Anti-HIV Agents -- pharmacology KW - HIV Infections -- drug therapy KW - Organophosphorus Compounds -- pharmacology KW - Reverse Transcriptase Inhibitors -- therapeutic use KW - Adenine -- analogs & derivatives KW - Adenine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72728877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+therapeutics&rft.atitle=Tenofovir+disoproxil+fumarate%3A+a+nucleotide+reverse+transcriptase+inhibitor+for+the+treatment+of+HIV+infection.&rft.au=Fung%2C+Horatio+B%3BStone%2C+Elizabeth+A%3BPiacenti%2C+Frank+J&rft.aulast=Fung&rft.aufirst=Horatio&rft.date=2002-10-01&rft.volume=24&rft.issue=10&rft.spage=1515&rft.isbn=&rft.btitle=&rft.title=Clinical+therapeutics&rft.issn=01492918&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-08 N1 - Date created - 2002-12-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Topographic quantitative EEG response to acute caffeine withdrawal: a comprehensive analysis of multiple quantitative variables. AN - 72726237; 12449850 AB - Most previous studies of the neurophysiological effects of caffeine have focused on the effects of caffeine ingestion, and few studies have examined the effects of caffeine withdrawal. This open study evaluated the quantitative EEG (QEEG) changes occurring during a 4-day period of abstinence in subjects who habitually consume 300 mg or more of caffeine daily. Thirteen subjects underwent QEEG studies during their usual caffeine consumption (baseline) and on days 1, 2, and 4 of a 4-day period of caffeine abstinence. Ten of the subjects underwent a second QEEG on day 4 that consisted of a period of recording after reinstitution of caffeine. A comprehensive analysis of multiple quantitative variables was performed for each study during the abstinence period and compared to the variables obtained at baseline for each subject. Changes occurring during caffeine abstinence included: 1) increases in theta absolute power over all cortical areas, 2) increases in delta absolute power over the frontal cortex, 3) decreases in the mean frequency of both the alpha and beta rhythm, 4) increase in theta relative power and decrease in beta relative power, and 5) significant changes in interhemispheric coherence. Most of these changes tended to return to pre-abstinence baseline levels rapidly after resumption of caffeine consumption. The caffeine withdrawal state affects a number of neurophysiological variables. Further investigation of the neurophysiological aspects of caffeine withdrawal using placebo controlled double blind assessment methods is warranted. JF - Clinical EEG (electroencephalography) AU - Reeves, Roy R AU - Struve, Frederick A AU - Patrick, Gloria AD - G.V. (Sonny) Montgomery VA Medical Center, 1500 E. Woodrow Wilson Drive, Jackson, MS 39216, USA. roy.reeves@med.va.gov Y1 - 2002/10// PY - 2002 DA - October 2002 SP - 178 EP - 188 VL - 33 IS - 4 SN - 0009-9155, 0009-9155 KW - Caffeine KW - 3G6A5W338E KW - Index Medicus KW - Severity of Illness Index KW - Sensitivity and Specificity KW - Analysis of Variance KW - Humans KW - Delta Rhythm -- statistics & numerical data KW - Alpha Rhythm KW - Delta Rhythm -- drug effects KW - Single-Blind Method KW - Beta Rhythm -- drug effects KW - Theta Rhythm -- statistics & numerical data KW - Adult KW - Middle Aged KW - Statistics as Topic KW - Adolescent KW - Theta Rhythm -- drug effects KW - Beta Rhythm -- statistics & numerical data KW - Female KW - Male KW - Caffeine -- blood KW - Electroencephalography -- statistics & numerical data KW - Cerebral Cortex -- drug effects KW - Brain Mapping KW - Substance Withdrawal Syndrome -- physiopathology KW - Caffeine -- administration & dosage KW - Caffeine -- adverse effects KW - Electroencephalography -- drug effects KW - Caffeine -- urine KW - Cerebral Cortex -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72726237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+EEG+%28electroencephalography%29&rft.atitle=Topographic+quantitative+EEG+response+to+acute+caffeine+withdrawal%3A+a+comprehensive+analysis+of+multiple+quantitative+variables.&rft.au=Reeves%2C+Roy+R%3BStruve%2C+Frederick+A%3BPatrick%2C+Gloria&rft.aulast=Reeves&rft.aufirst=Roy&rft.date=2002-10-01&rft.volume=33&rft.issue=4&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Clinical+EEG+%28electroencephalography%29&rft.issn=00099155&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-21 N1 - Date created - 2002-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Scarred atrophic thyroid after I-131 therapy for Graves' disease documented at autopsy. AN - 72642016; 12408698 AB - Radioiodine is used as the definitive treatment of choice in most patients with Graves' hyperthyroidism. Most patients with Graves' disease eventually develop hypothyroidism following I-131 therapy and require thyroid hormone replacement therapy. We present a patient with aortic stenotic cardiac disease and coronary artery disease who suffered from fatigue, weight loss and atrial fibrillation. The patient's radionuclide study, as well as the T4 and TSH, confirmed Graves' disease and he received I-131 therapy. Our patient's development of hypothyroidism following 5 mCi I-131 therapy after seven days later was considered as unusual; in addition, our patient, at autopsy, had documented histopathologic changes confirming atrophy and fibrosis of the thyroid gland. JF - Journal of the National Medical Association AU - Shih, Wei-Jen AU - Mitchell, Bonnie AU - Schott, Jennifer C AD - Nuclear Medicine Service, Lexington VA Medical Center, Kentucky 40511, USA. wei-jen.shih@med.va.gov Y1 - 2002/10// PY - 2002 DA - October 2002 SP - 915 EP - 919 VL - 94 IS - 10 SN - 1943-4693, 1943-4693 KW - Iodine Radioisotopes KW - 0 KW - Index Medicus KW - Fatal Outcome KW - Fibrosis KW - Humans KW - Aged KW - Atrophy KW - Male KW - Iodine Radioisotopes -- therapeutic use KW - Graves Disease -- radiotherapy KW - Thyroid Gland -- pathology KW - Iodine Radioisotopes -- adverse effects KW - Hypothyroidism -- chemically induced KW - Thyroid Gland -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72642016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Medical+Association&rft.atitle=Scarred+atrophic+thyroid+after+I-131+therapy+for+Graves%27+disease+documented+at+autopsy.&rft.au=Shih%2C+Wei-Jen%3BMitchell%2C+Bonnie%3BSchott%2C+Jennifer+C&rft.aulast=Shih&rft.aufirst=Wei-Jen&rft.date=2002-10-01&rft.volume=94&rft.issue=10&rft.spage=915&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Medical+Association&rft.issn=19434693&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-10 N1 - Date created - 2002-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Scott Med J. 1978 Oct;23(4):263-5 [82999] N Engl J Med. 1984 Aug 16;311(7):426-32 [6205272] Br Med J (Clin Res Ed). 1984 Aug 11;289(6441):361-3 [6432100] Lancet. 1974 Apr 20;1(7860):704-5 [4132423] Eur J Clin Invest. 1996 Jan;26(1):59-63 [8682157] J Nucl Med. 1991 Mar;32(3):411-6 [2005449] Arch Intern Med. 1975 May;135(5):673-5 [1053273] Lancet. 1975 Dec 20;2(7947):1231-3 [53722] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Late-life depression: psychopathology, medical interventions, and dental implications. AN - 72164680; 12374911 AB - Late-life depression (LLD) initially occurs after age 65 years and is a major public health concern because the elderly who are at high risk constitute an ever-expanding segment of the population. LLD is a mental illness in which mood, thought content, and behavioral patterns are impaired, causing the individual distress, compromising social function, and impairing self-maintenance skills (eg, bathing, dressing, hygiene). LLD characterized by marked sadness or a loss of interest or pleasure in daily activities and may be accompanied by weight change, sleep disturbance, fatigue, difficulty in concentration, and a high suicide rate. Diagnosis of LLD is sometimes complicated by a denial of mood change and an inability to distinguish symptoms of a concurrent physical illness from those of a depressive etiology. The disorder is most frequently treated with antidepressant medications, and although older individuals have a recovery rate that is comparable with younger adults, they often take longer to recover, have more frequent relapses, and are more sensitive to the side effects of the drugs. Individuals undergoing treatment for LLD and those whose illness has not been diagnosed or treated often are seen with significant oral disease by the dentist. Dentists need to be cognizant of how to safely and compassionately provide care to those already receiving mental health services. They must also be familiar with the psychiatric symptoms of the disorder to effectuate a timely referral to a physician of those with occult or relapsing disease. LLD is frequently associated with a disinterest in oral hygiene, a cariogenic diet, diminished salivary flow, rampant dental decay, advanced periodontal disease, and oral dysesthesias. Many medications used to treat the disease magnify the xerostomia and increase the incidence of dental disease. Appropriate dental management necessitates a vigorous preventive dental education program, the use of artificial salivary products, antiseptic mouthwash, daily fluoride mouth rinse, and special precautions in administration of local anesthetics with vasoconstrictors and prescription of analgesics. Dentists who invoke appropriate precautions can usually provide a full range of services to individuals with LLD, thereby enhancing patient self-esteem and contributing to the psychotherapeutic aspect of management. JF - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics AU - Friedlander, Arthur H AU - Norman, Dean C AD - Veterans Affairs Greater Los Angeles Healthcare System, CA 90073, USA. arthur.friedlander@med.va.gov Y1 - 2002/10// PY - 2002 DA - October 2002 SP - 404 EP - 412 VL - 94 IS - 4 SN - 1079-2104, 1079-2104 KW - Antidepressive Agents KW - 0 KW - Dentistry KW - Index Medicus KW - Sensation Disorders -- prevention & control KW - Thinking KW - Dental Caries -- prevention & control KW - Humans KW - Social Behavior KW - Periodontal Diseases -- etiology KW - Activities of Daily Living KW - Aged KW - Xerostomia -- therapy KW - Antidepressive Agents -- adverse effects KW - Xerostomia -- etiology KW - Dental Caries -- etiology KW - Patient Education as Topic KW - Periodontal Diseases -- prevention & control KW - Oral Hygiene KW - Sensation Disorders -- etiology KW - Antidepressive Agents -- therapeutic use KW - Affect KW - Diet, Cariogenic KW - Stress, Psychological -- psychology KW - Depression -- physiopathology KW - Depression -- psychology KW - Depression -- drug therapy KW - Mouth Diseases -- etiology KW - Tooth Diseases -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72164680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oral+surgery%2C+oral+medicine%2C+oral+pathology%2C+oral+radiology%2C+and+endodontics&rft.atitle=Late-life+depression%3A+psychopathology%2C+medical+interventions%2C+and+dental+implications.&rft.au=Friedlander%2C+Arthur+H%3BNorman%2C+Dean+C&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2002-10-01&rft.volume=94&rft.issue=4&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Oral+surgery%2C+oral+medicine%2C+oral+pathology%2C+oral+radiology%2C+and+endodontics&rft.issn=10792104&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-09 N1 - Date created - 2002-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. AN - 72147609; 12364355 AB - Hypertension caused by angiotensin II is dependent on vascular superoxide (O2*-) production. The nicotinamide adenine dinucleotide phosphate (NAD[P]H) oxidase is a major source of vascular O2*- and is activated by angiotensin II in vitro. However, its role in angiotensin II-induced hypertension in vivo is less clear. In the present studies, we used mice deficient in p47(phox), a cytosolic subunit of the NADPH oxidase, to study the role of this enzyme system in vivo. In vivo, angiotensin II infusion (0.7 mg/kg per day for 7 days) increased systolic blood pressure from 105+/-2 to 151+/-6 mm Hg and increased vascular O2*- formation 2- to 3-fold in wild-type (WT) mice. In contrast, in p47(phox-/-) mice the hypertensive response to angiotensin II infusion (122+/-4 mm Hg; P<0.05) was markedly blunted, and there was no increase of vascular O2*- production. In situ staining for O2*- using dihydroethidium revealed a marked increase of O2*-production in both endothelial and vascular smooth muscle cells of angiotensin II-treated WT mice, but not in those of p47(phox-/-) mice. To directly examine the role of the NAD(P)H oxidase in endothelial production of O2*-, endothelial cells from WT and p47(phox-/-) mice were cultured. Western blotting confirmed the absence of p47(phox) in p47(phox-/-) mice. Angiotensin II increased O2*- production in endothelial cells from WT mice, but not in those from p47(phox-/-) mice, as determined by electron spin resonance spectroscopy. These results suggest a pivotal role of the NAD(P)H oxidase and its subunit p47(phox) in the vascular oxidant stress and the blood pressure response to angiotensin II in vivo. JF - Hypertension (Dallas, Tex. : 1979) AU - Landmesser, Ulf AU - Cai, Hua AU - Dikalov, Sergey AU - McCann, Louise AU - Hwang, Jinah AU - Jo, Hanjoong AU - Holland, Steven M AU - Harrison, David G AD - Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, Atlanta, Ga 30322, USA. Y1 - 2002/10// PY - 2002 DA - October 2002 SP - 511 EP - 515 VL - 40 IS - 4 KW - Phosphoproteins KW - 0 KW - Receptor, Angiotensin, Type 1 KW - Receptors, Angiotensin KW - Superoxides KW - 11062-77-4 KW - Angiotensin II KW - 11128-99-7 KW - NADPH Oxidase KW - EC 1.6.3.1 KW - neutrophil cytosolic factor 1 KW - Index Medicus KW - Space life sciences KW - Non-programmatic KW - Aorta -- metabolism KW - Animals KW - Superoxides -- metabolism KW - Receptors, Angiotensin -- metabolism KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Mice KW - Blood Pressure -- drug effects KW - Male KW - Mice, Knockout KW - Hypertension -- chemically induced KW - Phosphoproteins -- genetics KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- enzymology KW - Endothelium, Vascular -- drug effects KW - Hypertension -- enzymology KW - Phosphoproteins -- physiology KW - Phosphoproteins -- analysis KW - Oxidative Stress KW - Hypertension -- etiology KW - Angiotensin II -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72147609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.atitle=Role+of+p47%28phox%29+in+vascular+oxidative+stress+and+hypertension+caused+by+angiotensin+II.&rft.au=Landmesser%2C+Ulf%3BCai%2C+Hua%3BDikalov%2C+Sergey%3BMcCann%2C+Louise%3BHwang%2C+Jinah%3BJo%2C+Hanjoong%3BHolland%2C+Steven+M%3BHarrison%2C+David+G&rft.aulast=Landmesser&rft.aufirst=Ulf&rft.date=2002-10-01&rft.volume=40&rft.issue=4&rft.spage=511&rft.isbn=&rft.btitle=&rft.title=Hypertension+%28Dallas%2C+Tex.+%3A+1979%29&rft.issn=1524-4563&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-16 N1 - Date created - 2002-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Citalopram-associated SIADH. AN - 72110697; 12243606 AB - To report a case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with use of citalopram in an elderly male patient and to review the English-language literature for any previous reports of SIADH or hyponatremia caused by citalopram. An 87-year-old Filipino man was admitted to the hospital reporting malaise, confusion, dizziness, and falls approximately 3 weeks following an increase in his citalopram dosage from 10 to 20 mg/d. On physical examination, the patient was euvolemic and had no evidence of malignancy, cardiac, renal, or hepatic disease. Pertinent laboratory test results revealed hyponatremia, serum hypoosmolality, urine hyperosmolality, and elevated urine sodium concentration, leading to a diagnosis of SIADH. Citalopram was discontinued and fluid restrictions were instituted. The patient was discharged after his serum sodium increased from 122 to 128 mEq/L and he reported increased strength and decreased confusion. Five days after discharge, the patient denied experiencing any new falls, weakness, confusion, or lethargy. His serum sodium measured that day was 131 mEq/L; 2 months later, it was 135 mEq/L. We report the seventh case of citalopram-induced hyponatremia published in the English language and the second in a man. Review of the cases demonstrated that the onset of citalopram-induced hyponatremia or SIADH ranged from 6 to 20 days. Potential risk factors for SIADH due to citalopram included advanced age, female gender, concomitant use of medications known to cause SIADH or hyponatremia, and, possibly, higher citalopram doses. Elderly patients receiving citalopram should be monitored for signs and symptoms of SIADH, especially in the first few weeks of therapy, in the presence of risk factors, and during dose escalation. JF - The Annals of pharmacotherapy AU - Barclay, Teresa S AU - Lee, Audrey J AD - Pharmacy Department, Veterans Affairs Medical Center, San Francisco, CA 94121, USA. teresa.barclay@med.va.gov Y1 - 2002/10// PY - 2002 DA - October 2002 SP - 1558 EP - 1563 VL - 36 IS - 10 SN - 1060-0280, 1060-0280 KW - Serotonin Uptake Inhibitors KW - 0 KW - Citalopram KW - 0DHU5B8D6V KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Aged KW - Hyponatremia -- chemically induced KW - Male KW - Serotonin Uptake Inhibitors -- administration & dosage KW - Citalopram -- administration & dosage KW - Inappropriate ADH Syndrome -- chemically induced KW - Serotonin Uptake Inhibitors -- adverse effects KW - Citalopram -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72110697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Citalopram-associated+SIADH.&rft.au=Barclay%2C+Teresa+S%3BLee%2C+Audrey+J&rft.aulast=Barclay&rft.aufirst=Teresa&rft.date=2002-10-01&rft.volume=36&rft.issue=10&rft.spage=1558&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-25 N1 - Date created - 2002-09-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene Dosage and Linezolid Resistance in Enterococcus faecium and Enterococcus faecalis AN - 18490351; 5457310 AB - Resistance to linezolid has been associated with a G2576U mutation in domain V of the 23S rRNA. We analyzed nine clinical isolates of linezolid-resistant enterococci and showed a clear association between the number of 23S rRNA genes containing this mutation and the level of linezolid resistance expressed. JF - Antimicrobial Agents & Chemotherapy AU - Marshall, SH AU - Donskey, C J AU - Hutton-Thomas, R AU - Salata, R A AU - Rice, L B AD - Medical Service 111(W), VA Medical Center, 10701 East Blvd., Cleveland, OH 44106, louis.rice@med.va.gov Y1 - 2002/10// PY - 2002 DA - Oct 2002 SP - 3334 EP - 3336 VL - 46 IS - 10 SN - 0066-4804, 0066-4804 KW - Linezolid KW - Microbiology Abstracts B: Bacteriology KW - J 02814:Drug resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18490351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Gene+Dosage+and+Linezolid+Resistance+in+Enterococcus+faecium+and+Enterococcus+faecalis&rft.au=Marshall%2C+SH%3BDonskey%2C+C+J%3BHutton-Thomas%2C+R%3BSalata%2C+R+A%3BRice%2C+L+B&rft.aulast=Marshall&rft.aufirst=SH&rft.date=2002-10-01&rft.volume=46&rft.issue=10&rft.spage=3334&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.46.10.3334-3336.2002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1128/AAC.46.10.3334-3336.2002 ER - TY - JOUR T1 - Self-rated childhood emotional neglect and CSF monoamine indices in abstinent cocaine-abusing adults: possible implications for suicidal behavior. AN - 72177436; 12379452 AB - Non-human primate studies suggest that early environmental influences may have an enduring effect on central serotonin function. Therefore, it was decided to examine in humans whether childhood trauma might be related to cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) as an adult. A total of 29 withdrawn cocaine-dependent patients completed the Childhood Trauma Questionnaire. They also had a lumbar puncture for determination of CSF concentrations of 5-HIAA. CSF concentrations of the dopamine metabolite homovanillic acid (HVA) were also determined. Childhood emotional neglect scores showed significant negative correlations with CSF levels of 5-HIAA and HVA, and patients with emotional neglect scores above the median had significantly lower CSF 5-HIAA and HVA levels than patients with emotional neglect scores at or below the median. These findings suggest the possibility that childhood trauma may have an effect on central monoamine function as an adult. JF - Psychiatry research AU - Roy, Alec AD - Department of Veterans Affairs, New Jersey Healthcare System, 385 Tremont Avenue, East Orange, NJ07018, USA. alec.roy@med.va.gov Y1 - 2002/09/15/ PY - 2002 DA - 2002 Sep 15 SP - 69 EP - 75 VL - 112 IS - 1 SN - 0165-1781, 0165-1781 KW - Serotonin KW - 333DO1RDJY KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Dopamine KW - VTD58H1Z2X KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Risk KW - Reference Values KW - Humans KW - Adult KW - Middle Aged KW - Child KW - Male KW - Homovanillic Acid -- cerebrospinal fluid KW - Cocaine-Related Disorders -- cerebrospinal fluid KW - Child Abuse -- psychology KW - Serotonin -- physiology KW - Suicide, Attempted -- psychology KW - Cocaine-Related Disorders -- psychology KW - Dopamine -- physiology KW - Hydroxyindoleacetic Acid -- cerebrospinal fluid KW - Cocaine-Related Disorders -- rehabilitation KW - Suicide, Attempted -- prevention & control KW - Suicide -- psychology KW - Suicide -- prevention & control KW - Child Abuse -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72177436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Self-rated+childhood+emotional+neglect+and+CSF+monoamine+indices+in+abstinent+cocaine-abusing+adults%3A+possible+implications+for+suicidal+behavior.&rft.au=Roy%2C+Alec&rft.aulast=Roy&rft.aufirst=Alec&rft.date=2002-09-15&rft.volume=112&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-07 N1 - Date created - 2002-10-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chinese hamster ovary cell motility to fibronectin is modulated by the second extracellular loop of CD9. Identification of a putative fibronectin binding site. AN - 72041535; 12068019 AB - CD9, a member of the tetraspanin family of proteins, is characterized by four transmembrane domains and two extracellular loops. Surface expression of CD9 on Chinese hamster ovary (CHO) cells dramatically enhances spreading and motility on fibronectin. To elucidate the mechanistic basis of CD9-fibronectin interaction, binding to fibronectin was investigated using purified and recombinant forms of CD9. The affinity of fibronectin for CD9 in enzyme-linked immunosorbent assay was 81 +/- 25 nm. The binding of fibronectin to immobilized CD9 was enhanced by Ca(2+) ions. Protein binding and peptide competition studies demonstrated that peptide 6 derived from CD9 extracellular loop 2 (amino acids 168-192) contained part of the fibronectin-binding domain. Additionally, enhanced adhesion of CD9-CHO-B2 cells to fibronectin was significantly reduced by peptide 6. CD9-CHO cells had a 5-fold increase in motility to fibronectin as compared with mock-transfected controls, an effect that correlated with CD9 cell surface density. Truncation of CD9 extracellular loop 2 and peptide 6 caused inhibition of CD9-CHO cell motility to fibronectin. Deletion of CD9 extracellular loop 1 had no significant effect on CHO cell motility. These findings demonstrate a critical role for CD9 extracellular loop 2 in cell motility to fibronectin and clarify the mechanism by which CD9-fibronectin interaction modulates cell adhesion and motility. JF - The Journal of biological chemistry AU - Longhurst, Celia M AU - Jacobs, Jonathan D AU - White, Melanie M AU - Crossno, Joseph T AU - Fitzgerald, Deborah A AU - Bao, Jianxong AU - Fitzgerald, Thomas J AU - Raghow, Rajendra AU - Jennings, Lisa K AD - Vascular Biology Center of Excellence and the Department of Pharmacology, University of Tennessee Health Science Center and the Veterans Administration Medical Center, Memphis, Tennessee 38163, USA. Y1 - 2002/09/06/ PY - 2002 DA - 2002 Sep 06 SP - 32445 EP - 32452 VL - 277 IS - 36 SN - 0021-9258, 0021-9258 KW - Antigens, CD KW - 0 KW - Antigens, CD9 KW - DNA, Complementary KW - Fibronectins KW - Membrane Glycoproteins KW - Peptides KW - Recombinant Proteins KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Cell Movement KW - Animals KW - Dose-Response Relationship, Drug KW - Amino Acid Sequence KW - Gene Deletion KW - Binding Sites KW - Phenotype KW - Mutagenesis, Site-Directed KW - Calcium -- metabolism KW - Transfection KW - Recombinant Proteins -- metabolism KW - Cells, Cultured KW - DNA, Complementary -- metabolism KW - Molecular Sequence Data KW - Peptides -- chemistry KW - Enzyme-Linked Immunosorbent Assay KW - CHO Cells KW - Sequence Homology, Amino Acid KW - Protein Structure, Tertiary KW - Cell Adhesion KW - Cricetinae KW - Antigens, CD -- physiology KW - Antigens, CD -- chemistry KW - Antigens, CD -- metabolism KW - Fibronectins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72041535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Chinese+hamster+ovary+cell+motility+to+fibronectin+is+modulated+by+the+second+extracellular+loop+of+CD9.+Identification+of+a+putative+fibronectin+binding+site.&rft.au=Longhurst%2C+Celia+M%3BJacobs%2C+Jonathan+D%3BWhite%2C+Melanie+M%3BCrossno%2C+Joseph+T%3BFitzgerald%2C+Deborah+A%3BBao%2C+Jianxong%3BFitzgerald%2C+Thomas+J%3BRaghow%2C+Rajendra%3BJennings%2C+Lisa+K&rft.aulast=Longhurst&rft.aufirst=Celia&rft.date=2002-09-06&rft.volume=277&rft.issue=36&rft.spage=32445&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-29 N1 - Date created - 2002-09-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Developments in medical oncology and their implications for interventional radiology. AN - 72825190; 12524649 AB - Although surgery and radiation therapy have always been spatially targeted, chemotherapy as administered by oncologists has remained steadfastly committed to non-targeted systemic delivery. Decades of pharmaceutical research have yielded agents appropriate for intravenous use, but countless potentially efficacious agents have been discarded because of pharmacokinetic and toxicity profiles unsuitable for systemic delivery. With the emerging technology of biological agents comes a new series of challenges. These agents tend to be larger, less long-lived, and antigenic when compared with the agents of the past. Meanwhile, interventional radiologists have shown that targeted methods of delivery can have substantial impact on the efficacy and toxicity of agents. Laboratory scientists have developed new bullets; we interventional radiologists have developed new guns. It is time we take advantage of potential synergies. Copyright 2002, Elsevier Science (USA). All rights reserved. JF - Techniques in vascular and interventional radiology AU - Reid, Tony R AU - Sze, Daniel Y AD - Palo Alto Veterans Administration Medical Center and Stanford University Medical Center, Palo Alto, CA 94305-5642, USA. Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 177 EP - 181 VL - 5 IS - 3 SN - 1089-2516, 1089-2516 KW - Antineoplastic Agents KW - 0 KW - ONYX015 KW - Viral Vaccines KW - Index Medicus KW - Transfection -- methods KW - Infusions, Intra-Arterial KW - Antineoplastic Agents -- administration & dosage KW - Colorectal Neoplasms -- pathology KW - Humans KW - Medical Oncology KW - Viral Vaccines -- administration & dosage KW - Liver Neoplasms -- therapy KW - Viral Vaccines -- genetics KW - Genetic Therapy KW - Radiology, Interventional KW - Liver Neoplasms -- secondary KW - Adenoviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72825190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Techniques+in+vascular+and+interventional+radiology&rft.atitle=Developments+in+medical+oncology+and+their+implications+for+interventional+radiology.&rft.au=Reid%2C+Tony+R%3BSze%2C+Daniel+Y&rft.aulast=Reid&rft.aufirst=Tony&rft.date=2002-09-01&rft.volume=5&rft.issue=3&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Techniques+in+vascular+and+interventional+radiology&rft.issn=10892516&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-09 N1 - Date created - 2003-01-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental controls in the management of allergic asthma. AN - 72678042; 12428541 AB - Environmental allergen control is one of the four primary goals of good asthma management. The American Academy of Allergy, Asthma, and Immunology has published a position statement [78] that endorses the National Asthma Education and Prevention Program management guidelines [23] and recommends that every patient with persistent asthma be evaluated for environmental allergen sensitivity. Patients who have sensitivities should receive practical advice on allergen avoidance. An accumulating body of knowledge indicates that such measures, when strictly applied for a sufficient period of time, can indeed reduce asthma symptoms, need for medication, and airway hyperresponsiveness. Ongoing prospective trials in large numbers of patients are being conducted and should enhance the ability to make proper recommendations to patients. JF - The Medical clinics of North America AU - Bush, Robert K AD - Department of Allergy, William S. Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA. robert.bush@med.va.gov Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 973 EP - 989 VL - 86 IS - 5 SN - 0025-7125, 0025-7125 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Hypersensitivity -- complications KW - Asthma -- etiology KW - Asthma -- prevention & control KW - Environmental Exposure -- standards KW - Environmental Exposure -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72678042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Medical+clinics+of+North+America&rft.atitle=Environmental+controls+in+the+management+of+allergic+asthma.&rft.au=Bush%2C+Robert+K&rft.aulast=Bush&rft.aufirst=Robert&rft.date=2002-09-01&rft.volume=86&rft.issue=5&rft.spage=973&rft.isbn=&rft.btitle=&rft.title=The+Medical+clinics+of+North+America&rft.issn=00257125&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-11-26 N1 - Date created - 2002-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Source monitoring in alcoholism. AN - 72674182; 12424654 AB - Recent research on the neural bases of source memory suggests that this type of memory is relevant to the neuropsychological assessment of neurobehavioral disorders. Source memory refers to the ability to discriminate the origin or source of information (e.g., did I think of the idea or did I read about it). We examined source monitoring in abstinent alcoholic patients (N = 53) and nonalcoholic controls (N = 34) and report significant impairments in the alcoholic patients' ability to remember the source of recently presented information. Decrements in source memory were uncorrelated with alcoholic patients' neuropsychological deficits on the Wisconsin Card Sorting Test or the Benton Facial Recognition Test. Using qualitative measures of brain CT scans in a subsample of 39 alcoholic patients, we found that source memory was correlated with Sylvian fissure ratings in the left hemisphere. We propose that source memory decrements are another area of neuropsychological functioning affected in chronic alcoholism. Tasks of source memory may offer the neuropsychologist a valuable new tool for evaluating cognitive functions in neurobehavioral disorders. JF - Journal of clinical and experimental neuropsychology AU - Schwartz, Barbara L AU - Parker, Elizabeth S AU - Deutsch, Stephen I AU - Rosse, Richard B AU - Kaushik, Mohini AU - Isaac, Alexander AD - Psychiatry Service, Veterans Affairs Medical Center, Washington, DC 20422, USA. Barbara.Schwartz@med.va.gov Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 806 EP - 817 VL - 24 IS - 6 SN - 1380-3395, 1380-3395 KW - Index Medicus KW - Humans KW - Brain -- pathology KW - Adult KW - Tomography, X-Ray Computed KW - Sampling Studies KW - Task Performance and Analysis KW - Retention (Psychology) KW - Neuropsychological Tests KW - Male KW - Memory KW - Alcoholism -- pathology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72674182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+and+experimental+neuropsychology&rft.atitle=Source+monitoring+in+alcoholism.&rft.au=Schwartz%2C+Barbara+L%3BParker%2C+Elizabeth+S%3BDeutsch%2C+Stephen+I%3BRosse%2C+Richard+B%3BKaushik%2C+Mohini%3BIsaac%2C+Alexander&rft.aulast=Schwartz&rft.aufirst=Barbara&rft.date=2002-09-01&rft.volume=24&rft.issue=6&rft.spage=806&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+and+experimental+neuropsychology&rft.issn=13803395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-12-31 N1 - Date created - 2002-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bipolar I disorder: psychopathology, medical management and dental implications. AN - 72143623; 12356252 AB - The authors review the clinical features, epidemiology, pathophysiology, medical management, dental findings and dental management of patients who have bipolar I disorder, or BD, previously known as manic-depressive disorder. The authors conducted a MEDLINE search for the period 1995 through 2001 using the key terms "bipolar disorder," "epidemiology," "pathophysiology," "treatment" and "dentistry." The articles they selected for further review included those published in English in peer-reviewed journals; they gave preference to articles reporting randomized, controlled trials. BD is a psychiatric illness characterized by extreme mood swings. Mania is accompanied by euphoria, grandiosity, racing thoughts and lack of insight. Depression is characterized by marked sadness or loss of interest or pleasure in daily activities. The unpredictable mood swings can distress the person, can impair social function and quality of life and are associated with a significant increase in the risk for substance abuse and suicide. BD is common in the United States, with a lifetime prevalence rate of 1.6 percent and recurrence rate of more than 50 percent. The prevalence of dental disease usually is extensive because of poor oral hygiene and medication-induced xerostomia. Preventive dental education, saliva substitutes and anticaries agents are indicated. To avoid adverse drug interactions with the usually prescribed psychiatric medications, special precautions should be taken when administering certain antibiotics, analgesics and sedatives. JF - Journal of the American Dental Association (1939) AU - Friedlander, Arthur H AU - Friedlander, Ida K AU - Marder, Stephen R AD - West Valley/Los Angeles County Department of Health, Van Nuys, Calif, USA. arthur.friedlander@med.va.gov Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 1209 EP - 1217 VL - 133 IS - 9 SN - 0002-8177, 0002-8177 KW - Antidepressive Agents KW - 0 KW - Antimanic Agents KW - Lithium Carbonate KW - 2BMD2GNA4V KW - Dentistry KW - Index Medicus KW - Xerostomia -- etiology KW - Lithium Carbonate -- therapeutic use KW - Dental Caries -- etiology KW - Drug Interactions KW - Humans KW - Antimanic Agents -- adverse effects KW - Periodontal Diseases -- etiology KW - Antimanic Agents -- therapeutic use KW - Antidepressive Agents -- therapeutic use KW - Antidepressive Agents -- adverse effects KW - United States -- epidemiology KW - Bipolar Disorder -- epidemiology KW - Bipolar Disorder -- drug therapy KW - Bipolar Disorder -- psychology KW - Bipolar Disorder -- complications KW - Dental Care for Chronically Ill UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72143623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=Bipolar+I+disorder%3A+psychopathology%2C+medical+management+and+dental+implications.&rft.au=Friedlander%2C+Arthur+H%3BFriedlander%2C+Ida+K%3BMarder%2C+Stephen+R&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2002-09-01&rft.volume=133&rft.issue=9&rft.spage=1209&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-12-10 N1 - Date created - 2002-10-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Am Dent Assoc. 2003 Apr;134(4):420; discussion 420 [12733772] J Am Dent Assoc. 2003 Apr;134(4):420; discussion 420 [12733769] J Am Dent Assoc. 2003 Apr;134(4):420; discussion 420 [12733770] J Am Dent Assoc. 2003 Apr;134(4):420; discussion 420 [12733771] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risperidone decreases craving and relapses in individuals with schizophrenia and cocaine dependence. AN - 72133849; 12355680 AB - To examine the efficacy of atypical neuroleptics for decreasing craving and drug relapses during protracted withdrawal in individuals dually diagnosed with schizophrenia and cocaine dependence. We conducted a 6-week, open-label pilot study comparing risperidone with typical neuroleptics in a sample of withdrawn cocaine-dependent schizophrenia patients. Preliminary results suggest that individuals treated with risperidone had significantly less cue-elicited craving and substance abuse relapses at study completion. Further, they showed a trend toward a greater reduction in negative and global symptoms of schizophrenia. Atypical neuroleptics may help reduce craving and relapses in this population. Future research should include more rigorous double-blind placebo-controlled studies with this class of medications. JF - Canadian journal of psychiatry. Revue canadienne de psychiatrie AU - Smelson, David A AU - Losonczy, Miklos F AU - Davis, Craig W AU - Kaune, Maureen AU - Williams, John AU - Ziedonis, Douglas AD - Department of Veterans Affairs, VISN 3 Mental Illness, Research, Education and Clinical Center, Lyons, New Jersey, USA. david.smelson@med.va.gov Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 671 EP - 675 VL - 47 IS - 7 SN - 0706-7437, 0706-7437 KW - Antipsychotic Agents KW - 0 KW - Risperidone KW - L6UH7ZF8HC KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Motivation KW - Humans KW - Adult KW - Pilot Projects KW - Middle Aged KW - Recurrence KW - Male KW - Female KW - Comorbidity KW - Substance Withdrawal Syndrome -- rehabilitation KW - Antipsychotic Agents -- therapeutic use KW - Cocaine-Related Disorders -- psychology KW - Schizophrenic Psychology KW - Substance Withdrawal Syndrome -- psychology KW - Schizophrenia -- rehabilitation KW - Risperidone -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Risperidone -- therapeutic use KW - Cocaine-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72133849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+journal+of+psychiatry.+Revue+canadienne+de+psychiatrie&rft.atitle=Risperidone+decreases+craving+and+relapses+in+individuals+with+schizophrenia+and+cocaine+dependence.&rft.au=Smelson%2C+David+A%3BLosonczy%2C+Miklos+F%3BDavis%2C+Craig+W%3BKaune%2C+Maureen%3BWilliams%2C+John%3BZiedonis%2C+Douglas&rft.aulast=Smelson&rft.aufirst=David&rft.date=2002-09-01&rft.volume=47&rft.issue=7&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Canadian+journal+of+psychiatry.+Revue+canadienne+de+psychiatrie&rft.issn=07067437&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-29 N1 - Date created - 2002-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cerebrospinal fluid monoamine metabolites in cocaine patients: no relationship to cue-induced craving. AN - 72096714; 12236629 AB - We aimed to examine the relationship between central monoamine metabolites and craving cocaine in cocaine-dependent patients. Cerebrospinal fluid (CSF) monoamine metabolite concentrations were determined in 20 withdrawn cocaine-dependent patients. Patients also participated in a cue-elicited cocaine craving procedure. There were no significant relationships between cocaine craving scores and CSF concentrations of the dopamine metabolite, homovanillic acid, the serotonin metabolite, 5-hydroxyindoleacetic acid, or the norepinephrine metabolite, 3-methoxy-4-hydroxyphenylethylglycol. CSF monoamine metabolite concentrations were not related to cocaine craving in withdrawn cocaine-dependent patients. JF - Journal of psychopharmacology (Oxford, England) AU - Roy, Alec AU - Berman, Jeffrey AU - Gonzalez, Bienvenido AU - Roy, Monique AD - Psychiatry Service, Department of Veterans Affairs, New Jersey Healthcare System, East Orange 07018, USA. Alec.Roy@med.va.gov Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 227 EP - 229 VL - 16 IS - 3 SN - 0269-8811, 0269-8811 KW - Serotonin KW - 333DO1RDJY KW - Methoxyhydroxyphenylglycol KW - 534-82-7 KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Norepinephrine KW - X4W3ENH1CV KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Norepinephrine -- physiology KW - Substance Abuse Treatment Centers KW - Serotonin -- physiology KW - Humans KW - Adult KW - Dopamine -- physiology KW - Cues KW - Male KW - Female KW - Homovanillic Acid -- cerebrospinal fluid KW - Cocaine-Related Disorders -- cerebrospinal fluid KW - Motivation KW - Methoxyhydroxyphenylglycol -- cerebrospinal fluid KW - Cocaine-Related Disorders -- psychology KW - Hydroxyindoleacetic Acid -- cerebrospinal fluid KW - Substance Withdrawal Syndrome -- psychology KW - Substance Withdrawal Syndrome -- cerebrospinal fluid KW - Cocaine-Related Disorders -- rehabilitation KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72096714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychopharmacology+%28Oxford%2C+England%29&rft.atitle=Cerebrospinal+fluid+monoamine+metabolites+in+cocaine+patients%3A+no+relationship+to+cue-induced+craving.&rft.au=Roy%2C+Alec%3BBerman%2C+Jeffrey%3BGonzalez%2C+Bienvenido%3BRoy%2C+Monique&rft.aulast=Roy&rft.aufirst=Alec&rft.date=2002-09-01&rft.volume=16&rft.issue=3&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychopharmacology+%28Oxford%2C+England%29&rft.issn=02698811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-07 N1 - Date created - 2002-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Valganciclovir: A new oral alternative for cytomegalovirus retinitis in human immunodeficiency virus-seropositive individuals. AN - 72083103; 12222548 AB - Oral valganciclovir recently was approved by the Food and Drug Administration for treatment of cytomegalovirus (CMV) retinitis. We performed MEDLINE (June 1998-May 2002) and AIDSLINE (June 1998-December 2000) searches of available information on valganciclovir, and the drug's prescribing information was used to identify relevant articles. Additional studies, case reports, reviews, and abstracts were identified from references in the reviewed literature. Most of the information was obtained from abstracts or product labeling, since few trials have been published in the medical literature. Valganciclovir is a prodrug of ganciclovir and has been shown to have significantly higher oral absorption than ganciclovir capsules. One short-term study found valganciclovir to be as effective as intravenous ganciclovir in treating CMV retinitis. Recommended dosages for patients with normal renal function are valganciclovir 900 mg twice/day for induction and 900 mg once/day for maintenance. Side effects are similar to those of intravenous ganciclovir and require periodic monitoring of complete blood count and renal function. Given the need for lifelong therapy for CMV retinitis in some human immunodeficiency virus-positive patients, valganciclovir is a welcome alternative to long-term administration of intravenous antivirals. JF - Pharmacotherapy AU - Segarra-Newnham, Marisel AU - Salazar, Martha I AD - Veterans Affairs Medical Center, Patient Support Service, West Palm Beach, Florida 33410-6400, USA. marisel.segarra-newnham@med.va.gov Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 1124 EP - 1128 VL - 22 IS - 9 SN - 0277-0008, 0277-0008 KW - Antiviral Agents KW - 0 KW - valganciclovir KW - GCU97FKN3R KW - Ganciclovir KW - P9G3CKZ4P5 KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Drug Interactions KW - Humans KW - Clinical Trials as Topic KW - HIV Seropositivity -- economics KW - Antiviral Agents -- therapeutic use KW - Cytomegalovirus Retinitis -- drug therapy KW - Antiviral Agents -- administration & dosage KW - Ganciclovir -- therapeutic use KW - Ganciclovir -- pharmacokinetics KW - Ganciclovir -- administration & dosage KW - Antiviral Agents -- economics KW - HIV Seropositivity -- complications KW - Antiviral Agents -- pharmacokinetics KW - Cytomegalovirus Retinitis -- economics KW - Antiviral Agents -- pharmacology KW - Ganciclovir -- adverse effects KW - Antiviral Agents -- adverse effects KW - Ganciclovir -- analogs & derivatives KW - Ganciclovir -- economics KW - Ganciclovir -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72083103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Valganciclovir%3A+A+new+oral+alternative+for+cytomegalovirus+retinitis+in+human+immunodeficiency+virus-seropositive+individuals.&rft.au=Segarra-Newnham%2C+Marisel%3BSalazar%2C+Martha+I&rft.aulast=Segarra-Newnham&rft.aufirst=Marisel&rft.date=2002-09-01&rft.volume=22&rft.issue=9&rft.spage=1124&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-17 N1 - Date created - 2002-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Current concepts in radiation enteritis and implications for future clinical trials. AN - 72059129; 12209703 AB - Radiation enteritis is one of the most feared complications of abdominal and pelvic radiation. Once its occurs, the process is relentless and may result in the patient's death. Available treatment is only supportive. Recent progress in molecular biology has shed some light on the pathogenesis of radiation enteritis and other diseases that are characterized by excessive fibrosis. New treatment modalities may be devised to improve the outcome of patients who are affected with this complication. A literature search was used to identify the common denominator between many radiation-induced fibrotic conditions and other sclerotic diseases. Factors that affect the disease process and possible therapeutic interventions were evaluated. The hyperstimulation of transforming growth factor beta1 (TGF-beta1) leads to increased fibrosis and, ultimately, organ failure. Interferon gamma (IFN-gamma) inhibits the effects of TGF-beta1 in the nucleus. The fibrotic process may be reverted by IFN-gamma in various pathologic conditions. Radiation enteritis and other radiation-induced, long-term complications are characterized by excessive stimulation of TGF-beta1. Preliminary studies suggest that IFN-gamma may be effective in the treatment of patients with radiation-induced cutaneous fibrosis. IFN-gamma should be considered in Phase I-II studies to assess its toxicity and efficacy in the treatment of patients with radiation enteritis. Copyright 2002 American Cancer Society. JF - Cancer AU - Nguyen, Nam P AU - Antoine, John E AU - Dutta, Suresh AU - Karlsson, Ulf AU - Sallah, Sabah AD - Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, 75216, USA. namphong.nguyen@med.va.gov Y1 - 2002/09/01/ PY - 2002 DA - 2002 Sep 01 SP - 1151 EP - 1163 VL - 95 IS - 5 SN - 0008-543X, 0008-543X KW - Antineoplastic Agents KW - 0 KW - TGFB1 protein, human KW - Transforming Growth Factor beta KW - Transforming Growth Factor beta1 KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Fibrosis -- etiology KW - Humans KW - Clinical Trials as Topic KW - Abdominal Neoplasms -- radiotherapy KW - Enteritis -- etiology KW - Transforming Growth Factor beta -- pharmacology KW - Interferon-gamma -- therapeutic use KW - Enteritis -- physiopathology KW - Interferon-gamma -- pharmacology KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Radiotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72059129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Current+concepts+in+radiation+enteritis+and+implications+for+future+clinical+trials.&rft.au=Nguyen%2C+Nam+P%3BAntoine%2C+John+E%3BDutta%2C+Suresh%3BKarlsson%2C+Ulf%3BSallah%2C+Sabah&rft.aulast=Nguyen&rft.aufirst=Nam&rft.date=2002-09-01&rft.volume=95&rft.issue=5&rft.spage=1151&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-09-17 N1 - Date created - 2002-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - SWOG-9510: evaluation of topotecan in hormone refractory prostate cancer: a Southwest Oncology Group study. AN - 72056596; 12210486 AB - Prostate cancer is the most common malignancy in American men, and as many as 70% of those initially treated for localized disease will ultimately progress and be considered candidates to receive therapy for metastatic cancer [Fuks et al.: Int J Radiat Oncol Bio Phys 21:537-547, 1991; Chodak et al.: N Engl J Med 330:246-248, 1994]. Although most will respond initially to hormone manipulation, essentially all will fail and require additional therapy. No standard chemotherapy approach has been shown to prolong survival significantly, and new agents are desperately needed. Topotecan is a new topoisomerase-1 inhibitor whose early investigation suggested possible activity in hormone-refractory prostate cancer. In this phase II trial, patients having failed one or two prior androgen ablative therapies were treated with 21-day continuous intravenous infusions of topotecan at a dose of 0.5 mg/m(2) per day every 28 days. Twenty-six eligible patients were entered on the study. There were no confirmed tumor responses. Median survival was 9 months. The most common toxicities were hematologic, with 8 of 24 assessable patients experiencing grade 4 toxicity. Topotecan infusions at this dose are ineffective in the management of hormone-refractory prostate cancer. Copyright 2002 Wiley-Liss, Inc. JF - The Prostate AU - Klein, Catherine E AU - Tangen, Catherine M AU - Braun, Thomas J AU - Hussain, Maha H A AU - Peereboom, David M AU - Nichols, Craig R AU - Rivkin, Saul E AU - Dakhil, Shaker R AU - Crawford, E David AD - University of Colorado, Denver, Colorado, USA. catherine.klein@med.va.gov Y1 - 2002/09/01/ PY - 2002 DA - 2002 Sep 01 SP - 264 EP - 268 VL - 52 IS - 4 SN - 0270-4137, 0270-4137 KW - Antineoplastic Agents KW - 0 KW - Topotecan KW - 7M7YKX2N15 KW - Index Medicus KW - Infusions, Intravenous KW - Aged, 80 and over KW - Humans KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Drug Resistance, Neoplasm KW - Male KW - Survival Analysis KW - Prostatic Neoplasms -- pathology KW - Antineoplastic Agents -- administration & dosage KW - Topotecan -- pharmacology KW - Topotecan -- administration & dosage KW - Prostatic Neoplasms -- drug therapy KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72056596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Prostate&rft.atitle=SWOG-9510%3A+evaluation+of+topotecan+in+hormone+refractory+prostate+cancer%3A+a+Southwest+Oncology+Group+study.&rft.au=Klein%2C+Catherine+E%3BTangen%2C+Catherine+M%3BBraun%2C+Thomas+J%3BHussain%2C+Maha+H+A%3BPeereboom%2C+David+M%3BNichols%2C+Craig+R%3BRivkin%2C+Saul+E%3BDakhil%2C+Shaker+R%3BCrawford%2C+E+David&rft.aulast=Klein&rft.aufirst=Catherine&rft.date=2002-09-01&rft.volume=52&rft.issue=4&rft.spage=264&rft.isbn=&rft.btitle=&rft.title=The+Prostate&rft.issn=02704137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-09-17 N1 - Date created - 2002-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Amphetamine usage and genital self-mutilation. AN - 72041289; 12199837 AB - Amphetamine usage has been associated with addiction, psychosis and self-injurious behavior. We report on two patients who severely and repeatedly mutilated their own genitalia while intoxicated on amphetamines and consider possible diagnostic etiologies. JF - Addiction (Abingdon, England) AU - Israel, Joshua A AU - Lee, Kewchang AD - Consultation-Liason Psychiatry Service, San Francisco Veterans Affairs Medical Center/University of California, San Francisco School of Medicine, 94121, USA. Joshua.Israel@med.va.gov Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 1215 EP - 1218 VL - 97 IS - 9 SN - 0965-2140, 0965-2140 KW - Central Nervous System Stimulants KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Rectum -- injuries KW - Methamphetamine -- adverse effects KW - Genitalia, Male -- injuries KW - Substance-Related Disorders -- complications KW - Central Nervous System Stimulants -- adverse effects KW - Substance-Related Disorders -- psychology KW - Self Mutilation -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72041289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Amphetamine+usage+and+genital+self-mutilation.&rft.au=Israel%2C+Joshua+A%3BLee%2C+Kewchang&rft.aulast=Israel&rft.aufirst=Joshua&rft.date=2002-09-01&rft.volume=97&rft.issue=9&rft.spage=1215&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-12-05 N1 - Date created - 2002-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcohol. AN - 72040112; 12198667 AB - Steatosis has emerged as a histologic finding of importance to the progression of hepatitis C virus (HCV)-associated liver disease. However, most studies of HCV-associated steatosis have excluded alcohol drinkers and individuals with diabetes and thus have not addressed the relative contribution of known causes of steatosis to liver injury in HCV-associated disease. To address this issue, we studied 297 consecutive patients with HCV who met inclusion criteria. Alcohol consumption, demographics, and serologic tests were correlated with degrees of steatosis and fibrosis on liver biopsy. Liver biopsy specimens were also examined for evidence of significant alcohol or nonalcoholic steatohepatitis (NASH) injury. In univariate analysis, steatosis correlated with type 2 diabetes mellitus (P =.005) and body mass index (BMI) (P =.0001) but not with the intensity of alcohol intake (in grams per day). In multivariate analysis, BMI (P =.0002) and genotype 3a infection (P =.02) were independent predictors of steatosis. When patients with risk factors for NASH were excluded, genotype 3a infection was the only independent predictor of steatosis. Steatosis (P =.04) and inflammation (P <.0001) scores on liver biopsy were the only independent predictors of fibrosis. Significant alcohol or NASH injury was found in only 6% of biopsy specimens. In conclusion, steatosis in HCV infection is associated with risk factors for NASH, particularly obesity, rather than alcohol consumption. JF - Hepatology (Baltimore, Md.) AU - Monto, Alexander AU - Alonzo, Judy AU - Watson, Jessica J AU - Grunfeld, Carl AU - Wright, Teresa L AD - Department of Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, CA 94121, USA. Alexander.Monto@med.va.gov Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 729 EP - 736 VL - 36 IS - 3 SN - 0270-9139, 0270-9139 KW - Index Medicus KW - Liver Cirrhosis -- pathology KW - Liver -- pathology KW - Liver Cirrhosis -- virology KW - Humans KW - Biopsy KW - Alcohol Drinking -- epidemiology KW - Multivariate Analysis KW - Risk Factors KW - Adult KW - Liver Cirrhosis -- epidemiology KW - Middle Aged KW - Female KW - Male KW - Fatty Liver, Alcoholic -- virology KW - Fatty Liver, Alcoholic -- epidemiology KW - Hepatitis C, Chronic -- epidemiology KW - Diabetes Mellitus, Type 2 -- epidemiology KW - Fatty Liver, Alcoholic -- pathology KW - Obesity -- epidemiology KW - Hepatitis C, Chronic -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72040112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Steatosis+in+chronic+hepatitis+C%3A+relative+contributions+of+obesity%2C+diabetes+mellitus%2C+and+alcohol.&rft.au=Monto%2C+Alexander%3BAlonzo%2C+Judy%3BWatson%2C+Jessica+J%3BGrunfeld%2C+Carl%3BWright%2C+Teresa+L&rft.aulast=Monto&rft.aufirst=Alexander&rft.date=2002-09-01&rft.volume=36&rft.issue=3&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-09-27 N1 - Date created - 2002-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Predictors of alkalosis after liver transplantation. AN - 72038941; 12200803 AB - Metabolic alkalosis (MA) is common after orthotopic liver transplantation (OLT). The study was conducted to identify factors associated with MA after 285 OLTs. MA, defined as total carbon dioxide content of 30 mEq/L or greater, developed in 115 patients (40%) within the first 3 postoperative days. By univariate analysis, patients with MA had a greater preoperative carbon dioxide content (24.4 +/- 3 versus 22.9 +/- 2.9 mEq/L; P < 0.0001) and hematocrit (35% +/- 5% versus 33% +/- 6%; P < 0.02), but lower creatinine (0.9 +/- 0.5 versus 1.2 +/- 1.2 mg/dL; P < 0.001) and blood urea nitrogen levels (15 +/- 12 versus 19 +/- 17 mg/dL; P < 0.001) compared with controls. Patients with MA were administered more citrate intraoperatively compared with controls (6.2 +/- 5.2 versus 4.5 +/- 3.6 mEq/kg of body weight; P < 0.02). Patients with MA had a lower postoperative potassium level (3.7 +/- 0.4 versus 4 +/- 0.5 mEq/L; P < 0.0001) and cumulative fluid balance (-0.66 +/- 1.87 versus +0.003 +/- 3.9 L; P < 0.007) compared with controls. By multivariate analysis, preoperative carbon dioxide content (odds ratio, 1.19; 95% confidence interval [CI], 1.08 to 1.31 per mEq/L), creatinine level (odds ratio, 0.61; 95% CI, 0.39 to 0.96 per mg/dL), intraoperative administered citrate (odds ratio, 3.35; 95% CI, 1.71 to 6.53 per 10 mEq/kg body weight), and postoperative potassium level (odds ratio, 0.32; 95% CI, 0.18 to 0.57 per mEq/L) were independently associated with MA. MA was not associated with increased hospital mortality (7.8% versus 8.2%, MA versus controls). However, patients with MA spent more time on mechanical ventilation than controls (5 +/- 0.8 versus 3 +/- 0.6 days; P < or = 0.03). Preoperative total carbon dioxide content, renal function, intraoperative administered citrate, and postoperative potassium level are independently associated with MA after primary OLT. Copyright 2002 by the National Kidney Foundation, Inc. JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Contreras, Gabriel AU - Garces, Galo AU - Reich, James AU - Banerjee, Debasish AU - Young, Larry AU - Cely, Cynthia AU - Gadalean, Florin AU - Perez, Guido AU - Roth, David AD - Veterans Affairs Medical Center and University of Miami School of Medicine, Miami, FL 33125, USA. gabriel.contreras@med.va.gov Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 517 EP - 524 VL - 40 IS - 3 KW - Bicarbonates KW - 0 KW - Carbon Dioxide KW - 142M471B3J KW - Citric Acid KW - 2968PHW8QP KW - Index Medicus KW - Kidney Function Tests KW - Bicarbonates -- adverse effects KW - Infusions, Intravenous KW - Citric Acid -- metabolism KW - Databases as Topic KW - Humans KW - Retrospective Studies KW - Kidney -- physiology KW - Predictive Value of Tests KW - Intraoperative Care -- methods KW - Bicarbonates -- blood KW - Citric Acid -- adverse effects KW - Multivariate Analysis KW - Preoperative Care -- methods KW - Citric Acid -- administration & dosage KW - Hypokalemia -- complications KW - Middle Aged KW - Bicarbonates -- metabolism KW - Water-Electrolyte Balance KW - Carbon Dioxide -- blood KW - Male KW - Kidney -- physiopathology KW - Female KW - Prevalence KW - Alkalosis -- etiology KW - Alkalosis -- mortality KW - Alkalosis -- blood KW - Liver Transplantation -- adverse effects KW - Alkalosis -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72038941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Predictors+of+alkalosis+after+liver+transplantation.&rft.au=Contreras%2C+Gabriel%3BGarces%2C+Galo%3BReich%2C+James%3BBanerjee%2C+Debasish%3BYoung%2C+Larry%3BCely%2C+Cynthia%3BGadalean%2C+Florin%3BPerez%2C+Guido%3BRoth%2C+David&rft.aulast=Contreras&rft.aufirst=Gabriel&rft.date=2002-09-01&rft.volume=40&rft.issue=3&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=1523-6838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-09-13 N1 - Date created - 2002-08-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genotypic Diversity of Clinical Actinomyces Species: Phenotype, Source, and Disease Correlation among Genospecies AN - 18473900; 5439762 AB - We determined the frequency distribution of Actinomyces spp. recovered in a routine clinical laboratory and investigated the clinical significance of accurate identification to the species level. We identified 92 clinical strains of Actinomyces, including 13 strains in the related Arcanobacterium- Actinobaculum taxon, by 16S rRNA gene sequence analysis and recorded their biotypes, sources, and disease associations. The clinical isolates clustered into 21 genogroups. Twelve genogroups (74 strains) correlated with a known species, and nine genogroups (17 strains) did not. The individual species had source and disease correlates. Actinomyces turicensis was the most frequently isolated species and was associated with genitourinary tract specimens, often with other organisms and rarely with inflammatory cells. Actinomyces radingae was most often associated with serious, chronic soft tissue abscesses of the breast, chest, and back. Actinomyces europaeus was associated with skin abscesses of the neck and genital areas. Actinomyces lingnae, Actinomyces gravenitzii, Actinomyces odontolyticus, and Actinomyces meyeri were isolated from respiratory specimens, while A. odontolyticus-like strains were isolated from diverse sources. Several of the species were commonly coisolated with a particular bacterium: Actinomyces israelii was the only Actinomyces spp. coisolated with Actinobacillus (Haemophilus) actinomycetemcomitans; Actinomyces meyeri was coisolated with Peptostreptococcus micros and was the only species other than A. israelii associated with sulfur granules in histological specimens. Most genogroups had consistent biotypes (as determined with the RapID ANA II system); however, strains were misidentified, and many codes were not in the database. One biotype was common to several genogroups, with all of these isolates being identified as A. meyeri. Despite the recent description of new Actinomyces spp., 19% of the isolates recovered in our routine laboratory belonged to novel genospecies. One novel group with three strains, Actinomyces houstonensis sp. nov., was phenotypically similar to A. meyeri and A. turicensis but was genotypically closest to Actinomyces neuii. A. houstonensis sp. nov. was associated with abscesses. Our data documented consistent site and disease associations for 21 genogroups of Actinomyces spp. that provide greater insights into appropriate treatments. However, we also demonstrated a complexity within the Actinomyces genus that compromises the biochemical identification of Actinomyces that can be performed in most clinical laboratories. It is our hope that this large group of well-defined strains will be used to find a simple and accurate biochemical test for differentiation of the species in routine laboratories. JF - Journal of Clinical Microbiology AU - Clarridge, JE III AU - Zhang, Q AD - VA Puget Sound Health Care System, Seattle, WA 98102, jill.clarridge@med.va.gov Y1 - 2002/09// PY - 2002 DA - Sep 2002 SP - 3442 EP - 3448 VL - 40 IS - 9 SN - 0095-1137, 0095-1137 KW - genitourinary tract KW - Microbiology Abstracts B: Bacteriology KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18473900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Genotypic+Diversity+of+Clinical+Actinomyces+Species%3A+Phenotype%2C+Source%2C+and+Disease+Correlation+among+Genospecies&rft.au=Clarridge%2C+JE+III%3BZhang%2C+Q&rft.aulast=Clarridge&rft.aufirst=JE&rft.date=2002-09-01&rft.volume=40&rft.issue=9&rft.spage=3442&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.40.9.3442-3448.2002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1128/JCM.40.9.3442-3448.2002 ER - TY - JOUR T1 - Taxonomic Subgroups of Pasteurella multocida Correlate with Clinical Presentation AN - 18472001; 5439746 AB - Pasteurella multocida is a small nonmotile gram-negative coccobacillus that is found in the nasopharynx and gastrointestinal tract of many wild and domesticated animals. In humans it most commonly causes cellulitis and localized superficial skin abscesses following an animal bite or scratch. The respiratory tract is the second most common site of infection for Pasteurella. Of the more than 17 species of Pasteurella known, Pasteurella multocida subsp. multocida and Pasteurella multocida subsp. septica are among the most common pathogens in humans. With the use of molecular techniques, distinction between different subspecies of P. multocida can be made more easily and accurately. We used the sequence of the 16S ribosomal DNA (rDNA) and repetitive extragenic palindromic sequence-PCR (REP-PCR) to characterize 20 strains (14 of P. multocida subsp. multocida and 6 of P. multocida subsp. septica; the 16S rDNA is identical for P. multocida subsp. multocida and Pasteurella multocida subsp. gallicida but differs from that of P. multocida subsp. septica) isolated from various anatomic sites. We found excellent correlation between the 16S rDNA sequence (a marker for a small conserved region of the genome), REP-PCR (a marker for a large portion of the genome), and biochemical tests (trehalose and sorbitol). We also found a correlation between the clinical presentation and the taxonomic group, with P. multocida subsp. septica more often associated with wounds than with respiratory infections (67 versus 17%, respectively) (P < 0.05, Z test) and P. multocida subsp. multocida more often associated with respiratory infections than with wounds (71 versus 14%, respectively) (P < 0.05, Z test). JF - Journal of Clinical Microbiology AU - Chen, H I AU - Hulten, K AU - Clarridge III, JE AD - VA Puget Sound Health Care System, Seattle, WA 98102, jill.clarridge@med.va.gov Y1 - 2002/09// PY - 2002 DA - Sep 2002 SP - 3438 EP - 3441 VL - 40 IS - 9 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - J 02710:Identification, taxonomy and typing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18472001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Taxonomic+Subgroups+of+Pasteurella+multocida+Correlate+with+Clinical+Presentation&rft.au=Chen%2C+H+I%3BHulten%2C+K%3BClarridge+III%2C+JE&rft.aulast=Chen&rft.aufirst=H&rft.date=2002-09-01&rft.volume=40&rft.issue=9&rft.spage=3438&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.40.9.3438-3441.2002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1128/JCM.40.9.3438-3441.2002 ER - TY - JOUR T1 - Nefazodone in the treatment of patients with post-traumatic stress disorder AN - 1008831239; 16482600 AB - Post-traumatic stress disorder occurs in patients who have undergone a traumatic experience and manifests itself through a cluster of symptoms, including re-experiencing, avoidance and hyperarousal. Post-traumatic stress disorder is commonly found among veterans of war and victims of sexual trauma, natural disasters and accidents. Nefazodone is a medication that has an FDA-approved indication for treating depression. Nefazodone has also been reported to be efficacious in treating post-traumatic stress disorder. Despite recent reports of hepatotoxicity, when used appropriately, nefazodone is generally as well-tolerated as the medications currently FDA-indicated for post-traumatic stress disorder, the selective serotonin reuptake inhibitors. Through its mechanism inhibiting neuronal uptake of serotonin and norepinephrine and as a potent postsynaptic serotonergic antagonist, nefazodone has proven to be effective in treating post-traumatic stress disorder in several open-label trials. The results of such trials warrant its study in larger, double-blind, placebo-controlled clinical trials. JF - Expert Review of Neurotherapeutics AU - Sharpe, Rachel H AU - Voris, John C AD - Extended Care and Primary Care Services, Dorn VA Medical Center, 6439 Garner's Ferry Road, Columbia, SC 29209, USA. Rachel.Sharpeed.va.gov Y1 - 2002/09// PY - 2002 DA - Sep 2002 SP - 617 EP - 623 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 2 IS - 5 SN - 1473-7175, 1473-7175 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Accidents KW - Clinical trials KW - Depression KW - Military personnel KW - Nefazodone KW - Norepinephrine KW - Post-traumatic stress disorder KW - Serotonin uptake inhibitors KW - Trauma KW - War KW - hepatotoxicity KW - natural disasters KW - X 24310:Pharmaceuticals KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008831239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Review+of+Neurotherapeutics&rft.atitle=Nefazodone+in+the+treatment+of+patients+with+post-traumatic+stress+disorder&rft.au=Sharpe%2C+Rachel+H%3BVoris%2C+John+C&rft.aulast=Sharpe&rft.aufirst=Rachel&rft.date=2002-09-01&rft.volume=2&rft.issue=5&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Expert+Review+of+Neurotherapeutics&rft.issn=14737175&rft_id=info:doi/10.1586%2F14737175.2.5.617 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Accidents; Nefazodone; Depression; natural disasters; War; Norepinephrine; Serotonin uptake inhibitors; Clinical trials; Post-traumatic stress disorder; hepatotoxicity; Military personnel; Trauma DO - http://dx.doi.org/10.1586/14737175.2.5.617 ER - TY - JOUR T1 - Topiramate antagonizes MK-801 in an animal model of schizophrenia. AN - 71987613; 12163115 AB - The phencyclidine (PCP) model of schizophrenia suggests that N-methyl-D-aspartate (NMDA) receptor hypofunction and its consequences may play an important role in the pathophysiology of this psychiatric disorder. Moreover, the schizophreniform psychosis caused by PCP resembles schizophrenia in all of the relevant domains of psychopathology, especially negative symptoms and cognitive dysfunction. Because of interest in the PCP model and possible NMDA receptor hypofunction in schizophrenia, animal behaviors elicited by PCP and its analogues have been characterized. These preclinical models may serve to identify candidate compounds that possess therapeutic efficacy in schizophrenia. Ideally, negative symptoms and cognitive dysfunction would also serve as therapeutic targets for these novel medications. In the current study, the ability of topiramate to attenuate the severity of a specific behavior elicited by MK-801 (dizocilpine), a high affinity analogue of PCP was studied in mice. Topiramate was chosen because it addresses two of the predicted pathological consequences of NMDA receptor hypofunction. Specifically, topiramate potentiates GABAergic neurotransmission and antagonizes the excitotoxic actions of glutamate at the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate (KA) classes of glutamate-gated channels. Topiramate was shown to inhibit MK-801-elicited "popping" behavior in a complex dose-dependent manner. JF - European journal of pharmacology AU - Deutsch, Stephen I AU - Rosse, Richard B AU - Billingslea, Eddie N AU - Bellack, Alan S AU - Mastropaolo, John AD - Mental Health Service Line, Veterans Integrated Service Network 5, 849 International Drive, Suite 275, Linthicum, MD 21090, USA. Stephen.Deutsch@med.va.gov Y1 - 2002/08/02/ PY - 2002 DA - 2002 Aug 02 SP - 121 EP - 125 VL - 449 IS - 1-2 SN - 0014-2999, 0014-2999 KW - Antipsychotic Agents KW - 0 KW - Excitatory Amino Acid Antagonists KW - Hallucinogens KW - Neuroprotective Agents KW - topiramate KW - 0H73WJJ391 KW - Fructose KW - 30237-26-4 KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - Phencyclidine KW - J1DOI7UV76 KW - Index Medicus KW - Animals KW - Phencyclidine -- toxicity KW - Dose-Response Relationship, Drug KW - Mice KW - Phencyclidine -- analogs & derivatives KW - Hallucinogens -- toxicity KW - Male KW - Behavior, Animal -- drug effects KW - Excitatory Amino Acid Antagonists -- toxicity KW - Fructose -- analogs & derivatives KW - Dizocilpine Maleate -- antagonists & inhibitors KW - Antipsychotic Agents -- pharmacology KW - Schizophrenia -- prevention & control KW - Dizocilpine Maleate -- toxicity KW - Schizophrenic Psychology KW - Schizophrenia -- chemically induced KW - Neuroprotective Agents -- toxicity KW - Fructose -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71987613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Topiramate+antagonizes+MK-801+in+an+animal+model+of+schizophrenia.&rft.au=Deutsch%2C+Stephen+I%3BRosse%2C+Richard+B%3BBillingslea%2C+Eddie+N%3BBellack%2C+Alan+S%3BMastropaolo%2C+John&rft.aulast=Deutsch&rft.aufirst=Stephen&rft.date=2002-08-02&rft.volume=449&rft.issue=1-2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-20 N1 - Date created - 2002-08-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationships between Language-Based Disability and Quality of Life in Chronically Aphasic Adults AN - 85563643; 200302142 AB - We examined relationships between residual language &/or communication deficits & quality of life (QOL) to determine whether, within non-brain-injured (NBI) adult & chronically aphasic adult groups, there are significant relationships between (1) language impairment & QOL measures & (2) communication activity limitation & QOL measures; &, whether the strengths of these relationships differ between groups. Adults with chronic aphasia & NBI controls (N = 18 each) were administered two language impairment tests, two communication activity limitation assessments, & two QOL measures. Although chronically aphasic adults scored significantly lower on all measures than did NBI adults, language-based disability generally was not significantly related with QOL in either group. The results of this investigation may be interpreted to suggest that decreased QOL in chronically aphasic adults is not closely related with language-based disablement. Thus, speech therapy that directly targets QOL in aphasic patients may not be justified. 4 Tables, 28 References. Adapted from the source document JF - Aphasiology AU - Ross, Katherine B AU - Wertz, Robert T AD - Audiology & Speech Pathology Dept, Carl T. Hayden Veterans Affairs Medical Center, Phoenix, AZ katherine.ross3@med.va.gov Y1 - 2002/08// PY - 2002 DA - August 2002 SP - 791 EP - 800 VL - 16 IS - 8 SN - 0268-7038, 0268-7038 KW - quality of life KW - Psychometric Analysis (69210) KW - Aphasia (03400) KW - Language Pathology (43250) KW - Communicative Competence (13650) KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85563643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=Relationships+between+Language-Based+Disability+and+Quality+of+Life+in+Chronically+Aphasic+Adults&rft.au=Ross%2C+Katherine+B%3BWertz%2C+Robert+T&rft.aulast=Ross&rft.aufirst=Katherine&rft.date=2002-08-01&rft.volume=16&rft.issue=8&rft.spage=791&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - Aphasia (03400); Language Pathology (43250); Communicative Competence (13650); Psychometric Analysis (69210) ER - TY - JOUR T1 - A brief telephone intervention targeting treatment engagement from a substance abuse program wait list. AN - 72069091; 12216373 AB - This study compares three brief participant-initiated telephone interventions aimed at enhancing treatment engagement of individuals on a substance abuse treatment wait list. Policies requiring that wait list members call at least every other week in order to remain eligible for treatment remained in place for the standard and enhanced conditions but not for the voluntary condition. The standard condition was a minimal intervention, providing information on the program. The enhanced condition focused on client motivation for treatment and recovery. If individuals in the voluntary condition called, they were provided information about current wait list number and approximate remaining wait time. The rate of treatment engagement was the same among treatment conditions. The best predictor of engagement was the number of calls placed to the program while waiting. Treatment condition was a positive predictor of call frequency; presence of a comorbid psychiatric diagnosis was a negative predictor. The article also discusses future directions. JF - The journal of behavioral health services & research AU - Parker, Jefferson D AU - Turk, Cynthia L AU - Busby, Lisa D AD - Chemical Dependence Treatment Program, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, 1500 E Woodrow Wilson Drive, 116A4, Jackson, MS 39216, USA. jefferson.parker@med.va.gov Y1 - 2002/08// PY - 2002 DA - August 2002 SP - 288 EP - 303 VL - 29 IS - 3 SN - 1094-3412, 1094-3412 KW - Index Medicus KW - Severity of Illness Index KW - Interview, Psychological KW - Motivation KW - Humans KW - Health Services Research KW - Adult KW - Patient Admission -- statistics & numerical data KW - Mississippi KW - Self Efficacy KW - Middle Aged KW - Data Collection KW - Hospitals, Veterans -- utilization KW - Male KW - Telephone KW - Substance Abuse Treatment Centers -- organization & administration KW - Patient Compliance -- psychology KW - Veterans -- psychology KW - Waiting Lists KW - Substance-Related Disorders -- rehabilitation KW - Substance Abuse Treatment Centers -- utilization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72069091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+behavioral+health+services+%26+research&rft.atitle=A+brief+telephone+intervention+targeting+treatment+engagement+from+a+substance+abuse+program+wait+list.&rft.au=Parker%2C+Jefferson+D%3BTurk%2C+Cynthia+L%3BBusby%2C+Lisa+D&rft.aulast=Parker&rft.aufirst=Jefferson&rft.date=2002-08-01&rft.volume=29&rft.issue=3&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=The+journal+of+behavioral+health+services+%26+research&rft.issn=10943412&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-01 N1 - Date created - 2002-09-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Patient preferences for treatment of lupus nephritis. AN - 72058766; 12209490 AB - To examine the amount of improvement in renal survival that lupus patients require before choosing cyclophosphamide over azathioprine for the treatment of lupus nephritis. Patients were presented with descriptions of cyclophosphamide and azathioprine and asked to indicate their preferred choice if each conferred an equal probability of renal survival. Strength of preference was assessed by systematically increasing the probability of renal survival of the more toxic treatment until the respondent's choice switched. Ninety-three well-educated women (mean age +/- SD 40 +/- 7 years) participated in the study. Ninety-eight percent (91/93) of the participants chose azathioprine over cyclophosphamide when both drugs conferred an equal probability of renal survival. Although most subjects switched preferences to cyclophosphamide for better renal survival, 31% (28/91) were unwilling to switch from azathioprine to cyclophosphamide for improved short-term renal survival, and 15% (14/91) were unwilling to switch from azathioprine to cyclophosphamide for improved long-term renal survival. Although the majority of patients switched preferences to cyclophosphamide for better renal survival, a substantial minority was unwilling to accept the toxicity associated with cyclophosphamide, even if it was much better than azathioprine at preventing renal failure. JF - Arthritis and rheumatism AU - Fraenkel, Liana AU - Bogardus, Sidney AU - Concato, John AD - Yale University, New Haven, Connecticut and Veterans Administration Connecticut Healthcare System, West Haven, Connecticut 06520-8031, USA. liana.fraenkel@med.va.gov Y1 - 2002/08// PY - 2002 DA - August 2002 SP - 421 EP - 428 VL - 47 IS - 4 SN - 0004-3591, 0004-3591 KW - Cyclophosphamide KW - 8N3DW7272P KW - Azathioprine KW - MRK240IY2L KW - Abridged Index Medicus KW - Index Medicus KW - Hospitals, University KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Adolescent KW - Female KW - Community Medicine KW - Lupus Nephritis -- drug therapy KW - Patient Satisfaction KW - Azathioprine -- adverse effects KW - Lupus Nephritis -- psychology KW - Health Knowledge, Attitudes, Practice KW - Cyclophosphamide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72058766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+and+rheumatism&rft.atitle=Patient+preferences+for+treatment+of+lupus+nephritis.&rft.au=Fraenkel%2C+Liana%3BBogardus%2C+Sidney%3BConcato%2C+John&rft.aulast=Fraenkel&rft.aufirst=Liana&rft.date=2002-08-01&rft.volume=47&rft.issue=4&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Arthritis+and+rheumatism&rft.issn=00043591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-09-19 N1 - Date created - 2002-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Indoor environmental exposures and symptoms. AN - 72029923; 12194903 AB - The label "sick building syndrome" is often used to imply the absence of a physiologic basis for symptoms in the built environment. Although building-related illness is widely recognized but considered rare, several well-studied mechanisms may be responsible for many symptoms in buildings. These mechanisms do not explain why some individuals perceive disability. Until researchers distinguish physiologic mechanisms from other aspects of disease and study them systematically, poorly defined symptoms will remain poorly understood. The disability associated with such symptoms and syndromes, not the physiology, is the primary interest and generates controversy. JF - Environmental health perspectives AU - Hodgson, Michael AD - Veterans Health Administration, Washington, DC 20420, USA. muh7@mail.va.gov Y1 - 2002/08// PY - 2002 DA - August 2002 SP - 663 EP - 667 VL - 110 Suppl 4 SN - 0091-6765, 0091-6765 KW - Organic Chemicals KW - 0 KW - Index Medicus KW - Occupational Health KW - Humans KW - Volatilization KW - Headache -- etiology KW - Mucous Membrane -- pathology KW - Odorants KW - Air Pollution, Indoor -- adverse effects KW - Sick Building Syndrome -- classification KW - Environmental Exposure KW - Disabled Persons KW - Sick Building Syndrome -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72029923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Indoor+environmental+exposures+and+symptoms.&rft.au=Hodgson%2C+Michael&rft.aulast=Hodgson&rft.aufirst=Michael&rft.date=2002-08-01&rft.volume=110+Suppl+4&rft.issue=&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-01 N1 - Date created - 2002-08-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Indoor Air. 2000 Mar;10(1):2-12 [10842455] Environ Health Perspect. 2001 Sep;109(9):937-41 [11673123] Indoor Air. 2000 Jun;10(2):92-100 [11980107] Eur J Respir Dis. 1981 Oct;62(5):332-43 [7047184] Br Med J (Clin Res Ed). 1984 Dec 8;289(6458):1573-5 [6439323] Acta Ophthalmol (Copenh). 1989 Feb;67(1):61-8 [2773640] Occup Med. 1989 Oct-Dec;4(4):753-70 [2513653] J Occup Med. 1991 Apr;33(4):527-33 [2037908] Arch Environ Health. 1992 Jan-Feb;47(1):45-50 [1540002] Ann N Y Acad Sci. 1992 Apr 30;641:46-55 [1580480] J Occup Med. 1992 Jul;34(7):698-701 [1386626] Am J Public Health. 1993 Jan;83(1):89-93 [8417614] N Engl J Med. 1993 Feb 25;328(8):584 [8426634] Int Arch Occup Environ Health. 1993;65(1):65-9 [8354577] Arch Intern Med. 1994 Oct 24;154(20):2339-45 [7944856] Occup Environ Med. 1994 Oct;51(10):683-8 [8000493] J Occup Environ Med. 1997 Apr;39(4):320-7 [9113602] Am J Rhinol. 1997 Mar-Apr;11(2):167-75 [9129761] Occup Environ Med. 1997 May;54(5):322-7 [9196454] Am J Epidemiol. 1997 Nov 1;146(9):704-11; discussion 712 [9366617] Int J Epidemiol. 1997 Dec;26(6):1250-7 [9447405] JAMA. 1998 Feb 4;279(5):381-3 [9459472] Arch Toxicol. 1998 Feb;72(3):125-40 [9520136] J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):732-40 [9648699] Prog Retin Eye Res. 1998 Oct;17(4):565-96 [9777650] Am J Ind Med. 1998 Nov;34(5):499-505 [9787855] Am J Public Health. 1998 Dec;88(12):1795-800 [9842376] Epidemiol Rev. 1998;20(2):148-56 [9919435] J Occup Environ Med. 1999 Mar;41(3):202-9 [10091144] Indoor Air. 1999 Sep;9(3):165-79 [10439554] Am J Ind Med. 1999 Sep;Suppl 1:55-7 [10519785] Indoor Air. 2000 Sep;10(3):138-45 [10979195] Indoor Air. 2001 Mar;11(1):2-9 [11235228] Arch Environ Health. 2001 Jan-Feb;56(1):30-6 [11256854] Am J Ind Med. 2001 Jun;39(6):616-28 [11385646] Indoor Air. 2001 Jun;11(2):72-86 [11394014] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dynamics of extracellular dopamine in the acute and chronic actions of cocaine. AN - 72027210; 12194500 AB - Cocaine amplifies dopaminergic neurotransmission via blockade of presynaptic neuronal uptake. This action is believed to be a crucial component of cocaine's ability to exert its reinforcing effects. This review will provide a brief overview of extracellular dopamine dynamics associated with cocaine. The acute effects of cocaine reviewed include comparison of intravenous and intraperitoneal routes of administration to better understand how fast and slow routes (e.g., crack and intranasal) differ in their pharmacokinetics and neurochemical effects and how those differences relate to differences in abuse potential. Changes in the acute effects of cocaine within a session have been examined in neurochemical studies of acute tolerance to self-administered cocaine in rhesus monkeys, and the potential impact of that tolerance to patterns of use is discussed. Between-session sensitization of the dopaminergic response to cocaine is reviewed, and data indicating this also occurs in primates have been obtained in self-administering rhesus monkeys, demonstrating neurochemical sensitization in a primate species. The important question of whether cocaine-associated environmental cues elicit conditioned increases in dopamine release has also been examined in the rhesus monkey, with results indicating that, unlike rats, nonhuman primates do not show conditioned increases in dopamine release. JF - The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry AU - Bradberry, Charles W AD - Departments of Psychiatry and Laboratory Medicine, West Haven Veterans Administration Hospital, Yale University School of Medicine, WHVA/116A2, 950 Campbell Avenue, West Haven, CT 06516, USA. charles.bradberry@yale.edu Y1 - 2002/08// PY - 2002 DA - August 2002 SP - 315 EP - 322 VL - 8 IS - 4 SN - 1073-8584, 1073-8584 KW - Dopamine Uptake Inhibitors KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Acute Disease KW - Drug Tolerance KW - Animals KW - Self Administration KW - Extracellular Space -- metabolism KW - Reinforcement (Psychology) KW - Cues KW - Chronic Disease KW - Extracellular Space -- drug effects KW - Cocaine-Related Disorders -- metabolism KW - Conditioning (Psychology) -- drug effects KW - Dopamine -- metabolism KW - Cocaine -- pharmacokinetics KW - Dopamine Uptake Inhibitors -- pharmacokinetics KW - Cocaine -- pharmacology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72027210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Neuroscientist+%3A+a+review+journal+bringing+neurobiology%2C+neurology+and+psychiatry&rft.atitle=Dynamics+of+extracellular+dopamine+in+the+acute+and+chronic+actions+of+cocaine.&rft.au=Bradberry%2C+Charles+W&rft.aulast=Bradberry&rft.aufirst=Charles&rft.date=2002-08-01&rft.volume=8&rft.issue=4&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=The+Neuroscientist+%3A+a+review+journal+bringing+neurobiology%2C+neurology+and+psychiatry&rft.issn=10738584&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-15 N1 - Date created - 2002-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Priapism associated with two atypical antipsychotic agents. AN - 71982008; 12173794 AB - Priapism has been associated with many antipsychotic agents, including clozapine, risperidone, and olanzapine. This prolonged, usually painful, penile erection rarely results from the alpha-adrenergic blocking action of antipsychotics. A 22-year-old African-American man developed priapism during treatment with risperidone and, on a later occasion, during treatment with ziprasidone. The problem resolved only with substitution of other drugs for these antipsychotics. Certain patients may be more vulnerable than others to this adverse effect. Clinicians must be aware of such complications and use caution when prescribing these drugs. JF - Pharmacotherapy AU - Reeves, Roy R AU - Mack, James E AD - G.V. Montgomery VA medical Center, Jackson 39216, USA. roy.reeves@med.va.gov Y1 - 2002/08// PY - 2002 DA - August 2002 SP - 1070 EP - 1073 VL - 22 IS - 8 SN - 0277-0008, 0277-0008 KW - Antipsychotic Agents KW - 0 KW - Piperazines KW - Thiazoles KW - ziprasidone KW - 6UKA5VEJ6X KW - Risperidone KW - L6UH7ZF8HC KW - Index Medicus KW - Humans KW - Adult KW - Chronic Disease KW - Male KW - Piperazines -- therapeutic use KW - Antipsychotic Agents -- therapeutic use KW - Priapism -- chemically induced KW - Schizophrenia -- drug therapy KW - Thiazoles -- adverse effects KW - Risperidone -- adverse effects KW - Piperazines -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Risperidone -- therapeutic use KW - Thiazoles -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71982008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Priapism+associated+with+two+atypical+antipsychotic+agents.&rft.au=Reeves%2C+Roy+R%3BMack%2C+James+E&rft.aulast=Reeves&rft.aufirst=Roy&rft.date=2002-08-01&rft.volume=22&rft.issue=8&rft.spage=1070&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-02-26 N1 - Date created - 2002-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Energetic localization of saxitoxin in its channel binding site. AN - 71914956; 12124273 AB - Saxitoxin (STX) selectively blocks the voltage-gated sodium channel at the outer vestibule lined by P-loops of the four domains. Neosaxitoxin has an additional -OH group at the N1 position of the 1,2,3 guanidinium (N1-OH) that interacts with domains I and IV of the Na(+) channel. Determination of a second toxin interaction with the channel would fix the location of STX. Gonyautoxin 2,3 and Gonyautoxin 1,4 are C-11 sulfated derivatives of saxitoxin and neosaxitoxin, respectively. We used these variants to constrain the STX docking orientation by energetically localizing the C-11 sulfate in the outer vestibule. Interactions between the C-11 sulfate and each of the four domains of the channel were determined by a systematic approach to mutant cycle analysis in which all known carboxyl groups important for site 1 toxin binding were neutralized, allowing energetic triangulation of the toxin sulfate and overcoming some limitations of mutant cycles. Toxin IC(50)s were measured by two-electrode voltage clamp from Xenopus oocytes injected with the channel mRNA. Three unique types of analysis based on the coupling results localized the C-11 sulfate between domains III and IV. Combined with our previous report, the data establish the orientation of STX in the outer vestibule and confirm the clockwise arrangement of the channel domains. JF - Biophysical journal AU - Choudhary, Gaurav AU - Shang, Lisa AU - Li, Xiufeng AU - Dudley, Samuel C AD - Department of Medicine, Emory University and Atlanta Veterans Administration Medical Center, Atlanta, Georgia 30322 USA. Y1 - 2002/08// PY - 2002 DA - August 2002 SP - 912 EP - 919 VL - 83 IS - 2 SN - 0006-3495, 0006-3495 KW - RNA, Messenger KW - 0 KW - Sodium Channels KW - Saxitoxin KW - 35523-89-8 KW - gonyautoxins KW - 77462-64-7 KW - Index Medicus KW - Animals KW - Models, Molecular KW - Electrophysiology KW - Protein Binding KW - Biophysical Phenomena KW - Binding Sites KW - Biophysics KW - RNA, Messenger -- metabolism KW - Oocytes -- metabolism KW - Xenopus KW - Inhibitory Concentration 50 KW - Protein Structure, Tertiary KW - Mutation KW - Protein Conformation KW - Saxitoxin -- analogs & derivatives KW - Saxitoxin -- chemistry KW - Sodium Channels -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71914956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biophysical+journal&rft.atitle=Energetic+localization+of+saxitoxin+in+its+channel+binding+site.&rft.au=Choudhary%2C+Gaurav%3BShang%2C+Lisa%3BLi%2C+Xiufeng%3BDudley%2C+Samuel+C&rft.aulast=Choudhary&rft.aufirst=Gaurav&rft.date=2002-08-01&rft.volume=83&rft.issue=2&rft.spage=912&rft.isbn=&rft.btitle=&rft.title=Biophysical+journal&rft.issn=00063495&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-02-21 N1 - Date created - 2002-07-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biophys J. 1998 Dec;75(6):2647-57 [9826589] Biophys J. 1998 Jul;75(1):236-46 [9649383] J Gen Physiol. 2000 Jan;115(1):81-92 [10613920] Biochemistry. 2000 Jul 18;39(28):8161-70 [10889022] J Gen Physiol. 2000 Nov;116(5):679-90 [11055996] Biophys J. 2001 Feb;80(2):698-706 [11159437] J Biol Chem. 2001 Apr 6;276(14):11072-7 [11154701] Ann N Y Acad Sci. 1986;479:306-12 [3468845] Ann N Y Acad Sci. 1986;479:96-112 [2434011] FEBS Lett. 1991 Nov 18;293(1-2):93-6 [1660007] J Membr Biol. 1994 Jan;137(1):1-8 [7911843] J Mol Biol. 1995 Apr 28;248(2):478-86 [7739054] Biophys J. 1995 Nov;69(5):1657-65 [8580309] Neuron. 1996 May;16(5):1037-47 [8630242] Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7392-6 [8693004] Biophys J. 1996 Dec;71(6):3110-25 [8968582] Biophys J. 1997 Jul;73(1):195-204 [9199784] J Gen Physiol. 1997 Dec;110(6):693-715 [9382897] Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14126-31 [9391164] Biochemistry. 1998 Mar 31;37(13):4407-19 [9521760] Toxicon. 1985;23(4):647-55 [2414863] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Violence and Hostility among Families of Vietnam Veterans with Combat-Related Posttraumatic Stress Disorder AN - 60459605; 200308334 AB - The current study provides a portrait of emotional-behavioral functioning within a small sample of Vietnam veterans with combat-related posttraumatic stress disorder (PTSD), their partners, & older adolescent & adult children. Veterans, their partners & children reported moderate-low to moderate-high levels of violent behavior. In addition, partner & veteran hostility scores were elevated relative to gender & age matched norms. Partners also reported heightened levels of psychological maltreatment by veterans. Veterans' combat exposure was positively correlated with hostility & violent behavior among children but unrelated to partner variables. Veterans' reports of PTSD symptoms were positively associated with reports of hostility & violence among children, & hostility & general psychological distress among partners. Veterans' violent behavior was also positively correlated with children's violent behavior, but did not yield significant correlations with other child or partner variables. Findings are discussed in relation to prior work & directions for future research are addressed. 2 Tables, 56 References. Adapted from the source document. JF - Violence and Victims AU - Glenn, D Michael AU - Beckham, Jean C AU - Feldman, Michelle E AU - Kirby, Angela C AU - Hertzberg, Michael A AU - Moore, Scott D AD - c/o Beckham -- Psychology Service, Durham Veterans Affairs Medical Center, Duke U Medical Center, NC Y1 - 2002/08// PY - 2002 DA - August 2002 SP - 473 EP - 489 VL - 17 IS - 4 SN - 0886-6708, 0886-6708 KW - Veterans KW - Hostility KW - Males KW - Combat KW - Psychological Distress KW - Aggression KW - Posttraumatic Stress Disorder KW - Violence KW - article KW - 2190: social problems and social welfare; victimology (rape, family violence, & child abuse) KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60459605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Violence+and+Victims&rft.atitle=Violence+and+Hostility+among+Families+of+Vietnam+Veterans+with+Combat-Related+Posttraumatic+Stress+Disorder&rft.au=Glenn%2C+D+Michael%3BBeckham%2C+Jean+C%3BFeldman%2C+Michelle+E%3BKirby%2C+Angela+C%3BHertzberg%2C+Michael+A%3BMoore%2C+Scott+D&rft.aulast=Glenn&rft.aufirst=D&rft.date=2002-08-01&rft.volume=17&rft.issue=4&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Violence+and+Victims&rft.issn=08866708&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - VIOVEI N1 - SubjectsTermNotLitGenreText - Posttraumatic Stress Disorder; Veterans; Hostility; Violence; Combat; Psychological Distress; Males; Aggression ER - TY - JOUR T1 - Vancomycin-Resistant Enterococcus faecium Meningitis in a Patient with Underlying Strongyloidiasis AN - 18595799; 5451769 JF - Clinical Microbiology Newsletter AU - Gaydos, J M AU - Polenakovik, H AU - Bernstein, J M AU - Bacheller, C D AU - Oblack, D L AD - Veterans Affairs Medical Center, Department of Pathology and Laboratory, Medicine (113), 10701 East Blvd., Cleveland, OH 44106, USA, vhaclegaydoj@med.va.gov Y1 - 2002/07/15/ PY - 2002 DA - 2002 Jul 15 SP - 109 EP - 111 VL - 24 IS - 14 SN - 0196-4399, 0196-4399 KW - strongyloidiasis KW - Microbiology Abstracts B: Bacteriology KW - J 02848:Nervous system UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18595799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+Newsletter&rft.atitle=Vancomycin-Resistant+Enterococcus+faecium+Meningitis+in+a+Patient+with+Underlying+Strongyloidiasis&rft.au=Gaydos%2C+J+M%3BPolenakovik%2C+H%3BBernstein%2C+J+M%3BBacheller%2C+C+D%3BOblack%2C+D+L&rft.aulast=Gaydos&rft.aufirst=J&rft.date=2002-07-15&rft.volume=24&rft.issue=14&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+Newsletter&rft.issn=01964399&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Effects of voluntary maneuvers on tongue base function for swallowing. AN - 85356383; pmid-12169803 AB - Concurrent manometry and videofluoroscopy were utilized to examine tongue base function during swallowing in 3 patients with head and neck cancer. Subjects were instructed in four voluntary swallow maneuvers, including the supersupraglottic swallow, effortful swallow, Mendelsohn maneuver, and tongue-hold maneuver. Peak catheter pressures (mm Hg) at the tongue base-pharyngeal wall level were recorded and duration of tongue base to pharyngeal wall contact was measured for each swallow. This pilot study revealed that tongue base-pharyngeal wall pressures and contact duration increased with use of maneuvers. Preliminary data are provided to support the use of swallow maneuvers to improve tongue base posterior motion and pressures generated at the tongue base-pharyngeal wall level during swallowing in patients who exhibit this disorder.Copyright 2002 S. Karger AG, Basel JF - Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) AU - Lazarus, Cathy AU - Logemann, Jeri A AU - Song, Chi Wook AU - Rademaker, Alfred W AU - Kahrilas, Peter J AD - Veterans Administration Lakeside Medical Center, Northwestern University Medical School, Chicago, Ill., USA. cathy.lazarus@med.nyu.edu Y1 - 2002/07// PY - 2002 DA - Jul 2002 SP - 171 EP - 176 VL - 54 IS - 4 SN - 1021-7762, 1021-7762 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Carcinoma, Squamous Cell: complications KW - Carcinoma, Squamous Cell: surgery KW - Deglutition Disorders: diagnosis KW - Deglutition Disorders: etiology KW - *Deglutition Disorders: physiopathology KW - Female KW - Fluoroscopy KW - Humans KW - Laryngeal Neoplasms: complications KW - Laryngeal Neoplasms: surgery KW - Male KW - *Tongue: physiopathology KW - Videotape Recording KW - Vocal Cords: surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85356383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Folia+phoniatrica+et+logopaedica+%3A+official+organ+of+the+International+Association+of+Logopedics+and+Phoniatrics+%28IALP%29&rft.atitle=Effects+of+voluntary+maneuvers+on+tongue+base+function+for+swallowing.&rft.au=Lazarus%2C+Cathy%3BLogemann%2C+Jeri+A%3BSong%2C+Chi+Wook%3BRademaker%2C+Alfred+W%3BKahrilas%2C+Peter+J&rft.aulast=Lazarus&rft.aufirst=Cathy&rft.date=2002-07-01&rft.volume=54&rft.issue=4&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Folia+phoniatrica+et+logopaedica+%3A+official+organ+of+the+International+Association+of+Logopedics+and+Phoniatrics+%28IALP%29&rft.issn=10217762&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Acanthamoeba: a rare primary cause of rhinosinusitis. AN - 85354558; pmid-12169899 AB - Parasitic infections, especially Acanthamoeba, are rarely implicated as a specific cause of rhinosinusitis. It is a fatal disease found in the immunocompromised population, in particular in patients infected with the human immunodeficiency virus (HIV). Less than 10 cases of Acanthamebic rhinosinusitis have been reported in the literature, and only 1 has survived. This case report presents an Acanthamebic infection misdiagnosed as a squamous cell carcinoma of the nasal septum on a presumptive healthy, immunocompetent 35-year-old woman. She was later diagnosed with AIDS (AIDS) along with disseminated Acanthamoebiasis and became the second reported case surviving this deadly illness. This case report also discusses the difficulty in diagnosing this rare parasite, the pathogenesis, and the multidisciplinary treatment required to control and manage this uniformly fatal disease. JF - The Laryngoscope AU - Rivera, Miguel A AU - Padhya, Tapan A AD - Department of Otolaryngology Head and Neck Surgery, University of South Florida, Affiliated Hospitals, and The James A. Haley Veterans Administration Hospital, Tampa, Florida, U.S.A. mirivera@hsc.usf.edu Y1 - 2002/07// PY - 2002 DA - Jul 2002 SP - 1201 EP - 1203 VL - 112 IS - 7 Pt 1 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - *Acanthamoeba KW - Adult KW - *Amebiasis KW - Animals KW - Female KW - Humans KW - Rhinitis: complications KW - *Rhinitis: microbiology KW - Sinusitis: complications KW - *Sinusitis: microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85354558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Acanthamoeba%3A+a+rare+primary+cause+of+rhinosinusitis.&rft.au=Rivera%2C+Miguel+A%3BPadhya%2C+Tapan+A&rft.aulast=Rivera&rft.aufirst=Miguel&rft.date=2002-07-01&rft.volume=112&rft.issue=7+Pt+1&rft.spage=1201&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Assessment for addiction in pain-treatment settings. AN - 72763957; 12479252 AB - The identification of the disease of addiction is important to safe and effective clinical management of pain in persons with addictive disorders. The disease of addiction affects approximately 10% of the general population, and its prevalence may be higher in subpopulations of patients with pain. The presence of active addiction may facilitate the experience of pain. Both active and recovering addiction may complicate the use of medications, such as opioids, important to the management of pain. There is, further, persistent misunderstanding among health care providers, regulators, and the general population regarding the nature and manifestations of addiction that may result in undertreatment of pain and stigmatization of patients using opioids for pain control. The author seeks to clarify understanding of addiction, to underscore the importance of identifying addiction in the context of pain treatment, and to provide a rational approach to assessment for addiction in patients with pain. Current scientific understanding of addiction as a chronic illness is briefly reviewed. Recent definitions related to addiction are presented. The impact of addictive disorders on pain and pain treatment are explored. The roles of medical interview, physical examination, laboratory studies, and standard addiction screening tools in assessing for addiction are outlined. Differential considerations in distinguishing therapeutic use of opioids for analgesia from addictive or other nontherapeutic use of opioids are discussed. In summary, the article provides salient background and a detailed approach to assessment for addictive disorders in the context of pain treatment. JF - The Clinical journal of pain AU - Savage, Seddon R AD - Department of Anesthesiology, Dartmouth Medical School, Manchester Veterans Administration Medical Center, New Hampshire Regional Medical Opioid Treatment and Education Project, Bradford, New Hampshire, USA. seddon.savage@dartmouth.edu PY - 2002 SP - S28 EP - S38 VL - 18 IS - 4 Suppl SN - 0749-8047, 0749-8047 KW - Index Medicus KW - Drug Tolerance KW - Pain Clinics KW - Diagnosis, Differential KW - Humans KW - Surveys and Questionnaires KW - Interviews as Topic KW - Chronic Disease KW - Mass Screening -- methods KW - Pain -- complications KW - Pain -- drug therapy KW - Substance-Related Disorders -- etiology KW - Pain -- diagnosis KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72763957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Clinical+journal+of+pain&rft.atitle=Assessment+for+addiction+in+pain-treatment+settings.&rft.au=Savage%2C+Seddon+R&rft.aulast=Savage&rft.aufirst=Seddon&rft.date=2002-07-01&rft.volume=18&rft.issue=4+Suppl&rft.spage=S28&rft.isbn=&rft.btitle=&rft.title=The+Clinical+journal+of+pain&rft.issn=07498047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-30 N1 - Date created - 2002-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tremolite and mesothelioma. AN - 71995042; 12176759 AB - Exposure to chrysotile dust has been associated with the development of mesothelioma and recent studies have implicated contaminating tremolite fibers as the likely etiological factor. Tremolite also contaminates talc, the most common non-asbestos mineral fiber in our control cases. We examined 312 cases of mesothelioma for which fiber burden analyses of lung parenchyma had been performed by means of scanning electron microscopy to determine the content of tremolite, non-commercial amphiboles, talc and chrysotile. The vast majority of these patients were exposed to dust from products containing asbestos. Tremolite was identified in 166 of 312 cases (53%) and was increased above background levels in 81 cases (26%). Fibrous talc was identified in 193 cases (62%) and correlated strongly with the tremolite content (P < 0.0001). Chrysotile was identified in only 32 cases (10%), but still correlated strongly with the tremolite content (P < 0.0001). Talc levels explained less of the tremolite deviance for cases with an increased tremolite level than for cases with a normal range tremolite level (22 versus 42%). In 14 cases (4.5%) non-commercial amphibole fibers (tremolite, actinolite and/or anthophyllite) were the only fiber types found above background. We conclude that tremolite in lung tissue samples from mesothelioma victims derives from both talc and chrysotile and that tremolite accounts for a considerable fraction of the excess fiber burden in end-users of asbestos products. JF - The Annals of occupational hygiene AU - Roggli, Victor L AU - Vollmer, Robin T AU - Butnor, Kelly J AU - Sporn, Thomas A AD - Department of Pathology, Duke University and Durham VA Medical Centers, NC 27710, USA. roggli.v@durham.va.gov Y1 - 2002/07// PY - 2002 DA - July 2002 SP - 447 EP - 453 VL - 46 IS - 5 SN - 0003-4878, 0003-4878 KW - Asbestos, Amphibole KW - 0 KW - tremolite KW - 14567-73-8 KW - Index Medicus KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Female KW - Mesothelioma -- etiology KW - Occupational Diseases -- etiology KW - Occupational Exposure -- analysis KW - Asbestos, Amphibole -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71995042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Tremolite+and+mesothelioma.&rft.au=Roggli%2C+Victor+L%3BVollmer%2C+Robin+T%3BButnor%2C+Kelly+J%3BSporn%2C+Thomas+A&rft.aulast=Roggli&rft.aufirst=Victor&rft.date=2002-07-01&rft.volume=46&rft.issue=5&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-09-18 N1 - Date created - 2002-08-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Women in addictions treatment: comparing VA and community samples. AN - 71937921; 12127467 AB - Despite increasing awareness of gender issues in substance use treatment, women with substance use disorders (SUD) and gender-specific treatment remain understudied. This study examines differences, including identification of comorbid issues and patients' perceived treatment needs, between women in different SUD treatment settings: an intensive VA outpatient program (VA; N = 76) and a private residential/outpatient program (Residence XII; N = 308). In both settings the Addiction Severity Index (ASI) was administered at intake; ASI data were collected from retrospective chart review. Results support previous findings that women entering SUD treatment endorse high rates of psychiatric and medical comorbidity, and past abuse. Women in VA SUD treatment experienced more impairment on indices of medical, psychiatric, and employment issues whereas the private agency sample had higher alcohol and family/social composite scores. The differences between and similarities among the two treatment groups have implications for design of women-specific SUD treatment programs. JF - Journal of substance abuse treatment AU - Davis, Tania M AU - Carpenter, Kelly M AU - Malte, Carol A AU - Carney, Molly AU - Chambers, Sharon AU - Saxon, Andrew J AD - Center of Excellence in Substance Abuse Treatment and Education, VA Puget Sound Health Care System, Seattle Division (S116ATC), 1660 S. Columbian Way, Seattle, WA 98108, USA. tania.davis@med.va.gov Y1 - 2002/07// PY - 2002 DA - July 2002 SP - 41 EP - 48 VL - 23 IS - 1 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Veterans KW - Socioeconomic Factors KW - Severity of Illness Index KW - Outpatients KW - Community Health Centers KW - Sex Factors KW - Mental Disorders -- epidemiology KW - Humans KW - Adult KW - Treatment Outcome KW - Female KW - Comorbidity KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Women's Health KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71937921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Women+in+addictions+treatment%3A+comparing+VA+and+community+samples.&rft.au=Davis%2C+Tania+M%3BCarpenter%2C+Kelly+M%3BMalte%2C+Carol+A%3BCarney%2C+Molly%3BChambers%2C+Sharon%3BSaxon%2C+Andrew+J&rft.aulast=Davis&rft.aufirst=Tania&rft.date=2002-07-01&rft.volume=23&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-16 N1 - Date created - 2002-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Imaging of thoracic occupational and environmental malignancies. AN - 71867729; 12082371 AB - The imaging features of occupational lung cancer are similar to those of nonoccupational cancer. Occupational lung cancer in patients with asbestos exposure must be differentiated from mimics such as round atelectasis and fissural pleural plaques. Mesothelioma remains a largely incurable tumor, though treatment options are expanding. CT, MRI, and PET scanning may all have complementary roles in staging mesothelioma. JF - Journal of thoracic imaging AU - Garg, Kavita AU - Lynch, David A AD - Department of Radiology, Veterans Administration Medical Center, Denver, CO 80262, USA. Y1 - 2002/07// PY - 2002 DA - July 2002 SP - 198 EP - 210 VL - 17 IS - 3 SN - 0883-5993, 0883-5993 KW - Carcinogens, Environmental KW - 0 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Carcinoma, Bronchogenic -- diagnostic imaging KW - Magnetic Resonance Imaging KW - Silicosis -- diagnostic imaging KW - Mortality KW - Diagnosis, Differential KW - Neoplasm Staging KW - Humans KW - Aged KW - Aged, 80 and over KW - Tomography, Emission-Computed KW - Tomography Scanners, X-Ray Computed KW - Middle Aged KW - Radiography KW - Neoplasm Recurrence, Local KW - Male KW - Pulmonary Atelectasis -- diagnostic imaging KW - Occupational Diseases -- diagnostic imaging KW - Carcinogens, Environmental -- adverse effects KW - Mesothelioma -- pathology KW - Asbestos -- adverse effects KW - Mesothelioma -- diagnostic imaging KW - Lung Neoplasms -- diagnostic imaging KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71867729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+thoracic+imaging&rft.atitle=Imaging+of+thoracic+occupational+and+environmental+malignancies.&rft.au=Garg%2C+Kavita%3BLynch%2C+David+A&rft.aulast=Garg&rft.aufirst=Kavita&rft.date=2002-07-01&rft.volume=17&rft.issue=3&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=Journal+of+thoracic+imaging&rft.issn=08835993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-10 N1 - Date created - 2002-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Early hepatitis C viral kinetics correlate with long-term outcome in patients receiving high dose induction followed by combination interferon and ribavirin therapy. AN - 71841862; 12076871 AB - The majority of patients with genotype 1 do not respond to interferon (IFN) plus ribavirin. Limited data exist on the use of induction followed by combination therapy. In this prospective study of 28 patients infected with genotype 1, randomization involved either daily or twice daily high dose IFN for 6 weeks, followed by standard therapy of 3 million units three times a week in combination with ribavirin for an additional 42 weeks. Hepatitis C virus (HCV) RNA was quantitated before and frequently during treatment. The best correlate of response was delta (the infected cell loss rate). Sixteen patients continued on the study because they had at least a 2 log drop in their HCV RNA levels by week 12; all but one were PCR negative for HCV RNA at 48 weeks, and 14 of these 16 patients continued to be PCR negative at 72 weeks. Both African-Americans in our trial failed to respond to therapy, and differences were evident during the induction phase. This randomized study of induction IFN therapy followed by combination IFN plus ribavirin yielded the highest rate of sustained response (50%) reported to date in chronically HCV-infected patients with genotype 1. The predictive value of the infected cell loss rate needs to be evaluated prospectively in larger studies, particularly in patients receiving pegylated IFN. JF - Journal of hepatology AU - Rosen, Hugo R AU - Ribeiro, Ruy R AU - Weinberger, Leor AU - Wolf, Stephanie AU - Chung, Minjun AU - Gretch, David R AU - Perelson, Alan S AD - Division of Gastroenterology and Hepatology, Portland Veterans Affairs Medical Center, Portland, OR 97207, USA. hugo.rosen@med.va.gov Y1 - 2002/07// PY - 2002 DA - July 2002 SP - 124 EP - 130 VL - 37 IS - 1 SN - 0168-8278, 0168-8278 KW - Antiviral Agents KW - 0 KW - RNA, Viral KW - Ribavirin KW - 49717AWG6K KW - Interferons KW - 9008-11-1 KW - Index Medicus KW - Genotype KW - Drug Therapy, Combination KW - Prospective Studies KW - Kinetics KW - Humans KW - Adult KW - Treatment Outcome KW - Male KW - Female KW - RNA, Viral -- blood KW - Antiviral Agents -- administration & dosage KW - Hepatitis C -- drug therapy KW - Hepacivirus -- genetics KW - Interferons -- adverse effects KW - Ribavirin -- administration & dosage KW - Interferons -- administration & dosage KW - Antiviral Agents -- adverse effects KW - Hepacivirus -- growth & development KW - Ribavirin -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71841862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=Early+hepatitis+C+viral+kinetics+correlate+with+long-term+outcome+in+patients+receiving+high+dose+induction+followed+by+combination+interferon+and+ribavirin+therapy.&rft.au=Rosen%2C+Hugo+R%3BRibeiro%2C+Ruy+R%3BWeinberger%2C+Leor%3BWolf%2C+Stephanie%3BChung%2C+Minjun%3BGretch%2C+David+R%3BPerelson%2C+Alan+S&rft.aulast=Rosen&rft.aufirst=Hugo&rft.date=2002-07-01&rft.volume=37&rft.issue=1&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=01688278&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-21 N1 - Date created - 2002-06-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Hepatol. 2002 Jul;37(1):151-3 [12076876] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Myocardial tissue oxygen during coronary artery constriction and hypotension in dogs. AN - 71808259; 12059896 AB - Sodium nitroprusside (SNP) may decrease myocardial tissue oxygenation in dogs with normal coronary arteries. We compared SNP- with desflurane-induced hypotension on myocardial tissue oxygen and pH in dogs with left anterior descending artery constriction. Twenty-four dogs were anesthetized with 8% desflurane for baseline anesthesia. Catheters were inserted into the femoral artery and vein and the coronary sinus. A flow probe and flow restriction device was placed on the left anterior descending (LAD) artery. A probe that measured myocardial oxygen pressure was inserted into the middle myocardium in the LAD region. Baseline measures were made of LAD artery flow, arterial and coronary sinus blood gases, and myocardial tissue gases. A 30% decrease in blood pressure was induced with SNP with unrestricted LAD flow (n=6) or when LAD artery flow was restricted by 30% from baseline (n=6). In separate dogs, a 30% decrease in blood pressure was produced with 14 +/- 1% desflurane with unrestricted LAD flow (n=6) or with baseline LAD artery flow restricted by 30% (n=6). During SNP-induced hypotension with no LAD constriction, LAD artery flow and coronary sinus oxygen tension increased but myocardial tissue oxygen tension (PmO2) decreased by 40%. When baseline artery flow was decreased by 30% by LAD constriction, SNP-induced hypotension decreased tissue oxygen pressure by 80%, and ischemic acidosis was produced. During unrestricted LAD artery flow or with a 30% flow restriction, desflurane-induced hypotension produced no significant change from baseline myocardial tissue oxygen tension or pH. During coronary artery constriction, desflurane-induced hypotension maintained myocardial tissue oxygenation and pH better than did SNP-induced hypotension. The divergence between tissue and coronary sinus oxygen tension during SNP suggests that arteriovenous shunting may occur. JF - Acta anaesthesiologica Scandinavica AU - Hoffman, William E AU - Albrecht, R F AU - Jonjev, Z S AD - Department of Anesthesiology, University of Illinois at Chicago and West Side Veterans Administration, Chicago, IL, USA. whoffman@uic.edu Y1 - 2002/07// PY - 2002 DA - July 2002 SP - 707 EP - 712 VL - 46 IS - 6 SN - 0001-5172, 0001-5172 KW - Anesthetics, Inhalation KW - 0 KW - Vasodilator Agents KW - Nitroprusside KW - 169D1260KM KW - desflurane KW - CRS35BZ94Q KW - Isoflurane KW - CYS9AKD70P KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Animals KW - Heart Rate -- drug effects KW - Blood Pressure -- physiology KW - Oxygen Consumption -- physiology KW - Dogs KW - Blood Gas Analysis KW - Coronary Stenosis KW - Male KW - Hypotension -- chemically induced KW - Anesthetics, Inhalation -- pharmacology KW - Oxygen -- physiology KW - Hypotension -- pathology KW - Nitroprusside -- pharmacology KW - Isoflurane -- analogs & derivatives KW - Isoflurane -- pharmacology KW - Myocardium -- metabolism KW - Vasodilator Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71808259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+anaesthesiologica+Scandinavica&rft.atitle=Myocardial+tissue+oxygen+during+coronary+artery+constriction+and+hypotension+in+dogs.&rft.au=Hoffman%2C+William+E%3BAlbrecht%2C+R+F%3BJonjev%2C+Z+S&rft.aulast=Hoffman&rft.aufirst=William&rft.date=2002-07-01&rft.volume=46&rft.issue=6&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Acta+anaesthesiologica+Scandinavica&rft.issn=00015172&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-16 N1 - Date created - 2002-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A Trial of "Standard" Outpatient Alcoholism Treatment vs. a Minimal Treatment Control AN - 61498301; 200301816 AB - This study sought to examine the effectiveness of a "standard" outpatient alcoholism treatment (ST) program. An outpatient alcoholism treatment as it is commonly practiced in the US (with group & individual therapy, & an emphasis on Alcoholics Anonymous [AA]), was compared with a minimal treatment (MT) approach (weekly alcohol education movies). At 6 months, ST patients surpassed those in MT in terms of complete abstinence, reduction in amount of alcohol consumed, length of sobriety at follow-up, improvement in employment status, number of AA meetings attended, & lower initial dropout. It is concluded that a ST approach is more helpful than MT in treating severely alcohol-dependent individuals who have not been able to cut down drinking on their own. Those already drinking less appeared to be helped by MT. 8 Tables, 23 References. Adapted from the source document. JF - Journal of Substance Abuse Treatment AU - Davis, William T AU - Campbell, Larry AU - Tax, Judith AU - Lieber, Charles S AD - Dept Veterans Affairs Medical Center, Bronx, NY william.davis2@med.va.gov Y1 - 2002/07// PY - 2002 DA - July 2002 SP - 9 EP - 19 VL - 23 IS - 1 SN - 0740-5472, 0740-5472 KW - Outpatients KW - New York City, New York KW - Treatment Outcomes KW - Treatment Programs KW - Alcoholism KW - Self Help Groups KW - Treatment Methods KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61498301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=A+Trial+of+%22Standard%22+Outpatient+Alcoholism+Treatment+vs.+a+Minimal+Treatment+Control&rft.au=Davis%2C+William+T%3BCampbell%2C+Larry%3BTax%2C+Judith%3BLieber%2C+Charles+S&rft.aulast=Davis&rft.aufirst=William&rft.date=2002-07-01&rft.volume=23&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Alcoholism; Treatment Programs; Treatment Outcomes; Outpatients; Treatment Methods; New York City, New York; Self Help Groups ER - TY - JOUR T1 - THE ISOLATION OF AN IMMORTALIZED AND TUMORIGENIC CELL LINE FROM p21WAF1 NULL MOUSE BLADDERS AN - 19332607; 8696211 AB - Given a role for the deregulation of p21WAF1 in the progression of bladder tumors, we examined the growth of cultured urothelial cells from wild-type and p21WAF1 null bladders. Bladders were excised, minced from euthanized p21WAF1 and wild-type mice, treated overnight with dispase, and then placed into flasks coated with collagen type I in Dulbecco modified Eagle medium with 10% fetal calf serum. After an overnight incubation, the media was replaced with a serum-free media and a portion of explants were treated with 12-O-tetrade-canoylphorbol-13-acetate (TPA) on day 7 and continued for either 4 or 9 wk. The urothelial origin of any surviving epithelial cells was determined by reverse transcription-polymerase chain reaction (RT-PCR) using uroplakin II-specific primers, and the expression of the cell cycle-related proteins, p16INK4 and p19ARF, was examined by semiquantitative RT-PCR and Western blotting. Isolated wild-type and serially passaged p21WAF1 null epithelial-like cells were then injected subcutaneously into nude mice. We found that phorbol ester treatment at two different concentrations significantly enhanced uroepithelial colony formation from isolated wild-type mouse bladder tissue. On the other hand, significantly fewer urothelial colonies were derived from p21WAF1 null bladder cells treated with phorbol ester. Although there was apparent senescence and cell death of epithelial foci and stromal cells in phorbol ester-treated and -untreated p21WAF1 null cultures, after 3 mo there was an apparent subpopulation of epitheloid cells that overgrew each flask. There was a significant decrease in the number of these serially passaged cells in the G1 phase of the cell cycle when compared with initial explant wild-type or p21WAF1 null cells. This subpopulation of epitheloid cells expressed the mouse uroplakin II gene, indicating a urothelial phenotype, but did not express either the p16INKa or p19ARF proteins, whereas p21WAF1 null bladders express both proteins. There was also a high level of expression of the p53 protein and a significant decrease in the expression of the p19ARF transcript in both p21WAF1 null bladder and p21WAF1 null cells. These p21WAF1 null cells could be easily passaged and when injected subcutaneously into nude mice, large tumors developed. Therefore, it appears that a subpopulation of urothelial cells from the p21WAF1 null bladder can develop a tumorigenic phenotype in vitro. JF - In Vitro Cellular & Developmental Biology - Animal AU - McGarvey, Terence W AU - Nguyen, Trang B AU - Tomaszewski, John E AU - MALKOWICZ, SBRUCE AD - Division of Urology (T. W. M., S. B. M.) and Department of Pathology and Laboratory Medicine (J. E. T.), Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, and Veterans Administration Medical Center (T. W. M., T. B. N., S. B. M.), Philadelphia, Pennsylvania 19104 Y1 - 2002/07// PY - 2002 DA - Jul 2002 SP - 394 EP - 400 PB - Allen Press, Inc., 810 East Tenth St. VL - 38 IS - 7 SN - 1071-2690, 1071-2690 KW - Biotechnology and Bioengineering Abstracts KW - p21WAF1 gene KW - tumorigenesis KW - immortalization KW - bladder KW - Epithelial cells KW - Phorbol esters KW - stromal cells KW - Cell cycle KW - Cell culture KW - TPA KW - Colonies KW - Polymerase chain reaction KW - Collagen (type I) KW - Media (isolation) KW - Western blotting KW - Urinary bladder KW - Fetal calf serum KW - Null cells KW - Transcription KW - Tumors KW - p53 protein KW - Cell death KW - p19ARF protein KW - G1 phase KW - Senescence KW - Primers KW - Cyclin-dependent kinase inhibitor p21 KW - Explants KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19332607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.atitle=THE+ISOLATION+OF+AN+IMMORTALIZED+AND+TUMORIGENIC+CELL+LINE+FROM+p21WAF1+NULL+MOUSE+BLADDERS&rft.au=McGarvey%2C+Terence+W%3BNguyen%2C+Trang+B%3BTomaszewski%2C+John+E%3BMALKOWICZ%2C+SBRUCE&rft.aulast=McGarvey&rft.aufirst=Terence&rft.date=2002-07-01&rft.volume=38&rft.issue=7&rft.spage=394&rft.isbn=&rft.btitle=&rft.title=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.issn=10712690&rft_id=info:doi/10.1290%2F1071-2690%282002%290382.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Western blotting; Phorbol esters; stromal cells; Urinary bladder; Fetal calf serum; Cell cycle; Null cells; Transcription; Cell culture; Tumors; TPA; p53 protein; Cell death; Colonies; p19ARF protein; G1 phase; Polymerase chain reaction; Primers; Senescence; Cyclin-dependent kinase inhibitor p21; Collagen (type I); Explants; Media (isolation) DO - http://dx.doi.org/10.1290/1071-2690(2002)038<0394:TIOAIA>2.0.CO;2 ER - TY - JOUR T1 - Sildenafil for male erectile dysfunction: a systematic review and meta-analysis. AN - 71844971; 12076233 AB - To determine the efficacy and safety of sildenafil citrate in the treatment of male erectile dysfunction. The MEDLINE, HealthSTAR, Current Contents, and Cochrane Library databases (January 1, 1995, through December 31, 2000); bibliographies of retrieved articles and review articles; conference proceedings abstracts; the Food and Drug Administration Web site; and the manufacturer. Trials were eligible if they included men with erectile dysfunction, compared sildenafil with control, were randomized, were of at least 7 days' duration, and assessed clinically relevant outcomes. Two reviewers independently evaluated study quality and extracted data in a standardized fashion. Twenty-seven trials (6659 men) met the inclusion criteria. In results pooled from 14 parallel-group, flexible as-needed dosing trials, sildenafil was more likely than placebo to lead to successful sexual intercourse, with a higher percentage of successful intercourse attempts (57% vs 21%; weighted mean difference, 33.7; 95% confidence interval [CI], 29.2-38.2; 2283 men) and a greater percentage of men experiencing at least 1 intercourse success during treatment (83% vs 45%; relative benefit increase, 1.8; 95% CI, 1.7-1.9; 2205 men). In data pooled from 6 parallel-group, fixed-dose trials, efficacy appeared slightly greater at higher doses. Treatment response appeared to vary between patient subgroups, although relative to placebo, sildenafil significantly improved erectile function in all evaluated subgroups. In trials with parallel-group design and flexible dosing, men randomized to receive sildenafil were less likely than those receiving placebo to drop out for any reason and no more likely to drop out due to an adverse event or laboratory abnormality. Specific adverse events with sildenafil included flushing (12%), headache (11%), dyspepsia (5%), and visual disturbances (3%); all adverse events were significantly less likely to occur with placebo. Sildenafil was not significantly associated with serious cardiovascular events or death. Sildenafil improves erectile function and is generally well tolerated. Treatment response seems to vary between patient subgroups, although sildenafil has greater efficacy than placebo in all evaluated subgroups. JF - Archives of internal medicine AU - Fink, Howard A AU - Mac Donald, Roderick AU - Rutks, Indulis R AU - Nelson, David B AU - Wilt, Timothy J AD - Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center, 1 Veterans Dr, PO Box 11G, Minneapolis, MN 55417, USA. howard.fink@med.va.gov Y1 - 2002/06/24/ PY - 2002 DA - 2002 Jun 24 SP - 1349 EP - 1360 VL - 162 IS - 12 SN - 0003-9926, 0003-9926 KW - Phosphodiesterase Inhibitors KW - 0 KW - Piperazines KW - Purines KW - Sulfones KW - Vasodilator Agents KW - Sildenafil Citrate KW - BW9B0ZE037 KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Age Factors KW - Patient Satisfaction KW - Dose-Response Relationship, Drug KW - Humans KW - Aged KW - Dyspepsia -- etiology KW - Sexual Behavior KW - Flushing -- etiology KW - Vision Disorders -- etiology KW - Middle Aged KW - Headache -- etiology KW - Male KW - Phosphodiesterase Inhibitors -- administration & dosage KW - Piperazines -- therapeutic use KW - Erectile Dysfunction -- drug therapy KW - Vasodilator Agents -- adverse effects KW - Vasodilator Agents -- administration & dosage KW - Erectile Dysfunction -- ethnology KW - Vasodilator Agents -- therapeutic use KW - Piperazines -- adverse effects KW - Penile Erection -- drug effects KW - Erectile Dysfunction -- etiology KW - Piperazines -- administration & dosage KW - Phosphodiesterase Inhibitors -- therapeutic use KW - Phosphodiesterase Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71844971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=Sildenafil+for+male+erectile+dysfunction%3A+a+systematic+review+and+meta-analysis.&rft.au=Fink%2C+Howard+A%3BMac+Donald%2C+Roderick%3BRutks%2C+Indulis+R%3BNelson%2C+David+B%3BWilt%2C+Timothy+J&rft.aulast=Fink&rft.aufirst=Howard&rft.date=2002-06-24&rft.volume=162&rft.issue=12&rft.spage=1349&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-12 N1 - Date created - 2002-06-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: ACP J Club. 2003 Jan-Feb;138(1):5 [12511117] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Specific up-regulation of GADD153/CHOP in 1-methyl-4-phenyl-pyridinium-treated SH-SY5Y cells. AN - 71893459; 12111836 AB - Growth arrest DNA damage-inducible 153 (GADD153) expression was increased in 1-methyl-4-phenyl-pyridinium (MPP(+))-treated human SH-SY5Y neuroblastoma cells as determined by gene microarray analysis. GADD153 expression increased after 24 hr of MPP(+) (1 mM) exposure and preceded activation of caspase 3. Comparison of GADD153 expression among cultures treated with other toxins whose primary mode of action is either via mitochondrial impairment (rotenone) or via oxidative stress (6-hydroxydopamine or hydrogen peroxide) showed that GADD153 was uniquely up-regulated by MPP(+). Together these data suggest that a cellular mechanism distinct from mitochondrial impairment or oxidative stress contributes significantly to the up-regulation of GADD153 by MPP(+) and that GADD153 may function as an inducer of apoptosis following MPP(+) exposure. Published 2002 Wiley-Liss, Inc. JF - Journal of neuroscience research AU - Conn, Kelly J AU - Gao, Wen-Wu AU - Ullman, M David AU - McKeon-O'Malley, Catherine AU - Eisenhauer, Patricia B AU - Fine, Richard E AU - Wells, John M AD - Department of Veterans Affairs, VA Medical Center, Bedford, Massachusetts 01730, USA. conn.kelly_j@bedford.va.gov Y1 - 2002/06/15/ PY - 2002 DA - 2002 Jun 15 SP - 755 EP - 760 VL - 68 IS - 6 SN - 0360-4012, 0360-4012 KW - Adrenergic Agents KW - 0 KW - CCAAT-Enhancer-Binding Proteins KW - DDIT3 protein, human KW - Herbicides KW - Insecticides KW - Oxidants KW - RNA, Messenger KW - Transcription Factors KW - Rotenone KW - 03L9OT429T KW - Transcription Factor CHOP KW - 147336-12-7 KW - Oxidopamine KW - 8HW4YBZ748 KW - Hydrogen Peroxide KW - BBX060AN9V KW - CASP3 protein, human KW - EC 3.4.22.- KW - Caspase 3 KW - Caspases KW - 1-Methyl-4-phenylpyridinium KW - R865A5OY8J KW - Index Medicus KW - Insecticides -- toxicity KW - Oxidants -- pharmacology KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Hydrogen Peroxide -- pharmacology KW - RNA, Messenger -- analysis KW - Rotenone -- pharmacology KW - Neuroblastoma KW - Oxidopamine -- pharmacology KW - Adrenergic Agents -- pharmacology KW - Adrenergic Agents -- toxicity KW - Hydrogen Peroxide -- toxicity KW - Rotenone -- toxicity KW - Polymerase Chain Reaction KW - Blotting, Western KW - Tumor Cells, Cultured KW - Oxidopamine -- toxicity KW - Oxidants -- toxicity KW - Enzyme Activation -- drug effects KW - Up-Regulation KW - Insecticides -- pharmacology KW - Herbicides -- pharmacology KW - 1-Methyl-4-phenylpyridinium -- toxicity KW - Transcription Factors -- analysis KW - Herbicides -- toxicity KW - CCAAT-Enhancer-Binding Proteins -- analysis KW - CCAAT-Enhancer-Binding Proteins -- genetics KW - Transcription Factors -- genetics KW - Caspases -- metabolism KW - 1-Methyl-4-phenylpyridinium -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71893459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+research&rft.atitle=Specific+up-regulation+of+GADD153%2FCHOP+in+1-methyl-4-phenyl-pyridinium-treated+SH-SY5Y+cells.&rft.au=Conn%2C+Kelly+J%3BGao%2C+Wen-Wu%3BUllman%2C+M+David%3BMcKeon-O%27Malley%2C+Catherine%3BEisenhauer%2C+Patricia+B%3BFine%2C+Richard+E%3BWells%2C+John+M&rft.aulast=Conn&rft.aufirst=Kelly&rft.date=2002-06-15&rft.volume=68&rft.issue=6&rft.spage=755&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+research&rft.issn=03604012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-08-14 N1 - Date created - 2002-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Serotonin syndrome and linezolid. AN - 71721351; 12032904 AB - We present a case of serotonin syndrome in a patient who initiated linezolid therapy shortly after discontinuation of therapy with a selective serotonin reuptake inhibitor (paroxetine). JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Wigen, Christine L AU - Goetz, Matthew B AD - Infectious Diseases Section, Department of Medicine, Veterans Administration Greater Los Angeles Healthcare System and University of California Los Angeles School of Medicine, Los Angeles, CA, USA. Y1 - 2002/06/15/ PY - 2002 DA - 2002 Jun 15 SP - 1651 EP - 1652 VL - 34 IS - 12 KW - Acetamides KW - 0 KW - Anti-Infective Agents KW - Oxazolidinones KW - Serotonin Uptake Inhibitors KW - Linezolid KW - ISQ9I6J12J KW - Index Medicus KW - Drug Interactions KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Humans KW - Middle Aged KW - Female KW - Anti-Infective Agents -- adverse effects KW - Oxazolidinones -- adverse effects KW - Serotonin Syndrome -- chemically induced KW - Acetamides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71721351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Serotonin+syndrome+and+linezolid.&rft.au=Wigen%2C+Christine+L%3BGoetz%2C+Matthew+B&rft.aulast=Wigen&rft.aufirst=Christine&rft.date=2002-06-15&rft.volume=34&rft.issue=12&rft.spage=1651&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-20 N1 - Date created - 2002-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Protection from Streptococcus pneumoniae Infection by C-Reactive Protein and Natural Antibody Requires Complement But Not Fc gamma Receptors AN - 18422993; 5401294 AB - Streptococcus pneumoniae is an important human pathogen and the most common cause of community-acquired pneumonia. Both adaptive and innate immune mechanisms provide protection from infection. Innate immunity to S. pneumoniae in mice is mediated by naturally occurring anti-phosphocholine (PC) Abs and complement. The human acute-phase reactant C-reactive protein (CRP) also protects mice from lethal S. pneumoniae infection. CRP and anti-PC Ab share the ability to bind to PC on the cell wall C-polysaccharide of S. pneumoniae and to activate complement. CRP and IgG anti-PC also bind to Fc gamma R. In this study, Fc gamma R- and complement-deficient mice were used to compare the mechanisms of protection conferred by CRP and anti-PC Ab. Injection of CRP protected wild-type, FcR gamma -chain-, Fc gamma RIIb-, and Fc gamma RIII-deficient mice from infection. Complement was required for the protective effect of CRP as cobra venom factor treatment eliminated the effect of CRP in both gamma -chain-deficient and wild-type mice, and CRP failed to protect C3- or C4-deficient mice from infection. Unexpectedly, gamma -chain-deficient mice were extremely sensitive to pneumococcal infection. This sensitivity was associated with low levels of natural anti-PC Ab. gamma -chain-deficient mice immunized with nonencapsulated S. pneumoniae produced both IgM- and IgG PC-specific Abs, were protected from infection, and were able to clear the bacteria from the bloodstream. The protection provided by immunization was eliminated by complement depletion. The results show that in this model of systemic infection with highly virulent S. pneumoniae, protection from lethality by CRP and anti-PC Abs requires complement, but not Fc gamma R. JF - Journal of Immunology AU - Mold, C AU - Rodic-Polic, B AU - Clos, TWD AD - Departments of Molecular Genetics and Microbiology and Internal Medicine, School of Medicine, University of New Mexico, and U.S. Department of Veterans Affairs Medical Center, Albuquerque, NM 87108 Y1 - 2002/06/15/ PY - 2002 DA - 2002 Jun 15 SP - 6375 EP - 6381 VL - 168 IS - 12 SN - 0022-1767, 0022-1767 KW - double prime C-reactive protein KW - double prime Fc receptors KW - c-reactive protein KW - mice KW - phosphocholine KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - F 06801:Bacteria KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18422993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Protection+from+Streptococcus+pneumoniae+Infection+by+C-Reactive+Protein+and+Natural+Antibody+Requires+Complement+But+Not+Fc+gamma+Receptors&rft.au=Mold%2C+C%3BRodic-Polic%2C+B%3BClos%2C+TWD&rft.aulast=Mold&rft.aufirst=C&rft.date=2002-06-15&rft.volume=168&rft.issue=12&rft.spage=6375&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Organization of the membrane domain of the human liver sodium/bile acid cotransporter. AN - 71783002; 12044156 AB - Mammalian sodium/bile acid cotransporters (SBATs) are glycoproteins with an exoplasmic N-terminus, an odd number of transmembrane regions, and a cytoplasmic C-terminus. Various algorithms predict eight or nine membrane-embedded regions derived from nine hydrophobic stretches of the protein (H1-H9). Three methods were used to define which of these were transmembrane or membrane-associated segments in the liver bile acid transporter. The first was in vitro translation/insertion scanning using either single hydrophobic sequences between the N-terminal domain of the alpha-subunit of the gastric H,K-ATPase and the C-terminal domain of the beta-subunit that contains five N-linked glycosylation exoplasmic flags or using constructs beginning with the N-terminus of the transporter of various lengths and again ending in the C-terminus of the H,K-ATPase beta-subunit. Seven of the predicted segments, but not the amphipathic H3 and H8 sequences, insert as both individual signal anchor and stop transfer sequences in the reporter constructs. These sequences, H3 and H8, are contained within two postulated long exoplasmic loops in the classical seven-transmembrane segment model. The H3 segment acts as a partial stop transfer signal when expressed downstream of the endogenous H2. In a similar manner, the other amphipathic segment, H8, inserts as a signal anchor sequence when translated in the context with the upstream transporter sequence in two different glycosylation constructs. Alanine insertion scanning identified regions of the transporter requiring precise alignment of sequence to form competent secondary structures. The transport activity of these mutants was evaluated either in native protein or in a yellow fluorescent protein (YFP) fusion protein construct. All alanine insertions in H3 and H8 abolished taurocholate uptake, suggesting that both these regions have structures with critical intramolecular interactions. Moreover, these insertions also prevented trafficking to the plasma membrane as assessed by confocal microscopy with a polyclonal antibody against either the C-terminus of the transporter or the YFP signal of the YFP-transporter fusion protein. Two glycosylation signals inserted in the first postulated loop region and four of five such signals in the second postulated loop region were not recognized by the oligosaccharide transferase, and the L256N mutation exhibited 10% glycosylation and was inactive. These findings support a topography with nine membrane-spanning or membrane-associated segments. JF - Biochemistry AU - Hallén, S AU - Mareninova, O AU - Brändén, M AU - Sachs, G AD - Wadsworth Veterans Administration Hospital, West Los Angeles VA Medical Center, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA. Y1 - 2002/06/11/ PY - 2002 DA - 2002 Jun 11 SP - 7253 EP - 7266 VL - 41 IS - 23 SN - 0006-2960, 0006-2960 KW - Bacterial Proteins KW - 0 KW - Bile Acids and Salts KW - Carrier Proteins KW - Luminescent Proteins KW - Membrane Glycoproteins KW - Organic Anion Transporters, Sodium-Dependent KW - Peptide Fragments KW - Recombinant Fusion Proteins KW - Symporters KW - yellow fluorescent protein, Bacteria KW - sodium-bile acid cotransporter KW - 145420-23-1 KW - Sodium KW - 9NEZ333N27 KW - Index Medicus KW - Microscopy, Confocal KW - Hydrophobic and Hydrophilic Interactions KW - Bacterial Proteins -- genetics KW - Genetic Vectors -- chemical synthesis KW - Humans KW - Amino Acid Sequence KW - Glycosylation KW - Genetic Vectors -- metabolism KW - Recombinant Fusion Proteins -- metabolism KW - Mutagenesis, Site-Directed KW - Protein Structure, Tertiary -- genetics KW - Protein Transport -- genetics KW - Molecular Sequence Data KW - Luminescent Proteins -- genetics KW - Cell Line KW - Recombinant Fusion Proteins -- chemical synthesis KW - Peptide Fragments -- metabolism KW - Membrane Glycoproteins -- chemistry KW - Carrier Proteins -- metabolism KW - Carrier Proteins -- chemistry KW - Peptide Fragments -- genetics KW - Carrier Proteins -- genetics KW - Liver -- metabolism KW - Bile Acids and Salts -- metabolism KW - Liver -- chemistry KW - Peptide Fragments -- chemistry KW - Sodium -- metabolism KW - Membrane Glycoproteins -- genetics KW - Membrane Glycoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71783002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Organization+of+the+membrane+domain+of+the+human+liver+sodium%2Fbile+acid+cotransporter.&rft.au=Hall%C3%A9n%2C+S%3BMareninova%2C+O%3BBr%C3%A4nd%C3%A9n%2C+M%3BSachs%2C+G&rft.aulast=Hall%C3%A9n&rft.aufirst=S&rft.date=2002-06-11&rft.volume=41&rft.issue=23&rft.spage=7253&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-19 N1 - Date created - 2002-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cortical representation of swallowing: a modified dual task paradigm. AN - 85373410; pmid-12081263 AB - It is unclear whether the cortical representation of swallowing is lateralized to the left cerebral hemisphere, right hemisphere, or bilaterally represented. As dysphagia is common in acute stroke, it is important to elucidate swallowing lateralization to facilitate earlier detection of stroke patients who may be at greater risk for dysphagia and aspiration. In this study, a modified dual task paradigm was designed to study laterality of swallowing in a group of 14 healthy, young, right-handed, male adults. The subjects were studied at baseline and with interference. Baseline conditions, performed separately, were continuous swallowing, finger tapping using the right and left index fingers, and word repetition. Interference tasks, including tapping with the right index finger, tapping with the left index finger, and word repetition, were completed with and without swallowing. Finger-tapping rate was measured, and x-ray samples of the swallowing task were taped to measure swallowing rate and volume swallowed. At baseline, the rate of tapping the right index finger was significantly faster than that of the left index finger. There was a significant decline in the tapping rates of both left and right index fingers with swallowing interference. The volume per swallow was significantly reduced during the interfering language task of silent repetition. These results offer partial support for a bilateral representation of swallowing as well as suggest an important left hemispheric contribution to swallowing. However, it cannot be concluded that the left hemisphere is more important than the right, as a comparable right hemisphere task was not studied. JF - Perceptual and motor skills AU - Daniels, Stephanie K AU - Corey, David M AU - Barnes, Cristen L AU - Faucheaux, Nikki M AU - Priestly, Daniel H AU - Foundas, Anne L AD - Department of Veterans Affairs Medical Center, Tulane University School of Medicine, USA. stephanie.daniels@med.va.gov Y1 - 2002/06// PY - 2002 DA - Jun 2002 SP - 1029 EP - 1040 VL - 94 IS - 3 Pt 1 SN - 0031-5125, 0031-5125 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Attention: physiology KW - *Cerebral Cortex: physiology KW - *Deglutition: physiology KW - *Dominance, Cerebral: physiology KW - Functional Laterality: physiology KW - Humans KW - Male KW - Mental Recall: physiology KW - Motor Activity: physiology KW - Neuropsychological Tests KW - Reference Values KW - Verbal Learning: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85373410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+motor+skills&rft.atitle=Cortical+representation+of+swallowing%3A+a+modified+dual+task+paradigm.&rft.au=Daniels%2C+Stephanie+K%3BCorey%2C+David+M%3BBarnes%2C+Cristen+L%3BFaucheaux%2C+Nikki+M%3BPriestly%2C+Daniel+H%3BFoundas%2C+Anne+L&rft.aulast=Daniels&rft.aufirst=Stephanie&rft.date=2002-06-01&rft.volume=94&rft.issue=3+Pt+1&rft.spage=1029&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+motor+skills&rft.issn=00315125&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Lexical and talker effects on word recognition among native and non-native listeners with normal and impaired hearing. AN - 85372735; pmid-12069010 AB - Evidence suggests that word recognition depends on numerous talker-, listener-, and stimulus-related characteristics. The current study examined the effects of talker variability and lexical difficulty on spoken-word recognition among four groups of listeners: native listeners with normal hearing or hearing impairment (moderate sensorineural hearing loss) and non-native listeners with normal hearing or hearing impairment. The ability of listeners to accommodate trial-to-trial variations in talkers' voice was assessed by comparing recognition scores for a single-talker condition to those obtained in a multiple-talker condition. Lexical difficulty was assessed by comparing word-recognition performance between lexically "easy" and "hard" words as determined by frequency of occurrence in language and the structural characteristics of similarity neighborhoods formalized in the Neighborhood Activation Model. An up-down adaptive procedure was used to determine the sound pressure level for 50% performance. Non-native listeners in both normal-hearing and hearing-impaired groups required greater intensity for equal intelligibility than the native normal-hearing and hearing-impaired listeners. Results, however, showed significant effects of talker variability and lexical difficulty for the four groups. Structural equation modeling demonstrated that an audibility factor accounts for 2-3 times more variance in performance than does a linguistic-familiarity factor. However, the linguistic-familiarity factor is also essential to the model fit. The results demonstrated effects of talker variability and lexical difficulty on word recognition for both native and nonnative listeners with normal or impaired hearing. The results indicate that linguistic and indexical factors should be considered in the development of speech-recognition tests. JF - Journal of speech, language, and hearing research : JSLHR AU - Takayanagi, Sumiko AU - Dirks, Donald D AU - Moshfegh, Anahita AD - National Center for Rehabilitative Auditory Research, Veterans Administration Medical Center, Portland, OR, USA. stakayanagi@mailhouse.hei.org Y1 - 2002/06// PY - 2002 DA - Jun 2002 SP - 585 EP - 597 VL - 45 IS - 3 SN - 1092-4388, 1092-4388 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Audiometry, Pure-Tone KW - Female KW - *Hearing Loss, Sensorineural: diagnosis KW - Hearing Loss, Sensorineural: epidemiology KW - Humans KW - *Language KW - Male KW - *Recognition (Psychology) KW - *Speech Perception: physiology KW - *Vocabulary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85372735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.atitle=Lexical+and+talker+effects+on+word+recognition+among+native+and+non-native+listeners+with+normal+and+impaired+hearing.&rft.au=Takayanagi%2C+Sumiko%3BDirks%2C+Donald+D%3BMoshfegh%2C+Anahita&rft.aulast=Takayanagi&rft.aufirst=Sumiko&rft.date=2002-06-01&rft.volume=45&rft.issue=3&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.issn=10924388&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Immunological responses are not abnormal in symptomatic Gulf War veterans. AN - 71886536; 12114290 AB - The underlying etiology and pathogenesis of Gulf War veterans' illnesses continue to be under intense investigation. Reports have suggested the basis for these illnesses may be an altered immune system, but compelling evidence is lacking. We sought to determine whether in vitro immune responses were abnormal in symptomatic Gulf War veterans relative to matched controls. A randomized case-control study was conducted by blinded comparison of laboratory measures of in vitro immune responses in blood samples obtained from veterans in an outpatient facility of a Veterans Affairs medical center. Symptomatic Gulf War veterans with otherwise undefined illnesses (52 symptomatic subjects), asymptomatic Gulf War veterans (31 asymptomatic controls), and veterans who had applied for disability compensation and had not participated in the Gulf War (21 disability controls) represented the volunteer sample. In vitro cellular and humoral immune responses were measured to detect functional abnormalities in antigen presenting cells (autologous mixed leukocyte reactions and expression of interleukin (IL)-1beta, IL-6, IL-10, and tumor necrosis factor-alpha); T cells (lymphocyte proliferation using the polyclonal T-cell activators phytohemagglutinin and Concanavalin A; primary immune responses in allogeneic mixed leukocyte reactions; secondary immune response using the recall antigens tetanus toxoid, Candida albicans, and anthrax vaccine; and soluble IL-2 receptor expression); type-1 T-helper cells (gamma interferon expression); type-2 T-helper cells (IL-4 and IL-10 expression); and B cells (polyclonal B-cell activator pokeweed mitogen-induced immunoglobulin production). In general, immune response measures did not differ significantly between groups. Heightened responses observed in the disability control group (sporadically greater responses to one mitogen and two antigens) and the Gulf War participation control group (greater recall responses to anthrax vaccine) did not suggest impaired immune cell function in symptomatic veterans when compared with controls. We conclude that in vitro immunological responses are not abnormal in symptomatic Gulf War veterans. JF - Annals of the New York Academy of Sciences AU - Everson, Michael P AU - Shi, Ke AU - Aldridge, Peggy AU - Bartolucci, Alfred A AU - Blackburn, Warren D AD - Department of Veterans Affairs Medical Center, Birmingham, Alabama 35233, USA. michael.everson@med.va.gov Y1 - 2002/06// PY - 2002 DA - June 2002 SP - 327 EP - 342 VL - 966 SN - 0077-8923, 0077-8923 KW - Cytokines KW - 0 KW - Phytohemagglutinins KW - Concanavalin A KW - 11028-71-0 KW - Index Medicus KW - Random Allocation KW - Cytokines -- biosynthesis KW - Humans KW - Lymphocyte Culture Test, Mixed KW - Antibody Formation KW - Phytohemagglutinins -- pharmacology KW - Veterans KW - Lymphocyte Activation -- drug effects KW - Alabama -- epidemiology KW - Immunity, Cellular KW - Single-Blind Method KW - Cells, Cultured KW - Immunologic Tests KW - Veterans Disability Claims KW - Adult KW - Case-Control Studies KW - Immunologic Memory KW - Lymphocyte Subsets -- immunology KW - Middle Aged KW - Male KW - Concanavalin A -- pharmacology KW - Female KW - Persian Gulf Syndrome -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71886536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Immunological+responses+are+not+abnormal+in+symptomatic+Gulf+War+veterans.&rft.au=Everson%2C+Michael+P%3BShi%2C+Ke%3BAldridge%2C+Peggy%3BBartolucci%2C+Alfred+A%3BBlackburn%2C+Warren+D&rft.aulast=Everson&rft.aufirst=Michael&rft.date=2002-06-01&rft.volume=966&rft.issue=&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-08-15 N1 - Date created - 2002-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The antibiotic treatment trial of Gulf War Veterans' Illnesses: issues, design, screening, and baseline characteristics. AN - 71806047; 12057884 AB - Many veterans who were deployed to the Persian Gulf during the 1990-1991 Gulf War developed multiple unexplained symptoms such as pain, fatigue, and neurocognitive problems. This constellation of symptoms has been termed Gulf War Veterans' Illnesses (GWVI). Although there is no proven explanation for the cause of GWVI, one fairly widespread explanation is systemic Mycoplasma fermentans infection. The Antibiotic Treatment Trial of GWVI is a randomized placebo-controlled trial to determine whether a 1-year course of doxycycline treatment in deployed Gulf War veterans with GWVI and testing as Mycoplasma species positive will improve their overall functional status as measured by the Physical Component Summary of the SF-36V questionnaire. The study of a multisymptom illness such as GWVI is complicated by the nonspecific nature of the illness, the unknown etiology, and the lack of a widely accepted outcome measure. The presumption of mycoplasma infection raises concerns regarding the methodology for determination of mycoplasma infection, the choice of treatment, and the duration of treatment. However, such a presumption allows the formulation of a clear testable hypothesis that can be tested with treatments with known rates of adverse events and known activity against Mycoplasma species. This paper describes the major issues faced by the investigators during planning, the study design, the patient screening results, and the baseline characteristics of the study patients. There were 2712 patients screened for study entry at 26 Department of Veterans Affairs and two Department of Defense medical centers. Of these, 491 met all study entry criteria and were randomized to either 1 year of doxycycline (200 mg/day) or 1 year of placebo. All patients were seen monthly during treatment and at 6 months after the end of treatment. Study patients had a mean age of 41 years and were mostly male (86%), white (64%), married (68%), and employed full-time (71%). JF - Controlled clinical trials AU - Collins, Joseph F AU - Donta, Sam T AU - Engel, Charles C AU - Baseman, Joel B AU - Dever, Lisa L AU - Taylor, Thomas AU - Boardman, Kathy D AU - Martin, Suzanne E AU - Wiseman, Annette L AU - Feussner, John R AD - Cooperative Studies Program Coordinating Center, VA Medical Center, Perry Point, MD 21902, USA. joseph.collins2@med.va.gov Y1 - 2002/06// PY - 2002 DA - June 2002 SP - 333 EP - 353 VL - 23 IS - 3 SN - 0197-2456, 0197-2456 KW - Anti-Bacterial Agents KW - 0 KW - Doxycycline KW - N12000U13O KW - Index Medicus KW - United States KW - Double-Blind Method KW - Humans KW - Adult KW - Male KW - Female KW - Veterans KW - Anti-Bacterial Agents -- therapeutic use KW - Persian Gulf Syndrome -- physiopathology KW - Persian Gulf Syndrome -- drug therapy KW - Doxycycline -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71806047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Controlled+clinical+trials&rft.atitle=The+antibiotic+treatment+trial+of+Gulf+War+Veterans%27+Illnesses%3A+issues%2C+design%2C+screening%2C+and+baseline+characteristics.&rft.au=Collins%2C+Joseph+F%3BDonta%2C+Sam+T%3BEngel%2C+Charles+C%3BBaseman%2C+Joel+B%3BDever%2C+Lisa+L%3BTaylor%2C+Thomas%3BBoardman%2C+Kathy+D%3BMartin%2C+Suzanne+E%3BWiseman%2C+Annette+L%3BFeussner%2C+John+R&rft.aulast=Collins&rft.aufirst=Joseph&rft.date=2002-06-01&rft.volume=23&rft.issue=3&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Controlled+clinical+trials&rft.issn=01972456&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-12 N1 - Date created - 2002-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of insulin-like growth factor-1 (IGF-1) plus alendronate on bone density during puberty in IGF-1-deficient MIDI mice. AN - 71794405; 12052462 AB - Insulin-like growth factor-1 (IGF-1) increases both bone formation and bone resorption processes. To test the hypothesis that treatment with an antiresorber along with IGF-1, during the pubertal growth phase, would be more effective than IGF-1 alone to increase peak bone mass, we used an IGF-1 MIDI mouse model, which exhibits a >60% reduction in circulating IGF-1 levels. We first determined an optimal IGF-1 delivery by evaluating IGF-1 administration (2 mg/kg body weight/day) by either a single daily injection, three daily injections, or by continuous delivery via a minipump during puberty. Of the three regimens, the three daily IGF-1 injections and IGF-1 through a minipump produced a significant increase in total body bone mineral density (BMD) (6.0% and 4.4%, respectively) and in femoral BMD (4.3% and 6.2%, respectively) compared with the control group. Single subcutaneous (s.c.) administration did not increase BMD. We chose IGF-1 administration three times daily for testing the combined effects of IGF-1 and alendronate (100 microg/kg per day). The treatment of IGF-1 + alendronate for a period of 2 weeks increased total body BMD at 1 week and 3 weeks after treatment (21.1% and 20.5%, respectively) and femoral BMD by 29% at 3 weeks after treatment. These increases were significantly greater than those produced by IGF-1 alone. IGF-1, but not alendronate, increased bone length. IGF-1 and/or alendronate increased both periosteal and endosteal circumference. Combined treatment caused a greater increase in the total body bone mineral content (BMC) and periosteal circumference compared with individual treatment with IGF-1 or alendronate. Our data demonstrate that: (1) inhibition of bone turnover during puberty increases net bone density; and (2) combined treatment with IGF-1 and alendronate is more effective than IGF-1 or alendronate alone in increasing peak bone mass in an IGF-1-deficient MIDI mouse model. JF - Bone AU - Stabnov, L AU - Kasukawa, Y AU - Guo, R AU - Amaar, Y AU - Wergedal, J E AU - Baylink, D J AU - Mohan, S AD - Musculoskeletal Disease Center, Jerry L. Pettis Veterans Administration Medical Center, Loma Linda, CA 92357, USA. Y1 - 2002/06// PY - 2002 DA - June 2002 SP - 909 EP - 916 VL - 30 IS - 6 SN - 8756-3282, 8756-3282 KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Alendronate KW - X1J18R4W8P KW - Index Medicus KW - Animals KW - Mice KW - Drug Synergism KW - Male KW - Female KW - Mice, Knockout KW - Sexual Maturation -- drug effects KW - Insulin-Like Growth Factor I -- genetics KW - Bone Density -- drug effects KW - Sexual Maturation -- physiology KW - Insulin-Like Growth Factor I -- deficiency KW - Bone Density -- physiology KW - Alendronate -- pharmacology KW - Insulin-Like Growth Factor I -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71794405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bone&rft.atitle=Effect+of+insulin-like+growth+factor-1+%28IGF-1%29+plus+alendronate+on+bone+density+during+puberty+in+IGF-1-deficient+MIDI+mice.&rft.au=Stabnov%2C+L%3BKasukawa%2C+Y%3BGuo%2C+R%3BAmaar%2C+Y%3BWergedal%2C+J+E%3BBaylink%2C+D+J%3BMohan%2C+S&rft.aulast=Stabnov&rft.aufirst=L&rft.date=2002-06-01&rft.volume=30&rft.issue=6&rft.spage=909&rft.isbn=&rft.btitle=&rft.title=Bone&rft.issn=87563282&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-12-10 N1 - Date created - 2002-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Atypical antipsychotics: enhancing healthy outcomes. AN - 71785173; 12046020 JF - Archives of psychiatric nursing AU - Casey, Daniel E AD - Mental Illness Research, Education and Clinical Center, MIRECC VISN 20, Portland VA Medical Center and the Department of Psychiatry, Oregon Health Sciences University, Portland, OR 97201, USA. Daniel.casey@med.va.gov Y1 - 2002/06// PY - 2002 DA - June 2002 SP - S12 EP - S19 VL - 16 IS - 3 Suppl 1 SN - 0883-9417, 0883-9417 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Nursing KW - Risk Factors KW - Humans KW - Diabetes Mellitus -- chemically induced KW - Diabetes Mellitus -- epidemiology KW - Obesity -- epidemiology KW - Obesity -- chemically induced KW - Smoking -- epidemiology KW - Schizophrenia -- mortality KW - Cardiovascular Diseases -- epidemiology KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects KW - Schizophrenia -- complications KW - Cardiovascular Diseases -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71785173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+psychiatric+nursing&rft.atitle=Atypical+antipsychotics%3A+enhancing+healthy+outcomes.&rft.au=Casey%2C+Daniel+E&rft.aulast=Casey&rft.aufirst=Daniel&rft.date=2002-06-01&rft.volume=16&rft.issue=3+Suppl+1&rft.spage=S12&rft.isbn=&rft.btitle=&rft.title=Archives+of+psychiatric+nursing&rft.issn=08839417&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-08-28 N1 - Date created - 2002-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thrombosis: new culprits in an old disorder. AN - 71744765; 12032428 AB - Venous thrombosis is a cause of considerable morbidity and mortality. Over the past several years, several new causes of thrombophilia have been identified and have dramatically altered the approach to patients presenting with thrombosis. Newly described abnormalities associated with thrombophilia include the syndrome of activated Protein C resistance (APCR), the prothrombin 20210A mutation, hyperhomocysteinemia, and elevated levels of coagulation factors VIII and XI. Clinicians can now frequently determine causes of thromboses that have previously been deemed idiopathic. Though the risk factors for VTE are becoming better defined, the cost-effective approach to diagnosis and therapeutic implications are not entirely clear at this point. JF - Panminerva medica AU - Federman, D G AU - Moriarty, J P AU - Kravetz, J D AU - Kirsner, R S AD - VA Connecticut Health Care System and Department of Medicine, Yale University School of Medicine, New Haven, CT, USA. Daniel.Federman@med.va.gov Y1 - 2002/06// PY - 2002 DA - June 2002 SP - 107 EP - 113 VL - 44 IS - 2 SN - 0031-0808, 0031-0808 KW - Anticoagulants KW - 0 KW - Contraceptives, Oral KW - factor V Leiden KW - Factor V KW - 9001-24-5 KW - Prothrombin KW - 9001-26-7 KW - Factor VIII KW - 9001-27-8 KW - Factor XI KW - 9013-55-2 KW - Index Medicus KW - Contraceptives, Oral -- adverse effects KW - Factor VIII -- metabolism KW - Thromboembolism -- etiology KW - Thrombophilia -- etiology KW - Anticoagulants -- therapeutic use KW - Humans KW - Factor XI -- metabolism KW - Prothrombin -- genetics KW - Pregnancy KW - Hyperhomocysteinemia -- complications KW - Risk Factors KW - Activated Protein C Resistance -- genetics KW - Activated Protein C Resistance -- complications KW - Factor V -- genetics KW - Mutation KW - Female KW - Venous Thrombosis -- etiology KW - Venous Thrombosis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71744765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Panminerva+medica&rft.atitle=Thrombosis%3A+new+culprits+in+an+old+disorder.&rft.au=Federman%2C+D+G%3BMoriarty%2C+J+P%3BKravetz%2C+J+D%3BKirsner%2C+R+S&rft.aulast=Federman&rft.aufirst=D&rft.date=2002-06-01&rft.volume=44&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Panminerva+medica&rft.issn=00310808&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-08-19 N1 - Date created - 2002-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. AN - 71716395; 12029625 AB - Conversion of cholesterol into 7alpha-hydroxylated bile acids is a principal pathway of cholesterol disposal. Cholesterol 7alpha-hydroxylase (CYP7A1) is the initial and rate-determining enzyme in the "classic" pathway of bile acid synthesis. An "alternative" pathway of bile acid synthesis is initiated by sterol 27-hydroxylase (CYP27) with subsequent 7alpha-hydroxylation of 27-hydroxycholesterol by oxysterol 7alpha-hydroxylase (CYP7B1). The regulation of CYP7B1, possibly a rate-determining enzyme in the alternative pathway, has not been thoroughly studied. The aims of this study were to (1) study the regulation of liver CYP7B1 by bile acids, cholesterol, adenosine 3', 5'-cyclic monophosphate (cAMP), and phorbol myristate acetate (PMA) in primary rat hepatocytes and (2) determine the effect of CYP7B1 overexpression on rates of bile acid synthesis. The effects of different bile acids (3-150 micromol/L), cAMP (50 micromol/L), PMA (100 nmol/L; protein kinase C stimulator), cholesterol (200 micromol/L), and squalestatin (1 micromol/L; cholesterol synthesis inhibitor) on CYP7B1 expression in primary rat hepatocytes were studied. Taurocholic acid and taurodeoxycholic acid decreased CYP7B1 activity by 45% +/- 10% and 36% +/- 7%, respectively. Tauroursodeoxycholic acid and taurochenodeoxycholic acid did not alter CYP7B1 activity. Inhibition of cholesterol synthesis with squalestatin decreased CYP7B1 activity by 35%, whereas addition of cholesterol increased activity by 39%. Both PMA and cAMP decreased CYP7B1 activity by 60% and 34%, respectively, in a time-dependent fashion. Changes in CYP7B1 messenger RNA (mRNA) levels correlated with changes in specific activities. Overexpression of CYP7B1 led to a marked increase in CYP7B1 mRNA levels and specific activity but no change in rates of bile acid synthesis. In conclusion, in the rat, CYP7B1 specific activity is highly regulated but does not seem to be rate limiting for bile acid synthesis. JF - Hepatology (Baltimore, Md.) AU - Pandak, William M AU - Hylemon, Phillip B AU - Ren, Shunlin AU - Marques, Dalila AU - Gil, Gregorio AU - Redford, Kaye AU - Mallonee, Darrell AU - Vlahcevic, Z Rano AD - Department of Medicine, Veterans Affairs Medical Center and Virginia Commonwealth University, Richmond, VA 23249, USA. william.pandak@med.va.gov Y1 - 2002/06// PY - 2002 DA - June 2002 SP - 1400 EP - 1408 VL - 35 IS - 6 SN - 0270-9139, 0270-9139 KW - Carcinogens KW - 0 KW - Cholagogues and Choleretics KW - Glucocorticoids KW - RNA, Messenger KW - Taurodeoxycholic Acid KW - 516-50-7 KW - Taurocholic Acid KW - 5E090O0G3Z KW - Bucladesine KW - 63X7MBT2LQ KW - Dexamethasone KW - 7S5I7G3JQL KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Cholesterol KW - 97C5T2UQ7J KW - Steroid Hydroxylases KW - EC 1.14.- KW - oxysterol 7-alpha-hydroxylase KW - EC 1.14.13.- KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Thyroxine KW - Q51BO43MG4 KW - Index Medicus KW - Animals KW - Carcinogens -- pharmacology KW - Cholagogues and Choleretics -- pharmacology KW - Dexamethasone -- pharmacology KW - Cholesterol -- pharmacology KW - RNA, Messenger -- analysis KW - Enzyme Activation -- physiology KW - Taurodeoxycholic Acid -- pharmacology KW - Bucladesine -- pharmacology KW - Glucocorticoids -- pharmacology KW - Rats KW - Thyroxine -- pharmacology KW - Rats, Sprague-Dawley KW - Cells, Cultured KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Gene Expression Regulation, Enzymologic -- physiology KW - Enzyme Activation -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Male KW - Taurocholic Acid -- pharmacology KW - Cytochrome P-450 Enzyme System -- genetics KW - Steroid Hydroxylases -- genetics KW - Hepatocytes -- cytology KW - Hepatocytes -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71716395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Regulation+of+oxysterol+7alpha-hydroxylase+%28CYP7B1%29+in+primary+cultures+of+rat+hepatocytes.&rft.au=Pandak%2C+William+M%3BHylemon%2C+Phillip+B%3BRen%2C+Shunlin%3BMarques%2C+Dalila%3BGil%2C+Gregorio%3BRedford%2C+Kaye%3BMallonee%2C+Darrell%3BVlahcevic%2C+Z+Rano&rft.aulast=Pandak&rft.aufirst=William&rft.date=2002-06-01&rft.volume=35&rft.issue=6&rft.spage=1400&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-21 N1 - Date created - 2002-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Maintenance of elevated fetal hemoglobin levels by decitabine during dose interval treatment of sickle cell anemia. AN - 71701611; 12010787 AB - We have previously demonstrated that 5-aza-2'-deoxycytidine (decitabine) augments fetal hemoglobin (HbF) levels in patients with sickle cell anemia (SS) who did not respond to hydroxyurea (HU). The present study was designed to determine the effect of repeated decitabine dosing on HbF levels and hematologic toxicity over a 9-month treatment period. Seven patients (5 HU nonresponders) were entered. One patient had alpha-thalassemia sickle cell anemia. Decitabine was administered by intravenous infusion at a starting dose of 0.3 mg/kg per day, 5 days a week for 2 weeks, followed by a 4-week observation period. If the absolute neutrophil count dropped below 1000, the dose was reduced by 0.05 mg/kg per day in the next cycle. A drug dose was obtained for each patient, and it resulted in an elevated HbF without neutropenia (absolute neutrophil count nadir greater than 1500) or evidence of cumulative toxicity. Average HbF and average maximal HbF levels attained during the last 20 weeks of treatment for the 6 SS patients increased to 13.93% +/- 2.75% and 18.35% +/- 4.46%, respectively, from a pretreatment mean of 3.12% +/- 2.75%. Mean and mean maximal hemoglobin (Hb) levels increased from 7.23 +/- 2.35 g/dL to 8.81 +/- 0.42 g/dL and 9.73 +/- 0.53 g/dL, respectively. Individual maximal F-cell number observed during the trial was 69% +/- 10.12%. The absence of cumulative toxicity may allow shorter intervals between drug treatments, which may lead to higher hemoglobin and HbF levels after several treatment cycles and, therefore, to greater clinical improvement. JF - Blood AU - DeSimone, Joseph AU - Koshy, Mabel AU - Dorn, Louise AU - Lavelle, Donald AU - Bressler, Linda AU - Molokie, Robert AU - Talischy, Nasrin AD - University of Illinois at Chicago and the Veterans Administration Chicago West Side Division, IL 60612, USA. jdesimon@uic.edu Y1 - 2002/06/01/ PY - 2002 DA - 2002 Jun 01 SP - 3905 EP - 3908 VL - 99 IS - 11 SN - 0006-4971, 0006-4971 KW - decitabine KW - 776B62CQ27 KW - Fetal Hemoglobin KW - 9034-63-3 KW - DNA Modification Methylases KW - EC 2.1.1.- KW - Azacitidine KW - M801H13NRU KW - Abridged Index Medicus KW - Index Medicus KW - Neutrophils KW - Humans KW - DNA Modification Methylases -- antagonists & inhibitors KW - Injections, Subcutaneous KW - Reticulocyte Count KW - Time Factors KW - Leukocyte Count KW - Azacitidine -- therapeutic use KW - Azacitidine -- analogs & derivatives KW - Fetal Hemoglobin -- metabolism KW - Anemia, Sickle Cell -- blood KW - Fetal Hemoglobin -- drug effects KW - Anemia, Sickle Cell -- drug therapy KW - Azacitidine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71701611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Maintenance+of+elevated+fetal+hemoglobin+levels+by+decitabine+during+dose+interval+treatment+of+sickle+cell+anemia.&rft.au=DeSimone%2C+Joseph%3BKoshy%2C+Mabel%3BDorn%2C+Louise%3BLavelle%2C+Donald%3BBressler%2C+Linda%3BMolokie%2C+Robert%3BTalischy%2C+Nasrin&rft.aulast=DeSimone&rft.aufirst=Joseph&rft.date=2002-06-01&rft.volume=99&rft.issue=11&rft.spage=3905&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-01 N1 - Date created - 2002-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of a Sensitive and Specific Enzyme-Linked Immunosorbent Assay for Detecting and Quantifying CMY-2 and SHV beta -Lactamases AN - 18469521; 5430939 AB - Polyclonal rabbit antibodies against SHV-1 and CMY-2 beta -lactamases were produced and characterized, and enzyme-linked immunosorbent assays (ELISAs) were developed. Immunoblots revealed that the anti-SHV-1 antibody recognized SHV-1 but did not recognize TEM-1, K-1, OXA-1, or any AmpC beta -lactamase tested. The anti-CMY-2 antibody detected Escherichia coli CMY-2, Enterobacter cloacae P99, Klebsiella pneumoniae ACT-1, and the AmpC beta -lactamases of Enterobacter aerogenes, Morganella morganii, and Citrobacter freundii. No cross-reactivity of the anti-CMY-2 antibody was seen against laboratory strains of E. coli possessing TEM-1, SHV-1, K-1, or OXA-1 beta - lactamases. Operating conditions for performing ELISAs were optimized. Both anti-CMY-2 and anti-SHV-1 antibodies detected picogram quantities of purified protein in ELISAs. The reactivity of the anti-CMY-2 antibody was tested against a number of AmpC beta -lactamases by assaying known quantities of purified enzymes in ELISAs (AmpC beta -lactamases of M. morganii, C. freundii, E. coli, and E. cloacae). As the homology to CMY-2 beta -lactamase decreased, the minimum level needed for detection increased (e.g., 94% homology recognized at 1 ng/ml and 71% homology recognized at 10 ng/ml). The ELISAs were used to assay unknown clinical isolates for AmpC and SHV beta -lactamases, and the results were confirmed with PCR amplification of bla sub(AmpC) and bla sub(SHV) genes. Overall, we found that our ELISAs were at least 95% sensitive and specific for detecting SHV and AmpC beta -lactamases. The ELISA format can facilitate the identification of AmpC and SHV beta -lactamases and can be used to quantify relative amounts of beta -lactamase enzymes in clinical and laboratory isolates. JF - Journal of Clinical Microbiology AU - Hujer, AM AU - Page, MGP AU - Helfand AU - Yeiser, B AU - Bonomo, R A AD - Infectious Disease, Louis Stokes Veterans Affairs Medical Center, 10701 East Blvd., Cleveland, OH 44106., robert.bonomo@med.va.gov Y1 - 2002/06// PY - 2002 DA - Jun 2002 SP - 1947 EP - 1957 VL - 40 IS - 6 SN - 0095-1137, 0095-1137 KW - rabbits KW - Microbiology Abstracts B: Bacteriology KW - J 02831:Techniques and reagents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18469521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Development+of+a+Sensitive+and+Specific+Enzyme-Linked+Immunosorbent+Assay+for+Detecting+and+Quantifying+CMY-2+and+SHV+beta+-Lactamases&rft.au=Hujer%2C+AM%3BPage%2C+MGP%3BHelfand%3BYeiser%2C+B%3BBonomo%2C+R+A&rft.aulast=Hujer&rft.aufirst=AM&rft.date=2002-06-01&rft.volume=40&rft.issue=6&rft.spage=1947&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.40.6.1947-1957.2002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1128/JCM.40.6.1947-1957.2002 ER - TY - JOUR T1 - Linezolid versus Vancomycin for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections AN - 18458083; 5433486 AB - Linezolid, the first available member of a new antibiotic class, the oxazolidinones, is broadly active against gram-positive bacteria, including drug-resistant strains. In this randomized, open-label trial, hospitalized adults with known or suspected methicillin-resistant Staphylococcus aureus (MRSA) infections were treated with linezolid (600 mg twice daily; n = 240) or vancomycin (1 g twice daily; n = 220) for 7-28 days. S. aureus was isolated from 53% of patients; 93% of these isolates were MRSA. Skin and soft-tissue infection was the most common diagnosis, followed by pneumonia and urinary tract infection. At the test-of-cure visit (15-21 days after the end of therapy), among evaluable patients with MRSA, there was no statistical difference between the 2 treatment groups with respect to clinical cure rates (73.2% of patients in the linezolid group and 73.1% in the vancomycin group) or microbiological success rates (58.9% in the linezolid group and 63.2% in the vancomycin group). Both regimens were well tolerated, with similar rates of adverse events. JF - Clinical Infectious Diseases AU - Stevens, D L AU - Herr, D AU - Lampiris, H AU - Hunt, J L AU - Batts, D H AU - Hafkin, B AD - Infectious Diseases Section, Veterans Administration Medical Center, Boise, Idaho, USA Y1 - 2002/06/01/ PY - 2002 DA - 2002 Jun 01 SP - 1481 EP - 1490 VL - 34 IS - 11 SN - 1058-4838, 1058-4838 KW - linezolid KW - man KW - oxazolidinones KW - vancomycin KW - Microbiology Abstracts B: Bacteriology KW - J 02843:Skin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18458083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Linezolid+versus+Vancomycin+for+the+Treatment+of+Methicillin-Resistant+Staphylococcus+aureus+Infections&rft.au=Stevens%2C+D+L%3BHerr%2C+D%3BLampiris%2C+H%3BHunt%2C+J+L%3BBatts%2C+D+H%3BHafkin%2C+B&rft.aulast=Stevens&rft.aufirst=D&rft.date=2002-06-01&rft.volume=34&rft.issue=11&rft.spage=1481&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Combinations of Lysostaphin with beta -Lactams Are Synergistic against Oxacillin-Resistant Staphylococcus epidermidis AN - 18452427; 5424445 AB - Oxacillin-resistant Staphylococcus aureus is rapidly killed by the endopeptidase lysostaphin, and the addition of beta -lactam antibiotics provides synergistic killing. We investigated the possibility that beta -lactams given in combination with lysostaphin would improve the activity of lysostaphin against oxacillin-resistant Staphylococcus epidermidis (ORSE), which is normally less susceptible to lysostaphin. Checkerboard synergy testing was performed for lysostaphin given in combination with oxacillin against 10 ORSE isolates for which the lysostaphin MICs were >= 8 mu g/ml. The fractional inhibitory concentration index ranged from 0.0234 to 0.2656, indicating synergy, which was confirmed in growth curve experiments. In the rabbit model of experimental aortic valve endocarditis using an ORSE strain, the combination of lysostaphin and nafcillin was as effective as vancomycin alone and significantly better than lysostaphin or nafcillin alone. We conclude that beta -lactam antibiotics given in combination with lysostaphin are synergistic against many strains of ORSE. JF - Antimicrobial Agents & Chemotherapy AU - Kiri, N AU - Archer, G AU - Climo, M W AD - Hunter Holmes McGuire Veteran Affairs Medical Center, 1201 Broad Rock Blvd., Section 111-C, Richmond, VA 23249, michael.climo@med.va.gov Y1 - 2002/06// PY - 2002 DA - Jun 2002 SP - 2017 EP - 2020 VL - 46 IS - 6 SN - 0066-4804, 0066-4804 KW - endopeptidase KW - lysostaphin KW - rabbits KW - Microbiology Abstracts B: Bacteriology KW - J 02787:Peptide and protein antibiotics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18452427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Combinations+of+Lysostaphin+with+beta+-Lactams+Are+Synergistic+against+Oxacillin-Resistant+Staphylococcus+epidermidis&rft.au=Kiri%2C+N%3BArcher%2C+G%3BClimo%2C+M+W&rft.aulast=Kiri&rft.aufirst=N&rft.date=2002-06-01&rft.volume=46&rft.issue=6&rft.spage=2017&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.46.6.2017-2020.2002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1128/AAC.46.6.2017-2020.2002 ER - TY - JOUR T1 - Educating physicians prepared to improve care and safety is no accident: it requires a systematic approach AN - 17049785; 5557215 AB - While most newly qualified physicians are well prepared in the science base of medicine and in the skills that enable them to look after individual patients, few have the skills necessary to improve care and patient safety continuously. We apply a systems analysis from the field of human error to identify ways in which medical school education can increase the number of graduates prepared to reflect on and improve professional practice. Doing so requires a systematic approach involving entrance requirements, the curriculum, the organizational culture of training environments, student assessment, and program evaluation. JF - Quality & Safety in Health Care AU - Aron, D C AU - Headrick, LA AD - Education Office 14(W), Louis Stokes Cleveland DVA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA, david.aron@med.va.gov Y1 - 2002/06// PY - 2002 DA - Jun 2002 SP - 168 EP - 173 VL - 11 IS - 2 SN - 1475-3898, 1475-3898 KW - Health & Safety Science Abstracts KW - H 13000:Medical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17049785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quality+%26+Safety+in+Health+Care&rft.atitle=Educating+physicians+prepared+to+improve+care+and+safety+is+no+accident%3A+it+requires+a+systematic+approach&rft.au=Aron%2C+D+C%3BHeadrick%2C+LA&rft.aulast=Aron&rft.aufirst=D&rft.date=2002-06-01&rft.volume=11&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Quality+%26+Safety+in+Health+Care&rft.issn=14753898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Dimerization of v-erbA on inverted repeats. AN - 71805540; 12054736 AB - Thyroid hormone receptors (TRs) and the oncoprotein v-erbA can heterodimerize with retinoid X receptor (RXR) on core motifs arranged as inverted repeats (IR0) which contain the consensus sequence AGGTCA. On this core motif, v-erbA can also form homodimers whereas TRs homodimerize very poorly. Therefore to obtain a better understanding of distinct homodimerization properties of TR alpha 1 as compared to those of v-erbA, we created chimeras between these two receptors and tested their abilities to homodimerize on IR0. We found that the enhanced homodimerization properties of v-erbA compared to those of TR alpha 1 on IR0 map to amino acids 107-156 in v-erbA/121-170 in TR alpha 1 (VT-2 chimera). Furthermore, functional studies on transient transfections showed that v-erbA-RXR heterodimers do not mediate the dominant negative activity of v-erbA on an inverted repeat response element. These data, in conjunction with our previous studies, indicate that v-erbA homodimers mediate the repressor activity of v-erbA on IR0. JF - Biochemical and biophysical research communications AU - Zubkova, Inna AU - Subauste, Jose S AD - Division of Endocrinology and Metabolism, Department of Medicine, G.V. Montgomery Veterans Administration Medical Center, University of Mississippi, Jackson, MS 39216, USA. Y1 - 2002/05/31/ PY - 2002 DA - 2002 May 31 SP - 35 EP - 41 VL - 294 IS - 1 SN - 0006-291X, 0006-291X KW - Oncogene Proteins v-erbA KW - 0 KW - Receptors, Retinoic Acid KW - Receptors, Thyroid Hormone KW - Recombinant Fusion Proteins KW - Retinoid X Receptors KW - Thyroid Hormone Receptors alpha KW - Transcription Factors KW - Index Medicus KW - Receptors, Retinoic Acid -- metabolism KW - Animals KW - Transcription Factors -- metabolism KW - Electrophoresis, Polyacrylamide Gel KW - Receptors, Thyroid Hormone -- genetics KW - Receptors, Thyroid Hormone -- metabolism KW - Mice KW - Protein Binding KW - Structure-Activity Relationship KW - Mutagenesis, Site-Directed KW - Recombinant Fusion Proteins -- metabolism KW - Point Mutation KW - Cell Line KW - Oncogene Proteins v-erbA -- chemistry KW - Dimerization KW - Oncogene Proteins v-erbA -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71805540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Dimerization+of+v-erbA+on+inverted+repeats.&rft.au=Zubkova%2C+Inna%3BSubauste%2C+Jose+S&rft.aulast=Zubkova&rft.aufirst=Inna&rft.date=2002-05-31&rft.volume=294&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-22 N1 - Date created - 2002-06-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The impact of anemia on quality of life in human immunodeficiency virus-infected patients. AN - 71663354; 12001031 AB - Anemia is the most commonly encountered hematologic abnormality in human immunodeficiency virus (HIV)-positive patients, occurring with increasing frequency as the disease progresses. Several factors play a role in the development of anemia in patients with HIV, including chronic disease, opportunistic infections, and certain nutritional deficiencies. Despite the high prevalence of anemia in this population, the symptoms of anemia are frequently overlooked, although anemia can significantly affect a patient's ability to carry on even normal activities of daily living. Therefore, approaches--including the treatment of causative infections, discontinuation of certain drugs, or use of recombinant human erythropoietin (epoetin alfa)--aimed at increasing hemoglobin levels to normal or near-normal levels would be expected to improve quality of life (QOL). The purpose of this article is to describe the effects of anemia on QOL and to provide an overview of several studies showing that QOL improves with the alleviation of anemia. JF - The Journal of infectious diseases AU - Volberding, Paul AD - Medical Service, University of California, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, CA. paul.volberding@med.va.gov Y1 - 2002/05/15/ PY - 2002 DA - 2002 May 15 SP - S110 EP - S114 VL - 185 Suppl 2 SN - 0022-1899, 0022-1899 KW - Hematinics KW - 0 KW - Hemoglobins KW - Recombinant Proteins KW - Erythropoietin KW - 11096-26-7 KW - Epoetin Alfa KW - 64FS3BFH5W KW - Abridged Index Medicus KW - Index Medicus KW - Antiretroviral Therapy, Highly Active -- adverse effects KW - Hemoglobins -- analysis KW - Humans KW - Hematinics -- therapeutic use KW - Erythropoietin -- therapeutic use KW - Clinical Trials as Topic KW - HIV Infections -- physiopathology KW - HIV Infections -- complications KW - HIV Infections -- blood KW - Anemia -- physiopathology KW - Anemia -- drug therapy KW - Quality of Life KW - Anemia -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71663354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=The+impact+of+anemia+on+quality+of+life+in+human+immunodeficiency+virus-infected+patients.&rft.au=Volberding%2C+Paul&rft.aulast=Volberding&rft.aufirst=Paul&rft.date=2002-05-15&rft.volume=185+Suppl+2&rft.issue=&rft.spage=S110&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-14 N1 - Date created - 2002-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Asbestos-induced alveolar epithelial cell apoptosis: role of mitochondrial dysfunction caused by iron-derived free radicals. AN - 71987771; 12162428 AB - Asbestos causes asbestosis and malignancies by mechanisms that are not fully understood. Alveolar epithelial cell (AEC) injury by iron-derived reactive oxygen species (ROS) is one important mechanism implicated. We previously showed that iron-catalyzed ROS in part mediate asbestos-inducedAEC DNA damage and apoptosis. Mitochondria have a critical role in regulating apoptosis after exposure to agents causing DNA damage but their role in regulating asbestos-induced apoptosis is unknown. To determine whether asbestos causes AEC mitochondrial dysfunction, we exposed A549 cells to amosite asbestos and assessed mitochondrial membrane potential changes (delta(psi)m) using a fluorometric technique involving tetremethylrhodamine ethyl ester (TMRE) and mitotracker green. We show that amosite asbestos, but not an inert particulate, titanium dioxide, reduces delta(psi)m after a 4 h exposure period. Further, the delta(psi)m after 4 h was inversely proportional to the levels of apoptosis noted at 24 h as assessed by nuclear morphology as well as by DNA nucleosome formation. A role for iron-derived ROS was suggested by the finding that phytic acid, an iron chelator, blocked asbestos-induced reductions in A549 cell delta(psi)m and attenuated apoptosis. Finally, overexpression of Bcl-xl, an anti-apoptotic protein that localizes to the mitochondria, prevented asbestos-induced decreases in A549 cell delta(psi)m after 4 h and diminished apoptosis. We conclude that asbestos alters AEC mitochondrial function in part by generating iron-derived ROS, which in turn can result in apoptosis. This suggests that the mitochondrial death pathway is important in regulating pulmonary toxicity from asbestos. JF - Molecular and cellular biochemistry AU - Kamp, David W AU - Panduri, Vij ayalakshmi AU - Weitzman, Sigmund A AU - Chandel, Navdeep AD - Veterans Administration Chicago Health Care System: Lakeside Division, Northwestern University Medical School, IL, USA. PY - 2002 SP - 153 EP - 160 VL - 234-235 IS - 1-2 SN - 0300-8177, 0300-8177 KW - BCL2L1 protein, human KW - 0 KW - Free Radicals KW - Proto-Oncogene Proteins c-bcl-2 KW - bcl-X Protein KW - Asbestos KW - 1332-21-4 KW - Phytic Acid KW - 7IGF0S7R8I KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Intracellular Membranes -- drug effects KW - Humans KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Phytic Acid -- pharmacology KW - Membrane Potentials -- drug effects KW - Cell Line KW - Pulmonary Alveoli -- pathology KW - Mitochondria -- pathology KW - Asbestos -- pharmacology KW - Respiratory Mucosa -- drug effects KW - Asbestos -- toxicity KW - Free Radicals -- metabolism KW - Respiratory Mucosa -- pathology KW - Iron -- metabolism KW - Respiratory Mucosa -- metabolism KW - Apoptosis -- drug effects KW - Mitochondria -- drug effects KW - Mitochondria -- metabolism KW - Asbestos -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71987771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biochemistry&rft.atitle=Asbestos-induced+alveolar+epithelial+cell+apoptosis%3A+role+of+mitochondrial+dysfunction+caused+by+iron-derived+free+radicals.&rft.au=Kamp%2C+David+W%3BPanduri%2C+Vij+ayalakshmi%3BWeitzman%2C+Sigmund+A%3BChandel%2C+Navdeep&rft.aulast=Kamp&rft.aufirst=David&rft.date=2002-05-01&rft.volume=234-235&rft.issue=1-2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biochemistry&rft.issn=03008177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-02-14 N1 - Date created - 2002-08-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Treatment of refractory acute leukemia with timed sequential chemotherapy using topotecan followed by etoposide + mitoxantrone (T-EM) and correlation with topoisomerase II levels. AN - 71985589; 12148910 AB - A phase I/II clinical study evaluated 17 patients with refractory/recurrent acute leukemia treated with 1.5 mg/m2/day topotecan on days 1-3 followed by etoposide (100 mg/m2/day)+mitoxantrone (10 mg/m2/day) on days 4, 5 and 9, 10. Timed sequential chemotherapy using the topoisomerase I-inhibitor topotecan before the topoisomerase II-inhibitors, etoposide+mitoxantrone (T-EM) treatment is proposed to induce topoisomerase II protein levels and potentiate the cytotoxic activity of the topoisomerase II-directed drugs. Fourteen patients had refractory and three had recurrent acute leukemia. The majority of patients were heavily pre-treated with greater than three re-induction chemotherapy regimens. Ten patients responded to T-EM treatment (59%). Four of seventeen (24%) had a complete remission and one had a partial remission. Four additional patients (24%) who scored complete leukemia clearance had no evidence of disease with complete white and red blood cell recovery but with platelet counts less than 100,000. The lack of platelet recovery in one patient having a partial response was scored as a partial leukemia clearance. The toxicity profile included major non-hematological toxicity including grade 3 mucositis (29%) and neutropenic fever (65%). Paired measurements of intracellular levels of topoisomerase II isoforms alpha and beta in leukemia blast cells (bone marrow) collected before (day 0) and after topotecan treatment (day 4) showed that a relative increase of topoisomerase IIalpha (Topo IIalpha) > or = 40% strongly correlated with response after T-EM treatment. Increased Topo IIalpha levels also corresponded to increased DNA fragmentation. Two patients who had an increase of Topo IIalpha of 20-25% had either a PR or PLC while patients with a < 10% increase showed no response to T-EM treatment. We conclude that timed sequential chemotherapy using topotecan followed by etoposide+mitoxantrone is an effective regimen for patients with refractory acute leukemia, and demonstrate Topo IIalpha protein level increases after topotecan treatment. JF - Leukemia & lymphoma AU - Mainwaring, M G AU - Rimsza, L M AU - Chen, S F AU - Gomez, S P AU - Weeks, F W AU - Reddy, V AU - Lynch, J AU - May, W S AU - Kahn, S AU - Moreb, J AU - Leather, H AU - Braylan, R AU - Rowe, T C AU - Fieniewicz, K J AU - Wingard, J R AD - University of Florida College of Medicine, Division of Hematology/Oncology, Gainesville, USA. mark.mainwaring@med.va.gov Y1 - 2002/05// PY - 2002 DA - May 2002 SP - 989 EP - 999 VL - 43 IS - 5 SN - 1042-8194, 1042-8194 KW - Etoposide KW - 6PLQ3CP4P3 KW - Topotecan KW - 7M7YKX2N15 KW - Mitoxantrone KW - BZ114NVM5P KW - DNA Topoisomerases, Type II KW - EC 5.99.1.3 KW - Index Medicus KW - Acute Disease KW - Humans KW - Mitoxantrone -- administration & dosage KW - Aged KW - Etoposide -- administration & dosage KW - Adult KW - Topotecan -- administration & dosage KW - Enzyme Induction KW - Middle Aged KW - Adolescent KW - DNA Fragmentation KW - Female KW - Male KW - DNA Topoisomerases, Type II -- biosynthesis KW - Leukemia -- drug therapy KW - DNA Topoisomerases, Type II -- analysis KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Leukemia -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71985589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+%26+lymphoma&rft.atitle=Treatment+of+refractory+acute+leukemia+with+timed+sequential+chemotherapy+using+topotecan+followed+by+etoposide+%2B+mitoxantrone+%28T-EM%29+and+correlation+with+topoisomerase+II+levels.&rft.au=Mainwaring%2C+M+G%3BRimsza%2C+L+M%3BChen%2C+S+F%3BGomez%2C+S+P%3BWeeks%2C+F+W%3BReddy%2C+V%3BLynch%2C+J%3BMay%2C+W+S%3BKahn%2C+S%3BMoreb%2C+J%3BLeather%2C+H%3BBraylan%2C+R%3BRowe%2C+T+C%3BFieniewicz%2C+K+J%3BWingard%2C+J+R&rft.aulast=Mainwaring&rft.aufirst=M&rft.date=2002-05-01&rft.volume=43&rft.issue=5&rft.spage=989&rft.isbn=&rft.btitle=&rft.title=Leukemia+%26+lymphoma&rft.issn=10428194&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-11-07 N1 - Date created - 2002-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anti-leukemia effect of resveratrol. AN - 71979526; 12148909 AB - Resveratrol is a phytoalexin naturally present in fruits, medicinal plants and wines. It has a diversity of biological activities. While its role in the protection against coronary heart disease (CHD) in people with moderate wine consumption, remains unclear, resveratrol preferentially inhibits the growth of leukemia cells in culture. Potential mechanisms for its anti-leukemia effect include induction of leukemia cell differentiation, apoptosis, and cell cycle arrest at S-phase; and inhibition of DNA synthesis by inhibiting ribonucleotide reductase or DNA polymerase. Preliminary results suggest that resveratrol also inhibits the viability of freshly isolated leukemia cells, especially promyelocytic leukemia cells. Because of its low in vivo toxicity, resveratrol deserves further investigation as an anti-leukemia agent. JF - Leukemia & lymphoma AU - Tsan, Min-Fu AU - White, Julie E AU - Maheshwari, Jewraj G AU - Chikkappa, G AD - Office of Research Compliance and Assurance, Department of Veterans Affairs, Washington, DC 20422, USA. min-fu.tsan2@med.va.gov Y1 - 2002/05// PY - 2002 DA - May 2002 SP - 983 EP - 987 VL - 43 IS - 5 SN - 1042-8194, 1042-8194 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Stilbenes KW - resveratrol KW - Q369O8926L KW - Index Medicus KW - Humans KW - Apoptosis -- drug effects KW - Cell Cycle -- drug effects KW - Hematopoietic Stem Cells -- drug effects KW - Leukemia -- drug therapy KW - Stilbenes -- pharmacology KW - Antineoplastic Agents, Phytogenic -- therapeutic use KW - Stilbenes -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71979526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+%26+lymphoma&rft.atitle=Anti-leukemia+effect+of+resveratrol.&rft.au=Tsan%2C+Min-Fu%3BWhite%2C+Julie+E%3BMaheshwari%2C+Jewraj+G%3BChikkappa%2C+G&rft.aulast=Tsan&rft.aufirst=Min-Fu&rft.date=2002-05-01&rft.volume=43&rft.issue=5&rft.spage=983&rft.isbn=&rft.btitle=&rft.title=Leukemia+%26+lymphoma&rft.issn=10428194&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-11-07 N1 - Date created - 2002-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug hepatotoxicity. AN - 71915977; 12122862 AB - Drug-induced liver disease is a relatively common, but often unrecognized, cause of liver injury, primarily because the diagnosis is often not entertained clinically. In addition, drugs are great imitators, capable of producing nearly any clinical scenario and histopathologic lesion. Thus, when dealing with a liver biopsy from a patient with an undiagnosed liver disease, the diagnosis of drug hepatotoxicity is made by first having a high index of suspicion, and then by careful correlation of histopathologic findings with both clinical and laboratory data and with a search for appropriate precedents in the medical literature. JF - Clinics in liver disease AU - Goodman, Zachary D AD - Division of Hepatic Pathology and the Veterans Administration Special Reference Laboratory for Pathology, Armed Forces Institute of Pathology, Room 3107, 14th Street and Alaska Avenue, NW, Washington, DC 20306, USA. goodman@afip.osd.mil Y1 - 2002/05// PY - 2002 DA - May 2002 SP - 381 EP - 397 VL - 6 IS - 2 SN - 1089-3261, 1089-3261 KW - Index Medicus KW - Hepatitis, Chronic -- pathology KW - Humans KW - Liver -- pathology KW - Chemical and Drug Induced Liver Injury -- etiology KW - Chemical and Drug Induced Liver Injury -- pathology KW - Chemical and Drug Induced Liver Injury -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71915977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+liver+disease&rft.atitle=Drug+hepatotoxicity.&rft.au=Goodman%2C+Zachary+D&rft.aulast=Goodman&rft.aufirst=Zachary&rft.date=2002-05-01&rft.volume=6&rft.issue=2&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Clinics+in+liver+disease&rft.issn=10893261&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-12-19 N1 - Date created - 2002-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Concurrent acute gouty and gonococcal arthritis. AN - 71818077; 12062998 JF - The Lancet. Infectious diseases AU - Lo, Tze Shien AU - Buettner, Ann M AU - Ingebretson, Mark C AD - Infectious Disease Division, Rheumatology Division, and Internal Medicine Department, VA Medical Center, Fargo, ND, USA. tze.lo@med.va.gov Y1 - 2002/05// PY - 2002 DA - May 2002 SP - 313 VL - 2 IS - 5 SN - 1473-3099, 1473-3099 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Gout Suppressants KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Indomethacin -- adverse effects KW - Humans KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Middle Aged KW - Male KW - Gout Suppressants -- therapeutic use KW - Arthritis, Gouty -- microbiology KW - Neisseria gonorrhoeae -- isolation & purification KW - Arthritis, Gouty -- complications KW - Gonorrhea -- drug therapy KW - Arthritis, Gouty -- drug therapy KW - Gonorrhea -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71818077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Lancet.+Infectious+diseases&rft.atitle=Concurrent+acute+gouty+and+gonococcal+arthritis.&rft.au=Lo%2C+Tze+Shien%3BBuettner%2C+Ann+M%3BIngebretson%2C+Mark+C&rft.aulast=Lo&rft.aufirst=Tze&rft.date=2002-05-01&rft.volume=2&rft.issue=5&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=The+Lancet.+Infectious+diseases&rft.issn=14733099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-10 N1 - Date created - 2002-06-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Lancet Infect Dis. 2003 Mar;3(3):177 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Monocyte activation in alcoholic liver disease. AN - 71815641; 12062638 AB - Activated monocytes and macrophages have been postulated to play an important role in the pathogenesis of alcoholic liver disease (ALD). Monocyte activation can be documented by measurement of neopterin, adhesion cell molecules, and certain proinflammatory cytokines and chemokines. We first became interested in the role of monocytes and monocyte-derived cytokines in ALD in relation to altered zinc metabolism that occurs regularly in ALD. Patients with ALD have hypozincemia, which responds poorly to oral zinc supplementation. We have shown that in ALD monocytes make a low-molecular-weight substance that, when injected into rabbits, causes prominent hypozincemia. Subsequently, multiple cytokines [especially tumor necrosis factor (TNF) and interleukin (IL)-8] have been shown to be overproduced by monocytes in ALD. We initially showed that monocytes in ALD spontaneously produce TNF and overproduce TNF in response to a lipopolysaccharide (LPS) stimulus, and this could be attenuated by antioxidants in vitro and in vivo. Alterations in the endotoxin-binding protein LPS-binding protein, in CD14, and in the endotoxin receptor Toll-like receptor 4 all may play roles in enhanced proinflammatory cytokine signaling in ALD. Moreover, several groups have documented increased TNF receptor density in monocytes in ALD. Inadequate negative regulation of TNF occurs at multiple levels in ALD. This includes decreased monocyte production of the important antiinflammatory cytokine IL-10 and blunted response to the antiinflammatory properties of adenosine. Finally, generation of reactive oxygen species (which occurs during alcohol metabolism) and products of lipid peroxidation induce production of cytokines, such as TNF and IL-8. In conclusion, there are multiple overlapping potential mechanisms for enhanced proinflammatory cytokine production by monocytes in ALD. We postulate that activation of monocytes and macrophages with subsequent proinflammatory cytokine production plays an important role in certain metabolic complications of ALD and is a component of the liver injury of ALD. JF - Alcohol (Fayetteville, N.Y.) AU - McClain, Craig J AU - Hill, Daniell B AU - Song, Zhenyuan AU - Deaciuc, Ion AU - Barve, Shirish AD - Department of Medicine, University of Louisville Medical Center and the Veterans Administration, Louisville, KY 40292, USA. craig.mcclain@louisville.edu Y1 - 2002/05// PY - 2002 DA - May 2002 SP - 53 EP - 61 VL - 27 IS - 1 SN - 0741-8329, 0741-8329 KW - Index Medicus KW - Animals KW - Humans KW - Monocytes -- immunology KW - Monocytes -- metabolism KW - Macrophage Activation KW - Liver Diseases, Alcoholic -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71815641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=Monocyte+activation+in+alcoholic+liver+disease.&rft.au=McClain%2C+Craig+J%3BHill%2C+Daniell+B%3BSong%2C+Zhenyuan%3BDeaciuc%2C+Ion%3BBarve%2C+Shirish&rft.aulast=McClain&rft.aufirst=Craig&rft.date=2002-05-01&rft.volume=27&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-11-20 N1 - Date created - 2002-06-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Buprenorphine and addiction: challenges for the pharmacist. AN - 71753930; 12030630 AB - To present an analysis of the Drug Addiction Treatment Act of 2000 (DATA) and its impact on the practice of pharmacy. Statutes, codes, regulations, newspaper articles, journal articles; search of articles posted on MEDLINE identified using the search terms methadone, buprenorphine, treatment, opioid abuse, and opioid addiction. Not applicable. Not applicable. DATA and Food and Drug Administration approval of sublingual tablets of buprenorphine and buprenorphine with naloxone (Reckitt and Benckiser) will dramatically expand opioid addicts' access to treatment and increase the number of opioid addicts receiving prescriptions for buprenorphine and buprenorphine with naloxone. The availability of buprenorphine will pose unique challenges to pharmacists and suggests the need for education on addiction and greater awareness of the unique needs of patients recovering from addiction. The stage is being set to expand access to treatment and reach more untreated opioid addicts in the United States. Professional organizations such as the American Pharmaceutical Association should work with the U.S. Department of Health and Human Services and its Substance Abuse and Mental Health Services Administration to develop training materials, curricula, and guidelines for pharmacists on substance abuse with a special focus on outpatient opioid treatment. Such materials could be used in continuing education programs and materials and in pharmacy schools. JF - Journal of the American Pharmaceutical Association (Washington,D.C. : 1996) AU - Boatwright, Deborah E AD - San Francisco Veterans Affairs Medical Center, Calif, USA. deborah.boatwright@mail.va.gov PY - 2002 SP - 432 EP - 438 VL - 42 IS - 3 SN - 1086-5802, 1086-5802 KW - Analgesics, Opioid KW - 0 KW - Narcotic Antagonists KW - Naloxone KW - 36B82AMQ7N KW - Buprenorphine KW - 40D3SCR4GZ KW - Index Medicus KW - United States KW - Narcotic Antagonists -- therapeutic use KW - Humans KW - Naloxone -- therapeutic use KW - Counseling KW - Buprenorphine -- therapeutic use KW - Analgesics, Opioid -- therapeutic use KW - Opioid-Related Disorders -- rehabilitation KW - Legislation, Drug KW - Pharmacists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71753930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Pharmaceutical+Association+%28Washington%2CD.C.+%3A+1996%29&rft.atitle=Buprenorphine+and+addiction%3A+challenges+for+the+pharmacist.&rft.au=Boatwright%2C+Deborah+E&rft.aulast=Boatwright&rft.aufirst=Deborah&rft.date=2002-05-01&rft.volume=42&rft.issue=3&rft.spage=432&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Pharmaceutical+Association+%28Washington%2CD.C.+%3A+1996%29&rft.issn=10865802&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-24 N1 - Date created - 2002-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Depressive symptomatology and early attrition from intensive outpatient substance use treatment. AN - 71741351; 12032971 AB - This study examines the relationship between depressive symptoms and attrition from outpatient treatment in a Veterans Affairs facility that had recently moved to intensive outpatient-only treatment for substance abuse. This article focuses on 126 consecutively admitted patients who were enrolled on their last day of a 3- to 4-day outpatient detoxification. Results indicate that severe depressive symptomatology presenting at treatment entry is a significant risk factor for early attrition from intensive outpatient substance use treatment but not later attrition. These data indicate that retention efforts should be directed toward the assessment and management of depressive symptoms early in the treatment process, with interventions targeted to those who report severe symptomatology. The results also indicate that future research should focus on potential distinguishing characteristics between early and later attrition. JF - The journal of behavioral health services & research AU - Curran, Geoffrey M AU - Kirchner, JoAnn E AU - Worley, Mark AU - Rookey, Craig AU - Booth, Brenda M AD - Veterans Administration Health Services Research and Development Center for Mental Healthcare and Outcomes Research, Central Arkansas Veterans Healthcare System, 2200 Fort Roots Drive, Building 58, North Little Rock, AR 72114, USA. currangeoffreym@uams.edu Y1 - 2002/05// PY - 2002 DA - May 2002 SP - 138 EP - 143 VL - 29 IS - 2 SN - 1094-3412, 1094-3412 KW - Index Medicus KW - United States KW - United States Department of Veterans Affairs KW - Humans KW - Health Services Research KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - Middle Aged KW - Male KW - Female KW - Hospitals, Veterans KW - Aftercare -- utilization KW - Outpatient Clinics, Hospital -- utilization KW - Patient Dropouts -- statistics & numerical data KW - Mental Health Services -- utilization KW - Substance-Related Disorders -- complications KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Depressive Disorder -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71741351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+behavioral+health+services+%26+research&rft.atitle=Depressive+symptomatology+and+early+attrition+from+intensive+outpatient+substance+use+treatment.&rft.au=Curran%2C+Geoffrey+M%3BKirchner%2C+JoAnn+E%3BWorley%2C+Mark%3BRookey%2C+Craig%3BBooth%2C+Brenda+M&rft.aulast=Curran&rft.aufirst=Geoffrey&rft.date=2002-05-01&rft.volume=29&rft.issue=2&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=The+journal+of+behavioral+health+services+%26+research&rft.issn=10943412&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-13 N1 - Date created - 2002-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The psychopathology, medical management and dental implications of schizophrenia. AN - 71727875; 12036166 AB - Schizophrenia is a psychiatric illness characterized by thought disturbances, bizarre behaviors and cognitive impairments that may diminish a person's abilities in the areas of social relations, school or work and self-care. The onset of the disorder typically occurs between the late teens and mid-30s. Advanced dental disease is seen frequently in patients with schizophrenia for several reasons: the disease impairs these patients' ability to plan and perform oral hygiene procedures; some of the antipsychotic medications they take have adverse orofacial effects such as xerostomia; and these patients sometimes have limited access to treatment because of a paucity of financial resources and adequate number of dentists comfortable in providing care. The recent introduction of more effective medications has permitted the majority of patients to receive their psychiatric care from community-based providers rather than in the hospital. Consequently, dentists in the private sector also are being called on more frequently to care for these people. Dentists cognizant of the signs and symptoms of schizophrenia are likely to feel more secure in treating patients with schizophrenia and more confident when obtaining consultative advice from the patients' psychiatrists. Dentists usually can provide a full range of services to such patients, can enhance these patients' self-esteem and can contribute to the psychotherapeutic aspect of management. To effectively provide treatment to patients with schizophrenia, dentists must be familiar with the disease process so that they can communicate effectively with the patient, the treating psychiatrist and family members who serve as caregivers. In addition, dental treatment may need to be modified because of the patient's impaired ability to think logically, the local and systemic effects of psychiatric medications, and adverse interactions between these drugs and medications used in dentistry. JF - Journal of the American Dental Association (1939) AU - Friedlander, Arthur H AU - Marder, Stephen R AD - VA Greater Los Angeles Healthcare System, Calif 90073, USA. arthur.friedlander@med.va.gov Y1 - 2002/05// PY - 2002 DA - May 2002 SP - 603 EP - 10; quiz 624-5 VL - 133 IS - 5 SN - 0002-8177, 0002-8177 KW - Antipsychotic Agents KW - 0 KW - Dentistry KW - Index Medicus KW - Humans KW - Mouth Diseases -- chemically induced KW - Antipsychotic Agents -- adverse effects KW - Schizophrenia -- drug therapy KW - Schizophrenia -- pathology KW - Dental Care for Chronically Ill UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71727875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dental+Association+%281939%29&rft.atitle=The+psychopathology%2C+medical+management+and+dental+implications+of+schizophrenia.&rft.au=Friedlander%2C+Arthur+H%3BMarder%2C+Stephen+R&rft.aulast=Friedlander&rft.aufirst=Arthur&rft.date=2002-05-01&rft.volume=133&rft.issue=5&rft.spage=603&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dental+Association+%281939%29&rft.issn=00028177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-08-20 N1 - Date created - 2002-05-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Atypical neuroleptic malignant syndrome associated with olanzapine. AN - 71686291; 12013364 AB - Neuroleptic malignant syndrome (NMS) is a potentially life-threatening adverse effect of antipsychotic agents. It generally is characterized by fever, altered mental status, rigidity, and autonomic dysfunction. A 53-year-old man developed NMS without rigidity while taking olanzapine. Such atypical cases may support either a spectrum concept of NMS or the theory that NMS secondary to atypical antipsychotics differs from that caused by conventional neuroleptics. More flexible diagnostic criteria than currently mandated by the the Diagnostic and Statistical Manual of Mental Disorders, Fourth Revision, may be warranted. JF - Pharmacotherapy AU - Reeves, Roy R AU - Torres, Raphael A AU - Liberto, Vincent AU - Hart, Roy H AD - G.V. (Sonny) Montgomery Veterans Administration Medical Center, Jackson, Mississippi 39216, USA. roy.reeves2@med.va.gov Y1 - 2002/05// PY - 2002 DA - May 2002 SP - 641 EP - 644 VL - 22 IS - 5 SN - 0277-0008, 0277-0008 KW - Antipsychotic Agents KW - 0 KW - Benzodiazepines KW - 12794-10-4 KW - Pirenzepine KW - 3G0285N20N KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - Schizophrenia, Paranoid -- drug therapy KW - Humans KW - Hallucinations KW - Schizophrenic Psychology KW - Middle Aged KW - Male KW - Blood Cell Count KW - Schizophrenia, Paranoid -- complications KW - Neuroleptic Malignant Syndrome -- physiopathology KW - Pirenzepine -- analogs & derivatives KW - Antipsychotic Agents -- adverse effects KW - Pirenzepine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71686291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Atypical+neuroleptic+malignant+syndrome+associated+with+olanzapine.&rft.au=Reeves%2C+Roy+R%3BTorres%2C+Raphael+A%3BLiberto%2C+Vincent%3BHart%2C+Roy+H&rft.aulast=Reeves&rft.aufirst=Roy&rft.date=2002-05-01&rft.volume=22&rft.issue=5&rft.spage=641&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-11-05 N1 - Date created - 2002-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationship of treatment orientation and continuing care to remission among substance abuse patients. AN - 71673037; 11986510 AB - The authors examined whether continuing outpatient mental health care, the orientation of the treatment program (12-step, cognitive-behavioral, or eclectic), and involvement in self-help groups were linked to substance abuse patients' remission status two years after discharge. The data were from a cohort of 2,805 male patients who were treated through one of 15 Department of Veterans Affairs substance abuse programs. Remission was defined as abstinence from illicit drug use and abstinence from or nonproblem use of alcohol during the previous three months. The relationships of the three variables to remission were tested with regression models that controlled for baseline characteristics. About a quarter of the study participants (28 percent) were in remission two years after discharge. Intake characteristics that predicted remission at two years included less severe substance use and psychiatric problems, lower expected disadvantages and costs of discontinuing substance use, and having abstinence as a treatment goal. No significant relationship emerged between treatment orientation and remission status two years later. Involvement in outpatient mental health care during the first follow-up year and participation in self-help groups during the last three months of that year were associated with a greater likelihood of remission at the two-year follow-up. The results extend previously published one-year outcome findings showing that cognitive-behavioral and 12-step treatment programs result in similar remission rates. Patients who enter intensive substance abuse treatment with polysubstance use, psychiatric symptoms, or significant emotional distress have more difficulty achieving remission. Routinely engaging patients in continuing outpatient care is likely to yield better outcomes. The duration of such care is probably more important than the number of sessions. JF - Psychiatric services (Washington, D.C.) AU - Ritsher, Jennifer Boyd AU - Moos, Rudolf H AU - Finney, John W AD - Program Evaluation and Resource Center, Veterans Affairs Palo Alto Health Care System, Stanford University School of Medicine, California 94025, USA. jennifer.ritsher@med.va.gov Y1 - 2002/05// PY - 2002 DA - May 2002 SP - 595 EP - 601 VL - 53 IS - 5 SN - 1075-2730, 1075-2730 KW - Street Drugs KW - 0 KW - Index Medicus KW - Humans KW - Adult KW - Treatment Outcome KW - Program Evaluation KW - Follow-Up Studies KW - Time Factors KW - Self-Help Groups KW - Professional-Patient Relations KW - Male KW - Remission Induction KW - Ambulatory Care KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Continuity of Patient Care -- statistics & numerical data KW - Continuity of Patient Care -- standards KW - Substance-Related Disorders -- rehabilitation KW - Mental Health Services -- supply & distribution KW - Mental Health Services -- organization & administration KW - Complementary Therapies -- methods KW - Cognitive Therapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71673037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Relationship+of+treatment+orientation+and+continuing+care+to+remission+among+substance+abuse+patients.&rft.au=Ritsher%2C+Jennifer+Boyd%3BMoos%2C+Rudolf+H%3BFinney%2C+John+W&rft.aulast=Ritsher&rft.aufirst=Jennifer&rft.date=2002-05-01&rft.volume=53&rft.issue=5&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=10752730&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-17 N1 - Date created - 2002-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Urinary free cortisol and childhood trauma in cocaine dependent adults. AN - 71508802; 11886695 AB - To examine whether childhood trauma may have a relationship to hypothalamic-pituitary-adrenal (HPA) axis function as an adult. Forty-six withdrawn cocaine dependent patients participated in 24-h urine collections for determination of urinary-free cortisol (UFC) and completed the Childhood Trauma Questionnaire (CTQ). Patients with a mean UFC output below the median had significantly higher CTQ scores for childhood sexual abuse than patients with UFC outputs above the median. Multiple regression analysis showed that both childhood emotional neglect and sexual abuse were independently associated with UFC outputs. These cross sectional data, in a sample of middle-aged cocaine dependent patients, suggest the possibility that childhood trauma may have an effect on HPA axis function and thus predispose to psychiatric disorders. Further studies are needed in different samples. JF - Journal of psychiatric research AU - Roy, Alec AD - Psychiatry Service 116A, Department of Veterans Affairs, New Jersey Healthcare System, 385 Tremont Avenue, East Orange, NJ 07018, USA. alec.roy@med.va.gov PY - 2002 SP - 173 EP - 177 VL - 36 IS - 3 SN - 0022-3956, 0022-3956 KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Cross-Sectional Studies KW - Risk Factors KW - Humans KW - Adult KW - Child KW - Male KW - Female KW - Hypothalamo-Hypophyseal System -- physiology KW - Cocaine-Related Disorders -- physiopathology KW - Hydrocortisone -- urine KW - Child Abuse KW - Pituitary-Adrenal System -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71508802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychiatric+research&rft.atitle=Urinary+free+cortisol+and+childhood+trauma+in+cocaine+dependent+adults.&rft.au=Roy%2C+Alec&rft.aulast=Roy&rft.aufirst=Alec&rft.date=2002-05-01&rft.volume=36&rft.issue=3&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychiatric+research&rft.issn=00223956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-08 N1 - Date created - 2002-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Do Adolescents Affiliate with 12-Step Groups? A Multivariate Process Model of Effects AN - 61532043; 200301279 AB - Objective: Research with adolescents has revealed salutary effects for 12-step attendance on substance use outcomes, but no studies have examined the effects of 12-step affiliation, or active involvement, beyond simple measures of attendance. Prior research with adults has shown that measures of affiliation are more predictive than measures of attendance. This study (1) assessed attributes that may influence 12-step attendance & affiliation; (2) tested whether 12-step affiliation in the first 3 months posttreatment possessed unique predictive power above that attributable to attendance alone; & (3) examined the extent to which motivation, coping, & self-efficacy measured at 3 months mediated the relation between 12-step affiliation & substance use outcome in the ensuing 3 months. Method: Adolescent inpatients (N = 74, 62% female), who were aged 14-18 years (mean [SD] = 15.9 [1.19] years), were interviewed during treatment & at 3 & 6 months postdischarge. Results: More severely substance-involved youth were more motivated for abstinence & more likely to attend & affiliate with 12-step groups. A high degree of collinearity between 12-step attendance & affiliation suggested that those attending were also likely to be those actively involved. As a consequence, affiliation did not predict outcome over & above frequency of attendance. Motivation was found to influence the relationship between 12-step affiliation & future substance use outcome. Conclusions: Given the widespread treatment recommendations for adolescent 12-step involvement, more study is needed to determine what kinds & what aspects of 12-step groups & fellowships are helpful to adolescent change efforts & what alternatives should be developed. 2 Tables, 2 Figures, 57 References. Adapted from the source document. JF - Journal of Studies on Alcohol AU - Kelly, John F AU - Myers, Mark G AU - Brown, Sandra A AD - Center Health Care Evaluation, Stanford U School Medicine, Menlo Park, CA john.kelly4@med.va.gov Y1 - 2002/05// PY - 2002 DA - May 2002 SP - 293 EP - 304 VL - 63 IS - 3 SN - 0096-882X, 0096-882X KW - Abstinence KW - Treatment Outcomes KW - Substance Abuse KW - Treatment Programs KW - Motivation KW - Treatment Compliance KW - Self Help Groups KW - Group Therapy KW - Treatment Methods KW - Adolescents KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61532043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol&rft.atitle=Do+Adolescents+Affiliate+with+12-Step+Groups%3F+A+Multivariate+Process+Model+of+Effects&rft.au=Kelly%2C+John+F%3BMyers%2C+Mark+G%3BBrown%2C+Sandra+A&rft.aulast=Kelly&rft.aufirst=John&rft.date=2002-05-01&rft.volume=63&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol&rft.issn=0096882X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSALDP N1 - SubjectsTermNotLitGenreText - Self Help Groups; Adolescents; Substance Abuse; Motivation; Treatment Compliance; Treatment Outcomes; Treatment Methods; Treatment Programs; Group Therapy; Abstinence ER - TY - JOUR T1 - Researching Childhood Sexual Abuse: Anticipating Effects on the Researcher AN - 60437965; 200301240 AB - Discusses experiences & coping strategies for psychological researchers of trauma. Self-examination & increased self-awareness are identified as essential components of every phase of a research project. Self-care strategies, coping with avoidance, & journaling are discussed as ways to better "normalize" reactions to traumatic research materials. 9 References. J. W. Parker JF - Feminism & Psychology AU - Stoler, Linda R AD - National Center PTSD, VA Medical Center, Boston, MA stoler.linda@boston.va.gov Y1 - 2002/05// PY - 2002 DA - May 2002 SP - 269 EP - 274 VL - 12 IS - 2 SN - 0959-3535, 0959-3535 KW - Psychological Research KW - Researchers KW - Coping KW - Trauma KW - article KW - 0104: methodology and research technology; research methods/tools UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60437965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Feminism+%26+Psychology&rft.atitle=Researching+Childhood+Sexual+Abuse%3A+Anticipating+Effects+on+the+Researcher&rft.au=Stoler%2C+Linda+R&rft.aulast=Stoler&rft.aufirst=Linda&rft.date=2002-05-01&rft.volume=12&rft.issue=2&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Feminism+%26+Psychology&rft.issn=09593535&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - FEPSFF N1 - SubjectsTermNotLitGenreText - Coping; Psychological Research; Trauma; Researchers ER - TY - JOUR T1 - Adduct formation in DNA as a basis for the establishment of mutational spectra using a novel polymerase termination reaction: an adjunct to the ames test? AN - 71802034; 12062109 JF - Journal of biochemical and biophysical methods AU - Premaratne, Shyamal AD - Department of Veterans Affairs, Hunter Holmes McGuire Veterans Administration Medical Center, Mail Stop 151, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA. spremara@hsc.vcu.edu Y1 - 2002/04/18/ PY - 2002 DA - 2002 Apr 18 SP - 111 EP - 113 VL - 51 IS - 2 SN - 0165-022X, 0165-022X KW - DNA Adducts KW - 0 KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - Time Factors KW - Mutagenicity Tests -- methods KW - Biochemistry -- methods KW - DNA Mutational Analysis KW - DNA-Directed DNA Polymerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71802034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biochemical+and+biophysical+methods&rft.atitle=Adduct+formation+in+DNA+as+a+basis+for+the+establishment+of+mutational+spectra+using+a+novel+polymerase+termination+reaction%3A+an+adjunct+to+the+ames+test%3F&rft.au=Premaratne%2C+Shyamal&rft.aulast=Premaratne&rft.aufirst=Shyamal&rft.date=2002-04-18&rft.volume=51&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Journal+of+biochemical+and+biophysical+methods&rft.issn=0165022X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-19 N1 - Date created - 2002-06-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Outcomes of endoscopy in patients with iron deficiency anemia after Billroth II partial gastrectomy. AN - 85371396; pmid-11907353 AB - To determine the frequency of gastrointestinal lesions detected by upper endoscopy and colonoscopy in patients who developed iron deficiency anemia after Billroth II surgery.The authors reviewed the medical records of 116 consecutive patients with a Billroth II partial gastrectomy and 232 age- and gender-matched controls without gastric surgery who were referred for endoscopy to evaluate iron deficiency anemia over a 5-year period.Clinically important lesions were detected in 22.4% of the patients with gastric surgery and in 59.5% of those with intact stomachs (p < 0.001). In the gastric surgery group, clinically important lesions were found more often in the upper gastrointestinal tract than in the colon (19.0% vs. 3.4%, p < 0.001). In the nonsurgical group, the diagnostic yields of upper endoscopy and colonoscopy were not significantly different (38.4% vs. 32.8%, p = 0.24). Synchronous lesions in the upper and lower gastrointestinal tract were significantly less common in the group of patients with gastric surgery compared with those without gastric surgery (0.0% vs. 11.6%, p < 0.001). Small bowel biopsies and small bowel follow-through did not identify any additional lesions. In the gastric surgery group, multivariate analysis identified abdominal symptoms (OR = 11.2, 95% CI 3.2-39.2, p < 0.001), a positive result on fecal occult blood testing (OR = 6.4, 95% CI 2.0-20.3, p = 0.002), and Billroth II surgery at least 10 years before evaluation (OR = 5.4, 95% CI 1.7-16.7, p = 0.004) as independent predictors of identifying a clinically important lesion by endoscopy.Upper endoscopy had a significantly higher diagnostic yield than colonoscopy in patients who developed iron deficiency anemia after Billroth II surgery. Prospective studies are necessary to determine the role and cost-effectiveness of colonoscopy in the evaluation of iron deficiency anemia in this patient population. JF - Journal of clinical gastroenterology AU - Bini, Edmund J AU - Unger, Jeffrey S AU - Weinshel, Elizabeth H AD - Division of Gastroenterology, VA New York Harbor Healthcare System, Bellevue Hospital, and New York University School of Medicine, New York, New York 10010, USA. Edmund.Bini@med.va.gov Y1 - 2002/04// PY - 2002 DA - Apr 2002 SP - 421 EP - 426 VL - 34 IS - 4 SN - 0192-0790, 0192-0790 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - *Anemia, Iron-Deficiency: diagnosis KW - Anemia, Iron-Deficiency: etiology KW - *Endoscopy, Gastrointestinal KW - Female KW - *Gastrectomy: adverse effects KW - Gastrectomy: methods KW - Gastrointestinal Diseases: complications KW - *Gastrointestinal Diseases: diagnosis KW - Gastrointestinal Hemorrhage: complications KW - Gastrointestinal Hemorrhage: diagnosis KW - Humans KW - Male KW - Middle Aged KW - Occult Blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85371396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+gastroenterology&rft.atitle=Outcomes+of+endoscopy+in+patients+with+iron+deficiency+anemia+after+Billroth+II+partial+gastrectomy.&rft.au=Bini%2C+Edmund+J%3BUnger%2C+Jeffrey+S%3BWeinshel%2C+Elizabeth+H&rft.aulast=Bini&rft.aufirst=Edmund&rft.date=2002-04-01&rft.volume=34&rft.issue=4&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+gastroenterology&rft.issn=01920790&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Aortobronchial fistula: a rare etiology for hemoptysis. AN - 85368658; pmid-11987743 AB - Aortobronchial fistula is an extremely rare cause of hemoptysis. Aortobronchial fistula occurs in patients who have a history of thoracic vascular surgery. Because its symptoms are nonspecific, a high index of suspicion is critical if the physician is to detect it. The results of imaging studies (e.g., plain films, computed tomography, and angiography) and bronchoscopy are sometimes, but not always, diagnostic--another reason the diagnosis is difficult. Left untreated, mortality in patients with aortobronchial fistula is 100%. Patients can be salvaged by a variety of techniques, including the placement of an endovascular stent. We describe the case of a 52-year-old man who came to us with hoarseness and hemoptysis, which proved to be underlying symptoms of aortobronchial fistula. He was treated successfully. JF - Ear, nose, & throat journal AU - Oppenheimer, Randy AU - Brotherton, Lawrence AD - Department of Surgery, Carl T. Hayden VA Medical Center, 650 E. Indian School Rd., Phoenix, AZ 85012, USA. randy.oppenheimer@med.va.gov Y1 - 2002/04// PY - 2002 DA - Apr 2002 SP - 257 EP - 259 VL - 81 IS - 4 SN - 0145-5613, 0145-5613 KW - Index Medicus KW - National Library of Medicine KW - *Aortic Diseases: complications KW - Aortic Diseases: surgery KW - *Bronchial Neoplasms: complications KW - Bronchial Neoplasms: surgery KW - *Hemoptysis: etiology KW - Humans KW - Male KW - Middle Aged KW - *Vascular Fistula: complications KW - Vascular Fistula: surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85368658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear%2C+nose%2C+%26+throat+journal&rft.atitle=Aortobronchial+fistula%3A+a+rare+etiology+for+hemoptysis.&rft.au=Oppenheimer%2C+Randy%3BBrotherton%2C+Lawrence&rft.aulast=Oppenheimer&rft.aufirst=Randy&rft.date=2002-04-01&rft.volume=81&rft.issue=4&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Ear%2C+nose%2C+%26+throat+journal&rft.issn=01455613&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Aluminum neurotoxicity is reduced by dantrolene and dimethyl sulfoxide in cultured rat hippocampal neurons. AN - 71670440; 12002663 AB - Cell death was reduced in cultured rat hippocampal cells treated with aluminum chloride by dantrolene and dimethylsulfoxide, indicating aluminum toxicity may be mediated through release of calcium from intracellular stores and oxidative stress. Cell death was reduced to a lesser degree by cycloheximide and actinomycin D, indicating some evidence for apoptosis, however apoptosis did not appear to be a major cause of cell death from aluminum toxicity. JF - Biological trace element research AU - Brenner, Steven AD - Department of Neurology, St. Louis Veterans Administration Medical Center, MO 63106, USA. Y1 - 2002/04// PY - 2002 DA - April 2002 SP - 85 EP - 89 VL - 86 IS - 1 SN - 0163-4984, 0163-4984 KW - Aluminum KW - CPD4NFA903 KW - Dantrolene KW - F64QU97QCR KW - Calcium KW - SY7Q814VUP KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Index Medicus KW - Rats KW - Calcium -- metabolism KW - Animals KW - Rats, Sprague-Dawley KW - Oxidative Stress KW - Apoptosis -- drug effects KW - Hippocampus -- drug effects KW - Dimethyl Sulfoxide -- pharmacology KW - Dantrolene -- pharmacology KW - Neurons -- drug effects KW - Aluminum -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71670440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+trace+element+research&rft.atitle=Aluminum+neurotoxicity+is+reduced+by+dantrolene+and+dimethyl+sulfoxide+in+cultured+rat+hippocampal+neurons.&rft.au=Brenner%2C+Steven&rft.aulast=Brenner&rft.aufirst=Steven&rft.date=2002-04-01&rft.volume=86&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Biological+trace+element+research&rft.issn=01634984&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-24 N1 - Date created - 2002-05-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phenylpropanolamine appears not to promote weight loss in patients with schizophrenia who have gained weight during clozapine treatment. AN - 71667381; 12000209 AB - Weight gain is a common side effect of clozapine treatment and may expose patients to obesity-associated health risks. We proposed that concomitant treatment with an appetite suppressant such as phenylpropanolamine (PPA) would lead to a decrease in appetite and therefore loss of weight. This was a 12-week, double-blind, randomized, placebo-controlled trial of PPA, 75 mg/day, in outpatients with treatment-refractory schizophrenia (DSM-IV) who were stable on clozapine treatment for at least 4 months and had gained > 10% of their baseline body weight since starting clozapine. Patients were evaluated for adverse effects and weighed weekly. A Positive and Negative Syndrome Scale (PANSS) assessment, a short dietary quiz, and blood indices were completed monthly. Sixteen patients were equally randomly assigned to receive PPA or placebo. The groups did not differ in mean age, baseline weight, dose of clozapine, baseline PANSS scores, or the percent of weight gained since the start of clozapine. There was no significant effect of treatment on weight (t = 0.219, df = 10, p = .831). There was no significant change in either the total PANSS scores (t = -0.755, df = 10, p = .468), the positive or negative symptom cluster scores, or any of the remaining variables. Phenylpropanolamine 75 mg/day was well tolerated but was not effective in reversing established weight gain associated with clozapine treatment in stable outpatients with schizophrenia. JF - The Journal of clinical psychiatry AU - Borovicka, Mary C AU - Fuller, Matthew A AU - Konicki, P Eric AU - White, John C AU - Steele, Vickie M AU - Jaskiw, George E AD - Louis Stokes Cleveland Veterans Administration Medical Center, Ohio 44141, USA. Y1 - 2002/04// PY - 2002 DA - April 2002 SP - 345 EP - 348 VL - 63 IS - 4 SN - 0160-6689, 0160-6689 KW - Antipsychotic Agents KW - 0 KW - Appetite Depressants KW - Delayed-Action Preparations KW - Placebos KW - Phenylpropanolamine KW - 33RU150WUN KW - Clozapine KW - J60AR2IKIC KW - Index Medicus KW - Drug Administration Schedule KW - Double-Blind Method KW - Humans KW - Pilot Projects KW - Research Design KW - Ambulatory Care KW - Psychiatric Status Rating Scales KW - Adult KW - Weight Loss -- drug effects KW - Treatment Outcome KW - Female KW - Male KW - Obesity -- drug therapy KW - Weight Gain -- drug effects KW - Obesity -- prevention & control KW - Clozapine -- therapeutic use KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenia -- diagnosis KW - Schizophrenia -- drug therapy KW - Phenylpropanolamine -- therapeutic use KW - Clozapine -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Obesity -- chemically induced KW - Appetite Depressants -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71667381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Phenylpropanolamine+appears+not+to+promote+weight+loss+in+patients+with+schizophrenia+who+have+gained+weight+during+clozapine+treatment.&rft.au=Borovicka%2C+Mary+C%3BFuller%2C+Matthew+A%3BKonicki%2C+P+Eric%3BWhite%2C+John+C%3BSteele%2C+Vickie+M%3BJaskiw%2C+George+E&rft.aulast=Borovicka&rft.aufirst=Mary&rft.date=2002-04-01&rft.volume=63&rft.issue=4&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-05-31 N1 - Date created - 2002-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of nitric oxide in inflammatory conditions. AN - 71613923; 11961394 AB - Nitric oxide (NO) plays an important regulatory/modulatory role in a variety of inflammatory conditions. NO is a small, short-lived molecule that is released from a variety of cells in response to homeostatic and pathologic stimuli. It may act as a vasodilator and a platelet inhibitor and may interfere with adhesion molecules to prevent neutrophil adhesion. NO release may also lead to the formation of highly reactive species such as peroxynitrite and stable nitrosothiols and may cause mitochondrial damage and nitration of protein tyrosine residues. In addition, NO inhibits cell proliferation via inhibition of polyamine synthesis and cell uptake and may well act as a 'brake' on the proliferative response following cytokine exposure. All three isoforms of nitric oxide synthases are found in the kidney during inflammation. The site of NO release impacts significantly on its net function and structural impact. NO plays a protective role in many forms of immune injury, such as nephrotoxic serum-induced glomerulonephritis, autoimmune tubular interstitital nephritis, and experimental allergic encephalomyelitis. NO overproduction in sepsis, after cytokine exposure, inducible NO synthase transcription, and local inflammation can autoinhibit endothelial NO synthase, leading to selective renal and mesenteric vasoconstriction. Copyright 2002 S. Karger AG, Basel JF - Nephron AU - Blantz, Roland C AU - Munger, Karen AD - University of California, Veterans Administration Sand Diego Healthcare System, USA. rblantz@ucsd.edu Y1 - 2002/04// PY - 2002 DA - April 2002 SP - 373 EP - 378 VL - 90 IS - 4 SN - 1660-8151, 1660-8151 KW - Cytokines KW - 0 KW - Isoenzymes KW - Nitric Oxide KW - 31C4KY9ESH KW - Arginine KW - 94ZLA3W45F KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Ornithine Decarboxylase KW - EC 4.1.1.17 KW - Index Medicus KW - Ornithine Decarboxylase -- metabolism KW - Animals KW - Glomerulonephritis -- metabolism KW - Arginine -- metabolism KW - Humans KW - Cell Division -- physiology KW - Encephalomyelitis, Autoimmune, Experimental -- metabolism KW - Nephritis, Interstitial -- metabolism KW - Cytokines -- metabolism KW - Sepsis -- metabolism KW - Inflammation -- physiopathology KW - Kidney -- pathology KW - Kidney -- enzymology KW - Nitric Oxide -- metabolism KW - Nitric Oxide Synthase -- metabolism KW - Kidney -- physiopathology KW - Isoenzymes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71613923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nephron&rft.atitle=Role+of+nitric+oxide+in+inflammatory+conditions.&rft.au=Blantz%2C+Roland+C%3BMunger%2C+Karen&rft.aulast=Blantz&rft.aufirst=Roland&rft.date=2002-04-01&rft.volume=90&rft.issue=4&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Nephron&rft.issn=16608151&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-11-20 N1 - Date created - 2002-04-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hyperlipidemia in HIV-positive patients receiving antiretrovirals. AN - 71551276; 11918504 AB - To assess the frequency of lipid abnormalities and treatment outcomes for hyperlipidemia in HIV-positive patients receiving antiretroviral (ARV) therapy as outpatients at a Veterans Affairs HIV clinic. All patients monitored for at least 3 months were reviewed. Data collected included age, most recent CD4+ cell count and viral load, ARV history, and all fasting cholesterol, triglyceride, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) values. The ARV therapy at the time of lipid readings was classified as including protease inhibitors (PI+) or not including them (PI-). Lipid values were compared with goals per national guidelines and risk factors. Male patients (n = 101) providing 210 lipid profiles were evaluated (median 2 per patient). Median age was 51 years. Fourteen patients were diabetic, 31 were hypertensive, and 6 patients had documented coronary disease. Mean cholesterol, triglycerides, and LDL values were significantly higher in PI+ (n = 50) compared with those of PI- patients (n = 51; p < 0.05). HDL values were not different between groups. Significantly more PI+ patients had lipid concentrations above recommended goals compared with PI- patients (17 vs. 7; p = 0.04). Six patients achieved lipid goals after following a low-fat diet (4 PI+). Fifteen subjects (11 PI+) were being treated with medications. Ten patients (67%) reached lipid goals, 2 had not reached goals (13%), and 3 (20%) were undergoing medication titration. Our HIV-infected patients had significantly higher cholesterol, triglyceride, and LDL values when PI+. In contrast to other reports, the majority of patients treated for lipid abnormalities achieved treatment goals. JF - The Annals of pharmacotherapy AU - Segarra-Newnham, Marisel AD - Infectious Diseases, Veterans Affairs Medical Center, 7305 N. Military Trail, West Palm Beach, FL 33410-6400, USA. marisel.segarra-newnham@med.va.gov Y1 - 2002/04// PY - 2002 DA - April 2002 SP - 592 EP - 595 VL - 36 IS - 4 SN - 1060-0280, 1060-0280 KW - Cholesterol, HDL KW - 0 KW - Cholesterol, LDL KW - HIV Protease Inhibitors KW - Hypolipidemic Agents KW - Index Medicus KW - Viral Load KW - Cholesterol, LDL -- blood KW - Hypolipidemic Agents -- therapeutic use KW - Cholesterol, HDL -- blood KW - Humans KW - Retrospective Studies KW - Antiretroviral Therapy, Highly Active KW - Middle Aged KW - CD4 Lymphocyte Count KW - Male KW - Hyperlipidemias -- chemically induced KW - HIV Infections -- drug therapy KW - Hyperlipidemias -- drug therapy KW - HIV Protease Inhibitors -- adverse effects KW - Hyperlipidemias -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71551276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Hyperlipidemia+in+HIV-positive+patients+receiving+antiretrovirals.&rft.au=Segarra-Newnham%2C+Marisel&rft.aulast=Segarra-Newnham&rft.aufirst=Marisel&rft.date=2002-04-01&rft.volume=36&rft.issue=4&rft.spage=592&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-24 N1 - Date created - 2002-03-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Double-blind, placebo-controlled study of single-dose metergoline in depressed patients with seasonal affective disorder. AN - 71538719; 11910270 AB - A role for serotonin in season affective disorder (SAD) has been explored with a variety of serotonergic pharmacologic agents. The authors initially hypothesized that metergoline, a nonspecific serotonin antagonist, would exacerbate depressive symptoms. In a small, open-label pilot study, the authors observed the opposite effect. They decided to follow up on this finding with this formal study. The study followed a double-blind, randomized cross-over design. Sixteen untreated, depressed patients with SAD received single oral doses of metergoline 8 mg and of placebo, spaced 1 week apart. Fourteen patients were restudied after 2 weeks of light treatment. Depression ratings using the Structured Interview Guide for the Hamilton Depression Rating Scale-Seasonal Affective Disorder Version were performed at baseline and at 3 and 6 days after each intervention. These data were analyzed by baseline-corrected repeated measures with analysis of variance. In the off-lights condition, severity of depression was diminished after metergoline compared with placebo administration (p = 0.001). Patient daily self-ratings suggested that the peak effect occurred 2 to 4 days after study drug administration. In contrast, after 2 weeks of treatment with bright artificial light, metergoline did not demonstrate a significant effect on mood. These data suggest that single doses of metergoline may have antidepressant effects that last several days. Possible mechanisms include 5-hydroxytryptamine(2) receptor downregulation and dopamine agonism. JF - Journal of clinical psychopharmacology AU - Turner, Erick H AU - Schwartz, Paul J AU - Lowe, Catherine H AU - Nawab, Stefan S AU - Feldman-Naim, Susana AU - Drake, Christopher L AU - Myers, Frances S AU - Barnett, Ronald L AU - Rosenthal, Norman E AD - Section on Biological Rhythms, Intramural Research Program, National Institute of Mental Health, Bethesda, Maryland, USA. Erick.Turner@med.va.gov Y1 - 2002/04// PY - 2002 DA - April 2002 SP - 216 EP - 220 VL - 22 IS - 2 SN - 0271-0749, 0271-0749 KW - Antidepressive Agents KW - 0 KW - Dopamine Agonists KW - Receptors, Serotonin KW - Serotonin Antagonists KW - Metergoline KW - 1501393LY5 KW - Index Medicus KW - Receptors, Serotonin -- drug effects KW - Double-Blind Method KW - Combined Modality Therapy KW - Humans KW - Dopamine Agonists -- adverse effects KW - Adult KW - Cross-Over Studies KW - Middle Aged KW - Dopamine Agonists -- administration & dosage KW - Down-Regulation -- drug effects KW - Phototherapy KW - Female KW - Male KW - Seasonal Affective Disorder -- drug therapy KW - Metergoline -- adverse effects KW - Depressive Disorder, Major -- diagnosis KW - Depressive Disorder, Major -- drug therapy KW - Seasonal Affective Disorder -- diagnosis KW - Serotonin Antagonists -- administration & dosage KW - Depressive Disorder, Major -- psychology KW - Seasonal Affective Disorder -- psychology KW - Antidepressive Agents -- therapeutic use KW - Serotonin Antagonists -- adverse effects KW - Antidepressive Agents -- adverse effects KW - Metergoline -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71538719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Double-blind%2C+placebo-controlled+study+of+single-dose+metergoline+in+depressed+patients+with+seasonal+affective+disorder.&rft.au=Turner%2C+Erick+H%3BSchwartz%2C+Paul+J%3BLowe%2C+Catherine+H%3BNawab%2C+Stefan+S%3BFeldman-Naim%2C+Susana%3BDrake%2C+Christopher+L%3BMyers%2C+Frances+S%3BBarnett%2C+Ronald+L%3BRosenthal%2C+Norman+E&rft.aulast=Turner&rft.aufirst=Erick&rft.date=2002-04-01&rft.volume=22&rft.issue=2&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-05-13 N1 - Date created - 2002-03-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Physiology of sulfide in the rat colon: use of bismuth to assess colonic sulfide production. AN - 71535273; 11896034 AB - Colonic bacteria produce hydrogen sulfide, a toxic compound postulated to play a pathogenetic role in ulcerative colitis. Colonic sulfide exposure has previously been assessed via measurements of fecal sulfide concentration. However, we found that <1% of fecal sulfide of rats was free, the remainder being bound in soluble and insoluble complexes. Thus fecal sulfide concentrations may reflect sulfide binding capacity rather than the toxic potential of feces. We utilized bismuth subnitrate to quantitate intracolonic sulfide release based on observations that bismuth 1) avidly binds sulfide; 2) quantitatively releases bound sulfide when acidified; and 3) does not influence fecal sulfide production by fecal homogenates. Rats ingesting bismuth subnitrate excreted 350 +/- 18 micromol/day of fecal sulfide compared with 9 +/- 1 micromol/day in control rats. Thus the colon normally absorbs approximately 340 micromol of sulfide daily, a quantity that would produce local and systemic injury if not efficiently detoxified by the colonic mucosa. Studies utilizing bismuth should help to clarify the factors influencing sulfide production in the human colon. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Levitt, Michael D AU - Springfield, John AU - Furne, Julie AU - Koenig, Thomas AU - Suarez, Fabrizis L AD - Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA. Michael.Levitt@med.va.gov Y1 - 2002/04// PY - 2002 DA - April 2002 SP - 1655 EP - 1660 VL - 92 IS - 4 SN - 8750-7587, 8750-7587 KW - Antacids KW - 0 KW - Sulfur Radioisotopes KW - bismuth subnitrate KW - H19J064BA5 KW - Bismuth KW - U015TT5I8H KW - Hydrogen Sulfide KW - YY9FVM7NSN KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Animal Feed KW - Cecum -- drug effects KW - Intestinal Mucosa -- metabolism KW - Intestinal Mucosa -- drug effects KW - Feces KW - Male KW - Cecum -- metabolism KW - Bismuth -- pharmacology KW - Antacids -- pharmacology KW - Hydrogen Sulfide -- metabolism KW - Colon -- metabolism KW - Colon -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71535273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Physiology+of+sulfide+in+the+rat+colon%3A+use+of+bismuth+to+assess+colonic+sulfide+production.&rft.au=Levitt%2C+Michael+D%3BSpringfield%2C+John%3BFurne%2C+Julie%3BKoenig%2C+Thomas%3BSuarez%2C+Fabrizis+L&rft.aulast=Levitt&rft.aufirst=Michael&rft.date=2002-04-01&rft.volume=92&rft.issue=4&rft.spage=1655&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-08 N1 - Date created - 2002-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - SPHINGOSINE-1-PHOSPHATE STIMULATES HUMAN CACO-2 INTESTINAL EPITHELIAL PROLIFERATION VIA p38 ACTIVATION AND ACTIVATES ERK BY AN INDEPENDENT MECHANISM AN - 19337331; 8696188 AB - Sphingosine-1-phosphate (S-1-P) has been identified as an extracellular mediator and an intracellular second messenger that may modulate cell motility, adhesion, proliferation, and differentiation and cancer cell invasion. Widely distributed, S-1-P is most abundant in the intestine. Although S-1-P is likely to modulate various intracellular pathways, activation of the mitogen-activated protein kinases (MAPKs) such as extracellular signal-regulated kinase 1 (ERK1), ERK2, and p38 is among the best-characterized S-1-P effects. Because the MAPKs regulate proliferation, we hypothesized that S-1-P might stimulate intestinal epithelial cell proliferation by MAPK activation. Human Caco-2 intestinal epithelial cells were cultured on a fibronectin matrix because fibronectin is an important constituent of the gut mucosal basement membrane. We assessed ERK1, ERK2, and p38 activation by Western blotting with antibodies specific for their active forms and proliferation by Coulter counting at 24 h. Specific MAP kinase kinase (MEK) and p38 inhibitors PD98059 (20 mu M) and SB202190 and SB203580 (10 and 20 mu M) were used to probe the role of ERK and p38 in S-1-P-mediated proliferation. Three or more similar studies were pooled for the analysis. S-1-P stimulated Caco-2 proliferation and dose-responsively activated ERK1, ERK2, and p38. Proliferation peaked at 5 mu M, yielding a cell number 166.3 plus or minus 2.7% of the vehicle control (n = 6, P < 0.05). S-1-P also maximally stimulated ERK1, ERK2, and p38 at 5 mu M, to 164.4 plus or minus 19.9%, 232.2 plus or minus 38.5%, and 169.2 plus or minus 20.5% of the control, respectively. Although MEK inhibition prevented S-1-P activation of ERK1 and ERK2 and slightly but significantly inhibited basal Caco-2 proliferation, MEK inhibition did not block the S-1-P mitogenic effect. However, pretreatment with 10 mu M SB202190 or SB203580 (putative p38 inhibitors) attenuated the stimulation of proliferation by S-1-P. Twenty micromolars of SB202190 or SB203580 completely blocked the mitogenic effect of S-1-P. Ten to twenty micromolars of SB202190 and SB203580 also dose-dependently ablated the effects of 5 mu M S-1-P on heat shock protein 27 accumulation, a downstream consequence of p38 MAPK activation. Consistent with the reports in some other cell types, S-1-P appears to activate ERK1, ERK2, and p38 and to stimulate proliferation. However, in contrast to the mediation of the S-1-P effects in some other cell types, S-1-P appears to stimulate human intestinal epithelial proliferation by activating p38. ERK activation by S-1-P is not required for its mitogenic effect. JF - In Vitro Cellular & Developmental Biology - Animal AU - Thamilselvan, Vijayalakshmi AU - Li, Wei AU - Sumpio, Bauer E AU - Basson, Marc D AD - Department of Surgery, Wayne State University, Detroit, Michigan 48202 (V. T., M. D. B.), Department of Surgery, John D. Dingell VA Medical Center, 4646 John R. Street, Detroit, Michigan 48201-1932 (V. T., M. D. B.), Department of Surgery, Yale University, New Haven, Connecticut 06520 (W. L., B. E. S.), Department of Surgery, Tianjin Medical University Cancer Hospital, People's Republic of China (W. L.), and Department of Surgery, West Haven VA Hospital, West Haven, CT (B. E. S.), Marc.Basson@med.va.gov Y1 - 2002/04// PY - 2002 DA - Apr 2002 SP - 246 EP - 253 PB - Allen Press, Inc., 810 East Tenth St. VL - 38 IS - 4 SN - 1071-2690, 1071-2690 KW - Biotechnology and Bioengineering Abstracts KW - intestinal epithelium KW - signal transduction KW - sphingosine-1-phosphate KW - ERK KW - p38 KW - Western blotting KW - Epithelial cells KW - MAP kinase KW - Cell number KW - Fibronectin KW - Mucosa KW - Probes KW - Sphingosine 1-phosphate KW - Enumeration KW - Cancer KW - Extracellular signal-regulated kinase KW - Differentiation KW - MAP kinase kinase KW - Second messengers KW - Antibodies KW - Digestive tract KW - Basement membranes KW - Hsp27 protein KW - Intestine KW - Cell migration KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19337331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.atitle=SPHINGOSINE-1-PHOSPHATE+STIMULATES+HUMAN+CACO-2+INTESTINAL+EPITHELIAL+PROLIFERATION+VIA+p38+ACTIVATION+AND+ACTIVATES+ERK+BY+AN+INDEPENDENT+MECHANISM&rft.au=Thamilselvan%2C+Vijayalakshmi%3BLi%2C+Wei%3BSumpio%2C+Bauer+E%3BBasson%2C+Marc+D&rft.aulast=Thamilselvan&rft.aufirst=Vijayalakshmi&rft.date=2002-04-01&rft.volume=38&rft.issue=4&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.issn=10712690&rft_id=info:doi/10.1290%2F1071-2690%282002%290382.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Western blotting; MAP kinase; Cell number; Fibronectin; Mucosa; Probes; Sphingosine 1-phosphate; Enumeration; Cancer; MAP kinase kinase; Differentiation; Extracellular signal-regulated kinase; Antibodies; Second messengers; Digestive tract; Basement membranes; Hsp27 protein; Intestine; Cell migration DO - http://dx.doi.org/10.1290/1071-2690(2002)038<0246:SPSHCI>2.0.CO;2 ER - TY - JOUR T1 - In Vitro and In Vivo Activities of Gatifloxacin against Mycobacterium tuberculosis AN - 18366403; 5339628 AB - Gatifloxacin (GAT) and moxifloxacin (MXF) were evaluated in vitro to determine their activities against Mycobacterium tuberculosis. GAT was subsequently compared in a dose range study to isoniazid (INH) in a murine tuberculosis model. GAT was somewhat less active than INH. GAT and MXF were evaluated in mice infected with M. tuberculosis and were found to have similar activities. GAT was studied alone and in combination with ethambutol, ethionamide (ETA), and pyrazinamide (PZA) and compared to INH and rifampin (RIF). GAT appears to have sufficient activity alone and in combination with ETA with or without PZA to merit evaluation for treatment of tuberculosis. JF - Antimicrobial Agents & Chemotherapy AU - Alvirez-Freites, EJ AU - Carter, J L AU - Cynamon, M H AD - VAMC, 800 Irving Ave., Syracuse, NY 13210., Michael.Cynamon@med.va.gov Y1 - 2002/04// PY - 2002 DA - Apr 2002 SP - 1022 EP - 1025 VL - 46 IS - 4 SN - 0066-4804, 0066-4804 KW - mice KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - J 02793:Antibiotics: Others KW - A 01095:Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18366403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+Vitro+and+In+Vivo+Activities+of+Gatifloxacin+against+Mycobacterium+tuberculosis&rft.au=Alvirez-Freites%2C+EJ%3BCarter%2C+J+L%3BCynamon%2C+M+H&rft.aulast=Alvirez-Freites&rft.aufirst=EJ&rft.date=2002-04-01&rft.volume=46&rft.issue=4&rft.spage=1022&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.46.4.1022-1025.2002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1128/AAC.46.4.1022-1025.2002 ER - TY - JOUR T1 - Antibodies against a Synthetic Peptide of SagA Neutralize the Cytolytic Activity of Streptolysin S from Group A Streptococci AN - 18281113; 5332757 AB - Virtually all group A streptococci (GAS) produce streptolysin S (SLS), a cytolytic toxin that is responsible for the beta-hemolysis surrounding colonies of the organisms grown on blood agar. SLS is an important virulence determinant of GAS, and recent studies have identified a nine-gene locus that is responsible for synthesis and transport of the toxin. SLS is not immunogenic; thus, no neutralizing antibodies are evoked during the course of natural infection. In the present study, we show that a synthetic peptide containing amino acid residues 10 to 30 of the putative SLS (SagA) propeptide [SLS(10-30)] coupled to keyhole limpet hemocyanin evoked antibodies in rabbits that completely neutralized the hemolytic activity of the toxin in vitro. Inhibition of hemolysis was reversed by preincubation of the immune serum with soluble, unconjugated peptide, indicating the specificity of the antibodies. In addition, antibodies that were affinity purified over an SLS(10-30) peptide column completely inhibited SLS-mediated hemolysis. The SLS(10-30) antisera did not opsonize group A streptococci; however, when combined with type-specific M protein antisera, the SLS antibodies significantly enhanced phagocytosis mediated by M protein antibodies. Thus, we have shown for the first time that it is possible to raise neutralizing antibodies against one of the most potent bacterial cytolytic toxins known. Our data also provide convincing evidence that the sagA gene actually encodes the SLS peptide of GAS. The synthetic peptide may prove to be an important component of vaccines designed to prevent GAS infections. JF - Infection and Immunity AU - Dale, J B AU - Chiang, E Y AU - Hasty, D L AU - Courtney, H S AD - VA Medical Center (11A), 1030 Jefferson Ave., Memphis, TN 38104., james.dale@med.va.gov Y1 - 2002/04// PY - 2002 DA - Apr 2002 SP - 2166 EP - 2170 VL - 70 IS - 4 SN - 0019-9567, 0019-9567 KW - man KW - streptococci KW - SagA protein KW - streptolysin S KW - Immunology Abstracts; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Antisera KW - Vaccines KW - Antibody response KW - Toxins KW - Streptococcus pyogenes KW - F 06807:Active immunization KW - G 07320:Bacterial genetics KW - J 02823:In vitro and in vivo effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18281113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Antibodies+against+a+Synthetic+Peptide+of+SagA+Neutralize+the+Cytolytic+Activity+of+Streptolysin+S+from+Group+A+Streptococci&rft.au=Dale%2C+J+B%3BChiang%2C+E+Y%3BHasty%2C+D+L%3BCourtney%2C+H+S&rft.aulast=Dale&rft.aufirst=J&rft.date=2002-04-01&rft.volume=70&rft.issue=4&rft.spage=2166&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.70.4.2166-2170.2002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pyogenes; Streptococcus; Toxins; Antibody response; Vaccines; Antisera DO - http://dx.doi.org/10.1128/IAI.70.4.2166-2170.2002 ER - TY - JOUR T1 - Immunogenicity of a 26-Valent Group A Streptococcal Vaccine AN - 18276567; 5332791 AB - A multivalent vaccine containing amino-terminal M protein fragments from 26 different serotypes of group A streptococci was constructed by recombinant techniques. The vaccine consisted of four different recombinant proteins that were formulated with alum to contain 400 mu g of protein per dose. Rabbits were immunized via the intramuscular route at 0, 4, and 16 weeks. Immune sera were assayed for the presence of type-specific antibodies against the individual recombinant M peptides by enzyme-linked immunosorbent assay and for opsonic antibodies by in vitro opsonization tests and indirect bactericidal tests. The 26-valent vaccine was highly immunogenic and elicited fourfold or greater increases in antibody levels against 25 of the 26 serotypes represented in the vaccine. The immune sera were broadly opsonic and were bactericidal against the majority of the 26 different serotypes. Importantly, none of the immune sera cross-reacted with human tissues. Our results indicate that type-specific, protective M protein epitopes can be incorporated into complex, multivalent vaccines designed to elicit broadly protective opsonic antibodies in the absence of tissue-cross-reactive antibodies. JF - Infection and Immunity AU - Hu, M C AU - Walls, MA AU - Stroop, S D AU - Reddish, MA AU - Beall, B AU - Dale, J B AD - VA Medical Center (11A), University of Tennessee, 1030 Jefferson Ave., Memphis, TN 38104., james.dale@med.va.gov Y1 - 2002/04// PY - 2002 DA - Apr 2002 SP - 2171 EP - 2177 VL - 70 IS - 4 SN - 0019-9567, 0019-9567 KW - immunogenicity KW - man KW - double prime M protein KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - M protein KW - ^AM protein KW - Enzyme-linked immunosorbent assay KW - Antibody response KW - Vaccines KW - J 02834:Vaccination and immunization KW - F 06807:Active immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18276567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Immunogenicity+of+a+26-Valent+Group+A+Streptococcal+Vaccine&rft.au=Hu%2C+M+C%3BWalls%2C+MA%3BStroop%2C+S+D%3BReddish%2C+MA%3BBeall%2C+B%3BDale%2C+J+B&rft.aulast=Hu&rft.aufirst=M&rft.date=2002-04-01&rft.volume=70&rft.issue=4&rft.spage=2171&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.70.4.2171-2177.2002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Vaccines; Enzyme-linked immunosorbent assay; Antibody response DO - http://dx.doi.org/10.1128/IAI.70.4.2171-2177.2002 ER - TY - JOUR T1 - Accelerated superfractionated radiotherapy with concomitant boost for locally advanced head-and-neck squamous cell carcinomas. AN - 71619291; 11958884 AB - A growing body of evidence supports the efficacy of accelerated superfractionated radiotherapy with concomitant boost for advanced head-and-neck carcinomas. This study represents a single-institution experience, performed to identify the factors influencing tumor control, survival, and toxicity. Between 1988 and 1999, 133 patients with primary squamous cell head-and-neck carcinoma underwent accelerated superfractionated radiotherapy using a concomitant boost. The concomitant boost in this regimen was delivered using reduced fields delivered 3 times weekly in a twice-daily schedule during the final phase. The total radiation dose ranged from 64.8 Gy to 76.5 Gy (mean 71.1). Patients were evaluated in follow-up for local control and late toxicity. Multivariate analysis of treatment and patient parameters was performed to evaluate their influence on toxicity, local control, and overall survival. With a mean follow-up of 37 months, the actuarial overall survival rate for the entire group at 5 years was 24% and the local control rate was 57%. The tumor volume was the most significant predictor of local control, such that each 1-cm(3) increase in volume was associated with a 1% decrease in local control. For patients with tumor volumes 30 cm(3), the 5-year disease-specific survival rate was 52% and 27% (p = 0.004) and locoregional control rate was 76% and 26% (p <0.001), respectively. Seventy-six patients with a minimum of 12 months and median of 39 months toxicity follow-up were studied for late effects. None of these patients experienced Grade 4 or 5 toxicity. The actuarial rate of significant toxicity (Grade III or greater) was 32% at 5 years. Of the toxicities observed, xerostomia (19%) was the most common. Multivariate analysis revealed N stage and dose as independent predictors of Grade 3 effects. The locoregional control and survival for patients in this institutional experience compare favorably to other published reports. Tumors of the larynx had the best prognosis. Larger volume tumors were associated with significantly lower local control and survival. Significant late effects were related to dose and nodal status. JF - International journal of radiation oncology, biology, physics AU - Morris, Monica M AU - Schmidt-Ullrich, Rupert K AU - DiNardo, L AU - Manning, Matthew A AU - Silverman, L AU - Clay, L AU - Johnson, Christopher R AU - Amir, Cyrus AD - Department of Radiation Oncology, Medical College of Virginia Hospitals and Hunter Holmes McGuire Veterans Administration Medical Center, Virginia Commonwealth University, Richmond, VA, USA. mmmorris@hsc.vcu.edu Y1 - 2002/03/15/ PY - 2002 DA - 2002 Mar 15 SP - 918 EP - 928 VL - 52 IS - 4 SN - 0360-3016, 0360-3016 KW - Index Medicus KW - Analysis of Variance KW - Prospective Studies KW - Survival Rate KW - Neoplasm Staging KW - Humans KW - Middle Aged KW - Follow-Up Studies KW - Time Factors KW - Male KW - Female KW - Proportional Hazards Models KW - Dose Fractionation KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- mortality KW - Head and Neck Neoplasms -- radiotherapy KW - Head and Neck Neoplasms -- pathology KW - Head and Neck Neoplasms -- mortality KW - Carcinoma, Squamous Cell -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71619291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Accelerated+superfractionated+radiotherapy+with+concomitant+boost+for+locally+advanced+head-and-neck+squamous+cell+carcinomas.&rft.au=Morris%2C+Monica+M%3BSchmidt-Ullrich%2C+Rupert+K%3BDiNardo%2C+L%3BManning%2C+Matthew+A%3BSilverman%2C+L%3BClay%2C+L%3BJohnson%2C+Christopher+R%3BAmir%2C+Cyrus&rft.aulast=Morris&rft.aufirst=Monica&rft.date=2002-03-15&rft.volume=52&rft.issue=4&rft.spage=918&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-01 N1 - Date created - 2002-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-term safety and efficacy of a once-daily niacin/lovastatin formulation for patients with dyslipidemia. AN - 71531087; 11897208 AB - Combination therapy is increasingly recommended for patients with multiple lipid disorders, especially those at high risk for coronary events. We investigated the long-term safety and effectiveness of a new drug formulation containing once-daily extended-release niacin and lovastatin. A total of 814 men and women (mean age 59 years) with dyslipidemia were enrolled in a 52-week multicenter, open-label study. We used 4 escalating doses (niacin/lovastatin in milligrams): 500/10 for the first month, 1,000/20 for the second, 1,500/30 for the third, and 2,000/40 for the fourth month through week 52. Dose-dependent effects were observed for all major lipid parameters. At week 16, mean low-density lipoprotein (LDL) cholesterol and triglycerides were reduced by 47% and 41%, respectively; mean high-density lipoprotein (HDL) cholesterol was increased by 30% (all p 3 times the upper limit of normal was 0.5%. Once-daily niacin/lovastatin exhibits substantial effects on multiple lipid risk factors and represents a significant new treatment option in the management of dyslipidemia. JF - The American journal of cardiology AU - Kashyap, Moti L AU - McGovern, Mark E AU - Berra, Kathleen AU - Guyton, John R AU - Kwiterovich, Peter O AU - Harper, Wayne L AU - Toth, Phillip D AU - Favrot, Laurence K AU - Kerzner, Boris AU - Nash, Stephen D AU - Bays, Harold E AU - Simmons, Phillip D AD - Veterans Affairs Healthcare System, Long Beach, California 90822, USA. moti.kashyap@med.va.gov Y1 - 2002/03/15/ PY - 2002 DA - 2002 Mar 15 SP - 672 EP - 678 VL - 89 IS - 6 SN - 0002-9149, 0002-9149 KW - Cholesterol, HDL KW - 0 KW - Cholesterol, LDL KW - Delayed-Action Preparations KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Lipoprotein(a) KW - Niacin KW - 2679MF687A KW - C-Reactive Protein KW - 9007-41-4 KW - Lovastatin KW - 9LHU78OQFD KW - Abridged Index Medicus KW - Index Medicus KW - C-Reactive Protein -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Aged KW - Cholesterol, LDL -- drug effects KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Cholesterol, HDL -- drug effects KW - Female KW - Lipoprotein(a) -- drug effects KW - Male KW - Survival Analysis KW - Lovastatin -- adverse effects KW - Niacin -- adverse effects KW - Hyperlipidemias -- mortality KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- administration & dosage KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- adverse effects KW - Lovastatin -- administration & dosage KW - Hyperlipidemias -- drug therapy KW - Hyperlipidemias -- complications KW - Niacin -- administration & dosage KW - Hyperlipidemias -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71531087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+cardiology&rft.atitle=Long-term+safety+and+efficacy+of+a+once-daily+niacin%2Flovastatin+formulation+for+patients+with+dyslipidemia.&rft.au=Kashyap%2C+Moti+L%3BMcGovern%2C+Mark+E%3BBerra%2C+Kathleen%3BGuyton%2C+John+R%3BKwiterovich%2C+Peter+O%3BHarper%2C+Wayne+L%3BToth%2C+Phillip+D%3BFavrot%2C+Laurence+K%3BKerzner%2C+Boris%3BNash%2C+Stephen+D%3BBays%2C+Harold+E%3BSimmons%2C+Phillip+D&rft.aulast=Kashyap&rft.aufirst=Moti&rft.date=2002-03-15&rft.volume=89&rft.issue=6&rft.spage=672&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+cardiology&rft.issn=00029149&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-04-02 N1 - Date created - 2002-03-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antibiotic-Resistant Gram-Negative Organisms in Pediatric Chronic-Care Facilities AN - 18465476; 5433981 AB - This study was designed to define the prevalence of colonization with antibiotic-resistant gram-negative bacilli among children residing in long-term care facilities and to determine the frequency of cross-colonization with these organisms. Pharyngeal and rectal specimens were obtained from subjects residing in 2 pediatric extended-care facilities and were processed to identify gram-negative organisms resistant to ceftazidime, gentamicin, meropenem, and piperacillin-tazobactam. Horizontal transmission was assessed by analyzing all resistant isolates by pulsed-field gel electrophoresis. Forty percent of subjects were colonized with greater than or equal to 1 resistant bacillus; >60% of organisms were resistant to greater than or equal to 2 of the antibiotics tested. Colonization was disproportionate among residents with a tracheostomy or other prosthesis. More than 65% of colonized subjects shared greater than or equal to 1 organism with another resident, with cross-colonization occurring among both enteric and nonenteric species. Children residing in chronic-care facilities represent a large reservoir for resistant bacilli. Such colonization may be amenable to simple barrier infection-control procedures. JF - Clinical Infectious Diseases AU - Lidsky, K AU - Hoyen, C AU - Salvator, A AU - Rice, L B AU - Toltzis, P AD - Department of Pediatrics, Rainbow Babies and Children's Hospital of the University Hospitals of Cleveland, and Department of Medicine, Louis Stokes Cleveland Veterans Administration Hospital, Cleveland, Ohio, USA Y1 - 2002/03/15/ PY - 2002 DA - 2002 Mar 15 SP - 760 EP - 766 VL - 34 IS - 6 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18465476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Antibiotic-Resistant+Gram-Negative+Organisms+in+Pediatric+Chronic-Care+Facilities&rft.au=Lidsky%2C+K%3BHoyen%2C+C%3BSalvator%2C+A%3BRice%2C+L+B%3BToltzis%2C+P&rft.aulast=Lidsky&rft.aufirst=K&rft.date=2002-03-15&rft.volume=34&rft.issue=6&rft.spage=760&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Expression of the proto-oncogene eIF4E in inflammation of the oral cavity. AN - 85375723; pmid-11956537 AB - eIF4E (4E) is elevated in 100% of head and neck squamous cell carcinoma (HNSCC) and in premalignant lesions of the larynx. However, it is not elevated in normal mucosa. In this study, we hypothesize that 4E is not significantly elevated in inflammation unlike its expression in premalignant lesions of the oral cavity.Biopsies from the oral cavity were divided into 5 groups: (1) normal mucosa, (2) chronic inflammation, (3) mild dysplasia from leukoplakic lesions, (4) mild dysplasia in surgical margins of patients with HNSCC, and (5) HNSCC. Immunohistochemical qualitative analysis was then performed.None of the 15 specimens in group 1 and 100% of the 15 specimens in group 5 expressed 4E. Of the 29 specimens in group 2 only 4/29 (13%) overexpressed 4E compared with 10/31 (32%) in group 3 and 9/21 (42%) in group 4. There was a significant difference between groups 2 and 3 and groups 2 and 4 (P < 0.0001 and P < 0.003 respectively) but no significant difference between groups 1 and 2 (P = 0.13) and between groups 3 and 4 (P = 0.30).4E is not significantly elevated in inflammation of the oral cavity thus fulfilling one of the criteria that biomarkers require to be useful in a clinical setting. JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery AU - Chandy, Binoy AU - Abreo, Fleurette AU - Nassar, Raja AU - Stucker, Fred J AU - Nathan, Cherie-Ann AD - Department of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Science Center and Veterans Administration Shreveport, 71130, USA. Y1 - 2002/03// PY - 2002 DA - Mar 2002 SP - 290 EP - 295 VL - 126 IS - 3 SN - 0194-5998, 0194-5998 KW - Index Medicus KW - National Library of Medicine KW - Biopsy KW - *Carcinoma, Squamous Cell: genetics KW - Eukaryotic Initiation Factor-4E KW - Humans KW - *Leukoplakia, Oral: genetics KW - Leukoplakia, Oral: pathology KW - Male KW - Middle Aged KW - Mouth Mucosa KW - *Mouth Neoplasms: genetics KW - *Peptide Initiation Factors: analysis KW - Peptide Initiation Factors: genetics KW - *Stomatitis: genetics KW - *Tumor Markers, Biological: analysis KW - Tumor Markers, Biological: genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85375723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=Expression+of+the+proto-oncogene+eIF4E+in+inflammation+of+the+oral+cavity.&rft.au=Chandy%2C+Binoy%3BAbreo%2C+Fleurette%3BNassar%2C+Raja%3BStucker%2C+Fred+J%3BNathan%2C+Cherie-Ann&rft.aulast=Chandy&rft.aufirst=Binoy&rft.date=2002-03-01&rft.volume=126&rft.issue=3&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Cognition and aphasia: a discussion and a study. AN - 85370744; pmid-12036150 AB - The relation between other aspects of cognition and language status of individuals with aphasia is not well-established, although there is some evidence that integrity of non-linguistic skills of attention, memory, executive function and visuospatial skills can not be predicted on the basis of aphasia severity. At the same time, there is a growing realization among rehabilitation specialists, based on clinical experience and preliminary studies, that all domains of cognition are important to aphasia therapy outcomes. This paper describes a new study of the relation between linguistic and nonlinguistic skill in a group of individuals with aphasia. No significant relationship was found between linguistic and nonlinguistic skills, and between nonlinguistic skills and age, education or time post onset. Instead, individual profiles of strengths and weaknesses were found. The implications of these findings for management of aphasia patients is discussed. Learning outcomes: Readers of this papers will be able to: list five primary domains of cognition and relate each to an aspect of aphasia therapy; describe at least three studies that examined the relation between cognition and aphasia; describe four nonlinguistic tasks of cognition that can be used with a wide range of aphasia patients. JF - Journal of communication disorders AU - Helm-Estabrooks, Nancy AD - Harold Goodglass Aphasia Research Center, Boston Veterans Administration Medical Center, Boston University School of Medicine, MA 02130, USA. nancyhe@bu.edu Y1 - 2002/03// PY - 2002 DA - Mar 2002 SP - 171 EP - 186 VL - 35 IS - 2 SN - 0021-9924, 0021-9924 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - *Aphasia: complications KW - Aphasia: diagnosis KW - Cognition Disorders: diagnosis KW - *Cognition Disorders: etiology KW - Female KW - Humans KW - Male KW - Middle Aged KW - Neuropsychological Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85370744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+communication+disorders&rft.atitle=Cognition+and+aphasia%3A+a+discussion+and+a+study.&rft.au=Helm-Estabrooks%2C+Nancy&rft.aulast=Helm-Estabrooks&rft.aufirst=Nancy&rft.date=2002-03-01&rft.volume=35&rft.issue=2&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Journal+of+communication+disorders&rft.issn=00219924&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - New semantic and serial clustering indices for the California Verbal Learning Test-Second Edition: background, rationale, and formulae. AN - 85369952; pmid-11939700 AB - The original California Verbal Learning Test (CVLT) employed a semantic clustering index that used the words recalled during a given trial as the baseline for calculating expected values of chance clustering (recall-based expectancy). Although commonly used in cognitive psychology, clustering indices that use recall-based calculations of expectancy are implied by the assumption that organizational processes do not occur until after words are retrieved from memory. This assumption contradicts the generally held assumptions among neuropsychologists that (1) organization is an antecedent to recall, and (2) increases in the use of organizational strategies will result in better recall performance. After reviewing a brief history of clustering metrics, we used Monte Carlo simulations, informative examples, and patient data to examine clustering indices that use the word list as a baseline for calculating expectancy and propose these list-based expectancy measures as a refinement of the clustering indices used on the original CVLT. These indices are used on the recently published CVLT-II. JF - Journal of the International Neuropsychological Society : JINS AU - Stricker, John L AU - Brown, Gregory G AU - Wixted, John AU - Baldo, Juliana V AU - Delis, Dean C AD - Psychology Service, Veterans Administration San Diego Healthcare System, CA 92161, USA. Y1 - 2002/03// PY - 2002 DA - Mar 2002 SP - 425 EP - 435 VL - 8 IS - 3 SN - 1355-6177, 1355-6177 KW - Index Medicus KW - National Library of Medicine KW - Cluster Analysis KW - Humans KW - *Mental Recall KW - Monte Carlo Method KW - *Neuropsychological Tests: statistics & numerical data KW - Psychometrics KW - Reproducibility of Results KW - *Semantics KW - Serial Learning KW - *Verbal Learning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85369952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.atitle=New+semantic+and+serial+clustering+indices+for+the+California+Verbal+Learning+Test-Second+Edition%3A+background%2C+rationale%2C+and+formulae.&rft.au=Stricker%2C+John+L%3BBrown%2C+Gregory+G%3BWixted%2C+John%3BBaldo%2C+Juliana+V%3BDelis%2C+Dean+C&rft.aulast=Stricker&rft.aufirst=John&rft.date=2002-03-01&rft.volume=8&rft.issue=3&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Neuropsychological+Society+%3A+JINS&rft.issn=13556177&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Malignant mesothelioma and occupational exposure to asbestos: a clinicopathological correlation of 1445 cases. AN - 71759223; 12036093 AB - Asbestos exposure is indisputably associated with development of mesothelioma. However, relatively few studies have evaluated the type of occupational exposure in correlation with asbestos fiber content and type. This study reports findings in 1445 cases of mesothelioma with known exposure history; 268 of these also had fiber burden analysis. The 1445 cases of mesothelioma were subclassified into 23 predominant occupational or exposure categories. Asbestos body counts per gram of wet lung tissue were determined by light microscopy. Asbestos fiber content and type were determined by scanning electron microscopy and energy dispersive x-ray analysis. Results were compared with a control group of 19 lung tissue samples. Ninety-four percent of the cases occurred among 19 exposure categories. Median asbestos body counts and levels of commercial and noncommercial amphibole fibers showed elevated levels for each of these 19 categories. Chrysotile fibers were detectable in 36 of 268 cases. All but 2 of these also had above-background levels of commercial amphiboles. When compared to commercial amphiboles, the median values for noncommercial amphibole fibers were higher in 4 of the 19 exposure groups. Most mesotheliomas in the United States fall into a limited number of exposure categories. Although a predominant occupation was ascertained for each of these cases, there was a substantial overlap in exposure types. All but 1 of the occupational categories analyzed had above-background levels of commercial amphiboles. Commercial amphiboles are responsible for most of the mesothelioma cases observed in the United States. JF - Ultrastructural pathology AU - Roggli, Victor L AU - Sharma, Anupama AU - Butnor, Kelly J AU - Sporn, Thomas AU - Vollmer, Robin T AD - Department of Pathology, Durham Veterans Administration and Duke University Medical Center, North Carolina 27710, USA. PY - 2002 SP - 55 EP - 65 VL - 26 IS - 2 SN - 0191-3123, 0191-3123 KW - Mineral Fibers KW - 0 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Disease-Free Survival KW - Mineral Fibers -- analysis KW - Body Burden KW - Humans KW - Aged KW - Lung -- metabolism KW - Survival Rate KW - Aged, 80 and over KW - Mineral Fibers -- classification KW - Adult KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Asbestos -- analysis KW - Mesothelioma -- secondary KW - Pleural Neoplasms -- mortality KW - Occupational Exposure -- classification KW - Mesothelioma -- etiology KW - Pleural Neoplasms -- pathology KW - Peritoneal Neoplasms -- pathology KW - Peritoneal Neoplasms -- mortality KW - Peritoneal Neoplasms -- etiology KW - Asbestos -- classification KW - Mesothelioma -- mortality KW - Asbestos -- adverse effects KW - Occupational Exposure -- adverse effects KW - Pleural Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71759223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrastructural+pathology&rft.atitle=Malignant+mesothelioma+and+occupational+exposure+to+asbestos%3A+a+clinicopathological+correlation+of+1445+cases.&rft.au=Roggli%2C+Victor+L%3BSharma%2C+Anupama%3BButnor%2C+Kelly+J%3BSporn%2C+Thomas%3BVollmer%2C+Robin+T&rft.aulast=Roggli&rft.aufirst=Victor&rft.date=2002-03-01&rft.volume=26&rft.issue=2&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Ultrastructural+pathology&rft.issn=01913123&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-11-07 N1 - Date created - 2002-05-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Suicide prevalence in chemical dependency programs: preliminary data from a national sample, and an examination of risk factors. AN - 71577468; 11932135 AB - Completed suicides over a one year period of time were reported from a nationwide survey of Department of Veteran Affairs medical centers. Of a total of 248 completed suicides, 11 occurred in outpatient substance abuse programs, and an additional 5 occurred among patients receiving combined outpatient substance abuse and psychiatric treatment. There were no inpatient suicides. During this time, there were 7 suicide attempts on inpatient units and 37 suicide attempts in outpatient chemical dependency treatment. The majority of suicides were committed by males who had a primary alcohol addiction (63%). Thirty-eight percent of the sample had a comorbid mood disorder and 38% had a comorbid personality disorder. Risk factors relating to the potential for suicide in chemical dependency programs are discussed. JF - Journal of substance abuse treatment AU - Kausch, Otto AU - McCormick, Richard A AD - Case Western Reserve University School of Medicine, Cleveland, OH, USA. otto.kausch@med.va.gov Y1 - 2002/03// PY - 2002 DA - March 2002 SP - 97 EP - 102 VL - 22 IS - 2 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - Suicide, Attempted -- statistics & numerical data KW - Risk Factors KW - National Health Programs -- statistics & numerical data KW - Humans KW - Adult KW - Veterans -- psychology KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Prevalence KW - Hospitals, Veterans KW - Substance-Related Disorders -- therapy KW - Substance Abuse Treatment Centers -- statistics & numerical data KW - Substance-Related Disorders -- psychology KW - Suicide -- statistics & numerical data KW - Suicide -- prevention & control KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71577468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Suicide+prevalence+in+chemical+dependency+programs%3A+preliminary+data+from+a+national+sample%2C+and+an+examination+of+risk+factors.&rft.au=Kausch%2C+Otto%3BMcCormick%2C+Richard+A&rft.aulast=Kausch&rft.aufirst=Otto&rft.date=2002-03-01&rft.volume=22&rft.issue=2&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-08-14 N1 - Date created - 2002-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of opioid medications for chronic noncancer pain syndromes in primary care. AN - 71566690; 11929502 AB - To define the spectrum of chronic noncancer pain treated with opioid medications in 2 primary care settings, and the prevalence of psychiatric comorbidity in this patient population. We also sought to determine the proportion of patients who manifested prescription opioid abuse behaviors and the factors associated with these behaviors. A retrospective cohort study. A VA primary care clinic and an urban hospital-based primary care center (PCC) located in the northeastern United States. A random sample of VA patients ( n=50) and all PCC patients ( n=48) with chronic noncancer pain who received 6 or more months of opioid prescriptions during a 1-year period (April 1, 1997 through March 31, 1998) and were not on methadone maintenance. Information regarding patients' type of chronic pain disorder, demographic, medical, and psychiatric status, and the presence of prescription opioid abuse behaviors was obtained by medical record review. Low back pain was the most common disorder accounting for 44% and 25% of all chronic pain diagnoses in the VA and PCC samples, respectively, followed by injury-related (10% and 13%), diabetic neuropathy (8% and 10%), degenerative joint disease (16% and 13%), spinal stenosis (10% and 4%), headache (4% and 13%) and other chronic pain disorders (8% and 22%). The median duration of pain was 10 years (range 3 to 50 years) in the VA and 13 years in the PCC sample (range 1 to 49 years). Among VA and PCC patients, the lifetime prevalence rates of psychiatric comorbidities were: depressive disorder (44% and 54%), anxiety disorder (20% and 21%), alcohol abuse/dependence (46% and 31%), and narcotic abuse/dependence (18% and 38%). Prescription opioid abusive behaviors were recorded for 24% of VA and 31% of PCC patients. A lifetime history of a substance use disorder (adjusted odds ratio [OR], 3.8; 95% confidence interval [CI], 1.4 to 10.8) and age (adjusted OR, 0.94; 95% CI, 0.89 to 0.99) were independent predictors of prescription opioid abuse behavior. A broad spectrum of chronic noncancer pain disorders are treated with opioid medications in primary care settings. The lifetime prevalence of psychiatric comorbidity was substantial in our study population. A significant minority of patients manifested prescription opioid abusive behaviors, and a lifetime history of a substance use disorder and decreasing age were associated with prescription opioid abuse behavior. Prospective studies are needed to determine the potential benefits as well as risks associated with opioid use for chronic noncancer pain in primary care. JF - Journal of general internal medicine AU - Reid, M Carrington AU - Engles-Horton, Laura L AU - Weber, MaryAnn B AU - Kerns, Robert D AU - Rogers, Elizabeth L AU - O'Connor, Patrick G AD - Clinical Epidemiology Unit, VA Connecticut Healthcare System, West Haven Conn. 06516, USA. reid.manney@west-haven.va.gov Y1 - 2002/03// PY - 2002 DA - March 2002 SP - 173 EP - 179 VL - 17 IS - 3 SN - 0884-8734, 0884-8734 KW - Analgesics, Non-Narcotic KW - 0 KW - Analgesics, Opioid KW - Index Medicus KW - United States KW - Age Factors KW - Humans KW - Retrospective Studies KW - Aged KW - Opioid-Related Disorders -- etiology KW - Comorbidity KW - Opioid-Related Disorders -- epidemiology KW - Analgesics, Non-Narcotic -- therapeutic use KW - Aged, 80 and over KW - Adult KW - Chronic Disease KW - Middle Aged KW - Female KW - Male KW - Drug Utilization -- statistics & numerical data KW - Pain -- drug therapy KW - Analgesics, Opioid -- therapeutic use KW - Primary Health Care KW - Analgesics, Opioid -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71566690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+general+internal+medicine&rft.atitle=Use+of+opioid+medications+for+chronic+noncancer+pain+syndromes+in+primary+care.&rft.au=Reid%2C+M+Carrington%3BEngles-Horton%2C+Laura+L%3BWeber%2C+MaryAnn+B%3BKerns%2C+Robert+D%3BRogers%2C+Elizabeth+L%3BO%27Connor%2C+Patrick+G&rft.aulast=Reid&rft.aufirst=M&rft.date=2002-03-01&rft.volume=17&rft.issue=3&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Journal+of+general+internal+medicine&rft.issn=08848734&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-08-02 N1 - Date created - 2002-04-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pain. 1999 Mar;80(1-2):1-13 [10204712] J Pain Symptom Manage. 1998 Dec;16(6):355-63 [9879160] Med Clin North Am. 1999 May;83(3):787-808, vii-viii [10386125] J Pain Symptom Manage. 1999 Jul;18(1):38-48 [10439571] Arch Intern Med. 1999 Aug 9-23;159(15):1681-9 [10448769] Med Clin North Am. 1999 May;83(3):555-83, v [10386115] NIDA Res Monogr. 1981 May;36:66-75 [6791027] Am J Psychiatry. 1985 Oct;142(10):1156-60 [4037126] Pain. 1986 May;25(2):171-86 [2873550] Pain. 1986 Aug;26(2):181-97 [3763232] J Chronic Dis. 1987;40(5):373-83 [3558716] Pain. 1989 Mar;36(3):363-6 [2710565] Psychosom Med. 1991 Jan-Feb;53(1):61-79 [2011651] Pain. 1991 May;45(2):111-21 [1831555] J Pain Symptom Manage. 1992 Feb;7(2):69-77 [1573287] Pain. 1992 May;49(2):205-19 [1535121] Gen Hosp Psychiatry. 1992 Jul;14(4):237-47 [1505745] Arch Gen Psychiatry. 1994 Sep;51(9):740-50 [8080351] J Pain Symptom Manage. 1993 Jul;8(5):289-96 [7525745] Pain. 1994 Nov;59(2):201-8 [7892017] J Gen Intern Med. 1995 Jan;10(1):7-12 [7699487] Med J Aust. 1995 Aug 21;163(4):181-2 [7651250] BMJ. 1995 Oct 21;311(7012):1047-52 [7580659] JAMA. 1996 Jul 24-31;276(4):313-8 [8656544] Pain. 1996 May-Jun;65(2-3):197-204 [8826507] Psychosomatics. 1996 May-Jun;37(3):223-35 [8849499] J Pain Symptom Manage. 1996 Apr;11(4):218-30 [8869457] Acta Anaesthesiol Scand. 1997 Jan;41(1 Pt 2):187-90 [9061105] Clin J Pain. 1997 Mar;13(1):6-8 [9084947] Spine (Phila Pa 1976). 1996 Dec 15;21(24):2874-8; discussion 2878-9 [9112711] Clin J Pain. 1997 Jun;13(2):150-5 [9186022] Med J Aust. 1997 Jul 7;167(1):26-9 [9236756] J Rehabil Res Dev. 1997 Oct;34(4):383-93 [9323642] Pain. 1997 Dec;73(3):393-400 [9469530] JAMA. 1998 Jul 8;280(2):147-51 [9669787] Spine (Phila Pa 1976). 1998 Jul 1;23(13):1457-63 [9670397] Am J Med. 1998 Jul 27;105(1B):45S-52S [9715834] Comment In: J Gen Intern Med. 2002 Mar;17(3):238-40 [11929512] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neurotoxic syndrome associated with risperidone and fluvoxamine. AN - 71523248; 11895057 AB - To report a case of a neurotoxic syndrome in a patient undergoing concomitant treatment with risperidone and fluvoxamine. A 24-year-old African American woman hospitalized for psychosis was unresponsive to risperidone. Because of obsessive symptoms, low doses of fluvoxamine were added to her treatment regimen. Within 2 days, she developed confusion, diaphoresis, diarrhea, hyperreflexia, and myoclonus, which then progressed to rigidity, fever, and unresponsiveness, requiring endotracheal intubation. Symptoms resolved over 10 days with discontinuation of medication, hydration, and bromocriptine 5 mg 3 times daily. Ultimately, she was treated with olanzapine and fluvoxamine without adverse effects. This represents the first reported case of a neurotoxic syndrome secondary to treatment with risperidone and fluvoxamine. Differential diagnosis between neuroleptic malignant syndrome (NMS) and serotonin syndrome (SS) could not be accurately determined because of the overlap of signs and symptoms of both syndromes. NMS and SS may represent different aspects of a more generalized neurotoxic syndrome. This could be an important consideration in formulating treatment for neurotoxic syndromes. Clinicians should be aware of potentially serious adverse reactions that may occur during concomitant treatment with antipsychotics and selective serotonin-reuptake inhibitors. JF - The Annals of pharmacotherapy AU - Reeves, Roy R AU - Mack, James E AU - Beddingfield, John J AD - GV (Sonny) Montgomery Veterans Administration Medical Center, Department of Psychiatry, Jackson, MS 39216-5116, USA. roy.reeves2@med.va.gov Y1 - 2002/03// PY - 2002 DA - March 2002 SP - 440 EP - 443 VL - 36 IS - 3 SN - 1060-0280, 1060-0280 KW - Antipsychotic Agents KW - 0 KW - Serotonin Uptake Inhibitors KW - Risperidone KW - L6UH7ZF8HC KW - Fluvoxamine KW - O4L1XPO44W KW - Index Medicus KW - Neurotoxicity Syndromes -- diagnosis KW - Neuroleptic Malignant Syndrome -- etiology KW - Drug Interactions KW - Neuroleptic Malignant Syndrome -- diagnosis KW - Humans KW - Neurotoxicity Syndromes -- etiology KW - Adult KW - Neurotoxicity Syndromes -- physiopathology KW - Female KW - Fluvoxamine -- adverse effects KW - Risperidone -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Serotonin Uptake Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71523248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Neurotoxic+syndrome+associated+with+risperidone+and+fluvoxamine.&rft.au=Reeves%2C+Roy+R%3BMack%2C+James+E%3BBeddingfield%2C+John+J&rft.aulast=Reeves&rft.aufirst=Roy&rft.date=2002-03-01&rft.volume=36&rft.issue=3&rft.spage=440&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-08-22 N1 - Date created - 2002-03-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Pharmacother. 2002 Jul-Aug;36(7-8):1293; author reply 1294 [12086569] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. AN - 71498703; 11880489 AB - There is substantial evidence that bioenergetic defects and excitotoxicity may play a role in the pathogenesis of Huntington's disease (HD). Potential therapeutic strategies for neurodegenerative diseases in which there is reduced energy metabolism and NMDA-mediated excitotoxicity are the administration of the mitochondrial cofactor coenzyme Q10 and the NMDA antagonist remacemide. We found that oral administration of either coenzyme Q10 or remacemide significantly extended survival and delayed the development of motor deficits, weight loss, cerebral atrophy, and neuronal intranuclear inclusions in the R6/2 transgenic mouse model of HD. The combined treatment, using coenzyme Q10 and remacemide together, was more efficacious than either compound alone, resulting in an approximately 32 and 17% increase in survival in the R6/2 and N171-82Q mice, respectively. Magnetic resonance imaging showed that combined treatment significantly attenuated ventricular enlargement in vivo. These studies further implicate defective energy metabolism and excitotoxicity in the R6/2 and N171-82Q transgenic mouse models of HD and are of interest in comparison with the outcome of a recent clinical trial examining coenzyme Q10 and remacemide in HD patients. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Ferrante, Robert J AU - Andreassen, Ole A AU - Dedeoglu, Alpaslan AU - Ferrante, Kimberly L AU - Jenkins, Bruce G AU - Hersch, Steven M AU - Beal, M Flint AD - Geriatric Research Education and Clinical Center, Bedford Veterans Administration Medical Center, Bedford, Massachusetts 01730, USA. rjferr@bu.edu Y1 - 2002/03/01/ PY - 2002 DA - 2002 Mar 01 SP - 1592 EP - 1599 VL - 22 IS - 5 KW - Acetamides KW - 0 KW - Coenzymes KW - HTT protein, human KW - Hdh protein, mouse KW - Huntingtin Protein KW - Nerve Tissue Proteins KW - Nuclear Proteins KW - Ubiquinone KW - 1339-63-5 KW - remacemide KW - EH6763C1IC KW - coenzyme Q10 KW - EJ27X76M46 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Administration, Oral KW - Animals KW - Nuclear Proteins -- genetics KW - Humans KW - Brain -- drug effects KW - Cerebral Ventricles -- pathology KW - Disease Progression KW - Disease Models, Animal KW - Mice KW - Nerve Tissue Proteins -- genetics KW - Mice, Transgenic KW - Cerebral Ventricles -- drug effects KW - Behavior, Animal -- drug effects KW - Survival Rate KW - Brain -- pathology KW - Body Weight -- drug effects KW - Treatment Outcome KW - Motor Activity -- drug effects KW - Drug Synergism KW - Drug Evaluation, Preclinical KW - Male KW - Female KW - Organ Size -- drug effects KW - Ubiquinone -- therapeutic use KW - Huntington Disease -- drug therapy KW - Huntington Disease -- pathology KW - Acetamides -- therapeutic use KW - Ubiquinone -- analogs & derivatives KW - Huntington Disease -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71498703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Therapeutic+effects+of+coenzyme+Q10+and+remacemide+in+transgenic+mouse+models+of+Huntington%27s+disease.&rft.au=Ferrante%2C+Robert+J%3BAndreassen%2C+Ole+A%3BDedeoglu%2C+Alpaslan%3BFerrante%2C+Kimberly+L%3BJenkins%2C+Bruce+G%3BHersch%2C+Steven+M%3BBeal%2C+M+Flint&rft.aulast=Ferrante&rft.aufirst=Robert&rft.date=2002-03-01&rft.volume=22&rft.issue=5&rft.spage=1592&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-22 N1 - Date created - 2002-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The gastrin receptor promotes pancreatic growth in transgenic mice. AN - 71467107; 11854616 AB - We demonstrated previously, in two different rodent models of pancreatic cancer, that the gastrin receptor is present on malignant pancreatic tumors in spite of the fact that the normal adult rat and mouse pancreas does not express gastrin receptors. To determine whether gastrin receptors mediate pancreatic growth or promote carcinogenesis or both, we created a transgenic mouse that constitutively expresses gastrin receptors in the exocrine pancreas. The transgene construct contained the full-length rat gastrin receptor cDNA sequence under the control of the rat elastase promoter. Receptor presence and function on exocrine pancreatic tissue of transgenic but not control mice were confirmed by (125)I-gastrin-I binding studies and by gastrin stimulation of intracellular calcium release. Eighteen-month-old transgenic animals had larger pancreas-to-body weight ratios than their nontransgenic littermate controls (p < 0.001 for females; p < 0.01 for males); however, histopathologic examination revealed no neoplasms or other abnormalities. In both female and male transgenic mice, the expression of the gastrin receptor in the exocrine pancreas is associated with a significant increase in pancreas weight, but it does not appear to promote the development of spontaneous pancreatic tumors. JF - Pancreas AU - Yen, Tina W F AU - Sandgren, Eric P AU - Liggitt, H Denny AU - Palmiter, Richard D AU - Zhou, Weigong AU - Hinds, Thomas R AU - Grippo, Paul J AU - McDonald, Jerome M AU - Robinson, Linda M AU - Bell, Richard H AD - Surgical Service, Veterans Administration Puget Sound Health Care System, University of Washington School of Medicine, Seattle, Washington, U.S.A. Y1 - 2002/03// PY - 2002 DA - March 2002 SP - 121 EP - 129 VL - 24 IS - 2 SN - 0885-3177, 0885-3177 KW - Gastrins KW - 0 KW - Iodine Radioisotopes KW - Receptors, Cholecystokinin KW - gastrin I KW - 9045-90-3 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Gastrins -- metabolism KW - Gene Expression KW - Mice KW - Mice, Transgenic KW - Rats KW - Phenotype KW - Calcium -- metabolism KW - Adenocarcinoma -- physiopathology KW - Pancreatic Neoplasms -- physiopathology KW - Gastrins -- pharmacology KW - Female KW - Male KW - Receptors, Cholecystokinin -- genetics KW - Receptors, Cholecystokinin -- metabolism KW - Pancreas -- growth & development KW - Pancreas -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71467107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pancreas&rft.atitle=The+gastrin+receptor+promotes+pancreatic+growth+in+transgenic+mice.&rft.au=Yen%2C+Tina+W+F%3BSandgren%2C+Eric+P%3BLiggitt%2C+H+Denny%3BPalmiter%2C+Richard+D%3BZhou%2C+Weigong%3BHinds%2C+Thomas+R%3BGrippo%2C+Paul+J%3BMcDonald%2C+Jerome+M%3BRobinson%2C+Linda+M%3BBell%2C+Richard+H&rft.aulast=Yen&rft.aufirst=Tina+W&rft.date=2002-03-01&rft.volume=24&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Pancreas&rft.issn=08853177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-11 N1 - Date created - 2002-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Violence among individuals in substance abuse treatment: the role of alcohol and cocaine consumption. AN - 71449192; 11850133 AB - This study examined factors associated with expressed violence in the 90 days prior to substance abuse (SA) treatment among 125 men and 125 women recently enrolled in treatment. Approximately 85% of the sample reported a significant conflict situation, and over 32% reported an incident of physical violence. Both general alcohol and cocaine use patterns (on days not involving significant interpersonal conflict), as well as alcohol and cocaine use on the day of the violent incident, were associated with violence severity. Regression analyses revealed that race, education, age, and both general drinking and cocaine use patterns were associated with violence severity for the most severe violent incident reported. Similarly, regression analyses focusing on alcohol and cocaine use on the day of the most severe incident revealed that higher drinking levels, younger age, minority status, and the interaction of alcohol and cocaine use were associated with violence severity. The results provide important information regarding factors associated with expression of violence among men and women in SA treatment, and have implications regarding the assessment of violence risk factors. Further, the findings suggest that screening and intervention approaches for violence-related problems should be routine in SA treatment, and appear to be especially indicated for patients reporting alcohol consumption, and co-occurring alcohol and cocaine consumption. JF - Drug and alcohol dependence AU - Chermack, Stephen T AU - Blow, Frederic C AD - John D. Dingell VA Medical Center, 4646 John R. Street, Detroit, MI 48201, USA. stephen.chermack@med.va.gov Y1 - 2002/03/01/ PY - 2002 DA - 2002 Mar 01 SP - 29 EP - 37 VL - 66 IS - 1 SN - 0376-8716, 0376-8716 KW - Index Medicus KW - Regression Analysis KW - Analysis of Variance KW - Humans KW - Aged KW - Substance-Related Disorders -- psychology KW - Substance-Related Disorders -- therapy KW - Substance Abuse Treatment Centers -- statistics & numerical data KW - Risk Factors KW - Adult KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Substance-Related Disorders -- epidemiology KW - Alcohol Drinking -- therapy KW - Violence -- statistics & numerical data KW - Cocaine-Related Disorders -- psychology KW - Alcohol Drinking -- psychology KW - Cocaine-Related Disorders -- therapy KW - Cocaine-Related Disorders -- epidemiology KW - Alcohol Drinking -- epidemiology KW - Violence -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71449192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Violence+among+individuals+in+substance+abuse+treatment%3A+the+role+of+alcohol+and+cocaine+consumption.&rft.au=Chermack%2C+Stephen+T%3BBlow%2C+Frederic+C&rft.aulast=Chermack&rft.aufirst=Stephen&rft.date=2002-03-01&rft.volume=66&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-05-16 N1 - Date created - 2002-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of carotid and aortic chemoreceptor denervation in newborn piglets. AN - 71429653; 11842019 AB - The objective of the present study was to test the hypothesis that in neonatal piglets there would be no hypoventilation after sham denervation or aortic denervation (AOD) alone, but there would be transient hypoventilation after carotid body denervation (CBD) and the hypoventilation would be greatest after combined carotid and aortic denervation (CBD+AOD). There was a significant (P < 0.05) hypoventilation in CBD and CBD+AOD piglets denervated at 5, 15, and 25 days of age. The hypoventilation in CBD+AOD piglets denervated at 5 days of age was greater (P < 0.05) than that of all other groups. Conversely, sham-denervated and AOD piglets did not hypoventilate after denervation. Injections of sodium cyanide showed that aortic chemoreceptors were a site of recovery of peripheral chemosensitivity after CBD. This aortic sodium cyanide response was abolished by prior injection of a serotonin 5a receptor blocker. Residual peripheral chemosensitivity after CBD+AOD was localized to the left ventricle. We conclude that 1) aortic chemoreceptors contribute to eupneic breathing in piglets that were carotid denervated at 5 days of age and 2) there are multiple sites of residual peripheral chemosensitivity after CBD. JF - Journal of applied physiology (Bethesda, Md. : 1985) AU - Serra, A AU - Brozoski, D AU - Hodges, M AU - Roethle, S AU - Franciosi, R AU - Forster, H V AD - Department of Physiology, Medical College of Wisconsin and Zablocki Veterans Administration Medical Center, Milwaukee, Wisconsin 53226-0509, USA. Y1 - 2002/03// PY - 2002 DA - March 2002 SP - 893 EP - 900 VL - 92 IS - 3 SN - 8750-7587, 8750-7587 KW - Sodium Cyanide KW - O5DDB9Z95G KW - Index Medicus KW - Swine KW - Sodium Cyanide -- pharmacology KW - Mortality KW - Jugular Veins KW - Animals KW - Reference Values KW - Blood Pressure -- physiology KW - Injections, Intravenous KW - Injections, Intra-Arterial KW - Baroreflex -- physiology KW - Denervation KW - Sodium Cyanide -- administration & dosage KW - Hypoxia -- physiopathology KW - Chemoreceptor Cells -- physiology KW - Aorta -- innervation KW - Respiratory Physiological Phenomena KW - Animals, Newborn -- growth & development KW - Carotid Arteries -- innervation KW - Animals, Newborn -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71429653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.atitle=Effects+of+carotid+and+aortic+chemoreceptor+denervation+in+newborn+piglets.&rft.au=Serra%2C+A%3BBrozoski%2C+D%3BHodges%2C+M%3BRoethle%2C+S%3BFranciosi%2C+R%3BForster%2C+H+V&rft.aulast=Serra&rft.aufirst=A&rft.date=2002-03-01&rft.volume=92&rft.issue=3&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+physiology+%28Bethesda%2C+Md.+%3A+1985%29&rft.issn=87507587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-05-07 N1 - Date created - 2002-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Combined chemotherapy and radiation therapy for head and neck malignancies: quality of life issues. AN - 71549270; 11920484 AB - The standard of care for locally advanced head and neck carcinoma usually has been surgery followed by radiation therapy. Patient survival using this approach has been reported to be poor. The disfiguration resulting from surgery and the long-term morbidity of postoperative radiation often results in considerable distress. Concurrent chemotherapy and radiation was introduced to improve outcome. Excellent local control and survival results often have been reported in Phase II and Phase III studies. The acute toxicity of combined chemotherapy and radiation is significant. However, organ preservation may improve quality of life. This review article summarizes the findings from published series of surgery, postoperative radiation, radiation therapy alone, and chemoradiation with regard to quality of life issues for patients with locally advanced head and neck carcinoma. A literature search was used to identify quality-of-life studies of postoperative radiation, radiation therapy alone, and chemoradiation in patients with locally advanced head and neck carcinoma. Factors affecting long-term quality-of-life issues in each treatment modality were identified, compared, and evaluated. Speech disorder, dysphagia, pain, and depression were found to be the common side effects affecting quality of life regardless of the treatment modality. Xerostomia is the major complication affecting patients undergoing radiation or chemoradiation. Acute side effects of combined chemotherapy and radiation therapy usually were found to resolve after treatment. Long-term morbidity is substantial because of xerostomia and severe dysphagia. However, preliminary studies suggest that because of organ preservation, patients may achieve a better quality of life after chemoradiation compared with the conventional use of surgery and postoperative radiation. Copyright 2002 American Cancer Society. DOI 10.1002/cncr.10257 JF - Cancer AU - Nguyen, Nam P AU - Sallah, Sabah AU - Karlsson, Ulf AU - Antoine, John E AD - Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75216, USA. NamPhong.Nguyen@med.va.gov Y1 - 2002/02/15/ PY - 2002 DA - 2002 Feb 15 SP - 1131 EP - 1141 VL - 94 IS - 4 SN - 0008-543X, 0008-543X KW - Abridged Index Medicus KW - Index Medicus KW - Speech Disorders -- etiology KW - Combined Modality Therapy KW - Humans KW - Aged KW - Morbidity KW - Xerostomia -- etiology KW - Pain -- etiology KW - Depression -- etiology KW - Adult KW - Middle Aged KW - Female KW - Male KW - Deglutition Disorders -- etiology KW - Carcinoma -- psychology KW - Carcinoma -- radiotherapy KW - Carcinoma -- drug therapy KW - Head and Neck Neoplasms -- psychology KW - Quality of Life KW - Head and Neck Neoplasms -- radiotherapy KW - Head and Neck Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71549270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Combined+chemotherapy+and+radiation+therapy+for+head+and+neck+malignancies%3A+quality+of+life+issues.&rft.au=Nguyen%2C+Nam+P%3BSallah%2C+Sabah%3BKarlsson%2C+Ulf%3BAntoine%2C+John+E&rft.aulast=Nguyen&rft.aufirst=Nam&rft.date=2002-02-15&rft.volume=94&rft.issue=4&rft.spage=1131&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-04-15 N1 - Date created - 2002-03-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Outpatient radioimmunotherapy with Bexxar. Closed, clean air reservoir minimizes personnel radiation exposure. AN - 71487536; 11877766 AB - Radioimmunotherapy (RIT) with Bexxar (tositumomab and iodine-131 tositumomab; Coulter Pharmaceutical, South San Francisco, CA) has been shown to be effective in the treatment of low-grade and transformed low-grade non-Hodgkin lymphoma (NHL). Patient-specific dosimetry with 5 mCi of iodine-131 tositumomab preceded by 450 mg of tositumomab was utilized to calculate the radionuclide dose needed to deliver 75 cGy whole-body radiation (65 cGy for platelet counts of 100,000-149,000/mm(3)). To safely infuse the approximately 95 mCi (range, 52-211mCi) of iodine-131 needed for this treatment, a shielded, closed system was developed to minimize radiation exposure for personnel administering the treatment infusions and to eliminate possible release of aerosolized iodine-131. Twenty-five patients who could be evaluated were infused with a single course of iodine-131 tositumomab therapy and achieved a 76% total response rate at 3 months (32% complete response [CR], 44% partial response [PR]); 59% total response at 6 months (40% CR, 18% PR); and 38% total response at 12 months (31% CR, 6% PR). Administration of RIT using our unique, totally closed system significantly reduced personnel exposure and potential for radioactive spills. The sum of all individuals who administered and monitored the infusions was < 120 mRem whole body exposure over 22 months, well within the ALARA (as low as reasonably achievable) Level I guideline limits. No radioiodide was detectable in the thyroid of any staff member. In NHL patients who had experienced failure with conventional therapy, RIT with iodine-131 tositumomab therapy was safe and effective. Response rates obtained were equivalent to those obtained at the university medical centers where the Phase I-III clinical trials were performed. Copyright 2002 American Cancer Society. JF - Cancer AU - Harwood, Steven J AU - Gibbons, Linda K AU - Goldner, Pamela J AU - Webster, William B AU - Carroll, Robert G AD - Department of Nuclear Medicine, Veterans Affairs Medical Center (VAMC) Bay Pines, Bay Pines, Florida 33744, USA. Steven_J@Bay-Pines.va.gov Y1 - 2002/02/15/ PY - 2002 DA - 2002 Feb 15 SP - 1358 EP - 1362 VL - 94 IS - 4 Suppl SN - 0008-543X, 0008-543X KW - Antibodies, Monoclonal KW - 0 KW - Antineoplastic Agents KW - iodine-131 anti-B1 antibody KW - K1KT5M40JC KW - Abridged Index Medicus KW - Index Medicus KW - Radioimmunotherapy KW - Radiation Protection -- methods KW - Humans KW - Adult KW - Treatment Outcome KW - Patient Selection KW - Male KW - Female KW - Ambulatory Care KW - Lymphoma, Non-Hodgkin -- drug therapy KW - Lymphoma, Non-Hodgkin -- radiotherapy KW - Antineoplastic Agents -- therapeutic use KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71487536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Outpatient+radioimmunotherapy+with+Bexxar.+Closed%2C+clean+air+reservoir+minimizes+personnel+radiation+exposure.&rft.au=Harwood%2C+Steven+J%3BGibbons%2C+Linda+K%3BGoldner%2C+Pamela+J%3BWebster%2C+William+B%3BCarroll%2C+Robert+G&rft.aulast=Harwood&rft.aufirst=Steven&rft.date=2002-02-15&rft.volume=94&rft.issue=4+Suppl&rft.spage=1358&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-08 N1 - Date created - 2002-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoter. AN - 71467897; 11829742 AB - Lipid-deprived mice increase alveolar surfactant disaturated phosphatidylcholine (DSPtdCho) synthesis compared with mice fed a standard diet by increasing expression of CTP:phosphocholine cytidylyltransferase (CCT), the rate-limiting enzyme for DSPtdCho synthesis. We previously observed that lipid deprivation increases mRNA synthesis for CCT [Ryan, McCoy, Mathur, Field and Mallampalli (2000) J. Lipid Res. 41, 1268-1277]. To evaluate regulatory mechanisms for this gene, we cloned the proximal approximately 1900 bp of the 5' flanking sequence of the murine CCT gene, coupled this to a luciferase reporter, and examined transcriptional regulation in a murine alveolar epithelial type II cell line (MLE-12). The core promoter was localized to a region between -169 and +71 bp, which exhibited strong basal activity comparable with the simian virus 40 promoter. The full-length construct, from -1867 to +71, was induced 2-3-fold when cells were cultured in lipoprotein-deficient serum (LPDS), similar to the level of induction of the endogenous CCT gene. By deletional analysis the sterol regulatory element (SRE) was localized within a 240 bp region. LPDS activation of the CCT promoter was abolished by mutation of this SRE, and gel mobility-shift assays demonstrated specific binding of recombinant SRE-binding protein to this element within the CCT promoter. These observations indicate that sterol-regulated expression of CCT is mediated by an SRE within its 5' flanking region. JF - The Biochemical journal AU - Mallampalli, Rama K AU - Ryan, Alan J AU - Carroll, James L AU - Osborne, Timothy F AU - Thomas, Christie P AD - The Veterans Administration Medical Center, Iowa City, IA 52246, U.S.A. rama-mallampalli@uiowa.edu Y1 - 2002/02/15/ PY - 2002 DA - 2002 Feb 15 SP - 81 EP - 88 VL - 362 SN - 0264-6021, 0264-6021 KW - DNA Primers KW - 0 KW - Phosphatidylcholines KW - Sterols KW - Surface-Active Agents KW - Choline-Phosphate Cytidylyltransferase KW - EC 2.7.7.15 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - Base Sequence KW - Blotting, Northern KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Mice KW - Regulatory Sequences, Nucleic Acid KW - Promoter Regions, Genetic KW - Sterols -- metabolism KW - Phosphatidylcholines -- biosynthesis KW - Surface-Active Agents -- metabolism KW - Lipid Metabolism KW - Choline-Phosphate Cytidylyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71467897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Biochemical+journal&rft.atitle=Lipid+deprivation+increases+surfactant+phosphatidylcholine+synthesis+via+a+sterol-sensitive+regulatory+element+within+the+CTP%3Aphosphocholine+cytidylyltransferase+promoter.&rft.au=Mallampalli%2C+Rama+K%3BRyan%2C+Alan+J%3BCarroll%2C+James+L%3BOsborne%2C+Timothy+F%3BThomas%2C+Christie+P&rft.aulast=Mallampalli&rft.aufirst=Rama&rft.date=2002-02-15&rft.volume=362&rft.issue=&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=The+Biochemical+journal&rft.issn=02646021&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-22 N1 - Date created - 2002-02-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1997 Apr 15;99(8):2020-9 [9109447] J Biol Chem. 1999 May 7;274(19):13025-32 [10224053] Mol Cell Biol. 1997 Sep;17(9):5193-200 [9271397] J Biol Chem. 1998 Jan 16;273(3):1349-56 [9430668] J Appl Physiol (1985). 2000 Jan;88(1):10-6 [10642356] J Biol Chem. 2000 Mar 31;275(13):9699-708 [10734122] J Biol Chem. 2000 Apr 28;275(17):12497-502 [10777536] J Lipid Res. 2000 Aug;41(8):1268-77 [10946015] Mol Endocrinol. 2001 Apr;15(4):575-88 [11266509] J Biol Chem. 2001 Apr 13;276(15):12338-44 [11279002] Anal Biochem. 1970 Jul;36(1):225-6 [5482631] Biochim Biophys Acta. 1976 Jun 22;431(3):399-407 [988841] Biochim Biophys Acta. 1976 Sep 27;441(3):412-22 [9987] Respir Physiol. 1978 Feb;32(2):195-206 [580481] Biochem J. 1978 Aug 15;174(2):535-41 [708406] Biochim Biophys Acta. 1981 Mar 23;663(3):621-9 [7225402] Anat Rec. 1982 Jan;202(1):23-31 [7199264] Lipids. 1982 Jan;17(1):42-5 [7087681] J Lipid Res. 1983 Dec;24(12):1651-6 [6689421] Lipids. 1984 Jan;19(1):38-43 [6546777] Exp Lung Res. 1984;6(2):133-47 [6547669] Biochim Biophys Acta. 1985 Mar 6;833(3):429-37 [2982417] J Appl Physiol (1985). 1986 May;60(5):1610-4 [3754859] Am Rev Respir Dis. 1987 May;135(5):991-6 [3579020] J Biol Chem. 1987 Aug 5;262(22):10773-9 [3611089] J Biol Chem. 1988 Mar 5;263(7):3372-9 [3277969] Biochim Biophys Acta. 1988 Mar 4;959(1):1-8 [3345311] Am J Physiol. 1989 Oct;257(4 Pt 1):L195-201 [2679140] Biochim Biophys Acta. 1989 Dec 18;1006(3):329-34 [2574595] Pediatr Res. 1991 Mar;29(3):288-91 [2034477] J Biol Chem. 1992 Jan 25;267(3):1752-60 [1309795] In Vitro Cell Dev Biol. 1992 Mar;28A(3 Pt 1):181-7 [1316350] J Biol Chem. 1993 Dec 5;268(34):25487-93 [8244984] Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11029-33 [8248207] Am J Physiol. 1994 Dec;267(6 Pt 1):L641-8 [7810669] J Biol Chem. 1995 Jan 20;270(3):1161-9 [7836375] Food Chem Toxicol. 1995 Mar;33(3):233-7 [7896234] Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6102-6 [7597088] J Biol Chem. 1995 Sep 15;270(37):21958-65 [7665618] J Biol Chem. 1995 Oct 27;270(43):25578-83 [7592729] J Biol Chem. 1995 Dec 15;270(50):29894-903 [8530387] Acta Vet Hung. 1995;43(2-3):303-9 [7491870] Arch Toxicol. 1995;69(6):405-9 [7495379] Am J Physiol. 1997 Mar;272(3 Pt 1):L479-85 [9124605] Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):4935-40 [9560206] J Biol Chem. 1998 May 29;273(22):14022-9 [9593753] Proc Natl Acad Sci U S A. 1998 May 26;95(11):5987-92 [9600904] J Biol Chem. 1999 Apr 30;274(18):12431-7 [10212217] Biochim Biophys Acta. 1999 Apr 19;1438(1):147-65 [10216289] Can J Biochem Physiol. 1959 Aug;37(8):911-7 [13671378] Cell. 1997 May 2;89(3):331-40 [9150132] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Department of Veterans Affairs Cooperative Studies Program Clinical Trial comparing combined warfarin and aspirin with aspirin alone in survivors of acute myocardial infarction: primary results of the CHAMP study. AN - 71489022; 11827919 AB - Both aspirin and warfarin when used alone are effective in the secondary prevention of vascular events and death after acute myocardial infarction. We tested the hypothesis that aspirin and warfarin therapy, when combined, would be more effective than aspirin monotherapy. Methods and Results- We conducted a randomized open-label study to compare the efficacy of warfarin (target international normalized ratio 1.5 to 2.5 IU) plus aspirin (81 mg daily) with the efficacy of aspirin monotherapy (162 mg daily) in reducing the total mortality in 5059 patients enrolled within 14 days of infarction and followed for a median of 2.7 years. Secondary end points included recurrent myocardial infarction, stroke, and major hemorrhage. Four hundred thirty-eight (17.3%) of 2537 patients assigned to the aspirin group and 444 (17.6%) of 2522 patients assigned to the combination group died (log-rank P=0.76). Recurrent myocardial infarction occurred in 333 patients (13.1%) taking aspirin and in 336 patients (13.3%) taking combination therapy (log-rank P=0.78). Stroke occurred in 89 patients (3.5%) taking aspirin and in 79 patients (3.1%) taking combination therapy (log-rank P=0.52). Major bleeding occurred more frequently in the combination therapy group than in the aspirin group (1.28 versus 0.72 events per 100 person years of follow-up, respectively; P<0.001). There were 14 individuals with intracranial bleeds in both the aspirin and combination therapy groups. In post-myocardial infarction patients, warfarin therapy (at a mean international normalized ratio of 1.8) combined with low-dose aspirin did not provide a clinical benefit beyond that achievable with aspirin monotherapy. JF - Circulation AU - Fiore, Louis D AU - Ezekowitz, Michael D AU - Brophy, Mary T AU - Lu, David AU - Sacco, Joseph AU - Peduzzi, Peter AU - Combination Hemotherapy and Mortality Prevention (CHAMP) Study Group AD - Department of Veterans Affairs Cooperative Studies Program Coordinating Center, West Haven, Connecticut, USA. louis.fiore@med.va.gov ; Combination Hemotherapy and Mortality Prevention (CHAMP) Study Group Y1 - 2002/02/05/ PY - 2002 DA - 2002 Feb 05 SP - 557 EP - 563 VL - 105 IS - 5 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Anticoagulants KW - Warfarin KW - 5Q7ZVV76EI KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - International Normalized Ratio -- statistics & numerical data KW - Humans KW - Hemorrhage -- etiology KW - Risk Assessment KW - Drug Therapy, Combination KW - Survival Rate KW - Treatment Outcome KW - Follow-Up Studies KW - Middle Aged KW - Female KW - Male KW - Hospitals, Veterans KW - Proportional Hazards Models KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Aspirin -- adverse effects KW - Anticoagulants -- therapeutic use KW - Anticoagulants -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Aspirin -- therapeutic use KW - Warfarin -- adverse effects KW - Warfarin -- therapeutic use KW - Myocardial Infarction -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71489022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation&rft.atitle=Department+of+Veterans+Affairs+Cooperative+Studies+Program+Clinical+Trial+comparing+combined+warfarin+and+aspirin+with+aspirin+alone+in+survivors+of+acute+myocardial+infarction%3A+primary+results+of+the+CHAMP+study.&rft.au=Fiore%2C+Louis+D%3BEzekowitz%2C+Michael+D%3BBrophy%2C+Mary+T%3BLu%2C+David%3BSacco%2C+Joseph%3BPeduzzi%2C+Peter%3BCombination+Hemotherapy+and+Mortality+Prevention+%28CHAMP%29+Study+Group&rft.aulast=Fiore&rft.aufirst=Louis&rft.date=2002-02-05&rft.volume=105&rft.issue=5&rft.spage=557&rft.isbn=&rft.btitle=&rft.title=Circulation&rft.issn=1524-4539&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-12 N1 - Date created - 2002-02-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Fam Pract. 2002 Jun;51(6):518 [12100773] ACP J Club. 2002 Sep-Oct;137(2):47 [12207425] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oropharyngeal deglutition in stable COPD. AN - 85250666; pmid-11834644 AB - STUDY OBJECTIVES: The aim of this study was to examine deglutition in stable patients with COPD and lung hyperinflation. DESIGN: Twenty consecutive, eligible COPD patients with an FEV(1) or = 120% of predicted were enrolled prospectively. INTERVENTION: Patients received a detailed videofluoroscopic evaluation of oropharyngeal swallowing and were compared to 20 age-matched and sex-matched historical control subjects. SETTING: An outpatient pulmonary clinic at a Veterans Affairs Medical Center. MEASUREMENTS AND RESULTS: The mean total lung capacity, functional residual capacity, and residual volume for the patients were 128% of predicted, 168% of predicted, and 218% of predicted, respectively. The mean FEV(1) was 39% of predicted. There was no evidence of tracheal aspiration in either group. The laryngeal position at rest measured relative to the cervical vertebrae was not different between groups. The maximal laryngeal elevation during swallowing was significantly lower in patients with COPD (p < 0.001). Patients with COPD exhibited more frequent use of spontaneous protective swallowing maneuvers such as longer duration of airway closure and earlier laryngeal closure relative to the cricopharyngeal opening than did control subjects (p < 0.05). CONCLUSIONS: We conclude that hyperinflated patients with COPD have an altered swallowing physiology. We suspect that the protective alterations in swallowing physiology (swallow maneuvers) may reduce the risk of aspiration. However, these swallowing maneuvers may not be useful during an exacerbation and may require further research. JF - Chest AU - Mokhlesi Babak AU - Logemann, Jeri A AU - Rademaker, Alfred W AU - Stangl, Carrie A AU - Corbridge, Thomas C AD - Division of Pulmonary and Critical Care, Northwestern University Medical School and the Veterans Administration Chicago Healthcare System-Lakeside Division, IL, USA. PY - 2002 SP - 361 EP - 369 VL - 121 IS - 2 SN - 0012-3692, 0012-3692 KW - Prospective Studies KW - Support, U.S. Gov't, P.H.S. KW - Oropharynx KW - Residual Volume KW - Functional Residual Capacity KW - Lung KW - Human KW - Aged KW - Total Lung Capacity KW - Deglutition KW - Male KW - Female KW - Pulmonary Disease, Chronic Obstructive UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85250666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Oropharyngeal+deglutition+in+stable+COPD.&rft.au=Mokhlesi+Babak%3BLogemann%2C+Jeri+A%3BRademaker%2C+Alfred+W%3BStangl%2C+Carrie+A%3BCorbridge%2C+Thomas+C&rft.aulast=Mokhlesi+Babak&rft.aufirst=&rft.date=2002-02-01&rft.volume=121&rft.issue=2&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - The subjective effects of nicotine: methodological issues, a review of experimental studies, and recommendations for future research. AN - 71533269; 11906682 AB - This paper reviews findings from placebo-controlled human experimental studies of the effects of nicotine on subjective experience. Studies are grouped according to whether participants were smokers (significantly nicotine deprived, minimally nicotine deprived) or non-smokers. Within each category, studies are also grouped according to method of nicotine administration (e.g., smoked tobacco, nasal spray) and nicotine dose. This review of studies is preceded by a discussion of several methodological issues in studies of nicotine and mood. The principal findings of this review are: (1) there is a linear relationship between nicotine dose and measures of drug high (e.g., head rush, euphoria) in significantly nicotine-deprived smokers; (2) there appear to be few positive or negative main effects of nicotine on mood in minimally nicotine-deprived smokers; (3) nicotine has positive effects (e.g., increases head rush) and negative effects (e.g., increases tension) in non-smokers; (4) stronger effects of nicotine on mood emerge when individual difference variables (e.g., neuroticism) and situational contingencies (e.g., exposure to stressful stimuli) are examined. Additional studies with minimally nicotine-deprived smokers and non-smokers are needed to further specify the conditions under which nicotine affects mood and other subjective experience. The review concludes with a discussion of putative mechanisms that may mediate the interaction between nicotine and moderating variables on affect and with suggestions for future research. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Kalman, David AD - Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA. Kalman.David@bedford.va.gov Y1 - 2002/02// PY - 2002 DA - February 2002 SP - 25 EP - 70 VL - 4 IS - 1 SN - 1462-2203, 1462-2203 KW - Ganglionic Stimulants KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Smoking KW - Administration, Cutaneous KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Humans KW - Administration, Intranasal KW - Gingiva KW - Injections, Subcutaneous KW - Research Design KW - Tobacco Use Disorder -- psychology KW - Nicotine -- administration & dosage KW - Affect KW - Ganglionic Stimulants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71533269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=The+subjective+effects+of+nicotine%3A+methodological+issues%2C+a+review+of+experimental+studies%2C+and+recommendations+for+future+research.&rft.au=Kalman%2C+David&rft.aulast=Kalman&rft.aufirst=David&rft.date=2002-02-01&rft.volume=4&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-13 N1 - Date created - 2002-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Apheresis in cryoglobulinemia complicating hepatitis C and in other renal diseases. AN - 71500552; 11886579 AB - Removal of cryoglobulins by plasma exchange is now an accepted therapy. Cryoglobulins are circulating complexes that can deposit on small vessels and cause limited or extensive tissue injury. There are 3 major classes of cryoglobulins. Type I cryoglobulins are monoclonal and are detected in a variety of lymphoproliferative disorders. Type II cryoglobulins are mixed containing monoclonal and polyclonal IgG or IgM molecules. Type III cryoglobulins are also mixed and contain polyclonal IgG. Type II cryoglobulins are largely caused by hepatitis C virus infection; hence, they are the most common of the 3 types. In hepatitis C, cryoglobulins are linked to glomerular immune complex injury, often times accompanied by vasculitis of the skin, nerves, and other vital organs. Immediate removal of cryoglobulins by plasma exchange is an effective short-term treatment that can complement more-specific therapies. Plasma exchange has also been used to remove other circulating nephrotoxic agents such as antiglomerular basement antibodies that cause Goodpasture's syndrome, protease inhibitor autoantibodies that cause thrombotic thrombocytopenic purpura, and antiglomerular factors that cause some types of focal glomerulosclerosis. JF - Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis AU - Dominguez, Jesus H AU - Sha, Edward AD - Department of Medicine, Indiana University and Veterans Administration Medical Center, Indianapolis, Indiana, USA. Jhdoming@iupui.edu Y1 - 2002/02// PY - 2002 DA - February 2002 SP - 69 EP - 76 VL - 6 IS - 1 SN - 1091-6660, 1091-6660 KW - Index Medicus KW - Humans KW - Hepatitis C -- complications KW - Blood Component Removal KW - Kidney Diseases -- complications KW - Cryoglobulinemia -- etiology KW - Plasma Exchange KW - Kidney Diseases -- therapy KW - Cryoglobulinemia -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71500552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Therapeutic+apheresis+%3A+official+journal+of+the+International+Society+for+Apheresis+and+the+Japanese+Society+for+Apheresis&rft.atitle=Apheresis+in+cryoglobulinemia+complicating+hepatitis+C+and+in+other+renal+diseases.&rft.au=Dominguez%2C+Jesus+H%3BSha%2C+Edward&rft.aulast=Dominguez&rft.aufirst=Jesus&rft.date=2002-02-01&rft.volume=6&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Therapeutic+apheresis+%3A+official+journal+of+the+International+Society+for+Apheresis+and+the+Japanese+Society+for+Apheresis&rft.issn=10916660&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-04-18 N1 - Date created - 2002-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Common mechanisms and strategies for prevention and treatment of cardiac arrest during epidural anesthesia. AN - 71496876; 11880024 AB - Cardiac arrests continue to occur during epidural anesthesia and frequently result in death or brain damage. Although unintentional "total spinal" anesthesia, respiratory depression, myocardial ischemia, and local anesthetic toxicity can also lead to cardiac arrest, often the arrests do not fit any of these four categories. Many of the unexplained arrests may be attributed to vagal predominance. The evidence for a vagal-linked circulatory mechanism for these arrests is reviewed, and the characteristics that are associated with an increased risk for cardiac arrest during epidural anesthesia are identified. Specific strategies to forestall vagal predominance are discussed. In case these strategies fail, multiple interventions are discussed that should increase the likelihood of a successful resuscitation in the setting of extensive sympathetic blockade. JF - Journal of clinical anesthesia AU - Pollard, John B AD - Department of Anesthesiology, Veterans Affairs Palo Alto Health Care System and Stanford University School of Medicine, Stanford, CA 94304-1207, USA. john.pollard@med.va.gov Y1 - 2002/02// PY - 2002 DA - February 2002 SP - 52 EP - 56 VL - 14 IS - 1 SN - 0952-8180, 0952-8180 KW - Index Medicus KW - Risk Factors KW - Humans KW - Resuscitation KW - Heart Arrest -- prevention & control KW - Heart Arrest -- physiopathology KW - Anesthesia, Epidural -- adverse effects KW - Heart Arrest -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71496876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+anesthesia&rft.atitle=Common+mechanisms+and+strategies+for+prevention+and+treatment+of+cardiac+arrest+during+epidural+anesthesia.&rft.au=Pollard%2C+John+B&rft.aulast=Pollard&rft.aufirst=John&rft.date=2002-02-01&rft.volume=14&rft.issue=1&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+anesthesia&rft.issn=09528180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-04-18 N1 - Date created - 2002-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lupus nephritis: a clinical review for practicing nephrologists. AN - 71481696; 11863131 AB - The renal manifestations in systemic lupus erythematosus (SLE) are protean and difficult to categorize into clinical syndromes and histologic classes. Lupus nephritis is frequently unrecognized until full-blown nephritic and/or nephrotic syndrome with renal failure emerge. Epidemiologically, approximately one third of SLE patients from unselected populations have renal involvement early during the disease. Most renal abnormalities emerge within the first few years of SLE diagnosis. Currently, most nephrologists agree that an early renal biopsy is worthwhile in those SLE patients with abnormal urinalysis and/or reduced renal function. First, it provides a histologic categorization of the glomerulonephritis as well as an assessment of the degree of activity and chronicity. Second, it provides vital prognostic information. Third, it is beneficial in planning a more rational therapy with or without potentially toxic immunosuppressive agents. Over the last 3 decades, many controlled clinical trials for treatment of lupus nephritis have been completed with a few therapeutic immunosuppressive regimens. Among those agents used. cyclophosphamide and azathioprine provide a reduction of morbidity in those patients afflicted with proliferative forms of lupus glomerulonephritis. A new immunosuppressive agent, mycophenolate mofetil, is being studied for treatment of proliferative forms of lupus glomerulonephritis in a controlled clinical trial at our institution. Immunosuppressive agents and the availability of dialysis and transplantation have improved the survival of patients with lupus nephritis, in particular those with proliferative forms. JF - Clinical nephrology AU - Contreras, G AU - Roth, D AU - Pardo, V AU - Striker, L G AU - Schultz, D R AD - Dialysis Unit VAMC, Veterans Affairs Medical Center and University of Miami School of Medicine, FL 33125, USA. Gabriel.Contreras@med.va.gov Y1 - 2002/02// PY - 2002 DA - February 2002 SP - 95 EP - 107 VL - 57 IS - 2 SN - 0301-0430, 0301-0430 KW - Immunosuppressive Agents KW - 0 KW - Index Medicus KW - Humans KW - Immunosuppressive Agents -- therapeutic use KW - Lupus Nephritis -- therapy KW - Lupus Nephritis -- physiopathology KW - Lupus Nephritis -- classification KW - Lupus Nephritis -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71481696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+nephrology&rft.atitle=Lupus+nephritis%3A+a+clinical+review+for+practicing+nephrologists.&rft.au=Contreras%2C+G%3BRoth%2C+D%3BPardo%2C+V%3BStriker%2C+L+G%3BSchultz%2C+D+R&rft.aulast=Contreras&rft.aufirst=G&rft.date=2002-02-01&rft.volume=57&rft.issue=2&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Clinical+nephrology&rft.issn=03010430&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-08-15 N1 - Date created - 2002-02-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Terazosin for treating symptomatic benign prostatic obstruction: a systematic review of efficacy and adverse effects. AN - 71465947; 11856101 AB - To systematically review and evaluate the effectiveness and adverse effects of the alpha-antagonist, terazosin, for treating urinary symptoms associated with benign prostatic obstruction (BPO). Studies were sought and included in the review if they were randomized trials of at least 1 month duration, involved men with symptomatic BPO and compared terazosin with placebo or active controls. The study, patient characteristics and outcome data were extracted in duplicate onto standardized forms using a prospectively developed protocol. Seventeen studies involving 5151 men met the inclusion criteria, i.e. placebo-controlled (10), alpha-blockers (seven), finasteride alone or combined with terazosin and placebo (one), and microwave therapy (one). The study duration was 4-52 weeks; the mean age of the men was 65 years and 82% were white. Baseline urological symptom scale scores and flow rates showed that men had moderate BPO. Efficacy outcomes were rarely reported in a way that allowed for data pooling, but indicated that terazosin improved symptom scores and flow rates more than did placebo or finasteride, and similarly to other alpha-antagonists. The pooled mean percentage improvement for the Boyarsky symptom score was 37% for terazosin and 15% for placebo (four studies). The mean percentage improvement for the American Urological Association symptom score was 38%, compared with 17% and 20% for placebo and finasteride, respectively (two studies). The pooled mean improvement in the International Prostate Symptom Score of 40% was similar to that with tamsulosin (43%). Peak urinary flow rates improved more with terazosin (22%) than with placebo (11%) and finasteride (15%), but did not differ significantly from the other alpha-antagonists. The percentage of men discontinuing terazosin was comparable with those receiving placebo and finasteride, but greater than with other alpha-antagonists. Adverse effects were greater than with placebo and included dizziness, asthenia, headache and postural hypotension. The available evidence indicates that terazosin improves the symptoms and flow rates associated with BPO; it was more effective than placebo or finasteride and similar to other alpha-antagonists. Adverse effects were generally mild but more frequent than with other alpha-antagonists and associated with a two- to four-fold increase in treatment discontinuation. JF - BJU international AU - Wilt, T J AU - Howe, W AU - MacDonald, R AD - Minneapolis VA Center for Chronic Disease Outcomes Research, the Cochrane Review Group in Prostate Diseases and Urologic Cancers, VA Medical Center, Minneapolis, USA. tim.wilt@med.va.gov Y1 - 2002/02// PY - 2002 DA - February 2002 SP - 214 EP - 225 VL - 89 IS - 3 SN - 1464-4096, 1464-4096 KW - Adrenergic alpha-Antagonists KW - 0 KW - Drug Combinations KW - Enzyme Inhibitors KW - Sulfonamides KW - Finasteride KW - 57GNO57U7G KW - tamsulosin KW - G3P28OML5I KW - Index Medicus KW - Enzyme Inhibitors -- adverse effects KW - Randomized Controlled Trials as Topic KW - Enzyme Inhibitors -- therapeutic use KW - Urination -- physiology KW - Humans KW - Patient Dropouts KW - Finasteride -- adverse effects KW - Finasteride -- therapeutic use KW - Quality of Life KW - Aged KW - Male KW - Prostatic Hyperplasia -- drug therapy KW - Adrenergic alpha-Antagonists -- therapeutic use KW - Sulfonamides -- adverse effects KW - Urinary Retention -- etiology KW - Prostatic Hyperplasia -- pathology KW - Urinary Retention -- drug therapy KW - Sulfonamides -- therapeutic use KW - Adrenergic alpha-Antagonists -- adverse effects KW - Prostatic Hyperplasia -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71465947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BJU+international&rft.atitle=Terazosin+for+treating+symptomatic+benign+prostatic+obstruction%3A+a+systematic+review+of+efficacy+and+adverse+effects.&rft.au=Wilt%2C+T+J%3BHowe%2C+W%3BMacDonald%2C+R&rft.aulast=Wilt&rft.aufirst=T&rft.date=2002-02-01&rft.volume=89&rft.issue=3&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=BJU+international&rft.issn=14644096&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-03-22 N1 - Date created - 2002-02-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bupropion-induced acute dystonia. AN - 71464997; 11847943 AB - To report a case of acute dystonia consisting of neck stiffness, trismus, and unilateral temporomandibular joint (TMJ) pain and subluxation secondary to an increase in sustained-release (SR) bupropion. A 44-year-old white man with a history of chronic low-back pain and tension headaches, taking no other medications, was started on bupropion SR 150 mg once a day for depression. The dosage was increased to 150 mg SR twice a day and eventually augmented with buspirone 15 mg 3 times a day. He developed bilateral trismus, inability to rotate his head laterally, and spontaneous left TMJ subluxation. Symptoms recessed with discontinuation of both medications and failed to reappear with a trial of buspirone 15 mg 3 times a day alone. A retrial of bupropion alone evidenced no adverse effects at a dosage of 150 mg SR once a day. However, when the dosage was increased to 150 mg SR twice a day, the patient reexperienced initial signs of neck stiffness, jaw muscle tightness, and left TMJ subluxation within 24-48 hours. Reduction of the bupropion dosage to 150 mg SR once daily stopped the symptoms; the patient has continued at this dosage without adverse effects for > 1 year. Medication-induced focal dystonias usually present with dramatic head (most frequently oral-buccal) and neck muscle spasm with occasional jaw clenching, bruxism, and TMJ syndrome. In this case, the rapid onset of neck and jaw symptoms within 24-48 hours of an increase of bupropion SR from 150 mg once a day to 150 mg twice a day suggest that the patient may have been sensitized by an initial trial of bupropion and buspirone, or by the increased dose of bupropion alone. Both agents are reported to interact with both the dopaminergic and serotonergic systems. Although buspirone has been implicated in inducing acute dystonia, it did not do so in this case when used alone at a dose of 45 mg a day. During a second trial of bupropion SR 150 mg a day, neck and jaw symptoms recurred within 24-48 hours of increasing the dose to 150 mg SR twice a day. The symptoms receded when the bupropion dose was returned to 150 mg SR once a day, suggesting a dose-response relationship. The Naranjo probability scale indicated that this untoward reaction was probable. This case suggests that selected patients may experience dose-related acute dystonic adverse reactions to bupropion with or without buspirone augmentation. Dystonias, which usually follow administration of antipsychotics, have been linked to acute dopamine depletion and basal ganglion-derived gamma synchronization dysfunction. Acute dystonia symptoms may begin within hours of starting or changing antipsychotic drug dosage; however, 90% of symptoms are observed during the first 3-5 days of starting or increasing dosage. To the best of our knowledge, there have been no reports of bupropion-induced dystonia. JF - The Annals of pharmacotherapy AU - Detweiler, Mark B AU - Harpold, Gary J AD - Department of Psychiatric Medicine (116A7), Salem Veterans Affairs Medical Center, University of Virginia, Salem-Roanoke, 1970 Roanoke Blvd., Salem, VA 24153-6478, USA. Detweiler.Mark_B@Salem.VA.Gov Y1 - 2002/02// PY - 2002 DA - February 2002 SP - 251 EP - 254 VL - 36 IS - 2 SN - 1060-0280, 1060-0280 KW - Dopamine Uptake Inhibitors KW - 0 KW - Serotonin Receptor Agonists KW - Bupropion KW - 01ZG3TPX31 KW - Buspirone KW - TK65WKS8HL KW - Index Medicus KW - Acute Disease KW - Serotonin Receptor Agonists -- adverse effects KW - Dose-Response Relationship, Drug KW - Buspirone -- therapeutic use KW - Humans KW - Buspirone -- administration & dosage KW - Adult KW - Buspirone -- adverse effects KW - Serotonin Receptor Agonists -- therapeutic use KW - Depression -- drug therapy KW - Male KW - Bupropion -- therapeutic use KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Dystonia -- chemically induced KW - Dopamine Uptake Inhibitors -- adverse effects KW - Dopamine Uptake Inhibitors -- therapeutic use KW - Bupropion -- adverse effects KW - Bupropion -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71464997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+pharmacotherapy&rft.atitle=Bupropion-induced+acute+dystonia.&rft.au=Detweiler%2C+Mark+B%3BHarpold%2C+Gary+J&rft.aulast=Detweiler&rft.aufirst=Mark&rft.date=2002-02-01&rft.volume=36&rft.issue=2&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+pharmacotherapy&rft.issn=10600280&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-08-12 N1 - Date created - 2002-02-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Generalized hyperpigmentation with daunorubicin chemotherapy. AN - 71414684; 11807454 AB - Daunorubicin has been reported to cause hyperpigmentation of sun-exposed skin and/or transverse nail pigmentation (3 cases). We report a case of an African American man who had an atypical pattern of generalized hyperpigmentation develop that involved many sun-protected skin areas 2 weeks after daunorubicin treatment. Histopathology of hyperpigmented skin showed increased melanin granules in all epidermal layers. The mechanisms by which daunorubicin may increase skin pigmentation are discussed. JF - Journal of the American Academy of Dermatology AU - Kroumpouzos, George AU - Travers, Robin AU - Allan, Anne AD - Department of Dermatology, Boston Medical Center, Boston University School of Medicine, MA, USA. kroumpouzos.george@boston.va.gov Y1 - 2002/02// PY - 2002 DA - February 2002 SP - S1 EP - S3 VL - 46 IS - 2 Suppl Case Reports SN - 0190-9622, 0190-9622 KW - Antibiotics, Antineoplastic KW - 0 KW - Daunorubicin KW - ZS7284E0ZP KW - Index Medicus KW - Humans KW - Adult KW - African Continental Ancestry Group KW - Male KW - Leukemia, Myeloid, Acute -- drug therapy KW - Hyperpigmentation -- pathology KW - Daunorubicin -- adverse effects KW - Hyperpigmentation -- chemically induced KW - Antibiotics, Antineoplastic -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71414684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Generalized+hyperpigmentation+with+daunorubicin+chemotherapy.&rft.au=Kroumpouzos%2C+George%3BTravers%2C+Robin%3BAllan%2C+Anne&rft.aulast=Kroumpouzos&rft.aufirst=George&rft.date=2002-02-01&rft.volume=46&rft.issue=2+Suppl+Case+Reports&rft.spage=S1&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=01909622&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-26 N1 - Date created - 2002-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Efficient trial design for eliciting a pharmacokinetic-pharmacodynamic model-based response surface describing the interaction between two intravenous anesthetic drugs. AN - 71412236; 11818774 AB - The authors published a pharmacokinetic- pharmacodynamic model for two drugs based on response surface methodology. Because of the complexity of the model, they performed a simulation study to answer two questions about use of the model: (1) which study design would be most satisfactory; and (2) how many patients would need to be studied to adequately describe an entire response surface. Data were simulated using realistic variability for two hypothetical intravenous anesthetic drugs that interact synergistically and that could be given by computer-controlled infusion. Three trial designs were simulated, one that made a series of parallel slices of the response surface, one that crisscrossed the response surface, and one that made a series of radial slices across the surface. Series of 5, 10, 20, and 40 "subjects" were simulated. A pooled data approach was used to assess the ability of the various trial designs and numbers of subjects to adequately identify the interaction response surface and estimate the original response surface. The crisscross design was shown to be the most robust in terms of its ability to both discriminate the correct order of the interaction term and to discriminate the original response surface using the least number of patients. Twenty subjects would be required to adequately define a surface using the crisscross study design, and 40 subjects would be required using the other trial designs. The results showed that a number of trial designs would be viable, but a design that crossed the surface in a crisscross fashion would give the most robust result with the least patients. JF - Anesthesiology AU - Short, Timothy G AU - Ho, Tam Yuk AU - Minto, Charles F AU - Schnider, Thomas W AU - Shafer, Steven L AD - Palo Alto Veterans Administration Health Care Center, Palo Alto, California, USA. tims@adhb.govt.nz Y1 - 2002/02// PY - 2002 DA - February 2002 SP - 400 EP - 408 VL - 96 IS - 2 SN - 0003-3022, 0003-3022 KW - Anesthetics, Intravenous KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Computer Simulation KW - Nonlinear Dynamics KW - Algorithms KW - Drug Synergism KW - Research Design KW - Models, Biological KW - Anesthetics, Intravenous -- pharmacology KW - Anesthetics, Intravenous -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71412236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesiology&rft.atitle=Efficient+trial+design+for+eliciting+a+pharmacokinetic-pharmacodynamic+model-based+response+surface+describing+the+interaction+between+two+intravenous+anesthetic+drugs.&rft.au=Short%2C+Timothy+G%3BHo%2C+Tam+Yuk%3BMinto%2C+Charles+F%3BSchnider%2C+Thomas+W%3BShafer%2C+Steven+L&rft.aulast=Short&rft.aufirst=Timothy&rft.date=2002-02-01&rft.volume=96&rft.issue=2&rft.spage=400&rft.isbn=&rft.btitle=&rft.title=Anesthesiology&rft.issn=00033022&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-04-02 N1 - Date created - 2002-01-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Acta Anaesthesiol Taiwan. 2015 Dec;53(4):139-45 [26321504] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Implementation of an X-ray radiation protective equipment inspection program. AN - 71409374; 11797906 AB - In order to comply with the requirements established by healthcare organization accrediting agencies, radiation protective equipment (e.g., lead aprons, gloves, and collars) utilized by x-ray workers must be periodically evaluated for damage. The objective of such evaluations is to identify and remove from service equipment bearing large holes, tears, etc., that could compromise the safety of individuals using this equipment. Many facilities are cited each year for failing to ensure the availability and integrity of such equipment. Unfortunately, written guidance on the proper implementation of inspection programs is not readily available. This paper was developed to assist healthcare organization safety personnel in establishing a radiation protective equipment inspection program at their facilities. JF - Health physics AU - Michel, René AU - Zorn, Michael J AD - VA San Diego Healthcare System, CA 92161, USA. rene.michel@med.va.gov Y1 - 2002/02// PY - 2002 DA - February 2002 SP - S51 EP - S53 VL - 82 IS - 2 Suppl SN - 0017-9078, 0017-9078 KW - Index Medicus KW - Humans KW - Equipment Failure KW - Occupational Health KW - X-Rays KW - Occupational Exposure -- prevention & control KW - Radiology Department, Hospital -- standards KW - Radiation Protection -- instrumentation KW - Radiation Protection -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71409374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Implementation+of+an+X-ray+radiation+protective+equipment+inspection+program.&rft.au=Michel%2C+Ren%C3%A9%3BZorn%2C+Michael+J&rft.aulast=Michel&rft.aufirst=Ren%C3%A9&rft.date=2002-02-01&rft.volume=82&rft.issue=2+Suppl&rft.spage=S51&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-31 N1 - Date created - 2002-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effective treatment of experimental DU-145 prostate cancers with targeted cytotoxic somatostatin analog AN-238. AN - 71369134; 11788908 AB - We evaluated the effectiveness of targeted cytotoxic analog of somatostatin (SST) AN-238, consisting of 2-pyrrolinodoxorubicin (AN-201) linked covalently to SST octapeptide carrier RC-121 in DU-145 human androgen-independent prostate cancers xenografted into nude mice. We also investigated the expression of mRNAs for SST receptor subtypes 2A and 5 (sst2A and sst5) in DU-145 tumors. After 8 weeks of treatment, AN-238 practically arrested the proliferation of DU-145 cancers. The tumor volume in nude mice that received 4 injections of AN-238 at the dose of 150 nmol/kg was 63.4+/-6.7 mm3, nearly 4 times smaller than that in controls which measured 249.1+/-36.3 mm3 (p<0.001). Treatment with AN-238 lowered tumor weight by 68% (p<0.01) compared with the control group and extended the tumor volume doubling time to 184.1+/-69.4 days, versus 32.1+/-6.6 days in controls (p<0.05). No toxicity-related deaths occurred during treatment with AN-238. Cytotoxic radical AN-201 administered alone or in an unconjugated mixture with carrier RC-121 inhibited the growth of DU-145 tumors only after the third and fourth injection and was toxic. The expression of mRNA for sst2A and sst5 was detected in all specimens of control DU-145 tumors and in tumors treated with AN-238. The present study demonstrates the high efficacy of SST-receptor-targeted chemotherapy in a model of human androgen-independent prostatic carcinoma. JF - International journal of oncology AU - Plonowski, Artur AU - Schally, Andrew V AU - Nagy, Attila AU - Sun, Baodong AU - Halmos, Gabor AD - Endocrine, Polypeptide and Cancer Institute, Veterans Administration Medical Center, New Orleans, LA 70-112-1262, USA. Y1 - 2002/02// PY - 2002 DA - February 2002 SP - 397 EP - 402 VL - 20 IS - 2 SN - 1019-6439, 1019-6439 KW - AN 238 KW - 0 KW - Antibiotics, Antineoplastic KW - Cytotoxins KW - Pyrroles KW - RNA, Messenger KW - RNA, Neoplasm KW - AN 204 KW - 175795-76-3 KW - Doxorubicin KW - 80168379AG KW - RC 121 KW - 99660-13-6 KW - Octreotide KW - RWM8CCW8GP KW - Index Medicus KW - Animals KW - Humans KW - Cell Division -- drug effects KW - Mice KW - Mice, Nude KW - RNA, Neoplasm -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Antibiotics, Antineoplastic -- therapeutic use KW - Gene Expression Regulation, Neoplastic KW - Neoplasm Transplantation KW - Tumor Cells, Cultured KW - RNA, Messenger -- metabolism KW - Antibiotics, Antineoplastic -- pharmacology KW - Treatment Outcome KW - Male KW - RNA, Neoplasm -- metabolism KW - Doxorubicin -- analogs & derivatives KW - Octreotide -- analogs & derivatives KW - Octreotide -- pharmacology KW - Pyrroles -- therapeutic use KW - Cytotoxins -- pharmacology KW - Prostatic Neoplasms -- drug therapy KW - Neoplasms, Experimental -- pathology KW - Pyrroles -- pharmacology KW - Prostatic Neoplasms -- pathology KW - Doxorubicin -- pharmacology KW - Cytotoxins -- therapeutic use KW - Doxorubicin -- therapeutic use KW - Neoplasms, Experimental -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71369134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+oncology&rft.atitle=Effective+treatment+of+experimental+DU-145+prostate+cancers+with+targeted+cytotoxic+somatostatin+analog+AN-238.&rft.au=Plonowski%2C+Artur%3BSchally%2C+Andrew+V%3BNagy%2C+Attila%3BSun%2C+Baodong%3BHalmos%2C+Gabor&rft.aulast=Plonowski&rft.aufirst=Artur&rft.date=2002-02-01&rft.volume=20&rft.issue=2&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=International+journal+of+oncology&rft.issn=10196439&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-04-05 N1 - Date created - 2002-01-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A Comparison of State Advance Directive Documents AN - 60097400; 200215202 AB - Advance directive (AD) documents are based on state-specific statutes & vary in terms of content. These differences can create confusion & inconsistencies resulting in a possible failure to honor the health care wishes of people who execute health care documents for one state & receive health care in another state. The purpose of this study was to compare similarities & differences in the content of state AD documents. AD documents for 50 states & the District of Columbia posted on the Partnership for Caring Web site were reviewed. States & regions of the country were compared for type or types of documents used & issues included in AD documents. Three states had statutory living will documents only; however, these states did allow for appointment of a health care agent for limited end-of-life decisions. Three states had statutory durable power of attorney for health care documents only, 32 had both statutory living will & durable power of attorney for health care documents, & 13 had statutory forms that combine both types of directive in one document (advance health care directives). Of 8 identified key issues, those addressed by at least 90% of states were designation of a proxy, personal instructions for care, general life-sustaining measures, & terminal illness. When document types were compared, advance health care directive documents included more of the key issues than did living will or durable power of attorney for health care documents. This variability suggests a need for national dialogue to standardize some provisions of AD documents. 3 Tables, 2 Figures, 3 Appendixes, 23 References. Adapted from the source document. JF - Gerontologist AU - Gunter-Hunt, Gail AU - Mahoney, Jane E AU - Sieger, Carol E AD - Geriatric Research/Education/Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI gail.hunt@med.va.gov Y1 - 2002/02// PY - 2002 DA - February 2002 SP - 51 EP - 60 VL - 42 IS - 1 SN - 0016-9013, 0016-9013 KW - Discretionary Power KW - United States of America KW - Documents KW - States (Political Subdivisions) KW - Right to Die KW - Medical Decision Making KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60097400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gerontologist&rft.atitle=A+Comparison+of+State+Advance+Directive+Documents&rft.au=Gunter-Hunt%2C+Gail%3BMahoney%2C+Jane+E%3BSieger%2C+Carol+E&rft.aulast=Gunter-Hunt&rft.aufirst=Gail&rft.date=2002-02-01&rft.volume=42&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Gerontologist&rft.issn=00169013&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-10-30 N1 - Last updated - 2016-09-28 N1 - CODEN - GRNTA3 N1 - SubjectsTermNotLitGenreText - Right to Die; Discretionary Power; Medical Decision Making; Documents; States (Political Subdivisions); United States of America ER - TY - JOUR T1 - Evidence for a Deployment-Related Gulf War Syndrome by Factor Analysis AN - 18454590; 5426535 AB - To identify a syndrome unique to Gulf War veterans, the authors applied an exploratory factor analysis to the 47-symptom correlation matrix of 10,423 Gulf War and 8,960 non-Gulf War veteran respondents. A separate factor analysis was performed for Gulf War and non-Gulf War veterans, and the resulting 6 factors were compared between the 2 groups. Five of the factors were very similar in the 2 groups; however, 1 of the factors in the Gulf War group, but not the non-Gulf War group, contained a cluster of symptoms consistent with neurological impairment. Symptoms specific to this factor were blurred vision, loss of balance/dizziness, tremors/shaking, and speech difficulty. The Gulf War veterans who had all of the aforementioned symptoms ( n = 277) also reported exposures to several putative risk factors at a rate 3 or more times higher than other Gulf War veterans. This finding suggests a possible syndrome related to Gulf War deployment, which requires objective supporting clinical evidence. JF - Archives of Environmental Health AU - Kang, H K AU - Mahan, C M AU - Lee, KY AU - Murphy, F M AU - Simmens, S J AU - Young, HA AU - Levine, PH AD - Veterans Health Administration, Department of Veterans Affairs, Washington, DC, USA Y1 - 2002/02// PY - 2002 DA - Feb 2002 SP - 61 EP - 68 VL - 57 IS - 1 SN - 0003-9896, 0003-9896 KW - Gulf War Syndrome KW - Health & Safety Science Abstracts KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18454590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Environmental+Health&rft.atitle=Evidence+for+a+Deployment-Related+Gulf+War+Syndrome+by+Factor+Analysis&rft.au=Kang%2C+H+K%3BMahan%2C+C+M%3BLee%2C+KY%3BMurphy%2C+F+M%3BSimmens%2C+S+J%3BYoung%2C+HA%3BLevine%2C+PH&rft.aulast=Kang&rft.aufirst=H&rft.date=2002-02-01&rft.volume=57&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Archives+of+Environmental+Health&rft.issn=00039896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Comparison of cycling kinetics during recumbent bicycling in subjects with and without diabetes AN - 18308287; 5358993 AB - We compared recumbent bicycle kinetics in diabetic peripheral neuropathy and nondiabetic men (nine per group). 3D kinematic and force pedal data in a linked-segment model were used. The generalized muscle moment (GMM) patterns were similar between the two groups except for (1) decreased maximum knee flexor moment, (2) increased minimum knee flexor GMM, and (3) maximum hip extensor GMM by the diabetic subjects. Similar to the walking support moment, a summation moment immutable pattern was observed, although the groups accomplished it differently. The diabetic group utilized the hip during the power phase and the knee during the recovery phase. The nondiabetic group utilized both joints together during both phases. Differences in ankle GMM were not observed, suggesting further research using the recumbent bicycle as an exercise modality for diabetic peripheral neuropathy patients to enhance ankle range of motion and strength, commonly observed walking deficits. JF - Journal of Rehabilitation Research and Development AU - Perell, K L AU - Gregor, S AU - Kim, G AU - Rushatakankovit, S AU - Scremin, E AU - Levin, S AU - Gregor, R AD - Physical Medicine and Rehabilitation (117), VA Greater Los Angeles Healthcare System--West Los Angeles, Healthcare Center, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA, karen.perell@med.va.gov Y1 - 2002/02// PY - 2002 DA - Feb 2002 SP - 13 EP - 20 VL - 39 IS - 1 SN - 0007-506X, 0007-506X KW - Physical Education Index KW - Bicycling KW - Bicycle ergometry KW - Rehabilitation KW - Flexibility KW - Kinetics KW - Strength (areas of body) KW - Diabetes KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18308287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Research+and+Development&rft.atitle=Comparison+of+cycling+kinetics+during+recumbent+bicycling+in+subjects+with+and+without+diabetes&rft.au=Perell%2C+K+L%3BGregor%2C+S%3BKim%2C+G%3BRushatakankovit%2C+S%3BScremin%2C+E%3BLevin%2C+S%3BGregor%2C+R&rft.aulast=Perell&rft.aufirst=K&rft.date=2002-02-01&rft.volume=39&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Research+and+Development&rft.issn=0007506X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Diabetes; Bicycle ergometry; Rehabilitation; Kinetics; Bicycling; Flexibility; Strength (areas of body) ER - TY - JOUR T1 - Evidence for the involvement of cyclooxygenase activity in the development of cocaine sensitization AN - 18296556; 5337365 AB - Phospholipase A2 (PLA sub(2)) activation generates the release of arachidonic acid (AA) and platelet-activating factor (PAF), two compounds which may be involved in neuroplasticity. In previous studies, we found that PLA sub(2) activation is involved in the development of stimulant sensitization. In the present study, we have examined the roles of AA and PAF in the development of stimulant sensitization using agonists and antagonists selective for PAF receptors or the induction of various AA cascade-mediated eicosanoids. Sprague-Dawley rats were treated for 5 days with cocaine (30 mg/kg) or D-amphetamine (1 mg/kg) preceded 15 min earlier by various antagonists, and then tested following a 10-day withdrawal period for cocaine (15 mg/kg) or D-amphetamine (0.5 mg/kg)-induced locomotion. Consistent with our earlier work, pretreatment with the PLA sub(2) inhibitor quinacrine (25 mg/kg) blocked the development of cocaine and amphetamine sensitization. The lipoxygenase (LOX) inhibitors nordihydroguaiaretic acid (NDGA) (5-10 mg/kg) and MK-886 (1 mg/kg) had no effect on cocaine sensitization. The PAF receptor antagonist WEB 2086 (5-10 mg/kg) reduced the development of cocaine sensitization. The cyclooxygenase (COX) inhibitors indomethacin (1-2 mg/kg), piroxicam (0.5-1 mg/kg), 6-methoxy-2-napthylacetic acid (6-MNA; 0.5-1 mg/kg), and NS-398 (0.5-1 mg/kg) blocked the development of cocaine sensitization. The COX inhibitors indomethacin (2 mg/kg) and 6-MNA (1 mg/kg) also reduced the development of amphetamine sensitization. Rats were administered bilateral intraventral tegmental area (VTA) injections of D-amphetamine (5 mu g/side) or saline coadministered with indomethacin (0.5 mu g/side) or vehicle three times over 5 days and were then tested after a 10-day withdrawal for D-amphetamine (0.5 mg/kg ip)-induced locomotion. Intra-VTA amphetamine induced a robust form of amphetamine sensitization, which was blocked by coadministration of indomethacin. Unilateral intra-VTA injections of PAF (1 mu g) did not significantly alter cocaine (15 mg/kg ip)-induced locomotion when tested after a 3-day withdrawal. These findings suggest that COX, and possibly PAF, activity is involved in the development of stimulant sensitization. Neuroanatomical studies demonstrate that this may occur at the level of the VTA. JF - Pharmacology Biochemistry and Behavior AU - Reid AU - Ho, L B AU - Hsu, K AU - Fox, L AU - Tolliver, B K AU - Adams, JU AU - Franco, A AU - Berger, S P AD - Department of Psychiatry, New York University School of Medicine, Psychiatry Research 116A, New York Veterans Affairs Medical Center, 423 East 23rd Street, New York, NY 10010, USA, malcolm.reid@med.va.gov Y1 - 2002/02// PY - 2002 DA - Feb 2002 SP - 37 EP - 54 VL - 71 IS - 1-2 SN - 0091-3057, 0091-3057 KW - cyclooxygenase KW - platelet-activating factor KW - Toxicology Abstracts; Animal Behavior Abstracts KW - Platelet-activating factor KW - Locomotion KW - Sensitization KW - Cyclooxygenase KW - Arachidonic acid KW - Cocaine KW - X 24180:Social poisons & drug abuse KW - Y 25817:Mammals (excluding primates) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18296556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+Biochemistry+and+Behavior&rft.atitle=Evidence+for+the+involvement+of+cyclooxygenase+activity+in+the+development+of+cocaine+sensitization&rft.au=Reid%3BHo%2C+L+B%3BHsu%2C+K%3BFox%2C+L%3BTolliver%2C+B+K%3BAdams%2C+JU%3BFranco%2C+A%3BBerger%2C+S+P&rft.aulast=Reid&rft.aufirst=&rft.date=2002-02-01&rft.volume=71&rft.issue=1-2&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Pharmacology+Biochemistry+and+Behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Cocaine; Sensitization; Arachidonic acid; Cyclooxygenase; Platelet-activating factor; Locomotion ER - TY - JOUR T1 - Aspirin for the primary prevention of cardiovascular events: a summary of the evidence for the U.S. Preventive Services Task Force. AN - 71391502; 11790072 AB - The use of aspirin to prevent cardiovascular disease events in patients without a history of cardiovascular disease is controversial. To examine the benefits and harms of aspirin chemoprevention. MEDLINE (1966 to May 2001). 1) Randomized trials at least 1 year in duration that examined aspirin chemoprevention in patients without previously known cardiovascular disease and 2) systematic reviews, recent trials, and observational studies that examined rates of hemorrhagic strokes and gastrointestinal bleeding secondary to aspirin use. One reviewer read and extracted data from each included article and constructed evidence tables. A second reviewer checked the accuracy of the data extraction. Discrepancies were resolved by consensus. Meta-analysis was performed, and the quantitative results of the review were then used to model the consequences of treating patients with different levels of baseline risk for coronary heart disease. Five trials examined the effect of aspirin on cardiovascular events in patients with no previous cardiovascular disease. For patients similar to those enrolled in the trials, aspirin reduces the risk for the combined end point of nonfatal myocardial infarction and fatal coronary heart disease (summary odds ratio, 0.72 [95% CI, 0.60 to 0.87]). Aspirin increased the risk for hemorrhagic strokes (summary odds ratio, 1.4 [CI, 0.9 to 2.0]) and major gastrointestinal bleeding (summary odds ratio, 1.7 [CI, 1.4 to 2.1]). All-cause mortality (summary odds ratio, 0.93 [CI, 0.84 to 1.02]) was not significantly affected. For 1000 patients with a 5% risk for coronary heart disease events over 5 years, aspirin would prevent 6 to 20 myocardial infarctions but would cause 0 to 2 hemorrhagic strokes and 2 to 4 major gastrointestinal bleeding events. For patients with a risk of 1% over 5 years, aspirin would prevent 1 to 4 myocardial infarctions but would cause 0 to 2 hemorrhagic strokes and 2 to 4 major gastrointestinal bleeding events. The net benefit of aspirin increases with increasing cardiovascular risk. In the decision to use aspirin chemoprevention, the patient's cardiovascular risk and relative utility for the different clinical outcomes prevented or caused by aspirin use must be considered. JF - Annals of internal medicine AU - Hayden, Michael AU - Pignone, Michael AU - Phillips, Christopher AU - Mulrow, Cynthia AD - Division of General Medicine, Department of Medicine, 11C Ambulatory Care, Veterans Administration Medical Center, USA. Y1 - 2002/01/15/ PY - 2002 DA - 2002 Jan 15 SP - 161 EP - 172 VL - 136 IS - 2 KW - Fibrinolytic Agents KW - 0 KW - Aspirin KW - R16CO5Y76E KW - Abridged Index Medicus KW - Index Medicus KW - Evidence-Based Medicine KW - Humans KW - Aged KW - Gastrointestinal Hemorrhage -- chemically induced KW - Primary Prevention KW - Risk Factors KW - Adult KW - Middle Aged KW - Stroke -- prevention & control KW - Chemoprevention KW - United States -- epidemiology KW - Female KW - Male KW - Stroke -- chemically induced KW - Fibrinolytic Agents -- therapeutic use KW - Coronary Disease -- prevention & control KW - Aspirin -- adverse effects KW - Aspirin -- therapeutic use KW - Fibrinolytic Agents -- adverse effects KW - Coronary Disease -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71391502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Aspirin+for+the+primary+prevention+of+cardiovascular+events%3A+a+summary+of+the+evidence+for+the+U.S.+Preventive+Services+Task+Force.&rft.au=Hayden%2C+Michael%3BPignone%2C+Michael%3BPhillips%2C+Christopher%3BMulrow%2C+Cynthia&rft.aulast=Hayden&rft.aufirst=Michael&rft.date=2002-01-15&rft.volume=136&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-04-03 N1 - Date created - 2002-01-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Intern Med. 2002 Oct 1;137(7):622-3 [12353960] Ann Intern Med. 2005 Jun 7;142(11):942-3 [15941704] J Fam Pract. 2002 May;51(5):415 [12019044] ACP J Club. 2002 Jul-Aug;137(1):6 [12093205] Summary For Patients In: Ann Intern Med. 2002 Jan 15;136(2):I55 [11928737] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of bradykinin in acid-induced mesenteric hyperemia and duodenal villous damage. AN - 71443179; 11837250 AB - Intestinal mucosal capsaicin-sensitive afferent nerves mediate, in part, the mesenteric hyperemia after intraduodenal acidification. The hyperemia plays a role in protecting the duodenal mucosa against acid damage. We tested the hypothesis that bradykinin contributes to this protective hyperemia. A specific antagonist of bradykinin will attenuate the hyperemia and exacerbate duodenal villous damage induced by acid. Study 1: Intravenous vehicle, or the specific bradykinin B2 receptor antagonist (HOE 140) was administered to anesthetized rats. This was followed by intraduodenal bolus administration of 160 microM capsaicin or 0.1 N HCl, and then intravenous bradykinin. Study 2: Intravenous administration of vehicle or HOE 140 was followed by duodenal perfusion with 0.1 N HCl. Superior mesenteric artery blood flow (pulsed Doppler flowmetry) (Study 1) and duodenal villous damage (histology) (Study 2) were recorded. HOE 140 significantly reduced the hyperemia induced by bradykinin and intraduodenal capsaicin or acid. Deep villous injury was significantly increased after treatment with HOE 140. These findings support the hypothesis that acid-induced and afferent nerve-mediated mesenteric hyperemia is modulated by a mechanism that involves bradykinin B2 receptor. Antagonism of bradykinin B2 receptor also increased acid-induced deep duodenal villous damage. Thus, maintenance of bradykinin-mediated mesenteric hyperemia, is a previous unrecognized mechanism associated with protection of the rat duodenal mucosa against acid-induced damage. JF - Life sciences AU - Leung, Felix W AU - Iwata, Fumihiro AU - Kao, John AU - Seno, Kyoji AU - Itoh, Makoto AU - Leung, Joseph W C AD - Research and Medical Services, Sepulveda Ambulatory Care Center and Nursing Home, Greater Los Angeles Healthcare System, Sepulveda, CA 91343, USA. felix.leung@wla.va.gov Y1 - 2002/01/04/ PY - 2002 DA - 2002 Jan 04 SP - 779 EP - 790 VL - 70 IS - 7 SN - 0024-3205, 0024-3205 KW - Bradykinin Receptor Antagonists KW - 0 KW - icatibant KW - 7PG89G35Q7 KW - Hydrochloric Acid KW - QTT17582CB KW - Capsaicin KW - S07O44R1ZM KW - Bradykinin KW - S8TIM42R2W KW - Index Medicus KW - Ultrasonography, Doppler, Pulsed KW - Animals KW - Mesenteric Artery, Superior -- physiopathology KW - Blood Flow Velocity -- drug effects KW - Hydrochloric Acid -- pharmacology KW - Capsaicin -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Intestinal Mucosa -- drug effects KW - Intestinal Mucosa -- pathology KW - Mesenteric Artery, Superior -- drug effects KW - Male KW - Mesentery -- drug effects KW - Duodenum -- drug effects KW - Bradykinin -- analogs & derivatives KW - Hyperemia -- chemically induced KW - Bradykinin -- pharmacology KW - Bradykinin -- physiology KW - Hyperemia -- physiopathology KW - Mesentery -- physiopathology KW - Duodenum -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71443179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Role+of+bradykinin+in+acid-induced+mesenteric+hyperemia+and+duodenal+villous+damage.&rft.au=Leung%2C+Felix+W%3BIwata%2C+Fumihiro%3BKao%2C+John%3BSeno%2C+Kyoji%3BItoh%2C+Makoto%3BLeung%2C+Joseph+W+C&rft.aulast=Leung&rft.aufirst=Felix&rft.date=2002-01-04&rft.volume=70&rft.issue=7&rft.spage=779&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-22 N1 - Date created - 2002-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association and linkage disequilibrium between a functional polymorphism of the dopamine-2 receptor gene and schizophrenia in a genetically homogeneous Portuguese population AN - 759317203; 13686100 AB - A functional polymorphism in the promoter region of the DRD2 gene has been found to be associated with schizophrenia in Japanese super(1,2) and Swedish populations. super(3) We attempted to replicate these findings in a genetically homogenous Portuguese population using a family-based study design. Analysis of 78 trios revealed evidence for association between the -141C Ins allele and schizophrenia using the haplotype relative risk (HRR) method ( chi super(2)=9.30, P=0.0023). Further examination of this sample using an alternative family-based association analysis method, the transmission disequilibrium test (TDT), of 33 informative matings from the Portuguese trios provided evidence for an allelic association and linkage disequilibrium between the insertion allele and schizophrenia ( chi super(2)=8.76, P=0.0031). These consistent results using two alternative family-based association analysis methods replicate the findings of previous reports, and thus further implicate a potential role for the dopamine-2 receptor in the genetic etiology of schizophrenia.MOLECULAR PSYCHIATRY: (2002) 7, 1002-1005. doi:10.1038/sj.mp.4001126 JF - Molecular Psychiatry AU - Schindler, K M AU - Pato, M T AU - Dourado, A AU - Macedo, A AU - Azevedo, M H AU - Kennedy, J L AU - Pato, C N AD - [1] Center for Psychiatric and Molecular Genetics, SUNY Upstate Medical University; and Behavioral Health Care Line, VISN 2, Veterans Administration, Syracuse, New York, USA [2] Department of Pharmacology and Toxicology, SUNY at Buffalo, New York, USA Y1 - 2002 PY - 2002 DA - 2002 SP - 1002 EP - 1005 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 7 IS - 9 SN - 1359-4184, 1359-4184 KW - Toxicology Abstracts; CSA Neurosciences Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759317203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Psychiatry&rft.atitle=Association+and+linkage+disequilibrium+between+a+functional+polymorphism+of+the+dopamine-2+receptor+gene+and+schizophrenia+in+a+genetically+homogeneous+Portuguese+population&rft.au=Schindler%2C+K+M%3BPato%2C+M+T%3BDourado%2C+A%3BMacedo%2C+A%3BAzevedo%2C+M+H%3BKennedy%2C+J+L%3BPato%2C+C+N&rft.aulast=Schindler&rft.aufirst=K&rft.date=2002-01-01&rft.volume=7&rft.issue=9&rft.spage=1002&rft.isbn=&rft.btitle=&rft.title=Molecular+Psychiatry&rft.issn=13594184&rft_id=info:doi/10.1038%2Fsj.mp.4001126 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1038/sj.mp.4001126 ER - TY - JOUR T1 - Ulcers, Helicobacter pylori infection, platelets and gastrointestinal complications of non-steroidal anti-inflammatory drugs: what are the connections? AN - 72926689; 16144207 AB - The term "gastropathy", and discussion surrounding the adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs) on the gastrointestinal (GI) tract, suggests that most of the complications arise from injury to the gastric mucosa, resulting in gastric ulcers that develop complications. The commonest GI complication is bleeding, which results principally from thrombocytopathy or impaired platelet function in the presence of various underlying GI conditions, including but not confined to antecedent peptic ulcer disease, and in some cases ulcers caused by NSAIDs. In unselected cases, bleeding as a result of aspirin or NSAID may occur early in the course of treatment, much of it predictable from a careful history, taken to identify well-defined risk factors, including previous peptic ulcer disease, GI bleeding, or concomitant treatment with steroids, anticoagulants, or anti-platelet drugs. Only in the presence of such risk factors is NSAID use likely to be associated with a serious GI complication. Although GI complications are common in such cases, attributability of the event solely to NSAIDs is low. Attributability of the complication to the drug is highest when NSAID use is the sole risk factor: the estimated incidence of complications in this setting is only about 10% of all NSAID-associated GI complications. In estimating the likely outcome of therapy, the risk factors identifiable from the history in each case before treatment are more important than the choice of NSAID. Independently analysed, the VIGOR and CLASS trials showed that use of rofecoxib or celecoxib caused fewer clinical ulcers and bleeding, but much of the bleeding observed did not arise from ulcers or from sites proximal to the ligament of Treitz. This suggests that the main value of these drugs is the absence of thrombocytopathy: their safety is substantially reduced by concomitant treatment with low doses of aspirin. This paper analyses the separate roles of COX 2-selective agents, H. pylori eradication, and concomitant aspirin prophylaxis or treatment with acid-suppressant drugs. JF - The European journal of surgery. Supplement. : = Acta chirurgica. Supplement AU - McCarthy, Denis M AD - Veterans Administration Medical Center and University of New Mexico School of Medicine, Albuquerque, New Mexico 87108, USA. denis.mccarthy2@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 89 EP - 99 IS - 587 SN - 1102-416X, 1102-416X KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase Inhibitors KW - Lactones KW - Sulfones KW - rofecoxib KW - 0QTW8Z7MCR KW - Diclofenac KW - 144O8QL0L1 KW - Naproxen KW - 57Y76R9ATQ KW - Ibuprofen KW - WK2XYI10QM KW - Index Medicus KW - Blood Platelets -- drug effects KW - Humans KW - Naproxen -- pharmacology KW - Blood Platelets -- physiology KW - Helicobacter Infections KW - Diclofenac -- therapeutic use KW - Cyclooxygenase Inhibitors -- therapeutic use KW - Lactones -- therapeutic use KW - Diclofenac -- pharmacology KW - Naproxen -- therapeutic use KW - Ibuprofen -- therapeutic use KW - Sulfones -- therapeutic use KW - Risk Factors KW - Gastrointestinal Hemorrhage -- epidemiology KW - Peptic Ulcer -- drug therapy KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Peptic Ulcer -- microbiology KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Gastrointestinal Hemorrhage -- chemically induced KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72926689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+journal+of+surgery.+Supplement.+%3A+%3D+Acta+chirurgica.+Supplement&rft.atitle=Ulcers%2C+Helicobacter+pylori+infection%2C+platelets+and+gastrointestinal+complications+of+non-steroidal+anti-inflammatory+drugs%3A+what+are+the+connections%3F&rft.au=McCarthy%2C+Denis+M&rft.aulast=McCarthy&rft.aufirst=Denis&rft.date=2002-01-01&rft.volume=&rft.issue=587&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=The+European+journal+of+surgery.+Supplement.+%3A+%3D+Acta+chirurgica.+Supplement&rft.issn=1102416X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-13 N1 - Date created - 2005-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Allopurinol for chronic prostatitis. AN - 72811949; 12519549 AB - Chronic prostatitis is a condition that causes men substantial morbidity through the associated constellation of urinary symptoms, sexual dysfunction, and pelvic pain. The etiology of chronic prostatitis is unknown, and the many and varied treatments for chronic prostatitis reflect in part this knowledge gap. One novel etiologic theory is that the reflux of urine into prostatic ducts causes prostatic inflammation via high concentrations of purine and pyrimidine base-containing metabolites in prostatic secretions. This theory has led to the use of allopurinol for treatment of chronic prostatitis in hopes of lowering prostatic levels of uric acid and improving symptoms. To determine the effects of allopurinol in the treatment of chronic prostatitis Trials were searched in computerized general and specialized databases (MEDLINE, Cochrane Library, Cochrane Prostate Group database), bibliographies of obtained articles, and direct contact with authors. All randomized trials of allopurinol versus placebo used to treat patients with chronic prostatitis. Acute prostatitis, bacterial prostatitis, and asymptomatic prostatitis were excluded. The main outcome measure was the change in patient-reported discomfort. The reviewers extracted the data independently for the outcomes of change in patient-reported discomfort, investigator graded prostate pain, leukocyte counts, and biochemical indices. In this update, no new trials were identified (08/2002). Only one trial with 54 men lasting 240 days (with 330 days of follow-up) met study inclusion criteria. There was a statistically significant change favoring allopurinol in patient-reported discomfort between the study and control groups at follow-up. Between days 45-225, the mean score was -0.95 (s.d. 0.19) for the allopurinol group (7 men), compared with -0.47 (s.d. 0.21) for the placebo group (7 men). The weighted mean difference (WMD) was -0.48 (95%CI -0.690, -0.270). The mean score between days 45-135 was -1.08 (s.d. 1.29) for the 25 men in the allopurinol group, compared with -0.21 (sd 0.97) for the 14 men in the control group. The WMD was -0.87 (95%CI -1.587, -0.153). The allopurinol group had significantly less investigator graded prostate pain and had lower levels of serum urate, urine urate, and expressed prostatic secretion urate and xanthine. No significant differences between the two groups regarding leukocyte counts were found. No patient receiving allopurinol had any significant side effects. Three patients in the placebo group dropped out because of side effects. One small trial of allopurinol for treating chronic prostatitis showed improvements in patient-reported symptom improvement, investigator-graded prostate pain, and biochemical parameters. However, the data provided, the measures used, and the statistics presented do not make these findings convincing that changes in urine and prostatic secretion composition regarding purine and pyrimidine bases resulted in the relief of symptoms. Further studies of allopurinol treatment using standardized and validated outcomes measures and analyses are necessary to determine whether allopurinol is effective. JF - The Cochrane database of systematic reviews AU - McNaughton, C O AU - Wilt, T AD - General Internal Medicine (111-0), Minneapolis VA/VISN 13 Center for Chronic Disease Outcomes Research, One Veterans Drive, Minneapolis, Minnesota 55417, USA. MACDONALD.RODERICK@minneapolis.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 1 IS - 4 KW - Antimetabolites KW - 0 KW - Allopurinol KW - 63CZ7GJN5I KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Humans KW - Chronic Disease KW - Male KW - Allopurinol -- therapeutic use KW - Prostatitis -- drug therapy KW - Antimetabolites -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72811949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Cochrane+database+of+systematic+reviews&rft.atitle=Allopurinol+for+chronic+prostatitis.&rft.au=McNaughton%2C+C+O%3BWilt%2C+T&rft.aulast=McNaughton&rft.aufirst=C&rft.date=2002-01-01&rft.volume=&rft.issue=4&rft.spage=CD001041&rft.isbn=&rft.btitle=&rft.title=The+Cochrane+database+of+systematic+reviews&rft.issn=1469-493X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-02-21 N1 - Date created - 2003-01-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Update Of: Cochrane Database Syst Rev. 2000;(2):CD001041 [10796738] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A prospective study of the incidence and open-label treatment of interferon-induced major depressive disorder in patients with hepatitis C. AN - 72621840; 12399946 AB - Interferon (IFN) therapy has been associated with the development of Major Depressive Disorder (MDD) when given to patients with hepatitis C (HCV). The incidence, time course, risk factors, and treatment of IFN-induced MDD are poorly understood. The objectives of the present study were to determine the incidence of IFN-induced MDD, as well as to determine the efficacy of open-label antidepressant treatment, in particular selective serotonin reuptake inhibitors (SSRIs) for IFN-induced MDD. Thirty-nine HCV patients on IFN therapy were monitored weekly using the Beck Depression Inventory (BDI). Those who became depressed were treated with citalopram, a SSRI antidepressant. Main outcome measures included the incidence of IFN-induced MDD, as well as response rates to antidepressants in those patients who developed IFN-induced MDD. Our results showed that 13 of 39 patients (33%) developed IFN-induced MDD. There were no differences in age, gender, past history of MDD, or substance use between those who became depressed and those who did not. However, there were significantly fewer African American patients in the depressed group. Patients who developed IFN-induced MDD were on IFN therapy for an average of 12.1 weeks prior to the development of MDD. Eleven of 13 patients (85%) were responsive to antidepressant treatment. We conclude that IFN-induced MDD is common in HCV patients. Health care providers should follow IFN-treated HCV patients for the development of MDD, particularly between the 2nd and 5th months of IFN therapy. SSRIs, in particular citalopram, are an effective treatment for IFN-induced depression in HCV patients. JF - Molecular psychiatry AU - Hauser, P AU - Khosla, J AU - Aurora, H AU - Laurin, J AU - Kling, M A AU - Hill, J AU - Gulati, M AU - Thornton, A J AU - Schultz, R L AU - Valentine, A D AU - Meyers, C A AU - Howell, C D AD - Portland VA Medical Center, Behavioral Health and Neurosciences Division, NW Hepatitis C Field Based Resource Center/Oregon Health & Sciences University, Portland, OR 97201, USA. Peter.Hauser2@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 942 EP - 947 VL - 7 IS - 9 SN - 1359-4184, 1359-4184 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Antiviral Agents KW - Citalopram KW - 0DHU5B8D6V KW - Interferons KW - 9008-11-1 KW - Index Medicus KW - Prospective Studies KW - Humans KW - Adult KW - Treatment Outcome KW - Incidence KW - Middle Aged KW - Male KW - Female KW - Hepatitis C -- drug therapy KW - Depressive Disorder, Major -- drug therapy KW - Interferons -- adverse effects KW - Depressive Disorder, Major -- chemically induced KW - Antidepressive Agents, Second-Generation -- administration & dosage KW - Citalopram -- administration & dosage KW - Antiviral Agents -- adverse effects KW - Hepatitis C -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72621840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+psychiatry&rft.atitle=A+prospective+study+of+the+incidence+and+open-label+treatment+of+interferon-induced+major+depressive+disorder+in+patients+with+hepatitis+C.&rft.au=Hauser%2C+P%3BKhosla%2C+J%3BAurora%2C+H%3BLaurin%2C+J%3BKling%2C+M+A%3BHill%2C+J%3BGulati%2C+M%3BThornton%2C+A+J%3BSchultz%2C+R+L%3BValentine%2C+A+D%3BMeyers%2C+C+A%3BHowell%2C+C+D&rft.aulast=Hauser&rft.aufirst=P&rft.date=2002-01-01&rft.volume=7&rft.issue=9&rft.spage=942&rft.isbn=&rft.btitle=&rft.title=Molecular+psychiatry&rft.issn=13594184&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-30 N1 - Date created - 2002-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pilot double blind placebo controlled trial of sertraline with naltrexone in the treatment of opiate dependence. AN - 72038453; 12202015 AB - Naltrexone has been used for thirty years as an aid to maintenance of opiate abstinence with limited success. One reason is that naltrexone does not appear to reduce craving in opiate addiction, unlike in alcoholism. The authors conducted this trial of naltrexone in combination with the SSRI sertraline to assess treatment retention with combination pharmacotherapy. They used a double-blind placebo controlled trial of naltrexone 50 mg qd with placebo versus naltrexone 50 mg plus sertraline 50 mg qd in 13 recently nondepressed abstinent opiate addicts followed over a 12 week period. Both groups had a similar side effect profile and while there was an initial trend in increased retention in the combination therapy group, there was no difference in retention by the end of the study. There was a fall in the Beck Depression Inventory scores in both groups over time, and there was a significant negative correlation between BDI scores and duration in treatment in the combination therapy group. There was a fall in opiate craving, as measured by an opiate craving questionnaire, over time in both groups. The authors conclude that combination pharmacotherapy appeared to be well tolerated and was initially successful in increasing treatment retention relative to naltrexone alone, but this effect tended to diminish over time. JF - The American journal on addictions AU - Farren, Conor K AU - O'Malley, Stephanie AD - Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA. conor.farren@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 228 EP - 234 VL - 11 IS - 3 SN - 1055-0496, 1055-0496 KW - Narcotic Antagonists KW - 0 KW - Serotonin Uptake Inhibitors KW - Naltrexone KW - 5S6W795CQM KW - Sertraline KW - QUC7NX6WMB KW - Index Medicus KW - Drug Therapy, Combination KW - Double-Blind Method KW - Humans KW - Adult KW - Pilot Projects KW - Male KW - Female KW - Sertraline -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Opioid-Related Disorders -- rehabilitation KW - Naltrexone -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72038453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=A+pilot+double+blind+placebo+controlled+trial+of+sertraline+with+naltrexone+in+the+treatment+of+opiate+dependence.&rft.au=Farren%2C+Conor+K%3BO%27Malley%2C+Stephanie&rft.aulast=Farren&rft.aufirst=Conor&rft.date=2002-01-01&rft.volume=11&rft.issue=3&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-09 N1 - Date created - 2002-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antipsychotic prescribing practices in the Veterans Healthcare Administration--New York metropolitan region. AN - 71784248; 12047020 AB - Most research literature concerning pharmacological treatments reports results from controlled clinical trials, which provide data critical to assess the efficacy of new treatments in research populations. Fewer studies examine how treatments are adopted in everyday practice settings, where comorbid disorders and environmental issues typically complicate patients' situations. In this study, we examine the evolution of antipsychotic prescribing practices in the New York region of the Veterans Healthcare Administration (VHA) from 1998 to 2000 using administrative data. Second generation antipsychotic medications are now prescribed more frequently than the older antipsychotic medications, with a concomitant increase in cost. Data show low rates of clozapine use, relatively high rates of polypharmacy, and intersite variation in prescribing practices. Additional research in everyday practice settings is needed to address clinical questions unlikely to be answered through traditional efficacy research and to examine reasons for intersite differences in prescribing patterns. JF - Schizophrenia bulletin AU - Weissman, Ellen M AD - Bronx VA Medical Center, NY 10468, USA. Ellen.Weissman@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 31 EP - 42 VL - 28 IS - 1 SN - 0586-7614, 0586-7614 KW - Antipsychotic Agents KW - 0 KW - Dibenzothiazepines KW - Benzodiazepines KW - 12794-10-4 KW - Quetiapine Fumarate KW - 2S3PL1B6UJ KW - Pirenzepine KW - 3G0285N20N KW - Clozapine KW - J60AR2IKIC KW - Risperidone KW - L6UH7ZF8HC KW - olanzapine KW - N7U69T4SZR KW - Index Medicus KW - Drug Utilization -- trends KW - Humans KW - Aged KW - Clozapine -- adverse effects KW - Hospitals, Veterans -- statistics & numerical data KW - Drug Therapy, Combination KW - New York City KW - Dibenzothiazepines -- adverse effects KW - Clozapine -- therapeutic use KW - Adult KW - Middle Aged KW - Risperidone -- adverse effects KW - Risperidone -- therapeutic use KW - Male KW - Dibenzothiazepines -- therapeutic use KW - Drug Prescriptions -- statistics & numerical data KW - Urban Population -- statistics & numerical data KW - Pirenzepine -- analogs & derivatives KW - Antipsychotic Agents -- therapeutic use KW - Veterans -- psychology KW - Schizophrenia -- drug therapy KW - Antipsychotic Agents -- adverse effects KW - Pirenzepine -- therapeutic use KW - Pirenzepine -- adverse effects KW - Antipsychotic Agents -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71784248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+bulletin&rft.atitle=Antipsychotic+prescribing+practices+in+the+Veterans+Healthcare+Administration--New+York+metropolitan+region.&rft.au=Weissman%2C+Ellen+M&rft.aulast=Weissman&rft.aufirst=Ellen&rft.date=2002-01-01&rft.volume=28&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+bulletin&rft.issn=05867614&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-12-19 N1 - Date created - 2002-06-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Schizophr Bull. 2002;28(1):127-9 [12047012] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessment of oxidants in mitogen-activated protein kinase activation. AN - 71535979; 11912922 JF - Methods in enzymology AU - Terada, Lance S AU - Souza, Rhonda F AD - University of Texas, Southwestern Medical Center, Dallas Veterans Administration Medical Center, Dallas, Texas 75216, USA. Y1 - 2002 PY - 2002 DA - 2002 SP - 313 EP - 320 VL - 349 SN - 0076-6879, 0076-6879 KW - Fluoresceins KW - 0 KW - Oxidants KW - Phosphoproteins KW - Tumor Necrosis Factor-alpha KW - Superoxides KW - 11062-77-4 KW - diacetyldichlorofluorescein KW - 2044-85-1 KW - NADPH Oxidase KW - EC 1.6.3.1 KW - neutrophil cytosolic factor 1 KW - Mitogen-Activated Protein Kinase 8 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinases KW - Index Medicus KW - Superoxides -- metabolism KW - Phosphoproteins -- genetics KW - Transfection KW - Fluoresceins -- metabolism KW - Humans KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Enzyme Activation -- drug effects KW - Mutation KW - Signal Transduction KW - Cell Line KW - Mitogen-Activated Protein Kinases -- metabolism KW - Oxidants -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71535979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+enzymology&rft.atitle=Assessment+of+oxidants+in+mitogen-activated+protein+kinase+activation.&rft.au=Terada%2C+Lance+S%3BSouza%2C+Rhonda+F&rft.aulast=Terada&rft.aufirst=Lance&rft.date=2002-01-01&rft.volume=349&rft.issue=&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Methods+in+enzymology&rft.issn=00766879&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-05-20 N1 - Date created - 2002-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): final results. AN - 71373549; 11779900 AB - A previous trial (the Clomethiazole Acute Stroke Study) generated the hypothesis that clomethiazole is effective in patients with a major ischemic stroke (total anterior circulation syndrome), and this was tested in the present study. A total of 1198 patients with major ischemic stroke and a combination of limb weakness, higher cortical dysfunction, and visual field deficits were randomly assigned to clomethiazole (68 mg/kg IV over 24 hours) or placebo. The study drug was initiated within 12 hours of symptom onset. Functional outcome and neurological recovery were assessed at days 7, 30, and 90, with the proportion of patients with a Barthel Index > or =60 at last follow-up as the primary outcome measure. The patients were randomly assigned equally, and the two treatment groups were well matched for baseline characteristics, including stroke severity (mean National Institutes of Health Stroke Scale score 16.9+/-5.2). Ninety-six percent were classified as total anterior circulation syndrome. The proportion of patients reaching a Barthel Index score of > or =60 was 42% in the clomethiazole-treated group and 46% in the placebo-treated group (odds ratio, 0.81; 95% CI, 0.62 to 1.05; P=0.11). There was no evidence of efficacy on any secondary outcome variables (modified Rankin Score, National Institutes of Health Stroke Scale, Scandinavian Stroke Scale, and 30-day CT infarct volumes) compared with placebo. Subgroup analysis showed a similar lack of treatment effect in patients treated early (<6 hours) and in those treated later (6 to 12 hours). Somnolence was an expected pharmacological effect of clomethiazole, and this occurred during treatment as an adverse event in half of the patients randomly assigned to study drug. The target population was selected, and sufficient drug was given to produce the expected pharmacological effect in the brain. Clomethiazole does not improve outcome in patients with major ischemic stroke. JF - Stroke AU - Lyden, P AU - Shuaib, A AU - Ng, K AU - Levin, K AU - Atkinson, R P AU - Rajput, A AU - Wechsler, L AU - Ashwood, T AU - Claesson, L AU - Odergren, T AU - Salazar-Grueso, E AU - CLASS-I/H/T Investigators AD - Department of Neurosciences, UCSD School of Medicine, and Neurology, Veterans Administration Medical Center, San Diego, CA, USA. plyden@ucsd.edu ; CLASS-I/H/T Investigators Y1 - 2002/01// PY - 2002 DA - January 2002 SP - 122 EP - 128 VL - 33 IS - 1 KW - GABA Modulators KW - 0 KW - Neuroprotective Agents KW - Chlormethiazole KW - 0C5DBZ19HV KW - Index Medicus KW - Acute Disease KW - Double-Blind Method KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Time Factors KW - Male KW - Female KW - GABA Modulators -- therapeutic use KW - Neuroprotective Agents -- administration & dosage KW - Chlormethiazole -- therapeutic use KW - Stroke -- drug therapy KW - Brain Ischemia -- diagnosis KW - Brain Ischemia -- drug therapy KW - GABA Modulators -- adverse effects KW - Neuroprotective Agents -- adverse effects KW - Chlormethiazole -- administration & dosage KW - Stroke -- diagnosis KW - GABA Modulators -- administration & dosage KW - Neuroprotective Agents -- therapeutic use KW - Chlormethiazole -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71373549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stroke&rft.atitle=Clomethiazole+Acute+Stroke+Study+in+ischemic+stroke+%28CLASS-I%29%3A+final+results.&rft.au=Lyden%2C+P%3BShuaib%2C+A%3BNg%2C+K%3BLevin%2C+K%3BAtkinson%2C+R+P%3BRajput%2C+A%3BWechsler%2C+L%3BAshwood%2C+T%3BClaesson%2C+L%3BOdergren%2C+T%3BSalazar-Grueso%2C+E%3BCLASS-I%2FH%2FT+Investigators&rft.aulast=Lyden&rft.aufirst=P&rft.date=2002-01-01&rft.volume=33&rft.issue=1&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Stroke&rft.issn=1524-4628&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-01 N1 - Date created - 2002-01-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Stroke. 2002 Jan;33(1):128-9 [11817345] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prognosis of Older Patients in Mixed-Age Alcoholism Treatment Programs AN - 61483017; 200205399 AB - Older patients were compared with matched groups of younger & middle-aged patients in inpatient alcohol treatment programs (N = 432 in each age group). Compared with other patients, older patients had poorer physical health & lower cognitive status at treatment entry, but they were drinking less & reported fewer drinking-related problems, fewer psychological symptoms, more social support, more adaptive coping, & fewer barriers to abstinence. Older patients had positive views of the programs &, except for less family therapy & problem-focused counseling, received comparable treatment to that received by other patients. At discharge, older patients showed significant change in most areas targeted for treatment. Better initial status was the strongest predictor of better discharge functioning. Patients with higher cognitive functioning & stronger treatment motivation & those who experienced more interpersonal support & who received more specialized treatment services showed better-than-expected improvement. The age groups showed similar outcomes, prognostic factors, & response to different treatment orientations. 5 Tables, 36 References. Adapted from the source document. JF - Journal of Substance Abuse Treatment AU - Lemke, Sonne AU - Moos, Rudolf H AD - Center Health Care Evaluation/Program Evaluation/Resource Center, Veteran Affairs Health Care System, Menlo Park, CA sonne.lemke@med.va.gov Y1 - 2002/01// PY - 2002 DA - January 2002 SP - 33 EP - 43 VL - 22 IS - 1 SN - 0740-5472, 0740-5472 KW - Treatment Outcomes KW - Alcohol Abuse KW - Treatment Programs KW - Elderly KW - Young Adults KW - Middle Aged Adults KW - Age Differences KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61483017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Prognosis+of+Older+Patients+in+Mixed-Age+Alcoholism+Treatment+Programs&rft.au=Lemke%2C+Sonne%3BMoos%2C+Rudolf+H&rft.aulast=Lemke&rft.aufirst=Sonne&rft.date=2002-01-01&rft.volume=22&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2007-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Treatment Programs; Alcohol Abuse; Elderly; Middle Aged Adults; Young Adults; Treatment Outcomes; Age Differences ER - TY - JOUR T1 - A clinical strain of Escherichia coli possessing CMY-2 plasmid-mediated amp C beta -lactamase: An emerging concern in pediatrics AN - 18666043; 5569017 AB - A 5-year-old child was colonized by an isolate of Escherichia coli that transferred resistance to third-generation cephalosporins and cefoxitin. This resistance phenotype was encoded on a >75-kb plasmid pLRM 22. The transferable plasmid contained both bla sub(CMY-2) and bla sub(TEM-1b). Increasing reports of CMY-2 beta -lactamase in clinical isolates in children raise concerns about the empiric use of third-generation cephalosporins in this patient group. JF - Microbial Drug Resistance AU - Hoyen, C M AU - Hujer, AM AU - Hujer, K M AU - Marshall, SH AU - Carias, L AU - Toltzis, P AU - Rice, L B AU - Bonomo, R A AD - Infectious Disease Section, Louis Stokes Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA, robert.bonomo@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 329 EP - 334 VL - 8 IS - 4 SN - 1076-6294, 1076-6294 KW - CMY-2 protein KW - Plasmid pLRM22 KW - TEM-1b protein KW - Microbiology Abstracts B: Bacteriology KW - J 02795:Antibiotic resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18666043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Drug+Resistance&rft.atitle=A+clinical+strain+of+Escherichia+coli+possessing+CMY-2+plasmid-mediated+amp+C+beta+-lactamase%3A+An+emerging+concern+in+pediatrics&rft.au=Hoyen%2C+C+M%3BHujer%2C+AM%3BHujer%2C+K+M%3BMarshall%2C+SH%3BCarias%2C+L%3BToltzis%2C+P%3BRice%2C+L+B%3BBonomo%2C+R+A&rft.aulast=Hoyen&rft.aufirst=C&rft.date=2002-01-01&rft.volume=8&rft.issue=4&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Microbial+Drug+Resistance&rft.issn=10766294&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Optimization of electroporation conditions for Mycobacterium avium AN - 18653077; 5558838 AB - Successful transformation and subsequent genetic manipulation of Mycobacterium avium requires suitable vectors, efficient transformation systems, and reliable selectable markers. A systematic analysis of the parameters involved in the transformation of M. avium was performed to optimize DNA transfer. Factors examined included the composition of the growth medium, growth medium additives, variations in washing of the bacteria prior to electroporation, and conditions of electroporation. Of the parameters assayed, the frequency of transformation (defined as the number of transformants per 10 super(6) transformed bacteria) showed the greatest increase with the addition of 1.5% glycine to the M. avium culture medium and the use of higher concentrations of plasmid DNA. The addition of 0.5 M sucrose to the growth medium and wash solution yielded a modest increase in transformation frequency, but more importantly afforded greater consistency of results between different batches of cells with no decrease in transformation yields following freezing and thawing. We also confirmed that gfp could be used as a selective marker for M. avium, even as a single copy integrant, and allowed for rapid discrimination between false and true transformants. Using this protocol, we were able to transform nine of 11 clinical strains of M. avium. JF - Tuberculosis AU - Lee, S-H AU - Cheung, M AU - Irani, V AU - Carroll, J D AU - Inamine, J M AU - Howe, W R AU - Maslow, J N AD - VA Medical Center (151), University and Woodland Aves., Philadelphia, PA 19104, USA, joel.maslow@med.va.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 167 EP - 174 VL - 82 IS - 4-5 SN - 1472-9792, 1472-9792 KW - sucrose KW - Microbiology Abstracts B: Bacteriology KW - J 02725:DNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18653077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tuberculosis&rft.atitle=Optimization+of+electroporation+conditions+for+Mycobacterium+avium&rft.au=Lee%2C+S-H%3BCheung%2C+M%3BIrani%2C+V%3BCarroll%2C+J+D%3BInamine%2C+J+M%3BHowe%2C+W+R%3BMaslow%2C+J+N&rft.aulast=Lee&rft.aufirst=S-H&rft.date=2002-01-01&rft.volume=82&rft.issue=4-5&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Tuberculosis&rft.issn=14729792&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Tinea corporis gladiatorum AN - 18482969; 5440376 AB - Many cutaneous disorders are reported in wrestlers. Most of these conditions are infectious. Herpes simplex infection in wrestlers is quite well known, but recently, dermatophyte infection has received increased attention. Tinea corporis gladiatorum, caused in most cases by Trichophyton tonsurans, infects wrestlers at alarming rates. Transmission of this infection is primarily through skin-to-skin contact. The rapid identification and treatment of tinea corporis gladiatorum is vital to minimize disruption in team practices and competitions. Preventive measures, including pharmacologic intervention, are paramount. JF - Journal of the American Academy of Dermatology AU - Adams, B B AD - Affiliation University of Cincinnati, College of Medicine, Department of Dermatology, and Veterans Administration Medical Center, OH 45267-0592, USA. Y1 - 2002 PY - 2002 DA - 2002 SP - 286 EP - 290 VL - 47 SN - 0190-9622, 0190-9622 KW - Physical Education Index KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18482969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Tinea+corporis+gladiatorum&rft.au=Adams%2C+B+B&rft.aulast=Adams&rft.aufirst=B&rft.date=2002-01-01&rft.volume=47&rft.issue=&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=01909622&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER -